"Proteins Unique Sequence ID" "Checked" "Protein FDR Confidence: Combined" "Master" "Accession" "Description" "Exp. q-value: Combined" "Contaminant" "Sum PEP Score" "Coverage [%]" "# Peptides" "# PSMs" "# Unique Peptides" "# AAs" "MW [kDa]" "calc. pI" "Score Sequest HT: Sequest HT" "# Peptides (by Search Engine): Sequest HT" "Biological Process" "Cellular Component" "Molecular Function" "Pfam IDs" "Entrez Gene ID" "Ensembl Gene ID" "Gene Symbol" "Gene ID" "WikiPathways" "Reactome Pathways" "# Protein Pathway Groups" "# Razor Peptides" "Abundance Ratio: (127N, 54C) / (126, 54C)" "Abundance Ratio: (127C, 54C) / (126, 54C)" "Abundance Ratio: (128N, 54C) / (126, 54C)" "Abundance Ratio: (128C, 54C) / (126, 54C)" "Abundance Ratio: (129N, 54C) / (126, 54C)" "Abundance Ratio: (129C, 54C) / (126, 54C)" "Abundance Ratio: (130N, 54C) / (126, 54C)" "Abundance Ratio: (130C, 54C) / (126, 54C)" "Abundance Ratio: (131, 54C) / (126, 54C)" "Abundances (Grouped): 126, 54C" "Abundances (Grouped): 127N, 54C" "Abundances (Grouped): 127C, 54C" "Abundances (Grouped): 128N, 54C" "Abundances (Grouped): 128C, 54C" "Abundances (Grouped): 129N, 54C" "Abundances (Grouped): 129C, 54C" "Abundances (Grouped): 130N, 54C" "Abundances (Grouped): 130C, 54C" "Abundances (Grouped): 131, 54C" "Abundances (Grouped) CV [%]: 126, 54C" "Abundances (Grouped) CV [%]: 127N, 54C" "Abundances (Grouped) CV [%]: 127C, 54C" "Abundances (Grouped) CV [%]: 128N, 54C" "Abundances (Grouped) CV [%]: 128C, 54C" "Abundances (Grouped) CV [%]: 129N, 54C" "Abundances (Grouped) CV [%]: 129C, 54C" "Abundances (Grouped) CV [%]: 130N, 54C" "Abundances (Grouped) CV [%]: 130C, 54C" "Abundances (Grouped) CV [%]: 131, 54C" "Abundance: F50: 126, Sample, 54C" "Abundance: F50: 127N, Sample, 54C" "Abundance: F50: 127C, Sample, 54C" "Abundance: F50: 128N, Sample, 54C" "Abundance: F50: 128C, Sample, 54C" "Abundance: F50: 129N, Sample, 54C" "Abundance: F50: 129C, Sample, 54C" "Abundance: F50: 130N, Sample, 54C" "Abundance: F50: 130C, Sample, 54C" "Abundance: F50: 131, Sample, 54C" "Abundances Count: F50: 126, Sample, 54C" "Abundances Count: F50: 127N, Sample, 54C" "Abundances Count: F50: 127C, Sample, 54C" "Abundances Count: F50: 128N, Sample, 54C" "Abundances Count: F50: 128C, Sample, 54C" "Abundances Count: F50: 129N, Sample, 54C" "Abundances Count: F50: 129C, Sample, 54C" "Abundances Count: F50: 130N, Sample, 54C" "Abundances Count: F50: 130C, Sample, 54C" "Abundances Count: F50: 131, Sample, 54C" "Found in Sample: [S461] F50: 126, Sample, 54C" "Found in Sample: [S462] F50: 127N, Sample, 54C" "Found in Sample: [S463] F50: 127C, Sample, 54C" "Found in Sample: [S464] F50: 128N, Sample, 54C" "Found in Sample: [S465] F50: 128C, Sample, 54C" "Found in Sample: [S466] F50: 129N, Sample, 54C" "Found in Sample: [S467] F50: 129C, Sample, 54C" "Found in Sample: [S468] F50: 130N, Sample, 54C" "Found in Sample: [S469] F50: 130C, Sample, 54C" "Found in Sample: [S470] F50: 131, Sample, 54C" "# Protein Groups" "Modifications" "2962281166201317424" "False" "High" "IsMasterProtein" "P35579" "Myosin-9 OS=Homo sapiens OX=9606 GN=MYH9 PE=1 SV=4" "0.000" "False" "330.395" "40" "78" "197" "65" "1960" "226.4" "5.60" "530.63" "78" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00063, Pf01576, Pf02736" "4627" "ENSG00000100345" "MYH9" "A8K6E4; hsa:4627; O60805; P35579; Q60FE2; Q86T83" "Primary focal segmental glomerulosclerosis (FSGS); VEGFA-VEGFR2 signaling; Nephrotic syndrome; HDAC6 interactions in the central nervous system" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Signaling by ALK fusions and activated point mutants; RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; CD163 mediating an anti-inflammatory response" "17" "13" "1.055" "1.026" "1.061" "1.035" "1.067" "1.043" "1.014" "1.014" "1.267" "9747.4" "10278.9" "9998.3" "10338.7" "10084.1" "10405.1" "10167.9" "9882.6" "9882.1" "12353.7" "" "" "" "" "" "" "" "" "" "" "5833.3" "5341.6" "5536.8" "4853.8" "4674.2" "5326.6" "4727.8" "4436.7" "5361.5" "12353.7" "61" "61" "61" "61" "61" "61" "61" "61" "61" "61" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7017874985935534894" "False" "High" "IsMasterProtein" "P18206" "Vinculin OS=Homo sapiens OX=9606 GN=VCL PE=1 SV=4" "0.000" "False" "281.293" "45" "52" "202" "52" "1134" "123.7" "5.66" "533.01" "52" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01044" "7414" "ENSG00000035403" "VCL" "hsa:7414; P18206; Q16450; Q5SWX2; Q7Z3B8; Q8IXU7" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; VEGFA-VEGFR2 signaling; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Melanoma; Regulation of actin cytoskeleton" "Platelet degranulation ; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Signaling by ALK fusions and activated point mutants; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "18" "0" "1.011" "1.001" "1.013" "0.979" "0.970" "0.941" "0.978" "0.977" "0.539" "13601.2" "13751.8" "13614.9" "13781.6" "13311.3" "13189.1" "12803.2" "13303.1" "13283.6" "7336.3" "" "" "" "" "" "" "" "" "" "" "8139.6" "7146.3" "7539.6" "6470.1" "6170.0" "6751.8" "5953.2" "5972.3" "7206.9" "7336.3" "45" "45" "45" "45" "45" "45" "45" "45" "45" "45" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5005343800474254733" "False" "High" "IsMasterProtein" "P13796" "Plastin-2 OS=Homo sapiens OX=9606 GN=LCP1 PE=1 SV=6" "0.000" "False" "226.179" "53" "30" "456" "30" "627" "70.2" "5.43" "1144.46" "30" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00036, Pf00307" "3936" "ENSG00000136167" "LCP1" "B2R613; B4DUA0; hsa:3936; P13796; Q5TBN4" "" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "1" "0" "0.976" "0.964" "0.962" "0.959" "0.934" "0.963" "0.934" "0.966" "0.592" "28045.7" "27363.1" "27039.9" "26986.9" "26907.0" "26196.8" "27016.9" "26194.5" "27105.2" "16611.8" "" "" "" "" "" "" "" "" "" "" "16783.8" "14219.6" "14974.1" "12669.7" "12471.9" "13410.8" "12562.3" "11759.8" "14705.7" "16611.8" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5927523368410573672" "False" "High" "IsMasterProtein" "P78527" "DNA-dependent protein kinase catalytic subunit OS=Homo sapiens OX=9606 GN=PRKDC PE=1 SV=3" "0.000" "False" "225.753" "15" "61" "108" "61" "4128" "468.8" "7.12" "276.92" "61" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08163, Pf19704, Pf20502" "5591" "ENSG00000253729" "PRKDC" "hsa:5591; P78527; P78528; Q13327; Q13337; Q14175; Q59H99; Q7Z611; Q96SE6; Q9UME3" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Fas ligand pathway and stress induction of heat shock proteins; Pathways affected in adenoid cystic carcinoma; Non-homologous end joining; Osteoblast differentiation and related diseases; DNA repair pathways, full network; DNA damage response" "E3 ubiquitin ligases ubiquitinate target proteins; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); IRF3-mediated induction of type I IFN" "13" "0" "1.034" "1.044" "1.126" "1.199" "1.178" "1.061" "0.711" "1.079" "5.207" "2677.9" "2768.6" "2795.5" "3014.4" "3210.0" "3155.1" "2842.5" "1904.7" "2890.4" "13943.3" "" "" "" "" "" "" "" "" "" "" "1602.5" "1438.7" "1548.1" "1415.2" "1487.9" "1615.2" "1321.7" "855.1" "1568.2" "13943.3" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-772083225745130744" "False" "High" "IsMasterProtein" "P11142" "Heat shock cognate 71 kDa protein OS=Homo sapiens OX=9606 GN=HSPA8 PE=1 SV=1" "0.000" "False" "218.641" "55" "36" "415" "21" "646" "70.9" "5.52" "1167.90" "36" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00012" "3312" "ENSG00000109971" "HSPA8" "hsa:3312; P11142; Q9H3R6" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Exercise-induced circadian regulation; Measles virus infection; Opioid receptor pathways; Extrafollicular and follicular B cell activation by SARS-CoV-2; 1p36 copy number variation syndrome; HDAC6 interactions in the central nervous system" "AUF1 (hnRNP D0) binds and destabilizes mRNA; Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Attenuation phase; Clathrin-mediated endocytosis; Late endosomal microautophagy; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Regulation of HSF1-mediated heat shock response; Lysosome Vesicle Biogenesis; mRNA Splicing - Major Pathway; CHL1 interactions; Interleukin-4 and Interleukin-13 signaling; GABA synthesis, release, reuptake and degradation; Lipophagy; Chaperone Mediated Autophagy; Protein methylation; Respiratory syncytial virus genome transcription" "27" "14" "0.984" "0.968" "0.991" "0.948" "0.929" "0.928" "0.951" "0.958" "0.675" "26746.4" "26320.4" "25883.3" "26506.4" "25359.4" "24836.3" "24807.3" "25434.0" "25609.7" "18044.6" "" "" "" "" "" "" "" "" "" "" "16006.2" "13677.7" "14333.6" "12444.1" "11754.6" "12714.3" "11534.9" "11418.4" "13894.4" "18044.6" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3819136565778515185" "False" "High" "IsMasterProtein" "P13639" "Elongation factor 2 OS=Homo sapiens OX=9606 GN=EEF2 PE=1 SV=4" "0.000" "False" "215.868" "40" "33" "277" "32" "858" "95.3" "6.83" "738.95" "33" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "1938" "ENSG00000167658" "EEF2" "A0A384N6H1; B2RMP5; D6W618; hsa:1938; P13639; Q58J86" "Translation factors; AMP-activated protein kinase signaling; Brain-derived neurotrophic factor (BDNF) signaling pathway; IL-18 signaling pathway" "Neutrophil degranulation; Protein methylation; Uptake and function of diphtheria toxin; Peptide chain elongation; Synthesis of diphthamide-EEF2" "9" "1" "0.964" "0.955" "0.967" "0.917" "0.977" "0.908" "0.988" "0.954" "0.592" "24083.0" "23205.2" "22988.8" "23285.8" "22084.7" "23527.6" "21878.8" "23789.2" "22974.3" "14256.0" "" "" "" "" "" "" "" "" "" "" "14412.3" "12058.9" "12730.7" "10932.1" "10236.7" "12044.4" "10173.2" "10679.9" "12464.5" "14256.0" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-174490317750568225" "False" "High" "IsMasterProtein" "Cont_P60712" "Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1" "0.000" "True" "208.453" "63" "21" "633" "8" "375" "41.7" "5.48" "1724.97" "21" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "100011313; 100011351; 100033878; 100078865; 100135470; 100173832; 100303677; 100654618; 100689477; 100919051; 101026869; 101098507; 101375328; 101813373; 101844587; 101941176; 101958638; 102030392; 102041442; 102067189; 102179831; 102286048; 102386754; 102744309; 102772396; 102884469; 103050159; 103077223; 103115297; 103197222; 105077471; 105294565; 105497365; 105551087; 105719490; 105868294; 105990935; 106497948; 107155983; 107515934; 108496585; 108538237; 109314696; 109380220; 109700700; 11461; 280979; 396526; 403580; 414396; 443052; 450133; 574285; 60; 81822" "ENSABRG00000002004; ENSACOG00000001373; ENSACUG00000014525; ENSAMEG00000019137; ENSAMEG00000025519; ENSAMEG00000030859; ENSANAG00000024575; ENSAPLG00020013590; ENSBIXG00000014387; ENSBIXG00005017151; ENSBJAG00000012824; ENSBOBG00000008860; ENSBTAG00000026199; ENSCABG00000005869; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCAFG00805000771; ENSCCEG00000022540; ENSCCNG00000030119; ENSCGRG00001015781; ENSCHIG00000013316; ENSCJAG00000074750; ENSCJAG00000083114; ENSCLAG00000013196; ENSCMUG00000004054; ENSCPBG00000020809; ENSCPGG00000001752; ENSCPOG00000013467; ENSCPRG00005016203; ENSCPVG00000014059; ENSCSRG00000014125; ENSCUSG00005013766; ENSDLEG00000020930; ENSFALG00000013828; ENSFCAG00000006788; ENSFTIG00000005623; ENSG00000075624; ENSGAGG00000004381; ENSGEVG00005007981; ENSGGOG00000001133; ENSJHYG00000006128; ENSJJAG00000018929; ENSLCNG00005020599; ENSMCSG00000014736; ENSMICG00000002791; ENSMLEG00000038914; ENSMMMG00000007553; ENSMMNG00015004465; ENSMMSG00000018023; ENSMMUG00000011153; ENSMNEG00000033949; ENSMODG00000002647; ENSMPUG00000016612; ENSMUGG00000013478; ENSMUNG00000007311; ENSMUSG00000029580; ENSNVIG00000005620; ENSOANG00000007716; ENSOARG00020008714; ENSOSUG00000006211; ENSPANG00000015700; ENSPCEG00000013440; ENSPCLG00000014414; ENSPCTG00005017252; ENSPEMG00000012952; ENSPLOG00000015512; ENSPPYG00000017336; ENSPSTG00000003558; ENSPTEG00000021167; ENSPTRG00000018890; ENSPTXG00000006649; ENSRBIG00000014104; ENSRFEG00010011816; ENSRNOG00000034254; ENSRNOG00055011660; ENSRNOG00060020294; ENSRNOG00065000139; ENSSBOG00000033859; ENSSHAG00000029431; ENSSHBG00005009495; ENSSOCG00000011957; ENSSSCG00000007585; ENSSSCG00005020690; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSUG00005004355; ENSSTOG00000014797; ENSSVLG00005024720; ENSTGEG00000001941; ENSTMTG00000013939; ENSVKKG00000006783; ENSVURG00010018277; ENSZALG00000007655; ENSZLMG00000002642" "Actb; ACTB; Actb_0; ACTL8; LOC101872991; LOC106497948; LOC111145734; LOC112063645; LOC117800408; LOC118142876; PS1TP5BP1" "A0A096NAA6; A0A098M1X5; A0A0B6VJU7; A0A0B8RRU9; A0A0B8RTY2; A0A1D9CFN7; A0A1S2ZVA4; A0A1S3FRD3; A0A1U7Q273; A0A1W7RJQ3; A0A218UWT5; A0A226NJ42; A0A250YGN4; A0A2D4GG12; A0A2J8KJN5; A0A2J8RAH6; A0A2K5CXD5; A0A2K5ZNV7; A0A2K6C9L8; A0A2K6JVX9; A0A2K6UUH3; A0A2P4SFV3; A0A2U3VHD6; A0A2U3XSJ3; A0A2Y9GE45; A0A2Y9JFQ8; A0A2Y9MFS3; A0A2Y9S868; A0A340WEU6; A0A341CY14; A0A384AHN3; A0A3Q7NCZ0; A0A452EGB1; A0A452GTY2; A0A4D9ENE9; A0A4W2DYQ2; A0A4X2LSI7; A0A5E4C6E9; A0A5J5MXV1; A0A5N3VUL9; A0A5N4CXK3; A0A663NBJ0; A0A667IZV1; A0A669QC85; A0A670YBF6; A0A671EW41; A0A672U7D6; A0A673TCM5; A0A674JEF6; A0A6B0SBF2; A0A6B2F1I3; A0A6B2FBI6; A0A6I9HGD1; A0A6J0H3K7; A0A6J0VYA4; A0A6J1Y0U5; A0A6J2ER79; A0A6J2G0V3; A0A6J2MYQ0; A0A6J3AFQ7; A0A6J3DTG2; A0A6J3GBY8; A0A6J3PXY9; A0A6P3QDF4; A0A6P5M7F0; A0A6P5PSI5; A0A6P9D9Q3; A0A7J7X8Z4; A0A7J8FJ79; A0A7J8I7K0; A0A7K4LHI1; A0A7K4PGF5; A0A7K4QS53; A0A7K4T128; A0A7K4TT29; A0A7K4VIP3; A0A7K4WM66; A0A7K4XNG5; A0A7K4Z9S9; A0A7K5AA34; A0A7K5AS89; A0A7K5BQ55; A0A7K5FSS5; A0A7K5H4P8; A0A7K5I2U8; A0A7K5K1W1; A0A7K5L347; A0A7K5MV66; A0A7K5NYG3; A0A7K5PUR4; A0A7K5QKD4; A0A7K5SEW2; A0A7K5SN56; A0A7K5UCA8; A0A7K5V0T3; A0A7K5W0A4; A0A7K5XZZ2; A0A7K5YRX7; A0A7K5ZQ33; A0A7K6AXY2; A0A7K6BYL2; A0A7K6FAZ8; A0A7K6H213; A0A7K6K8T2; A0A7K6M1I6; A0A7K6NUL4; A0A7K6QDF5; A0A7K6RH22; A0A7K6TM80; A0A7K6VD36; A0A7K6W7N1; A0A7K6X5J8; A0A7K6YU38; A0A7K7C2G9; A0A7K7EJS7; A0A7K7FS46; A0A7K7GD18; A0A7K7IBW8; A0A7K7K4W1; A0A7K7KKG3; A0A7K7MQH8; A0A7K7MV68; A0A7K7PD37; A0A7K7QM76; A0A7K7SE36; A0A7K7SKG2; A0A7K7VCN0; A0A7K7W887; A0A7K7XYY4; A0A7K7YKB8; A0A7K8CFW2; A0A7K8EJC7; A0A7K8FS78; A0A7K8G222; A0A7K8IUQ2; A0A7K8JZV4; A0A7K8LPI3; A0A7K8NBM6; A0A7K8PNA5; A0A7K8Q6L8; A0A7K8RIG2; A0A7K8SZY6; A0A7K8UAQ8; A0A7K8VV48; A0A7K8WC57; A0A7K8XP00; A0A7K8YCU6; A0A7K9A6Q1; A0A7K9CAW4; A0A7K9CTY4; A0A7K9E1U2; A0A7K9FBL7; A0A7K9GU20; A0A7K9HIF7; A0A7K9J0P9; A0A7K9JQ87; A0A7K9LVG6; A0A7K9R4T1; A0A7K9RUC2; A0A7K9T1K6; A0A7K9TJU9; A0A7K9VM54; A0A7K9W8F9; A0A7K9XJP5; A0A7K9YTX8; A0A7L0B981; A0A7L0CFC2; A0A7L0DK08; A0A7L0EE55; A0A7L0FB96; A0A7L0GQU8; A0A7L0IUJ7; A0A7L0K254; A0A7L0L680; A0A7L0MVK5; A0A7L0NBG6; A0A7L0Q6H1; A0A7L0RLK8; A0A7L0TBQ4; A0A7L0UF87; A0A7L0WJD4; A0A7L0ZXX6; A0A7L1D3E3; A0A7L1EEL1; A0A7L1EWI9; A0A7L1GDD0; A0A7L1I1H5; A0A7L1IUB6; A0A7L1K0S4; A0A7L1L6I1; A0A7L1MJS1; A0A7L1N7E9; A0A7L1QY43; A0A7L1R9N1; A0A7L1TFJ1; A0A7L1USL1; A0A7L1X2N1; A0A7L1YHH8; A0A7L1ZA36; A0A7L2AFK2; A0A7L2CBA6; A0A7L2DI04; A0A7L2E5K5; A0A7L2ETQ7; A0A7L2GZ90; A0A7L2HLP4; A0A7L2JI84; A0A7L2K9F9; A0A7L2LSR8; A0A7L2MKA1; A0A7L2NWG1; A0A7L2Q5Z6; A0A7L2TKF5; A0A7L2UQP2; A0A7L2WPM1; A0A7L3AB48; A0A7L3AEQ2; A0A7L3CBV1; A0A7L3GBT6; A0A7L3H4H6; A0A7L3I6Y5; A0A7L3KV16; A0A7L3L3C1; A0A7L3M5B9; A0A7L3NFE1; A0A7L3PPT4; A0A7L3QID2; A0A7L3RPI2; A0A7L3ST79; A0A7L3U378; A0A7L3VAR1; A0A7L3W396; A0A7L3X8C9; A0A7L3Z0M0; A0A7L4AJ46; A0A7L4BIP7; A0A7L4CC84; A0A7L4DQB0; A0A7L4EP40; A0A7L4HN55; A0A7L4J9W9; A0A7M4FIE6; A0A7N4PW14; A0A7T6ZK12; A0A811Z8F1; A0A850TFQ9; A0A850V5R2; A0A850W4N7; A0A850XKN3; A0A850YK23; A0A851A5U4; A0A851B4R4; A0A851CTC7; A0A851D320; A0A851E8C6; A0A851F1A8; A0A851JVZ7; A0A851K2P6; A0A851LU60; A0A851P5P0; A0A851R2P6; A0A851S6S6; A0A851T4V4; A0A851U0I3; A0A851VRP0; A0A851WCV5; A0A851Y321; A0A851Z9B4; A0A852A4Z3; A0A852AR86; A0A852BQ86; A0A852DLV7; A0A852E4W4; A0A852G2S2; A0A852L7H9; A0A852LWU6; A0A852MIU4; A0A852P924; A0A8B6ZZ93; A0A8B7FY80; A0A8B7JWS2; A0A8B7QXR8; A0A8B8VBY0; A0A8B9BC47; A0A8B9EY57; A0A8B9TCS0; A0A8C0BMH3; A0A8C0GIN8; A0A8C0IEG6; A0A8C0VMY6; A0A8C2VXZ2; A0A8C3I6V8; A0A8C3J5G4; A0A8C3QCS8; A0A8C3SWN5; A0A8C3V1H9; A0A8C4U9L8; A0A8C4W3F9; A0A8C5IQ83; A0A8C5L3Y8; A0A8C5UI70; A0A8C5Z473; A0A8C6AVT7; A0A8C6E309; A0A8C6J2B6; A0A8C7ELL8; A0A8C8AQ23; A0A8C8SAX1; A0A8C8TJI2; A0A8C9D802; A0A8C9EU06; A0A8C9HDT2; A0A8D0FEG6; A0A8D2DXS1; A0A8D2E312; A0A8D2J5F6; A0A8D2QDJ6; A0A8D2QMT1; A0A8I3W1I0; A0A8J4I2Z8; A0A8J4N6K5; A0A8J4NKS0; A0A8J4P196; A0A8J4U9Z8; A0A8K0BW04; A0A8K1GFZ5; A0A8M1G7Q7; A0A8S9EM85; A0A8V5H9G0; A0A973YLC1; A0A9F2R4N2; A0A9W2UUK2; A0A9W3F4H2; A0AA35L9Q0; A0AA40H6S4; A0AA40LS06; A5D961; A5PKA1; A6K1N6; aam:106497948; aful:116495117; aju:106984514; asn:102386754; B2RRX1; bacu:103015338; bom:102286048; bta:280979; ccan:109700700; cfa:403580; cfr:102514032; cpic:101941176; cpoc:100135470; cpoo:109314696; D5MU85; D7RIF5; dle:111170344; dord:105990935; ecb:100033878; elk:111145734; F6TIK4; F6UDX9; F7DIB7; fab:101813373; fca:101098507; G1MLH3; G3GVD0; G3QFP0; G8HY07; gfr:102041442; gga:396526; hai:109380220; hsa:60; I3MNL1; J3S3X5; J7H0T4; L5L2F8; L5LSF7; lav:100654618; lve:103077223; lww:102744309; M3WRZ7; M3YYU9; M7B7E7; maua:101844587; mcal:110295381; mcc:574285; mdo:100011313; mdo:100011351; mleu:105551087; mmu:11461; mmur:105868294; mni:105497365; mpuf:101686268; myd:102772396; nasi:112412020; nsu:110572001; O18840; oaa:100078865; oro:101375328; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pale:102884469; panu:101026869; pbi:103050159; pcad:112063645; pcw:110223114; pdic:114509151; pgut:117676791; pon:100173832; ptr:450133; pvp:105294565; Q11209; Q11211; Q1KLZ0; Q25PW9; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q58J72; Q5R1X3; Q5R582; Q5R6G0; Q5W9H6; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; R0LHA7; ray:107515934; rbb:108538237; rno:81822; S9YTS3; sbq:101037287; shr:100919051; ssc:414396; T1DP26; U3FXK3; U3KHC4; umr:103670086; V9P8F4; vpc:102534524; zab:102067189; zca:113932833" "FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling pathway; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion" "EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; RHO GTPases activate IQGAPs; Cell-extracellular matrix interactions; MAP2K and MAPK activation; UCH proteinases; Clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; RHOF GTPase cycle; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; UCH proteinases; RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; EPHB-mediated forward signaling; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by RAF1 mutants; Adherens junctions interactions; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; RHO GTPases Activate Formins; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Adherens junctions interactions; VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; MAP2K and MAPK activation; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; RHO GTPases activate IQGAPs; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; UCH proteinases; Adherens junctions interactions; RHO GTPases activate IQGAPs; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of annular gap junctions" "157" "14" "0.986" "0.970" "0.981" "0.947" "0.943" "0.941" "0.938" "0.983" "0.623" "33287.3" "32833.5" "32295.1" "32663.8" "31512.5" "31380.2" "31321.5" "31234.5" "32734.6" "20748.1" "" "" "" "" "" "" "" "" "" "" "19920.6" "17062.3" "17884.3" "15334.8" "14606.6" "16064.3" "14563.8" "14022.4" "17759.9" "20748.1" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5561612098835552022" "False" "High" "IsMasterProtein" "P38646" "Stress-70 protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPA9 PE=1 SV=2" "0.000" "False" "192.513" "46" "29" "129" "28" "679" "73.6" "6.16" "377.34" "29" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00012" "3313" "ENSG00000113013" "HSPA9" "B2RCM1; hsa:3313; P30036; P31932; P38646; Q1HB43; Q53H23; Q6GU03; Q9BWB7; Q9UC56" "Parkin-ubiquitin proteasomal system pathway; Iron-sulfur cluster biogenesis" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Mitochondrial protein degradation; Mitochondrial protein import; Regulation of HSF1-mediated heat shock response; Cristae formation" "7" "0" "1.002" "0.983" "1.015" "0.985" "0.913" "0.926" "0.948" "0.971" "0.564" "8811.5" "8825.4" "8658.5" "8943.3" "8682.2" "8046.2" "8159.4" "8350.3" "8556.0" "4967.8" "" "" "" "" "" "" "" "" "" "" "5273.2" "4586.2" "4794.9" "4198.7" "4024.4" "4119.0" "3794.0" "3748.8" "4642.0" "4967.8" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2220837361715177214" "False" "High" "IsMasterProtein" "P08238" "Heat shock protein HSP 90-beta OS=Homo sapiens OX=9606 GN=HSP90AB1 PE=1 SV=4" "0.000" "False" "192.478" "43" "29" "297" "17" "724" "83.2" "5.03" "752.47" "29" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "3326" "ENSG00000096384" "HSP90AB1" "B2R5P0; hsa:3326; P08238; Q5T9W7; Q9NQW0; Q9NTK6" "Nuclear receptors meta-pathway; NRF2 pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "The role of GTSE1 in G2/M progression after G2 checkpoint; Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; Potential therapeutics for SARS; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Aryl hydrocarbon receptor signalling; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; DDX58/IFIH1-mediated induction of interferon-alpha/beta; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; RHOBTB2 GTPase cycle; Chaperone Mediated Autophagy; HSF1 activation; Attenuation phase; Uptake and function of diphtheria toxin; Assembly and release of respiratory syncytial virus (RSV) virions; Respiratory syncytial virus genome replication" "25" "0" "1.113" "1.221" "1.139" "1.187" "1.195" "1.227" "0.895" "1.233" "4.787" "4992.6" "5556.5" "6096.3" "5687.4" "5925.2" "5965.3" "6125.9" "4470.2" "6156.1" "23897.4" "" "" "" "" "" "" "" "" "" "" "2987.8" "2887.5" "3376.0" "2670.1" "2746.4" "3053.8" "2848.4" "2006.9" "3339.9" "23897.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6488855965708197639" "False" "High" "IsMasterProtein" "P14618" "Pyruvate kinase PKM OS=Homo sapiens OX=9606 GN=PKM PE=1 SV=4" "0.000" "False" "189.951" "58" "29" "326" "27" "531" "57.9" "7.84" "815.82" "29" "cell organization and biogenesis;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00224, Pf02887" "5315" "ENSG00000067225" "PKM" "A6NFK3; B2R5N8; B3KRY0; B4DFX8; B4DUU6; hsa:5315; P14618; P14786; Q53GK4; Q96E76; Q9BWB5; Q9UCV6; Q9UPF2" "Photodynamic therapy-induced HIF-1 survival signaling; Amino acid metabolism; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Neutrophil degranulation" "10" "2" "0.971" "0.952" "1.020" "0.926" "1.006" "0.943" "1.021" "0.950" "0.561" "21947.9" "21306.3" "20894.8" "22397.3" "20331.5" "22075.6" "20695.1" "22413.1" "20859.2" "12312.0" "" "" "" "" "" "" "" "" "" "" "13134.6" "11072.1" "11571.1" "10514.9" "9424.0" "11301.0" "9622.8" "10062.2" "11317.0" "12312.0" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6896953880380314494" "False" "High" "IsMasterProtein" "P55072" "Transitional endoplasmic reticulum ATPase OS=Homo sapiens OX=9606 GN=VCP PE=1 SV=4" "0.000" "False" "187.593" "45" "34" "137" "34" "806" "89.3" "5.26" "384.11" "34" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00004, Pf02359, Pf02933, Pf17862" "7415" "ENSG00000165280" "VCP" "B2R5T8; P55072; Q0V924; Q2TAI5; Q969G7; Q9UCD5; V9HW80" "Alstrom syndrome; Clock-controlled autophagy in bone metabolism; HDAC6 interactions in the central nervous system" "Aggrephagy; Neutrophil degranulation; HSF1 activation; ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; Neddylation; KEAP1-NFE2L2 pathway; RHOH GTPase cycle; E3 ubiquitin ligases ubiquitinate target proteins; Attachment and Entry; Attachment and Entry; Ovarian tumor domain proteases; Josephin domain DUBs; Protein methylation; Translesion Synthesis by POLH; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "21" "0" "0.925" "0.933" "0.934" "0.926" "0.895" "0.936" "0.884" "0.901" "0.558" "7946.6" "7351.8" "7417.5" "7425.9" "7358.9" "7115.7" "7434.3" "7028.0" "7160.8" "4436.4" "" "" "" "" "" "" "" "" "" "" "4755.6" "3820.5" "4107.6" "3486.3" "3411.0" "3642.7" "3456.8" "3155.2" "3885.1" "4436.4" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7065009906831580898" "False" "High" "IsMasterProtein" "P07900" "Heat shock protein HSP 90-alpha OS=Homo sapiens OX=9606 GN=HSP90AA1 PE=1 SV=5" "0.000" "False" "185.351" "41" "30" "229" "18" "732" "84.6" "5.02" "610.97" "30" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "3320" "ENSG00000080824" "HSP90AA1" "A8K500; B3KPJ9; hsa:3320; P07900; Q2PP14; Q5CAQ6; Q5CAQ7; Q9BVQ5" "Nucleotide-binding oligomerization domain (NOD) pathway; TNF-alpha signaling pathway; Corticotropin-releasing hormone signaling pathway; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Aryl hydrocarbon receptor pathway; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced AP-1 survival signaling; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Th17 cell differentiation pathway; HDAC6 interactions in the central nervous system" "Regulation of actin dynamics for phagocytic cup formation; Potential therapeutics for SARS; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Neutrophil degranulation; vRNP Assembly; Estrogen-dependent gene expression; Regulation of necroptotic cell death; Interleukin-4 and Interleukin-13 signaling; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Sema3A PAK dependent Axon repulsion; DDX58/IFIH1-mediated induction of interferon-alpha/beta; PIWI-interacting RNA (piRNA) biogenesis; VEGFR2 mediated vascular permeability; RHOBTB2 GTPase cycle; Chaperone Mediated Autophagy; HSF1 activation; Attenuation phase; eNOS activation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Uptake and function of diphtheria toxin; Constitutive Signaling by Overexpressed ERBB2; Assembly and release of respiratory syncytial virus (RSV) virions; Respiratory syncytial virus genome replication; Scavenging by Class F Receptors; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "71" "11" "1.082" "1.163" "1.163" "1.186" "1.167" "1.191" "1.001" "1.199" "3.562" "8760.5" "9482.9" "10187.4" "10192.7" "10393.4" "10225.1" "10430.9" "8770.2" "10501.0" "31206.0" "" "" "" "" "" "" "" "" "" "" "5242.7" "4927.9" "5641.6" "4785.2" "4817.5" "5234.5" "4850.1" "3937.3" "5697.2" "31206.0" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6866488294459179487" "False" "High" "IsMasterProtein" "Q8NFC6" "Biorientation of chromosomes in cell division protein 1-like 1 OS=Homo sapiens OX=9606 GN=BOD1L1 PE=1 SV=2" "0.000" "False" "181.671" "18" "44" "59" "44" "3051" "330.3" "5.08" "152.76" "44" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "" "Pf05205" "259282" "ENSG00000038219" "BOD1L1" "hsa:259282; Q6P0M8; Q8NFC6; Q96AL1; Q9H6G0; Q9NTD6; Q9P2L9" "" "Formation of WDR5-containing histone-modifying complexes" "1" "0" "1.044" "1.014" "1.041" "1.041" "0.994" "1.020" "1.038" "1.003" "0.571" "2001.4" "2088.5" "2029.5" "2084.4" "2083.4" "1990.2" "2042.2" "2078.3" "2007.1" "1143.6" "" "" "" "" "" "" "" "" "" "" "1197.7" "1085.3" "1123.9" "978.6" "965.7" "1018.9" "949.6" "933.1" "1088.9" "1143.6" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5619484675981056092" "False" "High" "IsMasterProtein" "P10809" "60 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPD1 PE=1 SV=2" "0.000" "False" "180.487" "66" "31" "222" "31" "573" "61.0" "5.87" "616.97" "31" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00118" "3329" "ENSG00000144381" "HSPD1" "B2R5M6; B7Z712; hsa:3329; P10809; Q38L19; Q9UCR6" "Apoptosis-related network due to altered Notch3 in ovarian cancer; 8p23.1 copy number variation syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways" "Mitochondrial protein degradation; Mitochondrial protein import; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation" "6" "0" "0.945" "0.918" "0.940" "0.974" "0.921" "0.986" "0.956" "0.942" "0.581" "19302.1" "18248.0" "17724.3" "18152.1" "18795.1" "17780.7" "19033.1" "18455.5" "18176.8" "11212.6" "" "" "" "" "" "" "" "" "" "" "11551.2" "9482.8" "9815.3" "8522.0" "8711.9" "9102.4" "8850.0" "8285.4" "9861.7" "11212.6" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8533826193911874289" "False" "High" "IsMasterProtein" "Q86VP6" "Cullin-associated NEDD8-dissociated protein 1 OS=Homo sapiens OX=9606 GN=CAND1 PE=1 SV=2" "0.000" "False" "179.677" "33" "39" "162" "39" "1230" "136.3" "5.78" "417.02" "39" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf08623, Pf13513" "55832" "ENSG00000111530" "CAND1" "B2RAU3; hsa:55832; O94918; Q6PIY4; Q86VP6; Q8NDJ4; Q96JZ9; Q96T19; Q9BTC4; Q9H0G2; Q9P0H7; Q9UF85" "Endoderm differentiation" "Neutrophil degranulation; Neddylation; Iron uptake and transport" "4" "0" "0.986" "0.951" "0.983" "0.941" "1.007" "0.973" "1.050" "1.016" "0.649" "10612.5" "10461.9" "10091.6" "10431.1" "9989.1" "10683.0" "10330.4" "11138.5" "10787.2" "6891.5" "" "" "" "" "" "" "" "" "" "" "6351.0" "5436.7" "5588.5" "4897.1" "4630.1" "5468.9" "4803.4" "5000.5" "5852.5" "6891.5" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3453697574232543386" "False" "High" "IsMasterProtein" "O43707" "Alpha-actinin-4 OS=Homo sapiens OX=9606 GN=ACTN4 PE=1 SV=2" "0.000" "False" "179.144" "44" "35" "96" "35" "911" "104.8" "5.44" "263.43" "35" "cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00307, Pf00435, Pf08726" "81" "ENSG00000130402; ENSG00000282844" "ACTN4" "A4K467; D6PXK4; hsa:81; O43707; O76048" "Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Striated muscle contraction pathway; Ebola virus infection in host; Nephrotic syndrome; Alstrom syndrome" "Platelet degranulation ; Nephrin family interactions" "9" "0" "1.024" "1.031" "1.014" "0.945" "0.962" "0.958" "1.010" "1.015" "0.626" "6829.1" "6992.0" "7041.9" "6927.5" "6451.4" "6571.2" "6542.9" "6897.4" "6933.5" "4272.4" "" "" "" "" "" "" "" "" "" "" "4086.8" "3633.5" "3899.6" "3252.3" "2990.3" "3363.9" "3042.3" "3096.5" "3761.7" "4272.4" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-256091368978195991" "False" "High" "IsMasterProtein" "Q32MZ4" "Leucine-rich repeat flightless-interacting protein 1 OS=Homo sapiens OX=9606 GN=LRRFIP1 PE=1 SV=2" "0.000" "False" "168.028" "39" "27" "56" "26" "808" "89.2" "4.65" "183.03" "27" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09738" "9208" "ENSG00000124831" "LRRFIP1" "E9PGZ2; hsa:9208; O75766; O75799; Q32MZ4; Q32MZ5; Q53T49; Q6PKG2; Q9Y607" "IL-18 signaling pathway; 2q37 copy number variation syndrome" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production" "5" "1" "0.940" "0.916" "0.891" "0.986" "0.904" "1.002" "0.961" "0.852" "0.450" "4148.0" "3898.6" "3799.8" "3694.4" "4088.2" "3749.1" "4157.5" "3986.9" "3532.1" "1866.2" "" "" "" "" "" "" "" "" "" "" "2482.4" "2025.9" "2104.2" "1734.4" "1895.0" "1919.3" "1933.2" "1789.9" "1916.3" "1866.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1034815253104013464" "False" "High" "IsMasterProtein" "P50990" "T-complex protein 1 subunit theta OS=Homo sapiens OX=9606 GN=CCT8 PE=1 SV=4" "0.000" "False" "166.367" "53" "29" "156" "29" "548" "59.6" "5.60" "443.63" "29" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00118" "10694" "ENSG00000156261; ENSG00000291533" "CCT8" "A6NN54; B4DEM7; B4DQH4; hsa:10694; P50990; Q4VBP8" "16p11.2 proximal deletion syndrome" "Neutrophil degranulation; Association of TriC/CCT with target proteins during biosynthesis; Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "8" "0" "0.978" "0.959" "0.999" "0.948" "0.987" "0.983" "1.008" "0.976" "0.686" "12765.6" "12483.3" "12237.3" "12756.6" "12106.7" "12602.8" "12554.1" "12871.3" "12458.8" "8758.5" "" "" "" "" "" "" "" "" "" "" "7639.5" "6487.1" "6776.7" "5988.9" "5611.7" "6451.7" "5837.4" "5778.4" "6759.4" "8758.5" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4357852675593899782" "False" "High" "IsMasterProtein" "P25205" "DNA replication licensing factor MCM3 OS=Homo sapiens OX=9606 GN=MCM3 PE=1 SV=3" "0.000" "False" "163.324" "50" "37" "118" "37" "808" "90.9" "5.77" "300.03" "37" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4172" "ENSG00000112118" "MCM3" "B4DWW4; hsa:4172; P25205; Q92660; Q9BTR3; Q9NUE7" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "11" "0" "0.979" "0.949" "1.041" "1.028" "1.054" "1.027" "1.079" "1.048" "0.994" "6280.3" "6147.6" "5958.6" "6536.3" "6457.4" "6618.2" "6446.9" "6774.9" "6583.1" "6244.5" "" "" "" "" "" "" "" "" "" "" "3758.4" "3194.7" "3299.7" "3068.6" "2993.1" "3388.0" "2997.7" "3041.5" "3571.6" "6244.5" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-823981804521467878" "False" "High" "IsMasterProtein" "P46013" "Proliferation marker protein Ki-67 OS=Homo sapiens OX=9606 GN=MKI67 PE=1 SV=2" "0.000" "False" "160.766" "18" "42" "50" "42" "3256" "358.5" "9.45" "134.47" "42" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00498, Pf08065, Pf15276" "4288" "ENSG00000148773" "MKI67" "hsa:4288; P46013; Q5VWH2" "Primary focal segmental glomerulosclerosis (FSGS)" "" "1" "0" "1.096" "0.982" "0.959" "0.933" "0.965" "0.962" "1.006" "0.981" "0.766" "1864.6" "2044.0" "1831.2" "1788.3" "1739.5" "1799.4" "1794.0" "1875.0" "1830.1" "1427.6" "" "" "" "" "" "" "" "" "" "" "1115.9" "1062.2" "1014.1" "839.6" "806.3" "921.2" "834.2" "841.7" "992.9" "1427.6" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2015185769260426388" "False" "High" "IsMasterProtein" "P53396" "ATP-citrate synthase OS=Homo sapiens OX=9606 GN=ACLY PE=1 SV=3" "0.000" "False" "157.176" "33" "34" "135" "34" "1101" "120.8" "7.33" "377.14" "34" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00285, Pf00549, Pf02629, Pf16114" "47" "ENSG00000131473" "ACLY" "B4DIM0; B4E3P0; hsa:47; P53396; Q13037; Q9BRL0" "Sterol regulatory element-binding proteins (SREBP) signaling; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Fatty acid biosynthesis; Amino acid metabolism; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer" "Neutrophil degranulation; ChREBP activates metabolic gene expression; Fatty acyl-CoA biosynthesis" "10" "0" "0.980" "0.909" "0.985" "0.965" "0.982" "0.979" "0.976" "0.971" "0.850" "7818.8" "7661.1" "7108.2" "7703.8" "7547.4" "7679.0" "7655.5" "7629.6" "7594.0" "6649.8" "" "" "" "" "" "" "" "" "" "" "4679.1" "3981.2" "3936.4" "3616.8" "3498.3" "3931.1" "3559.6" "3425.2" "4120.1" "6649.8" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5449770128653317074" "False" "High" "IsMasterProtein" "Cont_P15636" "Protease 1 OS=Achromobacter lyticus OX=224 PE=1 SV=1" "0.000" "True" "156.904" "20" "13" "394" "13" "653" "68.1" "7.24" "1338.56" "13" "protein metabolism" "non-structural extracellular" "other molecular function" "Pf01483, Pf18911" "" "" "" "" "" "" "0" "0" "1.037" "1.027" "0.933" "1.053" "1.034" "0.970" "1.100" "1.030" "0.691" "19096.2" "19797.4" "19619.2" "17825.9" "20116.6" "19738.3" "18519.8" "21011.2" "19660.3" "13189.7" "" "" "" "" "" "" "" "" "" "" "11428.0" "10288.0" "10864.7" "8368.8" "9324.4" "10104.5" "8611.3" "9432.8" "10666.6" "13189.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9169618704545618170" "False" "High" "IsMasterProtein" "P04075" "Fructose-bisphosphate aldolase A OS=Homo sapiens OX=9606 GN=ALDOA PE=1 SV=2" "0.000" "False" "155.005" "54" "22" "257" "18" "364" "39.4" "8.09" "784.91" "22" "cell organization and biogenesis;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00274" "226" "ENSG00000149925" "ALDOA" "B4DXI7; hsa:226; P04075; Q6FH76; Q6FI10; Q96B15; Q9BWD9; Q9UCN2" "VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; 16p11.2 proximal deletion syndrome; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "Neutrophil degranulation; Glycolysis; Gluconeogenesis; Platelet degranulation" "11" "3" "0.991" "0.967" "0.979" "0.951" "0.981" "0.933" "1.018" "0.976" "0.515" "22895.6" "22686.9" "22148.3" "22425.5" "21772.3" "22455.3" "21362.9" "23317.3" "22352.9" "11784.7" "" "" "" "" "" "" "" "" "" "" "13701.7" "11789.5" "12265.2" "10528.2" "10091.9" "11495.4" "9933.3" "10468.1" "12127.4" "11784.7" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1119286615561917853" "False" "High" "IsMasterProtein" "P00558" "Phosphoglycerate kinase 1 OS=Homo sapiens OX=9606 GN=PGK1 PE=1 SV=3" "0.000" "False" "152.199" "61" "23" "166" "18" "417" "44.6" "8.10" "443.94" "23" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;cytosol" "kinase activity;other molecular function" "Pf00162" "5230" "ENSG00000102144" "PGK1" "A8K4W6; B7Z7A9; hsa:5230; P00558; Q5J7W1; Q6IBT6; Q8NI87" "Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism" "13" "5" "1.003" "0.944" "1.008" "0.937" "1.011" "0.890" "0.984" "0.920" "0.655" "11858.3" "11897.3" "11192.8" "11958.1" "11116.7" "11985.5" "10551.8" "11670.9" "10912.4" "7771.8" "" "" "" "" "" "" "" "" "" "" "7096.6" "6182.6" "6198.3" "5614.0" "5152.8" "6135.7" "4906.4" "5239.5" "5920.4" "7771.8" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562319574892213792" "False" "High" "IsMasterProtein" "P04406" "Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens OX=9606 GN=GAPDH PE=1 SV=3" "0.000" "False" "151.236" "61" "21" "453" "21" "335" "36.0" "8.46" "1155.84" "21" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00044, Pf02800" "2597" "ENSG00000111640" "GAPDH" "E7EUT4; hsa:2597; P00354; P04406; Q53X65" "Cori cycle; Alzheimer's disease and miRNA effects; HIF1A and PPARG regulation of glycolysis; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; 7q11.23 copy number variation syndrome; Glycolysis in senescence; Alzheimer's disease; Sildenafil treatment; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "Glycolysis; Gluconeogenesis" "16" "0" "1.009" "0.968" "0.972" "0.945" "0.881" "0.999" "0.955" "1.009" "0.534" "28829.5" "29090.1" "27892.9" "28031.7" "27234.3" "25412.1" "28803.9" "27535.6" "29095.2" "15395.8" "" "" "" "" "" "" "" "" "" "" "17252.8" "15117.0" "15446.4" "13160.2" "12623.6" "13009.1" "13393.2" "12361.8" "15785.4" "15395.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6880355764133463335" "False" "High" "IsMasterProtein" "P26358" "DNA (cytosine-5)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=DNMT1 PE=1 SV=2" "0.000" "False" "148.566" "23" "39" "85" "39" "1616" "183.1" "7.75" "238.09" "39" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00145, Pf01426, Pf02008, Pf06464, Pf12047" "1786" "ENSG00000130816" "DNMT1" "A0AV63; B7ZLW6; hsa:1786; P26358; Q9UHG5; Q9ULA2; Q9UMZ6" "Trans-sulfuration pathway; One-carbon metabolism; Retinoblastoma gene in cancer; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency; Spina bifida" "SUMOylation of DNA methylation proteins; NoRC negatively regulates rRNA expression; STAT3 nuclear events downstream of ALK signaling; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; Nuclear events stimulated by ALK signaling in cancer" "13" "0" "1.076" "1.087" "1.140" "1.093" "1.106" "1.115" "1.132" "1.145" "1.022" "4301.9" "4630.6" "4674.4" "4906.3" "4700.7" "4757.6" "4794.7" "4870.7" "4927.0" "4394.8" "" "" "" "" "" "" "" "" "" "" "2574.5" "2406.3" "2588.6" "2303.4" "2178.9" "2435.5" "2229.5" "2186.7" "2673.1" "4394.8" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "682895518506643546" "False" "High" "IsMasterProtein" "P11021" "Endoplasmic reticulum chaperone BiP OS=Homo sapiens OX=9606 GN=HSPA5 PE=1 SV=2" "0.000" "False" "148.474" "43" "26" "123" "23" "654" "72.3" "5.16" "337.37" "26" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "translation activity;other molecular function" "Pf00012" "3309" "ENSG00000044574" "HSPA5" "B0QZ61; hsa:3309; P11021; Q2EF78; Q9NPF1; Q9UK02" "Parkin-ubiquitin proteasomal system pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Photodynamic therapy-induced unfolded protein response; Prion disease pathway; Unfolded protein response; Orexin receptor pathway" "Regulation of HSF1-mediated heat shock response; Platelet degranulation ; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ATF6B (ATF6-beta) activates chaperones; IRE1alpha activates chaperones; PERK regulates gene expression; ATF6 (ATF6-alpha) activates chaperone genes" "14" "0" "1.016" "0.984" "1.017" "0.983" "0.967" "0.971" "1.048" "1.015" "0.605" "4872.1" "4949.8" "4795.3" "4956.1" "4789.5" "4713.6" "4730.6" "5107.1" "4944.1" "2947.0" "" "" "" "" "" "" "" "" "" "" "2915.7" "2572.2" "2655.5" "2326.7" "2220.0" "2413.0" "2199.6" "2292.8" "2682.4" "2947.0" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7479442399663165637" "False" "High" "IsMasterProtein" "Cont_P02769" "Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4" "0.000" "True" "147.206" "49" "29" "99" "28" "607" "69.2" "6.18" "308.09" "29" "stress response;other biological processes" "non-structural extracellular;other cell component" "nucleic acid binding activity;other molecular function" "Pf00273" "280717" "" "ALB" "A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2" "" "" "0" "1" "1.306" "0.940" "1.130" "0.768" "0.903" "1.203" "1.060" "1.093" "0.651" "8186.8" "10694.3" "7693.6" "9251.2" "6288.3" "7391.2" "9850.3" "8676.0" "8950.4" "5332.0" "" "" "" "" "" "" "" "" "" "" "4899.4" "5557.4" "4260.6" "4343.2" "2914.8" "3783.7" "4580.2" "3895.0" "4856.0" "5332.0" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6996937188134376608" "False" "High" "IsMasterProtein" "Q16531" "DNA damage-binding protein 1 OS=Homo sapiens OX=9606 GN=DDB1 PE=1 SV=1" "0.000" "False" "147.182" "29" "32" "118" "32" "1140" "126.9" "5.26" "286.79" "32" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "1642" "ENSG00000167986" "DDB1" "A6NG77; B2R648; B4DG00; hsa:1642; O15176; Q13289; Q16531; Q58F96" "Hippo-Merlin signaling dysregulation; Hepatitis B infection; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER; Dual Incision in GG-NER" "14" "0" "1.002" "0.997" "1.063" "0.987" "1.058" "0.981" "1.129" "1.001" "0.557" "6665.4" "6676.8" "6644.3" "7086.8" "6577.6" "7048.8" "6538.4" "7524.4" "6669.0" "3714.7" "" "" "" "" "" "" "" "" "" "" "3988.9" "3469.7" "3679.4" "3327.1" "3048.8" "3608.5" "3040.2" "3378.0" "3618.2" "3714.7" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2305783293341844831" "False" "High" "IsMasterProtein" "Q14204" "Cytoplasmic dynein 1 heavy chain 1 OS=Homo sapiens OX=9606 GN=DYNC1H1 PE=1 SV=5" "0.000" "False" "143.076" "9" "42" "56" "42" "4646" "532.1" "6.40" "140.12" "42" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf03028, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf17852, Pf18198, Pf18199" "1778" "ENSG00000197102" "DYNC1H1" "B0I1R0; hsa:1778; Q14204; Q6DKQ7; Q8WU28; Q92814; Q9Y4G5" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption; PAFAH1B1 copy number variation" "Separation of Sister Chromatids; Neutrophil degranulation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; COPI-mediated anterograde transport; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "24" "0" "1.031" "1.044" "1.052" "1.075" "1.094" "1.112" "0.742" "1.062" "5.081" "1755.1" "1810.0" "1831.8" "1847.1" "1886.0" "1920.3" "1951.1" "1302.8" "1864.8" "8918.0" "" "" "" "" "" "" "" "" "" "" "1050.3" "940.6" "1014.4" "867.2" "874.2" "983.0" "907.2" "584.9" "1011.7" "8918.0" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4615289327887409645" "False" "High" "IsMasterProtein" "Q9Y490" "Talin-1 OS=Homo sapiens OX=9606 GN=TLN1 PE=1 SV=3" "0.000" "False" "142.885" "15" "36" "59" "36" "2541" "269.6" "6.07" "158.51" "36" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00373, Pf01608, Pf08913, Pf09141, Pf16511, Pf21692" "7094" "ENSG00000137076" "TLN1" "A0A1S5UZ07; A6NMY0; hsa:7094; Q86YD0; Q9NZQ2; Q9UHH8; Q9UPX3; Q9Y490" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; TROP2 regulatory signaling" "Platelet degranulation ; p130Cas linkage to MAPK signaling for integrins; Signaling by BRAF and RAF1 fusions; XBP1(S) activates chaperone genes; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins" "18" "0" "1.090" "1.160" "1.174" "1.230" "1.189" "1.105" "0.746" "1.144" "5.384" "1065.4" "1160.9" "1236.0" "1250.4" "1310.9" "1266.8" "1177.5" "794.6" "1219.1" "5736.4" "" "" "" "" "" "" "" "" "" "" "637.6" "603.3" "684.5" "587.0" "607.6" "648.5" "547.5" "356.7" "661.4" "5736.4" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6252367434931231115" "False" "High" "IsMasterProtein" "P49327" "Fatty acid synthase OS=Homo sapiens OX=9606 GN=FASN PE=1 SV=3" "0.000" "False" "137.790" "16" "34" "76" "34" "2511" "273.3" "6.44" "183.81" "34" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00107, Pf00109, Pf00550, Pf00698, Pf00975, Pf02801, Pf08242, Pf08659, Pf16197, Pf21089, Pf21149" "2194" "ENSG00000169710" "FASN" "hsa:2194; P49327; Q13479; Q16702; Q4LE83; Q6P4U5; Q6SS02; Q969R1; Q96C68; Q96IT0" "AMP-activated protein kinase signaling; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; FOXA2 pathway" "ChREBP activates metabolic gene expression; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Vitamin B5 (pantothenate) metabolism" "18" "0" "1.094" "1.054" "1.132" "1.139" "1.110" "1.192" "0.802" "1.087" "4.623" "2064.4" "2258.3" "2176.5" "2336.0" "2350.6" "2291.4" "2460.1" "1654.9" "2244.9" "9544.4" "" "" "" "" "" "" "" "" "" "" "1235.4" "1173.5" "1205.3" "1096.7" "1089.6" "1173.0" "1143.9" "742.9" "1217.9" "9544.4" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8293079878251606526" "False" "High" "IsMasterProtein" "P14625" "Endoplasmin OS=Homo sapiens OX=9606 GN=HSP90B1 PE=1 SV=1" "0.000" "False" "136.744" "38" "31" "97" "30" "803" "92.4" "4.84" "266.45" "31" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "7184" "ENSG00000166598" "HSP90B1" "hsa:7184; P14625; Q96A97" "Photodynamic therapy-induced unfolded protein response; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; PI3K-Akt signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Interleukin-4 and Interleukin-13 signaling; Trafficking and processing of endosomal TLR; Scavenging by Class A Receptors; ATF6 (ATF6-alpha) activates chaperone genes" "11" "1" "0.978" "0.917" "0.988" "0.967" "0.995" "0.997" "1.039" "1.037" "0.846" "7139.6" "6982.8" "6547.1" "7051.5" "6903.7" "7104.6" "7121.3" "7417.4" "7401.9" "6038.4" "" "" "" "" "" "" "" "" "" "" "4272.6" "3628.7" "3625.7" "3310.5" "3200.0" "3637.0" "3311.3" "3330.0" "4015.9" "6038.4" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3973589334991488607" "False" "High" "IsMasterProtein" "Cont_P04264" "Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6" "0.000" "True" "135.757" "36" "25" "54" "19" "644" "66.0" "8.12" "172.68" "25" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038, Pf16208, Pf16210" "3848" "ENSG00000167768" "KRT1" "B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298" "Corticotropin-releasing hormone signaling pathway" "Formation of the cornified envelope; Neutrophil degranulation" "4" "3" "0.496" "3.521" "0.432" "0.537" "0.590" "0.431" "0.385" "0.989" "1.236" "4089.3" "2027.0" "14400.2" "1767.9" "2196.9" "2413.0" "1760.8" "1574.3" "4044.9" "5052.9" "" "" "" "" "" "" "" "" "" "" "2447.2" "1053.3" "7974.5" "830.0" "1018.3" "1235.3" "818.7" "706.8" "2194.5" "5052.9" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4366334861174983345" "False" "High" "IsMasterProtein" "P68363" "Tubulin alpha-1B chain OS=Homo sapiens OX=9606 GN=TUBA1B PE=1 SV=1" "0.000" "False" "135.613" "53" "19" "157" "1" "451" "50.1" "5.06" "430.93" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00091, Pf03953" "10376" "ENSG00000123416" "TUBA1B" "hsa:10376; P04687; P05209; P68363; Q27I68; Q8WU19" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Allograft rejection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; HCMV Early Events; MHC class II antigen presentation; PKR-mediated signaling; Recycling pathway of L1; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; RHOH GTPase cycle" "36" "15" "1.045" "0.904" "0.968" "1.024" "1.120" "0.989" "1.106" "1.035" "0.926" "8196.5" "8567.6" "7408.9" "7930.6" "8393.1" "9182.1" "8108.6" "9061.7" "8480.6" "7591.3" "" "" "" "" "" "" "" "" "" "" "4905.1" "4452.2" "4102.9" "3723.2" "3890.4" "4700.6" "3770.3" "4068.1" "4601.1" "7591.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2868702294912813046" "False" "High" "IsMasterProtein" "P60174" "Triosephosphate isomerase OS=Homo sapiens OX=9606 GN=TPI1 PE=1 SV=4" "0.000" "False" "135.370" "81" "16" "246" "16" "249" "26.7" "6.90" "722.62" "16" "other metabolic processes" "cytosol" "other molecular function" "Pf00121" "7167" "ENSG00000111669" "TPI1" "B7Z5D8; D3DUS9; hsa:7167; P00938; P60174; Q6FHP9; Q6IS07; Q8WWD0; Q96AG5" "Fatty acid beta-oxidation; Cori cycle; HIF1A and PPARG regulation of glycolysis; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis" "10" "0" "1.005" "1.011" "0.947" "0.939" "0.940" "0.920" "0.971" "0.948" "0.547" "15231.9" "15303.3" "15396.8" "14424.6" "14309.5" "14323.4" "14015.5" "14790.0" "14437.2" "8332.9" "" "" "" "" "" "" "" "" "" "" "9115.4" "7952.5" "8526.4" "6772.0" "6632.7" "7332.5" "6516.9" "6639.8" "7832.8" "8332.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5579729439990208910" "False" "High" "IsMasterProtein" "P06733" "Alpha-enolase OS=Homo sapiens OX=9606 GN=ENO1 PE=1 SV=2" "0.000" "False" "134.343" "54" "20" "223" "10" "434" "47.1" "7.39" "581.88" "20" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00113, Pf03952" "2023" "ENSG00000074800" "ENO1" "B2RD59; hsa:2023; P06733; P22712; Q16704; Q4TUS4; Q53FT9; Q53HR3; Q658M5; Q6GMP2; Q71V37; Q7Z3V6; Q8WU71; Q96GV1; Q9BT62; Q9UCH6; Q9UM55" "Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; IL-18 signaling pathway; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism" "9" "8" "0.986" "0.976" "0.910" "0.912" "0.776" "1.043" "0.867" "1.058" "0.489" "14808.4" "14602.2" "14446.7" "13476.2" "13498.4" "11487.6" "15440.1" "12842.4" "15663.6" "7245.7" "" "" "" "" "" "" "" "" "" "" "8862.0" "7588.2" "8000.2" "6326.7" "6256.8" "5880.8" "7179.3" "5765.5" "8498.1" "7245.7" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3002712347046388220" "False" "High" "IsMasterProtein" "P78371" "T-complex protein 1 subunit beta OS=Homo sapiens OX=9606 GN=CCT2 PE=1 SV=4" "0.000" "False" "133.115" "51" "23" "113" "23" "535" "57.5" "6.46" "297.47" "23" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00118" "10576" "ENSG00000166226" "CCT2" "A8K402; B5BTY7; B7Z243; B7Z7K4; B7ZAT2; hsa:10576; P78371; Q14D36; Q6IAT3" "16p11.2 proximal deletion syndrome" "Neutrophil degranulation; Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; Folding of actin by CCT/TriC" "10" "0" "0.945" "0.924" "0.962" "0.939" "0.955" "0.946" "0.976" "0.913" "0.681" "8875.4" "8385.6" "8204.4" "8537.4" "8335.7" "8479.0" "8396.2" "8661.4" "8099.4" "6044.7" "" "" "" "" "" "" "" "" "" "" "5311.5" "4357.7" "4543.4" "4008.1" "3863.8" "4340.6" "3904.0" "3888.5" "4394.3" "6044.7" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8277375164580502172" "False" "High" "IsMasterProtein" "Q14683" "Structural maintenance of chromosomes protein 1A OS=Homo sapiens OX=9606 GN=SMC1A PE=1 SV=2" "0.000" "False" "129.193" "27" "33" "72" "33" "1233" "143.1" "7.64" "193.31" "33" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "8243" "ENSG00000072501" "SMC1A" "hsa:8243; O14995; Q14683; Q16351; Q2M228" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Pathways affected in adenoid cystic carcinoma; ATM signaling in development and disease ; mRNA processing; Regulation of sister chromatid separation at the metaphase-anaphase transition; Rett syndrome; CAMKK2 pathway; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation; DNA damage response" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Estrogen-dependent gene expression; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "22" "0" "1.058" "0.976" "0.983" "1.030" "1.054" "0.941" "0.920" "0.939" "1.083" "3356.4" "3552.2" "3275.8" "3298.5" "3456.0" "3538.4" "3158.7" "3087.3" "3151.5" "3634.9" "" "" "" "" "" "" "" "" "" "" "2008.6" "1846.0" "1814.1" "1548.5" "1601.9" "1811.4" "1468.7" "1386.0" "1709.8" "3634.9" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3959572878681588940" "False" "High" "IsMasterProtein" "P17987" "T-complex protein 1 subunit alpha OS=Homo sapiens OX=9606 GN=TCP1 PE=1 SV=1" "0.000" "False" "128.295" "42" "20" "113" "20" "556" "60.3" "6.11" "323.21" "20" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00118" "6950" "ENSG00000120438" "TCP1" "E1P5B2; hsa:6950; P17987; Q15556; Q5TCM3" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "8" "0" "0.971" "0.924" "0.985" "0.960" "1.020" "0.956" "1.031" "0.971" "0.683" "6351.9" "6170.9" "5869.3" "6258.9" "6100.6" "6476.4" "6075.4" "6550.0" "6167.3" "4340.0" "" "" "" "" "" "" "" "" "" "" "3801.3" "3206.8" "3250.3" "2938.4" "2827.7" "3315.4" "2824.9" "2940.6" "3346.0" "4340.0" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7224600777690592247" "False" "High" "IsMasterProtein" "P50991" "T-complex protein 1 subunit delta OS=Homo sapiens OX=9606 GN=CCT4 PE=1 SV=4" "0.000" "False" "128.088" "50" "24" "178" "23" "539" "57.9" "7.83" "474.06" "24" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00118" "10575" "ENSG00000115484" "CCT4" "B2R6I3; B7Z8B1; F5H5W3; hsa:10575; O14870; P50991; Q53QP9; Q96C51" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "7" "1" "0.994" "0.959" "1.028" "0.929" "1.004" "0.961" "1.020" "0.951" "0.681" "10476.2" "10411.9" "10042.4" "10767.9" "9729.6" "10515.6" "10068.1" "10682.5" "9959.4" "7136.3" "" "" "" "" "" "" "" "" "" "" "6269.4" "5410.7" "5561.3" "5055.3" "4509.8" "5383.2" "4681.5" "4795.8" "5403.4" "7136.3" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8649453304125061400" "False" "High" "IsMasterProtein" "Q12906" "Interleukin enhancer-binding factor 3 OS=Homo sapiens OX=9606 GN=ILF3 PE=1 SV=3" "0.000" "False" "124.725" "30" "23" "116" "18" "894" "95.3" "8.76" "307.68" "23" "protein metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf07528, Pf20965" "3609" "ENSG00000129351" "ILF3" "A8K6F2; G5E9M5; hsa:3609; O43409; Q12906; Q6P1X1; Q86XY7; Q99544; Q99545; Q9BZH4; Q9BZH5; Q9NQ95; Q9NQ96; Q9NQ97; Q9NQ98; Q9NQ99; Q9NQA0; Q9NQA1; Q9NQA2; Q9NRN2; Q9NRN3; Q9NRN4; Q9UMZ9; Q9UN00; Q9UN84; Q9UNA2" "" "PKR-mediated signaling; Regulation of CDH11 gene transcription" "2" "5" "1.002" "0.992" "1.018" "0.963" "0.996" "0.943" "1.041" "1.015" "0.658" "6828.8" "6840.6" "6772.9" "6949.6" "6575.8" "6800.9" "6439.4" "7109.9" "6931.5" "4490.4" "" "" "" "" "" "" "" "" "" "" "4086.7" "3554.8" "3750.7" "3262.7" "3048.0" "3481.5" "2994.2" "3191.9" "3760.6" "4490.4" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7449371538365957033" "False" "High" "IsMasterProtein" "P12270" "Nucleoprotein TPR OS=Homo sapiens OX=9606 GN=TPR PE=1 SV=3" "0.000" "False" "124.267" "17" "36" "44" "36" "2363" "267.1" "5.02" "121.37" "36" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf07926" "7175" "ENSG00000047410" "TPR" "hsa:7175; P12270; Q15624; Q15655; Q5SWY0; Q99968" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signaling by ALK fusions and activated point mutants" "29" "0" "1.070" "1.208" "1.028" "1.191" "1.049" "0.966" "0.903" "0.976" "1.839" "1274.4" "1363.6" "1539.7" "1310.0" "1517.6" "1336.6" "1231.3" "1151.1" "1244.4" "2344.2" "" "" "" "" "" "" "" "" "" "" "762.7" "708.6" "852.7" "615.0" "703.4" "684.2" "572.5" "516.8" "675.1" "2344.2" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6942352143814958774" "False" "High" "IsMasterProtein" "P49368" "T-complex protein 1 subunit gamma OS=Homo sapiens OX=9606 GN=CCT3 PE=1 SV=4" "0.000" "False" "123.228" "44" "24" "131" "24" "545" "60.5" "6.49" "344.80" "24" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "7203" "ENSG00000163468" "CCT3" "A6NE14; hsa:7203; P49368; Q5SZY1; Q9BR64" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "7" "0" "0.942" "0.890" "0.994" "0.951" "0.952" "0.949" "0.964" "0.931" "0.701" "9464.1" "8911.7" "8418.7" "9403.0" "8997.1" "9006.8" "8981.8" "9123.0" "8812.3" "6633.5" "" "" "" "" "" "" "" "" "" "" "5663.7" "4631.1" "4662.1" "4414.5" "4170.3" "4610.8" "4176.3" "4095.7" "4781.0" "6633.5" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5530158233237029042" "False" "High" "IsMasterProtein" "Q15075" "Early endosome antigen 1 OS=Homo sapiens OX=9606 GN=EEA1 PE=1 SV=2" "0.000" "False" "123.088" "21" "29" "42" "29" "1411" "162.4" "5.68" "122.72" "29" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363" "8411" "ENSG00000102189" "EEA1" "hsa:8411; Q14221; Q15075" "VEGFA-VEGFR2 signaling" "Toll Like Receptor 9 (TLR9) Cascade" "2" "0" "1.178" "1.087" "1.138" "1.164" "1.029" "1.190" "1.155" "1.130" "0.645" "2035.9" "2397.3" "2212.7" "2316.1" "2369.0" "2095.1" "2423.3" "2351.7" "2299.8" "1312.4" "" "" "" "" "" "" "" "" "" "" "1218.4" "1245.8" "1225.4" "1087.3" "1098.1" "1072.6" "1126.8" "1055.8" "1247.8" "1312.4" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "528371413836643526" "False" "High" "IsMasterProtein" "Q92945" "Far upstream element-binding protein 2 OS=Homo sapiens OX=9606 GN=KHSRP PE=1 SV=4" "0.000" "False" "122.747" "32" "25" "107" "21" "711" "73.1" "7.30" "293.07" "25" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf09005" "8570" "ENSG00000088247" "KHSRP" "hsa:8570; O00301; Q59EZ9; Q5U4P6; Q92945; Q9UNT5; Q9UQH5" "Pre-implantation embryo" "ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA" "3" "4" "1.042" "0.986" "1.002" "1.074" "0.935" "1.032" "1.013" "1.009" "0.605" "7273.5" "7578.0" "7174.1" "7290.2" "7813.0" "6802.9" "7507.2" "7368.1" "7341.3" "4403.1" "" "" "" "" "" "" "" "" "" "" "4352.8" "3938.0" "3972.9" "3422.6" "3621.5" "3482.6" "3490.7" "3307.8" "3983.0" "4403.1" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8215909947984891721" "False" "High" "IsMasterProtein" "P27816" "Microtubule-associated protein 4 OS=Homo sapiens OX=9606 GN=MAP4 PE=1 SV=3" "0.000" "False" "122.078" "22" "22" "52" "22" "1152" "120.9" "5.43" "162.76" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00418" "4134" "ENSG00000047849" "MAP4" "P27816; Q13082; Q59FT2; Q68D74; Q6ZUW9; Q86V26; Q96A76; Q96NS9" "Splicing factor NOVA regulated synaptic proteins; 2q37 copy number variation syndrome" "" "2" "0" "1.065" "0.971" "0.973" "0.984" "0.916" "0.972" "1.037" "1.001" "0.527" "3144.4" "3349.5" "3054.8" "3061.1" "3093.0" "2881.3" "3057.4" "3259.3" "3149.1" "1657.7" "" "" "" "" "" "" "" "" "" "" "1881.8" "1740.6" "1691.7" "1437.1" "1433.7" "1475.0" "1421.6" "1463.2" "1708.5" "1657.7" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8785242188080332383" "False" "High" "IsMasterProtein" "P28838" "Cytosol aminopeptidase OS=Homo sapiens OX=9606 GN=LAP3 PE=1 SV=3" "0.000" "False" "121.527" "40" "21" "82" "21" "519" "56.1" "7.93" "251.06" "21" "protein metabolism" "other cell component" "other molecular function" "Pf00883, Pf02789" "51056" "ENSG00000002549" "LAP3" "B3KMQ3; hsa:51056; P28838; Q6IAM6; Q6P0L6; Q9UQE3" "" "" "0" "0" "1.090" "1.021" "1.021" "1.043" "0.901" "1.085" "0.943" "0.995" "0.850" "5567.2" "6068.2" "5681.4" "5685.5" "5804.4" "5016.2" "6038.9" "5248.6" "5541.1" "4729.6" "" "" "" "" "" "" "" "" "" "" "3331.6" "3153.4" "3146.2" "2669.2" "2690.5" "2567.9" "2807.9" "2356.3" "3006.3" "4729.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8012908085941337264" "False" "High" "IsMasterProtein" "Q99832" "T-complex protein 1 subunit eta OS=Homo sapiens OX=9606 GN=CCT7 PE=1 SV=2" "0.000" "False" "121.075" "39" "18" "125" "18" "543" "59.3" "7.65" "344.98" "18" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "10574" "ENSG00000135624" "CCT7" "A8K7E6; A8MWI8; B7WNW9; B7Z4T9; B7Z4Z7; hsa:10574; O14871; Q6FI26; Q99832" "VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; RHOBTB1 GTPase cycle; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC" "9" "0" "0.938" "0.943" "0.966" "0.907" "0.994" "0.945" "0.978" "0.952" "0.691" "8271.8" "7762.9" "7797.9" "7990.4" "7500.2" "8222.6" "7820.3" "8089.8" "7873.3" "5716.6" "" "" "" "" "" "" "" "" "" "" "4950.2" "4034.1" "4318.3" "3751.3" "3476.5" "4209.3" "3636.2" "3631.9" "4271.6" "5716.6" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6718063858029524947" "False" "High" "IsMasterProtein" "P50395" "Rab GDP dissociation inhibitor beta OS=Homo sapiens OX=9606 GN=GDI2 PE=1 SV=2" "0.000" "False" "120.696" "47" "21" "108" "16" "445" "50.6" "6.47" "275.12" "21" "transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "2665" "ENSG00000057608" "GDI2" "hsa:2665; O43928; P50395; Q5SX88; Q9UQM6" "" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs" "2" "4" "1.017" "1.001" "1.014" "0.928" "1.055" "0.887" "1.024" "0.948" "0.710" "7563.3" "7688.3" "7572.3" "7669.6" "7019.5" "7977.2" "6711.9" "7746.1" "7171.5" "5369.0" "" "" "" "" "" "" "" "" "" "" "4526.2" "3995.3" "4193.4" "3600.7" "3253.7" "4083.8" "3120.9" "3477.5" "3890.8" "5369.0" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2050551167936510610" "False" "High" "IsMasterProtein" "Q01813" "ATP-dependent 6-phosphofructokinase, platelet type OS=Homo sapiens OX=9606 GN=PFKP PE=1 SV=2" "0.000" "False" "119.421" "32" "22" "100" "18" "784" "85.5" "7.55" "265.43" "22" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00365" "5214" "ENSG00000067057" "PFKP" "B3KS15; hsa:5214; Q01813; Q5VSR7; Q5VSR8" "Cori cycle; Clear cell renal cell carcinoma pathways; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis" "6" "3" "0.996" "0.933" "1.009" "0.952" "1.079" "0.974" "1.057" "0.954" "0.628" "5326.2" "5302.3" "4969.2" "5372.1" "5072.7" "5745.9" "5185.3" "5628.3" "5080.2" "3344.3" "" "" "" "" "" "" "" "" "" "" "3187.4" "2755.4" "2751.8" "2522.1" "2351.3" "2941.5" "2411.1" "2526.8" "2756.2" "3344.3" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2859585786570282431" "False" "High" "IsMasterProtein" "P08237" "ATP-dependent 6-phosphofructokinase, muscle type OS=Homo sapiens OX=9606 GN=PFKM PE=1 SV=2" "0.000" "False" "118.789" "35" "22" "126" "19" "780" "85.1" "7.99" "322.32" "22" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "kinase activity;other molecular function" "Pf00365" "5213" "ENSG00000152556" "PFKM" "hsa:5213; J3KNX3; P08237; Q16814; Q16815; Q6ZTT1" "Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Insulin signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis" "6" "1" "0.959" "0.921" "1.048" "0.923" "0.971" "0.922" "0.973" "0.906" "0.612" "6534.5" "6266.5" "6019.5" "6847.9" "6030.4" "6347.3" "6022.8" "6357.3" "5922.2" "4000.5" "" "" "" "" "" "" "" "" "" "" "3910.5" "3256.4" "3333.5" "3214.9" "2795.2" "3249.3" "2800.5" "2854.0" "3213.0" "4000.5" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2726683976815450871" "False" "High" "IsMasterProtein" "P00338" "L-lactate dehydrogenase A chain OS=Homo sapiens OX=9606 GN=LDHA PE=1 SV=2" "0.000" "False" "118.161" "45" "17" "283" "16" "332" "36.7" "8.27" "754.42" "17" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "3939" "ENSG00000134333; ENSG00000288299" "LDHA" "B4DKQ2; B7Z5E3; D3DQY3; F8W819; hsa:3939; P00338; Q53G53; Q6IBM7; Q6ZNV1; Q9UDE8; Q9UDE9" "Cori cycle; HIF1A and PPARG regulation of glycolysis; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Amino acid metabolism; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Orexin receptor pathway; CCL18 signaling pathway; Glucose metabolism in triple-negative breast cancer cells; Warburg effect modulated by deubiquitinating enzymes and their substrates; Lactate shuttle in glial cells; Glycolysis and gluconeogenesis; Macrophage-stimulating protein (MSP) signaling network map; Metabolic Epileptic Disorders" "Pyruvate metabolism" "20" "1" "0.977" "0.967" "0.991" "0.919" "1.025" "0.917" "1.015" "0.949" "0.533" "19657.5" "19196.5" "19017.2" "19488.8" "18059.4" "20141.6" "18030.6" "19953.4" "18657.5" "10485.3" "" "" "" "" "" "" "" "" "" "" "11763.9" "9975.7" "10531.3" "9149.5" "8370.9" "10311.0" "8383.9" "8957.9" "10122.5" "10485.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6514754949609892250" "False" "High" "IsMasterProtein" "Q9UQE7" "Structural maintenance of chromosomes protein 3 OS=Homo sapiens OX=9606 GN=SMC3 PE=1 SV=2" "0.000" "False" "117.278" "28" "34" "53" "34" "1217" "141.5" "7.18" "144.38" "34" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "9126" "ENSG00000108055" "SMC3" "A8K156; hsa:9126; O60464; Q5T482; Q9UQE7" "Cell cycle; Retinoblastoma gene in cancer; MECP2 and associated Rett syndrome; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation" "SUMOylation of DNA damage response and repair proteins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "15" "0" "1.021" "0.983" "1.019" "1.053" "1.032" "0.994" "0.962" "0.949" "1.081" "3026.1" "3088.8" "2974.7" "3083.2" "3185.6" "3123.3" "3006.6" "2912.4" "2871.5" "3270.6" "" "" "" "" "" "" "" "" "" "" "1811.0" "1605.1" "1647.3" "1447.5" "1476.6" "1598.9" "1398.0" "1307.5" "1557.9" "3270.6" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4243510454319930112" "False" "High" "IsMasterProtein" "P33992" "DNA replication licensing factor MCM5 OS=Homo sapiens OX=9606 GN=MCM5 PE=1 SV=5" "0.000" "False" "116.867" "37" "26" "71" "26" "734" "82.2" "8.37" "177.58" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4174" "ENSG00000100297" "MCM5" "hsa:4174; O60785; P33992; Q14578; Q9BTJ4; Q9BWL8" "Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "10" "0" "0.996" "0.919" "1.050" "1.036" "1.043" "1.074" "1.089" "1.062" "1.002" "4173.2" "4158.1" "3833.7" "4381.2" "4322.6" "4351.8" "4480.9" "4543.9" "4431.9" "4181.7" "" "" "" "" "" "" "" "" "" "" "2497.4" "2160.8" "2123.0" "2056.9" "2003.6" "2227.8" "2083.5" "2039.9" "2404.5" "4181.7" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3249429330709182822" "False" "High" "IsMasterProtein" "Cont_P68138" "Actin, alpha skeletal muscle OS=Bos taurus OX=9913 GN=ACTA1 PE=1 SV=1" "0.000" "True" "115.903" "32" "14" "453" "1" "377" "42.0" "5.39" "1185.45" "14" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "100065454; 100154254; 100172818; 100395910; 100426612; 100542212; 100566789; 100609865; 100661558; 100716933; 100926492; 100955023; 100987270; 101018268; 101107662; 101316902; 101345310; 101371004; 101561057; 101607063; 101822895; 101878061; 101942538; 101972057; 102017886; 102121165; 102446120; 102836098; 102922102; 102943964; 103051164; 103127961; 103195041; 103624093; 103744113; 103818506; 104131026; 104291844; 104300855; 104488844; 104860683; 104987264; 105499142; 105505494; 105722343; 105823179; 105871143; 106543751; 106843698; 108498591; 108537854; 109248958; 109372851; 109689807; 11459; 281592; 29437; 58" "ENSABRG00000018240; ENSACAG00000001104; ENSACCG00020004955; ENSACDG00005004064; ENSACOG00000015573; ENSAMEG00000005186; ENSANAG00000033052; ENSANIG00000015411; ENSAOWG00000018027; ENSAPLG00000004146; ENSAPLG00020002125; ENSBGRG00000020862; ENSBIXG00000012362; ENSBIXG00005025901; ENSBMSG00010014761; ENSBTAG00000046332; ENSCABG00000013181; ENSCAFG00000008253; ENSCAFG00020027254; ENSCAFG00030012637; ENSCANG00000033017; ENSCCAG00000035682; ENSCCNG00000030664; ENSCGRG00001016859; ENSCJAG00000011114; ENSCLAG00000003307; ENSCMMG00000014710; ENSCMUG00000000473; ENSCPBG00000006129; ENSCPGG00000000824; ENSCPIG00010005220; ENSCPOG00000032187; ENSCPVG00000014620; ENSCSRG00000013784; ENSCUSG00005000547; ENSCWAG00000013028; ENSDLEG00000008382; ENSDNVG00000014331; ENSEASG00005031337; ENSEGOG00005009171; ENSFCAG00000030433; ENSFDAG00000018383; ENSFTIG00000004572; ENSG00000143632; ENSGAGG00000007922; ENSGEVG00005016044; ENSJHYG00000007552; ENSJJAG00000019369; ENSLAFG00000006306; ENSLCNG00005015654; ENSLLTG00000003642; ENSMCSG00000014926; ENSMFAG00000002280; ENSMGAG00000012010; ENSMICG00000007460; ENSMMNG00015014953; ENSMMSG00000010015; ENSMMUG00000022086; ENSMNEG00000003684; ENSMSIG00000009031; ENSMUNG00000016766; ENSMUSG00000031972; ENSNGAG00000008844; ENSNVIG00000023437; ENSOANG00000012845; ENSOARG00000003044; ENSOGAG00000016005; ENSOSUG00000015814; ENSPANG00000005524; ENSPCEG00000011384; ENSPCLG00000000773; ENSPCOG00000022008; ENSPCTG00005016061; ENSPEMG00000019882; ENSPLOG00000020512; ENSPMRG00000005431; ENSPPAG00000033916; ENSPPYG00000000127; ENSPSIG00000002854; ENSPSNG00000011648; ENSPSTG00000017705; ENSPTRG00000002086; ENSRBIG00000037124; ENSRFEG00010013727; ENSRNOG00000017786; ENSRNOG00055021900; ENSRNOG00060017592; ENSRNOG00065018197; ENSSCAG00000003577; ENSSHAG00000014035; ENSSHBG00005006730; ENSSMRG00000022024; ENSSOCG00000011564; ENSSSCG00000010190; ENSSSCG00015047339; ENSSSCG00040044916; ENSSSCG00055024685; ENSSSCG00065076746; ENSSSUG00005003524; ENSSTOG00000024222; ENSSVLG00005008349; ENSTGEG00000010273; ENSTGUG00000010041; ENSUAMG00000015031; ENSUPAG00010000311; ENSVKKG00000017431; ENSVURG00010000907; ENSVURG00010001203" "Acta1; ACTA1; LOC101345310; LOC101878061; LOC103127961; LOC103661861; LOC111160482; LOC112807841" "A0A090BWQ4; A0A091DQ28; A0A091EBT4; A0A091GSF2; A0A091GVU0; A0A091JKH4; A0A093GLM6; A0A096N2Y2; A0A098M1X6; A0A0A0AU99; A0A1S3APV3; A0A1U7QEW4; A0A1W7RJM3; A0A218VBM4; A0A226MSL5; A0A250XZP0; A0A2I0UAK3; A0A2J8M6H1; A0A2J8R810; A0A2K5EBS2; A0A2K5IRF2; A0A2K5S578; A0A2K5TYP0; A0A2K6ANM2; A0A2K6G1G8; A0A2K6LSJ0; A0A2P4SXB1; A0A2R9AZU8; A0A2U3W9D6; A0A2U4BVD6; A0A2Y9E0P7; A0A2Y9HE43; A0A2Y9L6W7; A0A2Y9LGX2; A0A2Y9S7L7; A0A3L7I1B1; A0A3L8S8G5; A0A3M0KHK7; A0A3Q7NT51; A0A452H615; A0A452RJE1; A0A480QNI6; A0A4U1EEU3; A0A4W2GZT5; A0A4X2JWN6; A0A5J5MT96; A0A5N3VLN8; A0A663E501; A0A667HAA9; A0A669PGX8; A0A670I895; A0A671F3Z0; A0A672U2N2; A0A673SW94; A0A6B2F569; A0A6B2F5D9; A0A6D2XHK8; A0A6I9M0F0; A0A6I9XXG7; A0A6J0HG37; A0A6J0T852; A0A6J1U9U4; A0A6J1YDW3; A0A6J2GP26; A0A6J2NA43; A0A6J3CTV5; A0A6J3EY96; A0A6P3ERW2; A0A6P3FJ88; A0A6P3HAS4; A0A6P5LDM6; A0A6P9CIM0; A0A6P9EZA5; A0A7J7EZ09; A0A7J7RJI6; A0A7J7RTV4; A0A7J8B841; A0A7J8BL15; A0A7K4JPE4; A0A7K4PSI7; A0A7K4QY10; A0A7K4RLR4; A0A7K4UDE9; A0A7K4UY42; A0A7K4W696; A0A7K4XA22; A0A7K4Y8W8; A0A7K4ZFF1; A0A7K5BDX3; A0A7K5D428; A0A7K5GNW3; A0A7K5HRK1; A0A7K5IK78; A0A7K5JXK4; A0A7K5KX43; A0A7K5MSI7; A0A7K5NP28; A0A7K5PKH5; A0A7K5QIU3; A0A7K5S142; A0A7K5SPK9; A0A7K5UC76; A0A7K5W8H5; A0A7K5XD37; A0A7K5Y7M0; A0A7K5ZW11; A0A7K6B2F8; A0A7K6BQV7; A0A7K6DCL1; A0A7K6EXZ1; A0A7K6FLR8; A0A7K6GNU4; A0A7K6HR31; A0A7K6J4T9; A0A7K6K4L6; A0A7K6LWQ9; A0A7K6M0L3; A0A7K6P948; A0A7K6RCV4; A0A7K6TEI2; A0A7K6VY88; A0A7K6XPH0; A0A7K6Z9M8; A0A7K6ZR93; A0A7K7AYM3; A0A7K7C659; A0A7K7DZL3; A0A7K7EWS4; A0A7K7G760; A0A7K7IH73; A0A7K7KDI8; A0A7K7KKJ6; A0A7K7MNF7; A0A7K7NEW8; A0A7K7PM04; A0A7K7QH90; A0A7K7RDG5; A0A7K7TAJ1; A0A7K7U609; A0A7K7XKX1; A0A7K8AQB9; A0A7K8BQL5; A0A7K8CRX7; A0A7K8EFR7; A0A7K8FRF9; A0A7K8GQ26; A0A7K8HWN9; A0A7K8ISA9; A0A7K8JPZ4; A0A7K8KS65; A0A7K8M0C5; A0A7K8N2Y9; A0A7K8PDY4; A0A7K8QME0; A0A7K8S6K4; A0A7K8T8U7; A0A7K8U5E0; A0A7K8VJC8; A0A7K8WMV3; A0A7K8Y2D4; A0A7K8YWW6; A0A7K8ZV32; A0A7K9AJ30; A0A7K9BS34; A0A7K9D6V1; A0A7K9EI05; A0A7K9FLR9; A0A7K9I701; A0A7K9IMC9; A0A7K9KC93; A0A7K9MVB8; A0A7K9NB46; A0A7K9PEG9; A0A7K9RST5; A0A7K9TK91; A0A7K9V843; A0A7K9W2K2; A0A7K9WX62; A0A7L0AFU5; A0A7L0BDS5; A0A7L0CIB3; A0A7L0EPL5; A0A7L0FCD1; A0A7L0G7Q5; A0A7L0HND8; A0A7L0II88; A0A7L0KT22; A0A7L0LSN2; A0A7L0NLS0; A0A7L0P7X4; A0A7L0RUG0; A0A7L0SJQ9; A0A7L0UGT7; A0A7L0XTP2; A0A7L0ZS39; A0A7L1B939; A0A7L1BT59; A0A7L1DMI6; A0A7L1DWR3; A0A7L1F253; A0A7L1GIR7; A0A7L1HPS8; A0A7L1IC62; A0A7L1K5Y1; A0A7L1L5V3; A0A7L1M7T5; A0A7L1NKU4; A0A7L1R8Z0; A0A7L1T000; A0A7L1U068; A0A7L1XCH6; A0A7L1YLD6; A0A7L2B7P4; A0A7L2BR48; A0A7L2CKL5; A0A7L2ESG9; A0A7L2FHP9; A0A7L2FY76; A0A7L2HHD4; A0A7L2IA74; A0A7L2JHG8; A0A7L2KMU3; A0A7L2LNS8; A0A7L2P8R5; A0A7L2QEC4; A0A7L2RU84; A0A7L2TB66; A0A7L2UV13; A0A7L2XQZ8; A0A7L2Z1X6; A0A7L2ZLP6; A0A7L3CN30; A0A7L3D9C1; A0A7L3GMY1; A0A7L3GYG9; A0A7L3ID24; A0A7L3IXN1; A0A7L3KUM5; A0A7L3LJJ7; A0A7L3M3X9; A0A7L3PPQ0; A0A7L3QHZ1; A0A7L3RH67; A0A7L3SGI7; A0A7L3U4P6; A0A7L3VNT2; A0A7L3WD55; A0A7L3Y1G6; A0A7L3YVD7; A0A7L3ZS54; A0A7L4AN29; A0A7L4CQM9; A0A7L4D5C7; A0A7L4DZI8; A0A7L4G527; A0A7L4GV55; A0A7L4IYY1; A0A7L4JN17; A0A7L4KJ61; A0A7L4MPA2; A0A7L4NEP2; A0A835NXC8; A0A850U7W3; A0A850V3D3; A0A850XEM6; A0A850Y843; A0A850ZDL2; A0A851BEY3; A0A851CN67; A0A851DTB7; A0A851EK28; A0A851FDE8; A0A851J837; A0A851KA41; A0A851LW39; A0A851NRY4; A0A851QJ25; A0A851RNA5; A0A851U848; A0A851VUC7; A0A851WKT2; A0A851XT74; A0A851YL06; A0A851ZBL2; A0A852BHA9; A0A852CRR6; A0A852D425; A0A852E1V9; A0A852F792; A0A852GJG7; A0A852IBF3; A0A852JDC5; A0A852JR42; A0A852KVX0; A0A852LXY4; A0A852NS61; A0A8B6ZNK4; A0A8B7GBR5; A0A8B7Q300; A0A8B8TZT0; A0A8B9CLG9; A0A8B9DEA1; A0A8B9GFW6; A0A8B9NJE6; A0A8B9QKT1; A0A8B9SHJ3; A0A8B9Y7Y7; A0A8C0DED2; A0A8C0H293; A0A8C0LYE1; A0A8C0N2I3; A0A8C2UWB6; A0A8C3CSU8; A0A8C3FFU4; A0A8C3L8M1; A0A8C3PH13; A0A8C3QCR3; A0A8C3SQW8; A0A8C3TNI9; A0A8C3WY11; A0A8C4PR70; A0A8C4U1I2; A0A8C4YAW6; A0A8C5IXG8; A0A8C5P2E0; A0A8C5RKR8; A0A8C5UFH7; A0A8C6FKL7; A0A8C6GS76; A0A8C6NGV1; A0A8C6QM24; A0A8C7BWL1; A0A8C8BUD5; A0A8C8S3P8; A0A8C8Y8T7; A0A8C9C427; A0A8C9LFS5; A0A8C9MJH4; A0A8D0E9T9; A0A8D0FGF9; A0A8D2B3M6; A0A8D2F0S7; A0A8D2GFE7; A0A8D2LUT0; A0A8J4MUQ6; A0A8J4N2X1; A0A8J4NK31; A0A8J4NVY9; A0A8J4PAG4; A0A8K0BNH4; A0A8K1LSE9; A0A8M1FCK6; A0A8P0NAG9; A0A8S9F5P5; A0A8U0V7M2; A0A9B0WSP0; A0A9F2KUS3; A0A9Q0Y593; A0A9V1E5M8; A0AA35K559; A0AA40L2Y5; A0AA41N2J4; acs:100566789; aful:116488210; aju:106984378; bbis:104987264; brhi:104488844; bta:281592; cang:105505494; cbrc:103624093; ccan:109689807; cfr:102507445; cjc:100395910; cmy:102943964; cpic:101942538; cpoc:100716933; cuca:104060336; cvf:104291844; dle:111163953; dpub:104300855; ecb:100065454; egz:104131026; elk:111160482; F7E1F2; F7FWZ0; F7HNV4; G1K932; G1LEZ5; G1NHJ8; G3SXX7; G3WM41; gga:421534; H0UXP6; H0XEG0; H0ZIF5; H2Q1A9; hai:109372851; hsa:58; I3N266; J3SBR4; K7F4I9; lav:100661558; M3XC93; M7AKZ6; maua:101822895; mcc:100426612; mcf:102121165; mgp:100542212; mmu:11459; mmur:105871143; mni:105499142; ngi:103744113; nss:113413315; nsu:110582311; oas:101107662; oga:100955023; oro:101371004; P02568; P68133; P68134; P68135; P68136; P68137; P68138; P68139; P99020; panu:101018268; pbi:103051164; pcad:102976743; pcoq:105823179; pcw:110217891; pdic:114512380; pgut:117672003; pon:100172818; pps:100987270; pss:102446120; ptr:100609865; pvt:110075363; Q3ZCG3; Q5R9Q5; Q5T8M9; rbb:108537854; rno:29437; scan:103818506; shr:100926492; ssc:100154254; T1E7F6; tmu:101345310; tsr:106543751; U3EUL6; U3I8T6; umr:103661861; V8NV61; W5NYJ1; zca:113923883" "FAS pathway and stress induction of HSP regulation; Hypothetical network for drug addiction; Myometrial relaxation and contraction pathways; Myometrial relaxation and contraction pathways; Fas ligand pathway and stress induction of heat shock proteins; Striated muscle contraction; Myometrial relaxation and contraction pathways; Physico-chemical features and toxicity-associated pathways; Striated muscle contraction pathway; Myometrial relaxation and contraction pathways; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; IL-18 signaling pathway; Burn wound healing; Pleural mesothelioma; Comprehensive IL-17A signaling; Striated muscle contraction" "Striated Muscle Contraction; Striated Muscle Contraction; Striated Muscle Contraction; Striated Muscle Contraction; Striated Muscle Contraction; Striated Muscle Contraction" "22" "0" "0.951" "0.879" "0.894" "0.854" "0.959" "0.874" "0.880" "0.876" "0.576" "513.2" "487.9" "451.0" "458.6" "438.3" "492.0" "448.7" "451.5" "449.8" "295.4" "" "" "" "" "" "" "" "" "" "" "307.1" "253.5" "249.7" "215.3" "203.2" "251.9" "208.6" "202.7" "244.0" "295.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2402053168044673171" "False" "High" "IsMasterProtein" "P06576" "ATP synthase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1B PE=1 SV=3" "0.000" "False" "114.969" "39" "15" "124" "15" "529" "56.5" "5.40" "300.64" "15" "other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00006, Pf02874" "506" "ENSG00000110955" "ATP5F1B" "A8K4X0; hsa:506; P06576; Q14283" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein import; Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "8" "0" "0.944" "0.947" "1.002" "0.961" "1.028" "0.974" "1.042" "0.989" "0.513" "4022.7" "3796.7" "3811.3" "4029.4" "3867.6" "4133.8" "3916.3" "4192.7" "3977.8" "2065.5" "" "" "" "" "" "" "" "" "" "" "2407.3" "1973.0" "2110.6" "1891.7" "1792.7" "2116.2" "1821.0" "1882.3" "2158.1" "2065.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-613397371873318473" "False" "High" "IsMasterProtein" "P34932" "Heat shock 70 kDa protein 4 OS=Homo sapiens OX=9606 GN=HSPA4 PE=1 SV=4" "0.000" "False" "114.475" "32" "23" "53" "22" "840" "94.3" "5.19" "149.96" "23" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00012" "3308" "ENSG00000170606" "HSPA4" "hsa:3308; O95756; P34932; Q2TAL4; Q9BUK9" "Parkin-ubiquitin proteasomal system pathway; HDAC6 interactions in the central nervous system" "Regulation of HSF1-mediated heat shock response" "3" "1" "1.023" "1.066" "1.131" "1.183" "1.120" "1.070" "0.731" "1.063" "4.231" "1772.5" "1812.7" "1889.1" "2004.0" "2096.2" "1984.9" "1895.8" "1295.7" "1883.3" "7499.3" "" "" "" "" "" "" "" "" "" "" "1060.7" "942.0" "1046.1" "940.8" "971.6" "1016.1" "881.5" "581.7" "1021.8" "7499.3" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6576828257658518084" "False" "High" "IsMasterProtein" "Q9BQE3" "Tubulin alpha-1C chain OS=Homo sapiens OX=9606 GN=TUBA1C PE=1 SV=1" "0.000" "False" "114.013" "46" "17" "142" "1" "449" "49.9" "5.10" "382.75" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "84790" "ENSG00000167553" "TUBA1C" "hsa:84790; Q9BQE3" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling; Alzheimer's disease; HDAC6 interactions in the central nervous system" "HCMV Early Events; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Recruitment of NuMA to mitotic centrosomes; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Intraflagellar transport; Recycling pathway of L1; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "37" "0" "1.135" "1.101" "1.194" "1.791" "1.539" "1.361" "1.288" "1.026" "1.051" "24.9" "28.2" "27.4" "29.7" "44.5" "38.3" "33.8" "32.0" "25.5" "26.1" "" "" "" "" "" "" "" "" "" "" "14.9" "14.7" "15.2" "13.9" "20.6" "19.6" "15.7" "14.4" "13.8" "26.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6674387397432112473" "False" "High" "IsMasterProtein" "P68371" "Tubulin beta-4B chain OS=Homo sapiens OX=9606 GN=TUBB4B PE=1 SV=1" "0.000" "False" "113.799" "44" "16" "178" "1" "445" "49.8" "4.89" "402.87" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00091, Pf03953" "10383" "ENSG00000188229" "TUBB4B" "A2BFA2; hsa:10383; P05217; P68371" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Neutrophil degranulation; HCMV Early Events; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Intraflagellar transport; Recycling pathway of L1; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "42" "7" "0.961" "0.878" "0.996" "0.968" "1.004" "1.018" "1.017" "0.943" "0.775" "4783.1" "4598.9" "4200.0" "4763.4" "4628.3" "4802.3" "4867.8" "4863.3" "4509.4" "3707.2" "" "" "" "" "" "" "" "" "" "" "2862.4" "2389.9" "2325.8" "2236.3" "2145.3" "2458.4" "2263.4" "2183.3" "2446.5" "3707.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4769002131436570839" "False" "High" "IsMasterProtein" "Q00610" "Clathrin heavy chain 1 OS=Homo sapiens OX=9606 GN=CLTC PE=1 SV=5" "0.000" "False" "113.400" "19" "29" "61" "29" "1675" "191.5" "5.69" "148.92" "29" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00637, Pf01394, Pf09268, Pf13838" "1213" "ENSG00000141367" "CLTC" "D3DU00; hsa:1213; Q00610; Q6N0A0; Q86TF2" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; Dengue-2 interactions with complement and coagulation cascades; Ebola virus infection in host; Fragile X syndrome; 7q11.23 copy number variation syndrome; Complement and coagulation cascades" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Recycling pathway of L1; MHC class II antigen presentation; RHOV GTPase cycle; Lysosome Vesicle Biogenesis; RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Entry of Influenza Virion into Host Cell via Endocytosis; Formation of annular gap junctions" "25" "0" "1.002" "1.017" "0.992" "1.066" "1.025" "0.905" "0.745" "1.036" "3.806" "1631.9" "1635.2" "1659.7" "1619.5" "1739.9" "1672.1" "1476.8" "1215.6" "1689.9" "6211.7" "" "" "" "" "" "" "" "" "" "" "976.6" "849.8" "919.1" "760.3" "806.5" "856.0" "686.7" "545.7" "916.9" "6211.7" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3418914028943411131" "False" "High" "IsMasterProtein" "P29144" "Tripeptidyl-peptidase 2 OS=Homo sapiens OX=9606 GN=TPP2 PE=1 SV=4" "0.000" "False" "113.252" "25" "31" "87" "31" "1249" "138.3" "6.32" "193.57" "31" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00082, Pf12580, Pf12583, Pf21223, Pf21316" "7174" "ENSG00000134900" "TPP2" "hsa:7174; P29144; Q5VZU8" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.998" "0.957" "1.006" "1.011" "0.975" "1.014" "0.934" "1.003" "0.729" "4591.3" "4584.1" "4395.3" "4619.5" "4641.7" "4478.5" "4657.4" "4290.4" "4603.1" "3348.7" "" "" "" "" "" "" "" "" "" "" "2747.7" "2382.2" "2434.0" "2168.7" "2151.5" "2292.7" "2165.6" "1926.1" "2497.4" "3348.7" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6480137070562712140" "False" "High" "IsMasterProtein" "Cont_Q2KJD0" "Tubulin beta-5 chain OS=Bos taurus OX=9913 GN=TUBB5 PE=2 SV=1" "0.000" "True" "112.702" "44" "16" "190" "2" "444" "49.6" "4.89" "418.78" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "100022562; 100172938; 100303606; 100598146; 100689091; 100718713; 100918219; 100998701; 101034943; 101095657; 101129890; 101318992; 101341456; 101365832; 101593768; 101827904; 101925816; 101965993; 102168953; 102382532; 102506772; 102536943; 102568349; 102831964; 102882060; 102926495; 102963307; 103014346; 103053177; 103080542; 103205965; 103221819; 103261319; 103665004; 104666199; 105074100; 105087494; 105308138; 105498618; 105513957; 105553127; 105600022; 105704569; 105817283; 105855398; 105996956; 106553108; 106825507; 106966617; 107160457; 107498082; 108520633; 108522550; 109249509; 109693530; 203068; 22154; 29214; 396254; 471960; 474830; 574113; 615087; 733686" "ENSACCG00020016918; ENSAMEG00000014418; ENSANAG00000034194; ENSANIG00000003763; ENSAOWG00000004252; ENSBGRG00000008599; ENSBIXG00000008022; ENSBIXG00005015569; ENSBMSG00010013877; ENSBTAG00000006969; ENSCABG00000008181; ENSCAFG00000000443; ENSCAFG00040015599; ENSCAFG00845007927; ENSCANG00000012112; ENSCATG00000014335; ENSCCNG00000028823; ENSCGRG00000007995; ENSCGRG00001023930; ENSCGRG00015028239; ENSCHIG00000025610; ENSCJAG00000048479; ENSCMUG00000016892; ENSCPOG00000035463; ENSCRFG00000007002; ENSCSAG00000008279; ENSCWAG00000006690; ENSEASG00005019680; ENSFCAG00000027444; ENSG00000183311; ENSG00000196230; ENSG00000224156; ENSG00000227739; ENSG00000229684; ENSG00000232421; ENSG00000232575; ENSG00000235067; ENSGAGG00000007027; ENSGGOG00000022655; ENSJJAG00000024145; ENSLCNG00005007041; ENSMFAG00000044340; ENSMICG00000010647; ENSMLEG00000037482; ENSMMMG00000020216; ENSMMNG00015000200; ENSMMNG00015000533; ENSMMNG00015004763; ENSMMSG00000005300; ENSMMUG00000030028; ENSMNEG00000044824; ENSMODG00000023805; ENSMSIG00000015128; ENSMUSG00000001525; ENSNLEG00000005348; ENSOANG00000004061; ENSOARG00000011626; ENSPANG00000015954; ENSPCLG00000013695; ENSPCOG00000022809; ENSPCTG00005009625; ENSPEMG00000025556; ENSPLOG00000016488; ENSPPYG00000016419; ENSPSNG00000012487; ENSPTEG00000030284; ENSPTIG00000006316; ENSPTRG00000017675; ENSRBIG00000034281; ENSRFEG00010000368; ENSRNOG00000061216; ENSRNOG00055006845; ENSRNOG00060003580; ENSRNOG00065029671; ENSRROG00000035442; ENSSBOG00000020987; ENSSDAG00000016166; ENSSHAG00000028751; ENSSHBG00005000940; ENSSOCG00000016453; ENSSSCG00000001379; ENSSSCG00015022877; ENSSSCG00025077784; ENSSSCG00030060370; ENSSSCG00035060189; ENSSSCG00040067819; ENSSSCG00050020383; ENSSSCG00055030461; ENSSSCG00060047808; ENSSSCG00065051381; ENSSSCG00070024618; ENSSSUG00005002289; ENSSTOG00000023492; ENSSVLG00005006345; ENSTGEG00000009306; ENSTGEG00000012139; ENSTGUG00000029087; ENSTSYG00000035292; ENSUAMG00000026276; ENSUMAG00000019678; ENSUPAG00010003937; ENSVURG00010001582; ENSVVUG00000009892; ENSZLMG00000006871" "LOC101341456; LOC106553108; LOC111152509; LOC112622444; LOC114901775; LOC115493080; LOC116436919; TBB7; Tubb; TUBB; Tubb5; TUBB5" "A0A0B8RPP1; A0A0D9R7E7; A0A151MZH9; A0A1S3GEI3; A0A1U7R7I2; A0A1U7SI21; A0A1U7TVN8; A0A1V4L0F2; A0A1W7RC49; A0A218U794; A0A286XDY8; A0A2D4LT52; A0A2D4PSK3; A0A2I3MS98; A0A2J8NXA1; A0A2J8SJF9; A0A2K5EIS8; A0A2K5HGL3; A0A2K5KT86; A0A2K5WBU4; A0A2K5ZFW6; A0A2K6E8N3; A0A2K6G5S3; A0A2K6LAT7; A0A2K6Q336; A0A2K6SLG3; A0A2U3V2D1; A0A2U3WJT7; A0A2Y9EAZ4; A0A2Y9EP82; A0A2Y9HLQ0; A0A2Y9K0M9; A0A2Y9MS78; A0A340WI11; A0A341AY80; A0A384BFD0; A0A384C9R0; A0A387L8L1; A0A3Q7RLV2; A0A3Q7S184; A0A452G3S8; A0A452H2Z1; A0A452SPC5; A0A480TK33; A0A485NK51; A0A4D9DG40; A0A4W2C297; A0A4X2JR93; A0A5E4AVV9; A0A5N3VZ42; A0A5N3WG73; A0A5N4CSN6; A0A663FK44; A0A667GBL5; A0A669QEL9; A0A671DQJ6; A0A672TGM1; A0A673T1T3; A0A674HV74; A0A6B2F8Z8; A0A6B2F9Q6; A0A6I9ILN3; A0A6I9MI92; A0A6I9YS87; A0A6I9ZH14; A0A6J0V952; A0A6J0X5U3; A0A6J1VI28; A0A6J2LA47; A0A6J3H9X1; A0A6P3EF00; A0A6P3RZ49; A0A6P5RBI7; A0A6P6HAZ1; A0A6P7XJA2; A0A6P8P8N4; A0A6P9CC67; A0A6P9FE20; A0A7J7R527; A0A7J7RLA9; A0A7J8GU45; A0A7J8KJ46; A0A7N4PPV2; A0A811YN81; A0A8B7ATI1; A0A8B7EBT6; A0A8B7VFP4; A0A8B9M868; A0A8B9P6J0; A0A8B9X0N8; A0A8C0I1Y2; A0A8C0IPC0; A0A8C0SSP9; A0A8C3VZK5; A0A8C3XAR0; A0A8C4PT60; A0A8C5LKQ9; A0A8C6AUQ3; A0A8C6EXU6; A0A8C6FHM7; A0A8C6MWA3; A0A8C8XQA1; A0A8C9BZ32; A0A8C9I594; A0A8C9J767; A0A8C9USK8; A0A8D0FX24; A0A8D2B3E9; A0A8D2EVN1; A0A8D2GXX0; A0A8D2P6S2; A0A8I3N9K0; A0A8K1G105; A0A8U0NH48; A0A8U7NRV1; A0A9B0X0S4; A0A9F2WGG8; A0A9V1E7C8; A0A9W3GX28; A0A9X9LVU0; A0AA35K0A2; A5D9A3; A6KT85; aju:106966617; amj:102568349; asn:102382532; B1B178; bacu:103014346; bta:615087; caty:105600022; ccan:109693530; cdk:105087494; cfa:474830; cfr:102506772; cge:100689091; chx:102168953; cpoc:100718713; csab:103221819; csyr:103261319; dle:111170669; dord:105996956; F6TYN8; F7F082; fca:101095657; G1LKN6; G1R063; G3HQP8; G3SB76; gga:396254; ggo:101129890; gsh:117346094; hsa:203068; I3ND93; J3S5D8; L5KK71; M3X7Z9; maua:101827904; mcal:110312171; mcc:574113; mdo:100022562; mmu:22154; mmur:105855398; mni:105498618; mpuf:101674529; muo:115466267; nasi:112395403; nle:100598146; nss:113423183; nsu:110586671; oas:100303606; oro:101365832; P05218; P07437; P09244; P69893; P69895; P69897; P99024; pale:102882060; panu:100998701; pbi:103053177; pcad:102979859; pcoq:105817283; pdic:114493854; pgut:117667950; pon:100172938; ptg:102963307; ptr:471960; pvp:105308138; pvt:110090161; Q1XHT6; Q2KJD0; Q3TFB6; Q3THH9; Q3TIL1; Q3UAV4; Q3UF52; Q5R943; Q5SU16; Q5TM69; Q6P9X8; Q767L7; Q7JJU6; Q8WUC1; Q9CY33; ray:107498082; rbb:108520633; rbb:108522550; rno:29214; rro:104666199; S9WJD1; sbq:101034943; shr:100918219; ssc:733686; T1DHR5; tmu:101341456; tsr:106553108; U3FAQ9; U3FM57; umr:103665004; vpc:102536943; vvp:112913571; W5PPT6; zca:113927996" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Opioid receptor pathways; Alzheimer's disease; HDAC6 interactions in the central nervous system" "Neutrophil degranulation; Potential therapeutics for SARS; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2" "57" "0" "0.932" "0.866" "0.869" "0.907" "0.952" "0.843" "0.901" "0.906" "0.967" "2135.2" "1990.9" "1848.9" "1856.0" "1935.8" "2033.6" "1798.9" "1924.3" "1935.0" "2065.1" "" "" "" "" "" "" "" "" "" "" "1277.8" "1034.6" "1023.9" "871.4" "897.3" "1041.0" "836.5" "863.9" "1049.8" "2065.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7379954125319751521" "False" "High" "IsMasterProtein" "P48643" "T-complex protein 1 subunit epsilon OS=Homo sapiens OX=9606 GN=CCT5 PE=1 SV=1" "0.000" "False" "110.781" "38" "20" "117" "19" "541" "59.6" "5.66" "305.94" "20" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00118" "22948" "ENSG00000150753" "CCT5" "A8JZY8; A8K2X8; B4DYD8; hsa:22948; P48643" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "7" "0" "0.982" "0.941" "0.974" "0.941" "1.010" "0.930" "0.993" "0.979" "0.670" "6183.9" "6072.5" "5821.2" "6023.7" "5818.3" "6242.7" "5748.7" "6137.6" "6055.3" "4146.2" "" "" "" "" "" "" "" "" "" "" "3700.7" "3155.6" "3223.7" "2828.0" "2696.9" "3195.8" "2673.0" "2755.4" "3285.2" "4146.2" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6180366262275080504" "False" "High" "IsMasterProtein" "P00505" "Aspartate aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=GOT2 PE=1 SV=3" "0.000" "False" "109.031" "40" "19" "150" "19" "430" "47.5" "9.01" "397.58" "19" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;mitochondrion" "other molecular function" "Pf00155" "2806" "ENSG00000125166" "GOT2" "B4DJA6; E7ERW2; hsa:2806; P00505; Q53FL3; Q9BWA3" "Alanine and aspartate metabolism; Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glyoxylate metabolism and glycine degradation; Gluconeogenesis; Aspartate and asparagine metabolism; Glutamate and glutamine metabolism; Degradation of cysteine and homocysteine" "11" "0" "0.959" "0.929" "0.882" "0.915" "0.798" "1.074" "0.873" "1.035" "0.510" "12356.1" "11847.6" "11483.6" "10896.9" "11310.9" "9861.0" "13267.0" "10792.7" "12784.0" "6302.3" "" "" "" "" "" "" "" "" "" "" "7394.5" "6156.8" "6359.4" "5115.8" "5242.8" "5048.1" "6168.9" "4845.3" "6935.9" "6302.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7845595134204648988" "False" "High" "IsMasterProtein" "Q8NE71" "ATP-binding cassette sub-family F member 1 OS=Homo sapiens OX=9606 GN=ABCF1 PE=1 SV=2" "0.000" "False" "108.651" "27" "18" "48" "18" "845" "95.9" "6.80" "131.21" "18" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00005" "23" "ENSG00000204574; ENSG00000206490; ENSG00000225989; ENSG00000231129; ENSG00000232169; ENSG00000236149; ENSG00000236342" "ABCF1" "A2BF75; hsa:23; O14897; Q69YP6; Q8NE71" "IL-18 signaling pathway" "ABC-family proteins mediated transport" "2" "0" "1.064" "0.939" "1.102" "1.047" "1.067" "1.096" "1.059" "1.051" "1.041" "1835.6" "1952.2" "1724.1" "2023.5" "1921.9" "1959.5" "2011.4" "1944.2" "1928.4" "1911.2" "" "" "" "" "" "" "" "" "" "" "1098.5" "1014.5" "954.8" "950.0" "890.9" "1003.1" "935.3" "872.8" "1046.2" "1911.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8891268094734712955" "False" "High" "IsMasterProtein" "Q13428" "Treacle protein OS=Homo sapiens OX=9606 GN=TCOF1 PE=1 SV=3" "0.000" "False" "108.276" "19" "27" "45" "27" "1488" "152.0" "9.04" "123.97" "27" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf03546" "6949" "ENSG00000070814" "TCOF1" "A0JLU0; B4E111; hsa:6949; Q13428; Q6SC72; Q7Z5W9; Q96A52; Q99408; Q99860" "" "" "0" "0" "1.030" "1.005" "1.047" "1.060" "0.972" "1.009" "0.963" "0.914" "0.911" "2138.5" "2202.2" "2148.2" "2239.4" "2266.7" "2079.5" "2157.8" "2058.5" "1955.4" "1947.5" "" "" "" "" "" "" "" "" "" "" "1279.8" "1144.4" "1189.6" "1051.3" "1050.7" "1064.5" "1003.3" "924.1" "1060.9" "1947.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6496925005546959600" "False" "High" "IsMasterProtein" "Q13509" "Tubulin beta-3 chain OS=Homo sapiens OX=9606 GN=TUBB3 PE=1 SV=2" "0.000" "False" "108.233" "47" "17" "163" "4" "450" "50.4" "4.93" "372.20" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction" "cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "10381" "ENSG00000258947" "TUBB3" "A8K854; hsa:10381; Q13509; Q9BTZ0; Q9BW10" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Exercise-induced circadian regulation; Alzheimer's disease; Cell lineage map for neuronal differentiation; HDAC6 interactions in the central nervous system" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Hedgehog 'off' state; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Post-chaperonin tubulin folding pathway; The role of GTSE1 in G2/M progression after G2 checkpoint; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Intraflagellar transport; Recycling pathway of L1; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Prefoldin mediated transfer of substrate to CCT/TriC" "38" "12" "0.951" "0.865" "0.998" "0.947" "1.014" "0.977" "0.989" "0.938" "0.750" "5504.2" "5234.4" "4760.6" "5491.1" "5214.5" "5578.7" "5377.6" "5445.9" "5165.5" "4126.3" "" "" "" "" "" "" "" "" "" "" "3293.9" "2720.1" "2636.3" "2577.9" "2417.0" "2855.8" "2500.5" "2444.9" "2802.5" "4126.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4595887854081889880" "False" "High" "IsMasterProtein" "Q99460" "26S proteasome non-ATPase regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PSMD1 PE=1 SV=2" "0.000" "False" "107.821" "25" "21" "55" "21" "953" "105.8" "5.39" "151.30" "21" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf01851, Pf13646, Pf18004, Pf21505" "5707" "ENSG00000173692" "PSMD1" "B8ZZH9; hsa:5707; Q24JU0; Q53TI2; Q6GMU5; Q6P2P4; Q6PJM7; Q6PKG9; Q86VU1; Q8IV79; Q99460" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Neutrophil degranulation" "64" "0" "1.005" "0.938" "1.035" "0.956" "1.012" "0.991" "1.049" "0.982" "0.711" "4250.8" "4273.6" "3987.2" "4401.0" "4061.9" "4300.2" "4211.4" "4459.7" "4176.1" "3022.8" "" "" "" "" "" "" "" "" "" "" "2543.9" "2220.8" "2208.0" "2066.2" "1882.8" "2201.4" "1958.2" "2002.1" "2265.7" "3022.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4471349255838518587" "False" "High" "IsMasterProtein" "P23526" "Adenosylhomocysteinase OS=Homo sapiens OX=9606 GN=AHCY PE=1 SV=4" "0.000" "False" "106.629" "44" "21" "113" "19" "432" "47.7" "6.34" "297.89" "21" "other metabolic processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00670, Pf05221" "191" "ENSG00000101444" "AHCY" "A8K307; B3KUN3; E1P5P2; F5H737; hsa:191; P23526; Q96A36" "Folate metabolism; Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; Ethanol effects on histone modifications; Spina bifida" "Methylation; Sulfur amino acid metabolism; Metabolism of ingested SeMet, Sec, MeSec into H2Se; Defective AHCY causes HMAHCHD" "11" "2" "0.975" "0.924" "0.994" "0.952" "1.004" "0.929" "0.991" "0.961" "0.633" "8600.0" "8381.9" "7948.9" "8549.5" "8189.9" "8638.3" "7993.0" "8525.3" "8267.2" "5445.7" "" "" "" "" "" "" "" "" "" "" "5146.6" "4355.8" "4401.9" "4013.8" "3796.2" "4422.1" "3716.6" "3827.4" "4485.3" "5445.7" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-66753491464337277" "False" "High" "IsMasterProtein" "Q13813" "Spectrin alpha chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTAN1 PE=1 SV=3" "0.000" "False" "106.494" "14" "33" "39" "33" "2472" "284.4" "5.35" "97.31" "33" "cell organization and biogenesis" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf00435, Pf08726, Pf13499" "6709" "ENSG00000197694" "SPTAN1" "hsa:6709; Q13186; Q13813; Q15324; Q16606; Q59EF1; Q5VXV5; Q5VXV6; Q7Z6M5; Q9P0V0" "Fas ligand pathway and stress induction of heat shock proteins" "Neutrophil degranulation; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Interaction between L1 and Ankyrins; RHOV GTPase cycle; COPI-mediated anterograde transport; RHOU GTPase cycle; Nephrin family interactions; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Caspase-mediated cleavage of cytoskeletal proteins" "12" "0" "1.104" "1.152" "1.078" "1.118" "1.030" "1.056" "1.060" "1.143" "1.544" "1564.8" "1727.6" "1802.9" "1687.5" "1748.8" "1611.2" "1652.9" "1659.2" "1788.6" "2415.9" "" "" "" "" "" "" "" "" "" "" "936.4" "897.7" "998.4" "792.3" "810.6" "824.8" "768.6" "744.9" "970.4" "2415.9" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7970699774180839953" "False" "High" "IsMasterProtein" "Q9Y230" "RuvB-like 2 OS=Homo sapiens OX=9606 GN=RUVBL2 PE=1 SV=3" "0.000" "False" "105.996" "41" "16" "69" "16" "463" "51.1" "5.64" "200.40" "16" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06068, Pf17856" "10856" "ENSG00000183207" "RUVBL2" "B3KQ59; E7ETE5; hsa:10856; Q6FIB9; Q6PK27; Q9Y230; Q9Y361" "" "HATs acetylate histones; Telomere Extension By Telomerase" "2" "0" "0.955" "0.920" "0.993" "0.934" "1.011" "0.924" "0.966" "0.945" "1.034" "3862.3" "3690.3" "3552.0" "3834.2" "3606.3" "3904.3" "3570.3" "3732.0" "3651.0" "3995.3" "" "" "" "" "" "" "" "" "" "" "2311.3" "1917.7" "1967.0" "1800.0" "1671.6" "1998.7" "1660.1" "1675.4" "1980.8" "3995.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4377208032786879179" "False" "High" "IsMasterProtein" "P51858" "Hepatoma-derived growth factor OS=Homo sapiens OX=9606 GN=HDGF PE=1 SV=1" "0.000" "False" "104.398" "75" "17" "49" "16" "240" "26.8" "4.73" "143.23" "17" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00855" "3068" "ENSG00000143321" "HDGF" "B3KU21; D3DVC9; P51858; Q5SZ07; Q5SZ08; Q5SZ09" "IL-18 signaling pathway" "XBP1(S) activates chaperone genes" "2" "1" "0.987" "1.039" "1.005" "1.065" "1.020" "1.029" "1.064" "0.923" "0.668" "2786.6" "2749.5" "2895.6" "2800.3" "2966.7" "2843.4" "2867.2" "2966.0" "2572.6" "1860.6" "" "" "" "" "" "" "" "" "" "" "1667.6" "1428.8" "1603.5" "1314.7" "1375.1" "1455.6" "1333.2" "1331.6" "1395.8" "1860.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8288854614025876019" "False" "High" "IsMasterProtein" "P62258" "14-3-3 protein epsilon OS=Homo sapiens OX=9606 GN=YWHAE PE=1 SV=1" "0.000" "False" "104.230" "62" "17" "184" "14" "255" "29.2" "4.74" "499.78" "17" "stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00244" "7531" "ENSG00000108953; ENSG00000274474" "YWHAE" "B3KY71; D3DTH5; hsa:7531; P29360; P42655; P62258; Q4VJB6; Q53XZ5; Q63631; Q7M4R4" "Cell cycle; Myometrial relaxation and contraction pathways; VEGFA-VEGFR2 signaling; Calcium regulation in cardiac cells; 17p13.3 (YWHAE) copy number variation; Sudden infant death syndrome (SIDS) susceptibility pathways" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; TP53 Regulates Metabolic Genes; Regulation of HSF1-mediated heat shock response; HSF1 activation; RAB GEFs exchange GTP for GDP on RABs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Signaling by Hippo; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; NADE modulates death signalling; Activation of BAD and translocation to mitochondria" "26" "3" "0.993" "0.996" "0.955" "1.024" "0.998" "0.988" "1.034" "1.019" "0.581" "14425.8" "14325.3" "14364.0" "13774.8" "14776.3" "14394.0" "14246.0" "14913.1" "14699.4" "8379.5" "" "" "" "" "" "" "" "" "" "" "8633.0" "7444.3" "7954.5" "6466.9" "6849.1" "7368.7" "6624.1" "6695.1" "7975.0" "8379.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5903683586191117105" "False" "High" "IsMasterProtein" "Q13200" "26S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PSMD2 PE=1 SV=3" "0.000" "False" "103.634" "27" "24" "88" "24" "908" "100.1" "5.20" "230.96" "24" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01851, Pf17781, Pf18051" "5708" "ENSG00000175166" "PSMD2" "B4DX07; B4DXY1; E7EW34; E9PCS3; hsa:5708; Q12932; Q13200; Q15321; Q53XQ4; Q96I12" "Proteasome degradation; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Antigen processing: Ubiquitination & Proteasome degradation; Downstream TCR signaling; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "0.993" "0.968" "1.001" "0.998" "1.088" "0.983" "1.067" "0.998" "0.846" "6464.8" "6419.9" "6257.0" "6470.4" "6454.1" "7032.6" "6356.1" "6895.6" "6451.4" "5469.6" "" "" "" "" "" "" "" "" "" "" "3868.8" "3336.2" "3465.0" "3037.7" "2991.6" "3600.2" "2955.5" "3095.7" "3500.2" "5469.6" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3851021478040607723" "False" "High" "IsMasterProtein" "P31939" "Bifunctional purine biosynthesis protein ATIC OS=Homo sapiens OX=9606 GN=ATIC PE=1 SV=3" "0.000" "False" "103.405" "41" "21" "106" "21" "592" "64.6" "6.71" "266.95" "21" "other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf01808, Pf02142" "471" "ENSG00000138363" "ATIC" "A8K202; E9PBU3; hsa:471; P31939; Q13856; Q53S28" "One-carbon metabolism" "Signaling by ALK fusions and activated point mutants; Purine ribonucleoside monophosphate biosynthesis" "3" "0" "0.961" "0.960" "1.015" "0.936" "0.975" "0.936" "0.952" "0.948" "0.661" "6590.2" "6332.6" "6329.1" "6689.4" "6168.7" "6426.5" "6165.5" "6274.4" "6245.8" "4358.5" "" "" "" "" "" "" "" "" "" "" "3943.9" "3290.8" "3504.9" "3140.5" "2859.3" "3289.9" "2866.8" "2816.8" "3388.6" "4358.5" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6929162783006905550" "False" "High" "IsMasterProtein" "P20042" "Eukaryotic translation initiation factor 2 subunit 2 OS=Homo sapiens OX=9606 GN=EIF2S2 PE=1 SV=2" "0.000" "False" "103.262" "56" "18" "46" "18" "333" "38.4" "5.80" "135.23" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01873" "8894" "ENSG00000125977" "EIF2S2" "hsa:8894; P20042; Q9BVU0; Q9UJE4" "Translation factors; Brain-derived neurotrophic factor (BDNF) signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Primary ovarian insufficiency" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; PKR-mediated signaling; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "16" "0" "0.995" "0.952" "1.020" "0.943" "1.009" "0.953" "1.034" "0.949" "0.641" "2945.5" "2932.2" "2803.1" "3005.8" "2778.2" "2972.2" "2807.1" "3045.4" "2795.4" "1889.2" "" "" "" "" "" "" "" "" "" "" "1762.7" "1523.7" "1552.3" "1411.1" "1287.7" "1521.5" "1305.2" "1367.2" "1516.6" "1889.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3241887692250600056" "False" "High" "IsMasterProtein" "Q15149" "Plectin OS=Homo sapiens OX=9606 GN=PLEC PE=1 SV=3" "0.000" "False" "103.104" "7" "34" "34" "34" "4684" "531.5" "5.96" "81.41" "34" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00681, Pf03501, Pf17902, Pf18373, Pf21019, Pf21020, Pf21097" "5339" "ENSG00000178209" "PLEC" "hsa:5339; Q15148; Q15149; Q16640; Q6S376; Q6S377; Q6S378; Q6S379; Q6S380; Q6S381; Q6S382; Q6S383" "Envelope proteins and their potential roles in EDMD physiopathology" "Assembly of collagen fibrils and other multimeric structures; Caspase-mediated cleavage of cytoskeletal proteins; Type I hemidesmosome assembly" "4" "0" "1.026" "0.957" "1.082" "1.096" "1.041" "1.079" "0.825" "1.066" "3.695" "832.0" "853.4" "796.4" "899.8" "912.2" "866.5" "897.8" "686.3" "886.9" "3074.1" "" "" "" "" "" "" "" "" "" "" "497.9" "443.5" "441.0" "422.4" "422.8" "443.6" "417.5" "308.1" "481.2" "3074.1" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5646758734319931850" "False" "High" "IsMasterProtein" "Q16555" "Dihydropyrimidinase-related protein 2 OS=Homo sapiens OX=9606 GN=DPYSL2 PE=1 SV=1" "0.000" "False" "102.724" "41" "17" "78" "17" "572" "62.3" "6.38" "227.14" "17" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "other molecular function" "Pf01979" "1808" "ENSG00000092964" "DPYSL2" "A8K5H2; B4DR31; D3DSS7; hsa:1808; O00424; Q16555" "Microtubule cytoskeleton regulation; Brain-derived neurotrophic factor (BDNF) signaling pathway" "Recycling pathway of L1; CRMPs in Sema3A signaling" "4" "0" "0.972" "1.001" "1.019" "0.978" "1.021" "0.922" "1.054" "1.054" "0.643" "3244.8" "3154.7" "3248.1" "3306.4" "3174.3" "3311.9" "2991.7" "3420.2" "3421.3" "2087.6" "" "" "" "" "" "" "" "" "" "" "1941.8" "1639.4" "1798.7" "1552.3" "1471.4" "1695.4" "1391.1" "1535.5" "1856.2" "2087.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3405603430523799899" "False" "High" "IsMasterProtein" "P52888" "Thimet oligopeptidase OS=Homo sapiens OX=9606 GN=THOP1 PE=1 SV=2" "0.000" "False" "102.043" "36" "26" "65" "26" "689" "78.8" "6.05" "176.78" "26" "protein metabolism;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01432" "7064" "ENSG00000172009" "THOP1" "B3KSE2; hsa:7064; P52888; Q9UCB3" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.983" "0.977" "1.008" "0.989" "0.961" "0.947" "1.046" "0.964" "0.646" "4196.6" "4126.1" "4099.9" "4230.3" "4151.8" "4032.1" "3974.1" "4390.8" "4047.4" "2710.0" "" "" "" "" "" "" "" "" "" "" "2511.4" "2144.2" "2270.5" "1986.0" "1924.4" "2064.1" "1847.9" "1971.2" "2195.9" "2710.0" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8957423501143175457" "False" "High" "IsMasterProtein" "Cont_P81948" "Tubulin alpha-4A chain OS=Bos taurus OX=9913 GN=TUBA4A PE=1 SV=2" "0.000" "True" "102.021" "45" "17" "109" "3" "448" "49.9" "5.06" "311.53" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "100151951; 100302357; 100354352; 100400294; 100449357; 100734500; 100767686; 100995882; 101006121; 101095277; 101148853; 101379814; 101569770; 101606396; 101677236; 101838478; 101926805; 101969889; 102012828; 102177846; 102532857; 102746509; 102841369; 102928867; 102962068; 103007004; 103072784; 103110543; 103217904; 103261248; 103662744; 103727749; 104660054; 105064041; 105481257; 105504700; 105528059; 105587029; 105808789; 105857673; 105996598; 107138719; 107516732; 109265033; 109571050; 22145; 316531; 470654; 478918; 702583; 7277; 777775" "ENSANAG00000028048; ENSBIXG00005021445; ENSBMSG00010001061; ENSBTAG00000030974; ENSCAFG00000015209; ENSCAFG00020027000; ENSCAFG00030011006; ENSCAFG00845029842; ENSCANG00000024607; ENSCATG00000033332; ENSCGRG00001024425; ENSCHIG00000002435; ENSCJAG00000070762; ENSCLAG00000011603; ENSCPOG00000037151; ENSCSAG00000008100; ENSFCAG00000038881; ENSG00000127824; ENSGGOG00000023578; ENSJJAG00000011005; ENSLCNG00005009789; ENSMFAG00000007541; ENSMICG00000035827; ENSMLEG00000029671; ENSMMMG00000020450; ENSMMSG00000019327; ENSMMUG00000019628; ENSMNEG00000039170; ENSMSIG00000018170; ENSMUSG00000026202; ENSNGAG00000020443; ENSNLEG00000027445; ENSOARG00000020020; ENSOCUG00000026994; ENSPANG00000041659; ENSPCOG00000023925; ENSPEMG00000029240; ENSPLOG00000016209; ENSPPAG00000011142; ENSPPYG00000013203; ENSPSMG00000025346; ENSPSNG00000018656; ENSPTEG00000039375; ENSPTIG00000021758; ENSPTRG00000012949; ENSRNOG00000003597; ENSRNOG00055010434; ENSRNOG00060007884; ENSRNOG00065008885; ENSRROG00000044949; ENSSSCG00000016216; ENSSSCG00025016272; ENSSSCG00035020742; ENSSSCG00040017674; ENSSSCG00050039745; ENSSSCG00070016481; ENSSTOG00000019497; ENSSVLG00005016017; ENSTGEG00000012532; ENSTSYG00000011750; ENSUMAG00000018763; ENSUPAG00010012836; ENSVVUG00000025771" "LOC101334183; LOC102532857; LOC102746509; LOC103662744; LOC106970047; LOC109265033; LOC111143142; LOC111171848; LOC112411846; LOC112838391; LOC112872268; LOC112922524; LOC113920876; LOC114495658; LOC118898366; Tuba4a; TUBA4A" "A0A0D9R6X5; A0A1S2ZI83; A0A1S3GBQ2; A0A1U7Q653; A0A1U7TVH0; A0A286ZNY1; A0A2I2UZ20; A0A2I2YM80; A0A2J8NG28; A0A2J8TUH3; A0A2K5DHU1; A0A2K5HTH7; A0A2K5M1H8; A0A2K5Y6I3; A0A2K6D749; A0A2K6GBF8; A0A2K6RS93; A0A2R8ZC21; A0A2U3W3Z0; A0A2U3YH71; A0A2Y9IV09; A0A2Y9N2F1; A0A340WE79; A0A341CW34; A0A384AKZ1; A0A384C1E6; A0A3Q7QMN7; A0A3Q7SCG6; A0A452DNE3; A0A484GTP9; A0A485MVS4; A0A4W2GGR2; A0A4X1UG19; A0A5N3WUA1; A0A663D8Z2; A0A667GI79; A0A6D2XJT6; A0A6I9I9T5; A0A6I9L693; A0A6J1YN80; A0A6J2LL95; A0A6J3RLQ7; A0A6P3CX09; A0A6P3FIC2; A0A6P5D399; A0A6P6ISG9; A0A6P9F8Q5; A0A7J8JNJ1; A0A811ZBS6; A0A8B7EMV4; A0A8B7KBC2; A0A8B8XXA4; A0A8C0LT90; A0A8C0MZ87; A0A8C2N284; A0A8C2VS48; A0A8C5KB95; A0A8C6E681; A0A8C6EXI3; A0A8C6HJF8; A0A8C6RPC4; A0A8C8XN00; A0A8C9ASB4; A0A8C9CIF4; A0A8C9IX37; A0A8C9KT44; A0A8D2D621; A0A8D2K0Z6; A0A8D2KIE8; A0A8I3Q1H9; A0A8I5NZD6; A0A8U0N0J8; A0A9B0TPY2; A0A9V1FEX0; A0A9W3GNM5; A6JVZ9; A8MUB1; aju:106970047; B3KNQ6; biu:109571050; bta:777775; C5ISA2; caty:105587029; cfr:102522237; chx:102177846; cjc:100400294; cpoc:100734500; csyr:103261248; dle:111171848; dord:105996598; elk:111143142; F6QRE8; F7HZP3; fca:101095277; G1RDQ0; G1TR82; H0V3I8; H2P8P0; H2QJG6; hsa:7277; I3NHW3; K9IKB3; lww:102746509; maua:101838478; mcf:101926805; mmu:22145; mmur:105857673; mpuf:101677236; nasi:112411846; ngi:103727749; oas:100302357; ocu:100354352; oro:101379814; P05215; P68366; P68367; P68368; P81948; panu:101006121; pcoo:112872268; pdic:114495658; pon:100449357; pps:100995882; ptg:102962068; Q17QT1; Q3TY31; Q5E986; Q5XIF6; ray:107516732; rno:316531; rro:104660054; ssc:100151951; umr:103662744; vpc:102532857; vvp:112922524" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease; HDAC6 interactions in the central nervous system" "Platelet degranulation ; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Intraflagellar transport; COPI-mediated anterograde transport; The role of GTSE1 in G2/M progression after G2 checkpoint; Carboxyterminal post-translational modifications of tubulin; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; PKR-mediated signaling; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Recycling pathway of L1; MHC class II antigen presentation; RHO GTPases activate IQGAPs; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Platelet degranulation ; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state; Platelet degranulation ; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation; COPI-mediated anterograde transport; Separation of Sister Chromatids; Anchoring of the basal body to the plasma membrane; PKR-mediated signaling; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; AURKA Activation by TPX2; EML4 and NUDC in mitotic spindle formation; Intraflagellar transport; Carboxyterminal post-translational modifications of tubulin; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recycling pathway of L1; Hedgehog 'off' state; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; The role of GTSE1 in G2/M progression after G2 checkpoint; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Platelet degranulation ; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; The role of GTSE1 in G2/M progression after G2 checkpoint; MHC class II antigen presentation; RHO GTPases Activate Formins; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Intraflagellar transport; Separation of Sister Chromatids; EML4 and NUDC in mitotic spindle formation; Hedgehog 'off' state; Loss of Nlp from mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Kinesins; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; RHO GTPases activate IQGAPs; Carboxyterminal post-translational modifications of tubulin; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; MHC class II antigen presentation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; COPI-independent Golgi-to-ER retrograde traffic; Anchoring of the basal body to the plasma membrane; Platelet degranulation ; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-dependent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Kinesins; PKR-mediated signaling; COPI-mediated anterograde transport; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Hedgehog 'off' state; Intraflagellar transport; Carboxyterminal post-translational modifications of tubulin; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Sealing of the nuclear envelope (NE) by ESCRT-III; Aggrephagy; Recycling pathway of L1; RHO GTPases activate IQGAPs; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane" "160" "0" "0.995" "0.915" "0.960" "1.015" "1.065" "1.015" "1.086" "1.013" "0.853" "742.5" "739.0" "679.5" "712.9" "753.3" "790.6" "753.6" "806.3" "751.9" "633.2" "" "" "" "" "" "" "" "" "" "" "444.3" "384.0" "376.3" "334.7" "349.2" "404.8" "350.4" "362.0" "408.0" "633.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1205545228874989707" "False" "High" "IsMasterProtein" "Q92900" "Regulator of nonsense transcripts 1 OS=Homo sapiens OX=9606 GN=UPF1 PE=1 SV=2" "0.000" "False" "101.430" "22" "24" "49" "24" "1129" "124.3" "6.61" "140.85" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09416, Pf13086, Pf13087, Pf18141" "5976" "ENSG00000005007" "UPF1" "hsa:5976; O00239; O43343; Q86Z25; Q92842; Q92900" "Pathophysiological roles of DUX4 in FSHD1" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "3" "0" "1.028" "0.955" "1.048" "1.050" "1.039" "1.106" "1.065" "1.050" "0.931" "2501.8" "2570.8" "2389.3" "2622.5" "2626.6" "2598.1" "2766.9" "2663.7" "2627.9" "2328.5" "" "" "" "" "" "" "" "" "" "" "1497.2" "1336.0" "1323.1" "1231.2" "1217.5" "1330.0" "1286.5" "1195.9" "1425.8" "2328.5" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8321804652329171157" "False" "High" "IsMasterProtein" "Q9BXJ9" "N-alpha-acetyltransferase 15, NatA auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA15 PE=1 SV=1" "0.000" "False" "100.849" "29" "28" "77" "28" "866" "101.2" "7.42" "195.20" "28" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf12569, Pf13181" "80155" "ENSG00000164134" "NAA15" "D3DNY6; Q52LG9; Q8IWH4; Q8NEV2; Q9BXJ9; Q9H8P6" "" "" "0" "0" "1.012" "0.953" "1.014" "1.008" "1.049" "0.971" "1.037" "0.974" "0.825" "5147.1" "5208.3" "4904.1" "5219.2" "5186.3" "5399.6" "4996.7" "5336.6" "5014.5" "4248.0" "" "" "" "" "" "" "" "" "" "" "3080.3" "2706.6" "2715.8" "2450.3" "2404.0" "2764.2" "2323.4" "2395.8" "2720.6" "4248.0" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2262993958771163174" "False" "High" "IsMasterProtein" "P40926" "Malate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=MDH2 PE=1 SV=3" "0.000" "False" "100.809" "52" "16" "135" "16" "338" "35.5" "8.68" "366.16" "16" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "4191" "ENSG00000146701" "MDH2" "A8K414; B2RE78; B4DE44; E9PDB2; O43682; P40926" "Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; 7q11.23 distal copy number variation; TCA cycle (aka Krebs or citric acid cycle)" "Mitochondrial protein degradation; Gluconeogenesis; Citric acid cycle (TCA cycle)" "10" "0" "0.953" "0.944" "0.965" "0.940" "0.880" "0.970" "0.930" "0.945" "0.507" "9330.6" "8892.0" "8805.6" "9008.3" "8767.9" "8211.9" "9053.1" "8674.3" "8816.9" "4734.1" "" "" "" "" "" "" "" "" "" "" "5583.9" "4620.8" "4876.3" "4229.2" "4064.1" "4203.9" "4209.5" "3894.3" "4783.5" "4734.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4630001761870027344" "False" "High" "IsMasterProtein" "P34897" "Serine hydroxymethyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=SHMT2 PE=1 SV=3" "0.000" "False" "99.992" "47" "19" "163" "18" "504" "56.0" "8.53" "430.19" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00464" "6472" "ENSG00000182199" "SHMT2" "B7Z9F1; E7EQ19; E7EU43; hsa:6472; O00740; P34897; Q8N1A5" "Glycine metabolism; Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Metabolic Epileptic Disorders" "RHOG GTPase cycle; Mitochondrial protein degradation; Metabolism of folate and pterines" "13" "1" "0.934" "0.941" "0.927" "0.940" "0.865" "0.906" "0.886" "0.902" "0.528" "9044.8" "8445.5" "8511.1" "8382.7" "8504.6" "7823.7" "8198.0" "8015.8" "8156.6" "4773.2" "" "" "" "" "" "" "" "" "" "" "5412.8" "4388.8" "4713.3" "3935.5" "3942.0" "4005.2" "3811.9" "3598.6" "4425.3" "4773.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8375301801822560127" "False" "High" "IsMasterProtein" "P36776" "Lon protease homolog, mitochondrial OS=Homo sapiens OX=9606 GN=LONP1 PE=1 SV=2" "0.000" "False" "99.056" "26" "23" "73" "23" "959" "106.4" "6.39" "197.73" "23" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00004, Pf02190, Pf05362" "9361" "ENSG00000196365" "LONP1" "B3KPH8; D6W635; E5KMH8; F5GZ27; hsa:9361; P36776; P36777; Q8N8K8; Q9UQ95" "" "Mitochondrial protein degradation" "1" "0" "0.989" "0.983" "0.971" "1.000" "1.032" "0.960" "0.986" "0.977" "0.694" "4140.9" "4095.0" "4069.1" "4019.5" "4142.6" "4273.7" "3975.3" "4083.6" "4046.6" "2873.7" "" "" "" "" "" "" "" "" "" "" "2478.1" "2128.0" "2253.4" "1887.1" "1920.2" "2187.8" "1848.4" "1833.3" "2195.4" "2873.7" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7738217365816998519" "False" "High" "IsMasterProtein" "P41250" "Glycine--tRNA ligase OS=Homo sapiens OX=9606 GN=GARS1 PE=1 SV=3" "0.000" "False" "97.379" "25" "19" "96" "19" "739" "83.1" "7.03" "246.51" "19" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "non-structural extracellular;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00458, Pf00587, Pf03129" "2617" "ENSG00000106105" "GARS1" "A0A090N8G0; B3KQA2; B4DIA0; hsa:2617; P41250; Q969Y1" "HDAC6 interactions in the central nervous system" "Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "3" "0" "0.996" "1.010" "1.032" "0.969" "0.975" "0.981" "1.045" "0.987" "0.534" "5094.7" "5072.3" "5147.2" "5259.8" "4937.3" "4969.2" "4996.5" "5323.8" "5029.9" "2718.5" "" "" "" "" "" "" "" "" "" "" "3048.9" "2635.9" "2850.4" "2469.3" "2288.5" "2543.8" "2323.3" "2390.1" "2729.0" "2718.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4636491781207187808" "False" "High" "IsMasterProtein" "P14868" "Aspartate--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=DARS1 PE=1 SV=2" "0.000" "False" "97.128" "47" "22" "74" "22" "501" "57.1" "6.55" "191.59" "22" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00152, Pf01336" "1615" "ENSG00000115866" "DARS1" "A8K3J2; D3DP77; hsa:1615; P14868; Q2TNI3; Q32Q69; Q53HV4; Q53YC5; Q68CR9; Q9BW52" "Alanine and aspartate metabolism" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "3" "0" "0.984" "0.945" "1.044" "0.984" "1.046" "0.975" "0.889" "0.977" "1.923" "3459.1" "3403.4" "3268.3" "3611.6" "3404.7" "3616.9" "3371.3" "3076.6" "3380.0" "6652.9" "" "" "" "" "" "" "" "" "" "" "2070.1" "1768.6" "1809.9" "1695.6" "1578.1" "1851.6" "1567.6" "1381.2" "1833.8" "6652.9" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2399497510241032173" "False" "High" "IsMasterProtein" "P25705" "ATP synthase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1A PE=1 SV=1" "0.000" "False" "96.879" "32" "19" "97" "19" "553" "59.7" "9.13" "270.43" "19" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00006, Pf00306, Pf02874" "498" "ENSG00000152234" "ATP5F1A" "A8K092; B4DY56; hsa:498; K7ENP3; P25705; Q53XX6; Q8IXV2; Q96FB4; Q96HW2; Q96IR6; Q9BTV8" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Mitochondrial protein import; Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "7" "0" "0.977" "0.961" "1.000" "0.968" "1.013" "0.956" "1.070" "1.002" "0.392" "6786.6" "6632.2" "6523.9" "6783.6" "6566.9" "6872.3" "6491.3" "7264.8" "6801.2" "2661.9" "" "" "" "" "" "" "" "" "" "" "4061.4" "3446.5" "3612.8" "3184.7" "3043.9" "3518.1" "3018.3" "3261.4" "3689.9" "2661.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3490068427957957642" "False" "High" "IsMasterProtein" "P49588" "Alanine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=AARS1 PE=1 SV=2" "0.000" "False" "96.856" "22" "19" "60" "19" "968" "106.7" "5.53" "156.55" "19" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01411, Pf02272, Pf07973" "16" "ENSG00000090861" "AARS1" "A6NF14; B4DR45; hsa:16; P49588; Q53GV7; Q96FA0" "IL-18 signaling pathway" "Cytosolic tRNA aminoacylation" "2" "0" "0.996" "0.956" "1.039" "0.951" "0.999" "0.975" "1.046" "0.958" "0.785" "3585.1" "3572.5" "3427.0" "3725.2" "3409.9" "3582.8" "3496.2" "3751.3" "3432.9" "2814.6" "" "" "" "" "" "" "" "" "" "" "2145.5" "1856.5" "1897.8" "1748.9" "1580.5" "1834.1" "1625.7" "1684.1" "1862.5" "2814.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4397536938893978881" "False" "High" "IsMasterProtein" "O43491" "Band 4.1-like protein 2 OS=Homo sapiens OX=9606 GN=EPB41L2 PE=1 SV=1" "0.000" "False" "95.942" "25" "22" "39" "21" "1005" "112.5" "5.44" "111.60" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" "2037" "ENSG00000079819" "EPB41L2" "B4DHI8; E9PPD9; hsa:2037; O43491; Q5T4F0; Q68DV2" "Splicing factor NOVA regulated synaptic proteins" "Neurexins and neuroligins" "2" "1" "1.101" "1.078" "1.015" "1.074" "1.098" "1.055" "1.072" "1.105" "0.948" "2047.2" "2253.7" "2207.7" "2078.5" "2199.3" "2247.9" "2160.1" "2193.9" "2262.9" "1941.2" "" "" "" "" "" "" "" "" "" "" "1225.1" "1171.2" "1222.6" "975.8" "1019.4" "1150.7" "1004.4" "984.9" "1227.7" "1941.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5926930809007955556" "False" "High" "IsMasterProtein" "Q92598" "Heat shock protein 105 kDa OS=Homo sapiens OX=9606 GN=HSPH1 PE=1 SV=1" "0.000" "False" "95.499" "24" "19" "47" "17" "858" "96.8" "5.39" "132.90" "19" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00012" "10808" "ENSG00000120694" "HSPH1" "B4DYH1; hsa:10808; O95739; Q5TBM6; Q5TBM7; Q5TBM8; Q92598; Q9UPC4" "" "Regulation of HSF1-mediated heat shock response; Scavenging by Class F Receptors" "2" "1" "1.057" "1.076" "0.979" "1.084" "1.008" "1.070" "0.703" "1.070" "4.953" "1485.8" "1570.5" "1599.2" "1454.4" "1610.6" "1497.0" "1589.8" "1044.5" "1589.2" "7359.8" "" "" "" "" "" "" "" "" "" "" "889.2" "816.1" "885.6" "682.8" "746.5" "766.3" "739.2" "468.9" "862.2" "7359.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-160533791377362281" "False" "High" "IsMasterProtein" "P07195" "L-lactate dehydrogenase B chain OS=Homo sapiens OX=9606 GN=LDHB PE=1 SV=2" "0.000" "False" "94.932" "38" "14" "188" "13" "334" "36.6" "6.05" "537.38" "14" "other metabolic processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "3945" "ENSG00000111716" "LDHB" "hsa:3945; P07195" "Clear cell renal cell carcinoma pathways; CCL18 signaling pathway; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Pyruvate metabolism" "5" "0" "0.987" "0.980" "1.000" "0.939" "1.055" "0.934" "1.052" "0.991" "0.553" "15446.8" "15244.7" "15131.9" "15441.3" "14501.6" "16298.9" "14427.2" "16254.5" "15315.2" "8541.0" "" "" "" "" "" "" "" "" "" "" "9244.1" "7922.1" "8379.7" "7249.3" "6721.7" "8343.8" "6708.3" "7297.3" "8309.1" "8541.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-951770295276680131" "False" "High" "IsMasterProtein" "P09874" "Poly [ADP-ribose] polymerase 1 OS=Homo sapiens OX=9606 GN=PARP1 PE=1 SV=4" "0.000" "False" "94.915" "20" "20" "41" "20" "1014" "113.0" "8.88" "111.61" "20" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf00644, Pf00645, Pf02877, Pf05406, Pf08063, Pf21728" "142" "ENSG00000143799" "PARP1" "B1ANJ4; hsa:142; P09874; Q8IUZ9" "Corticotropin-releasing hormone signaling pathway; Nanoparticle triggered regulated necrosis; Fas ligand pathway and stress induction of heat shock proteins; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Breast cancer pathway; Acute viral myocarditis; Joubert syndrome; Male infertility; Base excision repair; IL-18 signaling pathway; DNA repair pathways, full network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Progeria-associated lipodystrophy; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map" "SUMOylation of DNA damage response and repair proteins; Downregulation of SMAD2/3:SMAD4 transcriptional activity; HDR through MMEJ (alt-NHEJ); Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; vRNA Synthesis; POLB-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER" "25" "0" "1.034" "1.106" "1.027" "1.096" "1.123" "1.134" "0.289" "1.129" "13.290" "720.8" "745.1" "797.2" "740.3" "789.7" "809.6" "817.1" "208.2" "814.1" "9580.3" "" "" "" "" "" "" "" "" "" "" "431.4" "387.2" "441.5" "347.6" "366.1" "414.4" "379.9" "93.5" "441.7" "9580.3" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5217508454541550081" "False" "High" "IsMasterProtein" "P50453" "Serpin B9 OS=Homo sapiens OX=9606 GN=SERPINB9 PE=1 SV=1" "0.000" "False" "94.503" "44" "14" "70" "14" "376" "42.4" "5.86" "200.19" "14" "other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00079" "5272" "ENSG00000170542" "SERPINB9" "B2RBW3; hsa:5272; P50453; Q5TD03" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "" "2" "0" "0.929" "0.936" "0.959" "0.987" "0.983" "0.981" "0.960" "0.977" "0.631" "4623.9" "4293.9" "4326.7" "4434.8" "4562.2" "4543.4" "4536.5" "4440.5" "4519.2" "2915.6" "" "" "" "" "" "" "" "" "" "" "2767.1" "2231.4" "2396.0" "2082.0" "2114.7" "2325.9" "2109.4" "1993.5" "2451.9" "2915.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7001879318500673012" "False" "High" "IsMasterProtein" "P11940" "Polyadenylate-binding protein 1 OS=Homo sapiens OX=9606 GN=PABPC1 PE=1 SV=2" "0.000" "False" "93.956" "33" "19" "107" "15" "636" "70.6" "9.50" "259.33" "19" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00658" "26986" "ENSG00000070756" "PABPC1" "hsa:26986; P11940; Q15097; Q93004" "Translation factors; Endoderm differentiation; VEGFA-VEGFR2 signaling; Acute viral myocarditis" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "13" "4" "1.057" "1.087" "1.086" "1.093" "1.088" "1.052" "1.039" "1.104" "1.263" "4710.1" "4979.9" "5117.9" "5115.1" "5147.5" "5126.4" "4953.2" "4894.0" "5199.6" "5947.7" "" "" "" "" "" "" "" "" "" "" "2818.7" "2587.8" "2834.2" "2401.4" "2385.9" "2624.3" "2303.1" "2197.1" "2821.0" "5947.7" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1039523901046503215" "False" "High" "IsMasterProtein" "P42704" "Leucine-rich PPR motif-containing protein, mitochondrial OS=Homo sapiens OX=9606 GN=LRPPRC PE=1 SV=3" "0.000" "False" "93.904" "21" "28" "50" "28" "1394" "157.8" "6.13" "130.00" "28" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf01535" "10128" "ENSG00000138095" "LRPPRC" "A0PJE3; A8K1V1; hsa:10128; P42704; Q53PC0; Q53QN7; Q6ZUD8; Q7Z7A6; Q96D84" "Ciliary landscape" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial RNA degradation" "5" "0" "1.010" "1.040" "1.146" "1.161" "1.083" "1.154" "0.196" "1.075" "12.693" "953.7" "962.9" "992.1" "1092.5" "1106.8" "1032.8" "1100.2" "186.6" "1025.2" "12104.8" "" "" "" "" "" "" "" "" "" "" "570.7" "500.4" "549.4" "512.9" "513.0" "528.7" "511.6" "83.8" "556.2" "12104.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5771455182534441899" "False" "High" "IsMasterProtein" "P11137" "Microtubule-associated protein 2 OS=Homo sapiens OX=9606 GN=MAP2 PE=1 SV=4" "0.000" "False" "93.681" "17" "26" "37" "26" "1827" "199.4" "4.91" "89.95" "26" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00418, Pf08377" "4133" "ENSG00000078018" "MAP2" "hsa:4133; P11137; Q17S04; Q8IUX2; Q99975; Q99976" "Melatonin metabolism and effects; MAPK cascade; Neurogenesis regulation in the olfactory epithelium; Cell lineage map for neuronal differentiation; Sudden infant death syndrome (SIDS) susceptibility pathways" "" "5" "0" "1.065" "1.019" "1.015" "1.072" "1.017" "0.972" "1.043" "0.970" "0.659" "1862.4" "1984.0" "1897.3" "1890.6" "1997.1" "1893.4" "1809.8" "1942.4" "1807.1" "1227.6" "" "" "" "" "" "" "" "" "" "" "1114.6" "1031.0" "1050.7" "887.6" "925.7" "969.3" "841.5" "872.0" "980.4" "1227.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2749950876556130584" "False" "High" "IsMasterProtein" "P0DMV9" "Heat shock 70 kDa protein 1B OS=Homo sapiens OX=9606 GN=HSPA1B PE=1 SV=1" "0.000" "False" "93.508" "32" "19" "111" "13" "641" "70.0" "5.66" "325.15" "19" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00012" "3303; 3304" "ENSG00000204388; ENSG00000212866; ENSG00000224501; ENSG00000231555; ENSG00000232804" "HSPA1B" "B4E3B6; hsa:3303; hsa:3304; P08107; P0DMV9; P19790; Q5JQI4; Q5SP17; Q9UQL9; Q9UQM0" "Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling; Measles virus infection" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Regulation of HSF1-mediated heat shock response; Neutrophil degranulation; Attenuation phase" "12" "0" "0.975" "0.978" "1.053" "0.968" "0.943" "1.060" "1.036" "1.068" "0.694" "1963.9" "1915.7" "1920.7" "2068.3" "1900.2" "1852.2" "2081.0" "2033.8" "2097.5" "1362.8" "" "" "" "" "" "" "" "" "" "" "1175.3" "995.5" "1063.7" "971.0" "880.8" "948.2" "967.6" "913.1" "1138.0" "1362.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1511702505276588775" "False" "High" "IsMasterProtein" "Q12931" "Heat shock protein 75 kDa, mitochondrial OS=Homo sapiens OX=9606 GN=TRAP1 PE=1 SV=3" "0.000" "False" "93.283" "28" "18" "79" "17" "704" "80.1" "8.21" "210.90" "18" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00183" "10131" "ENSG00000126602" "TRAP1" "B4DR68; D3DUC8; F5H897; hsa:10131; O43642; O75235; Q12931; Q9UHL5" "TNF-alpha signaling pathway; TGF-beta signaling pathway; Clock-controlled autophagy in bone metabolism" "Respiratory electron transport" "4" "0" "0.960" "0.894" "1.037" "1.036" "1.063" "1.063" "1.080" "0.984" "0.783" "3617.2" "3474.2" "3235.4" "3749.3" "3748.7" "3845.7" "3845.1" "3905.3" "3558.4" "2833.9" "" "" "" "" "" "" "" "" "" "" "2164.7" "1805.4" "1791.7" "1760.2" "1737.6" "1968.7" "1787.9" "1753.2" "1930.6" "2833.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1978266596079071295" "False" "High" "IsMasterProtein" "Q01518" "Adenylyl cyclase-associated protein 1 OS=Homo sapiens OX=9606 GN=CAP1 PE=1 SV=5" "0.000" "False" "93.196" "41" "20" "75" "11" "475" "51.9" "8.06" "207.46" "20" "cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf01213, Pf08603" "10487" "ENSG00000131236" "CAP1" "hsa:10487; Q01518; Q53HR7; Q5T0S1; Q5T0S2; Q6I9U6" "Angiopoietin-like protein 8 regulatory pathway; Insulin signaling; Complement system in neuronal development and plasticity; Opioid receptor pathways" "Neutrophil degranulation; Platelet degranulation ; Role of ABL in ROBO-SLIT signaling" "7" "6" "1.094" "1.088" "1.047" "1.032" "1.061" "0.972" "1.033" "1.059" "0.999" "4453.1" "4872.0" "4843.4" "4660.3" "4596.6" "4722.7" "4328.5" "4601.5" "4716.0" "4448.0" "" "" "" "" "" "" "" "" "" "" "2664.9" "2531.8" "2682.1" "2187.9" "2130.6" "2417.7" "2012.7" "2065.8" "2558.6" "4448.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "500586164942944818" "False" "High" "IsMasterProtein" "P67809" "Y-box-binding protein 1 OS=Homo sapiens OX=9606 GN=YBX1 PE=1 SV=3" "0.000" "False" "93.089" "48" "11" "63" "11" "324" "35.9" "9.88" "147.36" "11" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00313" "4904" "ENSG00000065978" "YBX1" "hsa:4904; P16990; P16991; P67809; Q14972; Q15325; Q5FVF0" "Brain-derived neurotrophic factor (BDNF) signaling pathway; MECP2 and associated Rett syndrome; mRNA processing; Sudden infant death syndrome (SIDS) susceptibility pathways" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Interferon gamma signaling; mRNA Splicing - Minor Pathway; Noncanonical activation of NOTCH3" "10" "0" "1.031" "1.110" "1.015" "1.120" "1.036" "1.018" "1.070" "1.029" "0.682" "2253.7" "2323.8" "2502.7" "2287.5" "2524.1" "2336.0" "2294.2" "2411.1" "2319.8" "1536.2" "" "" "" "" "" "" "" "" "" "" "1348.7" "1207.6" "1385.9" "1073.9" "1170.0" "1195.8" "1066.8" "1082.4" "1258.6" "1536.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2158743068394578481" "False" "High" "IsMasterProtein" "P29401" "Transketolase OS=Homo sapiens OX=9606 GN=TKT PE=1 SV=3" "0.000" "False" "92.984" "30" "17" "105" "17" "623" "67.8" "7.66" "298.70" "17" "other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf00456, Pf02779, Pf02780" "7086" "ENSG00000163931" "TKT" "A8K089; B4DE31; E7EPA7; hsa:7086; P29401; Q8TBA3; Q96HH3" "Pentose phosphate metabolism; VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways" "NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate" "7" "0" "0.968" "0.920" "0.932" "0.977" "0.783" "1.041" "0.873" "1.003" "0.531" "9716.9" "9405.3" "8942.8" "9059.9" "9493.1" "7606.9" "10119.2" "8480.5" "9748.1" "5157.5" "" "" "" "" "" "" "" "" "" "" "5815.0" "4887.6" "4952.3" "4253.4" "4400.2" "3894.2" "4705.2" "3807.3" "5288.8" "5157.5" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "623640857413414358" "False" "High" "IsMasterProtein" "P61981" "14-3-3 protein gamma OS=Homo sapiens OX=9606 GN=YWHAG PE=1 SV=2" "0.000" "False" "92.500" "57" "16" "154" "11" "247" "28.3" "4.89" "409.75" "16" "stress response;signal transduction;other biological processes" "cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00244" "7532" "ENSG00000170027" "YWHAG" "hsa:7532; O70457; P35214; P61981; Q6FH52; Q9UDP2; Q9UN99" "Cell cycle; Prolactin signaling pathway; Myometrial relaxation and contraction pathways; Disruption of postsynaptic signaling by CNV; Calcium regulation in cardiac cells; 7q11.23 distal copy number variation; Sudden infant death syndrome (SIDS) susceptibility pathways" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "22" "2" "1.030" "1.051" "1.020" "1.024" "0.992" "1.015" "1.101" "1.053" "0.597" "6150.2" "6333.4" "6461.4" "6275.5" "6297.6" "6100.5" "6243.2" "6769.9" "6478.0" "3668.7" "" "" "" "" "" "" "" "" "" "" "3680.5" "3291.2" "3578.2" "2946.2" "2919.1" "3123.0" "2903.0" "3039.3" "3514.6" "3668.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3927890985374291245" "False" "High" "IsMasterProtein" "P11586" "C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=4" "0.000" "False" "92.326" "24" "22" "67" "22" "935" "101.5" "7.30" "179.47" "22" "other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00763, Pf01268, Pf02882" "4522" "ENSG00000100714" "MTHFD1" "A0A024R652; A0A384N5Y3; B2R5Y2; G3V2B8; hsa:4522; P11586; Q86VC9; Q9BVP5" "Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Male infertility; Spina bifida" "Metabolism of folate and pterines" "6" "0" "1.005" "1.122" "1.118" "1.015" "1.101" "1.003" "0.884" "1.065" "2.384" "2585.9" "2598.9" "2900.7" "2891.8" "2623.6" "2846.4" "2592.4" "2286.6" "2754.6" "6164.9" "" "" "" "" "" "" "" "" "" "" "1547.5" "1350.6" "1606.3" "1357.6" "1216.1" "1457.2" "1205.4" "1026.5" "1494.5" "6164.9" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5506725299494211183" "False" "High" "IsMasterProtein" "P25786" "Proteasome subunit alpha type-1 OS=Homo sapiens OX=9606 GN=PSMA1 PE=1 SV=1" "0.000" "False" "91.143" "52" "15" "85" "15" "263" "29.5" "6.61" "266.56" "15" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00227, Pf10584" "5682" "ENSG00000129084" "PSMA1" "A8K400; hsa:5682; P25786; Q53YE8; Q9BRV9" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "ER-Phagosome pathway; MAPK6/MAPK4 signaling; FCERI mediated NF-kB activation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "1.026" "1.013" "1.123" "1.005" "0.948" "1.093" "1.111" "1.083" "0.689" "4654.7" "4774.5" "4714.1" "5228.5" "4676.0" "4413.1" "5089.0" "5170.2" "5039.4" "3205.0" "" "" "" "" "" "" "" "" "" "" "2785.6" "2481.1" "2610.6" "2454.6" "2167.4" "2259.2" "2366.3" "2321.1" "2734.1" "3205.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7048585715635486560" "False" "High" "IsMasterProtein" "Q13885" "Tubulin beta-2A chain OS=Homo sapiens OX=9606 GN=TUBB2A PE=1 SV=1" "0.000" "False" "90.852" "39" "14" "151" "2" "445" "49.9" "4.89" "332.48" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7280" "ENSG00000137267" "TUBB2A" "hsa:7280; Q13885; Q6FGZ8; Q8IWR2" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Formation of tubulin folding intermediates by CCT/TriC; Prefoldin mediated transfer of substrate to CCT/TriC; PKR-mediated signaling; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Hedgehog 'off' state" "35" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1213395878895108528" "False" "High" "IsMasterProtein" "P26038" "Moesin OS=Homo sapiens OX=9606 GN=MSN PE=1 SV=3" "0.000" "False" "89.092" "37" "25" "66" "18" "577" "67.8" "6.40" "156.84" "25" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "4478" "ENSG00000147065" "MSN" "hsa:4478; P26038" "Glial cell differentiation; AGE/RAGE pathway; Measles virus infection; 16p11.2 proximal deletion syndrome; Regulation of actin cytoskeleton" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Signaling by ALK fusions and activated point mutants" "10" "6" "1.164" "1.272" "1.103" "1.166" "1.078" "1.029" "0.904" "1.149" "2.758" "2968.2" "3455.3" "3776.2" "3274.1" "3461.6" "3198.3" "3054.0" "2682.1" "3409.1" "8187.3" "" "" "" "" "" "" "" "" "" "" "1776.3" "1795.6" "2091.2" "1537.1" "1604.5" "1637.3" "1420.0" "1204.1" "1849.6" "8187.3" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "338610440228744590" "False" "High" "IsMasterProtein" "Q13620" "Cullin-4B OS=Homo sapiens OX=9606 GN=CUL4B PE=1 SV=4" "0.000" "False" "88.156" "25" "24" "39" "17" "913" "103.9" "7.37" "113.22" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8450" "ENSG00000158290" "CUL4B" "B1APK5; B3KVX4; B7Z5K8; hsa:8450; Q13620; Q6PIE4; Q6UP07; Q7Z673; Q9BY37; Q9UEB7; Q9UED7" "Mesodermal commitment pathway; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER" "13" "6" "0.985" "0.972" "0.941" "0.961" "1.076" "0.947" "0.999" "0.978" "0.775" "3040.5" "2994.5" "2956.1" "2862.5" "2923.3" "3272.7" "2880.4" "3037.9" "2972.9" "2357.5" "" "" "" "" "" "" "" "" "" "" "1819.6" "1556.1" "1637.0" "1343.9" "1355.0" "1675.4" "1339.3" "1363.8" "1613.0" "2357.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4155367153969888648" "False" "High" "IsMasterProtein" "Cont_P13645" "Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6" "0.000" "True" "88.111" "30" "16" "37" "15" "584" "58.8" "5.21" "109.14" "16" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038" "3858" "ENSG00000186395" "KRT10" "hsa:3858; P13645; Q14664; Q8N175" "" "Formation of the cornified envelope" "2" "1" "0.425" "5.971" "0.394" "0.310" "0.686" "0.432" "0.471" "0.953" "1.298" "2427.9" "1032.6" "14496.4" "956.2" "753.1" "1666.0" "1049.2" "1142.3" "2313.8" "3151.4" "" "" "" "" "" "" "" "" "" "" "1452.9" "536.6" "8027.8" "448.9" "349.1" "852.9" "487.9" "512.8" "1255.3" "3151.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1011353078992681906" "False" "High" "IsMasterProtein" "P49736" "DNA replication licensing factor MCM2 OS=Homo sapiens OX=9606 GN=MCM2 PE=1 SV=4" "0.000" "False" "87.971" "24" "19" "49" "19" "904" "101.8" "5.52" "123.42" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf12619, Pf14551, Pf17207, Pf17855" "4171" "ENSG00000073111" "MCM2" "hsa:4171; P49736; Q14577; Q15023; Q8N2V1; Q969W7; Q96AE1; Q9BRM7" "Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication; 1p36 copy number variation syndrome" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "11" "0" "1.096" "1.032" "1.177" "1.140" "1.105" "1.250" "0.980" "1.130" "3.501" "1038.7" "1138.5" "1071.6" "1222.8" "1184.1" "1148.0" "1298.6" "1017.4" "1173.5" "3636.5" "" "" "" "" "" "" "" "" "" "" "621.6" "591.6" "593.4" "574.1" "548.8" "587.7" "603.8" "456.8" "636.7" "3636.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2006906941817689569" "False" "High" "IsMasterProtein" "Q9Y520" "Protein PRRC2C OS=Homo sapiens OX=9606 GN=PRRC2C PE=1 SV=4" "0.000" "False" "87.948" "9" "24" "34" "23" "2896" "316.7" "9.13" "80.27" "24" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "" "Pf07001" "23215" "ENSG00000117523" "PRRC2C" "hsa:23215; Q05DM8; Q49A39; Q6PD54; Q9H2N2; Q9HA05; Q9NSM8; Q9NXL3; Q9UF29; Q9UPQ6; Q9Y520" "VEGFA-VEGFR2 signaling" "" "1" "1" "0.997" "0.931" "0.907" "0.923" "0.896" "1.041" "1.001" "0.889" "0.390" "1642.2" "1637.9" "1529.2" "1490.1" "1516.4" "1470.7" "1710.0" "1643.2" "1460.3" "639.7" "" "" "" "" "" "" "" "" "" "" "982.8" "851.2" "846.9" "699.5" "702.9" "752.9" "795.1" "737.7" "792.3" "639.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9142633453092605073" "False" "High" "IsMasterProtein" "Cont_P63103" "14-3-3 protein zeta/delta OS=Bos taurus OX=9913 GN=YWHAZ PE=1 SV=1" "0.000" "True" "87.449" "59" "13" "170" "8" "245" "27.7" "4.79" "426.36" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00244" "100030704; 100056060; 100127113; 100173609; 100411134; 100484483; 100596460; 100672224; 100727182; 100913480; 100977477; 101012101; 101021050; 101151099; 101331119; 101351914; 101384625; 101687663; 101721954; 101968271; 102019696; 102115184; 102175223; 102283808; 102742022; 102765675; 103004481; 103085559; 103121925; 103191924; 103261347; 103732836; 105005492; 105302907; 105476048; 105504209; 105542098; 105586543; 105719669; 105869900; 106847839; 107142838; 107512228; 109277999; 109382800; 109568481; 109697135; 287022; 472830; 475864; 709723; 7534; 780440" "ENSAMEG00000000328; ENSANAG00000027160; ENSBGRG00000009704; ENSBIXG00000019500; ENSBIXG00005001276; ENSBMSG00010017904; ENSBTAG00000000236; ENSCAFG00000000580; ENSCAFG00845028920; ENSCANG00000043345; ENSCATG00000024186; ENSCCAG00000037757; ENSCCNG00000015730; ENSCHIG00000020223; ENSCJAG00000015844; ENSCLAG00000004303; ENSCPOG00000040522; ENSCWAG00000015721; ENSDLEG00000002530; ENSEASG00005002806; ENSECAG00000021882; ENSFCAG00000037073; ENSG00000164924; ENSGGOG00000022133; ENSHGLG00100048437; ENSLAFG00000004944; ENSMFAG00000001740; ENSMICG00000034946; ENSMLEG00000033187; ENSMMMG00000016188; ENSMMNG00015011551; ENSMMSG00000002669; ENSMMUG00000006489; ENSMNEG00000041365; ENSMODG00000006158; ENSMPUG00000015158; ENSNGAG00000006289; ENSNLEG00000030006; ENSPANG00000010317; ENSPANG00000042694; ENSPEMG00000021714; ENSPPAG00000038734; ENSPPYG00000018791; ENSPSMG00000012736; ENSPSNG00000018640; ENSPTEG00000005862; ENSPTIG00000021410; ENSPTRG00000048115; ENSRFEG00010019368; ENSSBOG00000021820; ENSSDAG00000019504; ENSSHAG00000012671; ENSSSCG00000006062; ENSSSCG00015031811; ENSSSCG00025071491; ENSSSCG00035013965; ENSSSCG00045030109; ENSSSCG00050034502; ENSSSCG00055001784; ENSSSCG00060049326; ENSSSCG00070011887; ENSSSUG00005013206; ENSSTOG00000023864; ENSSVLG00005003330; ENSTSYG00000026493; ENSTTRG00000015906; ENSUAMG00000024432; ENSUMAG00000017568; ENSVURG00010007014; ENSVVUG00000013173" "LOC101351914; LOC111146608; Ywhaz; YWHAZ" "A0A096NQ71; A0A097C2Z1; A0A1D5QAJ7; A0A1S3ABR1; A0A1U7TL92; A0A250XWX3; A0A286XIL7; A0A2I2UD77; A0A2I3GBB0; A0A2J8PMJ1; A0A2J8UFH0; A0A2K5DCH7; A0A2K5KE38; A0A2K5L5H7; A0A2K5SHP3; A0A2K5TVK5; A0A2K5YR93; A0A2K6DL02; A0A2K6SRG4; A0A2R9BQD0; A0A2U3W322; A0A2U3YQG6; A0A2U4AHZ7; A0A2Y9GYG0; A0A2Y9JAB1; A0A2Y9PAR8; A0A2Y9QK13; A0A340XXA5; A0A344MNR9; A0A383ZE89; A0A384BYY2; A0A3Q7NYD6; A0A3Q7S418; A0A452SHE3; A0A480PLY3; A0A4W2CSD8; A0A4X1TV95; A0A4X2KB08; A0A518J2H6; A0A5E4AK25; A0A671FTZ7; A0A673UG86; A0A6B0SHT8; A0A6D2XVW1; A0A6J0W154; A0A6J1ZUX6; A0A6J2B9D9; A0A6J2NBP1; A0A6J3FPA9; A0A6P3J5F7; A0A6P3R2S0; A0A6P5CUI6; A0A6P5ISH5; A0A6P6HS74; A0A7J7TL19; A0A7J7VNU9; A0A7J8C4Y7; A0A7J8DUV8; A0A7N4P7P6; A0A7N5KS25; A0A8B6ZD59; A0A8B7G6A9; A0A8B7RAL2; A0A8B8VLP3; A0A8B9X1D7; A0A8C2UZS6; A0A8C3WSB1; A0A8C4KZ72; A0A8C5ZR25; A0A8C6BH51; A0A8C6CXQ8; A0A8C6QKN2; A0A8C8U9V5; A0A8C8ZIR5; A0A8C9E7Q2; A0A8C9GP54; A0A8C9KQT4; A0A8C9Q7D7; A0A8D2CLR5; A0A8I3Q1P7; A0A8J8XBY4; A0A8J8Y9Q2; A0A8P0S6K0; A0A9V1GJ83; A0A9X9LZ30; A8K1N0; aju:106980045; aml:100484483; B7Z465; bacu:103004481; bbis:105005492; biu:109568481; bom:102283808; bta:287022; cang:105504209; caty:105586543; ccan:109697135; cfa:475864; chx:102175223; cjc:100411134; cpoc:100727182; csyr:103261347; D0PNI1; dle:111180376; elk:111146608; F6XEB4; F7BS95; F7EFF6; F7G9D2; F7HBD4; fca:100127113; G3RS45; G3SV87; G5AP01; G7MZV8; G7PCF6; ggo:101151099; hai:109382800; hgl:101721954; hsa:7534; I3N206; K7DDM2; L5M3G8; lav:100672224; lve:103085559; lww:102742022; M3WVC7; M3YUN9; mcc:709723; mcf:102115184; mdo:100030704; mleu:105542098; mmur:105869900; mni:105476048; mpuf:101687663; myd:102765675; ngi:103732836; nle:100596460; nsu:110579154; oro:101384625; P29213; P29312; P63103; P63104; panu:101012101; panu:101021050; pcoo:112859599; pcw:110196285; pdic:114514896; pon:100173609; pps:100977477; ptg:102966103; ptr:472830; pvp:105302907; Q32P43; Q3ZCF9; Q5R651; Q5XJ08; Q6GPI2; Q6IN74; Q6NUR9; Q6P3U9; Q86V33; ray:107512228; sbq:101047958; shr:100913480; tmu:101351914; U3E3R3; umr:103661509; vvp:112916971; zca:113910054" "Calcium regulation in cardiac cell; Cell cycle; Cell cycle; Prolactin signaling pathway; Pathogenic Escherichia coli infection; Myometrial relaxation and contraction pathways; SIDS susceptibility pathways; Pathogenic Escherichia coli infection; Myometrial relaxation and contraction pathways; Hepatitis B infection; GDNF signaling; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways; Calcium regulation in cardiac cells" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; Deactivation of the beta-catenin transactivating complex; TP53 Regulates Metabolic Genes; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria ; Negative regulation of NOTCH4 signaling; TP53 Regulates Metabolic Genes; Interleukin-3, Interleukin-5 and GM-CSF signaling; Activation of BAD and translocation to mitochondria ; Rap1 signalling; RHO GTPases activate PKNs; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Regulation of localization of FOXO transcription factors; Deactivation of the beta-catenin transactivating complex; KSRP (KHSRP) binds and destabilizes mRNA; GP1b-IX-V activation signalling; NOTCH4 Activation and Transmission of Signal to the Nucleus; Interleukin-3, Interleukin-5 and GM-CSF signaling; NOTCH4 Activation and Transmission of Signal to the Nucleus; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Rap1 signalling; KSRP (KHSRP) binds and destabilizes mRNA; GP1b-IX-V activation signalling" "40" "0" "1.044" "0.997" "0.999" "1.097" "1.027" "1.077" "1.088" "1.066" "0.609" "5775.1" "6027.5" "5760.4" "5766.5" "6335.8" "5930.9" "6222.4" "6282.0" "6158.8" "3515.1" "" "" "" "" "" "" "" "" "" "" "3456.1" "3132.3" "3190.0" "2707.2" "2936.7" "3036.2" "2893.3" "2820.2" "3341.4" "3515.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2426861074950700078" "False" "High" "IsMasterProtein" "P22314" "Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens OX=9606 GN=UBA1 PE=1 SV=3" "0.000" "False" "87.283" "20" "18" "52" "18" "1058" "117.8" "5.76" "149.66" "18" "protein metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00899, Pf09358, Pf10585, Pf16190, Pf16191" "7317" "ENSG00000130985" "UBA1" "hsa:7317; P22314; Q5JRR8; Q96E13" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "5" "0" "1.060" "1.191" "1.121" "1.166" "1.022" "1.064" "0.351" "1.028" "11.083" "896.7" "950.2" "1068.0" "1004.8" "1045.7" "916.5" "953.8" "314.3" "922.0" "9937.8" "" "" "" "" "" "" "" "" "" "" "536.6" "493.8" "591.4" "471.7" "484.7" "469.2" "443.5" "141.1" "500.2" "9937.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1146438711958021826" "False" "High" "IsMasterProtein" "Q16851" "UTP--glucose-1-phosphate uridylyltransferase OS=Homo sapiens OX=9606 GN=UGP2 PE=1 SV=5" "0.000" "False" "87.282" "34" "18" "69" "18" "508" "56.9" "8.15" "194.88" "18" "other metabolic processes;developmental processes" "cytosol;other cell component" "other molecular function" "Pf01704" "7360" "ENSG00000169764" "UGP2" "hsa:7360; Q07131; Q0P6K2; Q16851; Q86Y81; Q9BU15" "Exercise-induced circadian regulation; Glycogen synthesis and degradation; Glucuronidation" "Glycogen synthesis; Formation of the active cofactor, UDP-glucuronate" "5" "0" "0.990" "0.973" "1.026" "0.992" "1.030" "0.970" "1.004" "1.017" "0.593" "4040.1" "4001.0" "3931.5" "4144.5" "4006.2" "4163.2" "3918.0" "4054.5" "4107.6" "2397.8" "" "" "" "" "" "" "" "" "" "" "2417.8" "2079.2" "2177.2" "1945.7" "1857.0" "2131.3" "1821.8" "1820.2" "2228.5" "2397.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1343514979661683430" "False" "High" "IsMasterProtein" "P22234" "Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase OS=Homo sapiens OX=9606 GN=PAICS PE=1 SV=3" "0.000" "False" "87.228" "35" "16" "79" "16" "425" "47.0" "7.23" "198.93" "16" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00731, Pf01259" "10606" "ENSG00000128050" "PAICS" "E9PDH9; hsa:10606; P22234; Q68CQ5" "Metabolic reprogramming in colon cancer" "Purine ribonucleoside monophosphate biosynthesis" "2" "0" "0.955" "0.929" "0.967" "0.947" "0.953" "0.956" "0.979" "0.917" "0.533" "7244.5" "6921.2" "6731.1" "7007.6" "6858.3" "6901.8" "6923.5" "7088.8" "6641.0" "3860.7" "" "" "" "" "" "" "" "" "" "" "4335.4" "3596.7" "3727.5" "3289.9" "3179.0" "3533.2" "3219.3" "3182.4" "3603.0" "3860.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4369524592651400068" "False" "High" "IsMasterProtein" "P43490" "Nicotinamide phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAMPT PE=1 SV=1" "0.000" "False" "86.860" "38" "19" "60" "19" "491" "55.5" "7.15" "169.69" "19" "cell-cell signaling;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04095, Pf18127" "10135" "ENSG00000105835" "NAMPT" "A4D0Q9; A4D0R0; hsa:10135; P43490; Q3KQV0; Q8WW95" "Adipogenesis; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Caloric restriction and aging; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence" "NPAS4 regulates expression of target genes; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nicotinamide salvaging" "9" "0" "0.986" "0.938" "0.971" "0.975" "1.007" "0.993" "1.028" "1.019" "0.653" "4593.0" "4527.0" "4306.0" "4460.5" "4477.9" "4623.0" "4559.2" "4720.9" "4682.4" "2999.1" "" "" "" "" "" "" "" "" "" "" "2748.6" "2352.5" "2384.6" "2094.1" "2075.6" "2366.6" "2119.9" "2119.4" "2540.4" "2999.1" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6019619507196981202" "False" "High" "IsMasterProtein" "P61158" "Actin-related protein 3 OS=Homo sapiens OX=9606 GN=ACTR3 PE=1 SV=3" "0.000" "False" "86.824" "34" "14" "70" "14" "418" "47.3" "5.88" "177.13" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "10096" "ENSG00000115091" "ACTR3" "hsa:10096; P32391; P61158; Q53QM2" "Physico-chemical features and toxicity-associated pathways" "FCGR3A-mediated phagocytosis; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "6" "0" "0.916" "0.918" "0.927" "0.912" "0.947" "0.965" "0.938" "0.998" "0.599" "3840.0" "3516.2" "3523.7" "3560.7" "3501.0" "3637.2" "3704.2" "3601.9" "3831.3" "2300.3" "" "" "" "" "" "" "" "" "" "" "2298.0" "1827.3" "1951.4" "1671.7" "1622.8" "1862.0" "1722.4" "1617.0" "2078.6" "2300.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5279545747934132258" "False" "High" "IsMasterProtein" "P04350" "Tubulin beta-4A chain OS=Homo sapiens OX=9606 GN=TUBB4A PE=1 SV=2" "0.000" "False" "86.814" "36" "13" "160" "1" "444" "49.6" "4.88" "359.40" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "10382" "ENSG00000104833" "TUBB4A" "B3KQP4; hsa:10382; P04350; Q969E5" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "41" "0" "1.128" "1.298" "1.163" "0.944" "1.225" "1.007" "1.218" "1.010" "0.852" "52.2" "58.9" "67.8" "60.7" "49.3" "63.9" "52.6" "63.6" "52.7" "44.5" "" "" "" "" "" "" "" "" "" "" "31.2" "30.6" "37.5" "28.5" "22.8" "32.7" "24.4" "28.5" "28.6" "44.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2619416957405686977" "False" "High" "IsMasterProtein" "P49321" "Nuclear autoantigenic sperm protein OS=Homo sapiens OX=9606 GN=NASP PE=1 SV=2" "0.000" "False" "85.914" "24" "16" "32" "16" "788" "85.2" "4.30" "100.04" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10516" "4678" "ENSG00000132780" "NASP" "A8K6H2; B4DQP3; D3DQ07; F5H3J2; hsa:4678; P49321; Q53GW5; Q5T622; Q5T625; Q96A69; Q9BTW2" "" "" "0" "0" "1.120" "1.244" "1.131" "1.199" "1.054" "1.179" "1.060" "1.125" "1.997" "1892.3" "2119.6" "2354.9" "2139.6" "2268.2" "1994.6" "2231.6" "2006.1" "2129.4" "3778.2" "" "" "" "" "" "" "" "" "" "" "1132.4" "1101.5" "1304.1" "1004.5" "1051.4" "1021.1" "1037.6" "900.6" "1155.3" "3778.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1047119725647514999" "False" "High" "IsMasterProtein" "P23588" "Eukaryotic translation initiation factor 4B OS=Homo sapiens OX=9606 GN=EIF4B PE=1 SV=2" "0.000" "False" "85.906" "28" "16" "73" "16" "611" "69.1" "5.73" "175.73" "16" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "nucleic acid binding activity" "Pf00076" "1975" "ENSG00000063046" "EIF4B" "B4DS13; hsa:1975; P23588; Q4G0E3; Q53HQ2; Q6GPH5; Q6IB46; Q8WYK5" "Translation factors; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; Interferon type I signaling pathways" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "16" "0" "1.015" "1.009" "1.049" "1.010" "0.939" "1.017" "1.047" "0.955" "0.447" "4505.6" "4575.4" "4547.1" "4724.4" "4550.3" "4229.7" "4582.4" "4716.8" "4302.8" "2011.8" "" "" "" "" "" "" "" "" "" "" "2696.4" "2377.7" "2518.1" "2218.0" "2109.1" "2165.3" "2130.7" "2117.5" "2334.4" "2011.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-516006275001987462" "False" "High" "IsMasterProtein" "Q14566" "DNA replication licensing factor MCM6 OS=Homo sapiens OX=9606 GN=MCM6 PE=1 SV=1" "0.000" "False" "85.636" "25" "20" "39" "20" "821" "92.8" "5.41" "96.60" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855, Pf18263" "4175" "ENSG00000076003" "MCM6" "B2R6H2; hsa:4175; Q13504; Q14566; Q99859" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "11" "0" "1.088" "1.002" "1.092" "1.185" "1.166" "1.212" "1.014" "1.194" "3.198" "1158.6" "1260.4" "1161.1" "1264.9" "1373.0" "1350.7" "1403.9" "1174.7" "1383.5" "3705.5" "" "" "" "" "" "" "" "" "" "" "693.4" "655.0" "643.0" "593.8" "636.4" "691.5" "652.8" "527.4" "750.6" "3705.5" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4900440247780228765" "False" "High" "IsMasterProtein" "Q13616" "Cullin-1 OS=Homo sapiens OX=9606 GN=CUL1 PE=1 SV=2" "0.000" "False" "85.486" "29" "22" "43" "22" "776" "89.6" "8.00" "105.60" "22" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8454" "ENSG00000055130" "CUL1" "D3DWG3; hsa:8454; O60719; Q08AL6; Q13616; Q8IYW1" "Cell cycle; TNF-alpha signaling pathway; Parkin-ubiquitin proteasomal system pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; Pleural mesothelioma; Notch signaling pathway" "Iron uptake and transport; Nuclear events stimulated by ALK signaling in cancer; Circadian Clock; Regulation of PLK1 Activity at G2/M Transition; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Cyclin D associated events in G1; Regulation of BACH1 activity; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "41" "0" "1.042" "1.011" "1.018" "1.009" "1.057" "0.967" "1.129" "1.105" "0.615" "2765.5" "2882.8" "2796.3" "2816.2" "2789.0" "2922.1" "2673.5" "3122.1" "3055.7" "1701.5" "" "" "" "" "" "" "" "" "" "" "1655.0" "1498.1" "1548.5" "1322.1" "1292.7" "1495.9" "1243.1" "1401.6" "1657.8" "1701.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6837951581036984725" "False" "High" "IsMasterProtein" "P33241" "Lymphocyte-specific protein 1 OS=Homo sapiens OX=9606 GN=LSP1 PE=1 SV=1" "0.000" "False" "85.208" "55" "12" "45" "12" "339" "37.2" "4.74" "146.13" "12" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton" "cytoskeletal activity" "Pf02029" "4046" "ENSG00000130592; ENSG00000288199" "LSP1" "B3KPP1; B3KRR6; E9PBV6; E9PFP3; hsa:4046; P33241; Q16096; Q53H48; Q6FHM3; Q9BUY8" "" "" "0" "0" "0.979" "0.990" "0.921" "0.912" "0.899" "1.063" "1.010" "0.871" "0.473" "3010.6" "2947.2" "2980.4" "2773.3" "2744.9" "2707.7" "3199.5" "3041.9" "2622.3" "1423.6" "" "" "" "" "" "" "" "" "" "" "1801.7" "1531.6" "1650.5" "1302.0" "1272.3" "1386.1" "1487.7" "1365.6" "1422.7" "1423.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4642176776796334220" "False" "High" "IsMasterProtein" "P35580" "Myosin-10 OS=Homo sapiens OX=9606 GN=MYH10 PE=1 SV=3" "0.000" "False" "84.671" "12" "22" "44" "13" "1976" "228.9" "5.54" "124.56" "22" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00063, Pf00612, Pf01576, Pf02736" "4628" "ENSG00000133026" "MYH10" "B2RWP9; D3DTS1; F8VTL3; hsa:4628; P35580; Q12989; Q149N3; Q149N4; Q16087; Q4LE45; Q6PK16; Q9BWG0" "Regulation of actin cytoskeleton" "EPHA-mediated growth cone collapse; RHO GTPases activate PAKs; RHO GTPases activate CIT; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs" "7" "1" "1.049" "1.061" "1.073" "1.145" "1.022" "1.081" "0.842" "1.029" "2.810" "452.9" "475.0" "480.3" "485.9" "518.5" "462.7" "489.4" "381.1" "466.0" "1272.4" "" "" "" "" "" "" "" "" "" "" "271.0" "246.9" "266.0" "228.1" "240.3" "236.9" "227.6" "171.1" "252.8" "1272.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5211801014996619812" "False" "High" "IsMasterProtein" "O43143" "ATP-dependent RNA helicase DHX15 OS=Homo sapiens OX=9606 GN=DHX15 PE=1 SV=2" "0.000" "False" "84.062" "24" "19" "61" "19" "795" "90.9" "7.46" "139.60" "19" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "1665" "ENSG00000109606" "DHX15" "hsa:1665; O43143; Q9NQT7" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.955" "0.873" "1.015" "0.931" "1.008" "0.942" "1.025" "0.911" "0.481" "2312.8" "2207.8" "2018.2" "2348.5" "2152.6" "2330.2" "2178.6" "2371.0" "2107.6" "1111.4" "" "" "" "" "" "" "" "" "" "" "1384.1" "1147.3" "1117.7" "1102.6" "997.8" "1192.9" "1013.0" "1064.5" "1143.5" "1111.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-410325427073227732" "False" "High" "IsMasterProtein" "Cont_P68103" "Elongation factor 1-alpha 1 OS=Bos taurus OX=9913 GN=EEF1A1 PE=1 SV=1" "0.000" "True" "83.821" "31" "14" "215" "7" "462" "50.1" "9.01" "631.95" "14" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "100009189; 100137407; 100173928; 100415334; 100455760; 100583632; 100720380; 100860780; 100894850; 100978974; 101016039; 101102857; 101114018; 101120236; 101143481; 101427577; 101925273; 102283704; 102540473; 102729396; 102952660; 102986013; 103243896; 104657006; 104668174; 104669279; 104675330; 105064770; 105589208; 108529199; 108538073; 109248229; 109261840; 109563706; 1915; 282220; 403506; 493922; 494136; 574059; 716010" "ENSBGRG00000009070; ENSBIXG00000015018; ENSBIXG00005015547; ENSBMUG00000019814; ENSBTAG00000014534; ENSCABG00000013336; ENSCAFG00000002656; ENSCAFG00000054475; ENSCAFG00000056088; ENSCAFG00000057183; ENSCAFG00030004385; ENSCAFG00030013393; ENSCAFG00030013497; ENSCAFG00030026219; ENSCAFG00040018088; ENSCAFG00845012150; ENSCATG00000039727; ENSCCAG00000033087; ENSCHIG00000010087; ENSCJAG00000083200; ENSCPOG00000004067; ENSCSAG00000014041; ENSCWAG00000008166; ENSEASG00005004328; ENSEASG00005023174; ENSFCAG00000030977; ENSG00000156508; ENSGGOG00000025675; ENSLCNG00005010676; ENSMMUG00000004852; ENSNLEG00000035164; ENSOARG00000006149; ENSOARG00000007762; ENSOARG00000011616; ENSOCUG00000008481; ENSPANG00000006932; ENSPCTG00005022294; ENSPLOG00000016117; ENSPPAG00000038736; ENSPPYG00000016777; ENSPTEG00000025546; ENSPTIG00000007871; ENSPTRG00000018347; ENSRBIG00000028957; ENSRROG00000044652; ENSSSCG00005007871; ENSSSCG00015021824; ENSSSCG00035049336; ENSSSCG00060027448; ENSSSCG00065043427; ENSSSCG00070013256; ENSTGEG00000013204" "EEF1A; Eef1a1; EEF1A1; LOC102523342; LOC102540473; LOC105064770; LOC105879067; LOC111096123; LOC111152497; LOC112630422; LOC118356941; RABEFLA2" "A0A096NSJ4; A0A0D9RNJ1; A0A2I3HHP9; A0A2J8PVY3; A0A2J8RYS8; A0A2K5N7Z5; A0A2K5RPQ1; A0A2K6KG30; A0A2K6RQ54; A0A2R9BYN3; A0A2U3XB66; A0A2Y9F799; A0A2Y9HH84; A0A2Y9K0L0; A0A452E2H7; A0A485PKI5; A0A4W2G2H2; A0A4X1U102; A0A5N4BZH2; A0A663DJ63; A0A667H9L1; A0A6I9I937; A0A6J0YU90; A0A6J1ZA85; A0A6J3HMT0; A0A6P5CAS0; A0A6P6HZ37; A0A6P7EC07; A0A6P7EG13; A0A6P9FBB6; A0A811YU57; A0A8B7HCC5; A0A8B8RGI1; A0A8B9X6G1; A0A8C0H2M0; A0A8C0NJT4; A0A8C3W2U9; A0A8C4L5X9; A0A8C8XSK7; A0A8C9HVZ6; A0A8C9JCC1; A0A8D0I6I6; A0A8D2F6F8; A0A8D8FTM6; A0A8H2XW05; A0A8I3VX86; A0A8M1H472; A0A8U0UW05; A0A9L0JZA8; A0A9V1E3R7; A0A9W3GP67; A5PK01; A9X189; aju:106980206; B1MTF5; B7NZC3; biu:109563706; bom:102283704; bta:282220; C3PT41; caty:105589208; cfa:403506; cfr:102523342; chx:100860780; cjc:100415334; cjc:100894850; cpoc:100720380; csab:103243896; dnm:101427577; elk:111152497; F1RQG6; F2Z4P4; F6VFC8; F7AW94; fca:493922; G2HFA2; G3S518; ggo:101143481; H0V2B3; hsa:1915; L8I7U3; lww:102729396; mcc:716010; mcf:101925273; mmur:105879067; mpuf:101672541; nle:100583632; nsu:110583033; oas:101102857; oas:101114018; oas:101120236; ocu:100009189; P04719; P04720; P68103; P68104; P68105; panu:100137407; panu:101016039; pcad:102986013; pcoo:112862036; pon:100173928; pon:100455760; pps:100978974; ptg:102952660; ptr:494136; Q0PY11; Q2KJJ3; Q4R5K0; Q5NVF3; Q5R1X2; Q5R4R8; Q66RN5; Q6IPS9; Q6IQ15; rbb:108529199; rbb:108538073; rro:104657006; rro:104668174; rro:104669279; rro:104675330; ssc:574059; umr:103657393; vpc:102540473; W5PD15; zca:118356820; zca:118356941" "Translation factors; EGFR1 signaling pathway; Fragile X syndrome; 2q37 copy number variation syndrome; EGFR1 signaling pathway" "Neutrophil degranulation; Protein methylation; HSF1 activation; Eukaryotic Translation Elongation; Neutrophil degranulation; Peptide chain elongation; Neutrophil degranulation; Protein methylation; Eukaryotic Translation Elongation; HSF1 activation; Chaperone Mediated Autophagy; Protein methylation; HSF1 activation; SARS-CoV-1 modulates host translation machinery" "20" "6" "0.981" "0.902" "0.994" "1.024" "1.058" "1.015" "1.064" "1.033" "1.055" "19106.2" "18740.9" "17243.2" "18983.5" "19569.6" "20218.6" "19402.0" "20322.1" "19728.2" "20149.4" "" "" "" "" "" "" "" "" "" "" "11434.0" "9739.0" "9548.9" "8912.3" "9070.9" "10350.4" "9021.5" "9123.4" "10703.4" "20149.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7576515921520274560" "False" "High" "IsMasterProtein" "P13667" "Protein disulfide-isomerase A4 OS=Homo sapiens OX=9606 GN=PDIA4 PE=1 SV=2" "0.000" "False" "83.393" "33" "18" "43" "18" "645" "72.9" "5.07" "110.19" "18" "protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;ER/Golgi;other cell component" "other molecular function" "Pf00085, Pf13848" "9601" "ENSG00000155660" "PDIA4" "A8K4K6; hsa:9601; P13667; Q549T6" "" "" "0" "0" "0.942" "1.064" "0.958" "1.021" "0.988" "0.924" "0.734" "1.020" "2.965" "1291.3" "1216.4" "1373.5" "1237.6" "1318.1" "1275.6" "1193.3" "948.4" "1317.8" "3829.0" "" "" "" "" "" "" "" "" "" "" "772.8" "632.1" "760.6" "581.0" "611.0" "653.0" "554.8" "425.8" "714.9" "3829.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6124389197736880790" "False" "High" "IsMasterProtein" "P40925" "Malate dehydrogenase, cytoplasmic OS=Homo sapiens OX=9606 GN=MDH1 PE=1 SV=4" "0.000" "False" "82.566" "45" "16" "122" "16" "334" "36.4" "7.36" "298.75" "16" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00056, Pf02866" "4190" "ENSG00000014641" "MDH1" "B2R5V5; B4DUN2; B7Z3I7; F5H098; hsa:4190; P40925; Q6I9V0" "Sterol regulatory element-binding proteins (SREBP) signaling; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Clear cell renal cell carcinoma pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; TCA cycle in senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; HDAC6 interactions in the central nervous system" "Gluconeogenesis" "10" "0" "1.008" "0.975" "1.012" "0.922" "0.970" "0.939" "0.979" "0.967" "0.554" "8324.1" "8394.6" "8119.0" "8423.8" "7672.8" "8071.5" "7819.6" "8152.0" "8050.8" "4610.0" "" "" "" "" "" "" "" "" "" "" "4981.5" "4362.3" "4496.1" "3954.8" "3556.5" "4132.0" "3636.0" "3659.8" "4367.9" "4610.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5095696648215945885" "False" "High" "IsMasterProtein" "P09972" "Fructose-bisphosphate aldolase C OS=Homo sapiens OX=9606 GN=ALDOC PE=1 SV=2" "0.000" "False" "82.203" "41" "14" "97" "10" "364" "39.4" "6.87" "282.87" "14" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00274" "230" "ENSG00000109107" "ALDOC" "B2R5R3; hsa:230; P09972; Q3SYL3; Q6FH94; Q6P0L5" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Neutrophil degranulation; Glycolysis; Gluconeogenesis" "6" "0" "1.055" "0.934" "1.049" "0.990" "1.021" "1.036" "1.050" "1.029" "0.603" "1390.8" "1467.7" "1298.7" "1459.0" "1377.4" "1419.9" "1440.4" "1460.3" "1431.6" "839.0" "" "" "" "" "" "" "" "" "" "" "832.3" "762.7" "719.2" "685.0" "638.4" "726.9" "669.7" "655.6" "776.7" "839.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2921825731244054349" "False" "High" "IsMasterProtein" "Q99714" "3-hydroxyacyl-CoA dehydrogenase type-2 OS=Homo sapiens OX=9606 GN=HSD17B10 PE=1 SV=3" "0.000" "False" "81.910" "50" "9" "49" "9" "261" "26.9" "7.78" "141.77" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00106" "3028" "ENSG00000072506" "HSD17B10" "hsa:3028; Q5H927; Q6IBS9; Q8TCV9; Q96HD5; Q99714" "Alzheimer's disease and miRNA effects; Valproic acid pathway; Alzheimer's disease" "Branched-chain amino acid catabolism; Mitochondrial protein degradation; tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion" "8" "0" "0.966" "0.927" "0.976" "0.983" "0.978" "0.941" "0.983" "0.960" "0.677" "2572.2" "2484.7" "2385.4" "2510.5" "2529.3" "2516.6" "2420.1" "2527.9" "2469.7" "1740.2" "" "" "" "" "" "" "" "" "" "" "1539.3" "1291.2" "1321.0" "1178.6" "1172.4" "1288.3" "1125.3" "1134.9" "1339.9" "1740.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5836622772794954890" "False" "High" "IsMasterProtein" "P06400" "Retinoblastoma-associated protein OS=Homo sapiens OX=9606 GN=RB1 PE=1 SV=2" "0.000" "False" "81.655" "20" "19" "45" "19" "928" "106.1" "7.94" "126.71" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01857, Pf01858, Pf08934, Pf11934" "5925" "ENSG00000139687" "RB1" "A8K5E3; hsa:5925; P06400; P78499; Q5VW46; Q8IZL4" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Adipogenesis; Spinal cord injury; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor pathway; Bladder cancer; Fas ligand pathway and stress induction of heat shock proteins; Photodynamic therapy-induced AP-1 survival signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Effect of progerin on genes involved in progeria; Ciliary landscape; G1 to S cell cycle control; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Overlap between signal transduction pathways contributing to LMNA laminopathies; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; Sphingolipid metabolism in senescence; Prostaglandin and leukotriene metabolism in senescence ; ID signaling pathway; TROP2 regulatory signaling; Prostaglandin and leukotriene metabolism in senescence ; 8q11.23 (RB1CC1) copy number variation; Omega-6-fatty acids in senescence; DNA damage response" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Aberrant regulation of mitotic exit in cancer due to RB1 defects; RUNX2 regulates osteoblast differentiation; Condensation of Prophase Chromosomes; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; Cyclin A:Cdk2-associated events at S phase entry; Formation of Senescence-Associated Heterochromatin Foci (SAHF); Inhibition of replication initiation of damaged DNA by RB1/E2F1; Defective translocation of RB1 mutants to the nucleus; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome; Nuclear events stimulated by ALK signaling in cancer" "51" "0" "1.000" "0.884" "0.989" "1.046" "1.015" "1.151" "1.156" "1.052" "1.155" "2193.1" "2193.3" "1939.7" "2168.2" "2293.1" "2226.4" "2524.3" "2534.2" "2306.1" "2533.2" "" "" "" "" "" "" "" "" "" "" "1312.4" "1139.8" "1074.2" "1017.9" "1062.9" "1139.7" "1173.8" "1137.7" "1251.2" "2533.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6653265809957974706" "False" "High" "IsMasterProtein" "Q14157" "Ubiquitin-associated protein 2-like OS=Homo sapiens OX=9606 GN=UBAP2L PE=1 SV=2" "0.000" "False" "81.567" "15" "13" "44" "13" "1087" "114.5" "7.11" "127.01" "13" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf12478" "9898" "ENSG00000143569" "UBAP2L" "B4E0U8; hsa:9898; Q14157; Q5VU75; Q5VU76; Q9BTU3; Q9UGL2; Q9UGL3; Q9UGL4; Q9UGL5" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.033" "0.980" "0.949" "1.004" "0.978" "1.060" "1.041" "0.992" "0.596" "2149.5" "2220.5" "2106.2" "2040.9" "2158.7" "2102.6" "2278.3" "2237.5" "2132.8" "1281.6" "" "" "" "" "" "" "" "" "" "" "1286.4" "1153.9" "1166.4" "958.2" "1000.6" "1076.4" "1059.4" "1004.5" "1157.1" "1281.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3779865839115366179" "False" "High" "IsMasterProtein" "P00367" "Glutamate dehydrogenase 1, mitochondrial OS=Homo sapiens OX=9606 GN=GLUD1 PE=1 SV=2" "0.000" "False" "81.265" "32" "17" "62" "17" "558" "61.4" "7.80" "156.81" "17" "other metabolic processes;other biological processes" "mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00208, Pf02812" "2746" "ENSG00000148672" "GLUD1" "B3KV55; B4DGN5; hsa:2746; P00367; Q5TBU3" "VEGFA-VEGFR2 signaling; Amino acid metabolism; Metabolic reprogramming in colon cancer; 22q11.2 copy number variation syndrome; Amino acid metabolism pathway excerpt: histidine catabolism extension; 10q22q23 copy number variation" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation; Glutamate and glutamine metabolism" "9" "0" "0.990" "0.959" "1.002" "0.960" "1.028" "0.906" "1.047" "0.987" "0.548" "4575.6" "4532.0" "4386.6" "4586.4" "4393.6" "4705.6" "4147.4" "4792.1" "4515.6" "2508.0" "" "" "" "" "" "" "" "" "" "" "2738.3" "2355.1" "2429.2" "2153.2" "2036.5" "2408.9" "1928.4" "2151.4" "2449.9" "2508.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2586862151232699530" "False" "High" "IsMasterProtein" "P07237" "Protein disulfide-isomerase OS=Homo sapiens OX=9606 GN=P4HB PE=1 SV=3" "0.000" "False" "80.565" "36" "20" "55" "20" "508" "57.1" "4.87" "155.05" "20" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00085, Pf13848" "5034" "ENSG00000185624" "P4HB" "B2RDQ2; hsa:5034; P07237; P30037; P32079; Q15205; Q6LDE5" "VEGFA-VEGFR2 signaling; Type I collagen synthesis in the context of osteogenesis imperfecta" "Hedgehog ligand biogenesis; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Collagen biosynthesis and modifying enzymes; Detoxification of Reactive Oxygen Species; Insulin processing; Interleukin-12 signaling; Interleukin-23 signaling; Chylomicron assembly; VLDL assembly; LDL remodeling" "13" "0" "0.982" "0.973" "1.001" "0.945" "0.981" "0.957" "1.028" "1.001" "0.633" "4915.4" "4826.4" "4782.4" "4918.2" "4645.9" "4819.7" "4702.2" "5053.0" "4921.1" "3109.4" "" "" "" "" "" "" "" "" "" "" "2941.6" "2508.1" "2648.4" "2309.0" "2153.5" "2467.3" "2186.4" "2268.5" "2669.9" "3109.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5459324364456559330" "False" "High" "IsMasterProtein" "Q04637" "Eukaryotic translation initiation factor 4 gamma 1 OS=Homo sapiens OX=9606 GN=EIF4G1 PE=1 SV=4" "0.000" "False" "80.418" "13" "22" "34" "19" "1599" "175.4" "5.33" "83.22" "22" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02020, Pf02847, Pf02854" "1981" "ENSG00000114867" "EIF4G1" "D3DNT2; D3DNT4; D3DNT5; E9PFM1; G5E9S1; hsa:1981; O43177; O95066; Q04637; Q5HYG0; Q6ZN21; Q8N102" "Translation factors; VEGFA-VEGFR2 signaling; Acute viral myocarditis; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Pleural mesothelioma" "AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Ribosomal scanning and start codon recognition; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "20" "2" "1.052" "1.063" "1.034" "1.054" "1.025" "1.105" "0.687" "1.098" "5.086" "555.3" "584.2" "590.3" "574.2" "585.2" "569.4" "613.4" "381.4" "609.7" "2823.9" "" "" "" "" "" "" "" "" "" "" "332.3" "303.6" "326.9" "269.6" "271.2" "291.5" "285.2" "171.2" "330.8" "2823.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8220013005457955452" "False" "High" "IsMasterProtein" "Q15424" "Scaffold attachment factor B1 OS=Homo sapiens OX=9606 GN=SAFB PE=1 SV=4" "0.000" "False" "80.352" "19" "16" "46" "11" "915" "102.6" "5.47" "123.78" "16" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02037" "6294" "ENSG00000160633" "SAFB" "A0AV56; B7Z5B6; B7ZLP6; F5H0H3; hsa:6294; O60406; Q15424; Q59HH8" "Interleukin-1 (IL-1) structural pathway" "SUMOylation of transcription cofactors" "2" "4" "1.012" "0.972" "0.998" "1.013" "1.036" "0.988" "1.111" "1.076" "0.409" "2038.5" "2062.2" "1980.9" "2035.4" "2065.6" "2111.2" "2014.2" "2265.8" "2193.6" "834.4" "" "" "" "" "" "" "" "" "" "" "1219.9" "1071.7" "1097.0" "955.6" "957.5" "1080.8" "936.5" "1017.2" "1190.1" "834.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3269209104434095274" "False" "High" "IsMasterProtein" "P40227" "T-complex protein 1 subunit zeta OS=Homo sapiens OX=9606 GN=CCT6A PE=1 SV=3" "0.000" "False" "80.297" "31" "17" "107" "17" "531" "58.0" "6.68" "297.89" "17" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "908" "ENSG00000146731" "CCT6A" "A6NCD2; hsa:908; P40227; Q3KP28; Q75LP4; Q96S46" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC" "7" "0" "1.007" "1.008" "1.003" "0.975" "1.036" "0.985" "1.060" "1.003" "0.683" "7715.4" "7770.3" "7779.8" "7736.0" "7524.0" "7993.0" "7601.1" "8182.2" "7740.0" "5269.4" "" "" "" "" "" "" "" "" "" "" "4617.2" "4038.0" "4308.3" "3631.8" "3487.5" "4091.8" "3534.3" "3673.3" "4199.3" "5269.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2887047081584333281" "False" "High" "IsMasterProtein" "P54652" "Heat shock-related 70 kDa protein 2 OS=Homo sapiens OX=9606 GN=HSPA2 PE=1 SV=1" "0.000" "False" "80.117" "20" "15" "162" "1" "639" "70.0" "5.74" "454.12" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00012" "3306" "ENSG00000126803" "HSPA2" "hsa:3306; P54652; Q15508; Q53XM3; Q9UE78" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Measles virus infection; 7q11.23 copy number variation syndrome; Urotensin-II-mediated signaling pathway" "Regulation of HSF1-mediated heat shock response; Meiotic synapsis; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Attenuation phase" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3930283768056647308" "False" "High" "IsMasterProtein" "P31948" "Stress-induced-phosphoprotein 1 OS=Homo sapiens OX=9606 GN=STIP1 PE=1 SV=1" "0.000" "False" "79.168" "37" "22" "79" "22" "543" "62.6" "6.80" "203.10" "22" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00515, Pf13181, Pf17830" "10963" "ENSG00000168439" "STIP1" "B4DM70; F5H0T1; G3XAD8; hsa:10963; P31948; Q3ZCU9; Q5TZU9" "VEGFA-VEGFR2 signaling" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RND1 GTPase cycle" "3" "0" "0.985" "1.008" "0.916" "0.952" "0.964" "0.940" "0.921" "0.981" "0.998" "6985.4" "6883.6" "7041.7" "6399.7" "6649.4" "6731.0" "6565.5" "6431.4" "6854.7" "6973.5" "" "" "" "" "" "" "" "" "" "" "4180.4" "3577.1" "3899.5" "3004.5" "3082.1" "3445.7" "3052.8" "2887.3" "3719.0" "6973.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1618262664170988145" "False" "High" "IsMasterProtein" "P61978" "Heterogeneous nuclear ribonucleoprotein K OS=Homo sapiens OX=9606 GN=HNRNPK PE=1 SV=1" "0.000" "False" "78.905" "33" "15" "70" "15" "463" "50.9" "5.54" "201.52" "15" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf08067" "3190" "ENSG00000165119" "HNRNPK" "hsa:3190; P61978; Q07244; Q15671; Q59F98; Q5T6W4; Q60577; Q6IBN1; Q922Y7; Q96J62" "mRNA processing; lncRNA in canonical Wnt signaling and colorectal cancer" "HCMV Late Events; SUMOylation of RNA binding proteins; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "6" "0" "1.040" "1.028" "1.035" "1.077" "1.058" "1.036" "0.938" "1.088" "2.325" "3636.3" "3781.4" "3736.4" "3763.3" "3915.9" "3848.4" "3768.0" "3412.1" "3956.6" "8453.3" "" "" "" "" "" "" "" "" "" "" "2176.1" "1965.1" "2069.1" "1766.8" "1815.1" "1970.1" "1752.0" "1531.8" "2146.6" "8453.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3549742544018315320" "False" "High" "IsMasterProtein" "O14744" "Protein arginine N-methyltransferase 5 OS=Homo sapiens OX=9606 GN=PRMT5 PE=1 SV=4" "0.000" "False" "78.289" "29" "17" "42" "17" "637" "72.6" "6.29" "118.25" "17" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05185, Pf17285, Pf17286" "10419" "ENSG00000100462" "PRMT5" "A8MTP3; A8MZ91; B4DX49; B4DY30; B5BU10; D3DS33; E2QRE7; hsa:10419; O14744; Q6IBR1; Q9UKH1" "Transcription co-factors SKI and SKIL protein partners; Nitric oxide metabolism in cystic fibrosis" "snRNP Assembly; RMTs methylate histone arginines; Regulation of TP53 Activity through Methylation" "5" "0" "1.031" "0.924" "1.061" "1.005" "1.054" "0.998" "1.072" "1.046" "0.778" "2528.8" "2607.1" "2335.8" "2682.7" "2540.9" "2665.2" "2522.8" "2709.9" "2645.3" "1967.4" "" "" "" "" "" "" "" "" "" "" "1513.3" "1354.8" "1293.5" "1259.5" "1177.7" "1364.4" "1173.0" "1216.6" "1435.2" "1967.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6939588679820243468" "False" "High" "IsMasterProtein" "P23193" "Transcription elongation factor A protein 1 OS=Homo sapiens OX=9606 GN=TCEA1 PE=1 SV=2" "0.000" "False" "78.155" "49" "13" "42" "13" "301" "33.9" "8.38" "109.99" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf07500, Pf08711" "6917" "ENSG00000187735" "TCEA1" "A6NF25; A8K339; hsa:6917; P23193; Q15563; Q6FG87" "" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "15" "0" "1.045" "1.020" "0.997" "1.085" "1.027" "1.051" "0.998" "1.017" "0.892" "1905.1" "1990.8" "1943.9" "1899.2" "2067.8" "1956.7" "2003.1" "1901.2" "1937.7" "1699.0" "" "" "" "" "" "" "" "" "" "" "1140.1" "1034.6" "1076.5" "891.6" "958.5" "1001.7" "931.4" "853.5" "1051.3" "1699.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "479793662138796228" "False" "High" "IsMasterProtein" "P61221" "ATP-binding cassette sub-family E member 1 OS=Homo sapiens OX=9606 GN=ABCE1 PE=1 SV=1" "0.000" "False" "77.651" "19" "12" "43" "12" "599" "67.3" "8.34" "128.48" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;mitochondrion;translational apparatus;other cell component" "enzyme regulator activity;translation activity;other molecular function" "Pf00005, Pf00037, Pf04068" "6059" "ENSG00000164163" "ABCE1" "hsa:6059; O88793; P61221; Q13181; Q13864; Q6NR76; Q96AL0; Q96B10; Q99K66" "" "OAS antiviral response; Interferon alpha/beta signaling" "2" "0" "0.958" "0.930" "0.937" "0.906" "0.990" "0.863" "0.938" "0.915" "0.482" "4962.1" "4751.6" "4616.5" "4650.7" "4494.8" "4913.6" "4284.1" "4652.4" "4542.5" "2390.8" "" "" "" "" "" "" "" "" "" "" "2969.5" "2469.2" "2556.5" "2183.4" "2083.4" "2515.4" "1992.0" "2088.7" "2464.5" "2390.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6965600281876429507" "False" "High" "IsMasterProtein" "P46063" "ATP-dependent DNA helicase Q1 OS=Homo sapiens OX=9606 GN=RECQL PE=1 SV=3" "0.000" "False" "77.401" "30" "17" "47" "17" "649" "73.4" "7.88" "131.27" "17" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf16124" "5965" "ENSG00000004700" "RECQL" "A8K6G2; P46063" "Progeria-associated lipodystrophy" "" "1" "0" "1.066" "1.016" "1.003" "0.940" "1.065" "0.978" "1.090" "1.029" "1.034" "2119.4" "2259.8" "2152.9" "2125.4" "1991.4" "2257.3" "2072.7" "2310.9" "2181.2" "2191.8" "" "" "" "" "" "" "" "" "" "" "1268.4" "1174.3" "1192.2" "997.8" "923.1" "1155.6" "963.7" "1037.4" "1183.4" "2191.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6605193621902288169" "False" "High" "IsMasterProtein" "Cont_P35908" "Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2" "0.000" "True" "77.382" "30" "17" "29" "11" "639" "65.4" "8.00" "82.62" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3849" "ENSG00000172867" "KRT2" "hsa:3849; P35908; Q4VAQ2" "" "Formation of the cornified envelope" "2" "1" "1.067" "3.261" "0.552" "0.715" "1.039" "0.556" "0.833" "1.074" "1.317" "728.8" "777.9" "2376.7" "402.6" "521.2" "757.1" "405.4" "607.1" "782.9" "960.2" "" "" "" "" "" "" "" "" "" "" "436.2" "404.3" "1316.1" "189.0" "241.6" "387.6" "188.5" "272.5" "424.7" "960.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1520164082407222722" "False" "High" "IsMasterProtein" "P07737" "Profilin-1 OS=Homo sapiens OX=9606 GN=PFN1 PE=1 SV=2" "0.000" "False" "77.030" "71" "11" "139" "11" "140" "15.0" "8.27" "326.70" "11" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00235" "5216" "ENSG00000108518" "PFN1" "hsa:5216; P07737; Q53Y44" "Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Burn wound healing; Regulation of actin cytoskeleton; G13 signaling pathway" "RHO GTPases Activate Formins; Platelet degranulation ; PCP/CE pathway; Signaling by ROBO receptors" "9" "0" "0.998" "1.040" "1.077" "0.979" "1.046" "1.060" "1.108" "1.035" "0.789" "6278.7" "6264.6" "6527.0" "6764.9" "6149.8" "6565.8" "6654.1" "6956.1" "6500.9" "4952.7" "" "" "" "" "" "" "" "" "" "" "3757.5" "3255.5" "3614.5" "3176.0" "2850.6" "3361.2" "3094.0" "3122.9" "3527.0" "4952.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8282495750123490209" "False" "High" "IsMasterProtein" "Q96AE4" "Far upstream element-binding protein 1 OS=Homo sapiens OX=9606 GN=FUBP1 PE=1 SV=3" "0.000" "False" "77.022" "25" "17" "66" "12" "644" "67.5" "7.61" "173.36" "17" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00013, Pf09005" "8880" "ENSG00000162613" "FUBP1" "hsa:8880; Q12828; Q96AE4" "" "" "0" "0" "1.023" "1.020" "1.090" "1.069" "1.030" "1.155" "1.089" "1.026" "0.651" "2516.3" "2574.4" "2566.5" "2743.4" "2689.1" "2591.0" "2905.2" "2739.9" "2582.8" "1639.1" "" "" "" "" "" "" "" "" "" "" "1505.8" "1337.8" "1421.3" "1288.0" "1246.5" "1326.4" "1350.8" "1230.1" "1401.3" "1639.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7989790464056543145" "False" "High" "IsMasterProtein" "Cont_P35527" "Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3" "0.000" "True" "76.056" "25" "12" "49" "11" "623" "62.0" "5.24" "143.47" "12" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00038" "3857; 454664" "ENSG00000171403; ENSPTRG00000009169" "KRT9" "A0A2J8KG96; A0A6D2VYW7; H2QCZ6; hsa:3857; O00109; P35527; ptr:454664; Q0IJ47; Q14665" "" "Formation of the cornified envelope" "2" "0" "0.233" "3.467" "0.370" "0.402" "0.442" "0.328" "0.286" "0.679" "0.750" "1851.1" "430.9" "6418.5" "684.2" "744.6" "817.3" "607.7" "529.5" "1256.2" "1389.1" "" "" "" "" "" "" "" "" "" "" "1107.7" "223.9" "3554.4" "321.2" "345.1" "418.4" "282.6" "237.7" "681.5" "1389.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-795610127174802190" "False" "High" "IsMasterProtein" "P15311" "Ezrin OS=Homo sapiens OX=9606 GN=EZR PE=1 SV=4" "0.000" "False" "76.026" "32" "22" "68" "15" "586" "69.4" "6.27" "186.73" "22" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "7430" "ENSG00000092820" "EZR" "E1P5A8; hsa:7430; P15311; P23714; Q4VX75; Q96CU8; Q9NSJ4" "Pathogenic Escherichia coli infection; AGE/RAGE pathway; VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome; CCL18 signaling pathway; Regulation of actin cytoskeleton; GDNF signaling" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Netrin-1 signaling" "11" "1" "1.209" "1.270" "1.170" "1.160" "1.055" "1.115" "1.032" "1.158" "1.975" "1571.2" "1899.8" "1996.2" "1838.1" "1823.0" "1657.5" "1752.0" "1621.6" "1818.8" "3103.4" "" "" "" "" "" "" "" "" "" "" "940.3" "987.2" "1105.5" "862.9" "845.0" "848.5" "814.6" "728.0" "986.8" "3103.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7575182119282234217" "False" "High" "IsMasterProtein" "P18669" "Phosphoglycerate mutase 1 OS=Homo sapiens OX=9606 GN=PGAM1 PE=1 SV=2" "0.000" "False" "75.835" "46" "9" "112" "9" "254" "28.8" "7.18" "321.25" "9" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf00300" "5223" "ENSG00000171314" "PGAM1" "hsa:5223; P18669; Q9BWC0" "Cori cycle; Metabolic reprogramming in colon cancer; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Neutrophil degranulation; Glycolysis; Gluconeogenesis" "8" "0" "0.981" "0.959" "0.953" "0.988" "0.992" "0.996" "1.023" "1.048" "0.693" "4976.9" "4880.3" "4770.9" "4740.9" "4918.0" "4938.1" "4957.9" "5092.6" "5215.7" "3451.0" "" "" "" "" "" "" "" "" "" "" "2978.4" "2536.1" "2642.0" "2225.7" "2279.6" "2527.9" "2305.3" "2286.3" "2829.8" "3451.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8372900262212064526" "False" "High" "IsMasterProtein" "P09651" "Heterogeneous nuclear ribonucleoprotein A1 OS=Homo sapiens OX=9606 GN=HNRNPA1 PE=1 SV=5" "0.000" "False" "75.647" "43" "14" "114" "11" "372" "38.7" "9.13" "259.19" "14" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11627" "3178" "ENSG00000135486" "HNRNPA1" "A8K4Z8; hsa:3178; P09651; Q3MIB7; Q6PJZ7" "mRNA processing" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; SARS-CoV-1-host interactions; SARS-CoV-1 modulates host translation machinery" "6" "2" "1.032" "1.166" "1.077" "1.131" "1.084" "1.012" "0.982" "1.209" "1.873" "2901.7" "2994.4" "3384.1" "3124.5" "3282.0" "3145.8" "2936.8" "2850.8" "3507.6" "5435.8" "" "" "" "" "" "" "" "" "" "" "1736.5" "1556.1" "1874.0" "1466.9" "1521.3" "1610.4" "1365.6" "1279.8" "1903.0" "5435.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4943408873611006946" "False" "High" "IsMasterProtein" "Q02790" "Peptidyl-prolyl cis-trans isomerase FKBP4 OS=Homo sapiens OX=9606 GN=FKBP4 PE=1 SV=3" "0.000" "False" "75.541" "41" "19" "61" "19" "459" "51.8" "5.43" "146.98" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00254, Pf00515" "2288" "ENSG00000004478" "FKBP4" "D3DUQ1; hsa:2288; Q02790; Q9UCP1; Q9UCV7" "Androgen receptor signaling pathway" "Estrogen-dependent gene expression; Potential therapeutics for SARS; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase" "6" "0" "1.030" "1.162" "1.021" "1.055" "1.094" "1.075" "0.593" "1.154" "6.353" "1976.5" "2035.8" "2296.8" "2017.3" "2085.8" "2163.2" "2123.8" "1171.5" "2281.7" "12555.8" "" "" "" "" "" "" "" "" "" "" "1182.8" "1057.9" "1271.9" "947.1" "966.8" "1107.4" "987.5" "525.9" "1237.9" "12555.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7200124319077870265" "False" "High" "IsMasterProtein" "P35998" "26S proteasome regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMC2 PE=1 SV=3" "0.000" "False" "75.166" "31" "14" "40" "14" "433" "48.6" "5.95" "111.37" "14" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf17862, Pf21236" "5701" "ENSG00000161057" "PSMC2" "A4D0Q1; B7Z5E2; hsa:5701; P35998; Q3LIA5; Q9UDI3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Regulation of expression of SLITs and ROBOs; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Neutrophil degranulation; Downstream TCR signaling; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "1.019" "0.975" "1.040" "1.041" "1.120" "0.994" "1.047" "0.996" "1.067" "1617.8" "1648.7" "1578.1" "1682.5" "1683.5" "1811.2" "1608.5" "1693.5" "1611.0" "1726.4" "" "" "" "" "" "" "" "" "" "" "968.1" "856.8" "873.9" "789.9" "780.3" "927.2" "747.9" "760.3" "874.1" "1726.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1437686464987713845" "False" "High" "IsMasterProtein" "Q9BUF5" "Tubulin beta-6 chain OS=Homo sapiens OX=9606 GN=TUBB6 PE=1 SV=1" "0.000" "False" "75.165" "35" "13" "107" "5" "446" "49.8" "4.88" "240.04" "13" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "84617" "ENSG00000176014" "TUBB6" "B3KM76; hsa:84617; Q9BUF5; Q9HA42" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Prefoldin mediated transfer of substrate to CCT/TriC; Recycling pathway of L1; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; The role of GTSE1 in G2/M progression after G2 checkpoint; Sealing of the nuclear envelope (NE) by ESCRT-III; HCMV Early Events; Post-chaperonin tubulin folding pathway; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Kinesins; PKR-mediated signaling; Hedgehog 'off' state" "35" "0" "0.938" "0.883" "0.859" "0.993" "0.959" "0.903" "1.019" "0.993" "0.669" "388.5" "364.4" "343.2" "333.6" "385.9" "372.7" "350.8" "395.8" "385.9" "259.8" "" "" "" "" "" "" "" "" "" "" "232.5" "189.4" "190.1" "156.6" "178.9" "190.8" "163.1" "177.7" "209.3" "259.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1612190288293860915" "False" "High" "IsMasterProtein" "P60842" "Eukaryotic initiation factor 4A-I OS=Homo sapiens OX=9606 GN=EIF4A1 PE=1 SV=1" "0.000" "False" "74.938" "36" "14" "54" "7" "406" "46.1" "5.48" "161.10" "14" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1973" "ENSG00000161960" "EIF4A1" "B2R6L8; D3DTP9; hsa:1973; J3QLC4; P04765; P60842; Q5U018; Q61516" "Translation factors; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Interferon type I signaling pathways" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ISG15 antiviral mechanism; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "13" "7" "1.001" "0.996" "1.053" "1.051" "1.078" "0.978" "0.851" "1.049" "3.557" "2670.0" "2672.6" "2658.9" "2810.2" "2807.1" "2879.0" "2611.3" "2271.7" "2799.7" "9498.3" "" "" "" "" "" "" "" "" "" "" "1597.8" "1388.8" "1472.4" "1319.3" "1301.1" "1473.8" "1214.2" "1019.8" "1519.0" "9498.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5299836175419688438" "False" "High" "IsMasterProtein" "P42166" "Lamina-associated polypeptide 2, isoform alpha OS=Homo sapiens OX=9606 GN=TMPO PE=1 SV=2" "0.000" "False" "74.664" "22" "13" "29" "13" "694" "75.4" "7.66" "93.28" "13" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03020, Pf08198, Pf11560" "7112" "ENSG00000120802" "TMPO" "P08918; P08919; P42166; Q14860; Q16295" "Envelope proteins and their potential roles in EDMD physiopathology; Overlap between signal transduction pathways contributing to LMNA laminopathies" "" "2" "0" "1.019" "0.981" "1.118" "1.086" "0.982" "1.134" "1.025" "0.988" "1.839" "1127.7" "1149.0" "1106.2" "1261.1" "1224.3" "1107.3" "1278.6" "1155.4" "1114.7" "2074.4" "" "" "" "" "" "" "" "" "" "" "674.9" "597.1" "612.6" "592.0" "567.5" "566.8" "594.5" "518.7" "604.8" "2074.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2015286030572761336" "False" "High" "IsMasterProtein" "P24752" "Acetyl-CoA acetyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAT1 PE=1 SV=1" "0.000" "False" "74.603" "41" "16" "58" "16" "427" "45.2" "8.85" "144.15" "16" "other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion;ER/Golgi" "other molecular function" "Pf00108, Pf02803" "38" "ENSG00000075239" "ACAT1" "B2R6H1; G3XAB4; hsa:38; P24752; Q96FG8" "Fatty acid beta-oxidation; Tryptophan metabolism; SARS-CoV-2 and COVID-19 pathway" "Mitochondrial protein degradation; Branched-chain amino acid catabolism; Utilization of Ketone Bodies; Synthesis of Ketone Bodies" "7" "0" "1.116" "0.933" "0.970" "0.998" "1.008" "0.932" "0.954" "0.976" "0.643" "3278.8" "3657.6" "3060.6" "3181.7" "3273.3" "3303.9" "3057.3" "3127.0" "3201.2" "2109.7" "" "" "" "" "" "" "" "" "" "" "1962.2" "1900.7" "1694.9" "1493.7" "1517.2" "1691.4" "1421.6" "1403.8" "1736.8" "2109.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5288684708523747991" "False" "High" "IsMasterProtein" "Q14240" "Eukaryotic initiation factor 4A-II OS=Homo sapiens OX=9606 GN=EIF4A2 PE=1 SV=2" "0.000" "False" "74.002" "36" "13" "48" "6" "407" "46.4" "5.48" "142.22" "13" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1974" "ENSG00000156976" "EIF4A2" "D3DNU9; hsa:1974; Q14240; Q53XJ6; Q96B90; Q96EA8" "Translation factors; Translation inhibitors in chronically activated PDGFRA cells" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; Z-decay: degradation of maternal mRNAs by zygotically expressed factors; Translation initiation complex formation; Ribosomal scanning and start codon recognition" "11" "0" "1.030" "1.016" "1.049" "1.020" "1.178" "0.911" "1.056" "0.962" "0.888" "1070.4" "1102.3" "1087.5" "1122.4" "1092.2" "1261.3" "974.6" "1130.0" "1030.0" "950.8" "" "" "" "" "" "" "" "" "" "" "640.6" "572.8" "602.3" "526.9" "506.2" "645.7" "453.2" "507.3" "558.8" "950.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4573654140983497752" "False" "High" "IsMasterProtein" "P12004" "Proliferating cell nuclear antigen OS=Homo sapiens OX=9606 GN=PCNA PE=1 SV=1" "0.000" "False" "73.362" "43" "10" "55" "10" "261" "28.8" "4.69" "145.07" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00705, Pf02747" "5111" "ENSG00000132646" "PCNA" "B2R897; D3DW02; hsa:5111; P12004" "Cell cycle; Retinoblastoma gene in cancer; Primary focal segmental glomerulosclerosis (FSGS); Oxidative damage response; EGF/EGFR signaling pathway; G1 to S cell cycle control; DNA replication; Hepatitis B infection; Base excision repair; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; 16p11.2 proximal deletion syndrome; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum ; Urotensin-II-mediated signaling pathway; DNA mismatch repair; 10q11.21q11.23 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; NF1 copy number variation syndrome ; Rubinstein-Taybi syndrome 1" "HDR through Homologous Recombination (HRR); E3 ubiquitin ligases ubiquitinate target proteins; SUMOylation of DNA replication proteins; Termination of translesion DNA synthesis; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; G1/S-Specific Transcription; Recognition of DNA damage by PCNA-containing replication complex; Transcription of E2F targets under negative control by DREAM complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "47" "0" "1.011" "1.045" "1.036" "0.976" "1.084" "0.967" "1.186" "1.051" "0.873" "4105.9" "4152.3" "4289.6" "4252.1" "4005.7" "4451.8" "3971.6" "4869.4" "4313.2" "3583.8" "" "" "" "" "" "" "" "" "" "" "2457.1" "2157.8" "2375.5" "1996.3" "1856.7" "2279.0" "1846.7" "2186.1" "2340.1" "3583.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "114843226561293462" "False" "High" "IsMasterProtein" "P67936" "Tropomyosin alpha-4 chain OS=Homo sapiens OX=9606 GN=TPM4 PE=1 SV=3" "0.000" "False" "73.185" "50" "15" "68" "8" "248" "28.5" "4.69" "185.77" "15" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00261" "7171" "ENSG00000167460" "TPM4" "hsa:7171; P07226; P67936; Q15659; Q5U0D9; Q9BU85; Q9H8Q3; Q9UCS1; Q9UCS2; Q9UCS3; Q9UCS4" "Striated muscle contraction pathway" "Signaling by ALK fusions and activated point mutants; RHOV GTPase cycle; Smooth Muscle Contraction; Striated Muscle Contraction" "5" "7" "0.962" "0.906" "0.909" "0.909" "0.853" "1.002" "0.988" "0.862" "0.400" "6736.0" "6480.9" "6103.7" "6123.1" "6123.1" "5744.8" "6749.8" "6654.8" "5807.4" "2693.5" "" "" "" "" "" "" "" "" "" "" "4031.1" "3367.9" "3380.1" "2874.6" "2838.2" "2940.9" "3138.5" "2987.6" "3150.7" "2693.5" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4198310778640922638" "False" "High" "IsMasterProtein" "Q9Y3F4" "Serine-threonine kinase receptor-associated protein OS=Homo sapiens OX=9606 GN=STRAP PE=1 SV=1" "0.000" "False" "72.826" "33" "10" "30" "10" "350" "38.4" "5.12" "98.88" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00400" "11171" "ENSG00000023734" "STRAP" "B2R5S5; B4DNJ6; hsa:11171; Q5TZT4; Q9NTK0; Q9UQC8; Q9Y3F4" "TGF-beta signaling pathway; Epithelial to mesenchymal transition in colorectal cancer" "Downregulation of TGF-beta receptor signaling" "3" "0" "1.011" "0.975" "0.998" "1.005" "1.024" "0.973" "0.980" "1.040" "1.010" "2608.9" "2637.3" "2543.0" "2604.4" "2621.4" "2671.2" "2537.7" "2556.0" "2713.6" "2635.1" "" "" "" "" "" "" "" "" "" "" "1561.3" "1370.5" "1408.3" "1222.7" "1215.1" "1367.4" "1180.0" "1147.5" "1472.2" "2635.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4535556334998408323" "False" "High" "IsMasterProtein" "P49411" "Elongation factor Tu, mitochondrial OS=Homo sapiens OX=9606 GN=TUFM PE=1 SV=3" "0.000" "False" "72.699" "32" "14" "39" "14" "455" "49.8" "7.61" "109.00" "14" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "7284" "ENSG00000178952" "TUFM" "hsa:7284; O15276; P49411" "16p11.2 distal deletion syndrome" "Mitochondrial translation elongation; SARS-CoV-2 modulates autophagy" "3" "0" "1.043" "1.015" "1.140" "1.137" "1.084" "1.043" "0.640" "1.013" "6.443" "1222.5" "1274.9" "1240.4" "1394.1" "1390.0" "1324.9" "1275.5" "781.9" "1238.5" "7876.3" "" "" "" "" "" "" "" "" "" "" "731.6" "662.5" "686.9" "654.5" "644.3" "678.3" "593.1" "351.0" "672.0" "7876.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3353104297975983136" "False" "High" "IsMasterProtein" "O43242" "26S proteasome non-ATPase regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PSMD3 PE=1 SV=2" "0.000" "False" "72.461" "28" "15" "48" "15" "534" "60.9" "8.44" "141.83" "15" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01399, Pf08375" "5709" "ENSG00000108344" "PSMD3" "B3KMW9; B4DT72; hsa:5709; O43242; Q96EI2; Q9BQA4" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Interleukin-1 signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "0.984" "0.920" "1.013" "1.000" "1.031" "0.997" "1.110" "0.996" "0.770" "3357.6" "3304.5" "3089.6" "3399.8" "3359.2" "3462.6" "3348.6" "3725.6" "3342.7" "2584.0" "" "" "" "" "" "" "" "" "" "" "2009.3" "1717.2" "1711.0" "1596.1" "1557.1" "1772.6" "1557.0" "1672.6" "1813.6" "2584.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3994958122545782914" "False" "High" "IsMasterProtein" "Cont_Q9XSJ4" "Alpha-enolase OS=Bos taurus OX=9913 GN=ENO1 PE=1 SV=4" "0.000" "True" "72.040" "33" "12" "111" "1" "434" "47.3" "6.80" "298.58" "12" "other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00113, Pf03952" "281141" "" "ENO1" "bta:281141; Q3SYW4; Q9XSJ4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6681537936157474887" "False" "High" "IsMasterProtein" "Q9UH65" "Switch-associated protein 70 OS=Homo sapiens OX=9606 GN=SWAP70 PE=1 SV=1" "0.000" "False" "72.025" "27" "19" "37" "18" "585" "69.0" "5.87" "103.84" "19" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00169" "23075" "ENSG00000133789" "SWAP70" "D3DQV1; hsa:23075; O75135; Q7LCY6; Q9P061; Q9P0Z8; Q9UH65" "" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle" "3" "0" "1.084" "1.037" "1.038" "0.936" "0.999" "0.929" "0.956" "0.960" "0.869" "2839.4" "3077.8" "2944.8" "2945.9" "2658.3" "2837.2" "2636.8" "2713.4" "2726.3" "2468.4" "" "" "" "" "" "" "" "" "" "" "1699.2" "1599.4" "1630.8" "1383.0" "1232.2" "1452.4" "1226.0" "1218.2" "1479.1" "2468.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8312610725791659305" "False" "High" "IsMasterProtein" "P17812" "CTP synthase 1 OS=Homo sapiens OX=9606 GN=CTPS1 PE=1 SV=2" "0.000" "False" "71.921" "32" "19" "33" "16" "591" "66.6" "6.46" "90.65" "19" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00117, Pf06418, Pf07722" "1503" "ENSG00000171793" "CTPS1" "B4DR64; D3DPW1; hsa:1503; P17812; Q5VW67; Q96GK6" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "2" "0.898" "0.871" "0.977" "0.932" "0.928" "0.992" "0.963" "1.023" "0.691" "1704.9" "1530.5" "1485.5" "1666.0" "1588.8" "1582.6" "1690.9" "1641.8" "1743.9" "1178.7" "" "" "" "" "" "" "" "" "" "" "1020.3" "795.3" "822.6" "782.1" "736.4" "810.2" "786.2" "737.1" "946.1" "1178.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6979633451004201219" "False" "High" "IsMasterProtein" "P31946" "14-3-3 protein beta/alpha OS=Homo sapiens OX=9606 GN=YWHAB PE=1 SV=3" "0.000" "False" "71.893" "53" "12" "143" "5" "246" "28.1" "4.83" "364.48" "12" "signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00244" "7529" "ENSG00000166913" "YWHAB" "A8K9K2; E1P616; hsa:7529; P31946" "Cell cycle; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Hepatitis B infection; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Regulation of localization of FOXO transcription factors; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Signaling by Hippo; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Rap1 signalling; Negative regulation of MAPK pathway; Frs2-mediated activation; ARMS-mediated activation; Activation of BAD and translocation to mitochondria ; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "33" "0" "1.045" "1.098" "1.073" "1.157" "1.057" "1.169" "1.163" "1.202" "0.851" "1065.8" "1113.5" "1170.4" "1143.3" "1233.6" "1126.8" "1245.5" "1239.1" "1280.8" "907.5" "" "" "" "" "" "" "" "" "" "" "637.8" "578.6" "648.1" "536.7" "571.8" "576.9" "579.1" "556.3" "694.9" "907.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1547781430018805415" "False" "High" "IsMasterProtein" "P30101" "Protein disulfide-isomerase A3 OS=Homo sapiens OX=9606 GN=PDIA3 PE=1 SV=4" "0.000" "False" "71.722" "32" "15" "47" "15" "505" "56.7" "6.35" "123.57" "15" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00085, Pf13848" "2923" "ENSG00000167004" "PDIA3" "hsa:2923; P30101; Q13453; Q14255; Q8IYF8; Q9UMU7" "Prion disease pathway" "ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle" "4" "0" "0.941" "1.023" "0.950" "0.982" "0.978" "0.919" "0.706" "1.011" "3.477" "1666.7" "1568.5" "1705.0" "1582.8" "1636.5" "1630.5" "1530.9" "1177.2" "1684.6" "5795.1" "" "" "" "" "" "" "" "" "" "" "997.4" "815.1" "944.2" "743.1" "758.5" "834.7" "711.8" "528.5" "914.0" "5795.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5359713146649655482" "False" "High" "IsMasterProtein" "P31150" "Rab GDP dissociation inhibitor alpha OS=Homo sapiens OX=9606 GN=GDI1 PE=1 SV=2" "0.000" "False" "71.434" "36" "14" "52" "9" "447" "50.6" "5.14" "123.42" "14" "cell organization and biogenesis;transport;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "2664" "ENSG00000203879" "GDI1" "hsa:2664; P31150; P50394; Q6FG50; Q7Z2G6; Q7Z2G9; Q7Z2H5; Q7Z2I6" "Ciliary landscape; Airway smooth muscle cell contraction" "RAB GEFs exchange GTP for GDP on RABs" "3" "0" "1.096" "1.091" "1.200" "1.165" "1.192" "1.130" "1.223" "1.043" "0.945" "438.8" "480.7" "478.6" "526.5" "511.3" "523.0" "495.9" "536.5" "457.8" "414.8" "" "" "" "" "" "" "" "" "" "" "262.6" "249.8" "265.0" "247.2" "237.0" "267.7" "230.6" "240.9" "248.4" "414.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7543503445909431130" "False" "High" "IsMasterProtein" "P13798" "Acylamino-acid-releasing enzyme OS=Homo sapiens OX=9606 GN=APEH PE=1 SV=4" "0.000" "False" "71.371" "20" "14" "46" "14" "732" "81.2" "5.48" "117.60" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00326, Pf19283" "327" "ENSG00000164062" "APEH" "hsa:327; P13798; Q9BQ33; Q9P0Y2" "" "Neutrophil degranulation; Eukaryotic Translation Termination" "2" "0" "0.912" "0.932" "0.980" "0.910" "0.928" "0.912" "0.970" "0.857" "0.549" "1951.7" "1780.9" "1819.5" "1912.2" "1776.6" "1811.7" "1779.2" "1893.8" "1672.4" "1072.1" "" "" "" "" "" "" "" "" "" "" "1168.0" "925.4" "1007.6" "897.7" "823.5" "927.4" "827.3" "850.2" "907.4" "1072.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1156142612126302656" "False" "High" "IsMasterProtein" "P07814" "Bifunctional glutamate/proline--tRNA ligase OS=Homo sapiens OX=9606 GN=EPRS1 PE=1 SV=5" "0.000" "False" "71.248" "12" "16" "20" "15" "1512" "170.5" "7.33" "60.76" "16" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00458, Pf00587, Pf00749, Pf03129, Pf03950, Pf09180, Pf20974" "2058" "ENSG00000136628" "EPRS1" "A0AVA9; B9EGH3; hsa:2058; P07814; Q05BP6; Q05DF8; Q5DSM1; Q5H9S5; Q6PD57; Q86X73" "Parkinson's disease pathway; VEGFA-VEGFR2 signaling; Amino acid metabolism" "tRNA modification in the nucleus and cytosol; Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "6" "1" "1.025" "1.014" "1.023" "1.012" "1.144" "1.012" "0.466" "1.059" "8.807" "668.3" "684.7" "677.6" "683.6" "676.2" "764.2" "676.2" "311.5" "707.6" "5885.7" "" "" "" "" "" "" "" "" "" "" "399.9" "355.8" "375.3" "321.0" "313.4" "391.2" "314.4" "139.9" "383.9" "5885.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6739542972395274555" "False" "High" "IsMasterProtein" "Q9P265" "Disco-interacting protein 2 homolog B OS=Homo sapiens OX=9606 GN=DIP2B PE=1 SV=3" "0.000" "False" "71.056" "13" "17" "28" "17" "1576" "171.4" "8.09" "81.58" "17" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity" "Pf00501, Pf06464" "57609" "ENSG00000066084" "DIP2B" "hsa:57609; Q6B011; Q8N1L5; Q8NB38; Q9P265" "" "" "0" "0" "1.021" "1.120" "1.066" "1.028" "1.075" "1.010" "1.115" "1.009" "0.798" "637.2" "650.8" "713.4" "679.4" "655.0" "684.9" "643.4" "710.7" "642.8" "508.3" "" "" "" "" "" "" "" "" "" "" "381.3" "338.2" "395.0" "319.0" "303.6" "350.6" "299.1" "319.1" "348.7" "508.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "563058972091496350" "False" "High" "IsMasterProtein" "P80723" "Brain acid soluble protein 1 OS=Homo sapiens OX=9606 GN=BASP1 PE=1 SV=2" "0.000" "False" "70.714" "50" "8" "15" "8" "227" "22.7" "4.63" "54.47" "8" "developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05466" "10409" "ENSG00000176788" "BASP1" "B4DJA8; D3DTD5; hsa:10409; O43596; P80723; Q5U0S0; Q9BWA5" "" "RHOF GTPase cycle" "1" "0" "1.103" "0.971" "1.022" "1.039" "1.093" "1.059" "1.200" "1.111" "0.457" "905.9" "999.5" "879.2" "925.4" "941.1" "990.2" "959.4" "1086.6" "1006.1" "414.0" "" "" "" "" "" "" "" "" "" "" "542.1" "519.4" "486.9" "434.5" "436.2" "506.9" "446.1" "487.8" "545.9" "414.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4081821255654730279" "False" "High" "IsMasterProtein" "Q13618" "Cullin-3 OS=Homo sapiens OX=9606 GN=CUL3 PE=1 SV=2" "0.000" "False" "70.573" "21" "17" "47" "17" "768" "88.9" "8.48" "111.53" "17" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00888, Pf10557" "8452" "ENSG00000036257" "CUL3" "A8K536; B8ZZC3; hsa:8452; O75415; Q13618; Q569L3; Q9UBI8; Q9UET7" "Hereditary leiomyomatosis and renal cell carcinoma pathway; Hedgehog signaling pathway; NRF2-ARE regulation; 22q11.2 copy number variation syndrome; Head and neck squamous cell carcinoma; 1p36 copy number variation syndrome" "Potential therapeutics for SARS; Antigen processing: Ubiquitination & Proteasome degradation; Degradation of DVL; Hedgehog 'on' state; Regulation of RAS by GAPs; Neddylation; KEAP1-NFE2L2 pathway; RHOBTB3 ATPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "16" "0" "1.061" "0.999" "1.110" "1.115" "1.071" "1.069" "1.107" "1.044" "0.658" "1782.7" "1891.6" "1781.3" "1978.7" "1988.0" "1910.0" "1906.1" "1973.8" "1860.6" "1173.1" "" "" "" "" "" "" "" "" "" "" "1066.8" "983.0" "986.4" "928.9" "921.5" "977.8" "886.3" "886.1" "1009.5" "1173.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2100878916131084887" "False" "High" "IsMasterProtein" "P36871" "Phosphoglucomutase-1 OS=Homo sapiens OX=9606 GN=PGM1 PE=1 SV=3" "0.000" "False" "70.259" "28" "15" "36" "15" "562" "61.4" "6.76" "96.74" "15" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf02878, Pf02879, Pf02880" "5236" "ENSG00000079739" "PGM1" "B2R5N9; B4DPV0; hsa:5236; P36871; Q16105; Q16106; Q5BKZ9; Q6NW22; Q86U74; Q96J40; Q9NTY4" "Ectoderm differentiation; Clear cell renal cell carcinoma pathways; Glycogen synthesis and degradation; Opioid receptor pathways; Disorders of galactose metabolism ; Disorders of fructose metabolism; UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "Neutrophil degranulation; Glycogen synthesis; Glycogen breakdown (glycogenolysis); Galactose catabolism; Defective PGM1 causes PGM1-CDG" "13" "0" "0.967" "0.930" "1.033" "0.955" "0.977" "0.995" "1.062" "0.983" "0.580" "2640.1" "2553.2" "2454.0" "2726.7" "2520.0" "2580.5" "2626.9" "2803.5" "2594.4" "1530.1" "" "" "" "" "" "" "" "" "" "" "1580.0" "1326.8" "1359.0" "1280.1" "1168.1" "1321.0" "1221.5" "1258.6" "1407.6" "1530.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "964900113043376779" "False" "High" "IsMasterProtein" "Q9Y265" "RuvB-like 1 OS=Homo sapiens OX=9606 GN=RUVBL1 PE=1 SV=1" "0.000" "False" "70.060" "30" "11" "25" "11" "456" "50.2" "6.42" "68.16" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06068, Pf17856" "8607" "ENSG00000175792" "RUVBL1" "B2R5S0; hsa:8607; P82276; Q1KMR0; Q53HK5; Q53HL7; Q53Y27; Q9BSX9; Q9Y265" "Gastric cancer network 1; lncRNA in canonical Wnt signaling and colorectal cancer" "UCH proteinases; Ub-specific processing proteases; Deposition of new CENPA-containing nucleosomes at the centromere; Formation of the beta-catenin:TCF transactivating complex; Telomere Extension By Telomerase; HATs acetylate histones; DNA Damage Recognition in GG-NER" "9" "0" "1.019" "0.921" "0.968" "0.890" "0.926" "0.918" "0.949" "0.923" "0.907" "1808.8" "1843.3" "1666.6" "1750.7" "1609.6" "1675.3" "1660.0" "1716.3" "1670.2" "1640.9" "" "" "" "" "" "" "" "" "" "" "1082.5" "957.9" "922.9" "821.9" "746.1" "857.6" "771.8" "770.5" "906.2" "1640.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9133260577685858014" "False" "High" "IsMasterProtein" "O00410" "Importin-5 OS=Homo sapiens OX=9606 GN=IPO5 PE=1 SV=4" "0.000" "False" "69.674" "21" "18" "51" "18" "1097" "123.6" "4.94" "105.04" "18" "transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02985, Pf18808, Pf18816, Pf18829" "3843" "ENSG00000065150" "IPO5" "B4DZA0; hsa:3843; O00410; O15257; Q5T578; Q86XC7" "" "vRNP Assembly" "1" "0" "1.139" "1.109" "1.084" "1.204" "1.138" "1.176" "1.126" "1.126" "1.934" "880.9" "1003.8" "977.1" "954.9" "1060.3" "1002.3" "1036.1" "992.0" "992.0" "1703.7" "" "" "" "" "" "" "" "" "" "" "527.2" "521.6" "541.1" "448.3" "491.5" "513.1" "481.8" "445.4" "538.2" "1703.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9171365705039643338" "False" "High" "IsMasterProtein" "P45974" "Ubiquitin carboxyl-terminal hydrolase 5 OS=Homo sapiens OX=9606 GN=USP5 PE=1 SV=2" "0.000" "False" "69.624" "21" "18" "40" "18" "858" "95.7" "5.03" "88.96" "18" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf00443, Pf00627, Pf02148, Pf17807" "8078" "ENSG00000111667" "USP5" "D3DUS7; D3DUS8; hsa:8078; P45974; Q96J22" "IL-18 signaling pathway" "Ub-specific processing proteases; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "3" "0" "1.145" "1.086" "1.128" "1.119" "1.155" "1.064" "1.096" "1.085" "1.296" "940.8" "1076.8" "1021.4" "1061.4" "1052.5" "1086.6" "1000.9" "1031.2" "1020.6" "1219.4" "" "" "" "" "" "" "" "" "" "" "563.0" "559.6" "565.6" "498.3" "487.8" "556.3" "465.4" "463.0" "553.7" "1219.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8431694603937659134" "False" "High" "IsMasterProtein" "P15531" "Nucleoside diphosphate kinase A OS=Homo sapiens OX=9606 GN=NME1 PE=1 SV=1" "0.000" "False" "69.401" "58" "9" "118" "4" "152" "17.1" "6.19" "357.45" "9" "DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "translation activity;kinase activity;other molecular function" "Pf00334" "4830" "ENSG00000239672" "NME1" "hsa:4830; P15531; Q6FGK3; Q86XQ2; Q9UDJ6" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates; Azathioprine ADME; Ribavirin ADME" "4" "0" "0.999" "1.003" "0.990" "0.991" "1.008" "0.966" "1.057" "0.994" "0.666" "3223.3" "3218.8" "3232.7" "3191.7" "3193.5" "3248.5" "3114.6" "3406.2" "3203.3" "2145.2" "" "" "" "" "" "" "" "" "" "" "1929.0" "1672.7" "1790.2" "1498.4" "1480.3" "1663.0" "1448.2" "1529.2" "1737.9" "2145.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2327422208095163378" "False" "High" "IsMasterProtein" "P35749" "Myosin-11 OS=Homo sapiens OX=9606 GN=MYH11 PE=1 SV=3" "0.000" "False" "69.385" "10" "18" "32" "8" "1972" "227.2" "5.50" "87.37" "18" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf01576, Pf02736" "4629" "ENSG00000133392; ENSG00000276480" "MYH11" "D2JYH7; hsa:4629; O00396; O94944; P35749; P78422; Q3MIV8; Q3MNF0; Q3MNF1" "VEGFA-VEGFR2 signaling" "RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "8" "0" "1.232" "1.108" "1.284" "1.487" "1.375" "1.022" "0.971" "1.153" "3.073" "80.9" "99.7" "89.7" "104.0" "120.4" "111.3" "82.7" "78.6" "93.4" "248.7" "" "" "" "" "" "" "" "" "" "" "48.4" "51.8" "49.7" "48.8" "55.8" "57.0" "38.5" "35.3" "50.6" "248.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8302543892740036521" "False" "High" "IsMasterProtein" "P82970" "High mobility group nucleosome-binding domain-containing protein 5 OS=Homo sapiens OX=9606 GN=HMGN5 PE=1 SV=1" "0.000" "False" "69.305" "33" "10" "29" "10" "282" "31.5" "4.55" "92.52" "10" "cell organization and biogenesis;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "79366" "ENSG00000198157" "HMGN5" "hsa:79366; P82970; Q5JSL1" "" "" "0" "0" "1.101" "1.096" "1.091" "1.163" "1.162" "1.062" "1.296" "1.060" "0.471" "3822.3" "4206.5" "4190.3" "4169.1" "4446.1" "4443.0" "4058.1" "4953.8" "4052.3" "1801.5" "" "" "" "" "" "" "" "" "" "" "2287.4" "2186.0" "2320.5" "1957.3" "2060.9" "2274.5" "1887.0" "2224.0" "2198.5" "1801.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5272993671693515484" "False" "High" "IsMasterProtein" "Q15181" "Inorganic pyrophosphatase OS=Homo sapiens OX=9606 GN=PPA1 PE=1 SV=2" "0.000" "False" "69.146" "45" "11" "58" "10" "289" "32.6" "5.86" "151.22" "11" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00719" "5464" "ENSG00000180817" "PPA1" "hsa:5464; Q15181; Q2M348; Q5SQT7; Q6P7P4; Q9UQJ5; Q9Y5B1" "" "Cytosolic tRNA aminoacylation; Pyrophosphate hydrolysis" "2" "1" "1.061" "1.092" "0.979" "1.085" "1.031" "1.007" "1.045" "1.105" "0.667" "2334.6" "2476.5" "2550.2" "2284.7" "2533.4" "2405.9" "2351.0" "2439.3" "2580.3" "1557.3" "" "" "" "" "" "" "" "" "" "" "1397.1" "1286.9" "1412.3" "1072.6" "1174.3" "1231.6" "1093.2" "1095.1" "1399.9" "1557.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "479686062085054609" "False" "High" "IsMasterProtein" "Q15365" "Poly(rC)-binding protein 1 OS=Homo sapiens OX=9606 GN=PCBP1 PE=1 SV=2" "0.000" "False" "68.939" "45" "11" "42" "7" "356" "37.5" "7.09" "102.41" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "5093" "ENSG00000169564" "PCBP1" "hsa:5093; Q13157; Q14975; Q15365" "Ferroptosis" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "3" "4" "1.078" "1.158" "1.150" "1.151" "1.196" "1.162" "0.805" "1.110" "4.467" "1105.4" "1191.6" "1279.7" "1270.7" "1272.7" "1322.5" "1284.4" "890.4" "1227.0" "4938.1" "" "" "" "" "" "" "" "" "" "" "661.5" "619.2" "708.7" "596.6" "589.9" "677.0" "597.2" "399.7" "665.7" "4938.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7742249596596208262" "False" "High" "IsMasterProtein" "Q7KZF4" "Staphylococcal nuclease domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SND1 PE=1 SV=1" "0.000" "False" "68.935" "20" "18" "33" "18" "910" "101.9" "7.17" "90.48" "18" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00565, Pf00567" "27044" "ENSG00000197157" "SND1" "hsa:27044; Q13122; Q7KZF4; Q96AG0" "VEGFA-VEGFR2 signaling" "Signaling by BRAF and RAF1 fusions" "2" "0" "1.000" "1.102" "1.184" "1.158" "1.049" "1.126" "0.448" "1.128" "10.120" "804.5" "804.6" "886.2" "952.2" "931.6" "844.1" "905.9" "360.2" "907.3" "8141.4" "" "" "" "" "" "" "" "" "" "" "481.4" "418.1" "490.8" "447.0" "431.8" "432.1" "421.2" "161.7" "492.2" "8141.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2214005141303334461" "False" "High" "IsMasterProtein" "P12956" "X-ray repair cross-complementing protein 6 OS=Homo sapiens OX=9606 GN=XRCC6 PE=1 SV=2" "0.000" "False" "68.867" "28" "16" "30" "16" "609" "69.8" "6.64" "72.16" "16" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf02735, Pf03730, Pf03731" "2547" "ENSG00000196419" "XRCC6" "B1AHC8; hsa:2547; P12956; Q6FG89; Q9UCQ2; Q9UCQ3" "Non-homologous end joining; DNA repair pathways, full network; Primary ovarian insufficiency; HDAC6 interactions in the central nervous system" "Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN" "9" "0" "0.933" "1.061" "1.020" "1.053" "0.980" "0.876" "0.405" "1.051" "6.735" "940.5" "877.4" "998.2" "959.5" "990.6" "921.3" "823.6" "381.2" "988.3" "6334.6" "" "" "" "" "" "" "" "" "" "" "562.8" "455.9" "552.8" "450.5" "459.2" "471.6" "383.0" "171.1" "536.2" "6334.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1964707792463719030" "False" "High" "IsMasterProtein" "O43776" "Asparagine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=NARS1 PE=1 SV=1" "0.000" "False" "68.755" "30" "16" "39" "16" "548" "62.9" "6.25" "106.72" "16" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00152, Pf01336, Pf20917" "4677" "ENSG00000134440" "NARS1" "B4DG16; hsa:4677; O43776; Q53GU6" "Photodynamic therapy-induced unfolded protein response" "Cytosolic tRNA aminoacylation" "2" "0" "0.933" "0.912" "0.972" "0.895" "0.958" "0.901" "0.936" "0.911" "0.633" "2366.3" "2208.1" "2158.9" "2300.6" "2117.9" "2267.7" "2133.1" "2214.3" "2154.7" "1496.9" "" "" "" "" "" "" "" "" "" "" "1416.1" "1147.4" "1195.6" "1080.1" "981.7" "1160.9" "991.8" "994.1" "1169.0" "1496.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6518875519697934580" "False" "High" "IsMasterProtein" "Q92576" "PHD finger protein 3 OS=Homo sapiens OX=9606 GN=PHF3 PE=1 SV=3" "0.000" "False" "68.564" "10" "18" "22" "18" "2039" "229.3" "6.96" "58.19" "18" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00628, Pf07500, Pf07744" "23469" "ENSG00000118482" "PHF3" "A3KFI8; hsa:23469; Q14CR5; Q5CZI1; Q5T1T6; Q92576; Q9NQ16; Q9UI45" "" "" "0" "0" "1.180" "1.098" "1.090" "1.151" "1.208" "1.163" "1.199" "1.126" "0.824" "611.3" "721.0" "671.0" "666.6" "703.4" "738.4" "711.2" "732.9" "688.5" "503.7" "" "" "" "" "" "" "" "" "" "" "365.8" "374.7" "371.6" "312.9" "326.0" "378.0" "330.7" "329.0" "373.5" "503.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7644877244443849971" "False" "High" "IsMasterProtein" "Q13177" "Serine/threonine-protein kinase PAK 2 OS=Homo sapiens OX=9606 GN=PAK2 PE=1 SV=3" "0.000" "False" "68.563" "27" "13" "71" "13" "524" "58.0" "5.96" "187.81" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00786" "5062" "ENSG00000180370" "PAK2" "hsa:5062; Q13154; Q13177; Q6ISC3" "Integrin-mediated cell adhesion; Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; MET in type 1 papillary renal cell carcinoma; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 3q29 copy number variation syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOH GTPase cycle; Nef and signal transduction; Generation of second messenger molecules; Regulation of activated PAK-2p34 by proteasome mediated degradation; MAPK6/MAPK4 signaling; FCERI mediated MAPK activation; Regulation of PAK-2p34 activity by PS-GAP/RHG10; RHOV GTPase cycle; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; RHOU GTPase cycle; Ephrin signaling; Sema3A PAK dependent Axon repulsion; Smooth Muscle Contraction; RHO GTPases activate PAKs; VEGFR2 mediated vascular permeability; Activation of RAC1; CD209 (DC-SIGN) signaling; CD28 dependent Vav1 pathway; Stimulation of the cell death response by PAK-2p34" "45" "0" "1.038" "0.996" "1.013" "0.979" "0.976" "0.987" "0.991" "1.000" "0.674" "6127.2" "6362.4" "6101.0" "6205.2" "5997.1" "5980.3" "6050.2" "6071.6" "6124.3" "4130.8" "" "" "" "" "" "" "" "" "" "" "3666.8" "3306.3" "3378.6" "2913.2" "2779.7" "3061.5" "2813.2" "2725.8" "3322.7" "4130.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-719373628240286726" "False" "High" "IsMasterProtein" "O00231" "26S proteasome non-ATPase regulatory subunit 11 OS=Homo sapiens OX=9606 GN=PSMD11 PE=1 SV=3" "0.000" "False" "68.499" "36" "15" "26" "15" "422" "47.4" "6.48" "82.05" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01399, Pf18055, Pf18503" "5717" "ENSG00000108671" "PSMD11" "A8K3I7; E1P663; hsa:5717; O00231; O00495; Q53FT5" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling" "Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "0.986" "0.918" "0.967" "0.978" "1.050" "1.023" "1.052" "1.083" "0.704" "1480.9" "1459.5" "1359.7" "1431.8" "1447.7" "1555.0" "1515.2" "1557.4" "1604.4" "1042.1" "" "" "" "" "" "" "" "" "" "" "886.2" "758.4" "753.0" "672.2" "671.0" "796.1" "704.5" "699.2" "870.5" "1042.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3509050462547548554" "False" "High" "IsMasterProtein" "Q04917" "14-3-3 protein eta OS=Homo sapiens OX=9606 GN=YWHAH PE=1 SV=4" "0.000" "False" "68.145" "48" "11" "106" "7" "246" "28.2" "4.84" "283.85" "11" "other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00244" "7533" "ENSG00000128245" "YWHAH" "hsa:7533; Q04917" "Cell cycle; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "11" "0" "1.101" "1.143" "1.002" "1.144" "1.106" "1.025" "1.129" "1.118" "1.091" "798.0" "878.7" "912.3" "799.7" "913.0" "882.2" "818.0" "901.0" "892.0" "870.6" "" "" "" "" "" "" "" "" "" "" "477.5" "456.6" "505.2" "375.4" "423.2" "451.6" "380.3" "404.5" "483.9" "870.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2386724705728610253" "False" "High" "IsMasterProtein" "Q9UHB6" "LIM domain and actin-binding protein 1 OS=Homo sapiens OX=9606 GN=LIMA1 PE=1 SV=1" "0.000" "False" "68.072" "22" "15" "21" "15" "759" "85.2" "6.84" "50.79" "15" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412" "51474" "ENSG00000050405" "LIMA1" "B2RB09; hsa:51474; Q2TAN7; Q59FE8; Q9BVF2; Q9H8J1; Q9HBN5; Q9NX96; Q9NXC3; Q9NXU6; Q9P0H8; Q9UHB5; Q9UHB6" "" "" "0" "0" "0.995" "0.959" "0.944" "0.920" "0.818" "1.104" "1.056" "0.911" "0.391" "1190.6" "1185.1" "1142.3" "1124.0" "1095.5" "973.5" "1313.9" "1256.9" "1084.3" "465.2" "" "" "" "" "" "" "" "" "" "" "712.5" "615.9" "632.6" "527.7" "507.8" "498.3" "610.9" "564.3" "588.3" "465.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5232006824815591416" "False" "High" "IsMasterProtein" "P14317" "Hematopoietic lineage cell-specific protein OS=Homo sapiens OX=9606 GN=HCLS1 PE=1 SV=3" "0.000" "False" "67.902" "26" "13" "54" "13" "486" "54.0" "4.81" "163.72" "13" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf02218" "3059" "ENSG00000180353" "HCLS1" "B4DQ69; hsa:3059; P14317; Q53Y93; Q6IBK9; Q9UDK0" "Pathogenic Escherichia coli infection; B cell receptor signaling pathway; TYROBP causal network in microglia" "" "3" "0" "1.001" "0.971" "0.884" "0.985" "1.002" "1.008" "1.040" "1.038" "0.551" "4352.0" "4357.9" "4225.1" "3848.7" "4285.1" "4360.3" "4384.9" "4524.9" "4516.4" "2397.6" "" "" "" "" "" "" "" "" "" "" "2604.4" "2264.6" "2339.8" "1806.9" "1986.2" "2232.2" "2038.9" "2031.4" "2450.4" "2397.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4317219429199659424" "False" "High" "IsMasterProtein" "Q9H6Z4" "Ran-binding protein 3 OS=Homo sapiens OX=9606 GN=RANBP3 PE=1 SV=1" "0.000" "False" "67.725" "30" "13" "31" "13" "567" "60.2" "4.78" "77.96" "13" "transport" "nucleus;other cell component" "other molecular function" "Pf00638" "8498" "ENSG00000031823" "RANBP3" "B2RAT8; hsa:8498; O60405; O75759; O75760; Q9BT47; Q9H6Z4; Q9UG74" "" "" "0" "0" "1.027" "1.051" "1.053" "1.000" "1.042" "1.035" "1.066" "0.963" "0.590" "1393.9" "1431.4" "1465.1" "1467.5" "1393.4" "1453.0" "1442.1" "1486.1" "1342.2" "822.8" "" "" "" "" "" "" "" "" "" "" "834.2" "743.8" "811.3" "689.0" "645.9" "743.8" "670.5" "667.2" "728.2" "822.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4866414538171077072" "False" "High" "IsMasterProtein" "P31146" "Coronin-1A OS=Homo sapiens OX=9606 GN=CORO1A PE=1 SV=4" "0.000" "False" "67.663" "26" "13" "37" "13" "461" "51.0" "6.68" "113.76" "13" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf08954, Pf16300" "11151" "ENSG00000102879" "CORO1A" "B2RBL1; hsa:11151; P31146; Q2YD73" "16p11.2 proximal deletion syndrome" "Prevention of phagosomal-lysosomal fusion" "2" "0" "1.088" "1.092" "1.186" "1.157" "1.081" "1.097" "0.320" "1.171" "10.748" "1221.2" "1329.2" "1333.0" "1448.1" "1413.5" "1319.5" "1340.0" "390.3" "1430.4" "13125.6" "" "" "" "" "" "" "" "" "" "" "730.8" "690.7" "738.2" "679.9" "655.2" "675.5" "623.1" "175.2" "776.0" "13125.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7002487047349753336" "False" "High" "IsMasterProtein" "P22392" "Nucleoside diphosphate kinase B OS=Homo sapiens OX=9606 GN=NME2 PE=1 SV=1" "0.000" "False" "67.598" "59" "10" "123" "1" "152" "17.3" "8.41" "360.17" "10" "cell adhesion;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00334" "4831; 654364" "ENSG00000243678" "NME2" "A8MWA3; hsa:4831; hsa:654364; P22392; Q1WM23; Q6LCT6" "Pyrimidine metabolism" "Azathioprine ADME; Neutrophil degranulation; Interconversion of nucleotide di- and triphosphates; Ribavirin ADME" "5" "9" "0.955" "1.016" "1.007" "0.955" "1.002" "1.038" "1.045" "1.033" "0.625" "13293.7" "12693.0" "13510.2" "13382.6" "12694.5" "13314.4" "13802.7" "13894.3" "13730.4" "8312.7" "" "" "" "" "" "" "" "" "" "" "7955.6" "6596.1" "7481.6" "6282.8" "5884.1" "6816.0" "6417.9" "6237.7" "7449.3" "8312.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5372925708799750934" "False" "High" "IsMasterProtein" "Q15046" "Lysine--tRNA ligase OS=Homo sapiens OX=9606 GN=KARS1 PE=1 SV=3" "0.000" "False" "67.484" "27" "15" "36" "15" "597" "68.0" "6.35" "98.93" "15" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336" "3735" "ENSG00000065427" "KARS1" "A8MSK1; D3DUK4; hsa:3735; O14946; Q15046; Q96J25; Q9HB23" "" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "3" "0" "1.009" "0.895" "1.066" "0.952" "1.014" "1.016" "1.012" "1.022" "1.063" "1916.8" "1933.5" "1716.2" "2043.7" "1825.7" "1943.9" "1946.9" "1940.5" "1959.8" "2037.5" "" "" "" "" "" "" "" "" "" "" "1147.1" "1004.8" "950.4" "959.5" "846.3" "995.1" "905.3" "871.2" "1063.3" "2037.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-504997331308259812" "False" "High" "IsMasterProtein" "P17174" "Aspartate aminotransferase, cytoplasmic OS=Homo sapiens OX=9606 GN=GOT1 PE=1 SV=3" "0.000" "False" "67.453" "32" "14" "50" "14" "413" "46.2" "7.01" "152.32" "14" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00155" "2805" "ENSG00000120053" "GOT1" "B2R6R7; B7Z7E9; hsa:2805; P17174; Q5VW80" "Alanine and aspartate metabolism; Trans-sulfuration pathway; Amino acid metabolism; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; TCA cycle in senescence; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Gluconeogenesis; Aspartate and asparagine metabolism; Methionine salvage pathway" "11" "0" "1.003" "1.006" "0.999" "0.973" "0.886" "1.032" "1.020" "1.028" "0.591" "4324.6" "4335.7" "4348.6" "4321.8" "4209.0" "3831.6" "4462.9" "4409.6" "4444.3" "2555.8" "" "" "" "" "" "" "" "" "" "" "2588.0" "2253.1" "2408.1" "2029.0" "1950.9" "1961.5" "2075.2" "1979.6" "2411.2" "2555.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8781846477469752128" "False" "High" "IsMasterProtein" "P38606" "V-type proton ATPase catalytic subunit A OS=Homo sapiens OX=9606 GN=ATP6V1A PE=1 SV=2" "0.000" "False" "66.679" "27" "15" "42" "15" "617" "68.3" "5.52" "125.70" "15" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00006, Pf02874, Pf16886" "523" "ENSG00000114573" "ATP6V1A" "B2RBR8; B7Z1R5; D3DN75; hsa:523; P38606; Q53YD9; Q96DY6; Q9UHY3" "Proximal tubule transport" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "6" "0" "1.016" "1.021" "1.050" "0.956" "1.075" "0.986" "1.007" "1.015" "0.977" "2888.1" "2932.9" "2948.1" "3033.2" "2762.2" "3105.3" "2848.3" "2909.2" "2930.0" "2820.4" "" "" "" "" "" "" "" "" "" "" "1728.4" "1524.1" "1632.6" "1424.0" "1280.3" "1589.7" "1324.4" "1306.1" "1589.7" "2820.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4288023909312929848" "False" "High" "IsMasterProtein" "P06744" "Glucose-6-phosphate isomerase OS=Homo sapiens OX=9606 GN=GPI PE=1 SV=4" "0.000" "False" "66.603" "28" "15" "96" "15" "558" "63.1" "8.32" "284.28" "15" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00342" "2821" "ENSG00000105220" "GPI" "B4DG39; hsa:2821; P06744; Q9BRD3; Q9BSK5; Q9UHE6" "Cori cycle; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; N-glycan biosynthesis; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts" "Glycolysis; Gluconeogenesis; Neutrophil degranulation; TP53 Regulates Metabolic Genes" "13" "0" "1.006" "0.996" "1.025" "0.946" "1.078" "0.965" "1.074" "0.991" "0.721" "7948.6" "7996.0" "7916.2" "8145.3" "7520.6" "8569.7" "7673.9" "8537.1" "7875.1" "5732.9" "" "" "" "" "" "" "" "" "" "" "4756.8" "4155.2" "4383.8" "3824.0" "3485.9" "4387.1" "3568.2" "3832.6" "4272.6" "5732.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1968544072233028588" "False" "High" "IsMasterProtein" "P23246" "Splicing factor, proline- and glutamine-rich OS=Homo sapiens OX=9606 GN=SFPQ PE=1 SV=2" "0.000" "False" "66.457" "21" "16" "40" "15" "707" "76.1" "9.44" "107.27" "16" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08075" "6421" "ENSG00000116560" "SFPQ" "hsa:6421; P23246; P30808; Q5SZ71" "mRNA processing; Type 2 papillary renal cell carcinoma" "Suppression of apoptosis; PTK6 Regulates Proteins Involved in RNA Processing" "4" "1" "0.958" "0.987" "0.975" "0.997" "1.003" "0.954" "0.504" "1.017" "6.189" "1236.8" "1184.3" "1220.3" "1205.5" "1232.8" "1240.6" "1179.9" "623.9" "1258.1" "7655.0" "" "" "" "" "" "" "" "" "" "" "740.2" "615.5" "675.8" "565.9" "571.4" "635.1" "548.6" "280.1" "682.6" "7655.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5089087001200962096" "False" "High" "IsMasterProtein" "Q12802" "A-kinase anchor protein 13 OS=Homo sapiens OX=9606 GN=AKAP13 PE=1 SV=2" "0.000" "False" "66.240" "8" "16" "21" "16" "2813" "307.4" "5.24" "60.45" "16" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621, Pf10522" "11214" "ENSG00000170776" "AKAP13" "hsa:11214; Q12802; Q14572; Q59FP6; Q86W90; Q8WXQ6; Q96JP6; Q96P79; Q9Y5T0; Q9Y5T6" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; G protein signaling pathways" "RHOC GTPase cycle; RHOA GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle" "8" "0" "1.137" "1.014" "1.206" "1.158" "1.014" "1.090" "1.045" "1.126" "1.317" "202.0" "229.6" "204.7" "243.5" "233.8" "204.9" "220.2" "211.0" "227.4" "266.0" "" "" "" "" "" "" "" "" "" "" "120.9" "119.3" "113.4" "114.3" "108.4" "104.9" "102.4" "94.7" "123.4" "266.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5241599952766811941" "False" "High" "IsMasterProtein" "P09211" "Glutathione S-transferase P OS=Homo sapiens OX=9606 GN=GSTP1 PE=1 SV=2" "0.000" "False" "66.109" "51" "9" "80" "9" "210" "23.3" "5.64" "193.92" "9" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02798, Pf14497" "2950" "ENSG00000084207" "GSTP1" "hsa:2950; O00460; P09211; Q15690; Q5TZY3" "Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Exercise-induced circadian regulation; Omega-6-fatty acids in senescence; Arachidonate epoxygenase / epoxide hydrolase; Metapathway biotransformation Phase I and II" "Neutrophil degranulation; Paracetamol ADME; Detoxification of Reactive Oxygen Species; Glutathione conjugation" "11" "0" "0.948" "0.954" "0.892" "0.816" "1.049" "0.812" "0.972" "0.954" "0.695" "5930.2" "5623.8" "5659.4" "5292.2" "4840.6" "6219.7" "4815.1" "5763.1" "5659.0" "4121.7" "" "" "" "" "" "" "" "" "" "" "3548.9" "2922.5" "3134.0" "2484.6" "2243.7" "3184.0" "2238.9" "2587.3" "3070.2" "4121.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2123612860387903516" "False" "High" "IsMasterProtein" "P08243" "Asparagine synthetase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=ASNS PE=1 SV=4" "0.000" "False" "65.796" "28" "16" "83" "16" "561" "64.3" "6.86" "192.88" "16" "other metabolic processes;stress response;other biological processes" "cytosol" "other molecular function" "Pf00733, Pf13537" "440" "ENSG00000070669" "ASNS" "A4D1I8; B4DXZ1; B7ZAA9; D6W5R3; E9PCI3; E9PCX6; hsa:440; P08184; P08243; Q15666; Q549T9; Q96HD0" "Photodynamic therapy-induced unfolded protein response; Amino acid metabolism" "Aspartate and asparagine metabolism; Response of EIF2AK1 (HRI) to heme deficiency; ATF4 activates genes in response to endoplasmic reticulum stress; Response of EIF2AK4 (GCN2) to amino acid deficiency" "6" "0" "0.957" "0.866" "1.014" "0.985" "1.032" "0.992" "1.008" "0.991" "0.644" "3154.8" "3020.3" "2731.0" "3200.0" "3106.1" "3255.2" "3128.9" "3179.0" "3127.6" "2030.4" "" "" "" "" "" "" "" "" "" "" "1888.0" "1569.5" "1512.4" "1502.3" "1439.7" "1666.4" "1454.9" "1427.2" "1696.9" "2030.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8117017983706301691" "False" "High" "IsMasterProtein" "P27348" "14-3-3 protein theta OS=Homo sapiens OX=9606 GN=YWHAQ PE=1 SV=1" "0.000" "False" "65.734" "58" "13" "129" "7" "245" "27.7" "4.78" "332.19" "13" "signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00244" "10971" "ENSG00000134308" "YWHAQ" "D6W4Z5; hsa:10971; P27348; Q567U5; Q5TZU8; Q9UP48" "Cell cycle; Pathogenic Escherichia coli infection; Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Leukocyte-intrinsic Hippo pathway functions; Hepatitis B infection; Opioid receptor pathways; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "19" "1" "1.085" "1.130" "1.054" "1.145" "1.098" "1.102" "1.009" "1.123" "1.681" "1120.4" "1215.8" "1266.4" "1181.0" "1283.0" "1230.3" "1234.3" "1130.8" "1258.2" "1883.0" "" "" "" "" "" "" "" "" "" "" "670.5" "631.8" "701.3" "554.4" "594.7" "629.8" "573.9" "507.7" "682.6" "1883.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6804108956499343623" "False" "High" "IsMasterProtein" "Q96G03" "Phosphopentomutase OS=Homo sapiens OX=9606 GN=PGM2 PE=1 SV=4" "0.000" "False" "65.634" "23" "15" "29" "15" "612" "68.2" "6.73" "89.87" "15" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf02878, Pf02879, Pf02880" "55276" "ENSG00000169299" "PGM2" "B4E0G8; hsa:55276; Q53FP5; Q5QTR0; Q96G03; Q9H0P9; Q9NV22" "Clear cell renal cell carcinoma pathways; Glucuronidation" "Neutrophil degranulation; Pentose phosphate pathway" "4" "0" "1.055" "0.995" "1.054" "1.013" "1.041" "0.952" "1.092" "1.015" "0.578" "2976.3" "3139.5" "2961.2" "3138.1" "3013.8" "3098.7" "2832.1" "3249.6" "3019.9" "1721.1" "" "" "" "" "" "" "" "" "" "" "1781.1" "1631.5" "1639.8" "1473.3" "1396.9" "1586.3" "1316.9" "1458.9" "1638.4" "1721.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1853475733980272119" "False" "High" "IsMasterProtein" "P17858" "ATP-dependent 6-phosphofructokinase, liver type OS=Homo sapiens OX=9606 GN=PFKL PE=1 SV=6" "0.000" "False" "65.623" "22" "14" "56" "9" "780" "85.0" "7.50" "157.35" "14" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "kinase activity;other molecular function" "Pf00365" "5211" "ENSG00000141959" "PFKL" "hsa:5211; P17858; Q96A64; Q96IH4; Q9BR91" "Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Insulin signaling; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Neutrophil degranulation; Glycolysis" "9" "0" "1.081" "1.000" "1.065" "1.088" "1.114" "1.172" "1.153" "0.992" "0.628" "482.2" "521.3" "482.1" "513.3" "524.8" "537.0" "565.2" "556.0" "478.5" "302.9" "" "" "" "" "" "" "" "" "" "" "288.6" "270.9" "267.0" "241.0" "243.2" "274.9" "262.8" "249.6" "259.6" "302.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-537602968940689111" "False" "High" "IsMasterProtein" "P30153" "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R1A PE=1 SV=4" "0.000" "False" "65.493" "29" "17" "45" "14" "589" "65.3" "5.11" "107.17" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02985" "5518" "ENSG00000105568" "PPP2R1A" "hsa:5518; P30153; Q13773; Q6ICQ3; Q96DH3" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF activation; Negative regulation of MAPK pathway; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; PKR-mediated signaling; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "50" "3" "1.029" "1.020" "1.054" "1.020" "1.030" "1.039" "1.011" "0.994" "0.858" "2312.3" "2378.4" "2357.8" "2438.2" "2358.0" "2382.3" "2401.6" "2337.2" "2299.0" "1984.4" "" "" "" "" "" "" "" "" "" "" "1383.8" "1236.0" "1305.7" "1144.7" "1093.0" "1219.6" "1116.7" "1049.3" "1247.3" "1984.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7523949865199722082" "False" "High" "IsMasterProtein" "P50579" "Methionine aminopeptidase 2 OS=Homo sapiens OX=9606 GN=METAP2 PE=1 SV=1" "0.000" "False" "65.166" "29" "13" "44" "13" "478" "52.9" "5.82" "119.90" "13" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00557" "10988" "ENSG00000111142" "METAP2" "B2RDI8; B4DUX5; G3XA91; hsa:10988; P50579; Q8NB11" "" "Inactivation, recovery and regulation of the phototransduction cascade" "1" "0" "1.051" "1.006" "0.968" "1.032" "0.945" "1.157" "0.999" "1.135" "0.587" "2511.3" "2638.7" "2525.2" "2432.0" "2592.6" "2372.8" "2906.1" "2509.3" "2850.5" "1475.2" "" "" "" "" "" "" "" "" "" "" "1502.9" "1371.2" "1398.4" "1141.8" "1201.7" "1214.7" "1351.3" "1126.5" "1546.5" "1475.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6490484038664760531" "False" "High" "IsMasterProtein" "Q13283" "Ras GTPase-activating protein-binding protein 1 OS=Homo sapiens OX=9606 GN=G3BP1 PE=1 SV=1" "0.000" "False" "65.049" "34" "11" "44" "11" "466" "52.1" "5.52" "107.00" "11" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00076, Pf02136" "10146" "ENSG00000145907" "G3BP1" "hsa:10146; Q13283; Q5HYE9" "7q11.23 distal copy number variation; HDAC6 interactions in the central nervous system" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "3" "0" "1.071" "1.082" "1.115" "1.097" "1.052" "1.055" "1.089" "1.099" "1.358" "1459.3" "1563.0" "1578.8" "1626.8" "1600.8" "1535.3" "1539.2" "1589.0" "1603.5" "1981.5" "" "" "" "" "" "" "" "" "" "" "873.3" "812.2" "874.3" "763.7" "742.0" "786.0" "715.7" "713.4" "870.0" "1981.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8676466481375871245" "False" "High" "IsMasterProtein" "P08133" "Annexin A6 OS=Homo sapiens OX=9606 GN=ANXA6 PE=1 SV=3" "0.000" "False" "64.993" "28" "20" "55" "20" "673" "75.8" "5.60" "117.71" "20" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00191" "309" "ENSG00000197043" "ANXA6" "B7Z8A7; D3DQH4; E9PGK1; hsa:309; P08133; Q6ZT79" "Calcium regulation in cardiac cells; Prostaglandin synthesis and regulation" "Smooth Muscle Contraction" "3" "0" "0.957" "1.108" "1.026" "1.077" "1.040" "0.951" "0.676" "1.035" "4.783" "1033.5" "988.8" "1144.8" "1060.6" "1113.4" "1075.0" "982.4" "698.6" "1069.6" "4943.1" "" "" "" "" "" "" "" "" "" "" "618.5" "513.9" "634.0" "497.9" "516.1" "550.3" "456.8" "313.6" "580.3" "4943.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "627927697280554035" "False" "High" "IsMasterProtein" "O60841" "Eukaryotic translation initiation factor 5B OS=Homo sapiens OX=9606 GN=EIF5B PE=1 SV=4" "0.000" "False" "64.810" "14" "16" "23" "16" "1220" "138.7" "5.49" "68.96" "16" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf11987, Pf14578" "9669" "ENSG00000158417" "EIF5B" "hsa:9669; O60841; O95805; Q53RV7; Q53SI8; Q9UF81; Q9UMN7" "Translation factors; Ciliary landscape" "GTP hydrolysis and joining of the 60S ribosomal subunit" "3" "0" "1.004" "0.995" "1.016" "0.991" "1.014" "1.041" "0.955" "0.973" "1.800" "1686.7" "1692.9" "1678.0" "1713.4" "1672.4" "1709.8" "1755.5" "1610.3" "1641.4" "3036.1" "" "" "" "" "" "" "" "" "" "" "1009.4" "879.7" "929.3" "804.4" "775.2" "875.3" "816.3" "722.9" "890.5" "3036.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5870318523395655526" "False" "High" "IsMasterProtein" "P49591" "Serine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=SARS1 PE=1 SV=3" "0.000" "False" "64.695" "31" "15" "49" "15" "514" "58.7" "6.43" "128.19" "15" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00587, Pf02403" "6301" "ENSG00000031698" "SARS1" "B2R6Y9; hsa:6301; P49591; Q5T5C8; Q9NSE3" "VEGFA-VEGFR2 signaling" "Cytosolic tRNA aminoacylation; Selenocysteine synthesis" "3" "0" "1.030" "0.979" "1.075" "1.031" "1.025" "1.023" "0.989" "1.017" "0.914" "2945.9" "3035.1" "2885.3" "3167.0" "3037.7" "3019.1" "3013.8" "2913.7" "2995.8" "2693.6" "" "" "" "" "" "" "" "" "" "" "1763.0" "1577.2" "1597.8" "1486.8" "1408.0" "1545.5" "1401.4" "1308.1" "1625.4" "2693.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1936662048644361405" "False" "High" "IsMasterProtein" "P55060" "Exportin-2 OS=Homo sapiens OX=9606 GN=CSE1L PE=1 SV=3" "0.000" "False" "64.494" "17" "16" "31" "16" "971" "110.3" "5.77" "74.67" "16" "transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf03378, Pf03810, Pf08506" "1434" "ENSG00000124207" "CSE1L" "A3RLL6; B2R5T4; E1P5Y0; F8W904; hsa:1434; O75432; P55060; Q32M40; Q9H5B7; Q9NTS0; Q9UP98; Q9UP99; Q9UPA0" "" "" "0" "0" "1.034" "1.167" "1.175" "1.179" "1.137" "1.088" "0.584" "1.052" "7.058" "652.7" "674.8" "761.7" "767.1" "769.3" "742.4" "710.1" "381.1" "686.9" "4606.7" "" "" "" "" "" "" "" "" "" "" "390.6" "350.6" "421.8" "360.1" "356.6" "380.1" "330.2" "171.1" "372.7" "4606.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-16918109513615625" "False" "High" "IsMasterProtein" "P51149" "Ras-related protein Rab-7a OS=Homo sapiens OX=9606 GN=RAB7A PE=1 SV=1" "0.000" "False" "64.471" "57" "11" "39" "11" "207" "23.5" "6.70" "108.50" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "7879" "ENSG00000075785" "RAB7A" "A8K3V6; hsa:7879; P51149; Q9NWJ0; Q9UPB0" "Ebola virus infection in host; Autosomal recessive osteopetrosis pathways; Intracellular trafficking proteins involved in CMT neuropathy" "RHOG GTPase cycle; TBC/RABGAPs; Neutrophil degranulation; Prevention of phagosomal-lysosomal fusion; RAB geranylgeranylation; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAB GEFs exchange GTP for GDP on RABs; MHC class II antigen presentation; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Suppression of autophagy; RHOH GTPase cycle" "20" "0" "0.918" "0.931" "0.900" "0.991" "0.978" "0.961" "0.951" "0.997" "0.546" "2128.9" "1955.2" "1982.3" "1915.7" "2110.7" "2081.4" "2045.3" "2024.2" "2123.1" "1162.5" "" "" "" "" "" "" "" "" "" "" "1274.0" "1016.1" "1097.8" "899.4" "978.4" "1065.5" "951.0" "908.7" "1151.9" "1162.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1538896593466497334" "False" "High" "IsMasterProtein" "P23528" "Cofilin-1 OS=Homo sapiens OX=9606 GN=CFL1 PE=1 SV=3" "0.000" "False" "64.313" "66" "11" "110" "8" "166" "18.5" "8.09" "243.66" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00241" "1072" "ENSG00000172757" "CFL1" "B3KUQ1; hsa:1072; P23528; Q53Y87; Q9UCA2" "Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; 7q11.23 copy number variation syndrome; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "Platelet degranulation ; Regulation of actin dynamics for phagocytic cup formation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; EPHB-mediated forward signaling; Sema3A PAK dependent Axon repulsion; RHO GTPases Activate ROCKs" "15" "2" "0.982" "1.003" "0.923" "0.951" "0.948" "0.905" "0.978" "0.908" "0.749" "6824.1" "6698.3" "6841.9" "6298.8" "6491.5" "6470.5" "6176.4" "6674.5" "6195.2" "5110.8" "" "" "" "" "" "" "" "" "" "" "4083.9" "3480.9" "3788.9" "2957.1" "3008.9" "3312.4" "2871.9" "2996.5" "3361.2" "5110.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6707926075363841764" "False" "High" "IsMasterProtein" "Q99798" "Aconitate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ACO2 PE=1 SV=2" "0.000" "False" "63.872" "20" "14" "34" "14" "780" "85.4" "7.61" "81.77" "14" "other metabolic processes;stress response;developmental processes" "cytosol;mitochondrion" "other molecular function" "Pf00330, Pf00694" "50" "ENSG00000100412" "ACO2" "hsa:50; O75809; Q5JZ41; Q6FHX0; Q8TAQ6; Q99798" "Amino acid metabolism; Metabolic reprogramming in colon cancer; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein import; Mitochondrial protein degradation" "7" "0" "1.027" "1.033" "1.046" "1.051" "1.039" "0.926" "0.643" "1.013" "3.698" "642.8" "660.2" "664.2" "672.4" "675.3" "668.1" "595.3" "413.5" "651.1" "2377.3" "" "" "" "" "" "" "" "" "" "" "384.7" "343.1" "367.8" "315.7" "313.0" "342.0" "276.8" "185.6" "353.3" "2377.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1074215629290594570" "False" "High" "IsMasterProtein" "P22626" "Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Homo sapiens OX=9606 GN=HNRNPA2B1 PE=1 SV=2" "0.000" "False" "63.828" "45" "14" "114" "12" "353" "37.4" "8.95" "260.91" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11627" "3181" "ENSG00000122566" "HNRNPA2B1" "A0A024RA27; A0A024RA61; A8K064; hsa:3181; P22626; P22627; Q9UC98; Q9UDJ2" "mRNA processing" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "4" "0" "1.000" "1.188" "1.072" "1.100" "1.044" "1.006" "0.935" "1.058" "2.374" "2723.5" "2722.8" "3235.9" "2918.3" "2995.3" "2842.6" "2739.7" "2546.6" "2881.1" "6465.8" "" "" "" "" "" "" "" "" "" "" "1629.9" "1414.9" "1792.0" "1370.1" "1388.4" "1455.2" "1273.9" "1143.3" "1563.1" "6465.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7129667850847229200" "False" "High" "IsMasterProtein" "P52209" "6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens OX=9606 GN=PGD PE=1 SV=3" "0.000" "False" "63.386" "30" "15" "72" "15" "483" "53.1" "7.23" "207.69" "15" "other metabolic processes" "cytosol" "other molecular function" "Pf00393, Pf03446" "5226" "ENSG00000142657" "PGD" "A8K2Y9; B4DQJ8; hsa:5226; P52209; Q9BWD8" "Pentose phosphate metabolism; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer" "NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway" "7" "0" "1.003" "0.972" "1.063" "0.981" "1.014" "1.045" "1.077" "1.022" "0.650" "3880.5" "3891.2" "3771.7" "4126.9" "3805.0" "3936.2" "4055.1" "4179.5" "3967.2" "2520.7" "" "" "" "" "" "" "" "" "" "" "2322.3" "2022.1" "2088.7" "1937.5" "1763.7" "2015.0" "1885.5" "1876.3" "2152.4" "2520.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1728322554936911435" "False" "High" "IsMasterProtein" "Q14978" "Nucleolar and coiled-body phosphoprotein 1 OS=Homo sapiens OX=9606 GN=NOLC1 PE=1 SV=2" "0.000" "False" "63.361" "27" "16" "26" "16" "699" "73.6" "9.47" "71.30" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05022" "9221" "ENSG00000166197" "NOLC1" "hsa:9221; Q14978; Q15030; Q5VV70; Q9BUV3" "" "" "0" "0" "0.912" "0.836" "0.827" "0.913" "0.873" "0.879" "0.807" "0.875" "0.468" "1698.0" "1548.4" "1419.8" "1405.0" "1550.3" "1482.3" "1491.7" "1369.5" "1485.6" "794.4" "" "" "" "" "" "" "" "" "" "" "1016.2" "804.7" "786.2" "659.6" "718.6" "758.8" "693.6" "614.8" "806.0" "794.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1828229649447777005" "False" "High" "IsMasterProtein" "P31153" "S-adenosylmethionine synthase isoform type-2 OS=Homo sapiens OX=9606 GN=MAT2A PE=1 SV=1" "0.000" "False" "63.271" "36" "13" "61" "13" "395" "43.6" "6.48" "170.27" "13" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00438, Pf02772, Pf02773" "4144" "ENSG00000168906" "MAT2A" "A8K511; B4DN45; D6W5L1; hsa:4144; P31153; Q53SP5" "Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Methylation pathways" "Methylation" "5" "0" "0.977" "0.949" "1.010" "0.930" "0.986" "1.019" "0.959" "0.948" "0.589" "3975.7" "3884.6" "3773.2" "4016.2" "3696.5" "3920.8" "4049.9" "3812.1" "3767.1" "2341.4" "" "" "" "" "" "" "" "" "" "" "2379.2" "2018.7" "2089.5" "1885.5" "1713.4" "2007.2" "1883.1" "1711.4" "2043.8" "2341.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "250780751349012114" "False" "High" "IsMasterProtein" "Cont_Q29443" "Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1" "0.000" "True" "63.102" "23" "15" "28" "15" "704" "77.7" "7.08" "78.30" "15" "stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf00405" "280705" "" "TF" "bta:280705; Q0IIK2; Q29443" "" "" "0" "0" "1.139" "1.096" "1.020" "0.815" "0.930" "1.143" "1.029" "1.206" "0.675" "1815.4" "2067.5" "1989.6" "1852.4" "1478.7" "1689.1" "2075.9" "1867.7" "2190.1" "1225.0" "" "" "" "" "" "" "" "" "" "" "1086.4" "1074.4" "1101.8" "869.6" "685.4" "864.7" "965.2" "838.5" "1188.2" "1225.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3038689840563559267" "False" "High" "IsMasterProtein" "Q8WWM7" "Ataxin-2-like protein OS=Homo sapiens OX=9606 GN=ATXN2L PE=1 SV=2" "0.000" "False" "62.846" "16" "18" "24" "17" "1075" "113.3" "8.59" "69.06" "18" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf06741, Pf07145, Pf14438" "11273" "ENSG00000168488" "ATXN2L" "A8K1R6; B9EGM2; E9PAR9; hsa:11273; O95135; Q63ZY4; Q6NVJ8; Q6PJW6; Q8IU61; Q8IU95; Q8WWM3; Q8WWM4; Q8WWM5; Q8WWM6; Q8WWM7; Q99703" "16p11.2 distal deletion syndrome" "" "1" "1" "1.064" "1.103" "1.083" "1.124" "1.114" "1.044" "1.099" "1.095" "1.112" "1529.6" "1628.1" "1687.4" "1656.4" "1719.3" "1704.1" "1597.4" "1680.8" "1674.2" "1701.1" "" "" "" "" "" "" "" "" "" "" "915.4" "846.1" "934.4" "777.6" "796.9" "872.4" "742.7" "754.6" "908.3" "1701.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2320605404870657198" "False" "High" "IsMasterProtein" "Q8NC51" "SERPINE1 mRNA-binding protein 1 OS=Homo sapiens OX=9606 GN=SERBP1 PE=1 SV=2" "0.000" "False" "62.825" "33" "12" "33" "12" "408" "44.9" "8.65" "79.08" "12" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04774, Pf16174" "26135" "ENSG00000142864" "SERBP1" "hsa:26135; Q5VU19; Q5VU20; Q5VU22; Q8NC51; Q8WUH0; Q96SE2; Q9BTY3; Q9BUM4; Q9Y367; Q9Y4S3" "Apoptosis-related network due to altered Notch3 in ovarian cancer" "" "1" "0" "0.809" "0.984" "0.811" "0.908" "0.986" "0.826" "0.891" "0.998" "0.294" "1308.2" "1058.1" "1287.5" "1061.5" "1188.4" "1290.3" "1080.0" "1165.3" "1306.1" "385.1" "" "" "" "" "" "" "" "" "" "" "782.9" "549.9" "713.0" "498.3" "550.8" "660.5" "502.2" "523.2" "708.6" "385.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8320203953169685442" "False" "High" "IsMasterProtein" "Q9NZL9" "Methionine adenosyltransferase 2 subunit beta OS=Homo sapiens OX=9606 GN=MAT2B PE=1 SV=1" "0.000" "False" "62.726" "40" "12" "42" "12" "334" "37.5" "7.36" "115.33" "12" "other metabolic processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04321" "27430" "ENSG00000038274" "MAT2B" "B2R5Y6; hsa:27430; Q1WAI7; Q27J92; Q3LIE8; Q567T7; Q6NYC7; Q9BS89; Q9H3E1; Q9NZL9; Q9UJ54" "Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; Spina bifida; Methylation pathways" "Ub-specific processing proteases; Methylation" "8" "0" "1.000" "0.999" "1.067" "0.972" "1.010" "0.968" "1.040" "0.941" "0.533" "1640.9" "1640.6" "1639.8" "1750.4" "1594.4" "1657.6" "1587.8" "1705.9" "1543.9" "874.5" "" "" "" "" "" "" "" "" "" "" "982.0" "852.5" "908.1" "821.8" "739.0" "848.6" "738.3" "765.9" "837.6" "874.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2411801021050745689" "False" "High" "IsMasterProtein" "Q9NSE4" "Isoleucine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=IARS2 PE=1 SV=2" "0.000" "False" "62.703" "16" "14" "28" "14" "1012" "113.7" "7.20" "78.03" "14" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00133, Pf06827, Pf08264" "55699" "ENSG00000067704" "IARS2" "B2RPG8; hsa:55699; Q1M2P9; Q6PI85; Q7L439; Q86WU9; Q96D91; Q9H9Q8; Q9NSE4; Q9NW42" "" "Mitochondrial protein degradation; Mitochondrial tRNA aminoacylation" "2" "0" "1.052" "0.956" "1.031" "0.970" "1.010" "0.933" "0.967" "0.905" "0.731" "1125.1" "1183.2" "1075.9" "1160.4" "1091.2" "1136.0" "1049.9" "1087.6" "1018.2" "822.0" "" "" "" "" "" "" "" "" "" "" "673.3" "614.9" "595.8" "544.8" "505.8" "581.5" "488.2" "488.3" "552.4" "822.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5486623488286150829" "False" "High" "IsMasterProtein" "Q9UBT2" "SUMO-activating enzyme subunit 2 OS=Homo sapiens OX=9606 GN=UBA2 PE=1 SV=2" "0.000" "False" "62.472" "23" "13" "37" "13" "640" "71.2" "5.29" "86.95" "13" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00899, Pf14732, Pf16195" "10054" "ENSG00000126261" "UBA2" "B3KWB9; hsa:10054; O95605; Q59H87; Q6IBP6; Q9NTJ1; Q9UBT2; Q9UED2" "" "SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "2" "0" "1.101" "1.211" "1.006" "1.104" "1.122" "1.008" "0.983" "1.056" "1.578" "665.1" "732.3" "805.5" "669.2" "734.1" "746.0" "670.4" "654.0" "702.2" "1049.8" "" "" "" "" "" "" "" "" "" "" "398.0" "380.6" "446.1" "314.2" "340.3" "381.9" "311.7" "293.6" "381.0" "1049.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1669243048092869257" "False" "High" "IsMasterProtein" "Q8WU90" "Zinc finger CCCH domain-containing protein 15 OS=Homo sapiens OX=9606 GN=ZC3H15 PE=1 SV=1" "0.000" "False" "62.448" "37" "17" "30" "17" "426" "48.6" "5.31" "77.03" "17" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00642, Pf16543" "55854" "ENSG00000065548" "ZC3H15" "B4DMW2; D3DPG7; hsa:55854; Q5QTQ4; Q8WU90; Q8WZ06; Q9NUZ3; Q9NZ37; Q9P079" "VEGFA-VEGFR2 signaling" "Protein hydroxylation" "2" "0" "1.063" "0.971" "0.975" "1.075" "1.016" "1.045" "1.111" "1.015" "0.639" "2515.4" "2673.2" "2443.0" "2453.6" "2703.3" "2554.8" "2628.7" "2794.6" "2553.8" "1607.4" "" "" "" "" "" "" "" "" "" "" "1505.4" "1389.2" "1352.9" "1151.9" "1253.0" "1307.8" "1222.3" "1254.6" "1385.6" "1607.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3211102690049465357" "False" "High" "IsMasterProtein" "P11310" "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADM PE=1 SV=1" "0.000" "False" "62.360" "26" "11" "73" "11" "421" "46.6" "8.37" "250.85" "11" "other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00441, Pf02770, Pf02771" "34" "ENSG00000117054" "ACADM" "hsa:34; P11310; Q5T4U4; Q9NYF1" "Fatty acid beta-oxidation; PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; Amino acid metabolism; PPAR signaling pathway; Mitochondrial fatty acid oxidation disorders; Female steroid hormones in cardiomyocyte energy metabolism; Sudden infant death syndrome (SIDS) susceptibility pathways" "PPARA activates gene expression; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA" "13" "0" "0.957" "0.924" "0.939" "0.934" "0.951" "0.927" "0.975" "0.974" "0.668" "5068.4" "4851.2" "4685.1" "4758.1" "4733.6" "4821.6" "4699.2" "4941.6" "4938.9" "3384.5" "" "" "" "" "" "" "" "" "" "" "3033.2" "2521.0" "2594.5" "2233.8" "2194.1" "2468.3" "2185.0" "2218.5" "2679.6" "3384.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5340528139668487905" "False" "High" "IsMasterProtein" "O95831" "Apoptosis-inducing factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=AIFM1 PE=1 SV=1" "0.000" "False" "62.320" "23" "12" "33" "12" "613" "66.9" "8.95" "90.87" "12" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00070, Pf14721" "9131" "ENSG00000156709" "AIFM1" "A4QPB4; B1ALN1; B2RB08; D3DTE9; E9PRR0; O95831; Q1L6K4; Q1L6K6; Q2QKE4; Q5JUZ7; Q6I9X6; Q9Y3I3; Q9Y3I4" "Apoptosis modulation and signaling; Nanomaterial induced apoptosis; Apoptosis modulation by HSP70" "" "3" "0" "0.989" "0.906" "0.933" "1.026" "0.944" "1.014" "0.997" "1.005" "0.416" "1841.9" "1822.2" "1668.5" "1718.5" "1889.5" "1738.7" "1867.4" "1836.5" "1851.4" "767.0" "" "" "" "" "" "" "" "" "" "" "1102.3" "946.9" "924.0" "806.8" "875.8" "890.1" "868.3" "824.5" "1004.5" "767.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2468696703933973892" "False" "High" "IsMasterProtein" "P23921" "Ribonucleoside-diphosphate reductase large subunit OS=Homo sapiens OX=9606 GN=RRM1 PE=1 SV=1" "0.000" "False" "62.270" "19" "16" "45" "16" "792" "90.0" "7.15" "115.06" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00317, Pf02867, Pf03477" "6240" "ENSG00000167325" "RRM1" "hsa:6240; P23921; Q9UNN2" "Fluoropyrimidine activity; Retinoblastoma gene in cancer; Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "4" "0" "1.001" "0.947" "1.017" "1.007" "1.066" "1.162" "1.346" "1.273" "0.863" "3775.0" "3777.9" "3573.4" "3839.9" "3803.0" "4023.0" "4387.7" "5080.7" "4804.9" "3257.6" "" "" "" "" "" "" "" "" "" "" "2259.1" "1963.3" "1978.9" "1802.7" "1762.8" "2059.5" "2040.2" "2280.9" "2606.9" "3257.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4058456233631452436" "False" "High" "IsMasterProtein" "Q06830" "Peroxiredoxin-1 OS=Homo sapiens OX=9606 GN=PRDX1 PE=1 SV=1" "0.000" "False" "62.251" "43" "10" "146" "6" "199" "22.1" "8.13" "409.44" "10" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00578, Pf10417" "5052" "ENSG00000117450" "PRDX1" "B5BU26; D3DPZ8; hsa:5052; P35703; Q06830; Q2V576; Q5T154; Q5T155" "Androgen receptor signaling pathway; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway; HDAC6 interactions in the central nervous system" "Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes; NFE2L2 regulating anti-oxidant/detoxification enzymes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "9" "1" "0.986" "1.022" "0.967" "0.944" "1.000" "0.960" "0.982" "0.982" "0.782" "7454.7" "7352.9" "7616.8" "7210.5" "7037.6" "7458.2" "7156.6" "7319.1" "7321.0" "5832.7" "" "" "" "" "" "" "" "" "" "" "4461.2" "3821.0" "4218.0" "3385.1" "3262.1" "3818.1" "3327.7" "3285.8" "3972.0" "5832.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5468069501493151827" "False" "High" "IsMasterProtein" "P37837" "Transaldolase OS=Homo sapiens OX=9606 GN=TALDO1 PE=1 SV=2" "0.000" "False" "62.055" "39" "13" "46" "13" "337" "37.5" "6.81" "112.90" "13" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00923" "6888" "ENSG00000177156" "TALDO1" "B2R8M2; hsa:6888; O00751; P37837; Q8WV32; Q8WZ45" "Pentose phosphate metabolism; Cori cycle; Metabolic reprogramming in colon cancer" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate; TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P; TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P" "9" "0" "1.031" "1.040" "1.079" "0.992" "1.017" "0.949" "0.888" "0.938" "1.508" "3175.1" "3274.7" "3300.5" "3424.9" "3149.2" "3228.5" "3013.7" "2818.1" "2978.7" "4788.7" "" "" "" "" "" "" "" "" "" "" "1900.1" "1701.7" "1827.8" "1607.9" "1459.7" "1652.8" "1401.3" "1265.2" "1616.1" "4788.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951923410761951319" "False" "High" "IsMasterProtein" "Q9UQ80" "Proliferation-associated protein 2G4 OS=Homo sapiens OX=9606 GN=PA2G4 PE=1 SV=3" "0.000" "False" "61.697" "38" "13" "51" "13" "394" "43.8" "6.55" "122.96" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00557" "5036" "ENSG00000170515" "PA2G4" "hsa:5036; O43846; Q9UM59; Q9UQ80" "" "Neutrophil degranulation" "1" "0" "1.085" "1.015" "1.126" "1.048" "1.022" "1.106" "1.008" "1.082" "2.054" "2736.4" "2969.3" "2778.4" "3080.0" "2867.5" "2795.3" "3027.6" "2757.0" "2962.0" "5619.5" "" "" "" "" "" "" "" "" "" "" "1637.6" "1543.0" "1538.6" "1446.0" "1329.1" "1431.0" "1407.8" "1237.7" "1607.0" "5619.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6973365880698085835" "False" "High" "IsMasterProtein" "Q9UHD8" "Septin-9 OS=Homo sapiens OX=9606 GN=SEPTIN9 PE=1 SV=2" "0.000" "False" "61.472" "27" "16" "46" "16" "586" "65.4" "8.97" "100.07" "16" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00735" "10801" "ENSG00000184640" "SEPTIN9" "A8K2V3; B3KPM0; B4DTL9; B4E0N2; B4E274; B7Z654; hsa:10801; Q96QF3; Q96QF4; Q96QF5; Q9HA04; Q9UG40; Q9UHD8; Q9Y5W4" "" "" "0" "0" "1.019" "0.933" "1.066" "1.049" "1.013" "1.015" "1.104" "1.018" "0.853" "1080.2" "1100.6" "1008.3" "1151.7" "1133.3" "1094.2" "1095.9" "1192.1" "1099.2" "921.3" "" "" "" "" "" "" "" "" "" "" "646.4" "571.9" "558.4" "540.7" "525.3" "560.2" "509.6" "535.2" "596.4" "921.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8900163226744829744" "False" "High" "IsMasterProtein" "Q99590" "Protein SCAF11 OS=Homo sapiens OX=9606 GN=SCAF11 PE=1 SV=2" "0.000" "False" "61.332" "10" "13" "16" "13" "1463" "164.6" "8.41" "54.49" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf13639" "9169" "ENSG00000139218" "SCAF11" "A6NEU9; A6NLW5; hsa:9169; Q8IW59; Q99590" "Apoptosis" "" "1" "0" "1.054" "0.946" "0.982" "0.984" "0.959" "1.051" "1.089" "0.984" "0.612" "793.0" "835.9" "750.2" "778.9" "780.4" "760.1" "833.3" "863.4" "780.6" "485.6" "" "" "" "" "" "" "" "" "" "" "474.6" "434.4" "415.4" "365.7" "361.7" "389.1" "387.5" "387.6" "423.5" "485.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9125415552757105331" "False" "High" "IsMasterProtein" "Q05639" "Elongation factor 1-alpha 2 OS=Homo sapiens OX=9606 GN=EEF1A2 PE=1 SV=1" "0.000" "False" "61.146" "21" "10" "148" "3" "463" "50.4" "9.03" "431.36" "10" "protein metabolism;other metabolic processes;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "1917" "ENSG00000101210" "EEF1A2" "B5BUF3; E1P5J1; hsa:1917; P54266; Q05639; Q0VGC7" "Translation factors" "Eukaryotic Translation Elongation" "2" "0" "0.953" "0.896" "1.002" "0.906" "0.971" "0.828" "0.896" "0.911" "0.710" "911.7" "868.6" "817.1" "913.5" "826.0" "884.8" "755.1" "817.1" "830.8" "647.7" "" "" "" "" "" "" "" "" "" "" "545.6" "451.4" "452.5" "428.9" "382.9" "452.9" "351.1" "366.8" "450.7" "647.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4347150339173577721" "False" "High" "IsMasterProtein" "Q92878" "DNA repair protein RAD50 OS=Homo sapiens OX=9606 GN=RAD50 PE=1 SV=1" "0.000" "False" "61.098" "13" "19" "22" "19" "1312" "153.8" "6.89" "58.94" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04423, Pf13476, Pf13558" "10111" "ENSG00000113522" "RAD50" "B9EGF5; hsa:10111; O43254; Q6GMT7; Q6P5X3; Q92878; Q9UP86" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; Joubert syndrome; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; DNA damage response" "Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks" "29" "0" "1.076" "1.081" "1.100" "1.186" "1.091" "0.953" "0.697" "0.988" "3.617" "1016.6" "1093.5" "1098.6" "1118.5" "1206.0" "1109.3" "968.8" "708.4" "1004.4" "3676.7" "" "" "" "" "" "" "" "" "" "" "608.4" "568.3" "608.4" "525.1" "559.0" "567.9" "450.5" "318.1" "544.9" "3676.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7054273267636823051" "False" "High" "IsMasterProtein" "Q08211" "ATP-dependent RNA helicase A OS=Homo sapiens OX=9606 GN=DHX9 PE=1 SV=4" "0.000" "False" "61.034" "13" "14" "25" "14" "1270" "140.9" "6.84" "71.77" "14" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00035, Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "1660" "ENSG00000135829" "DHX9" "B2RNV4; hsa:1660; Q05CI5; Q08211; Q12803; Q32Q22; Q5VY62; Q6PD69; Q99556" "MECP2 and associated Rett syndrome; mRNA processing" "mRNA Splicing - Major Pathway; PKR-mediated signaling; RIP-mediated NFkB activation via ZBP1; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "6" "0" "1.048" "1.069" "1.126" "1.168" "1.081" "1.065" "0.603" "1.143" "5.289" "533.1" "558.7" "570.1" "600.2" "622.6" "576.3" "567.7" "321.2" "609.4" "2819.5" "" "" "" "" "" "" "" "" "" "" "319.0" "290.3" "315.7" "281.8" "288.6" "295.0" "264.0" "144.2" "330.6" "2819.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5864065326781896084" "False" "High" "IsMasterProtein" "P27708" "Multifunctional protein CAD OS=Homo sapiens OX=9606 GN=CAD PE=1 SV=3" "0.000" "False" "60.796" "9" "21" "27" "21" "2225" "242.8" "6.46" "57.37" "21" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00117, Pf00185, Pf00988, Pf01979, Pf02142, Pf02729, Pf02786, Pf02787" "790" "ENSG00000084774" "CAD" "D6W552; hsa:790; P27708; Q6P0Q0; Q96CK3" "Endothelin pathways; Amino acid metabolism; Pyrimidine metabolism" "Pyrimidine biosynthesis" "4" "0" "1.051" "1.077" "1.232" "1.180" "1.134" "1.233" "0.659" "1.077" "6.471" "799.2" "840.2" "860.9" "984.6" "943.1" "906.4" "985.4" "526.7" "860.5" "5171.9" "" "" "" "" "" "" "" "" "" "" "478.3" "436.6" "476.8" "462.2" "437.2" "464.0" "458.2" "236.5" "466.9" "5171.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4532618803689773049" "False" "High" "IsMasterProtein" "P00491" "Purine nucleoside phosphorylase OS=Homo sapiens OX=9606 GN=PNP PE=1 SV=2" "0.000" "False" "60.696" "63" "14" "38" "14" "289" "32.1" "6.95" "95.52" "14" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf01048" "4860" "ENSG00000198805; ENSG00000291814" "PNP" "B2R8S5; D3DS00; hsa:4860; P00491; Q15160; Q5PZ03" "VEGFA-VEGFR2 signaling" "Neutrophil degranulation; Purine catabolism; Ribavirin ADME; Purine salvage; Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine" "6" "0" "0.978" "0.934" "0.976" "0.934" "1.058" "0.972" "0.985" "0.973" "0.713" "2032.2" "1986.6" "1897.4" "1983.6" "1898.2" "2150.2" "1975.4" "2001.2" "1976.9" "1448.0" "" "" "" "" "" "" "" "" "" "" "1216.2" "1032.4" "1050.8" "931.2" "879.9" "1100.7" "918.5" "898.4" "1072.6" "1448.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4773459124454051332" "False" "High" "IsMasterProtein" "P49915" "GMP synthase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=GMPS PE=1 SV=1" "0.000" "False" "60.631" "26" "17" "35" "17" "693" "76.7" "6.87" "87.30" "17" "other metabolic processes" "cytosol" "other molecular function" "Pf00117, Pf00958, Pf02540" "8833" "ENSG00000163655" "GMPS" "A8K639; B4DXV7; F8W720; hsa:8833; P49915" "" "Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "2" "0" "1.122" "1.016" "1.101" "1.160" "1.178" "1.176" "0.954" "1.133" "3.863" "926.5" "1039.2" "941.3" "1019.8" "1074.5" "1091.5" "1089.4" "883.5" "1049.4" "3579.0" "" "" "" "" "" "" "" "" "" "" "554.5" "540.0" "521.3" "478.8" "498.0" "558.7" "506.6" "396.7" "569.4" "3579.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6546682892855641805" "False" "High" "IsMasterProtein" "P12268" "Inosine-5'-monophosphate dehydrogenase 2 OS=Homo sapiens OX=9606 GN=IMPDH2 PE=1 SV=2" "0.000" "False" "60.608" "32" "14" "51" "12" "514" "55.8" "6.90" "143.34" "14" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00478, Pf00571" "3615" "ENSG00000178035" "IMPDH2" "hsa:3615; P12268; Q6LEF3" "Rett syndrome" "Neutrophil degranulation; Potential therapeutics for SARS; Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "5" "2" "1.005" "0.945" "1.059" "1.039" "1.059" "1.048" "1.078" "0.991" "0.624" "3247.2" "3262.2" "3069.1" "3439.5" "3372.2" "3438.6" "3402.2" "3500.7" "3219.3" "2024.8" "" "" "" "" "" "" "" "" "" "" "1943.3" "1695.3" "1699.6" "1614.7" "1563.1" "1760.3" "1582.0" "1571.6" "1746.6" "2024.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4010508153477037857" "False" "High" "IsMasterProtein" "Q14103" "Heterogeneous nuclear ribonucleoprotein D0 OS=Homo sapiens OX=9606 GN=HNRNPD PE=1 SV=1" "0.000" "False" "60.354" "32" "11" "60" "10" "355" "38.4" "7.81" "161.10" "11" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08143" "3184" "ENSG00000138668" "HNRNPD" "A8K9J2; hsa:3184; P07029; Q01858; Q14100; Q14101; Q14102; Q14103; Q4W5A1; Q9UCE8; Q9UCE9" "mRNA processing" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "3" "1" "0.986" "0.976" "1.032" "1.101" "1.059" "1.070" "1.142" "0.985" "0.608" "3780.3" "3727.6" "3688.1" "3902.2" "4163.1" "4003.7" "4044.9" "4317.4" "3723.8" "2300.0" "" "" "" "" "" "" "" "" "" "" "2262.3" "1937.1" "2042.4" "1832.0" "1929.7" "2049.6" "1880.8" "1938.3" "2020.3" "2300.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5986296192720168781" "False" "High" "IsMasterProtein" "Q9Y617" "Phosphoserine aminotransferase OS=Homo sapiens OX=9606 GN=PSAT1 PE=1 SV=2" "0.000" "False" "60.094" "31" "11" "40" "11" "370" "40.4" "7.66" "109.68" "11" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00266" "29968" "ENSG00000135069" "PSAT1" "hsa:29968; Q5T7G5; Q5T7G6; Q96AW2; Q9BQ12; Q9Y617" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Male infertility; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "Serine biosynthesis" "7" "0" "0.994" "0.961" "0.989" "0.941" "1.033" "0.946" "1.051" "0.963" "0.608" "2619.8" "2603.5" "2517.2" "2590.3" "2464.6" "2705.3" "2478.6" "2754.1" "2523.5" "1592.1" "" "" "" "" "" "" "" "" "" "" "1567.8" "1353.0" "1394.0" "1216.1" "1142.4" "1384.9" "1152.5" "1236.4" "1369.1" "1592.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8428260618384848940" "False" "High" "IsMasterProtein" "Q15029" "116 kDa U5 small nuclear ribonucleoprotein component OS=Homo sapiens OX=9606 GN=EFTUD2 PE=1 SV=1" "0.000" "False" "59.950" "18" "18" "46" "17" "972" "109.4" "5.00" "133.43" "18" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492, Pf16004" "9343" "ENSG00000108883" "EFTUD2" "B4DK30; B4DMC0; D3DX58; hsa:9343; K7EJ81; Q15029; Q9BUR0" "mRNA processing; Ciliary landscape" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "4" "0" "0.990" "0.900" "0.955" "0.922" "0.910" "0.971" "0.979" "0.851" "0.401" "1866.2" "1848.1" "1679.0" "1782.6" "1719.9" "1698.5" "1811.8" "1826.4" "1588.3" "747.8" "" "" "" "" "" "" "" "" "" "" "1116.8" "960.4" "929.8" "836.9" "797.2" "869.5" "842.4" "819.9" "861.7" "747.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8364348392468163032" "False" "High" "IsMasterProtein" "P04040" "Catalase OS=Homo sapiens OX=9606 GN=CAT PE=1 SV=3" "0.000" "False" "59.828" "25" "12" "31" "12" "527" "59.7" "7.39" "88.29" "12" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00199, Pf06628" "847" "ENSG00000121691" "CAT" "A8K6C0; B2RCZ9; D3DR07; hsa:847; P04040; Q2M1U4; Q4VXX5; Q9BWT9; Q9UC85" "Selenium micronutrient network; Folate metabolism; Amyotrophic lateral sclerosis (ALS); Oxidative stress response; Tryptophan metabolism; Male infertility; Arsenic metabolism and reactive oxygen species generation; DNA damage response (only ATM dependent)" "Neutrophil degranulation; Peroxisomal protein import; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Detoxification of Reactive Oxygen Species" "12" "0" "1.055" "1.006" "1.047" "1.077" "0.913" "1.207" "1.052" "1.113" "0.661" "1854.1" "1955.7" "1864.4" "1941.1" "1996.4" "1692.0" "2237.8" "1949.7" "2064.5" "1226.4" "" "" "" "" "" "" "" "" "" "" "1109.6" "1016.3" "1032.4" "911.3" "925.4" "866.2" "1040.5" "875.3" "1120.1" "1226.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3504989653461023373" "False" "High" "IsMasterProtein" "P51570" "Galactokinase OS=Homo sapiens OX=9606 GN=GALK1 PE=1 SV=1" "0.000" "False" "59.823" "30" "9" "26" "9" "392" "42.2" "6.46" "80.18" "9" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00288, Pf08544, Pf10509" "2584" "ENSG00000108479" "GALK1" "B2RC07; B4E1G6; hsa:2584; P51570" "Disorders of galactose metabolism" "Galactose catabolism; Defective GALK1 causes GALCT2" "3" "0" "0.984" "0.916" "1.208" "1.078" "1.084" "1.195" "1.171" "1.067" "0.944" "971.4" "955.4" "889.5" "1173.0" "1047.0" "1053.3" "1161.0" "1137.5" "1036.5" "917.4" "" "" "" "" "" "" "" "" "" "" "581.4" "496.5" "492.6" "550.7" "485.3" "539.2" "539.8" "510.7" "562.3" "917.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1817111684576735415" "False" "High" "IsMasterProtein" "O15511" "Actin-related protein 2/3 complex subunit 5 OS=Homo sapiens OX=9606 GN=ARPC5 PE=1 SV=3" "0.000" "False" "59.817" "60" "7" "27" "7" "151" "16.3" "5.67" "105.12" "7" "cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf04699" "10092" "ENSG00000162704" "ARPC5" "A6NEC4; hsa:10092; O15511; Q6PG42" "Pathogenic Escherichia coli infection; Regulation of actin cytoskeleton" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "8" "0" "0.979" "0.990" "1.073" "1.154" "0.972" "1.134" "1.034" "1.052" "0.654" "1631.1" "1597.0" "1614.0" "1749.5" "1882.2" "1584.6" "1849.6" "1686.6" "1715.4" "1065.9" "" "" "" "" "" "" "" "" "" "" "976.1" "829.9" "893.8" "821.3" "872.4" "811.2" "860.0" "757.2" "930.7" "1065.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "92619424180281671" "False" "High" "IsMasterProtein" "Q14141" "Septin-6 OS=Homo sapiens OX=9606 GN=SEPTIN6 PE=1 SV=4" "0.000" "False" "59.777" "26" "9" "28" "5" "434" "49.7" "6.67" "64.22" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "23157" "ENSG00000125354" "SEPTIN6" "hsa:23157; Q14141; Q5JTK0; Q969W5; Q96A13; Q96GR1; Q96P86; Q96P87" "2q37 copy number variation syndrome" "" "1" "2" "0.974" "1.006" "1.010" "0.909" "0.943" "0.896" "0.944" "0.926" "0.777" "631.7" "615.4" "635.2" "638.2" "574.5" "595.6" "566.3" "596.2" "585.1" "490.9" "" "" "" "" "" "" "" "" "" "" "378.1" "319.8" "351.8" "299.6" "266.3" "304.9" "263.3" "267.7" "317.4" "490.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-933507358187812304" "False" "High" "IsMasterProtein" "P48634" "Protein PRRC2A OS=Homo sapiens OX=9606 GN=PRRC2A PE=1 SV=3" "0.000" "False" "59.491" "9" "16" "26" "15" "2157" "228.7" "9.45" "64.65" "16" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "" "Pf07001" "7916" "ENSG00000204469; ENSG00000206427; ENSG00000225164; ENSG00000225748; ENSG00000226618; ENSG00000231370; ENSG00000231825" "PRRC2A" "B0UX77; B0UZE9; B0UZL3; hsa:7916; O95875; P48634; Q05BK4; Q4LE37; Q5SQ29; Q5SQ30; Q5ST84; Q5STX6; Q5STX7; Q68DW9; Q6P9P7; Q6PIN1; Q8MGQ9; Q96QC6" "" "" "0" "0" "1.035" "0.968" "1.013" "1.035" "0.980" "1.016" "1.027" "0.967" "0.450" "1231.8" "1275.1" "1191.9" "1248.0" "1275.4" "1206.6" "1251.2" "1264.9" "1191.3" "554.3" "" "" "" "" "" "" "" "" "" "" "737.1" "662.6" "660.1" "585.9" "591.1" "617.7" "581.8" "567.9" "646.3" "554.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-291186294764485320" "False" "High" "IsMasterProtein" "P33993" "DNA replication licensing factor MCM7 OS=Homo sapiens OX=9606 GN=MCM7 PE=1 SV=4" "0.000" "False" "59.376" "21" "13" "24" "13" "719" "81.3" "6.46" "62.28" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4176" "ENSG00000166508" "MCM7" "A4D2A1; A4D2A2; E9PGN9; hsa:4176; P33993; Q15076; Q96D34; Q96GL1" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "12" "0" "1.064" "1.060" "1.149" "1.253" "1.182" "1.149" "1.018" "1.159" "3.722" "657.2" "699.4" "696.5" "755.4" "823.6" "776.8" "755.3" "668.8" "761.5" "2446.1" "" "" "" "" "" "" "" "" "" "" "393.3" "363.5" "385.7" "354.6" "381.7" "397.7" "351.2" "300.2" "413.1" "2446.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8623682461858759698" "False" "High" "IsMasterProtein" "P54578" "Ubiquitin carboxyl-terminal hydrolase 14 OS=Homo sapiens OX=9606 GN=USP14 PE=1 SV=3" "0.000" "False" "59.330" "24" "11" "30" "11" "494" "56.0" "5.30" "73.01" "11" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00443" "9097" "ENSG00000101557" "USP14" "B7Z4N8; hsa:9097; J3QRZ5; P54578; Q53XY5" "" "Ub-specific processing proteases; Regulation of NF-kappa B signaling" "2" "0" "1.190" "1.228" "1.102" "1.179" "1.176" "1.063" "0.885" "1.128" "4.154" "429.6" "511.0" "527.6" "473.4" "506.6" "505.3" "456.8" "380.1" "484.5" "1784.5" "" "" "" "" "" "" "" "" "" "" "257.1" "265.5" "292.2" "222.3" "234.8" "258.7" "212.4" "170.6" "262.8" "1784.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8832352295829315313" "False" "High" "IsMasterProtein" "P09622" "Dihydrolipoyl dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=DLD PE=1 SV=2" "0.000" "False" "59.246" "22" "12" "34" "12" "509" "54.1" "7.85" "99.79" "12" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02852, Pf07992" "1738" "ENSG00000091140" "DLD" "B2R5X0; B4DHG0; B4DT69; hsa:1738; P09622; Q14131; Q14167; Q59EV8; Q8WTS4" "Fatty acid beta-oxidation; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Tryptophan metabolism; 7q11.23 copy number variation syndrome; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; 10q11.21q11.23 copy number variation syndrome; Metabolic Epileptic Disorders; TCA cycle (aka Krebs or citric acid cycle)" "Lysine catabolism; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Citric acid cycle (TCA cycle); Branched-chain amino acid catabolism; Mitochondrial protein degradation; Glycine degradation" "19" "0" "0.984" "0.949" "0.946" "0.958" "0.869" "1.019" "0.944" "0.989" "0.633" "4039.2" "3974.3" "3831.8" "3822.3" "3869.1" "3510.4" "4115.6" "3813.6" "3996.0" "2558.7" "" "" "" "" "" "" "" "" "" "" "2417.2" "2065.3" "2122.0" "1794.5" "1793.4" "1797.1" "1913.7" "1712.1" "2168.0" "2558.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3757999433169180156" "False" "High" "IsMasterProtein" "Q9NTJ3" "Structural maintenance of chromosomes protein 4 OS=Homo sapiens OX=9606 GN=SMC4 PE=1 SV=2" "0.000" "False" "59.145" "12" "15" "17" "15" "1288" "147.1" "6.79" "48.56" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "10051" "ENSG00000113810" "SMC4" "A6NLT9; D3DNL8; hsa:10051; O95752; Q8NDL4; Q9NTJ3; Q9UNT9" "Ciliary landscape" "Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes" "3" "0" "1.076" "1.009" "1.151" "1.171" "1.026" "1.252" "0.714" "0.988" "7.085" "365.2" "393.1" "368.3" "420.4" "427.7" "374.5" "457.2" "260.9" "360.8" "2587.2" "" "" "" "" "" "" "" "" "" "" "218.5" "204.3" "203.9" "197.4" "198.2" "191.7" "212.6" "117.1" "195.7" "2587.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5275540959932174837" "False" "High" "IsMasterProtein" "Q14847" "LIM and SH3 domain protein 1 OS=Homo sapiens OX=9606 GN=LASP1 PE=1 SV=2" "0.000" "False" "59.069" "45" "12" "37" "12" "261" "29.7" "7.05" "101.82" "12" "transport" "cytoskeleton;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00412, Pf00880, Pf14604" "3927" "ENSG00000002834" "LASP1" "B4DGQ0; hsa:3927; Q14847; Q96ED2; Q96IG0" "17q12 copy number variation syndrome" "" "1" "0" "0.975" "0.982" "0.939" "1.000" "0.993" "1.013" "1.106" "0.975" "0.458" "2493.5" "2430.2" "2447.5" "2342.4" "2494.7" "2476.7" "2525.0" "2757.5" "2431.9" "1140.8" "" "" "" "" "" "" "" "" "" "" "1492.2" "1262.9" "1355.4" "1099.7" "1156.3" "1267.9" "1174.1" "1238.0" "1319.4" "1140.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7785579833791404998" "False" "High" "IsMasterProtein" "P17980" "26S proteasome regulatory subunit 6A OS=Homo sapiens OX=9606 GN=PSMC3 PE=1 SV=3" "0.000" "False" "58.963" "43" "17" "38" "17" "439" "49.2" "5.24" "69.37" "17" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5702" "ENSG00000165916" "PSMC3" "B2R8V1; hsa:5702; P17980; Q3B757; Q3B865; Q53HU5; Q6GPG8; Q6IBS1; Q96HD3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Neutrophil degranulation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; UCH proteinases; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "0.995" "0.968" "1.049" "1.061" "1.097" "1.040" "1.107" "1.044" "0.709" "1411.8" "1404.7" "1366.9" "1481.2" "1498.1" "1548.4" "1468.1" "1562.8" "1474.1" "1000.6" "" "" "" "" "" "" "" "" "" "" "844.9" "730.0" "757.0" "695.4" "694.4" "792.7" "682.6" "701.6" "799.8" "1000.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5988193438521902409" "False" "High" "IsMasterProtein" "P26640" "Valine--tRNA ligase OS=Homo sapiens OX=9606 GN=VARS1 PE=1 SV=4" "0.000" "False" "58.837" "12" "12" "15" "12" "1264" "140.4" "7.59" "46.78" "12" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "other molecular function" "Pf00043, Pf00133, Pf08264" "7407" "ENSG00000096171; ENSG00000204394; ENSG00000224264; ENSG00000226589; ENSG00000231116" "VARS1" "B0V1N1; B4DZ61; hsa:7407; P26640; Q5JQ90; Q96E77; Q9UQM2" "Amino acid metabolism" "Cytosolic tRNA aminoacylation" "2" "0" "0.997" "0.924" "0.940" "1.101" "1.073" "0.865" "0.681" "0.962" "3.870" "255.2" "254.4" "235.7" "239.8" "280.8" "273.7" "220.7" "173.8" "245.5" "987.4" "" "" "" "" "" "" "" "" "" "" "152.7" "132.2" "130.5" "112.6" "130.2" "140.1" "102.6" "78.0" "133.2" "987.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4858909322532710110" "False" "High" "IsMasterProtein" "Q16881" "Thioredoxin reductase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TXNRD1 PE=1 SV=3" "0.000" "False" "58.704" "19" "11" "43" "11" "649" "70.9" "7.39" "133.89" "11" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00462, Pf02852, Pf07992" "7296" "ENSG00000198431" "TXNRD1" "B7Z1F4; B7Z3Y8; B7Z904; E9PMY9; F5H780; hsa:7296; Q16881; Q6FI31; Q6VB40; Q6VB41; Q6VB42; Q6VBP2; Q6VBP3; Q6VBP4; Q6VBP5; Q6VBP9; Q6VBQ0; Q6YNQ1; Q76P53; Q7LA96; Q8WVC8; Q99475; Q9UES8; Q9UH79" "Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Selenium metabolism and selenoproteins; Nuclear receptors meta-pathway; NRF2 pathway; Oxidative stress response; Ferroptosis" "Detoxification of Reactive Oxygen Species; PPARA activates gene expression; TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates; NFE2L2 regulating anti-oxidant/detoxification enzymes; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se; Uptake and function of diphtheria toxin; Metabolism of ingested MeSeO2H into MeSeH" "16" "0" "0.976" "0.990" "0.991" "0.954" "0.990" "0.916" "1.025" "0.955" "0.578" "2874.8" "2804.7" "2846.5" "2847.9" "2742.8" "2846.3" "2632.4" "2945.5" "2744.7" "1660.5" "" "" "" "" "" "" "" "" "" "" "1720.4" "1457.5" "1576.3" "1337.0" "1271.3" "1457.1" "1224.0" "1322.4" "1489.1" "1660.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1534536598926653536" "False" "High" "IsMasterProtein" "P05198" "Eukaryotic translation initiation factor 2 subunit 1 OS=Homo sapiens OX=9606 GN=EIF2S1 PE=1 SV=3" "0.000" "False" "58.676" "48" "15" "44" "15" "315" "36.1" "5.08" "122.40" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf00575, Pf07541" "1965" "ENSG00000134001" "EIF2S1" "hsa:1965; P05198" "Translation factors; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebola virus infection in host; Nonalcoholic fatty liver disease; Measles virus infection; Unfolded protein response; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Alzheimer's disease" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; PKR-mediated signaling; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "21" "0" "1.003" "0.980" "1.047" "1.013" "1.067" "0.975" "1.099" "1.055" "0.745" "2839.5" "2848.7" "2783.6" "2973.2" "2875.8" "3030.1" "2768.8" "3119.7" "2997.0" "2114.2" "" "" "" "" "" "" "" "" "" "" "1699.3" "1480.3" "1541.5" "1395.9" "1333.0" "1551.2" "1287.4" "1400.5" "1626.0" "2114.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4445993330794884217" "False" "High" "IsMasterProtein" "P54577" "Tyrosine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=YARS1 PE=1 SV=4" "0.000" "False" "58.579" "28" "16" "33" "16" "528" "59.1" "7.05" "86.19" "16" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00579, Pf01588" "8565" "ENSG00000134684" "YARS1" "B3KWK4; D3DPQ4; hsa:8565; O43276; P54577; Q53EN1" "Nephrotic syndrome" "Cytosolic tRNA aminoacylation" "2" "0" "0.988" "1.017" "1.075" "1.044" "1.023" "1.061" "0.632" "0.981" "5.941" "911.7" "900.7" "927.3" "979.6" "951.7" "932.8" "966.9" "576.1" "894.4" "5416.6" "" "" "" "" "" "" "" "" "" "" "545.6" "468.1" "513.5" "459.9" "441.1" "477.5" "449.6" "258.6" "485.3" "5416.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5432753500567823498" "False" "High" "IsMasterProtein" "O75390" "Citrate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=CS PE=1 SV=2" "0.000" "False" "58.506" "27" "12" "59" "12" "466" "51.7" "8.32" "155.08" "12" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00285" "1431" "ENSG00000062485" "CS" "hsa:1431; O75390; Q71UT9; Q7KZH0; Q96FZ8; Q9BWN8" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein import; Mitochondrial protein degradation" "7" "0" "0.976" "0.890" "1.006" "0.955" "0.963" "0.940" "0.913" "0.919" "1.704" "2313.4" "2258.7" "2059.2" "2327.0" "2208.4" "2227.7" "2174.1" "2111.5" "2127.0" "3940.9" "" "" "" "" "" "" "" "" "" "" "1384.4" "1173.7" "1140.3" "1092.5" "1023.6" "1140.4" "1010.9" "947.9" "1154.0" "3940.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3813014236257881133" "False" "High" "IsMasterProtein" "P21291" "Cysteine and glycine-rich protein 1 OS=Homo sapiens OX=9606 GN=CSRP1 PE=1 SV=3" "0.000" "False" "58.229" "52" "8" "37" "8" "193" "20.6" "8.57" "100.60" "8" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412" "1465" "ENSG00000159176" "CSRP1" "A8K268; hsa:1465; P21291; Q5U0J2" "MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling" "MTF1 activates gene expression" "3" "0" "1.008" "1.040" "1.002" "1.027" "1.037" "1.029" "1.150" "1.017" "0.522" "1327.3" "1337.2" "1380.7" "1329.7" "1363.7" "1376.1" "1366.3" "1526.9" "1349.2" "693.2" "" "" "" "" "" "" "" "" "" "" "794.3" "694.9" "764.6" "624.3" "632.1" "704.5" "635.3" "685.5" "732.0" "693.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2914348929085593862" "False" "High" "IsMasterProtein" "Q96F07" "Cytoplasmic FMR1-interacting protein 2 OS=Homo sapiens OX=9606 GN=CYFIP2 PE=1 SV=2" "0.000" "False" "57.800" "16" "19" "23" "19" "1278" "148.3" "7.31" "57.91" "19" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05994, Pf07159" "26999" "ENSG00000055163" "CYFIP2" "A6NLT2; D3DQJ3; hsa:26999; Q53EN5; Q96F07; Q9NTK4; Q9ULQ2; Q9UN29" "Fragile X syndrome; Regulation of actin cytoskeleton" "Regulation of actin dynamics for phagocytic cup formation; RAC1 GTPase cycle; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway" "7" "0" "1.077" "0.997" "1.110" "1.112" "1.095" "1.119" "1.048" "1.017" "2.046" "853.5" "919.5" "851.3" "947.3" "948.7" "934.9" "955.0" "894.7" "867.8" "1746.0" "" "" "" "" "" "" "" "" "" "" "510.8" "477.8" "471.5" "444.7" "439.7" "478.6" "444.1" "401.7" "470.8" "1746.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8545908257350266971" "False" "High" "IsMasterProtein" "O15144" "Actin-related protein 2/3 complex subunit 2 OS=Homo sapiens OX=9606 GN=ARPC2 PE=1 SV=1" "0.000" "False" "57.767" "33" "10" "42" "10" "300" "34.3" "7.36" "107.11" "10" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf04045" "10109" "ENSG00000163466" "ARPC2" "hsa:10109; O15144; Q92801; Q9P1D4" "Pathogenic Escherichia coli infection" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "6" "0" "0.927" "0.950" "0.964" "0.884" "1.063" "0.919" "1.028" "0.976" "0.656" "3389.6" "3142.0" "3219.6" "3268.1" "2996.7" "3603.3" "3114.2" "3483.9" "3307.9" "2223.4" "" "" "" "" "" "" "" "" "" "" "2028.5" "1632.8" "1783.0" "1534.3" "1389.0" "1844.6" "1448.0" "1564.0" "1794.7" "2223.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4305624722430213023" "False" "High" "IsMasterProtein" "Q9H4A3" "Serine/threonine-protein kinase WNK1 OS=Homo sapiens OX=9606 GN=WNK1 PE=1 SV=2" "0.000" "False" "57.490" "7" "17" "30" "17" "2382" "250.6" "6.34" "76.05" "17" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf12202" "65125" "ENSG00000060237" "WNK1" "A1L4B0; C5HTZ5; C5HTZ6; C5HTZ7; H6WZW3; hsa:65125; O15052; P54963; Q4VBX9; Q6IFS5; Q86WL5; Q8N673; Q96CZ6; Q9H4A3; Q9P1S9" "Ciliary landscape" "Stimuli-sensing channels" "2" "0" "1.008" "0.970" "1.117" "1.038" "1.038" "1.075" "1.059" "1.078" "1.103" "1168.1" "1176.9" "1133.0" "1304.3" "1213.0" "1212.8" "1255.6" "1237.4" "1259.7" "1288.2" "" "" "" "" "" "" "" "" "" "" "699.0" "611.6" "627.4" "612.3" "562.2" "620.8" "583.8" "555.5" "683.4" "1288.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5974744531153524067" "False" "High" "IsMasterProtein" "Q01581" "Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=HMGCS1 PE=1 SV=2" "0.000" "False" "57.469" "20" "11" "50" "11" "520" "57.3" "5.41" "147.81" "11" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01154, Pf08540" "3157" "ENSG00000112972" "HMGCS1" "B2RDL8; hsa:3157; Q01581" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); PPARA activates gene expression; Cholesterol biosynthesis" "13" "0" "0.957" "0.941" "0.919" "0.926" "0.881" "1.032" "1.005" "1.077" "0.587" "5712.3" "5465.1" "5374.6" "5248.2" "5286.8" "5032.9" "5896.4" "5742.0" "6151.5" "3351.9" "" "" "" "" "" "" "" "" "" "" "3418.5" "2840.0" "2976.3" "2463.9" "2450.5" "2576.5" "2741.7" "2577.8" "3337.4" "3351.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6836075231128367811" "False" "High" "IsMasterProtein" "Q15008" "26S proteasome non-ATPase regulatory subunit 6 OS=Homo sapiens OX=9606 GN=PSMD6 PE=1 SV=1" "0.000" "False" "57.457" "32" "15" "40" "15" "389" "45.5" "5.62" "98.74" "15" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01399, Pf10602, Pf21154" "9861" "ENSG00000163636" "PSMD6" "A8K2E0; E9PHI9; hsa:9861; Q15008; Q6UV22" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; ABC-family proteins mediated transport; Neutrophil degranulation; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Interleukin-1 signaling; Separation of Sister Chromatids; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "0.972" "0.886" "0.972" "0.952" "0.973" "0.971" "0.980" "0.935" "0.801" "2422.6" "2354.1" "2146.6" "2353.7" "2307.2" "2358.1" "2353.0" "2374.5" "2265.6" "1940.9" "" "" "" "" "" "" "" "" "" "" "1449.8" "1223.3" "1188.7" "1105.0" "1069.4" "1207.2" "1094.1" "1066.0" "1229.2" "1940.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6737848688669361571" "False" "High" "IsMasterProtein" "Q9UNZ2" "NSFL1 cofactor p47 OS=Homo sapiens OX=9606 GN=NSFL1C PE=1 SV=2" "0.000" "False" "57.127" "35" "12" "22" "12" "370" "40.5" "5.10" "62.48" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00789, Pf08059, Pf14555" "55968" "ENSG00000088833" "NSFL1C" "A2A2L1; B2RD74; hsa:55968; Q5JXA4; Q5JXA5; Q7Z533; Q9H102; Q9NVL9; Q9UI06; Q9UNZ2" "Alstrom syndrome" "RHOH GTPase cycle" "2" "0" "1.095" "1.120" "1.098" "1.088" "1.048" "1.017" "0.999" "1.027" "1.463" "880.9" "964.8" "986.8" "967.2" "958.7" "922.9" "896.0" "880.0" "904.3" "1289.1" "" "" "" "" "" "" "" "" "" "" "527.2" "501.4" "546.4" "454.1" "444.4" "472.4" "416.6" "395.1" "490.6" "1289.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3480641512252917896" "False" "High" "IsMasterProtein" "Q9NRF8" "CTP synthase 2 OS=Homo sapiens OX=9606 GN=CTPS2 PE=1 SV=1" "0.000" "False" "56.955" "20" "12" "29" "9" "586" "65.6" "6.90" "77.70" "12" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00117, Pf06418, Pf07722" "56474" "ENSG00000047230" "CTPS2" "B3KWM2; hsa:56474; Q9BRI0; Q9H809; Q9H8K9; Q9NRF8" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "0.953" "0.908" "1.009" "0.981" "1.016" "0.908" "0.981" "0.965" "0.643" "906.7" "864.4" "822.8" "914.8" "889.4" "921.0" "823.6" "889.2" "875.0" "582.9" "" "" "" "" "" "" "" "" "" "" "542.6" "449.2" "455.7" "429.5" "412.2" "471.5" "383.0" "399.2" "474.7" "582.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3988620745573507049" "False" "High" "IsMasterProtein" "P55786" "Puromycin-sensitive aminopeptidase OS=Homo sapiens OX=9606 GN=NPEPPS PE=1 SV=2" "0.000" "False" "56.954" "19" "17" "24" "17" "919" "103.2" "5.72" "67.70" "17" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "9520" "ENSG00000141279" "NPEPPS" "B7Z463; hsa:9520; P55786; Q6P145; Q9NP16; Q9UEM2" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.033" "1.053" "1.121" "1.070" "1.026" "1.064" "1.028" "1.038" "1.894" "1149.2" "1186.7" "1209.8" "1287.8" "1229.6" "1178.6" "1223.3" "1181.9" "1192.9" "2176.1" "" "" "" "" "" "" "" "" "" "" "687.7" "616.7" "670.0" "604.6" "569.9" "603.3" "568.8" "530.6" "647.2" "2176.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5829960447854698720" "False" "High" "IsMasterProtein" "O43399" "Tumor protein D54 OS=Homo sapiens OX=9606 GN=TPD52L2 PE=1 SV=2" "0.000" "False" "56.915" "42" "7" "24" "7" "206" "22.2" "5.36" "71.58" "7" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf04201" "7165" "ENSG00000101150" "TPD52L2" "B4DPJ6; E1P5G7; hsa:7165; O43398; O43399; Q5JWU5; Q5JWU6; Q5JWU8; Q5U0E0; Q9H3Z6" "" "" "0" "0" "1.082" "1.037" "1.140" "1.188" "1.169" "1.273" "1.305" "1.182" "0.645" "712.0" "770.5" "738.6" "811.3" "845.5" "832.4" "906.3" "929.4" "841.5" "459.5" "" "" "" "" "" "" "" "" "" "" "426.1" "400.4" "409.0" "380.9" "391.9" "426.1" "421.4" "417.2" "456.5" "459.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1938619972574952291" "False" "High" "IsMasterProtein" "Q9ULW0" "Targeting protein for Xklp2 OS=Homo sapiens OX=9606 GN=TPX2 PE=1 SV=2" "0.000" "False" "56.512" "15" "12" "23" "12" "747" "85.6" "9.23" "65.19" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06886, Pf09041, Pf12214" "22974" "ENSG00000088325" "TPX2" "hsa:22974; Q96RR5; Q9H1R4; Q9NRA3; Q9UFN9; Q9UL00; Q9ULW0; Q9Y2M1" "Gastric cancer network 1" "AURKA Activation by TPX2; Regulation of TP53 Activity through Phosphorylation" "3" "0" "1.058" "1.020" "0.979" "1.049" "1.102" "1.149" "1.168" "1.093" "1.104" "1482.0" "1568.2" "1512.0" "1450.7" "1554.6" "1633.0" "1702.2" "1731.6" "1619.9" "1636.8" "" "" "" "" "" "" "" "" "" "" "886.9" "814.9" "837.3" "681.1" "720.6" "836.0" "791.5" "777.4" "878.9" "1636.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2847148615950550488" "False" "High" "IsMasterProtein" "P20700" "Lamin-B1 OS=Homo sapiens OX=9606 GN=LMNB1 PE=1 SV=2" "0.000" "False" "56.502" "24" "14" "21" "12" "586" "66.4" "5.16" "61.86" "14" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;nucleus" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00038, Pf00932" "4001" "ENSG00000113368" "LMNB1" "B2R6J6; hsa:4001; P20700; Q3SYN7; Q96EI6" "Fas ligand pathway and stress induction of heat shock proteins; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "Meiotic synapsis; RHOD GTPase cycle; RHOF GTPase cycle; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina; Breakdown of the nuclear lamina; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "14" "2" "1.076" "1.248" "1.038" "1.190" "1.032" "1.152" "1.110" "1.179" "1.135" "1320.4" "1420.4" "1648.3" "1370.5" "1571.2" "1362.3" "1521.2" "1466.3" "1556.8" "1498.5" "" "" "" "" "" "" "" "" "" "" "790.2" "738.1" "912.8" "643.4" "728.3" "697.4" "707.3" "658.3" "844.6" "1498.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "516954531369469772" "False" "High" "IsMasterProtein" "P60900" "Proteasome subunit alpha type-6 OS=Homo sapiens OX=9606 GN=PSMA6 PE=1 SV=1" "0.000" "False" "56.360" "38" "9" "47" "9" "246" "27.4" "6.76" "143.64" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00227, Pf10584" "5687" "ENSG00000100902" "PSMA6" "B2R7J9; B4DQR4; B4DXJ9; hsa:5687; P34062; P60900; Q6IB60" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "1.012" "1.048" "1.071" "1.053" "0.970" "1.019" "1.070" "1.098" "0.654" "2368.3" "2396.1" "2481.4" "2536.2" "2494.0" "2298.2" "2413.2" "2534.4" "2599.4" "1549.7" "" "" "" "" "" "" "" "" "" "" "1417.3" "1245.1" "1374.1" "1190.7" "1156.0" "1176.5" "1122.1" "1137.8" "1410.3" "1549.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3394918450034897638" "False" "High" "IsMasterProtein" "P55884" "Eukaryotic translation initiation factor 3 subunit B OS=Homo sapiens OX=9606 GN=EIF3B PE=1 SV=3" "0.000" "False" "56.328" "17" "13" "23" "13" "814" "92.4" "5.00" "58.80" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08662" "8662" "ENSG00000106263" "EIF3B" "A4D208; hsa:8662; P55884; Q2NL77; Q9UMF9" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "0.988" "1.137" "1.050" "1.062" "1.014" "1.135" "0.804" "1.152" "4.217" "317.1" "313.3" "360.5" "332.9" "336.7" "321.5" "359.8" "255.0" "365.4" "1337.3" "" "" "" "" "" "" "" "" "" "" "189.8" "162.8" "199.6" "156.3" "156.1" "164.6" "167.3" "114.5" "198.2" "1337.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4137218576109141814" "False" "High" "IsMasterProtein" "Q06210" "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 OS=Homo sapiens OX=9606 GN=GFPT1 PE=1 SV=3" "0.000" "False" "56.195" "20" "13" "28" "13" "699" "78.8" "7.11" "69.81" "13" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01380, Pf13522" "2673" "ENSG00000198380" "GFPT1" "hsa:2673; Q06210; Q53QE6; Q9BXF8" "UDP-derived sugars synthesis in fibroblasts" "XBP1(S) activates chaperone genes; Synthesis of UDP-N-acetyl-glucosamine; Defective GFPT1 causes CMSTA1" "4" "0" "1.137" "1.014" "1.109" "1.037" "1.160" "0.992" "1.158" "1.085" "0.824" "1255.4" "1427.5" "1273.5" "1392.2" "1302.2" "1456.9" "1245.0" "1453.9" "1362.5" "1034.9" "" "" "" "" "" "" "" "" "" "" "751.3" "741.8" "705.2" "653.6" "603.6" "745.8" "578.9" "652.7" "739.2" "1034.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3042753504910158627" "False" "High" "IsMasterProtein" "P13804" "Electron transfer flavoprotein subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ETFA PE=1 SV=1" "0.000" "False" "56.037" "38" "11" "40" "11" "333" "35.1" "8.38" "115.69" "11" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00766, Pf01012" "2108" "ENSG00000140374" "ETFA" "B4DT43; hsa:2108; P13804; Q53XN3" "" "Respiratory electron transport" "1" "0" "0.997" "1.026" "1.013" "0.924" "1.041" "0.907" "1.044" "0.964" "0.726" "2226.8" "2219.6" "2285.7" "2256.0" "2057.3" "2317.7" "2020.3" "2324.2" "2147.2" "1616.7" "" "" "" "" "" "" "" "" "" "" "1332.6" "1153.4" "1265.8" "1059.1" "953.6" "1186.5" "939.4" "1043.4" "1165.0" "1616.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1011976368699827672" "False" "High" "IsMasterProtein" "P41091" "Eukaryotic translation initiation factor 2 subunit 3 OS=Homo sapiens OX=9606 GN=EIF2S3 PE=1 SV=3" "0.000" "False" "55.979" "26" "11" "41" "11" "472" "51.1" "8.40" "126.13" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144, Pf09173" "1968" "ENSG00000130741" "EIF2S3" "A0A024RBY4; A8K2Y2; B2R5N2; B5BTZ4; hsa:1968; P41091; Q53HK3" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "PERK regulates gene expression; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; PKR-mediated signaling; Formation of the ternary complex, and subsequently, the 43S complex; Response of EIF2AK1 (HRI) to heme deficiency; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "14" "0" "1.003" "0.969" "1.063" "0.991" "1.040" "1.000" "1.089" "1.013" "0.748" "3732.8" "3744.7" "3617.5" "3966.9" "3697.7" "3882.6" "3733.9" "4063.3" "3780.0" "2793.4" "" "" "" "" "" "" "" "" "" "" "2233.9" "1946.0" "2003.3" "1862.3" "1713.9" "1987.6" "1736.2" "1824.2" "2050.8" "2793.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8484028389043526679" "False" "High" "IsMasterProtein" "P13010" "X-ray repair cross-complementing protein 5 OS=Homo sapiens OX=9606 GN=XRCC5 PE=1 SV=3" "0.000" "False" "55.913" "16" "10" "21" "10" "732" "82.7" "5.81" "58.18" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf02735, Pf03730, Pf03731, Pf08785" "7520" "ENSG00000079246" "XRCC5" "A8K3X5; hsa:7520; P13010; Q0Z7V0; Q4VBQ5; Q53HH7; Q7M4N0; Q9UCQ0; Q9UCQ1" "Non-homologous end joining; Male infertility; DNA repair pathways, full network; p53 transcriptional gene network" "Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN" "9" "0" "0.985" "1.189" "1.148" "1.098" "1.010" "1.002" "0.291" "1.110" "10.422" "493.9" "486.3" "587.3" "566.8" "542.5" "499.0" "495.0" "143.8" "548.4" "5147.4" "" "" "" "" "" "" "" "" "" "" "295.6" "252.7" "325.2" "266.1" "251.5" "255.4" "230.2" "64.6" "297.5" "5147.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4997024104720897707" "False" "High" "IsMasterProtein" "Q9BZK7" "F-box-like/WD repeat-containing protein TBL1XR1 OS=Homo sapiens OX=9606 GN=TBL1XR1 PE=1 SV=1" "0.000" "False" "55.839" "24" "9" "14" "9" "514" "55.6" "5.55" "50.14" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf08513" "79718" "ENSG00000177565" "TBL1XR1" "D3DNQ9; hsa:79718; Q14DC3; Q9BZK7; Q9H2I1; Q9H9A1" "Rett syndrome" "HCMV Early Events; HDACs deacetylate histones; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression" "20" "0" "1.009" "0.933" "0.885" "0.870" "1.007" "0.955" "0.913" "0.903" "1.125" "786.4" "793.7" "733.6" "695.6" "684.4" "792.0" "750.8" "718.3" "709.8" "884.6" "" "" "" "" "" "" "" "" "" "" "470.6" "412.4" "406.2" "326.6" "317.2" "405.4" "349.1" "322.5" "385.1" "884.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7590147556392166876" "False" "High" "IsMasterProtein" "P07384" "Calpain-1 catalytic subunit OS=Homo sapiens OX=9606 GN=CAPN1 PE=1 SV=1" "0.000" "False" "55.821" "21" "16" "30" "16" "714" "81.8" "5.67" "80.87" "16" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00648, Pf01067, Pf13833" "823" "ENSG00000014216" "CAPN1" "P07384; Q2TTR0; Q6DHV4" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Formation of the cornified envelope; Degradation of the extracellular matrix; Neutrophil degranulation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "7" "0" "0.939" "0.914" "0.970" "0.999" "1.005" "0.989" "0.991" "0.966" "0.652" "2100.6" "1971.4" "1920.4" "2037.2" "2097.5" "2110.9" "2076.8" "2081.4" "2028.8" "1369.2" "" "" "" "" "" "" "" "" "" "" "1257.1" "1024.5" "1063.4" "956.4" "972.2" "1080.6" "965.6" "934.4" "1100.7" "1369.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4682343242687865588" "False" "High" "IsMasterProtein" "O43818" "U3 small nucleolar RNA-interacting protein 2 OS=Homo sapiens OX=9606 GN=RRP9 PE=1 SV=1" "0.000" "False" "55.659" "27" "13" "25" "13" "475" "51.8" "7.85" "66.09" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00400" "9136" "ENSG00000114767" "RRP9" "B2R996; hsa:9136; O43818; Q8IZ30" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.045" "0.933" "1.018" "1.007" "0.853" "0.967" "0.940" "0.959" "0.492" "969.1" "1012.9" "904.2" "986.5" "975.8" "826.4" "937.1" "911.0" "929.6" "477.1" "" "" "" "" "" "" "" "" "" "" "579.9" "526.4" "500.7" "463.1" "452.3" "423.0" "435.8" "409.0" "504.3" "477.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7835862942369075388" "False" "High" "IsMasterProtein" "P06753" "Tropomyosin alpha-3 chain OS=Homo sapiens OX=9606 GN=TPM3 PE=1 SV=2" "0.000" "False" "55.401" "31" "12" "53" "5" "285" "32.9" "4.72" "147.71" "12" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf00261" "7170" "ENSG00000143549" "TPM3" "D3DV71; hsa:7170; P06753; P12324; Q2QD06; Q5VU58; Q5VU63; Q5VU66; Q5VU71; Q5VU72; Q8TCG3; Q969Q2; Q9NQH8" "Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Striated muscle contraction pathway; VEGFA-VEGFR2 signaling" "Signaling by ALK fusions and activated point mutants; RHOV GTPase cycle; Smooth Muscle Contraction; Striated Muscle Contraction" "7" "0" "0.989" "1.068" "1.044" "0.992" "0.901" "1.008" "0.920" "0.900" "0.819" "1332.3" "1318.3" "1423.0" "1391.3" "1321.9" "1201.1" "1343.5" "1225.4" "1198.7" "1091.5" "" "" "" "" "" "" "" "" "" "" "797.3" "685.1" "788.0" "653.2" "612.7" "614.9" "624.7" "550.1" "650.3" "1091.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4969785199518402327" "False" "High" "IsMasterProtein" "Q13098" "COP9 signalosome complex subunit 1 OS=Homo sapiens OX=9606 GN=GPS1 PE=1 SV=4" "0.000" "False" "55.377" "24" "11" "30" "11" "491" "55.5" "6.74" "85.56" "11" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01399, Pf10602, Pf21151" "2873" "ENSG00000169727" "GPS1" "hsa:2873; Q13098; Q8NA10; Q9BWL1" "" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER" "5" "0" "1.062" "1.016" "1.060" "1.016" "1.127" "1.000" "1.077" "1.016" "0.838" "1745.0" "1853.0" "1772.4" "1850.2" "1773.7" "1967.0" "1744.6" "1879.1" "1772.4" "1462.4" "" "" "" "" "" "" "" "" "" "" "1044.3" "963.0" "981.5" "868.6" "822.1" "1007.0" "811.2" "843.6" "961.6" "1462.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8610404900026586522" "False" "High" "IsMasterProtein" "P27797" "Calreticulin OS=Homo sapiens OX=9606 GN=CALR PE=1 SV=1" "0.000" "False" "55.218" "25" "12" "40" "12" "417" "48.1" "4.44" "97.62" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00262" "811" "ENSG00000179218" "CALR" "hsa:811; P27797; Q6IAT4; Q9UDG2" "Androgen receptor signaling pathway; Complement system; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling; GDNF signaling; Calcium regulation in cardiac cells" "ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Scavenging by Class A Receptors; Assembly of Viral Components at the Budding Site; Scavenging by Class F Receptors; ATF6 (ATF6-alpha) activates chaperone genes; Calnexin/calreticulin cycle" "13" "0" "1.062" "1.159" "1.085" "1.062" "1.065" "1.004" "0.769" "1.032" "3.933" "2011.6" "2136.2" "2330.8" "2182.7" "2135.4" "2142.8" "2019.2" "1546.1" "2076.5" "7912.3" "" "" "" "" "" "" "" "" "" "" "1203.8" "1110.1" "1290.7" "1024.7" "989.8" "1097.0" "938.9" "694.1" "1126.6" "7912.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2666399162137355267" "False" "High" "IsMasterProtein" "P38117" "Electron transfer flavoprotein subunit beta OS=Homo sapiens OX=9606 GN=ETFB PE=1 SV=3" "0.000" "False" "55.024" "54" "13" "59" "13" "255" "27.8" "8.10" "143.34" "13" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01012" "2109" "ENSG00000105379" "ETFB" "A8K766; B3KNY2; hsa:2109; P38117; Q6IBH7; Q71RF6; Q9Y3S7" "" "Respiratory electron transport; Protein methylation" "2" "0" "0.986" "0.946" "1.041" "0.991" "0.998" "0.985" "1.023" "0.958" "0.768" "2157.0" "2127.4" "2041.1" "2245.4" "2137.6" "2152.4" "2124.5" "2207.1" "2065.6" "1657.2" "" "" "" "" "" "" "" "" "" "" "1290.9" "1105.5" "1130.3" "1054.2" "990.8" "1101.9" "987.8" "990.8" "1120.7" "1657.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1887782222287180929" "False" "High" "IsMasterProtein" "Q9ULV4" "Coronin-1C OS=Homo sapiens OX=9606 GN=CORO1C PE=1 SV=1" "0.000" "False" "54.947" "23" "13" "26" "13" "474" "53.2" "7.08" "82.17" "13" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf16300" "23603" "ENSG00000110880" "CORO1C" "A7MAP0; A7MAP1; B3KU12; hsa:23603; Q9NSK5; Q9ULV4" "" "" "0" "0" "1.003" "0.992" "0.987" "0.936" "0.982" "0.929" "0.978" "1.027" "1.163" "1723.6" "1729.0" "1709.1" "1701.7" "1612.4" "1692.5" "1600.9" "1686.5" "1769.3" "2005.1" "" "" "" "" "" "" "" "" "" "" "1031.4" "898.5" "946.5" "798.9" "747.4" "866.4" "744.4" "757.1" "959.9" "2005.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2527179580342077355" "False" "High" "IsMasterProtein" "Q9NUQ9" "CYFIP-related Rac1 interactor B OS=Homo sapiens OX=9606 GN=CYRIB PE=1 SV=1" "0.000" "False" "54.821" "43" "10" "18" "10" "324" "36.7" "6.06" "49.68" "10" "cell organization and biogenesis;other biological processes" "non-structural extracellular;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf07159" "51571" "ENSG00000153310" "CYRIB" "hsa:51571; Q96AZ5; Q9NUQ9; Q9NW21; Q9NZE7" "" "Platelet degranulation" "1" "0" "1.237" "1.198" "1.191" "1.281" "1.313" "1.103" "1.293" "1.161" "0.981" "568.1" "702.6" "680.7" "676.9" "727.5" "745.8" "626.7" "734.4" "659.5" "557.1" "" "" "" "" "" "" "" "" "" "" "340.0" "365.1" "377.0" "317.8" "337.2" "381.8" "291.4" "329.7" "357.8" "557.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570733689934674061" "False" "High" "IsMasterProtein" "P61106" "Ras-related protein Rab-14 OS=Homo sapiens OX=9606 GN=RAB14 PE=1 SV=4" "0.000" "False" "54.579" "46" "9" "35" "8" "215" "23.9" "6.21" "100.26" "9" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "51552" "ENSG00000119396" "RAB14" "B3KR31; hsa:51552; P35287; P61106; Q5JVD4; Q6Q7K5; Q969L0; Q9UI11" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape" "Neutrophil degranulation; RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Synthesis of PIPs at the plasma membrane" "7" "1" "0.965" "0.892" "0.986" "0.954" "1.046" "0.951" "1.001" "0.951" "0.609" "2713.7" "2618.5" "2422.0" "2676.8" "2588.5" "2838.3" "2579.6" "2715.3" "2580.0" "1653.1" "" "" "" "" "" "" "" "" "" "" "1624.0" "1360.7" "1341.2" "1256.7" "1199.8" "1453.0" "1199.4" "1219.0" "1399.7" "1653.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3705631994362769923" "False" "High" "IsMasterProtein" "P11413" "Glucose-6-phosphate 1-dehydrogenase OS=Homo sapiens OX=9606 GN=G6PD PE=1 SV=4" "0.000" "False" "54.520" "27" "14" "25" "14" "515" "59.2" "6.84" "65.48" "14" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00479, Pf02781" "2539" "ENSG00000160211" "G6PD" "D3DWX9; hsa:2539; P11413; Q16000; Q16765; Q8IU70; Q8IU88; Q8IUA6; Q96PQ2" "Glutathione metabolism; Pentose phosphate metabolism; Cori cycle; Vitamin D receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; ATM signaling in development and disease ; Metabolic reprogramming in colon cancer; Vitamin D-sensitive calcium signaling in depression; Pentose phosphate pathway in senescent cells; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; Sulfation biotransformation reaction" "TP53 Regulates Metabolic Genes; NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway" "16" "0" "0.984" "0.935" "0.981" "0.993" "1.099" "0.959" "1.034" "1.042" "0.877" "964.1" "949.0" "901.3" "946.3" "957.6" "1059.3" "924.8" "996.5" "1004.9" "845.6" "" "" "" "" "" "" "" "" "" "" "577.0" "493.2" "499.1" "444.3" "443.9" "542.3" "430.0" "447.4" "545.2" "845.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-199396300438152648" "False" "High" "IsMasterProtein" "P25788" "Proteasome subunit alpha type-3 OS=Homo sapiens OX=9606 GN=PSMA3 PE=1 SV=2" "0.000" "False" "54.431" "37" "10" "60" "10" "255" "28.4" "5.33" "154.61" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf10584" "5684" "ENSG00000100567" "PSMA3" "B2RCK6; hsa:5684; P25788; Q86U83; Q8N1D8; Q9BS70" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; UCH proteinases; Regulation of RUNX3 expression and activity; ER-Phagosome pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Cross-presentation of soluble exogenous antigens (endosomes); Regulation of ornithine decarboxylase (ODC); Somitogenesis" "62" "0" "0.932" "0.934" "0.994" "0.984" "0.890" "0.989" "1.001" "0.993" "0.636" "3000.8" "2795.9" "2802.3" "2983.8" "2952.9" "2672.0" "2968.1" "3004.6" "2980.4" "1907.4" "" "" "" "" "" "" "" "" "" "" "1795.8" "1452.9" "1551.9" "1400.8" "1368.7" "1367.9" "1380.1" "1348.9" "1617.0" "1907.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5815145421053809259" "False" "High" "IsMasterProtein" "Q16543" "Hsp90 co-chaperone Cdc37 OS=Homo sapiens OX=9606 GN=CDC37 PE=1 SV=1" "0.000" "False" "54.205" "23" "9" "42" "9" "378" "44.4" "5.25" "107.40" "9" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf03234, Pf08564, Pf08565" "11140" "ENSG00000105401" "CDC37" "hsa:11140; Q16543; Q53YA2" "TNF-alpha signaling pathway; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Interactions between LOXL4 and oxidative stress pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "RHOBTB2 GTPase cycle; Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "27" "0" "1.088" "1.086" "1.127" "1.105" "0.919" "1.056" "0.962" "0.969" "0.789" "2321.8" "2525.9" "2521.3" "2616.7" "2564.7" "2134.2" "2451.1" "2234.0" "2250.2" "1832.4" "" "" "" "" "" "" "" "" "" "" "1389.4" "1312.6" "1396.2" "1228.5" "1188.8" "1092.5" "1139.7" "1002.9" "1220.8" "1832.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "654081652263858131" "False" "High" "IsMasterProtein" "Q12905" "Interleukin enhancer-binding factor 2 OS=Homo sapiens OX=9606 GN=ILF2 PE=1 SV=2" "0.000" "False" "54.173" "30" "10" "63" "10" "390" "43.0" "5.26" "168.59" "10" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf07528, Pf20965" "3608" "ENSG00000143621" "ILF2" "A6NDB0; B2R8G7; hsa:3608; Q12905; Q5SR10; Q5SR11; Q7L7R3; Q9BWD4; Q9P1N0" "B cell receptor signaling pathway" "Neutrophil degranulation; PKR-mediated signaling" "3" "0" "0.996" "0.959" "1.051" "1.020" "1.111" "0.977" "1.075" "1.009" "0.866" "2359.1" "2349.6" "2261.5" "2479.4" "2405.5" "2621.1" "2305.0" "2536.0" "2379.4" "2043.5" "" "" "" "" "" "" "" "" "" "" "1411.8" "1221.0" "1252.4" "1164.0" "1115.0" "1341.8" "1071.8" "1138.5" "1290.9" "2043.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2351772574129659372" "False" "High" "IsMasterProtein" "P35269" "General transcription factor IIF subunit 1 OS=Homo sapiens OX=9606 GN=GTF2F1 PE=1 SV=2" "0.000" "False" "53.807" "26" "9" "16" "9" "517" "58.2" "7.49" "55.88" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf05793" "2962" "ENSG00000125651" "GTF2F1" "B2RCS0; hsa:2962; P35269; Q9BWN0" "" "Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Estrogen-dependent gene expression; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "32" "0" "1.021" "0.985" "1.036" "1.026" "0.928" "1.012" "0.890" "0.946" "0.777" "433.0" "442.1" "426.6" "448.5" "444.1" "401.8" "438.3" "385.4" "409.8" "336.3" "" "" "" "" "" "" "" "" "" "" "259.1" "229.7" "236.2" "210.5" "205.9" "205.7" "203.8" "173.0" "222.3" "336.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2000149413272750326" "False" "High" "IsMasterProtein" "Q15907" "Ras-related protein Rab-11B OS=Homo sapiens OX=9606 GN=RAB11B PE=1 SV=4" "0.000" "False" "53.779" "54" "12" "51" "12" "218" "24.5" "5.94" "135.96" "12" "cell-cell signaling;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "9230" "ENSG00000185236" "RAB11B" "A5YM50; B2R7I4; B4DMK0; D6W671; hsa:9230; Q15907; Q2YDT2; Q5U0I1; Q6FHR0; Q6FI42; Q8NI07" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Intracellular trafficking proteins involved in CMT neuropathy; Vasopressin-regulated water reabsorption" "RAB geranylgeranylation; TBC/RABGAPs" "5" "0" "1.001" "0.953" "0.989" "1.022" "1.038" "0.989" "1.033" "1.031" "0.579" "3669.9" "3675.3" "3496.4" "3630.8" "3751.9" "3808.3" "3629.5" "3789.6" "3784.6" "2125.2" "" "" "" "" "" "" "" "" "" "" "2196.3" "1909.9" "1936.2" "1704.6" "1739.1" "1949.5" "1687.6" "1701.3" "2053.3" "2125.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8046944082778510554" "False" "High" "IsMasterProtein" "P32119" "Peroxiredoxin-2 OS=Homo sapiens OX=9606 GN=PRDX2 PE=1 SV=5" "0.000" "False" "53.641" "36" "8" "75" "7" "198" "21.9" "5.97" "222.52" "8" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00578, Pf10417" "7001" "ENSG00000167815" "PRDX2" "A8K0C0; hsa:7001; P31945; P32118; P32119; P35701; Q6FHG4; Q92763; Q9UC23" "Selenium micronutrient network; VEGFA-VEGFR2 signaling; HDAC6 interactions in the central nervous system" "TP53 Regulates Metabolic Genes; Detoxification of Reactive Oxygen Species; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "6" "0" "0.974" "0.989" "1.019" "0.980" "1.012" "0.970" "1.051" "1.021" "0.629" "5243.6" "5107.0" "5183.6" "5341.0" "5140.9" "5308.2" "5085.8" "5511.9" "5351.4" "3298.4" "" "" "" "" "" "" "" "" "" "" "3138.0" "2653.9" "2870.6" "2507.5" "2382.9" "2717.4" "2364.8" "2474.5" "2903.4" "3298.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2943690132932996841" "False" "High" "IsMasterProtein" "P10412" "Histone H1.4 OS=Homo sapiens OX=9606 GN=H1-4 PE=1 SV=2" "0.000" "False" "53.432" "31" "8" "63" "1" "219" "21.9" "11.03" "173.34" "8" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3008" "ENSG00000168298" "H1-4" "hsa:3008; P10412; Q4VB25" "Pathways affected in adenoid cystic carcinoma" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "3" "0" "1.114" "1.197" "0.937" "0.907" "1.017" "0.832" "0.892" "0.753" "0.724" "364.8" "406.5" "436.8" "341.7" "330.8" "371.0" "303.7" "325.5" "274.7" "264.3" "" "" "" "" "" "" "" "" "" "" "218.3" "211.2" "241.9" "160.4" "153.3" "189.9" "141.2" "146.1" "149.0" "264.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088102652964782572" "False" "High" "IsMasterProtein" "Q13310" "Polyadenylate-binding protein 4 OS=Homo sapiens OX=9606 GN=PABPC4 PE=1 SV=1" "0.000" "False" "53.430" "21" "12" "25" "8" "644" "70.7" "9.26" "62.21" "12" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00658" "8761" "ENSG00000090621" "PABPC4" "B1ANQ8; hsa:8761; Q13310; Q4VC03; Q6P0N3" "" "" "0" "0" "1.049" "1.281" "1.157" "1.210" "1.128" "1.131" "0.737" "1.149" "4.952" "492.5" "516.8" "631.1" "569.7" "596.1" "555.7" "557.2" "363.0" "565.7" "2439.0" "" "" "" "" "" "" "" "" "" "" "294.8" "268.6" "349.5" "267.4" "276.3" "284.5" "259.1" "163.0" "306.9" "2439.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2890284807861643792" "False" "High" "IsMasterProtein" "P22102" "Trifunctional purine biosynthetic protein adenosine-3 OS=Homo sapiens OX=9606 GN=GART PE=1 SV=1" "0.000" "False" "53.340" "14" "15" "45" "15" "1010" "107.7" "6.70" "124.78" "15" "other metabolic processes;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00551, Pf00586, Pf01071, Pf02769, Pf02843, Pf02844" "2618" "ENSG00000159131; ENSG00000262473" "GART" "A8K945; A8KA32; D3DSF3; D3DSF4; hsa:2618; O14659; P22102; Q52M77" "Folate metabolism; One-carbon metabolism; Metabolic reprogramming in colon cancer" "Purine ribonucleoside monophosphate biosynthesis" "4" "0" "1.009" "0.988" "1.077" "1.022" "1.067" "1.049" "0.826" "1.073" "3.637" "2026.5" "2045.6" "2001.7" "2182.7" "2071.8" "2163.0" "2125.3" "1674.7" "2174.2" "7369.3" "" "" "" "" "" "" "" "" "" "" "1212.7" "1063.0" "1108.5" "1024.7" "960.3" "1107.3" "988.2" "751.8" "1179.6" "7369.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-917642798524543660" "False" "High" "IsMasterProtein" "P52566" "Rho GDP-dissociation inhibitor 2 OS=Homo sapiens OX=9606 GN=ARHGDIB PE=1 SV=3" "0.000" "False" "53.332" "52" "12" "81" "12" "201" "23.0" "5.21" "193.00" "12" "signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf02115" "397" "ENSG00000111348" "ARHGDIB" "B5BU79; hsa:397; P52566" "Fas ligand pathway and stress induction of heat shock proteins; Vasopressin-regulated water reabsorption; G13 signaling pathway" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC3 GTPase cycle; RHOH GTPase cycle" "9" "0" "1.015" "1.100" "1.017" "1.082" "1.044" "0.990" "0.987" "1.027" "1.294" "5133.6" "5213.0" "5649.0" "5222.4" "5552.4" "5360.0" "5082.0" "5067.6" "5270.1" "6640.5" "" "" "" "" "" "" "" "" "" "" "3072.2" "2709.0" "3128.3" "2451.8" "2573.6" "2743.9" "2363.0" "2275.0" "2859.3" "6640.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602445909866352508" "False" "High" "IsMasterProtein" "P19338" "Nucleolin OS=Homo sapiens OX=9606 GN=NCL PE=1 SV=3" "0.000" "False" "53.233" "18" "15" "38" "15" "710" "76.6" "4.70" "105.25" "15" "developmental processes;other biological processes" "plasma membrane;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "4691" "ENSG00000115053" "NCL" "hsa:4691; P19338; Q53SK1; Q8NB06; Q9UCF0; Q9UDG1" "Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling" "Major pathway of rRNA processing in the nucleolus and cytosol; Respiratory syncytial virus (RSV) attachment and entry" "4" "0" "0.892" "1.007" "0.786" "0.815" "0.813" "0.729" "0.661" "0.740" "1.164" "1946.2" "1735.2" "1959.6" "1530.5" "1585.4" "1582.1" "1418.6" "1285.6" "1440.4" "2265.6" "" "" "" "" "" "" "" "" "" "" "1164.7" "901.7" "1085.2" "718.5" "734.9" "809.9" "659.6" "577.2" "781.5" "2265.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6656401588938308742" "False" "High" "IsMasterProtein" "Q14676" "Mediator of DNA damage checkpoint protein 1 OS=Homo sapiens OX=9606 GN=MDC1 PE=1 SV=3" "0.000" "False" "53.213" "9" "16" "33" "16" "2089" "226.5" "5.47" "68.72" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00498, Pf16589, Pf16770" "9656" "ENSG00000137337; ENSG00000206481; ENSG00000224587; ENSG00000225589; ENSG00000228575; ENSG00000231135; ENSG00000234012; ENSG00000237095" "MDC1" "A2AB04; A2BF04; A2RRA8; A7YY86; B0S8A2; hsa:9656; Q0EFC2; Q14676; Q2L6H7; Q2TAZ4; Q5JP55; Q5JP56; Q5ST83; Q68CQ3; Q86Z06; Q96QC2" "ATM signaling in development and disease ; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome" "SUMOylation of DNA damage response and repair proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TP53 Regulates Transcription of DNA Repair Genes; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "9" "0" "1.103" "1.111" "1.079" "1.157" "1.091" "1.259" "1.131" "1.239" "1.126" "347.8" "383.7" "386.4" "375.3" "402.4" "379.5" "437.8" "393.5" "431.0" "391.7" "" "" "" "" "" "" "" "" "" "" "208.1" "199.4" "214.0" "176.2" "186.5" "194.3" "203.6" "176.6" "233.8" "391.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5990763445808986334" "False" "High" "IsMasterProtein" "O75083" "WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=WDR1 PE=1 SV=4" "0.000" "False" "53.101" "19" "11" "40" "11" "606" "66.2" "6.65" "122.24" "11" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00400" "9948" "ENSG00000071127" "WDR1" "A8K6E9; A8MPU4; hsa:9948; O75083; O75313; Q8N6E5; Q9UG05; Q9UG78; Q9UQE0" "Hypertrophy model" "Platelet degranulation" "2" "0" "1.047" "1.007" "1.044" "0.987" "1.037" "0.971" "0.979" "0.991" "1.259" "2742.6" "2872.2" "2762.9" "2862.9" "2707.2" "2844.5" "2662.1" "2685.0" "2718.4" "3452.1" "" "" "" "" "" "" "" "" "" "" "1641.3" "1492.6" "1530.0" "1344.1" "1254.9" "1456.1" "1237.8" "1205.4" "1474.8" "3452.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7233412111740596343" "False" "High" "IsMasterProtein" "P19367" "Hexokinase-1 OS=Homo sapiens OX=9606 GN=HK1 PE=1 SV=3" "0.000" "False" "53.004" "14" "12" "31" "10" "917" "102.4" "6.80" "79.32" "12" "other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00349, Pf03727" "3098" "ENSG00000156515" "HK1" "E9PCK0; hsa:3098; O43443; O43444; O75574; P19367; Q5VTC3; Q96HC8; Q9NNZ4; Q9NNZ5" "Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Disorders of fructose metabolism; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "Glycolysis; Defective HK1 causes hexokinase deficiency (HK deficiency)" "12" "1" "1.003" "1.020" "1.132" "1.062" "1.113" "1.070" "1.131" "1.058" "1.135" "1214.5" "1218.0" "1239.4" "1374.8" "1290.0" "1351.5" "1299.0" "1374.0" "1284.5" "1377.8" "" "" "" "" "" "" "" "" "" "" "726.8" "632.9" "686.3" "645.4" "597.9" "691.9" "604.0" "616.8" "696.9" "1377.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1437948072660631583" "False" "High" "IsMasterProtein" "O60664" "Perilipin-3 OS=Homo sapiens OX=9606 GN=PLIN3 PE=1 SV=3" "0.000" "False" "52.947" "27" "9" "28" "9" "434" "47.0" "5.44" "70.12" "9" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf03036" "10226" "ENSG00000105355" "PLIN3" "A8K4Y9; hsa:10226; K7EQF4; O60664; Q53G77; Q9BS03; Q9UBD7; Q9UP92" "" "Late endosomal microautophagy; Triglyceride catabolism; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle; Lipophagy; Chaperone Mediated Autophagy" "6" "0" "1.046" "1.044" "0.999" "1.066" "0.952" "1.038" "1.063" "1.040" "0.735" "1225.5" "1281.5" "1279.8" "1224.8" "1306.5" "1166.7" "1272.1" "1302.4" "1274.9" "900.8" "" "" "" "" "" "" "" "" "" "" "733.4" "666.0" "708.7" "575.0" "605.6" "597.3" "591.5" "584.7" "691.7" "900.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2867565850229162791" "False" "High" "IsMasterProtein" "P12081" "Histidine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=HARS1 PE=1 SV=2" "0.000" "False" "52.940" "21" "11" "27" "8" "509" "57.4" "5.88" "80.50" "11" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00458, Pf03129, Pf13393" "3035" "ENSG00000170445" "HARS1" "B4DHQ1; B4DY73; D6REN6; hsa:3035; J3KNE5; P12081" "Allograft rejection" "Cytosolic tRNA aminoacylation" "2" "2" "0.999" "0.879" "0.993" "0.913" "0.990" "0.999" "1.023" "0.961" "0.657" "2197.9" "2195.6" "1932.3" "2183.4" "2006.0" "2176.8" "2195.1" "2247.4" "2112.9" "1443.2" "" "" "" "" "" "" "" "" "" "" "1315.3" "1141.0" "1070.1" "1025.1" "929.8" "1114.4" "1020.7" "1009.0" "1146.3" "1443.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2064458318068970757" "False" "High" "IsMasterProtein" "Q96QK1" "Vacuolar protein sorting-associated protein 35 OS=Homo sapiens OX=9606 GN=VPS35 PE=1 SV=2" "0.000" "False" "52.659" "19" "14" "37" "14" "796" "91.6" "5.49" "77.15" "14" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding" "Pf03635" "55737" "ENSG00000069329" "VPS35" "hsa:55737; Q561W2; Q96QK1; Q9H016; Q9H096; Q9H4P3; Q9H8J0; Q9NRS7; Q9NVG2; Q9NX80; Q9NZK2" "" "WNT ligand biogenesis and trafficking" "1" "0" "1.015" "0.965" "1.134" "1.043" "1.041" "1.042" "0.966" "1.001" "1.475" "1205.7" "1224.3" "1163.5" "1366.8" "1257.5" "1255.7" "1256.4" "1164.5" "1206.4" "1778.0" "" "" "" "" "" "" "" "" "" "" "721.5" "636.2" "644.3" "641.7" "582.9" "642.8" "584.2" "522.8" "654.5" "1778.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7834140751544997544" "False" "High" "IsMasterProtein" "Q7Z6Z7" "E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens OX=9606 GN=HUWE1 PE=1 SV=3" "0.000" "False" "52.633" "4" "16" "18" "16" "4374" "481.6" "5.22" "46.09" "16" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00627, Pf00632, Pf02825, Pf06012, Pf06025, Pf14377" "10075" "ENSG00000086758" "HUWE1" "hsa:10075; O15029; Q4G2Z2; Q5H961; Q6P4D0; Q7Z6Z7; Q8NG67; Q9BUI0; Q9HCJ4; Q9NSL6; Q9P0A9" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation" "2" "0" "1.193" "1.088" "1.210" "1.256" "1.235" "1.221" "0.924" "1.138" "3.859" "361.3" "430.8" "393.0" "437.1" "453.6" "446.1" "441.1" "333.9" "411.0" "1394.1" "" "" "" "" "" "" "" "" "" "" "216.2" "223.9" "217.7" "205.2" "210.2" "228.3" "205.1" "149.9" "223.0" "1394.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "692688187917917011" "False" "High" "IsMasterProtein" "P82979" "SAP domain-containing ribonucleoprotein OS=Homo sapiens OX=9606 GN=SARNP PE=1 SV=3" "0.000" "False" "52.413" "35" "7" "57" "7" "210" "23.7" "6.42" "162.81" "7" "other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037" "84324" "ENSG00000205323" "SARNP" "A8K393; hsa:84324; P82979; Q9P066" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "0.942" "0.890" "0.934" "0.945" "0.909" "1.082" "1.009" "0.863" "0.490" "4140.6" "3901.8" "3686.8" "3867.3" "3911.3" "3765.8" "4479.3" "4177.3" "3572.0" "2027.6" "" "" "" "" "" "" "" "" "" "" "2477.9" "2027.6" "2041.7" "1815.6" "1813.0" "1927.8" "2082.8" "1875.3" "1938.0" "2027.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7273803465605434037" "False" "High" "IsMasterProtein" "P05455" "Lupus La protein OS=Homo sapiens OX=9606 GN=SSB PE=1 SV=2" "0.000" "False" "52.380" "30" "12" "35" "12" "408" "46.8" "7.12" "79.12" "12" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf05383, Pf08777" "6741" "ENSG00000138385" "SSB" "hsa:6741; P05455; Q15367; Q53XJ4" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination" "2" "0" "1.024" "1.152" "0.978" "1.086" "0.959" "0.870" "0.798" "0.908" "1.905" "1802.9" "1846.8" "2077.3" "1763.5" "1957.3" "1729.6" "1568.8" "1439.5" "1637.2" "3434.2" "" "" "" "" "" "" "" "" "" "" "1078.9" "959.7" "1150.4" "827.9" "907.2" "885.4" "729.5" "646.2" "888.2" "3434.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2458252490920426752" "False" "High" "IsMasterProtein" "P16402" "Histone H1.3 OS=Homo sapiens OX=9606 GN=H1-3 PE=1 SV=2" "0.000" "False" "51.892" "31" "8" "60" "1" "221" "22.3" "11.02" "168.47" "8" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3007" "ENSG00000124575" "H1-3" "B2R751; hsa:3007; P16402; Q2M2I2" "" "Formation of Senescence-Associated Heterochromatin Foci (SAHF); Apoptosis induced DNA fragmentation" "2" "5" "0.970" "0.948" "0.744" "0.840" "0.857" "0.688" "0.707" "0.696" "0.593" "8893.9" "8629.1" "8431.9" "6615.8" "7471.6" "7619.1" "6121.1" "6284.0" "6186.6" "5272.8" "" "" "" "" "" "" "" "" "" "" "5322.5" "4484.2" "4669.4" "3105.9" "3463.2" "3900.4" "2846.2" "2821.1" "3356.5" "5272.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8135854214922228039" "False" "High" "IsMasterProtein" "Q9BY44" "Eukaryotic translation initiation factor 2A OS=Homo sapiens OX=9606 GN=EIF2A PE=1 SV=3" "0.000" "False" "51.847" "24" "13" "39" "13" "585" "64.9" "8.87" "90.11" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity" "Pf08662" "83939" "ENSG00000144895" "EIF2A" "A8MPS6; B4DF96; B4DQ14; D3DNI9; hsa:83939; Q5QTR2; Q7Z4E9; Q8NFM1; Q96EW9; Q96K81; Q9BY44" "Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome" "" "3" "0" "1.025" "1.046" "1.034" "1.080" "1.094" "0.983" "0.962" "1.051" "1.272" "1887.6" "1934.6" "1973.7" "1951.3" "2039.2" "2065.8" "1855.6" "1815.9" "1984.6" "2401.7" "" "" "" "" "" "" "" "" "" "" "1129.6" "1005.3" "1093.0" "916.1" "945.2" "1057.5" "862.8" "815.2" "1076.7" "2401.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7662049170687489427" "False" "High" "IsMasterProtein" "Q9Y376" "Calcium-binding protein 39 OS=Homo sapiens OX=9606 GN=CAB39 PE=1 SV=1" "0.000" "False" "51.770" "39" "15" "36" "13" "341" "39.8" "6.89" "97.07" "15" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf08569" "51719" "ENSG00000135932" "CAB39" "A8K8L7; hsa:51719; Q9Y376" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias" "Neutrophil degranulation; Energy dependent regulation of mTOR by LKB1-AMPK" "6" "2" "1.039" "1.049" "0.992" "0.967" "1.105" "0.904" "1.085" "1.015" "0.618" "2002.8" "2080.7" "2100.1" "1987.3" "1937.0" "2213.6" "1810.6" "2173.4" "2031.9" "1237.2" "" "" "" "" "" "" "" "" "" "" "1198.5" "1081.2" "1163.0" "933.0" "897.9" "1133.2" "841.9" "975.7" "1102.4" "1237.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4267649636453152821" "False" "High" "IsMasterProtein" "P16949" "Stathmin OS=Homo sapiens OX=9606 GN=STMN1 PE=1 SV=3" "0.000" "False" "51.754" "53" "10" "133" "9" "149" "17.3" "5.97" "296.25" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00836" "3925" "ENSG00000117632" "STMN1" "A2A2D1; B2R4E7; B7Z8N4; D3DPJ5; hsa:3925; P16949" "Microtubule cytoskeleton regulation; Retinoblastoma gene in cancer; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; IL-18 signaling pathway" "Nuclear signaling by ERBB4" "7" "1" "0.963" "0.924" "0.943" "1.002" "0.986" "1.016" "1.082" "0.891" "0.415" "5666.4" "5455.4" "5233.3" "5345.6" "5679.3" "5585.1" "5755.2" "6129.1" "5050.8" "2353.7" "" "" "" "" "" "" "" "" "" "" "3391.0" "2835.0" "2898.1" "2509.6" "2632.5" "2859.2" "2676.0" "2751.6" "2740.3" "2353.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5365621191326057651" "False" "High" "IsMasterProtein" "P54819" "Adenylate kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=AK2 PE=1 SV=2" "0.000" "False" "51.609" "51" "11" "42" "11" "239" "26.5" "7.81" "108.61" "11" "other metabolic processes" "cytoskeleton;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "204" "ENSG00000004455" "AK2" "A8K6L1; B4DHH7; B4DL64; hsa:204; P54819; Q16856; Q5EB54; Q5TIF7; Q8TCY2; Q8TCY3" "" "Interconversion of nucleotide di- and triphosphates" "1" "0" "0.984" "0.940" "0.964" "0.952" "0.885" "0.997" "0.881" "0.946" "0.641" "2558.6" "2517.4" "2404.0" "2467.6" "2435.3" "2265.3" "2551.4" "2253.3" "2421.7" "1639.5" "" "" "" "" "" "" "" "" "" "" "1531.2" "1308.2" "1331.3" "1158.5" "1128.8" "1159.7" "1186.4" "1011.6" "1313.9" "1639.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1447147241946060131" "False" "High" "IsMasterProtein" "P61604" "10 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPE1 PE=1 SV=2" "0.000" "False" "51.358" "79" "10" "125" "10" "102" "10.9" "8.92" "315.99" "10" "protein metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf00166" "3336" "ENSG00000115541" "HSPE1" "hsa:3336; O95421; P61604; Q04984; Q53X54; Q9UDH0" "" "RHOG GTPase cycle" "1" "0" "0.837" "0.827" "0.818" "0.875" "0.843" "0.895" "0.913" "0.767" "0.377" "14279.4" "11951.9" "11812.5" "11673.4" "12496.2" "12035.4" "12783.9" "13040.0" "10945.4" "5387.5" "" "" "" "" "" "" "" "" "" "" "8545.4" "6210.9" "6541.5" "5480.4" "5792.2" "6161.2" "5944.2" "5854.2" "5938.3" "5387.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5778599060552415361" "False" "High" "IsMasterProtein" "P52272" "Heterogeneous nuclear ribonucleoprotein M OS=Homo sapiens OX=9606 GN=HNRNPM PE=1 SV=3" "0.000" "False" "51.128" "22" "15" "20" "15" "730" "77.5" "8.70" "49.92" "15" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11532" "4670" "ENSG00000099783" "HNRNPM" "hsa:4670; P52272; Q15584; Q8WZ44; Q96H56; Q9BWL9; Q9Y492" "mRNA processing" "Processing of Capped Intron-Containing Pre-mRNA; mRNA Splicing - Major Pathway; FGFR2 alternative splicing" "4" "0" "0.955" "1.081" "1.038" "0.995" "1.067" "1.038" "0.109" "1.069" "14.178" "359.8" "343.7" "389.1" "373.6" "358.2" "384.1" "373.6" "39.4" "384.8" "5102.0" "" "" "" "" "" "" "" "" "" "" "215.3" "178.6" "215.5" "175.4" "166.0" "196.6" "173.7" "17.7" "208.8" "5102.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6201262043542307507" "False" "High" "IsMasterProtein" "P34896" "Serine hydroxymethyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=SHMT1 PE=1 SV=1" "0.000" "False" "51.097" "27" "11" "39" "10" "483" "53.0" "7.71" "88.52" "11" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00464" "6470" "ENSG00000176974; ENSG00000284320" "SHMT1" "B4DPM9; D3DXD0; hsa:6470; P34896; Q96HY0; Q9UMD1; Q9UMD2" "Glycine metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Male infertility; Neuroinflammation and glutamatergic signaling; Spina bifida; Metabolic Epileptic Disorders; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Metabolism of folate and pterines; Carnitine synthesis" "13" "0" "1.010" "1.028" "0.964" "0.998" "0.967" "1.035" "1.015" "1.056" "0.677" "1722.1" "1739.3" "1770.4" "1659.6" "1718.1" "1664.6" "1782.9" "1747.1" "1818.5" "1165.3" "" "" "" "" "" "" "" "" "" "" "1030.6" "903.9" "980.4" "779.2" "796.4" "852.2" "829.0" "784.4" "986.6" "1165.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7630142415015692295" "False" "High" "IsMasterProtein" "P14314" "Glucosidase 2 subunit beta OS=Homo sapiens OX=9606 GN=PRKCSH PE=1 SV=2" "0.000" "False" "50.843" "19" "9" "24" "9" "528" "59.4" "4.41" "68.09" "9" "protein metabolism;other metabolic processes;developmental processes;signal transduction" "ER/Golgi;other cell component" "other molecular function" "Pf12999, Pf13015, Pf13202" "5589" "ENSG00000130175" "PRKCSH" "A8K318; hsa:5589; P14314; Q96BU9; Q96D06; Q9P0W9" "" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Advanced glycosylation endproduct receptor signaling; Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "7" "0" "0.994" "0.976" "0.965" "1.082" "0.974" "1.082" "1.002" "1.017" "0.943" "1392.4" "1384.7" "1358.5" "1343.3" "1506.4" "1355.8" "1506.9" "1395.3" "1416.1" "1312.6" "" "" "" "" "" "" "" "" "" "" "833.3" "719.6" "752.3" "630.6" "698.2" "694.1" "700.7" "626.4" "768.3" "1312.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2100681429736934038" "False" "High" "IsMasterProtein" "O95218" "Zinc finger Ran-binding domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZRANB2 PE=1 SV=2" "0.000" "False" "50.777" "28" "9" "22" "9" "330" "37.4" "10.01" "59.29" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00641" "9406" "ENSG00000132485" "ZRANB2" "D3DQ75; hsa:9406; O95218; Q53GS3; Q59F92; Q5VV33; Q5VV34; Q8IXN6; Q9UP63" "" "" "0" "0" "0.935" "0.882" "0.941" "1.122" "1.137" "0.991" "0.897" "0.907" "0.383" "843.2" "788.3" "743.8" "793.3" "946.4" "959.1" "835.2" "756.6" "765.2" "323.2" "" "" "" "" "" "" "" "" "" "" "504.6" "409.7" "411.9" "372.4" "438.7" "491.0" "388.4" "339.6" "415.1" "323.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3827413943900730422" "False" "High" "IsMasterProtein" "Q9Y2W2" "WW domain-binding protein 11 OS=Homo sapiens OX=9606 GN=WBP11 PE=1 SV=1" "0.000" "False" "50.612" "20" "12" "26" "12" "641" "70.0" "8.38" "62.69" "12" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09429" "51729" "ENSG00000084463" "WBP11" "hsa:51729; Q96AY8; Q9Y2W2" "" "mRNA Splicing - Major Pathway" "1" "0" "1.036" "1.051" "1.002" "1.089" "0.990" "1.043" "1.027" "0.996" "0.643" "1324.5" "1372.2" "1391.5" "1326.7" "1442.4" "1311.5" "1381.4" "1359.9" "1318.9" "851.0" "" "" "" "" "" "" "" "" "" "" "792.6" "713.1" "770.6" "622.9" "668.6" "671.4" "642.3" "610.5" "715.6" "851.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4877503792566385355" "False" "High" "IsMasterProtein" "O75822" "Eukaryotic translation initiation factor 3 subunit J OS=Homo sapiens OX=9606 GN=EIF3J PE=1 SV=2" "0.000" "False" "50.554" "44" "11" "21" "11" "258" "29.0" "4.83" "63.31" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08597" "8669" "ENSG00000104131" "EIF3J" "B4DUI3; F5H425; hsa:8669; O75822; Q9BUD2; Q9H8Q2; Q9UI65" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "1.154" "1.027" "1.003" "1.156" "1.043" "1.259" "1.215" "1.140" "0.624" "844.4" "974.3" "867.0" "847.0" "976.4" "881.0" "1063.1" "1026.1" "962.5" "526.6" "" "" "" "" "" "" "" "" "" "" "505.3" "506.3" "480.1" "397.7" "452.6" "451.0" "494.3" "460.7" "522.2" "526.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8705476780399299386" "False" "High" "IsMasterProtein" "P46940" "Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens OX=9606 GN=IQGAP1 PE=1 SV=1" "0.000" "False" "50.472" "9" "14" "22" "14" "1657" "189.1" "6.48" "49.72" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00307, Pf00612, Pf00616, Pf03836" "8826" "ENSG00000140575" "IQGAP1" "A7MBM3; hsa:8826; P46940" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; Ciliary landscape; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "Neutrophil degranulation; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; RHOQ GTPase cycle; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RHOV GTPase cycle; Signaling by BRAF and RAF1 fusions; RHOU GTPase cycle; Nephrin family interactions; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "25" "0" "1.063" "1.112" "1.106" "1.210" "1.089" "1.053" "0.728" "1.207" "5.364" "578.8" "615.0" "643.6" "640.0" "700.3" "630.3" "609.7" "421.2" "698.8" "3104.7" "" "" "" "" "" "" "" "" "" "" "346.4" "319.6" "356.4" "300.5" "324.6" "322.7" "283.5" "189.1" "379.1" "3104.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4137666002023082164" "False" "High" "IsMasterProtein" "Cont_P00761" "Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1" "0.000" "True" "50.233" "39" "6" "169" "6" "231" "24.4" "7.18" "433.29" "6" "protein metabolism;other biological processes" "non-structural extracellular" "other molecular function" "Pf00089" "" "" "" "" "" "" "0" "0" "1.052" "0.981" "1.034" "1.189" "1.164" "1.187" "1.283" "1.069" "0.768" "8499.3" "8940.2" "8340.1" "8789.8" "10105.0" "9894.7" "10091.9" "10908.0" "9089.6" "6528.7" "" "" "" "" "" "" "" "" "" "" "5086.4" "4645.9" "4618.6" "4126.6" "4683.8" "5065.3" "4692.5" "4897.1" "4931.5" "6528.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2160825122742080574" "False" "High" "IsMasterProtein" "Q13162" "Peroxiredoxin-4 OS=Homo sapiens OX=9606 GN=PRDX4 PE=1 SV=1" "0.000" "False" "50.148" "35" "10" "63" "7" "271" "30.5" "6.29" "167.04" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00578, Pf10417" "10549" "ENSG00000123131" "PRDX4" "hsa:10549; Q13162; Q6FHT3" "Selenium micronutrient network" "Neutrophil degranulation" "2" "3" "1.017" "0.997" "1.020" "1.024" "0.966" "1.038" "1.080" "1.006" "0.656" "3968.7" "4035.8" "3956.0" "4046.9" "4064.9" "3833.5" "4119.2" "4286.7" "3993.5" "2604.4" "" "" "" "" "" "" "" "" "" "" "2375.1" "2097.3" "2190.8" "1899.9" "1884.2" "1962.5" "1915.4" "1924.5" "2166.7" "2604.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4844416647535235754" "False" "High" "IsMasterProtein" "O00233" "26S proteasome non-ATPase regulatory subunit 9 OS=Homo sapiens OX=9606 GN=PSMD9 PE=1 SV=3" "0.000" "False" "50.101" "38" "9" "24" "9" "223" "24.7" "6.95" "66.79" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf17820, Pf18265" "5715" "ENSG00000110801" "PSMD9" "B2RD35; G3V1Q6; hsa:5715; O00233; Q9BQ42" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "0.966" "0.995" "0.984" "1.005" "0.980" "0.981" "1.013" "0.881" "0.489" "1720.4" "1661.2" "1711.6" "1693.1" "1729.2" "1685.6" "1687.4" "1743.0" "1515.9" "841.6" "" "" "" "" "" "" "" "" "" "" "1029.6" "863.2" "947.8" "794.8" "801.5" "862.9" "784.6" "782.5" "822.5" "841.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7405730642826192701" "False" "High" "IsMasterProtein" "P00390" "Glutathione reductase, mitochondrial OS=Homo sapiens OX=9606 GN=GSR PE=1 SV=2" "0.000" "False" "50.023" "22" "9" "41" "9" "522" "56.2" "8.50" "117.82" "9" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf00070, Pf02852" "2936" "ENSG00000104687" "GSR" "C8KIL8; C8KIL9; C8KIM0; D3DSV3; hsa:2936; P00390; Q7Z5C9; Q9NP63" "Glutathione metabolism; Selenium micronutrient network; Trans-sulfuration, one-carbon metabolism and related pathways; Nuclear receptors meta-pathway; NRF2 pathway; Amino acid metabolism; One-carbon metabolism and related pathways; Oxidative stress response; Vitamin D-sensitive calcium signaling in depression; Sulfation biotransformation reaction; Metapathway biotransformation Phase I and II" "" "11" "0" "1.027" "0.964" "1.022" "0.960" "0.903" "1.150" "1.004" "1.075" "0.575" "1646.4" "1691.0" "1587.3" "1682.1" "1579.9" "1486.2" "1892.9" "1653.4" "1770.1" "947.3" "" "" "" "" "" "" "" "" "" "" "985.3" "878.8" "879.0" "789.7" "732.3" "760.8" "880.2" "742.3" "960.3" "947.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6421674880825804013" "False" "High" "IsMasterProtein" "Q96C19" "EF-hand domain-containing protein D2 OS=Homo sapiens OX=9606 GN=EFHD2 PE=1 SV=1" "0.000" "False" "49.953" "35" "8" "20" "8" "240" "26.7" "5.20" "58.47" "8" "" "other membranes" "other molecular function" "Pf21008" "79180" "ENSG00000142634" "EFHD2" "hsa:79180; Q5JYW9; Q96C19" "" "RHOD GTPase cycle" "1" "0" "1.132" "1.074" "1.036" "1.137" "1.074" "1.180" "1.094" "1.081" "1.177" "873.4" "988.9" "937.8" "905.0" "993.4" "938.3" "1030.8" "955.4" "943.9" "1027.5" "" "" "" "" "" "" "" "" "" "" "522.7" "513.9" "519.3" "424.9" "460.4" "480.4" "479.3" "428.9" "512.1" "1027.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6101173507286650100" "False" "High" "IsMasterProtein" "O43852" "Calumenin OS=Homo sapiens OX=9606 GN=CALU PE=1 SV=2" "0.000" "False" "49.785" "40" "10" "18" "10" "315" "37.1" "4.64" "56.81" "10" "" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf13202" "813" "ENSG00000128595" "CALU" "B3KPG9; D6QS48; D6QS49; D6QS50; D6QS51; D6QS52; D6QS53; D6QS54; D6QS55; D6QS56; D6QS57; D6QS58; D6QS59; F5H1Q9; F5H879; hsa:813; O43852; O60456; Q6FHB9; Q96RL3; Q9NR43" "NOTCH1 regulation of endothelial cell calcification; VEGFA-VEGFR2 signaling" "Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "5" "0" "0.913" "0.870" "0.888" "0.882" "0.876" "1.088" "1.047" "0.937" "0.655" "1651.3" "1508.0" "1436.5" "1466.3" "1455.8" "1447.0" "1795.8" "1729.7" "1547.5" "1082.2" "" "" "" "" "" "" "" "" "" "" "988.2" "783.6" "795.5" "688.4" "674.8" "740.7" "835.0" "776.5" "839.6" "1082.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-165801227635855458" "False" "High" "IsMasterProtein" "Q00839" "Heterogeneous nuclear ribonucleoprotein U OS=Homo sapiens OX=9606 GN=HNRNPU PE=1 SV=6" "0.000" "False" "49.689" "13" "9" "39" "9" "825" "90.5" "6.00" "100.56" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00622, Pf02037, Pf13671" "3192" "ENSG00000153187" "HNRNPU" "hsa:3192; O75507; Q00839; Q8N174; Q96HY9; Q9BQ09" "mRNA processing; lncRNA in canonical Wnt signaling and colorectal cancer" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "4" "0" "1.034" "1.082" "1.097" "1.054" "1.170" "1.022" "0.595" "1.096" "6.514" "1094.5" "1131.7" "1184.0" "1200.1" "1153.6" "1280.1" "1118.4" "651.0" "1199.7" "7129.3" "" "" "" "" "" "" "" "" "" "" "655.0" "588.1" "655.7" "563.4" "534.7" "655.3" "520.0" "292.2" "650.9" "7129.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "152076562272560972" "False" "High" "IsMasterProtein" "Q13409" "Cytoplasmic dynein 1 intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1I2 PE=1 SV=3" "0.000" "False" "49.657" "15" "7" "12" "7" "638" "71.4" "5.20" "39.07" "7" "transport;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf11540" "1781" "ENSG00000077380; ENSG00000292102" "DYNC1I2" "B7ZA04; D3DPD4; D3DPD5; D3DPD6; hsa:1781; Q13409; Q32LY9; Q53S84; Q5BJF8; Q7Z4X1; Q96NG7; Q96S87; Q9BXZ5; Q9NT58" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption; HDAC6 interactions in the central nervous system" "HCMV Early Events; Separation of Sister Chromatids; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; MHC class II antigen presentation; RHO GTPases Activate Formins; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "23" "0" "1.025" "0.942" "0.920" "0.959" "0.836" "0.988" "0.953" "0.879" "0.933" "578.3" "592.8" "544.5" "532.3" "554.8" "483.6" "571.3" "551.2" "508.3" "539.7" "" "" "" "" "" "" "" "" "" "" "346.1" "308.1" "301.5" "249.9" "257.2" "247.6" "265.6" "247.5" "275.8" "539.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7405227159340641842" "False" "High" "IsMasterProtein" "P62195" "26S proteasome regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMC5 PE=1 SV=1" "0.000" "False" "49.502" "39" "13" "38" "12" "406" "45.6" "7.55" "88.52" "13" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00004, Pf16450, Pf17862" "5705" "ENSG00000087191" "PSMC5" "A8K3Z3; A8K763; hsa:5705; O35051; O43208; P47210; P52915; P52916; P62195" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Alzheimer's disease" "Regulation of expression of SLITs and ROBOs; UCH proteinases; Ub-specific processing proteases; Downstream TCR signaling; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "1" "1.000" "0.945" "1.093" "1.015" "1.054" "1.117" "1.050" "0.998" "0.738" "1102.0" "1101.7" "1041.6" "1205.1" "1118.9" "1161.1" "1230.8" "1156.8" "1100.2" "812.9" "" "" "" "" "" "" "" "" "" "" "659.5" "572.5" "576.8" "565.7" "518.6" "594.4" "572.3" "519.4" "596.9" "812.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2098807042560158640" "False" "High" "IsMasterProtein" "P13489" "Ribonuclease inhibitor OS=Homo sapiens OX=9606 GN=RNH1 PE=1 SV=2" "0.000" "False" "49.398" "22" "10" "21" "10" "461" "49.9" "4.82" "55.90" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf13516, Pf18779" "6050" "ENSG00000023191; ENSG00000276230" "RNH1" "hsa:6050; P13489; Q8IZK8; Q96FD7; Q9BQ80; Q9UDK6" "" "" "0" "0" "1.093" "1.028" "1.098" "1.105" "1.047" "1.029" "1.055" "1.062" "1.505" "802.3" "876.7" "825.0" "880.7" "886.7" "840.4" "825.8" "846.3" "852.3" "1207.2" "" "" "" "" "" "" "" "" "" "" "480.2" "455.6" "456.9" "413.5" "411.0" "430.2" "384.0" "379.9" "462.4" "1207.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8479889696518381262" "False" "High" "IsMasterProtein" "P37802" "Transgelin-2 OS=Homo sapiens OX=9606 GN=TAGLN2 PE=1 SV=3" "0.000" "False" "49.229" "56" "11" "81" "11" "199" "22.4" "8.25" "165.10" "11" "cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton" "cytoskeletal activity" "Pf00307, Pf00402" "8407" "ENSG00000158710" "TAGLN2" "E9KL39; hsa:8407; P37802; Q5JRQ6; Q5JRQ7; Q6FGI1; Q9BUH5; Q9H4P0" "" "Platelet degranulation" "1" "0" "1.065" "1.157" "1.077" "1.078" "1.020" "1.139" "0.972" "1.065" "1.740" "4925.3" "5246.5" "5697.3" "5305.9" "5310.1" "5023.1" "5611.8" "4788.3" "5243.1" "8569.0" "" "" "" "" "" "" "" "" "" "" "2947.5" "2726.4" "3155.0" "2491.0" "2461.3" "2571.5" "2609.4" "2149.6" "2844.6" "8569.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7312941423538826307" "False" "High" "IsMasterProtein" "P31350" "Ribonucleoside-diphosphate reductase subunit M2 OS=Homo sapiens OX=9606 GN=RRM2 PE=1 SV=1" "0.000" "False" "49.224" "27" "10" "31" "8" "389" "44.8" "5.38" "74.72" "10" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00268" "6241" "ENSG00000171848" "RRM2" "B2R9B5; hsa:6241; J3KP43; P31350; Q5WRU7" "Fluoropyrimidine activity; Retinoblastoma gene in cancer; Hepatitis C and hepatocellular carcinoma; Pyrimidine metabolism; Orexin receptor pathway" "Transcriptional Regulation by E2F6; Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription" "8" "1" "0.982" "0.973" "1.167" "1.075" "1.095" "1.482" "1.579" "1.421" "0.859" "804.2" "789.8" "782.6" "938.2" "864.5" "880.7" "1191.8" "1269.7" "1142.8" "690.6" "" "" "" "" "" "" "" "" "" "" "481.3" "410.4" "433.4" "440.5" "400.7" "450.8" "554.2" "570.0" "620.0" "690.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-877235499680530927" "False" "High" "IsMasterProtein" "Q15366" "Poly(rC)-binding protein 2 OS=Homo sapiens OX=9606 GN=PCBP2 PE=1 SV=1" "0.000" "False" "49.215" "29" "8" "36" "4" "365" "38.6" "6.79" "84.41" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "5094" "ENSG00000197111" "PCBP2" "A8K7X6; B4DXP5; F8VYL7; G3V0E8; hsa:5094; I6L8F9; Q15366; Q32Q82; Q59HD4; Q68Y55; Q6IPF4; Q6PKG5" "mRNA processing; Ferroptosis; Modulators of TCR signaling and T cell activation" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; Negative regulators of DDX58/IFIH1 signaling; SARS-CoV-1 activates/modulates innate immune responses" "7" "0" "1.126" "1.365" "1.161" "1.188" "1.227" "1.312" "0.952" "1.063" "4.738" "248.8" "280.2" "339.5" "288.9" "295.7" "305.3" "326.3" "236.7" "264.5" "1178.7" "" "" "" "" "" "" "" "" "" "" "148.9" "145.6" "188.0" "135.6" "137.0" "156.3" "151.7" "106.3" "143.5" "1178.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "197200824509217859" "False" "High" "IsMasterProtein" "P31040" "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHA PE=1 SV=2" "0.000" "False" "49.194" "22" "12" "17" "12" "664" "72.6" "7.39" "40.44" "12" "other metabolic processes;developmental processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00890, Pf02910" "6389" "ENSG00000073578" "SDHA" "A8K5J6; B4DJ60; E9PBJ5; hsa:6389; P31040; Q16395; Q59GW8; Q8IW48; Q9UMY5" "Electron transport chain: OXPHOS system in mitochondria; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; Arsenic metabolism and reactive oxygen species generation; TCA cycle (aka Krebs or citric acid cycle)" "Respiratory electron transport; Citric acid cycle (TCA cycle)" "9" "0" "1.001" "1.019" "0.907" "0.909" "0.994" "1.031" "0.978" "1.019" "0.701" "1126.6" "1127.2" "1148.3" "1021.3" "1023.6" "1119.9" "1161.0" "1101.7" "1148.5" "790.0" "" "" "" "" "" "" "" "" "" "" "674.2" "585.8" "635.9" "479.5" "474.5" "573.3" "539.8" "494.6" "623.1" "790.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2641060010654775307" "False" "High" "IsMasterProtein" "O00232" "26S proteasome non-ATPase regulatory subunit 12 OS=Homo sapiens OX=9606 GN=PSMD12 PE=1 SV=3" "0.000" "False" "49.072" "22" "10" "36" "10" "456" "52.9" "7.65" "83.83" "10" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01399, Pf18098" "5718" "ENSG00000197170" "PSMD12" "A6NP15; hsa:5718; O00232; Q53HA2; Q6P053" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "0.978" "0.993" "1.068" "0.957" "1.130" "1.012" "1.087" "0.950" "1.007" "1581.8" "1546.4" "1570.3" "1688.6" "1514.4" "1787.3" "1600.4" "1718.6" "1502.5" "1593.5" "" "" "" "" "" "" "" "" "" "" "946.6" "803.6" "869.6" "792.7" "701.9" "915.0" "744.1" "771.6" "815.2" "1593.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5335677543697524354" "False" "High" "IsMasterProtein" "P17844" "Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens OX=9606 GN=DDX5 PE=1 SV=1" "0.000" "False" "48.974" "20" "13" "26" "9" "614" "69.1" "8.92" "72.78" "13" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08061" "1655" "ENSG00000108654" "DDX5" "B4DLW8; B5BU21; D3DU32; E7ETL9; hsa:1655; O75681; P17844; Q53Y61" "Ciliary landscape" "mRNA Splicing - Major Pathway; SUMOylation of transcription cofactors; Estrogen-dependent gene expression; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome" "6" "3" "1.029" "1.052" "1.054" "1.089" "1.165" "0.980" "0.355" "1.157" "10.302" "496.3" "510.7" "521.8" "523.3" "540.2" "578.0" "486.5" "176.0" "574.3" "5112.6" "" "" "" "" "" "" "" "" "" "" "297.0" "265.4" "289.0" "245.7" "250.4" "295.9" "226.2" "79.0" "311.6" "5112.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "965270540937199853" "False" "High" "IsMasterProtein" "Q14151" "Scaffold attachment factor B2 OS=Homo sapiens OX=9606 GN=SAFB2 PE=1 SV=1" "0.000" "False" "48.953" "11" "10" "24" "5" "953" "107.4" "6.16" "61.28" "10" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02037" "9667" "ENSG00000130254" "SAFB2" "B4DKG3; hsa:9667; Q14151; Q8TB13" "" "" "0" "0" "0.989" "1.103" "1.019" "1.049" "0.933" "0.979" "1.284" "1.092" "0.609" "238.8" "236.3" "263.4" "243.4" "250.5" "222.8" "233.8" "306.7" "260.8" "145.3" "" "" "" "" "" "" "" "" "" "" "142.9" "122.8" "145.9" "114.2" "116.1" "114.1" "108.7" "137.7" "141.5" "145.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516272036315922492" "False" "High" "IsMasterProtein" "Q15637" "Splicing factor 1 OS=Homo sapiens OX=9606 GN=SF1 PE=1 SV=4" "0.000" "False" "48.780" "19" "10" "34" "10" "639" "68.3" "8.98" "82.09" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00098, Pf16275" "7536" "ENSG00000168066" "SF1" "B7Z1Q1; C9JJE2; hsa:7536; Q14818; Q14819; Q15637; Q15913; Q8IY00; Q92744; Q92745; Q969H7; Q9BW01; Q9UEI0" "" "mRNA Splicing - Major Pathway" "1" "0" "1.116" "1.053" "1.045" "1.056" "0.988" "1.060" "1.086" "0.995" "0.768" "1614.7" "1802.4" "1701.0" "1688.0" "1705.0" "1594.6" "1711.5" "1754.0" "1607.3" "1239.7" "" "" "" "" "" "" "" "" "" "" "966.3" "936.6" "942.0" "792.5" "790.3" "816.3" "795.8" "787.4" "872.0" "1239.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8621700409293052339" "False" "High" "IsMasterProtein" "P23368" "NAD-dependent malic enzyme, mitochondrial OS=Homo sapiens OX=9606 GN=ME2 PE=1 SV=1" "0.000" "False" "48.553" "21" "11" "34" "11" "584" "65.4" "7.61" "90.16" "11" "other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00390, Pf03949" "4200" "ENSG00000082212" "ME2" "B2R8J2; hsa:4200; P23368; Q9BWL6; Q9BYG1; Q9H4B2" "TCA cycle in senescence" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "3" "0" "0.957" "0.958" "1.048" "0.973" "1.078" "0.891" "0.956" "0.964" "1.049" "2141.3" "2050.3" "2051.3" "2243.3" "2084.4" "2308.3" "1908.9" "2047.6" "2063.7" "2246.7" "" "" "" "" "" "" "" "" "" "" "1281.4" "1065.4" "1136.0" "1053.2" "966.2" "1181.7" "887.6" "919.2" "1119.7" "2246.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-478504765432675351" "False" "High" "IsMasterProtein" "P30520" "Adenylosuccinate synthetase isozyme 2 OS=Homo sapiens OX=9606 GN=ADSS2 PE=1 SV=3" "0.000" "False" "48.536" "22" "9" "19" "9" "456" "50.1" "6.55" "63.60" "9" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00709" "159" "ENSG00000035687" "ADSS2" "B1AQM5; hsa:159; P30520; Q96EG7" "" "Purine ribonucleoside monophosphate biosynthesis" "1" "0" "0.964" "1.035" "0.913" "0.911" "1.006" "0.865" "1.030" "0.992" "0.575" "1998.1" "1927.1" "2068.3" "1825.1" "1820.3" "2009.3" "1728.7" "2057.3" "1981.8" "1149.3" "" "" "" "" "" "" "" "" "" "" "1195.8" "1001.4" "1145.4" "856.8" "843.8" "1028.6" "803.8" "923.6" "1075.2" "1149.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4516016884332694472" "False" "High" "IsMasterProtein" "O60361" "Putative nucleoside diphosphate kinase OS=Homo sapiens OX=9606 GN=NME2P1 PE=5 SV=1" "0.000" "False" "48.508" "53" "7" "69" "1" "137" "15.5" "8.57" "202.78" "7" "other metabolic processes;other biological processes" "" "kinase activity;other molecular function" "Pf00334" "" "" "NME2P1" "O60361" "" "Interconversion of nucleotide di- and triphosphates" "1" "0" "1.013" "1.097" "1.088" "1.048" "1.266" "0.933" "1.238" "1.038" "0.624" "571.4" "578.7" "626.8" "621.7" "598.7" "723.6" "533.0" "707.7" "592.9" "356.7" "" "" "" "" "" "" "" "" "" "" "342.0" "300.7" "347.1" "291.8" "277.5" "370.4" "247.8" "317.7" "321.7" "356.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8973265240341480372" "False" "High" "IsMasterProtein" "Q06203" "Amidophosphoribosyltransferase OS=Homo sapiens OX=9606 GN=PPAT PE=1 SV=1" "0.000" "False" "48.501" "22" "10" "33" "10" "517" "57.4" "6.76" "96.99" "10" "other metabolic processes" "cytosol" "other molecular function" "Pf00156, Pf13522" "5471" "ENSG00000128059" "PPAT" "hsa:5471; Q06203" "Fluoropyrimidine activity; Metabolic reprogramming in colon cancer" "Purine ribonucleoside monophosphate biosynthesis" "3" "0" "1.057" "1.054" "1.094" "1.006" "1.099" "0.933" "1.035" "1.033" "0.742" "1444.0" "1527.0" "1522.7" "1579.9" "1452.6" "1586.9" "1347.8" "1494.4" "1491.8" "1071.5" "" "" "" "" "" "" "" "" "" "" "864.2" "793.5" "843.2" "741.7" "673.3" "812.4" "626.7" "670.9" "809.4" "1071.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "185652229165611282" "False" "High" "IsMasterProtein" "Q9NY27" "Serine/threonine-protein phosphatase 4 regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PPP4R2 PE=1 SV=3" "0.000" "False" "48.481" "32" "7" "11" "7" "417" "46.9" "4.54" "35.47" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf09184" "151987" "ENSG00000163605" "PPP4R2" "A8K1I6; hsa:151987; Q2TAJ9; Q498B8; Q8WXX6; Q9NY27" "16p11.2 proximal deletion syndrome" "Processing of DNA double-strand break ends" "2" "0" "0.979" "1.052" "1.195" "1.340" "1.182" "0.991" "1.072" "0.850" "1.356" "131.3" "128.6" "138.2" "157.0" "176.1" "155.2" "130.2" "140.8" "111.6" "178.1" "" "" "" "" "" "" "" "" "" "" "78.6" "66.8" "76.5" "73.7" "81.6" "79.5" "60.5" "63.2" "60.6" "178.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3541019235990541605" "False" "High" "IsMasterProtein" "Q9UNM6" "26S proteasome non-ATPase regulatory subunit 13 OS=Homo sapiens OX=9606 GN=PSMD13 PE=1 SV=2" "0.000" "False" "48.308" "30" "13" "51" "13" "376" "42.9" "5.81" "139.35" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01399" "5719" "ENSG00000185627" "PSMD13" "B3KT15; hsa:5719; O75831; Q53XU2; Q9UNM6; Q9UNV3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Interleukin-1 signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "1.012" "0.928" "1.006" "0.980" "1.046" "0.982" "1.084" "0.980" "0.815" "4992.4" "5051.2" "4630.8" "5023.3" "4894.2" "5223.0" "4901.7" "5412.3" "4893.5" "4069.4" "" "" "" "" "" "" "" "" "" "" "2987.7" "2624.9" "2564.4" "2358.3" "2268.5" "2673.8" "2279.2" "2429.8" "2654.9" "4069.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3259999118554299265" "False" "High" "IsMasterProtein" "Q16181" "Septin-7 OS=Homo sapiens OX=9606 GN=SEPTIN7 PE=1 SV=2" "0.000" "False" "48.283" "25" "11" "35" "10" "437" "50.6" "8.63" "66.40" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00735" "989" "ENSG00000122545" "SEPTIN7" "hsa:989; Q16181; Q52M76; Q6NX50" "" "MAPK6/MAPK4 signaling" "1" "1" "0.997" "0.937" "1.084" "1.042" "0.968" "1.075" "0.968" "1.032" "0.781" "1702.3" "1696.9" "1594.8" "1844.5" "1773.4" "1648.2" "1830.5" "1648.2" "1756.4" "1329.7" "" "" "" "" "" "" "" "" "" "" "1018.7" "881.8" "883.2" "866.0" "822.0" "843.8" "851.2" "739.9" "952.9" "1329.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7904029165854268952" "False" "High" "IsMasterProtein" "P62191" "26S proteasome regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMC1 PE=1 SV=1" "0.000" "False" "48.119" "28" "12" "44" "11" "440" "49.2" "6.21" "118.82" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5700" "ENSG00000100764" "PSMC1" "B4DR63; hsa:5700; P49014; P62191; Q03527; Q6IAW0; Q6NW36; Q96AZ3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "64" "0" "1.015" "0.954" "1.022" "1.004" "1.043" "1.019" "1.038" "0.941" "0.777" "2362.7" "2398.3" "2253.5" "2414.6" "2372.1" "2463.2" "2408.6" "2452.1" "2222.8" "1834.9" "" "" "" "" "" "" "" "" "" "" "1414.0" "1246.3" "1247.9" "1133.6" "1099.5" "1261.0" "1119.9" "1100.8" "1205.9" "1834.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8112712839841425381" "False" "High" "IsMasterProtein" "Q8TAQ2" "SWI/SNF complex subunit SMARCC2 OS=Homo sapiens OX=9606 GN=SMARCC2 PE=1 SV=1" "0.000" "False" "48.072" "12" "14" "18" "10" "1214" "132.8" "5.69" "43.58" "14" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf04433, Pf16495, Pf16496, Pf16498" "6601" "ENSG00000139613" "SMARCC2" "F8VTJ5; hsa:6601; Q59GV3; Q8TAQ2; Q92923; Q96E12; Q96GY4" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome; 10q11.21q11.23 copy number variation syndrome" "RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "7" "1" "1.136" "1.029" "1.166" "1.110" "0.953" "1.178" "0.424" "1.093" "9.140" "124.2" "141.1" "127.8" "144.8" "137.9" "118.4" "146.3" "52.6" "135.8" "1135.1" "" "" "" "" "" "" "" "" "" "" "74.3" "73.3" "70.8" "68.0" "63.9" "60.6" "68.0" "23.6" "73.7" "1135.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4797790429512717329" "False" "High" "IsMasterProtein" "O75874" "Isocitrate dehydrogenase [NADP] cytoplasmic OS=Homo sapiens OX=9606 GN=IDH1 PE=1 SV=2" "0.000" "False" "48.022" "29" "12" "26" "11" "414" "46.6" "7.01" "70.27" "12" "other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00180" "3417" "ENSG00000138413" "IDH1" "hsa:3417; O75874; Q567U4; Q6FHQ6; Q7Z3V0; Q93090; Q9NTJ9; Q9UKW8" "Glutathione metabolism; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism" "Peroxisomal protein import; Neutrophil degranulation; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; NADPH regeneration; NFE2L2 regulating TCA cycle genes" "8" "1" "0.993" "0.926" "0.957" "0.914" "0.996" "1.034" "1.073" "0.967" "0.656" "1376.3" "1367.0" "1274.7" "1317.6" "1258.2" "1370.4" "1422.8" "1476.3" "1331.0" "902.2" "" "" "" "" "" "" "" "" "" "" "823.6" "710.4" "705.9" "618.6" "583.2" "701.6" "661.6" "662.8" "722.1" "902.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4520162396586865811" "False" "High" "IsMasterProtein" "P51148" "Ras-related protein Rab-5C OS=Homo sapiens OX=9606 GN=RAB5C PE=1 SV=2" "0.000" "False" "47.961" "48" "8" "23" "5" "216" "23.5" "8.41" "66.31" "8" "transport" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5878" "ENSG00000108774" "RAB5C" "F8W1H5; hsa:5878; P51148; Q6FH55; Q9P0Y5" "Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Vasopressin-regulated water reabsorption" "Neutrophil degranulation; RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Golgi Associated Vesicle Biogenesis; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; TBC/RABGAPs" "10" "3" "0.953" "0.949" "1.112" "0.950" "0.974" "1.031" "1.110" "1.029" "0.636" "600.2" "571.7" "569.4" "667.2" "570.3" "584.9" "618.8" "666.4" "617.3" "381.5" "" "" "" "" "" "" "" "" "" "" "359.2" "297.1" "315.3" "313.2" "264.3" "299.4" "287.7" "299.2" "334.9" "381.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "551881844425109656" "False" "High" "IsMasterProtein" "Q13573" "SNW domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SNW1 PE=1 SV=1" "0.000" "False" "47.802" "26" "13" "20" "13" "536" "61.5" "9.52" "47.12" "13" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf02731" "22938" "ENSG00000100603" "SNW1" "A8K8A9; hsa:22938; Q13483; Q13573; Q32N03; Q5D0D6" "TGF-beta signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Splicing factor NOVA regulated synaptic proteins; Notch signaling pathway" "mRNA Splicing - Major Pathway; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "16" "0" "1.067" "0.963" "0.982" "1.130" "1.015" "1.041" "1.087" "1.044" "0.707" "1006.7" "1073.9" "969.3" "989.0" "1137.4" "1021.5" "1047.5" "1093.9" "1051.0" "711.4" "" "" "" "" "" "" "" "" "" "" "602.4" "558.1" "536.8" "464.3" "527.2" "522.9" "487.1" "491.1" "570.2" "711.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2120449807322374936" "False" "High" "IsMasterProtein" "Q9Y2Z0" "Protein SGT1 homolog OS=Homo sapiens OX=9606 GN=SUGT1 PE=1 SV=3" "0.000" "False" "47.788" "31" "11" "21" "11" "365" "41.0" "5.16" "58.07" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04969, Pf05002" "10910" "ENSG00000165416" "SUGT1" "A2A303; hsa:10910; Q5JAK5; Q5TAM6; Q6VXY6; Q9Y2Z0" "Nucleotide-binding oligomerization domain (NOD) pathway" "The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection" "3" "0" "0.982" "0.988" "1.019" "1.020" "0.989" "1.068" "0.978" "1.089" "1.168" "814.5" "799.8" "804.4" "829.9" "830.6" "805.8" "869.7" "796.8" "886.7" "951.7" "" "" "" "" "" "" "" "" "" "" "487.4" "415.7" "445.4" "389.6" "385.0" "412.5" "404.4" "357.7" "481.1" "951.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4952006714438079555" "False" "High" "IsMasterProtein" "Q9Y4L1" "Hypoxia up-regulated protein 1 OS=Homo sapiens OX=9606 GN=HYOU1 PE=1 SV=1" "0.000" "False" "47.741" "15" "14" "26" "14" "999" "111.3" "5.22" "59.59" "14" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "other molecular function" "Pf00012" "10525" "ENSG00000149428; ENSG00000280682" "HYOU1" "A8C1Z0; B7Z909; hsa:10525; Q2I204; Q53H25; Q9Y4L1" "VEGFA-VEGFR2 signaling" "XBP1(S) activates chaperone genes; Scavenging by Class F Receptors" "3" "0" "1.026" "1.025" "1.042" "1.173" "1.058" "1.153" "0.932" "1.121" "3.340" "651.1" "667.7" "667.3" "678.6" "763.5" "688.6" "750.8" "606.6" "730.1" "2174.4" "" "" "" "" "" "" "" "" "" "" "389.6" "347.0" "369.5" "318.6" "353.9" "352.5" "349.1" "272.3" "396.1" "2174.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-294736394566280624" "False" "High" "IsMasterProtein" "Q16204" "Coiled-coil domain-containing protein 6 OS=Homo sapiens OX=9606 GN=CCDC6 PE=1 SV=2" "0.000" "False" "47.723" "26" "12" "29" "12" "474" "53.3" "7.34" "71.92" "12" "cell organization and biogenesis" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf09755" "8030" "ENSG00000108091" "CCDC6" "hsa:8030; Q15250; Q16204; Q6GSG7" "Retinoblastoma gene in cancer; Mesodermal commitment pathway; 16p11.2 proximal deletion syndrome" "" "3" "0" "1.008" "0.974" "1.039" "1.074" "0.959" "1.094" "1.023" "1.036" "0.921" "1706.0" "1719.2" "1661.0" "1772.1" "1832.4" "1635.7" "1867.0" "1746.0" "1767.9" "1571.3" "" "" "" "" "" "" "" "" "" "" "1020.9" "893.4" "919.8" "831.9" "849.3" "837.3" "868.1" "783.8" "959.2" "1571.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5004824679755995217" "False" "High" "IsMasterProtein" "Q13867" "Bleomycin hydrolase OS=Homo sapiens OX=9606 GN=BLMH PE=1 SV=1" "0.000" "False" "47.685" "25" "10" "57" "10" "455" "52.5" "6.27" "145.94" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf03051" "642" "ENSG00000108578" "BLMH" "B2R796; hsa:642; Q13867; Q53F86; Q9UER9" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.977" "1.065" "1.001" "1.046" "0.957" "1.023" "1.026" "1.042" "0.611" "2055.1" "2007.7" "2189.4" "2056.7" "2148.8" "1965.8" "2101.3" "2108.9" "2142.3" "1255.2" "" "" "" "" "" "" "" "" "" "" "1229.8" "1043.3" "1212.5" "965.6" "996.0" "1006.3" "977.1" "946.8" "1162.3" "1255.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2454508349601298395" "False" "High" "IsMasterProtein" "Q99447" "Ethanolamine-phosphate cytidylyltransferase OS=Homo sapiens OX=9606 GN=PCYT2 PE=1 SV=1" "0.000" "False" "47.484" "33" "13" "24" "13" "389" "43.8" "6.92" "53.95" "13" "other metabolic processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01467" "5833" "ENSG00000185813" "PCYT2" "B7Z7A5; B7ZAS0; F5H8B1; hsa:5833; Q6IBM3; Q96G08; Q99447" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids" "Synthesis of PE" "5" "0" "0.920" "0.936" "0.924" "0.973" "0.976" "0.943" "1.011" "1.006" "0.719" "944.9" "869.5" "884.0" "873.2" "919.5" "922.4" "890.6" "955.0" "950.8" "679.4" "" "" "" "" "" "" "" "" "" "" "565.5" "451.9" "489.6" "410.0" "426.2" "472.2" "414.1" "428.7" "515.9" "679.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6712994512663593747" "False" "High" "IsMasterProtein" "Q4G0N4" "NAD kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=NADK2 PE=1 SV=2" "0.000" "False" "47.474" "29" "12" "23" "12" "442" "49.4" "8.18" "56.77" "12" "other metabolic processes" "mitochondrion" "kinase activity;other molecular function" "Pf01513" "133686" "ENSG00000152620" "NADK2" "B5MC93; hsa:133686; Q4G0N4; Q6UTX5; Q96NM0" "" "Mitochondrial protein degradation; Nicotinate metabolism" "2" "0" "0.950" "0.923" "1.038" "0.938" "0.953" "0.960" "0.938" "0.954" "0.681" "1150.8" "1092.9" "1062.7" "1194.5" "1080.0" "1096.7" "1105.2" "1078.9" "1098.5" "784.2" "" "" "" "" "" "" "" "" "" "" "688.7" "567.9" "588.5" "560.8" "500.6" "561.4" "513.9" "484.4" "596.0" "784.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "906200433272310872" "False" "High" "IsMasterProtein" "Q8NBS9" "Thioredoxin domain-containing protein 5 OS=Homo sapiens OX=9606 GN=TXNDC5 PE=1 SV=2" "0.000" "False" "47.430" "28" "10" "22" "10" "432" "47.6" "5.97" "60.60" "10" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00085" "81567" "ENSG00000239264" "TXNDC5" "B2RDM2; hsa:81567; Q5TCQ0; Q8NBS9; Q8ND33; Q8TCT2; Q9BVH9" "VEGFA-VEGFR2 signaling" "Golgi Associated Vesicle Biogenesis; Neutrophil degranulation; Lysosome Vesicle Biogenesis" "4" "0" "1.017" "1.054" "1.026" "0.998" "0.976" "1.037" "1.113" "1.044" "0.583" "1384.3" "1408.0" "1459.0" "1420.0" "1382.1" "1351.5" "1435.9" "1540.5" "1444.7" "807.1" "" "" "" "" "" "" "" "" "" "" "828.4" "731.7" "807.9" "666.7" "640.6" "691.9" "667.6" "691.6" "783.8" "807.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6011940264998513028" "False" "High" "IsMasterProtein" "O00429" "Dynamin-1-like protein OS=Homo sapiens OX=9606 GN=DNM1L PE=1 SV=2" "0.000" "False" "47.302" "17" "12" "23" "12" "736" "81.8" "6.81" "57.76" "12" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00350, Pf01031, Pf02212" "10059" "ENSG00000087470" "DNM1L" "A8K4X9; B4DGC9; B4DSU8; G8JLD5; hsa:10059; J3KPI2; O00429; O14541; O60709; Q59GN9; Q7L6B3; Q8TBT7; Q9BWM1; Q9Y5J2" "Synaptic vesicle pathway; CAMKK2 pathway" "Apoptotic execution phase" "3" "0" "1.130" "0.924" "1.065" "1.196" "1.181" "1.026" "0.720" "0.999" "3.936" "575.4" "650.4" "531.7" "612.9" "688.3" "679.3" "590.2" "414.2" "574.6" "2264.8" "" "" "" "" "" "" "" "" "" "" "344.3" "338.0" "294.5" "287.7" "319.0" "347.8" "274.5" "186.0" "311.8" "2264.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1302469806401564563" "False" "High" "IsMasterProtein" "P49748" "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADVL PE=1 SV=1" "0.000" "False" "47.260" "20" "11" "16" "11" "655" "70.3" "8.75" "37.23" "11" "other metabolic processes;stress response;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00441, Pf02770, Pf02771, Pf21343" "37" "ENSG00000072778" "ACADVL" "B4DEB6; F5H2A9; hsa:37; O76056; P49748; Q8WUL0" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation" "XBP1(S) activates chaperone genes; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "4" "0" "1.065" "1.000" "1.118" "1.080" "1.035" "0.976" "1.060" "0.986" "0.820" "333.8" "355.5" "333.7" "373.2" "360.5" "345.5" "325.8" "353.7" "329.0" "273.8" "" "" "" "" "" "" "" "" "" "" "199.7" "184.7" "184.8" "175.2" "167.1" "176.8" "151.5" "158.8" "178.5" "273.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7971041458510100973" "False" "High" "IsMasterProtein" "P61201" "COP9 signalosome complex subunit 2 OS=Homo sapiens OX=9606 GN=COPS2 PE=1 SV=1" "0.000" "False" "47.127" "32" "13" "27" "13" "443" "51.6" "5.53" "56.70" "13" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01399" "9318" "ENSG00000166200" "COPS2" "hsa:9318; O88950; P61201; Q15647; Q6FGP4; Q9BY54; Q9R249; Q9UNI2; Q9UNQ5" "Ciliary landscape" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER" "6" "0" "1.047" "1.024" "1.026" "1.061" "1.127" "1.015" "1.090" "1.057" "0.761" "1441.9" "1509.6" "1476.5" "1479.7" "1530.1" "1625.1" "1463.2" "1571.3" "1524.8" "1097.0" "" "" "" "" "" "" "" "" "" "" "862.9" "784.5" "817.7" "694.7" "709.2" "831.9" "680.4" "705.4" "827.3" "1097.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8506961570143965113" "False" "High" "IsMasterProtein" "Q99497" "Parkinson disease protein 7 OS=Homo sapiens OX=9606 GN=PARK7 PE=1 SV=2" "0.000" "False" "47.111" "40" "9" "58" "9" "189" "19.9" "6.79" "168.37" "9" "cell-cell signaling;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01965" "11315" "ENSG00000116288" "PARK7" "B2R4Z1; hsa:11315; O14805; Q6DR95; Q7LFU2; Q99497" "Androgen receptor signaling pathway; Synaptic vesicle pathway; Parkinson's disease pathway; HDAC6 interactions in the central nervous system" "Late endosomal microautophagy; Aggrephagy; SUMOylation of transcription cofactors; Chaperone Mediated Autophagy" "8" "0" "0.985" "0.963" "1.014" "1.004" "0.967" "0.962" "1.010" "0.952" "0.539" "5288.3" "5210.3" "5090.1" "5363.5" "5307.9" "5115.5" "5085.1" "5343.1" "5034.9" "2852.1" "" "" "" "" "" "" "" "" "" "" "3164.8" "2707.6" "2818.8" "2518.0" "2460.3" "2618.8" "2364.5" "2398.7" "2731.7" "2852.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1037912225033679960" "False" "High" "IsMasterProtein" "P47756" "F-actin-capping protein subunit beta OS=Homo sapiens OX=9606 GN=CAPZB PE=1 SV=5" "0.000" "False" "47.085" "39" "10" "28" "10" "272" "30.6" "6.00" "62.67" "10" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01115" "832" "ENSG00000077549" "CAPZB" "hsa:832; P47756; Q32Q68; Q5U0L4; Q8TB49; Q9NUC4" "VEGFA-VEGFR2 signaling" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Sensory processing of sound by inner hair cells of the cochlea; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; RHOD GTPase cycle; RHOF GTPase cycle; Factors involved in megakaryocyte development and platelet production" "9" "0" "1.030" "1.115" "1.017" "0.939" "0.919" "1.007" "0.934" "1.082" "0.972" "1254.9" "1292.6" "1399.5" "1276.2" "1178.3" "1153.3" "1263.8" "1171.6" "1357.4" "1219.8" "" "" "" "" "" "" "" "" "" "" "751.0" "671.7" "775.0" "599.1" "546.2" "590.4" "587.6" "526.0" "736.4" "1219.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7263541365096533312" "False" "High" "IsMasterProtein" "Q13435" "Splicing factor 3B subunit 2 OS=Homo sapiens OX=9606 GN=SF3B2 PE=1 SV=2" "0.000" "False" "47.068" "14" "12" "19" "12" "895" "100.2" "5.67" "51.82" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02037, Pf04037, Pf04046" "10992" "ENSG00000087365" "SF3B2" "A8K485; B4DT19; hsa:10992; Q13435; Q7L4T5; Q7Z627; Q969K1; Q96CM6; Q9BWD2" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "1.029" "1.175" "0.998" "1.095" "1.032" "1.096" "1.059" "1.035" "1.155" "1572.4" "1618.5" "1848.3" "1568.6" "1721.9" "1622.8" "1723.7" "1664.8" "1628.1" "1816.7" "" "" "" "" "" "" "" "" "" "" "941.0" "841.1" "1023.5" "736.4" "798.1" "830.8" "801.5" "747.4" "883.3" "1816.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7309351128836490355" "False" "High" "IsMasterProtein" "P26583" "High mobility group protein B2 OS=Homo sapiens OX=9606 GN=HMGB2 PE=1 SV=2" "0.000" "False" "47.032" "43" "9" "36" "8" "209" "24.0" "7.81" "111.51" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "3148" "ENSG00000164104" "HMGB2" "B2R4K8; D3DP37; hsa:3148; P26583; Q5U072" "Retinoblastoma gene in cancer; Ectoderm differentiation; Ectoderm differentiation" "Apoptosis induced DNA fragmentation" "4" "1" "0.862" "0.804" "0.756" "0.896" "0.851" "0.786" "0.868" "0.795" "0.486" "2434.0" "2098.5" "1957.4" "1841.1" "2181.9" "2072.0" "1912.4" "2112.9" "1934.9" "1182.6" "" "" "" "" "" "" "" "" "" "" "1456.6" "1090.5" "1084.0" "864.3" "1011.3" "1060.7" "889.2" "948.6" "1049.8" "1182.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3220209801310809840" "False" "High" "IsMasterProtein" "P60891" "Ribose-phosphate pyrophosphokinase 1 OS=Homo sapiens OX=9606 GN=PRPS1 PE=1 SV=2" "0.000" "False" "46.819" "34" "10" "51" "6" "318" "34.8" "6.98" "145.29" "10" "other metabolic processes;developmental processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf13793, Pf14572" "5631" "ENSG00000147224" "PRPS1" "B1ALA8; B2R6T7; B4DNL6; D3DUX6; hsa:5631; P09329; P60891" "" "5-Phosphoribose 1-diphosphate biosynthesis" "1" "4" "0.969" "0.892" "0.975" "0.932" "0.979" "0.991" "1.006" "0.940" "0.631" "4352.6" "4217.1" "3883.6" "4242.8" "4054.8" "4263.0" "4315.0" "4380.5" "4092.5" "2745.8" "" "" "" "" "" "" "" "" "" "" "2604.8" "2191.5" "2150.7" "1991.9" "1879.5" "2182.3" "2006.4" "1966.6" "2220.4" "2745.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5135985212415519925" "False" "High" "IsMasterProtein" "P43686" "26S proteasome regulatory subunit 6B OS=Homo sapiens OX=9606 GN=PSMC4 PE=1 SV=2" "0.000" "False" "46.805" "29" "14" "34" "14" "418" "47.3" "5.21" "95.30" "14" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5704" "ENSG00000013275; ENSG00000281221" "PSMC4" "hsa:5704; P43686; Q96FV5; Q9UBM3; Q9UEX3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "Assembly of the pre-replicative complex; Neddylation; KEAP1-NFE2L2 pathway; Regulation of RAS by GAPs; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; Somitogenesis; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "0.968" "0.865" "1.052" "1.051" "1.069" "1.004" "1.063" "0.980" "0.805" "2245.3" "2172.7" "1942.4" "2362.4" "2360.1" "2400.8" "2253.7" "2387.7" "2199.9" "1808.6" "" "" "" "" "" "" "" "" "" "" "1343.7" "1129.1" "1075.6" "1109.1" "1094.0" "1229.0" "1047.9" "1071.9" "1193.5" "1808.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3249613255715037073" "False" "High" "IsMasterProtein" "P30041" "Peroxiredoxin-6 OS=Homo sapiens OX=9606 GN=PRDX6 PE=1 SV=3" "0.000" "False" "46.754" "42" "9" "58" "9" "224" "25.0" "6.38" "155.22" "9" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00578, Pf10417" "9588" "ENSG00000117592" "PRDX6" "A8JZY7; hsa:9588; P30041; P32077; Q5TAH4; Q5ZEZ8" "Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling" "Neutrophil degranulation; Detoxification of Reactive Oxygen Species" "5" "0" "0.969" "0.944" "0.953" "0.944" "0.973" "0.924" "1.026" "0.960" "0.605" "4116.2" "3990.5" "3886.1" "3924.1" "3884.7" "4003.8" "3804.0" "4223.1" "3952.3" "2488.3" "" "" "" "" "" "" "" "" "" "" "2463.3" "2073.7" "2152.0" "1842.3" "1800.6" "2049.6" "1768.8" "1895.9" "2144.3" "2488.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4642544614061212331" "False" "High" "IsMasterProtein" "P38159" "RNA-binding motif protein, X chromosome OS=Homo sapiens OX=9606 GN=RBMX PE=1 SV=3" "0.000" "False" "46.745" "29" "12" "32" "12" "391" "42.3" "10.05" "80.51" "12" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08081" "27316" "ENSG00000147274" "RBMX" "B4E3U4; D3DWH0; E9PG86; hsa:27316; P38159; Q5JQ67; Q8N8Y7; Q969R3" "mRNA processing" "RND2 GTPase cycle; mRNA Splicing - Major Pathway; RND3 GTPase cycle; RND1 GTPase cycle; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "8" "0" "0.976" "0.979" "0.925" "0.924" "0.985" "0.944" "1.064" "0.992" "0.511" "2265.5" "2210.1" "2216.8" "2095.5" "2092.2" "2231.5" "2138.5" "2410.9" "2247.3" "1158.7" "" "" "" "" "" "" "" "" "" "" "1355.7" "1148.5" "1227.6" "983.8" "969.8" "1142.4" "994.4" "1082.4" "1219.2" "1158.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6919500497101416540" "False" "High" "IsMasterProtein" "Q9UJU6" "Drebrin-like protein OS=Homo sapiens OX=9606 GN=DBNL PE=1 SV=1" "0.000" "False" "46.384" "30" "10" "14" "10" "430" "48.2" "5.05" "39.17" "10" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241, Pf14604" "28988" "ENSG00000136279" "DBNL" "A4D2I9; B4DDP6; B4DEM2; C9J7P1; hsa:28988; P84070; Q6IAI8; Q96F30; Q96K74; Q9HBN8; Q9NR72; Q9UJU6" "T-cell receptor signaling pathway" "Neutrophil degranulation; Neurexins and neuroligins; Caspase-mediated cleavage of cytoskeletal proteins" "4" "0" "1.122" "1.167" "1.089" "1.060" "1.097" "1.080" "0.912" "1.059" "1.993" "476.0" "533.9" "555.8" "518.5" "504.5" "522.4" "513.9" "434.0" "504.3" "948.8" "" "" "" "" "" "" "" "" "" "" "284.9" "277.4" "307.8" "243.4" "233.8" "267.4" "239.0" "194.8" "273.6" "948.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-108024960006830899" "False" "High" "IsMasterProtein" "Q99873" "Protein arginine N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=PRMT1 PE=1 SV=3" "0.000" "False" "46.251" "24" "8" "37" "8" "371" "42.4" "5.35" "90.11" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13649" "3276" "ENSG00000126457" "PRMT1" "A0A087X1W2; B4E3C3; G5E9B6; H7C2I1; hsa:3276; Q15529; Q2VP93; Q6LEU5; Q8WUW5; Q99872; Q99873; Q99874; Q9NZ04; Q9NZ05; Q9NZ06" "Energy metabolism; mRNA processing; Nitric oxide metabolism in cystic fibrosis; 16p11.2 distal deletion syndrome; Interferon type I signaling pathways" "Estrogen-dependent gene expression; Extra-nuclear estrogen signaling; RMTs methylate histone arginines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Maturation of nucleoprotein" "11" "0" "1.093" "0.951" "1.077" "1.000" "1.041" "0.985" "1.159" "0.966" "1.147" "1136.8" "1242.9" "1081.4" "1224.4" "1136.9" "1182.9" "1120.3" "1317.9" "1097.9" "1303.5" "" "" "" "" "" "" "" "" "" "" "680.3" "645.9" "598.9" "574.8" "527.0" "605.5" "520.9" "591.6" "595.6" "1303.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7179197342339518209" "False" "High" "IsMasterProtein" "P52907" "F-actin-capping protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=CAPZA1 PE=1 SV=3" "0.000" "False" "46.242" "29" "6" "25" "5" "286" "32.9" "5.69" "74.24" "6" "cell organization and biogenesis" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01267" "829" "ENSG00000116489" "CAPZA1" "hsa:829; P52907; Q53FQ6; Q6FHD5" "" "MHC class II antigen presentation; Sensory processing of sound by inner hair cells of the cochlea; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling" "8" "1" "1.104" "1.106" "1.095" "0.974" "0.993" "1.099" "1.083" "1.078" "0.930" "1401.4" "1546.4" "1550.3" "1535.0" "1364.5" "1392.2" "1540.1" "1518.2" "1510.0" "1303.0" "" "" "" "" "" "" "" "" "" "" "838.6" "803.6" "858.5" "720.7" "632.5" "712.7" "716.1" "681.6" "819.3" "1303.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3980314117452886183" "False" "High" "IsMasterProtein" "P62979" "Ubiquitin-ribosomal protein eS31 fusion protein OS=Homo sapiens OX=9606 GN=RPS27A PE=1 SV=2" "0.000" "False" "46.142" "50" "8" "132" "1" "156" "18.0" "9.64" "348.17" "8" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf01599" "6233" "ENSG00000143947" "RPS27A" "hsa:6233; P02248; P02249; P02250; P14798; P62979; P62988; Q29120; Q6LBL4; Q6LDU5; Q8WYN8; Q91887; Q91888; Q9BQ77; Q9BWD6; Q9BX98; Q9UEF2; Q9UEG1; Q9UEK8; Q9UPK7" "Cytoplasmic ribosomal proteins" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Aggrephagy; ISG15 antiviral mechanism; Downstream TCR signaling; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Oncogene Induced Senescence; ER-Phagosome pathway; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon alpha/beta signaling; Signaling by ALK fusions and activated point mutants; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus; Oxidative Stress Induced Senescence; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery; FCERI mediated NF-kB activation; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; Stimuli-sensing channels; Amyloid fiber formation; Fanconi Anemia Pathway; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; KEAP1-NFE2L2 pathway; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Peroxisomal protein import; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; ER Quality Control Compartment (ERQC); Deactivation of the beta-catenin transactivating complex; Circadian Clock; Regulation of signaling by CBL; Metalloprotease DUBs; Regulation of necroptotic cell death; Cyclin D associated events in G1; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Negative regulation of FLT3; Downregulation of ERBB2:ERBB3 signaling; Cargo recognition for clathrin-mediated endocytosis; Inactivation of CSF3 (G-CSF) signaling; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Regulation of TP53 Activity through Methylation; Regulation of BACH1 activity; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; Negative regulators of DDX58/IFIH1 signaling; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Prevention of phagosomal-lysosomal fusion; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Signaling by CSF1 (M-CSF) in myeloid cells; NOTCH1 Intracellular Domain Regulates Transcription; TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex; Glycogen synthesis; Formation of TC-NER Pre-Incision Complex; Modulation by Mtb of host immune system; IRAK2 mediated activation of TAK1 complex; SARS-CoV-1 activates/modulates innate immune responses; Alpha-protein kinase 1 signaling pathway; Ovarian tumor domain proteases; Spry regulation of FGF signaling; RAS processing; PINK1-PRKN Mediated Mitophagy; Josephin domain DUBs; Regulation of FZD by ubiquitination; Chaperone Mediated Autophagy; InlA-mediated entry of Listeria monocytogenes into host cells; Formation of Incision Complex in GG-NER; Iron uptake and transport; VLDLR internalisation and degradation; Myoclonic epilepsy of Lafora; Evasion by RSV of host interferon responses; DNA Damage Recognition in GG-NER; Negative regulation of MAPK pathway; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); NRIF signals cell death from the nucleus; Assembly Of The HIV Virion; Downregulation of ERBB4 signaling; Regulation of innate immune responses to cytosolic DNA; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Regulation of PTEN localization; Pexophagy; Maturation of protein E; Maturation of protein E; FLT3 signaling by CBL mutants; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "203" "7" "0.964" "0.965" "0.914" "0.994" "1.055" "0.992" "1.042" "0.945" "0.804" "8902.2" "8580.9" "8587.0" "8136.3" "8846.7" "9391.6" "8828.3" "9272.6" "8414.8" "7153.2" "" "" "" "" "" "" "" "" "" "" "5327.5" "4459.2" "4755.3" "3819.8" "4100.6" "4807.8" "4105.0" "4162.8" "4565.4" "7153.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6641856841102683489" "False" "High" "IsMasterProtein" "P62826" "GTP-binding nuclear protein Ran OS=Homo sapiens OX=9606 GN=RAN PE=1 SV=3" "0.000" "False" "46.137" "25" "6" "68" "6" "216" "24.4" "7.49" "190.79" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5901" "ENSG00000132341" "RAN" "A8K3Z8; hsa:5901; P17080; P28746; P28747; P62826; Q6IPB2; Q86V08; Q8NI90; Q9CSP3; Q9CWI7; Q9CZA2; Q9UDJ5; Q9UEU9" "Androgen receptor signaling pathway; miRNA biogenesis; 22q11.2 copy number variation syndrome" "Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Nuclear import of Rev protein; Transcriptional regulation by small RNAs; tRNA processing in the nucleus; Regulation of cholesterol biosynthesis by SREBP (SREBF); MicroRNA (miRNA) biogenesis; Postmitotic nuclear pore complex (NPC) reformation" "11" "0" "0.958" "0.948" "0.903" "1.005" "0.953" "1.041" "0.996" "1.061" "0.607" "5302.2" "5081.4" "5028.4" "4788.3" "5328.7" "5055.0" "5520.8" "5279.4" "5623.6" "3220.6" "" "" "" "" "" "" "" "" "" "" "3173.1" "2640.6" "2784.6" "2248.0" "2470.0" "2587.8" "2567.0" "2370.1" "3051.0" "3220.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8984223167418137130" "False" "High" "IsMasterProtein" "P62633" "CCHC-type zinc finger nucleic acid binding protein OS=Homo sapiens OX=9606 GN=CNBP PE=1 SV=1" "0.000" "False" "46.022" "55" "9" "23" "9" "177" "19.5" "7.71" "59.78" "9" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098" "7555" "ENSG00000169714" "CNBP" "A8K7V4; B2RAV9; B4DP17; D3DNB9; D3DNC0; D3DNC1; E9PDR7; hsa:7555; P20694; P62633; Q4JGY0; Q4JGY1; Q5QJR0; Q5U0E9; Q6PJI7; Q96NV3" "" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "1" "0" "1.036" "1.064" "1.038" "0.979" "1.075" "1.034" "1.122" "0.971" "0.637" "898.0" "930.3" "955.4" "931.9" "879.6" "965.3" "928.8" "1007.4" "871.6" "572.4" "" "" "" "" "" "" "" "" "" "" "537.4" "483.4" "529.1" "437.5" "407.7" "494.2" "431.9" "452.3" "472.9" "572.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4060364465058462245" "False" "High" "IsMasterProtein" "Q15435" "Protein phosphatase 1 regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PPP1R7 PE=1 SV=1" "0.000" "False" "46.019" "33" "11" "19" "11" "360" "41.5" "4.91" "48.10" "11" "other biological processes" "other cell component" "enzyme regulator activity" "Pf12799, Pf14580" "5510" "ENSG00000115685" "PPP1R7" "B4DFD4; B5MCY6; hsa:5510; Q15435; Q9UQE5; Q9UQE6; Q9Y6K4" "2q37 copy number variation syndrome" "" "1" "0" "1.164" "1.246" "1.204" "1.031" "1.158" "1.122" "1.006" "1.101" "2.192" "352.5" "410.3" "439.3" "424.3" "363.4" "408.1" "395.6" "354.5" "388.0" "772.8" "" "" "" "" "" "" "" "" "" "" "211.0" "213.2" "243.3" "199.2" "168.4" "208.9" "183.9" "159.2" "210.5" "772.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9088967002815659299" "False" "High" "IsMasterProtein" "P26641" "Elongation factor 1-gamma OS=Homo sapiens OX=9606 GN=EEF1G PE=1 SV=3" "0.000" "False" "45.941" "19" "9" "28" "9" "437" "50.1" "6.67" "78.42" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf00043, Pf00647, Pf02798" "1937" "ENSG00000254772" "EEF1G" "B4DTG2; hsa:1937; P26641; Q6PJ62; Q6PK31; Q96CU2; Q9P196" "Translation factors" "Signaling by ALK fusions and activated point mutants; Eukaryotic Translation Elongation" "3" "0" "1.016" "1.071" "1.091" "1.149" "1.032" "1.062" "0.611" "1.103" "6.259" "681.4" "692.4" "729.6" "743.3" "782.8" "703.5" "723.6" "416.1" "751.5" "4265.0" "" "" "" "" "" "" "" "" "" "" "407.8" "359.8" "404.0" "348.9" "362.9" "360.1" "336.4" "186.8" "407.7" "4265.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7705673583208632788" "False" "High" "IsMasterProtein" "P04183" "Thymidine kinase, cytosolic OS=Homo sapiens OX=9606 GN=TK1 PE=1 SV=2" "0.000" "False" "45.941" "39" "8" "45" "8" "234" "25.5" "8.51" "101.98" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00265" "7083" "ENSG00000167900" "TK1" "B2RC58; hsa:7083; P04183; Q969V0; Q9UMG9" "Fluoropyrimidine activity; Pyrimidine metabolism" "Pyrimidine salvage; G1/S-Specific Transcription" "4" "0" "0.952" "0.956" "1.008" "0.967" "1.009" "1.348" "1.594" "1.498" "0.670" "1385.8" "1318.9" "1324.9" "1397.0" "1340.7" "1398.9" "1868.5" "2209.2" "2075.3" "927.9" "" "" "" "" "" "" "" "" "" "" "829.3" "685.4" "733.7" "655.9" "621.4" "716.1" "868.8" "991.8" "1125.9" "927.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1629883586476679929" "False" "High" "IsMasterProtein" "Q9BT78" "COP9 signalosome complex subunit 4 OS=Homo sapiens OX=9606 GN=COPS4 PE=1 SV=1" "0.000" "False" "45.824" "34" "11" "21" "11" "406" "46.2" "5.83" "60.21" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01399, Pf18420" "51138" "ENSG00000138663" "COPS4" "B3KN88; B3KST5; hsa:51138; Q561W7; Q9BT78; Q9NW31; Q9Y677" "Ciliary landscape" "Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER; RHOBTB1 GTPase cycle" "6" "0" "1.035" "0.989" "1.056" "1.081" "1.030" "1.004" "1.057" "1.007" "0.785" "1258.8" "1303.4" "1245.3" "1329.5" "1360.5" "1296.7" "1263.4" "1330.8" "1267.6" "987.6" "" "" "" "" "" "" "" "" "" "" "753.3" "677.4" "689.6" "624.2" "630.6" "663.8" "587.4" "597.5" "687.7" "987.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2009427819375188157" "False" "High" "IsMasterProtein" "P62333" "26S proteasome regulatory subunit 10B OS=Homo sapiens OX=9606 GN=PSMC6 PE=1 SV=1" "0.000" "False" "45.717" "34" "11" "22" "11" "389" "44.1" "7.49" "51.02" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5706" "ENSG00000100519" "PSMC6" "B2R975; hsa:5706; P49719; P62333; Q6IBU3; Q92524" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "Separation of Sister Chromatids; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; SARS-CoV-1 targets host intracellular signalling and regulatory pathways" "65" "0" "1.080" "0.904" "1.063" "1.100" "1.140" "1.092" "1.108" "1.152" "0.736" "709.9" "766.7" "642.0" "754.6" "780.9" "809.0" "775.4" "786.8" "818.0" "522.4" "" "" "" "" "" "" "" "" "" "" "424.9" "398.4" "355.5" "354.3" "361.9" "414.1" "360.6" "353.2" "443.8" "522.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4038126070754837566" "False" "High" "IsMasterProtein" "Cont_Q3SYV4" "Adenylyl cyclase-associated protein 1 OS=Bos taurus OX=9913 GN=CAP1 PE=2 SV=3" "0.000" "True" "45.700" "21" "10" "39" "1" "472" "51.2" "7.52" "106.41" "10" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "cytoskeletal activity;other molecular function" "Pf01213, Pf08603" "109556455; 504519" "" "CAP1" "A0A6P5BIK1; biu:109556455; bta:504519; Q3SYV4" "" "" "0" "0" "1.118" "0.981" "1.787" "1.387" "1.428" "1.128" "0.982" "1.178" "1.116" "33.3" "37.2" "32.6" "59.4" "46.1" "47.5" "37.5" "32.6" "39.2" "37.1" "" "" "" "" "" "" "" "" "" "" "19.9" "19.3" "18.1" "27.9" "21.4" "24.3" "17.4" "14.7" "21.3" "37.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5833035186099414895" "False" "High" "IsMasterProtein" "Q96KR1" "Zinc finger RNA-binding protein OS=Homo sapiens OX=9606 GN=ZFR PE=1 SV=2" "0.000" "False" "45.582" "14" "14" "19" "14" "1074" "116.9" "9.04" "47.38" "14" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07528, Pf12874, Pf20965" "51663" "ENSG00000056097" "ZFR" "B2RNR5; hsa:51663; Q05C08; Q3B7X5; Q6P5A3; Q86UA0; Q96KR1; Q9H6V4; Q9NTI1; Q9Y687" "Exercise-induced circadian regulation" "" "1" "0" "1.075" "1.042" "1.016" "1.068" "1.097" "1.044" "1.110" "1.076" "0.826" "868.2" "933.6" "905.0" "882.4" "927.1" "952.4" "906.5" "964.0" "934.2" "717.2" "" "" "" "" "" "" "" "" "" "" "519.6" "485.1" "501.1" "414.2" "429.7" "487.6" "421.5" "432.8" "506.9" "717.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4912222715256496910" "False" "High" "IsMasterProtein" "O43390" "Heterogeneous nuclear ribonucleoprotein R OS=Homo sapiens OX=9606 GN=HNRNPR PE=1 SV=1" "0.000" "False" "45.516" "19" "11" "30" "4" "633" "70.9" "8.13" "76.87" "11" "RNA metabolism OR transcription;other metabolic processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf18360" "10236" "ENSG00000125944; ENSG00000282958" "HNRNPR" "hsa:10236; O43390; Q2L7G6; Q5TEH1; Q9BV64; S4R3J4" "mRNA processing" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "3" "0" "1.087" "1.320" "1.095" "1.264" "1.274" "1.270" "1.000" "1.135" "5.040" "144.5" "157.1" "190.9" "158.2" "182.7" "184.2" "183.5" "144.6" "164.1" "728.5" "" "" "" "" "" "" "" "" "" "" "86.5" "81.7" "105.7" "74.3" "84.7" "94.3" "85.3" "64.9" "89.0" "728.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8235165147539186554" "False" "High" "IsMasterProtein" "Q16666" "Gamma-interferon-inducible protein 16 OS=Homo sapiens OX=9606 GN=IFI16 PE=1 SV=3" "0.000" "False" "45.480" "18" "12" "22" "12" "785" "88.2" "9.28" "57.61" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02758, Pf02760" "3428" "ENSG00000163565" "IFI16" "A0A346JEQ3; B4DJT8; H3BLV7; hsa:3428; Q16666; Q59GX0; Q5T3W7; Q5T3W8; Q5T3X0; Q5T3X1; Q5T3X2; Q8N9E5; Q8NEQ7; Q96AJ5; Q9UH78" "" "IRF3-mediated induction of type I IFN" "2" "0" "1.011" "1.194" "1.020" "1.051" "1.028" "1.080" "0.403" "0.923" "9.583" "297.8" "301.3" "355.7" "303.9" "313.1" "306.2" "321.7" "120.1" "275.0" "2854.1" "" "" "" "" "" "" "" "" "" "" "178.2" "156.6" "197.0" "142.7" "145.1" "156.8" "149.6" "53.9" "149.2" "2854.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3366486650245995426" "False" "High" "IsMasterProtein" "P10515" "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLAT PE=1 SV=3" "0.000" "False" "45.345" "21" "12" "47" "12" "647" "69.0" "7.84" "124.06" "12" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00198, Pf00364, Pf02817" "1737" "ENSG00000150768" "DLAT" "hsa:1737; P10515; Q16783; Q53EP3" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "8" "0" "1.036" "1.006" "1.054" "1.027" "1.030" "0.977" "1.055" "0.974" "0.752" "3195.8" "3310.3" "3213.7" "3368.8" "3282.4" "3291.2" "3123.5" "3371.0" "3111.6" "2403.5" "" "" "" "" "" "" "" "" "" "" "1912.5" "1720.2" "1779.7" "1581.6" "1521.4" "1684.8" "1452.4" "1513.4" "1688.2" "2403.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2843591473366045892" "False" "High" "IsMasterProtein" "P62136" "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CA PE=1 SV=1" "0.000" "False" "45.215" "37" "10" "26" "3" "330" "37.5" "6.33" "61.66" "10" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5499" "ENSG00000172531" "PPP1CA" "A6NNR3; B2R908; hsa:5499; P08129; P20653; P22802; P62136; Q07161" "Sphingolipid pathway; Nicotine effect on dopaminergic neurons; Common pathways underlying drug addiction; Focal adhesion; VEGFA-VEGFR2 signaling; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Netrin-UNC5B signaling pathway; Neuroinflammation and glutamatergic signaling; HDAC6 interactions in the central nervous system" "Triglyceride catabolism; Circadian Clock; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins; DARPP-32 events" "15" "5" "1.020" "1.059" "0.977" "1.006" "0.963" "1.032" "1.000" "0.967" "0.994" "975.8" "995.8" "1033.2" "953.7" "981.3" "939.9" "1006.8" "976.0" "944.0" "970.0" "" "" "" "" "" "" "" "" "" "" "584.0" "517.5" "572.2" "447.7" "454.8" "481.1" "468.2" "438.2" "512.2" "970.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4754969911618934256" "False" "High" "IsMasterProtein" "Q5H9R7" "Serine/threonine-protein phosphatase 6 regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PPP6R3 PE=1 SV=2" "0.000" "False" "45.139" "15" "11" "15" "11" "873" "97.6" "4.60" "45.08" "11" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf04499" "55291" "ENSG00000110075" "PPP6R3" "hsa:55291; Q3B7I1; Q3I4Y0; Q3KR35; Q5H9R7; Q68CR3; Q7L4R8; Q8N3B2; Q96MB2; Q9H2K5; Q9H2K6; Q9HCL4; Q9NUY3" "" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "2" "0" "1.064" "0.961" "0.991" "1.024" "0.997" "1.023" "1.087" "1.032" "0.667" "1311.6" "1396.0" "1260.4" "1299.2" "1342.7" "1308.2" "1342.1" "1426.0" "1353.0" "874.3" "" "" "" "" "" "" "" "" "" "" "784.9" "725.4" "698.0" "609.9" "622.4" "669.7" "624.0" "640.2" "734.1" "874.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7637669709604963095" "False" "High" "IsMasterProtein" "Q12888" "TP53-binding protein 1 OS=Homo sapiens OX=9606 GN=TP53BP1 PE=1 SV=2" "0.000" "False" "45.136" "11" "16" "16" "16" "1972" "213.4" "4.70" "27.88" "16" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09038, Pf18428" "7158" "ENSG00000067369" "TP53BP1" "F8VY86; hsa:7158; Q12888; Q2M1Z7; Q4LE46; Q5FWZ3; Q7Z3U4" "ATM signaling pathway; ATM signaling in development and disease" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription factors; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "7" "0" "1.044" "1.070" "1.145" "1.096" "1.071" "1.191" "1.143" "1.055" "1.857" "269.8" "281.7" "288.6" "309.0" "295.8" "289.0" "321.3" "308.3" "284.5" "501.1" "" "" "" "" "" "" "" "" "" "" "161.5" "146.4" "159.8" "145.1" "137.1" "147.9" "149.4" "138.4" "154.4" "501.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3936589147855356359" "False" "High" "IsMasterProtein" "P54886" "Delta-1-pyrroline-5-carboxylate synthase OS=Homo sapiens OX=9606 GN=ALDH18A1 PE=1 SV=2" "0.000" "False" "45.095" "16" "13" "24" "13" "795" "87.2" "7.12" "55.96" "13" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf00171, Pf00696" "5832" "ENSG00000059573" "ALDH18A1" "B2R5Q4; B7Z350; B7Z5X8; B7ZLP1; D3DR44; hsa:5832; O95952; P54886; Q3KQU2; Q5T566; Q5T567; Q9UM72" "Amino acid metabolism" "Mitochondrial protein degradation" "2" "0" "0.975" "0.910" "1.054" "1.057" "1.035" "1.078" "0.859" "0.962" "2.720" "913.1" "890.5" "831.2" "962.5" "964.9" "945.0" "984.7" "784.6" "878.7" "2483.7" "" "" "" "" "" "" "" "" "" "" "546.5" "462.7" "460.3" "451.9" "447.2" "483.8" "457.9" "352.2" "476.7" "2483.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-990721738298047914" "False" "High" "IsMasterProtein" "O00299" "Chloride intracellular channel protein 1 OS=Homo sapiens OX=9606 GN=CLIC1 PE=1 SV=4" "0.000" "False" "45.037" "50" "9" "56" "9" "241" "26.9" "5.17" "135.14" "9" "transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "transporter activity" "Pf13409, Pf13410" "1192" "ENSG00000206394; ENSG00000213719; ENSG00000223639; ENSG00000226248; ENSG00000226417; ENSG00000226651; ENSG00000230685" "CLIC1" "hsa:1192; O00299; Q15089; Q502X1" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.020" "1.091" "1.052" "1.010" "1.077" "0.927" "0.998" "1.036" "1.197" "3196.3" "3261.4" "3486.9" "3362.2" "3229.7" "3442.4" "2963.9" "3190.3" "3312.9" "3824.5" "" "" "" "" "" "" "" "" "" "" "1912.8" "1694.8" "1931.0" "1578.5" "1497.0" "1762.2" "1378.1" "1432.2" "1797.4" "3824.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3813032805198607075" "False" "High" "IsMasterProtein" "Q9NVA2" "Septin-11 OS=Homo sapiens OX=9606 GN=SEPTIN11 PE=1 SV=3" "0.000" "False" "44.962" "19" "7" "26" "3" "429" "49.4" "6.81" "59.79" "7" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00735" "55752" "ENSG00000138758" "SEPTIN11" "B7Z7Z6; E9KL32; hsa:55752; Q4W5G1; Q7L4N1; Q96SP1; Q9NVA2; Q9UFY9" "22q11.2 copy number variation syndrome" "" "1" "0" "1.039" "1.032" "1.092" "0.991" "0.944" "1.131" "1.132" "1.049" "0.651" "283.5" "294.4" "292.5" "309.5" "280.9" "267.7" "320.6" "321.0" "297.3" "184.6" "" "" "" "" "" "" "" "" "" "" "169.7" "153.0" "162.0" "145.3" "130.2" "137.1" "149.1" "144.1" "161.3" "184.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6330757226080927514" "False" "High" "IsMasterProtein" "P67775" "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP2CA PE=1 SV=1" "0.000" "False" "44.691" "39" "10" "42" "2" "309" "35.6" "5.54" "104.06" "10" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00149" "5515" "ENSG00000113575" "PPP2CA" "hsa:5515; P05323; P13197; P67775" "Sphingolipid pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Dopamine metabolism; Mesodermal commitment pathway; Mesodermal commitment pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Cancer immunotherapy by CTLA4 blockade; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; DARPP-32 events; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); PKR-mediated signaling; Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "53" "5" "0.948" "1.004" "0.926" "1.007" "0.935" "1.041" "1.027" "1.086" "0.737" "1625.5" "1540.9" "1632.3" "1505.3" "1636.8" "1519.1" "1692.0" "1668.8" "1766.1" "1197.5" "" "" "" "" "" "" "" "" "" "" "972.8" "800.8" "903.9" "706.7" "758.7" "777.6" "786.8" "749.2" "958.2" "1197.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4773020118127395212" "False" "High" "IsMasterProtein" "P30740" "Leukocyte elastase inhibitor OS=Homo sapiens OX=9606 GN=SERPINB1 PE=1 SV=1" "0.000" "False" "44.561" "30" "11" "15" "11" "379" "42.7" "6.28" "42.86" "11" "cell cycle OR cell proliferation;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf00079" "1992" "ENSG00000021355" "SERPINB1" "A8K5L2; B4DNT0; hsa:1992; P30740; Q53FB9; Q5W0E1; Q9UDF8" "Vitamin D receptor pathway" "Neutrophil degranulation" "2" "0" "1.070" "0.990" "1.082" "1.042" "1.067" "1.043" "0.992" "1.017" "1.017" "792.2" "847.7" "784.3" "857.0" "825.2" "845.4" "826.0" "786.2" "805.8" "805.3" "" "" "" "" "" "" "" "" "" "" "474.1" "440.5" "434.3" "402.4" "382.5" "432.8" "384.1" "353.0" "437.2" "805.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1866201622056559647" "False" "High" "IsMasterProtein" "Q13263" "Transcription intermediary factor 1-beta OS=Homo sapiens OX=9606 GN=TRIM28 PE=1 SV=5" "0.000" "False" "44.551" "12" "9" "20" "9" "835" "88.5" "5.77" "52.31" "9" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00628, Pf00643, Pf14634" "10155" "ENSG00000130726" "TRIM28" "hsa:10155; O00677; Q13263; Q7Z632; Q93040; Q96IM1" "Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; ATM signaling in development and disease" "HCMV Early Events; Generic Transcription Pathway; SUMOylation of transcription cofactors" "6" "0" "1.029" "1.254" "1.220" "1.135" "1.131" "1.211" "0.634" "1.152" "6.336" "328.1" "337.6" "411.3" "400.2" "372.4" "371.2" "397.2" "208.0" "378.1" "2078.8" "" "" "" "" "" "" "" "" "" "" "196.3" "175.5" "227.8" "187.9" "172.6" "190.0" "184.7" "93.4" "205.1" "2078.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7382790352375516909" "False" "High" "IsMasterProtein" "Q15393" "Splicing factor 3B subunit 3 OS=Homo sapiens OX=9606 GN=SF3B3 PE=1 SV=4" "0.000" "False" "44.509" "11" "14" "29" "14" "1217" "135.5" "5.26" "66.48" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "23450" "ENSG00000189091" "SF3B3" "hsa:23450; Q15393; Q6NTI8; Q96GC0; Q9BPY2; Q9UFX7; Q9UJ29" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "0.984" "1.093" "1.045" "1.079" "1.013" "1.054" "0.945" "1.012" "1.962" "806.1" "793.3" "880.7" "842.6" "869.5" "816.6" "849.8" "761.8" "815.4" "1581.7" "" "" "" "" "" "" "" "" "" "" "482.4" "412.2" "487.7" "395.6" "403.0" "418.1" "395.1" "342.0" "442.4" "1581.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5413684009215812555" "False" "High" "IsMasterProtein" "O15143" "Actin-related protein 2/3 complex subunit 1B OS=Homo sapiens OX=9606 GN=ARPC1B PE=1 SV=3" "0.000" "False" "44.444" "28" "9" "48" "9" "372" "40.9" "8.35" "134.29" "9" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400" "10095" "ENSG00000130429" "ARPC1B" "hsa:10095; O15143; Q9BU00" "Pathogenic Escherichia coli infection; Microglia pathogen phagocytosis pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling" "6" "0" "0.958" "0.955" "0.965" "0.900" "0.982" "0.981" "0.959" "1.058" "0.679" "1920.8" "1839.3" "1833.7" "1853.8" "1728.2" "1886.1" "1884.4" "1842.4" "2031.8" "1305.1" "" "" "" "" "" "" "" "" "" "" "1149.5" "955.8" "1015.5" "870.3" "801.1" "965.5" "876.2" "827.1" "1102.4" "1305.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-453379581051164535" "False" "High" "IsMasterProtein" "P30086" "Phosphatidylethanolamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PEBP1 PE=1 SV=3" "0.000" "False" "44.409" "40" "7" "77" "7" "187" "21.0" "7.53" "217.22" "7" "other biological processes" "cytosol" "enzyme regulator activity;other molecular function" "Pf01161" "5037" "ENSG00000089220" "PEBP1" "B2R4S1; hsa:5037; P30086" "Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "9" "0" "0.969" "1.000" "0.956" "0.979" "0.948" "0.986" "1.006" "0.921" "0.460" "5701.4" "5526.3" "5701.7" "5451.0" "5583.7" "5405.1" "5623.9" "5736.5" "5250.0" "2621.3" "" "" "" "" "" "" "" "" "" "" "3412.0" "2871.8" "3157.5" "2559.1" "2588.2" "2767.0" "2615.0" "2575.3" "2848.3" "2621.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1479790111935506116" "False" "High" "IsMasterProtein" "Q9P258" "Protein RCC2 OS=Homo sapiens OX=9606 GN=RCC2 PE=1 SV=2" "0.000" "False" "44.363" "23" "11" "25" "11" "522" "56.0" "8.78" "74.33" "11" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00415" "55920" "ENSG00000179051; ENSG00000281540" "RCC2" "hsa:55920; Q8IVL9; Q9BSN6; Q9NPV8; Q9P258" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.026" "1.003" "1.121" "1.070" "1.037" "0.979" "0.890" "0.936" "2.026" "1382.8" "1418.6" "1386.6" "1549.9" "1479.5" "1433.9" "1353.7" "1231.0" "1294.3" "2801.8" "" "" "" "" "" "" "" "" "" "" "827.5" "737.2" "767.9" "727.6" "685.8" "734.0" "629.4" "552.7" "702.2" "2801.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7448021442665095265" "False" "High" "IsMasterProtein" "O95347" "Structural maintenance of chromosomes protein 2 OS=Homo sapiens OX=9606 GN=SMC2 PE=1 SV=2" "0.000" "False" "44.332" "10" "13" "14" "13" "1197" "135.6" "8.43" "40.49" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "10592" "ENSG00000136824" "SMC2" "hsa:10592; O95347; Q6IEE0; Q9P1P2" "Retinoblastoma gene in cancer" "Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes" "3" "0" "1.098" "1.029" "1.130" "1.158" "1.155" "1.025" "0.466" "1.054" "9.092" "322.9" "354.6" "332.3" "365.0" "373.9" "373.1" "331.1" "150.5" "340.4" "2936.3" "" "" "" "" "" "" "" "" "" "" "193.3" "184.3" "184.0" "171.4" "173.3" "191.0" "153.9" "67.5" "184.7" "2936.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-154520297388586765" "False" "High" "IsMasterProtein" "Q9HCC0" "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Homo sapiens OX=9606 GN=MCCC2 PE=1 SV=1" "0.000" "False" "44.329" "20" "10" "20" "10" "563" "61.3" "7.68" "58.67" "10" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01039" "64087" "ENSG00000131844" "MCCC2" "A6NIY9; hsa:64087; Q96C27; Q9HCC0; Q9Y4L7" "" "Biotin transport and metabolism; Branched-chain amino acid catabolism; Defective HLCS causes multiple carboxylase deficiency" "3" "0" "1.010" "0.980" "1.011" "0.997" "1.051" "1.036" "1.064" "1.062" "0.647" "715.8" "722.9" "701.7" "723.4" "714.0" "752.4" "741.7" "761.7" "760.0" "463.5" "" "" "" "" "" "" "" "" "" "" "428.4" "375.7" "388.6" "339.6" "331.0" "385.2" "344.9" "342.0" "412.3" "463.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4018200245095699536" "False" "High" "IsMasterProtein" "P55327" "Tumor protein D52 OS=Homo sapiens OX=9606 GN=TPD52 PE=1 SV=2" "0.000" "False" "44.278" "21" "4" "32" "4" "224" "24.3" "4.83" "101.46" "4" "transport;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf04201" "7163" "ENSG00000076554" "TPD52" "B7Z414; C9J502; D0UFD1; D0UFD2; D0UFD3; D0UFD4; D0UFD5; E5RKB4; hsa:7163; P55327; Q13056; Q53EK8; Q6FGP3; Q6FGS3; Q86YZ2; Q9UCX8" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "1.045" "0.951" "0.954" "1.096" "1.076" "1.134" "1.115" "1.082" "0.632" "1700.3" "1776.3" "1616.7" "1622.8" "1863.1" "1829.6" "1927.4" "1895.0" "1840.1" "1075.1" "" "" "" "" "" "" "" "" "" "" "1017.5" "923.1" "895.3" "761.9" "863.6" "936.6" "896.2" "850.7" "998.3" "1075.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9008482199911470815" "False" "High" "IsMasterProtein" "O43516" "WAS/WASL-interacting protein family member 1 OS=Homo sapiens OX=9606 GN=WIPF1 PE=1 SV=3" "0.000" "False" "44.041" "18" "8" "28" "8" "503" "51.2" "11.47" "84.03" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "7456" "ENSG00000115935" "WIPF1" "B8ZZM1; D3DPE4; hsa:7456; O43516; Q15220; Q53TA9; Q6MZU9; Q9BU37; Q9UNP1" "" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs" "5" "0" "1.058" "1.025" "1.081" "1.134" "1.119" "1.090" "1.143" "1.041" "1.077" "1441.1" "1525.3" "1477.7" "1558.0" "1634.0" "1612.5" "1570.3" "1647.7" "1500.2" "1552.4" "" "" "" "" "" "" "" "" "" "" "862.4" "792.7" "818.3" "731.5" "757.4" "825.5" "730.1" "739.7" "813.9" "1552.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4008936127769007747" "False" "High" "IsMasterProtein" "O43314" "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 OS=Homo sapiens OX=9606 GN=PPIP5K2 PE=1 SV=3" "0.000" "False" "43.950" "12" "13" "22" "13" "1243" "140.3" "8.22" "52.09" "13" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf00328, Pf18086" "23262" "ENSG00000145725" "PPIP5K2" "A1NI53; A6NGS8; hsa:23262; O43314; Q8TB50" "" "Synthesis of pyrophosphates in the cytosol" "1" "0" "1.033" "1.032" "1.022" "1.003" "1.089" "1.061" "1.080" "1.043" "0.819" "1033.9" "1067.8" "1067.4" "1056.7" "1036.5" "1125.7" "1097.0" "1116.7" "1078.4" "846.5" "" "" "" "" "" "" "" "" "" "" "618.7" "554.9" "591.1" "496.1" "480.4" "576.3" "510.1" "501.3" "585.1" "846.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7305935062523076867" "False" "High" "IsMasterProtein" "Q9Y3Z3" "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Homo sapiens OX=9606 GN=SAMHD1 PE=1 SV=2" "0.000" "False" "43.890" "20" "13" "25" "13" "626" "72.2" "7.14" "55.62" "13" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01966, Pf07647" "25939" "ENSG00000101347" "SAMHD1" "B4E2A5; E1P5V2; hsa:25939; Q5JXG8; Q8N491; Q9H004; Q9H005; Q9H3U9; Q9Y3Z3" "" "Interferon alpha/beta signaling; Nucleotide catabolism" "2" "0" "0.933" "0.880" "1.014" "1.070" "0.980" "0.930" "0.883" "0.853" "1.072" "1041.0" "971.8" "915.6" "1055.3" "1114.0" "1020.2" "968.3" "919.6" "887.6" "1115.8" "" "" "" "" "" "" "" "" "" "" "623.0" "505.0" "507.1" "495.5" "516.4" "522.3" "450.2" "412.8" "481.6" "1115.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625236690753071245" "False" "High" "IsMasterProtein" "P22061" "Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens OX=9606 GN=PCMT1 PE=1 SV=4" "0.000" "False" "43.652" "44" "9" "31" "9" "227" "24.6" "7.21" "66.82" "9" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01135" "5110" "ENSG00000120265" "PCMT1" "A8K109; hsa:5110; J3KP72; P22061; Q14661; Q16556; Q5VYC1; Q5VYC2; Q93061; Q96II9; Q99625; Q9BQV7; Q9BQV8; Q9NP03" "Primary ovarian insufficiency" "Protein repair" "2" "0" "0.981" "0.979" "1.034" "1.035" "1.009" "1.059" "1.027" "1.098" "0.666" "1269.7" "1246.1" "1243.7" "1312.6" "1313.7" "1281.5" "1344.9" "1304.1" "1394.2" "845.8" "" "" "" "" "" "" "" "" "" "" "759.9" "647.5" "688.7" "616.2" "608.9" "656.0" "625.4" "585.5" "756.4" "845.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4629403927496459035" "False" "High" "IsMasterProtein" "P62987" "Ubiquitin-ribosomal protein eL40 fusion protein OS=Homo sapiens OX=9606 GN=UBA52 PE=1 SV=2" "0.000" "False" "43.587" "54" "8" "134" "1" "128" "14.7" "9.83" "346.38" "8" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf01020" "7311" "ENSG00000221983" "UBA52" "hsa:7311; P02248; P02249; P02250; P14793; P62987; P62988; Q29120; Q6LBL4; Q6LDU5; Q8WYN8; Q91887; Q91888; Q9BWD6; Q9BX98; Q9UEF2; Q9UEG1; Q9UEK8; Q9UPK7" "DNA replication; Cytoplasmic ribosomal proteins" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; KEAP1-NFE2L2 pathway; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Major pathway of rRNA processing in the nucleolus and cytosol; Membrane binding and targetting of GAG proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Circadian Clock; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; Peroxisomal protein import; Regulation of PLK1 Activity at G2/M Transition; Regulation of TP53 Degradation; APC/C:Cdc20 mediated degradation of Cyclin B; Ovarian tumor domain proteases; Regulation of signaling by CBL; Signaling by CSF1 (M-CSF) in myeloid cells; Cyclin D associated events in G1; Inactivation of CSF3 (G-CSF) signaling; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; MAP3K8 (TPL2)-dependent MAPK1/3 activation; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; SARS-CoV-1 activates/modulates innate immune responses; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Stimuli-sensing channels; Amyloid fiber formation; Fanconi Anemia Pathway; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Aggrephagy; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 HD Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; ER Quality Control Compartment (ERQC); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of TP53 Activity through Phosphorylation; Signaling by ALK fusions and activated point mutants; Metalloprotease DUBs; Regulation of necroptotic cell death; Oncogene Induced Senescence; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Negative regulation of FLT3; Downregulation of ERBB2:ERBB3 signaling; Cargo recognition for clathrin-mediated endocytosis; Interferon alpha/beta signaling; Regulation of TP53 Activity through Methylation; Processing of DNA double-strand break ends; Regulation of BACH1 activity; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Prevention of phagosomal-lysosomal fusion; Downregulation of TGF-beta receptor signaling; HDR through Homologous Recombination (HRR); TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex; Glycogen synthesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Modulation by Mtb of host immune system; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; Spry regulation of FGF signaling; RAS processing; PINK1-PRKN Mediated Mitophagy; Josephin domain DUBs; Regulation of FZD by ubiquitination; Chaperone Mediated Autophagy; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; InlA-mediated entry of Listeria monocytogenes into host cells; Formation of Incision Complex in GG-NER; Iron uptake and transport; Recognition of DNA damage by PCNA-containing replication complex; VLDLR internalisation and degradation; Myoclonic epilepsy of Lafora; Evasion by RSV of host interferon responses; DNA Damage Recognition in GG-NER; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Negative regulation of MAPK pathway; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); NRIF signals cell death from the nucleus; Assembly Of The HIV Virion; Dual Incision in GG-NER; Translesion Synthesis by POLH; Downregulation of ERBB4 signaling; Regulation of innate immune responses to cytosolic DNA; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Gap-filling DNA repair synthesis and ligation in GG-NER; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Regulation of PTEN localization; Pexophagy; Maturation of protein E; Maturation of protein E; FLT3 signaling by CBL mutants; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "199" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7688952667704275831" "False" "High" "IsMasterProtein" "O14818" "Proteasome subunit alpha type-7 OS=Homo sapiens OX=9606 GN=PSMA7 PE=1 SV=1" "0.000" "False" "43.576" "38" "9" "45" "6" "248" "27.9" "8.46" "112.74" "9" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf10584" "5688" "ENSG00000101182" "PSMA7" "B2R515; hsa:5688; O14818; Q5JXJ2; Q9BR53; Q9H4K5; Q9UEU8" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "2" "1.011" "1.044" "1.102" "1.080" "1.024" "1.003" "1.159" "1.061" "0.755" "1398.6" "1413.5" "1459.5" "1540.6" "1510.6" "1432.2" "1402.3" "1621.6" "1483.7" "1055.3" "" "" "" "" "" "" "" "" "" "" "837.0" "734.6" "808.2" "723.3" "700.2" "733.2" "652.1" "728.0" "805.0" "1055.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "306109377846906281" "False" "High" "IsMasterProtein" "P49247" "Ribose-5-phosphate isomerase OS=Homo sapiens OX=9606 GN=RPIA PE=1 SV=3" "0.000" "False" "43.498" "37" "10" "28" "10" "311" "33.2" "8.54" "65.06" "10" "other metabolic processes" "cytosol" "other molecular function" "Pf06026" "22934" "ENSG00000153574" "RPIA" "hsa:22934; P49247; Q541P9; Q96BJ6" "Pentose phosphate metabolism; Metabolic reprogramming in colon cancer; Pentose phosphate pathway in senescent cells" "Pentose phosphate pathway; RPIA deficiency: failed conversion of R5P to RU5P; RPIA deficiency: failed conversion of RU5P to R5P" "6" "0" "0.980" "0.902" "0.911" "0.985" "0.860" "1.105" "0.921" "1.059" "0.573" "1618.3" "1585.5" "1459.2" "1474.4" "1594.7" "1392.5" "1788.0" "1489.7" "1714.4" "928.0" "" "" "" "" "" "" "" "" "" "" "968.5" "823.9" "808.1" "692.2" "739.2" "712.9" "831.4" "668.8" "930.1" "928.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3731678403857668842" "False" "High" "IsMasterProtein" "P10768" "S-formylglutathione hydrolase OS=Homo sapiens OX=9606 GN=ESD PE=1 SV=2" "0.000" "False" "43.490" "33" "8" "36" "8" "282" "31.4" "7.02" "110.59" "8" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00756" "2098" "ENSG00000139684" "ESD" "hsa:2098; P10768; Q5TBU8; Q5TBV0; Q5TBV2; Q9BVJ2" "Phase I biotransformations, non-P450" "Glutathione conjugation" "2" "0" "1.001" "1.018" "1.016" "0.937" "1.015" "0.923" "1.060" "0.986" "0.700" "3314.9" "3319.3" "3375.6" "3367.5" "3105.0" "3363.6" "3059.6" "3514.7" "3267.3" "2318.9" "" "" "" "" "" "" "" "" "" "" "1983.8" "1724.9" "1869.3" "1580.9" "1439.2" "1721.9" "1422.7" "1577.9" "1772.6" "2318.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2531564844693564972" "False" "High" "IsMasterProtein" "O75475" "PC4 and SFRS1-interacting protein OS=Homo sapiens OX=9606 GN=PSIP1 PE=1 SV=1" "0.000" "False" "43.461" "25" "13" "26" "12" "530" "60.1" "9.13" "72.48" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00855, Pf11467" "11168" "ENSG00000164985" "PSIP1" "D3DRI9; hsa:11168; O00256; O75475; O95368; Q6P391; Q86YB9; Q9NZI3; Q9UER6" "MECP2 and associated Rett syndrome" "Vpr-mediated nuclear import of PICs; Formation of WDR5-containing histone-modifying complexes; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection" "8" "0" "1.083" "1.067" "1.054" "1.069" "1.095" "0.986" "0.991" "1.028" "1.578" "1131.6" "1225.9" "1207.0" "1192.3" "1210.1" "1238.8" "1116.2" "1120.9" "1163.6" "1785.6" "" "" "" "" "" "" "" "" "" "" "677.2" "637.0" "668.4" "559.7" "560.9" "634.2" "519.0" "503.2" "631.3" "1785.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8985233522455606046" "False" "High" "IsMasterProtein" "P61758" "Prefoldin subunit 3 OS=Homo sapiens OX=9606 GN=VBP1 PE=1 SV=4" "0.000" "False" "43.310" "37" "9" "27" "9" "197" "22.6" "7.11" "76.63" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02996" "7411" "ENSG00000155959" "VBP1" "B2R8L5; B4DWR3; F5H2A7; hsa:7411; O55228; P61758; Q15765; Q5JT81; Q86X96" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "1.040" "0.971" "0.966" "1.038" "1.009" "1.064" "1.051" "1.006" "0.588" "2259.7" "2350.1" "2194.0" "2183.2" "2346.0" "2280.3" "2405.1" "2374.8" "2274.2" "1328.8" "" "" "" "" "" "" "" "" "" "" "1352.3" "1221.3" "1215.0" "1025.0" "1087.4" "1167.3" "1118.3" "1066.1" "1233.9" "1328.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5172052490398288729" "False" "High" "IsMasterProtein" "Q9H9S4" "Calcium-binding protein 39-like OS=Homo sapiens OX=9606 GN=CAB39L PE=1 SV=3" "0.000" "False" "43.310" "32" "12" "28" "10" "337" "39.1" "8.40" "76.82" "12" "signal transduction" "cytosol;other cell component" "enzyme regulator activity" "Pf08569" "81617" "ENSG00000102547" "CAB39L" "hsa:81617; Q5TAW6; Q6WG71; Q96FG1; Q9BZ33; Q9H9S4" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Energy dependent regulation of mTOR by LKB1-AMPK" "2" "0" "1.150" "1.228" "1.183" "1.178" "1.199" "1.086" "1.118" "1.173" "1.297" "808.7" "929.9" "992.7" "956.7" "952.6" "969.2" "878.3" "903.8" "948.3" "1049.0" "" "" "" "" "" "" "" "" "" "" "483.9" "483.2" "549.7" "449.1" "441.6" "496.2" "408.4" "405.8" "514.5" "1049.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4945442823809026460" "False" "High" "IsMasterProtein" "O95861" "3'(2'),5'-bisphosphate nucleotidase 1 OS=Homo sapiens OX=9606 GN=BPNT1 PE=1 SV=1" "0.000" "False" "43.187" "31" "9" "40" "9" "308" "33.4" "5.69" "119.66" "9" "other metabolic processes;developmental processes" "cytosol" "other molecular function" "Pf00459" "10380" "ENSG00000162813" "BPNT1" "A8K7C8; B4DPS5; B4DUS9; D3DTA9; hsa:10380; O95861; Q8WVL5; Q9UGJ3" "" "Cytosolic sulfonation of small molecules" "1" "0" "0.998" "0.968" "1.046" "1.003" "1.049" "0.970" "1.058" "1.016" "0.630" "1611.5" "1607.8" "1559.9" "1686.1" "1615.9" "1689.7" "1563.4" "1704.5" "1638.0" "1016.0" "" "" "" "" "" "" "" "" "" "" "964.4" "835.5" "863.9" "791.6" "749.0" "865.0" "726.9" "765.2" "888.7" "1016.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3977231737757699064" "False" "High" "IsMasterProtein" "Q6JBY9" "CapZ-interacting protein OS=Homo sapiens OX=9606 GN=RCSD1 PE=1 SV=1" "0.000" "False" "43.178" "20" "7" "17" "7" "416" "44.5" "5.40" "52.07" "7" "stress response;transport;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf05177, Pf15255" "92241" "ENSG00000198771" "RCSD1" "B1AK48; hsa:92241; Q4G0E7; Q6IN93; Q6JBY9; Q8IZM2; Q96DX0; Q9NST4" "" "" "0" "0" "0.951" "0.928" "0.880" "0.908" "0.921" "0.983" "0.950" "0.901" "0.352" "1489.3" "1417.0" "1381.6" "1310.8" "1352.0" "1371.7" "1463.6" "1414.9" "1341.6" "524.6" "" "" "" "" "" "" "" "" "" "" "891.2" "736.3" "765.1" "615.4" "626.7" "702.2" "680.5" "635.2" "727.9" "524.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4481377694352566724" "False" "High" "IsMasterProtein" "P15121" "Aldo-keto reductase family 1 member B1 OS=Homo sapiens OX=9606 GN=AKR1B1 PE=1 SV=3" "0.000" "False" "43.166" "25" "10" "56" "10" "316" "35.8" "6.98" "165.85" "10" "other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus" "other molecular function" "Pf00248" "231" "ENSG00000085662" "AKR1B1" "B2R8N3; hsa:231; P15121; Q5U031; Q6FGA4; Q6ICP2; Q9BS21; Q9UCI9" "Eicosanoid metabolism via cyclooxygenases (COX); Disorders of galactose metabolism ; Omega-6-fatty acids in senescence; Polyol pathway; Metapathway biotransformation Phase I and II" "Pregnenolone biosynthesis; Fructose biosynthesis" "7" "0" "0.986" "0.962" "1.003" "0.946" "1.031" "0.937" "1.019" "1.017" "0.660" "5380.4" "5306.9" "5177.0" "5393.8" "5091.8" "5549.3" "5040.4" "5481.2" "5472.7" "3549.1" "" "" "" "" "" "" "" "" "" "" "3219.8" "2757.8" "2866.9" "2532.3" "2360.2" "2840.8" "2343.7" "2460.7" "2969.2" "3549.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4004494409327660908" "False" "High" "IsMasterProtein" "P07205" "Phosphoglycerate kinase 2 OS=Homo sapiens OX=9606 GN=PGK2 PE=1 SV=3" "0.000" "False" "42.710" "15" "6" "42" "1" "417" "44.8" "8.54" "120.93" "6" "other metabolic processes;other biological processes" "cytosol;cytoskeleton" "kinase activity;other molecular function" "Pf00162" "5232" "ENSG00000170950" "PGK2" "B2R6Y8; hsa:5232; P07205; Q9H107" "Cori cycle; Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis" "6" "0" "0.750" "0.802" "0.693" "0.766" "0.839" "0.664" "0.675" "0.748" "0.573" "421.7" "316.3" "338.4" "292.4" "322.9" "353.9" "280.1" "284.5" "315.3" "241.8" "" "" "" "" "" "" "" "" "" "" "252.4" "164.4" "187.4" "137.3" "149.7" "181.2" "130.2" "127.7" "171.1" "241.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-938207872866175487" "False" "High" "IsMasterProtein" "Q00534" "Cyclin-dependent kinase 6 OS=Homo sapiens OX=9606 GN=CDK6 PE=1 SV=1" "0.000" "False" "42.698" "33" "9" "17" "8" "326" "36.9" "6.46" "51.44" "9" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1021" "ENSG00000105810" "CDK6" "A4D1G0; hsa:1021; Q00534" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Metastatic brain tumor; Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Wnt signaling pathway; PI3K-Akt signaling pathway; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Influence of laminopathies on Wnt signaling; DYRK1A involvement regarding cell proliferation in brain development; DNA damage response" "Oxidative Stress Induced Senescence; Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Senescence-Associated Secretory Phenotype (SASP); Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Drug-mediated inhibition of CDK4/CDK6 activity; Regulation of RUNX1 Expression and Activity" "30" "1" "1.027" "0.975" "1.029" "0.995" "0.991" "1.042" "0.950" "1.010" "1.130" "1416.5" "1455.1" "1380.7" "1458.1" "1408.8" "1403.2" "1476.3" "1345.9" "1430.4" "1600.9" "" "" "" "" "" "" "" "" "" "" "847.7" "756.2" "764.6" "684.6" "653.0" "718.3" "686.5" "604.2" "776.1" "1600.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5656717572997732758" "False" "High" "IsMasterProtein" "P30566" "Adenylosuccinate lyase OS=Homo sapiens OX=9606 GN=ADSL PE=1 SV=2" "0.000" "False" "42.678" "15" "8" "32" "8" "484" "54.9" "7.11" "86.91" "8" "other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00206, Pf10397" "158" "ENSG00000239900" "ADSL" "B0QY76; hsa:158; O75495; P30566; Q5TI34" "" "Purine ribonucleoside monophosphate biosynthesis" "1" "0" "0.952" "0.881" "0.910" "0.975" "0.959" "0.912" "0.909" "0.907" "0.540" "1591.7" "1515.8" "1403.0" "1447.7" "1552.3" "1525.8" "1450.9" "1446.8" "1444.1" "859.0" "" "" "" "" "" "" "" "" "" "" "952.5" "787.7" "777.0" "679.6" "719.5" "781.1" "674.6" "649.5" "783.5" "859.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3599424746602695209" "False" "High" "IsMasterProtein" "Q9ULE6" "Paladin OS=Homo sapiens OX=9606 GN=PALD1 PE=1 SV=3" "0.000" "False" "42.676" "16" "12" "15" "12" "856" "96.7" "6.54" "44.61" "12" "" "cytosol;other cell component" "other molecular function" "Pf14566" "27143" "ENSG00000107719" "PALD1" "B2RMS1; B9EGC6; hsa:27143; Q5JTK7; Q5JTK8; Q9ULE6" "" "" "0" "0" "0.931" "0.962" "0.946" "1.065" "1.076" "0.987" "0.873" "0.963" "1.038" "641.8" "597.8" "617.5" "607.2" "683.4" "690.9" "633.6" "560.3" "617.9" "666.1" "" "" "" "" "" "" "" "" "" "" "384.1" "310.7" "342.0" "285.1" "316.8" "353.7" "294.6" "251.5" "335.3" "666.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7515792609303095651" "False" "High" "IsMasterProtein" "P61204" "ADP-ribosylation factor 3 OS=Homo sapiens OX=9606 GN=ARF3 PE=1 SV=2" "0.000" "False" "42.671" "42" "6" "42" "3" "181" "20.6" "7.43" "105.09" "6" "transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00025" "377" "ENSG00000134287" "ARF3" "A8K6G8; B7ZB63; hsa:377; P16587; P61204" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Synthesis of PIPs at the Golgi membrane" "3" "3" "0.898" "0.834" "0.894" "1.060" "1.008" "1.329" "0.976" "1.306" "0.815" "1530.8" "1375.4" "1276.2" "1368.0" "1623.3" "1543.5" "2034.7" "1494.8" "1998.5" "1248.2" "" "" "" "" "" "" "" "" "" "" "916.1" "714.8" "706.7" "642.2" "752.5" "790.2" "946.1" "671.1" "1084.3" "1248.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9120785921578449656" "False" "High" "IsMasterProtein" "A0A0B4J2D5" "Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial OS=Homo sapiens OX=9606 GN=GATD3B PE=5 SV=1" "0.000" "False" "42.618" "23" "6" "28" "6" "268" "28.1" "8.27" "82.82" "6" "" "mitochondrion" "" "" "8209" "" "GATD3B" "A0A0B4J2D5; A6NFJ6; A6NJY7; hsa:8209; O00650; O00660; O15011; O15012; P30042; P55346; P78474; Q92505; Q92507" "Gastric cancer network 1" "" "1" "0" "1.029" "1.040" "0.984" "0.921" "1.008" "0.916" "0.998" "0.939" "0.521" "1859.6" "1913.9" "1934.8" "1830.3" "1713.4" "1874.3" "1703.2" "1855.8" "1745.8" "968.8" "" "" "" "" "" "" "" "" "" "" "1112.8" "994.6" "1071.5" "859.3" "794.2" "959.5" "791.9" "833.2" "947.2" "968.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8133937274084103067" "False" "High" "IsMasterProtein" "P28074" "Proteasome subunit beta type-5 OS=Homo sapiens OX=9606 GN=PSMB5 PE=1 SV=3" "0.000" "False" "42.584" "29" "8" "32" "8" "263" "28.5" "6.92" "85.34" "8" "protein metabolism;other metabolic processes;stress response" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00227" "5693" "ENSG00000100804" "PSMB5" "B2R4N9; B4DUM9; D3DS43; E9PAV2; hsa:5693; P28074; Q16242; Q6PEW2; Q7Z3B5; Q86T01; Q9TNN9" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; ER-Phagosome pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.994" "1.027" "1.006" "1.031" "1.075" "0.970" "1.146" "1.135" "0.628" "1940.5" "1929.0" "1992.9" "1952.6" "2000.4" "2085.3" "1882.5" "2223.2" "2203.0" "1219.5" "" "" "" "" "" "" "" "" "" "" "1161.3" "1002.4" "1103.6" "916.7" "927.2" "1067.5" "875.3" "998.1" "1195.2" "1219.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4804495115062908755" "False" "High" "IsMasterProtein" "P41252" "Isoleucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=IARS1 PE=1 SV=2" "0.000" "False" "42.553" "11" "11" "17" "11" "1262" "144.4" "6.15" "37.54" "11" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00133, Pf08264, Pf19302" "3376" "ENSG00000196305; ENSG00000291356" "IARS1" "A8KAE9; hsa:3376; P41252; Q5TCD0; Q7Z3T4; Q9H588" "Amino acid metabolism" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "3" "0" "1.138" "1.140" "1.212" "1.357" "1.144" "1.167" "0.860" "1.146" "5.293" "252.3" "287.0" "287.5" "305.7" "342.4" "288.7" "294.4" "217.1" "289.1" "1335.4" "" "" "" "" "" "" "" "" "" "" "151.0" "149.1" "159.2" "143.5" "158.7" "147.8" "136.9" "97.4" "156.8" "1335.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4007751392279359432" "False" "High" "IsMasterProtein" "Q562R1" "Beta-actin-like protein 2 OS=Homo sapiens OX=9606 GN=ACTBL2 PE=1 SV=2" "0.000" "False" "42.526" "20" "7" "197" "2" "376" "42.0" "5.59" "490.21" "7" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "345651" "ENSG00000169067" "ACTBL2" "B2RPJ1; hsa:345651; Q562R1; Q562R2; Q562S9; Q562X8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5866289401045489846" "False" "High" "IsMasterProtein" "Q92616" "Stalled ribosome sensor GCN1 OS=Homo sapiens OX=9606 GN=GCN1 PE=1 SV=7" "0.000" "False" "42.482" "6" "15" "15" "15" "2671" "292.5" "7.43" "28.40" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function" "" "10985" "ENSG00000089154" "GCN1" "A8KAY1; hsa:10985; O95001; O95651; Q6P2S3; Q86X65; Q8N5I5; Q8WU80; Q92616; Q99736; Q9UE60" "" "Response of EIF2AK4 (GCN2) to amino acid deficiency" "1" "0" "0.783" "1.064" "0.895" "1.065" "0.897" "1.100" "0.702" "0.853" "5.697" "77.3" "60.5" "82.2" "69.2" "82.3" "69.3" "85.0" "54.2" "65.9" "440.2" "" "" "" "" "" "" "" "" "" "" "46.2" "31.4" "45.5" "32.5" "38.2" "35.5" "39.5" "24.3" "35.8" "440.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1718244645714628913" "False" "High" "IsMasterProtein" "Q9UIA9" "Exportin-7 OS=Homo sapiens OX=9606 GN=XPO7 PE=1 SV=3" "0.000" "False" "42.195" "10" "11" "19" "11" "1087" "123.8" "6.32" "53.32" "11" "transport" "nucleus;other cell component" "other molecular function" "Pf03810" "23039" "ENSG00000130227" "XPO7" "hsa:23039; O94846; Q6PJK9; Q8NEK7; Q9UIA9" "" "" "0" "0" "1.161" "1.180" "1.233" "1.259" "1.193" "1.068" "1.055" "1.197" "1.952" "554.2" "643.2" "653.9" "683.1" "697.8" "661.4" "591.7" "584.6" "663.4" "1081.7" "" "" "" "" "" "" "" "" "" "" "331.7" "334.3" "362.1" "320.7" "323.4" "338.6" "275.1" "262.5" "359.9" "1081.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-915816600694735360" "False" "High" "IsMasterProtein" "O14980" "Exportin-1 OS=Homo sapiens OX=9606 GN=XPO1 PE=1 SV=1" "0.000" "False" "42.098" "13" "14" "22" "14" "1071" "123.3" "6.06" "50.30" "14" "other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf08767, Pf18777, Pf18784, Pf18787" "7514" "ENSG00000082898" "XPO1" "A6NL14; A8K1K5; D6W5E2; hsa:7514; O14980; Q63HP8; Q68CP3; Q99433" "eIF5A regulation in response to inhibition of the nuclear export system; 22q11.2 copy number variation syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; MAPK6/MAPK4 signaling; NPAS4 regulates expression of target genes; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Heme signaling; Deactivation of the beta-catenin transactivating complex; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Downregulation of TGF-beta receptor signaling; HuR (ELAVL1) binds and stabilizes mRNA; Cyclin A/B1/B2 associated events during G2/M transition; Maturation of hRSV A proteins" "19" "0" "1.026" "1.109" "1.217" "1.143" "1.158" "1.162" "0.582" "1.138" "8.523" "342.7" "351.5" "380.0" "417.2" "391.6" "396.9" "398.2" "199.5" "389.9" "2920.8" "" "" "" "" "" "" "" "" "" "" "205.1" "182.6" "210.4" "195.9" "181.5" "203.2" "185.1" "89.6" "211.5" "2920.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604627173476332081" "False" "High" "IsMasterProtein" "O75534" "Cold shock domain-containing protein E1 OS=Homo sapiens OX=9606 GN=CSDE1 PE=1 SV=2" "0.000" "False" "42.062" "17" "13" "19" "13" "798" "88.8" "6.25" "36.90" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "nucleic acid binding activity" "Pf00313, Pf12901" "7812" "ENSG00000009307" "CSDE1" "A8K281; E9PGZ0; G5E9Q2; hsa:7812; O75534; O94961; Q5TF04; Q5TF05; Q68DF1; Q68DI9; Q9Y2S4" "" "" "0" "0" "0.998" "0.864" "1.056" "1.061" "0.947" "1.069" "0.470" "1.025" "7.345" "282.5" "282.0" "244.1" "298.3" "299.9" "267.7" "301.9" "132.9" "289.6" "2075.2" "" "" "" "" "" "" "" "" "" "" "169.1" "146.5" "135.2" "140.0" "139.0" "137.0" "140.4" "59.7" "157.1" "2075.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1870726190365747871" "False" "High" "IsMasterProtein" "P61160" "Actin-related protein 2 OS=Homo sapiens OX=9606 GN=ACTR2 PE=1 SV=1" "0.000" "False" "42.031" "24" "8" "31" "8" "394" "44.7" "6.74" "92.73" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "10097" "ENSG00000138071" "ACTR2" "B2RCP5; D6W5F4; E9PF41; hsa:10097; O15142; P61160; Q96C82" "Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "8" "0" "0.913" "0.915" "0.867" "0.945" "0.914" "0.989" "0.911" "0.971" "0.671" "1753.0" "1600.0" "1604.0" "1520.1" "1656.3" "1601.5" "1734.6" "1597.5" "1701.4" "1176.0" "" "" "" "" "" "" "" "" "" "" "1049.1" "831.5" "888.3" "713.6" "767.7" "819.8" "806.5" "717.2" "923.1" "1176.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-515522588376759980" "False" "High" "IsMasterProtein" "O60506" "Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens OX=9606 GN=SYNCRIP PE=1 SV=2" "0.000" "False" "41.925" "17" "11" "37" "4" "623" "69.6" "8.59" "93.36" "11" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf18360" "10492" "ENSG00000135316" "SYNCRIP" "E1P501; E1P502; hsa:10492; O60506; Q53H05; Q5TCG2; Q5TCG3; Q8IW78; Q8N599; Q96LC1; Q96LC2; Q9Y583" "" "" "0" "5" "1.063" "1.109" "1.051" "1.123" "1.103" "1.029" "0.887" "1.109" "3.049" "2550.8" "2712.6" "2829.3" "2681.6" "2865.8" "2813.6" "2625.7" "2262.0" "2827.8" "7777.0" "" "" "" "" "" "" "" "" "" "" "1526.5" "1409.6" "1566.8" "1259.0" "1328.3" "1440.4" "1220.9" "1015.5" "1534.2" "7777.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9124965961007810906" "False" "High" "IsMasterProtein" "P11387" "DNA topoisomerase 1 OS=Homo sapiens OX=9606 GN=TOP1 PE=1 SV=2" "0.000" "False" "41.921" "15" "12" "20" "12" "765" "90.7" "9.31" "49.28" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf01028, Pf02919, Pf14370" "7150" "ENSG00000198900" "TOP1" "A8KA78; E1P5W3; hsa:7150; O43256; P11387; Q12855; Q12856; Q15610; Q5TFY3; Q9UJN0" "Ebola virus infection in host; 15q25 copy number variation" "SUMOylation of DNA replication proteins" "3" "0" "1.063" "1.094" "1.207" "1.102" "1.131" "1.057" "0.614" "1.072" "6.402" "452.4" "480.9" "494.9" "546.0" "498.5" "511.5" "478.1" "277.9" "484.8" "2896.4" "" "" "" "" "" "" "" "" "" "" "270.7" "249.9" "274.1" "256.3" "231.1" "261.8" "222.3" "124.8" "263.0" "2896.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7589685267009723312" "False" "High" "IsMasterProtein" "Q9H0D6" "5'-3' exoribonuclease 2 OS=Homo sapiens OX=9606 GN=XRN2 PE=1 SV=1" "0.000" "False" "41.873" "12" "10" "16" "10" "950" "108.5" "7.47" "34.46" "10" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03159, Pf17846" "22803" "ENSG00000088930" "XRN2" "hsa:22803; Q3L8N4; Q6KGZ9; Q9BQL1; Q9H0D6; Q9NTW0; Q9NXS6; Q9UL53" "mRNA processing" "Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis" "3" "0" "1.064" "0.854" "1.072" "1.077" "1.049" "1.104" "1.140" "1.043" "0.902" "340.7" "362.4" "290.8" "365.2" "367.0" "357.2" "376.2" "388.5" "355.4" "307.4" "" "" "" "" "" "" "" "" "" "" "203.9" "188.3" "161.1" "171.5" "170.1" "182.9" "174.9" "174.4" "192.8" "307.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4388967430464997560" "False" "High" "IsMasterProtein" "P43034" "Platelet-activating factor acetylhydrolase IB subunit beta OS=Homo sapiens OX=9606 GN=PAFAH1B1 PE=1 SV=2" "0.000" "False" "41.750" "24" "10" "30" "9" "410" "46.6" "7.37" "69.80" "10" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08513" "5048" "ENSG00000007168" "PAFAH1B1" "B2R7Q7; hsa:5048; P43034; Q8WZ88; Q8WZ89" "Wnt signaling pathway and pluripotency; Ciliary landscape; Neurogenesis regulation in the olfactory epithelium; PAFAH1B1 copy number variation" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "18" "1" "1.037" "1.003" "1.048" "1.061" "1.012" "0.918" "0.964" "0.970" "0.698" "1981.7" "2054.6" "1987.3" "2077.7" "2103.5" "2006.4" "1820.0" "1910.0" "1922.0" "1384.1" "" "" "" "" "" "" "" "" "" "" "1185.9" "1067.7" "1100.5" "975.4" "975.0" "1027.1" "846.3" "857.5" "1042.8" "1384.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5909350322516910922" "False" "High" "IsMasterProtein" "P40222" "Alpha-taxilin OS=Homo sapiens OX=9606 GN=TXLNA PE=1 SV=3" "0.000" "False" "41.721" "24" "11" "17" "11" "546" "61.9" "6.52" "42.34" "11" "transport;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf09728" "200081" "ENSG00000084652" "TXLNA" "D3DPP6; hsa:200081; P40222; Q5TFJ6; Q66K62; Q86T54; Q86T85; Q86T86; Q86Y86; Q86YW3; Q8N2Y3" "" "Other interleukin signaling" "1" "0" "1.008" "1.096" "1.014" "1.061" "1.090" "1.097" "1.062" "1.004" "1.146" "259.9" "262.1" "284.8" "263.5" "275.9" "283.4" "285.1" "276.1" "260.9" "298.0" "" "" "" "" "" "" "" "" "" "" "155.6" "136.2" "157.7" "123.7" "127.9" "145.1" "132.6" "123.9" "141.6" "298.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5215357132518723376" "False" "High" "IsMasterProtein" "P30040" "Endoplasmic reticulum resident protein 29 OS=Homo sapiens OX=9606 GN=ERP29 PE=1 SV=4" "0.000" "False" "41.701" "34" "7" "19" "7" "261" "29.0" "7.31" "47.66" "7" "protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf07749, Pf07912" "10961" "ENSG00000089248" "ERP29" "C9J183; hsa:10961; P30040; Q3MJC3; Q6FHT4" "" "" "0" "0" "1.002" "0.987" "0.891" "1.002" "0.998" "0.924" "0.948" "1.017" "0.859" "1738.1" "1740.9" "1715.9" "1549.5" "1741.5" "1734.2" "1605.4" "1648.1" "1767.0" "1493.8" "" "" "" "" "" "" "" "" "" "" "1040.2" "904.7" "950.2" "727.4" "807.2" "887.8" "746.5" "739.9" "958.6" "1493.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8904894331141024633" "False" "High" "IsMasterProtein" "Q04726" "Transducin-like enhancer protein 3 OS=Homo sapiens OX=9606 GN=TLE3 PE=1 SV=2" "0.000" "False" "41.655" "16" "11" "17" "11" "772" "83.4" "7.20" "38.29" "11" "cell-cell signaling;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf03920" "7090" "ENSG00000140332" "TLE3" "B4DPT0; E9PD64; F8W964; hsa:7090; Q04726; Q6PI57; Q8IVV6; Q8WVR2; Q9HCM5" "White fat cell differentiation" "Estrogen-dependent gene expression; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Repression of WNT target genes" "5" "0" "1.077" "0.988" "1.046" "1.083" "1.067" "1.041" "1.100" "1.012" "0.995" "855.1" "921.3" "844.7" "894.8" "926.3" "912.4" "890.2" "941.0" "865.4" "850.4" "" "" "" "" "" "" "" "" "" "" "511.7" "478.8" "467.8" "420.1" "429.3" "467.1" "413.9" "422.4" "469.5" "850.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8106811875095759613" "False" "High" "IsMasterProtein" "P06454" "Prothymosin alpha OS=Homo sapiens OX=9606 GN=PTMA PE=1 SV=2" "0.000" "False" "41.507" "14" "4" "82" "4" "111" "12.2" "3.78" "220.91" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf03247" "5757" "ENSG00000187514" "PTMA" "hsa:5757; P06454; Q15249; Q15592" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.902" "0.913" "0.891" "1.051" "0.923" "0.971" "1.043" "0.883" "0.376" "5452.1" "4917.0" "4977.5" "4856.0" "5729.5" "5034.1" "5295.9" "5686.8" "4811.6" "2049.7" "" "" "" "" "" "" "" "" "" "" "3262.8" "2555.2" "2756.5" "2279.7" "2655.7" "2577.1" "2462.5" "2553.0" "2610.5" "2049.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7622231560690593168" "False" "High" "IsMasterProtein" "Q13043" "Serine/threonine-protein kinase 4 OS=Homo sapiens OX=9606 GN=STK4 PE=1 SV=2" "0.000" "False" "41.256" "24" "11" "13" "11" "487" "55.6" "5.07" "40.24" "11" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf11629" "6789" "ENSG00000101109" "STK4" "B2RCR8; hsa:6789; Q13043; Q15802; Q4G156; Q5H982; Q6PD60; Q9BR32; Q9NTZ4" "MAPK signaling pathway; Ras signaling; Non-small cell lung cancer" "Signaling by Hippo" "4" "0" "0.939" "0.897" "0.909" "1.051" "1.138" "0.986" "1.019" "1.022" "1.173" "813.8" "764.0" "730.2" "739.8" "855.4" "926.2" "802.7" "829.1" "831.5" "954.6" "" "" "" "" "" "" "" "" "" "" "487.0" "397.0" "404.4" "347.3" "396.5" "474.1" "373.2" "372.2" "451.1" "954.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93138434393619496" "False" "High" "IsMasterProtein" "Q9NTI5" "Sister chromatid cohesion protein PDS5 homolog B OS=Homo sapiens OX=9606 GN=PDS5B PE=1 SV=1" "0.000" "False" "41.212" "9" "12" "14" "11" "1447" "164.6" "8.47" "36.47" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf20168" "23047" "ENSG00000083642" "PDS5B" "hsa:23047; Q5R3S3; Q5W0K8; Q6NSC3; Q8IXT6; Q9H5N8; Q9NTI5; Q9Y2I5; Q9Y451" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "6" "1" "1.072" "1.011" "1.025" "1.065" "1.010" "1.096" "0.554" "1.046" "5.468" "226.2" "242.6" "228.8" "232.0" "241.0" "228.4" "247.9" "125.3" "236.7" "1237.0" "" "" "" "" "" "" "" "" "" "" "135.4" "126.1" "126.7" "108.9" "111.7" "116.9" "115.3" "56.2" "128.4" "1237.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5272844491039920934" "False" "High" "IsMasterProtein" "P09661" "U2 small nuclear ribonucleoprotein A' OS=Homo sapiens OX=9606 GN=SNRPA1 PE=1 SV=2" "0.000" "False" "41.108" "21" "5" "24" "5" "255" "28.4" "8.62" "65.56" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf14580" "6627" "ENSG00000131876" "SNRPA1" "B2R5I6; hsa:6627; P09661; Q8TBD2" "mRNA processing" "mRNA Splicing - Major Pathway; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "3" "0" "1.049" "1.005" "1.070" "1.079" "0.986" "0.979" "1.004" "1.017" "0.806" "1216.2" "1276.0" "1222.6" "1301.3" "1312.5" "1199.8" "1191.0" "1221.5" "1236.8" "980.8" "" "" "" "" "" "" "" "" "" "" "727.8" "663.1" "677.0" "610.9" "608.4" "614.2" "553.8" "548.4" "671.0" "980.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4048246386295190521" "False" "High" "IsMasterProtein" "Q9Y6E0" "Serine/threonine-protein kinase 24 OS=Homo sapiens OX=9606 GN=STK24 PE=1 SV=1" "0.000" "False" "41.073" "21" "9" "12" "4" "443" "49.3" "5.69" "38.25" "9" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "8428" "ENSG00000102572" "STK24" "hsa:8428; O14840; Q5JV92; Q9Y6E0" "" "Apoptotic cleavage of cellular proteins" "2" "4" "1.033" "1.029" "0.939" "1.008" "1.124" "0.950" "1.056" "1.050" "1.332" "1315.5" "1359.5" "1353.5" "1235.4" "1326.0" "1479.0" "1249.3" "1388.6" "1381.4" "1752.4" "" "" "" "" "" "" "" "" "" "" "787.3" "706.5" "749.5" "580.0" "614.6" "757.1" "580.9" "623.4" "749.5" "1752.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3944775931209301438" "False" "High" "IsMasterProtein" "P60660" "Myosin light polypeptide 6 OS=Homo sapiens OX=9606 GN=MYL6 PE=1 SV=2" "0.000" "False" "41.050" "36" "5" "33" "3" "151" "16.9" "4.65" "84.22" "5" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "" "4637" "ENSG00000092841" "MYL6" "hsa:4637; P16475; P24572; P24573; P60660; Q12790; Q561V9; Q6IAZ0; Q6IPY5" "Ciliary landscape" "RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "8" "2" "0.965" "0.953" "0.961" "0.962" "0.944" "1.049" "0.928" "0.916" "1.110" "2792.9" "2694.6" "2660.4" "2683.0" "2687.3" "2637.6" "2929.3" "2592.1" "2558.3" "3099.5" "" "" "" "" "" "" "" "" "" "" "1671.4" "1400.3" "1473.3" "1259.6" "1245.6" "1350.2" "1362.0" "1163.7" "1388.0" "3099.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6985960340352969870" "False" "High" "IsMasterProtein" "P62714" "Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PPP2CB PE=1 SV=1" "0.000" "False" "41.017" "35" "9" "41" "1" "309" "35.6" "5.43" "101.29" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00149" "5516" "ENSG00000104695" "PPP2CB" "D3DSV4; hsa:5516; P11082; P62714; Q6FHK5" "Serotonin transporter activity; Dopamine metabolism; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; Exercise-induced circadian regulation; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; Monoamine transport" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RAF activation; Negative regulation of MAPK pathway; PKR-mediated signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "45" "0" "1.381" "1.079" "1.178" "1.193" "0.842" "1.237" "1.031" "0.990" "0.545" "58.5" "80.8" "63.1" "68.9" "69.8" "49.2" "72.4" "60.3" "57.9" "31.9" "" "" "" "" "" "" "" "" "" "" "35.0" "42.0" "35.0" "32.4" "32.3" "25.2" "33.7" "27.1" "31.4" "31.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8059296943260836861" "False" "High" "IsMasterProtein" "Q15286" "Ras-related protein Rab-35 OS=Homo sapiens OX=9606 GN=RAB35 PE=1 SV=1" "0.000" "False" "40.917" "35" "6" "33" "4" "201" "23.0" "8.29" "85.32" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "11021" "ENSG00000111737" "RAB35" "B2R6E0; B4E390; hsa:11021; Q15286" "" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; TBC/RABGAPs" "3" "0" "1.162" "1.079" "0.946" "0.928" "1.014" "0.990" "1.094" "1.077" "0.627" "455.4" "529.1" "491.4" "430.9" "422.9" "461.7" "450.7" "498.2" "490.6" "285.4" "" "" "" "" "" "" "" "" "" "" "272.6" "274.9" "272.1" "202.3" "196.0" "236.4" "209.6" "223.7" "266.2" "285.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-92542688516821267" "False" "High" "IsMasterProtein" "Q14699" "Raftlin OS=Homo sapiens OX=9606 GN=RFTN1 PE=1 SV=4" "0.000" "False" "40.883" "24" "14" "27" "14" "578" "63.1" "5.67" "65.83" "14" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "nucleic acid binding activity" "Pf15250" "23180" "ENSG00000131378" "RFTN1" "hsa:23180; Q0D2G0; Q14699; Q496Y2; Q4QQI7; Q5JB48; Q7Z7P2" "" "" "0" "0" "1.033" "1.009" "0.995" "1.076" "1.045" "0.948" "1.032" "1.102" "0.857" "696.5" "719.6" "703.0" "693.3" "749.1" "727.9" "660.3" "719.1" "767.5" "596.6" "" "" "" "" "" "" "" "" "" "" "416.8" "374.0" "389.3" "325.5" "347.2" "372.6" "307.0" "322.8" "416.4" "596.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8293533738236197165" "False" "High" "IsMasterProtein" "O75347" "Tubulin-specific chaperone A OS=Homo sapiens OX=9606 GN=TBCA PE=1 SV=3" "0.000" "False" "40.861" "43" "6" "63" "6" "108" "12.8" "5.29" "182.62" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02970" "6902" "ENSG00000171530" "TBCA" "B4DT30; hsa:6902; O75347" "VEGFA-VEGFR2 signaling" "Post-chaperonin tubulin folding pathway" "2" "0" "0.996" "0.995" "0.920" "0.996" "0.999" "0.965" "1.077" "0.916" "0.382" "5932.4" "5909.6" "5901.1" "5458.4" "5909.2" "5926.6" "5723.2" "6389.3" "5435.3" "2264.3" "" "" "" "" "" "" "" "" "" "" "3550.2" "3071.0" "3267.9" "2562.6" "2739.0" "3034.0" "2661.1" "2868.4" "2948.9" "2264.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4191413839330820481" "False" "High" "IsMasterProtein" "O14979" "Heterogeneous nuclear ribonucleoprotein D-like OS=Homo sapiens OX=9606 GN=HNRNPDL PE=1 SV=3" "0.000" "False" "40.825" "21" "9" "37" "8" "420" "46.4" "9.57" "83.09" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf00076" "9987" "ENSG00000152795" "HNRNPDL" "hsa:9987; O14979; Q6SPF2; Q7KZ74; Q7KZ75; Q96IM0; Q96S43" "" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "1" "0" "0.934" "0.970" "0.870" "1.048" "1.035" "0.979" "1.075" "0.972" "0.565" "2080.9" "1943.9" "2018.6" "1810.1" "2181.2" "2153.1" "2037.8" "2237.9" "2022.3" "1175.4" "" "" "" "" "" "" "" "" "" "" "1245.3" "1010.2" "1117.9" "849.8" "1011.0" "1102.2" "947.5" "1004.7" "1097.2" "1175.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5545156882891984968" "False" "High" "IsMasterProtein" "P07954" "Fumarate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=FH PE=1 SV=3" "0.000" "False" "40.820" "15" "8" "18" "8" "510" "54.6" "8.76" "55.91" "8" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00206, Pf10415" "2271" "ENSG00000091483" "FH" "B1ANK7; hsa:2271; P07954" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Krebs cycle disorders; Type 2 papillary renal cell carcinoma; Metabolic reprogramming in colon cancer; TCA cycle in senescence; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "9" "0" "1.029" "0.901" "1.002" "0.933" "0.967" "1.037" "0.995" "0.956" "0.949" "1800.9" "1852.8" "1621.9" "1804.8" "1680.5" "1741.9" "1867.6" "1792.3" "1722.1" "1709.7" "" "" "" "" "" "" "" "" "" "" "1077.7" "962.9" "898.2" "847.3" "778.9" "891.7" "868.4" "804.6" "934.3" "1709.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8024352083789976777" "False" "High" "IsMasterProtein" "Q9UKV3" "Apoptotic chromatin condensation inducer in the nucleus OS=Homo sapiens OX=9606 GN=ACIN1 PE=1 SV=2" "0.000" "False" "40.777" "8" "10" "16" "10" "1341" "151.8" "6.43" "51.86" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf16294" "22985" "ENSG00000100813" "ACIN1" "B2RTT4; D3DS45; hsa:22985; O75158; Q9UG91; Q9UKV1; Q9UKV2; Q9UKV3" "" "mRNA Splicing - Major Pathway; Apoptotic cleavage of cellular proteins" "2" "0" "1.046" "0.989" "0.916" "0.985" "0.951" "1.050" "1.077" "0.992" "0.441" "930.0" "972.6" "919.6" "851.9" "915.7" "884.6" "976.3" "1001.9" "922.5" "410.0" "" "" "" "" "" "" "" "" "" "" "556.6" "505.4" "509.2" "399.9" "424.4" "452.8" "454.0" "449.8" "500.5" "410.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6077570543552496726" "False" "High" "IsMasterProtein" "Q8N1G4" "Leucine-rich repeat-containing protein 47 OS=Homo sapiens OX=9606 GN=LRRC47 PE=1 SV=1" "0.000" "False" "40.660" "17" "9" "20" "9" "583" "63.4" "8.28" "53.86" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00560, Pf13855" "57470" "ENSG00000130764" "LRRC47" "hsa:57470; Q8N1G4; Q9ULN5" "" "" "0" "0" "1.002" "0.897" "1.007" "1.088" "0.959" "0.984" "0.989" "1.004" "0.936" "911.2" "912.9" "817.6" "917.1" "991.6" "873.8" "896.4" "900.8" "915.1" "853.1" "" "" "" "" "" "" "" "" "" "" "545.3" "474.4" "452.8" "430.6" "459.6" "447.3" "416.8" "404.4" "496.5" "853.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1051331415144919391" "False" "High" "IsMasterProtein" "P49189" "4-trimethylaminobutyraldehyde dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH9A1 PE=1 SV=3" "0.000" "False" "40.571" "27" "12" "29" "12" "494" "53.8" "5.87" "63.13" "12" "cell organization and biogenesis;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00171" "223" "ENSG00000143149" "ALDH9A1" "B2R6X1; B4DXY7; B9EKV4; hsa:223; P49189; Q5VV90; Q6LCL1; Q9NZT7" "GABA receptor signaling; Fluoroacetic acid toxicity; Opioid receptor pathways" "Carnitine synthesis" "4" "0" "0.952" "0.941" "1.037" "0.999" "0.922" "0.966" "0.937" "0.978" "0.551" "1096.3" "1043.4" "1032.1" "1136.8" "1095.3" "1010.3" "1058.7" "1027.7" "1072.6" "604.0" "" "" "" "" "" "" "" "" "" "" "656.1" "542.2" "571.5" "533.7" "507.7" "517.2" "492.3" "461.4" "581.9" "604.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5341813448089902722" "False" "High" "IsMasterProtein" "P16885" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 OS=Homo sapiens OX=9606 GN=PLCG2 PE=1 SV=4" "0.000" "False" "40.551" "12" "15" "20" "15" "1265" "147.8" "6.64" "49.48" "15" "cell-cell signaling;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00017, Pf00018, Pf00168, Pf00387, Pf00388, Pf16457" "5336" "ENSG00000197943" "PLCG2" "D3DUL3; hsa:5336; P16885; Q3ZTS2; Q59H45; Q969T5" "Leptin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; Microglia pathogen phagocytosis pathway; GPR40 pathway; Ras signaling; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; EGFR tyrosine kinase inhibitor resistance; GDNF signaling; 2q13 copy number variation syndrome; ErbB signaling pathway" "Generation of second messenger molecules; Role of phospholipids in phagocytosis; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; CLEC7A (Dectin-1) signaling; Toll Like Receptor 4 (TLR4) Cascade; GPVI-mediated activation cascade; DAP12 signaling; Synthesis of IP3 and IP4 in the cytosol; Signaling by CSF1 (M-CSF) in myeloid cells; Erythropoietin activates Phospholipase C gamma (PLCG); Dectin-2 family" "30" "0" "0.970" "1.040" "1.143" "1.295" "1.191" "1.137" "0.374" "1.157" "9.679" "255.5" "247.8" "265.7" "291.9" "330.9" "304.3" "290.4" "95.7" "295.5" "2472.8" "" "" "" "" "" "" "" "" "" "" "152.9" "128.8" "147.2" "137.1" "153.4" "155.8" "135.0" "42.9" "160.3" "2472.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6056072514061180880" "False" "High" "IsMasterProtein" "Q9Y2D5" "PALM2-AKAP2 fusion protein OS=Homo sapiens OX=9606 GN=PALM2AKAP2 PE=1 SV=4" "0.000" "False" "40.534" "10" "10" "18" "10" "1103" "122.0" "5.06" "44.65" "10" "" "plasma membrane;other membranes" "" "Pf03285, Pf15304" "445815" "ENSG00000157654" "PALM2AKAP2" "A9Z1X9; B1ALX9; B2RTU4; B3KQ00; B4DTZ2; B7ZW07; B9EJB5; hsa:445815; Q8IXS6; Q8N9D5; Q96DU1; Q9UG26; Q9Y2D5" "" "" "0" "0" "1.020" "0.984" "1.027" "1.003" "0.957" "1.034" "1.088" "1.029" "0.531" "584.2" "596.0" "575.0" "600.1" "586.0" "558.9" "604.1" "635.4" "601.1" "310.1" "" "" "" "" "" "" "" "" "" "" "349.6" "309.7" "318.4" "281.7" "271.6" "286.1" "280.9" "285.2" "326.1" "310.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8386790215885090291" "False" "High" "IsMasterProtein" "Q8N3X1" "Formin-binding protein 4 OS=Homo sapiens OX=9606 GN=FNBP4 PE=1 SV=3" "0.000" "False" "40.452" "10" "8" "14" "8" "1017" "110.2" "4.74" "42.87" "8" "" "nucleus" "" "Pf00397" "23360" "ENSG00000109920; ENSG00000285182" "FNBP4" "hsa:23360; Q8N3X1; Q9H985; Q9NT81; Q9Y2L7" "" "" "0" "0" "1.053" "0.945" "1.065" "1.044" "0.986" "1.004" "1.035" "0.948" "0.335" "724.9" "763.7" "684.8" "771.9" "756.8" "714.6" "727.5" "750.0" "687.2" "242.6" "" "" "" "" "" "" "" "" "" "" "433.8" "396.8" "379.2" "362.4" "350.8" "365.8" "338.3" "336.7" "372.8" "242.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "217416082876923675" "False" "High" "IsMasterProtein" "O75410" "Transforming acidic coiled-coil-containing protein 1 OS=Homo sapiens OX=9606 GN=TACC1 PE=1 SV=2" "0.000" "False" "40.433" "19" "13" "13" "11" "805" "87.7" "4.88" "28.42" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05010" "6867" "ENSG00000147526" "TACC1" "B2RBD9; B4E302; D3DSX6; hsa:6867; O75410; Q6Y687; Q86YG7; Q8IUJ2; Q8IUJ3; Q8IUJ4; Q8IZG2; Q8NEY7; Q9UPP9" "" "" "0" "0" "1.058" "1.019" "1.097" "1.112" "1.060" "1.250" "1.289" "1.236" "0.867" "296.3" "313.4" "302.1" "325.1" "329.5" "313.9" "370.2" "382.0" "366.2" "256.8" "" "" "" "" "" "" "" "" "" "" "177.3" "162.9" "167.3" "152.6" "152.7" "160.7" "172.1" "171.5" "198.7" "256.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4157182932771800811" "False" "High" "IsMasterProtein" "Q07955" "Serine/arginine-rich splicing factor 1 OS=Homo sapiens OX=9606 GN=SRSF1 PE=1 SV=2" "0.000" "False" "40.427" "33" "8" "26" "8" "248" "27.7" "10.36" "64.17" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6426" "ENSG00000136450" "SRSF1" "B2R6Z7; D3DTZ3; hsa:6426; Q07955; Q13809" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway" "7" "0" "0.915" "0.927" "0.928" "0.967" "0.877" "0.916" "0.958" "0.869" "0.424" "1495.9" "1369.2" "1387.4" "1387.9" "1446.9" "1311.6" "1369.5" "1432.8" "1300.1" "634.2" "" "" "" "" "" "" "" "" "" "" "895.2" "711.5" "768.3" "651.6" "670.6" "671.4" "636.8" "643.2" "705.4" "634.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2256235105362563928" "False" "High" "IsMasterProtein" "P62937" "Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens OX=9606 GN=PPIA PE=1 SV=2" "0.000" "False" "40.351" "41" "8" "127" "8" "165" "18.0" "7.81" "276.32" "8" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00160" "5478" "ENSG00000196262" "PPIA" "A8K220; hsa:5478; P05092; P62937; Q3KQW3; Q567Q0; Q6IBU5; Q96IX3; Q9BRU4; Q9BTY9; Q9UC61" "Prolactin signaling pathway" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Budding and maturation of HIV virion; Platelet degranulation ; Basigin interactions; SARS-CoV-1 activates/modulates innate immune responses; Integration of provirus; APOBEC3G mediated resistance to HIV-1 infection; Calcineurin activates NFAT; Binding and entry of HIV virion; Assembly Of The HIV Virion; Uncoating of the HIV Virion; Minus-strand DNA synthesis; Plus-strand DNA synthesis" "16" "0" "1.052" "1.177" "1.062" "1.074" "1.008" "1.008" "0.917" "1.021" "1.828" "6727.5" "7079.8" "7915.5" "7144.6" "7223.9" "6782.9" "6779.1" "6166.9" "6867.5" "12298.2" "" "" "" "" "" "" "" "" "" "" "4026.0" "3679.1" "4383.4" "3354.2" "3348.4" "3472.3" "3152.1" "2768.6" "3725.9" "12298.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6258947584785222358" "False" "High" "IsMasterProtein" "P62906" "Large ribosomal subunit protein uL1 OS=Homo sapiens OX=9606 GN=RPL10A PE=1 SV=2" "0.000" "False" "40.314" "37" "8" "42" "8" "217" "24.8" "9.94" "105.17" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00687" "4736" "ENSG00000198755" "RPL10A" "B2R801; hsa:4736; P52859; P53025; P62906; Q5TZT6; Q8J013" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.967" "0.982" "1.040" "0.941" "1.080" "0.906" "0.991" "1.019" "0.782" "1784.1" "1725.3" "1752.8" "1854.8" "1679.4" "1927.0" "1615.9" "1767.7" "1817.5" "1395.1" "" "" "" "" "" "" "" "" "" "" "1067.7" "896.6" "970.7" "870.8" "778.4" "986.5" "751.3" "793.6" "986.1" "1395.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3264120083815806641" "False" "High" "IsMasterProtein" "O14737" "Programmed cell death protein 5 OS=Homo sapiens OX=9606 GN=PDCD5 PE=1 SV=3" "0.000" "False" "40.229" "63" "8" "32" "8" "125" "14.3" "6.04" "73.80" "8" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf01984" "9141" "ENSG00000105185" "PDCD5" "B4DE64; hsa:9141; O14737; Q53YC9; Q6IB70" "" "" "0" "0" "0.958" "0.934" "0.971" "1.037" "0.911" "1.000" "0.980" "0.888" "0.519" "2008.1" "1923.4" "1874.7" "1950.3" "2081.8" "1829.0" "2008.2" "1967.0" "1782.9" "1041.8" "" "" "" "" "" "" "" "" "" "" "1201.8" "999.5" "1038.2" "915.6" "965.0" "936.3" "933.8" "883.1" "967.3" "1041.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-191513720103364216" "False" "High" "IsMasterProtein" "Q8TAA3" "Proteasome subunit alpha-type 8 OS=Homo sapiens OX=9606 GN=PSMA8 PE=1 SV=3" "0.000" "False" "40.206" "32" "8" "30" "5" "256" "28.5" "8.98" "91.31" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "" "Pf00227, Pf10584" "143471" "ENSG00000154611" "PSMA8" "B0YJ75; hsa:143471; Q8IVP4; Q8TA98; Q8TAA2; Q8TAA3" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; UCH proteinases; ER-Phagosome pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Cross-presentation of soluble exogenous antigens (endosomes); Regulation of ornithine decarboxylase (ODC)" "54" "0" "0.944" "0.972" "1.234" "1.023" "0.989" "1.130" "1.228" "1.046" "0.730" "452.1" "427.0" "439.6" "557.8" "462.6" "447.2" "511.0" "555.0" "473.0" "330.1" "" "" "" "" "" "" "" "" "" "" "270.6" "221.9" "243.4" "261.9" "214.4" "228.9" "237.6" "249.2" "256.6" "330.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7460100142715479081" "False" "High" "IsMasterProtein" "P09960" "Leukotriene A-4 hydrolase OS=Homo sapiens OX=9606 GN=LTA4H PE=1 SV=2" "0.000" "False" "40.201" "17" "11" "21" "11" "611" "69.2" "6.18" "52.08" "11" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01433, Pf09127, Pf17900" "4048" "ENSG00000111144" "LTA4H" "B4DNQ9; F8VV40; hsa:4048; P09960; Q6IAT6; Q9UCT7" "Eicosanoid metabolism via lipooxygenases (LOX); Prostaglandin and leukotriene metabolism in senescence ; Leukotriene metabolic pathway; Prostaglandin and leukotriene metabolism in senescence ; Omega-6-fatty acids in senescence" "Neutrophil degranulation; Biosynthesis of protectins; Synthesis of Leukotrienes (LT) and Eoxins (EX); Biosynthesis of D-series resolvins; Biosynthesis of E-series 18(S)-resolvins; Biosynthesis of aspirin-triggered D-series resolvins; Biosynthesis of E-series 18(R)-resolvins" "12" "0" "1.175" "1.238" "1.184" "1.098" "1.169" "1.009" "1.163" "1.100" "1.633" "844.7" "992.5" "1045.8" "1000.2" "927.9" "987.7" "852.7" "982.4" "928.9" "1379.9" "" "" "" "" "" "" "" "" "" "" "505.5" "515.8" "579.1" "469.6" "430.1" "505.6" "396.5" "441.0" "504.0" "1379.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6534553132144552728" "False" "High" "IsMasterProtein" "Q09028" "Histone-binding protein RBBP4 OS=Homo sapiens OX=9606 GN=RBBP4 PE=1 SV=3" "0.000" "False" "40.131" "25" "9" "28" "5" "425" "47.6" "4.89" "74.57" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "5928" "ENSG00000162521" "RBBP4" "B2R6G9; B4DRH0; D3DPQ3; hsa:5928; P31149; Q09028; Q53H02; Q96BV9" "Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; Effect of progerin on genes involved in progeria; Pleural mesothelioma; DYRK1A involvement regarding cell proliferation in brain development" "RNA Polymerase I Transcription Initiation; HCMV Early Events; Potential therapeutics for SARS; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PKMTs methylate histone lysines; G1/S-Specific Transcription; Regulation of TP53 Activity through Acetylation; Polo-like kinase mediated events; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "28" "0" "1.081" "1.118" "1.105" "1.058" "1.122" "1.011" "1.200" "1.088" "0.936" "1052.3" "1137.8" "1176.1" "1162.3" "1112.9" "1180.5" "1063.7" "1262.9" "1144.6" "985.1" "" "" "" "" "" "" "" "" "" "" "629.7" "591.3" "651.3" "545.7" "515.9" "604.3" "494.6" "567.0" "621.0" "985.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8197939441703168183" "False" "High" "IsMasterProtein" "Cont_P12763" "Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2" "0.000" "True" "40.118" "26" "7" "10" "7" "359" "38.4" "5.50" "34.75" "7" "stress response;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00031" "280988" "ENSBTAG00000000522" "AHSG" "A6QLF7; B0JYN6; bta:280988; P12763" "" "Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "4" "0" "1.344" "1.034" "1.300" "1.002" "1.062" "1.259" "1.085" "1.152" "1.009" "722.2" "970.5" "746.5" "938.9" "723.7" "766.8" "909.4" "783.5" "831.7" "728.5" "" "" "" "" "" "" "" "" "" "" "432.2" "504.3" "413.4" "440.8" "335.5" "392.5" "422.9" "351.8" "451.2" "728.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1824011876683044668" "False" "High" "IsMasterProtein" "Q9ULA0" "Aspartyl aminopeptidase OS=Homo sapiens OX=9606 GN=DNPEP PE=1 SV=2" "0.000" "False" "40.066" "22" "9" "15" "9" "485" "53.4" "7.58" "42.62" "9" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02127" "23549" "ENSG00000123992" "DNPEP" "hsa:23549; Q9BW44; Q9NUV5; Q9NV55; Q9ULA0" "Ciliary landscape" "" "1" "0" "0.986" "0.977" "0.955" "0.969" "0.987" "1.044" "0.932" "1.071" "0.663" "754.2" "743.8" "737.2" "720.1" "730.6" "744.1" "787.7" "702.8" "807.6" "500.3" "" "" "" "" "" "" "" "" "" "" "451.4" "386.5" "408.2" "338.1" "338.6" "380.9" "366.3" "315.5" "438.2" "500.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1414691960117410819" "False" "High" "IsMasterProtein" "P33991" "DNA replication licensing factor MCM4 OS=Homo sapiens OX=9606 GN=MCM4 PE=1 SV=5" "0.000" "False" "40.065" "15" "12" "14" "12" "863" "96.5" "6.74" "41.04" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855, Pf21128" "4173" "ENSG00000104738" "MCM4" "hsa:4173; P33991; Q8NEH1; Q99658" "Cell cycle; Gastric cancer network 1; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "12" "0" "1.175" "1.058" "1.286" "1.335" "1.319" "1.363" "1.166" "1.269" "4.707" "470.6" "553.1" "498.1" "605.1" "628.1" "620.6" "641.6" "548.9" "597.2" "2215.4" "" "" "" "" "" "" "" "" "" "" "281.6" "287.4" "275.8" "284.1" "291.1" "317.7" "298.3" "246.4" "324.0" "2215.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4701772359172858038" "False" "High" "IsMasterProtein" "P49790" "Nuclear pore complex protein Nup153 OS=Homo sapiens OX=9606 GN=NUP153 PE=1 SV=2" "0.000" "False" "40.029" "7" "9" "12" "9" "1475" "153.8" "8.73" "36.83" "9" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00641, Pf08604, Pf10599" "9972" "ENSG00000124789" "NUP153" "B4DIK2; E7EPX5; F6QR24; hsa:9972; P49790; Q4LE47; Q5T9I7; Q7Z743" "TGF-beta signaling pathway" "Nuclear import of Rev protein; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; SUMOylation of DNA replication proteins; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "29" "0" "0.978" "0.960" "0.915" "0.980" "0.954" "0.984" "0.957" "1.031" "0.585" "318.6" "311.6" "305.8" "291.5" "312.3" "304.0" "313.4" "304.9" "328.5" "186.5" "" "" "" "" "" "" "" "" "" "" "190.7" "161.9" "169.3" "136.9" "144.7" "155.6" "145.7" "136.9" "178.2" "186.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3099345167640791747" "False" "High" "IsMasterProtein" "Q00796" "Sorbitol dehydrogenase OS=Homo sapiens OX=9606 GN=SORD PE=1 SV=4" "0.000" "False" "40.024" "23" "8" "24" "8" "357" "38.3" "7.97" "66.87" "8" "other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion" "other molecular function" "Pf00107, Pf08240" "6652" "ENSG00000140263" "SORD" "B2R655; B7Z3A6; hsa:6652; J3JZZ5; Q00796; Q16682; Q9UMD6" "Disorders of fructose metabolism; Polyol pathway" "Formation of xylulose-5-phosphate; Fructose biosynthesis" "4" "0" "0.927" "0.993" "1.019" "1.002" "0.934" "0.932" "1.055" "0.940" "0.554" "1308.9" "1213.0" "1299.9" "1333.6" "1311.9" "1222.9" "1219.7" "1380.6" "1230.3" "724.5" "" "" "" "" "" "" "" "" "" "" "783.3" "630.3" "719.8" "626.1" "608.1" "626.1" "567.1" "619.8" "667.5" "724.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3614500297026839647" "False" "High" "IsMasterProtein" "Q9Y266" "Nuclear migration protein nudC OS=Homo sapiens OX=9606 GN=NUDC PE=1 SV=1" "0.000" "False" "40.012" "25" "9" "17" "9" "331" "38.2" "5.38" "47.54" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04969, Pf14050, Pf16273" "10726" "ENSG00000090273" "NUDC" "hsa:10726; Q5QP31; Q5QP35; Q9H0N2; Q9Y266; Q9Y2B6" "Ciliary landscape; PAFAH1B1 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; RND2 GTPase cycle; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "9" "0" "1.137" "1.112" "1.087" "1.129" "1.008" "1.238" "1.041" "1.169" "1.933" "1120.9" "1274.0" "1246.5" "1219.0" "1265.4" "1129.6" "1388.2" "1167.2" "1310.7" "2167.1" "" "" "" "" "" "" "" "" "" "" "670.8" "662.1" "690.3" "572.3" "586.5" "578.3" "645.5" "524.0" "711.1" "2167.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-911764670660096816" "False" "High" "IsMasterProtein" "P08195" "Amino acid transporter heavy chain SLC3A2 OS=Homo sapiens OX=9606 GN=SLC3A2 PE=1 SV=3" "0.000" "False" "40.005" "11" "6" "16" "6" "630" "68.0" "5.01" "48.67" "6" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;nucleic acid binding activity;other molecular function" "Pf00128, Pf16028" "6520" "ENSG00000168003" "SLC3A2" "hsa:6520; J3KPF3; P08195; Q13543" "mRNA, protein, and metabolite inducation pathway by cyclosporin A; Ferroptosis; Proximal tubule transport; Pleural mesothelioma" "Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane; Defective SLC7A7 causes lysinuric protein intolerance (LPI)" "8" "0" "1.105" "0.994" "1.038" "1.009" "1.003" "1.079" "1.263" "1.114" "0.467" "623.5" "688.9" "619.7" "646.9" "629.4" "625.4" "672.4" "787.6" "694.6" "291.0" "" "" "" "" "" "" "" "" "" "" "373.1" "358.0" "343.2" "303.7" "291.7" "320.2" "312.7" "353.6" "376.8" "291.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1477701677307109055" "False" "High" "IsMasterProtein" "P27694" "Replication protein A 70 kDa DNA-binding subunit OS=Homo sapiens OX=9606 GN=RPA1 PE=1 SV=2" "0.000" "False" "39.978" "18" "10" "13" "10" "616" "68.1" "7.21" "32.85" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01336, Pf04057, Pf08646, Pf16900" "6117" "ENSG00000132383" "RPA1" "A8K0Y9; hsa:6117; P27694; Q59ES9" "Homologous recombination; Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "SUMOylation of DNA damage response and repair proteins; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Meiotic recombination; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "38" "0" "1.053" "1.127" "1.017" "1.109" "1.116" "1.398" "1.507" "1.589" "3.391" "462.4" "486.8" "521.0" "470.3" "512.8" "515.9" "646.4" "697.1" "734.8" "1568.1" "" "" "" "" "" "" "" "" "" "" "276.7" "253.0" "288.5" "220.8" "237.7" "264.1" "300.6" "312.9" "398.6" "1568.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4594033010686828793" "False" "High" "IsMasterProtein" "P48637" "Glutathione synthetase OS=Homo sapiens OX=9606 GN=GSS PE=1 SV=1" "0.000" "False" "39.953" "28" "14" "39" "14" "474" "52.4" "5.92" "94.16" "14" "other metabolic processes;stress response;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf03199, Pf03917" "2937" "ENSG00000100983" "GSS" "B2R697; B6F210; E1P5P9; hsa:2937; P48637; Q4TTD9" "Glutathione metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways; Ferroptosis; Metapathway biotransformation Phase I and II" "Glutathione synthesis and recycling; Defective GSS causes GSS deficiency" "8" "0" "0.961" "0.949" "0.959" "0.951" "0.918" "0.946" "0.944" "0.969" "0.489" "3010.1" "2892.5" "2857.0" "2885.8" "2861.9" "2763.8" "2848.2" "2840.8" "2916.8" "1472.1" "" "" "" "" "" "" "" "" "" "" "1801.4" "1503.1" "1582.1" "1354.8" "1326.5" "1414.9" "1324.3" "1275.3" "1582.5" "1472.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7238306351176714360" "False" "High" "IsMasterProtein" "Q14974" "Importin subunit beta-1 OS=Homo sapiens OX=9606 GN=KPNB1 PE=1 SV=2" "0.000" "False" "39.938" "13" "9" "17" "9" "876" "97.1" "4.78" "42.83" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00514, Pf03810" "3837" "ENSG00000108424" "KPNB1" "B7ZAV6; D3DTT3; hsa:3837; Q14637; Q14974; Q53XN2; Q96J27" "Sterol regulatory element-binding proteins (SREBP) signaling; 22q11.2 copy number variation syndrome" "Neutrophil degranulation; Assembly of the ORC complex at the origin of replication; Apoptosis induced DNA fragmentation; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation; Interferon alpha/beta signaling; Regulation of cholesterol biosynthesis by SREBP (SREBF); SARS-CoV-1 activates/modulates innate immune responses; Initiation of Nuclear Envelope (NE) Reformation; Inhibition of nitric oxide production" "15" "0" "1.154" "1.372" "1.191" "1.261" "1.185" "1.164" "0.802" "1.227" "5.695" "258.2" "298.0" "354.2" "307.5" "325.5" "306.0" "300.6" "207.0" "316.8" "1470.2" "" "" "" "" "" "" "" "" "" "" "154.5" "154.9" "196.2" "144.3" "150.9" "156.7" "139.8" "92.9" "171.9" "1470.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4968571585111953171" "False" "High" "IsMasterProtein" "P55036" "26S proteasome non-ATPase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMD4 PE=1 SV=1" "0.000" "False" "39.808" "23" "7" "29" "7" "377" "40.7" "4.79" "89.06" "7" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02809, Pf13519" "5710" "ENSG00000159352" "PSMD4" "D3DV16; hsa:5710; P55036; Q5VWC5; Q9NS92" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling; Alzheimer's disease" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; SCF(Skp2)-mediated degradation of p27/p21; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "1.046" "1.031" "1.057" "0.984" "1.002" "1.041" "1.057" "1.015" "0.711" "2342.7" "2449.5" "2415.5" "2475.4" "2306.3" "2346.4" "2438.4" "2475.1" "2378.6" "1666.7" "" "" "" "" "" "" "" "" "" "" "1402.0" "1272.9" "1337.7" "1162.2" "1069.0" "1201.2" "1133.8" "1111.2" "1290.5" "1666.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200179838073860903" "False" "High" "IsMasterProtein" "O76031" "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial OS=Homo sapiens OX=9606 GN=CLPX PE=1 SV=2" "0.000" "False" "39.639" "15" "10" "27" "10" "633" "69.2" "7.58" "73.48" "10" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf07724, Pf10431" "10845" "ENSG00000166855" "CLPX" "A1L428; A8K8F1; B9EGI8; hsa:10845; O76031; Q9H4D9" "" "Mitochondrial protein degradation" "1" "0" "1.006" "0.939" "0.955" "0.998" "1.044" "0.950" "1.005" "0.980" "0.961" "728.9" "733.0" "684.7" "696.2" "727.4" "761.0" "692.8" "732.4" "714.6" "700.6" "" "" "" "" "" "" "" "" "" "" "436.2" "380.9" "379.2" "326.8" "337.2" "389.5" "322.1" "328.8" "387.7" "700.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6625337675714682058" "False" "High" "IsMasterProtein" "P33176" "Kinesin-1 heavy chain OS=Homo sapiens OX=9606 GN=KIF5B PE=1 SV=1" "0.000" "False" "39.632" "11" "10" "17" "9" "963" "109.6" "6.51" "46.97" "10" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3799" "ENSG00000170759" "KIF5B" "A0AVB2; hsa:3799; P33176; Q5VZ85" "Alzheimer's disease and miRNA effects; Envelope proteins and their potential roles in EDMD physiopathology; Insulin signaling; CCL18 signaling pathway; Alzheimer's disease" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Signaling by ALK fusions and activated point mutants; Insulin processing; RHO GTPases activate KTN1" "11" "1" "1.108" "1.070" "1.206" "1.312" "1.249" "1.196" "0.866" "1.114" "3.621" "367.2" "407.0" "392.8" "442.7" "481.9" "458.7" "439.2" "318.2" "409.1" "1329.8" "" "" "" "" "" "" "" "" "" "" "219.8" "211.5" "217.5" "207.9" "223.4" "234.8" "204.2" "142.8" "222.0" "1329.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5955155913055998566" "False" "High" "IsMasterProtein" "P28062" "Proteasome subunit beta type-8 OS=Homo sapiens OX=9606 GN=PSMB8 PE=1 SV=3" "0.000" "False" "39.561" "33" "9" "25" "9" "276" "30.3" "7.43" "61.59" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227" "5696" "ENSG00000204264; ENSG00000206298; ENSG00000226201; ENSG00000230034; ENSG00000230669; ENSG00000231631; ENSG00000235715; ENSG00000236443" "PSMB8" "B0UZC0; hsa:5696; P28062; Q29824; Q5JNW6; Q5QNR8; Q96J48" "Proteasome degradation; Immune response to tuberculosis" "Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Interferon alpha/beta signaling" "62" "0" "0.986" "0.990" "1.012" "1.054" "0.973" "0.994" "1.081" "1.054" "0.604" "1042.2" "1027.3" "1031.7" "1054.9" "1098.0" "1013.8" "1035.5" "1127.0" "1098.1" "629.0" "" "" "" "" "" "" "" "" "" "" "623.7" "533.8" "571.3" "495.2" "508.9" "519.0" "481.5" "506.0" "595.8" "629.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3418505594273786343" "False" "High" "IsMasterProtein" "P48735" "Isocitrate dehydrogenase [NADP], mitochondrial OS=Homo sapiens OX=9606 GN=IDH2 PE=1 SV=2" "0.000" "False" "39.514" "26" "10" "20" "9" "452" "50.9" "8.69" "57.96" "10" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00180" "3418" "ENSG00000182054" "IDH2" "B2R6L6; B4DFL2; hsa:3418; P48735; Q96GT3" "VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer; Cerebral organic acidurias, including diseases; TCA cycle (aka Krebs or citric acid cycle)" "Mitochondrial protein degradation; Transcriptional activation of mitochondrial biogenesis; Citric acid cycle (TCA cycle)" "7" "0" "1.001" "0.926" "0.970" "1.036" "1.019" "1.069" "0.910" "0.974" "1.063" "479.8" "480.0" "444.2" "465.2" "497.2" "488.9" "512.7" "436.5" "467.5" "509.9" "" "" "" "" "" "" "" "" "" "" "287.1" "249.5" "246.0" "218.4" "230.4" "250.3" "238.4" "196.0" "253.6" "509.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8845776874603627941" "False" "High" "IsMasterProtein" "Q92930" "Ras-related protein Rab-8B OS=Homo sapiens OX=9606 GN=RAB8B PE=1 SV=2" "0.000" "False" "39.494" "34" "7" "43" "3" "207" "23.6" "9.07" "114.78" "7" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00071" "51762" "ENSG00000166128" "RAB8B" "hsa:51762; Q5JPC4; Q92930; Q9P293" "Ectoderm differentiation; Ectoderm differentiation" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; TBC/RABGAPs" "5" "2" "1.010" "1.027" "1.057" "0.930" "1.039" "0.936" "1.110" "1.063" "0.687" "1293.2" "1305.8" "1328.2" "1367.1" "1202.4" "1343.1" "1210.1" "1436.0" "1375.3" "887.8" "" "" "" "" "" "" "" "" "" "" "773.9" "678.6" "735.5" "641.8" "557.3" "687.6" "562.7" "644.7" "746.2" "887.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8133999276561542569" "False" "High" "IsMasterProtein" "Q86X55" "Histone-arginine methyltransferase CARM1 OS=Homo sapiens OX=9606 GN=CARM1 PE=1 SV=3" "0.000" "False" "39.410" "15" "9" "31" "9" "608" "65.8" "6.73" "87.28" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06325, Pf11531" "10498" "ENSG00000142453" "CARM1" "A6NN38; hsa:10498; Q86X55" "Androgen receptor signaling pathway; Nitric oxide metabolism in cystic fibrosis" "Estrogen-dependent gene expression; Heme signaling; Transcriptional activation of mitochondrial biogenesis; RMTs methylate histone arginines; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; RORA activates gene expression" "15" "0" "0.971" "0.911" "0.997" "1.012" "1.042" "0.954" "1.057" "0.986" "0.744" "2075.6" "2015.6" "1891.2" "2069.8" "2100.8" "2161.8" "1979.9" "2193.2" "2045.8" "1545.2" "" "" "" "" "" "" "" "" "" "" "1242.1" "1047.4" "1047.3" "971.7" "973.8" "1106.7" "920.6" "984.6" "1109.9" "1545.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7172207260123364247" "False" "High" "IsMasterProtein" "P11172" "Uridine 5'-monophosphate synthase OS=Homo sapiens OX=9606 GN=UMPS PE=1 SV=1" "0.000" "False" "39.340" "23" "11" "23" "11" "480" "52.2" "7.24" "61.92" "11" "other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00156, Pf00215" "7372" "ENSG00000114491" "UMPS" "B5LY68; B5LY72; hsa:7372; O00758; O00759; O00760; P11172; Q16862; Q9H3Q2; Q9UG49" "Fluoropyrimidine activity; Pyrimidine metabolism" "Pyrimidine biosynthesis" "3" "0" "0.978" "0.912" "0.924" "0.960" "0.996" "0.877" "0.960" "0.958" "0.706" "1902.7" "1860.9" "1735.6" "1759.0" "1825.8" "1894.7" "1669.0" "1827.2" "1822.0" "1343.3" "" "" "" "" "" "" "" "" "" "" "1138.7" "967.0" "961.1" "825.8" "846.3" "970.0" "776.1" "820.3" "988.5" "1343.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3625950205882740020" "False" "High" "IsMasterProtein" "Q9NWQ8" "Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 OS=Homo sapiens OX=9606 GN=PAG1 PE=1 SV=2" "0.000" "False" "39.327" "28" "9" "11" "9" "432" "47.0" "4.65" "32.05" "9" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf15347" "55824" "ENSG00000076641" "PAG1" "A8K1A3; hsa:55824; Q2M1Z9; Q5BKU4; Q9NWQ8; Q9NYK0" "" "Phosphorylation of CD3 and TCR zeta chains; GAB1 signalosome" "2" "0" "1.004" "0.928" "0.873" "0.962" "1.008" "0.939" "1.014" "0.887" "0.416" "709.8" "712.4" "658.5" "620.0" "682.6" "715.6" "666.3" "719.9" "629.3" "295.2" "" "" "" "" "" "" "" "" "" "" "424.8" "370.2" "364.6" "291.1" "316.4" "366.3" "309.8" "323.2" "341.4" "295.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6088825967158896660" "False" "High" "IsMasterProtein" "O43290" "U4/U6.U5 tri-snRNP-associated protein 1 OS=Homo sapiens OX=9606 GN=SART1 PE=1 SV=1" "0.000" "False" "39.247" "14" "9" "13" "9" "800" "90.2" "6.13" "34.08" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf03343, Pf19252" "9092" "ENSG00000175467" "SART1" "A6NDN1; hsa:9092; O43290; Q53GB5" "" "mRNA Splicing - Major Pathway" "1" "0" "1.026" "0.955" "0.944" "0.995" "1.009" "1.014" "1.050" "0.973" "0.467" "366.2" "375.7" "349.6" "345.7" "364.3" "369.5" "371.1" "384.5" "356.2" "171.0" "" "" "" "" "" "" "" "" "" "" "219.1" "195.2" "193.6" "162.3" "168.9" "189.2" "172.6" "172.6" "193.3" "171.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2449426517635308859" "False" "High" "IsMasterProtein" "Q9H6F5" "Coiled-coil domain-containing protein 86 OS=Homo sapiens OX=9606 GN=CCDC86 PE=1 SV=1" "0.000" "False" "39.241" "24" "8" "11" "8" "360" "40.2" "10.33" "35.69" "8" "" "nucleus;other cell component" "" "Pf03879" "79080" "ENSG00000110104" "CCDC86" "B4DY99; hsa:79080; Q9H6F5" "" "" "0" "0" "0.892" "0.929" "0.876" "0.992" "1.003" "1.044" "1.083" "0.969" "0.513" "676.4" "603.1" "628.1" "592.6" "671.3" "678.3" "706.0" "732.6" "655.2" "346.8" "" "" "" "" "" "" "" "" "" "" "404.8" "313.4" "347.8" "278.2" "311.2" "347.2" "328.3" "328.9" "355.5" "346.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5868182849043771837" "False" "High" "IsMasterProtein" "Q15084" "Protein disulfide-isomerase A6 OS=Homo sapiens OX=9606 GN=PDIA6 PE=1 SV=1" "0.000" "False" "39.165" "24" "9" "19" "9" "440" "48.1" "5.08" "46.43" "9" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00085" "10130" "ENSG00000143870" "PDIA6" "B3KY95; B5MCQ5; B7Z254; B7Z4M8; F8WA83; hsa:10130; Q15084; Q53RC7; Q6ZSH5; Q99778" "Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes" "5" "0" "1.017" "0.989" "0.942" "0.998" "1.000" "0.877" "1.011" "1.024" "0.604" "947.5" "963.2" "937.2" "892.3" "945.9" "947.8" "830.6" "957.8" "970.0" "572.0" "" "" "" "" "" "" "" "" "" "" "567.0" "500.6" "519.0" "418.9" "438.4" "485.2" "386.2" "430.0" "526.2" "572.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8447148284608472051" "False" "High" "IsMasterProtein" "Q9H444" "Charged multivesicular body protein 4b OS=Homo sapiens OX=9606 GN=CHMP4B PE=1 SV=1" "0.000" "False" "39.113" "38" "8" "28" "8" "224" "24.9" "4.82" "78.01" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "128866" "ENSG00000101421" "CHMP4B" "E1P5N4; hsa:128866; Q53ZD6; Q9H444" "" "Sealing of the nuclear envelope (NE) by ESCRT-III; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "9" "0" "0.938" "0.849" "0.931" "1.067" "0.994" "1.141" "1.120" "1.038" "0.557" "2239.5" "2101.1" "1901.9" "2086.0" "2390.4" "2226.6" "2555.8" "2507.4" "2325.1" "1247.3" "" "" "" "" "" "" "" "" "" "" "1340.2" "1091.9" "1053.2" "979.3" "1108.0" "1139.9" "1188.4" "1125.7" "1261.4" "1247.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9199223731198630068" "False" "High" "IsMasterProtein" "Q9UIJ7" "GTP:AMP phosphotransferase AK3, mitochondrial OS=Homo sapiens OX=9606 GN=AK3 PE=1 SV=4" "0.000" "False" "39.067" "43" "10" "22" "10" "227" "25.6" "9.16" "60.80" "10" "other metabolic processes;stress response" "mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "50808" "ENSG00000147853" "AK3" "B4DP58; D3DRI1; E7ET30; hsa:50808; Q5VYW6; Q9H576; Q9HC01; Q9NPB4; Q9UIJ7" "" "Factors involved in megakaryocyte development and platelet production" "1" "0" "1.072" "0.978" "0.966" "1.056" "1.068" "1.019" "1.115" "0.993" "0.584" "1200.7" "1286.7" "1174.9" "1160.4" "1268.1" "1281.8" "1223.4" "1338.9" "1192.1" "701.2" "" "" "" "" "" "" "" "" "" "" "718.6" "668.6" "650.6" "544.8" "587.8" "656.2" "568.8" "601.1" "646.8" "701.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5794386193398091018" "False" "High" "IsMasterProtein" "Q9NY33" "Dipeptidyl peptidase 3 OS=Homo sapiens OX=9606 GN=DPP3 PE=1 SV=2" "0.000" "False" "39.061" "12" "8" "13" "8" "737" "82.5" "5.10" "42.15" "8" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf03571" "10072" "ENSG00000254986" "DPP3" "B2RDB5; B4DLX4; F5H8L6; hsa:10072; O95748; Q969H2; Q9BV67; Q9HAL6; Q9NY33" "" "Neddylation; KEAP1-NFE2L2 pathway" "2" "0" "1.084" "1.008" "1.157" "1.116" "1.091" "1.069" "0.938" "1.045" "2.698" "424.6" "460.2" "428.1" "491.4" "473.8" "463.1" "453.8" "398.1" "443.6" "1145.7" "" "" "" "" "" "" "" "" "" "" "254.1" "239.2" "237.1" "230.7" "219.6" "237.1" "211.0" "178.7" "240.7" "1145.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-508494988063673287" "False" "High" "IsMasterProtein" "Q9NXG2" "THUMP domain-containing protein 1 OS=Homo sapiens OX=9606 GN=THUMPD1 PE=1 SV=2" "0.000" "False" "38.974" "32" "10" "23" "10" "353" "39.3" "7.88" "63.21" "10" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02926" "55623" "ENSG00000066654" "THUMPD1" "hsa:55623; Q9BWC3; Q9NXG2" "" "rRNA modification in the nucleus and cytosol" "1" "0" "1.055" "1.066" "1.031" "0.995" "1.029" "0.884" "1.055" "0.995" "0.619" "1614.8" "1703.4" "1720.8" "1665.1" "1606.7" "1662.3" "1426.7" "1704.3" "1606.3" "1000.0" "" "" "" "" "" "" "" "" "" "" "966.3" "885.2" "953.0" "781.7" "744.7" "851.0" "663.4" "765.1" "871.5" "1000.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602347345364685954" "False" "High" "IsMasterProtein" "P09429" "High mobility group protein B1 OS=Homo sapiens OX=9606 GN=HMGB1 PE=1 SV=3" "0.000" "False" "38.917" "28" "8" "41" "6" "215" "24.9" "5.74" "125.48" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "3146" "ENSG00000189403" "HMGB1" "A5D8W9; hsa:3146; P09429; Q14321; Q5T7C3; Q6IBE1" "Retinoblastoma gene in cancer; VEGFA-VEGFR2 signaling; Suppression of HMGB1-mediated inflammation by THBD; Base excision repair; DNA repair pathways, full network; Pleural mesothelioma; Clock-controlled autophagy in bone metabolism; Autophagy in pancreatic ductal adenocarcinoma; DNA damage response (only ATM dependent)" "ER-Phagosome pathway; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation; Neutrophil degranulation; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Apoptosis induced DNA fragmentation; Pyroptosis; Advanced glycosylation endproduct receptor signaling" "20" "1" "0.988" "0.947" "0.954" "1.088" "1.042" "1.024" "1.065" "0.892" "0.599" "2757.6" "2725.0" "2610.8" "2630.7" "2999.2" "2873.8" "2822.9" "2938.2" "2460.5" "1651.7" "" "" "" "" "" "" "" "" "" "" "1650.3" "1416.1" "1445.8" "1235.1" "1390.2" "1471.2" "1312.6" "1319.1" "1334.9" "1651.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6898362588139573585" "False" "High" "IsMasterProtein" "Q01105" "Protein SET OS=Homo sapiens OX=9606 GN=SET PE=1 SV=3" "0.000" "False" "38.908" "20" "5" "24" "5" "290" "33.5" "4.32" "81.63" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00956" "6418" "ENSG00000119335" "SET" "A5A5H4; A6NGV1; B4DUE2; hsa:6418; Q01105; Q15541; Q5VXV1; Q5VXV2; Q6FHZ5" "Histone modifications; VEGFA-VEGFR2 signaling" "HuR (ELAVL1) binds and stabilizes mRNA; Condensation of Prophase Chromosomes" "4" "0" "0.949" "0.999" "0.974" "0.972" "0.889" "0.984" "0.987" "0.940" "1.065" "1038.3" "985.3" "1037.4" "1011.4" "1009.1" "923.5" "1021.3" "1025.0" "975.8" "1106.0" "" "" "" "" "" "" "" "" "" "" "621.4" "512.0" "574.5" "474.8" "467.7" "472.7" "474.9" "460.2" "529.4" "1106.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6821815504623325969" "False" "High" "IsMasterProtein" "Q9UMX0" "Ubiquilin-1 OS=Homo sapiens OX=9606 GN=UBQLN1 PE=1 SV=2" "0.000" "False" "38.879" "21" "8" "17" "3" "589" "62.5" "5.11" "42.24" "8" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "29979" "ENSG00000135018" "UBQLN1" "A0A024R284; hsa:29979; Q5T6J5; Q5T6J9; Q8IXS9; Q8N2Q3; Q9H0T8; Q9H3R4; Q9HAZ5; Q9UMX0" "" "Cargo recognition for clathrin-mediated endocytosis" "1" "4" "1.024" "1.020" "1.082" "1.104" "1.080" "1.121" "1.117" "1.146" "0.725" "491.5" "503.2" "501.2" "531.8" "542.7" "530.6" "551.2" "549.2" "563.2" "356.6" "" "" "" "" "" "" "" "" "" "" "294.1" "261.5" "277.6" "249.7" "251.5" "271.6" "256.3" "246.6" "305.5" "356.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3104846382151978420" "False" "High" "IsMasterProtein" "Q9UKY7" "Protein CDV3 homolog OS=Homo sapiens OX=9606 GN=CDV3 PE=1 SV=1" "0.000" "False" "38.846" "26" "7" "43" "7" "258" "27.3" "6.40" "108.35" "7" "" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf15359" "55573" "ENSG00000091527" "CDV3" "B3KUC2; hsa:55573; Q96IP9; Q9UKY7" "" "" "0" "0" "0.972" "0.971" "0.933" "1.003" "1.029" "0.999" "1.067" "0.948" "0.466" "4027.6" "3915.0" "3912.5" "3757.8" "4041.6" "4144.0" "4023.1" "4297.6" "3817.2" "1875.6" "" "" "" "" "" "" "" "" "" "" "2410.3" "2034.5" "2166.7" "1764.2" "1873.3" "2121.4" "1870.7" "1929.4" "2071.0" "1875.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5165886701298417594" "False" "High" "IsMasterProtein" "Q15459" "Splicing factor 3A subunit 1 OS=Homo sapiens OX=9606 GN=SF3A1 PE=1 SV=1" "0.000" "False" "38.670" "14" "10" "21" "10" "793" "88.8" "5.22" "47.38" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00240, Pf01805, Pf12230" "10291" "ENSG00000099995" "SF3A1" "E9PAW1; hsa:10291; Q15459" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.000" "1.062" "1.126" "1.066" "1.033" "1.132" "0.906" "1.055" "3.423" "559.0" "559.0" "593.5" "629.5" "595.7" "577.6" "632.9" "506.6" "590.0" "1913.6" "" "" "" "" "" "" "" "" "" "" "334.5" "290.5" "328.7" "295.5" "276.1" "295.7" "294.3" "227.4" "320.1" "1913.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3583580330514197896" "False" "High" "IsMasterProtein" "P55809" "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=OXCT1 PE=1 SV=1" "0.000" "False" "38.639" "24" "11" "19" "11" "520" "56.1" "7.46" "57.67" "11" "other metabolic processes" "mitochondrion" "other molecular function" "Pf01144" "5019" "ENSG00000083720" "OXCT1" "B2R5V2; B7Z528; hsa:5019; P55809" "" "Mitochondrial protein degradation; Utilization of Ketone Bodies" "2" "0" "0.952" "0.925" "0.986" "0.981" "0.983" "0.971" "0.946" "0.957" "0.961" "1869.6" "1780.0" "1730.4" "1843.6" "1834.9" "1838.6" "1815.5" "1769.3" "1789.7" "1797.0" "" "" "" "" "" "" "" "" "" "" "1118.9" "925.0" "958.2" "865.5" "850.5" "941.2" "844.2" "794.3" "971.0" "1797.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9134021061211319467" "False" "High" "IsMasterProtein" "Q9HA77" "Probable cysteine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=CARS2 PE=1 SV=1" "0.000" "False" "38.533" "14" "8" "14" "8" "564" "62.2" "8.34" "44.02" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01406" "79587" "ENSG00000134905" "CARS2" "hsa:79587; Q8NI84; Q96IV4; Q9HA77" "" "Mitochondrial tRNA aminoacylation" "1" "0" "1.069" "1.024" "0.990" "1.011" "1.085" "1.046" "1.087" "1.033" "0.729" "816.1" "872.1" "836.0" "808.2" "824.9" "885.4" "853.4" "886.9" "843.4" "594.6" "" "" "" "" "" "" "" "" "" "" "488.4" "453.2" "462.9" "379.4" "382.4" "453.2" "396.8" "398.1" "457.6" "594.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3364177795992672609" "False" "High" "IsMasterProtein" "P42765" "3-ketoacyl-CoA thiolase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAA2 PE=1 SV=2" "0.000" "False" "38.533" "29" "10" "35" "10" "397" "41.9" "8.09" "87.37" "10" "cell organization and biogenesis;other metabolic processes;stress response;transport" "mitochondrion" "other molecular function" "Pf00108, Pf02803" "10449" "ENSG00000167315" "ACAA2" "hsa:10449; P42765; Q9BUT6" "Fatty acid biosynthesis" "Mitochondrial Fatty Acid Beta-Oxidation" "2" "0" "0.997" "0.990" "0.968" "0.942" "0.987" "0.930" "0.974" "0.955" "0.495" "1932.6" "1925.8" "1913.9" "1871.1" "1819.8" "1906.7" "1797.0" "1882.1" "1845.2" "957.1" "" "" "" "" "" "" "" "" "" "" "1156.5" "1000.8" "1059.9" "878.4" "843.5" "976.1" "835.6" "845.0" "1001.1" "957.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7380698507310522757" "False" "High" "IsMasterProtein" "P41227" "N-alpha-acetyltransferase 10 OS=Homo sapiens OX=9606 GN=NAA10 PE=1 SV=1" "0.000" "False" "38.452" "39" "9" "14" "9" "235" "26.4" "5.64" "36.92" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "8260" "ENSG00000102030" "NAA10" "A6NM98; hsa:8260; P41227" "" "" "0" "0" "1.065" "0.985" "0.917" "1.052" "1.002" "0.956" "0.974" "0.929" "0.720" "612.7" "652.8" "603.4" "561.6" "644.6" "613.9" "585.8" "596.8" "569.4" "441.0" "" "" "" "" "" "" "" "" "" "" "366.7" "339.2" "334.1" "263.7" "298.8" "314.3" "272.4" "267.9" "308.9" "441.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6508547570803101910" "False" "High" "IsMasterProtein" "Q00169" "Phosphatidylinositol transfer protein alpha isoform OS=Homo sapiens OX=9606 GN=PITPNA PE=1 SV=2" "0.000" "False" "38.434" "36" "10" "23" "8" "270" "31.8" "6.55" "64.87" "10" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf02121" "5306" "ENSG00000174238" "PITPNA" "hsa:5306; Q00169" "" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Role of second messengers in netrin-1 signaling" "2" "2" "0.976" "0.969" "0.979" "0.983" "1.062" "0.996" "1.046" "0.994" "0.651" "1336.8" "1304.2" "1295.7" "1308.9" "1314.4" "1419.4" "1331.9" "1398.7" "1328.9" "869.8" "" "" "" "" "" "" "" "" "" "" "800.0" "677.8" "717.5" "614.5" "609.2" "726.6" "619.3" "627.9" "721.0" "869.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-154777414140805672" "False" "High" "IsMasterProtein" "P20810" "Calpastatin OS=Homo sapiens OX=9606 GN=CAST PE=1 SV=4" "0.000" "False" "38.377" "18" "11" "16" "11" "708" "76.5" "5.07" "40.16" "11" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00748" "831" "ENSG00000153113" "CAST" "B7Z468; G5E946; G5E9D3; hsa:831; O95360; P20810; Q05DE8; Q7Z4K0; Q96D08; Q9H1Z5" "" "Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "2" "0" "0.937" "0.906" "0.855" "1.012" "0.907" "0.909" "0.991" "0.908" "0.429" "945.7" "886.0" "857.2" "808.8" "957.3" "857.6" "860.0" "937.4" "858.7" "405.5" "" "" "" "" "" "" "" "" "" "" "566.0" "460.4" "474.7" "379.7" "443.7" "439.1" "399.9" "420.8" "465.9" "405.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1018884242771776576" "False" "High" "IsMasterProtein" "P30048" "Thioredoxin-dependent peroxide reductase, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX3 PE=1 SV=3" "0.000" "False" "38.357" "31" "7" "31" "7" "256" "27.7" "7.78" "81.96" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00578, Pf10417" "10935" "ENSG00000165672" "PRDX3" "B2R7Z0; D3DRC9; E9PH29; hsa:10935; P30048; P35690; Q0D2H1; Q13776; Q5T5V2; Q96HK4" "Selenium micronutrient network" "Detoxification of Reactive Oxygen Species" "2" "0" "1.120" "1.116" "1.046" "1.106" "1.201" "1.041" "1.147" "1.150" "0.748" "882.6" "988.7" "984.6" "923.5" "975.8" "1059.7" "918.6" "1012.2" "1015.2" "660.4" "" "" "" "" "" "" "" "" "" "" "528.2" "513.8" "545.2" "433.6" "452.3" "542.5" "427.1" "454.4" "550.8" "660.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8097806180956091720" "False" "High" "IsMasterProtein" "Q16576" "Histone-binding protein RBBP7 OS=Homo sapiens OX=9606 GN=RBBP7 PE=1 SV=1" "0.000" "False" "38.258" "30" "10" "25" "6" "425" "47.8" "5.05" "69.23" "10" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "5931" "ENSG00000102054" "RBBP7" "hsa:5931; Q16576; Q5JP00" "Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Effect of progerin on genes involved in progeria" "HCMV Early Events; Neddylation; Potential therapeutics for SARS; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RMTs methylate histone arginines; PKMTs methylate histone lysines; HATs acetylate histones; RNA Polymerase I Transcription Initiation; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "20" "4" "1.029" "1.077" "1.056" "1.043" "1.108" "1.030" "1.052" "1.083" "0.934" "1250.8" "1287.5" "1347.4" "1320.9" "1305.1" "1385.9" "1288.3" "1316.0" "1355.2" "1167.8" "" "" "" "" "" "" "" "" "" "" "748.5" "669.1" "746.1" "620.1" "604.9" "709.5" "599.0" "590.8" "735.2" "1167.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2439136335340173205" "False" "High" "IsMasterProtein" "P22681" "E3 ubiquitin-protein ligase CBL OS=Homo sapiens OX=9606 GN=CBL PE=1 SV=2" "0.000" "False" "38.243" "14" "9" "12" "9" "906" "99.6" "6.54" "35.39" "9" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00097, Pf00627, Pf02262, Pf02761, Pf02762" "867" "ENSG00000110395" "CBL" "A3KMP8; P22681" "RANKL/RANK signaling pathway; Prolactin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; IL-4 signaling pathway; MET in type 1 papillary renal cell carcinoma; EGF/EGFR signaling pathway; Insulin signaling; IL-2 signaling pathway; 4p16.3 copy number variation; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "Regulation of signaling by CBL; Regulation of KIT signaling; Negative regulation of FLT3; Cargo recognition for clathrin-mediated endocytosis; Interleukin-6 signaling; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Signaling by CSF1 (M-CSF) in myeloid cells; Spry regulation of FGF signaling; TGF-beta receptor signaling activates SMADs; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; FLT3 signaling by CBL mutants" "39" "0" "1.060" "1.095" "1.181" "1.240" "1.150" "1.100" "1.206" "1.148" "0.938" "256.2" "271.5" "280.5" "302.7" "317.6" "294.6" "282.0" "309.1" "294.2" "240.4" "" "" "" "" "" "" "" "" "" "" "153.3" "141.1" "155.3" "142.1" "147.2" "150.8" "131.1" "138.8" "159.6" "240.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5376062369618088086" "False" "High" "IsMasterProtein" "P01834" "Immunoglobulin kappa constant OS=Homo sapiens OX=9606 GN=IGKC PE=1 SV=2" "0.000" "False" "38.203" "66" "4" "11" "4" "107" "11.8" "6.52" "38.40" "4" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf07654" "" "" "IGKC" "A0A075B6H6; A0A087X130; P01834" "" "Initial triggering of complement; Classical antibody-mediated complement activation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Scavenging of heme from plasma; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "19" "0" "1.055" "1.080" "1.074" "1.048" "1.069" "1.053" "0.980" "1.004" "0.709" "778.9" "822.0" "841.1" "836.7" "816.7" "832.5" "820.0" "763.7" "781.8" "552.5" "" "" "" "" "" "" "" "" "" "" "466.1" "427.2" "465.8" "392.8" "378.6" "426.2" "381.3" "342.8" "424.2" "552.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2447510198658431817" "False" "High" "IsMasterProtein" "Q9H910" "Jupiter microtubule associated homolog 2 OS=Homo sapiens OX=9606 GN=JPT2 PE=1 SV=1" "0.000" "False" "38.119" "43" "7" "18" "7" "190" "20.1" "9.26" "48.95" "7" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf17054" "90861" "ENSG00000206053" "JPT2" "B1AJY2; B4DLH4; hsa:90861; Q6EIC7; Q9H910" "" "" "0" "0" "0.946" "0.992" "1.035" "1.044" "1.062" "1.114" "1.168" "1.005" "0.506" "523.2" "494.7" "518.9" "541.2" "546.1" "555.7" "582.7" "611.3" "525.9" "264.5" "" "" "" "" "" "" "" "" "" "" "313.1" "257.1" "287.4" "254.1" "253.1" "284.5" "271.0" "274.4" "285.3" "264.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7059158695698353069" "False" "High" "IsMasterProtein" "Q9H0U4" "Ras-related protein Rab-1B OS=Homo sapiens OX=9606 GN=RAB1B PE=1 SV=1" "0.000" "False" "38.084" "41" "7" "35" "1" "201" "22.2" "5.73" "87.85" "7" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "81876" "ENSG00000174903" "RAB1B" "A8K7S1; hsa:81876; Q9H0U4" "" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization" "6" "0" "1.046" "0.909" "0.876" "0.994" "0.869" "0.817" "1.143" "0.971" "0.832" "24.8" "26.0" "22.6" "21.8" "24.7" "21.6" "20.3" "28.4" "24.1" "20.7" "" "" "" "" "" "" "" "" "" "" "14.9" "13.5" "12.5" "10.2" "11.4" "11.1" "9.4" "12.7" "13.1" "20.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "325736081283403068" "False" "High" "IsMasterProtein" "P35637" "RNA-binding protein FUS OS=Homo sapiens OX=9606 GN=FUS PE=1 SV=1" "0.000" "False" "37.965" "14" "7" "26" "5" "526" "53.4" "9.36" "72.89" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641" "2521" "ENSG00000089280" "FUS" "hsa:2521; P35637; Q9H4A8" "MECP2 and associated Rett syndrome; mRNA processing; HDAC6 interactions in the central nervous system" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "5" "2" "0.990" "0.966" "0.991" "1.037" "0.985" "1.010" "1.038" "0.958" "0.497" "2892.1" "2862.2" "2792.5" "2864.7" "2997.9" "2848.4" "2920.1" "3001.5" "2770.9" "1438.1" "" "" "" "" "" "" "" "" "" "" "1730.8" "1487.4" "1546.4" "1344.9" "1389.6" "1458.2" "1357.8" "1347.5" "1503.3" "1438.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8647128743561798150" "False" "High" "IsMasterProtein" "P78417" "Glutathione S-transferase omega-1 OS=Homo sapiens OX=9606 GN=GSTO1 PE=1 SV=2" "0.000" "False" "37.898" "36" "9" "19" "9" "241" "27.5" "6.60" "56.78" "9" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13409, Pf14497" "9446" "ENSG00000148834" "GSTO1" "D3DRA3; F5H7H0; hsa:9446; P78417; Q5TA03; Q7Z3T2" "Myometrial relaxation and contraction pathways; Arsenic metabolism and reactive oxygen species generation; Metapathway biotransformation Phase I and II" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Glutathione conjugation; Vitamin C (ascorbate) metabolism; Methylation" "7" "0" "1.052" "1.059" "1.023" "0.932" "0.993" "0.989" "0.975" "0.929" "0.799" "1720.6" "1810.8" "1822.9" "1759.4" "1603.8" "1709.2" "1702.3" "1677.5" "1599.0" "1374.7" "" "" "" "" "" "" "" "" "" "" "1029.7" "941.0" "1009.5" "826.0" "743.4" "875.0" "791.6" "753.1" "867.5" "1374.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2192359693732382121" "False" "High" "IsMasterProtein" "O95433" "Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Homo sapiens OX=9606 GN=AHSA1 PE=1 SV=1" "0.000" "False" "37.891" "30" "10" "19" "10" "338" "38.3" "5.53" "53.74" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi" "other molecular function" "Pf08327, Pf09229" "10598" "ENSG00000100591" "AHSA1" "B2R9L2; B4DUR9; hsa:10598; O95433; Q96IL6; Q9P060" "T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection" "" "1" "0" "1.131" "1.235" "1.113" "1.231" "1.262" "1.105" "0.836" "1.152" "4.597" "731.7" "827.8" "903.9" "814.5" "900.9" "923.3" "808.7" "611.7" "842.8" "3363.5" "" "" "" "" "" "" "" "" "" "" "437.9" "430.2" "500.5" "382.4" "417.6" "472.7" "376.0" "274.6" "457.2" "3363.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2064522308959827201" "False" "High" "IsMasterProtein" "Q92841" "Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens OX=9606 GN=DDX17 PE=1 SV=2" "0.000" "False" "37.882" "15" "9" "21" "5" "729" "80.2" "8.27" "56.66" "9" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "10521" "ENSG00000100201" "DDX17" "B1AHM0; H3BLZ8; hsa:10521; Q69YT1; Q6ICD6; Q92841" "Novel intracellular components of RIG-I-like receptor pathway" "SUMOylation of transcription cofactors" "2" "0" "1.146" "1.073" "0.830" "1.076" "1.140" "0.946" "0.935" "1.095" "3.708" "83.0" "95.1" "89.0" "68.9" "89.3" "94.7" "78.5" "77.6" "90.8" "307.8" "" "" "" "" "" "" "" "" "" "" "49.7" "49.4" "49.3" "32.3" "41.4" "48.5" "36.5" "34.8" "49.3" "307.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6094529598036827804" "False" "High" "IsMasterProtein" "Q13442" "28 kDa heat- and acid-stable phosphoprotein OS=Homo sapiens OX=9606 GN=PDAP1 PE=1 SV=1" "0.000" "False" "37.874" "46" "7" "25" "7" "181" "20.6" "8.87" "69.24" "7" "signal transduction" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "" "Pf10252" "11333" "ENSG00000106244" "PDAP1" "D6W5S5; hsa:11333; Q13442; Q92906" "" "Neutrophil degranulation" "1" "0" "0.837" "0.861" "0.763" "0.885" "0.881" "0.791" "0.837" "0.807" "0.374" "1643.3" "1374.8" "1414.2" "1254.4" "1455.1" "1447.1" "1299.3" "1374.8" "1326.8" "615.1" "" "" "" "" "" "" "" "" "" "" "983.4" "714.5" "783.2" "588.9" "674.4" "740.8" "604.2" "617.2" "719.9" "615.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1761258682097812184" "False" "High" "IsMasterProtein" "Q9NS86" "LanC-like protein 2 OS=Homo sapiens OX=9606 GN=LANCL2 PE=1 SV=1" "0.000" "False" "37.700" "15" "6" "17" "6" "450" "50.8" "7.43" "45.79" "6" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf05147" "55915" "ENSG00000132434" "LANCL2" "B2R8D4; hsa:55915; Q6NSL4; Q8TCQ3; Q9BSR1; Q9NS86" "" "" "0" "0" "1.017" "1.014" "1.009" "0.955" "1.107" "0.948" "0.989" "0.953" "0.640" "746.7" "759.2" "757.2" "753.3" "712.9" "826.2" "708.1" "738.5" "711.6" "478.1" "" "" "" "" "" "" "" "" "" "" "446.9" "394.5" "419.3" "353.6" "330.4" "423.0" "329.2" "331.6" "386.1" "478.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2660523182149503333" "False" "High" "IsMasterProtein" "Q9UKK9" "ADP-sugar pyrophosphatase OS=Homo sapiens OX=9606 GN=NUDT5 PE=1 SV=1" "0.000" "False" "37.647" "25" "6" "20" "6" "219" "24.3" "4.94" "60.77" "6" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00293" "11164" "ENSG00000165609" "NUDT5" "A8K516; hsa:11164; Q6IAG0; Q9UH49; Q9UKK9" "" "Phosphate bond hydrolysis by NUDT proteins" "1" "0" "0.878" "0.847" "0.858" "0.879" "0.830" "0.975" "0.823" "0.890" "0.604" "745.4" "654.3" "631.5" "639.8" "655.1" "618.4" "727.0" "613.2" "663.1" "449.9" "" "" "" "" "" "" "" "" "" "" "446.1" "340.0" "349.7" "300.3" "303.7" "316.6" "338.0" "275.3" "359.8" "449.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7235259727744776076" "False" "High" "IsMasterProtein" "Q7Z4W1" "L-xylulose reductase OS=Homo sapiens OX=9606 GN=DCXR PE=1 SV=2" "0.000" "False" "37.596" "31" "7" "32" "7" "244" "25.9" "8.10" "101.11" "7" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf13561" "51181" "ENSG00000169738" "DCXR" "hsa:51181; Q7Z4W1; Q9BTZ3; Q9UHY9" "" "Formation of xylulose-5-phosphate; Essential pentosuria" "2" "0" "0.977" "0.980" "1.034" "1.111" "1.113" "0.958" "1.097" "1.017" "0.661" "1919.7" "1874.7" "1880.5" "1985.0" "2132.1" "2136.1" "1838.2" "2106.2" "1952.4" "1268.6" "" "" "" "" "" "" "" "" "" "" "1148.8" "974.2" "1041.4" "931.9" "988.3" "1093.5" "854.7" "945.6" "1059.3" "1268.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1314773965349869651" "False" "High" "IsMasterProtein" "Q9BRP8" "Partner of Y14 and mago OS=Homo sapiens OX=9606 GN=PYM1 PE=1 SV=1" "0.000" "False" "37.561" "39" "6" "13" "6" "204" "22.6" "9.45" "38.59" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf09282" "84305" "ENSG00000170473" "PYM1" "B6ZDM5; hsa:84305; Q8IXJ8; Q8N8E7; Q9BRP8" "TAR syndrome" "" "1" "0" "0.960" "0.982" "0.914" "1.007" "0.945" "1.043" "1.123" "0.982" "0.451" "554.8" "532.8" "544.9" "507.0" "558.8" "524.1" "578.4" "623.0" "544.8" "250.4" "" "" "" "" "" "" "" "" "" "" "332.0" "276.9" "301.7" "238.0" "259.0" "268.3" "269.0" "279.7" "295.6" "250.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7740854368523393254" "False" "High" "IsMasterProtein" "Q9NR30" "Nucleolar RNA helicase 2 OS=Homo sapiens OX=9606 GN=DDX21 PE=1 SV=5" "0.000" "False" "37.553" "13" "10" "15" "10" "783" "87.3" "9.28" "35.95" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08152" "9188" "ENSG00000165732" "DDX21" "B2RDL0; hsa:9188; Q13436; Q5VX41; Q68D35; Q9NR30" "10q11.21q11.23 copy number variation syndrome; Rubinstein-Taybi syndrome 1" "B-WICH complex positively regulates rRNA expression; Major pathway of rRNA processing in the nucleolus and cytosol" "4" "0" "1.027" "1.019" "1.026" "1.085" "1.032" "1.110" "0.857" "1.100" "4.918" "312.8" "321.2" "318.7" "321.0" "339.4" "322.7" "347.3" "268.2" "343.9" "1538.5" "" "" "" "" "" "" "" "" "" "" "187.2" "166.9" "176.5" "150.7" "157.3" "165.2" "161.5" "120.4" "186.6" "1538.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6444296704773161539" "False" "High" "IsMasterProtein" "Q9NSD9" "Phenylalanine--tRNA ligase beta subunit OS=Homo sapiens OX=9606 GN=FARSB PE=1 SV=3" "0.000" "False" "37.514" "19" "12" "25" "12" "589" "66.1" "6.84" "54.60" "12" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf03483, Pf03484, Pf17759, Pf18262" "10056" "ENSG00000116120" "FARSB" "B4DFM0; hsa:10056; O95708; Q4ZFX1; Q57ZJ5; Q9NSD9; Q9NZZ6" "VEGFA-VEGFR2 signaling; Amino acid metabolism" "Cytosolic tRNA aminoacylation" "3" "0" "0.995" "0.989" "0.967" "1.068" "1.064" "1.009" "0.735" "1.032" "4.053" "597.2" "594.3" "590.6" "577.3" "637.6" "635.3" "602.6" "438.8" "616.4" "2420.4" "" "" "" "" "" "" "" "" "" "" "357.4" "308.8" "327.0" "271.0" "295.5" "325.2" "280.2" "197.0" "334.4" "2420.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4988285782465549683" "False" "High" "IsMasterProtein" "Q9NYB0" "Telomeric repeat-binding factor 2-interacting protein 1 OS=Homo sapiens OX=9606 GN=TERF2IP PE=1 SV=1" "0.000" "False" "37.509" "22" "8" "10" "8" "399" "44.2" "4.73" "32.79" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08914, Pf11626, Pf16589" "54386" "ENSG00000166848" "TERF2IP" "B4DQN4; hsa:54386; Q4W4Y2; Q8WYZ3; Q9NWR2; Q9NYB0" "Splicing factor NOVA regulated synaptic proteins; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Meiotic synapsis; Telomere Extension By Telomerase; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Removal of the Flap Intermediate from the C-strand" "16" "0" "1.051" "1.106" "1.063" "1.101" "0.944" "0.998" "0.954" "0.990" "1.861" "707.6" "743.5" "782.8" "752.0" "778.9" "668.0" "706.2" "675.3" "700.2" "1316.7" "" "" "" "" "" "" "" "" "" "" "423.5" "386.4" "433.5" "353.0" "361.0" "341.9" "328.4" "303.1" "379.9" "1316.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1377635877244790923" "False" "High" "IsMasterProtein" "P36873" "Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CC PE=1 SV=1" "0.000" "False" "37.499" "32" "9" "23" "3" "323" "37.0" "6.54" "52.88" "9" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5501" "ENSG00000186298" "PPP1CC" "hsa:5501; P36873" "Common pathways underlying drug addiction; Focal adhesion; Hippo-Merlin signaling dysregulation; Neuroinflammation and glutamatergic signaling" "Triglyceride catabolism; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Circadian Clock; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins" "17" "0" "0.917" "0.998" "1.050" "1.059" "0.869" "1.006" "0.983" "1.012" "0.960" "308.0" "282.5" "307.5" "323.3" "326.1" "267.5" "309.8" "302.9" "311.6" "295.8" "" "" "" "" "" "" "" "" "" "" "184.3" "146.8" "170.3" "151.8" "151.1" "137.0" "144.0" "136.0" "169.1" "295.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "52020500018808800" "False" "High" "IsMasterProtein" "Q9H773" "dCTP pyrophosphatase 1 OS=Homo sapiens OX=9606 GN=DCTPP1 PE=1 SV=1" "0.000" "False" "37.480" "45" "9" "26" "9" "170" "18.7" "5.03" "66.58" "9" "DNA metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf12643" "79077" "ENSG00000179958" "DCTPP1" "hsa:79077; Q9H773" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "0.966" "1.002" "1.139" "1.193" "1.085" "1.233" "1.258" "1.108" "0.731" "700.1" "676.0" "701.7" "797.8" "835.1" "759.9" "863.5" "880.9" "775.5" "512.1" "" "" "" "" "" "" "" "" "" "" "419.0" "351.3" "388.6" "374.6" "387.1" "389.0" "401.5" "395.5" "420.7" "512.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6733467377289635687" "False" "High" "IsMasterProtein" "Q13838" "Spliceosome RNA helicase DDX39B OS=Homo sapiens OX=9606 GN=DDX39B PE=1 SV=1" "0.000" "False" "37.473" "27" "12" "33" "4" "428" "49.0" "5.67" "69.78" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "7919" "ENSG00000198563; ENSG00000215425; ENSG00000225073; ENSG00000225859; ENSG00000229496; ENSG00000230624; ENSG00000235439" "DDX39B" "B0S8C0; hsa:7919; O43496; Q0EFA1; Q13838; Q2L6F9; Q53GL9; Q5RJ64; Q5RJ66; Q5ST94; Q5STB4; Q5STB5; Q5STB7; Q5STB8; Q5STU4; Q5STU5; Q5STU6; Q5STU8; Q71V76" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; RHOBTB2 GTPase cycle" "5" "6" "1.025" "1.045" "1.088" "1.060" "1.174" "0.987" "1.058" "1.033" "1.860" "1346.5" "1380.3" "1407.1" "1464.5" "1426.7" "1580.3" "1328.8" "1424.7" "1390.7" "2504.5" "" "" "" "" "" "" "" "" "" "" "805.8" "717.3" "779.2" "687.5" "661.3" "809.0" "617.8" "639.6" "754.5" "2504.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9189590484777075943" "False" "High" "IsMasterProtein" "Q13185" "Chromobox protein homolog 3 OS=Homo sapiens OX=9606 GN=CBX3 PE=1 SV=4" "0.000" "False" "37.451" "32" "6" "12" "5" "183" "20.8" "5.33" "33.52" "6" "cell organization and biogenesis;stress response;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00385, Pf01393" "11335" "ENSG00000122565" "CBX3" "hsa:11335; Q13185; Q96CD7; Q99409; Q9BVS3; Q9P0Z6" "Exercise-induced circadian regulation; Effect of progerin on genes involved in progeria; NIPBL role in DNA damage - Cornelia de Lange syndrome" "RNA Polymerase I Promoter Escape; Transcriptional Regulation by E2F6; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" "6" "0" "1.114" "1.536" "1.115" "1.199" "1.141" "1.159" "0.966" "1.035" "1.975" "278.2" "309.8" "427.3" "310.2" "333.6" "317.5" "322.4" "268.7" "287.9" "549.5" "" "" "" "" "" "" "" "" "" "" "166.5" "161.0" "236.6" "145.6" "154.6" "162.6" "149.9" "120.6" "156.2" "549.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1724337932377857957" "False" "High" "IsMasterProtein" "Q13619" "Cullin-4A OS=Homo sapiens OX=9606 GN=CUL4A PE=1 SV=3" "0.000" "False" "37.406" "12" "11" "14" "4" "759" "87.6" "8.13" "39.18" "11" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8451" "ENSG00000139842" "CUL4A" "A2A2W2; hsa:8451; O75834; Q13619; Q589T6; Q5TC62; Q6UP08; Q9UP17" "Hippo-Merlin signaling dysregulation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER; Dual Incision in GG-NER" "13" "0" "0.978" "1.107" "1.086" "1.066" "1.146" "1.037" "0.781" "1.155" "5.227" "87.9" "85.9" "97.4" "95.5" "93.7" "100.7" "91.1" "68.6" "101.6" "459.6" "" "" "" "" "" "" "" "" "" "" "52.6" "44.7" "53.9" "44.8" "43.5" "51.6" "42.4" "30.8" "55.1" "459.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4406338825216404645" "False" "High" "IsMasterProtein" "Q16740" "ATP-dependent Clp protease proteolytic subunit, mitochondrial OS=Homo sapiens OX=9606 GN=CLPP PE=1 SV=1" "0.000" "False" "37.239" "30" "7" "24" "7" "277" "30.2" "8.09" "67.94" "7" "protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00574" "8192" "ENSG00000125656" "CLPP" "B2R4W5; hsa:8192; Q16740" "Primary ovarian insufficiency" "Mitochondrial protein degradation" "2" "0" "0.955" "0.906" "0.781" "0.904" "0.840" "0.779" "0.766" "0.903" "0.532" "1300.9" "1242.9" "1178.5" "1015.5" "1176.2" "1092.5" "1012.8" "996.0" "1174.7" "692.3" "" "" "" "" "" "" "" "" "" "" "778.5" "645.9" "652.6" "476.8" "545.2" "559.3" "470.9" "447.1" "637.3" "692.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3851327045355939363" "False" "High" "IsMasterProtein" "P16401" "Histone H1.5 OS=Homo sapiens OX=9606 GN=H1-5 PE=1 SV=3" "0.000" "False" "37.181" "24" "6" "49" "3" "226" "22.6" "10.92" "130.56" "6" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3009" "ENSG00000184357" "H1-5" "hsa:3009; P16401; Q14529; Q3MJ42" "" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "2" "0" "0.965" "0.999" "0.719" "0.846" "0.883" "0.708" "0.802" "0.809" "0.728" "1369.5" "1322.1" "1368.0" "984.6" "1158.8" "1209.4" "969.4" "1098.3" "1108.2" "996.4" "" "" "" "" "" "" "" "" "" "" "819.5" "687.0" "757.5" "462.3" "537.1" "619.1" "450.8" "493.1" "601.2" "996.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1141032543915842811" "False" "High" "IsMasterProtein" "Q13011" "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial OS=Homo sapiens OX=9606 GN=ECH1 PE=1 SV=2" "0.000" "False" "37.124" "26" "8" "20" "8" "328" "35.8" "8.00" "56.52" "8" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00378" "1891" "ENSG00000104823; ENSG00000282853" "ECH1" "A8K745; hsa:1891; Q13011; Q8WVX0; Q96EZ9" "Fatty acid biosynthesis; IL-18 signaling pathway" "Mitochondrial protein degradation; Peroxisomal protein import" "4" "0" "1.176" "0.971" "1.098" "1.143" "1.081" "1.101" "1.170" "1.067" "1.955" "897.2" "1055.1" "871.0" "984.9" "1025.3" "970.3" "987.6" "1050.1" "957.4" "1753.6" "" "" "" "" "" "" "" "" "" "" "536.9" "548.3" "482.4" "462.4" "475.2" "496.7" "459.2" "471.4" "519.4" "1753.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1318153562653389017" "False" "High" "IsMasterProtein" "O43837" "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3B PE=1 SV=2" "0.000" "False" "37.101" "29" "10" "22" "10" "385" "42.2" "8.46" "56.64" "10" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00180" "3420" "ENSG00000101365" "IDH3B" "B2RDR1; D3DVX2; D3DVX3; hsa:3420; O43837; O95106; Q5JXS8; Q9NQ06; Q9NQ07; Q9NUZ0; Q9UEX0; Q9UG99" "TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle)" "2" "0" "1.010" "1.002" "0.958" "1.015" "0.973" "0.862" "1.010" "0.988" "1.379" "1294.0" "1306.4" "1297.2" "1239.3" "1313.5" "1259.6" "1114.9" "1306.6" "1278.4" "1785.0" "" "" "" "" "" "" "" "" "" "" "774.4" "678.9" "718.3" "581.8" "608.8" "644.8" "518.4" "586.6" "693.6" "1785.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8724268624419382152" "False" "High" "IsMasterProtein" "P50213" "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3A PE=1 SV=1" "0.000" "False" "37.010" "29" "11" "18" "11" "366" "39.6" "6.92" "47.76" "11" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00180" "3419" "ENSG00000166411" "IDH3A" "D3DW83; hsa:3419; P50213; Q9H3X0" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Metabolic reprogramming in colon cancer; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "5" "0" "1.059" "0.994" "0.990" "1.074" "1.108" "1.081" "0.989" "1.025" "1.176" "1179.5" "1249.3" "1172.7" "1167.6" "1267.2" "1307.1" "1275.0" "1166.8" "1209.6" "1386.7" "" "" "" "" "" "" "" "" "" "" "705.9" "649.2" "649.4" "548.2" "587.4" "669.2" "592.9" "523.8" "656.2" "1386.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8993945663539599820" "False" "High" "IsMasterProtein" "P61026" "Ras-related protein Rab-10 OS=Homo sapiens OX=9606 GN=RAB10 PE=1 SV=1" "0.000" "False" "36.788" "42" "8" "38" "6" "200" "22.5" "8.38" "92.78" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "10890" "ENSG00000084733" "RAB10" "D6W538; hsa:10890; O88386; P61026; Q6IA52; Q9D7X6; Q9H0T3" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation; RAB geranylgeranylation" "5" "1" "1.016" "0.958" "1.007" "0.981" "1.044" "1.003" "1.020" "1.024" "0.707" "2481.2" "2521.0" "2378.0" "2498.4" "2433.8" "2591.4" "2487.8" "2531.3" "2540.4" "1754.3" "" "" "" "" "" "" "" "" "" "" "1484.9" "1310.1" "1316.9" "1172.9" "1128.1" "1326.6" "1156.8" "1136.4" "1378.3" "1754.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6826541305752528518" "False" "High" "IsMasterProtein" "P23381" "Tryptophan--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=WARS1 PE=1 SV=2" "0.000" "False" "36.649" "24" "10" "22" "10" "471" "53.1" "6.23" "43.32" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00458, Pf00579" "7453" "ENSG00000140105" "WARS1" "A6NGN1; A6NID3; hsa:7453; P23381; P78535; Q502Y0; Q53XB6; Q9UDI5; Q9UDL3" "Photodynamic therapy-induced unfolded protein response; Amino acid metabolism" "Cytosolic tRNA aminoacylation" "3" "0" "1.043" "1.064" "0.993" "1.027" "1.141" "0.982" "1.047" "1.134" "0.606" "539.8" "563.3" "574.6" "535.8" "554.2" "615.7" "530.0" "565.0" "612.2" "327.0" "" "" "" "" "" "" "" "" "" "" "323.1" "292.7" "318.2" "251.5" "256.9" "315.2" "246.4" "253.6" "332.2" "327.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3011469150095823870" "False" "High" "IsMasterProtein" "Q9Y696" "Chloride intracellular channel protein 4 OS=Homo sapiens OX=9606 GN=CLIC4 PE=1 SV=4" "0.000" "False" "36.477" "28" "6" "14" "6" "253" "28.8" "5.59" "50.96" "6" "transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "transporter activity" "Pf13409" "25932" "ENSG00000169504" "CLIC4" "hsa:25932; Q9UFW9; Q9UQJ6; Q9Y696" "" "" "0" "0" "1.074" "1.036" "0.980" "0.986" "0.962" "0.938" "0.872" "1.023" "1.096" "1327.0" "1424.8" "1374.7" "1299.9" "1307.8" "1276.0" "1244.2" "1157.1" "1357.7" "1454.1" "" "" "" "" "" "" "" "" "" "" "794.2" "740.4" "761.3" "610.3" "606.2" "653.2" "578.5" "519.5" "736.6" "1454.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "350297391460659300" "False" "High" "IsMasterProtein" "Q96CT7" "Coiled-coil domain-containing protein 124 OS=Homo sapiens OX=9606 GN=CCDC124 PE=1 SV=1" "0.000" "False" "36.423" "37" "9" "24" "9" "223" "25.8" "9.54" "61.93" "9" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06244" "115098" "ENSG00000007080" "CCDC124" "hsa:115098; Q96CT7" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.965" "1.021" "0.977" "0.974" "0.991" "0.932" "1.070" "0.922" "0.383" "2380.4" "2297.1" "2430.9" "2324.8" "2319.3" "2359.2" "2219.0" "2547.2" "2193.9" "911.4" "" "" "" "" "" "" "" "" "" "" "1424.5" "1193.7" "1346.2" "1091.5" "1075.0" "1207.8" "1031.8" "1143.5" "1190.3" "911.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2106198041571123129" "False" "High" "IsMasterProtein" "Q9UMS4" "Pre-mRNA-processing factor 19 OS=Homo sapiens OX=9606 GN=PRPF19 PE=1 SV=1" "0.000" "False" "36.372" "20" "9" "34" "9" "504" "55.1" "6.61" "77.43" "9" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400, Pf04564, Pf08606" "27339" "ENSG00000110107" "PRPF19" "Q9UMS4" "" "Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex" "5" "0" "1.011" "1.001" "1.058" "0.936" "1.002" "0.937" "1.006" "0.936" "0.599" "2634.9" "2664.5" "2636.8" "2786.9" "2465.1" "2639.9" "2469.9" "2651.1" "2465.1" "1578.8" "" "" "" "" "" "" "" "" "" "" "1576.9" "1384.7" "1460.2" "1308.4" "1142.6" "1351.4" "1148.5" "1190.2" "1337.4" "1578.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4839945324263831738" "False" "High" "IsMasterProtein" "Q9NTX5" "Ethylmalonyl-CoA decarboxylase OS=Homo sapiens OX=9606 GN=ECHDC1 PE=1 SV=2" "0.000" "False" "36.296" "17" "5" "18" "5" "307" "33.7" "8.21" "50.88" "5" "other metabolic processes" "cytosol" "other molecular function" "Pf00378" "55862" "ENSG00000093144" "ECHDC1" "A6NFJ5; B7Z8S0; E9PEN7; E9PR31; F8W851; hsa:55862; Q5TEF6; Q5TEF7; Q5TEG0; Q5TEG4; Q9NTX5; Q9NZ30; V9HW18" "Fatty acid biosynthesis" "" "1" "0" "1.048" "0.912" "0.986" "1.069" "1.035" "1.077" "1.038" "1.010" "0.675" "1382.0" "1448.9" "1259.8" "1362.2" "1477.3" "1431.0" "1488.4" "1434.7" "1396.4" "932.8" "" "" "" "" "" "" "" "" "" "" "827.1" "753.0" "697.6" "639.5" "684.8" "732.5" "692.1" "644.1" "757.6" "932.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9192930488046834202" "False" "High" "IsMasterProtein" "P25789" "Proteasome subunit alpha type-4 OS=Homo sapiens OX=9606 GN=PSMA4 PE=1 SV=1" "0.000" "False" "36.273" "34" "8" "33" "8" "261" "29.5" "7.72" "85.59" "8" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5685" "ENSG00000041357" "PSMA4" "D3DW86; hsa:5685; P25789; Q53XP2; Q567Q5; Q8TBD1" "Proteasome degradation; Alzheimer's disease and miRNA effects; Exercise-induced circadian regulation; Alzheimer's disease" "Downstream TCR signaling; MAPK6/MAPK4 signaling; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "1.038" "1.042" "1.125" "1.011" "1.059" "1.138" "1.200" "1.117" "0.836" "1289.4" "1337.9" "1343.6" "1451.0" "1303.1" "1365.6" "1467.9" "1546.8" "1440.4" "1077.8" "" "" "" "" "" "" "" "" "" "" "771.6" "695.3" "744.0" "681.2" "604.0" "699.1" "682.5" "694.4" "781.5" "1077.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7186431258293956911" "False" "High" "IsMasterProtein" "Q04837" "Single-stranded DNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SSBP1 PE=1 SV=1" "0.000" "False" "36.216" "58" "8" "20" "8" "148" "17.2" "9.60" "54.54" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00436" "6742" "ENSG00000106028; ENSG00000262771" "SSBP1" "hsa:6742; Q04837" "" "Mitochondrial protein degradation; Transcriptional activation of mitochondrial biogenesis" "2" "0" "0.920" "0.970" "0.865" "0.937" "0.933" "0.853" "0.972" "0.930" "0.477" "2000.7" "1840.1" "1939.8" "1730.3" "1873.7" "1866.3" "1707.5" "1944.2" "1861.1" "954.3" "" "" "" "" "" "" "" "" "" "" "1197.3" "956.2" "1074.2" "812.3" "868.5" "955.4" "793.9" "872.8" "1009.7" "954.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2805084755290845876" "False" "High" "IsMasterProtein" "Q09161" "Nuclear cap-binding protein subunit 1 OS=Homo sapiens OX=9606 GN=NCBP1 PE=1 SV=1" "0.000" "False" "36.141" "16" "10" "17" "10" "790" "91.8" "6.43" "40.62" "10" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02854, Pf09088, Pf09090" "4686" "ENSG00000136937" "NCBP1" "B2R718; hsa:4686; Q09161; Q59G76; Q5T1V0; Q5T7X2" "mRNA processing; 3q29 copy number variation syndrome" "mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RNA polymerase II transcribes snRNA genes; Processing of Intronless Pre-mRNAs; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; snRNP Assembly; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Polymerase II Pre-transcription Events; mRNA Capping; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "29" "0" "1.118" "0.991" "1.081" "1.002" "1.213" "0.951" "1.001" "0.975" "2.018" "552.3" "617.3" "547.5" "597.2" "553.3" "670.1" "525.0" "552.6" "538.6" "1114.7" "" "" "" "" "" "" "" "" "" "" "330.5" "320.8" "303.2" "280.4" "256.5" "343.1" "244.1" "248.1" "292.2" "1114.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8551730055028160476" "False" "High" "IsMasterProtein" "P08579" "U2 small nuclear ribonucleoprotein B'' OS=Homo sapiens OX=9606 GN=SNRPB2 PE=1 SV=1" "0.000" "False" "36.091" "31" "7" "32" "5" "225" "25.5" "9.72" "87.91" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6629" "ENSG00000125870" "SNRPB2" "B2R7J3; D3DW21; hsa:6629; P08579; Q9UJD4" "mRNA processing; Ciliary landscape" "mRNA Splicing - Major Pathway" "3" "2" "1.035" "0.978" "0.968" "0.968" "0.978" "1.022" "1.039" "1.015" "0.708" "1564.2" "1618.4" "1530.0" "1513.9" "1514.1" "1530.1" "1598.4" "1625.1" "1587.0" "1107.8" "" "" "" "" "" "" "" "" "" "" "936.1" "841.0" "847.3" "710.7" "701.8" "783.3" "743.2" "729.6" "861.0" "1107.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4415570283207223737" "False" "High" "IsMasterProtein" "Q08257" "Quinone oxidoreductase OS=Homo sapiens OX=9606 GN=CRYZ PE=1 SV=1" "0.000" "False" "36.067" "29" "9" "14" "9" "329" "35.2" "8.44" "42.00" "9" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf08240, Pf13602" "1429" "ENSG00000116791" "CRYZ" "A6NN60; D3DQ76; hsa:1429; Q08257; Q53FT0; Q59EU7; Q5HYE7; Q6NSK9" "" "" "0" "0" "1.003" "0.923" "0.983" "0.905" "1.014" "0.876" "1.004" "0.960" "0.611" "1684.3" "1689.6" "1554.2" "1656.4" "1524.1" "1708.5" "1474.9" "1690.7" "1617.3" "1028.6" "" "" "" "" "" "" "" "" "" "" "1007.9" "878.0" "860.7" "777.7" "706.5" "874.6" "685.8" "759.0" "877.4" "1028.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4598318327767700223" "False" "High" "IsMasterProtein" "Q96SI9" "Spermatid perinuclear RNA-binding protein OS=Homo sapiens OX=9606 GN=STRBP PE=1 SV=1" "0.000" "False" "36.063" "15" "11" "30" "6" "672" "73.6" "8.72" "78.90" "11" "other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity" "Pf00035, Pf07528, Pf20965" "55342" "ENSG00000165209" "STRBP" "hsa:55342; Q32NB9; Q96SI9; Q9BUE1; Q9BXG4; Q9H0B4; Q9H7V1; Q9NUK4" "" "" "0" "0" "1.125" "1.218" "1.131" "1.189" "1.390" "1.068" "0.998" "1.157" "3.047" "151.3" "170.3" "184.2" "171.2" "179.9" "210.3" "161.7" "151.0" "175.1" "461.0" "" "" "" "" "" "" "" "" "" "" "90.5" "88.5" "102.0" "80.4" "83.4" "107.6" "75.2" "67.8" "95.0" "461.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-797188196996991140" "False" "High" "IsMasterProtein" "P15170" "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A OS=Homo sapiens OX=9606 GN=GSPT1 PE=1 SV=1" "0.000" "False" "36.052" "15" "9" "18" "9" "499" "55.7" "5.62" "41.92" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "2935" "ENSG00000103342" "GSPT1" "hsa:2935; J3KQG6; P15170; Q96GF2" "" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "4" "0" "1.049" "0.998" "1.009" "0.938" "1.017" "0.944" "0.960" "1.000" "0.846" "1102.3" "1156.0" "1100.1" "1112.3" "1034.3" "1121.4" "1040.2" "1057.9" "1101.8" "932.9" "" "" "" "" "" "" "" "" "" "" "659.7" "600.8" "609.2" "522.2" "479.4" "574.1" "483.7" "475.0" "597.8" "932.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5949671281598126574" "False" "High" "IsMasterProtein" "Q13464" "Rho-associated protein kinase 1 OS=Homo sapiens OX=9606 GN=ROCK1 PE=1 SV=1" "0.000" "False" "35.867" "9" "13" "13" "13" "1354" "158.1" "5.90" "29.34" "13" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08912" "6093" "ENSG00000067900" "ROCK1" "B0YJ91; hsa:6093; Q13464; Q2KHM4; Q59GZ4" "Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Gastrin signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; GDNF signaling; G13 signaling pathway" "Neutrophil degranulation; Apoptotic cleavage of cellular proteins; EPHB-mediated forward signaling; Potential therapeutics for SARS; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; VEGFA-VEGFR2 Pathway; RND3 GTPase cycle; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle" "35" "0" "0.992" "1.031" "1.043" "1.153" "1.034" "1.051" "0.631" "1.040" "5.054" "400.7" "397.7" "413.0" "417.9" "462.2" "414.5" "421.1" "252.9" "416.9" "2025.1" "" "" "" "" "" "" "" "" "" "" "239.8" "206.7" "228.7" "196.2" "214.2" "212.2" "195.8" "113.6" "226.2" "2025.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4369435830510499583" "False" "High" "IsMasterProtein" "Q9GZP4" "PITH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PITHD1 PE=1 SV=1" "0.000" "False" "35.840" "57" "11" "23" "11" "211" "24.2" "5.74" "48.79" "11" "other biological processes" "other cell component" "" "Pf06201" "57095" "ENSG00000057757" "PITHD1" "B2R7J4; hsa:57095; Q5QPN6; Q5QPN7; Q9GZP4; Q9NRI8" "" "" "0" "0" "0.957" "0.961" "0.997" "1.031" "0.919" "1.102" "1.056" "0.968" "0.446" "1259.4" "1204.8" "1209.9" "1255.8" "1297.9" "1157.4" "1388.2" "1329.8" "1218.9" "562.0" "" "" "" "" "" "" "" "" "" "" "753.7" "626.1" "670.0" "589.6" "601.6" "592.5" "645.5" "597.0" "661.3" "562.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7164252361216930989" "False" "High" "IsMasterProtein" "P27707" "Deoxycytidine kinase OS=Homo sapiens OX=9606 GN=DCK PE=1 SV=1" "0.000" "False" "35.804" "22" "6" "21" "6" "260" "30.5" "5.21" "64.07" "6" "other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf01712" "1633" "ENSG00000156136" "DCK" "B2R8V6; hsa:1633; P27707; Q5TZY7; Q6FI11" "Retinoblastoma gene in cancer; Pyrimidine metabolism" "Pyrimidine salvage; Purine salvage" "4" "0" "1.005" "0.928" "1.099" "0.969" "1.103" "0.993" "1.029" "0.946" "0.847" "1130.4" "1136.0" "1049.4" "1242.2" "1095.9" "1247.0" "1122.1" "1162.7" "1069.4" "957.8" "" "" "" "" "" "" "" "" "" "" "676.5" "590.3" "581.1" "583.2" "508.0" "638.4" "521.7" "522.0" "580.2" "957.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7222850354556005820" "False" "High" "IsMasterProtein" "P20839" "Inosine-5'-monophosphate dehydrogenase 1 OS=Homo sapiens OX=9606 GN=IMPDH1 PE=1 SV=2" "0.000" "False" "35.772" "18" "8" "24" "6" "514" "55.4" "6.90" "68.02" "8" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00478, Pf00571" "3614" "ENSG00000106348" "IMPDH1" "A4D0Z6; A4D0Z7; A6NDW5; A6NNI6; B3KNP7; B3KVM8; B4DE09; C9JV30; hsa:3614; J3KNX8; P20839; Q8N194; Q96NU2" "" "Potential therapeutics for SARS; Azathioprine ADME; Neutrophil degranulation; Purine ribonucleoside monophosphate biosynthesis" "4" "0" "0.983" "0.931" "1.091" "1.007" "1.028" "1.057" "1.067" "0.936" "0.640" "1418.7" "1395.3" "1320.3" "1548.5" "1428.1" "1457.8" "1499.0" "1513.6" "1327.3" "908.5" "" "" "" "" "" "" "" "" "" "" "849.0" "725.1" "731.1" "727.0" "662.0" "746.3" "697.0" "679.5" "720.1" "908.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6670005547915153643" "False" "High" "IsMasterProtein" "O15400" "Syntaxin-7 OS=Homo sapiens OX=9606 GN=STX7 PE=1 SV=4" "0.000" "False" "35.742" "21" "5" "14" "5" "261" "29.8" "5.55" "48.42" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739, Pf14523" "8417" "ENSG00000079950" "STX7" "E1P579; hsa:8417; O15400; Q5SZW2; Q96ES9" "" "" "0" "0" "1.038" "0.975" "0.978" "1.029" "0.963" "1.043" "0.998" "0.964" "0.481" "1276.7" "1325.5" "1245.2" "1248.2" "1313.5" "1229.5" "1331.0" "1274.3" "1230.4" "614.7" "" "" "" "" "" "" "" "" "" "" "764.1" "688.8" "689.6" "586.0" "608.8" "629.4" "618.9" "572.1" "667.5" "614.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8995832376771225777" "False" "High" "IsMasterProtein" "Q9UBS4" "DnaJ homolog subfamily B member 11 OS=Homo sapiens OX=9606 GN=DNAJB11 PE=1 SV=1" "0.000" "False" "35.631" "20" "7" "11" "7" "358" "40.5" "6.18" "35.99" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00226, Pf01556" "51726" "ENSG00000090520" "DNAJB11" "hsa:51726; Q542Y5; Q542Y9; Q6IAQ8; Q96JC6; Q9UBS4" "Photodynamic therapy-induced unfolded protein response" "XBP1(S) activates chaperone genes" "2" "0" "1.026" "1.005" "1.059" "1.181" "1.045" "1.134" "1.118" "1.179" "1.114" "698.7" "717.2" "702.2" "740.1" "824.9" "730.4" "792.6" "780.8" "823.4" "778.6" "" "" "" "" "" "" "" "" "" "" "418.1" "372.7" "388.8" "347.4" "382.3" "373.9" "368.6" "350.5" "446.7" "778.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1304014562382960910" "False" "High" "IsMasterProtein" "O60216" "Double-strand-break repair protein rad21 homolog OS=Homo sapiens OX=9606 GN=RAD21 PE=1 SV=2" "0.000" "False" "35.498" "16" "10" "16" "10" "631" "71.6" "4.65" "40.94" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04824, Pf04825" "5885" "ENSG00000164754" "RAD21" "A8K0E0; hsa:5885; O60216; Q15001; Q99568" "Cell cycle; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "13" "0" "1.032" "1.004" "1.036" "1.047" "1.030" "1.013" "1.058" "0.992" "1.130" "716.3" "739.0" "719.1" "741.9" "750.3" "737.5" "725.4" "757.8" "710.6" "809.3" "" "" "" "" "" "" "" "" "" "" "428.7" "384.0" "398.2" "348.3" "347.8" "377.5" "337.3" "340.2" "385.5" "809.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8488092828150113306" "False" "High" "IsMasterProtein" "Q86UX7" "Fermitin family homolog 3 OS=Homo sapiens OX=9606 GN=FERMT3 PE=1 SV=1" "0.000" "False" "35.485" "15" "8" "14" "8" "667" "75.9" "6.98" "34.21" "8" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00169, Pf00373, Pf18124" "83706" "ENSG00000149781" "FERMT3" "hsa:83706; Q86UX7; Q8IUA1; Q8N207; Q9BT48" "Leukocyte-intrinsic Hippo pathway functions" "Platelet degranulation" "2" "0" "1.087" "1.073" "1.044" "1.207" "1.260" "1.047" "0.766" "1.136" "4.988" "391.8" "426.0" "420.4" "409.0" "472.9" "493.7" "410.1" "300.1" "445.1" "1954.1" "" "" "" "" "" "" "" "" "" "" "234.5" "221.4" "232.8" "192.0" "219.2" "252.7" "190.7" "134.7" "241.5" "1954.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6441918618070782743" "False" "High" "IsMasterProtein" "P51610" "Host cell factor 1 OS=Homo sapiens OX=9606 GN=HCFC1 PE=1 SV=2" "0.000" "False" "35.473" "6" "12" "23" "12" "2035" "208.6" "7.46" "51.41" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01344, Pf13415, Pf13854" "3054" "ENSG00000172534" "HCFC1" "hsa:3054; P51610; Q6P4G5" "Mitochondrial gene expression; Pleural mesothelioma" "UCH proteinases; Formation of WDR5-containing histone-modifying complexes; Transcriptional activation of mitochondrial biogenesis; HATs acetylate histones" "6" "0" "1.013" "1.037" "1.008" "1.022" "0.977" "0.961" "0.926" "0.972" "1.147" "849.0" "859.6" "880.5" "855.4" "867.8" "829.6" "815.9" "785.7" "825.2" "973.6" "" "" "" "" "" "" "" "" "" "" "508.1" "446.7" "487.6" "401.6" "402.3" "424.7" "379.4" "352.8" "447.7" "973.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "380147253527428052" "False" "High" "IsMasterProtein" "Q9NRR5" "Ubiquilin-4 OS=Homo sapiens OX=9606 GN=UBQLN4 PE=1 SV=2" "0.000" "False" "35.422" "17" "7" "11" "5" "601" "63.8" "5.22" "28.26" "7" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "56893" "ENSG00000160803" "UBQLN4" "A6ND44; B2RAY7; hsa:56893; Q5VYA0; Q5VYA1; Q9BR98; Q9NRR5; Q9UHX4" "" "" "0" "0" "0.996" "1.032" "1.025" "1.190" "1.046" "1.004" "1.207" "1.087" "0.559" "138.2" "137.7" "142.7" "141.7" "164.5" "144.6" "138.8" "166.8" "150.2" "77.3" "" "" "" "" "" "" "" "" "" "" "82.7" "71.5" "79.0" "66.5" "76.2" "74.0" "64.6" "74.9" "81.5" "77.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1852571755298916304" "False" "High" "IsMasterProtein" "Q9UKX7" "Nuclear pore complex protein Nup50 OS=Homo sapiens OX=9606 GN=NUP50 PE=1 SV=2" "0.000" "False" "35.421" "22" "10" "17" "10" "468" "50.1" "7.06" "53.57" "10" "transport" "other membranes;nucleus" "" "Pf00638, Pf08911" "10762" "ENSG00000093000" "NUP50" "B1AHA4; B2RB15; hsa:10762; O75644; Q8N6V5; Q9NPM9; Q9NPR6; Q9P1K5; Q9UKX7" "" "Rev-mediated nuclear export of HIV RNA; SUMOylation of DNA replication proteins; Regulation of HSF1-mediated heat shock response; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "28" "0" "1.051" "1.055" "0.977" "1.055" "0.989" "1.044" "1.065" "1.058" "0.714" "1070.5" "1125.0" "1129.9" "1045.8" "1129.1" "1059.0" "1117.9" "1140.1" "1132.6" "763.8" "" "" "" "" "" "" "" "" "" "" "640.7" "584.6" "625.7" "491.0" "523.4" "542.1" "519.8" "511.9" "614.5" "763.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2410269861090895387" "False" "High" "IsMasterProtein" "Q9NZT2" "Opioid growth factor receptor OS=Homo sapiens OX=9606 GN=OGFR PE=1 SV=3" "0.000" "False" "35.344" "14" "7" "7" "7" "677" "73.3" "4.84" "23.84" "7" "other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf04664, Pf04680" "11054" "ENSG00000060491" "OGFR" "hsa:11054; O96029; Q4VXW5; Q96CM2; Q9BQW1; Q9H4H0; Q9H7J5; Q9NZT2; Q9NZT3; Q9NZT4" "" "" "0" "0" "1.101" "1.041" "1.052" "1.110" "1.109" "1.127" "0.828" "1.039" "5.096" "124.8" "137.4" "129.9" "131.3" "138.6" "138.4" "140.7" "103.4" "129.7" "636.1" "" "" "" "" "" "" "" "" "" "" "74.7" "71.4" "72.0" "61.6" "64.2" "70.8" "65.4" "46.4" "70.4" "636.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6388610480367959150" "False" "High" "IsMasterProtein" "O15446" "DNA-directed RNA polymerase I subunit RPA34 OS=Homo sapiens OX=9606 GN=POLR1G PE=1 SV=1" "0.000" "False" "35.311" "17" "6" "13" "6" "510" "55.0" "8.51" "34.93" "6" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf08208" "10849" "ENSG00000117877" "POLR1G" "hsa:10849; O15446; Q32N11; Q7Z5U2; Q9UPF6" "2q13 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "6" "0" "1.045" "1.048" "1.006" "1.000" "1.060" "1.043" "1.061" "1.044" "0.668" "461.2" "482.0" "483.3" "464.1" "461.0" "488.9" "481.2" "489.2" "481.4" "308.0" "" "" "" "" "" "" "" "" "" "" "276.0" "250.5" "267.6" "217.9" "213.7" "250.3" "223.7" "219.6" "261.2" "308.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5156803787758571728" "False" "High" "IsMasterProtein" "Q14444" "Caprin-1 OS=Homo sapiens OX=9606 GN=CAPRIN1 PE=1 SV=2" "0.000" "False" "35.089" "9" "7" "25" "7" "709" "78.3" "5.25" "68.41" "7" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf12287, Pf18293" "4076" "ENSG00000135387" "CAPRIN1" "A6NMY7; D3DR06; hsa:4076; Q14444; Q15074; Q6IMN4; Q6IMN7; Q9BV09" "" "" "0" "0" "1.109" "1.038" "1.011" "1.088" "1.076" "1.177" "1.168" "1.125" "0.714" "1904.5" "2112.3" "1977.3" "1924.6" "2072.6" "2049.0" "2241.2" "2225.2" "2141.7" "1359.4" "" "" "" "" "" "" "" "" "" "" "1139.7" "1097.7" "1095.0" "903.5" "960.7" "1048.9" "1042.1" "999.0" "1162.0" "1359.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4709536422529614216" "False" "High" "IsMasterProtein" "P20618" "Proteasome subunit beta type-1 OS=Homo sapiens OX=9606 GN=PSMB1 PE=1 SV=2" "0.000" "False" "35.001" "36" "9" "22" "9" "241" "26.5" "8.13" "60.75" "9" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227" "5689" "ENSG00000008018" "PSMB1" "B5BU76; hsa:5689; P20618; Q9BWA8" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Neutrophil degranulation" "63" "0" "1.028" "1.060" "1.088" "1.109" "1.064" "1.050" "1.172" "1.082" "0.771" "1407.5" "1446.4" "1491.4" "1531.0" "1561.4" "1497.8" "1478.4" "1649.7" "1522.8" "1085.1" "" "" "" "" "" "" "" "" "" "" "842.3" "751.6" "825.9" "718.8" "723.7" "766.8" "687.4" "740.6" "826.2" "1085.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7328219287373480262" "False" "High" "IsMasterProtein" "Q7LG56" "Ribonucleoside-diphosphate reductase subunit M2 B OS=Homo sapiens OX=9606 GN=RRM2B PE=1 SV=1" "0.000" "False" "34.998" "21" "7" "13" "5" "351" "40.7" "4.97" "37.76" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00268" "50484" "ENSG00000048392" "RRM2B" "B4E2N4; hsa:50484; Q17R22; Q75PQ6; Q75PQ7; Q75PY8; Q75PY9; Q7LG56; Q86YE3; Q9NPD6; Q9NTD8; Q9NUW3" "miRNA regulation of DNA damage response; Pyrimidine metabolism; p53 transcriptional gene network; DNA damage response" "Interconversion of nucleotide di- and triphosphates; TP53 Regulates Metabolic Genes" "6" "0" "1.080" "0.996" "0.962" "0.978" "0.986" "1.055" "1.083" "1.002" "0.605" "826.5" "892.7" "822.9" "794.9" "808.1" "814.9" "871.7" "895.3" "828.4" "500.2" "" "" "" "" "" "" "" "" "" "" "494.6" "463.9" "455.7" "373.2" "374.6" "417.2" "405.3" "401.9" "449.4" "500.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6888826320597161834" "False" "High" "IsMasterProtein" "Q16630" "Cleavage and polyadenylation specificity factor subunit 6 OS=Homo sapiens OX=9606 GN=CPSF6 PE=1 SV=2" "0.000" "False" "34.967" "19" "9" "25" "9" "551" "59.2" "7.15" "53.32" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00076" "11052" "ENSG00000111605" "CPSF6" "A8K7K9; hsa:11052; Q16630; Q53ES1; Q9BSJ7; Q9BW18" "" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "2" "0" "1.110" "1.047" "1.142" "1.149" "1.027" "1.055" "1.102" "1.087" "0.725" "672.4" "746.3" "704.2" "767.8" "772.3" "690.7" "709.1" "741.0" "731.1" "487.7" "" "" "" "" "" "" "" "" "" "" "402.4" "387.8" "390.0" "360.5" "358.0" "353.6" "329.7" "332.7" "396.6" "487.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8500687369034294287" "False" "High" "IsMasterProtein" "P62820" "Ras-related protein Rab-1A OS=Homo sapiens OX=9606 GN=RAB1A PE=1 SV=3" "0.000" "False" "34.964" "34" "7" "37" "1" "205" "22.7" "6.21" "91.09" "7" "cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5861" "ENSG00000138069" "RAB1A" "hsa:5861; P11476; P62820; Q6FIE7; Q96N61; Q9Y3T2" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization" "6" "3" "1.049" "0.999" "0.989" "0.870" "1.093" "1.041" "1.160" "1.028" "0.778" "522.7" "548.2" "522.1" "517.0" "454.9" "571.5" "543.9" "606.5" "537.6" "406.4" "" "" "" "" "" "" "" "" "" "" "312.8" "284.9" "289.1" "242.7" "210.9" "292.6" "252.9" "272.3" "291.7" "406.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6664537344047956195" "False" "High" "IsMasterProtein" "Q08209" "Protein phosphatase 3 catalytic subunit alpha OS=Homo sapiens OX=9606 GN=PPP3CA PE=1 SV=1" "0.000" "False" "34.939" "17" "9" "21" "5" "521" "58.7" "5.86" "55.56" "9" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149" "5530" "ENSG00000138814" "PPP3CA" "A1A441; A8K3B7; A8W6Z7; A8W6Z8; B5BUA2; hsa:5530; Q08209; Q8TAW9" "Physiological and pathological hypertrophy of the heart; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; G protein signaling pathways; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Serotonin and anxiety-related events; Serotonin and anxiety; Wnt signaling; Vitamin D in inflammatory diseases; Fragile X syndrome; Alzheimer's disease; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "FCERI mediated Ca+2 mobilization; CLEC7A (Dectin-1) induces NFAT activation; DARPP-32 events; Ca2+ pathway; Calcineurin activates NFAT" "26" "3" "1.058" "1.000" "1.079" "1.074" "0.924" "1.141" "1.024" "1.121" "0.789" "761.6" "805.6" "761.9" "821.5" "817.8" "704.0" "868.7" "780.0" "853.4" "601.2" "" "" "" "" "" "" "" "" "" "" "455.8" "418.7" "421.9" "385.7" "379.1" "360.4" "403.9" "350.2" "463.0" "601.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5466542288326959120" "False" "High" "IsMasterProtein" "P59998" "Actin-related protein 2/3 complex subunit 4 OS=Homo sapiens OX=9606 GN=ARPC4 PE=1 SV=3" "0.000" "False" "34.931" "41" "6" "47" "6" "168" "19.7" "8.43" "116.38" "6" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf05856" "10093" "ENSG00000241553" "ARPC4" "C9JWM7; E7ETI0; F6TTL5; hsa:10093; O15509; P59998; Q6P0W5; Q96QJ3" "Pathogenic Escherichia coli infection" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "6" "0" "0.987" "1.021" "1.035" "0.981" "1.092" "1.048" "1.085" "1.008" "0.685" "2197.5" "2169.4" "2244.3" "2273.6" "2156.3" "2400.1" "2303.8" "2384.4" "2215.6" "1504.3" "" "" "" "" "" "" "" "" "" "" "1315.1" "1127.4" "1242.8" "1067.4" "999.5" "1228.7" "1071.2" "1070.5" "1202.1" "1504.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5070657134179306573" "False" "High" "IsMasterProtein" "P55160" "Nck-associated protein 1-like OS=Homo sapiens OX=9606 GN=NCKAP1L PE=1 SV=3" "0.000" "False" "34.903" "11" "11" "17" "11" "1127" "128.1" "6.86" "37.33" "11" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf09735" "3071" "ENSG00000123338" "NCKAP1L" "B4DUT5; hsa:3071; P55160; Q52LW0" "Hematopoietic stem cell differentiation; Microglia pathogen phagocytosis pathway; TYROBP causal network in microglia" "Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "11" "0" "1.036" "1.062" "1.126" "1.141" "1.227" "1.186" "1.009" "1.161" "2.353" "508.2" "526.6" "539.5" "572.4" "579.7" "623.7" "602.8" "512.8" "590.0" "1195.6" "" "" "" "" "" "" "" "" "" "" "304.1" "273.6" "298.8" "268.7" "268.7" "319.3" "280.3" "230.2" "320.1" "1195.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6990547013884615551" "False" "High" "IsMasterProtein" "Q5JSH3" "WD repeat-containing protein 44 OS=Homo sapiens OX=9606 GN=WDR44 PE=1 SV=1" "0.000" "False" "34.869" "12" "8" "10" "8" "913" "101.3" "5.45" "27.89" "8" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "54521" "ENSG00000131725" "WDR44" "B4DSE9; F8W913; hsa:54521; Q0JS52; Q0JTF3; Q5JSH2; Q5JSH3; Q6ZSC1; Q7Z365; Q7Z3P6; Q8NAU8; Q8NHU5; Q9NUV4" "Ectoderm differentiation" "" "1" "0" "1.053" "1.034" "1.000" "1.041" "1.055" "1.076" "1.158" "0.980" "0.696" "353.9" "372.8" "365.9" "354.0" "368.4" "373.3" "380.8" "409.7" "346.7" "246.3" "" "" "" "" "" "" "" "" "" "" "211.8" "193.7" "202.6" "166.2" "170.7" "191.1" "177.1" "183.9" "188.1" "246.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8677465183251509063" "False" "High" "IsMasterProtein" "Q9NX55" "Huntingtin-interacting protein K OS=Homo sapiens OX=9606 GN=HYPK PE=1 SV=3" "0.000" "False" "34.818" "42" "6" "19" "6" "121" "13.6" "4.82" "42.24" "6" "protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf19026" "25764" "ENSG00000242028" "HYPK" "C9JKJ0; hsa:25764; O75408; Q8WUW8; Q9NX55; Q9P024" "" "" "0" "0" "1.101" "1.020" "1.025" "1.016" "0.968" "0.922" "0.987" "0.928" "0.561" "1196.2" "1316.5" "1220.0" "1226.6" "1215.7" "1157.4" "1102.9" "1180.9" "1110.2" "671.4" "" "" "" "" "" "" "" "" "" "" "715.9" "684.1" "675.6" "575.8" "563.5" "592.5" "512.8" "530.2" "602.3" "671.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8415712224574136193" "False" "High" "IsMasterProtein" "P26196" "Probable ATP-dependent RNA helicase DDX6 OS=Homo sapiens OX=9606 GN=DDX6 PE=1 SV=2" "0.000" "False" "34.756" "24" "10" "18" "10" "483" "54.4" "8.66" "37.72" "10" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1656" "ENSG00000110367" "DDX6" "hsa:1656; P26196; Q5D048" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "1.008" "0.963" "1.052" "1.132" "1.051" "1.086" "1.019" "1.100" "1.582" "479.7" "483.8" "462.1" "504.7" "543.2" "504.2" "521.2" "488.9" "527.7" "758.9" "" "" "" "" "" "" "" "" "" "" "287.1" "251.4" "255.9" "236.9" "251.8" "258.1" "242.3" "219.5" "286.3" "758.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1585168671336988915" "False" "High" "IsMasterProtein" "Q01433" "AMP deaminase 2 OS=Homo sapiens OX=9606 GN=AMPD2 PE=1 SV=3" "0.000" "False" "34.752" "13" "11" "15" "11" "825" "94.8" "6.55" "39.50" "11" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf19326" "271" "ENSG00000116337" "AMPD2" "A0A5F9UK94; B4DK50; B4DZI5; E9PNG0; hsa:271; Q01433; Q14856; Q14857; Q16686; Q16687; Q16688; Q16729; Q5T693; Q5T695; Q96IA1; Q9UDX8; Q9UDX9; Q9UMU4" "" "Purine salvage" "1" "0" "1.077" "0.996" "1.076" "1.135" "1.036" "1.107" "1.068" "1.088" "0.847" "522.6" "562.9" "520.4" "562.1" "593.4" "541.4" "578.5" "558.4" "568.8" "442.8" "" "" "" "" "" "" "" "" "" "" "312.8" "292.5" "288.2" "263.9" "275.0" "277.1" "269.0" "250.7" "308.6" "442.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "875070389354990237" "False" "High" "IsMasterProtein" "O00273" "DNA fragmentation factor subunit alpha OS=Homo sapiens OX=9606 GN=DFFA PE=1 SV=1" "0.000" "False" "34.679" "24" "7" "18" "7" "331" "36.5" "4.79" "48.07" "7" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02017, Pf09033" "1676" "ENSG00000160049" "DFFA" "hsa:1676; O00273; Q5T6G5; Q5T6G6; Q96I97; Q9Y6C6" "Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis" "Apoptosis induced DNA fragmentation" "4" "0" "1.077" "1.030" "1.044" "1.027" "1.014" "1.082" "1.064" "1.082" "0.684" "697.5" "751.2" "718.4" "728.2" "716.2" "707.4" "754.4" "742.4" "754.6" "477.4" "" "" "" "" "" "" "" "" "" "" "417.4" "390.4" "397.9" "341.9" "332.0" "362.2" "350.8" "333.3" "409.4" "477.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6099589946817253427" "False" "High" "IsMasterProtein" "Q7Z417" "FMR1-interacting protein NUFIP2 OS=Homo sapiens OX=9606 GN=NUFIP2 PE=1 SV=1" "0.000" "False" "34.678" "16" "8" "11" "8" "695" "76.1" "8.70" "34.68" "8" "" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf15293" "57532" "ENSG00000108256" "NUFIP2" "A1L3A6; A1L3A7; hsa:57532; Q7Z417; Q9P2M5" "" "" "0" "0" "0.975" "1.005" "0.984" "1.002" "1.047" "0.888" "0.997" "1.017" "0.725" "276.8" "269.9" "278.3" "272.5" "277.3" "289.9" "245.7" "275.9" "281.5" "200.8" "" "" "" "" "" "" "" "" "" "" "165.7" "140.3" "154.1" "127.9" "128.5" "148.4" "114.3" "123.9" "152.7" "200.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4414098033661647234" "False" "High" "IsMasterProtein" "O43488" "Aflatoxin B1 aldehyde reductase member 2 OS=Homo sapiens OX=9606 GN=AKR7A2 PE=1 SV=3" "0.000" "False" "34.598" "21" "7" "27" "7" "359" "39.6" "7.17" "59.04" "7" "other metabolic processes" "cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00248" "8574" "ENSG00000053371" "AKR7A2" "hsa:8574; O43488; O75749; Q5TG63" "Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II" "Aflatoxin activation and detoxification" "3" "0" "0.967" "0.928" "1.021" "0.986" "0.999" "0.966" "0.988" "0.971" "0.748" "1521.2" "1471.7" "1411.4" "1553.3" "1499.3" "1519.8" "1469.2" "1503.5" "1477.7" "1137.4" "" "" "" "" "" "" "" "" "" "" "910.4" "764.8" "781.6" "729.2" "694.9" "778.0" "683.1" "675.0" "801.7" "1137.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8725302829576246174" "False" "High" "IsMasterProtein" "P63151" "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R2A PE=1 SV=1" "0.000" "False" "34.585" "20" "9" "25" "7" "447" "51.7" "6.20" "46.29" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "" "5520" "ENSG00000221914" "PPP2R2A" "B2RBU8; B4E1T7; hsa:5520; P50409; P63151; Q00007" "Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; Initiation of Nuclear Envelope (NE) Reformation" "7" "1" "1.062" "1.089" "1.065" "0.996" "1.038" "1.026" "1.114" "1.095" "0.826" "1373.1" "1458.3" "1496.0" "1462.5" "1367.3" "1425.5" "1408.5" "1529.7" "1502.9" "1133.8" "" "" "" "" "" "" "" "" "" "" "821.7" "757.8" "828.4" "686.6" "633.8" "729.7" "654.9" "686.7" "815.4" "1133.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1695167521897825927" "False" "High" "IsMasterProtein" "P53609" "Geranylgeranyl transferase type-1 subunit beta OS=Homo sapiens OX=9606 GN=PGGT1B PE=1 SV=2" "0.000" "False" "34.577" "25" "9" "11" "9" "377" "42.3" "6.83" "32.84" "9" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00432" "5229" "ENSG00000164219" "PGGT1B" "hsa:5229; P53609; Q5MJP9" "" "" "0" "0" "1.109" "1.150" "1.219" "1.105" "1.203" "1.088" "1.215" "1.116" "0.998" "817.0" "906.1" "939.3" "996.1" "902.8" "983.0" "889.0" "992.9" "912.1" "815.4" "" "" "" "" "" "" "" "" "" "" "488.9" "470.9" "520.1" "467.6" "418.5" "503.2" "413.4" "445.7" "494.9" "815.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174444924925407144" "False" "High" "IsMasterProtein" "P61088" "Ubiquitin-conjugating enzyme E2 N OS=Homo sapiens OX=9606 GN=UBE2N PE=1 SV=1" "0.000" "False" "34.546" "45" "7" "29" "7" "152" "17.1" "6.57" "72.19" "7" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00179" "7334" "ENSG00000177889" "UBE2N" "hsa:7334; P61088; Q16781; Q53Y81" "IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway; Prader-Willi and Angelman syndrome; 3q29 copy number variation syndrome" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; Aggrephagy; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; Nonhomologous End-Joining (NHEJ); Formation of Incision Complex in GG-NER; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "28" "0" "1.048" "1.078" "1.013" "1.023" "1.010" "1.005" "1.023" "1.044" "1.092" "1213.5" "1271.5" "1308.3" "1229.4" "1241.1" "1225.4" "1220.1" "1241.2" "1267.2" "1324.8" "" "" "" "" "" "" "" "" "" "" "726.2" "660.8" "724.5" "577.2" "575.3" "627.3" "567.3" "557.2" "687.5" "1324.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4785395366368004219" "False" "High" "IsMasterProtein" "Q15274" "Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Homo sapiens OX=9606 GN=QPRT PE=1 SV=3" "0.000" "False" "34.353" "23" "6" "9" "6" "297" "30.8" "6.21" "28.96" "6" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01729, Pf02749" "23475" "ENSG00000103485" "QPRT" "hsa:23475; Q15274; Q53XW7; Q96G22; Q9BSG6" "NAD biosynthesis II (from tryptophan); NAD+ biosynthetic pathways; 16p11.2 proximal deletion syndrome; Kynurenine pathway and links to cell senescence" "Nicotinate metabolism" "5" "0" "0.992" "0.938" "1.043" "0.967" "0.952" "0.961" "1.005" "0.945" "0.620" "687.7" "681.9" "645.4" "717.2" "665.0" "654.6" "661.1" "691.2" "650.1" "426.6" "" "" "" "" "" "" "" "" "" "" "411.6" "354.4" "357.4" "336.7" "308.2" "335.1" "307.4" "310.3" "352.7" "426.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7968684939462891772" "False" "High" "IsMasterProtein" "O14974" "Protein phosphatase 1 regulatory subunit 12A OS=Homo sapiens OX=9606 GN=PPP1R12A PE=1 SV=1" "0.000" "False" "34.350" "10" "11" "14" "11" "1030" "115.2" "5.40" "38.15" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf15898" "4659" "ENSG00000058272" "PPP1R12A" "B4DZ09; F8VWB4; hsa:4659; O14974; Q2NKL4; Q569H0; Q86WU3; Q8NFR6; Q9BYH0" "Focal adhesion; Hippo-Merlin signaling dysregulation; Regulation of actin cytoskeleton" "Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "8" "0" "1.081" "1.079" "1.021" "1.098" "0.967" "1.039" "0.987" "1.079" "1.960" "470.2" "508.3" "507.5" "480.1" "516.3" "454.7" "488.5" "464.0" "507.2" "921.7" "" "" "" "" "" "" "" "" "" "" "281.4" "264.1" "281.0" "225.4" "239.3" "232.8" "227.1" "208.3" "275.2" "921.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3453678624484122586" "False" "High" "IsMasterProtein" "Q8WUM4" "Programmed cell death 6-interacting protein OS=Homo sapiens OX=9606 GN=PDCD6IP PE=1 SV=1" "0.000" "False" "34.202" "11" "10" "11" "10" "868" "96.0" "6.52" "29.55" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf03097, Pf13949" "10015" "ENSG00000170248" "PDCD6IP" "C5MQH7; E9PFU1; hsa:10015; Q6NUS1; Q8WUM4; Q9BX86; Q9NUN0; Q9P2H2; Q9UKL5" "Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells" "Budding and maturation of HIV virion; Regulation of necroptotic cell death; Uptake and function of anthrax toxins" "5" "0" "1.008" "1.010" "1.068" "0.962" "1.075" "1.137" "0.558" "1.205" "7.224" "151.8" "153.0" "153.3" "162.1" "146.1" "163.2" "172.6" "84.7" "182.9" "1096.5" "" "" "" "" "" "" "" "" "" "" "90.8" "79.5" "84.9" "76.1" "67.7" "83.5" "80.3" "38.0" "99.2" "1096.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9033578792166200150" "False" "High" "IsMasterProtein" "Q99729" "Heterogeneous nuclear ribonucleoprotein A/B OS=Homo sapiens OX=9606 GN=HNRNPAB PE=1 SV=2" "0.000" "False" "34.195" "25" "8" "29" "8" "332" "36.2" "8.21" "62.19" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08143" "3182" "ENSG00000197451" "HNRNPAB" "B3KNN5; D3DWP7; hsa:3182; Q04150; Q8N7U3; Q99729; Q9BQ99" "Pre-implantation embryo; mRNA processing" "" "2" "0" "0.956" "0.997" "1.005" "1.088" "1.150" "1.027" "1.211" "1.024" "0.586" "1898.6" "1815.5" "1892.5" "1908.1" "2065.1" "2183.4" "1950.6" "2299.8" "1943.2" "1112.6" "" "" "" "" "" "" "" "" "" "" "1136.2" "943.4" "1048.0" "895.8" "957.2" "1117.7" "907.0" "1032.5" "1054.3" "1112.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5390020710088679993" "False" "High" "IsMasterProtein" "O75368" "Adapter SH3BGRL OS=Homo sapiens OX=9606 GN=SH3BGRL PE=1 SV=1" "0.000" "False" "34.159" "46" "6" "34" "6" "114" "12.8" "5.25" "110.42" "6" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04908" "6451" "ENSG00000131171" "SH3BGRL" "hsa:6451; O75368; Q3SYL1; Q5JT50; Q6FIE8; Q9H0N8" "" "" "0" "0" "0.967" "0.998" "0.828" "0.962" "1.031" "0.855" "1.017" "0.890" "0.499" "2935.2" "2838.3" "2928.4" "2429.4" "2824.2" "3024.8" "2510.9" "2984.7" "2610.9" "1463.6" "" "" "" "" "" "" "" "" "" "" "1756.6" "1474.9" "1621.7" "1140.5" "1309.1" "1548.5" "1167.5" "1340.0" "1416.5" "1463.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3985188646102169391" "False" "High" "IsMasterProtein" "P53041" "Serine/threonine-protein phosphatase 5 OS=Homo sapiens OX=9606 GN=PPP5C PE=1 SV=1" "0.000" "False" "34.118" "16" "7" "17" "7" "499" "56.8" "6.28" "44.54" "7" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00149, Pf00515, Pf08321" "5536" "ENSG00000011485" "PPP5C" "hsa:5536; P53041; Q16722; Q53XV2" "MAPK signaling pathway; ATM signaling in development and disease" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Negative regulation of MAPK pathway; ESR-mediated signaling" "5" "0" "1.108" "1.204" "1.047" "1.029" "0.985" "1.131" "1.033" "1.103" "1.423" "394.2" "436.8" "474.7" "412.6" "405.8" "388.3" "445.7" "407.1" "434.9" "560.8" "" "" "" "" "" "" "" "" "" "" "235.9" "227.0" "262.9" "193.7" "188.1" "198.8" "207.3" "182.8" "235.9" "560.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "508361359361041752" "False" "High" "IsMasterProtein" "O00193" "Small acidic protein OS=Homo sapiens OX=9606 GN=SMAP PE=1 SV=1" "0.000" "False" "34.082" "36" "4" "15" "4" "183" "20.3" "4.72" "57.03" "4" "" "" "" "Pf15477" "10944" "ENSG00000110696" "SMAP" "B2RD28; hsa:10944; O00193" "" "" "0" "0" "1.059" "1.061" "1.068" "1.168" "1.146" "1.061" "1.265" "1.080" "0.422" "1124.0" "1190.0" "1193.1" "1200.2" "1312.4" "1287.9" "1193.0" "1421.9" "1213.6" "474.9" "" "" "" "" "" "" "" "" "" "" "672.7" "618.4" "660.7" "563.5" "608.3" "659.3" "554.7" "638.3" "658.4" "474.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200158126373336546" "False" "High" "IsMasterProtein" "Q6IBS0" "Twinfilin-2 OS=Homo sapiens OX=9606 GN=TWF2 PE=1 SV=2" "0.000" "False" "34.060" "24" "7" "13" "6" "349" "39.5" "6.84" "38.18" "7" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "11344" "ENSG00000247596" "TWF2" "hsa:11344; Q6IBS0; Q9Y3F5" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "2" "1" "1.139" "1.273" "1.174" "1.035" "1.241" "1.037" "1.261" "1.155" "1.215" "844.9" "962.7" "1075.6" "991.8" "874.1" "1048.4" "876.3" "1065.2" "976.1" "1026.7" "" "" "" "" "" "" "" "" "" "" "505.6" "500.3" "595.7" "465.6" "405.2" "536.7" "407.4" "478.2" "529.6" "1026.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8396121455567897427" "False" "High" "IsMasterProtein" "Q9Y4K1" "Beta/gamma crystallin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CRYBG1 PE=1 SV=4" "0.000" "False" "33.994" "5" "8" "9" "8" "2131" "231.6" "5.81" "27.08" "8" "" "" "other molecular function" "Pf00030, Pf00652" "" "ENSG00000112297" "CRYBG1" "A0A0J9YWL0" "" "" "0" "0" "1.177" "1.086" "0.984" "1.188" "1.106" "1.081" "1.068" "1.056" "1.149" "271.8" "319.9" "295.1" "267.5" "322.8" "300.6" "293.9" "290.2" "287.0" "312.2" "" "" "" "" "" "" "" "" "" "" "162.6" "166.2" "163.4" "125.6" "149.6" "153.9" "136.6" "130.3" "155.7" "312.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9165342661713370894" "False" "High" "IsMasterProtein" "Q969U7" "Proteasome assembly chaperone 2 OS=Homo sapiens OX=9606 GN=PSMG2 PE=1 SV=1" "0.000" "False" "33.981" "34" "10" "26" "10" "264" "29.4" "6.98" "46.23" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf09754" "56984" "ENSG00000128789" "PSMG2" "B0YJB3; hsa:56984; Q6IAH4; Q969U7; Q9NRV1; V9GYH7" "" "" "0" "0" "0.966" "0.921" "0.975" "1.006" "1.123" "0.982" "1.050" "0.995" "0.725" "1054.6" "1019.1" "971.4" "1028.6" "1061.0" "1184.2" "1035.2" "1107.7" "1049.7" "764.9" "" "" "" "" "" "" "" "" "" "" "631.1" "529.6" "537.9" "482.9" "491.8" "606.2" "481.3" "497.3" "569.5" "764.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1880293335037512275" "False" "High" "IsMasterProtein" "E9PAV3" "Nascent polypeptide-associated complex subunit alpha, muscle-specific form OS=Homo sapiens OX=9606 GN=NACA PE=1 SV=1" "0.000" "False" "33.980" "2" "4" "26" "4" "2078" "205.3" "9.58" "61.32" "4" "other biological processes" "translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01849, Pf19026" "" "ENSG00000196531" "NACA" "E9PAV3" "" "" "0" "0" "0.982" "0.866" "0.928" "0.997" "0.996" "1.007" "1.053" "1.016" "0.586" "1303.6" "1279.9" "1128.3" "1209.6" "1299.1" "1298.6" "1312.2" "1372.2" "1324.0" "763.6" "" "" "" "" "" "" "" "" "" "" "780.1" "665.1" "624.8" "567.9" "602.2" "664.8" "610.1" "616.0" "718.3" "763.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4976528031312254709" "False" "High" "IsMasterProtein" "Q92506" "(3R)-3-hydroxyacyl-CoA dehydrogenase OS=Homo sapiens OX=9606 GN=HSD17B8 PE=1 SV=2" "0.000" "False" "33.947" "27" "6" "17" "6" "261" "27.0" "6.54" "44.13" "6" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf13561" "7923" "ENSG00000112474; ENSG00000204228; ENSG00000225312; ENSG00000228357; ENSG00000228712; ENSG00000232357" "HSD17B8" "A6NLX7; hsa:7923; Q5STP7; Q92506; Q9UIQ1" "" "Fatty acyl-CoA biosynthesis" "1" "0" "0.995" "0.970" "1.132" "0.971" "0.952" "1.014" "0.983" "0.886" "0.671" "453.9" "451.6" "440.4" "513.9" "440.8" "432.0" "460.5" "446.3" "402.3" "304.5" "" "" "" "" "" "" "" "" "" "" "271.7" "234.7" "243.9" "241.2" "204.3" "221.2" "214.1" "200.4" "218.3" "304.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1845786618234347704" "False" "High" "IsMasterProtein" "P55263" "Adenosine kinase OS=Homo sapiens OX=9606 GN=ADK PE=1 SV=2" "0.000" "False" "33.865" "24" "7" "16" "7" "362" "40.5" "6.70" "49.52" "7" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus" "kinase activity;other molecular function" "Pf00294" "132" "ENSG00000156110" "ADK" "B7Z783; B7Z800; hsa:132; O00741; O00742; P55263; Q16710; Q5JQ10; Q5JQ11; Q9BTN2" "Methionine metabolism leading to sulfur amino acids and related disorders" "Ribavirin ADME; Purine salvage" "3" "0" "0.873" "0.872" "0.940" "0.884" "0.908" "0.884" "0.947" "0.886" "0.719" "1156.2" "1009.5" "1007.9" "1086.4" "1021.8" "1050.1" "1022.4" "1094.3" "1024.1" "830.7" "" "" "" "" "" "" "" "" "" "" "691.9" "524.6" "558.2" "510.1" "473.6" "537.6" "475.4" "491.3" "555.6" "830.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8882666347281850930" "False" "High" "IsMasterProtein" "P48739" "Phosphatidylinositol transfer protein beta isoform OS=Homo sapiens OX=9606 GN=PITPNB PE=1 SV=2" "0.000" "False" "33.840" "27" "8" "18" "6" "271" "31.5" "6.87" "53.86" "8" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf02121" "23760" "ENSG00000180957" "PITPNB" "B3KYB8; B7Z7Q0; hsa:23760; P48739; Q8N5W1" "" "PI and PC transport between ER and Golgi membranes" "1" "0" "1.116" "1.157" "1.095" "1.248" "1.081" "1.196" "1.083" "1.114" "1.056" "478.8" "534.3" "554.2" "524.5" "597.5" "517.5" "572.8" "518.6" "533.2" "505.9" "" "" "" "" "" "" "" "" "" "" "286.6" "277.6" "306.9" "246.2" "277.0" "264.9" "266.3" "232.8" "289.3" "505.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6973941838255417452" "False" "High" "IsMasterProtein" "P56192" "Methionine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=MARS1 PE=1 SV=2" "0.000" "False" "33.792" "12" "10" "16" "10" "900" "101.1" "6.16" "45.07" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00043, Pf00458, Pf09334, Pf18485, Pf19303" "4141" "ENSG00000166986" "MARS1" "B3KVK7; hsa:4141; P56192; Q14895; Q53H14; Q96A15; Q96BZ0; Q9NSE0" "" "Cytosolic tRNA aminoacylation; Selenoamino acid metabolism" "2" "0" "0.941" "0.975" "1.039" "1.119" "1.099" "1.162" "0.606" "1.047" "5.730" "467.3" "439.5" "455.7" "485.7" "523.0" "513.5" "542.9" "283.0" "489.1" "2677.5" "" "" "" "" "" "" "" "" "" "" "279.7" "228.4" "252.4" "228.0" "242.4" "262.9" "252.4" "127.1" "265.4" "2677.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5006297447401564784" "False" "High" "IsMasterProtein" "Q96B23" "Protein ARK2N OS=Homo sapiens OX=9606 GN=ARK2N PE=1 SV=3" "0.000" "False" "33.753" "14" "4" "7" "4" "404" "43.4" "4.88" "22.81" "4" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15303" "147339" "ENSG00000152242" "ARK2N" "A8K123; A8KAB6; hsa:147339; Q5BIX2; Q5XG78; Q6N058; Q86TB5; Q8TCQ5; Q96B23" "" "" "0" "0" "0.940" "0.915" "0.868" "0.996" "1.016" "0.984" "1.017" "0.933" "0.554" "556.2" "522.5" "508.6" "482.5" "553.9" "564.9" "547.2" "565.8" "519.1" "308.2" "" "" "" "" "" "" "" "" "" "" "332.8" "271.5" "281.7" "226.5" "256.8" "289.2" "254.4" "254.0" "281.6" "308.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6604733771635373365" "False" "High" "IsMasterProtein" "P84085" "ADP-ribosylation factor 5 OS=Homo sapiens OX=9606 GN=ARF5 PE=1 SV=2" "0.000" "False" "33.648" "31" "5" "40" "2" "180" "20.5" "6.79" "107.81" "5" "transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00025" "381" "ENSG00000004059" "ARF5" "hsa:381; P26437; P84085" "2q37 copy number variation syndrome" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "3" "0" "0.955" "0.976" "1.011" "1.193" "0.911" "1.142" "0.970" "1.026" "0.632" "300.8" "287.3" "293.6" "304.0" "358.7" "274.1" "343.5" "291.8" "308.5" "190.0" "" "" "" "" "" "" "" "" "" "" "180.0" "149.3" "162.6" "142.7" "166.3" "140.3" "159.7" "131.0" "167.4" "190.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1376480877538073283" "False" "High" "IsMasterProtein" "Q14232" "Translation initiation factor eIF2B subunit alpha OS=Homo sapiens OX=9606 GN=EIF2B1 PE=1 SV=1" "0.000" "False" "33.647" "32" "9" "25" "9" "305" "33.7" "7.33" "63.34" "9" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "1967" "ENSG00000111361" "EIF2B1" "A6NLY9; B4DGX0; hsa:1967; Q14232; Q3SXP4" "Translation factors" "Recycling of eIF2:GDP" "2" "0" "0.933" "0.946" "1.037" "0.982" "1.035" "0.992" "1.016" "0.978" "0.769" "1109.6" "1035.2" "1050.1" "1150.1" "1089.2" "1148.0" "1100.7" "1127.5" "1084.9" "853.6" "" "" "" "" "" "" "" "" "" "" "664.0" "538.0" "581.5" "540.0" "504.9" "587.7" "511.8" "506.2" "588.6" "853.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "879339039440763847" "False" "High" "IsMasterProtein" "A6NI72" "Putative neutrophil cytosol factor 1B OS=Homo sapiens OX=9606 GN=NCF1B PE=5 SV=2" "0.000" "False" "33.622" "24" "8" "18" "8" "391" "44.8" "9.13" "38.25" "8" "other metabolic processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00787, Pf08944, Pf16621" "" "" "NCF1B" "A6NI72" "" "" "0" "0" "1.088" "1.050" "1.137" "1.132" "1.079" "1.185" "0.587" "0.948" "4.405" "121.1" "131.7" "127.1" "137.6" "137.0" "130.6" "143.5" "71.1" "114.8" "533.3" "" "" "" "" "" "" "" "" "" "" "72.4" "68.5" "70.4" "64.6" "63.5" "66.9" "66.7" "31.9" "62.3" "533.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8106966376198238351" "False" "High" "IsMasterProtein" "Q01844" "RNA-binding protein EWS OS=Homo sapiens OX=9606 GN=EWSR1 PE=1 SV=1" "0.000" "False" "33.593" "9" "4" "19" "4" "656" "68.4" "9.33" "48.80" "4" "" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00076, Pf00641" "2130" "ENSG00000182944" "EWSR1" "B0QYK1; hsa:2130; Q01844; Q5THL0; Q92635; Q96FE8; Q96MN4; Q96MX4; Q9BWA2" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.980" "0.934" "0.901" "1.037" "1.015" "1.040" "1.085" "0.985" "0.512" "732.7" "717.9" "684.1" "660.2" "759.8" "743.6" "762.2" "795.3" "721.9" "374.9" "" "" "" "" "" "" "" "" "" "" "438.5" "373.0" "378.8" "310.0" "352.2" "380.6" "354.4" "357.1" "391.6" "374.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8135385361793162553" "False" "High" "IsMasterProtein" "Q9BQA1" "Methylosome protein WDR77 OS=Homo sapiens OX=9606 GN=WDR77 PE=1 SV=1" "0.000" "False" "33.575" "18" "5" "15" "5" "342" "36.7" "5.17" "46.54" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "79084" "ENSG00000116455" "WDR77" "B3KMW6; B4DP38; hsa:79084; Q3LID2; Q53FU2; Q6JZZ5; Q96GK4; Q9BQA1; Q9BWY3" "" "RMTs methylate histone arginines; snRNP Assembly" "2" "0" "0.937" "0.934" "1.136" "0.990" "0.991" "1.115" "1.072" "0.920" "0.757" "1003.6" "940.2" "937.7" "1140.4" "993.8" "994.3" "1119.4" "1076.0" "923.5" "759.3" "" "" "" "" "" "" "" "" "" "" "600.6" "488.6" "519.3" "535.4" "460.7" "509.0" "520.5" "483.1" "501.1" "759.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7978508680545557598" "False" "High" "IsMasterProtein" "Q1KMD3" "Heterogeneous nuclear ribonucleoprotein U-like protein 2 OS=Homo sapiens OX=9606 GN=HNRNPUL2 PE=1 SV=1" "0.000" "False" "33.538" "14" "10" "14" "10" "747" "85.1" "4.91" "29.14" "10" "" "nucleus;other cell component" "" "Pf00622, Pf02037, Pf13671" "221092" "ENSG00000214753" "HNRNPUL2" "hsa:221092; Q1KMD3; Q8N3B3" "" "" "0" "0" "1.113" "0.996" "1.054" "1.180" "0.959" "1.135" "0.376" "1.107" "6.233" "49.1" "54.7" "48.9" "51.7" "57.9" "47.1" "55.8" "18.5" "54.4" "306.1" "" "" "" "" "" "" "" "" "" "" "29.4" "28.4" "27.1" "24.3" "26.9" "24.1" "25.9" "8.3" "29.5" "306.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3673508278002205446" "False" "High" "IsMasterProtein" "P36542" "ATP synthase subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1C PE=1 SV=1" "0.000" "False" "33.468" "31" "9" "24" "9" "298" "33.0" "9.22" "67.40" "9" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf00231" "509" "ENSG00000165629" "ATP5F1C" "A8KA31; hsa:509; P36542; Q5VYP3; Q6I9V2; Q96AS8" "Electron transport chain: OXPHOS system in mitochondria" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "4" "0" "0.967" "0.948" "1.026" "0.985" "1.021" "0.967" "1.100" "1.022" "0.420" "2062.0" "1994.4" "1954.7" "2115.8" "2031.2" "2104.7" "1994.8" "2268.3" "2106.9" "865.4" "" "" "" "" "" "" "" "" "" "" "1234.0" "1036.4" "1082.5" "993.3" "941.5" "1077.5" "927.5" "1018.3" "1143.1" "865.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1088137077242897803" "False" "High" "IsMasterProtein" "P51659" "Peroxisomal multifunctional enzyme type 2 OS=Homo sapiens OX=9606 GN=HSD17B4 PE=1 SV=3" "0.000" "False" "33.452" "15" "10" "14" "10" "736" "79.6" "8.84" "34.63" "10" "other metabolic processes;developmental processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf00106, Pf01575, Pf02036" "3295" "ENSG00000133835" "HSD17B4" "B4DNV1; B4DVS5; E9PB82; F5HE57; hsa:3295; P51659" "Androgen receptor network in prostate cancer; Steroid biosynthesis; Disorders of bile acid synthesis and biliary transport; Primary ovarian insufficiency" "TYSND1 cleaves peroxisomal proteins; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids" "10" "0" "0.995" "1.060" "1.038" "1.220" "1.209" "1.070" "1.218" "1.401" "0.728" "671.0" "667.7" "711.4" "696.2" "818.8" "811.2" "718.3" "817.4" "939.7" "488.4" "" "" "" "" "" "" "" "" "" "" "401.5" "347.0" "394.0" "326.8" "379.6" "415.3" "334.0" "366.9" "509.8" "488.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5539470002617871814" "False" "High" "IsMasterProtein" "Q9P2R7" "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLA2 PE=1 SV=3" "0.000" "False" "33.401" "17" "8" "11" "8" "463" "50.3" "7.42" "29.54" "8" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00549, Pf08442" "8803" "ENSG00000136143" "SUCLA2" "B2RDE7; hsa:8803; O95194; Q5T9Q4; Q5T9Q6; Q9NV21; Q9NVP7; Q9P2R7" "" "Citric acid cycle (TCA cycle)" "1" "0" "1.093" "1.148" "1.194" "1.232" "1.205" "1.242" "0.719" "1.055" "5.535" "302.6" "330.6" "347.3" "361.3" "372.9" "364.7" "375.7" "217.5" "319.2" "1675.0" "" "" "" "" "" "" "" "" "" "" "181.1" "171.8" "192.3" "169.6" "172.9" "186.7" "174.7" "97.6" "173.2" "1675.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4128416838288873001" "False" "High" "IsMasterProtein" "P11177" "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=PDHB PE=1 SV=3" "0.000" "False" "33.378" "27" "9" "20" "9" "359" "39.2" "6.65" "52.05" "9" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf02779, Pf02780" "5162" "ENSG00000168291" "PDHB" "B2R7L0; B4DDD7; hsa:5162; P11177; Q6FH45; Q9BQ27; Q9UFK3" "Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Orexin receptor pathway" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "8" "0" "1.116" "1.063" "1.044" "1.094" "1.118" "1.208" "1.075" "1.326" "2.615" "486.9" "543.6" "517.5" "508.2" "532.7" "544.2" "588.2" "523.6" "645.6" "1273.0" "" "" "" "" "" "" "" "" "" "" "291.4" "282.5" "286.6" "238.6" "246.9" "278.6" "273.5" "235.1" "350.3" "1273.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7169835918379755143" "False" "High" "IsMasterProtein" "P39687" "Acidic leucine-rich nuclear phosphoprotein 32 family member A OS=Homo sapiens OX=9606 GN=ANP32A PE=1 SV=1" "0.000" "False" "33.330" "33" "8" "22" "5" "249" "28.6" "4.09" "51.61" "8" "transport;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf14580" "8125" "ENSG00000140350" "ANP32A" "B2R6T4; hsa:8125; P39687; Q53FK4; Q5J8L8; Q7M4N6" "IL-18 signaling pathway" "HuR (ELAVL1) binds and stabilizes mRNA" "2" "3" "0.962" "1.045" "0.877" "0.821" "0.868" "0.894" "0.827" "0.821" "0.711" "1347.5" "1296.8" "1408.2" "1182.4" "1106.6" "1170.1" "1205.1" "1114.1" "1107.0" "958.0" "" "" "" "" "" "" "" "" "" "" "806.4" "673.9" "779.8" "555.1" "512.9" "599.0" "560.4" "500.2" "600.6" "958.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5396921561883894054" "False" "High" "IsMasterProtein" "Q96GD0" "Chronophin OS=Homo sapiens OX=9606 GN=PDXP PE=1 SV=2" "0.000" "False" "33.250" "35" "9" "14" "9" "296" "31.7" "6.55" "34.94" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf13242, Pf13344" "57026" "ENSG00000241360" "PDXP" "hsa:57026; Q96GD0; Q9UGY2" "" "" "0" "0" "0.842" "0.850" "1.001" "0.877" "0.894" "0.996" "0.878" "0.863" "0.583" "712.5" "599.7" "605.6" "713.4" "624.7" "636.9" "709.4" "625.7" "614.9" "415.5" "" "" "" "" "" "" "" "" "" "" "426.4" "311.6" "335.3" "334.9" "289.5" "326.1" "329.8" "280.9" "333.6" "415.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8527092773428768711" "False" "High" "IsMasterProtein" "Q13561" "Dynactin subunit 2 OS=Homo sapiens OX=9606 GN=DCTN2 PE=1 SV=4" "0.000" "False" "33.246" "22" "9" "10" "9" "401" "44.2" "5.21" "30.45" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04912" "10540" "ENSG00000175203" "DCTN2" "B2RBK5; hsa:10540; Q13561; Q86YN2; Q9BW17" "Vasopressin-regulated water reabsorption" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "12" "0" "0.989" "1.204" "1.160" "1.159" "0.900" "1.045" "0.842" "1.064" "2.289" "236.4" "233.7" "284.6" "274.3" "274.0" "212.6" "246.9" "199.0" "251.5" "541.1" "" "" "" "" "" "" "" "" "" "" "141.4" "121.4" "157.6" "128.8" "127.0" "108.9" "114.8" "89.3" "136.4" "541.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-91982353768306611" "False" "High" "IsMasterProtein" "P00492" "Hypoxanthine-guanine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=HPRT1 PE=1 SV=2" "0.000" "False" "33.217" "35" "7" "38" "7" "218" "24.6" "6.68" "86.45" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00156" "3251" "ENSG00000165704" "HPRT1" "A6NHF0; B2R8M9; hsa:3251; P00492" "Mesodermal commitment pathway" "Azathioprine ADME; Purine salvage; Defective HPRT1 disrupts guanine and hypoxanthine salvage" "4" "0" "0.966" "0.970" "0.953" "0.968" "0.959" "0.982" "0.957" "0.978" "0.635" "2559.5" "2472.7" "2482.8" "2440.3" "2477.9" "2454.5" "2514.0" "2449.5" "2503.8" "1626.4" "" "" "" "" "" "" "" "" "" "" "1531.7" "1285.0" "1374.9" "1145.7" "1148.5" "1256.5" "1169.0" "1099.7" "1358.4" "1626.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8048199414682788645" "False" "High" "IsMasterProtein" "Q06323" "Proteasome activator complex subunit 1 OS=Homo sapiens OX=9606 GN=PSME1 PE=1 SV=1" "0.000" "False" "33.064" "32" "8" "24" "8" "249" "28.7" "6.02" "64.43" "8" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf02251, Pf02252" "5720" "ENSG00000092010; ENSG00000284916" "PSME1" "A6NJG9; H0YNE3; hsa:5720; Q06323; Q6IBM2; Q9UEF4" "Proteasome degradation" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "60" "0" "1.078" "0.902" "0.904" "1.101" "0.979" "1.202" "1.150" "1.154" "0.918" "1357.4" "1463.9" "1223.8" "1227.4" "1494.9" "1329.2" "1632.2" "1560.9" "1566.6" "1245.5" "" "" "" "" "" "" "" "" "" "" "812.3" "760.7" "677.7" "576.2" "692.9" "680.4" "758.9" "700.8" "850.0" "1245.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5469246297971201094" "False" "High" "IsMasterProtein" "Q86TU7" "Actin-histidine N-methyltransferase OS=Homo sapiens OX=9606 GN=SETD3 PE=1 SV=1" "0.000" "False" "32.956" "15" "8" "11" "8" "594" "67.2" "5.96" "32.28" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00856, Pf09273" "84193" "ENSG00000183576" "SETD3" "A0PJU3; A5PLP0; B4DZE8; hsa:84193; Q0VAQ2; Q659C0; Q86TU7; Q86TU8; Q96GY9; Q9H5U5" "Histone modifications" "PKMTs methylate histone lysines" "2" "0" "1.029" "1.022" "1.114" "1.026" "1.034" "1.050" "1.170" "1.080" "0.751" "260.2" "267.7" "265.8" "289.8" "266.9" "268.9" "273.3" "304.3" "280.9" "195.4" "" "" "" "" "" "" "" "" "" "" "155.7" "139.1" "147.2" "136.1" "123.7" "137.7" "127.1" "136.6" "152.4" "195.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5588804604694799714" "False" "High" "IsMasterProtein" "P36957" "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLST PE=1 SV=4" "0.000" "False" "32.928" "18" "9" "26" "9" "453" "48.7" "8.95" "71.07" "9" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00198, Pf00364" "1743" "ENSG00000119689" "DLST" "B7Z5W8; E7ESY5; hsa:1743; P36957; Q7LDY7; Q9BQ32" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Metabolic reprogramming in colon cancer; 7q11.23 copy number variation syndrome; 1p36 copy number variation syndrome; 10q11.21q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Lysine catabolism; Glyoxylate metabolism and glycine degradation" "10" "0" "1.008" "0.936" "1.009" "1.051" "0.853" "1.197" "0.961" "1.071" "0.622" "2700.4" "2722.5" "2528.0" "2725.5" "2839.2" "2304.7" "3232.5" "2594.9" "2891.6" "1680.2" "" "" "" "" "" "" "" "" "" "" "1616.1" "1414.8" "1399.9" "1279.5" "1316.0" "1179.8" "1503.0" "1165.0" "1568.8" "1680.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5457086219515973345" "False" "High" "IsMasterProtein" "P61086" "Ubiquitin-conjugating enzyme E2 K OS=Homo sapiens OX=9606 GN=UBE2K PE=1 SV=3" "0.000" "False" "32.860" "25" "5" "24" "5" "200" "22.4" "5.44" "61.82" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179, Pf00627" "3093" "ENSG00000078140" "UBE2K" "A6NJC1; A8K5Y9; B2RDF8; C9JGP1; hsa:3093; O54806; P27924; P61086; Q16721; Q9CVV9; Q9Y2D3" "" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Negative regulators of DDX58/IFIH1 signaling" "3" "0" "1.070" "0.973" "1.087" "1.027" "1.031" "1.110" "1.093" "1.074" "0.848" "1047.2" "1120.9" "1018.4" "1138.6" "1076.0" "1079.8" "1162.1" "1144.3" "1124.4" "888.0" "" "" "" "" "" "" "" "" "" "" "626.7" "582.5" "564.0" "534.5" "498.7" "552.8" "540.4" "513.7" "610.0" "888.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2770447616449315305" "False" "High" "IsMasterProtein" "Q9Y678" "Coatomer subunit gamma-1 OS=Homo sapiens OX=9606 GN=COPG1 PE=1 SV=1" "0.000" "False" "32.831" "13" "12" "13" "11" "874" "97.7" "5.47" "27.06" "12" "transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf01602, Pf08752, Pf16381" "22820" "ENSG00000181789" "COPG1" "A8K6M8; B3KMF6; hsa:22820; Q54AC4; Q9Y678" "VEGFA-VEGFR2 signaling" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "3" "1" "0.939" "0.985" "0.944" "0.981" "1.135" "0.908" "0.925" "0.966" "1.641" "632.9" "594.3" "623.2" "597.4" "620.6" "718.2" "574.9" "585.7" "611.6" "1038.6" "" "" "" "" "" "" "" "" "" "" "378.8" "308.8" "345.1" "280.5" "287.7" "367.6" "267.3" "262.9" "331.8" "1038.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9201428938326541883" "False" "High" "IsMasterProtein" "Q15291" "Retinoblastoma-binding protein 5 OS=Homo sapiens OX=9606 GN=RBBP5 PE=1 SV=2" "0.000" "False" "32.820" "15" "8" "12" "8" "538" "59.1" "5.10" "32.74" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00400" "5929" "ENSG00000117222" "RBBP5" "A8K272; hsa:5929; Q15291; Q7Z6D8; Q8NDZ7" "Kleefstra syndrome" "Neddylation; Formation of WDR5-containing histone-modifying complexes; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "8" "0" "1.001" "0.965" "0.977" "0.987" "1.000" "1.003" "0.999" "1.011" "0.736" "853.1" "854.0" "823.3" "833.2" "842.3" "852.8" "855.8" "851.8" "862.5" "628.1" "" "" "" "" "" "" "" "" "" "" "510.5" "443.8" "455.9" "391.2" "390.4" "436.6" "397.9" "382.4" "468.0" "628.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8736083768290238180" "False" "High" "IsMasterProtein" "Cont_P13647" "Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3" "0.000" "True" "32.809" "15" "10" "14" "6" "590" "62.3" "7.74" "34.18" "10" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;cytoskeletal activity;other molecular function" "Pf00038, Pf16208" "3852" "ENSG00000186081" "KRT5" "hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91" "" "Formation of the cornified envelope; Type I hemidesmosome assembly" "3" "0" "0.554" "4.736" "0.606" "0.536" "0.885" "0.633" "0.558" "0.945" "1.232" "206.6" "114.5" "978.5" "125.2" "110.8" "182.8" "130.8" "115.4" "195.2" "254.5" "" "" "" "" "" "" "" "" "" "" "123.7" "59.5" "541.9" "58.8" "51.4" "93.6" "60.8" "51.8" "105.9" "254.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6708028902102911891" "False" "High" "IsMasterProtein" "P21281" "V-type proton ATPase subunit B, brain isoform OS=Homo sapiens OX=9606 GN=ATP6V1B2 PE=1 SV=3" "0.000" "False" "32.727" "17" "8" "19" "8" "511" "56.5" "5.81" "41.15" "8" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00006, Pf02874" "526" "ENSG00000147416" "ATP6V1B2" "B2R5Z3; D3DSQ5; hsa:526; P21281; Q14544; Q15859; Q96IR0" "" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "5" "0" "1.089" "1.063" "1.076" "1.024" "1.037" "1.070" "0.958" "0.957" "1.189" "896.7" "976.4" "953.5" "965.1" "918.6" "929.8" "959.6" "858.9" "858.4" "1066.0" "" "" "" "" "" "" "" "" "" "" "536.6" "507.4" "528.1" "453.1" "425.8" "476.0" "446.2" "385.6" "465.7" "1066.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6625268949045148761" "False" "High" "IsMasterProtein" "Q8N163" "Cell cycle and apoptosis regulator protein 2 OS=Homo sapiens OX=9606 GN=CCAR2 PE=1 SV=2" "0.000" "False" "32.700" "11" "10" "12" "10" "923" "102.8" "5.22" "33.86" "10" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf14443, Pf14444, Pf19256, Pf19257" "57805" "ENSG00000158941" "CCAR2" "A6NL03; B2RB79; D3DSR6; hsa:57805; Q6P0Q9; Q8N163; Q8N3G7; Q8N8M1; Q8TF34; Q9H9Q9; Q9HD12; Q9NT55" "TAR syndrome" "Regulation of HSF1-mediated heat shock response" "2" "0" "1.053" "1.296" "1.193" "1.187" "1.151" "1.118" "0.390" "1.346" "11.278" "268.2" "282.5" "347.7" "320.0" "318.3" "308.8" "299.8" "104.6" "361.0" "3025.1" "" "" "" "" "" "" "" "" "" "" "160.5" "146.8" "192.6" "150.2" "147.6" "158.1" "139.4" "47.0" "195.9" "3025.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "777273144622755670" "False" "High" "IsMasterProtein" "P51649" "Succinate-semialdehyde dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH5A1 PE=1 SV=2" "0.000" "False" "32.695" "12" "7" "26" "7" "535" "57.2" "8.28" "74.03" "7" "cell-cell signaling;other metabolic processes;developmental processes" "mitochondrion;other cell component" "other molecular function" "Pf00171" "7915" "ENSG00000112294" "ALDH5A1" "B2RD26; G5E949; hsa:7915; P51649; Q546H9; Q8N3W6" "Fragile X syndrome" "Degradation of GABA" "2" "0" "0.971" "0.967" "0.955" "0.914" "0.981" "0.896" "0.985" "0.927" "0.538" "2117.9" "2057.4" "2048.6" "2022.5" "1935.3" "2077.0" "1898.0" "2086.2" "1964.3" "1138.8" "" "" "" "" "" "" "" "" "" "" "1267.4" "1069.2" "1134.5" "949.5" "897.0" "1063.3" "882.5" "936.6" "1065.7" "1138.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-327475496585371320" "False" "High" "IsMasterProtein" "Q9BWD1" "Acetyl-CoA acetyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=ACAT2 PE=1 SV=2" "0.000" "False" "32.695" "18" "7" "33" "7" "397" "41.3" "6.92" "97.76" "7" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00108, Pf02803" "39" "ENSG00000120437" "ACAT2" "B7Z233; E1P5B1; hsa:39; Q16146; Q5TCL7; Q8TDM4; Q9BWD1" "Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "Cholesterol biosynthesis" "6" "0" "0.968" "0.982" "0.950" "1.009" "0.801" "1.186" "0.898" "1.108" "0.589" "1674.5" "1620.4" "1644.6" "1591.2" "1690.3" "1340.8" "1985.8" "1503.4" "1854.6" "986.4" "" "" "" "" "" "" "" "" "" "" "1002.1" "842.1" "910.8" "747.0" "783.5" "686.4" "923.4" "675.0" "1006.2" "986.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6241342632728061571" "False" "High" "IsMasterProtein" "O43148" "mRNA cap guanine-N7 methyltransferase OS=Homo sapiens OX=9606 GN=RNMT PE=1 SV=1" "0.000" "False" "32.682" "17" "7" "14" "7" "476" "54.8" "6.61" "30.94" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03291" "8731" "ENSG00000101654" "RNMT" "B0YJ90; D3DUJ5; hsa:8731; O43148; O94996; Q9UIJ9" "mRNA processing; 15q25 copy number variation" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "5" "0" "1.009" "0.923" "1.032" "0.962" "0.963" "0.907" "1.027" "1.047" "0.542" "674.2" "680.5" "622.0" "695.6" "648.8" "649.0" "611.8" "692.3" "705.9" "365.4" "" "" "" "" "" "" "" "" "" "" "403.5" "353.7" "344.5" "326.6" "300.7" "332.2" "284.5" "310.8" "383.0" "365.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7463755477932393031" "False" "High" "IsMasterProtein" "Q9H4M9" "EH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=EHD1 PE=1 SV=2" "0.000" "False" "32.601" "17" "9" "16" "9" "534" "60.6" "6.83" "37.86" "9" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00350, Pf12763, Pf16880, Pf18150" "10938" "ENSG00000110047" "EHD1" "hsa:10938; O14611; Q2M3Q4; Q9H4M9; Q9UNR3" "Insulin signaling" "Factors involved in megakaryocyte development and platelet production" "2" "0" "0.977" "0.943" "1.147" "1.213" "1.122" "1.257" "1.156" "1.246" "1.849" "370.8" "362.2" "349.7" "425.3" "450.0" "416.1" "466.1" "428.7" "462.2" "685.5" "" "" "" "" "" "" "" "" "" "" "221.9" "188.2" "193.6" "199.7" "208.6" "213.0" "216.7" "192.5" "250.8" "685.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1348431233397446306" "False" "High" "IsMasterProtein" "P62495" "Eukaryotic peptide chain release factor subunit 1 OS=Homo sapiens OX=9606 GN=ETF1 PE=1 SV=3" "0.000" "False" "32.592" "16" "6" "26" "6" "437" "49.0" "5.71" "61.70" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf03463, Pf03464, Pf03465" "2107" "ENSG00000120705" "ETF1" "B2R6B4; D3DQC1; hsa:2107; P46055; P62495; Q5M7Z7; Q96CG1" "Translation factors" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Protein hydroxylation" "6" "0" "1.092" "1.036" "1.105" "1.056" "1.121" "1.013" "0.939" "1.095" "2.637" "435.3" "475.5" "451.0" "481.1" "459.8" "488.1" "441.2" "408.9" "476.7" "1147.7" "" "" "" "" "" "" "" "" "" "" "260.5" "247.1" "249.8" "225.9" "213.1" "249.9" "205.1" "183.6" "258.6" "1147.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2127950675318566661" "False" "High" "IsMasterProtein" "Q9UJA5" "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 OS=Homo sapiens OX=9606 GN=TRMT6 PE=1 SV=1" "0.000" "False" "32.584" "20" "10" "14" "10" "497" "55.8" "7.55" "40.45" "10" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf04189" "51605" "ENSG00000089195" "TRMT6" "B4DUV6; hsa:51605; Q76P92; Q9BQV5; Q9UJA5; Q9ULR7; Q9Y2Z8" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.043" "0.964" "1.075" "1.008" "1.013" "0.951" "1.005" "0.935" "0.692" "1156.3" "1205.6" "1115.2" "1243.5" "1165.6" "1171.7" "1099.6" "1162.7" "1080.6" "800.1" "" "" "" "" "" "" "" "" "" "" "692.0" "626.5" "617.6" "583.8" "540.3" "599.8" "511.3" "522.0" "586.3" "800.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "868363632382073498" "False" "High" "IsMasterProtein" "Q6UB35" "Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD1L PE=1 SV=1" "0.000" "False" "32.418" "8" "8" "13" "8" "978" "105.7" "8.06" "30.55" "8" "other metabolic processes;developmental processes" "cytosol;mitochondrion" "other molecular function" "Pf00763, Pf01268, Pf02882" "25902" "ENSG00000120254" "MTHFD1L" "hsa:25902; Q2TBF3; Q6UB35; Q8WVW0; Q96HG8; Q9H789; Q9UFU8" "One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways" "Metabolism of folate and pterines" "3" "0" "1.072" "1.041" "1.019" "1.047" "1.195" "0.920" "0.898" "0.995" "1.950" "394.4" "422.7" "410.4" "401.9" "413.0" "471.1" "362.7" "354.1" "392.4" "768.9" "" "" "" "" "" "" "" "" "" "" "236.0" "219.7" "227.3" "188.7" "191.5" "241.2" "168.6" "159.0" "212.9" "768.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6590851508053806454" "False" "High" "IsMasterProtein" "Q9BQ52" "Zinc phosphodiesterase ELAC protein 2 OS=Homo sapiens OX=9606 GN=ELAC2 PE=1 SV=2" "0.000" "False" "32.401" "13" "10" "19" "10" "826" "92.2" "7.90" "47.02" "10" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf12706, Pf13691" "60528" "ENSG00000006744" "ELAC2" "B4DPL9; hsa:60528; Q6IA94; Q9BQ52; Q9HAS8; Q9HAS9; Q9NVT1" "" "tRNA processing in the nucleus; tRNA processing in the mitochondrion; rRNA processing in the mitochondrion; tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis" "4" "0" "0.874" "0.902" "1.014" "1.020" "1.007" "0.885" "0.987" "0.848" "0.744" "524.2" "457.9" "473.0" "531.5" "534.4" "527.7" "463.9" "517.1" "444.4" "389.8" "" "" "" "" "" "" "" "" "" "" "313.7" "237.9" "262.0" "249.5" "247.7" "270.1" "215.7" "232.2" "241.1" "389.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2874885037648560876" "False" "High" "IsMasterProtein" "O60869" "Endothelial differentiation-related factor 1 OS=Homo sapiens OX=9606 GN=EDF1 PE=1 SV=1" "0.000" "False" "32.399" "51" "9" "33" "9" "148" "16.4" "9.95" "95.62" "9" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01381, Pf08523" "8721" "ENSG00000107223" "EDF1" "hsa:8721; O60869; Q5T5T2; Q9UIM1" "" "" "0" "0" "0.988" "0.959" "0.943" "0.998" "0.945" "0.966" "1.021" "0.899" "0.487" "3637.7" "3594.7" "3488.0" "3428.6" "3629.9" "3438.7" "3515.7" "3713.9" "3269.1" "1770.2" "" "" "" "" "" "" "" "" "" "" "2177.0" "1868.0" "1931.6" "1609.6" "1682.5" "1760.3" "1634.7" "1667.3" "1773.6" "1770.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6634047056467408227" "False" "High" "IsMasterProtein" "P62318" "Small nuclear ribonucleoprotein Sm D3 OS=Homo sapiens OX=9606 GN=SNRPD3 PE=1 SV=1" "0.000" "False" "32.361" "52" "5" "14" "5" "126" "13.9" "10.32" "36.79" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "6634" "ENSG00000100028" "SNRPD3" "B4DJP7; B5BU13; hsa:6634; P43331; P62318" "mRNA processing" "SARS-CoV-2 modulates host translation machinery; snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "0.985" "1.049" "0.983" "1.062" "1.096" "0.985" "1.021" "1.025" "0.556" "638.2" "628.8" "669.4" "627.1" "677.9" "699.6" "628.5" "651.5" "654.1" "354.6" "" "" "" "" "" "" "" "" "" "" "381.9" "326.7" "370.7" "294.4" "314.2" "358.2" "292.2" "292.5" "354.9" "354.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5100342078982033337" "False" "High" "IsMasterProtein" "Q8N684" "Cleavage and polyadenylation specificity factor subunit 7 OS=Homo sapiens OX=9606 GN=CPSF7 PE=1 SV=1" "0.000" "False" "32.344" "23" "10" "16" "10" "471" "52.0" "8.00" "40.17" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "79869" "ENSG00000149532" "CPSF7" "B3KU04; C9K0Q4; hsa:79869; Q7Z3H9; Q8N684; Q9H025; Q9H9V1" "" "RHOBTB1 GTPase cycle; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.065" "1.071" "1.043" "1.086" "1.026" "1.054" "1.058" "1.027" "0.893" "381.3" "406.2" "408.3" "397.8" "414.1" "391.0" "402.1" "403.4" "391.6" "340.5" "" "" "" "" "" "" "" "" "" "" "228.2" "211.1" "226.1" "186.8" "191.9" "200.2" "187.0" "181.1" "212.5" "340.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9162404171034655345" "False" "High" "IsMasterProtein" "Q9Y223" "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase OS=Homo sapiens OX=9606 GN=GNE PE=1 SV=1" "0.000" "False" "32.314" "14" "8" "10" "8" "722" "79.2" "6.80" "26.37" "8" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf00480, Pf02350" "10020" "ENSG00000159921" "GNE" "A6PZH2; A6PZH3; A7UNU7; B2R6E1; B7Z372; B7Z428; D3DRP7; F5H499; H0YFA7; hsa:10020; Q0VA94; Q9Y223" "Sialylation" "Sialic acid metabolism; Defective GNE causes sialuria, NK and IBM2" "3" "0" "0.999" "1.018" "0.984" "1.050" "1.172" "1.218" "1.223" "1.083" "0.779" "94.2" "94.2" "96.0" "92.7" "99.0" "110.4" "114.8" "115.3" "102.0" "73.4" "" "" "" "" "" "" "" "" "" "" "56.4" "48.9" "53.1" "43.5" "45.9" "56.5" "53.4" "51.7" "55.3" "73.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3895528791649615838" "False" "High" "IsMasterProtein" "Q86UE4" "Protein LYRIC OS=Homo sapiens OX=9606 GN=MTDH PE=1 SV=2" "0.000" "False" "32.232" "14" "8" "11" "8" "582" "63.8" "9.32" "32.83" "8" "signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15686" "92140" "ENSG00000147649" "MTDH" "hsa:92140; Q05DH2; Q52QU9; Q6PK07; Q86UE4; Q8TCX3" "Gastric cancer network 2; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; CCL18 signaling pathway" "" "3" "0" "1.025" "0.877" "0.909" "1.084" "1.037" "1.088" "1.104" "0.932" "0.387" "500.9" "513.3" "439.3" "455.4" "543.1" "519.6" "545.1" "553.0" "466.6" "194.0" "" "" "" "" "" "" "" "" "" "" "299.7" "266.8" "243.3" "213.8" "251.7" "266.0" "253.5" "248.3" "253.2" "194.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2986049448252169894" "False" "High" "IsMasterProtein" "Q8N3U4" "Cohesin subunit SA-2 OS=Homo sapiens OX=9606 GN=STAG2 PE=1 SV=3" "0.000" "False" "32.170" "8" "12" "21" "9" "1231" "141.2" "5.43" "45.73" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08514, Pf21581" "10735" "ENSG00000101972" "STAG2" "B1AMT5; D3DTF5; hsa:10735; O00540; Q5JTI6; Q68DE9; Q8N3U4; Q9H1N8" "Cell cycle; Cohesin complex - Cornelia de Lange syndrome" "Resolution of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins; Separation of Sister Chromatids; Meiotic synapsis; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "9" "2" "1.017" "1.011" "1.018" "1.074" "1.087" "1.050" "1.035" "1.017" "1.280" "1322.7" "1345.1" "1337.2" "1346.0" "1420.0" "1438.1" "1389.3" "1369.1" "1344.8" "1693.4" "" "" "" "" "" "" "" "" "" "" "791.6" "699.0" "740.5" "631.9" "658.2" "736.2" "646.0" "614.6" "729.6" "1693.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6072286448447602827" "False" "High" "IsMasterProtein" "Q9UBE0" "SUMO-activating enzyme subunit 1 OS=Homo sapiens OX=9606 GN=SAE1 PE=1 SV=1" "0.000" "False" "32.048" "19" "8" "23" "8" "346" "38.4" "5.30" "60.68" "8" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00899" "10055" "ENSG00000142230" "SAE1" "B2RDP5; B3KMQ2; F5GXX7; G3XAK6; hsa:10055; O95717; Q9P020; Q9UBE0" "" "SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "2" "0" "1.111" "1.186" "1.165" "1.078" "1.073" "1.053" "1.020" "1.069" "1.566" "1293.8" "1437.4" "1534.1" "1507.3" "1394.7" "1388.3" "1362.0" "1319.5" "1382.8" "2025.6" "" "" "" "" "" "" "" "" "" "" "774.3" "747.0" "849.6" "707.6" "646.5" "710.7" "633.3" "592.4" "750.2" "2025.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6222929657638767461" "False" "High" "IsMasterProtein" "P23284" "Peptidyl-prolyl cis-trans isomerase B OS=Homo sapiens OX=9606 GN=PPIB PE=1 SV=2" "0.000" "False" "32.048" "32" "7" "16" "7" "216" "23.7" "9.41" "46.66" "7" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00160" "5479" "ENSG00000166794" "PPIB" "A8K534; hsa:5479; P23284; Q6IBH5; Q9BVK5" "Prolactin signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta" "Collagen biosynthesis and modifying enzymes; SARS-CoV-1 activates/modulates innate immune responses" "4" "0" "0.953" "1.017" "1.020" "1.006" "1.054" "1.009" "0.766" "1.014" "3.071" "1014.0" "966.4" "1030.8" "1034.0" "1020.0" "1068.5" "1023.4" "776.3" "1027.9" "3113.6" "" "" "" "" "" "" "" "" "" "" "606.8" "502.2" "570.8" "485.4" "472.8" "547.0" "475.8" "348.5" "557.7" "3113.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1038572201038202760" "False" "High" "IsMasterProtein" "P05114" "Non-histone chromosomal protein HMG-14 OS=Homo sapiens OX=9606 GN=HMGN1 PE=1 SV=3" "0.000" "False" "31.988" "43" "4" "35" "4" "100" "10.7" "9.60" "93.88" "4" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "3150" "ENSG00000205581" "HMGN1" "hsa:3150; P05114; Q3KQR8" "ATM signaling in development and disease ; p38 MAPK signaling pathway; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "8" "0" "0.985" "0.967" "0.936" "0.968" "0.922" "1.028" "1.067" "0.890" "0.363" "2308.7" "2273.9" "2233.0" "2159.9" "2234.5" "2128.8" "2373.8" "2463.1" "2055.5" "838.1" "" "" "" "" "" "" "" "" "" "" "1381.6" "1181.7" "1236.6" "1014.0" "1035.7" "1089.8" "1103.8" "1105.8" "1115.2" "838.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8008274239603490952" "False" "High" "IsMasterProtein" "P51991" "Heterogeneous nuclear ribonucleoprotein A3 OS=Homo sapiens OX=9606 GN=HNRNPA3 PE=1 SV=2" "0.000" "False" "31.968" "26" "8" "46" "6" "378" "39.6" "9.01" "111.76" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "220988" "ENSG00000170144" "HNRNPA3" "D3DPF4; hsa:220988; P51991; Q53RW7; Q6URK5" "" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "2" "0" "1.052" "1.105" "1.121" "1.094" "1.050" "1.071" "0.794" "1.066" "3.438" "368.3" "387.3" "406.8" "412.7" "402.7" "386.8" "394.5" "292.4" "392.6" "1266.3" "" "" "" "" "" "" "" "" "" "" "220.4" "201.3" "225.3" "193.8" "186.7" "198.0" "183.4" "131.3" "213.0" "1266.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8496601930648358283" "False" "High" "IsMasterProtein" "Q5T6F2" "Ubiquitin-associated protein 2 OS=Homo sapiens OX=9606 GN=UBAP2 PE=1 SV=1" "0.000" "False" "31.961" "7" "8" "15" "8" "1119" "117.0" "7.34" "38.18" "8" "other biological processes" "nucleus;other cell component" "" "Pf12478" "55833" "ENSG00000137073" "UBAP2" "hsa:55833; Q2M2R4; Q5JV03; Q5T6F2; Q6PK34; Q8NC94; Q9P237" "" "" "0" "0" "1.047" "0.957" "0.976" "0.972" "1.002" "1.063" "1.123" "0.978" "0.573" "865.7" "906.0" "828.8" "845.2" "841.9" "867.1" "920.3" "972.5" "846.5" "496.2" "" "" "" "" "" "" "" "" "" "" "518.1" "470.8" "459.0" "396.8" "390.2" "443.9" "427.9" "436.6" "459.3" "496.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3853404113387134869" "False" "High" "IsMasterProtein" "Q9UK59" "Lariat debranching enzyme OS=Homo sapiens OX=9606 GN=DBR1 PE=1 SV=2" "0.000" "False" "31.958" "18" "9" "16" "9" "544" "61.5" "5.47" "25.44" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00149, Pf05011" "51163" "ENSG00000138231" "DBR1" "hsa:51163; Q96GH0; Q9NXQ6; Q9UK59" "" "" "0" "0" "1.035" "1.056" "1.054" "1.254" "1.046" "1.090" "1.048" "1.196" "0.744" "253.6" "262.5" "267.8" "267.2" "318.0" "265.3" "276.5" "265.6" "303.4" "188.6" "" "" "" "" "" "" "" "" "" "" "151.8" "136.4" "148.3" "125.4" "147.4" "135.8" "128.6" "119.3" "164.6" "188.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4686891910023409545" "False" "High" "IsMasterProtein" "P62140" "Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CB PE=1 SV=3" "0.000" "False" "31.897" "26" "7" "19" "1" "327" "37.2" "6.19" "37.30" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5500" "ENSG00000213639" "PPP1CB" "B2R5V4; D6W565; hsa:5500; P37140; P62140; Q5U087; Q6FG45" "Common pathways underlying drug addiction; Focal adhesion; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Airway smooth muscle cell contraction; Neuroinflammation and glutamatergic signaling; G13 signaling pathway" "Circadian Clock; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; Triglyceride catabolism; Regulation of PLK1 Activity at G2/M Transition; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; RHO GTPases activate PAKs; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins" "19" "0" "1.002" "1.134" "1.123" "1.075" "1.131" "1.284" "1.028" "1.264" "1.148" "77.9" "78.1" "88.4" "87.5" "83.8" "88.2" "100.1" "80.1" "98.6" "89.5" "" "" "" "" "" "" "" "" "" "" "46.6" "40.6" "48.9" "41.1" "38.8" "45.1" "46.5" "36.0" "53.5" "89.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8471595991882746273" "False" "High" "IsMasterProtein" "P35612" "Beta-adducin OS=Homo sapiens OX=9606 GN=ADD2 PE=1 SV=3" "0.000" "False" "31.894" "11" "7" "11" "7" "726" "80.8" "5.92" "26.19" "7" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "119" "ENSG00000075340" "ADD2" "A8K4P2; B4DM17; D6W5G7; D6W5G8; hsa:119; P35612; Q13482; Q16412; Q59G82; Q5U5P4; Q6P0P2; Q6PGQ4; Q7Z688; Q7Z689; Q7Z690; Q7Z691" "" "Miscellaneous transport and binding events" "1" "0" "1.010" "0.944" "1.048" "0.893" "0.902" "0.972" "0.892" "0.889" "0.738" "290.2" "293.1" "273.8" "304.0" "259.1" "261.6" "282.1" "258.8" "257.8" "214.2" "" "" "" "" "" "" "" "" "" "" "173.6" "152.3" "151.6" "142.7" "120.1" "133.9" "131.2" "116.2" "139.9" "214.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9167307694424558965" "False" "High" "IsMasterProtein" "O95336" "6-phosphogluconolactonase OS=Homo sapiens OX=9606 GN=PGLS PE=1 SV=2" "0.000" "False" "31.893" "26" "6" "37" "6" "258" "27.5" "6.05" "97.03" "6" "other metabolic processes" "cytosol" "other molecular function" "Pf01182" "25796" "ENSG00000130313" "PGLS" "hsa:25796; O95336" "Pentose phosphate metabolism" "Pentose phosphate pathway" "2" "0" "0.948" "0.932" "0.999" "0.888" "0.939" "0.946" "0.980" "0.955" "0.686" "1546.3" "1465.6" "1440.8" "1544.3" "1372.9" "1452.6" "1462.7" "1516.0" "1477.4" "1060.4" "" "" "" "" "" "" "" "" "" "" "925.4" "761.6" "797.9" "725.0" "636.3" "743.6" "680.1" "680.6" "801.5" "1060.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3650651295291502810" "False" "High" "IsMasterProtein" "O75369" "Filamin-B OS=Homo sapiens OX=9606 GN=FLNB PE=1 SV=2" "0.000" "False" "31.834" "4" "11" "13" "10" "2602" "278.0" "5.73" "30.53" "11" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00630" "2317" "ENSG00000136068" "FLNB" "B2ZZ83; B2ZZ84; B2ZZ85; C9JKE6; C9JMC4; hsa:2317; O75369; Q13706; Q59EC2; Q60FE7; Q6MZJ1; Q8WXS9; Q8WXT0; Q8WXT1; Q8WXT2; Q8WXT3; Q9NRB5; Q9NT26; Q9UEV9" "Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Ebola virus infection in host; NPHP1 deletion syndrome" "ISG15 antiviral mechanism" "6" "0" "1.142" "1.111" "1.118" "1.028" "1.037" "1.141" "1.094" "1.152" "1.330" "379.8" "433.7" "421.8" "424.6" "390.3" "393.8" "433.2" "415.3" "437.3" "505.2" "" "" "" "" "" "" "" "" "" "" "227.3" "225.4" "233.6" "199.3" "180.9" "201.6" "201.4" "186.5" "237.3" "505.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7415542887713691593" "False" "High" "IsMasterProtein" "Q01469" "Fatty acid-binding protein 5 OS=Homo sapiens OX=9606 GN=FABP5 PE=1 SV=3" "0.000" "False" "31.821" "33" "5" "68" "5" "135" "15.2" "7.01" "171.47" "5" "other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00061" "2171" "ENSG00000164687" "FABP5" "B2R4K0; hsa:2171; Q01469" "PPAR signaling pathway; Fatty acid transporters" "Neutrophil degranulation; Triglyceride catabolism; Signaling by Retinoic Acid" "5" "0" "1.038" "1.021" "1.051" "1.028" "1.055" "1.053" "1.059" "0.984" "0.917" "3495.3" "3627.3" "3568.2" "3673.6" "3593.0" "3688.7" "3681.9" "3700.4" "3439.9" "3204.3" "" "" "" "" "" "" "" "" "" "" "2091.8" "1885.0" "1976.0" "1724.6" "1665.4" "1888.4" "1712.0" "1661.3" "1866.3" "3204.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7462391840116260305" "False" "High" "IsMasterProtein" "Q05086" "Ubiquitin-protein ligase E3A OS=Homo sapiens OX=9606 GN=UBE3A PE=1 SV=4" "0.000" "False" "31.758" "12" "9" "11" "9" "875" "100.6" "5.22" "28.20" "9" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00632, Pf16558" "7337" "ENSG00000114062" "UBE3A" "A8K8Z9; hsa:7337; P78355; Q05086; Q93066; Q9UEP4; Q9UEP5; Q9UEP6; Q9UEP7; Q9UEP8; Q9UEP9" "Androgen receptor signaling pathway; MECP2 and associated Rett syndrome; Prader-Willi and Angelman syndrome; Synaptic signaling pathways associated with autism spectrum disorder" "Antigen processing: Ubiquitination & Proteasome degradation" "5" "0" "1.276" "1.236" "1.203" "1.271" "1.190" "1.157" "1.100" "1.121" "1.658" "269.4" "343.8" "333.0" "323.9" "342.5" "320.7" "311.7" "296.4" "302.0" "446.5" "" "" "" "" "" "" "" "" "" "" "161.2" "178.6" "184.4" "152.1" "158.7" "164.1" "144.9" "133.1" "163.9" "446.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9007113237130658680" "False" "High" "IsMasterProtein" "O15498" "Synaptobrevin homolog YKT6 OS=Homo sapiens OX=9606 GN=YKT6 PE=1 SV=1" "0.000" "False" "31.753" "35" "7" "17" "7" "198" "22.4" "6.92" "50.76" "7" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957, Pf13774" "10652" "ENSG00000106636" "YKT6" "B4DR94; hsa:10652; O15498; Q53F01; Q6FGU9; Q6IB15" "" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; COPI-mediated anterograde transport; RAC3 GTPase cycle; Intra-Golgi traffic; COPII-mediated vesicle transport" "8" "0" "1.008" "0.844" "1.033" "1.112" "1.037" "1.171" "1.186" "0.928" "0.815" "630.3" "635.6" "531.9" "651.1" "700.9" "653.8" "738.4" "747.6" "585.0" "513.5" "" "" "" "" "" "" "" "" "" "" "377.2" "330.3" "294.6" "305.7" "324.9" "334.7" "343.3" "335.6" "317.4" "513.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6087199310060456450" "False" "High" "IsMasterProtein" "Q9UI30" "Multifunctional methyltransferase subunit TRM112-like protein OS=Homo sapiens OX=9606 GN=TRMT112 PE=1 SV=1" "0.000" "False" "31.711" "48" "5" "16" "5" "125" "14.2" "5.26" "49.75" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03966" "51504" "ENSG00000173113" "TRMT112" "B2R539; hsa:51504; J3KNG5; Q3MHC7; Q8N2Z4; Q9UI30" "" "Eukaryotic Translation Termination; rRNA modification in the nucleus and cytosol; tRNA modification in the nucleus and cytosol; Methylation" "4" "0" "0.981" "0.947" "0.966" "1.018" "0.927" "1.020" "0.918" "0.971" "0.871" "782.0" "766.9" "740.6" "755.4" "796.3" "724.9" "797.8" "717.7" "759.2" "680.9" "" "" "" "" "" "" "" "" "" "" "468.0" "398.5" "410.1" "354.7" "369.1" "371.1" "371.0" "322.2" "411.9" "680.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1964393919908826502" "False" "High" "IsMasterProtein" "Q96I99" "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG2 PE=1 SV=2" "0.000" "False" "31.692" "15" "6" "10" "6" "432" "46.5" "6.39" "29.87" "6" "other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf00549, Pf08442" "8801" "ENSG00000172340" "SUCLG2" "C9JVT2; hsa:8801; O95195; Q6NUH7; Q86VX8; Q8WUQ1; Q96I99" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Metabolic reprogramming in colon cancer; TCA cycle (aka Krebs or citric acid cycle)" "Mitochondrial protein degradation; Citric acid cycle (TCA cycle)" "5" "0" "1.041" "0.941" "1.056" "1.078" "0.940" "1.060" "1.199" "0.981" "1.466" "296.4" "308.6" "278.9" "313.0" "319.5" "278.7" "314.1" "355.3" "290.8" "434.6" "" "" "" "" "" "" "" "" "" "" "177.4" "160.4" "154.5" "147.0" "148.1" "142.7" "146.0" "159.5" "157.8" "434.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3931502688338012469" "False" "High" "IsMasterProtein" "P35249" "Replication factor C subunit 4 OS=Homo sapiens OX=9606 GN=RFC4 PE=1 SV=2" "0.000" "False" "31.680" "29" "10" "16" "10" "363" "39.7" "8.02" "33.60" "10" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5984" "ENSG00000163918" "RFC4" "B4DM41; D3DNV2; hsa:5984; P35249; Q6FHX7" "Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "28" "0" "0.950" "0.948" "1.061" "1.145" "1.129" "1.162" "1.004" "1.185" "2.473" "553.4" "525.9" "524.6" "587.3" "633.4" "625.0" "643.1" "555.9" "655.8" "1368.6" "" "" "" "" "" "" "" "" "" "" "331.2" "273.3" "290.5" "275.7" "293.6" "319.9" "299.0" "249.6" "355.8" "1368.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4758086446517534587" "False" "High" "IsMasterProtein" "P62316" "Small nuclear ribonucleoprotein Sm D2 OS=Homo sapiens OX=9606 GN=SNRPD2 PE=1 SV=1" "0.000" "False" "31.661" "62" "7" "39" "7" "118" "13.5" "9.91" "98.58" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6633" "ENSG00000125743" "SNRPD2" "A8K797; hsa:6633; J3KPM5; P43330; P62316" "mRNA processing" "snRNP Assembly; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway" "5" "0" "0.974" "0.953" "0.917" "0.983" "0.991" "0.972" "1.036" "0.967" "0.457" "2942.4" "2866.3" "2803.2" "2698.7" "2891.9" "2915.3" "2860.4" "3049.3" "2846.2" "1344.3" "" "" "" "" "" "" "" "" "" "" "1760.9" "1489.5" "1552.4" "1267.0" "1340.5" "1492.4" "1330.0" "1368.9" "1544.2" "1344.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6692075332981007833" "False" "High" "IsMasterProtein" "Q13451" "Peptidyl-prolyl cis-trans isomerase FKBP5 OS=Homo sapiens OX=9606 GN=FKBP5 PE=1 SV=2" "0.000" "False" "31.592" "25" "9" "11" "9" "457" "51.2" "5.90" "26.82" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00254, Pf00515" "2289" "ENSG00000096060" "FKBP5" "F5H7R1; hsa:2289; Q13451; Q59EB8; Q5TGM6" "Androgen receptor network in prostate cancer; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; MECP2 and associated Rett syndrome" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; ESR-mediated signaling; MECP2 regulates neuronal receptors and channels" "7" "0" "1.202" "1.429" "1.295" "1.242" "1.425" "1.440" "0.281" "1.291" "13.267" "147.0" "176.7" "210.1" "190.4" "182.6" "209.6" "211.7" "41.3" "189.8" "1950.8" "" "" "" "" "" "" "" "" "" "" "88.0" "91.8" "116.3" "89.4" "84.6" "107.3" "98.5" "18.5" "103.0" "1950.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1365252663665012706" "False" "High" "IsMasterProtein" "P49589" "Cysteine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=CARS1 PE=1 SV=3" "0.000" "False" "31.554" "13" "8" "15" "8" "748" "85.4" "6.76" "40.01" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01406" "833" "ENSG00000110619; ENSG00000278191" "CARS1" "hsa:833; P49589; Q53XI8; Q5HYE4; Q9HD24; Q9HD25" "" "Signaling by ALK fusions and activated point mutants; Cytosolic tRNA aminoacylation" "2" "0" "1.228" "1.080" "1.263" "1.105" "1.028" "0.992" "1.043" "1.302" "0.923" "139.2" "170.9" "150.3" "175.8" "153.8" "143.0" "138.1" "145.2" "181.2" "128.5" "" "" "" "" "" "" "" "" "" "" "83.3" "88.8" "83.2" "82.6" "71.3" "73.2" "64.2" "65.2" "98.3" "128.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2320563030437256339" "False" "High" "IsMasterProtein" "Q5RKV6" "Exosome complex component MTR3 OS=Homo sapiens OX=9606 GN=EXOSC6 PE=1 SV=1" "0.000" "False" "31.516" "28" "6" "19" "6" "272" "28.2" "6.28" "55.73" "6" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf01138" "118460" "ENSG00000223496" "EXOSC6" "hsa:118460; Q5RKV6" "" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "1.010" "0.987" "1.041" "1.035" "1.037" "1.007" "1.015" "0.951" "0.840" "705.9" "712.9" "697.1" "734.9" "730.5" "732.1" "710.8" "716.3" "671.3" "592.6" "" "" "" "" "" "" "" "" "" "" "422.4" "370.5" "386.0" "345.0" "338.6" "374.8" "330.5" "321.6" "364.2" "592.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3232925650926593770" "False" "High" "IsMasterProtein" "Q9C0C2" "182 kDa tankyrase-1-binding protein OS=Homo sapiens OX=9606 GN=TNKS1BP1 PE=1 SV=4" "0.000" "False" "31.475" "7" "9" "9" "9" "1729" "181.7" "4.86" "24.75" "9" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15327" "85456" "ENSG00000149115" "TNKS1BP1" "A7E2F8; hsa:85456; Q6PJ35; Q6ZV74; Q9C0C2" "Ciliary landscape" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "4" "0" "1.048" "0.941" "1.038" "1.123" "0.994" "1.280" "1.168" "1.083" "0.733" "281.2" "294.8" "264.5" "292.0" "315.9" "279.6" "360.1" "328.5" "304.6" "206.0" "" "" "" "" "" "" "" "" "" "" "168.3" "153.2" "146.5" "137.1" "146.4" "143.2" "167.4" "147.5" "165.2" "206.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3098195104215073585" "False" "High" "IsMasterProtein" "P23919" "Thymidylate kinase OS=Homo sapiens OX=9606 GN=DTYMK PE=1 SV=4" "0.000" "False" "31.465" "37" "8" "24" "8" "212" "23.8" "8.27" "65.71" "8" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf02223" "1841" "ENSG00000168393" "DTYMK" "B7ZW70; hsa:1841; P23919; Q6FGX1; Q9BUX4" "Pyrimidine metabolism; 2q37 copy number variation syndrome" "Interconversion of nucleotide di- and triphosphates" "3" "0" "1.021" "1.005" "1.131" "1.006" "1.060" "1.094" "1.061" "1.006" "0.896" "970.0" "990.3" "975.3" "1097.1" "975.3" "1028.4" "1061.6" "1029.5" "975.9" "869.3" "" "" "" "" "" "" "" "" "" "" "580.5" "514.6" "540.1" "515.1" "452.1" "526.4" "493.6" "462.2" "529.5" "869.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8333902830713908614" "False" "High" "IsMasterProtein" "P05388" "Large ribosomal subunit protein uL10 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1" "0.000" "False" "31.407" "24" "7" "24" "7" "317" "34.3" "5.97" "57.19" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00428, Pf00466, Pf17777" "6175" "ENSG00000089157" "RPLP0" "hsa:6175; P05388; Q3B7A4; Q9BVK4" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.904" "0.894" "0.949" "1.001" "1.022" "0.908" "0.946" "0.950" "0.393" "911.6" "823.9" "815.3" "864.8" "912.1" "931.4" "827.3" "862.4" "866.1" "358.4" "" "" "" "" "" "" "" "" "" "" "545.5" "428.2" "451.5" "406.0" "422.8" "476.8" "384.7" "387.2" "469.9" "358.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7657012177295081485" "False" "High" "IsMasterProtein" "O43684" "Mitotic checkpoint protein BUB3 OS=Homo sapiens OX=9606 GN=BUB3 PE=1 SV=1" "0.000" "False" "31.358" "25" "8" "29" "8" "328" "37.1" "6.84" "78.94" "8" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "9184" "ENSG00000154473" "BUB3" "A6NJ42; B2R6E7; D3DRE9; hsa:9184; O43684; O43685" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "12" "0" "0.915" "0.833" "0.938" "0.966" "0.921" "0.998" "0.993" "0.979" "0.756" "1677.7" "1535.2" "1398.0" "1574.1" "1621.4" "1545.6" "1674.6" "1666.6" "1642.1" "1268.4" "" "" "" "" "" "" "" "" "" "" "1004.0" "797.8" "774.2" "739.0" "751.6" "791.2" "778.6" "748.2" "890.9" "1268.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2613471079569612470" "False" "High" "IsMasterProtein" "P14866" "Heterogeneous nuclear ribonucleoprotein L OS=Homo sapiens OX=9606 GN=HNRNPL PE=1 SV=2" "0.000" "False" "31.271" "16" "9" "27" "9" "589" "64.1" "8.22" "63.84" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "3191" "ENSG00000104824; ENSG00000282947" "HNRNPL" "A6ND69; A6NIT8; hsa:3191; P14866; Q9H3P3" "mRNA processing; Hippocampal synaptogenesis and neurogenesis" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "4" "0" "0.970" "1.065" "1.054" "1.136" "1.078" "1.047" "0.308" "1.030" "11.798" "569.1" "552.2" "606.1" "600.1" "646.3" "613.7" "595.8" "175.6" "586.1" "6714.7" "" "" "" "" "" "" "" "" "" "" "340.6" "286.9" "335.7" "281.7" "299.6" "314.2" "277.0" "78.8" "318.0" "6714.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3377056009907556172" "False" "High" "IsMasterProtein" "O14745" "Na(+)/H(+) exchange regulatory cofactor NHE-RF1 OS=Homo sapiens OX=9606 GN=NHERF1 PE=1 SV=4" "0.000" "False" "31.223" "23" "6" "13" "6" "358" "38.8" "5.77" "38.83" "6" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;transporter activity;cytoskeletal activity;other molecular function" "Pf00595, Pf09007" "9368" "ENSG00000109062" "NHERF1" "B3KY21; hsa:9368; O14745; O43552; Q86WQ5" "TAR syndrome" "" "1" "0" "1.124" "0.951" "0.895" "0.938" "0.957" "1.136" "0.990" "1.042" "0.626" "292.5" "328.8" "278.1" "261.8" "274.3" "280.0" "332.2" "289.7" "304.9" "183.3" "" "" "" "" "" "" "" "" "" "" "175.1" "170.9" "154.0" "122.9" "127.2" "143.3" "154.5" "130.1" "165.4" "183.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-885056090803738498" "False" "High" "IsMasterProtein" "P47897" "Glutamine--tRNA ligase OS=Homo sapiens OX=9606 GN=QARS1 PE=1 SV=1" "0.000" "False" "31.217" "13" "10" "15" "9" "775" "87.7" "7.15" "32.13" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf00749, Pf03950, Pf04557, Pf04558, Pf20974" "5859" "ENSG00000172053" "QARS1" "B4DWJ2; hsa:5859; P47897" "" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "3" "0" "1.051" "1.068" "1.232" "1.228" "1.183" "1.405" "0.541" "1.091" "8.153" "197.5" "207.6" "211.0" "243.3" "242.5" "233.6" "277.5" "106.8" "215.4" "1610.2" "" "" "" "" "" "" "" "" "" "" "118.2" "107.9" "116.8" "114.2" "112.4" "119.6" "129.0" "48.0" "116.9" "1610.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1839612719642205858" "False" "High" "IsMasterProtein" "P09417" "Dihydropteridine reductase OS=Homo sapiens OX=9606 GN=QDPR PE=1 SV=2" "0.000" "False" "31.166" "30" "6" "24" "6" "244" "25.8" "7.37" "75.74" "6" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00106" "5860" "ENSG00000151552" "QDPR" "A8K158; B3KW71; hsa:5860; P09417; Q53F52; Q9H3M5" "" "Phenylalanine metabolism" "1" "0" "0.854" "0.824" "0.875" "0.930" "0.906" "0.955" "0.880" "0.912" "0.702" "847.0" "723.4" "698.0" "740.7" "787.5" "767.6" "808.6" "745.3" "772.4" "594.8" "" "" "" "" "" "" "" "" "" "" "506.9" "375.9" "386.5" "347.7" "365.0" "392.9" "376.0" "334.6" "419.1" "594.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "92352165089450524" "False" "High" "IsMasterProtein" "O15355" "Protein phosphatase 1G OS=Homo sapiens OX=9606 GN=PPM1G PE=1 SV=1" "0.000" "False" "31.084" "17" "6" "8" "6" "546" "59.2" "4.36" "24.57" "6" "protein metabolism;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf00481" "5496" "ENSG00000115241" "PPM1G" "hsa:5496; O15355" "VEGFA-VEGFR2 signaling; mRNA processing" "" "2" "0" "1.144" "1.509" "1.351" "1.188" "1.096" "1.063" "0.452" "1.236" "8.663" "142.7" "163.2" "215.4" "192.8" "169.5" "156.4" "151.7" "64.5" "176.3" "1236.1" "" "" "" "" "" "" "" "" "" "" "85.4" "84.8" "119.3" "90.5" "78.6" "80.1" "70.5" "28.9" "95.7" "1236.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1037069693652576559" "False" "High" "IsMasterProtein" "P31943" "Heterogeneous nuclear ribonucleoprotein H OS=Homo sapiens OX=9606 GN=HNRNPH1 PE=1 SV=4" "0.000" "False" "31.015" "23" "8" "18" "5" "449" "49.2" "6.30" "46.61" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08080" "3187" "ENSG00000169045; ENSG00000284254" "HNRNPH1" "B3KW86; D3DWQ2; P31943; Q6IBM4" "MECP2 and associated Rett syndrome; mRNA processing; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "6" "2" "1.016" "1.102" "1.020" "1.115" "1.081" "0.980" "0.618" "1.075" "6.770" "502.1" "510.3" "553.5" "512.2" "559.6" "542.5" "492.1" "310.4" "539.8" "3399.1" "" "" "" "" "" "" "" "" "" "" "300.5" "265.2" "306.5" "240.5" "259.4" "277.7" "228.8" "139.3" "292.8" "3399.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6669951735420197648" "False" "High" "IsMasterProtein" "O00154" "Cytosolic acyl coenzyme A thioester hydrolase OS=Homo sapiens OX=9606 GN=ACOT7 PE=1 SV=3" "0.000" "False" "31.015" "20" "8" "20" "8" "380" "41.8" "8.54" "48.74" "8" "other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf03061" "11332" "ENSG00000097021" "ACOT7" "A8K0K7; A8K232; A8K6B8; A8K837; B3KQ12; hsa:11332; O00154; O43703; Q53Y78; Q5JYL2; Q5JYL3; Q5JYL4; Q5JYL5; Q5JYL6; Q5TGR4; Q9UJM9; Q9Y539; Q9Y540" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "1.004" "1.041" "1.047" "0.952" "1.009" "1.003" "1.062" "1.013" "0.653" "1128.8" "1133.2" "1174.6" "1181.8" "1074.6" "1139.1" "1132.1" "1198.5" "1143.0" "736.8" "" "" "" "" "" "" "" "" "" "" "675.5" "588.9" "650.5" "554.8" "498.1" "583.1" "526.4" "538.1" "620.1" "736.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8210818149912646419" "False" "High" "IsMasterProtein" "P11216" "Glycogen phosphorylase, brain form OS=Homo sapiens OX=9606 GN=PYGB PE=1 SV=5" "0.000" "False" "31.007" "10" "9" "16" "9" "843" "96.6" "6.86" "39.55" "9" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00343" "5834" "ENSG00000100994" "PYGB" "hsa:5834; P11216; Q96AK1; Q9NPX8" "IL-18 signaling pathway; Glycogen synthesis and degradation" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis)" "4" "0" "1.094" "1.103" "1.105" "1.176" "1.186" "1.164" "1.197" "1.229" "0.589" "395.2" "432.5" "436.0" "436.7" "464.6" "468.7" "460.2" "472.9" "485.8" "232.7" "" "" "" "" "" "" "" "" "" "" "236.5" "224.7" "241.5" "205.0" "215.4" "239.9" "214.0" "212.3" "263.6" "232.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1997849162023251854" "False" "High" "IsMasterProtein" "P63208" "S-phase kinase-associated protein 1 OS=Homo sapiens OX=9606 GN=SKP1 PE=1 SV=2" "0.000" "False" "30.965" "43" "6" "11" "6" "163" "18.6" "4.54" "30.28" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01466, Pf03931" "6500" "ENSG00000113558" "SKP1" "D3DQ97; D3DQ98; hsa:6500; P34991; P63208; Q8TAY2" "Cell cycle; TNF-alpha signaling pathway; TGF-beta signaling pathway; Breast cancer pathway; Small cell lung cancer; Notch signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Nuclear events stimulated by ALK signaling in cancer; Antigen processing: Ubiquitination & Proteasome degradation; SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Circadian Clock; Cyclin D associated events in G1; Regulation of BACH1 activity; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Iron uptake and transport; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "39" "0" "1.026" "0.956" "0.976" "1.076" "0.967" "1.040" "1.088" "1.044" "0.585" "1091.4" "1119.8" "1043.0" "1065.1" "1174.2" "1055.9" "1135.2" "1187.6" "1139.8" "638.9" "" "" "" "" "" "" "" "" "" "" "653.1" "581.9" "577.6" "500.1" "544.2" "540.5" "527.8" "533.2" "618.4" "638.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "657128700828351651" "False" "High" "IsMasterProtein" "Q16643" "Drebrin OS=Homo sapiens OX=9606 GN=DBN1 PE=1 SV=4" "0.000" "False" "30.920" "10" "5" "8" "5" "649" "71.4" "4.45" "31.36" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "1627" "ENSG00000113758" "DBN1" "A8MV58; B2RBG0; hsa:1627; Q16643; Q9UFZ5" "5q35 copy number variation" "RHOD GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; RHOH GTPase cycle" "5" "0" "1.068" "0.971" "1.057" "1.007" "0.860" "1.074" "0.861" "0.942" "1.044" "477.5" "510.0" "463.6" "504.6" "480.8" "410.6" "513.0" "411.1" "449.8" "498.5" "" "" "" "" "" "" "" "" "" "" "285.7" "265.0" "256.7" "236.9" "222.9" "210.2" "238.5" "184.6" "244.1" "498.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3607998631011874723" "False" "High" "IsMasterProtein" "Q9UBQ7" "Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens OX=9606 GN=GRHPR PE=1 SV=1" "0.000" "False" "30.799" "24" "6" "17" "6" "328" "35.6" "7.39" "51.89" "6" "other metabolic processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00389, Pf02826" "9380" "ENSG00000137106" "GRHPR" "hsa:9380; Q5T945; Q9H3E9; Q9H636; Q9UBQ7; Q9UKX1" "" "Glyoxylate metabolism and glycine degradation" "1" "0" "0.953" "0.913" "1.019" "0.988" "1.017" "0.991" "0.927" "0.899" "0.831" "1419.2" "1352.0" "1296.3" "1445.9" "1402.0" "1443.5" "1406.5" "1315.7" "1276.1" "1179.3" "" "" "" "" "" "" "" "" "" "" "849.3" "702.6" "717.8" "678.8" "649.9" "738.9" "654.0" "590.7" "692.3" "1179.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5314781854584049203" "False" "High" "IsMasterProtein" "O75436" "Vacuolar protein sorting-associated protein 26A OS=Homo sapiens OX=9606 GN=VPS26A PE=1 SV=2" "0.000" "False" "30.763" "24" "7" "27" "7" "327" "38.1" "6.57" "46.82" "7" "transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf03643" "9559" "ENSG00000122958" "VPS26A" "A8MZ56; B2RDD3; hsa:9559; O75436; Q8TBH4; Q9H982" "" "WNT ligand biogenesis and trafficking" "1" "0" "0.970" "1.037" "0.968" "0.994" "0.980" "0.981" "0.995" "0.906" "0.815" "498.5" "483.5" "517.1" "482.6" "495.5" "488.6" "489.1" "496.0" "451.7" "406.3" "" "" "" "" "" "" "" "" "" "" "298.3" "251.3" "286.4" "226.6" "229.7" "250.1" "227.4" "222.7" "245.1" "406.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9034564449228548140" "False" "High" "IsMasterProtein" "O75223" "Gamma-glutamylcyclotransferase OS=Homo sapiens OX=9606 GN=GGCT PE=1 SV=1" "0.000" "False" "30.756" "28" "5" "14" "5" "188" "21.0" "5.14" "42.48" "5" "cell organization and biogenesis;signal transduction" "cytosol" "other molecular function" "Pf13772" "79017" "ENSG00000006625" "GGCT" "B2RDN0; B8ZZN4; B8ZZR8; hsa:79017; O75223; Q9BS37" "" "Glutathione synthesis and recycling" "1" "0" "1.073" "1.045" "0.989" "1.040" "0.994" "1.140" "1.031" "1.096" "0.614" "1673.9" "1795.8" "1749.5" "1655.1" "1740.6" "1664.1" "1908.7" "1725.2" "1834.2" "1028.6" "" "" "" "" "" "" "" "" "" "" "1001.7" "933.2" "968.9" "777.0" "806.8" "851.9" "887.5" "774.5" "995.1" "1028.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8952953409399985954" "False" "High" "IsMasterProtein" "Q9H1E3" "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 OS=Homo sapiens OX=9606 GN=NUCKS1 PE=1 SV=1" "0.000" "False" "30.755" "39" "7" "16" "7" "243" "27.3" "5.08" "51.37" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "64710" "ENSG00000069275" "NUCKS1" "hsa:64710; Q54AC0; Q5PXE7; Q9H1D6; Q9H1E3; Q9H723" "" "" "0" "0" "0.845" "0.999" "0.907" "0.967" "0.997" "1.003" "0.968" "0.810" "0.501" "961.7" "812.8" "960.3" "871.9" "930.1" "958.5" "964.6" "931.0" "779.2" "481.5" "" "" "" "" "" "" "" "" "" "" "575.5" "422.4" "531.8" "409.3" "431.1" "490.7" "448.5" "418.0" "422.8" "481.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2214301499697937672" "False" "High" "IsMasterProtein" "Q96C86" "m7GpppX diphosphatase OS=Homo sapiens OX=9606 GN=DCPS PE=1 SV=2" "0.000" "False" "30.594" "25" "9" "23" "9" "337" "38.6" "6.38" "57.76" "9" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05652, Pf11969" "28960" "ENSG00000110063" "DCPS" "hsa:28960; Q8NHL8; Q96C86; Q9Y2S5" "" "mRNA decay by 3' to 5' exoribonuclease" "1" "0" "0.980" "1.016" "1.061" "1.088" "1.047" "1.038" "1.061" "1.049" "0.625" "1190.4" "1166.2" "1209.3" "1263.4" "1294.8" "1246.5" "1235.5" "1262.9" "1249.3" "743.7" "" "" "" "" "" "" "" "" "" "" "712.4" "606.0" "669.7" "593.1" "600.2" "638.1" "574.5" "567.0" "677.8" "743.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7705238959085991770" "False" "High" "IsMasterProtein" "P08865" "Small ribosomal subunit protein uS2 OS=Homo sapiens OX=9606 GN=RPSA PE=1 SV=4" "0.000" "False" "30.571" "19" "5" "27" "5" "295" "32.8" "4.87" "79.05" "5" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;translational apparatus;nucleus;other cell component" "translation activity;other molecular function" "Pf00318, Pf16122" "3921" "ENSG00000168028" "RPSA" "hsa:3921; P08865; P11085; P12030; Q16471; Q6IPD1; Q6IPD2; Q6NSD1; Q6NXQ8; Q86VC0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.052" "0.986" "1.182" "1.098" "1.118" "1.186" "1.089" "1.184" "1.781" "1152.1" "1211.6" "1135.5" "1362.2" "1264.8" "1288.4" "1366.6" "1255.0" "1364.1" "2051.5" "" "" "" "" "" "" "" "" "" "" "689.5" "629.6" "628.8" "639.5" "586.3" "659.6" "635.4" "563.4" "740.1" "2051.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7375658416039081200" "False" "High" "IsMasterProtein" "Q9GZU8" "PSME3-interacting protein OS=Homo sapiens OX=9606 GN=PSME3IP1 PE=1 SV=1" "0.000" "False" "30.567" "32" "9" "23" "9" "254" "28.9" "5.45" "55.97" "9" "other biological processes" "nucleus;other cell component" "" "Pf10187" "80011" "ENSG00000172775" "PSME3IP1" "hsa:80011; Q9GZU8" "" "" "0" "0" "1.050" "1.015" "1.123" "1.096" "1.015" "1.200" "1.062" "0.967" "0.512" "1044.3" "1096.7" "1060.0" "1173.1" "1144.8" "1060.0" "1253.5" "1108.9" "1010.1" "534.7" "" "" "" "" "" "" "" "" "" "" "624.9" "569.9" "587.0" "550.7" "530.6" "542.7" "582.8" "497.8" "548.0" "534.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4764020307768204184" "False" "High" "IsMasterProtein" "P61586" "Transforming protein RhoA OS=Homo sapiens OX=9606 GN=RHOA PE=1 SV=1" "0.000" "False" "30.526" "28" "5" "27" "5" "193" "21.8" "6.10" "75.39" "5" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "387" "ENSG00000067560" "RHOA" "hsa:387; P06749; P61586; Q53HM4; Q5U024; Q9UDJ0; Q9UEJ4" "Androgen receptor signaling pathway; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Leptin signaling pathway; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; Focal adhesion; G protein signaling pathways; Wnt signaling pathway; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency; Fibrin complement receptor 3 signaling pathway; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Leukocyte-intrinsic Hippo pathway functions; Neural crest cell migration during development; Neural crest cell migration in cancer; Joubert syndrome; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; GDNF signaling; PtdIns(4,5)P2 in cytokinesis pathway; 2q11.2 copy number variation syndrome; 2q21.1 copy number variation syndrome; G13 signaling pathway; 13q12.12 copy number variation; GNAQ pathways in port-wine stain; DNA damage response (only ATM dependent); Serotonin HTR1 group and FOS pathway" "Neutrophil degranulation; VEGFA-VEGFR2 Pathway; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHO GTPases Activate Formins; EPHB-mediated forward signaling; GPVI-mediated activation cascade; PI3K/AKT activation; ERBB2 Regulates Cell Motility; RHO GTPases activate CIT; G beta:gamma signalling through PI3Kgamma; PCP/CE pathway; RHO GTPases Activate Rhotekin and Rhophilins; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; Sema4D mediated inhibition of cell attachment and migration; Ovarian tumor domain proteases; SLIT2:ROBO1 increases RHOA activity; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Axonal growth stimulation; Axonal growth inhibition (RHOA activation); RHO GTPases activate KTN1" "71" "0" "1.054" "1.095" "0.996" "1.045" "0.966" "0.927" "0.961" "1.040" "0.897" "2060.5" "2172.2" "2255.6" "2051.7" "2153.5" "1989.9" "1909.2" "1981.1" "2142.5" "1848.0" "" "" "" "" "" "" "" "" "" "" "1233.1" "1128.8" "1249.1" "963.2" "998.2" "1018.7" "887.7" "889.4" "1162.4" "1848.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5185588165699995097" "False" "High" "IsMasterProtein" "P20290" "Transcription factor BTF3 OS=Homo sapiens OX=9606 GN=BTF3 PE=1 SV=1" "0.000" "False" "30.497" "42" "6" "16" "5" "206" "22.2" "9.38" "37.36" "6" "transport;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "" "Pf01849" "689" "ENSG00000145741" "BTF3" "A8K510; hsa:689; P20290; Q13893; Q76M56" "Orexin receptor pathway" "" "1" "1" "0.964" "1.062" "1.188" "1.234" "0.999" "1.378" "1.084" "1.135" "0.588" "890.9" "859.1" "945.8" "1058.8" "1099.7" "890.0" "1227.8" "965.9" "1011.0" "523.9" "" "" "" "" "" "" "" "" "" "" "533.2" "446.5" "523.7" "497.1" "509.7" "455.6" "570.9" "433.7" "548.5" "523.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3973865475325375053" "False" "High" "IsMasterProtein" "P15374" "Ubiquitin carboxyl-terminal hydrolase isozyme L3 OS=Homo sapiens OX=9606 GN=UCHL3 PE=1 SV=1" "0.000" "False" "30.442" "33" "6" "24" "6" "230" "26.2" "4.92" "66.89" "6" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01088" "7347" "ENSG00000118939" "UCHL3" "B2R970; hsa:7347; P15374; Q5TBK8; Q6IBE9" "Proteasome degradation" "UCH proteinases; Neddylation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "4" "0" "1.203" "1.214" "1.138" "1.212" "1.139" "1.071" "1.086" "1.175" "1.397" "895.2" "1077.2" "1086.7" "1019.1" "1084.9" "1019.9" "958.8" "972.0" "1052.0" "1250.6" "" "" "" "" "" "" "" "" "" "" "535.8" "559.8" "601.8" "478.4" "502.9" "522.1" "445.8" "436.4" "570.7" "1250.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "647250025127974157" "False" "High" "IsMasterProtein" "Q15004" "PCNA-associated factor OS=Homo sapiens OX=9606 GN=PCLAF PE=1 SV=1" "0.000" "False" "30.365" "60" "6" "18" "6" "111" "12.0" "9.83" "47.00" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15715" "9768" "ENSG00000166803" "PCLAF" "A6NNU5; A8K3Y3; G9G694; G9G696; hsa:9768; Q15004" "" "Termination of translesion DNA synthesis" "1" "0" "0.977" "0.999" "1.002" "1.091" "1.068" "1.868" "2.159" "1.741" "0.596" "678.3" "662.7" "677.7" "679.9" "739.9" "724.6" "1266.9" "1464.7" "1180.8" "404.2" "" "" "" "" "" "" "" "" "" "" "405.9" "344.4" "375.3" "319.2" "343.0" "371.0" "589.1" "657.6" "640.6" "404.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5216931438576770944" "False" "High" "IsMasterProtein" "Q9UK76" "Jupiter microtubule associated homolog 1 OS=Homo sapiens OX=9606 GN=JPT1 PE=1 SV=3" "0.000" "False" "30.288" "47" "5" "13" "5" "154" "16.0" "5.60" "35.03" "5" "" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf17054" "51155" "ENSG00000189159" "JPT1" "B2R6K3; hsa:51155; Q53FG7; Q7Z2D2; Q7Z2F0; Q9UK76" "" "" "0" "0" "1.068" "1.043" "1.022" "1.147" "1.023" "1.072" "1.143" "0.978" "0.542" "680.0" "726.3" "709.1" "695.3" "779.7" "695.3" "729.2" "777.4" "665.1" "368.3" "" "" "" "" "" "" "" "" "" "" "406.9" "377.4" "392.7" "326.4" "361.4" "355.9" "339.1" "349.0" "360.8" "368.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4877506006391296740" "False" "High" "IsMasterProtein" "P28072" "Proteasome subunit beta type-6 OS=Homo sapiens OX=9606 GN=PSMB6 PE=1 SV=4" "0.000" "False" "30.275" "23" "6" "32" "6" "239" "25.3" "4.92" "87.01" "6" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00227" "5694" "ENSG00000142507" "PSMB6" "hsa:5694; P28072; Q96J55" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; SCF(Skp2)-mediated degradation of p27/p21; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "1.042" "0.959" "1.042" "0.995" "0.920" "0.995" "1.117" "1.079" "0.650" "1555.7" "1621.3" "1492.4" "1621.7" "1548.2" "1431.4" "1547.5" "1737.8" "1678.8" "1011.0" "" "" "" "" "" "" "" "" "" "" "931.0" "842.5" "826.5" "761.4" "717.6" "732.8" "719.6" "780.2" "910.8" "1011.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3428809261446700766" "False" "High" "IsMasterProtein" "Q9UNN5" "FAS-associated factor 1 OS=Homo sapiens OX=9606 GN=FAF1 PE=1 SV=2" "0.000" "False" "30.260" "12" "8" "11" "8" "650" "73.9" "4.88" "35.33" "8" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00789, Pf14555, Pf21021" "11124" "ENSG00000185104" "FAF1" "hsa:11124; Q549F0; Q9UF34; Q9UNN5; Q9UNT3; Q9Y2Z3" "Retinoblastoma gene in cancer; Fas ligand pathway and stress induction of heat shock proteins; VEGFA-VEGFR2 signaling" "" "3" "0" "1.018" "0.973" "1.004" "0.999" "1.003" "0.995" "0.922" "0.962" "0.985" "940.5" "957.2" "915.2" "944.4" "939.2" "942.9" "936.0" "867.3" "904.8" "926.0" "" "" "" "" "" "" "" "" "" "" "562.8" "497.4" "506.8" "443.4" "435.3" "482.7" "435.2" "389.4" "490.9" "926.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3390977729729594241" "False" "High" "IsMasterProtein" "P14735" "Insulin-degrading enzyme OS=Homo sapiens OX=9606 GN=IDE PE=1 SV=4" "0.000" "False" "30.252" "9" "9" "15" "9" "1019" "117.9" "6.61" "26.92" "9" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00675, Pf05193, Pf16187" "3416" "ENSG00000119912" "IDE" "B2R721; B7ZAU2; D3DR35; hsa:3416; P14735; Q5T5N2" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "Ub-specific processing proteases; Peroxisomal protein import; Insulin receptor recycling" "5" "0" "1.014" "1.102" "1.094" "1.099" "1.043" "1.055" "0.949" "1.058" "2.428" "220.3" "223.3" "242.8" "241.0" "242.2" "229.8" "232.4" "209.1" "233.2" "535.0" "" "" "" "" "" "" "" "" "" "" "131.9" "116.1" "134.4" "113.1" "112.3" "117.6" "108.1" "93.9" "126.5" "535.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4457645785715096452" "False" "High" "IsMasterProtein" "Q9BS26" "Endoplasmic reticulum resident protein 44 OS=Homo sapiens OX=9606 GN=ERP44 PE=1 SV=1" "0.000" "False" "30.215" "18" "7" "16" "6" "406" "46.9" "5.26" "47.83" "7" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00085, Pf13848" "23071" "ENSG00000023318" "ERP44" "hsa:23071; O60319; Q4VXC1; Q5VWZ7; Q6UW14; Q8WX67; Q9BS26" "" "Neutrophil degranulation" "1" "0" "0.980" "1.110" "1.079" "1.004" "1.066" "0.958" "1.043" "0.988" "1.018" "252.3" "247.3" "280.0" "272.3" "253.3" "268.9" "241.7" "263.1" "249.2" "257.0" "" "" "" "" "" "" "" "" "" "" "151.0" "128.5" "155.0" "127.8" "117.4" "137.6" "112.4" "118.1" "135.2" "257.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4952075756115425488" "False" "High" "IsMasterProtein" "Cont_P34955" "Alpha-1-antiproteinase OS=Bos taurus OX=9913 GN=SERPINA1 PE=1 SV=1" "0.000" "True" "30.178" "19" "8" "13" "8" "416" "46.1" "6.52" "42.29" "8" "" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00079" "109575576; 280699" "ENSBIXG00000014418; ENSBIXG00005018236; ENSBTAG00000018843" "SERPINA1" "A0A4W2DYT6; A0A6P5DQE7; biu:109575576; bta:280699; P34955; Q3SZS3" "Complement and coagulation cascades; NRF2 pathway" "Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo concentration in the ER; COPII-mediated vesicle transport" "8" "0" "1.218" "1.156" "1.125" "0.971" "0.913" "1.391" "1.136" "1.198" "0.666" "1413.8" "1722.6" "1633.9" "1589.9" "1373.2" "1291.4" "1966.4" "1605.5" "1693.9" "942.1" "" "" "" "" "" "" "" "" "" "" "846.1" "895.2" "904.8" "746.4" "636.5" "661.1" "914.4" "720.8" "919.0" "942.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3545967028758689053" "False" "High" "IsMasterProtein" "P36543" "V-type proton ATPase subunit E 1 OS=Homo sapiens OX=9606 GN=ATP6V1E1 PE=1 SV=1" "0.000" "False" "30.164" "27" "6" "21" "6" "226" "26.1" "8.00" "54.54" "6" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf01991" "529" "ENSG00000131100" "ATP6V1E1" "A8MUE4; A8MUN4; hsa:529; P36543" "VEGFA-VEGFR2 signaling; Proximal tubule transport" "Insulin receptor recycling; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Transferrin endocytosis and recycling; Ion channel transport" "7" "0" "1.088" "1.040" "1.073" "1.079" "1.023" "1.014" "1.033" "1.033" "1.000" "724.9" "789.0" "754.2" "777.9" "782.2" "741.6" "735.1" "748.9" "748.7" "724.6" "" "" "" "" "" "" "" "" "" "" "433.8" "410.0" "417.6" "365.2" "362.6" "379.7" "341.8" "336.2" "406.2" "724.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3620399161639766887" "False" "High" "IsMasterProtein" "Q99471" "Prefoldin subunit 5 OS=Homo sapiens OX=9606 GN=PFDN5 PE=1 SV=2" "0.000" "False" "30.154" "36" "5" "17" "5" "154" "17.3" "6.33" "51.56" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf02996" "5204" "ENSG00000123349; ENSG00000291834" "PFDN5" "A8K9A8; hsa:5204; Q54AA8; Q99471; Q9C083; Q9C084" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "1.011" "0.981" "0.988" "1.136" "1.045" "1.121" "1.034" "1.073" "0.637" "958.9" "969.5" "941.0" "947.6" "1089.3" "1001.9" "1074.6" "991.1" "1028.5" "610.8" "" "" "" "" "" "" "" "" "" "" "573.8" "503.8" "521.1" "444.9" "504.9" "512.9" "499.7" "444.9" "558.0" "610.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7577661902964436810" "False" "High" "IsMasterProtein" "Q3LXA3" "Triokinase/FMN cyclase OS=Homo sapiens OX=9606 GN=TKFC PE=1 SV=2" "0.000" "False" "30.072" "16" "9" "28" "9" "575" "58.9" "7.49" "54.25" "9" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf02733, Pf02734" "26007" "ENSG00000149476" "TKFC" "hsa:26007; Q2L9C1; Q3LXA3; Q53EQ9; Q9BVA7; Q9H895" "Novel intracellular components of RIG-I-like receptor pathway" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; SARS-CoV-1 activates/modulates innate immune responses; DDX58/IFIH1-mediated induction of interferon-alpha/beta; Fructose catabolism" "5" "0" "1.047" "0.933" "1.047" "1.015" "1.049" "1.043" "1.069" "0.979" "0.673" "1978.1" "2070.5" "1844.6" "2071.2" "2006.9" "2075.0" "2063.5" "2114.2" "1935.9" "1331.0" "" "" "" "" "" "" "" "" "" "" "1183.8" "1076.0" "1021.5" "972.4" "930.2" "1062.3" "959.5" "949.2" "1050.3" "1331.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1785172786280045072" "False" "High" "IsMasterProtein" "P06730" "Eukaryotic translation initiation factor 4E OS=Homo sapiens OX=9606 GN=EIF4E PE=1 SV=2" "0.000" "False" "30.047" "27" "5" "15" "5" "217" "25.1" "6.15" "46.74" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01652" "1977" "ENSG00000151247" "EIF4E" "B7Z6V1; D6RCQ6; hsa:1977; P06730; Q96E95" "Translation factors; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Interleukin-1 (IL-1) structural pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prader-Willi and Angelman syndrome; PI3K-Akt signaling pathway; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Hypertrophy model; Interferon type I signaling pathways" "M-decay: degradation of maternal mRNAs by maternally stored factors; Deadenylation of mRNA; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "33" "0" "1.015" "0.961" "1.100" "1.021" "1.028" "1.025" "1.032" "1.001" "1.083" "1085.6" "1102.2" "1042.7" "1194.2" "1108.4" "1116.1" "1112.2" "1120.6" "1086.9" "1175.2" "" "" "" "" "" "" "" "" "" "" "649.7" "572.8" "577.4" "560.6" "513.8" "571.4" "517.2" "503.1" "589.7" "1175.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2495561624923528868" "False" "High" "IsMasterProtein" "Q10567" "AP-1 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP1B1 PE=1 SV=3" "0.000" "False" "30.047" "9" "10" "14" "4" "949" "104.5" "5.06" "33.92" "10" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02883, Pf09066" "162" "ENSG00000100280" "AP1B1" "C9JRD1; F8WDL0; hsa:162; P78436; Q10567; Q20WL3; Q86X54" "" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "4" "5" "0.972" "0.973" "0.927" "1.042" "1.122" "0.985" "1.009" "1.006" "1.787" "794.5" "772.6" "772.9" "736.7" "828.0" "891.8" "782.7" "801.8" "799.4" "1419.6" "" "" "" "" "" "" "" "" "" "" "475.5" "401.5" "428.0" "345.8" "383.8" "456.5" "364.0" "360.0" "433.7" "1419.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6271968905262141895" "False" "High" "IsMasterProtein" "Q4VC31" "Protein MIX23 OS=Homo sapiens OX=9606 GN=MIX23 PE=1 SV=1" "0.000" "False" "30.008" "51" "6" "9" "6" "144" "16.6" "7.81" "32.37" "6" "" "mitochondrion" "" "Pf09774" "131076" "ENSG00000160124" "MIX23" "hsa:131076; Q32LY6; Q4VC31" "" "" "0" "0" "1.009" "0.986" "0.959" "1.059" "1.003" "0.980" "0.958" "0.904" "0.518" "552.2" "556.9" "544.6" "529.5" "584.6" "553.9" "540.9" "528.9" "499.3" "285.8" "" "" "" "" "" "" "" "" "" "" "330.4" "289.4" "301.6" "248.6" "271.0" "283.6" "251.5" "237.4" "270.9" "285.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6934522081491213014" "False" "High" "IsMasterProtein" "P11908" "Ribose-phosphate pyrophosphokinase 2 OS=Homo sapiens OX=9606 GN=PRPS2 PE=1 SV=2" "0.000" "False" "29.977" "18" "6" "34" "2" "318" "34.7" "6.61" "91.61" "6" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf13793, Pf14572" "5634" "ENSG00000101911" "PRPS2" "hsa:5634; P11908; Q0VDH9; Q0VDI0; Q15245; Q2TAK7" "" "5-Phosphoribose 1-diphosphate biosynthesis" "1" "0" "0.993" "0.965" "1.111" "0.956" "1.069" "0.962" "1.132" "1.137" "0.679" "1862.8" "1849.0" "1798.3" "2069.5" "1781.3" "1990.7" "1791.7" "2109.6" "2117.7" "1264.8" "" "" "" "" "" "" "" "" "" "" "1114.8" "960.8" "995.9" "971.6" "825.7" "1019.1" "833.1" "947.1" "1149.0" "1264.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3946682035619075212" "False" "High" "IsMasterProtein" "Q00688" "Peptidyl-prolyl cis-trans isomerase FKBP3 OS=Homo sapiens OX=9606 GN=FKBP3 PE=1 SV=1" "0.000" "False" "29.810" "29" "6" "11" "6" "224" "25.2" "9.28" "38.44" "6" "" "nucleus" "other molecular function" "Pf00254, Pf18410" "2287" "ENSG00000100442" "FKBP3" "B2R4Q9; hsa:2287; Q00688; Q14317" "" "" "0" "0" "1.039" "0.978" "1.073" "1.107" "1.042" "1.093" "1.125" "0.981" "0.672" "1295.1" "1345.7" "1266.3" "1390.0" "1433.5" "1349.0" "1415.7" "1457.1" "1270.6" "870.1" "" "" "" "" "" "" "" "" "" "" "775.1" "699.3" "701.2" "652.6" "664.4" "690.6" "658.3" "654.1" "689.4" "870.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6456635449604072928" "False" "High" "IsMasterProtein" "P30419" "Glycylpeptide N-tetradecanoyltransferase 1 OS=Homo sapiens OX=9606 GN=NMT1 PE=1 SV=2" "0.000" "False" "29.616" "17" "7" "18" "7" "496" "56.8" "7.80" "44.78" "7" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf01233, Pf02799" "4836" "ENSG00000136448" "NMT1" "A8K7C1; hsa:4836; P30419; Q9UE09" "" "Inactivation, recovery and regulation of the phototransduction cascade; Late Phase of HIV Life Cycle; Activation, myristolyation of BID and translocation to mitochondria" "3" "0" "1.134" "0.938" "1.091" "1.065" "1.071" "0.982" "1.093" "0.995" "0.856" "1150.0" "1304.0" "1078.8" "1254.4" "1224.4" "1232.1" "1129.2" "1256.7" "1144.7" "984.4" "" "" "" "" "" "" "" "" "" "" "688.2" "677.6" "597.4" "588.9" "567.5" "630.7" "525.0" "564.2" "621.1" "984.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2283450593618715734" "False" "High" "IsMasterProtein" "P41240" "Tyrosine-protein kinase CSK OS=Homo sapiens OX=9606 GN=CSK PE=1 SV=1" "0.000" "False" "29.616" "17" "8" "14" "8" "450" "50.7" "7.06" "35.06" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "1445" "ENSG00000103653" "CSK" "P41240; Q2M3N2; Q6FGZ6" "Integrin-mediated cell adhesion; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton" "Negative regulation of FLT3; Phosphorylation of CD3 and TCR zeta chains; PD-1 signaling; Signaling by BRAF and RAF1 fusions; GAB1 signalosome; Integrin signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; RHOH GTPase cycle; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "18" "0" "0.991" "0.981" "0.988" "0.952" "0.948" "0.988" "0.528" "0.920" "6.692" "267.2" "264.9" "262.1" "264.0" "254.3" "253.2" "264.1" "141.2" "245.8" "1787.9" "" "" "" "" "" "" "" "" "" "" "159.9" "137.6" "145.1" "124.0" "117.9" "129.6" "122.8" "63.4" "133.4" "1787.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7576876112341409561" "False" "High" "IsMasterProtein" "O43813" "Glutathione S-transferase LANCL1 OS=Homo sapiens OX=9606 GN=LANCL1 PE=1 SV=1" "0.000" "False" "29.491" "24" "9" "14" "9" "399" "45.3" "7.75" "35.15" "9" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05147" "10314" "ENSG00000115365" "LANCL1" "hsa:10314; O43813" "" "" "0" "0" "1.036" "0.952" "1.025" "0.980" "1.049" "0.941" "0.999" "1.009" "0.610" "1002.7" "1039.2" "954.5" "1027.3" "982.2" "1052.0" "943.6" "1001.2" "1011.6" "611.2" "" "" "" "" "" "" "" "" "" "" "600.0" "540.0" "528.6" "482.3" "455.3" "538.5" "438.7" "449.5" "548.8" "611.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2598946853791074460" "False" "High" "IsMasterProtein" "Q9Y295" "Developmentally-regulated GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=DRG1 PE=1 SV=1" "0.000" "False" "29.489" "21" "7" "13" "6" "367" "40.5" "8.90" "35.60" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01926, Pf02824, Pf16897" "4733" "ENSG00000185721" "DRG1" "B2RDS8; hsa:4733; Q6FGP8; Q8WW69; Q9UGF2; Q9Y295" "" "Protein hydroxylation" "1" "1" "0.994" "0.843" "0.985" "1.013" "1.065" "1.064" "1.027" "1.010" "0.918" "538.4" "535.2" "453.9" "530.1" "545.3" "573.6" "573.1" "552.8" "543.9" "494.4" "" "" "" "" "" "" "" "" "" "" "322.2" "278.1" "251.3" "248.9" "252.8" "293.6" "266.5" "248.2" "295.1" "494.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "945585302651271031" "False" "High" "IsMasterProtein" "P43243" "Matrin-3 OS=Homo sapiens OX=9606 GN=MATR3 PE=1 SV=2" "0.000" "False" "29.480" "12" "9" "13" "9" "847" "94.6" "6.25" "28.49" "9" "stress response;developmental processes;other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "" "9782" "ENSG00000015479" "MATR3" "B7ZAV5; D3DQC3; hsa:9782; P43243; Q9UHW0; Q9UQ27" "" "" "0" "0" "1.200" "1.183" "1.116" "1.293" "1.133" "1.070" "0.702" "1.341" "6.444" "155.9" "187.0" "184.5" "173.9" "201.5" "176.7" "166.8" "109.4" "209.0" "1004.5" "" "" "" "" "" "" "" "" "" "" "93.3" "97.2" "102.2" "81.7" "93.4" "90.4" "77.6" "49.1" "113.4" "1004.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2971731893176673056" "False" "High" "IsMasterProtein" "O15305" "Phosphomannomutase 2 OS=Homo sapiens OX=9606 GN=PMM2 PE=1 SV=1" "0.000" "False" "29.468" "30" "7" "18" "7" "246" "28.1" "6.77" "36.51" "7" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03332" "5373" "ENSG00000140650" "PMM2" "A8K672; B7Z6R0; D3DUF3; hsa:5373; O15305" "Nephrotic syndrome; N-glycan biosynthesis; Primary ovarian insufficiency" "Defective PMM2 causes PMM2-CDG; Synthesis of GDP-mannose" "5" "0" "1.029" "1.055" "1.048" "0.954" "1.025" "1.011" "1.050" "0.991" "0.822" "1045.2" "1075.6" "1102.9" "1094.9" "997.6" "1071.3" "1056.2" "1097.6" "1035.7" "858.9" "" "" "" "" "" "" "" "" "" "" "625.5" "559.0" "610.7" "514.0" "462.4" "548.4" "491.1" "492.7" "561.9" "858.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2190744193783032342" "False" "High" "IsMasterProtein" "Q92619" "Rho GTPase-activating protein 45 OS=Homo sapiens OX=9606 GN=ARHGAP45 PE=1 SV=2" "0.000" "False" "29.450" "9" "9" "10" "9" "1136" "124.5" "6.10" "30.01" "9" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00620" "23526" "ENSG00000180448" "ARHGAP45" "B4DTS4; F6QP70; hsa:23526; Q6P189; Q7LE26; Q86WS1; Q8HX84; Q92619; Q9GJN9; Q9GJP0; Q9GJP1; Q9MY24" "" "Neutrophil degranulation; RAC1 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle" "4" "0" "1.143" "1.076" "1.095" "1.244" "1.164" "1.184" "1.054" "1.066" "2.974" "402.7" "460.1" "433.4" "441.2" "501.0" "468.8" "476.7" "424.5" "429.4" "1197.6" "" "" "" "" "" "" "" "" "" "" "241.0" "239.1" "240.0" "207.1" "232.2" "240.0" "221.7" "190.6" "233.0" "1197.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5136159273712408888" "False" "High" "IsMasterProtein" "P38919" "Eukaryotic initiation factor 4A-III OS=Homo sapiens OX=9606 GN=EIF4A3 PE=1 SV=4" "0.000" "False" "29.365" "19" "8" "16" "6" "411" "46.8" "6.73" "44.45" "8" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "9775" "ENSG00000141543; ENSG00000291508" "EIF4A3" "hsa:9775; P38919; Q15033; Q6IBQ2; Q96A18" "TAR syndrome" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "11" "0" "1.055" "0.968" "1.078" "1.005" "1.148" "1.058" "1.173" "1.039" "1.042" "809.9" "854.5" "783.7" "873.4" "813.6" "930.0" "856.5" "950.1" "841.6" "843.8" "" "" "" "" "" "" "" "" "" "" "484.7" "444.1" "434.0" "410.0" "377.1" "476.1" "398.2" "426.5" "456.6" "843.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7866800410965669169" "False" "High" "IsMasterProtein" "Q9H0G5" "Nuclear speckle splicing regulatory protein 1 OS=Homo sapiens OX=9606 GN=NSRP1 PE=1 SV=1" "0.000" "False" "29.323" "11" "6" "10" "6" "558" "66.4" "8.84" "27.64" "6" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09745, Pf20427" "84081" "ENSG00000126653" "NSRP1" "hsa:84081; Q6FI71; Q9H0G5" "" "mRNA Splicing - Major Pathway" "1" "0" "0.925" "0.894" "0.858" "0.983" "1.002" "0.955" "1.036" "0.927" "0.372" "402.5" "372.3" "359.6" "345.4" "395.6" "403.3" "384.4" "417.0" "373.2" "149.5" "" "" "" "" "" "" "" "" "" "" "240.9" "193.5" "199.2" "162.2" "183.4" "206.5" "178.8" "187.2" "202.5" "149.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2651873567954206530" "False" "High" "IsMasterProtein" "Q9P2J5" "Leucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=LARS1 PE=1 SV=2" "0.000" "False" "29.287" "7" "7" "8" "7" "1176" "134.4" "7.30" "23.30" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00133, Pf08264" "51520" "ENSG00000133706" "LARS1" "A2RRR4; A7E266; B4DJ10; hsa:51520; Q2TU79; Q9NSE1; Q9P2J5" "" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "2" "0" "0.964" "0.881" "1.092" "0.984" "0.979" "0.972" "0.353" "0.891" "6.594" "143.9" "138.7" "126.8" "157.2" "141.6" "140.9" "139.9" "50.9" "128.2" "949.1" "" "" "" "" "" "" "" "" "" "" "86.1" "72.1" "70.2" "73.8" "65.6" "72.1" "65.0" "22.8" "69.6" "949.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "626595147841982495" "False" "High" "IsMasterProtein" "Q92835" "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 OS=Homo sapiens OX=9606 GN=INPP5D PE=1 SV=2" "0.000" "False" "29.239" "9" "9" "11" "9" "1189" "133.2" "7.59" "31.34" "9" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "other molecular function" "Pf00017" "3635" "ENSG00000168918; ENSG00000281614" "INPP5D" "hsa:3635; O00145; Q13544; Q13545; Q6P5A4; Q92656; Q92835; Q9UE80" "B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; IL-4 signaling pathway; EGF/EGFR signaling pathway; Netrin-UNC5B signaling pathway; 5q35 copy number variation" "Downstream TCR signaling; Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Synthesis of IP3 and IP4 in the cytosol; Signaling by CSF1 (M-CSF) in myeloid cells; PECAM1 interactions" "13" "0" "1.036" "1.056" "1.082" "1.073" "1.077" "1.062" "0.922" "1.131" "3.054" "179.4" "185.8" "189.5" "194.1" "192.5" "193.3" "190.5" "165.4" "202.9" "548.0" "" "" "" "" "" "" "" "" "" "" "107.4" "96.6" "104.9" "91.1" "89.2" "99.0" "88.6" "74.3" "110.1" "548.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7717168989126712836" "False" "High" "IsMasterProtein" "Q8TAF3" "WD repeat-containing protein 48 OS=Homo sapiens OX=9606 GN=WDR48 PE=1 SV=1" "0.000" "False" "29.219" "13" "9" "10" "9" "677" "76.2" "7.03" "28.61" "9" "DNA metabolism;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00400, Pf11816" "57599" "ENSG00000114742" "WDR48" "B4DM86; B4DQI2; B4DY84; hsa:57599; Q63HJ2; Q658Y1; Q8N3Z1; Q8TAF3; Q9NSK8; Q9P279" "DNA repair pathways, full network" "Ub-specific processing proteases; Fanconi Anemia Pathway; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins; Recognition of DNA damage by PCNA-containing replication complex" "5" "0" "1.049" "0.991" "1.046" "1.039" "1.035" "0.930" "0.866" "0.979" "0.817" "784.5" "822.9" "777.4" "820.7" "814.9" "812.3" "729.6" "679.4" "767.8" "641.1" "" "" "" "" "" "" "" "" "" "" "469.5" "427.6" "430.5" "385.3" "377.7" "415.8" "339.2" "305.0" "416.5" "641.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6626039175338175676" "False" "High" "IsMasterProtein" "Q9NXH9" "tRNA (guanine(26)-N(2))-dimethyltransferase OS=Homo sapiens OX=9606 GN=TRMT1 PE=1 SV=1" "0.000" "False" "29.201" "13" "8" "14" "8" "659" "72.2" "7.64" "32.50" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00642, Pf02005" "55621" "ENSG00000104907" "TRMT1" "hsa:55621; O76103; Q548Y5; Q8WVA6; Q9NXH9" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.077" "0.962" "0.980" "0.942" "0.772" "0.863" "0.763" "0.848" "0.607" "99.3" "106.9" "95.5" "97.3" "93.5" "76.6" "85.7" "75.8" "84.2" "60.3" "" "" "" "" "" "" "" "" "" "" "59.4" "55.6" "52.9" "45.7" "43.3" "39.2" "39.8" "34.0" "45.7" "60.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2222820814571899525" "False" "High" "IsMasterProtein" "Q9UJ70" "N-acetyl-D-glucosamine kinase OS=Homo sapiens OX=9606 GN=NAGK PE=1 SV=4" "0.000" "False" "29.099" "22" "7" "18" "7" "344" "37.4" "6.24" "46.91" "7" "other metabolic processes;stress response;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf01869" "55577" "ENSG00000124357" "NAGK" "B4DLZ5; hsa:55577; Q53HD5; Q6IA84; Q9BS29; Q9BVP0; Q9NV37; Q9UJ70" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "0" "0.947" "0.918" "1.045" "0.963" "1.010" "0.944" "0.978" "0.914" "0.564" "496.3" "469.8" "455.6" "518.8" "478.0" "501.1" "468.3" "485.4" "453.5" "280.0" "" "" "" "" "" "" "" "" "" "" "297.0" "244.1" "252.3" "243.6" "221.6" "256.5" "217.8" "217.9" "246.0" "280.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6460055541994458794" "False" "High" "IsMasterProtein" "Q14019" "Coactosin-like protein OS=Homo sapiens OX=9606 GN=COTL1 PE=1 SV=3" "0.000" "False" "29.081" "55" "8" "49" "8" "142" "15.9" "5.67" "112.94" "8" "cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "23406" "ENSG00000103187" "COTL1" "B2RDU3; D3DUL9; hsa:23406; Q14019; Q86XM5" "" "Neutrophil degranulation" "1" "0" "1.017" "1.027" "0.993" "0.958" "0.951" "0.907" "0.960" "0.956" "0.785" "4807.3" "4887.7" "4937.4" "4772.2" "4605.8" "4573.7" "4362.6" "4614.5" "4594.4" "3773.2" "" "" "" "" "" "" "" "" "" "" "2876.9" "2540.0" "2734.2" "2240.4" "2134.9" "2341.4" "2028.5" "2071.6" "2492.6" "3773.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6835034816184829460" "False" "High" "IsMasterProtein" "Q13363" "C-terminal-binding protein 1 OS=Homo sapiens OX=9606 GN=CTBP1 PE=1 SV=2" "0.000" "False" "29.071" "20" "9" "20" "5" "440" "47.5" "6.77" "56.76" "9" "protein metabolism;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00389, Pf02826" "1487" "ENSG00000159692" "CTBP1" "Q13363; Q4W5N3; Q7Z2Q5" "Notch signaling; Ectoderm differentiation; Ectoderm differentiation; Wnt signaling pathway; Pathways affected in adenoid cystic carcinoma; Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma" "Deactivation of the beta-catenin transactivating complex; SUMOylation of transcription cofactors; Repression of WNT target genes; Signaling by TCF7L2 mutants" "14" "4" "0.987" "0.851" "0.868" "0.992" "0.986" "0.975" "0.967" "0.934" "0.716" "2643.1" "2608.6" "2250.0" "2293.5" "2622.0" "2605.0" "2576.7" "2557.0" "2467.9" "1892.4" "" "" "" "" "" "" "" "" "" "" "1581.8" "1355.6" "1246.0" "1076.7" "1215.4" "1333.5" "1198.1" "1147.9" "1339.0" "1892.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6459362278607736604" "False" "High" "IsMasterProtein" "Q9HB07" "MYG1 exonuclease OS=Homo sapiens OX=9606 GN=MYG1 PE=1 SV=4" "0.000" "False" "29.067" "18" "6" "17" "6" "376" "42.5" "6.84" "47.16" "6" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf03690" "60314" "ENSG00000139637; ENSG00000291835" "MYG1" "hsa:60314; Q86UA3; Q9HB07" "" "" "0" "0" "1.002" "1.005" "1.043" "1.024" "0.962" "1.125" "0.988" "1.037" "1.095" "869.1" "871.0" "873.8" "906.3" "890.2" "836.1" "977.3" "858.9" "901.5" "952.1" "" "" "" "" "" "" "" "" "" "" "520.1" "452.6" "483.9" "425.5" "412.6" "428.0" "454.4" "385.6" "489.1" "952.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8472410284542291541" "False" "High" "IsMasterProtein" "P61289" "Proteasome activator complex subunit 3 OS=Homo sapiens OX=9606 GN=PSME3 PE=1 SV=1" "0.000" "False" "29.034" "26" "8" "25" "8" "254" "29.5" "5.95" "52.86" "8" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02251, Pf02252" "10197" "ENSG00000131467" "PSME3" "A8K9A3; hsa:10197; O35563; P61289; P97373; Q12920; Q13172; Q9BQD9" "Proteasome degradation" "Regulation of expression of SLITs and ROBOs; ER-Phagosome pathway; Degradation of beta-catenin by the destruction complex; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Ubiquitin-dependent degradation of Cyclin D; Regulation of RUNX2 expression and activity; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling" "60" "0" "1.016" "0.977" "1.034" "0.950" "1.065" "1.031" "1.123" "1.011" "0.649" "1313.8" "1334.9" "1283.4" "1358.4" "1248.7" "1399.3" "1355.2" "1475.1" "1328.1" "852.5" "" "" "" "" "" "" "" "" "" "" "786.2" "693.7" "710.7" "637.7" "578.8" "716.3" "630.1" "662.3" "720.5" "852.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8178776459123092866" "False" "High" "IsMasterProtein" "P05387" "Large ribosomal subunit protein P2 OS=Homo sapiens OX=9606 GN=RPLP2 PE=1 SV=1" "0.000" "False" "29.032" "39" "5" "15" "3" "115" "11.7" "4.54" "35.62" "5" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00428" "6181" "ENSG00000177600" "RPLP2" "hsa:6181; P05387; Q6FG96" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins; Opioid receptor pathways" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "16" "1" "0.852" "0.916" "1.252" "1.163" "1.042" "1.190" "0.929" "0.978" "0.350" "747.6" "637.0" "685.1" "935.9" "869.2" "778.7" "889.9" "694.6" "731.1" "261.6" "" "" "" "" "" "" "" "" "" "" "447.4" "331.0" "379.4" "439.4" "402.9" "398.7" "413.8" "311.8" "396.7" "261.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6560846777174153588" "False" "High" "IsMasterProtein" "P53621" "Coatomer subunit alpha OS=Homo sapiens OX=9606 GN=COPA PE=1 SV=2" "0.000" "False" "29.000" "8" "9" "10" "9" "1224" "138.3" "7.66" "25.74" "9" "transport;signal transduction" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00400, Pf04053, Pf06957" "1314" "ENSG00000122218" "COPA" "hsa:1314; P53621; Q5T201; Q8IXZ9" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "1.052" "0.978" "0.953" "1.077" "1.242" "1.005" "0.930" "0.979" "2.794" "264.8" "278.5" "259.1" "252.5" "285.2" "328.8" "266.2" "246.2" "259.2" "740.0" "" "" "" "" "" "" "" "" "" "" "158.5" "144.7" "143.5" "118.6" "132.2" "168.3" "123.8" "110.5" "140.6" "740.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4752916691292977805" "False" "High" "IsMasterProtein" "Q15057" "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ACAP2 PE=1 SV=3" "0.000" "False" "28.991" "10" "6" "8" "6" "778" "88.0" "6.80" "20.01" "6" "transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01412, Pf12796, Pf16746" "23527" "ENSG00000114331" "ACAP2" "A8K2V4; hsa:23527; Q15057; Q8N5Z8; Q9UQR3" "" "" "0" "0" "1.104" "0.937" "0.999" "1.274" "1.015" "0.934" "0.437" "1.050" "6.638" "147.3" "162.5" "138.0" "147.1" "187.7" "149.5" "137.6" "64.3" "154.7" "977.7" "" "" "" "" "" "" "" "" "" "" "88.1" "84.5" "76.4" "69.0" "87.0" "76.6" "64.0" "28.9" "83.9" "977.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4326632445175340721" "False" "High" "IsMasterProtein" "P55209" "Nucleosome assembly protein 1-like 1 OS=Homo sapiens OX=9606 GN=NAP1L1 PE=1 SV=1" "0.000" "False" "28.962" "19" "5" "14" "4" "391" "45.3" "4.46" "32.94" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00956" "4673" "ENSG00000187109" "NAP1L1" "B3KNT8; B3KV44; hsa:4673; P55209" "VEGFA-VEGFR2 signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "" "2" "0" "1.292" "1.373" "0.997" "0.954" "1.214" "0.932" "0.469" "1.231" "5.002" "36.4" "47.0" "50.0" "36.3" "34.7" "44.2" "33.9" "17.1" "44.8" "182.1" "" "" "" "" "" "" "" "" "" "" "21.8" "24.4" "27.7" "17.0" "16.1" "22.6" "15.8" "7.7" "24.3" "182.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832676921386861974" "False" "High" "IsMasterProtein" "Q8WW33" "Gametocyte-specific factor 1 OS=Homo sapiens OX=9606 GN=GTSF1 PE=1 SV=2" "0.000" "False" "28.931" "39" "7" "16" "7" "167" "19.3" "6.51" "43.49" "7" "other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf05253" "121355" "ENSG00000170627" "GTSF1" "B3KQ60; hsa:121355; Q0VGM4; Q8N778; Q8WW33" "" "" "0" "0" "0.899" "0.985" "0.934" "1.004" "0.963" "0.939" "0.982" "0.944" "0.480" "745.5" "669.8" "733.9" "696.6" "748.3" "718.2" "700.2" "732.1" "703.6" "358.0" "" "" "" "" "" "" "" "" "" "" "446.1" "348.1" "406.4" "327.0" "346.9" "367.7" "325.6" "328.7" "381.7" "358.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2982172693089125932" "False" "High" "IsMasterProtein" "P28066" "Proteasome subunit alpha type-5 OS=Homo sapiens OX=9606 GN=PSMA5 PE=1 SV=3" "0.000" "False" "28.900" "29" "6" "21" "6" "241" "26.4" "4.79" "51.85" "6" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5686" "ENSG00000143106" "PSMA5" "B2R8F6; B4E2V4; hsa:5686; P28066; Q3T1C1; Q6IBF7" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "UCH proteinases; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "1.126" "1.114" "1.172" "1.124" "1.078" "1.116" "1.307" "1.244" "0.805" "736.7" "829.7" "820.7" "863.5" "827.9" "794.0" "822.1" "963.2" "916.1" "592.9" "" "" "" "" "" "" "" "" "" "" "440.9" "431.2" "454.5" "405.4" "383.8" "406.5" "382.3" "432.4" "497.0" "592.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5966605329502245695" "False" "High" "IsMasterProtein" "P10599" "Thioredoxin OS=Homo sapiens OX=9606 GN=TXN PE=1 SV=3" "0.000" "False" "28.822" "52" "4" "24" "4" "105" "11.7" "4.92" "70.51" "4" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00085" "7295" "ENSG00000136810" "TXN" "B1ALW1; hsa:7295; O60744; P10599; Q53X69; Q96KI3; Q9UDG5" "Selenium micronutrient network; Folic acid network; Selenium micronutrient network ; Folic acid network; Selenium micronutrient network; TNF-alpha signaling pathway; Complement system; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling; TAR syndrome" "Detoxification of Reactive Oxygen Species; Oxidative Stress Induced Senescence; TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates; NFE2L2 regulating anti-oxidant/detoxification enzymes; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Regulation of FOXO transcriptional activity by acetylation; Protein repair" "20" "0" "0.857" "0.869" "0.847" "0.956" "0.811" "1.027" "0.864" "0.822" "0.421" "2710.4" "2322.9" "2355.9" "2297.1" "2590.9" "2197.7" "2783.6" "2342.6" "2228.9" "1142.1" "" "" "" "" "" "" "" "" "" "" "1622.0" "1207.1" "1304.7" "1078.4" "1200.9" "1125.1" "1294.3" "1051.7" "1209.3" "1142.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4061147392346931585" "False" "High" "IsMasterProtein" "P61006" "Ras-related protein Rab-8A OS=Homo sapiens OX=9606 GN=RAB8A PE=1 SV=1" "0.000" "False" "28.822" "24" "5" "36" "1" "207" "23.7" "9.07" "95.23" "5" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "4218" "ENSG00000167461" "RAB8A" "B4DEK7; hsa:4218; P24407; P61006; Q6FHV5" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape; Joubert syndrome" "Regulation of PLK1 Activity at G2/M Transition; Anchoring of the basal body to the plasma membrane; RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; VxPx cargo-targeting to cilium; TBC/RABGAPs" "10" "0" "0.951" "1.067" "0.974" "0.737" "0.913" "1.021" "1.068" "1.019" "0.523" "101.9" "96.9" "108.8" "99.3" "75.1" "93.1" "104.0" "108.9" "103.9" "53.3" "" "" "" "" "" "" "" "" "" "" "61.0" "50.4" "60.2" "46.6" "34.8" "47.7" "48.4" "48.9" "56.4" "53.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3301543360737881129" "False" "High" "IsMasterProtein" "Q9Y281" "Cofilin-2 OS=Homo sapiens OX=9606 GN=CFL2 PE=1 SV=1" "0.000" "False" "28.822" "43" "6" "33" "3" "166" "18.7" "7.88" "67.65" "6" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00241" "1073" "ENSG00000165410" "CFL2" "G3V5P4; hsa:1073; Q9Y281" "Leptin signaling pathway; Microtubule cytoskeleton regulation; Regulation of actin cytoskeleton; G13 signaling pathway" "" "4" "0" "1.191" "1.087" "1.253" "0.841" "0.916" "0.967" "1.002" "0.940" "0.680" "119.2" "141.9" "129.6" "149.3" "100.2" "109.1" "115.2" "119.4" "112.1" "81.0" "" "" "" "" "" "" "" "" "" "" "71.3" "73.7" "71.8" "70.1" "46.4" "55.9" "53.6" "53.6" "60.8" "81.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5857660237806613264" "False" "High" "IsMasterProtein" "Q9NXV6" "CDKN2A-interacting protein OS=Homo sapiens OX=9606 GN=CDKN2AIP PE=1 SV=3" "0.000" "False" "28.815" "21" "10" "12" "10" "580" "61.1" "9.01" "20.52" "10" "stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf11952" "55602" "ENSG00000168564" "CDKN2AIP" "hsa:55602; Q8TBM5; Q9NXV6; Q9NYH0" "" "" "0" "0" "1.067" "1.069" "0.960" "1.013" "0.992" "1.002" "1.058" "1.121" "1.838" "220.1" "234.9" "235.1" "211.2" "222.9" "218.3" "220.6" "232.8" "246.7" "404.4" "" "" "" "" "" "" "" "" "" "" "131.7" "122.1" "130.2" "99.1" "103.3" "111.8" "102.6" "104.5" "133.9" "404.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2260293505055803748" "False" "High" "IsMasterProtein" "Q5JSZ5" "Protein PRRC2B OS=Homo sapiens OX=9606 GN=PRRC2B PE=1 SV=2" "0.000" "False" "28.807" "4" "7" "8" "7" "2229" "242.8" "8.34" "22.61" "7" "other biological processes" "" "" "Pf07001" "84726" "ENSG00000288701" "PRRC2B" "hsa:84726; O60270; Q5JSZ5; Q5JSZ7; Q66VZ2; Q68CR0; Q96EI9; Q9H683" "" "" "0" "0" "1.058" "1.044" "1.065" "0.903" "1.029" "0.880" "1.122" "0.958" "0.488" "460.7" "487.3" "480.9" "490.8" "416.0" "474.1" "405.5" "516.9" "441.6" "225.1" "" "" "" "" "" "" "" "" "" "" "275.7" "253.2" "266.3" "230.4" "192.8" "242.7" "188.5" "232.1" "239.6" "225.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1535897714363242613" "False" "High" "IsMasterProtein" "Q15019" "Septin-2 OS=Homo sapiens OX=9606 GN=SEPTIN2 PE=1 SV=1" "0.000" "False" "28.793" "23" "8" "31" "8" "361" "41.5" "6.60" "66.24" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00735" "4735" "ENSG00000168385" "SEPTIN2" "B4DGE8; hsa:4735; Q14132; Q15019; Q53QU3; Q8IUK9; Q96CB0" "2q37 copy number variation syndrome" "Anchoring of the basal body to the plasma membrane" "2" "0" "0.969" "0.995" "0.997" "1.025" "0.960" "1.042" "1.015" "1.065" "0.629" "789.7" "765.4" "786.1" "787.2" "809.4" "757.8" "823.1" "801.7" "841.2" "496.5" "" "" "" "" "" "" "" "" "" "" "472.6" "397.8" "435.3" "369.6" "375.2" "387.9" "382.7" "359.9" "456.4" "496.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2084755087725056383" "False" "High" "IsMasterProtein" "P05023" "Sodium/potassium-transporting ATPase subunit alpha-1 OS=Homo sapiens OX=9606 GN=ATP1A1 PE=1 SV=1" "0.000" "False" "28.772" "9" "9" "11" "9" "1023" "112.8" "5.49" "29.10" "9" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf00122, Pf00689, Pf00690, Pf13246" "476" "ENSG00000163399" "ATP1A1" "B2RBR6; B7Z2T5; B7Z3U6; F5H3A1; hsa:476; P05023; Q16689; Q6LDM4; Q9UCN1; Q9UJ20; Q9UJ21" "Pre-implantation embryo; Proximal tubule transport; Arsenic metabolism and reactive oxygen species generation" "Potential therapeutics for SARS; Ion homeostasis; Ion transport by P-type ATPases" "6" "0" "1.148" "1.118" "0.967" "1.106" "1.087" "1.078" "1.309" "1.406" "0.527" "284.8" "326.9" "318.5" "275.4" "315.0" "309.6" "307.1" "372.7" "400.4" "150.0" "" "" "" "" "" "" "" "" "" "" "170.4" "169.9" "176.4" "129.3" "146.0" "158.5" "142.8" "167.3" "217.2" "150.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2836831182499166141" "False" "High" "IsMasterProtein" "O00148" "ATP-dependent RNA helicase DDX39A OS=Homo sapiens OX=9606 GN=DDX39A PE=1 SV=2" "0.000" "False" "28.762" "19" "9" "30" "1" "427" "49.1" "5.68" "61.60" "9" "RNA metabolism OR transcription;other metabolic processes;transport" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271" "10212" "ENSG00000123136" "DDX39A" "B1Q2N1; hsa:10212; O00148; Q8N5M0; Q9BVP6; Q9H5W0" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "0.927" "1.098" "1.046" "0.944" "1.325" "0.742" "0.936" "0.702" "3.034" "37.7" "35.0" "41.4" "39.4" "35.6" "49.9" "28.0" "35.3" "26.4" "114.3" "" "" "" "" "" "" "" "" "" "" "22.6" "18.2" "22.9" "18.5" "16.5" "25.6" "13.0" "15.8" "14.3" "114.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1079834079423301401" "False" "High" "IsMasterProtein" "Q8TD19" "Serine/threonine-protein kinase Nek9 OS=Homo sapiens OX=9606 GN=NEK9 PE=1 SV=2" "0.000" "False" "28.750" "6" "5" "8" "5" "979" "107.1" "5.74" "25.91" "5" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00415, Pf13540" "91754" "ENSG00000119638" "NEK9" "hsa:91754; Q52LK6; Q8NCN0; Q8TCY4; Q8TD19; Q9UPI4; Q9Y6S4; Q9Y6S5; Q9Y6S6" "Ciliopathies" "EML4 and NUDC in mitotic spindle formation; Nuclear Pore Complex (NPC) Disassembly; Activation of NIMA Kinases NEK9, NEK6, NEK7" "4" "0" "1.026" "1.024" "1.121" "1.008" "0.993" "1.068" "1.027" "1.005" "1.135" "479.1" "491.5" "490.9" "536.9" "483.0" "475.6" "511.8" "491.9" "481.3" "543.8" "" "" "" "" "" "" "" "" "" "" "286.7" "255.4" "271.8" "252.1" "223.9" "243.5" "238.0" "220.9" "261.1" "543.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-662139928789152118" "False" "High" "IsMasterProtein" "Q8WYJ6" "Septin-1 OS=Homo sapiens OX=9606 GN=SEPTIN1 PE=1 SV=3" "0.000" "False" "28.693" "25" "8" "13" "8" "372" "42.4" "5.80" "37.63" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "1731" "ENSG00000180096" "SEPTIN1" "B4DVE6; hsa:1731; Q658T1; Q8NEZ1; Q8WYJ6; Q96EL4; Q9H285" "" "" "0" "0" "0.906" "0.941" "1.072" "1.076" "0.950" "0.936" "0.996" "0.889" "0.815" "579.6" "525.3" "545.2" "621.4" "623.7" "550.5" "542.4" "577.2" "515.3" "472.3" "" "" "" "" "" "" "" "" "" "" "346.8" "273.0" "301.9" "291.8" "289.1" "281.8" "252.2" "259.1" "279.6" "472.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8166763961734876416" "False" "High" "IsMasterProtein" "P54727" "UV excision repair protein RAD23 homolog B OS=Homo sapiens OX=9606 GN=RAD23B PE=1 SV=1" "0.000" "False" "28.686" "16" "7" "28" "6" "409" "43.1" "4.84" "57.28" "7" "protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00627, Pf09280" "5887" "ENSG00000119318" "RAD23B" "B3KWK8; G5E9P0; hsa:5887; P54727; Q7Z5K8; Q8WUB0" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; HDAC6 interactions in the central nervous system" "Formation of Incision Complex in GG-NER; Josephin domain DUBs; DNA Damage Recognition in GG-NER; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "8" "1" "0.958" "0.933" "0.984" "1.049" "0.967" "1.055" "1.003" "0.963" "0.554" "2426.1" "2324.2" "2262.9" "2386.6" "2544.6" "2346.9" "2558.4" "2433.6" "2337.3" "1344.2" "" "" "" "" "" "" "" "" "" "" "1451.9" "1207.8" "1253.1" "1120.4" "1179.5" "1201.5" "1189.6" "1092.5" "1268.1" "1344.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9177231757861531522" "False" "High" "IsMasterProtein" "P25685" "DnaJ homolog subfamily B member 1 OS=Homo sapiens OX=9606 GN=DNAJB1 PE=1 SV=4" "0.000" "False" "28.674" "25" "9" "13" "9" "340" "38.0" "8.63" "30.93" "9" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00226, Pf01556" "3337" "ENSG00000132002" "DNAJB1" "B4DX52; hsa:3337; P25685" "Nuclear receptors meta-pathway; NRF2 pathway" "MAPK6/MAPK4 signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Regulation of HSF1-mediated heat shock response; Attenuation phase" "7" "0" "1.037" "1.047" "1.083" "1.224" "1.036" "1.052" "0.851" "1.134" "4.572" "310.6" "322.0" "325.3" "336.5" "380.1" "321.7" "326.7" "264.4" "352.2" "1420.0" "" "" "" "" "" "" "" "" "" "" "185.9" "167.3" "180.1" "158.0" "176.2" "164.7" "151.9" "118.7" "191.1" "1420.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4697370261215889932" "False" "High" "IsMasterProtein" "O43583" "Density-regulated protein OS=Homo sapiens OX=9606 GN=DENR PE=1 SV=2" "0.000" "False" "28.621" "29" "5" "16" "5" "198" "22.1" "5.30" "46.61" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "nucleic acid binding activity" "Pf01253, Pf21023" "8562" "ENSG00000139726" "DENR" "hsa:8562; O43583; Q9H3U6; Q9UKZ0" "" "" "0" "0" "1.037" "0.984" "0.968" "1.037" "0.981" "1.091" "1.059" "1.008" "0.425" "1667.6" "1729.3" "1640.6" "1613.6" "1729.4" "1636.7" "1819.7" "1765.6" "1681.7" "708.8" "" "" "" "" "" "" "" "" "" "" "998.0" "898.6" "908.5" "757.5" "801.6" "837.9" "846.1" "792.7" "912.4" "708.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1871609499973025843" "False" "High" "IsMasterProtein" "Q07021" "Complement component 1 Q subcomponent-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=C1QBP PE=1 SV=1" "0.000" "False" "28.598" "16" "3" "12" "3" "282" "31.3" "4.84" "28.20" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;translation activity;nucleic acid binding activity;other molecular function" "Pf02330" "708" "ENSG00000108561" "C1QBP" "hsa:708; Q07021; Q2HXR8; Q9NNY8" "Complement system; Mesodermal commitment pathway; Ebola virus infection in host" "RHOC GTPase cycle; RHOA GTPase cycle; Intrinsic Pathway of Fibrin Clot Formation; Apoptotic factor-mediated response; Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function" "8" "0" "1.015" "1.056" "0.971" "1.039" "1.025" "1.074" "1.009" "1.073" "1.931" "409.4" "415.6" "432.3" "397.7" "425.2" "419.5" "439.5" "413.0" "439.4" "790.7" "" "" "" "" "" "" "" "" "" "" "245.0" "216.0" "239.4" "186.7" "197.1" "214.7" "204.4" "185.4" "238.4" "790.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6210925912035566058" "False" "High" "IsMasterProtein" "Q14980" "Nuclear mitotic apparatus protein 1 OS=Homo sapiens OX=9606 GN=NUMA1 PE=1 SV=2" "0.000" "False" "28.573" "5" "8" "10" "8" "2115" "238.1" "5.78" "21.58" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf21670" "4926" "ENSG00000137497" "NUMA1" "H0YH75; hsa:4926; Q14980; Q14981; Q9BTE9" "Ectoderm differentiation; Ectoderm differentiation; 8p23.1 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Mitotic Prophase" "5" "0" "0.826" "0.876" "0.756" "1.078" "0.713" "0.985" "0.661" "0.888" "2.720" "40.8" "33.7" "35.7" "30.9" "44.0" "29.1" "40.2" "27.0" "36.2" "111.0" "" "" "" "" "" "" "" "" "" "" "24.4" "17.5" "19.8" "14.5" "20.4" "14.9" "18.7" "12.1" "19.7" "111.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1535429357355427418" "False" "High" "IsMasterProtein" "Q9UL25" "Ras-related protein Rab-21 OS=Homo sapiens OX=9606 GN=RAB21 PE=1 SV=3" "0.000" "False" "28.566" "20" "4" "13" "4" "225" "24.3" "7.94" "39.87" "4" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "23011" "ENSG00000080371" "RAB21" "hsa:23011; Q14466; Q569H3; Q9UL25" "Ciliary landscape" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation" "3" "0" "1.026" "0.936" "1.110" "1.044" "1.144" "0.993" "1.103" "0.992" "0.658" "607.3" "623.1" "568.5" "674.1" "634.3" "694.8" "603.0" "670.1" "602.4" "399.4" "" "" "" "" "" "" "" "" "" "" "363.4" "323.8" "314.8" "316.5" "294.0" "355.7" "280.4" "300.9" "326.8" "399.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1047543099056468626" "False" "High" "IsMasterProtein" "P09104" "Gamma-enolase OS=Homo sapiens OX=9606 GN=ENO2 PE=1 SV=3" "0.000" "False" "28.551" "17" "6" "16" "4" "434" "47.2" "5.03" "40.34" "6" "other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00113, Pf03952" "2026" "ENSG00000111674" "ENO2" "B7Z2X9; hsa:2026; P09104; Q96J33" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis" "5" "1" "1.103" "0.994" "1.049" "0.979" "0.795" "1.150" "0.913" "1.140" "0.873" "421.2" "464.8" "418.5" "441.7" "412.5" "334.8" "484.3" "384.7" "480.1" "367.7" "" "" "" "" "" "" "" "" "" "" "252.1" "241.5" "231.8" "207.4" "191.2" "171.4" "225.2" "172.7" "260.5" "367.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1633285367868477603" "False" "High" "IsMasterProtein" "P35241" "Radixin OS=Homo sapiens OX=9606 GN=RDX PE=1 SV=1" "0.000" "False" "28.508" "12" "9" "26" "1" "583" "68.5" "6.37" "70.81" "9" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "5962" "ENSG00000137710" "RDX" "A7YIJ8; A7YIK0; A7YIK3; B7Z9U6; F5H1A7; hsa:5962; P35241; Q86Y61" "Regulation of actin cytoskeleton" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4307491490075501206" "False" "High" "IsMasterProtein" "P32322" "Pyrroline-5-carboxylate reductase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PYCR1 PE=1 SV=2" "0.000" "False" "28.403" "27" "6" "11" "5" "319" "33.3" "7.61" "29.70" "6" "other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf03807, Pf14748" "5831" "ENSG00000183010" "PYCR1" "A6NFM2; B4DMU0; hsa:5831; P32322; Q6FHI4; Q96DI6; Q9HBQ4" "Amino acid metabolism; Metabolic reprogramming in colon cancer" "Glutamate and glutamine metabolism" "3" "1" "0.952" "0.918" "1.117" "1.094" "1.073" "0.997" "0.893" "1.043" "0.796" "276.4" "263.1" "253.6" "308.8" "302.3" "296.4" "275.6" "246.9" "288.1" "219.9" "" "" "" "" "" "" "" "" "" "" "165.4" "136.7" "140.4" "145.0" "140.1" "151.8" "128.1" "110.8" "156.3" "219.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3313635736816900772" "False" "High" "IsMasterProtein" "O96019" "Actin-like protein 6A OS=Homo sapiens OX=9606 GN=ACTL6A PE=1 SV=1" "0.000" "False" "28.401" "22" "8" "12" "8" "429" "47.4" "5.60" "23.56" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00022" "86" "ENSG00000136518" "ACTL6A" "B3KMN1; D3DNR9; hsa:86; O96019; Q8TAE5; Q9BVS8; Q9H0W6" "Androgen receptor network in prostate cancer; Gastric cancer network 1; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RMTs methylate histone arginines; UCH proteinases; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; HATs acetylate histones; DNA Damage Recognition in GG-NER" "10" "0" "1.083" "1.123" "0.974" "1.098" "1.111" "0.992" "0.905" "0.989" "2.713" "263.5" "285.3" "295.8" "256.6" "289.2" "292.7" "261.4" "238.5" "260.7" "714.9" "" "" "" "" "" "" "" "" "" "" "157.7" "148.3" "163.8" "120.5" "134.1" "149.8" "121.5" "107.1" "141.4" "714.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7874915043186486884" "False" "High" "IsMasterProtein" "P20962" "Parathymosin OS=Homo sapiens OX=9606 GN=PTMS PE=1 SV=2" "0.000" "False" "28.351" "24" "4" "7" "4" "102" "11.5" "4.16" "23.63" "4" "DNA metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf03247" "5763" "ENSG00000159335" "PTMS" "hsa:5763; P20962" "IL-18 signaling pathway" "" "1" "0" "0.950" "0.955" "0.919" "0.992" "0.954" "0.956" "1.110" "0.788" "0.361" "1007.2" "956.6" "962.2" "925.9" "999.2" "961.0" "962.5" "1118.4" "794.1" "363.8" "" "" "" "" "" "" "" "" "" "" "602.7" "497.1" "532.8" "434.7" "463.1" "492.0" "447.5" "502.1" "430.8" "363.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3028691531671689044" "False" "High" "IsMasterProtein" "Q14697" "Neutral alpha-glucosidase AB OS=Homo sapiens OX=9606 GN=GANAB PE=1 SV=3" "0.000" "False" "28.291" "11" "10" "21" "10" "944" "106.8" "6.14" "53.68" "10" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf01055, Pf13802, Pf21365" "23193" "ENSG00000089597" "GANAB" "A6NC20; hsa:23193; Q14697; Q8WTS9; Q9P0X0" "N-glycan biosynthesis" "Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "5" "0" "1.091" "1.032" "1.179" "1.281" "1.158" "1.114" "0.773" "1.163" "5.108" "470.6" "513.6" "485.7" "554.7" "602.7" "545.1" "524.3" "363.8" "547.2" "2403.8" "" "" "" "" "" "" "" "" "" "" "281.6" "266.9" "269.0" "260.4" "279.3" "279.1" "243.8" "163.3" "296.9" "2403.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8827666052570193854" "False" "High" "IsMasterProtein" "Q15056" "Eukaryotic translation initiation factor 4H OS=Homo sapiens OX=9606 GN=EIF4H PE=1 SV=5" "0.000" "False" "28.242" "27" "8" "20" "8" "248" "27.4" "7.23" "52.41" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00076" "7458" "ENSG00000106682" "EIF4H" "A8K3R1; D3DXF6; D3DXF8; hsa:7458; Q15056" "Translation factors; 7q11.23 copy number variation syndrome" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Ribosomal scanning and start codon recognition" "7" "0" "1.145" "1.196" "1.231" "1.019" "0.935" "0.944" "1.012" "0.952" "1.044" "1077.5" "1233.4" "1288.6" "1325.9" "1097.8" "1007.4" "1016.7" "1090.9" "1025.9" "1124.9" "" "" "" "" "" "" "" "" "" "" "644.8" "640.9" "713.6" "622.5" "508.8" "515.7" "472.7" "489.7" "556.6" "1124.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "144982604897555779" "False" "High" "IsMasterProtein" "P52306" "Rap1 GTPase-GDP dissociation stimulator 1 OS=Homo sapiens OX=9606 GN=RAP1GDS1 PE=1 SV=3" "0.000" "False" "28.240" "13" "8" "11" "8" "607" "66.3" "5.31" "25.54" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;ER/Golgi;nucleus" "enzyme regulator activity" "Pf00514" "5910" "ENSG00000138698" "RAP1GDS1" "E9PH06; G5E9P9; hsa:5910; P52306; Q499L7; Q4KMV2; Q4QQI8; Q9BUW9; Q9BUX6; Q9NYM2; Q9NZA8" "" "RHOT2 GTPase cycle; RHOT1 GTPase cycle" "2" "0" "1.201" "1.549" "1.204" "1.156" "1.184" "1.098" "0.742" "1.160" "6.144" "200.9" "241.3" "311.2" "242.0" "232.2" "237.9" "220.7" "149.0" "233.1" "1234.4" "" "" "" "" "" "" "" "" "" "" "120.2" "125.4" "172.3" "113.6" "107.6" "121.8" "102.6" "66.9" "126.4" "1234.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6585678134614880292" "False" "High" "IsMasterProtein" "Q9NTK5" "Obg-like ATPase 1 OS=Homo sapiens OX=9606 GN=OLA1 PE=1 SV=2" "0.000" "False" "28.206" "19" "8" "13" "8" "396" "44.7" "7.81" "39.80" "8" "other metabolic processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "translation activity;other molecular function" "Pf01926, Pf06071" "29789" "ENSG00000138430" "OLA1" "D7EHM2; hsa:29789; Q5BJD7; Q8NCI8; Q96CU1; Q96SV2; Q9NTK5; Q9P1D3; Q9UNY9; Q9Y6G4" "" "Platelet degranulation" "1" "0" "1.125" "0.970" "1.182" "1.063" "1.113" "1.100" "1.129" "1.061" "1.339" "1260.7" "1417.9" "1222.6" "1489.5" "1340.3" "1402.6" "1386.2" "1422.8" "1337.0" "1688.5" "" "" "" "" "" "" "" "" "" "" "754.4" "736.8" "677.0" "699.3" "621.2" "718.0" "644.6" "638.8" "725.4" "1688.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "868843744032576337" "False" "High" "IsMasterProtein" "P48444" "Coatomer subunit delta OS=Homo sapiens OX=9606 GN=ARCN1 PE=1 SV=1" "0.000" "False" "28.151" "19" "9" "11" "9" "511" "57.2" "6.21" "22.87" "9" "transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf00928, Pf01217" "372" "ENSG00000095139" "ARCN1" "B4E1X2; E9PEU4; hsa:372; P48444; Q52M80" "miR-517 relationship with ARCN1 and USP1" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic" "3" "0" "1.088" "1.107" "1.200" "1.183" "1.327" "1.170" "1.052" "1.133" "2.035" "399.2" "434.2" "442.0" "479.2" "472.4" "529.6" "467.0" "420.0" "452.3" "812.5" "" "" "" "" "" "" "" "" "" "" "238.9" "225.7" "244.8" "225.0" "219.0" "271.1" "217.2" "188.5" "245.4" "812.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "636260914267966179" "False" "High" "IsMasterProtein" "Q6YP21" "Kynurenine--oxoglutarate transaminase 3 OS=Homo sapiens OX=9606 GN=KYAT3 PE=1 SV=1" "0.000" "False" "28.073" "14" "6" "18" "5" "454" "51.4" "8.19" "47.97" "6" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00155" "56267" "ENSG00000137944" "KYAT3" "B3KQ13; hsa:56267; O95335; Q5JS27; Q5T9T7; Q5T9T8; Q6AI27; Q6ICW1; Q6YP21; Q9BVY5" "Tryptophan metabolism" "Tryptophan catabolism" "2" "1" "1.091" "0.975" "1.010" "0.979" "1.140" "1.033" "1.133" "1.020" "0.703" "678.4" "740.3" "661.4" "685.1" "664.5" "773.4" "700.7" "768.5" "692.0" "477.2" "" "" "" "" "" "" "" "" "" "" "406.0" "384.7" "366.3" "321.6" "308.0" "395.9" "325.8" "345.0" "375.4" "477.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-985965989456980911" "False" "High" "IsMasterProtein" "Q8TEQ6" "Gem-associated protein 5 OS=Homo sapiens OX=9606 GN=GEMIN5 PE=1 SV=3" "0.000" "False" "28.004" "7" "10" "11" "10" "1508" "168.5" "6.62" "21.99" "10" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf00400, Pf12894, Pf21720" "25929" "ENSG00000082516" "GEMIN5" "Q14CV0; Q8TEQ6; Q8WWV4; Q969W4; Q9H9K3; Q9UFI5" "" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "2" "0" "1.056" "0.956" "1.186" "1.094" "1.319" "1.152" "1.010" "1.133" "5.029" "115.2" "121.6" "110.1" "136.6" "126.0" "151.9" "132.7" "116.3" "130.5" "579.1" "" "" "" "" "" "" "" "" "" "" "68.9" "63.2" "61.0" "64.1" "58.4" "77.8" "61.7" "52.2" "70.8" "579.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5198752139468277763" "False" "High" "IsMasterProtein" "Q96PK6" "RNA-binding protein 14 OS=Homo sapiens OX=9606 GN=RBM14 PE=1 SV=2" "0.000" "False" "27.974" "12" "7" "15" "7" "669" "69.4" "9.67" "33.29" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00076" "100526737; 10432" "ENSG00000239306" "RBM14" "B0LM41; B3KMN4; D6RGD8; hsa:100526737; hsa:10432; O75932; Q2PYN1; Q53GV1; Q68DQ9; Q96PK5; Q96PK6" "Ciliary landscape" "RUNX2 regulates bone development" "2" "0" "1.024" "1.103" "1.313" "1.192" "1.187" "1.362" "0.860" "1.132" "3.927" "294.5" "301.7" "324.8" "386.8" "351.2" "349.7" "401.2" "253.4" "333.4" "1156.7" "" "" "" "" "" "" "" "" "" "" "176.3" "156.8" "179.9" "181.6" "162.8" "179.0" "186.6" "113.8" "180.9" "1156.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6941898924238947203" "False" "High" "IsMasterProtein" "P52565" "Rho GDP-dissociation inhibitor 1 OS=Homo sapiens OX=9606 GN=ARHGDIA PE=1 SV=3" "0.000" "False" "27.904" "23" "6" "13" "6" "204" "23.2" "5.11" "25.55" "6" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf02115" "396" "ENSG00000141522" "ARHGDIA" "A8MXW0; B2R5X1; B4DDD3; B4DUV9; hsa:396; P52565; Q6IBM5" "Ciliary landscape; Nephrotic syndrome; Vasopressin-regulated water reabsorption" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOH GTPase cycle; Axonal growth stimulation; Axonal growth inhibition (RHOA activation)" "12" "0" "1.343" "1.496" "1.226" "1.336" "1.260" "1.305" "1.269" "1.323" "1.517" "423.9" "569.5" "634.1" "519.8" "566.3" "534.3" "553.1" "537.8" "560.7" "642.8" "" "" "" "" "" "" "" "" "" "" "253.7" "295.9" "351.1" "244.0" "262.5" "273.5" "257.2" "241.5" "304.2" "642.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7326537803977903766" "False" "High" "IsMasterProtein" "P02786" "Transferrin receptor protein 1 OS=Homo sapiens OX=9606 GN=TFRC PE=1 SV=2" "0.000" "False" "27.880" "10" "8" "19" "8" "760" "84.8" "6.61" "49.29" "8" "stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf02225, Pf04253, Pf04389" "7037" "ENSG00000072274" "TFRC" "D3DXB0; hsa:7037; P02786; Q1HE24; Q59G55; Q9UCN0; Q9UCU5; Q9UDF9; Q9UK21" "Iron metabolism in placenta; Ferroptosis; 3q29 copy number variation syndrome; Iron metabolism disorders" "RHOC GTPase cycle; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; Golgi Associated Vesicle Biogenesis; RND1 GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; Transferrin endocytosis and recycling; RHOH GTPase cycle" "21" "0" "1.082" "1.142" "1.133" "1.067" "1.096" "1.067" "1.153" "1.067" "0.998" "529.5" "572.9" "604.8" "600.0" "565.1" "580.4" "565.1" "610.5" "565.2" "528.3" "" "" "" "" "" "" "" "" "" "" "316.9" "297.7" "334.9" "281.7" "261.9" "297.1" "262.8" "274.1" "306.6" "528.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6856624260157841827" "False" "High" "IsMasterProtein" "O60256" "Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Homo sapiens OX=9606 GN=PRPSAP2 PE=1 SV=1" "0.000" "False" "27.854" "21" "6" "23" "6" "369" "40.9" "7.44" "45.48" "6" "other metabolic processes;developmental processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf13793, Pf14572" "5636" "ENSG00000141127" "PRPSAP2" "B4E1M8; B4E329; B7ZKZ1; E7EMY2; hsa:5636; O60256; Q6IAS2" "" "" "0" "0" "0.969" "0.992" "1.033" "0.857" "1.031" "0.904" "1.009" "0.903" "0.648" "496.3" "481.0" "492.3" "512.4" "425.5" "511.8" "448.6" "500.7" "448.2" "321.5" "" "" "" "" "" "" "" "" "" "" "297.0" "250.0" "272.6" "240.6" "197.2" "262.0" "208.6" "224.8" "243.2" "321.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1757040485264551221" "False" "High" "IsMasterProtein" "Q9Y6A5" "Transforming acidic coiled-coil-containing protein 3 OS=Homo sapiens OX=9606 GN=TACC3 PE=1 SV=1" "0.000" "False" "27.845" "10" "8" "11" "8" "838" "90.3" "5.05" "23.76" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf05010" "10460" "ENSG00000013810" "TACC3" "hsa:10460; Q2NKK4; Q3KQS5; Q9UMQ1; Q9Y6A5" "4p16.3 copy number variation" "Negative regulation of NOTCH4 signaling; NOTCH3 Activation and Transmission of Signal to the Nucleus" "3" "0" "1.161" "0.996" "1.014" "1.153" "1.051" "1.197" "1.302" "1.234" "0.758" "474.0" "550.3" "471.9" "480.9" "546.5" "498.4" "567.3" "617.1" "585.1" "359.1" "" "" "" "" "" "" "" "" "" "" "283.7" "285.9" "261.3" "225.8" "253.3" "255.1" "263.8" "277.0" "317.4" "359.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9080862626962095597" "False" "High" "IsMasterProtein" "O75312" "Zinc finger protein ZPR1 OS=Homo sapiens OX=9606 GN=ZPR1 PE=1 SV=1" "0.000" "False" "27.826" "17" "7" "10" "7" "459" "50.9" "4.73" "27.91" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf03367" "8882" "ENSG00000109917" "ZPR1" "hsa:8882; O75312; Q2TAA0" "" "" "0" "0" "1.202" "0.992" "1.068" "1.181" "1.037" "1.208" "1.010" "1.166" "1.352" "295.0" "354.7" "292.6" "315.0" "348.3" "305.7" "356.2" "298.0" "343.9" "398.8" "" "" "" "" "" "" "" "" "" "" "176.5" "184.3" "162.1" "147.9" "161.4" "156.5" "165.6" "133.8" "186.6" "398.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8648350258145669710" "False" "High" "IsMasterProtein" "Q15717" "ELAV-like protein 1 OS=Homo sapiens OX=9606 GN=ELAVL1 PE=1 SV=2" "0.000" "False" "27.798" "23" "6" "11" "6" "326" "36.1" "9.17" "32.33" "6" "cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "1994" "ENSG00000066044" "ELAVL1" "B4DVB8; hsa:1994; Q15717; Q53XN6; Q9BTT1" "AMP-activated protein kinase signaling; Endoderm differentiation; Pre-implantation embryo; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Gastrin signaling pathway; IL-18 signaling pathway; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; 1p36 copy number variation syndrome" "HuR (ELAVL1) binds and stabilizes mRNA" "10" "0" "1.099" "1.044" "1.163" "1.129" "1.053" "1.155" "0.400" "1.004" "8.385" "168.4" "185.1" "175.8" "195.9" "190.1" "177.4" "194.6" "67.4" "169.1" "1412.4" "" "" "" "" "" "" "" "" "" "" "100.8" "96.2" "97.4" "92.0" "88.1" "90.8" "90.5" "30.2" "91.7" "1412.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9091705123101461009" "False" "High" "IsMasterProtein" "P99999" "Cytochrome c OS=Homo sapiens OX=9606 GN=CYCS PE=1 SV=2" "0.000" "False" "27.790" "31" "3" "39" "3" "105" "11.7" "9.57" "106.47" "3" "other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00034" "54205" "ENSG00000172115" "CYCS" "A4D166; B2R4I1; hsa:54205; P00001; P99999; Q6NUR2; Q6NX69; Q96BV4" "miRNA regulation of DNA damage response; Apoptosis modulation and signaling; Alzheimer's disease and miRNA effects; AGE/RAGE pathway; Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling; Oxidative damage response; NO/cGMP/PKG mediated neuroprotection; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Pleural mesothelioma; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response" "Respiratory electron transport; Detoxification of Reactive Oxygen Species; Transcriptional activation of mitochondrial biogenesis; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria; Pyroptosis" "36" "0" "0.849" "0.948" "0.850" "0.894" "0.909" "0.895" "0.933" "0.819" "0.480" "2751.9" "2336.9" "2609.1" "2339.8" "2460.7" "2500.5" "2463.7" "2567.6" "2255.1" "1322.3" "" "" "" "" "" "" "" "" "" "" "1646.9" "1214.4" "1444.9" "1098.5" "1140.6" "1280.1" "1145.6" "1152.7" "1223.5" "1322.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5190108194104216904" "False" "High" "IsMasterProtein" "O43615" "Mitochondrial import inner membrane translocase subunit TIM44 OS=Homo sapiens OX=9606 GN=TIMM44 PE=1 SV=2" "0.000" "False" "27.790" "18" "9" "11" "9" "452" "51.3" "8.32" "27.74" "9" "transport;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf04280" "10469" "ENSG00000104980" "TIMM44" "A8K0R9; D6W664; hsa:10469; O43615; Q8N193" "" "Mitochondrial protein import" "1" "0" "0.925" "0.878" "0.924" "1.051" "0.868" "1.137" "0.834" "0.939" "1.734" "474.6" "439.1" "416.9" "438.4" "498.7" "411.7" "539.7" "396.0" "445.8" "822.7" "" "" "" "" "" "" "" "" "" "" "284.0" "228.2" "230.9" "205.8" "231.2" "210.8" "250.9" "177.8" "241.9" "822.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4480157126328656163" "False" "High" "IsMasterProtein" "O75937" "DnaJ homolog subfamily C member 8 OS=Homo sapiens OX=9606 GN=DNAJC8 PE=1 SV=2" "0.000" "False" "27.744" "23" "7" "16" "7" "253" "29.8" "9.06" "39.58" "7" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf00226" "22826" "ENSG00000126698" "DNAJC8" "B4DUU4; D3DPM0; hsa:22826; O75937; Q6IBA4; Q8N4Z5; Q9P051; Q9P067" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.039" "1.106" "1.017" "1.045" "0.938" "1.073" "0.999" "1.058" "1.313" "1546.5" "1606.9" "1710.3" "1573.1" "1615.3" "1450.2" "1659.3" "1544.6" "1636.3" "2030.9" "" "" "" "" "" "" "" "" "" "" "925.5" "835.0" "947.1" "738.5" "748.7" "742.4" "771.6" "693.4" "887.8" "2030.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8802670806529502835" "False" "High" "IsMasterProtein" "Q6NYC8" "Phostensin OS=Homo sapiens OX=9606 GN=PPP1R18 PE=1 SV=1" "0.000" "False" "27.729" "12" "6" "6" "6" "613" "67.9" "5.40" "21.06" "6" "" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf13914, Pf13916" "170954" "ENSG00000146112; ENSG00000206485; ENSG00000225060; ENSG00000229998; ENSG00000230341; ENSG00000234000" "PPP1R18" "A2AB01; A2AIB8; A4UBI6; A6NCB7; A8MSS7; B7ZCV7; hsa:170954; Q68CK8; Q6NYC8; Q6ZTV1; Q6ZUJ6; Q8NDQ4; Q8TF52; Q9BRL9" "TYROBP causal network in microglia" "" "1" "0" "0.956" "0.994" "1.007" "0.947" "0.848" "1.081" "1.019" "1.042" "0.894" "342.5" "327.5" "340.5" "345.1" "324.2" "290.4" "370.3" "349.0" "357.0" "306.2" "" "" "" "" "" "" "" "" "" "" "205.0" "170.2" "188.6" "162.0" "150.3" "148.7" "172.2" "156.7" "193.7" "306.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1288043512151873046" "False" "High" "IsMasterProtein" "Q8WU39" "Marginal zone B- and B1-cell-specific protein OS=Homo sapiens OX=9606 GN=MZB1 PE=1 SV=1" "0.000" "False" "27.695" "40" "5" "15" "5" "189" "20.7" "5.57" "37.28" "5" "cell organization and biogenesis;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "" "Pf11938" "51237" "ENSG00000170476" "MZB1" "D2IYS0; hsa:51237; Q7Z6N2; Q8WU39; Q96RL5; Q9P0T3" "" "" "0" "0" "1.093" "0.937" "0.856" "0.965" "0.849" "0.811" "0.782" "0.826" "0.551" "504.8" "552.0" "473.2" "432.0" "487.3" "428.4" "409.4" "395.0" "417.2" "277.9" "" "" "" "" "" "" "" "" "" "" "302.1" "286.8" "262.0" "202.8" "225.9" "219.3" "190.4" "177.3" "226.3" "277.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3010766793389346536" "False" "High" "IsMasterProtein" "P0DP25" "Calmodulin-3 OS=Homo sapiens OX=9606 GN=CALM3 PE=1 SV=1" "0.000" "False" "27.676" "43" "6" "65" "6" "149" "16.8" "4.22" "178.88" "6" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf13499" "801; 805; 808" "ENSG00000160014" "CALM3" "hsa:801; hsa:805; hsa:808; P02593; P0DP25; P62158; P70667; P99014; Q13942; Q53S29; Q61379; Q61380; Q96HK3" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Myometrial relaxation and contraction pathways; G protein signaling pathways; Ras signaling; Melanoma; Endochondral ossification; Endochondral ossification with skeletal dysplasias; CAMKK2 pathway; Glycogen synthesis and degradation; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; G13 signaling pathway; Calcium regulation in cardiac cells" "" "17" "0" "0.927" "0.911" "0.864" "0.950" "0.925" "0.968" "0.959" "0.867" "0.479" "5538.3" "5136.6" "5043.9" "4786.9" "5260.4" "5120.5" "5360.3" "5309.1" "4800.7" "2653.3" "" "" "" "" "" "" "" "" "" "" "3314.3" "2669.3" "2793.2" "2247.3" "2438.3" "2621.3" "2492.4" "2383.4" "2604.6" "2653.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7915311945115274700" "False" "High" "IsMasterProtein" "O15212" "Prefoldin subunit 6 OS=Homo sapiens OX=9606 GN=PFDN6 PE=1 SV=1" "0.000" "False" "27.638" "36" "6" "15" "6" "129" "14.6" "8.88" "43.08" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "10471" "ENSG00000204220; ENSG00000206283; ENSG00000224782; ENSG00000235692; ENSG00000237335" "PFDN6" "hsa:10471; O15212" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "0.944" "0.982" "0.911" "1.083" "1.034" "1.001" "0.999" "0.937" "0.602" "695.1" "656.5" "682.6" "633.5" "752.5" "718.9" "695.9" "694.4" "651.6" "418.6" "" "" "" "" "" "" "" "" "" "" "416.0" "341.1" "378.0" "297.4" "348.8" "368.0" "323.6" "311.7" "353.5" "418.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8980263924004467581" "False" "High" "IsMasterProtein" "P28340" "DNA polymerase delta catalytic subunit OS=Homo sapiens OX=9606 GN=POLD1 PE=1 SV=2" "0.000" "False" "27.614" "9" "11" "13" "11" "1107" "123.6" "7.03" "34.08" "11" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00136, Pf03104, Pf14260" "5424" "ENSG00000062822" "POLD1" "hsa:5424; P28340; Q8NER3; Q96H98" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Progeria-associated lipodystrophy; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Cytosolic iron-sulfur cluster assembly; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "27" "0" "1.014" "0.939" "1.033" "0.969" "1.010" "0.658" "0.631" "0.672" "1.552" "591.9" "600.3" "555.7" "611.5" "573.7" "597.5" "389.6" "373.6" "397.6" "918.5" "" "" "" "" "" "" "" "" "" "" "354.2" "312.0" "307.7" "287.1" "265.9" "305.9" "181.1" "167.7" "215.7" "918.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6816817128509432528" "False" "High" "IsMasterProtein" "P10155" "RNA-binding protein RO60 OS=Homo sapiens OX=9606 GN=RO60 PE=1 SV=2" "0.000" "False" "27.598" "14" "9" "15" "9" "538" "60.6" "8.03" "37.86" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05731" "6738" "ENSG00000116747" "RO60" "B2RBB9; hsa:6738; P10155; Q5LJ98; Q5LJ99; Q5LJA0; Q86WL3; Q86WL4; Q92787; Q9H1W6" "" "" "0" "0" "0.942" "0.938" "0.895" "0.881" "0.926" "0.945" "0.911" "0.963" "0.668" "1796.3" "1692.5" "1685.5" "1607.1" "1582.7" "1663.3" "1696.9" "1635.6" "1730.3" "1199.2" "" "" "" "" "" "" "" "" "" "" "1075.0" "879.5" "933.4" "754.5" "733.6" "851.5" "789.0" "734.3" "938.8" "1199.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4886602285452216196" "False" "High" "IsMasterProtein" "Q92696" "Geranylgeranyl transferase type-2 subunit alpha OS=Homo sapiens OX=9606 GN=RABGGTA PE=1 SV=2" "0.000" "False" "27.586" "18" "10" "14" "10" "567" "65.0" "5.67" "28.10" "10" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00560, Pf01239, Pf07711" "5875" "ENSG00000100949; ENSG00000285193" "RABGGTA" "A8K5N2; D3DS69; hsa:5875; Q92696" "" "RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "2" "0" "1.060" "1.038" "1.145" "1.099" "1.107" "1.188" "1.070" "1.112" "1.024" "401.3" "425.4" "416.8" "459.5" "441.2" "444.1" "476.9" "429.4" "446.2" "411.2" "" "" "" "" "" "" "" "" "" "" "240.2" "221.1" "230.8" "215.7" "204.5" "227.3" "221.7" "192.8" "242.1" "411.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491250249564736583" "False" "High" "IsMasterProtein" "P49902" "Cytosolic purine 5'-nucleotidase OS=Homo sapiens OX=9606 GN=NT5C2 PE=1 SV=1" "0.000" "False" "27.550" "14" "8" "21" "8" "561" "64.9" "6.14" "54.53" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf05761" "22978" "ENSG00000076685" "NT5C2" "B7Z382; D3DR91; hsa:22978; P49902; Q5JUV5" "" "Purine catabolism; Ribavirin ADME; Abacavir metabolism" "3" "0" "0.970" "0.928" "0.993" "0.898" "0.991" "0.959" "1.042" "0.984" "0.553" "1585.3" "1538.2" "1471.9" "1573.8" "1423.6" "1571.8" "1520.1" "1651.3" "1559.8" "876.7" "" "" "" "" "" "" "" "" "" "" "948.7" "799.3" "815.1" "738.8" "659.8" "804.6" "706.8" "741.3" "846.3" "876.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1188306556528865133" "False" "High" "IsMasterProtein" "Q15691" "Microtubule-associated protein RP/EB family member 1 OS=Homo sapiens OX=9606 GN=MAPRE1 PE=1 SV=3" "0.000" "False" "27.542" "23" "5" "14" "5" "268" "30.0" "5.14" "37.20" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf03271" "22919" "ENSG00000101367" "MAPRE1" "B2R6I7; E1P5M8; hsa:22919; Q15691; Q3KQS8" "Microtubule cytoskeleton regulation; HDAC6 interactions in the central nervous system" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; The role of GTSE1 in G2/M progression after G2 checkpoint; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "16" "0" "1.036" "1.353" "1.079" "1.262" "1.073" "1.079" "0.737" "1.070" "3.559" "619.5" "641.8" "838.1" "668.3" "782.1" "664.8" "668.4" "456.7" "662.9" "2204.6" "" "" "" "" "" "" "" "" "" "" "370.7" "333.5" "464.1" "313.8" "362.5" "340.3" "310.8" "205.1" "359.6" "2204.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "460406497697363824" "False" "High" "IsMasterProtein" "P61018" "Ras-related protein Rab-4B OS=Homo sapiens OX=9606 GN=RAB4B PE=1 SV=1" "0.000" "False" "27.513" "26" "5" "15" "2" "213" "23.6" "6.06" "40.54" "5" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "53916" "ENSG00000167578" "RAB4B" "hsa:53916; P22750; P61018; Q7Z514; Q9HBR6" "Intracellular trafficking proteins involved in CMT neuropathy" "RAB geranylgeranylation; Neutrophil degranulation; MET receptor recycling" "4" "1" "0.953" "0.885" "0.908" "0.967" "1.000" "1.031" "0.815" "0.943" "0.567" "215.8" "205.6" "191.1" "196.1" "208.6" "215.9" "222.6" "175.9" "203.5" "122.3" "" "" "" "" "" "" "" "" "" "" "129.2" "106.8" "105.8" "92.0" "96.7" "110.5" "103.5" "79.0" "110.4" "122.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2297110738803864325" "False" "High" "IsMasterProtein" "P30044" "Peroxiredoxin-5, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX5 PE=1 SV=4" "0.000" "False" "27.508" "36" "6" "32" "6" "214" "22.1" "8.70" "73.26" "6" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf08534" "25824" "ENSG00000126432" "PRDX5" "A6NC19; A6NG06; B7ZLJ4; B7ZVW3; hsa:25824; P30044; Q14CK0; Q6IAF2; Q9UBU5; Q9UJU4; Q9UKX4" "Selenium micronutrient network" "" "1" "0" "1.001" "0.977" "1.035" "0.980" "1.005" "1.083" "1.084" "1.041" "0.572" "1405.9" "1407.9" "1373.1" "1454.5" "1377.7" "1412.8" "1522.0" "1523.4" "1463.4" "804.2" "" "" "" "" "" "" "" "" "" "" "841.4" "731.6" "760.4" "682.8" "638.6" "723.3" "707.7" "683.9" "794.0" "804.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "513185524036398277" "False" "High" "IsMasterProtein" "Q9NUQ3" "Gamma-taxilin OS=Homo sapiens OX=9606 GN=TXLNG PE=1 SV=2" "0.000" "False" "27.466" "17" "8" "11" "8" "528" "60.5" "7.52" "29.75" "8" "cell cycle OR cell proliferation;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf09728" "55787" "ENSG00000086712" "TXLNG" "hsa:55787; Q2KQ75; Q5JNZ7; Q9NUQ3; Q9P0X1" "" "" "0" "0" "1.075" "1.059" "1.051" "1.231" "1.032" "1.093" "0.935" "1.137" "1.299" "366.3" "393.9" "388.1" "384.9" "450.9" "378.0" "400.6" "342.7" "416.4" "475.9" "" "" "" "" "" "" "" "" "" "" "219.2" "204.7" "214.9" "180.7" "209.0" "193.5" "186.3" "153.8" "225.9" "475.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6174842833444890787" "False" "High" "IsMasterProtein" "Q99613" "Eukaryotic translation initiation factor 3 subunit C OS=Homo sapiens OX=9606 GN=EIF3C PE=1 SV=1" "0.000" "False" "27.448" "10" "7" "11" "7" "913" "105.3" "5.68" "24.98" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf01399, Pf05470" "8663" "ENSG00000184110" "EIF3C" "A8K7Z0; B2RXG3; B4E1D5; H3BRV0; hsa:8663; O00215; Q99613; Q9BW98" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "1.358" "1.010" "0.906" "1.515" "1.048" "1.178" "0.605" "0.885" "2.377" "85.1" "115.6" "86.0" "77.1" "128.9" "89.2" "100.2" "51.5" "75.3" "202.3" "" "" "" "" "" "" "" "" "" "" "50.9" "60.1" "47.6" "36.2" "59.8" "45.6" "46.6" "23.1" "40.9" "202.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6639457363078970209" "False" "High" "IsMasterProtein" "P35659" "Protein DEK OS=Homo sapiens OX=9606 GN=DEK PE=1 SV=1" "0.000" "False" "27.390" "25" "9" "14" "9" "375" "42.6" "8.56" "33.50" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf08766" "7913" "ENSG00000124795" "DEK" "B2R6K6; B4DN37; hsa:7913; P35659; Q5TGV4; Q5TGV5" "IL-18 signaling pathway; 10q11.21q11.23 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; Transcriptional regulation of granulopoiesis; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors" "5" "0" "0.971" "1.001" "0.969" "1.145" "1.059" "0.894" "0.881" "1.109" "1.955" "526.1" "510.7" "526.8" "509.7" "602.1" "557.0" "470.4" "463.4" "583.2" "1028.3" "" "" "" "" "" "" "" "" "" "" "314.8" "265.4" "291.8" "239.3" "279.1" "285.1" "218.7" "208.1" "316.4" "1028.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6086246065885053041" "False" "High" "IsMasterProtein" "Cont_P02533" "Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4" "0.000" "True" "27.350" "23" "10" "19" "5" "472" "51.5" "5.16" "37.82" "10" "cell organization and biogenesis;other biological processes" "plasma membrane;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00038" "3861" "ENSG00000186847" "KRT14" "hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4" "Corticotropin-releasing hormone signaling pathway" "Formation of the cornified envelope; Type I hemidesmosome assembly" "4" "1" "0.627" "2.401" "0.734" "0.683" "0.743" "0.622" "0.853" "0.923" "1.590" "266.8" "167.4" "640.5" "195.8" "182.3" "198.3" "165.9" "227.5" "246.3" "424.2" "" "" "" "" "" "" "" "" "" "" "159.7" "87.0" "354.7" "91.9" "84.5" "101.5" "77.1" "102.2" "133.6" "424.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3278234146555232268" "False" "High" "IsMasterProtein" "Q96BK5" "PIN2/TERF1-interacting telomerase inhibitor 1 OS=Homo sapiens OX=9606 GN=PINX1 PE=1 SV=2" "0.000" "False" "27.293" "20" "5" "5" "5" "328" "37.0" "9.60" "19.64" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01585" "54984" "ENSG00000254093; ENSG00000284764" "PINX1" "B2R9B1; hsa:54984; Q548A5; Q6QWG9; Q7Z7J8; Q96BK5; Q96QD7; Q9HBU7; Q9NWW2" "" "" "0" "0" "0.956" "0.935" "0.903" "1.013" "0.941" "0.870" "1.043" "0.904" "0.596" "210.1" "200.8" "196.4" "189.8" "212.8" "197.7" "182.8" "219.2" "190.0" "125.2" "" "" "" "" "" "" "" "" "" "" "125.7" "104.3" "108.8" "89.1" "98.6" "101.2" "85.0" "98.4" "103.1" "125.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1723896581553543701" "False" "High" "IsMasterProtein" "Q07666" "KH domain-containing, RNA-binding, signal transduction-associated protein 1 OS=Homo sapiens OX=9606 GN=KHDRBS1 PE=1 SV=1" "0.000" "False" "27.290" "14" "6" "11" "6" "443" "48.2" "8.66" "29.63" "6" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf16274, Pf16568" "10657" "ENSG00000121774" "KHDRBS1" "D3DPP3; hsa:10657; Q07666; Q6PJX7; Q8NB97; Q99760" "Leptin signaling pathway; Primary ovarian insufficiency" "PTK6 Regulates Proteins Involved in RNA Processing" "3" "0" "0.917" "0.949" "0.882" "1.063" "1.037" "1.094" "0.869" "1.067" "1.258" "527.6" "483.8" "500.5" "465.3" "560.7" "547.3" "577.4" "458.6" "563.2" "663.9" "" "" "" "" "" "" "" "" "" "" "315.7" "251.4" "277.1" "218.4" "259.9" "280.2" "268.5" "205.9" "305.5" "663.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1607467674154274672" "False" "High" "IsMasterProtein" "Q8N4Q1" "Mitochondrial intermembrane space import and assembly protein 40 OS=Homo sapiens OX=9606 GN=CHCHD4 PE=1 SV=1" "0.000" "False" "27.183" "37" "5" "10" "5" "142" "16.0" "4.31" "29.37" "5" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "mitochondrion" "other molecular function" "Pf06747" "131474" "ENSG00000163528" "CHCHD4" "A8K3Z9; hsa:131474; Q8N4Q1; Q96AI2; Q96MY6" "" "Mitochondrial protein import" "1" "0" "1.001" "0.978" "1.051" "1.088" "1.075" "1.100" "1.215" "1.025" "0.501" "323.2" "323.5" "316.2" "339.7" "351.7" "347.4" "355.4" "392.6" "331.4" "161.9" "" "" "" "" "" "" "" "" "" "" "193.4" "168.1" "175.1" "159.5" "163.0" "177.9" "165.3" "176.3" "179.8" "161.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "193290723324093172" "False" "High" "IsMasterProtein" "P33316" "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=DUT PE=1 SV=4" "0.000" "False" "27.101" "22" "5" "40" "5" "252" "26.5" "9.36" "99.97" "5" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "mitochondrion;nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf00692" "1854" "ENSG00000128951" "DUT" "A8K650; B4DPR5; hsa:1854; O14785; P33316; Q16708; Q16860; Q6FHN1; Q6NSA3; Q96Q81" "Pyrimidine metabolism" "" "1" "0" "1.021" "1.025" "1.124" "1.073" "1.043" "1.073" "1.111" "1.040" "0.938" "2479.9" "2530.8" "2540.9" "2788.3" "2660.0" "2585.3" "2660.0" "2754.1" "2578.9" "2327.2" "" "" "" "" "" "" "" "" "" "" "1484.1" "1315.2" "1407.1" "1309.1" "1233.0" "1323.5" "1236.9" "1236.4" "1399.1" "2327.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5207555211981118816" "False" "High" "IsMasterProtein" "Q08J23" "RNA cytosine C(5)-methyltransferase NSUN2 OS=Homo sapiens OX=9606 GN=NSUN2 PE=1 SV=2" "0.000" "False" "26.922" "11" "6" "8" "6" "767" "86.4" "6.77" "16.78" "6" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01189" "54888" "ENSG00000037474" "NSUN2" "A8K529; B2RNR4; B3KP09; B4DQW2; G3V1R4; hsa:54888; Q08J23; Q9BVN4; Q9H858; Q9NXD9" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.120" "1.589" "1.047" "1.224" "1.220" "1.117" "0.358" "1.240" "8.379" "69.3" "77.6" "110.1" "72.6" "84.8" "84.5" "77.4" "24.8" "85.9" "580.5" "" "" "" "" "" "" "" "" "" "" "41.5" "40.3" "61.0" "34.1" "39.3" "43.3" "36.0" "11.1" "46.6" "580.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4879961638611313513" "False" "High" "IsMasterProtein" "Q12765" "Secernin-1 OS=Homo sapiens OX=9606 GN=SCRN1 PE=1 SV=2" "0.000" "False" "26.835" "18" "6" "11" "6" "414" "46.4" "4.75" "32.00" "6" "protein metabolism;transport;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf03577" "9805" "ENSG00000136193" "SCRN1" "A8K0E9; B4DHM0; B4DIP5; C9JPG0; hsa:9805; Q12765; Q25QX7; Q8IWD1" "" "" "0" "0" "1.221" "1.198" "1.171" "1.234" "1.152" "1.182" "0.891" "1.182" "2.982" "308.8" "377.1" "369.9" "361.7" "381.0" "355.9" "365.1" "275.1" "365.0" "921.0" "" "" "" "" "" "" "" "" "" "" "184.8" "196.0" "204.9" "169.8" "176.6" "182.2" "169.7" "123.5" "198.0" "921.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2851468461982241185" "False" "High" "IsMasterProtein" "P30626" "Sorcin OS=Homo sapiens OX=9606 GN=SRI PE=1 SV=1" "0.000" "False" "26.834" "36" "7" "20" "7" "198" "21.7" "5.59" "51.58" "7" "transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13499, Pf13833" "6717" "ENSG00000075142" "SRI" "A8MTH6; B4DKK2; D6W5Q0; hsa:6717; P30626" "" "Stimuli-sensing channels; Ion homeostasis; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels; Sodium/Calcium exchangers" "5" "0" "1.076" "1.070" "1.073" "1.140" "1.053" "1.105" "1.030" "1.009" "0.902" "1117.1" "1202.3" "1195.6" "1199.1" "1273.5" "1176.1" "1234.7" "1150.6" "1127.7" "1007.2" "" "" "" "" "" "" "" "" "" "" "668.5" "624.8" "662.1" "562.9" "590.3" "602.1" "574.1" "516.6" "611.8" "1007.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1669697587989024487" "False" "High" "IsMasterProtein" "Q96FW1" "Ubiquitin thioesterase OTUB1 OS=Homo sapiens OX=9606 GN=OTUB1 PE=1 SV=2" "0.000" "False" "26.827" "25" "6" "17" "6" "271" "31.3" "4.94" "49.76" "6" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf10275" "55611" "ENSG00000167770" "OTUB1" "hsa:55611; Q32Q78; Q96FW1; Q96II3; Q9NXQ4; Q9P0B8" "" "Ub-specific processing proteases; Ovarian tumor domain proteases" "2" "0" "0.931" "0.970" "0.883" "0.991" "1.052" "0.889" "0.939" "0.997" "1.271" "1003.7" "934.0" "973.6" "886.0" "994.3" "1055.5" "891.8" "942.0" "1000.8" "1275.7" "" "" "" "" "" "" "" "" "" "" "600.6" "485.4" "539.2" "416.0" "460.9" "540.3" "414.7" "422.9" "543.0" "1275.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1583280322088088435" "False" "High" "IsMasterProtein" "Q9NPF4" "tRNA N6-adenosine threonylcarbamoyltransferase OS=Homo sapiens OX=9606 GN=OSGEP PE=1 SV=1" "0.000" "False" "26.811" "28" "7" "11" "7" "335" "36.4" "6.35" "24.06" "7" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00814" "55644" "ENSG00000092094; ENSG00000291794" "OSGEP" "hsa:55644; Q6IAC3; Q9NPF4" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.960" "0.883" "1.097" "1.047" "0.986" "1.008" "0.997" "0.984" "0.573" "609.5" "584.9" "538.0" "668.4" "638.0" "600.9" "614.1" "607.7" "599.8" "349.1" "" "" "" "" "" "" "" "" "" "" "364.7" "303.9" "297.9" "313.8" "295.7" "307.6" "285.5" "272.8" "325.4" "349.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7680692845404357414" "False" "High" "IsMasterProtein" "P30085" "UMP-CMP kinase OS=Homo sapiens OX=9606 GN=CMPK1 PE=1 SV=3" "0.000" "False" "26.809" "28" "5" "13" "5" "196" "22.2" "5.57" "28.83" "5" "other metabolic processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00406" "51727" "ENSG00000162368" "CMPK1" "B2R6S5; B4DPU7; E9PGI8; hsa:51727; P30085; Q53GB7; Q5SVZ0; Q96C07; Q9UBQ8; Q9UIA2" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "1.109" "1.097" "1.230" "1.245" "1.253" "1.297" "1.175" "1.320" "1.375" "401.3" "445.1" "440.0" "493.7" "499.7" "502.6" "520.6" "471.5" "529.6" "551.9" "" "" "" "" "" "" "" "" "" "" "240.1" "231.3" "243.7" "231.8" "231.6" "257.3" "242.1" "211.7" "287.3" "551.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9119671646432562357" "False" "High" "IsMasterProtein" "P13929" "Beta-enolase OS=Homo sapiens OX=9606 GN=ENO3 PE=1 SV=5" "0.000" "False" "26.796" "15" "5" "17" "1" "434" "47.0" "7.71" "58.51" "5" "other metabolic processes" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf00113, Pf03952" "2027" "ENSG00000108515" "ENO3" "B4DUI6; B4DUM6; D3DTL2; E7ENK8; hsa:2027; P13929; Q96AE2" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2550625188107110862" "False" "High" "IsMasterProtein" "P14550" "Aldo-keto reductase family 1 member A1 OS=Homo sapiens OX=9606 GN=AKR1A1 PE=1 SV=3" "0.000" "False" "26.790" "21" "8" "20" "8" "325" "36.6" "6.79" "50.28" "8" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00248" "10327" "ENSG00000117448" "AKR1A1" "A8KAL8; D3DQ04; hsa:10327; P14550; Q6IAZ4" "Benzo(a)pyrene metabolism; Metapathway biotransformation Phase I and II" "Glutathione conjugation; Formation of xylulose-5-phosphate" "4" "0" "1.016" "1.027" "1.124" "1.024" "1.148" "0.977" "0.962" "1.051" "1.654" "567.4" "576.4" "582.8" "637.5" "581.1" "651.4" "554.6" "545.8" "596.2" "938.1" "" "" "" "" "" "" "" "" "" "" "339.5" "299.5" "322.8" "299.3" "269.3" "333.5" "257.9" "245.0" "323.4" "938.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6115802108714275107" "False" "High" "IsMasterProtein" "P78330" "Phosphoserine phosphatase OS=Homo sapiens OX=9606 GN=PSPH PE=1 SV=2" "0.000" "False" "26.759" "29" "6" "17" "6" "225" "25.0" "5.69" "45.62" "6" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00702" "5723" "ENSG00000146733" "PSPH" "B2RCR5; hsa:5723; P78330; Q7Z3S5" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "Serine biosynthesis" "6" "0" "1.098" "1.011" "1.111" "1.102" "1.013" "1.074" "1.013" "1.033" "0.768" "952.5" "1045.9" "963.0" "1058.5" "1049.2" "964.5" "1023.3" "965.4" "984.3" "731.8" "" "" "" "" "" "" "" "" "" "" "570.0" "543.5" "533.3" "496.9" "486.3" "493.7" "475.8" "433.4" "534.0" "731.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-573717286669998035" "False" "High" "IsMasterProtein" "Q9BY43" "Charged multivesicular body protein 4a OS=Homo sapiens OX=9606 GN=CHMP4A PE=1 SV=3" "0.000" "False" "26.749" "28" "7" "12" "7" "222" "25.1" "4.70" "35.80" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "29082" "ENSG00000254505; ENSG00000285302" "CHMP4A" "hsa:29082; Q14D22; Q32Q79; Q86SZ8; Q96QJ9; Q9BY43; Q9P026" "" "HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "9" "0" "0.970" "0.945" "1.001" "1.104" "1.039" "1.187" "1.161" "1.053" "0.505" "1245.3" "1208.3" "1176.3" "1246.2" "1375.4" "1294.4" "1477.8" "1446.0" "1311.0" "629.1" "" "" "" "" "" "" "" "" "" "" "745.2" "627.9" "651.4" "585.0" "637.5" "662.6" "687.2" "649.2" "711.3" "629.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9204758010535676815" "False" "High" "IsMasterProtein" "Q641Q2" "WASH complex subunit 2A OS=Homo sapiens OX=9606 GN=WASHC2A PE=1 SV=3" "0.000" "False" "26.698" "8" "8" "10" "8" "1341" "147.1" "4.81" "23.62" "8" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15255" "387680" "ENSG00000099290" "WASHC2A" "A2A3S2; A2A3U6; hsa:387680; Q5SNT6; Q641Q2; Q6DHY0" "" "" "0" "0" "1.128" "1.059" "1.125" "1.122" "0.939" "1.297" "1.179" "0.997" "0.962" "143.7" "162.2" "152.2" "161.7" "161.3" "134.9" "186.4" "169.5" "143.4" "138.2" "" "" "" "" "" "" "" "" "" "" "86.0" "84.3" "84.3" "75.9" "74.8" "69.1" "86.7" "76.1" "77.8" "138.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5208996323542288612" "False" "High" "IsMasterProtein" "Q8N5P1" "Zinc finger CCCH domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZC3H8 PE=1 SV=2" "0.000" "False" "26.694" "30" "7" "8" "7" "291" "33.6" "8.28" "23.34" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608, Pf18345" "84524" "ENSG00000144161" "ZC3H8" "hsa:84524; Q8N5P1; Q9BZ75" "2q13 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.033" "0.985" "1.000" "1.016" "1.085" "1.052" "1.103" "1.048" "0.719" "443.9" "458.8" "437.5" "444.0" "451.2" "481.8" "467.1" "489.5" "465.3" "319.1" "" "" "" "" "" "" "" "" "" "" "265.7" "238.4" "242.3" "208.5" "209.1" "246.7" "217.2" "219.8" "252.5" "319.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9037349892504840241" "False" "High" "IsMasterProtein" "O00764" "Pyridoxal kinase OS=Homo sapiens OX=9606 GN=PDXK PE=1 SV=1" "0.000" "False" "26.680" "19" "7" "16" "7" "312" "35.1" "6.13" "49.22" "7" "other metabolic processes" "non-structural extracellular;nucleus;other cell component" "kinase activity;other molecular function" "Pf08543" "8566" "ENSG00000160209" "PDXK" "O00764; Q7Z2Y0; Q9BS02" "" "Neutrophil degranulation; Vitamin B6 activation to pyridoxal phosphate" "2" "0" "0.942" "0.954" "1.087" "1.064" "1.023" "1.210" "1.084" "1.099" "1.001" "716.0" "674.4" "682.8" "778.7" "761.7" "732.7" "866.4" "776.5" "786.6" "716.8" "" "" "" "" "" "" "" "" "" "" "428.5" "350.5" "378.1" "365.6" "353.1" "375.1" "402.9" "348.6" "426.8" "716.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4690988044632206279" "False" "High" "IsMasterProtein" "Q16719" "Kynureninase OS=Homo sapiens OX=9606 GN=KYNU PE=1 SV=1" "0.000" "False" "26.669" "18" "7" "17" "7" "465" "52.3" "7.03" "38.49" "7" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00266" "8942" "ENSG00000115919" "KYNU" "B2RCZ5; D3DP79; hsa:8942; Q16719; Q6I9T2; Q9BVW3" "Selenium micronutrient network; NAD biosynthesis II (from tryptophan); Tryptophan metabolism" "Tryptophan catabolism" "4" "0" "1.053" "1.053" "0.993" "0.954" "0.982" "0.921" "1.032" "0.929" "0.632" "723.3" "761.7" "761.6" "718.5" "689.8" "710.4" "666.4" "746.7" "672.3" "457.4" "" "" "" "" "" "" "" "" "" "" "432.8" "395.8" "421.7" "337.3" "319.7" "363.7" "309.8" "335.2" "364.7" "457.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5049018417817342026" "False" "High" "IsMasterProtein" "P09497" "Clathrin light chain B OS=Homo sapiens OX=9606 GN=CLTB PE=1 SV=1" "0.000" "False" "26.559" "27" "8" "15" "8" "229" "25.2" "4.64" "40.55" "8" "transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01086" "1212" "ENSG00000175416" "CLTB" "hsa:1212; P09497; Q53Y37; Q6FHW1" "Ebola virus infection in host; Fragile X syndrome; 5q35 copy number variation" "Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Formation of annular gap junctions" "11" "0" "1.009" "1.008" "0.966" "1.098" "1.035" "1.060" "1.130" "0.969" "0.497" "947.4" "955.7" "954.9" "915.5" "1040.6" "980.3" "1004.6" "1070.4" "917.8" "471.0" "" "" "" "" "" "" "" "" "" "" "567.0" "496.7" "528.8" "429.8" "482.3" "501.9" "467.1" "480.5" "498.0" "471.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4801012359298608333" "False" "High" "IsMasterProtein" "Q6L8Q7" "2',5'-phosphodiesterase 12 OS=Homo sapiens OX=9606 GN=PDE12 PE=1 SV=2" "0.000" "False" "26.523" "12" "8" "15" "8" "609" "67.3" "6.57" "33.91" "8" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf03372, Pf21171" "201626" "ENSG00000174840" "PDE12" "B4DTU8; hsa:201626; Q6L8Q7; Q8IYU3; Q8NDU2; Q8TE78" "Phosphodiesterases in neuronal function" "OAS antiviral response" "2" "0" "0.951" "0.946" "0.916" "0.955" "1.033" "0.950" "0.970" "0.918" "1.118" "578.3" "549.7" "546.9" "529.5" "552.5" "597.3" "549.4" "560.9" "531.0" "646.5" "" "" "" "" "" "" "" "" "" "" "346.1" "285.7" "302.9" "248.6" "256.1" "305.8" "255.5" "251.8" "288.1" "646.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174373993236338878" "False" "High" "IsMasterProtein" "Q15233" "Non-POU domain-containing octamer-binding protein OS=Homo sapiens OX=9606 GN=NONO PE=1 SV=4" "0.000" "False" "26.466" "18" "9" "23" "7" "471" "54.2" "8.95" "42.71" "9" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08075" "4841" "ENSG00000147140" "NONO" "B7Z4C2; D3DVV4; F5GYZ3; hsa:4841; O00201; P30807; Q12786; Q15233; Q9BQC5" "mRNA processing" "" "1" "1" "0.986" "1.104" "1.026" "1.052" "1.026" "1.011" "0.407" "1.065" "7.042" "615.0" "606.3" "678.7" "630.7" "647.0" "631.3" "621.6" "250.4" "654.8" "4330.8" "" "" "" "" "" "" "" "" "" "" "368.0" "315.1" "375.8" "296.1" "299.9" "323.2" "289.0" "112.4" "355.3" "4330.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5912307548831863099" "False" "High" "IsMasterProtein" "P25398" "Small ribosomal subunit protein eS12 OS=Homo sapiens OX=9606 GN=RPS12 PE=1 SV=3" "0.000" "False" "26.462" "46" "5" "14" "5" "132" "14.5" "7.21" "44.67" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6206" "ENSG00000112306" "RPS12" "hsa:6206; P25398; Q76M58" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.080" "1.169" "1.175" "1.130" "1.111" "1.128" "1.192" "1.223" "0.578" "505.9" "546.3" "591.3" "594.6" "571.7" "562.0" "570.8" "603.0" "618.8" "292.2" "" "" "" "" "" "" "" "" "" "" "302.8" "283.9" "327.5" "279.2" "265.0" "287.7" "265.4" "270.7" "335.7" "292.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3546401136209877532" "False" "High" "IsMasterProtein" "O75821" "Eukaryotic translation initiation factor 3 subunit G OS=Homo sapiens OX=9606 GN=EIF3G PE=1 SV=2" "0.000" "False" "26.455" "17" "5" "7" "5" "320" "35.6" "6.13" "25.80" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00076, Pf12353" "8666" "ENSG00000130811" "EIF3G" "hsa:8666; O14801; O75821; Q969U5" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "1.030" "1.182" "1.110" "1.057" "1.044" "1.044" "0.973" "1.131" "1.946" "585.1" "602.8" "691.5" "649.7" "618.2" "610.9" "610.5" "569.5" "661.4" "1138.4" "" "" "" "" "" "" "" "" "" "" "350.1" "313.3" "382.9" "305.0" "286.6" "312.7" "283.9" "255.7" "358.8" "1138.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2236542177406705002" "False" "High" "IsMasterProtein" "P52597" "Heterogeneous nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=HNRNPF PE=1 SV=3" "0.000" "False" "26.432" "28" "8" "17" "6" "415" "45.6" "5.58" "35.24" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08080" "3185" "ENSG00000169813" "HNRNPF" "B3KM84; hsa:3185; P52597; Q5T0N2; Q96AU2" "MECP2 and associated Rett syndrome" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "5" "0" "1.007" "1.092" "1.069" "1.106" "1.062" "0.960" "0.694" "1.043" "3.905" "186.2" "187.6" "203.4" "199.0" "205.9" "197.7" "178.7" "129.2" "194.3" "727.2" "" "" "" "" "" "" "" "" "" "" "111.4" "97.5" "112.6" "93.4" "95.5" "101.2" "83.1" "58.0" "105.4" "727.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6072091565905259276" "False" "High" "IsMasterProtein" "P42574" "Caspase-3 OS=Homo sapiens OX=9606 GN=CASP3 PE=1 SV=2" "0.000" "False" "26.425" "18" "4" "19" "4" "277" "31.6" "6.54" "49.16" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00656" "836" "ENSG00000164305" "CASP3" "A8K5M2; D3DP53; hsa:836; P42574; Q96AN1; Q96KP2" "miRNA regulation of DNA damage response; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft rejection; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Copper homeostasis; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; ERK pathway in Huntington's disease; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Prion disease pathway; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; MTHFR deficiency; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; Complement system in neuronal development and plasticity; Orexin receptor pathway; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Urotensin-II-mediated signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; IL-26 signaling pathways; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response" "Caspase-mediated cleavage of cytoskeletal proteins; Degradation of the extracellular matrix; Other interleukin signaling; Apoptosis induced DNA fragmentation; Signaling by Hippo; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Caspase activation via Dependence Receptors in the absence of ligand; Pyroptosis; NADE modulates death signalling; Apoptotic cleavage of cell adhesion proteins; Stimulation of the cell death response by PAK-2p34" "60" "0" "1.037" "0.975" "1.166" "1.064" "1.076" "1.063" "1.055" "1.043" "0.568" "841.0" "871.9" "819.8" "980.7" "895.2" "905.1" "894.3" "887.2" "877.4" "477.3" "" "" "" "" "" "" "" "" "" "" "503.3" "453.1" "454.0" "460.4" "414.9" "463.4" "415.8" "398.3" "476.0" "477.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6634363274650926044" "False" "High" "IsMasterProtein" "Q14839" "Chromodomain-helicase-DNA-binding protein 4 OS=Homo sapiens OX=9606 GN=CHD4 PE=1 SV=2" "0.000" "False" "26.381" "6" "8" "8" "8" "1912" "217.9" "5.86" "18.77" "8" "cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf00628, Pf06461, Pf06465, Pf08073, Pf08074" "1108" "ENSG00000111642" "CHD4" "Q14839; Q8IXZ5" "Rett syndrome; Effect of progerin on genes involved in progeria" "RNA Polymerase I Transcription Initiation; Potential therapeutics for SARS; HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; Regulation of TP53 Activity through Acetylation; NGF-stimulated transcription" "9" "0" "0.974" "1.000" "1.127" "0.980" "1.357" "1.106" "0.511" "1.215" "7.091" "55.7" "54.3" "55.7" "62.8" "54.6" "75.6" "61.6" "28.5" "67.7" "395.0" "" "" "" "" "" "" "" "" "" "" "33.3" "28.2" "30.8" "29.5" "25.3" "38.7" "28.6" "12.8" "36.7" "395.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7294352330531963904" "False" "High" "IsMasterProtein" "Q99439" "Calponin-2 OS=Homo sapiens OX=9606 GN=CNN2 PE=1 SV=4" "0.000" "False" "26.361" "22" "6" "9" "6" "309" "33.7" "7.33" "26.47" "6" "cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00402" "1265" "ENSG00000064666" "CNN2" "A5D8U8; A6NFI4; D6W5X9; hsa:1265; Q92578; Q99439" "Myometrial relaxation and contraction pathways; Burn wound healing" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "4" "0" "1.277" "1.295" "1.123" "1.190" "1.121" "1.108" "0.951" "1.319" "4.027" "333.4" "425.7" "431.6" "374.2" "396.7" "373.6" "369.3" "317.1" "439.8" "1342.6" "" "" "" "" "" "" "" "" "" "" "199.5" "221.2" "239.0" "175.7" "183.9" "191.2" "171.7" "142.4" "238.6" "1342.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "175169128914004892" "False" "High" "IsMasterProtein" "Q30154" "HLA class II histocompatibility antigen, DR beta 5 chain OS=Homo sapiens OX=9606 GN=HLA-DRB5 PE=1 SV=1" "0.000" "False" "26.211" "24" "6" "11" "4" "266" "30.0" "6.93" "38.46" "6" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00969, Pf07654" "3127" "ENSG00000198502" "HLA-DRB5" "B2RBV6; C7C4X3; hsa:3127; O00157; O00283; O46700; Q29703; Q29787; Q29788; Q30126; Q30150; Q30154; Q30199; Q6SJR2; Q7M2H9; Q8HWS7; Q8WLR5; Q9MY54; Q9XRX6" "Allograft rejection; Ebola virus infection in host; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway" "Interferon gamma signaling; Downstream TCR signaling; MHC class II antigen presentation; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling" "11" "0" "0.988" "1.033" "0.954" "1.093" "0.998" "1.013" "0.964" "1.160" "1.118" "403.3" "398.5" "416.6" "384.6" "440.7" "402.7" "408.6" "388.8" "467.7" "451.0" "" "" "" "" "" "" "" "" "" "" "241.4" "207.1" "230.7" "180.6" "204.3" "206.1" "190.0" "174.5" "253.8" "451.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7644336301377244123" "False" "High" "IsMasterProtein" "Q8IZ83" "Aldehyde dehydrogenase family 16 member A1 OS=Homo sapiens OX=9606 GN=ALDH16A1 PE=1 SV=2" "0.000" "False" "26.137" "8" "6" "8" "6" "802" "85.1" "6.79" "22.25" "6" "" "" "other molecular function" "Pf00171" "126133" "ENSG00000161618" "ALDH16A1" "B4DLQ1; C9JBH6; hsa:126133; Q86YF0; Q8IYL4; Q8IZ83; Q8TEI8" "" "" "0" "0" "1.111" "0.959" "1.091" "1.154" "1.151" "1.096" "1.165" "1.121" "0.699" "204.9" "227.7" "196.4" "223.5" "236.4" "235.7" "224.5" "238.6" "229.6" "143.2" "" "" "" "" "" "" "" "" "" "" "122.6" "118.3" "108.8" "104.9" "109.6" "120.7" "104.4" "107.1" "124.6" "143.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2238479499176412626" "False" "High" "IsMasterProtein" "O60828" "Polyglutamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PQBP1 PE=1 SV=1" "0.000" "False" "26.105" "28" "6" "11" "6" "265" "30.5" "6.33" "30.18" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "10084" "ENSG00000102103; ENSG00000292208" "PQBP1" "C9JQA1; hsa:10084; O60828; Q4VY25; Q4VY26; Q4VY27; Q4VY29; Q4VY30; Q4VY34; Q4VY35; Q4VY36; Q4VY37; Q4VY38; Q9GZP2; Q9GZU4; Q9GZZ4" "" "mRNA Splicing - Major Pathway" "1" "0" "1.147" "1.093" "1.040" "1.021" "0.974" "0.989" "0.976" "0.895" "0.610" "670.6" "769.0" "733.0" "697.5" "684.9" "653.1" "663.1" "654.4" "600.4" "408.7" "" "" "" "" "" "" "" "" "" "" "401.3" "399.6" "405.9" "327.4" "317.5" "334.4" "308.3" "293.8" "325.7" "408.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7105726009165371323" "False" "High" "IsMasterProtein" "P13995" "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD2 PE=1 SV=2" "0.000" "False" "26.092" "19" "7" "17" "7" "350" "37.9" "8.73" "43.68" "7" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00763, Pf02882" "10797" "ENSG00000065911" "MTHFD2" "hsa:10797; P13995; Q53G90; Q53GV5; Q53S36; Q7Z650" "Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways" "Metabolism of folate and pterines" "4" "0" "0.991" "1.016" "1.080" "1.133" "0.973" "1.099" "1.121" "1.029" "0.942" "674.6" "668.5" "685.4" "728.3" "764.5" "656.2" "741.6" "756.4" "694.0" "635.6" "" "" "" "" "" "" "" "" "" "" "403.7" "347.4" "379.6" "341.9" "354.3" "335.9" "344.8" "339.6" "376.5" "635.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3464884523288308990" "False" "High" "IsMasterProtein" "Q12972" "Nuclear inhibitor of protein phosphatase 1 OS=Homo sapiens OX=9606 GN=PPP1R8 PE=1 SV=2" "0.000" "False" "26.013" "18" "5" "6" "5" "351" "38.5" "7.37" "20.11" "5" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00498" "5511" "ENSG00000117751" "PPP1R8" "hsa:5511; Q12972; Q5TEJ2; Q5TEJ4; Q5TIF2; Q6PKF6; Q9UBH1; Q9UBZ0" "" "mRNA Splicing - Major Pathway" "1" "0" "1.012" "1.117" "1.086" "1.044" "1.101" "1.028" "1.177" "0.997" "1.406" "314.1" "317.9" "350.9" "341.2" "328.0" "345.7" "322.8" "369.7" "313.1" "441.6" "" "" "" "" "" "" "" "" "" "" "188.0" "165.2" "194.3" "160.2" "152.0" "177.0" "150.1" "166.0" "169.9" "441.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491921153129945541" "False" "High" "IsMasterProtein" "Q9UHV9" "Prefoldin subunit 2 OS=Homo sapiens OX=9606 GN=PFDN2 PE=1 SV=1" "0.000" "False" "26.004" "34" "5" "15" "5" "154" "16.6" "6.58" "37.03" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01920" "5202" "ENSG00000143256" "PFDN2" "hsa:5202; Q9P0P7; Q9UHV9; Q9UN05" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "1.045" "0.901" "1.377" "1.168" "0.897" "1.331" "1.150" "0.911" "0.738" "884.0" "923.8" "796.0" "1217.2" "1032.9" "792.7" "1176.2" "1016.7" "804.9" "652.8" "" "" "" "" "" "" "" "" "" "" "529.0" "480.1" "440.8" "571.5" "478.7" "405.8" "546.9" "456.4" "436.7" "652.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7512060777885112035" "False" "High" "IsMasterProtein" "P63244" "Small ribosomal subunit protein RACK1 OS=Homo sapiens OX=9606 GN=RACK1 PE=1 SV=3" "0.000" "False" "25.939" "20" "6" "18" "6" "317" "35.1" "7.69" "50.28" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;cytosol;mitochondrion;translational apparatus;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;translation activity;other molecular function" "Pf00400" "10399" "ENSG00000204628" "RACK1" "B3KTJ0; D3DWS0; hsa:10399; P25388; P63244; P99049; Q53HU2; Q5J8M6; Q5VLR4; Q6FH47" "Androgen receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; Measles virus infection; Angiotensin II receptor type 1 pathway; TROP2 regulatory signaling; Interferon type I signaling pathways" "Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-mediated ceramide production" "10" "0" "1.087" "1.014" "1.141" "1.014" "1.163" "1.028" "1.107" "1.156" "1.845" "956.7" "1040.0" "970.3" "1091.9" "969.7" "1112.6" "983.4" "1059.0" "1105.7" "1765.3" "" "" "" "" "" "" "" "" "" "" "572.5" "540.5" "537.3" "512.6" "449.5" "569.6" "457.3" "475.4" "599.9" "1765.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7478524853152137733" "False" "High" "IsMasterProtein" "P43487" "Ran-specific GTPase-activating protein OS=Homo sapiens OX=9606 GN=RANBP1 PE=1 SV=1" "0.000" "False" "25.862" "19" "4" "21" "4" "201" "23.3" "5.29" "69.23" "4" "transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00638" "5902" "ENSG00000099901" "RANBP1" "hsa:5902; P43487; Q53EY3" "22q11.2 copy number variation syndrome" "Rev-mediated nuclear export of HIV RNA" "2" "0" "1.055" "1.084" "0.993" "1.063" "1.065" "1.123" "1.125" "0.974" "0.939" "2975.7" "3139.2" "3225.5" "2953.4" "3164.6" "3170.4" "3342.8" "3347.9" "2899.7" "2793.6" "" "" "" "" "" "" "" "" "" "" "1780.8" "1631.3" "1786.2" "1386.5" "1466.8" "1623.0" "1554.3" "1503.0" "1573.2" "2793.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6780722004559034825" "False" "High" "IsMasterProtein" "P35520" "Cystathionine beta-synthase OS=Homo sapiens OX=9606 GN=CBS PE=1 SV=2" "0.000" "False" "25.847" "15" "9" "15" "9" "551" "60.5" "6.65" "39.06" "9" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00291, Pf00571" "102724560; 875" "ENSG00000160200" "CBS" "B2R993; D3DSK4; hsa:102724560; hsa:875; P35520; Q99425; Q9BWC5" "Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Folate metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Vitamin D receptor pathway; Amino acid metabolism; Methionine metabolism leading to sulfur amino acids and related disorders; Ferroptosis; Ciliary landscape" "Metabolism of ingested SeMet, Sec, MeSec into H2Se; Cysteine formation from homocysteine" "13" "0" "1.100" "0.937" "1.071" "0.912" "1.002" "0.959" "1.037" "0.968" "0.615" "841.4" "925.3" "788.3" "900.9" "767.3" "843.0" "807.0" "872.9" "814.6" "517.4" "" "" "" "" "" "" "" "" "" "" "503.5" "480.8" "436.5" "422.9" "355.7" "431.6" "375.2" "391.9" "441.9" "517.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3113703590403153606" "False" "High" "IsMasterProtein" "Q96EP5" "DAZ-associated protein 1 OS=Homo sapiens OX=9606 GN=DAZAP1 PE=1 SV=1" "0.000" "False" "25.846" "14" "4" "22" "4" "407" "43.4" "8.56" "59.57" "4" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "26528" "ENSG00000071626" "DAZAP1" "hsa:26528; Q96EP5; Q96MJ3; Q9NRR9" "" "" "0" "0" "1.030" "0.967" "1.077" "1.030" "0.893" "1.031" "0.906" "0.962" "0.666" "853.0" "878.5" "824.4" "918.7" "878.6" "761.4" "879.6" "772.5" "820.3" "567.7" "" "" "" "" "" "" "" "" "" "" "510.5" "456.5" "456.5" "431.3" "407.3" "389.8" "409.0" "346.8" "445.0" "567.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1042042739323188079" "False" "High" "IsMasterProtein" "Q9UQ35" "Serine/arginine repetitive matrix protein 2 OS=Homo sapiens OX=9606 GN=SRRM2 PE=1 SV=2" "0.000" "False" "25.841" "3" "7" "8" "7" "2752" "299.4" "12.06" "20.65" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08312" "23524" "ENSG00000167978" "SRRM2" "A6NKB9; D3DU97; hsa:23524; O15038; O94803; Q6NSL3; Q6PIM3; Q6PK40; Q8IW17; Q96GY7; Q9P0G1; Q9UHA8; Q9UQ35; Q9UQ36; Q9UQ37; Q9UQ38; Q9UQ40" "" "mRNA Splicing - Major Pathway" "1" "0" "1.092" "1.121" "1.135" "1.049" "0.998" "1.065" "1.175" "1.132" "1.261" "263.6" "287.8" "295.6" "299.1" "276.6" "263.0" "280.7" "309.7" "298.5" "332.3" "" "" "" "" "" "" "" "" "" "" "157.8" "149.5" "163.7" "140.4" "128.2" "134.6" "130.5" "139.0" "161.9" "332.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1425618486899947959" "False" "High" "IsMasterProtein" "Q7Z4H3" "5'-deoxynucleotidase HDDC2 OS=Homo sapiens OX=9606 GN=HDDC2 PE=1 SV=1" "0.000" "False" "25.793" "27" "5" "9" "5" "204" "23.4" "5.49" "23.48" "5" "" "" "other molecular function" "Pf13023" "51020" "ENSG00000111906" "HDDC2" "hsa:51020; Q5TDQ4; Q6NZ49; Q7Z4H3; Q9BTT2; Q9BV31; Q9Y3D1" "" "" "0" "0" "1.034" "0.937" "0.993" "1.176" "1.084" "1.127" "1.082" "0.994" "0.460" "520.1" "537.5" "487.4" "516.6" "611.7" "563.6" "586.0" "562.9" "516.7" "239.2" "" "" "" "" "" "" "" "" "" "" "311.2" "279.3" "269.9" "242.6" "283.5" "288.5" "272.5" "252.7" "280.3" "239.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6100436114582122401" "False" "High" "IsMasterProtein" "Q93034" "Cullin-5 OS=Homo sapiens OX=9606 GN=CUL5 PE=1 SV=4" "0.000" "False" "25.789" "10" "8" "10" "8" "780" "90.9" "7.94" "26.02" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;signal transduction" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf00888, Pf10557" "8065" "ENSG00000166266" "CUL5" "A8K960; O14766; Q93034; Q9BZC6" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Dual hijack model of Vif in HIV infection; Modulators of TCR signaling and T cell activation; 10q11.21q11.23 copy number variation syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling; Downregulation of ERBB2 signaling; Evasion by RSV of host interferon responses" "10" "0" "1.050" "0.966" "0.989" "1.028" "1.029" "0.967" "1.021" "1.007" "0.646" "403.6" "423.8" "389.9" "399.3" "414.8" "415.3" "390.3" "412.2" "406.5" "260.9" "" "" "" "" "" "" "" "" "" "" "241.5" "220.3" "215.9" "187.5" "192.3" "212.6" "181.5" "185.1" "220.6" "260.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2958719848471143183" "False" "High" "IsMasterProtein" "P54687" "Branched-chain-amino-acid aminotransferase, cytosolic OS=Homo sapiens OX=9606 GN=BCAT1 PE=1 SV=3" "0.000" "False" "25.781" "16" "6" "50" "6" "386" "42.9" "5.30" "117.60" "6" "cell cycle OR cell proliferation;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01063" "586" "ENSG00000060982" "BCAT1" "B3KY27; B7Z2M5; B7Z5L0; F5H5E4; hsa:586; P54687; Q68DQ7; Q96MY9" "Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways" "Branched-chain amino acid catabolism" "4" "0" "0.992" "0.976" "0.922" "0.976" "0.813" "1.087" "0.843" "1.077" "0.561" "3806.2" "3774.8" "3716.2" "3510.7" "3714.5" "3092.5" "4138.0" "3208.3" "4098.9" "2133.7" "" "" "" "" "" "" "" "" "" "" "2277.8" "1961.6" "2057.9" "1648.2" "1721.7" "1583.1" "1924.1" "1440.3" "2223.8" "2133.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7029277553794243506" "False" "High" "IsMasterProtein" "P61244" "Protein max OS=Homo sapiens OX=9606 GN=MAX PE=1 SV=1" "0.000" "False" "25.762" "38" "6" "8" "6" "160" "18.3" "6.30" "25.46" "6" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "4149" "ENSG00000125952" "MAX" "A6NH73; A8K265; A8K4G4; A8K824; hsa:4149; P25912; P52163; P61244; Q14803; Q96CY8" "B cell receptor signaling pathway; Pathways affected in adenoid cystic carcinoma; MAPK signaling pathway; p38 MAPK signaling pathway; Small cell lung cancer; Pleural mesothelioma; 5q35 copy number variation" "Transcriptional Regulation by E2F6; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry" "11" "0" "1.074" "0.994" "0.993" "1.091" "1.074" "1.025" "1.269" "1.089" "0.496" "522.7" "561.4" "519.3" "519.2" "570.1" "561.4" "535.6" "663.3" "569.4" "259.1" "" "" "" "" "" "" "" "" "" "" "312.8" "291.8" "287.6" "243.8" "264.2" "287.4" "249.0" "297.8" "308.9" "259.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2633610480889665575" "False" "High" "IsMasterProtein" "O75608" "Acyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=LYPLA1 PE=1 SV=1" "0.000" "False" "25.758" "17" "4" "32" "4" "230" "24.7" "6.77" "91.42" "4" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02230" "10434" "ENSG00000120992" "LYPLA1" "hsa:10434; O43202; O75608; Q9UQF9" "" "RAS processing; eNOS activation" "2" "0" "1.067" "0.979" "1.075" "1.033" "0.997" "1.022" "1.022" "0.979" "0.649" "1261.7" "1345.8" "1235.2" "1356.8" "1303.3" "1257.5" "1289.1" "1289.3" "1234.6" "818.9" "" "" "" "" "" "" "" "" "" "" "755.1" "699.4" "684.0" "637.0" "604.1" "643.8" "599.4" "578.8" "669.8" "818.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1787588940823929001" "False" "High" "IsMasterProtein" "P61224" "Ras-related protein Rap-1b OS=Homo sapiens OX=9606 GN=RAP1B PE=1 SV=1" "0.000" "False" "25.691" "30" "5" "8" "5" "184" "20.8" "5.78" "23.29" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5908" "ENSG00000127314" "RAP1B" "B2R5Z2; B4DQI8; B4DW74; B4DW94; hsa:5908; P09526; P61224; Q502X3; Q5TZR4; Q6DCA1; Q6LES0" "Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Androgen receptor network in prostate cancer; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Rap1 signalling; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1" "26" "0" "1.051" "0.923" "1.025" "1.118" "0.957" "1.109" "1.053" "1.203" "0.580" "385.9" "405.5" "356.2" "395.6" "431.4" "369.2" "428.1" "406.3" "464.1" "223.7" "" "" "" "" "" "" "" "" "" "" "230.9" "210.7" "197.2" "185.7" "199.9" "189.0" "199.0" "182.4" "251.8" "223.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3877327812570757942" "False" "High" "IsMasterProtein" "P50570" "Dynamin-2 OS=Homo sapiens OX=9606 GN=DNM2 PE=1 SV=2" "0.000" "False" "25.672" "11" "10" "14" "10" "870" "98.0" "7.44" "37.44" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00350, Pf01031, Pf02212" "1785" "ENSG00000079805" "DNM2" "A8K1B6; E7EV30; E9PEQ4; hsa:1785; K7ESI9; P50570; Q5I0Y0; Q7Z5S3; Q9UPH4" "Synaptic vesicle pathway; Fragile X syndrome; Intracellular trafficking proteins involved in CMT neuropathy" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Recycling pathway of L1; NGF-stimulated transcription; Toll Like Receptor 4 (TLR4) Cascade; NOSTRIN mediated eNOS trafficking; Retrograde neurotrophin signalling; Formation of annular gap junctions" "14" "0" "1.029" "1.013" "1.122" "1.158" "1.076" "1.109" "0.839" "0.974" "4.118" "390.5" "401.8" "395.5" "438.2" "452.3" "420.4" "433.0" "327.6" "380.5" "1608.3" "" "" "" "" "" "" "" "" "" "" "233.7" "208.8" "219.0" "205.7" "209.6" "215.2" "201.3" "147.1" "206.5" "1608.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7181464862980127615" "False" "High" "IsMasterProtein" "Q13630" "GDP-L-fucose synthase OS=Homo sapiens OX=9606 GN=GFUS PE=1 SV=1" "0.000" "False" "25.659" "21" "5" "6" "5" "321" "35.9" "6.60" "22.14" "5" "cell adhesion;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01370" "7264" "ENSG00000104522; ENSG00000278243" "GFUS" "B2R8Y7; D3DWK5; hsa:7264; Q13630; Q567Q9; Q9UDG7" "" "GDP-fucose biosynthesis" "1" "0" "1.118" "1.023" "1.066" "1.242" "1.138" "1.061" "1.106" "0.966" "0.698" "199.8" "223.4" "204.5" "213.1" "248.1" "227.3" "211.9" "221.0" "193.0" "139.4" "" "" "" "" "" "" "" "" "" "" "119.6" "116.1" "113.2" "100.0" "115.0" "116.4" "98.5" "99.2" "104.7" "139.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2951553745667677229" "False" "High" "IsMasterProtein" "P31689" "DnaJ homolog subfamily A member 1 OS=Homo sapiens OX=9606 GN=DNAJA1 PE=1 SV=2" "0.000" "False" "25.658" "20" "6" "10" "6" "397" "44.8" "7.08" "29.46" "6" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00226, Pf00684, Pf01556" "3301" "ENSG00000086061" "DNAJA1" "hsa:3301; P31689; Q5T7Q0; Q86TL9" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation; HDAC6 interactions in the central nervous system" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "4" "0" "0.933" "0.958" "0.928" "1.057" "0.948" "1.115" "0.706" "1.163" "4.067" "394.6" "368.1" "378.2" "366.2" "417.2" "373.9" "440.1" "278.6" "458.8" "1604.7" "" "" "" "" "" "" "" "" "" "" "236.1" "191.3" "209.4" "171.9" "193.4" "191.4" "204.6" "125.1" "248.9" "1604.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3557205944014884156" "False" "High" "IsMasterProtein" "P20339" "Ras-related protein Rab-5A OS=Homo sapiens OX=9606 GN=RAB5A PE=1 SV=2" "0.000" "False" "25.535" "26" "5" "14" "2" "215" "23.6" "8.15" "36.92" "5" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5868" "ENSG00000144566" "RAB5A" "B4DJA5; hsa:5868; P20339; Q6FI44" "Amyotrophic lateral sclerosis (ALS); VEGFA-VEGFR2 signaling; Ebola virus infection in host; Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway; 16p11.2 distal deletion syndrome; Vasopressin-regulated water reabsorption" "Synthesis of PIPs at the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; Factors involved in megakaryocyte development and platelet production; Prevention of phagosomal-lysosomal fusion; TBC/RABGAPs" "16" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3739343134974919134" "False" "High" "IsMasterProtein" "Q92804" "TATA-binding protein-associated factor 2N OS=Homo sapiens OX=9606 GN=TAF15 PE=1 SV=1" "0.000" "False" "25.513" "10" "4" "13" "2" "592" "61.8" "8.02" "37.83" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "8148" "ENSG00000270647; ENSG00000276833" "TAF15" "B2R837; hsa:8148; Q86X94; Q92751; Q92804" "17q12 copy number variation syndrome" "Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-116543853618974429" "False" "High" "IsMasterProtein" "P20338" "Ras-related protein Rab-4A OS=Homo sapiens OX=9606 GN=RAB4A PE=1 SV=3" "0.000" "False" "25.508" "20" "4" "12" "1" "218" "24.4" "6.07" "36.03" "4" "transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5867" "ENSG00000168118" "RAB4A" "hsa:5867; P20338; Q5T7P7; Q9BQ44" "VEGFA-VEGFR2 signaling; Insulin signaling; Intracellular trafficking proteins involved in CMT neuropathy; 16p11.2 distal deletion syndrome" "TBC/RABGAPs; RAB geranylgeranylation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Synthesis of PIPs at the plasma membrane; MET receptor recycling" "9" "0" "0.972" "0.924" "0.986" "1.151" "1.034" "1.010" "0.953" "1.118" "0.502" "79.6" "77.4" "73.6" "78.4" "91.5" "82.3" "80.3" "75.8" "89.0" "39.9" "" "" "" "" "" "" "" "" "" "" "47.6" "40.2" "40.7" "36.8" "42.4" "42.1" "37.4" "34.0" "48.3" "39.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5905184492137342602" "False" "High" "IsMasterProtein" "P08559" "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Homo sapiens OX=9606 GN=PDHA1 PE=1 SV=3" "0.000" "False" "25.498" "17" "7" "10" "7" "390" "43.3" "8.06" "26.84" "7" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00676" "5160" "ENSG00000131828" "PDHA1" "A5YVE9; B2R5P7; B7Z3T7; B7Z3X5; hsa:5160; P08559; Q53H41; Q5JPT8; Q9NP12; Q9UBJ8; Q9UBU0; Q9UNG4; Q9UNG5" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Lipid metabolism pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways; TCA cycle in senescence; Neuroinflammation and glutamatergic signaling; Acetylcholine synthesis; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "17" "0" "0.958" "1.016" "1.126" "1.128" "1.053" "1.112" "1.035" "1.045" "1.586" "365.8" "350.5" "371.6" "411.8" "412.6" "385.0" "406.9" "378.7" "382.3" "580.2" "" "" "" "" "" "" "" "" "" "" "218.9" "182.1" "205.8" "193.3" "191.2" "197.1" "189.2" "170.0" "207.4" "580.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6175620915795625691" "False" "High" "IsMasterProtein" "Q13151" "Heterogeneous nuclear ribonucleoprotein A0 OS=Homo sapiens OX=9606 GN=HNRNPA0 PE=1 SV=1" "0.000" "False" "25.492" "19" "5" "40" "4" "305" "30.8" "9.29" "99.65" "5" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "10949" "ENSG00000177733" "HNRNPA0" "hsa:10949; Q13151; Q6IB18" "" "" "0" "0" "0.895" "1.024" "1.020" "1.234" "1.019" "0.726" "0.503" "1.080" "6.712" "96.8" "86.6" "99.1" "98.7" "119.4" "98.6" "70.3" "48.7" "104.6" "649.6" "" "" "" "" "" "" "" "" "" "" "57.9" "45.0" "54.9" "46.3" "55.3" "50.5" "32.7" "21.9" "56.7" "649.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5394846730023349610" "False" "High" "IsMasterProtein" "P55081" "Microfibrillar-associated protein 1 OS=Homo sapiens OX=9606 GN=MFAP1 PE=1 SV=2" "0.000" "False" "25.489" "18" "7" "11" "7" "439" "51.9" "4.98" "29.50" "7" "RNA metabolism OR transcription;other metabolic processes" "extracellular matrix;cytoskeleton;nucleus" "" "Pf06991" "4236" "ENSG00000140259" "MFAP1" "hsa:4236; P55081; Q86TG6" "Canonical and non-canonical Notch signaling; Ciliary landscape" "mRNA Splicing - Major Pathway" "3" "0" "1.011" "1.081" "0.963" "1.091" "1.063" "1.028" "1.067" "0.970" "0.176" "949.3" "959.8" "1026.6" "914.4" "1036.0" "1009.0" "975.8" "1013.0" "921.3" "167.2" "" "" "" "" "" "" "" "" "" "" "568.1" "498.7" "568.5" "429.3" "480.2" "516.6" "453.7" "454.8" "499.8" "167.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-469021931412063719" "False" "High" "IsMasterProtein" "P53618" "Coatomer subunit beta OS=Homo sapiens OX=9606 GN=COPB1 PE=1 SV=3" "0.000" "False" "25.483" "8" "8" "11" "8" "953" "107.1" "6.05" "23.89" "8" "transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01602, Pf07718, Pf14806" "1315" "ENSG00000129083" "COPB1" "D3DQX0; hsa:1315; P53618; Q6GTT7; Q9NTK2; Q9UNW7" "" "Neutrophil degranulation; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "3" "0" "1.129" "0.985" "1.012" "1.584" "1.152" "1.191" "0.859" "1.004" "2.717" "55.2" "62.3" "54.4" "55.9" "87.5" "63.6" "65.8" "47.4" "55.5" "150.1" "" "" "" "" "" "" "" "" "" "" "33.1" "32.4" "30.1" "26.2" "40.5" "32.6" "30.6" "21.3" "30.1" "150.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9217624131527771053" "False" "High" "IsMasterProtein" "O00330" "Pyruvate dehydrogenase protein X component, mitochondrial OS=Homo sapiens OX=9606 GN=PDHX PE=1 SV=3" "0.000" "False" "25.425" "14" "7" "9" "7" "501" "54.1" "8.66" "22.46" "7" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00198, Pf00364, Pf02817" "8050" "ENSG00000110435" "PDHX" "B4DW62; D3DR11; E9PB14; E9PBP7; hsa:8050; O00330; O60221; Q96FV8; Q99783" "Amino acid metabolism" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "5" "0" "1.064" "0.912" "1.046" "1.066" "1.044" "1.131" "1.044" "1.053" "0.652" "552.3" "587.8" "503.9" "577.5" "588.9" "576.6" "624.6" "576.6" "581.5" "360.1" "" "" "" "" "" "" "" "" "" "" "330.5" "305.5" "279.0" "271.1" "273.0" "295.2" "290.4" "258.8" "315.5" "360.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5216339322949848557" "False" "High" "IsMasterProtein" "Q96PZ0" "Pseudouridylate synthase 7 homolog OS=Homo sapiens OX=9606 GN=PUS7 PE=1 SV=2" "0.000" "False" "25.422" "17" "10" "13" "10" "661" "75.0" "6.37" "25.48" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01142" "54517" "ENSG00000091127" "PUS7" "hsa:54517; Q75MG4; Q96PZ0; Q9NX19" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.039" "1.060" "1.040" "1.095" "1.086" "1.006" "0.950" "1.071" "1.056" "613.4" "637.1" "650.5" "638.1" "671.8" "666.0" "617.0" "582.9" "657.1" "647.5" "" "" "" "" "" "" "" "" "" "" "367.1" "331.1" "360.2" "299.6" "311.4" "340.9" "286.9" "261.7" "356.5" "647.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6575553270224251994" "False" "High" "IsMasterProtein" "P55010" "Eukaryotic translation initiation factor 5 OS=Homo sapiens OX=9606 GN=EIF5 PE=1 SV=2" "0.000" "False" "25.415" "14" "7" "15" "7" "431" "49.2" "5.58" "31.94" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01873, Pf02020" "1983" "ENSG00000100664" "EIF5" "hsa:1983; P55010; Q53XB3; Q9H5N2; Q9UG48" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "4" "0" "1.114" "1.116" "1.147" "1.146" "1.060" "1.025" "0.854" "0.984" "2.334" "409.3" "455.9" "456.6" "469.2" "469.1" "433.7" "419.5" "349.4" "402.7" "955.4" "" "" "" "" "" "" "" "" "" "" "244.9" "236.9" "252.8" "220.3" "217.4" "222.0" "195.1" "156.9" "218.5" "955.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8835450799000805125" "False" "High" "IsMasterProtein" "Q8N1F7" "Nuclear pore complex protein Nup93 OS=Homo sapiens OX=9606 GN=NUP93 PE=1 SV=2" "0.000" "False" "25.406" "11" "9" "9" "9" "819" "93.4" "5.72" "22.69" "9" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf04097" "9688" "ENSG00000102900" "NUP93" "B3KPQ8; hsa:9688; Q14705; Q8N1F7" "" "Regulation of HSF1-mediated heat shock response; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Early Events; Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "1.147" "0.952" "1.174" "1.280" "1.117" "1.088" "0.788" "1.176" "6.708" "103.9" "119.2" "98.9" "122.0" "133.0" "116.1" "113.1" "81.9" "122.3" "697.3" "" "" "" "" "" "" "" "" "" "" "62.2" "62.0" "54.8" "57.3" "61.7" "59.4" "52.6" "36.8" "66.3" "697.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7333180136300150104" "False" "High" "IsMasterProtein" "Q96S44" "EKC/KEOPS complex subunit TP53RK OS=Homo sapiens OX=9606 GN=TP53RK PE=1 SV=2" "0.000" "False" "25.402" "26" "6" "11" "6" "253" "28.1" "9.54" "30.32" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf06293" "112858" "ENSG00000172315" "TP53RK" "B3KU44; hsa:112858; Q3T977; Q5JZ01; Q6NZ60; Q96FM7; Q96S44; Q9NQE6" "" "tRNA modification in the nucleus and cytosol; Regulation of TP53 Activity through Phosphorylation" "2" "0" "1.010" "0.928" "1.049" "0.987" "0.992" "0.952" "1.050" "0.982" "0.743" "892.9" "902.1" "828.4" "936.3" "881.2" "885.4" "849.8" "937.6" "876.8" "663.4" "" "" "" "" "" "" "" "" "" "" "534.3" "468.8" "458.8" "439.6" "408.4" "453.3" "395.1" "420.9" "475.7" "663.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-700726988884900620" "False" "High" "IsMasterProtein" "Q9BQ61" "Telomerase RNA component interacting RNase OS=Homo sapiens OX=9606 GN=TRIR PE=1 SV=1" "0.000" "False" "25.338" "25" "4" "15" "4" "176" "18.4" "9.44" "42.86" "4" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "" "79002" "ENSG00000123144" "TRIR" "hsa:79002; Q9BQ61" "" "" "0" "0" "0.939" "0.908" "0.940" "0.963" "0.949" "1.138" "1.121" "0.927" "0.497" "770.7" "723.9" "699.4" "724.7" "742.2" "731.4" "877.2" "864.2" "714.3" "382.8" "" "" "" "" "" "" "" "" "" "" "461.2" "376.2" "387.3" "340.2" "344.0" "374.4" "407.9" "388.0" "387.5" "382.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6603036499622523787" "False" "High" "IsMasterProtein" "Q9Y2S7" "Polymerase delta-interacting protein 2 OS=Homo sapiens OX=9606 GN=POLDIP2 PE=1 SV=1" "0.000" "False" "25.247" "24" "8" "10" "8" "368" "42.0" "8.63" "19.32" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf04379, Pf08755" "26073" "ENSG00000004142" "POLDIP2" "B2R846; hsa:26073; Q96JE4; Q9Y2S7" "" "" "0" "0" "1.168" "0.978" "1.113" "1.097" "1.143" "1.145" "0.952" "1.193" "1.464" "199.3" "232.7" "195.0" "221.9" "218.6" "227.7" "228.2" "189.6" "237.7" "291.8" "" "" "" "" "" "" "" "" "" "" "119.3" "120.9" "108.0" "104.2" "101.3" "116.6" "106.1" "85.1" "129.0" "291.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7242737941757580841" "False" "High" "IsMasterProtein" "P54105" "Methylosome subunit pICln OS=Homo sapiens OX=9606 GN=CLNS1A PE=1 SV=1" "0.000" "False" "25.226" "28" "4" "5" "4" "237" "26.2" "4.11" "15.14" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf03517" "1207" "ENSG00000074201" "CLNS1A" "B2RCS9; hsa:1207; P54105; Q0VDK6; Q9NRD2; Q9NRD3" "" "snRNP Assembly" "1" "0" "0.837" "0.825" "0.807" "0.886" "0.795" "0.866" "0.948" "0.927" "0.666" "184.2" "154.2" "152.0" "148.6" "163.2" "146.4" "159.4" "174.7" "170.8" "122.7" "" "" "" "" "" "" "" "" "" "" "110.2" "80.1" "84.2" "69.7" "75.6" "74.9" "74.1" "78.4" "92.7" "122.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3295496481374294049" "False" "High" "IsMasterProtein" "Q9UHD9" "Ubiquilin-2 OS=Homo sapiens OX=9606 GN=UBQLN2 PE=1 SV=2" "0.000" "False" "25.178" "16" "6" "16" "2" "624" "65.7" "5.22" "33.79" "6" "cell organization and biogenesis;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "29978" "ENSG00000188021" "UBQLN2" "hsa:29978; O94798; Q5D027; Q9H3W6; Q9HAZ4; Q9UHD9" "" "Cargo recognition for clathrin-mediated endocytosis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6123043622142940735" "False" "High" "IsMasterProtein" "P55145" "Mesencephalic astrocyte-derived neurotrophic factor OS=Homo sapiens OX=9606 GN=MANF PE=1 SV=3" "0.000" "False" "25.167" "25" "5" "8" "5" "182" "20.7" "8.69" "25.63" "5" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf10208, Pf20145" "7873" "ENSG00000145050" "MANF" "hsa:7873; P55145; Q14CX4; Q86U67; Q96IS4" "Orexin receptor pathway" "Platelet degranulation" "2" "0" "1.071" "1.032" "0.987" "1.109" "1.100" "1.189" "1.166" "1.063" "0.514" "838.9" "898.4" "865.9" "827.8" "930.3" "923.1" "997.4" "978.2" "892.0" "431.4" "" "" "" "" "" "" "" "" "" "" "502.1" "466.9" "479.5" "388.6" "431.2" "472.6" "463.7" "439.2" "484.0" "431.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3283541064302857350" "False" "High" "IsMasterProtein" "O75533" "Splicing factor 3B subunit 1 OS=Homo sapiens OX=9606 GN=SF3B1 PE=1 SV=3" "0.000" "False" "25.151" "7" "8" "10" "8" "1304" "145.7" "7.09" "17.87" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08920" "23451" "ENSG00000115524" "SF3B1" "E9PCH3; hsa:23451; O75533" "mRNA processing; 10q11.21q11.23 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "5" "0" "1.107" "1.202" "1.248" "1.130" "1.068" "1.116" "1.037" "1.173" "1.450" "143.1" "158.5" "172.0" "178.6" "161.8" "152.9" "159.7" "148.4" "167.9" "207.4" "" "" "" "" "" "" "" "" "" "" "85.6" "82.3" "95.2" "83.9" "75.0" "78.3" "74.2" "66.6" "91.1" "207.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6332903783671194577" "False" "High" "IsMasterProtein" "P62070" "Ras-related protein R-Ras2 OS=Homo sapiens OX=9606 GN=RRAS2 PE=1 SV=1" "0.000" "False" "25.134" "32" "6" "8" "6" "204" "23.4" "6.01" "21.01" "6" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf00071" "22800" "ENSG00000133818" "RRAS2" "B2R9Z3; B7Z5Z2; B7Z6C4; B7Z7H6; hsa:22800; P17082; P62070" "MAPK signaling pathway; Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGFR tyrosine kinase inhibitor resistance; Regulation of actin cytoskeleton" "RND1 GTPase cycle" "6" "0" "1.131" "0.867" "0.961" "1.072" "1.013" "0.932" "1.162" "0.960" "0.486" "172.6" "195.2" "149.7" "165.9" "185.1" "174.8" "160.9" "200.7" "165.7" "84.0" "" "" "" "" "" "" "" "" "" "" "103.3" "101.4" "82.9" "77.9" "85.8" "89.5" "74.8" "90.1" "89.9" "84.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2337219862284108106" "False" "High" "IsMasterProtein" "Q9Y262" "Eukaryotic translation initiation factor 3 subunit L OS=Homo sapiens OX=9606 GN=EIF3L PE=1 SV=1" "0.000" "False" "25.114" "13" "7" "10" "7" "564" "66.7" "6.34" "26.34" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf10255" "51386" "ENSG00000100129" "EIF3L" "B2RDG6; B4DYB2; G8JLH4; hsa:51386; Q53HQ1; Q53HT4; Q5QTR1; Q5TI15; Q6ICD2; Q9Y262" "" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "6" "0" "1.014" "0.893" "1.084" "1.047" "0.901" "0.997" "1.011" "1.009" "0.726" "538.5" "545.8" "480.8" "583.8" "563.6" "485.4" "537.1" "544.6" "543.5" "391.0" "" "" "" "" "" "" "" "" "" "" "322.2" "283.7" "266.3" "274.1" "261.2" "248.5" "249.7" "244.5" "294.9" "391.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5911471042018297925" "False" "High" "IsMasterProtein" "Q8ND56" "Protein LSM14 homolog A OS=Homo sapiens OX=9606 GN=LSM14A PE=1 SV=3" "0.000" "False" "25.057" "18" "7" "8" "7" "463" "50.5" "9.52" "23.53" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "nucleic acid binding activity" "Pf09532, Pf12701" "26065" "ENSG00000257103; ENSG00000262860" "LSM14A" "B4DTG6; hsa:26065; Q76LX7; Q8ND56; Q96AR3; Q96K73; Q96SN5; Q9UFR3" "" "" "0" "0" "1.015" "0.951" "1.081" "1.140" "1.007" "1.205" "1.122" "1.014" "1.236" "386.4" "392.3" "367.4" "417.6" "440.5" "389.0" "465.5" "433.5" "391.8" "477.5" "" "" "" "" "" "" "" "" "" "" "231.2" "203.9" "203.4" "196.1" "204.2" "199.1" "216.4" "194.6" "212.6" "477.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1150602487247342071" "False" "High" "IsMasterProtein" "Q92890" "Ubiquitin recognition factor in ER-associated degradation protein 1 OS=Homo sapiens OX=9606 GN=UFD1 PE=1 SV=3" "0.000" "False" "25.017" "21" "5" "13" "5" "307" "34.5" "6.70" "37.87" "5" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03152" "7353" "ENSG00000070010" "UFD1" "A8MW31; hsa:7353; Q92890; Q9Y5N0" "22q11.2 copy number variation syndrome" "Ub-specific processing proteases; Neddylation; KEAP1-NFE2L2 pathway; Translesion Synthesis by POLH" "5" "0" "1.029" "0.993" "0.994" "1.163" "0.989" "1.238" "1.087" "1.263" "0.784" "432.6" "445.2" "429.5" "430.2" "503.1" "427.9" "535.4" "470.3" "546.6" "339.0" "" "" "" "" "" "" "" "" "" "" "258.9" "231.4" "237.8" "202.0" "233.2" "219.0" "248.9" "211.2" "296.5" "339.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2355880035621835112" "False" "High" "IsMasterProtein" "O15067" "Phosphoribosylformylglycinamidine synthase OS=Homo sapiens OX=9606 GN=PFAS PE=1 SV=4" "0.000" "False" "25.000" "8" "10" "14" "10" "1338" "144.6" "5.76" "32.70" "10" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf02769, Pf13507, Pf18072, Pf18076" "5198" "ENSG00000178921" "PFAS" "A6H8V8; hsa:5198; O15067" "" "Purine ribonucleoside monophosphate biosynthesis" "1" "0" "1.009" "0.915" "1.105" "1.082" "0.903" "1.122" "0.728" "1.066" "3.987" "696.4" "702.4" "636.8" "769.4" "753.2" "628.8" "781.0" "506.8" "742.0" "2776.2" "" "" "" "" "" "" "" "" "" "" "416.7" "365.0" "352.7" "361.2" "349.1" "321.9" "363.2" "227.5" "402.6" "2776.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-65550439794871329" "False" "High" "IsMasterProtein" "Q9BXS5" "AP-1 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP1M1 PE=1 SV=3" "0.000" "False" "24.991" "17" "7" "11" "7" "423" "48.6" "7.30" "30.71" "7" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00928, Pf01217" "8907" "ENSG00000072958" "AP1M1" "hsa:8907; Q4TTY5; Q9BXS5" "" "Neutrophil degranulation; MHC class II antigen presentation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "5" "0" "1.111" "1.039" "1.016" "1.037" "1.133" "1.059" "1.091" "1.126" "1.999" "684.5" "760.5" "711.0" "695.4" "709.8" "775.9" "724.6" "746.9" "771.1" "1368.6" "" "" "" "" "" "" "" "" "" "" "409.7" "395.2" "393.7" "326.5" "329.0" "397.2" "336.9" "335.3" "418.3" "1368.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4476528208765438767" "False" "High" "IsMasterProtein" "Q9Y5S9" "RNA-binding protein 8A OS=Homo sapiens OX=9606 GN=RBM8A PE=1 SV=1" "0.000" "False" "24.971" "32" "6" "13" "6" "174" "19.9" "5.72" "33.90" "6" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "9939" "ENSG00000265241" "RBM8A" "B3KQI9; hsa:9939; Q6FHD1; Q6IQ40; Q9GZX8; Q9NZI4; Q9Y5S9" "" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; RNA Polymerase II Transcription Termination; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing" "6" "0" "1.020" "1.116" "0.952" "1.044" "1.113" "0.970" "0.991" "1.094" "0.989" "646.0" "658.8" "720.8" "614.8" "674.4" "718.7" "626.4" "640.1" "706.7" "638.6" "" "" "" "" "" "" "" "" "" "" "386.6" "342.4" "399.2" "288.6" "312.6" "367.9" "291.3" "287.4" "383.4" "638.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7338451157516248926" "False" "High" "IsMasterProtein" "Q96IZ0" "PRKC apoptosis WT1 regulator protein OS=Homo sapiens OX=9606 GN=PAWR PE=1 SV=1" "0.000" "False" "24.910" "21" "6" "12" "6" "340" "36.5" "5.41" "28.73" "6" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "5074" "ENSG00000177425" "PAWR" "hsa:5074; O75796; Q6FHY9; Q8N700; Q96IZ0" "" "" "0" "0" "1.006" "1.019" "1.069" "1.096" "1.010" "1.124" "1.082" "0.929" "0.672" "197.0" "198.2" "200.7" "210.5" "215.9" "199.0" "221.4" "213.2" "182.9" "132.5" "" "" "" "" "" "" "" "" "" "" "117.9" "103.0" "111.1" "98.8" "100.1" "101.9" "102.9" "95.7" "99.2" "132.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1687384969150092260" "False" "High" "IsMasterProtein" "Q96B97" "SH3 domain-containing kinase-binding protein 1 OS=Homo sapiens OX=9606 GN=SH3KBP1 PE=1 SV=2" "0.000" "False" "24.898" "13" "7" "8" "7" "665" "73.1" "6.62" "19.96" "7" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf14604" "30011" "ENSG00000147010" "SH3KBP1" "B7Z1D5; hsa:30011; Q5JPT4; Q5JPT5; Q8IWX6; Q8IX98; Q96B97; Q96RN4; Q9NYR0" "EGF/EGFR signaling pathway" "Potential therapeutics for SARS; Cargo recognition for clathrin-mediated endocytosis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Reelin signalling pathway" "9" "0" "1.129" "1.308" "1.226" "1.091" "1.137" "1.138" "1.018" "1.295" "2.349" "147.0" "166.0" "192.3" "180.3" "160.4" "167.2" "167.3" "149.6" "190.4" "345.4" "" "" "" "" "" "" "" "" "" "" "88.0" "86.3" "106.5" "84.6" "74.3" "85.6" "77.8" "67.2" "103.3" "345.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5379927886480691395" "False" "High" "IsMasterProtein" "O95456" "Proteasome assembly chaperone 1 OS=Homo sapiens OX=9606 GN=PSMG1 PE=1 SV=1" "0.000" "False" "24.848" "19" "5" "9" "5" "288" "32.8" "7.17" "29.20" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf16094" "8624" "ENSG00000183527" "PSMG1" "B5BUN2; hsa:8624; O95456; Q6FHA3; Q6FHD3; Q6S713" "" "" "0" "0" "0.991" "0.919" "0.983" "1.038" "1.031" "0.986" "1.017" "1.051" "0.839" "645.1" "639.1" "592.8" "634.1" "669.6" "665.4" "636.1" "656.2" "678.3" "541.1" "" "" "" "" "" "" "" "" "" "" "386.1" "332.1" "328.3" "297.7" "310.4" "340.7" "295.8" "294.6" "368.0" "541.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4853611610042411436" "False" "High" "IsMasterProtein" "Q04760" "Lactoylglutathione lyase OS=Homo sapiens OX=9606 GN=GLO1 PE=1 SV=4" "0.000" "False" "24.842" "32" "7" "31" "7" "184" "20.8" "5.31" "70.29" "7" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00903" "2739" "ENSG00000124767" "GLO1" "B2R6P7; B4DDV0; hsa:2739; P78375; Q04760; Q59EL0; Q5TZW3; Q96FC0; Q96J41" "" "Pyruvate metabolism" "1" "0" "0.977" "0.920" "0.920" "0.999" "0.914" "0.976" "0.938" "0.913" "0.476" "1939.8" "1894.6" "1784.3" "1784.6" "1937.7" "1772.9" "1893.2" "1819.8" "1771.2" "922.7" "" "" "" "" "" "" "" "" "" "" "1160.8" "984.6" "988.1" "837.8" "898.2" "907.6" "880.3" "817.0" "960.9" "922.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7902692244369353681" "False" "High" "IsMasterProtein" "Q9Y6G9" "Cytoplasmic dynein 1 light intermediate chain 1 OS=Homo sapiens OX=9606 GN=DYNC1LI1 PE=1 SV=3" "0.000" "False" "24.752" "18" "8" "9" "8" "523" "56.5" "6.42" "23.32" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05783" "51143" "ENSG00000144635" "DYNC1LI1" "A2RRG7; hsa:51143; Q53HC8; Q53HK7; Q9Y6G9" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; MHC class II antigen presentation; Neutrophil degranulation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy" "16" "0" "1.095" "1.067" "1.088" "0.986" "1.090" "0.982" "0.636" "1.048" "4.089" "188.8" "206.8" "201.5" "205.5" "186.2" "205.7" "185.5" "120.2" "198.0" "772.3" "" "" "" "" "" "" "" "" "" "" "113.0" "107.5" "111.6" "96.5" "86.3" "105.3" "86.3" "53.9" "107.4" "772.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2020319621841403457" "False" "High" "IsMasterProtein" "P07741" "Adenine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=APRT PE=1 SV=2" "0.000" "False" "24.746" "33" "7" "37" "7" "180" "19.6" "6.02" "84.54" "7" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00156" "353" "ENSG00000198931" "APRT" "G5E9J2; hsa:353; P07741; Q3KP55; Q68DF9" "" "Neutrophil degranulation; Purine salvage; Defective APRT disrupts adenine salvage" "3" "0" "0.986" "0.952" "1.028" "0.962" "1.031" "1.024" "1.115" "1.043" "0.582" "2459.1" "2423.6" "2339.9" "2528.0" "2365.6" "2535.5" "2519.2" "2740.9" "2563.6" "1431.5" "" "" "" "" "" "" "" "" "" "" "1471.6" "1259.5" "1295.8" "1186.9" "1096.5" "1298.0" "1171.4" "1230.5" "1390.9" "1431.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5757828644476711483" "False" "High" "IsMasterProtein" "Q9NXR1" "Nuclear distribution protein nudE homolog 1 OS=Homo sapiens OX=9606 GN=NDE1 PE=1 SV=3" "0.000" "False" "24.719" "22" "7" "8" "7" "335" "37.7" "5.15" "23.63" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04880" "54820" "ENSG00000072864; ENSG00000275911" "NDE1" "hsa:54820; Q49AQ2; Q9NXR1" "" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "13" "0" "1.034" "0.993" "0.973" "1.128" "1.077" "1.146" "1.069" "1.010" "0.896" "269.7" "278.9" "267.9" "262.5" "304.2" "290.5" "309.2" "288.4" "272.4" "241.7" "" "" "" "" "" "" "" "" "" "" "161.4" "144.9" "148.4" "123.3" "141.0" "148.7" "143.8" "129.5" "147.8" "241.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6174880606405183757" "False" "High" "IsMasterProtein" "P56545" "C-terminal-binding protein 2 OS=Homo sapiens OX=9606 GN=CTBP2 PE=1 SV=1" "0.000" "False" "24.685" "18" "8" "20" "4" "445" "48.9" "6.95" "50.65" "8" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00389, Pf02826" "1488" "ENSG00000175029" "CTBP2" "A8K2X5; D3DRF5; hsa:1488; O43449; P56545; Q5SQP7; Q69YI3; Q86SV0; Q8IY44; Q9H2T8" "Neural crest differentiation; Notch signaling; Mesodermal commitment pathway; Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Pleural mesothelioma" "Repression of WNT target genes; Signaling by TCF7L2 mutants" "11" "0" "0.980" "0.848" "0.919" "0.962" "0.940" "1.065" "0.948" "0.945" "0.811" "369.8" "362.5" "313.5" "339.8" "355.7" "347.6" "393.9" "350.4" "349.3" "300.0" "" "" "" "" "" "" "" "" "" "" "221.3" "188.4" "173.6" "159.5" "164.9" "177.9" "183.2" "157.3" "189.5" "300.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1017068245716453317" "False" "High" "IsMasterProtein" "O95782" "AP-2 complex subunit alpha-1 OS=Homo sapiens OX=9606 GN=AP2A1 PE=1 SV=3" "0.000" "False" "24.661" "9" "9" "12" "9" "977" "107.5" "7.03" "23.86" "9" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01602, Pf02296, Pf02883" "160" "ENSG00000196961" "AP2A1" "hsa:160; O95782; Q96CI7; Q96PP6; Q96PP7; Q9H070" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission; Cell lineage map for neuronal differentiation" "MHC class II antigen presentation; Potential therapeutics for SARS; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Trafficking of GluR2-containing AMPA receptors; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "21" "0" "1.018" "1.089" "1.195" "1.108" "1.028" "1.149" "1.088" "1.082" "1.224" "297.0" "302.3" "323.5" "354.8" "329.0" "305.2" "341.4" "323.2" "321.4" "363.5" "" "" "" "" "" "" "" "" "" "" "177.7" "157.1" "179.2" "166.6" "152.5" "156.2" "158.7" "145.1" "174.4" "363.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2776993726351284183" "False" "High" "IsMasterProtein" "Q9BVJ6" "U3 small nucleolar RNA-associated protein 14 homolog A OS=Homo sapiens OX=9606 GN=UTP14A PE=1 SV=1" "0.000" "False" "24.643" "9" "5" "6" "5" "771" "87.9" "7.87" "19.83" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf04615" "10813" "ENSG00000156697" "UTP14A" "A8K7A3; A8MVQ1; B4DQ08; E9PEL7; hsa:10813; Q5JYF1; Q9BVJ6" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.119" "0.969" "1.090" "1.090" "0.948" "1.088" "1.042" "0.906" "0.554" "217.6" "243.6" "210.9" "237.3" "237.2" "206.4" "236.6" "226.8" "197.0" "120.5" "" "" "" "" "" "" "" "" "" "" "130.2" "126.6" "116.8" "111.4" "110.0" "105.7" "110.0" "101.8" "106.9" "120.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8716615983158352243" "False" "High" "IsMasterProtein" "P27695" "DNA repair nuclease/redox regulator APEX1 OS=Homo sapiens OX=9606 GN=APEX1 PE=1 SV=2" "0.000" "False" "24.584" "19" "6" "8" "6" "318" "35.5" "8.12" "22.11" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372" "328" "ENSG00000100823; ENSG00000291796" "APEX1" "hsa:328; P27695; Q969L5; Q99775" "Thyroid stimulating hormone (TSH) signaling pathway; Spinal cord injury; Base excision repair; DNA repair pathways, full network" "Displacement of DNA glycosylase by APEX1; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway" "10" "0" "0.947" "1.015" "0.957" "1.122" "0.955" "1.034" "0.316" "0.890" "8.404" "208.6" "197.6" "211.7" "199.6" "234.0" "199.2" "215.6" "65.8" "185.5" "1752.7" "" "" "" "" "" "" "" "" "" "" "124.8" "102.7" "117.2" "93.7" "108.5" "102.0" "100.3" "29.5" "100.7" "1752.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6716088986514922399" "False" "High" "IsMasterProtein" "Q13617" "Cullin-2 OS=Homo sapiens OX=9606 GN=CUL2 PE=1 SV=2" "0.000" "False" "24.563" "12" "8" "15" "8" "745" "86.9" "6.92" "36.43" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8453" "ENSG00000108094" "CUL2" "B3KT95; B7Z6K8; D3DRY6; G3V1S2; hsa:8453; O00200; Q13617; Q5T2B6; Q9UNF9" "Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2" "Neddylation; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha" "6" "0" "1.072" "1.064" "1.041" "1.006" "1.235" "0.985" "1.181" "1.074" "0.890" "718.0" "769.8" "764.1" "747.3" "722.2" "886.8" "707.0" "847.9" "771.0" "638.6" "" "" "" "" "" "" "" "" "" "" "429.7" "400.0" "423.2" "350.8" "334.8" "454.0" "328.8" "380.7" "418.3" "638.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4078763853778873139" "False" "High" "IsMasterProtein" "O95816" "BAG family molecular chaperone regulator 2 OS=Homo sapiens OX=9606 GN=BAG2 PE=1 SV=1" "0.000" "False" "24.561" "26" "6" "8" "6" "211" "23.8" "6.70" "26.23" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "" "9532" "ENSG00000112208" "BAG2" "B4DXE2; hsa:9532; O95816; Q08AS9; Q6FID0" "Pleural mesothelioma" "Regulation of HSF1-mediated heat shock response" "2" "0" "1.067" "1.125" "1.068" "1.091" "1.018" "1.090" "0.970" "1.239" "1.804" "718.2" "766.6" "807.8" "766.9" "783.6" "731.4" "782.9" "696.6" "890.0" "1295.6" "" "" "" "" "" "" "" "" "" "" "429.8" "398.4" "447.3" "360.0" "363.2" "374.4" "364.0" "312.7" "482.8" "1295.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3428754804967895147" "False" "High" "IsMasterProtein" "O95989" "Diphosphoinositol polyphosphate phosphohydrolase 1 OS=Homo sapiens OX=9606 GN=NUDT3 PE=1 SV=1" "0.000" "False" "24.558" "23" "4" "9" "3" "172" "19.5" "6.34" "29.83" "4" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00293" "11165" "ENSG00000272325" "NUDT3" "B2R8N4; hsa:11165; O95989" "" "Synthesis of pyrophosphates in the cytosol" "1" "0" "1.000" "1.008" "1.073" "1.021" "1.011" "0.946" "1.069" "1.006" "0.724" "665.1" "665.4" "670.4" "713.5" "678.9" "672.4" "629.0" "710.8" "669.2" "481.6" "" "" "" "" "" "" "" "" "" "" "398.0" "345.8" "371.3" "335.0" "314.7" "344.2" "292.5" "319.1" "363.1" "481.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-566189082840404496" "False" "High" "IsMasterProtein" "Q8WVM7" "Cohesin subunit SA-1 OS=Homo sapiens OX=9606 GN=STAG1 PE=1 SV=3" "0.000" "False" "24.546" "6" "8" "9" "5" "1258" "144.3" "5.59" "21.53" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08514, Pf21581" "10274" "ENSG00000118007" "STAG1" "hsa:10274; O00539; Q6P275; Q8WVM7" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; 10q22q23 copy number variation" "Meiotic synapsis; Estrogen-dependent gene expression; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "10" "0" "1.091" "0.772" "0.935" "1.001" "0.896" "0.866" "0.918" "0.853" "1.268" "131.7" "143.6" "101.6" "123.1" "131.9" "118.0" "114.1" "120.9" "112.3" "167.0" "" "" "" "" "" "" "" "" "" "" "78.8" "74.6" "56.3" "57.8" "61.1" "60.4" "53.0" "54.3" "60.9" "167.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1075701088619798442" "False" "High" "IsMasterProtein" "Q96BZ8" "Leukocyte receptor cluster member 1 OS=Homo sapiens OX=9606 GN=LENG1 PE=1 SV=2" "0.000" "False" "24.490" "19" "6" "10" "6" "264" "30.5" "9.80" "25.25" "6" "" "nucleus" "" "Pf10197" "79165" "ENSG00000105617; ENSG00000275935; ENSG00000276628; ENSG00000276774; ENSG00000276959; ENSG00000277457; ENSG00000277808; ENSG00000278257; ENSG00000278426; ENSG00000278516" "LENG1" "hsa:79165; Q96BZ8; Q9HCU7" "" "mRNA Splicing - Major Pathway" "1" "0" "1.046" "0.982" "0.994" "1.148" "1.076" "1.085" "1.168" "0.994" "0.583" "392.0" "410.0" "384.9" "389.7" "450.1" "421.7" "425.4" "457.9" "389.8" "228.5" "" "" "" "" "" "" "" "" "" "" "234.6" "213.1" "213.2" "182.9" "208.6" "215.9" "197.8" "205.6" "211.5" "228.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5964794776079938030" "False" "High" "IsMasterProtein" "P56537" "Eukaryotic translation initiation factor 6 OS=Homo sapiens OX=9606 GN=EIF6 PE=1 SV=1" "0.000" "False" "24.490" "34" "6" "15" "6" "245" "26.6" "4.68" "25.62" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01912" "3692" "ENSG00000242372" "EIF6" "B7ZBG9; hsa:3692; P56537; Q6IBN8; Q96TD5" "Translation factors; Genetic causes of porto-sinusoidal vascular disease" "" "2" "0" "1.021" "1.043" "1.100" "1.101" "1.070" "1.018" "1.211" "1.109" "0.744" "288.5" "294.6" "300.8" "317.3" "317.7" "308.7" "293.8" "349.5" "319.8" "214.6" "" "" "" "" "" "" "" "" "" "" "172.6" "153.1" "166.6" "149.0" "147.3" "158.0" "136.6" "156.9" "173.5" "214.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1505271825198651647" "False" "High" "IsMasterProtein" "P41236" "Protein phosphatase inhibitor 2 OS=Homo sapiens OX=9606 GN=PPP1R2 PE=1 SV=2" "0.000" "False" "24.476" "24" "4" "8" "4" "205" "23.0" "4.74" "29.79" "4" "other metabolic processes;other biological processes" "" "enzyme regulator activity;other molecular function" "Pf04979" "5504" "ENSG00000184203" "PPP1R2" "hsa:5504; P41236" "" "" "0" "0" "0.968" "0.946" "0.918" "1.074" "1.048" "1.130" "1.124" "0.993" "0.518" "714.5" "691.8" "675.7" "655.8" "767.7" "748.6" "807.1" "803.0" "709.3" "370.1" "" "" "" "" "" "" "" "" "" "" "427.6" "359.5" "374.2" "307.9" "355.8" "383.2" "375.3" "360.5" "384.8" "370.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4685450292699183556" "False" "High" "IsMasterProtein" "P43246" "DNA mismatch repair protein Msh2 OS=Homo sapiens OX=9606 GN=MSH2 PE=1 SV=1" "0.000" "False" "24.392" "7" "7" "7" "7" "934" "104.7" "5.77" "20.88" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00488, Pf01624, Pf05188, Pf05190, Pf05192" "4436" "ENSG00000095002" "MSH2" "B4E2Z2; hsa:4436; O75488; P43246" "RAC1/PAK1/p38/MMP2 pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ciliary landscape; DNA repair pathways, full network; p53 transcriptional gene network; DNA mismatch repair" "TP53 Regulates Transcription of DNA Repair Genes; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6" "12" "0" "1.234" "1.433" "1.411" "1.486" "1.397" "1.301" "0.877" "1.369" "7.104" "127.6" "157.5" "182.8" "180.1" "189.7" "178.4" "166.1" "111.9" "174.8" "906.7" "" "" "" "" "" "" "" "" "" "" "76.4" "81.8" "101.2" "84.6" "87.9" "91.3" "77.2" "50.3" "94.8" "906.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1130211750852848646" "False" "High" "IsMasterProtein" "Q13404" "Ubiquitin-conjugating enzyme E2 variant 1 OS=Homo sapiens OX=9606 GN=UBE2V1 PE=1 SV=2" "0.000" "False" "24.344" "50" "7" "36" "3" "147" "16.5" "7.93" "72.69" "7" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00179" "387522; 7335" "ENSG00000244687" "UBE2V1" "E1P629; hsa:387522; hsa:7335; Q13403; Q13404; Q13532; Q5TGE0; Q5TGE3; Q96H34; Q9GZT0; Q9GZW1; Q9H4J3; Q9H4J4; Q9UKL1; Q9UM48; Q9UM49; Q9UM50" "IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway" "Downstream TCR signaling; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; Aggrephagy; SARS-CoV-2 activates/modulates innate and adaptive immune responses; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "19" "3" "1.001" "0.968" "1.004" "1.041" "1.034" "1.055" "1.019" "1.007" "0.675" "2139.1" "2140.5" "2071.6" "2147.7" "2227.3" "2211.5" "2255.8" "2180.0" "2153.9" "1443.8" "" "" "" "" "" "" "" "" "" "" "1280.1" "1112.3" "1147.2" "1008.3" "1032.4" "1132.1" "1048.9" "978.7" "1168.6" "1443.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6062730820723703914" "False" "High" "IsMasterProtein" "P82094" "TATA element modulatory factor OS=Homo sapiens OX=9606 GN=TMF1 PE=1 SV=2" "0.000" "False" "24.324" "9" "8" "8" "8" "1093" "122.8" "4.92" "18.81" "8" "cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf12325, Pf12329" "7110" "ENSG00000144747" "TMF1" "B7ZLJ2; hsa:7110; P82094; Q17R87; Q59GK0" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "0.980" "0.857" "0.898" "1.077" "0.809" "1.113" "1.033" "0.994" "0.568" "194.2" "190.4" "166.6" "174.3" "209.2" "157.1" "216.2" "200.6" "193.0" "110.3" "" "" "" "" "" "" "" "" "" "" "116.2" "98.9" "92.2" "81.8" "97.0" "80.4" "100.5" "90.1" "104.7" "110.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5197563919464376950" "False" "High" "IsMasterProtein" "Q9BTC0" "Death-inducer obliterator 1 OS=Homo sapiens OX=9606 GN=DIDO1 PE=1 SV=5" "0.000" "False" "24.315" "4" "8" "9" "8" "2240" "243.7" "7.88" "23.17" "8" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00628, Pf07500, Pf07744" "11083" "ENSG00000101191" "DIDO1" "A8MY65; B9EH82; E1P5I1; hsa:11083; O15043; Q3ZTL7; Q3ZTL8; Q4VXS1; Q4VXS2; Q4VXV8; Q4VXV9; Q96D72; Q9BQW0; Q9BTC0; Q9BW03; Q9H4G6; Q9H4G7; Q9NTU8; Q9NUM8; Q9UFB6" "" "" "0" "0" "1.060" "1.002" "0.956" "1.029" "0.973" "1.149" "1.038" "0.994" "1.354" "329.6" "349.4" "330.3" "315.1" "339.3" "320.6" "378.8" "342.2" "327.7" "446.1" "" "" "" "" "" "" "" "" "" "" "197.3" "181.6" "182.9" "147.9" "157.3" "164.1" "176.1" "153.6" "177.8" "446.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174641781052764353" "False" "High" "IsMasterProtein" "Q9P2T1" "GMP reductase 2 OS=Homo sapiens OX=9606 GN=GMPR2 PE=1 SV=1" "0.000" "False" "24.313" "19" "7" "14" "7" "348" "37.9" "7.23" "38.22" "7" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00478" "51292" "ENSG00000100938; ENSG00000284752" "GMPR2" "D3DS66; hsa:51292; Q567T0; Q6IAJ8; Q86T14; Q9P2T1" "" "Purine salvage" "1" "0" "1.000" "0.951" "1.088" "1.045" "0.972" "0.966" "1.032" "1.005" "0.612" "789.9" "789.9" "750.8" "859.1" "825.5" "768.2" "762.7" "814.9" "793.7" "483.2" "" "" "" "" "" "" "" "" "" "" "472.7" "410.5" "415.8" "403.3" "382.6" "393.2" "354.7" "365.8" "430.6" "483.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8926098929249154387" "False" "High" "IsMasterProtein" "Q9NR28" "Diablo IAP-binding mitochondrial protein OS=Homo sapiens OX=9606 GN=DIABLO PE=1 SV=1" "0.000" "False" "24.279" "22" "5" "10" "5" "239" "27.1" "5.90" "27.96" "5" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion" "" "Pf09057" "56616" "ENSG00000184047" "DIABLO" "B2RDQ0; hsa:56616; Q6W3F3; Q96LV0; Q9BT11; Q9HAV6; Q9NR28" "Apoptosis modulation and signaling; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Apoptosis; Complement system in neuronal development and plasticity" "Regulation of the apoptosome activity; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Release of apoptotic factors from the mitochondria" "10" "0" "0.980" "0.909" "1.017" "1.161" "1.049" "1.096" "1.189" "1.192" "0.633" "600.9" "589.0" "546.2" "611.1" "697.8" "630.0" "658.7" "714.4" "716.5" "380.6" "" "" "" "" "" "" "" "" "" "" "359.6" "306.1" "302.5" "286.9" "323.5" "322.5" "306.3" "320.7" "388.7" "380.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9139942290346830630" "False" "High" "IsMasterProtein" "P30084" "Enoyl-CoA hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ECHS1 PE=1 SV=4" "0.000" "False" "24.273" "28" "7" "14" "7" "290" "31.4" "8.07" "31.54" "7" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00378" "1892" "ENSG00000127884" "ECHS1" "hsa:1892; O00739; P30084; Q5VWY1; Q96H54" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Ciliary landscape; Tryptophan metabolism" "Branched-chain amino acid catabolism; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA" "10" "0" "1.275" "1.037" "1.156" "1.273" "1.191" "1.208" "1.005" "1.016" "1.418" "283.4" "361.4" "294.1" "327.5" "360.8" "337.7" "342.4" "284.8" "288.0" "401.9" "" "" "" "" "" "" "" "" "" "" "169.6" "187.8" "162.8" "153.8" "167.3" "172.9" "159.2" "127.8" "156.3" "401.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4751284344252295029" "False" "High" "IsMasterProtein" "P06748" "Nucleophosmin OS=Homo sapiens OX=9606 GN=NPM1 PE=1 SV=2" "0.000" "False" "24.203" "20" "6" "42" "6" "294" "32.6" "4.78" "116.29" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function" "Pf03066, Pf16276" "4869" "ENSG00000181163" "NPM1" "A8K3N7; B5BU00; D3DQL6; hsa:4869; P06748; P08693; Q12826; Q13440; Q13441; Q14115; Q5EU94; Q5EU95; Q5EU96; Q5EU97; Q5EU98; Q5EU99; Q6V962; Q8WTW5; Q96AT6; Q96DC4; Q96EA5; Q9BYG9; Q9UDJ7" "" "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; PKR-mediated signaling; Nuclear import of Rev protein; Deposition of new CENPA-containing nucleosomes at the centromere; SUMOylation of transcription cofactors; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; Nuclear events stimulated by ALK signaling in cancer; SARS-CoV-1-host interactions" "10" "0" "0.867" "0.900" "0.711" "0.710" "0.685" "0.745" "0.544" "0.698" "1.703" "3223.7" "2794.2" "2899.8" "2293.6" "2289.4" "2208.1" "2401.6" "1752.5" "2251.3" "5488.5" "" "" "" "" "" "" "" "" "" "" "1929.2" "1452.1" "1605.8" "1076.8" "1061.2" "1130.4" "1116.7" "786.8" "1221.4" "5488.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8625862126903742140" "False" "High" "IsMasterProtein" "P48556" "26S proteasome non-ATPase regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMD8 PE=1 SV=2" "0.000" "False" "24.185" "18" "8" "19" "8" "350" "39.6" "9.70" "54.73" "8" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf10075" "5714" "ENSG00000099341" "PSMD8" "B4DX18; hsa:5714; P48556; Q6P1L7" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "Regulation of expression of SLITs and ROBOs; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "0.982" "0.878" "1.029" "0.964" "0.981" "1.052" "1.024" "0.992" "0.720" "1796.6" "1764.3" "1578.1" "1848.3" "1731.8" "1762.3" "1890.7" "1839.5" "1782.6" "1292.8" "" "" "" "" "" "" "" "" "" "" "1075.2" "916.9" "873.9" "867.7" "802.7" "902.2" "879.1" "825.8" "967.1" "1292.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "960640284500961057" "False" "High" "IsMasterProtein" "Q13426" "DNA repair protein XRCC4 OS=Homo sapiens OX=9606 GN=XRCC4 PE=1 SV=2" "0.000" "False" "24.173" "25" "8" "14" "8" "336" "38.3" "4.98" "27.17" "8" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06632" "7518" "ENSG00000152422" "XRCC4" "A8K3X4; hsa:7518; Q13426; Q9BS72; Q9UP94" "Non-homologous end joining; Male infertility; DNA repair pathways, full network; Primary ovarian insufficiency" "SUMOylation of DNA damage response and repair proteins; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation" "7" "0" "1.110" "1.105" "0.994" "1.152" "1.165" "1.112" "1.199" "1.114" "0.698" "283.8" "314.8" "313.7" "282.0" "327.0" "330.5" "315.6" "340.3" "316.2" "198.1" "" "" "" "" "" "" "" "" "" "" "169.8" "163.6" "173.7" "132.4" "151.6" "169.2" "146.8" "152.8" "171.6" "198.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8211975543562738760" "False" "High" "IsMasterProtein" "P13984" "General transcription factor IIF subunit 2 OS=Homo sapiens OX=9606 GN=GTF2F2 PE=1 SV=2" "0.000" "False" "24.153" "25" "7" "16" "7" "249" "28.4" "9.23" "46.55" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf02270, Pf17683" "2963" "ENSG00000188342" "GTF2F2" "A6NNS5; hsa:2963; P13984; Q5W0H3" "Eukaryotic transcription initiation" "Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Estrogen-dependent gene expression; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "33" "0" "0.989" "0.993" "0.986" "1.000" "1.047" "0.958" "0.959" "0.993" "0.975" "1424.8" "1409.0" "1415.5" "1404.7" "1424.4" "1492.1" "1365.2" "1367.0" "1415.1" "1389.3" "" "" "" "" "" "" "" "" "" "" "852.7" "732.2" "783.9" "659.5" "660.2" "763.8" "634.8" "613.7" "767.7" "1389.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3324031393637842436" "False" "High" "IsMasterProtein" "P49458" "Signal recognition particle 9 kDa protein OS=Homo sapiens OX=9606 GN=SRP9 PE=1 SV=2" "0.000" "False" "24.110" "50" "5" "24" "5" "86" "10.1" "7.97" "57.59" "5" "other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf05486" "6726" "ENSG00000143742" "SRP9" "A8K0N0; hsa:6726; P49458; Q6NVX0; Q8WTW0" "" "SRP-dependent cotranslational protein targeting to membrane" "1" "0" "0.945" "0.914" "0.863" "0.921" "0.960" "0.929" "0.880" "0.845" "0.544" "2015.9" "1904.9" "1841.9" "1740.4" "1857.2" "1934.8" "1873.5" "1773.9" "1703.1" "1095.8" "" "" "" "" "" "" "" "" "" "" "1206.4" "989.9" "1020.0" "817.1" "860.9" "990.5" "871.1" "796.4" "924.0" "1095.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6656538987652310722" "False" "High" "IsMasterProtein" "Q86X29" "Lipolysis-stimulated lipoprotein receptor OS=Homo sapiens OX=9606 GN=LSR PE=1 SV=4" "0.000" "False" "24.109" "12" "7" "9" "7" "649" "71.4" "7.97" "22.12" "7" "cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "" "Pf05624" "51599" "ENSG00000105699" "LSR" "A6NDW3; B4DKL4; E9PHD4; hsa:51599; O00112; O00426; Q6ZT80; Q86X29; Q8NBM0; Q9BT33; Q9UQL3" "" "LDL clearance; VLDL clearance" "2" "0" "1.048" "0.915" "1.083" "1.165" "1.006" "1.086" "1.089" "1.061" "0.540" "257.9" "270.2" "236.0" "279.2" "300.4" "259.5" "280.1" "280.8" "273.6" "139.3" "" "" "" "" "" "" "" "" "" "" "154.3" "140.4" "130.7" "131.1" "139.3" "132.8" "130.2" "126.1" "148.4" "139.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1112180940687261840" "False" "High" "IsMasterProtein" "Q15185" "Prostaglandin E synthase 3 OS=Homo sapiens OX=9606 GN=PTGES3 PE=1 SV=1" "0.000" "False" "24.097" "24" "5" "21" "5" "160" "18.7" "4.54" "54.79" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04969" "10728" "ENSG00000110958" "PTGES3" "A8K7D0; B4DHP2; B4DP11; B4DP21; hsa:10728; Q15185; Q8WU70" "Aryl hydrocarbon receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Omega-6-fatty acids in senescence" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Potential therapeutics for SARS; Aryl hydrocarbon receptor signalling; Estrogen-dependent gene expression; Synthesis of Prostaglandins (PG) and Thromboxanes (TX); HSF1 activation; Attenuation phase" "12" "0" "1.060" "1.463" "0.984" "1.144" "1.007" "0.967" "0.576" "1.176" "4.893" "518.4" "549.6" "758.5" "510.2" "593.2" "522.1" "501.4" "298.5" "609.5" "2536.2" "" "" "" "" "" "" "" "" "" "" "310.2" "285.6" "420.0" "239.5" "275.0" "267.3" "233.2" "134.0" "330.7" "2536.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3384207672428186398" "False" "High" "IsMasterProtein" "Q8N335" "Glycerol-3-phosphate dehydrogenase 1-like protein OS=Homo sapiens OX=9606 GN=GPD1L PE=1 SV=1" "0.000" "False" "24.094" "23" "9" "9" "9" "351" "38.4" "7.02" "25.83" "9" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01210, Pf07479" "23171" "ENSG00000152642" "GPD1L" "A8K9U3; hsa:23171; Q14702; Q8N335; Q9BRM5" "Sudden infant death syndrome (SIDS) susceptibility pathways" "Synthesis of PA" "2" "0" "0.997" "0.959" "1.114" "1.082" "1.019" "1.024" "1.057" "1.031" "0.790" "710.0" "707.6" "681.1" "790.8" "768.6" "723.6" "726.7" "750.3" "732.2" "561.0" "" "" "" "" "" "" "" "" "" "" "424.9" "367.7" "377.2" "371.3" "356.2" "370.4" "337.9" "336.9" "397.2" "561.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6546315403352841289" "False" "High" "IsMasterProtein" "Q9Y2B0" "Protein canopy homolog 2 OS=Homo sapiens OX=9606 GN=CNPY2 PE=1 SV=1" "0.000" "False" "24.051" "26" "4" "11" "4" "182" "20.6" "4.92" "24.78" "4" "other biological processes" "ER/Golgi" "" "Pf11938" "10330" "ENSG00000257727" "CNPY2" "B2R7B9; Q9UHE9; Q9Y2B0" "" "" "0" "0" "1.006" "1.094" "0.997" "1.131" "1.040" "1.054" "1.081" "1.129" "0.756" "471.1" "474.1" "515.2" "469.5" "533.0" "490.2" "496.6" "509.5" "531.8" "356.2" "" "" "" "" "" "" "" "" "" "" "282.0" "246.4" "285.3" "220.4" "247.0" "250.9" "230.9" "228.7" "288.5" "356.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4462152622631022902" "False" "High" "IsMasterProtein" "Q92922" "SWI/SNF complex subunit SMARCC1 OS=Homo sapiens OX=9606 GN=SMARCC1 PE=1 SV=3" "0.000" "False" "24.050" "7" "8" "10" "4" "1105" "122.8" "5.76" "18.58" "8" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf04433, Pf16495, Pf16496, Pf16498" "6599" "ENSG00000173473" "SMARCC1" "hsa:6599; Q17RS0; Q6P172; Q8IWH2; Q92922" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "6" "0" "0.881" "1.619" "0.869" "0.445" "1.399" "1.269" "0.522" "0.842" "8.929" "26.8" "23.6" "43.4" "23.3" "11.9" "37.5" "34.0" "14.0" "22.6" "239.4" "" "" "" "" "" "" "" "" "" "" "16.0" "12.3" "24.0" "10.9" "5.5" "19.2" "15.8" "6.3" "12.2" "239.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1393255483118757770" "False" "High" "IsMasterProtein" "Q9H2U2" "Inorganic pyrophosphatase 2, mitochondrial OS=Homo sapiens OX=9606 GN=PPA2 PE=1 SV=2" "0.000" "False" "24.019" "20" "6" "28" "5" "334" "37.9" "7.39" "59.71" "6" "other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00719" "27068" "ENSG00000138777" "PPA2" "B4DLP7; F8WDN9; hsa:27068; I6L9B6; Q4W5E9; Q6PG51; Q8TBW0; Q96E55; Q9H0T0; Q9H2U2; Q9NX37; Q9P033; Q9ULX0" "" "Mitochondrial tRNA aminoacylation; Pyrophosphate hydrolysis" "2" "0" "1.158" "1.124" "1.287" "1.256" "1.249" "1.118" "1.178" "1.074" "0.621" "171.3" "198.4" "192.5" "220.6" "215.2" "213.9" "191.6" "201.8" "184.0" "106.4" "" "" "" "" "" "" "" "" "" "" "102.5" "103.1" "106.6" "103.6" "99.7" "109.5" "89.1" "90.6" "99.8" "106.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4807008432777767819" "False" "High" "IsMasterProtein" "Q9NTZ6" "RNA-binding protein 12 OS=Homo sapiens OX=9606 GN=RBM12 PE=1 SV=1" "0.000" "False" "24.013" "9" "7" "7" "7" "932" "97.3" "8.63" "19.06" "7" "other biological processes" "nucleus;other cell component" "" "Pf00076" "10137" "ENSG00000244462" "RBM12" "B3KRU2; E1P5R6; hsa:10137; O94865; Q8N3B1; Q9H196; Q9NTZ6" "" "" "0" "0" "1.219" "1.421" "1.464" "1.382" "1.329" "1.281" "0.875" "1.151" "5.312" "257.6" "314.1" "366.1" "377.2" "355.9" "342.2" "329.9" "225.4" "296.5" "1368.5" "" "" "" "" "" "" "" "" "" "" "154.2" "163.2" "202.7" "177.1" "165.0" "175.2" "153.4" "101.2" "160.9" "1368.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8263203131680576726" "False" "High" "IsMasterProtein" "Cont_P13717" "Nuclease OS=Serratia marcescens OX=615 GN=nucA PE=1 SV=2" "0.000" "True" "23.978" "18" "5" "22" "5" "266" "28.9" "7.42" "60.52" "5" "" "non-structural extracellular" "nucleic acid binding activity;other molecular function" "Pf01223" "66715254" "" "nucA" "A0A2V4G0H5; A0A5C7C9X8; A0A656VIL2; P13717" "" "" "0" "0" "1.110" "1.122" "1.113" "1.031" "1.063" "1.056" "1.141" "1.147" "0.582" "1719.2" "1908.8" "1929.2" "1914.1" "1772.2" "1826.7" "1816.3" "1961.8" "1971.2" "1000.5" "" "" "" "" "" "" "" "" "" "" "1028.8" "991.9" "1068.3" "898.6" "821.5" "935.1" "844.5" "880.7" "1069.5" "1000.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7544877575899964257" "False" "High" "IsMasterProtein" "Q96C57" "Protein CUSTOS OS=Homo sapiens OX=9606 GN=CUSTOS PE=1 SV=2" "0.000" "False" "23.860" "23" "5" "9" "5" "262" "28.2" "9.42" "23.97" "5" "cell-cell signaling;signal transduction;other biological processes" "nucleus" "" "" "64897" "ENSG00000157895" "CUSTOS" "Q53HF0; Q96C57; Q9H9Z7" "" "" "0" "0" "1.053" "0.884" "1.069" "1.067" "0.986" "1.017" "1.185" "0.921" "0.509" "249.0" "262.3" "220.2" "266.1" "265.7" "245.5" "253.2" "295.0" "229.4" "126.6" "" "" "" "" "" "" "" "" "" "" "149.0" "136.3" "121.9" "124.9" "123.2" "125.7" "117.7" "132.4" "124.4" "126.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3565723958770546681" "False" "High" "IsMasterProtein" "Q08378" "Golgin subfamily A member 3 OS=Homo sapiens OX=9606 GN=GOLGA3 PE=1 SV=2" "0.000" "False" "23.838" "6" "9" "12" "9" "1498" "167.3" "5.44" "24.43" "9" "" "other membranes;cytosol;ER/Golgi;nucleus" "" "" "2802" "ENSG00000090615" "GOLGA3" "A5PKX6; hsa:2802; O43241; Q08378; Q6P9C7; Q86XW3; Q8TDA9; Q8WZA3" "" "RND2 GTPase cycle" "1" "0" "1.287" "1.315" "1.146" "1.253" "1.098" "1.214" "1.148" "1.244" "1.435" "143.8" "185.1" "189.1" "164.8" "180.2" "157.9" "174.6" "165.1" "179.0" "206.4" "" "" "" "" "" "" "" "" "" "" "86.1" "96.2" "104.7" "77.4" "83.5" "80.8" "81.2" "74.1" "97.1" "206.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3363379489977265255" "False" "High" "IsMasterProtein" "P00441" "Superoxide dismutase [Cu-Zn] OS=Homo sapiens OX=9606 GN=SOD1 PE=1 SV=2" "0.000" "False" "23.831" "28" "4" "44" "4" "154" "15.9" "6.13" "121.31" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00080" "6647" "ENSG00000142168" "SOD1" "A6NHJ0; D3DSE4; P00441; Q16669; Q16711; Q16838; Q16839; Q16840; Q6NR85" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; AGE/RAGE pathway; Dopamine metabolism; Amyotrophic lateral sclerosis (ALS); Trans-sulfuration, one-carbon metabolism and related pathways; Copper homeostasis; Physico-chemical features and toxicity-associated pathways; One-carbon metabolism and related pathways; Oxidative stress response; Extracellular vesicles in the crosstalk of cardiac cells; Arsenic metabolism and reactive oxygen species generation; HDAC6 interactions in the central nervous system" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Platelet degranulation ; Detoxification of Reactive Oxygen Species" "17" "0" "1.057" "1.046" "1.078" "1.059" "1.046" "1.123" "1.178" "0.971" "0.591" "2564.9" "2711.8" "2682.3" "2765.0" "2716.9" "2683.1" "2880.0" "3022.0" "2490.4" "1515.1" "" "" "" "" "" "" "" "" "" "" "1534.9" "1409.2" "1485.4" "1298.1" "1259.3" "1373.5" "1339.1" "1356.7" "1351.2" "1515.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2537127350626285919" "False" "High" "IsMasterProtein" "P49959" "Double-strand break repair protein MRE11 OS=Homo sapiens OX=9606 GN=MRE11 PE=1 SV=3" "0.000" "False" "23.804" "15" "9" "12" "9" "708" "80.5" "5.90" "22.61" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00149, Pf04152" "4361" "ENSG00000020922" "MRE11" "B3KTC7; hsa:4361; O43475; P49959" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; Breast cancer pathway; Joubert syndrome; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Neurogenesis regulation in the olfactory epithelium; DNA damage response" "Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Cytosolic sensors of pathogen-associated DNA ; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks; IRF3-mediated induction of type I IFN" "31" "0" "0.957" "0.899" "0.893" "1.041" "0.956" "0.884" "0.897" "0.921" "1.206" "411.6" "393.7" "370.2" "367.5" "428.3" "393.4" "363.7" "369.2" "378.9" "496.2" "" "" "" "" "" "" "" "" "" "" "246.3" "204.6" "205.0" "172.5" "198.5" "201.4" "169.1" "165.7" "205.5" "496.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3690320084066520669" "False" "High" "IsMasterProtein" "Cont_P04259" "Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5" "0.000" "True" "23.789" "10" "8" "14" "2" "564" "60.0" "8.00" "36.23" "8" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3854" "ENSG00000185479" "KRT6B" "hsa:3854; P04259; P48669" "" "Formation of the cornified envelope" "2" "0" "0.435" "1.465" "0.566" "0.416" "0.671" "0.525" "1.010" "0.887" "2.423" "88.8" "38.6" "130.0" "50.2" "36.9" "59.5" "46.6" "89.6" "78.8" "215.1" "" "" "" "" "" "" "" "" "" "" "53.1" "20.1" "72.0" "23.6" "17.1" "30.5" "21.7" "40.2" "42.7" "215.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4669002677123591675" "False" "High" "IsMasterProtein" "P06493" "Cyclin-dependent kinase 1 OS=Homo sapiens OX=9606 GN=CDK1 PE=1 SV=3" "0.000" "False" "23.773" "16" "5" "15" "4" "297" "34.1" "8.40" "40.12" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "983" "ENSG00000170312" "CDK1" "A8K7C4; C9J497; hsa:983; O60764; P06493" "miRNA regulation of DNA damage response; Cell cycle; Microtubule cytoskeleton regulation; Spinal cord injury; Retinoblastoma gene in cancer; ATM signaling pathway; PPAR-alpha pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; G1 to S cell cycle control; Cohesin complex - Cornelia de Lange syndrome; Urotensin-II-mediated signaling pathway; DNA damage response" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Golgi Cisternae Pericentriolar Stack Reorganization; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; PKR-mediated signaling; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of TP53 Degradation; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of the APC/C; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Transcriptional regulation by RUNX2; Ovarian tumor domain proteases; MASTL Facilitates Mitotic Progression; E2F-enabled inhibition of pre-replication complex formation; MAPK3 (ERK1) activation; Condensation of Prophase Chromosomes; G1/S-Specific Transcription; Initiation of Nuclear Envelope (NE) Reformation; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Depolymerization of the Nuclear Lamina; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes; Phosphorylation of Emi1" "50" "0" "1.012" "1.019" "1.091" "1.050" "1.108" "1.322" "1.321" "1.334" "1.491" "287.7" "291.1" "293.3" "314.0" "302.0" "318.7" "380.5" "380.1" "383.9" "428.9" "" "" "" "" "" "" "" "" "" "" "172.2" "151.3" "162.4" "147.4" "140.0" "163.1" "176.9" "170.7" "208.3" "428.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6706450895826488783" "False" "High" "IsMasterProtein" "Q9H9Q2" "COP9 signalosome complex subunit 7b OS=Homo sapiens OX=9606 GN=COPS7B PE=1 SV=1" "0.000" "False" "23.771" "22" "5" "8" "5" "264" "29.6" "6.15" "18.35" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf18392" "64708" "ENSG00000144524" "COPS7B" "hsa:64708; Q53S22; Q5BJG3; Q9H7V6; Q9H9Q2" "Ciliary landscape" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER" "5" "0" "1.133" "1.127" "1.325" "1.073" "1.036" "1.239" "1.178" "1.123" "0.698" "590.1" "668.9" "665.4" "782.0" "633.5" "611.7" "731.0" "695.3" "662.7" "411.9" "" "" "" "" "" "" "" "" "" "" "353.2" "347.6" "368.5" "367.1" "293.6" "313.1" "339.9" "312.1" "359.6" "411.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3533447776593040930" "False" "High" "IsMasterProtein" "P26599" "Polypyrimidine tract-binding protein 1 OS=Homo sapiens OX=9606 GN=PTBP1 PE=1 SV=2" "0.000" "False" "23.758" "11" "6" "13" "4" "557" "59.6" "9.16" "39.65" "6" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "5725" "ENSG00000011304" "PTBP1" "hsa:5725; P26599; Q9BUQ0" "mir-124 predicted interactions with cell cycle and differentiation ; mRNA processing" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "5" "2" "0.964" "1.004" "1.175" "1.276" "0.963" "1.142" "0.539" "0.951" "7.670" "295.4" "284.9" "296.6" "347.0" "377.0" "284.3" "337.2" "159.2" "280.9" "2265.7" "" "" "" "" "" "" "" "" "" "" "176.8" "148.0" "164.3" "162.9" "174.7" "145.6" "156.8" "71.5" "152.4" "2265.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6184092773991491015" "False" "High" "IsMasterProtein" "P39748" "Flap endonuclease 1 OS=Homo sapiens OX=9606 GN=FEN1 PE=1 SV=1" "0.000" "False" "23.746" "15" "6" "13" "6" "380" "42.6" "8.62" "43.04" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00752, Pf00867" "2237" "ENSG00000168496" "FEN1" "hsa:2237; P39748" "Base excision repair; DNA repair pathways, full network" "HDR through MMEJ (alt-NHEJ); Early Phase of HIV Life Cycle; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Removal of the Flap Intermediate; Removal of the Flap Intermediate from the C-strand" "8" "0" "0.941" "1.010" "1.126" "1.063" "1.024" "1.042" "0.276" "1.041" "8.733" "357.2" "336.2" "360.9" "402.1" "379.7" "365.8" "372.4" "98.5" "372.0" "3119.6" "" "" "" "" "" "" "" "" "" "" "213.8" "174.7" "199.9" "188.8" "176.0" "187.3" "173.2" "44.2" "201.8" "3119.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4793391525152750587" "False" "High" "IsMasterProtein" "P61020" "Ras-related protein Rab-5B OS=Homo sapiens OX=9606 GN=RAB5B PE=1 SV=1" "0.000" "False" "23.742" "24" "4" "12" "1" "215" "23.7" "8.13" "36.69" "4" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5869" "ENSG00000111540" "RAB5B" "A8K982; B4DKD7; hsa:5869; P35239; P35277; P61020; Q6PIK9; Q86TH0; Q8IXL2" "Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Vasopressin-regulated water reabsorption" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; TBC/RABGAPs" "9" "0" "1.446" "1.389" "1.539" "0.948" "1.346" "1.458" "1.402" "1.161" "0.685" "16.0" "23.1" "22.2" "24.6" "15.2" "21.5" "23.3" "22.4" "18.5" "10.9" "" "" "" "" "" "" "" "" "" "" "9.6" "12.0" "12.3" "11.5" "7.0" "11.0" "10.8" "10.1" "10.1" "10.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2706346813500612186" "False" "High" "IsMasterProtein" "Q9C0C9" "(E3-independent) E2 ubiquitin-conjugating enzyme OS=Homo sapiens OX=9606 GN=UBE2O PE=1 SV=3" "0.000" "False" "23.707" "6" "8" "11" "8" "1292" "141.2" "5.12" "23.15" "8" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "63893" "ENSG00000175931" "UBE2O" "A6NDU5; hsa:63893; Q69YP4; Q6PIZ2; Q86UA4; Q8N425; Q8TBN1; Q9BSW1; Q9C0C9; Q9H6E6; Q9H7E4; Q9H9B2" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.992" "1.177" "1.251" "1.197" "1.006" "1.124" "0.835" "1.086" "4.863" "114.4" "113.5" "134.6" "143.1" "136.9" "115.1" "128.6" "95.6" "124.3" "556.3" "" "" "" "" "" "" "" "" "" "" "68.5" "59.0" "74.6" "67.2" "63.5" "58.9" "59.8" "42.9" "67.4" "556.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2043411241930693309" "False" "High" "IsMasterProtein" "Q96JM3" "Chromosome alignment-maintaining phosphoprotein 1 OS=Homo sapiens OX=9606 GN=CHAMP1 PE=1 SV=2" "0.000" "False" "23.700" "8" "5" "6" "5" "812" "89.0" "8.44" "18.56" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "" "283489" "ENSG00000198824" "CHAMP1" "B3KU06; hsa:283489; Q6P181; Q8NC88; Q96JM3; Q9BST0" "" "" "0" "0" "1.083" "1.000" "1.186" "0.894" "0.875" "0.942" "0.939" "1.009" "2.283" "158.2" "171.3" "158.2" "187.6" "141.5" "138.5" "149.0" "148.6" "159.6" "361.2" "" "" "" "" "" "" "" "" "" "" "94.7" "89.0" "87.6" "88.1" "65.6" "70.9" "69.3" "66.7" "86.6" "361.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93919318191628628" "False" "High" "IsMasterProtein" "Q92499" "ATP-dependent RNA helicase DDX1 OS=Homo sapiens OX=9606 GN=DDX1 PE=1 SV=2" "0.000" "False" "23.653" "10" "7" "11" "7" "740" "82.4" "7.23" "28.03" "7" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00622" "1653" "ENSG00000079785" "DDX1" "B4DME8; B4DPN6; hsa:1653; Q92499" "DDX1 as a regulatory component of the Drosha microprocessor; mRNA processing" "tRNA processing in the nucleus" "3" "0" "0.943" "1.060" "1.095" "1.149" "1.108" "0.983" "0.696" "1.047" "4.448" "371.0" "350.0" "393.2" "406.3" "426.3" "410.9" "364.8" "258.3" "388.3" "1649.9" "" "" "" "" "" "" "" "" "" "" "222.0" "181.9" "217.7" "190.7" "197.6" "210.3" "169.6" "115.9" "210.7" "1649.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "59184659773015562" "False" "High" "IsMasterProtein" "Q969H8" "Myeloid-derived growth factor OS=Homo sapiens OX=9606 GN=MYDGF PE=1 SV=1" "0.000" "False" "23.646" "31" "6" "19" "6" "173" "18.8" "6.68" "48.70" "6" "developmental processes;other biological processes" "non-structural extracellular;ER/Golgi" "" "Pf10572" "56005" "ENSG00000074842" "MYDGF" "D6W628; hsa:56005; O75256; O75272; Q969H8; Q9BTK7; Q9NP69" "" "XBP1(S) activates chaperone genes" "1" "0" "0.988" "1.067" "0.965" "0.954" "0.968" "0.894" "1.046" "0.945" "0.505" "785.5" "775.9" "837.9" "758.3" "749.2" "760.3" "702.6" "821.8" "742.3" "396.4" "" "" "" "" "" "" "" "" "" "" "470.1" "403.2" "464.0" "356.0" "347.3" "389.2" "326.7" "368.9" "402.7" "396.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9193943049168300683" "False" "High" "IsMasterProtein" "Q02818" "Nucleobindin-1 OS=Homo sapiens OX=9606 GN=NUCB1 PE=1 SV=4" "0.000" "False" "23.631" "17" "8" "9" "8" "461" "53.8" "5.25" "26.41" "8" "signal transduction" "ER/Golgi" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "" "4924" "ENSG00000104805" "NUCB1" "B2RD64; hsa:4924; Q02818; Q15838; Q7Z4J7; Q9BUR1" "" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "2" "0" "0.976" "0.888" "1.012" "1.062" "0.912" "1.101" "1.114" "1.017" "0.544" "605.1" "590.7" "537.2" "612.4" "642.8" "551.6" "666.4" "674.1" "615.1" "329.3" "" "" "" "" "" "" "" "" "" "" "362.1" "306.9" "297.5" "287.5" "298.0" "282.4" "309.8" "302.6" "333.7" "329.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7210504404319708374" "False" "High" "IsMasterProtein" "P33240" "Cleavage stimulation factor subunit 2 OS=Homo sapiens OX=9606 GN=CSTF2 PE=1 SV=1" "0.000" "False" "23.630" "14" "8" "15" "4" "577" "60.9" "6.83" "31.32" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf14304, Pf14327" "1478" "ENSG00000101811" "CSTF2" "hsa:1478; P33240; Q5H951; Q6LA74; Q8N502" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; tRNA processing in the nucleus; Processing of Intronless Pre-mRNAs" "6" "4" "1.088" "1.020" "1.196" "1.251" "0.975" "1.204" "1.127" "1.053" "0.840" "345.9" "376.4" "352.9" "413.7" "432.7" "337.3" "416.3" "389.9" "364.1" "290.4" "" "" "" "" "" "" "" "" "" "" "207.0" "195.6" "195.4" "194.2" "200.6" "172.7" "193.6" "175.1" "197.5" "290.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2832146552711634492" "False" "High" "IsMasterProtein" "Q02218" "2-oxoglutarate dehydrogenase complex component E1 OS=Homo sapiens OX=9606 GN=OGDH PE=1 SV=3" "0.000" "False" "23.625" "6" "7" "13" "7" "1023" "115.9" "6.86" "33.73" "7" "protein metabolism;other metabolic processes;developmental processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00676, Pf02779, Pf16078, Pf16870" "4967" "ENSG00000105953" "OGDH" "B4E2U9; D3DVL0; E9PBM1; hsa:4967; Q02218; Q96DD3; Q9UDX0" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Thiamine metabolic pathways; 7q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)" "Lysine catabolism; Glyoxylate metabolism and glycine degradation; Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "9" "0" "0.975" "0.978" "1.052" "1.072" "1.078" "0.933" "0.756" "0.993" "3.521" "429.6" "419.1" "420.3" "452.1" "460.4" "463.2" "400.9" "324.6" "426.5" "1512.6" "" "" "" "" "" "" "" "" "" "" "257.1" "217.8" "232.8" "212.3" "213.4" "237.1" "186.4" "145.7" "231.4" "1512.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7722253779426460975" "False" "High" "IsMasterProtein" "O00571" "ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=3" "0.000" "False" "23.615" "11" "7" "16" "7" "662" "73.2" "7.18" "32.33" "7" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1654" "ENSG00000215301" "DDX3X" "A8K538; B4E3E8; hsa:1654; O00571; O15536" "Novel intracellular components of RIG-I-like receptor pathway; Hepatitis B infection" "Neutrophil degranulation" "3" "0" "1.105" "1.213" "1.227" "1.166" "1.156" "1.144" "0.857" "1.284" "5.451" "285.4" "315.5" "346.3" "350.1" "332.9" "329.9" "326.5" "244.5" "366.5" "1555.8" "" "" "" "" "" "" "" "" "" "" "170.8" "164.0" "191.8" "164.4" "154.3" "168.9" "151.8" "109.8" "198.8" "1555.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4101448346661809879" "False" "High" "IsMasterProtein" "Q15819" "Ubiquitin-conjugating enzyme E2 variant 2 OS=Homo sapiens OX=9606 GN=UBE2V2 PE=1 SV=4" "0.000" "False" "23.538" "51" "7" "40" "3" "145" "16.4" "8.09" "86.78" "7" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf00179" "7336" "ENSG00000169139" "UBE2V2" "hsa:7336; Q15819" "" "Antigen processing: Ubiquitination & Proteasome degradation; E3 ubiquitin ligases ubiquitinate target proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Formation of Incision Complex in GG-NER" "7" "0" "1.106" "1.018" "1.233" "1.120" "1.066" "1.089" "1.132" "1.060" "0.924" "350.7" "387.9" "357.0" "432.3" "392.8" "373.9" "381.9" "397.0" "371.7" "324.1" "" "" "" "" "" "" "" "" "" "" "209.9" "201.6" "197.7" "203.0" "182.1" "191.4" "177.6" "178.2" "201.6" "324.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5521793610303513807" "False" "High" "IsMasterProtein" "P52789" "Hexokinase-2 OS=Homo sapiens OX=9606 GN=HK2 PE=1 SV=2" "0.000" "False" "23.497" "8" "8" "12" "6" "917" "102.3" "6.05" "26.73" "8" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00349, Pf03727" "3099" "ENSG00000159399" "HK2" "D6W5J2; hsa:3099; P52789; Q8WU87; Q9UN82" "Clear cell renal cell carcinoma pathways; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Macrophage-stimulating protein (MSP) signaling network map; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts" "Glycolysis" "7" "0" "0.992" "1.072" "1.134" "1.153" "1.110" "1.108" "0.435" "1.069" "8.245" "173.0" "171.7" "185.5" "196.3" "199.5" "192.0" "191.7" "75.2" "184.9" "1426.6" "" "" "" "" "" "" "" "" "" "" "103.5" "89.2" "102.7" "92.2" "92.5" "98.3" "89.1" "33.8" "100.3" "1426.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4517606527837170781" "False" "High" "IsMasterProtein" "Q9Y5P6" "Mannose-1-phosphate guanyltransferase beta OS=Homo sapiens OX=9606 GN=GMPPB PE=1 SV=2" "0.000" "False" "23.445" "20" "5" "7" "5" "360" "39.8" "6.61" "16.65" "5" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00132, Pf00483" "29925" "ENSG00000173540" "GMPPB" "A8K6N5; hsa:29925; Q9H7U3; Q9Y5P6" "N-glycan biosynthesis" "Synthesis of GDP-mannose" "2" "0" "1.135" "0.952" "1.106" "1.108" "1.258" "1.081" "1.079" "1.046" "0.707" "225.5" "256.0" "214.6" "249.5" "249.9" "283.7" "243.8" "243.4" "235.9" "159.5" "" "" "" "" "" "" "" "" "" "" "135.0" "133.0" "118.9" "117.1" "115.8" "145.2" "113.3" "109.3" "128.0" "159.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8172346971524846949" "False" "High" "IsMasterProtein" "Q13126" "S-methyl-5'-thioadenosine phosphorylase OS=Homo sapiens OX=9606 GN=MTAP PE=1 SV=2" "0.000" "False" "23.348" "22" "5" "10" "5" "283" "31.2" "7.18" "25.05" "5" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf01048" "4507" "ENSG00000099810" "MTAP" "hsa:4507; I2G7M5; I2G7M6; I2G7M7; I2G7M8; I2G7M9; I2G7N0; Q13126; Q5T3P3; Q9H010" "Methionine de novo and salvage pathway" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Methionine salvage pathway" "3" "0" "0.967" "0.977" "1.017" "1.005" "0.839" "1.096" "0.990" "1.045" "0.664" "283.4" "274.1" "276.8" "288.3" "284.8" "237.9" "310.7" "280.5" "296.2" "188.3" "" "" "" "" "" "" "" "" "" "" "169.6" "142.5" "153.3" "135.3" "132.0" "121.8" "144.5" "125.9" "160.7" "188.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7527974897574347786" "False" "High" "IsMasterProtein" "Q16778" "Histone H2B type 2-E OS=Homo sapiens OX=9606 GN=H2BC21 PE=1 SV=3" "0.000" "False" "23.284" "45" "6" "40" "6" "126" "13.9" "10.32" "98.31" "6" "cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "8349" "ENSG00000184678" "H2BC21" "A3KMC7; A8K110; hsa:8349; Q16778; Q4KMY1; Q5QNX0; Q9UE88" "" "Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression; Amyloid fiber formation; Meiotic synapsis; HCMV Late Events; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Early Events; Transcriptional regulation by small RNAs; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Replacement of protamines by nucleosomes in the male pronucleus" "44" "0" "0.853" "1.065" "0.862" "0.891" "0.927" "0.793" "0.786" "0.903" "1.028" "1671.0" "1424.8" "1779.3" "1440.8" "1489.0" "1548.2" "1325.4" "1313.8" "1508.7" "1718.5" "" "" "" "" "" "" "" "" "" "" "1000.0" "740.4" "985.3" "676.4" "690.2" "792.6" "616.3" "589.8" "818.5" "1718.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6789229082663828317" "False" "High" "IsMasterProtein" "Q6ZUJ8" "Phosphoinositide 3-kinase adapter protein 1 OS=Homo sapiens OX=9606 GN=PIK3AP1 PE=1 SV=2" "0.000" "False" "23.233" "7" "5" "8" "5" "805" "90.3" "5.40" "12.00" "5" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "signal transduction activity or receptor binding;other molecular function" "Pf14545, Pf18567" "118788" "ENSG00000155629" "PIK3AP1" "hsa:118788; Q5TB56; Q5VXJ9; Q6ZUJ8; Q8N6J6; Q8NAC8" "B cell receptor signaling pathway; PI3K-Akt signaling pathway" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer" "6" "0" "0.988" "1.597" "1.354" "1.212" "1.099" "1.719" "1.489" "1.663" "4.170" "22.0" "21.7" "35.2" "29.8" "26.7" "24.2" "37.8" "32.8" "36.6" "91.8" "" "" "" "" "" "" "" "" "" "" "13.2" "11.3" "19.5" "14.0" "12.4" "12.4" "17.6" "14.7" "19.9" "91.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1858767456070720034" "False" "High" "IsMasterProtein" "P55735" "Protein SEC13 homolog OS=Homo sapiens OX=9606 GN=SEC13 PE=1 SV=3" "0.000" "False" "23.207" "21" "5" "6" "5" "322" "35.5" "5.48" "19.46" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "6396" "ENSG00000157020" "SEC13" "A8MV37; B4DXJ1; hsa:6396; P55735; Q5BJF0; Q9BRM6; Q9BUG7" "Sterol regulatory element-binding proteins (SREBP) signaling" "COPII-mediated vesicle transport; MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; snRNP Assembly; Regulation of HSF1-mediated heat shock response; Separation of Sister Chromatids; HCMV Late Events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Amino acids regulate mTORC1; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "40" "0" "1.409" "1.392" "1.216" "1.251" "1.461" "1.147" "1.074" "1.272" "3.123" "108.8" "153.4" "151.5" "132.4" "136.2" "159.0" "124.8" "116.9" "138.4" "339.9" "" "" "" "" "" "" "" "" "" "" "65.1" "79.7" "83.9" "62.1" "63.1" "81.4" "58.0" "52.5" "75.1" "339.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "677526654360538548" "False" "High" "IsMasterProtein" "Q99733" "Nucleosome assembly protein 1-like 4 OS=Homo sapiens OX=9606 GN=NAP1L4 PE=1 SV=1" "0.000" "False" "23.195" "15" "6" "19" "5" "375" "42.8" "4.69" "46.17" "6" "cell organization and biogenesis" "nucleus;other cell component" "other molecular function" "Pf00956" "4676" "ENSG00000205531; ENSG00000273562" "NAP1L4" "B2R6J4; F5HFY4; hsa:4676; Q99733" "" "" "0" "1" "1.013" "1.146" "1.160" "1.180" "1.151" "1.011" "0.781" "1.155" "2.244" "326.5" "330.7" "374.1" "378.8" "385.2" "375.9" "330.1" "255.0" "377.1" "732.7" "" "" "" "" "" "" "" "" "" "" "195.4" "171.9" "207.2" "177.8" "178.6" "192.4" "153.5" "114.5" "204.6" "732.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2616426161905977358" "False" "High" "IsMasterProtein" "Q9UG63" "ATP-binding cassette sub-family F member 2 OS=Homo sapiens OX=9606 GN=ABCF2 PE=1 SV=2" "0.000" "False" "23.135" "9" "5" "14" "5" "623" "71.2" "7.37" "26.48" "5" "" "" "other molecular function" "Pf00005, Pf12848" "10061; 114483834" "ENSG00000033050" "ABCF2" "hsa:10061; hsa:114483834; O60864; Q75MJ0; Q75MJ1; Q96TE8; Q9UG63" "VEGFA-VEGFR2 signaling" "NFE2L2 regulating MDR associated enzymes" "2" "0" "1.019" "0.864" "1.018" "0.910" "0.984" "1.068" "1.013" "0.983" "1.113" "327.7" "334.0" "283.1" "333.7" "298.1" "322.3" "349.9" "332.1" "322.1" "364.8" "" "" "" "" "" "" "" "" "" "" "196.1" "173.6" "156.8" "156.7" "138.2" "165.0" "162.7" "149.1" "174.7" "364.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1166927996766443346" "False" "High" "IsMasterProtein" "P28482" "Mitogen-activated protein kinase 1 OS=Homo sapiens OX=9606 GN=MAPK1 PE=1 SV=3" "0.000" "False" "23.132" "19" "8" "20" "8" "360" "41.4" "6.98" "50.14" "8" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "5594" "ENSG00000100030" "MAPK1" "A8CZ64; hsa:5594; P28482" "IL-5 signaling pathway; Osteopontin signaling; Physiological and pathological hypertrophy of the heart; Angiogenesis; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; Heart development; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Endothelin pathways; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; PDGF pathway; Aryl hydrocarbon receptor pathway; S1P receptor signal transduction; Ebstein-Barr virus LMP1 signaling; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; TCA cycle nutrient use and invasiveness of ovarian cancer; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; IL6 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; ERK pathway in Huntington's disease; Toll-like receptor signaling related to MyD88; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; Prion disease pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Neovascularization processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Bile acids synthesis and enterohepatic circulation ; LTF danger signal response pathway; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Regulatory circuits of the STAT3 signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; Kisspeptin/kisspeptin receptor system in the ovary; MAP3K1 role in promoting and blocking gonadal determination; CAMKK2 pathway; Disruption of postsynaptic signaling by CNV; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; RAS and bradykinin pathways in COVID-19; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Sphingolipid metabolism in senescence; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; 2q11.2 copy number variation syndrome; 2q13 copy number variation syndrome; Hippocampal synaptogenesis and neurogenesis; Comprehensive IL-17A signaling; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; Female steroid hormones in cardiomyocyte energy metabolism; Cardiomyocyte signaling pathways converging on titin; 8p23.1 copy number variation syndrome; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; Osteoarthritic chondrocyte hypertrophy; NPHP1 deletion syndrome; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Vitamin A and carotenoid metabolism; Toll-like receptor signaling pathway" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of actin dynamics for phagocytic cup formation; Recycling pathway of L1; FCERI mediated MAPK activation; FCGR3A-mediated phagocytosis; NPAS4 regulates expression of target genes; RHO GTPases Activate WASPs and WAVEs; Regulation of HSF1-mediated heat shock response; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Signaling by NODAL; Interferon gamma signaling; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Growth hormone receptor signaling; Regulation of the apoptosome activity; Signal transduction by L1; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RUNX2 regulates osteoblast differentiation; RSK activation; Estrogen-stimulated signaling through PRKCZ; Spry regulation of FGF signaling; Suppression of apoptosis; MAPK1 (ERK2) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; IFNG signaling activates MAPKs; Golgi Cisternae Pericentriolar Stack Reorganization; Signaling by Activin; Activation of the AP-1 family of transcription factors; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Signal attenuation; Gastrin-CREB signalling pathway via PKC and MAPK; ESR-mediated signaling; Negative feedback regulation of MAPK pathway; Advanced glycosylation endproduct receptor signaling; RHO GTPases Activate NADPH Oxidases; Nuclear events stimulated by ALK signaling in cancer; ERKs are inactivated; Signaling by MAP2K mutants; phospho-PLA2 pathway; Signaling by MAPK mutants" "208" "0" "0.950" "0.952" "1.043" "0.988" "0.966" "0.919" "0.998" "0.953" "0.744" "1269.0" "1205.5" "1207.8" "1324.0" "1253.5" "1225.8" "1166.8" "1267.0" "1209.9" "943.9" "" "" "" "" "" "" "" "" "" "" "759.4" "626.4" "668.9" "621.6" "581.0" "627.5" "542.5" "568.8" "656.4" "943.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4181332469245940194" "False" "High" "IsMasterProtein" "Q9UMR2" "ATP-dependent RNA helicase DDX19B OS=Homo sapiens OX=9606 GN=DDX19B PE=1 SV=1" "0.000" "False" "23.121" "17" "7" "10" "7" "479" "53.9" "6.30" "25.11" "7" "other metabolic processes;transport" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "11269" "ENSG00000157349" "DDX19B" "B3KNE9; B4DXS6; E7EMK4; hsa:11269; Q6FIB7; Q6IAE0; Q96KE7; Q9H0U0; Q9UMR2" "" "" "0" "0" "1.062" "1.122" "1.101" "1.103" "1.102" "1.074" "0.879" "1.157" "3.365" "155.1" "164.8" "174.1" "170.8" "171.0" "170.9" "166.6" "136.4" "179.4" "521.9" "" "" "" "" "" "" "" "" "" "" "92.8" "85.6" "96.4" "80.2" "79.3" "87.5" "77.5" "61.2" "97.3" "521.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7097595206598813277" "False" "High" "IsMasterProtein" "P09012" "U1 small nuclear ribonucleoprotein A OS=Homo sapiens OX=9606 GN=SNRPA PE=1 SV=3" "0.000" "False" "23.068" "17" "6" "31" "4" "282" "31.3" "9.83" "70.06" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "6626" "ENSG00000077312" "SNRPA" "hsa:6626; P09012" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.033" "0.930" "0.977" "0.912" "0.999" "0.945" "0.989" "0.991" "0.560" "1550.6" "1602.2" "1442.0" "1514.7" "1413.5" "1549.6" "1464.9" "1533.5" "1536.0" "868.8" "" "" "" "" "" "" "" "" "" "" "927.9" "832.6" "798.5" "711.1" "655.2" "793.3" "681.2" "688.4" "833.4" "868.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5836561258245124912" "False" "High" "IsMasterProtein" "Q6P6C2" "RNA demethylase ALKBH5 OS=Homo sapiens OX=9606 GN=ALKBH5 PE=1 SV=2" "0.000" "False" "23.041" "18" "7" "13" "7" "394" "44.2" "9.09" "31.23" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf13532" "54890" "ENSG00000091542" "ALKBH5" "B4DVJ4; D3DXC6; hsa:54890; Q6P6C2; Q9NXD6" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Reversal of alkylation damage by DNA dioxygenases" "2" "0" "0.902" "0.812" "0.912" "0.928" "0.941" "0.881" "0.872" "0.812" "0.708" "243.3" "219.5" "197.5" "221.9" "225.8" "228.9" "214.4" "212.1" "197.5" "172.2" "" "" "" "" "" "" "" "" "" "" "145.6" "114.1" "109.4" "104.2" "104.6" "117.2" "99.7" "95.2" "107.1" "172.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3348063048302493190" "False" "High" "IsMasterProtein" "P50851" "Lipopolysaccharide-responsive and beige-like anchor protein OS=Homo sapiens OX=9606 GN=LRBA PE=1 SV=4" "0.000" "False" "23.016" "3" "6" "6" "6" "2863" "318.9" "5.60" "15.55" "6" "cell organization and biogenesis;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf02138, Pf06469, Pf13385, Pf14844, Pf15787, Pf20425, Pf20426" "987" "ENSG00000198589" "LRBA" "hsa:987; P50851; Q4W5J4; Q4W5L6; Q8NFQ0; Q9H2U3; Q9H2U4" "" "" "0" "0" "1.039" "1.153" "1.097" "0.944" "1.131" "1.040" "1.125" "1.110" "2.764" "94.6" "98.3" "109.1" "103.8" "89.3" "106.9" "98.3" "106.4" "105.0" "261.4" "" "" "" "" "" "" "" "" "" "" "56.6" "51.1" "60.4" "48.7" "41.4" "54.7" "45.7" "47.8" "57.0" "261.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5697914900789617779" "False" "High" "IsMasterProtein" "Q7RTV0" "PHD finger-like domain-containing protein 5A OS=Homo sapiens OX=9606 GN=PHF5A PE=1 SV=1" "0.000" "False" "23.012" "47" "5" "15" "5" "110" "12.4" "8.41" "40.93" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03660" "84844" "ENSG00000100410" "PHF5A" "hsa:84844; Q7RTV0; Q9UH06" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.072" "1.128" "0.973" "1.013" "1.029" "0.857" "0.991" "0.990" "0.295" "684.6" "733.9" "772.3" "666.1" "693.2" "704.1" "586.4" "678.5" "677.5" "202.0" "" "" "" "" "" "" "" "" "" "" "409.7" "381.4" "427.7" "312.7" "321.3" "360.4" "272.7" "304.6" "367.6" "202.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2309568012740462624" "False" "High" "IsMasterProtein" "Q02750" "Dual specificity mitogen-activated protein kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP2K1 PE=1 SV=2" "0.000" "False" "23.007" "18" "7" "21" "3" "393" "43.4" "6.62" "60.25" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "5604" "ENSG00000169032" "MAP2K1" "hsa:5604; Q02750" "IL-5 signaling pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; Endothelin pathways; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Aryl hydrocarbon receptor pathway; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; IL6 signaling pathway; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "Signaling by BRAF and RAF1 fusions; Uptake and function of anthrax toxins; Signal transduction by L1; RAF activation; MAP3K8 (TPL2)-dependent MAPK1/3 activation; MAPK3 (ERK1) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Negative feedback regulation of MAPK pathway; Signaling by MAP2K mutants" "102" "0" "0.976" "0.911" "0.956" "0.986" "1.010" "0.967" "1.043" "1.012" "0.925" "764.1" "745.7" "695.8" "730.5" "753.4" "771.9" "738.8" "797.2" "773.5" "706.9" "" "" "" "" "" "" "" "" "" "" "457.3" "387.5" "385.3" "342.9" "349.2" "395.1" "343.5" "357.9" "419.7" "706.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1708640290626267049" "False" "High" "IsMasterProtein" "P37108" "Signal recognition particle 14 kDa protein OS=Homo sapiens OX=9606 GN=SRP14 PE=1 SV=2" "0.000" "False" "22.989" "30" "5" "26" "5" "136" "14.6" "10.04" "74.53" "5" "other biological processes" "non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02290" "6727" "ENSG00000140319" "SRP14" "B5BUF5; hsa:6727; P37108; Q6B0K5; Q96Q14" "" "Neutrophil degranulation; SRP-dependent cotranslational protein targeting to membrane" "2" "0" "1.050" "0.994" "0.952" "1.019" "0.936" "0.986" "0.974" "0.939" "0.633" "3457.8" "3630.4" "3435.8" "3293.0" "3524.6" "3236.3" "3409.9" "3367.4" "3247.7" "2189.7" "" "" "" "" "" "" "" "" "" "" "2069.3" "1886.6" "1902.7" "1546.0" "1633.7" "1656.7" "1585.5" "1511.7" "1762.0" "2189.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3259776130493618651" "False" "High" "IsMasterProtein" "Q6PI48" "Aspartate--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=DARS2 PE=1 SV=1" "0.000" "False" "22.982" "11" "8" "12" "8" "645" "73.5" "8.02" "32.44" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336, Pf02938" "55157" "ENSG00000117593" "DARS2" "hsa:55157; Q6PI48" "" "Mitochondrial tRNA aminoacylation" "1" "0" "0.960" "1.100" "1.175" "1.115" "1.168" "1.075" "1.123" "1.045" "0.832" "332.4" "319.0" "365.7" "390.7" "370.7" "388.2" "357.3" "373.3" "347.4" "276.7" "" "" "" "" "" "" "" "" "" "" "198.9" "165.8" "202.5" "183.4" "171.8" "198.7" "166.1" "167.6" "188.5" "276.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4306142825200876867" "False" "High" "IsMasterProtein" "P11766" "Alcohol dehydrogenase class-3 OS=Homo sapiens OX=9606 GN=ADH5 PE=1 SV=4" "0.000" "False" "22.903" "18" "7" "31" "7" "374" "39.7" "7.49" "77.54" "7" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00107, Pf08240" "128" "ENSG00000197894" "ADH5" "hsa:128; P11766; Q6FHR2" "Folate-alcohol and cancer pathway hypotheses; Amino acid metabolism" "Ethanol oxidation" "3" "0" "1.025" "0.961" "1.001" "0.931" "1.039" "0.947" "1.036" "0.981" "0.578" "2696.5" "2763.7" "2590.1" "2699.7" "2510.4" "2802.0" "2553.9" "2794.1" "2645.3" "1559.5" "" "" "" "" "" "" "" "" "" "" "1613.7" "1436.2" "1434.3" "1267.5" "1163.6" "1434.4" "1187.5" "1254.4" "1435.2" "1559.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3174171264893505362" "False" "High" "IsMasterProtein" "Q9H2J4" "Phosducin-like protein 3 OS=Homo sapiens OX=9606 GN=PDCL3 PE=1 SV=1" "0.000" "False" "22.850" "24" "5" "14" "5" "239" "27.6" "4.84" "42.24" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02114" "79031" "ENSG00000115539" "PDCL3" "B2RA00; hsa:79031; Q53S68; Q9H2J4" "" "" "0" "0" "1.052" "1.033" "0.985" "0.973" "0.976" "1.022" "0.929" "1.011" "0.809" "910.6" "958.4" "941.0" "897.2" "886.0" "888.4" "930.4" "845.6" "920.4" "736.6" "" "" "" "" "" "" "" "" "" "" "545.0" "498.1" "521.1" "421.2" "410.7" "454.8" "432.6" "379.6" "499.4" "736.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1136415192925944721" "False" "High" "IsMasterProtein" "Q04864" "Proto-oncogene c-Rel OS=Homo sapiens OX=9606 GN=REL PE=1 SV=1" "0.000" "False" "22.835" "12" "6" "7" "6" "619" "68.5" "5.86" "22.02" "6" "stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "5966" "ENSG00000162924" "REL" "hsa:5966; Q04864; Q17RU2; Q2PNZ7; Q6LDY0" "IL-1 signaling pathway; Leptin signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Photodynamic therapy-induced NF-kB survival signaling; Toll-like receptor signaling related to MyD88; Fibrin complement receptor 3 signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; miRNA role in immune response in sepsis; Canonical NF-kB pathway; Head and neck squamous cell carcinoma; IL-18 signaling pathway; 16p11.2 proximal deletion syndrome; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; Interferon type I signaling pathways; T-cell receptor signaling pathway" "Activation of NF-kappaB in B cells" "20" "0" "1.071" "1.170" "1.351" "1.313" "1.429" "1.087" "0.840" "1.221" "5.661" "99.7" "106.8" "116.6" "134.7" "130.9" "142.5" "108.3" "83.7" "121.7" "564.5" "" "" "" "" "" "" "" "" "" "" "59.7" "55.5" "64.6" "63.2" "60.7" "72.9" "50.4" "37.6" "66.0" "564.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6148920523022948324" "False" "High" "IsMasterProtein" "P35606" "Coatomer subunit beta' OS=Homo sapiens OX=9606 GN=COPB2 PE=1 SV=2" "0.000" "False" "22.798" "7" "6" "8" "6" "906" "102.4" "5.27" "20.77" "6" "transport" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00400, Pf04053" "9276" "ENSG00000184432" "COPB2" "B4DZI8; hsa:9276; P35606" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "1.016" "0.905" "0.912" "1.017" "1.017" "0.945" "1.026" "0.989" "2.558" "179.0" "181.8" "162.1" "163.2" "182.2" "182.0" "169.3" "183.8" "177.0" "458.0" "" "" "" "" "" "" "" "" "" "" "107.2" "94.5" "89.8" "76.6" "84.4" "93.2" "78.7" "82.5" "96.0" "458.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5155041473924721713" "False" "High" "IsMasterProtein" "P48454" "Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform OS=Homo sapiens OX=9606 GN=PPP3CC PE=1 SV=3" "0.000" "False" "22.794" "13" "6" "11" "3" "512" "58.1" "6.98" "27.88" "6" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00149" "5533" "ENSG00000120910" "PPP3CC" "B4DRT5; hsa:5533; P48454; Q9BSS6; Q9H4M5" "Energy metabolism; Alzheimer's disease and miRNA effects; Amyotrophic lateral sclerosis (ALS); Initiation of transcription and translation elongation at the HIV-1 LTR; G protein signaling pathways; MAPK signaling pathway; Wnt signaling; Alzheimer's disease; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "DARPP-32 events; Activation of BAD and translocation to mitochondria" "11" "0" "1.124" "1.006" "1.137" "1.319" "1.088" "1.329" "1.013" "1.066" "1.128" "247.5" "278.2" "249.0" "281.5" "326.4" "269.2" "328.8" "250.6" "263.7" "279.2" "" "" "" "" "" "" "" "" "" "" "148.1" "144.6" "137.9" "132.1" "151.3" "137.8" "152.9" "112.5" "143.1" "279.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1492366251309725518" "False" "High" "IsMasterProtein" "Q9BZ23" "Pantothenate kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=PANK2 PE=1 SV=3" "0.000" "False" "22.792" "14" "6" "8" "4" "570" "62.6" "9.28" "22.97" "6" "other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "kinase activity;other molecular function" "Pf03630" "80025" "ENSG00000125779" "PANK2" "B1AK33; B2Z3X0; D3DVZ0; hsa:80025; Q5T7I2; Q5T7I4; Q7RTX5; Q8N7Q4; Q8TCR5; Q9BYW5; Q9BZ23; Q9HAF2" "Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Iron metabolism disorders" "Coenzyme A biosynthesis" "3" "1" "0.746" "0.862" "0.852" "0.743" "0.823" "0.774" "0.738" "0.851" "0.847" "241.7" "180.3" "208.5" "205.9" "179.7" "199.1" "187.2" "178.3" "205.6" "204.8" "" "" "" "" "" "" "" "" "" "" "144.7" "93.7" "115.4" "96.7" "83.3" "101.9" "87.0" "80.0" "111.6" "204.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2595781739747339031" "False" "High" "IsMasterProtein" "Q14677" "Clathrin interactor 1 OS=Homo sapiens OX=9606 GN=CLINT1 PE=1 SV=1" "0.000" "False" "22.788" "11" "7" "7" "7" "625" "68.2" "6.42" "17.83" "7" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01417" "9685" "ENSG00000113282" "CLINT1" "B7Z6F8; D3DQJ6; hsa:9685; Q14677; Q8NAF1; Q96E05" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "1.150" "1.184" "1.078" "1.322" "1.157" "1.236" "1.128" "1.148" "1.397" "338.6" "389.2" "401.0" "365.1" "447.6" "391.6" "418.3" "381.9" "388.6" "473.1" "" "" "" "" "" "" "" "" "" "" "202.6" "202.3" "222.1" "171.4" "207.5" "200.5" "194.5" "171.5" "210.8" "473.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6102726942936219024" "False" "High" "IsMasterProtein" "Q14152" "Eukaryotic translation initiation factor 3 subunit A OS=Homo sapiens OX=9606 GN=EIF3A PE=1 SV=1" "0.000" "False" "22.777" "6" "9" "10" "9" "1382" "166.5" "6.79" "21.20" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01399" "8661" "ENSG00000107581" "EIF3A" "B1AMV5; B4DYS1; F5H335; hsa:8661; O00653; Q14152; Q15778" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; NF1 copy number variation syndrome" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "9" "0" "1.142" "1.078" "1.085" "1.268" "1.116" "1.041" "0.925" "1.147" "3.628" "195.0" "222.7" "210.2" "211.6" "247.2" "217.6" "203.0" "180.5" "223.7" "707.5" "" "" "" "" "" "" "" "" "" "" "116.7" "115.7" "116.4" "99.4" "114.6" "111.4" "94.4" "81.0" "121.4" "707.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5554010069989842743" "False" "High" "IsMasterProtein" "Q9BZZ5" "Apoptosis inhibitor 5 OS=Homo sapiens OX=9606 GN=API5 PE=1 SV=3" "0.000" "False" "22.755" "11" "6" "24" "6" "524" "59.0" "7.34" "43.37" "6" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf05918" "8539" "ENSG00000166181" "API5" "B4DGR0; B4DRJ2; B4E283; D3DR21; G3V1C3; hsa:8539; O15441; Q9BZZ5; Q9Y4J7" "" "" "0" "0" "0.961" "0.915" "0.975" "1.388" "1.025" "1.016" "0.980" "0.962" "0.981" "1213.9" "1167.0" "1111.1" "1183.3" "1684.3" "1244.3" "1233.8" "1189.3" "1167.3" "1191.0" "" "" "" "" "" "" "" "" "" "" "726.4" "606.4" "615.3" "555.5" "780.7" "637.0" "573.7" "533.9" "633.3" "1191.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-320392191251803943" "False" "High" "IsMasterProtein" "Q9BXS6" "Nucleolar and spindle-associated protein 1 OS=Homo sapiens OX=9606 GN=NUSAP1 PE=1 SV=1" "0.000" "False" "22.754" "16" "6" "9" "6" "441" "49.4" "9.91" "26.70" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity" "Pf16006" "51203" "ENSG00000137804" "NUSAP1" "B4DDF1; E7ERR5; hsa:51203; J3KN21; Q53GW2; Q8TBT4; Q96E58; Q96FJ1; Q9BXS6; Q9GZM9; Q9NZ85; Q9UI70" "" "" "0" "0" "0.966" "0.904" "0.785" "0.919" "0.959" "0.551" "0.540" "0.625" "0.765" "369.2" "356.7" "333.6" "289.7" "339.1" "354.0" "203.6" "199.4" "230.6" "282.4" "" "" "" "" "" "" "" "" "" "" "220.9" "185.4" "184.8" "136.0" "157.2" "181.2" "94.7" "89.5" "125.1" "282.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8469309847663247920" "False" "High" "IsMasterProtein" "Q9UEY8" "Gamma-adducin OS=Homo sapiens OX=9606 GN=ADD3 PE=1 SV=1" "0.000" "False" "22.746" "11" "7" "9" "7" "706" "79.1" "6.32" "23.35" "7" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "120" "ENSG00000148700" "ADD3" "D3DRA8; hsa:120; O43243; Q5VU09; Q92773; Q9UEY7; Q9UEY8" "" "Miscellaneous transport and binding events; RHOD GTPase cycle; RHOF GTPase cycle" "3" "0" "1.047" "0.939" "0.935" "0.902" "1.152" "0.957" "0.994" "0.967" "0.658" "334.4" "350.2" "313.8" "312.8" "301.7" "385.1" "319.9" "332.4" "323.2" "219.9" "" "" "" "" "" "" "" "" "" "" "200.1" "182.0" "173.8" "146.8" "139.9" "197.1" "148.7" "149.2" "175.4" "219.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1597744866915900932" "False" "High" "IsMasterProtein" "P51114" "RNA-binding protein FXR1 OS=Homo sapiens OX=9606 GN=FXR1 PE=1 SV=3" "0.000" "False" "22.667" "12" "6" "7" "6" "621" "69.7" "6.15" "17.76" "6" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16096, Pf16097, Pf17904, Pf18336" "8087" "ENSG00000114416" "FXR1" "A8K9B8; hsa:8087; P51114; Q7Z450; Q8N6R8" "Bile acids synthesis and enterohepatic circulation" "Signaling by BRAF and RAF1 fusions" "2" "0" "1.061" "1.033" "1.082" "1.166" "1.084" "0.915" "0.811" "1.303" "6.069" "162.1" "172.1" "167.5" "175.4" "189.0" "175.8" "148.3" "131.5" "211.2" "984.1" "" "" "" "" "" "" "" "" "" "" "97.0" "89.4" "92.7" "82.4" "87.6" "90.0" "69.0" "59.0" "114.6" "984.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-644721245290312006" "False" "High" "IsMasterProtein" "Q9UNS2" "COP9 signalosome complex subunit 3 OS=Homo sapiens OX=9606 GN=COPS3 PE=1 SV=3" "0.000" "False" "22.638" "19" "7" "14" "7" "423" "47.8" "6.65" "33.83" "7" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf21215" "8533" "ENSG00000141030" "COPS3" "B2R683; B4DY81; hsa:8533; O43191; Q7LDR6; Q9UNS2" "Ciliary landscape; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER" "6" "0" "1.143" "1.074" "0.963" "1.108" "1.035" "0.923" "1.029" "1.044" "0.673" "561.0" "641.3" "602.3" "540.2" "621.4" "580.5" "517.7" "577.3" "585.5" "377.8" "" "" "" "" "" "" "" "" "" "" "335.7" "333.2" "333.6" "253.6" "288.0" "297.2" "240.7" "259.2" "317.7" "377.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8198800325193539681" "False" "High" "IsMasterProtein" "P30050" "Large ribosomal subunit protein uL11 OS=Homo sapiens OX=9606 GN=RPL12 PE=1 SV=1" "0.000" "False" "22.635" "36" "5" "11" "5" "165" "17.8" "9.42" "30.70" "5" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00298, Pf03946" "6136" "ENSG00000197958" "RPL12" "hsa:6136; P30050; Q5VVV2; Q6PB27" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.716" "0.821" "0.802" "0.744" "0.977" "0.936" "0.962" "0.944" "0.226" "144.5" "103.5" "118.6" "115.9" "107.6" "141.2" "135.3" "139.0" "136.5" "32.7" "" "" "" "" "" "" "" "" "" "" "86.5" "53.8" "65.7" "54.4" "49.9" "72.3" "62.9" "62.4" "74.0" "32.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6570966043889327404" "False" "High" "IsMasterProtein" "Q15437" "Protein transport protein Sec23B OS=Homo sapiens OX=9606 GN=SEC23B PE=1 SV=2" "0.000" "False" "22.598" "10" "7" "11" "6" "767" "86.4" "6.89" "23.23" "7" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10483" "ENSG00000101310" "SEC23B" "D3DW33; hsa:10483; Q15437; Q503A9; Q5W183; Q9BS15; Q9BSI2; Q9H1D7" "Sterol regulatory element-binding proteins (SREBP) signaling" "" "1" "1" "0.989" "1.007" "1.040" "0.961" "1.058" "0.999" "0.973" "0.984" "1.530" "311.6" "308.2" "313.8" "324.0" "299.5" "329.6" "311.3" "303.1" "306.5" "476.8" "" "" "" "" "" "" "" "" "" "" "186.5" "160.2" "173.8" "152.1" "138.8" "168.7" "144.7" "136.1" "166.3" "476.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5820221568948669859" "False" "High" "IsMasterProtein" "P61081" "NEDD8-conjugating enzyme Ubc12 OS=Homo sapiens OX=9606 GN=UBE2M PE=1 SV=1" "0.000" "False" "22.566" "27" "5" "12" "5" "183" "20.9" "7.69" "29.78" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "9040" "ENSG00000130725" "UBE2M" "hsa:9040; O76069; P61081; Q8VC50" "" "Antigen processing: Ubiquitination & Proteasome degradation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Neddylation; TGF-beta receptor signaling activates SMADs" "5" "0" "1.083" "1.107" "0.958" "1.223" "1.107" "1.055" "0.972" "1.138" "2.793" "298.4" "323.3" "330.3" "285.8" "365.0" "330.3" "314.8" "290.2" "339.6" "833.6" "" "" "" "" "" "" "" "" "" "" "178.6" "168.0" "182.9" "134.2" "169.2" "169.1" "146.4" "130.3" "184.3" "833.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4780754661784181438" "False" "High" "IsMasterProtein" "O95373" "Importin-7 OS=Homo sapiens OX=9606 GN=IPO7 PE=1 SV=1" "0.000" "False" "22.545" "5" "5" "12" "5" "1038" "119.4" "4.82" "36.05" "5" "stress response;transport;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf03810, Pf08506" "10527" "ENSG00000205339" "IPO7" "A6NNM5; B2R786; hsa:10527; O95373; Q1RMF7; Q9H177; Q9NTE3" "" "" "0" "0" "1.172" "1.281" "1.156" "1.172" "1.234" "1.154" "0.920" "1.222" "4.571" "261.8" "306.9" "335.3" "302.6" "306.7" "323.0" "302.1" "240.9" "320.0" "1196.9" "" "" "" "" "" "" "" "" "" "" "156.7" "159.5" "185.7" "142.0" "142.2" "165.3" "140.5" "108.1" "173.6" "1196.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4632135778776149030" "False" "High" "IsMasterProtein" "P18085" "ADP-ribosylation factor 4 OS=Homo sapiens OX=9606 GN=ARF4 PE=1 SV=3" "0.000" "False" "22.542" "31" "5" "20" "3" "180" "20.5" "7.14" "46.89" "5" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00025" "378" "ENSG00000168374" "ARF4" "B2R7J7; hsa:378; P18085; P21371" "VEGFA-VEGFR2 signaling" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; VxPx cargo-targeting to cilium" "4" "0" "1.051" "0.963" "1.070" "1.289" "0.967" "1.273" "0.963" "1.151" "1.737" "420.5" "442.1" "404.9" "450.1" "542.1" "406.8" "535.1" "405.0" "483.8" "730.2" "" "" "" "" "" "" "" "" "" "" "251.6" "229.7" "224.2" "211.3" "251.3" "208.2" "248.8" "181.8" "262.5" "730.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7811403610276720073" "False" "High" "IsMasterProtein" "Q99543" "DnaJ homolog subfamily C member 2 OS=Homo sapiens OX=9606 GN=DNAJC2 PE=1 SV=4" "0.000" "False" "22.540" "10" "6" "6" "6" "621" "72.0" "8.70" "18.15" "6" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "translation activity;other molecular function" "Pf00226, Pf00249, Pf16717" "27000" "ENSG00000105821" "DNAJC2" "A4VCI0; hsa:27000; Q99543; Q9BVX1" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "1.147" "1.032" "1.231" "1.003" "1.337" "1.156" "0.720" "1.069" "5.888" "78.8" "90.4" "81.3" "97.1" "79.0" "105.4" "91.1" "56.7" "84.2" "464.0" "" "" "" "" "" "" "" "" "" "" "47.2" "47.0" "45.0" "45.6" "36.6" "54.0" "42.4" "25.5" "45.7" "464.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7556916282893625233" "False" "High" "IsMasterProtein" "O15347" "High mobility group protein B3 OS=Homo sapiens OX=9606 GN=HMGB3 PE=1 SV=4" "0.000" "False" "22.523" "18" "2" "4" "2" "200" "23.0" "8.37" "14.86" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00505, Pf09011" "3149" "ENSG00000029993" "HMGB3" "hsa:3149; O15347; O95556; Q6NS40" "" "" "0" "0" "1.032" "1.066" "0.966" "1.099" "1.114" "0.993" "1.081" "0.948" "0.436" "737.2" "760.4" "785.5" "712.1" "810.4" "821.5" "731.8" "796.6" "699.2" "321.7" "" "" "" "" "" "" "" "" "" "" "441.2" "395.2" "435.0" "334.3" "375.6" "420.5" "340.3" "357.6" "379.4" "321.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7827642572833014462" "False" "High" "IsMasterProtein" "P14649" "Myosin light chain 6B OS=Homo sapiens OX=9606 GN=MYL6B PE=1 SV=1" "0.000" "False" "22.487" "19" "4" "17" "2" "208" "22.8" "5.73" "33.80" "4" "other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "" "140465" "ENSG00000196465" "MYL6B" "hsa:140465; P14649" "Ciliary landscape" "Smooth Muscle Contraction" "2" "0" "0.933" "1.102" "1.194" "1.173" "1.213" "1.528" "1.408" "1.401" "0.728" "37.5" "35.0" "41.3" "44.7" "43.9" "45.4" "57.2" "52.8" "52.5" "27.3" "" "" "" "" "" "" "" "" "" "" "22.4" "18.2" "22.9" "21.0" "20.4" "23.3" "26.6" "23.7" "28.5" "27.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8737911317243548471" "False" "High" "IsMasterProtein" "Q15631" "Translin OS=Homo sapiens OX=9606 GN=TSN PE=1 SV=1" "0.000" "False" "22.448" "24" "6" "14" "6" "228" "26.2" "6.44" "42.69" "6" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01997" "7247" "ENSG00000211460" "TSN" "B7Z3X8; hsa:7247; Q15631; Q5U0K7" "" "Small interfering RNA (siRNA) biogenesis" "1" "0" "1.003" "0.965" "1.026" "0.918" "1.027" "0.930" "1.068" "0.976" "0.806" "817.5" "820.3" "788.6" "838.6" "750.5" "839.5" "760.3" "872.7" "798.3" "659.3" "" "" "" "" "" "" "" "" "" "" "489.2" "426.3" "436.7" "393.7" "347.9" "429.7" "353.5" "391.8" "433.1" "659.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6421392599925785436" "False" "High" "IsMasterProtein" "Q9HD15" "Steroid receptor RNA activator 1 OS=Homo sapiens OX=9606 GN=SRA1 PE=1 SV=2" "0.000" "False" "22.441" "26" "6" "8" "6" "224" "24.4" "7.50" "23.82" "6" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07304" "10011" "ENSG00000213523" "SRA1" "hsa:10011; Q6NVU9; Q8IXM1; Q9HD13; Q9HD14; Q9HD15" "" "" "0" "0" "1.019" "1.133" "1.205" "1.221" "1.139" "1.264" "1.142" "1.065" "0.896" "338.3" "344.9" "383.3" "407.6" "413.1" "385.4" "427.6" "386.4" "360.3" "303.0" "" "" "" "" "" "" "" "" "" "" "202.4" "179.2" "212.3" "191.4" "191.5" "197.3" "198.8" "173.5" "195.5" "303.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7881821209807726399" "False" "High" "IsMasterProtein" "O75153" "Clustered mitochondria protein homolog OS=Homo sapiens OX=9606 GN=CLUH PE=1 SV=2" "0.000" "False" "22.403" "7" "8" "10" "8" "1309" "146.6" "6.13" "20.08" "8" "cell organization and biogenesis" "other cell component" "nucleic acid binding activity" "Pf12807, Pf13236, Pf13374, Pf13424, Pf15044" "23277" "ENSG00000132361" "CLUH" "hsa:23277; O75153; Q6AHY2; Q6P3X7; Q6ZUG8; Q8N4U7; Q9BTA3; Q9H979" "Translation factors" "" "1" "0" "0.921" "0.972" "0.777" "0.958" "1.096" "0.989" "0.485" "1.094" "6.516" "102.5" "94.4" "99.6" "79.6" "98.2" "112.3" "101.3" "49.7" "112.1" "667.7" "" "" "" "" "" "" "" "" "" "" "61.3" "49.0" "55.2" "37.4" "45.5" "57.5" "47.1" "22.3" "60.8" "667.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5299507636150983864" "False" "High" "IsMasterProtein" "Q9Y697" "Cysteine desulfurase OS=Homo sapiens OX=9606 GN=NFS1 PE=1 SV=3" "0.000" "False" "22.316" "15" "6" "10" "6" "457" "50.2" "8.31" "26.09" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00266" "9054" "ENSG00000244005" "NFS1" "B3KMA5; B4DXK9; E1P5R8; F5GYK5; hsa:9054; Q6P0L8; Q9NTZ5; Q9Y481; Q9Y697" "Iron-sulfur cluster biogenesis" "" "1" "0" "1.013" "0.997" "1.002" "1.022" "1.077" "0.995" "1.059" "1.078" "0.837" "641.5" "649.8" "639.8" "642.8" "655.5" "691.1" "638.3" "679.6" "691.4" "536.7" "" "" "" "" "" "" "" "" "" "" "383.9" "337.7" "354.3" "301.8" "303.8" "353.8" "296.8" "305.1" "375.1" "536.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6167412320153067815" "False" "High" "IsMasterProtein" "P35613" "Basigin OS=Homo sapiens OX=9606 GN=BSG PE=1 SV=2" "0.000" "False" "22.301" "18" "6" "8" "6" "385" "42.2" "5.66" "23.29" "6" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13927" "682" "ENSG00000172270" "BSG" "A6NJW1; D3YLG5; hsa:682; P35613; Q7Z796; Q8IZL7" "Matrix metalloproteinases; VEGFA-VEGFR2 signaling; IL-18 signaling pathway" "Degradation of the extracellular matrix; Integrin cell surface interactions; Pyruvate metabolism; Aspirin ADME; Basigin interactions; Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)" "10" "0" "1.082" "0.990" "1.014" "1.123" "1.035" "1.107" "1.221" "1.272" "0.662" "731.3" "791.2" "723.8" "741.3" "821.5" "757.0" "809.2" "892.9" "930.5" "484.4" "" "" "" "" "" "" "" "" "" "" "437.6" "411.2" "400.8" "348.0" "380.8" "387.5" "376.3" "400.9" "504.8" "484.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8110306690791428834" "False" "High" "IsMasterProtein" "P29218" "Inositol monophosphatase 1 OS=Homo sapiens OX=9606 GN=IMPA1 PE=1 SV=1" "0.000" "False" "22.300" "17" "4" "13" "4" "277" "30.2" "5.26" "35.85" "4" "other metabolic processes;signal transduction" "cytosol;other cell component" "other molecular function" "Pf00459" "3612" "ENSG00000133731" "IMPA1" "B2R733; B4DLN3; B7Z6Q4; J3KQT7; P29218; Q9UK71" "" "Synthesis of IP2, IP, and Ins in the cytosol" "1" "0" "0.928" "0.942" "1.066" "1.054" "0.972" "1.027" "0.988" "1.038" "0.668" "542.1" "503.1" "510.4" "577.8" "571.5" "527.1" "556.7" "535.3" "562.9" "362.0" "" "" "" "" "" "" "" "" "" "" "324.4" "261.4" "282.7" "271.3" "264.9" "269.8" "258.8" "240.3" "305.4" "362.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5620405547330282270" "False" "High" "IsMasterProtein" "Q7Z4V5" "Hepatoma-derived growth factor-related protein 2 OS=Homo sapiens OX=9606 GN=HDGFL2 PE=1 SV=1" "0.000" "False" "22.275" "11" "7" "13" "6" "671" "74.3" "7.49" "33.41" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00855, Pf11467" "84717" "ENSG00000167674" "HDGFL2" "I3L080; K7EQZ6; Q7Z4V5; Q96GI5; Q9BW08" "" "" "0" "0" "0.940" "0.948" "0.805" "1.022" "0.895" "0.833" "0.824" "0.839" "0.454" "477.4" "448.9" "452.6" "384.4" "487.9" "427.1" "397.8" "393.4" "400.5" "216.5" "" "" "" "" "" "" "" "" "" "" "285.7" "233.3" "250.6" "180.4" "226.2" "218.6" "185.0" "176.6" "217.3" "216.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5459643991948160099" "False" "High" "IsMasterProtein" "Q9NWH9" "SAFB-like transcription modulator OS=Homo sapiens OX=9606 GN=SLTM PE=1 SV=2" "0.000" "False" "22.183" "9" "9" "12" "9" "1034" "117.1" "7.87" "19.59" "9" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf02037" "79811" "ENSG00000137776" "SLTM" "A8K5V8; B2RTX3; hsa:79811; Q2VPK7; Q52MB3; Q658J7; Q6ZNF2; Q86TK6; Q9H7C3; Q9H8U9; Q9NWH9" "" "" "0" "0" "1.029" "0.863" "1.053" "1.022" "1.009" "0.989" "1.073" "1.040" "0.664" "531.2" "546.4" "458.3" "559.2" "543.0" "536.1" "525.2" "570.0" "552.5" "352.5" "" "" "" "" "" "" "" "" "" "" "317.9" "283.9" "253.8" "262.5" "251.7" "274.4" "244.2" "255.9" "299.8" "352.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2767928129327746769" "False" "High" "IsMasterProtein" "O14950" "Myosin regulatory light chain 12B OS=Homo sapiens OX=9606 GN=MYL12B PE=1 SV=2" "0.000" "False" "22.146" "30" "5" "22" "5" "172" "19.8" "4.84" "39.16" "5" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf08976, Pf13499" "103910; 10627" "ENSG00000118680" "MYL12B" "D3DUH6; hsa:103910; O14950; Q13182; Q7Z5Z4" "Thyroid stimulating hormone (TSH) signaling pathway; Focal adhesion" "RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "9" "0" "1.057" "0.976" "1.073" "1.207" "1.120" "1.232" "1.153" "1.077" "1.118" "1073.9" "1134.9" "1048.6" "1151.9" "1295.9" "1203.0" "1322.7" "1238.4" "1156.3" "1200.7" "" "" "" "" "" "" "" "" "" "" "642.7" "589.8" "580.7" "540.8" "600.7" "615.8" "615.0" "556.0" "627.3" "1200.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5669236386910036788" "False" "High" "IsMasterProtein" "P46783" "Small ribosomal subunit protein eS10 OS=Homo sapiens OX=9606 GN=RPS10 PE=1 SV=1" "0.000" "False" "22.121" "20" "4" "6" "4" "165" "18.9" "10.15" "17.23" "4" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf03501" "6204" "ENSG00000124614" "RPS10" "B2R4E3; hsa:6204; P46783; Q5TZC0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "1.057" "1.025" "1.058" "0.950" "0.886" "0.936" "0.870" "0.906" "1.377" "411.4" "434.8" "421.7" "435.4" "390.7" "364.4" "385.0" "357.9" "373.0" "566.5" "" "" "" "" "" "" "" "" "" "" "246.2" "225.9" "233.6" "204.4" "181.1" "186.6" "179.0" "160.7" "202.3" "566.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4783590985173723979" "False" "High" "IsMasterProtein" "Q96CN7" "Isochorismatase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ISOC1 PE=1 SV=3" "0.000" "False" "22.120" "19" "5" "12" "5" "298" "32.2" "7.39" "28.71" "5" "" "other cytoplasmic organelle;other cell component" "" "Pf00857" "51015" "ENSG00000066583" "ISOC1" "hsa:51015; Q7Z770; Q96CN7" "" "" "0" "0" "1.018" "0.943" "1.014" "1.025" "1.031" "0.962" "1.037" "1.003" "0.708" "297.9" "303.2" "281.0" "302.0" "305.4" "307.2" "286.6" "309.0" "298.7" "211.0" "" "" "" "" "" "" "" "" "" "" "178.3" "157.6" "155.6" "141.8" "141.6" "157.3" "133.2" "138.7" "162.1" "211.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1581896134396951467" "False" "High" "IsMasterProtein" "P49006" "MARCKS-related protein OS=Homo sapiens OX=9606 GN=MARCKSL1 PE=1 SV=2" "0.000" "False" "22.101" "18" "4" "18" "4" "195" "19.5" "4.67" "51.79" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02063" "65108" "ENSG00000175130" "MARCKSL1" "D3DPQ0; hsa:65108; P49006; Q5TEE6; Q6NXS5" "" "" "0" "0" "1.002" "1.027" "0.960" "0.951" "0.963" "1.050" "1.122" "0.993" "0.401" "1987.9" "1992.5" "2042.1" "1908.5" "1891.2" "1914.5" "2087.0" "2231.0" "1973.1" "796.2" "" "" "" "" "" "" "" "" "" "" "1189.6" "1035.4" "1130.8" "896.0" "876.6" "980.1" "970.4" "1001.6" "1070.5" "796.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5794288011295636240" "False" "High" "IsMasterProtein" "O60502" "Protein O-GlcNAcase OS=Homo sapiens OX=9606 GN=OGA PE=1 SV=2" "0.000" "False" "22.097" "8" "8" "9" "8" "916" "102.8" "4.91" "24.31" "8" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf07555" "10724" "ENSG00000198408" "OGA" "B7WPB9; D3DR79; E9PGF9; hsa:10724; O60502; O75166; Q86WV0; Q8IV98; Q9BVA5; Q9HAR0" "" "" "0" "0" "1.084" "1.072" "1.002" "1.052" "1.043" "0.980" "0.988" "1.057" "1.109" "973.7" "1055.1" "1043.7" "975.7" "1023.9" "1015.5" "954.0" "961.7" "1028.7" "1079.4" "" "" "" "" "" "" "" "" "" "" "582.7" "548.3" "578.0" "458.0" "474.6" "519.9" "443.6" "431.7" "558.1" "1079.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3138004166962983246" "False" "High" "IsMasterProtein" "Q92688" "Acidic leucine-rich nuclear phosphoprotein 32 family member B OS=Homo sapiens OX=9606 GN=ANP32B PE=1 SV=1" "0.000" "False" "22.051" "28" "6" "17" "3" "251" "28.8" "4.06" "34.41" "6" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12799" "10541" "ENSG00000136938" "ANP32B" "B2R9C7; hsa:10541; O00655; P78458; P78459; Q92688" "" "" "0" "0" "0.983" "1.027" "0.896" "0.835" "0.798" "0.792" "0.659" "0.781" "1.220" "319.9" "314.5" "328.6" "286.6" "267.1" "255.1" "253.5" "210.9" "249.9" "390.3" "" "" "" "" "" "" "" "" "" "" "191.4" "163.4" "182.0" "134.6" "123.8" "130.6" "117.9" "94.7" "135.6" "390.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2657182436335150623" "False" "High" "IsMasterProtein" "Q9Y3I0" "RNA-splicing ligase RtcB homolog OS=Homo sapiens OX=9606 GN=RTCB PE=1 SV=1" "0.000" "False" "22.047" "11" "5" "6" "5" "505" "55.2" "7.23" "19.11" "5" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01139" "51493" "ENSG00000100220" "RTCB" "B2R6A8; hsa:51493; Q6IAI0; Q9BWL4; Q9NTH1; Q9P037; Q9P0J3; Q9Y3I0" "Unfolded protein response" "tRNA processing in the nucleus" "2" "0" "1.199" "1.062" "1.204" "1.002" "0.989" "1.254" "1.074" "1.077" "1.024" "366.1" "438.9" "388.7" "440.7" "366.6" "361.9" "459.0" "393.0" "394.3" "375.0" "" "" "" "" "" "" "" "" "" "" "219.1" "228.1" "215.2" "206.9" "169.9" "185.3" "213.4" "176.4" "213.9" "375.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7873771796286241695" "False" "High" "IsMasterProtein" "A6NHL2" "Tubulin alpha chain-like 3 OS=Homo sapiens OX=9606 GN=TUBAL3 PE=1 SV=2" "0.000" "False" "21.998" "10" "4" "18" "1" "446" "49.9" "6.05" "46.09" "4" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "79861" "ENSG00000178462" "TUBAL3" "A6NHL2; B4DKL2; hsa:79861; Q4QQJ5; Q9H6Z0" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; Cilium Assembly; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling" "32" "0" "0.999" "0.834" "0.959" "0.899" "1.157" "0.926" "1.097" "0.988" "0.532" "136.0" "135.8" "113.4" "130.5" "122.2" "157.3" "126.0" "149.2" "134.3" "72.4" "" "" "" "" "" "" "" "" "" "" "81.4" "70.6" "62.8" "61.3" "56.7" "80.5" "58.6" "67.0" "72.9" "72.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6065007746744177820" "False" "High" "IsMasterProtein" "Q9ULZ2" "Signal-transducing adaptor protein 1 OS=Homo sapiens OX=9606 GN=STAP1 PE=1 SV=1" "0.000" "False" "21.974" "18" "6" "7" "6" "295" "34.3" "7.77" "19.31" "6" "signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00169" "26228" "ENSG00000035720" "STAP1" "B2R980; hsa:26228; Q9ULZ2" "" "" "0" "0" "1.101" "1.211" "1.190" "1.202" "1.088" "1.203" "0.677" "1.129" "7.333" "183.4" "202.0" "222.2" "218.2" "220.6" "199.6" "220.7" "124.2" "207.0" "1345.0" "" "" "" "" "" "" "" "" "" "" "109.8" "104.9" "123.1" "102.5" "102.2" "102.2" "102.6" "55.8" "112.3" "1345.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2591568921065242388" "False" "High" "IsMasterProtein" "Q8NB90" "ATPase family gene 2 protein homolog A OS=Homo sapiens OX=9606 GN=AFG2A PE=1 SV=3" "0.000" "False" "21.917" "9" "7" "19" "6" "893" "97.8" "5.66" "36.67" "7" "developmental processes;other biological processes" "cytoskeleton;mitochondrion;other cell component" "other molecular function" "Pf00004, Pf17862" "166378" "ENSG00000145375" "AFG2A" "C9JT97; hsa:166378; Q86XW1; Q8NB90; Q8NI20; Q8TDL7" "" "" "0" "0" "1.075" "1.010" "1.049" "1.035" "1.103" "1.087" "0.989" "0.986" "0.902" "394.1" "423.8" "398.1" "413.5" "407.8" "434.7" "428.5" "389.8" "388.6" "355.4" "" "" "" "" "" "" "" "" "" "" "235.8" "220.2" "220.5" "194.1" "189.0" "222.5" "199.2" "175.0" "210.9" "355.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6767865713948388298" "False" "High" "IsMasterProtein" "P49720" "Proteasome subunit beta type-3 OS=Homo sapiens OX=9606 GN=PSMB3 PE=1 SV=2" "0.000" "False" "21.910" "30" "5" "16" "5" "205" "22.9" "6.55" "49.77" "5" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00227" "5691" "ENSG00000275903; ENSG00000277791" "PSMB3" "hsa:5691; P31147; P49720; Q0P6J7; Q96E27" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Separation of Sister Chromatids; Neddylation; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.936" "1.013" "1.067" "0.925" "0.995" "0.940" "1.097" "0.978" "0.621" "1461.5" "1367.7" "1480.3" "1559.6" "1351.9" "1454.1" "1373.3" "1603.0" "1429.7" "907.3" "" "" "" "" "" "" "" "" "" "" "874.6" "710.7" "819.8" "732.2" "626.6" "744.4" "638.5" "719.7" "775.7" "907.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1987024820899376297" "False" "High" "IsMasterProtein" "Q9BRA2" "Thioredoxin domain-containing protein 17 OS=Homo sapiens OX=9606 GN=TXNDC17 PE=1 SV=1" "0.000" "False" "21.894" "44" "5" "19" "5" "123" "13.9" "5.52" "46.00" "5" "signal transduction;other biological processes" "cytosol" "other molecular function" "Pf06110" "84817" "ENSG00000129235" "TXNDC17" "A8K7E8; hsa:84817; Q9BRA2" "" "" "0" "0" "1.060" "1.186" "1.087" "1.081" "1.094" "1.032" "1.070" "1.097" "1.167" "971.2" "1029.0" "1151.4" "1055.4" "1049.9" "1062.8" "1002.0" "1039.7" "1065.0" "1133.2" "" "" "" "" "" "" "" "" "" "" "581.2" "534.7" "637.6" "495.5" "486.7" "544.1" "465.9" "466.7" "577.8" "1133.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1099504193891774007" "False" "High" "IsMasterProtein" "Q13557" "Calcium/calmodulin-dependent protein kinase type II subunit delta OS=Homo sapiens OX=9606 GN=CAMK2D PE=1 SV=3" "0.000" "False" "21.887" "12" "6" "13" "6" "499" "56.3" "7.25" "30.61" "6" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08332" "817" "ENSG00000145349" "CAMK2D" "A8MVS8; hsa:817; Q13557; Q52PK4; Q59G21; Q8N553; Q9UGH6; Q9UQE9" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; SRF and miRs in smooth muscle differentiation and proliferation; Cardiac hypertrophic response; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Affected pathways in Duchenne muscular dystrophy; Calcium regulation in cardiac cells; ErbB signaling pathway" "Signaling by BRAF and RAF1 fusions; Assembly and cell surface presentation of NMDA receptors; Ion homeostasis; Ion transport by P-type ATPases; Interferon gamma signaling; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; Regulation of MECP2 expression and activity; Unblocking of NMDA receptors, glutamate binding and activation; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Phase 0 - rapid depolarisation; HSF1-dependent transactivation; CaMK IV-mediated phosphorylation of CREB" "33" "0" "1.037" "1.084" "1.137" "1.028" "1.182" "1.034" "0.990" "1.097" "1.572" "741.1" "768.5" "803.1" "843.0" "761.6" "875.9" "766.6" "733.9" "812.7" "1164.7" "" "" "" "" "" "" "" "" "" "" "443.5" "399.4" "444.7" "395.7" "353.0" "448.4" "356.4" "329.5" "440.9" "1164.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1626409123411173154" "False" "High" "IsMasterProtein" "Q99598" "Translin-associated protein X OS=Homo sapiens OX=9606 GN=TSNAX PE=1 SV=1" "0.000" "False" "21.880" "23" "7" "9" "7" "290" "33.1" "6.55" "24.21" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf01997" "7257" "ENSG00000116918" "TSNAX" "B1APC6; hsa:7257; Q99598" "" "Small interfering RNA (siRNA) biogenesis" "1" "0" "0.970" "0.989" "0.926" "0.960" "0.952" "1.037" "1.014" "1.026" "0.577" "673.3" "652.9" "666.0" "623.2" "646.6" "641.1" "698.3" "683.0" "690.8" "388.3" "" "" "" "" "" "" "" "" "" "" "402.9" "339.3" "368.8" "292.6" "299.7" "328.2" "324.7" "306.6" "374.8" "388.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516801179277526941" "False" "High" "IsMasterProtein" "Q9HB71" "Calcyclin-binding protein OS=Homo sapiens OX=9606 GN=CACYBP PE=1 SV=2" "0.000" "False" "21.857" "19" "6" "22" "6" "228" "26.2" "8.25" "59.09" "6" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf04969, Pf05002, Pf09032" "27101" "ENSG00000116161" "CACYBP" "B2ZWH2; B3KSF1; hsa:27101; O60666; Q5R370; Q5R371; Q9HB71" "Gastric cancer network 2" "" "1" "0" "1.119" "1.128" "1.026" "1.013" "0.956" "1.063" "1.016" "1.049" "1.392" "1587.8" "1777.2" "1791.8" "1628.9" "1608.3" "1517.2" "1687.7" "1613.1" "1666.3" "2210.9" "" "" "" "" "" "" "" "" "" "" "950.2" "923.5" "992.2" "764.7" "745.5" "776.7" "784.8" "724.2" "904.1" "2210.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6844923263172623256" "False" "High" "IsMasterProtein" "Q9BXP5" "Serrate RNA effector molecule homolog OS=Homo sapiens OX=9606 GN=SRRT PE=1 SV=1" "0.000" "False" "21.838" "8" "7" "8" "7" "876" "100.6" "5.96" "17.96" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04959, Pf12066" "51593" "ENSG00000087087" "SRRT" "A4D2E5; A4D2E6; A6NK22; B4DJL4; B4DZA6; hsa:51593; O95808; Q32MI4; Q6NT74; Q8TDQ5; Q9BWP6; Q9BXP4; Q9BXP5; Q9Y4S4" "" "mRNA Splicing - Major Pathway; RNA polymerase II transcribes snRNA genes" "2" "0" "1.014" "0.999" "1.042" "1.277" "1.015" "1.066" "0.701" "0.954" "5.658" "224.2" "227.3" "224.0" "233.7" "286.4" "227.5" "239.0" "157.2" "213.9" "1268.7" "" "" "" "" "" "" "" "" "" "" "134.2" "118.1" "124.1" "109.7" "132.8" "116.5" "111.1" "70.6" "116.0" "1268.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3834517730795482410" "False" "High" "IsMasterProtein" "Q05655" "Protein kinase C delta type OS=Homo sapiens OX=9606 GN=PRKCD PE=1 SV=2" "0.000" "False" "21.831" "10" "7" "10" "7" "676" "77.5" "7.75" "28.35" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00130, Pf00433, Pf21494" "5580" "ENSG00000163932" "PRKCD" "B0KZ81; B2R834; hsa:5580; Q05655; Q15144; Q86XJ6" "Type II diabetes mellitus; Glioblastoma signaling pathways; B cell receptor signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; IL6 signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Wnt signaling pathway and pluripotency; Pancreatic adenocarcinoma pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Galanin receptor pathway; Orexin receptor pathway; CCL18 signaling pathway; Chronic hyperglycemia impairment of neuron function; TROP2 regulatory signaling; Calcium regulation in cardiac cells; Type II interferon signaling; T-cell receptor signaling pathway" "CLEC7A (Dectin-1) signaling; KEAP1-NFE2L2 pathway; Neutrophil degranulation; Interferon gamma signaling; VEGFR2 mediated cell proliferation; Role of phospholipids in phagocytosis; G alpha (z) signalling events; SHC1 events in ERBB2 signaling; HuR (ELAVL1) binds and stabilizes mRNA; DAG and IP3 signaling; Effects of PIP2 hydrolysis; RHO GTPases Activate NADPH Oxidases; Calmodulin induced events; Apoptotic cleavage of cellular proteins" "47" "0" "1.014" "0.970" "1.113" "1.101" "1.017" "1.070" "0.923" "0.975" "1.870" "444.0" "450.1" "430.5" "494.0" "489.0" "451.4" "474.8" "409.9" "433.0" "830.3" "" "" "" "" "" "" "" "" "" "" "265.7" "233.9" "238.4" "231.9" "226.6" "231.1" "220.8" "184.0" "234.9" "830.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6341568024441871550" "False" "High" "IsMasterProtein" "O75131" "Copine-3 OS=Homo sapiens OX=9606 GN=CPNE3 PE=1 SV=1" "0.000" "False" "21.818" "15" "8" "15" "8" "537" "60.1" "5.85" "27.42" "8" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00168, Pf07002" "8895" "ENSG00000085719" "CPNE3" "A8KA47; hsa:8895; O75131; Q8IYA1" "" "Neutrophil degranulation; Glycerophospholipid biosynthesis" "2" "0" "0.914" "1.020" "1.088" "0.999" "1.137" "0.966" "0.734" "1.037" "2.652" "757.2" "692.4" "772.4" "824.2" "756.3" "861.3" "731.2" "555.6" "785.1" "2008.0" "" "" "" "" "" "" "" "" "" "" "453.2" "359.8" "427.7" "386.9" "350.6" "440.9" "340.0" "249.4" "425.9" "2008.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5706954355209209913" "False" "High" "IsMasterProtein" "Q99436" "Proteasome subunit beta type-7 OS=Homo sapiens OX=9606 GN=PSMB7 PE=1 SV=1" "0.000" "False" "21.738" "19" "5" "15" "5" "277" "29.9" "7.68" "31.85" "5" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf12465" "5695" "ENSG00000136930" "PSMB7" "B4E0P1; hsa:5695; Q5TBG6; Q96AG8; Q99436; Q9BWA7" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "ER-Phagosome pathway; Neutrophil degranulation; MAPK6/MAPK4 signaling; FCERI mediated NF-kB activation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "0.983" "1.042" "1.079" "0.973" "0.909" "1.018" "1.102" "1.045" "0.582" "1647.6" "1619.1" "1717.0" "1777.2" "1603.8" "1497.1" "1677.6" "1815.0" "1721.8" "959.2" "" "" "" "" "" "" "" "" "" "" "986.0" "841.4" "950.8" "834.3" "743.4" "766.4" "780.0" "814.8" "934.2" "959.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9188891296985920952" "False" "High" "IsMasterProtein" "P31483" "Cytotoxic granule associated RNA binding protein TIA1 OS=Homo sapiens OX=9606 GN=TIA1 PE=1 SV=3" "0.000" "False" "21.733" "19" "6" "11" "3" "386" "42.9" "7.74" "20.89" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "7072" "ENSG00000116001" "TIA1" "hsa:7072; P31483; Q53SS9; Q96B58" "" "FGFR2 alternative splicing" "1" "2" "1.157" "1.197" "1.133" "1.420" "1.210" "1.107" "1.059" "1.305" "1.035" "153.3" "177.4" "183.5" "173.7" "217.6" "185.5" "169.6" "162.3" "200.0" "158.7" "" "" "" "" "" "" "" "" "" "" "91.7" "92.2" "101.6" "81.5" "100.9" "95.0" "78.9" "72.9" "108.5" "158.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5199956621996248182" "False" "High" "IsMasterProtein" "P18859" "ATP synthase-coupling factor 6, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PF PE=1 SV=1" "0.000" "False" "21.663" "39" "4" "7" "4" "108" "12.6" "9.52" "22.38" "4" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05511" "522" "ENSG00000154723" "ATP5PF" "hsa:522; J3KQ83; P18859" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "5" "0" "0.965" "1.031" "0.844" "1.084" "0.917" "1.006" "1.049" "0.925" "0.210" "443.6" "428.0" "457.4" "374.5" "480.9" "406.9" "446.4" "465.1" "410.3" "93.2" "" "" "" "" "" "" "" "" "" "" "265.5" "222.4" "253.3" "175.8" "222.9" "208.3" "207.6" "208.8" "222.6" "93.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3797665255168145849" "False" "High" "IsMasterProtein" "P46087" "28S rRNA (cytosine(4447)-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NOP2 PE=1 SV=2" "0.000" "False" "21.633" "7" "5" "8" "5" "812" "89.2" "9.23" "21.77" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01189, Pf08062, Pf17125" "4839" "ENSG00000111641" "NOP2" "A1A4Z3; B3KPD6; hsa:4839; P46087; Q05BA7; Q0P5S5; Q3KQS4; Q58F30" "Imatinib and chronic myeloid leukemia" "rRNA modification in the nucleus and cytosol; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation" "3" "0" "0.933" "0.904" "0.885" "0.895" "0.819" "0.830" "0.866" "0.826" "0.491" "670.8" "625.6" "606.4" "593.8" "600.3" "549.1" "557.0" "581.1" "554.2" "329.2" "" "" "" "" "" "" "" "" "" "" "401.4" "325.1" "335.8" "278.8" "278.3" "281.1" "259.0" "260.9" "300.7" "329.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951583387108982266" "False" "High" "IsMasterProtein" "P11171" "Protein 4.1 OS=Homo sapiens OX=9606 GN=EPB41 PE=1 SV=4" "0.000" "False" "21.621" "10" "8" "9" "7" "864" "97.0" "5.58" "15.96" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" "2035" "ENSG00000159023" "EPB41" "B1ALH8; B1ALH9; D3DPM9; D3DPN0; hsa:2035; P11171; P11176; Q14245; Q5TB35; Q5VXN8; Q8IXV9; Q9Y578; Q9Y579" "VEGFA-VEGFR2 signaling; Splicing factor NOVA regulated synaptic proteins; IL-18 signaling pathway" "Neurexins and neuroligins" "4" "0" "1.140" "1.062" "1.027" "1.160" "1.126" "1.167" "1.135" "1.201" "2.077" "278.0" "316.9" "295.1" "285.5" "322.4" "312.9" "324.4" "315.6" "333.9" "577.3" "" "" "" "" "" "" "" "" "" "" "166.3" "164.7" "163.4" "134.0" "149.4" "160.2" "150.8" "141.7" "181.2" "577.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1361543221458196950" "False" "High" "IsMasterProtein" "O60547" "GDP-mannose 4,6 dehydratase OS=Homo sapiens OX=9606 GN=GMDS PE=1 SV=1" "0.000" "False" "21.619" "24" "9" "9" "9" "372" "41.9" "7.31" "21.83" "9" "other metabolic processes;signal transduction" "cytosol;other cell component" "other molecular function" "Pf16363" "2762" "ENSG00000112699" "GMDS" "E9PI88; hsa:2762; O60547; O75357; Q5T954; Q6FH09; Q9UGZ3; Q9UJK9" "" "GDP-fucose biosynthesis" "1" "0" "0.997" "0.917" "0.984" "1.193" "0.969" "1.087" "1.070" "0.969" "0.628" "460.8" "459.5" "422.7" "453.3" "549.5" "446.6" "500.8" "493.2" "446.7" "289.4" "" "" "" "" "" "" "" "" "" "" "275.8" "238.8" "234.1" "212.8" "254.7" "228.6" "232.8" "221.4" "242.3" "289.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5729262198654758902" "False" "High" "IsMasterProtein" "O43396" "Thioredoxin-like protein 1 OS=Homo sapiens OX=9606 GN=TXNL1 PE=1 SV=3" "0.000" "False" "21.605" "27" "6" "13" "6" "289" "32.2" "4.96" "29.18" "6" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf00085, Pf06201" "9352" "ENSG00000091164" "TXNL1" "hsa:9352; O43396" "" "RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "7" "0" "1.170" "1.390" "1.199" "1.144" "1.068" "1.150" "0.568" "1.032" "6.340" "244.9" "286.5" "340.3" "293.7" "280.2" "261.5" "281.5" "139.0" "252.6" "1552.3" "" "" "" "" "" "" "" "" "" "" "146.5" "148.9" "188.5" "137.9" "129.9" "133.9" "130.9" "62.4" "137.1" "1552.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1416539979039474058" "False" "High" "IsMasterProtein" "Q99426" "Tubulin-folding cofactor B OS=Homo sapiens OX=9606 GN=TBCB PE=1 SV=2" "0.000" "False" "21.541" "24" "5" "11" "5" "244" "27.3" "5.15" "30.36" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf01302, Pf14560" "1155" "ENSG00000105254" "TBCB" "hsa:1155; O00111; O00674; O14728; Q6FGY5; Q99426" "" "Post-chaperonin tubulin folding pathway" "1" "0" "1.048" "1.476" "1.171" "1.211" "1.005" "1.154" "0.934" "1.239" "4.510" "207.1" "217.1" "305.7" "242.6" "251.0" "208.3" "239.0" "193.5" "256.7" "934.3" "" "" "" "" "" "" "" "" "" "" "124.0" "112.8" "169.3" "113.9" "116.3" "106.6" "111.1" "86.9" "139.3" "934.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-597243898993742241" "False" "High" "IsMasterProtein" "P17096" "High mobility group protein HMG-I/HMG-Y OS=Homo sapiens OX=9606 GN=HMGA1 PE=1 SV=3" "0.000" "False" "21.521" "30" "3" "29" "3" "107" "11.7" "10.32" "82.08" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "" "3159" "ENSG00000137309" "HMGA1" "hsa:3159; P10910; P17096; Q5T6U9; Q9UKB0" "Adipogenesis; Pre-implantation embryo; Male infertility; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Orexin receptor pathway" "Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "13" "0" "1.053" "1.027" "0.988" "0.965" "1.022" "1.041" "1.163" "1.039" "0.448" "2336.5" "2461.2" "2400.1" "2309.1" "2255.1" "2388.8" "2432.1" "2718.0" "2427.5" "1047.7" "" "" "" "" "" "" "" "" "" "" "1398.3" "1279.0" "1329.1" "1084.1" "1045.3" "1222.9" "1130.9" "1220.2" "1317.0" "1047.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9136982351856623934" "False" "High" "IsMasterProtein" "P01861" "Immunoglobulin heavy constant gamma 4 OS=Homo sapiens OX=9606 GN=IGHG4 PE=1 SV=2" "0.000" "False" "21.505" "13" "4" "20" "4" "396" "43.8" "6.24" "60.14" "4" "stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf07654" "" "ENSG00000211892; ENSG00000277016" "IGHG4" "A0A286YFJ8; P01861" "" "Initial triggering of complement; Classical antibody-mediated complement activation; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of Complement cascade; Interleukin-4 and Interleukin-13 signaling" "9" "0" "0.912" "0.963" "1.026" "0.927" "0.921" "0.956" "0.893" "0.936" "0.986" "864.7" "788.5" "833.1" "887.1" "801.8" "796.6" "826.8" "772.2" "809.6" "852.6" "" "" "" "" "" "" "" "" "" "" "517.5" "409.7" "461.3" "416.5" "371.6" "407.8" "384.4" "346.7" "439.2" "852.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3119089922168410835" "False" "High" "IsMasterProtein" "P10606" "Cytochrome c oxidase subunit 5B, mitochondrial OS=Homo sapiens OX=9606 GN=COX5B PE=1 SV=2" "0.000" "False" "21.487" "40" "4" "11" "4" "129" "13.7" "8.81" "27.80" "4" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf01215" "1329" "ENSG00000135940; ENSG00000291596" "COX5B" "hsa:1329; P10606; Q53YB7; Q96J18; Q99610" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial protein degradation" "8" "0" "0.870" "0.995" "1.107" "1.082" "0.971" "1.064" "1.162" "1.014" "1.001" "334.9" "291.5" "333.1" "370.6" "362.3" "325.4" "356.2" "389.2" "339.4" "335.1" "" "" "" "" "" "" "" "" "" "" "200.4" "151.5" "184.5" "174.0" "167.9" "166.6" "165.6" "174.7" "184.2" "335.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3951454542439150493" "False" "High" "IsMasterProtein" "Q9HB40" "Retinoid-inducible serine carboxypeptidase OS=Homo sapiens OX=9606 GN=SCPEP1 PE=1 SV=1" "0.000" "False" "21.366" "11" "5" "6" "5" "452" "50.8" "5.81" "16.14" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00450" "59342" "ENSG00000121064" "SCPEP1" "hsa:59342; Q96A94; Q9H3F0; Q9HB40" "" "" "0" "0" "1.222" "1.045" "1.030" "1.128" "1.135" "1.145" "1.150" "1.171" "0.765" "476.2" "581.8" "497.5" "490.7" "537.2" "540.8" "545.2" "547.7" "557.6" "364.2" "" "" "" "" "" "" "" "" "" "" "285.0" "302.3" "275.5" "230.4" "249.0" "276.8" "253.5" "245.9" "302.5" "364.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6101901840121098087" "False" "High" "IsMasterProtein" "P52788" "Spermine synthase OS=Homo sapiens OX=9606 GN=SMS PE=1 SV=2" "0.000" "False" "21.360" "14" "6" "16" "6" "366" "41.2" "5.02" "34.79" "6" "other metabolic processes" "cytosol" "other molecular function" "Pf01564, Pf17284, Pf17950" "6611" "ENSG00000102172" "SMS" "A6NHA7; A6NI34; B2R9M0; hsa:6611; O00544; P52788; Q9UQS1" "Methionine de novo and salvage pathway; Amino acid metabolism" "Metabolism of polyamines" "3" "0" "0.987" "0.901" "0.923" "0.901" "0.894" "0.862" "0.947" "0.896" "0.615" "799.7" "789.5" "720.9" "737.8" "720.5" "714.6" "689.0" "757.7" "717.0" "491.8" "" "" "" "" "" "" "" "" "" "" "478.6" "410.3" "399.2" "346.4" "333.9" "365.8" "320.4" "340.1" "389.0" "491.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1734790582977372175" "False" "High" "IsMasterProtein" "P54136" "Arginine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=RARS1 PE=1 SV=2" "0.000" "False" "21.356" "9" "7" "7" "7" "660" "75.3" "6.68" "20.79" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00750, Pf03485, Pf05746" "5917" "ENSG00000113643" "RARS1" "B2RBS9; hsa:5917; P54136; Q53GY4; Q9BWA1" "Amino acid metabolism" "Cytosolic tRNA aminoacylation; Selenoamino acid metabolism" "3" "0" "1.152" "1.149" "1.393" "1.246" "1.190" "1.085" "0.326" "1.502" "10.856" "178.2" "205.3" "204.7" "248.2" "222.0" "212.0" "193.4" "58.0" "267.6" "1934.2" "" "" "" "" "" "" "" "" "" "" "106.6" "106.7" "113.4" "116.5" "102.9" "108.5" "89.9" "26.1" "145.2" "1934.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1852807762900550805" "False" "High" "IsMasterProtein" "P28070" "Proteasome subunit beta type-4 OS=Homo sapiens OX=9606 GN=PSMB4 PE=1 SV=4" "0.000" "False" "21.326" "16" "4" "24" "4" "264" "29.2" "5.97" "61.75" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00227" "5692" "ENSG00000159377" "PSMB4" "B2R9L3; hsa:5692; P28070; P31148; Q5SZS5; Q6IBI4; Q969L6" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "1.026" "1.488" "1.174" "1.110" "1.007" "1.097" "1.084" "1.118" "0.886" "911.8" "935.8" "1356.4" "1070.4" "1012.1" "918.0" "1000.1" "988.6" "1019.0" "807.5" "" "" "" "" "" "" "" "" "" "" "545.7" "486.3" "751.2" "502.5" "469.1" "470.0" "465.0" "443.8" "552.9" "807.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4634668291009869452" "False" "High" "IsMasterProtein" "Q9UNP9" "Peptidyl-prolyl cis-trans isomerase E OS=Homo sapiens OX=9606 GN=PPIE PE=1 SV=1" "0.000" "False" "21.313" "21" "6" "7" "5" "301" "33.4" "5.60" "15.25" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00160" "10450" "ENSG00000084072" "PPIE" "B2R971; hsa:10450; O43634; O43635; Q32Q72; Q3S611; Q5TGA0; Q5TGA2; Q5TGA3; Q9UIZ5; Q9UNP9" "" "Neutrophil degranulation; mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "6" "0" "1.030" "1.019" "1.061" "0.989" "0.931" "0.956" "1.018" "0.868" "0.679" "143.1" "147.4" "145.8" "151.9" "141.5" "133.2" "136.7" "145.7" "124.3" "97.1" "" "" "" "" "" "" "" "" "" "" "85.6" "76.6" "80.7" "71.3" "65.6" "68.2" "63.6" "65.4" "67.4" "97.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6313231503744566384" "False" "High" "IsMasterProtein" "O00754" "Lysosomal alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2B1 PE=1 SV=3" "0.000" "False" "21.306" "7" "7" "11" "7" "1011" "113.7" "7.28" "19.29" "7" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01074, Pf07748, Pf09261, Pf21260" "4125" "ENSG00000104774" "MAN2B1" "G5E928; hsa:4125; O00754; O15330; Q16680; Q93094; Q9BW13" "" "Neutrophil degranulation; Lysosomal oligosaccharide catabolism" "2" "0" "0.931" "0.881" "1.002" "1.029" "0.959" "1.036" "0.881" "1.096" "0.733" "415.1" "386.2" "365.6" "415.8" "426.9" "398.2" "430.2" "365.6" "454.9" "304.1" "" "" "" "" "" "" "" "" "" "" "248.4" "200.7" "202.5" "195.2" "197.9" "203.9" "200.0" "164.1" "246.8" "304.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4087674429968217888" "False" "High" "IsMasterProtein" "P63010" "AP-2 complex subunit beta OS=Homo sapiens OX=9606 GN=AP2B1 PE=1 SV=1" "0.000" "False" "21.227" "6" "7" "11" "1" "937" "104.5" "5.38" "31.64" "7" "transport;developmental processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02883, Pf09066" "163" "ENSG00000006125" "AP2B1" "A6NJP3; hsa:163; P21851; P63010; Q7Z451; Q96J19" "Synaptic vesicle pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission; Markers of kidney cell lineage; 17q12 copy number variation syndrome" "MHC class II antigen presentation; Potential therapeutics for SARS; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "20" "0" "0.866" "0.914" "0.899" "1.002" "1.030" "0.979" "1.265" "1.066" "1.444" "85.2" "73.8" "77.9" "76.6" "85.4" "87.8" "83.4" "107.8" "90.8" "123.1" "" "" "" "" "" "" "" "" "" "" "51.0" "38.4" "43.1" "36.0" "39.6" "44.9" "38.8" "48.4" "49.3" "123.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7964397888877464485" "False" "High" "IsMasterProtein" "P50897" "Palmitoyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=PPT1 PE=1 SV=1" "0.000" "False" "21.193" "22" "5" "6" "5" "306" "34.2" "6.52" "19.90" "5" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02089" "5538" "ENSG00000131238" "PPT1" "B4DY24; hsa:5538; P50897; Q6FGQ4" "" "Fatty acyl-CoA biosynthesis" "1" "0" "1.038" "1.168" "0.834" "0.913" "1.189" "0.767" "1.110" "1.232" "0.686" "195.3" "202.8" "228.1" "162.9" "178.3" "232.2" "149.8" "216.8" "240.6" "133.9" "" "" "" "" "" "" "" "" "" "" "116.9" "105.4" "126.3" "76.5" "82.7" "118.9" "69.7" "97.3" "130.5" "133.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3175822401937946454" "False" "High" "IsMasterProtein" "Q15942" "Zyxin OS=Homo sapiens OX=9606 GN=ZYX PE=1 SV=1" "0.000" "False" "21.187" "12" "6" "9" "6" "572" "61.2" "6.67" "26.57" "6" "cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "7791" "ENSG00000159840; ENSG00000285443" "ZYX" "A4D2G6; B4DQX7; hsa:7791; Q15942; Q6I9S4" "Integrin-mediated cell adhesion; Focal adhesion" "" "2" "0" "1.143" "1.091" "1.072" "0.975" "0.895" "1.039" "1.091" "1.008" "0.493" "1143.7" "1307.0" "1247.6" "1226.1" "1114.7" "1023.5" "1187.9" "1247.4" "1152.7" "563.8" "" "" "" "" "" "" "" "" "" "" "684.4" "679.2" "690.9" "575.6" "516.7" "523.9" "552.4" "560.0" "625.4" "563.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4576818443980197018" "False" "High" "IsMasterProtein" "P52292" "Importin subunit alpha-1 OS=Homo sapiens OX=9606 GN=KPNA2 PE=1 SV=1" "0.000" "False" "21.109" "9" "4" "7" "4" "529" "57.8" "5.40" "19.66" "4" "DNA metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3838" "ENSG00000182481" "KPNA2" "B9EJD6; hsa:3838; P52292; Q53YE3; Q6NVW7; Q9BRU5" "" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Estrogen-dependent gene expression; SARS-CoV-1 activates/modulates innate immune responses; Sensing of DNA Double Strand Breaks; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde" "8" "0" "0.975" "1.058" "1.041" "1.166" "1.302" "0.944" "0.413" "1.098" "5.830" "56.4" "55.0" "59.7" "58.8" "65.8" "73.5" "53.3" "23.3" "62.0" "329.0" "" "" "" "" "" "" "" "" "" "" "33.8" "28.6" "33.1" "27.6" "30.5" "37.6" "24.8" "10.5" "33.6" "329.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4838480320139969571" "False" "High" "IsMasterProtein" "Q13951" "Core-binding factor subunit beta OS=Homo sapiens OX=9606 GN=CBFB PE=1 SV=2" "0.000" "False" "21.103" "26" "5" "10" "5" "182" "21.5" "6.60" "29.97" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02312" "865" "ENSG00000067955" "CBFB" "A8K347; hsa:865; Q13124; Q13951; Q9HCT2" "Dual hijack model of Vif in HIV infection; Hijack of ubiquitination by SARS-CoV-2" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of RUNX3 expression and activity; RUNX2 regulates osteoblast differentiation; Estrogen-dependent gene expression; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RUNX1 regulates expression of components of tight junctions; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; RUNX1 regulates estrogen receptor mediated transcription; RUNX1 regulates transcription of genes involved in WNT signaling; Transcriptional regulation of granulopoiesis; RUNX2 regulates genes involved in cell migration; RUNX3 regulates p14-ARF; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs); RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX2 regulates chondrocyte maturation; RUNX3 Regulates Immune Response and Cell Migration; Regulation of RUNX1 Expression and Activity; RUNX2 regulates genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in BCR signaling; RUNX3 regulates RUNX1-mediated transcription" "27" "0" "1.041" "1.098" "1.010" "1.113" "0.918" "1.162" "0.987" "1.079" "2.402" "291.7" "303.6" "320.2" "294.8" "324.7" "267.7" "339.1" "287.9" "314.8" "700.9" "" "" "" "" "" "" "" "" "" "" "174.6" "157.8" "177.3" "138.4" "150.5" "137.1" "157.7" "129.2" "170.8" "700.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8881976693439910842" "False" "High" "IsMasterProtein" "P40306" "Proteasome subunit beta type-10 OS=Homo sapiens OX=9606 GN=PSMB10 PE=1 SV=1" "0.000" "False" "21.082" "19" "5" "7" "5" "273" "28.9" "7.81" "20.99" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf12465" "5699" "ENSG00000205220" "PSMB10" "B2R5J4; hsa:5699; P40306; Q5U098" "Proteasome degradation" "Degradation of beta-catenin by the destruction complex; Separation of Sister Chromatids; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "60" "0" "0.897" "0.986" "1.077" "0.967" "0.955" "1.037" "1.113" "1.091" "0.695" "764.8" "686.0" "754.3" "823.9" "739.7" "730.6" "793.4" "851.4" "834.6" "531.4" "" "" "" "" "" "" "" "" "" "" "457.7" "356.5" "417.7" "386.8" "342.9" "374.0" "368.9" "382.2" "452.8" "531.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1619484696952214884" "False" "High" "IsMasterProtein" "P24534" "Elongation factor 1-beta OS=Homo sapiens OX=9606 GN=EEF1B2 PE=1 SV=3" "0.000" "False" "21.081" "23" "5" "11" "5" "225" "24.7" "4.67" "29.43" "5" "protein metabolism;other metabolic processes" "cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf00736, Pf10587" "1933" "ENSG00000114942; ENSG00000283391" "EEF1B2" "A8K795; hsa:1933; P24534; Q6IBH9" "Translation factors" "Eukaryotic Translation Elongation" "2" "0" "0.964" "1.137" "0.965" "1.045" "0.917" "0.943" "0.546" "1.085" "6.385" "308.5" "297.3" "350.8" "297.6" "322.4" "282.9" "290.8" "168.5" "334.8" "1969.9" "" "" "" "" "" "" "" "" "" "" "184.6" "154.5" "194.3" "139.7" "149.4" "144.8" "135.2" "75.6" "181.7" "1969.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5150422290065042412" "False" "High" "IsMasterProtein" "Q9BXL5" "Hemogen OS=Homo sapiens OX=9606 GN=HEMGN PE=1 SV=1" "0.000" "False" "21.054" "16" "7" "10" "7" "484" "55.3" "4.87" "16.49" "7" "other biological processes" "nucleus" "" "" "55363" "ENSG00000136929" "HEMGN" "hsa:55363; Q6XAR3; Q86XY5; Q9BXL5; Q9NPC0" "" "" "0" "0" "0.963" "0.935" "1.013" "1.003" "0.929" "0.886" "1.062" "0.981" "0.570" "265.4" "255.5" "248.2" "268.9" "266.2" "246.4" "235.2" "281.8" "260.3" "151.3" "" "" "" "" "" "" "" "" "" "" "158.8" "132.8" "137.5" "126.2" "123.4" "126.2" "109.4" "126.5" "141.2" "151.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4905591351439676835" "False" "High" "IsMasterProtein" "P50995" "Annexin A11 OS=Homo sapiens OX=9606 GN=ANXA11 PE=1 SV=1" "0.000" "False" "21.032" "12" "6" "8" "6" "505" "54.4" "7.65" "16.49" "6" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00191" "311" "ENSG00000122359" "ANXA11" "B4DVE7; hsa:311; P50995" "" "" "0" "0" "0.903" "0.966" "1.247" "1.035" "1.237" "1.160" "0.471" "1.227" "8.358" "42.9" "38.7" "41.4" "53.5" "44.4" "53.0" "49.7" "20.2" "52.6" "358.3" "" "" "" "" "" "" "" "" "" "" "25.7" "20.1" "22.9" "25.1" "20.6" "27.1" "23.1" "9.1" "28.5" "358.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8586713697824146806" "False" "High" "IsMasterProtein" "P46379" "Large proline-rich protein BAG6 OS=Homo sapiens OX=9606 GN=BAG6 PE=1 SV=2" "0.000" "False" "21.007" "8" "7" "8" "7" "1132" "119.3" "5.60" "18.21" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;translation activity;other molecular function" "Pf00240, Pf12057, Pf20960" "7917" "ENSG00000096155; ENSG00000204463; ENSG00000227761; ENSG00000228760; ENSG00000229524; ENSG00000233348; ENSG00000234651" "BAG6" "A2ADJ7; A3KQ42; A3KQ44; A6NGY6; A6PWF7; B0UX84; B4DZ12; B4E3V4; E7EMZ4; F8VXY4; hsa:7917; O95874; P46379; Q5HYL9; Q5SQ35; Q5SQ36; Q5SQ37; Q5SQ41; Q5SRP8; Q5SRP9; Q5STC1; Q5STX1; Q5STX3; Q96SA6; Q9BCN4" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "1.024" "1.024" "1.035" "1.106" "1.069" "1.150" "1.060" "1.080" "1.474" "217.4" "222.7" "222.6" "224.9" "240.5" "232.4" "250.1" "230.5" "234.9" "320.6" "" "" "" "" "" "" "" "" "" "" "130.1" "115.7" "123.3" "105.6" "111.5" "119.0" "116.3" "103.5" "127.4" "320.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9010932242184779008" "False" "High" "IsMasterProtein" "P10644" "cAMP-dependent protein kinase type I-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR1A PE=1 SV=1" "0.000" "False" "21.006" "13" "6" "7" "5" "381" "43.0" "5.35" "21.14" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5573" "ENSG00000108946" "PRKAR1A" "hsa:5573; K7ER48; P10644; Q567S7" "Mesodermal commitment pathway; Myometrial relaxation and contraction pathways; Mesodermal commitment pathway; G protein signaling pathways; Cannabinoid receptor signaling; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Cardiomyocyte signaling pathways converging on titin; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase" "27" "0" "1.243" "1.125" "1.149" "1.159" "1.136" "1.102" "0.975" "1.332" "4.103" "153.4" "190.6" "172.5" "176.2" "177.8" "174.2" "169.0" "149.5" "204.3" "629.4" "" "" "" "" "" "" "" "" "" "" "91.8" "99.0" "95.6" "82.7" "82.4" "89.2" "78.6" "67.1" "110.8" "629.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6282846472165231546" "False" "High" "IsMasterProtein" "Q9P289" "Serine/threonine-protein kinase 26 OS=Homo sapiens OX=9606 GN=STK26 PE=1 SV=2" "0.000" "False" "20.893" "15" "7" "9" "2" "416" "46.5" "5.29" "22.54" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "51765" "ENSG00000134602" "STK26" "B2RAU2; hsa:51765; Q3ZB77; Q8NC04; Q9BXC3; Q9BXC4; Q9P289" "" "Apoptotic cleavage of cellular proteins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7310593134022698633" "False" "High" "IsMasterProtein" "P57081" "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 OS=Homo sapiens OX=9606 GN=WDR4 PE=1 SV=2" "0.000" "False" "20.832" "15" "5" "9" "5" "412" "45.5" "7.11" "29.49" "5" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf00400" "10785" "ENSG00000160193" "WDR4" "A8KA58; B2RCA3; B4DNQ7; D3DSK3; hsa:10785; P57081; Q9BVM5; Q9HCR3" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.971" "1.006" "1.005" "0.917" "1.020" "0.895" "0.940" "0.911" "0.869" "719.5" "698.8" "723.8" "723.2" "659.6" "733.8" "644.0" "676.4" "655.3" "624.9" "" "" "" "" "" "" "" "" "" "" "430.6" "363.1" "400.8" "339.5" "305.7" "375.7" "299.4" "303.7" "355.5" "624.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3588526575422441763" "False" "High" "IsMasterProtein" "P42285" "Exosome RNA helicase MTR4 OS=Homo sapiens OX=9606 GN=MTREX PE=1 SV=3" "0.000" "False" "20.774" "6" "7" "7" "7" "1042" "117.7" "6.52" "15.14" "7" "RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf08148, Pf13234, Pf21408" "23517" "ENSG00000039123" "MTREX" "hsa:23517; P42285; Q2M386; Q6MZZ8; Q6P170; Q8N5R0; Q8TAG2" "" "mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol" "2" "0" "1.012" "1.076" "1.076" "1.237" "1.219" "1.090" "1.066" "1.029" "3.150" "266.6" "269.8" "286.8" "286.9" "329.9" "324.9" "290.6" "284.2" "274.5" "839.7" "" "" "" "" "" "" "" "" "" "" "159.5" "140.2" "158.8" "134.7" "152.9" "166.3" "135.1" "127.6" "148.9" "839.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3913128170310311305" "False" "High" "IsMasterProtein" "O00487" "26S proteasome non-ATPase regulatory subunit 14 OS=Homo sapiens OX=9606 GN=PSMD14 PE=1 SV=1" "0.000" "False" "20.769" "21" "7" "16" "7" "310" "34.6" "6.52" "45.43" "7" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01398" "10213" "ENSG00000115233" "PSMD14" "B3KNW2; hsa:10213; O00176; O00487" "Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Metalloprotease DUBs" "64" "0" "1.049" "0.963" "1.029" "1.009" "1.048" "0.975" "1.057" "0.927" "0.721" "1927.2" "2021.1" "1855.8" "1983.9" "1943.6" "2019.5" "1879.0" "2037.7" "1786.9" "1388.6" "" "" "" "" "" "" "" "" "" "" "1153.3" "1050.3" "1027.7" "931.4" "900.9" "1033.8" "873.7" "914.8" "969.5" "1388.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1679721907195940966" "False" "High" "IsMasterProtein" "P50502" "Hsc70-interacting protein OS=Homo sapiens OX=9606 GN=ST13 PE=1 SV=2" "0.000" "False" "20.762" "14" "5" "10" "5" "369" "41.3" "5.27" "26.69" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf17830, Pf18253" "6767" "ENSG00000100380" "ST13" "hsa:6767; O14999; P50502; Q2TU77" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "1.095" "1.307" "0.961" "1.201" "1.080" "1.170" "0.866" "1.113" "3.546" "430.8" "471.5" "562.9" "413.9" "517.5" "465.3" "503.9" "372.9" "479.6" "1527.5" "" "" "" "" "" "" "" "" "" "" "257.8" "245.0" "311.7" "194.3" "239.9" "238.2" "234.3" "167.4" "260.2" "1527.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5301300435928167882" "False" "High" "IsMasterProtein" "P47755" "F-actin-capping protein subunit alpha-2 OS=Homo sapiens OX=9606 GN=CAPZA2 PE=1 SV=3" "0.000" "False" "20.646" "23" "5" "19" "4" "286" "32.9" "5.85" "50.16" "5" "cell organization and biogenesis" "non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01267" "830" "ENSG00000198898" "CAPZA2" "B4DG50; hsa:830; P47755" "" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Sensory processing of sound by inner hair cells of the cochlea; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling" "7" "0" "1.176" "1.261" "1.114" "1.323" "1.419" "1.246" "1.173" "1.259" "1.595" "87.6" "103.1" "110.5" "97.6" "115.9" "124.4" "109.2" "102.8" "110.3" "139.8" "" "" "" "" "" "" "" "" "" "" "52.4" "53.6" "61.2" "45.8" "53.7" "63.7" "50.8" "46.1" "59.9" "139.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3912553749902594293" "False" "High" "IsMasterProtein" "P15880" "Small ribosomal subunit protein uS5 OS=Homo sapiens OX=9606 GN=RPS2 PE=1 SV=2" "0.000" "False" "20.582" "22" "7" "8" "7" "293" "31.3" "10.24" "21.83" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00333, Pf03719" "6187" "ENSG00000140988; ENSG00000291931" "RPS2" "B2R5G0; D3DU82; hsa:6187; P15880; Q3MIB1" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Protein methylation; Peptide chain elongation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; RMTs methylate histone arginines; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "22" "0" "0.920" "0.970" "0.878" "0.948" "1.011" "0.986" "0.761" "0.998" "3.135" "381.0" "350.6" "369.6" "334.4" "361.1" "385.0" "375.5" "289.8" "380.3" "1194.2" "" "" "" "" "" "" "" "" "" "" "228.0" "182.2" "204.7" "157.0" "167.4" "197.1" "174.6" "130.1" "206.3" "1194.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4729149100999833326" "False" "High" "IsMasterProtein" "Q9NT62" "Ubiquitin-like-conjugating enzyme ATG3 OS=Homo sapiens OX=9606 GN=ATG3 PE=1 SV=1" "0.000" "False" "20.578" "15" "4" "8" "4" "314" "35.8" "4.74" "15.91" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf03987" "64422" "ENSG00000144848" "ATG3" "hsa:64422; Q6PKC5; Q9H6L9; Q9NT62" "Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "6" "0" "1.036" "0.944" "1.074" "0.948" "1.054" "1.101" "1.026" "1.039" "0.871" "214.0" "221.7" "202.0" "229.9" "202.9" "225.5" "235.7" "219.6" "222.3" "186.4" "" "" "" "" "" "" "" "" "" "" "128.1" "115.2" "111.9" "107.9" "94.0" "115.4" "109.6" "98.6" "120.6" "186.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4100918330742864628" "False" "High" "IsMasterProtein" "Q96GK7" "Oxaloacetate tautomerase FAHD2A, mitochondrial OS=Homo sapiens OX=9606 GN=FAHD2A PE=1 SV=1" "0.000" "False" "20.559" "18" "5" "14" "5" "314" "34.6" "8.24" "39.60" "5" "" "" "other molecular function" "Pf01557" "51011" "ENSG00000115042; ENSG00000292086" "FAHD2A" "hsa:51011; Q96GK7; Q9Y3B0" "" "" "0" "0" "1.014" "0.978" "0.977" "1.041" "0.989" "1.055" "0.970" "1.031" "0.702" "867.6" "880.0" "848.1" "848.0" "903.0" "857.8" "915.2" "841.7" "894.5" "608.9" "" "" "" "" "" "" "" "" "" "" "519.2" "457.3" "469.7" "398.1" "418.6" "439.1" "425.5" "377.9" "485.3" "608.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6687870354662644574" "False" "High" "IsMasterProtein" "Q8N3D4" "EH domain-binding protein 1-like protein 1 OS=Homo sapiens OX=9606 GN=EHBP1L1 PE=1 SV=2" "0.000" "False" "20.550" "5" "6" "6" "6" "1523" "161.8" "4.83" "10.93" "6" "" "other cytoplasmic organelle" "" "Pf00307, Pf10358, Pf12130" "254102" "ENSG00000173442" "EHBP1L1" "hsa:254102; Q8N3D4; Q8TB89; Q9H7M7" "" "" "0" "0" "1.056" "1.079" "1.001" "0.954" "1.151" "1.134" "1.109" "1.144" "0.846" "108.0" "114.0" "116.5" "108.0" "103.0" "124.3" "122.4" "119.7" "123.5" "91.4" "" "" "" "" "" "" "" "" "" "" "64.6" "59.2" "64.5" "50.7" "47.8" "63.6" "56.9" "53.7" "67.0" "91.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9040349963704556613" "False" "High" "IsMasterProtein" "P30154" "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform OS=Homo sapiens OX=9606 GN=PPP2R1B PE=1 SV=3" "0.000" "False" "20.545" "9" "6" "8" "3" "601" "66.2" "4.94" "18.32" "6" "other biological processes" "other membranes;other cell component" "enzyme regulator activity" "Pf02985, Pf13646" "5519" "ENSG00000137713" "PPP2R1B" "A8MY67; B0YJ69; B4DGQ6; B4DK91; B4DWW5; F8W8G1; hsa:5519; O75620; P30154; Q8NHV8" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Netrin-UNC5B signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; DARPP-32 events; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; PKR-mediated signaling; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "40" "0" "1.276" "1.524" "1.563" "1.732" "2.340" "1.151" "0.073" "1.261" "11.588" "13.8" "17.7" "21.1" "21.6" "24.0" "32.4" "15.9" "1.0" "17.5" "160.5" "" "" "" "" "" "" "" "" "" "" "8.3" "9.2" "11.7" "10.2" "11.1" "16.6" "7.4" "0.5" "9.5" "160.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1214418954468839603" "False" "High" "IsMasterProtein" "Q96C01" "Protein FAM136A OS=Homo sapiens OX=9606 GN=FAM136A PE=1 SV=1" "0.000" "False" "20.489" "41" "6" "11" "6" "138" "15.6" "7.61" "27.87" "6" "" "other cell component" "" "Pf05811" "84908" "ENSG00000035141" "FAM136A" "hsa:84908; Q96C01; Q96SS3" "" "" "0" "0" "0.970" "0.972" "0.931" "1.053" "0.960" "1.044" "1.036" "0.944" "1.011" "489.3" "474.8" "475.4" "455.4" "515.2" "469.9" "511.0" "507.0" "462.0" "494.8" "" "" "" "" "" "" "" "" "" "" "292.8" "246.8" "263.3" "213.8" "238.8" "240.5" "237.6" "227.6" "250.7" "494.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4636367879172640363" "False" "High" "IsMasterProtein" "P24666" "Low molecular weight phosphotyrosine protein phosphatase OS=Homo sapiens OX=9606 GN=ACP1 PE=1 SV=3" "0.000" "False" "20.472" "24" "3" "9" "3" "158" "18.0" "6.74" "26.31" "3" "" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01451" "52" "ENSG00000143727" "ACP1" "A8K1L9; B5MCC7; hsa:52; P24666; P24667; Q16035; Q16036; Q16725; Q3KQX8; Q53RU0" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.913" "1.123" "1.132" "1.089" "1.065" "0.933" "0.888" "0.989" "3.164" "297.0" "271.0" "333.6" "336.3" "323.3" "316.2" "277.2" "263.7" "293.6" "939.6" "" "" "" "" "" "" "" "" "" "" "177.7" "140.8" "184.7" "157.9" "149.9" "161.9" "128.9" "118.4" "159.3" "939.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "222321955828462706" "False" "High" "IsMasterProtein" "O00244" "Copper transport protein ATOX1 OS=Homo sapiens OX=9606 GN=ATOX1 PE=1 SV=1" "0.000" "False" "20.463" "75" "4" "16" "4" "68" "7.4" "7.24" "46.82" "4" "stress response;transport;other biological processes" "cytosol" "other molecular function" "Pf00403" "475" "ENSG00000177556" "ATOX1" "A8KAJ8; D3DQI2; hsa:475; O00244; Q2M1R6; Q56AP3" "Copper homeostasis" "Detoxification of Reactive Oxygen Species; Ion influx/efflux at host-pathogen interface" "3" "0" "1.092" "0.939" "0.969" "1.025" "1.020" "1.059" "1.087" "1.116" "0.534" "227.5" "248.5" "213.6" "220.4" "233.2" "232.0" "241.0" "247.2" "253.9" "121.4" "" "" "" "" "" "" "" "" "" "" "136.2" "129.1" "118.3" "103.5" "108.1" "118.8" "112.1" "111.0" "137.8" "121.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4994086141420822230" "False" "High" "IsMasterProtein" "P02794" "Ferritin heavy chain OS=Homo sapiens OX=9606 GN=FTH1 PE=1 SV=2" "0.000" "False" "20.403" "33" "6" "15" "6" "183" "21.2" "5.55" "40.89" "6" "transport;other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00210" "2495" "ENSG00000167996" "FTH1" "B3KNR5; hsa:2495; P02794; Q3KRA8; Q3SWW1" "Iron metabolism in placenta; Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Iron metabolism disorders" "Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Iron uptake and transport; Scavenging by Class A Receptors" "9" "0" "1.013" "0.928" "0.996" "0.954" "0.904" "1.100" "1.046" "0.942" "0.555" "561.0" "568.1" "520.4" "558.6" "535.4" "506.9" "617.2" "586.7" "528.3" "311.5" "" "" "" "" "" "" "" "" "" "" "335.7" "295.2" "288.2" "262.2" "248.2" "259.5" "287.0" "263.4" "286.6" "311.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2558659697255910600" "False" "High" "IsMasterProtein" "Q92747" "Actin-related protein 2/3 complex subunit 1A OS=Homo sapiens OX=9606 GN=ARPC1A PE=1 SV=2" "0.000" "False" "20.348" "16" "6" "9" "6" "370" "41.5" "8.18" "26.42" "6" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00400" "10552" "ENSG00000241685" "ARPC1A" "A4D276; B4DLQ7; D6W5S1; hsa:10552; Q7Z5U8; Q86WU5; Q8IXQ0; Q92747" "Pathogenic Escherichia coli infection" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Clathrin-mediated endocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling" "6" "0" "0.994" "1.010" "1.018" "0.927" "0.970" "0.975" "1.064" "0.978" "0.657" "541.3" "537.9" "546.6" "550.9" "501.6" "525.0" "527.9" "576.0" "529.4" "355.8" "" "" "" "" "" "" "" "" "" "" "323.9" "279.5" "302.7" "258.6" "232.5" "268.8" "245.5" "258.6" "287.2" "355.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3764850706603646464" "False" "High" "IsMasterProtein" "Q9ULC4" "Malignant T-cell-amplified sequence 1 OS=Homo sapiens OX=9606 GN=MCTS1 PE=1 SV=1" "0.000" "False" "20.284" "34" "5" "15" "5" "181" "20.5" "8.82" "41.20" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other cell component" "nucleic acid binding activity" "Pf01472, Pf17832" "28985" "ENSG00000232119" "MCTS1" "B4DGY2; hsa:28985; Q502X6; Q9ULC4" "" "" "0" "0" "0.976" "0.990" "0.948" "0.969" "1.045" "0.950" "1.040" "1.035" "0.655" "612.8" "597.8" "606.6" "581.0" "593.5" "640.6" "582.4" "637.3" "634.1" "401.3" "" "" "" "" "" "" "" "" "" "" "366.7" "310.7" "335.9" "272.8" "275.1" "327.9" "270.8" "286.1" "344.0" "401.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-579275288277334412" "False" "High" "IsMasterProtein" "P46736" "Lys-63-specific deubiquitinase BRCC36 OS=Homo sapiens OX=9606 GN=BRCC3 PE=1 SV=2" "0.000" "False" "20.282" "20" "5" "9" "5" "316" "36.0" "5.92" "19.73" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01398, Pf18110" "79184" "ENSG00000185515" "BRCC3" "A6QRF8; A6QRF9; A8MUX5; A8MWH0; A9Z1Y0; A9Z1Y5; B1B062; B4DQN7; hsa:79184; P46736; Q16107; Q53YX5; Q9BTZ6" "5q35 copy number variation" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs" "6" "0" "0.865" "0.993" "0.843" "0.901" "0.909" "0.836" "0.900" "0.950" "0.615" "109.6" "94.7" "108.8" "92.4" "98.8" "99.6" "91.6" "98.6" "104.1" "67.4" "" "" "" "" "" "" "" "" "" "" "65.6" "49.2" "60.3" "43.4" "45.8" "51.0" "42.6" "44.3" "56.5" "67.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7018160903413407228" "False" "High" "IsMasterProtein" "Q9BW85" "Splicing factor YJU2 OS=Homo sapiens OX=9606 GN=YJU2 PE=1 SV=1" "0.000" "False" "20.271" "15" "5" "8" "5" "323" "37.1" "5.92" "23.05" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf04502" "55702" "ENSG00000105248" "YJU2" "hsa:55702; O75270; Q9BW85; Q9H862; Q9NW16" "" "mRNA Splicing - Major Pathway" "1" "0" "1.092" "1.094" "0.952" "1.091" "1.165" "0.975" "1.070" "1.188" "1.037" "202.3" "221.0" "221.4" "192.6" "220.7" "235.7" "197.2" "216.5" "240.2" "209.8" "" "" "" "" "" "" "" "" "" "" "121.1" "114.8" "122.6" "90.4" "102.3" "120.7" "91.7" "97.2" "130.3" "209.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4567547795878987385" "False" "High" "IsMasterProtein" "P21333" "Filamin-A OS=Homo sapiens OX=9606 GN=FLNA PE=1 SV=4" "0.000" "False" "20.267" "2" "6" "7" "5" "2647" "280.6" "6.06" "18.73" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00630" "2316" "ENSG00000196924" "FLNA" "E9KL45; hsa:2316; P21333; Q5HY53; Q5HY55; Q8NF52" "Androgen receptor signaling pathway; Prolactin signaling pathway; Focal adhesion; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; IL-4 signaling pathway; Ebola virus infection in host; Joubert syndrome; NPHP1 deletion syndrome" "OAS antiviral response; Platelet degranulation ; RHO GTPases activate PAKs; GP1b-IX-V activation signalling; Cell-extracellular matrix interactions" "14" "0" "1.251" "1.360" "1.251" "1.248" "1.185" "1.300" "0.941" "1.238" "3.098" "107.2" "134.2" "145.9" "134.2" "133.9" "127.1" "139.5" "100.9" "132.8" "332.2" "" "" "" "" "" "" "" "" "" "" "64.2" "69.7" "80.8" "63.0" "62.1" "65.0" "64.8" "45.3" "72.0" "332.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2244898098371361519" "False" "High" "IsMasterProtein" "Q86VS8" "Protein Hook homolog 3 OS=Homo sapiens OX=9606 GN=HOOK3 PE=1 SV=2" "0.000" "False" "20.250" "11" "7" "8" "7" "718" "83.1" "5.17" "16.15" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf05622, Pf19047" "84376" "ENSG00000168172" "HOOK3" "D3DSY8; hsa:84376; Q86VS8; Q8NBH0; Q9BY13" "" "" "0" "0" "0.974" "0.891" "1.645" "1.077" "0.741" "1.492" "1.043" "0.890" "1.279" "225.7" "219.9" "201.2" "371.4" "243.2" "167.4" "336.7" "235.3" "200.9" "288.7" "" "" "" "" "" "" "" "" "" "" "135.1" "114.3" "111.4" "174.4" "112.7" "85.7" "156.6" "105.7" "109.0" "288.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4440624783436864340" "False" "High" "IsMasterProtein" "P01911" "HLA class II histocompatibility antigen, DRB1 beta chain OS=Homo sapiens OX=9606 GN=HLA-DRB1 PE=1 SV=2" "0.000" "False" "20.245" "23" "6" "11" "3" "266" "29.9" "7.74" "31.84" "6" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00969, Pf07654" "3123" "ENSG00000196126" "HLA-DRB1" "A0MWF2; A0N0W1; A2ICT1; A2TGX3; A4F5N0; A4ZXA5; A4ZXA6; A4ZY86; A5H000; A5HKN8; A7DZP9; A7LA26; A7UHG2; A7X5B1; A7X5B7; A7X5E0; A7X5E6; A7X5H8; A7X5J4; A7X5K7; A8K098; A8YQE9; A9JPG0; B0BK85; B0LUZ6; B0UYW1; B1GWE7; B2CR03; B2LVF9; B2NJ29; B2ZCY1; B3VTP8; B3VTQ3; B5A8Y2; B5A8Y3; B5B8U0; B5B9V5; B5B9V6; B5LZ25; B5QSK8; B6VCX2; B6VEL9; B7UDB2; B9VRA4; B9X248; C0LAB5; hsa:3123; O02876; O02930; O19585; O19717; O19718; O19739; O19788; O46699; O46793; O46872; O62869; O62889; O77969; O78047; O78210; O98212; P01911; P01912; P01914; P04229; P13758; P13759; P13760; P13761; P20039; P79545; Q06662; Q0PGR5; Q0PQ39; Q14280; Q14QT2; Q155F7; Q19AF2; Q19K86; Q1AP33; Q1G0Z9; Q1JRP3; Q1KLJ6; Q27PR6; Q27PR7; Q29673; Q29720; Q29722; Q29734; Q29770; Q29771; Q29772; Q29790; Q29792; Q29800; Q29806; Q29833; Q29874; Q29875; Q29886; Q29968; Q29974; Q29975; Q2A120; Q2HZE5; Q2L9H4; Q2LE76; Q2MF40; Q2MJA6; Q2MZ92; Q2VQU1; Q2YHQ2; Q30006; Q30108; Q30112; Q30115; Q30116; Q30117; Q30120; Q30134; Q30142; Q30145; Q30149; Q30159; Q30166; Q30167; Q30200; Q307W5; Q31636; Q32MY7; Q3HUP9; Q3KTM1; Q3LA84; Q3LA87; Q3LA88; Q3LA89; Q3LA90; Q3LA91; Q3LA92; Q3LA93; Q3LA94; Q3LA95; Q3LA96; Q3LA97; Q3LA98; Q3LA99; Q3LAA0; Q3LAA1; Q3LAA2; Q3MQ60; Q3T919; Q4PRC3; Q4PRC5; Q4VZY7; Q53IG1; Q56FN9; Q56FP1; Q56FP2; Q56FP3; Q58F52; Q5BM92; Q5EER6; Q5K3W2; Q5NDB9; Q5U9W6; Q5UBA2; Q5UT58; Q5W3L4; Q5Y7A7; Q5Y7B0; Q5Y7B9; Q5Y7E9; Q5Y7G0; Q683P7; Q6REE2; Q6T865; Q6U387; Q701T1; Q70GL2; Q70Q85; Q768U2; Q768U4; Q7M2H4; Q7YNY9; Q7YP03; Q7YP04; Q7YQ26; Q7YQA3; Q7YQA5; Q860D8; Q860D9; Q860E5; Q860H8; Q860S0; Q860Z3; Q861G6; Q861H0; Q861H4; Q861H5; Q861H7; Q861H8; Q8HWQ6; Q8MH59; Q8MH60; Q8WLU3; Q8WMA0; Q95348; Q95383; Q95389; Q95461; Q95HK1; Q95HL0; Q95HL1; Q95IE3; Q95IG2; Q95IT6; Q96HZ9; Q9BCL7; Q9BCP0; Q9BCP1; Q9BCP2; Q9BCP5; Q9BD21; Q9BD33; Q9BD40; Q9GIK5; Q9GIL5; Q9GIL6; Q9GIP3; Q9GIX8; Q9GIX9; Q9GIY0; Q9GIY1; Q9GIY2; Q9GIY3; Q9GIY4; Q9GJ25; Q9GJ56; Q9GJ57; Q9GJ58; Q9GJ60; Q9GJF8; Q9GJF9; Q9GJG0; Q9MXZ0; Q9MXZ5; Q9MY13; Q9MY45; Q9MY56; Q9MYF5; Q9TPB6; Q9TPW1; Q9TPW3; Q9TPW9; Q9TPX4; Q9TQ37; Q9TQ91; Q9TQE0; Q9UBY1; Q9UIM9; Q9UIN0; Q9XRX1; Q9XRY4; Q9XRY5; Q9Y453; Q9Y4H7" "Allograft rejection; Vitamin D receptor pathway; Ebola virus infection in host; Cancer immunotherapy by PD-1 blockade; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Genes associated with the development of rheumatoid arthritis; Network map of SARS-CoV-2 signaling pathway; Cell interactions of the pancreatic cancer microenvironment; Cytokines and inflammatory response; Primary ovarian insufficiency" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "17" "3" "1.051" "1.015" "0.918" "0.976" "0.903" "0.935" "1.041" "1.118" "0.424" "1015.6" "1067.5" "1030.7" "932.6" "990.7" "917.2" "949.5" "1057.3" "1135.1" "431.0" "" "" "" "" "" "" "" "" "" "" "607.8" "554.8" "570.8" "437.8" "459.2" "469.5" "441.5" "474.6" "615.8" "431.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1721823371863977969" "False" "High" "IsMasterProtein" "Q92973" "Transportin-1 OS=Homo sapiens OX=9606 GN=TNPO1 PE=1 SV=2" "0.000" "False" "20.234" "6" "5" "8" "5" "898" "102.3" "4.98" "18.73" "5" "transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf02985, Pf03810, Pf13513" "3842" "ENSG00000083312" "TNPO1" "B4DVC6; hsa:3842; Q92957; Q92973; Q92975" "22q11.2 copy number variation syndrome" "Postmitotic nuclear pore complex (NPC) reformation; Intraflagellar transport; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA" "4" "0" "1.136" "1.168" "1.001" "1.024" "1.086" "1.206" "0.616" "1.061" "5.062" "51.5" "58.5" "60.2" "51.6" "52.7" "55.9" "62.1" "31.7" "54.7" "260.8" "" "" "" "" "" "" "" "" "" "" "30.8" "30.4" "33.3" "24.2" "24.4" "28.6" "28.9" "14.2" "29.7" "260.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6184402302268645522" "False" "High" "IsMasterProtein" "Q5JRX3" "Presequence protease, mitochondrial OS=Homo sapiens OX=9606 GN=PITRM1 PE=1 SV=3" "0.000" "False" "20.227" "7" "7" "9" "7" "1037" "117.3" "6.92" "18.05" "7" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "enzyme regulator activity;other molecular function" "Pf00675, Pf05193, Pf08367" "10531" "ENSG00000107959" "PITRM1" "B3KMJ6; B4E0J8; C9JSL2; E7ES23; hsa:10531; O95204; Q2M2G6; Q4VBR1; Q5JRW7; Q5JRX3; Q7L5Z7; Q9BSI6; Q9BVJ5; Q9UPP8" "" "Mitochondrial protein import" "1" "0" "1.083" "1.186" "1.263" "1.089" "0.963" "1.069" "1.141" "1.148" "1.379" "123.1" "133.4" "146.0" "155.4" "134.1" "118.6" "131.6" "140.5" "141.4" "169.8" "" "" "" "" "" "" "" "" "" "" "73.7" "69.3" "80.9" "73.0" "62.2" "60.7" "61.2" "63.1" "76.7" "169.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6026735558710273601" "False" "High" "IsMasterProtein" "P36507" "Dual specificity mitogen-activated protein kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP2K2 PE=1 SV=1" "0.000" "False" "20.222" "20" "8" "17" "4" "400" "44.4" "6.55" "36.40" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "5605" "ENSG00000126934" "MAP2K2" "hsa:5605; P36507" "IL-5 signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Amyotrophic lateral sclerosis (ALS); Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; IL6 signaling pathway; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Kallmann syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "Signaling by BRAF and RAF1 fusions; Uptake and function of anthrax toxins; Signal transduction by L1; RAF activation; MAPK1 (ERK2) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Negative feedback regulation of MAPK pathway; Signaling by MAP2K mutants" "88" "2" "0.931" "0.767" "0.867" "1.051" "0.982" "1.081" "0.903" "0.989" "1.285" "955.7" "889.8" "732.6" "828.1" "1004.8" "938.4" "1033.2" "862.9" "945.6" "1228.1" "" "" "" "" "" "" "" "" "" "" "571.9" "462.4" "405.7" "388.8" "465.8" "480.4" "480.4" "387.4" "513.0" "1228.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3741204735065001472" "False" "High" "IsMasterProtein" "Q8WXF1" "Paraspeckle component 1 OS=Homo sapiens OX=9606 GN=PSPC1 PE=1 SV=1" "0.000" "False" "20.180" "12" "6" "15" "5" "523" "58.7" "6.67" "27.65" "6" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08075" "55269" "ENSG00000121390" "PSPC1" "hsa:55269; Q5JTQ3; Q8NCZ9; Q8WXE8; Q8WXF1; Q9NV36" "" "" "0" "0" "1.154" "1.335" "1.119" "1.203" "1.134" "1.094" "0.815" "1.062" "4.391" "250.4" "289.0" "334.3" "280.2" "301.1" "283.9" "273.9" "204.1" "265.9" "1099.5" "" "" "" "" "" "" "" "" "" "" "149.8" "150.2" "185.2" "131.5" "139.6" "145.3" "127.3" "91.6" "144.3" "1099.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "419048109363271085" "False" "High" "IsMasterProtein" "Q10713" "Mitochondrial-processing peptidase subunit alpha OS=Homo sapiens OX=9606 GN=PMPCA PE=1 SV=2" "0.000" "False" "20.173" "12" "7" "12" "7" "525" "58.2" "6.92" "29.03" "7" "protein metabolism;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf00675, Pf05193" "23203" "ENSG00000165688" "PMPCA" "B4DKL3; E7ET61; hsa:23203; Q10713; Q16639; Q5SXM9; Q8N513" "" "Mitochondrial protein import; Mitochondrial protein degradation; Processing of SMDT1" "3" "0" "0.883" "0.969" "0.958" "0.966" "1.071" "1.109" "0.774" "0.966" "2.500" "286.2" "252.8" "277.5" "274.2" "276.6" "306.7" "317.4" "221.6" "276.4" "715.5" "" "" "" "" "" "" "" "" "" "" "171.3" "131.3" "153.7" "128.7" "128.2" "157.0" "147.6" "99.5" "150.0" "715.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5588374002070682198" "False" "High" "IsMasterProtein" "P63000" "Ras-related C3 botulinum toxin substrate 1 OS=Homo sapiens OX=9606 GN=RAC1 PE=1 SV=1" "0.000" "False" "20.171" "39" "7" "18" "3" "192" "21.4" "8.50" "38.32" "7" "cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5879" "ENSG00000136238" "RAC1" "hsa:5879; O95501; P15154; P63000; Q3Y4D3; Q5JAA8; Q9BTB4" "Androgen receptor signaling pathway; Nucleotide-binding oligomerization domain (NOD) pathway; Target of rapamycin signaling; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; RalA downstream regulated genes; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; Amyotrophic lateral sclerosis (ALS); Cardiac hypertrophic response; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; Robo4 and VEGF signaling pathways crosstalk; p38 MAPK signaling pathway; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Ciliary landscape; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; Leukocyte-intrinsic Hippo pathway functions; Neural crest cell migration during development; Neural crest cell migration in cancer; Gastrin signaling pathway; Melanoma; Netrin-UNC5B signaling pathway; Insulin signaling; CAMKK2 pathway; Opioid receptor pathways; Regulation of actin cytoskeleton; GDNF signaling; 2q13 copy number variation syndrome; 2q21.1 copy number variation syndrome; 2q37 copy number variation syndrome; G13 signaling pathway; Genetic causes of porto-sinusoidal vascular disease; TROP2 regulatory signaling; 13q12.12 copy number variation; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; Interferon type I signaling pathways; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling; Neutrophil degranulation; MAPK6/MAPK4 signaling; Factors involved in megakaryocyte development and platelet production; FCERI mediated MAPK activation; RAC1 GTPase cycle; NRAGE signals death through JNK; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; DCC mediated attractive signaling; GPVI-mediated activation cascade; Signaling by SCF-KIT; DAP12 signaling; Ephrin signaling; RHO GTPases activate CIT; PCP/CE pathway; WNT5:FZD7-mediated leishmania damping; EPH-ephrin mediated repulsion of cells; Sema3A PAK dependent Axon repulsion; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Signal transduction by L1; RHO GTPases activate PKNs; RHO GTPases activate PAKs; DSCAM interactions; Azathioprine ADME; VEGFR2 mediated vascular permeability; Sema4D mediated inhibition of cell attachment and migration; Inactivation of CDC42 and RAC1; Activation of RAC1; CD28 dependent Vav1 pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Nef and signal transduction; RHO GTPases Activate NADPH Oxidases; NTRK2 activates RAC1; MET activates RAP1 and RAC1; Activation of RAC1 downstream of NMDARs; Activated NTRK2 signals through CDK5; RHO GTPases activate KTN1" "113" "2" "1.082" "0.973" "1.171" "1.005" "0.994" "1.072" "1.066" "1.070" "1.012" "668.2" "723.3" "650.4" "782.4" "671.4" "664.6" "716.1" "712.4" "714.9" "676.1" "" "" "" "" "" "" "" "" "" "" "399.9" "375.9" "360.2" "367.3" "311.2" "340.2" "333.0" "319.8" "387.9" "676.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2662746858814386989" "False" "High" "IsMasterProtein" "Q15024" "Exosome complex component RRP42 OS=Homo sapiens OX=9606 GN=EXOSC7 PE=1 SV=3" "0.000" "False" "20.129" "24" "6" "7" "6" "291" "31.8" "5.19" "19.52" "6" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "23016" "ENSG00000075914" "EXOSC7" "hsa:23016; Q15024; Q96E72" "Ciliary landscape" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "7" "0" "0.967" "0.925" "0.873" "0.991" "0.912" "0.906" "1.020" "0.932" "0.510" "404.5" "391.1" "374.3" "353.1" "400.9" "368.9" "366.5" "412.7" "377.1" "206.4" "" "" "" "" "" "" "" "" "" "" "242.0" "203.2" "207.3" "165.8" "185.8" "188.8" "170.4" "185.3" "204.6" "206.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3173318319984318675" "False" "High" "IsMasterProtein" "Q9BXR0" "Queuine tRNA-ribosyltransferase catalytic subunit 1 OS=Homo sapiens OX=9606 GN=QTRT1 PE=1 SV=3" "0.000" "False" "20.117" "10" "3" "6" "3" "403" "44.0" "7.23" "14.61" "3" "RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01702" "81890" "ENSG00000213339" "QTRT1" "B4DFM7; hsa:81890; Q96BQ4; Q9BXQ9; Q9BXR0" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.944" "1.129" "1.019" "0.928" "1.114" "1.018" "0.893" "0.968" "0.638" "91.0" "85.9" "102.7" "92.7" "84.4" "101.3" "92.6" "81.3" "88.1" "58.1" "" "" "" "" "" "" "" "" "" "" "54.4" "44.6" "56.9" "43.5" "39.1" "51.9" "43.1" "36.5" "47.8" "58.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4892989875718200247" "False" "High" "IsMasterProtein" "Q9UL46" "Proteasome activator complex subunit 2 OS=Homo sapiens OX=9606 GN=PSME2 PE=1 SV=4" "0.000" "False" "20.112" "21" "5" "13" "5" "239" "27.4" "5.73" "27.05" "5" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02251, Pf02252" "5721" "ENSG00000100911; ENSG00000284889" "PSME2" "hsa:5721; Q15129; Q9UL46" "Proteasome degradation" "Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; UCH proteinases; Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Hedgehog 'on' state; Regulation of RAS by GAPs; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of PTEN stability and activity; Regulation of expression of SLITs and ROBOs; KEAP1-NFE2L2 pathway; Somitogenesis; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity" "61" "0" "1.168" "0.976" "0.980" "1.267" "1.195" "1.177" "1.242" "1.274" "1.261" "435.6" "509.0" "425.3" "427.0" "551.9" "520.7" "512.7" "541.2" "554.8" "549.2" "" "" "" "" "" "" "" "" "" "" "260.7" "264.5" "235.5" "200.4" "255.8" "266.6" "238.4" "243.0" "301.0" "549.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-681400762000750361" "False" "High" "IsMasterProtein" "O60749" "Sorting nexin-2 OS=Homo sapiens OX=9606 GN=SNX2 PE=1 SV=2" "0.000" "False" "20.060" "10" "4" "5" "4" "519" "58.4" "5.12" "14.65" "4" "cell organization and biogenesis;transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf03700, Pf09325" "6643" "ENSG00000205302" "SNX2" "B3KN44; B4DEK4; B7Z408; hsa:6643; O43650; O60749; P82862; Q53XK8; Q597H6; Q9BTS8" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "1.267" "1.313" "1.371" "1.311" "1.274" "1.412" "0.985" "1.277" "6.734" "111.9" "141.8" "147.0" "153.4" "146.7" "142.6" "158.0" "110.2" "142.9" "753.5" "" "" "" "" "" "" "" "" "" "" "67.0" "73.7" "81.4" "72.0" "68.0" "73.0" "73.4" "49.5" "77.5" "753.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1575369473679167499" "False" "High" "IsMasterProtein" "Q00059" "Transcription factor A, mitochondrial OS=Homo sapiens OX=9606 GN=TFAM PE=1 SV=1" "0.000" "False" "20.029" "23" "7" "13" "7" "246" "29.1" "9.72" "26.03" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "7019" "ENSG00000108064" "TFAM" "A8MRB2; A9QXC6; B5BU05; hsa:7019; Q00059; Q5U0C6" "Energy metabolism; NAD metabolism, sirtuins and aging; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Orexin receptor pathway; Sildenafil treatment" "Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation" "9" "0" "0.980" "0.921" "0.883" "1.014" "0.981" "0.939" "0.974" "0.888" "0.564" "1282.3" "1256.7" "1180.9" "1132.1" "1300.2" "1258.0" "1203.6" "1248.3" "1138.1" "722.8" "" "" "" "" "" "" "" "" "" "" "767.4" "653.0" "654.0" "531.5" "602.7" "644.0" "559.7" "560.4" "617.5" "722.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7869799461247912985" "False" "High" "IsMasterProtein" "Q96GW9" "Methionine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=MARS2 PE=1 SV=2" "0.000" "False" "19.952" "10" "5" "6" "5" "593" "66.5" "8.09" "19.80" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf09334, Pf19303" "92935" "ENSG00000247626" "MARS2" "A0AVC3; hsa:92935; Q76E79; Q8IW62; Q8N7N4; Q96GW9" "Amino acid metabolism" "Mitochondrial tRNA aminoacylation" "2" "0" "0.939" "0.916" "1.007" "0.972" "0.997" "1.034" "0.854" "0.987" "0.665" "426.0" "400.1" "390.0" "429.2" "414.2" "424.8" "440.5" "363.7" "420.5" "283.2" "" "" "" "" "" "" "" "" "" "" "254.9" "207.9" "216.0" "201.5" "192.0" "217.5" "204.8" "163.3" "228.1" "283.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7061207721996529093" "False" "High" "IsMasterProtein" "P08758" "Annexin A5 OS=Homo sapiens OX=9606 GN=ANXA5 PE=1 SV=2" "0.000" "False" "19.950" "18" "7" "11" "7" "320" "35.9" "5.05" "25.06" "7" "stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00191" "308" "ENSG00000164111" "ANXA5" "D3DNW7; hsa:308; P08758; Q6FHB3; Q6FI16; Q8WV69; Q9UDH9" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Interactions between LOXL4 and oxidative stress pathway; Prostaglandin synthesis and regulation" "Platelet degranulation" "4" "0" "1.080" "1.125" "1.148" "1.157" "1.100" "1.069" "0.640" "1.106" "5.735" "263.0" "284.1" "296.0" "302.0" "304.4" "289.3" "281.1" "168.3" "290.8" "1508.5" "" "" "" "" "" "" "" "" "" "" "157.4" "147.6" "163.9" "141.8" "141.1" "148.1" "130.7" "75.6" "157.8" "1508.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2034922387344060046" "False" "High" "IsMasterProtein" "P12955" "Xaa-Pro dipeptidase OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=3" "0.000" "False" "19.935" "12" "5" "8" "5" "493" "54.5" "6.00" "23.95" "5" "protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf00557, Pf05195" "5184" "ENSG00000124299" "PEPD" "A8K3Z1; A8K416; A8K696; A8MX47; B4DDB7; B4DGJ1; E9PCE8; hsa:5184; P12955; Q8TBN9; Q9BT75" "" "" "0" "0" "1.023" "0.959" "0.945" "0.986" "0.863" "1.114" "0.952" "1.160" "0.679" "839.5" "858.7" "804.8" "793.6" "827.4" "724.8" "934.9" "799.6" "973.5" "570.4" "" "" "" "" "" "" "" "" "" "" "502.4" "446.2" "445.7" "372.6" "383.5" "371.1" "434.7" "359.0" "528.2" "570.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-15854148761745197" "False" "High" "IsMasterProtein" "Q6IN85" "Serine/threonine-protein phosphatase 4 regulatory subunit 3A OS=Homo sapiens OX=9606 GN=PPP4R3A PE=1 SV=1" "0.000" "False" "19.899" "9" "7" "9" "7" "833" "95.3" "4.94" "16.83" "7" "stress response" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf04802" "55671" "ENSG00000100796" "PPP4R3A" "hsa:55671; Q69YK6; Q6IN85; Q86U23; Q86YI7; Q8IVG1; Q9H3F1; Q9H7U8; Q9NV01; Q9NWP1" "16p11.2 proximal deletion syndrome" "" "1" "0" "1.078" "1.168" "1.116" "1.131" "1.106" "1.067" "1.077" "0.902" "1.576" "243.3" "262.3" "284.2" "271.4" "275.2" "269.1" "259.6" "262.0" "219.4" "383.4" "" "" "" "" "" "" "" "" "" "" "145.6" "136.3" "157.4" "127.4" "127.6" "137.7" "120.7" "117.6" "119.0" "383.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "545176652009721876" "False" "High" "IsMasterProtein" "Q9P013" "Spliceosome-associated protein CWC15 homolog OS=Homo sapiens OX=9606 GN=CWC15 PE=1 SV=2" "0.000" "False" "19.870" "17" "4" "7" "4" "229" "26.6" "5.71" "22.86" "4" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf04889" "51503" "ENSG00000150316" "CWC15" "B2RC17; hsa:51503; Q05BV9; Q05DM1; Q9P013; Q9UI29" "" "mRNA Splicing - Major Pathway" "1" "0" "0.910" "0.945" "1.031" "0.964" "1.075" "1.028" "1.138" "0.913" "0.341" "387.2" "352.5" "365.7" "399.2" "373.4" "416.1" "398.1" "440.8" "353.6" "132.0" "" "" "" "" "" "" "" "" "" "" "231.7" "183.2" "202.5" "187.4" "173.1" "213.0" "185.1" "197.9" "191.9" "132.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7785444937320200778" "False" "High" "IsMasterProtein" "P17544" "Cyclic AMP-dependent transcription factor ATF-7 OS=Homo sapiens OX=9606 GN=ATF7 PE=1 SV=3" "0.000" "False" "19.864" "9" "3" "4" "2" "483" "51.7" "8.00" "14.87" "3" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "11016" "ENSG00000170653" "ATF7" "A5D6Y4; B2RMP1; B4DQL4; hsa:11016; P17544; Q13814; Q8IVR8; Q9UD83" "" "" "0" "1" "1.424" "1.232" "1.136" "1.305" "1.251" "1.340" "1.251" "1.207" "1.250" "137.8" "196.2" "169.7" "156.6" "179.9" "172.4" "184.6" "172.3" "166.3" "172.2" "" "" "" "" "" "" "" "" "" "" "82.5" "101.9" "94.0" "73.5" "83.4" "88.2" "85.8" "77.4" "90.2" "172.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570551838394526128" "False" "High" "IsMasterProtein" "Q86VN1" "Vacuolar protein-sorting-associated protein 36 OS=Homo sapiens OX=9606 GN=VPS36 PE=1 SV=1" "0.000" "False" "19.855" "14" "5" "7" "5" "386" "43.8" "7.20" "17.54" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf04157, Pf11605" "51028" "ENSG00000136100" "VPS36" "A8K125; hsa:51028; Q3ZCV7; Q5H9S1; Q5VXB6; Q86VN1; Q9H8Z5; Q9Y3E3" "Network map of SARS-CoV-2 signaling pathway" "Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events" "3" "0" "1.059" "1.002" "1.138" "1.088" "1.058" "1.111" "0.970" "1.080" "2.110" "164.1" "173.8" "164.3" "186.8" "178.5" "173.6" "182.3" "159.2" "177.2" "346.1" "" "" "" "" "" "" "" "" "" "" "98.2" "90.3" "91.0" "87.7" "82.7" "88.9" "84.8" "71.5" "96.1" "346.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4704340040215325088" "False" "High" "IsMasterProtein" "Q9GZN8" "Adipose-secreted signaling protein OS=Homo sapiens OX=9606 GN=ADISSP PE=1 SV=3" "0.000" "False" "19.851" "27" "4" "6" "4" "174" "19.3" "6.84" "16.91" "4" "other metabolic processes;other biological processes" "non-structural extracellular" "other molecular function" "Pf15006" "54976" "ENSG00000101220" "ADISSP" "A8K4J0; D3DVX8; hsa:54976; Q5JX81; Q9GZN8; Q9NWX3" "" "" "0" "0" "0.965" "1.072" "1.309" "0.969" "1.139" "1.044" "1.222" "1.232" "1.024" "90.6" "87.4" "97.1" "118.6" "87.8" "103.1" "94.6" "110.6" "111.6" "92.7" "" "" "" "" "" "" "" "" "" "" "54.2" "45.4" "53.8" "55.7" "40.7" "52.8" "44.0" "49.7" "60.5" "92.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3553931004733427798" "False" "High" "IsMasterProtein" "P62306" "Small nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=SNRPF PE=1 SV=1" "0.000" "False" "19.825" "24" "3" "17" "3" "86" "9.7" "4.67" "33.63" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "6636" "ENSG00000139343" "SNRPF" "A2VCR2; B2R498; hsa:6636; P62306; Q15356; Q6IBQ1; Q6P4I0" "mRNA processing" "snRNP Assembly; mRNA Splicing - Major Pathway; RNA Polymerase II Transcription Termination; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "0.998" "1.024" "0.968" "1.018" "1.027" "1.064" "1.050" "1.101" "0.728" "476.2" "475.1" "487.7" "460.8" "484.7" "489.1" "506.5" "500.0" "524.5" "346.5" "" "" "" "" "" "" "" "" "" "" "285.0" "246.9" "270.1" "216.3" "224.7" "250.4" "235.5" "224.5" "284.6" "346.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "315483607845859686" "False" "High" "IsMasterProtein" "Q9BRF8" "Serine/threonine-protein phosphatase CPPED1 OS=Homo sapiens OX=9606 GN=CPPED1 PE=1 SV=3" "0.000" "False" "19.695" "17" "6" "8" "6" "314" "35.5" "6.20" "18.46" "6" "" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle" "other molecular function" "Pf00149" "55313" "ENSG00000103381" "CPPED1" "B4DQ68; hsa:55313; Q6MZY9; Q9BRF8; Q9H9M9; Q9NUT6" "" "Neutrophil degranulation" "1" "0" "0.877" "0.794" "0.874" "0.947" "0.707" "1.286" "0.857" "1.085" "0.509" "640.2" "561.3" "508.5" "559.5" "606.4" "452.8" "823.3" "548.5" "694.7" "325.9" "" "" "" "" "" "" "" "" "" "" "383.1" "291.7" "281.6" "262.7" "281.1" "231.8" "382.8" "246.2" "376.9" "325.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "779852501093026521" "False" "High" "IsMasterProtein" "P15153" "Ras-related C3 botulinum toxin substrate 2 OS=Homo sapiens OX=9606 GN=RAC2 PE=1 SV=1" "0.000" "False" "19.645" "31" "6" "24" "2" "192" "21.4" "7.61" "62.56" "6" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00071" "5880" "ENSG00000128340" "RAC2" "hsa:5880; P15153; Q9UDJ4" "Integrin-mediated cell adhesion; RalA downstream regulated genes; B cell receptor signaling pathway; Focal adhesion; MAPK signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; Macrophage markers; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Insulin signaling; Regulation of actin cytoskeleton; Pathways in cancer; DNA damage response (only ATM dependent)" "RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; PCP/CE pathway; ROS and RNS production in phagocytes; RHO GTPases Activate NADPH Oxidases" "24" "0" "1.113" "1.053" "1.076" "1.078" "1.010" "1.075" "0.896" "0.990" "1.560" "911.9" "1015.4" "960.1" "980.8" "982.9" "921.2" "980.3" "817.3" "902.6" "1422.9" "" "" "" "" "" "" "" "" "" "" "545.7" "527.6" "531.7" "460.4" "455.6" "471.6" "455.8" "366.9" "489.7" "1422.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9216601272429108085" "False" "High" "IsMasterProtein" "Q96GX9" "Methylthioribulose-1-phosphate dehydratase OS=Homo sapiens OX=9606 GN=APIP PE=1 SV=1" "0.000" "False" "19.557" "25" "5" "10" "5" "242" "27.1" "7.12" "24.85" "5" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00596" "51074" "ENSG00000149089" "APIP" "A8K9D3; hsa:51074; Q6PJX6; Q8WVU2; Q96GX9; Q96HK2; Q9Y318" "Methionine de novo and salvage pathway" "Regulation of the apoptosome activity; Methionine salvage pathway" "4" "0" "0.962" "0.975" "0.957" "0.964" "0.902" "1.050" "0.958" "0.925" "0.492" "601.3" "578.8" "586.0" "575.6" "579.8" "542.5" "631.5" "576.3" "556.5" "295.6" "" "" "" "" "" "" "" "" "" "" "359.9" "300.8" "324.5" "270.2" "268.7" "277.7" "293.6" "258.7" "301.9" "295.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6978047849896927875" "False" "High" "IsMasterProtein" "O15234" "Protein CASC3 OS=Homo sapiens OX=9606 GN=CASC3 PE=1 SV=2" "0.000" "False" "19.542" "10" "5" "6" "5" "703" "76.2" "6.48" "16.13" "5" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09405" "22794" "ENSG00000108349" "CASC3" "A8K8R0; O15234" "" "Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "6" "0" "0.764" "0.898" "0.976" "0.973" "1.040" "0.920" "1.044" "0.750" "0.732" "122.1" "93.3" "109.7" "119.2" "118.8" "127.0" "112.4" "127.4" "91.6" "89.4" "" "" "" "" "" "" "" "" "" "" "73.1" "48.5" "60.7" "55.9" "55.1" "65.0" "52.3" "57.2" "49.7" "89.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1760362922626917016" "False" "High" "IsMasterProtein" "Q14011" "Cold-inducible RNA-binding protein OS=Homo sapiens OX=9606 GN=CIRBP PE=1 SV=1" "0.000" "False" "19.473" "21" "3" "9" "3" "172" "18.6" "9.51" "20.55" "3" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "1153" "ENSG00000099622" "CIRBP" "B3KT17; B4E2X2; hsa:1153; Q14011" "" "" "0" "0" "1.094" "1.187" "1.108" "1.106" "1.156" "1.093" "1.381" "0.996" "0.617" "252.3" "276.0" "299.5" "279.5" "279.1" "291.7" "275.8" "348.3" "251.2" "155.7" "" "" "" "" "" "" "" "" "" "" "151.0" "143.4" "165.9" "131.2" "129.4" "149.3" "128.2" "156.4" "136.3" "155.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7926750901402698685" "False" "High" "IsMasterProtein" "Q9UKG1" "DCC-interacting protein 13-alpha OS=Homo sapiens OX=9606 GN=APPL1 PE=1 SV=1" "0.000" "False" "19.471" "10" "5" "8" "5" "709" "79.6" "5.41" "15.72" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00640, Pf16746" "26060" "ENSG00000157500" "APPL1" "hsa:26060; Q9P2B9; Q9UKG1" "Follicle stimulating hormone (FSH) signaling pathway; Chromosomal and microsatellite instability in colorectal cancer" "Caspase activation via Dependence Receptors in the absence of ligand" "3" "0" "0.680" "0.809" "0.910" "0.839" "1.003" "0.905" "0.810" "0.892" "1.729" "105.4" "71.7" "85.3" "95.9" "88.5" "105.8" "95.4" "85.4" "94.1" "182.3" "" "" "" "" "" "" "" "" "" "" "63.1" "37.3" "47.2" "45.0" "41.0" "54.2" "44.4" "38.3" "51.1" "182.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4154359228263867930" "False" "High" "IsMasterProtein" "P46781" "Small ribosomal subunit protein uS4 OS=Homo sapiens OX=9606 GN=RPS9 PE=1 SV=3" "0.000" "False" "19.452" "30" "7" "12" "7" "194" "22.6" "10.65" "19.91" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00163, Pf01479" "6203" "ENSG00000170889; ENSG00000274005; ENSG00000274626; ENSG00000274646; ENSG00000274950; ENSG00000275323; ENSG00000277079; ENSG00000277359; ENSG00000278081; ENSG00000278270" "RPS9" "A9C4C1; hsa:6203; P46781; Q4QRK7; Q9BVZ0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "20" "0" "0.935" "0.874" "0.876" "0.925" "0.819" "0.950" "0.743" "1.011" "1.323" "230.1" "215.0" "201.0" "201.4" "212.8" "188.4" "218.5" "170.8" "232.6" "304.4" "" "" "" "" "" "" "" "" "" "" "137.7" "111.7" "111.3" "94.6" "98.6" "96.5" "101.6" "76.7" "126.2" "304.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8529586358305545684" "False" "High" "IsMasterProtein" "P04181" "Ornithine aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=OAT PE=1 SV=1" "0.000" "False" "19.449" "10" "4" "8" "4" "439" "48.5" "7.03" "20.06" "4" "other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00202" "4942" "ENSG00000065154" "OAT" "D3DRF0; hsa:4942; P04181; Q16068; Q16069; Q68CS0; Q6IAV9; Q9UD03" "Amino acid metabolism; 22q11.2 copy number variation syndrome; Creatine pathway" "Glutamate and glutamine metabolism" "4" "0" "1.056" "0.969" "0.929" "0.996" "0.987" "1.026" "0.977" "0.943" "0.901" "356.3" "376.1" "345.3" "331.0" "354.8" "351.6" "365.4" "348.2" "336.0" "321.0" "" "" "" "" "" "" "" "" "" "" "213.2" "195.5" "191.2" "155.4" "164.4" "180.0" "169.9" "156.3" "182.3" "321.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7100137965290358990" "False" "High" "IsMasterProtein" "Q9UJW0" "Dynactin subunit 4 OS=Homo sapiens OX=9606 GN=DCTN4 PE=1 SV=1" "0.000" "False" "19.426" "14" "5" "12" "5" "460" "52.3" "7.34" "24.70" "5" "" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf05502" "51164" "ENSG00000132912" "DCTN4" "B3KWW0; D3DQH0; E5RGT5; hsa:51164; Q8TAN8; Q9UJW0" "Vasopressin-regulated water reabsorption" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; MHC class II antigen presentation; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic" "5" "0" "1.001" "0.977" "0.844" "0.947" "0.886" "0.953" "1.014" "1.052" "0.833" "314.2" "314.4" "306.8" "265.1" "297.7" "278.5" "299.3" "318.5" "330.4" "261.6" "" "" "" "" "" "" "" "" "" "" "188.0" "163.4" "169.9" "124.5" "138.0" "142.6" "139.2" "143.0" "179.3" "261.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7302016058410828571" "False" "High" "IsMasterProtein" "O75940" "Survival of motor neuron-related-splicing factor 30 OS=Homo sapiens OX=9606 GN=SMNDC1 PE=1 SV=1" "0.000" "False" "19.425" "13" "3" "8" "3" "238" "26.7" "7.24" "24.51" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf06003" "10285" "ENSG00000119953" "SMNDC1" "B2RA27; D3DRB1; hsa:10285; O75940; Q5T3K6" "" "mRNA Splicing - Major Pathway" "1" "0" "0.954" "1.036" "0.926" "1.008" "1.064" "1.024" "1.052" "1.020" "0.446" "533.6" "508.9" "553.1" "494.0" "538.0" "567.8" "546.4" "561.3" "544.4" "238.2" "" "" "" "" "" "" "" "" "" "" "319.3" "264.4" "306.3" "231.9" "249.4" "290.7" "254.1" "252.0" "295.4" "238.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1907773996049463670" "False" "High" "IsMasterProtein" "O43504" "Ragulator complex protein LAMTOR5 OS=Homo sapiens OX=9606 GN=LAMTOR5 PE=1 SV=1" "0.000" "False" "19.408" "55" "3" "4" "3" "91" "9.6" "4.87" "15.94" "3" "cell organization and biogenesis;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf16672" "10542" "ENSG00000134248" "LAMTOR5" "A0A0C4DGV4; hsa:10542; O43504; Q6IBD8" "" "Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "7" "0" "0.925" "0.893" "0.955" "0.950" "1.032" "1.144" "0.989" "0.832" "0.537" "289.3" "267.7" "258.3" "276.2" "274.9" "298.5" "331.0" "286.2" "240.7" "155.4" "" "" "" "" "" "" "" "" "" "" "173.1" "139.1" "143.0" "129.7" "127.4" "152.8" "153.9" "128.5" "130.6" "155.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6326411103029325143" "False" "High" "IsMasterProtein" "P53602" "Diphosphomevalonate decarboxylase OS=Homo sapiens OX=9606 GN=MVD PE=1 SV=1" "0.000" "False" "19.401" "18" "7" "10" "7" "400" "43.4" "7.23" "20.83" "7" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00288, Pf18376" "4597" "ENSG00000167508" "MVD" "P53602; Q53Y65" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Mevalonate pathway; Aspirin and miRNAs; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis; Synthesis of Dolichyl-phosphate" "11" "0" "0.961" "0.951" "1.162" "0.943" "1.055" "1.038" "1.072" "1.121" "0.931" "533.2" "512.4" "506.8" "619.4" "502.9" "562.5" "553.4" "571.5" "597.9" "496.2" "" "" "" "" "" "" "" "" "" "" "319.1" "266.3" "280.7" "290.8" "233.1" "288.0" "257.3" "256.6" "324.4" "496.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6910881260683280979" "False" "High" "IsMasterProtein" "Q9UEE9" "Craniofacial development protein 1 OS=Homo sapiens OX=9606 GN=CFDP1 PE=1 SV=1" "0.000" "False" "19.394" "17" "5" "9" "5" "299" "33.6" "4.81" "22.77" "5" "cell adhesion;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf07572" "10428" "ENSG00000153774" "CFDP1" "hsa:10428; O00393; O00404; Q9UEE9; Q9UEF0; Q9UEF1; Q9UEF8" "" "" "0" "0" "1.025" "1.021" "1.005" "1.003" "1.015" "1.012" "1.041" "0.885" "0.569" "377.5" "386.7" "385.2" "379.2" "378.5" "383.0" "382.0" "392.8" "334.2" "214.7" "" "" "" "" "" "" "" "" "" "" "225.9" "201.0" "213.3" "178.0" "175.4" "196.0" "177.6" "176.3" "181.3" "214.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7011076575076357199" "False" "High" "IsMasterProtein" "O00442" "RNA 3'-terminal phosphate cyclase OS=Homo sapiens OX=9606 GN=RTCA PE=1 SV=1" "0.000" "False" "19.342" "14" "6" "10" "6" "366" "39.3" "7.85" "20.89" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01137, Pf05189" "8634" "ENSG00000137996" "RTCA" "hsa:8634; O00442; Q5VVL5; Q5VVL6; Q96E99" "" "" "0" "0" "1.114" "0.994" "1.036" "1.067" "1.064" "1.080" "1.096" "1.071" "0.761" "611.0" "680.9" "607.3" "633.0" "652.3" "650.0" "660.2" "669.7" "654.4" "465.0" "" "" "" "" "" "" "" "" "" "" "365.7" "353.9" "336.3" "297.2" "302.3" "332.8" "307.0" "300.7" "355.0" "465.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "51923672491572090" "False" "High" "IsMasterProtein" "Q4J6C6" "Prolyl endopeptidase-like OS=Homo sapiens OX=9606 GN=PREPL PE=1 SV=1" "0.000" "False" "19.341" "8" "5" "6" "5" "727" "83.9" "6.38" "18.33" "5" "protein metabolism;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus" "other molecular function" "Pf00326, Pf02897" "9581" "ENSG00000138078" "PREPL" "A7E2X6; D6W5A3; hsa:9581; O43163; Q4J6C3; Q4J6C4; Q4J6C6; Q4ZG39; Q6ZMW7; Q96DW7" "Primary ovarian insufficiency" "" "1" "0" "1.076" "0.957" "1.059" "0.899" "1.168" "0.994" "0.960" "1.038" "1.128" "133.4" "143.6" "127.6" "141.3" "119.9" "155.9" "132.7" "128.1" "138.5" "150.5" "" "" "" "" "" "" "" "" "" "" "79.9" "74.6" "70.7" "66.3" "55.6" "79.8" "61.7" "57.5" "75.1" "150.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7558389581764573434" "False" "High" "IsMasterProtein" "P18858" "DNA ligase 1 OS=Homo sapiens OX=9606 GN=LIG1 PE=1 SV=1" "0.000" "False" "19.313" "7" "6" "6" "6" "919" "101.7" "5.62" "16.48" "6" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01068, Pf04675, Pf04679" "3978" "ENSG00000105486" "LIG1" "B2RAI8; B4DTU4; hsa:3978; P18858; Q2TB12; Q32P23" "Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Gap-filling DNA repair synthesis and ligation in TC-NER; Early Phase of HIV Life Cycle; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Processive synthesis on the lagging strand; Gap-filling DNA repair synthesis and ligation in GG-NER; Processive synthesis on the C-strand of the telomere; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "14" "0" "0.968" "0.921" "1.107" "1.349" "1.130" "1.071" "0.689" "0.888" "5.524" "90.0" "87.1" "82.9" "99.6" "121.4" "101.7" "96.4" "62.0" "79.9" "496.9" "" "" "" "" "" "" "" "" "" "" "53.8" "45.3" "45.9" "46.8" "56.3" "52.1" "44.8" "27.8" "43.3" "496.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5258533483115152097" "False" "High" "IsMasterProtein" "Q53H96" "Pyrroline-5-carboxylate reductase 3 OS=Homo sapiens OX=9606 GN=PYCR3 PE=1 SV=3" "0.000" "False" "19.243" "26" "6" "9" "6" "274" "28.6" "7.72" "17.28" "6" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf03807, Pf14748" "65263" "ENSG00000104524; ENSG00000276657" "PYCR3" "B3KMB5; B4DVT6; H0Y6C3; hsa:65263; Q53H96; Q8N3N9; Q96HX4; Q9H896" "" "Glutamate and glutamine metabolism" "1" "0" "0.918" "0.846" "0.938" "0.993" "1.016" "1.051" "0.861" "0.929" "0.597" "234.6" "215.3" "198.5" "220.1" "233.0" "238.4" "246.7" "201.9" "217.9" "140.1" "" "" "" "" "" "" "" "" "" "" "140.4" "111.9" "109.9" "103.3" "108.0" "122.0" "114.7" "90.6" "118.2" "140.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7460825629413537855" "False" "High" "IsMasterProtein" "Q9BV40" "Vesicle-associated membrane protein 8 OS=Homo sapiens OX=9606 GN=VAMP8 PE=1 SV=1" "0.000" "False" "19.236" "39" "4" "7" "4" "100" "11.4" "7.34" "26.43" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957" "8673" "ENSG00000118640" "VAMP8" "hsa:8673; O60625; Q53SP9; Q6IB09; Q9BV40" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "Neutrophil degranulation; ER-Phagosome pathway; Cargo recognition for clathrin-mediated endocytosis; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis" "8" "0" "1.053" "0.973" "1.021" "1.039" "0.952" "1.063" "1.103" "0.978" "0.438" "1210.0" "1274.6" "1177.8" "1236.0" "1256.7" "1151.6" "1285.9" "1335.0" "1183.3" "529.4" "" "" "" "" "" "" "" "" "" "" "724.1" "662.4" "652.3" "580.3" "582.5" "589.5" "597.9" "599.3" "642.0" "529.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1310996743308863221" "False" "High" "IsMasterProtein" "Q9Y3A5" "Ribosome maturation protein SBDS OS=Homo sapiens OX=9606 GN=SBDS PE=1 SV=4" "0.000" "False" "19.157" "24" "8" "10" "8" "250" "28.7" "8.75" "23.53" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;translation activity;nucleic acid binding activity" "Pf01172, Pf09377, Pf20268" "51119" "ENSG00000126524" "SBDS" "A8K0P4; Q96FX0; Q9NV53; Q9Y3A5" "Genetic causes of porto-sinusoidal vascular disease" "" "1" "0" "1.155" "1.372" "1.116" "1.302" "1.110" "1.072" "0.826" "1.194" "3.962" "318.9" "368.3" "437.6" "356.0" "415.3" "354.1" "341.7" "263.3" "380.8" "1263.4" "" "" "" "" "" "" "" "" "" "" "190.8" "191.4" "242.3" "167.1" "192.5" "181.3" "158.9" "118.2" "206.6" "1263.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1328397515797573102" "False" "High" "IsMasterProtein" "A6NDG6" "Glycerol-3-phosphate phosphatase OS=Homo sapiens OX=9606 GN=PGP PE=1 SV=1" "0.000" "False" "19.143" "22" "5" "7" "5" "321" "34.0" "6.14" "20.61" "5" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf13242, Pf13344" "283871" "ENSG00000184207" "PGP" "A6NDG6; hsa:283871" "" "Glycolysis" "1" "0" "1.076" "0.991" "1.140" "0.959" "1.026" "1.002" "0.993" "0.985" "0.672" "445.8" "479.6" "442.0" "508.1" "427.5" "457.3" "446.9" "442.8" "439.2" "299.7" "" "" "" "" "" "" "" "" "" "" "266.8" "249.2" "244.8" "238.5" "198.2" "234.1" "207.8" "198.8" "238.3" "299.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2329486021897558917" "False" "High" "IsMasterProtein" "P78347" "General transcription factor II-I OS=Homo sapiens OX=9606 GN=GTF2I PE=1 SV=2" "0.000" "False" "19.114" "6" "7" "9" "7" "998" "112.3" "6.39" "22.47" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02946" "2969" "ENSG00000263001" "GTF2I" "hsa:2969; O14743; O15359; O43546; O43588; O43589; P78347; Q75M85; Q75M86; Q75M87; Q75M88; Q86U51; Q9BSZ4" "B cell receptor signaling pathway; 7q11.23 copy number variation syndrome; Genetic causes of porto-sinusoidal vascular disease" "" "3" "0" "0.949" "1.069" "1.140" "1.030" "0.961" "1.014" "0.233" "0.991" "10.282" "70.3" "66.7" "75.1" "80.2" "72.4" "67.5" "71.3" "16.4" "69.7" "722.6" "" "" "" "" "" "" "" "" "" "" "42.1" "34.7" "41.6" "37.6" "33.5" "34.6" "33.2" "7.4" "37.8" "722.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "769140260772308897" "False" "High" "IsMasterProtein" "P07910" "Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Homo sapiens OX=9606 GN=HNRNPC PE=1 SV=4" "0.000" "False" "19.089" "16" "5" "8" "5" "306" "33.7" "5.08" "15.36" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "3183" "ENSG00000092199" "HNRNPC" "D3DS19; D3DS22; hsa:3183; P07910; P22628; Q53EX2; Q59FD3; Q5FWE8; Q86SF8; Q86U45; Q96HK7; Q96HM4; Q96IY5; Q9BTS3" "mRNA processing" "SUMOylation of RNA binding proteins; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "6" "0" "0.965" "1.073" "0.931" "1.006" "0.972" "0.967" "0.496" "1.023" "4.075" "188.3" "181.7" "201.9" "175.2" "189.4" "183.0" "182.0" "93.4" "192.6" "767.1" "" "" "" "" "" "" "" "" "" "" "112.7" "94.4" "111.8" "82.3" "87.8" "93.7" "84.6" "41.9" "104.5" "767.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2591250137459754120" "False" "High" "IsMasterProtein" "O43252" "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 OS=Homo sapiens OX=9606 GN=PAPSS1 PE=1 SV=2" "0.000" "False" "19.072" "9" "6" "6" "6" "624" "70.8" "6.86" "18.15" "6" "other metabolic processes;developmental processes" "cytosol" "kinase activity;other molecular function" "Pf01583, Pf01747, Pf14306" "9061" "ENSG00000138801" "PAPSS1" "hsa:9061; O43252; O43841; O75332; Q6IAX6; Q96FB1; Q96TF4; Q9P1P9; Q9UE98" "Sulfation biotransformation reaction" "Signaling by BRAF and RAF1 fusions; Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se" "4" "0" "0.913" "0.898" "0.833" "0.871" "1.008" "0.907" "0.991" "0.957" "0.589" "391.0" "357.1" "351.0" "325.5" "340.5" "394.0" "354.4" "387.4" "374.3" "230.3" "" "" "" "" "" "" "" "" "" "" "234.0" "185.6" "194.4" "152.8" "157.8" "201.7" "164.8" "173.9" "203.1" "230.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8751597953454221886" "False" "High" "IsMasterProtein" "P09496" "Clathrin light chain A OS=Homo sapiens OX=9606 GN=CLTA PE=1 SV=1" "0.000" "False" "19.039" "19" "6" "26" "6" "248" "27.1" "4.51" "76.27" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01086" "1211" "ENSG00000122705" "CLTA" "A8K4W3; B4DIN1; F5H6N3; hsa:1211; P09496; Q2XPN5; Q53XZ1" "Synaptic vesicle pathway; Ebola virus infection in host; Fragile X syndrome" "Recycling pathway of L1; MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Entry of Influenza Virion into Host Cell via Endocytosis; Formation of annular gap junctions" "17" "0" "0.980" "0.926" "0.947" "0.947" "0.963" "0.990" "1.028" "0.901" "0.366" "3175.4" "3113.2" "2940.8" "3006.3" "3006.1" "3057.3" "3142.1" "3262.7" "2861.7" "1161.8" "" "" "" "" "" "" "" "" "" "" "1900.3" "1617.8" "1628.6" "1411.4" "1393.4" "1565.1" "1461.0" "1464.8" "1552.6" "1161.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4600920651766906085" "False" "High" "IsMasterProtein" "O14602" "Eukaryotic translation initiation factor 1A, Y-chromosomal OS=Homo sapiens OX=9606 GN=EIF1AY PE=1 SV=4" "0.000" "False" "19.013" "26" "4" "8" "4" "144" "16.4" "5.24" "21.88" "4" "protein metabolism;other metabolic processes" "other cell component" "nucleic acid binding activity" "Pf01176" "9086" "ENSG00000198692" "EIF1AY" "hsa:9086; O14602; Q9BS77" "Translation factors" "" "1" "0" "1.038" "0.990" "0.879" "1.037" "1.026" "0.885" "1.054" "1.048" "0.613" "658.8" "684.1" "652.5" "578.8" "683.0" "675.6" "582.9" "694.5" "690.7" "403.9" "" "" "" "" "" "" "" "" "" "" "394.3" "355.5" "361.3" "271.7" "316.6" "345.9" "271.0" "311.8" "374.7" "403.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6701833234650983688" "False" "High" "IsMasterProtein" "O43865" "S-adenosylhomocysteine hydrolase-like protein 1 OS=Homo sapiens OX=9606 GN=AHCYL1 PE=1 SV=2" "0.000" "False" "18.987" "7" "6" "12" "3" "530" "58.9" "6.89" "29.22" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00670, Pf05221" "10768" "ENSG00000168710" "AHCYL1" "B4E168; hsa:10768; O43865; Q2TAJ6; Q502W8; Q5VSM0; Q6P171; Q96PK4; Q9UG84" "Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways" "Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Regulation of insulin secretion; VEGFR2 mediated cell proliferation; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation" "12" "1" "1.012" "0.838" "0.875" "0.941" "1.034" "0.906" "0.960" "1.039" "0.932" "508.1" "514.3" "425.8" "444.3" "478.2" "525.3" "460.5" "487.7" "527.7" "473.8" "" "" "" "" "" "" "" "" "" "" "304.0" "267.3" "235.8" "208.6" "221.7" "268.9" "214.1" "219.0" "286.3" "473.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3450396974392384393" "False" "High" "IsMasterProtein" "Q13112" "Chromatin assembly factor 1 subunit B OS=Homo sapiens OX=9606 GN=CHAF1B PE=1 SV=1" "0.000" "False" "18.987" "12" "6" "7" "6" "559" "61.5" "7.50" "18.62" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf00400, Pf15512" "8208" "ENSG00000159259" "CHAF1B" "hsa:8208; Q13112; Q99548" "" "" "0" "0" "1.058" "0.953" "1.026" "0.976" "0.950" "1.083" "1.056" "0.954" "0.597" "395.8" "418.7" "377.3" "405.9" "386.3" "375.9" "428.6" "417.8" "377.4" "236.1" "" "" "" "" "" "" "" "" "" "" "236.8" "217.6" "208.9" "190.6" "179.0" "192.4" "199.3" "187.5" "204.7" "236.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8199308046116639924" "False" "High" "IsMasterProtein" "Q29RF7" "Sister chromatid cohesion protein PDS5 homolog A OS=Homo sapiens OX=9606 GN=PDS5A PE=1 SV=1" "0.000" "False" "18.963" "5" "5" "5" "4" "1337" "150.7" "7.91" "16.88" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf20168" "23244" "ENSG00000121892" "PDS5A" "hsa:23244; Q29RF7; Q2TTR5; Q68DF7; Q8N7J4; Q8NG14; Q9Y4D4" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "6" "0" "1.235" "1.065" "1.116" "1.469" "1.407" "0.724" "1.156" "1.318" "4.198" "13.7" "16.9" "14.6" "15.3" "20.1" "19.3" "9.9" "15.8" "18.1" "57.5" "" "" "" "" "" "" "" "" "" "" "8.2" "8.8" "8.1" "7.2" "9.3" "9.9" "4.6" "7.1" "9.8" "57.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4468909642596951639" "False" "High" "IsMasterProtein" "Q15020" "Squamous cell carcinoma antigen recognized by T-cells 3 OS=Homo sapiens OX=9606 GN=SART3 PE=1 SV=1" "0.000" "False" "18.937" "5" "6" "8" "6" "963" "109.9" "5.57" "15.94" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf05391, Pf16605" "9733" "ENSG00000075856" "SART3" "A8K2E4; B7ZKM0; hsa:9733; Q15020; Q2M2H0; Q58F06; Q8IUS1; Q96J95" "" "" "0" "0" "1.072" "1.076" "1.015" "1.147" "1.108" "1.157" "0.616" "1.042" "7.440" "146.4" "156.9" "157.5" "148.5" "168.0" "162.2" "169.4" "90.2" "152.5" "1089.2" "" "" "" "" "" "" "" "" "" "" "87.6" "81.5" "87.2" "69.7" "77.9" "83.0" "78.8" "40.5" "82.7" "1089.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3289616204838975461" "False" "High" "IsMasterProtein" "P62851" "Small ribosomal subunit protein eS25 OS=Homo sapiens OX=9606 GN=RPS25 PE=1 SV=1" "0.000" "False" "18.916" "34" "5" "29" "5" "125" "13.7" "10.11" "70.40" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf03297" "6230" "ENSG00000118181; ENSG00000280831" "RPS25" "B2R4M7; hsa:6230; P25111; P62851" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.933" "0.862" "0.915" "1.075" "1.053" "1.001" "0.835" "0.875" "0.571" "1199.7" "1119.4" "1034.5" "1098.2" "1289.6" "1263.2" "1200.9" "1001.3" "1049.4" "685.0" "" "" "" "" "" "" "" "" "" "" "718.0" "581.7" "572.9" "515.6" "597.8" "646.7" "558.4" "449.5" "569.4" "685.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2821733550000515702" "False" "High" "IsMasterProtein" "Q9NX46" "ADP-ribosylhydrolase ARH3 OS=Homo sapiens OX=9606 GN=ADPRS PE=1 SV=1" "0.000" "False" "18.846" "17" "5" "8" "5" "363" "38.9" "5.07" "20.41" "5" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf03747" "54936" "ENSG00000116863" "ADPRS" "hsa:54936; Q53G94; Q6IAB8; Q9BY47; Q9NX46" "" "POLB-Dependent Long Patch Base Excision Repair" "1" "0" "1.002" "1.017" "1.114" "0.912" "1.103" "1.036" "1.025" "1.028" "1.232" "226.7" "227.2" "230.5" "252.5" "206.7" "250.0" "234.8" "232.4" "233.1" "279.2" "" "" "" "" "" "" "" "" "" "" "135.7" "118.1" "127.7" "118.5" "95.8" "128.0" "109.2" "104.3" "126.5" "279.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4002494153914850513" "False" "High" "IsMasterProtein" "P51665" "26S proteasome non-ATPase regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMD7 PE=1 SV=2" "0.000" "False" "18.819" "13" "4" "9" "4" "324" "37.0" "6.77" "30.92" "4" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01398, Pf13012" "5713" "ENSG00000103035" "PSMD7" "D3DWS9; hsa:5713; P51665; Q6PKI2; Q96E97" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "Downstream TCR signaling; Neutrophil degranulation; Orc1 removal from chromatin; Assembly of the pre-replicative complex; Separation of Sister Chromatids; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "1.054" "1.024" "1.112" "1.075" "1.123" "1.042" "1.069" "1.125" "0.723" "737.3" "777.3" "754.8" "819.6" "792.3" "828.0" "768.1" "788.3" "829.4" "533.1" "" "" "" "" "" "" "" "" "" "" "441.3" "404.0" "418.0" "384.8" "367.2" "423.9" "357.2" "353.9" "450.0" "533.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7707069974883679945" "False" "High" "IsMasterProtein" "P11836" "B-lymphocyte antigen CD20 OS=Homo sapiens OX=9606 GN=MS4A1 PE=1 SV=1" "0.000" "False" "18.809" "11" "3" "6" "3" "297" "33.1" "5.05" "16.22" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04103" "931" "ENSG00000156738" "MS4A1" "A6NMS4; B4DT24; hsa:931; P08984; P11836; Q13963" "Extrafollicular and follicular B cell activation by SARS-CoV-2; 11p11.2 copy number variation syndrome" "" "2" "0" "1.249" "1.197" "1.241" "1.050" "1.096" "1.117" "1.359" "1.297" "0.649" "232.7" "290.6" "278.5" "288.9" "244.4" "255.1" "259.9" "316.3" "301.8" "151.1" "" "" "" "" "" "" "" "" "" "" "139.3" "151.0" "154.2" "135.6" "113.3" "130.6" "120.9" "142.0" "163.7" "151.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7043086942307680796" "False" "High" "IsMasterProtein" "P63220" "Small ribosomal subunit protein eS21 OS=Homo sapiens OX=9606 GN=RPS21 PE=1 SV=1" "0.000" "False" "18.773" "49" "4" "10" "4" "83" "9.1" "8.50" "33.25" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01249" "6227" "ENSG00000171858" "RPS21" "hsa:6227; P35265; P63220" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "0.959" "1.050" "0.926" "0.941" "0.964" "0.926" "1.019" "0.971" "0.436" "1433.4" "1374.8" "1504.5" "1328.0" "1349.4" "1381.6" "1327.4" "1460.3" "1392.2" "624.4" "" "" "" "" "" "" "" "" "" "" "857.8" "714.4" "833.2" "623.4" "625.5" "707.3" "617.2" "655.6" "755.3" "624.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8925362845928829320" "False" "High" "IsMasterProtein" "Q12996" "Cleavage stimulation factor subunit 3 OS=Homo sapiens OX=9606 GN=CSTF3 PE=1 SV=1" "0.000" "False" "18.712" "7" "5" "7" "5" "717" "82.9" "8.12" "16.03" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf05843" "1479" "ENSG00000176102" "CSTF3" "A8K471; D3DR04; E9PB40; hsa:1479; Q12996; Q32P22; Q96FQ8; Q96QD6; Q96QK4" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.080" "1.020" "1.200" "1.106" "1.228" "1.098" "1.252" "1.031" "2.270" "192.5" "207.9" "196.3" "231.1" "212.8" "236.5" "211.3" "240.9" "198.5" "437.0" "" "" "" "" "" "" "" "" "" "" "115.2" "108.0" "108.7" "108.5" "98.6" "121.1" "98.2" "108.2" "107.7" "437.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8651766820472939276" "False" "High" "IsMasterProtein" "Q12792" "Twinfilin-1 OS=Homo sapiens OX=9606 GN=TWF1 PE=1 SV=3" "0.000" "False" "18.707" "17" "5" "5" "4" "350" "40.3" "6.96" "17.09" "5" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "5756" "ENSG00000151239" "TWF1" "A8K5A8; B3KXS6; B4DLX9; hsa:5756; Q12792; Q59G07; Q5U0B1; Q6FHJ1; Q6FHL6; Q6NUK9; Q86XL6; Q8TCD3" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHOBTB2 GTPase cycle" "3" "0" "1.011" "1.072" "1.091" "0.951" "0.990" "0.974" "1.063" "1.022" "0.708" "332.2" "335.9" "356.1" "362.4" "315.8" "328.8" "323.5" "353.1" "339.4" "235.2" "" "" "" "" "" "" "" "" "" "" "198.8" "174.6" "197.2" "170.1" "146.4" "168.3" "150.4" "158.5" "184.2" "235.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1603503262744250251" "False" "High" "IsMasterProtein" "P62805" "Histone H4 OS=Homo sapiens OX=9606 GN=H4C16 PE=1 SV=2" "0.000" "False" "18.685" "39" "4" "25" "4" "103" "11.4" "11.36" "62.15" "4" "cell organization and biogenesis;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15511" "121504; 554313; 8294; 8359; 8360; 8361; 8362; 8363; 8364; 8365; 8366; 8367; 8368; 8370" "ENSG00000158406; ENSG00000197061; ENSG00000197238; ENSG00000197837; ENSG00000270276; ENSG00000270882; ENSG00000273542; ENSG00000274618; ENSG00000275126; ENSG00000276180; ENSG00000276966; ENSG00000277157; ENSG00000278637; ENSG00000278705" "H4C1; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9" "A2VCL0; hsa:121504; hsa:554313; hsa:8294; hsa:8359; hsa:8360; hsa:8361; hsa:8362; hsa:8363; hsa:8364; hsa:8365; hsa:8366; hsa:8367; hsa:8368; hsa:8370; P02304; P02305; P62805; Q6DRA9; Q6FGB8; Q6NWP7" "Gastric cancer network 1; Histone modifications; 22q11.2 copy number variation syndrome; Male infertility; Type II interferon signaling" "Meiotic synapsis; Estrogen-dependent gene expression; HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Meiotic recombination; SUMOylation of chromatin organization proteins; HCMV Late Events; Amyloid fiber formation; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Early Events; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RMTs methylate histone arginines; HDMs demethylate histones; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; DNA methylation; Nonhomologous End-Joining (NHEJ); RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "52" "0" "0.866" "0.931" "0.899" "0.886" "0.962" "0.777" "0.767" "0.818" "0.845" "988.5" "855.8" "919.8" "888.8" "876.1" "950.9" "768.1" "757.7" "809.0" "835.6" "" "" "" "" "" "" "" "" "" "" "591.5" "444.7" "509.4" "417.3" "406.1" "486.8" "357.1" "340.2" "438.9" "835.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562361449972294003" "False" "High" "IsMasterProtein" "O00425" "Insulin-like growth factor 2 mRNA-binding protein 3 OS=Homo sapiens OX=9606 GN=IGF2BP3 PE=1 SV=2" "0.000" "False" "18.667" "13" "6" "6" "6" "579" "63.7" "8.87" "16.87" "6" "protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00076" "10643" "ENSG00000136231" "IGF2BP3" "A0A4Z5; hsa:10643; O00425; Q63HM0; Q6MZZ2; Q86VB1" "" "Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA" "1" "0" "0.940" "0.905" "1.175" "1.088" "1.033" "1.063" "0.690" "1.055" "5.031" "234.6" "220.6" "212.2" "275.7" "255.3" "242.4" "249.3" "161.8" "247.5" "1180.0" "" "" "" "" "" "" "" "" "" "" "140.4" "114.6" "117.5" "129.4" "118.3" "124.1" "115.9" "72.7" "134.3" "1180.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2758380383998066899" "False" "High" "IsMasterProtein" "Q86V81" "THO complex subunit 4 OS=Homo sapiens OX=9606 GN=ALYREF PE=1 SV=3" "0.000" "False" "18.660" "22" "5" "16" "5" "257" "26.9" "11.15" "41.79" "5" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf13865" "10189" "" "ALYREF" "hsa:10189; O43672; Q86V81" "" "mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript" "7" "0" "0.907" "0.887" "0.923" "0.933" "0.875" "0.915" "0.931" "0.845" "0.498" "410.2" "372.1" "363.9" "378.5" "382.7" "359.0" "375.5" "382.0" "346.5" "204.2" "" "" "" "" "" "" "" "" "" "" "245.5" "193.3" "201.5" "177.7" "177.4" "183.8" "174.6" "171.5" "188.0" "204.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1699375806796057255" "False" "High" "IsMasterProtein" "Q6IA69" "Glutamine-dependent NAD(+) synthetase OS=Homo sapiens OX=9606 GN=NADSYN1 PE=1 SV=3" "0.000" "False" "18.643" "9" "5" "8" "5" "706" "79.2" "6.44" "23.73" "5" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00795, Pf02540" "55191" "ENSG00000172890" "NADSYN1" "B3KUU4; hsa:55191; Q6IA69; Q86SN2; Q9HA25; Q9NVM8" "NAD biosynthesis II (from tryptophan); NAD+ biosynthetic pathways" "Nicotinate metabolism" "3" "0" "0.919" "0.840" "0.972" "0.933" "1.028" "1.048" "0.838" "0.894" "0.812" "196.2" "180.3" "164.8" "190.7" "183.0" "201.7" "205.6" "164.5" "175.3" "159.3" "" "" "" "" "" "" "" "" "" "" "117.4" "93.7" "91.3" "89.5" "84.8" "103.3" "95.6" "73.9" "95.1" "159.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "636638520442762569" "False" "High" "IsMasterProtein" "P54725" "UV excision repair protein RAD23 homolog A OS=Homo sapiens OX=9606 GN=RAD23A PE=1 SV=1" "0.000" "False" "18.574" "17" "5" "22" "4" "363" "39.6" "4.58" "45.98" "5" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00627, Pf09280" "5886" "ENSG00000179262" "RAD23A" "hsa:5886; K7ESE3; P54725; Q59EU8; Q5M7Z1" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Josephin domain DUBs; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "6" "0" "1.004" "1.054" "1.124" "1.203" "1.312" "1.220" "1.214" "1.131" "0.824" "116.3" "116.8" "122.6" "130.7" "140.0" "152.6" "141.9" "141.2" "131.6" "95.8" "" "" "" "" "" "" "" "" "" "" "69.6" "60.7" "67.9" "61.4" "64.9" "78.1" "66.0" "63.4" "71.4" "95.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5104868076877432039" "False" "High" "IsMasterProtein" "Q9HC38" "Glyoxalase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GLOD4 PE=1 SV=1" "0.000" "False" "18.569" "17" "5" "6" "5" "313" "34.8" "5.60" "16.12" "5" "" "mitochondrion" "" "Pf21207, Pf21701" "51031" "ENSG00000167699" "GLOD4" "D3DTG9; D3DTH1; hsa:51031; Q96B89; Q9H3J8; Q9HC37; Q9HC38; Q9NVN1" "" "" "0" "0" "1.015" "1.288" "1.045" "1.013" "0.955" "0.971" "0.848" "1.008" "3.948" "258.2" "262.1" "332.7" "269.8" "261.5" "246.7" "250.7" "219.0" "260.3" "1019.3" "" "" "" "" "" "" "" "" "" "" "154.5" "136.2" "184.2" "126.7" "121.2" "126.3" "116.5" "98.3" "141.2" "1019.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3220884936245267041" "False" "High" "IsMasterProtein" "Q8WUA7" "TBC1 domain family member 22A OS=Homo sapiens OX=9606 GN=TBC1D22A PE=1 SV=2" "0.000" "False" "18.516" "10" "4" "6" "4" "517" "59.1" "5.97" "20.05" "4" "" "" "enzyme regulator activity;other molecular function" "Pf00566" "25771" "ENSG00000054611" "TBC1D22A" "B0QYI2; B0QYI3; B9A6M3; hsa:25771; Q5TE47; Q6ZUH2; Q8WUA7; Q92680; Q9BVD6; Q9UGG0; Q9UGT2; Q9UGU6; Q9UH25; Q9Y4W5" "" "" "0" "0" "0.816" "0.924" "1.027" "0.975" "1.062" "0.939" "1.093" "1.106" "0.669" "247.0" "201.5" "228.2" "253.7" "240.8" "262.4" "231.9" "270.1" "273.1" "165.2" "" "" "" "" "" "" "" "" "" "" "147.8" "104.7" "126.4" "119.1" "111.6" "134.3" "107.8" "121.3" "148.2" "165.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6825792350743248999" "False" "High" "IsMasterProtein" "P07738" "Bisphosphoglycerate mutase OS=Homo sapiens OX=9606 GN=BPGM PE=1 SV=2" "0.000" "False" "18.471" "29" "6" "7" "6" "259" "30.0" "6.54" "18.23" "6" "other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00300" "669" "ENSG00000172331" "BPGM" "A4D1N9; hsa:669; P07738" "IL-18 signaling pathway" "Glycolysis" "2" "0" "0.940" "0.995" "1.176" "1.078" "0.871" "1.015" "1.069" "1.044" "0.626" "167.2" "157.2" "166.5" "196.7" "180.3" "145.6" "169.7" "178.8" "174.6" "104.6" "" "" "" "" "" "" "" "" "" "" "100.1" "81.7" "92.2" "92.3" "83.6" "74.6" "78.9" "80.3" "94.7" "104.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6610589870849209696" "False" "High" "IsMasterProtein" "Q9NZ63" "Splicing factor C9orf78 OS=Homo sapiens OX=9606 GN=C9orf78 PE=1 SV=1" "0.000" "False" "18.471" "14" "4" "7" "4" "289" "33.7" "6.74" "18.26" "4" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf07052" "51759" "ENSG00000136819" "C9orf78" "B3KPX8; Q8WVU6; Q9NT39; Q9NZ63" "" "mRNA Splicing - Major Pathway" "1" "0" "0.957" "0.884" "0.859" "0.906" "0.904" "0.899" "1.064" "0.865" "0.382" "1088.1" "1041.3" "961.7" "934.5" "985.6" "983.4" "978.0" "1158.2" "941.8" "416.0" "" "" "" "" "" "" "" "" "" "" "651.2" "541.1" "532.6" "438.7" "456.9" "503.4" "454.7" "520.0" "510.9" "416.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "240711896831941506" "False" "High" "IsMasterProtein" "P23396" "Small ribosomal subunit protein uS3 OS=Homo sapiens OX=9606 GN=RPS3 PE=1 SV=2" "0.000" "False" "18.436" "21" "5" "19" "5" "243" "26.7" "9.66" "45.54" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00189, Pf07650" "6188" "ENSG00000149273" "RPS3" "B2R7N5; hsa:6188; J3KN86; P23396; Q498B5; Q8NI95" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.001" "1.020" "1.128" "1.059" "1.073" "1.042" "0.891" "1.023" "2.705" "1014.0" "1014.9" "1034.2" "1143.5" "1073.4" "1087.6" "1056.3" "903.1" "1037.7" "2742.3" "" "" "" "" "" "" "" "" "" "" "606.8" "527.4" "572.7" "536.8" "497.6" "556.8" "491.2" "405.5" "563.0" "2742.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6400995593712089390" "False" "High" "IsMasterProtein" "Q9NYU2" "UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3" "0.000" "False" "18.426" "3" "6" "7" "6" "1555" "177.1" "5.63" "17.92" "6" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf06427, Pf18400, Pf18401, Pf18402, Pf18403, Pf18404" "56886" "ENSG00000136731" "UGGT1" "hsa:56886; Q53QP2; Q53SL3; Q8IW30; Q9H8I4; Q9NYU2" "IL-18 signaling pathway" "ER Quality Control Compartment (ERQC)" "2" "0" "0.931" "0.941" "1.168" "1.158" "1.200" "1.088" "0.972" "0.972" "2.277" "150.0" "139.6" "141.2" "175.2" "173.6" "180.0" "163.2" "145.7" "145.7" "341.5" "" "" "" "" "" "" "" "" "" "" "89.7" "72.5" "78.2" "82.3" "80.5" "92.1" "75.9" "65.4" "79.1" "341.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2928934229844812076" "False" "High" "IsMasterProtein" "Q8TCD5" "5'(3')-deoxyribonucleotidase, cytosolic type OS=Homo sapiens OX=9606 GN=NT5C PE=1 SV=2" "0.000" "False" "18.404" "21" "5" "7" "5" "201" "23.4" "6.64" "21.49" "5" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06941" "30833" "ENSG00000125458" "NT5C" "hsa:30833; Q8TCD5; Q96HS6; Q9NP82" "Pyrimidine metabolism" "Purine catabolism; Pyrimidine catabolism" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8809117759024256443" "False" "High" "IsMasterProtein" "P29692" "Elongation factor 1-delta OS=Homo sapiens OX=9606 GN=EEF1D PE=1 SV=5" "0.000" "False" "18.375" "19" "3" "5" "3" "281" "31.1" "5.01" "18.87" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00736, Pf10587" "1936" "ENSG00000104529; ENSG00000273594" "EEF1D" "B4DDU4; D3DWK3; E9PBQ9; hsa:1936; P29692; Q4VBZ6; Q969J1; Q96I38" "Translation factors" "Eukaryotic Translation Elongation" "2" "0" "0.968" "1.304" "1.154" "0.917" "1.049" "1.037" "0.837" "1.021" "3.904" "93.0" "90.0" "121.4" "107.4" "85.4" "97.6" "96.5" "77.9" "95.0" "363.2" "" "" "" "" "" "" "" "" "" "" "55.7" "46.8" "67.2" "50.4" "39.6" "50.0" "44.9" "35.0" "51.6" "363.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7990537509462567326" "False" "High" "IsMasterProtein" "P16298" "Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PPP3CB PE=1 SV=2" "0.000" "False" "18.362" "9" "5" "14" "1" "524" "59.0" "5.91" "35.39" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00149" "5532" "ENSG00000107758" "PPP3CB" "hsa:5532; P16298; P16299; Q5F2F9; Q8N1F0; Q8N3W4" "Physiological and pathological hypertrophy of the heart; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Amyotrophic lateral sclerosis (ALS); Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; Wnt signaling; Alzheimer's disease; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; DARPP-32 events; ROBO receptors bind AKAP5" "16" "0" "1.193" "1.037" "1.028" "1.182" "1.285" "0.917" "1.087" "1.223" "1.428" "45.9" "54.8" "47.6" "47.2" "54.3" "59.0" "42.1" "49.9" "56.1" "65.6" "" "" "" "" "" "" "" "" "" "" "27.5" "28.5" "26.4" "22.2" "25.2" "30.2" "19.6" "22.4" "30.5" "65.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5490413544944086937" "False" "High" "IsMasterProtein" "Q9BPX5" "Actin-related protein 2/3 complex subunit 5-like protein OS=Homo sapiens OX=9606 GN=ARPC5L PE=1 SV=1" "0.000" "False" "18.354" "23" "3" "15" "3" "153" "16.9" "6.60" "43.04" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf04699" "81873" "ENSG00000136950" "ARPC5L" "hsa:81873; Q7Z523; Q9BPX5" "Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling" "" "2" "0" "0.940" "0.978" "1.119" "1.092" "0.959" "1.197" "1.020" "1.029" "0.775" "445.5" "418.7" "435.9" "498.4" "486.7" "427.3" "533.2" "454.7" "458.6" "345.2" "" "" "" "" "" "" "" "" "" "" "266.6" "217.6" "241.4" "234.0" "225.6" "218.8" "247.9" "204.1" "248.8" "345.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1575206036117319314" "False" "High" "IsMasterProtein" "Q9Y608" "Leucine-rich repeat flightless-interacting protein 2 OS=Homo sapiens OX=9606 GN=LRRFIP2 PE=1 SV=1" "0.000" "False" "18.343" "7" "5" "5" "4" "721" "82.1" "6.95" "17.52" "5" "cell-cell signaling;signal transduction;other biological processes" "" "other molecular function" "Pf09738" "9209" "ENSG00000093167" "LRRFIP2" "A8K649; A8MXR0; B4DY63; Q68CV3; Q9NXH5; Q9Y608" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.148" "1.063" "0.971" "1.094" "1.217" "1.048" "1.103" "1.171" "0.678" "268.1" "307.8" "285.1" "260.4" "293.4" "326.2" "280.9" "295.7" "314.0" "181.7" "" "" "" "" "" "" "" "" "" "" "160.4" "160.0" "157.9" "122.2" "136.0" "167.0" "130.6" "132.8" "170.3" "181.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1764632123327779223" "False" "High" "IsMasterProtein" "P46060" "Ran GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RANGAP1 PE=1 SV=1" "0.000" "False" "18.334" "8" "5" "8" "5" "587" "63.5" "4.68" "21.69" "5" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf07834, Pf13516" "5905" "ENSG00000100401" "RANGAP1" "hsa:5905; P46060; Q96JJ2" "22q11.2 copy number variation syndrome; IL-18 signaling pathway" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Rev-mediated nuclear export of HIV RNA; SUMOylation of DNA replication proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of nuclear envelope proteins" "12" "0" "1.127" "1.098" "1.219" "1.349" "1.107" "1.212" "0.656" "1.080" "6.251" "225.2" "253.7" "247.2" "274.5" "303.8" "249.3" "273.0" "147.6" "243.1" "1407.6" "" "" "" "" "" "" "" "" "" "" "134.7" "131.8" "136.9" "128.9" "140.8" "127.6" "126.9" "66.3" "131.9" "1407.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5953183427719841951" "False" "High" "IsMasterProtein" "P18615" "Negative elongation factor E OS=Homo sapiens OX=9606 GN=NELFE PE=1 SV=3" "0.000" "False" "18.297" "11" "4" "5" "4" "380" "43.2" "9.33" "12.47" "4" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "7936" "ENSG00000204356; ENSG00000206268; ENSG00000206357; ENSG00000229363; ENSG00000231044; ENSG00000233801" "NELFE" "A2BE08; B4DUN1; B4DYX9; hsa:7936; P18615; Q5JP74; Q5JP75; Q96F56; Q9NPK2" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "16" "0" "1.187" "1.027" "0.980" "1.166" "1.113" "1.078" "0.953" "1.076" "1.185" "126.4" "150.1" "129.9" "123.9" "147.4" "140.7" "136.2" "120.5" "136.1" "149.8" "" "" "" "" "" "" "" "" "" "" "75.7" "78.0" "71.9" "58.2" "68.3" "72.0" "63.3" "54.1" "73.8" "149.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3006741669515463279" "False" "High" "IsMasterProtein" "Q8WUD1" "Ras-related protein Rab-2B OS=Homo sapiens OX=9606 GN=RAB2B PE=1 SV=1" "0.000" "False" "18.289" "15" "3" "10" "3" "216" "24.2" "7.83" "31.26" "3" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00071" "84932" "ENSG00000129472" "RAB2B" "B2RD03; D3DS24; hsa:84932; Q6NZ33; Q8WUD1" "" "RAB geranylgeranylation" "1" "0" "0.922" "0.980" "0.921" "0.902" "1.012" "0.867" "1.029" "0.944" "0.721" "617.1" "569.0" "604.5" "568.4" "556.5" "624.7" "534.8" "634.7" "582.6" "444.9" "" "" "" "" "" "" "" "" "" "" "369.3" "295.7" "334.8" "266.9" "257.9" "319.8" "248.7" "285.0" "316.1" "444.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3146791204946970239" "False" "High" "IsMasterProtein" "Q9Y6W5" "Actin-binding protein WASF2 OS=Homo sapiens OX=9606 GN=WASF2 PE=1 SV=3" "0.000" "False" "18.259" "8" "4" "9" "4" "498" "54.3" "5.53" "24.81" "4" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "10163" "ENSG00000158195" "WASF2" "B4DZN0; hsa:10163; O60794; Q9UDY7; Q9Y6W5" "Regulation of actin cytoskeleton" "Regulation of actin dynamics for phagocytic cup formation; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway" "8" "0" "1.206" "1.097" "1.189" "1.188" "1.063" "1.143" "1.191" "1.126" "1.191" "513.1" "618.7" "563.1" "609.9" "609.8" "545.3" "586.6" "611.2" "577.8" "611.4" "" "" "" "" "" "" "" "" "" "" "307.1" "321.5" "311.8" "286.3" "282.7" "279.2" "272.7" "274.4" "313.5" "611.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-902532758451743562" "False" "High" "IsMasterProtein" "Q96B26" "Exosome complex component RRP43 OS=Homo sapiens OX=9606 GN=EXOSC8 PE=1 SV=1" "0.000" "False" "18.205" "21" "4" "6" "4" "276" "30.0" "5.30" "9.62" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "11340" "ENSG00000120699" "EXOSC8" "hsa:11340; O43480; Q5TBA5; Q96B26" "" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "1.045" "1.026" "1.079" "0.951" "1.216" "0.933" "0.961" "1.164" "0.562" "142.5" "148.9" "146.1" "153.7" "135.5" "173.3" "132.9" "136.9" "165.8" "80.1" "" "" "" "" "" "" "" "" "" "" "85.3" "77.4" "80.9" "72.1" "62.8" "88.7" "61.8" "61.5" "89.9" "80.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8205136122998856932" "False" "High" "IsMasterProtein" "P60981" "Destrin OS=Homo sapiens OX=9606 GN=DSTN PE=1 SV=3" "0.000" "False" "18.186" "24" "4" "7" "3" "165" "18.5" "7.85" "21.59" "4" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf00241" "11034" "ENSG00000125868" "DSTN" "B2R6N2; B4DYA6; hsa:11034; P18282; P60981; Q5W166; Q6IAW2" "Androgen receptor signaling pathway" "" "1" "0" "0.734" "1.143" "0.843" "1.022" "0.952" "0.866" "0.918" "0.853" "0.830" "67.3" "49.4" "76.9" "56.7" "68.7" "64.1" "58.2" "61.7" "57.4" "55.8" "" "" "" "" "" "" "" "" "" "" "40.2" "25.7" "42.6" "26.6" "31.9" "32.8" "27.1" "27.7" "31.1" "55.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-558081350695480590" "False" "High" "IsMasterProtein" "O43172" "U4/U6 small nuclear ribonucleoprotein Prp4 OS=Homo sapiens OX=9606 GN=PRPF4 PE=1 SV=2" "0.000" "False" "18.112" "10" "5" "6" "5" "522" "58.4" "7.42" "11.90" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00400, Pf08799" "9128" "ENSG00000136875" "PRPF4" "hsa:9128; O43172; O43445; O43864; Q5T1M8; Q96DG2; Q96IK4" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.994" "1.113" "1.097" "1.204" "1.098" "1.053" "0.875" "1.086" "2.532" "131.4" "130.6" "146.3" "144.2" "158.2" "144.3" "138.5" "115.0" "142.8" "332.8" "" "" "" "" "" "" "" "" "" "" "78.7" "67.9" "81.0" "67.7" "73.3" "73.9" "64.4" "51.6" "77.5" "332.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5067244968494119358" "False" "High" "IsMasterProtein" "O75496" "Geminin OS=Homo sapiens OX=9606 GN=GMNN PE=1 SV=1" "0.000" "False" "18.105" "25" "4" "10" "4" "209" "23.6" "4.96" "30.67" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07412" "51053" "ENSG00000112312" "GMNN" "B3KMM8; hsa:51053; O75496; Q9H1Z1" "DNA replication; DYRK1A involvement regarding cell proliferation in brain development" "Assembly of the pre-replicative complex; Activation of the pre-replicative complex; Switching of origins to a post-replicative state" "5" "0" "0.957" "1.052" "0.961" "1.101" "1.132" "1.694" "1.796" "1.576" "0.695" "637.2" "609.6" "670.6" "612.6" "701.8" "721.0" "1079.6" "1144.3" "1004.4" "443.1" "" "" "" "" "" "" "" "" "" "" "381.3" "316.8" "371.4" "287.6" "325.3" "369.1" "502.0" "513.7" "544.9" "443.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8330278091767700695" "False" "High" "IsMasterProtein" "Q6PCB5" "Lysine-specific demethylase RSBN1L OS=Homo sapiens OX=9606 GN=RSBN1L PE=1 SV=2" "0.000" "False" "18.100" "7" "6" "11" "6" "846" "94.8" "8.78" "22.83" "6" "" "nucleus" "other molecular function" "" "222194" "ENSG00000187257" "RSBN1L" "C9K0P1; hsa:222194; Q6PCB5; Q6ZS58; Q6ZVI9; Q86X48" "" "" "0" "0" "0.916" "0.972" "1.003" "1.114" "0.876" "1.057" "1.014" "0.955" "0.816" "187.3" "171.6" "182.1" "187.9" "208.7" "164.0" "197.9" "190.0" "178.8" "152.9" "" "" "" "" "" "" "" "" "" "" "112.1" "89.2" "100.8" "88.2" "96.7" "84.0" "92.0" "85.3" "97.0" "152.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6612546022737726869" "False" "High" "IsMasterProtein" "P80303" "Nucleobindin-2 OS=Homo sapiens OX=9606 GN=NUCB2 PE=1 SV=3" "0.000" "False" "18.097" "15" "6" "9" "6" "420" "50.2" "5.12" "19.11" "6" "signal transduction" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf13499" "4925" "ENSG00000070081" "NUCB2" "A8K642; D3DQX5; hsa:4925; P80303; Q8NFT5; V9HW75" "" "" "0" "0" "1.082" "0.878" "0.903" "1.013" "1.019" "1.095" "1.197" "1.103" "0.535" "384.4" "415.9" "337.6" "346.9" "389.5" "391.6" "420.8" "460.0" "424.0" "205.8" "" "" "" "" "" "" "" "" "" "" "230.0" "216.1" "187.0" "162.9" "180.5" "200.5" "195.7" "206.5" "230.0" "205.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7652533075202528091" "False" "High" "IsMasterProtein" "Q92734" "Protein TFG OS=Homo sapiens OX=9606 GN=TFG PE=1 SV=2" "0.000" "False" "18.068" "15" "4" "6" "4" "400" "43.4" "5.10" "19.33" "4" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00564" "10342" "ENSG00000114354" "TFG" "D3DN49; G5E9V1; hsa:10342; K0J5S8; K0J6K2; Q15656; Q92734; Q969I2" "" "Signaling by ALK fusions and activated point mutants; COPII-mediated vesicle transport" "2" "0" "1.016" "0.911" "0.970" "1.197" "0.955" "1.021" "1.191" "1.128" "0.565" "330.7" "336.0" "301.2" "320.7" "395.9" "315.9" "337.7" "393.8" "373.0" "187.0" "" "" "" "" "" "" "" "" "" "" "197.9" "174.6" "166.8" "150.6" "183.5" "161.7" "157.0" "176.8" "202.4" "187.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5749593247568362596" "False" "High" "IsMasterProtein" "Q9NYV4" "Cyclin-dependent kinase 12 OS=Homo sapiens OX=9606 GN=CDK12 PE=1 SV=2" "0.000" "False" "18.052" "4" "4" "6" "3" "1490" "164.1" "9.44" "20.48" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "51755" "ENSG00000167258" "CDK12" "A7E2B2; B4DYX4; B9EIQ6; hsa:51755; O94978; Q9NYV4" "17q12 copy number variation syndrome" "TP53 Regulates Transcription of DNA Repair Genes" "2" "0" "1.056" "0.987" "0.795" "0.968" "1.189" "1.073" "1.270" "1.207" "0.649" "88.2" "93.2" "87.1" "70.2" "85.4" "105.0" "94.7" "112.1" "106.5" "57.3" "" "" "" "" "" "" "" "" "" "" "52.8" "48.4" "48.2" "32.9" "39.6" "53.7" "44.0" "50.3" "57.8" "57.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3614438977501336635" "False" "High" "IsMasterProtein" "Q92558" "Actin-binding protein WASF1 OS=Homo sapiens OX=9606 GN=WASF1 PE=1 SV=1" "0.000" "False" "18.039" "8" "5" "8" "5" "559" "61.6" "6.46" "22.10" "5" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "8936" "ENSG00000112290" "WASF1" "E1P5F2; hsa:8936; Q5SZK7; Q92558" "VEGFA-VEGFR2 signaling; Regulation of actin cytoskeleton" "RAC1 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "8" "0" "1.181" "1.238" "1.380" "1.388" "1.233" "1.224" "1.430" "1.349" "1.545" "159.9" "188.8" "197.9" "220.6" "221.9" "197.2" "195.7" "228.7" "215.7" "247.1" "" "" "" "" "" "" "" "" "" "" "95.7" "98.1" "109.6" "103.6" "102.8" "101.0" "91.0" "102.7" "117.0" "247.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1351774447437735542" "False" "High" "IsMasterProtein" "Q9NQW7" "Xaa-Pro aminopeptidase 1 OS=Homo sapiens OX=9606 GN=XPNPEP1 PE=1 SV=3" "0.000" "False" "18.026" "8" "6" "13" "6" "623" "69.9" "5.67" "24.00" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00557, Pf01321, Pf16188, Pf16189" "7511" "ENSG00000108039" "XPNPEP1" "A8K071; G5E9Y2; G8JLB2; hsa:7511; O15250; Q53EX6; Q8N3Q0; Q96D23; Q9NQW7" "" "" "0" "0" "0.946" "0.879" "1.048" "0.970" "0.944" "1.002" "0.870" "0.911" "1.668" "444.5" "420.4" "390.6" "465.7" "431.3" "419.5" "445.4" "386.6" "404.8" "741.2" "" "" "" "" "" "" "" "" "" "" "266.0" "218.4" "216.3" "218.6" "199.9" "214.8" "207.1" "173.6" "219.6" "741.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6467566476375476721" "False" "High" "IsMasterProtein" "Q03154" "Aminoacylase-1 OS=Homo sapiens OX=9606 GN=ACY1 PE=1 SV=1" "0.000" "False" "18.014" "14" "5" "5" "5" "408" "45.9" "6.18" "16.64" "5" "other metabolic processes" "non-structural extracellular;cytosol" "other molecular function" "Pf01546, Pf07687" "95" "ENSG00000243989" "ACY1" "C9J6I6; C9J9D8; C9JWD4; hsa:95; Q03154" "Thyroxine (thyroid hormone) production" "Aflatoxin activation and detoxification; Paracetamol ADME; Defective ACY1 causes encephalopathy" "4" "0" "0.925" "1.090" "1.012" "1.187" "1.040" "1.154" "1.038" "1.156" "0.811" "263.1" "243.4" "286.7" "266.2" "312.4" "273.6" "303.6" "273.1" "304.1" "213.4" "" "" "" "" "" "" "" "" "" "" "157.4" "126.5" "158.8" "125.0" "144.8" "140.1" "141.2" "122.6" "165.0" "213.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "291264612704325176" "False" "High" "IsMasterProtein" "Q13685" "Angio-associated migratory cell protein OS=Homo sapiens OX=9606 GN=AAMP PE=1 SV=2" "0.000" "False" "17.994" "11" "5" "7" "5" "434" "46.7" "4.42" "22.27" "5" "developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00400" "14" "ENSG00000127837" "AAMP" "hsa:14; Q13685; Q8WUJ9; Q96H92" "Nucleotide-binding oligomerization domain (NOD) pathway" "Thromboxane signalling through TP receptor; Signaling by EGFR; NOD1/2 Signaling Pathway; Signaling by VEGF" "5" "0" "1.099" "1.040" "1.141" "1.085" "1.103" "1.075" "1.078" "1.203" "1.140" "414.1" "455.2" "430.8" "472.6" "449.4" "456.9" "445.3" "446.3" "498.2" "471.9" "" "" "" "" "" "" "" "" "" "" "247.8" "236.5" "238.6" "221.9" "208.3" "233.9" "207.0" "200.4" "270.3" "471.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5608231469546375684" "False" "High" "IsMasterProtein" "O00161" "Synaptosomal-associated protein 23 OS=Homo sapiens OX=9606 GN=SNAP23 PE=1 SV=1" "0.000" "False" "17.979" "21" "4" "5" "4" "211" "23.3" "5.01" "15.73" "4" "cell-cell signaling;cell organization and biogenesis;stress response;transport" "plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00835" "8773" "ENSG00000092531" "SNAP23" "hsa:8773; O00161; O00162; Q13602; Q6IAE3" "Insulin signaling" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; ER-Phagosome pathway; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; trans-Golgi Network Vesicle Budding" "13" "0" "0.966" "0.874" "1.076" "0.941" "1.040" "1.149" "1.133" "1.059" "0.572" "299.6" "289.3" "261.9" "322.3" "281.8" "311.5" "344.4" "339.6" "317.4" "171.5" "" "" "" "" "" "" "" "" "" "" "179.3" "150.4" "145.0" "151.3" "130.6" "159.5" "160.1" "152.4" "172.2" "171.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2819715853452011200" "False" "High" "IsMasterProtein" "Q8WUD4" "Coiled-coil domain-containing protein 12 OS=Homo sapiens OX=9606 GN=CCDC12 PE=1 SV=1" "0.000" "False" "17.898" "31" "5" "9" "5" "166" "19.2" "7.34" "24.41" "5" "" "nucleus" "" "Pf08315" "151903" "ENSG00000160799" "CCDC12" "hsa:151903; Q8N8I4; Q8WUD4" "" "mRNA Splicing - Major Pathway" "1" "0" "1.127" "1.120" "1.029" "1.192" "0.940" "1.153" "1.064" "0.942" "0.416" "230.3" "259.6" "257.9" "237.0" "274.4" "216.5" "265.5" "245.0" "216.9" "95.8" "" "" "" "" "" "" "" "" "" "" "137.8" "134.9" "142.8" "111.3" "127.2" "110.8" "123.4" "110.0" "117.7" "95.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-507762156530799771" "False" "High" "IsMasterProtein" "O43670" "BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1" "0.000" "False" "17.885" "7" "3" "15" "3" "478" "50.7" "9.10" "38.88" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "" "7756" "ENSG00000010244" "ZNF207" "A8K6Y6; E1P660; E1P661; E1P662; hsa:7756; O43670; Q53XS9; Q96HW5; Q9BUQ7" "" "" "0" "0" "1.045" "1.079" "1.122" "1.122" "1.064" "1.073" "1.184" "1.097" "0.627" "579.2" "605.0" "624.8" "649.8" "649.8" "616.3" "621.6" "685.6" "635.1" "363.4" "" "" "" "" "" "" "" "" "" "" "346.6" "314.4" "346.0" "305.1" "301.2" "315.5" "289.0" "307.8" "344.6" "363.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7946497630754715310" "False" "High" "IsMasterProtein" "Q9H223" "EH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=EHD4 PE=1 SV=1" "0.000" "False" "17.876" "10" "5" "6" "5" "541" "61.1" "6.76" "12.77" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00350, Pf12763, Pf16880, Pf18150" "30844" "ENSG00000103966" "EHD4" "hsa:30844; Q9H223; Q9HAR1; Q9NZN2" "" "" "0" "0" "1.100" "0.984" "1.131" "0.968" "1.201" "1.252" "1.070" "1.134" "3.659" "131.9" "145.1" "129.8" "149.2" "127.7" "158.5" "165.2" "141.1" "149.6" "482.7" "" "" "" "" "" "" "" "" "" "" "78.9" "75.4" "71.9" "70.1" "59.2" "81.1" "76.8" "63.4" "81.1" "482.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "454806171855366482" "False" "High" "IsMasterProtein" "P40939" "Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=HADHA PE=1 SV=2" "0.000" "False" "17.862" "8" "6" "7" "6" "763" "82.9" "9.04" "15.66" "6" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00378, Pf00725, Pf02737" "3030" "ENSG00000084754" "HADHA" "B2R7L4; B4DYP2; hsa:3030; P40939; Q16679; Q53T69; Q53TA2; Q96GT7; Q9UQC5" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Valproic acid pathway; Mitochondrial fatty acid oxidation disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "Acyl chain remodeling of CL; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "13" "0" "1.111" "1.068" "1.350" "1.088" "1.118" "1.143" "1.130" "0.971" "7.253" "29.5" "32.8" "31.5" "39.8" "32.1" "33.0" "33.7" "33.3" "28.7" "214.1" "" "" "" "" "" "" "" "" "" "" "17.7" "17.0" "17.5" "18.7" "14.9" "16.9" "15.7" "15.0" "15.5" "214.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6501697818920195355" "False" "High" "IsMasterProtein" "Q9Y3B9" "RRP15-like protein OS=Homo sapiens OX=9606 GN=RRP15 PE=1 SV=2" "0.000" "False" "17.795" "20" "4" "11" "4" "282" "31.5" "5.52" "29.74" "4" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "" "Pf07890" "51018" "ENSG00000067533" "RRP15" "hsa:51018; Q9Y3B9" "" "" "0" "0" "1.004" "0.942" "1.030" "1.139" "1.076" "1.081" "1.080" "0.998" "0.384" "780.8" "783.8" "735.2" "804.5" "889.1" "840.3" "844.3" "843.1" "778.8" "300.0" "" "" "" "" "" "" "" "" "" "" "467.3" "407.3" "407.1" "377.7" "412.1" "430.2" "392.6" "378.5" "422.6" "300.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7690147936594120282" "False" "High" "IsMasterProtein" "P08397" "Porphobilinogen deaminase OS=Homo sapiens OX=9606 GN=HMBS PE=1 SV=2" "0.000" "False" "17.760" "11" "4" "11" "4" "361" "39.3" "7.18" "21.70" "4" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01379, Pf03900" "3145" "ENSG00000256269" "HMBS" "A8K2L0; G3V1P4; G5EA58; hsa:3145; P08396; P08397; Q16012" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "3" "0" "0.948" "1.016" "1.014" "0.995" "1.068" "0.962" "1.138" "0.991" "0.617" "544.0" "515.9" "552.7" "551.4" "541.4" "581.0" "523.4" "619.3" "538.9" "335.7" "" "" "" "" "" "" "" "" "" "" "325.6" "268.1" "306.1" "258.9" "250.9" "297.4" "243.4" "278.0" "292.4" "335.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5373690399274413822" "False" "High" "IsMasterProtein" "Q8N543" "Prolyl 3-hydroxylase OGFOD1 OS=Homo sapiens OX=9606 GN=OGFOD1 PE=1 SV=1" "0.000" "False" "17.754" "12" "6" "8" "6" "542" "63.2" "5.11" "16.77" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf10637, Pf13661" "55239" "ENSG00000087263" "OGFOD1" "H3BUQ2; hsa:55239; Q8N543; Q9H7U5; Q9H9J9; Q9HA87; Q9HCG0; Q9NVB6" "" "Protein hydroxylation" "1" "0" "1.067" "0.973" "0.942" "1.242" "0.998" "1.178" "1.028" "1.216" "1.146" "354.2" "378.1" "344.8" "333.7" "440.0" "353.4" "417.1" "364.0" "430.8" "405.9" "" "" "" "" "" "" "" "" "" "" "212.0" "196.5" "190.9" "156.6" "203.9" "180.9" "194.0" "163.4" "233.7" "405.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5999519850232784779" "False" "High" "IsMasterProtein" "Q9Y3L3" "SH3 domain-binding protein 1 OS=Homo sapiens OX=9606 GN=SH3BP1 PE=1 SV=3" "0.000" "False" "17.734" "8" "5" "6" "5" "701" "75.7" "6.77" "14.98" "5" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00620, Pf03114" "23616" "ENSG00000100092" "SH3BP1" "hsa:23616; Q5R3N0; Q6IBZ2; Q6ZVL9; Q96HQ5; Q9NSQ9; Q9Y3L3" "" "RAC1 GTPase cycle" "1" "0" "1.162" "1.067" "1.095" "1.212" "1.089" "1.051" "1.044" "1.002" "1.786" "327.4" "380.4" "349.3" "358.6" "396.9" "356.6" "344.0" "341.7" "328.2" "584.6" "" "" "" "" "" "" "" "" "" "" "195.9" "197.7" "193.4" "168.4" "184.0" "182.6" "159.9" "153.4" "178.0" "584.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6667619497174905717" "False" "High" "IsMasterProtein" "Q96MW1" "Coiled-coil domain-containing protein 43 OS=Homo sapiens OX=9606 GN=CCDC43 PE=1 SV=2" "0.000" "False" "17.669" "19" "4" "5" "4" "224" "25.2" "4.92" "16.20" "4" "" "cytosol" "" "" "124808" "ENSG00000180329" "CCDC43" "C9JVK9; hsa:124808; Q96MW1" "" "" "0" "0" "0.962" "0.942" "0.952" "1.176" "1.081" "1.206" "1.160" "1.064" "0.602" "298.9" "287.7" "281.5" "284.5" "351.6" "323.1" "360.6" "346.8" "318.0" "180.0" "" "" "" "" "" "" "" "" "" "" "178.9" "149.5" "155.9" "133.6" "163.0" "165.4" "167.7" "155.7" "172.5" "180.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8252267867784187079" "False" "High" "IsMasterProtein" "Q86YP4" "Transcriptional repressor p66-alpha OS=Homo sapiens OX=9606 GN=GATAD2A PE=1 SV=1" "0.000" "False" "17.665" "7" "4" "5" "3" "633" "68.0" "9.94" "14.29" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00320, Pf16563" "54815" "ENSG00000167491" "GATAD2A" "B5MC40; hsa:54815; Q7L3J2; Q86YP4; Q96F28; Q9NPU2; Q9NXS1" "" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "6" "1" "1.071" "1.053" "1.279" "1.500" "0.995" "1.086" "1.086" "1.037" "3.419" "121.5" "130.1" "127.9" "155.5" "182.2" "120.9" "131.9" "131.9" "126.0" "415.5" "" "" "" "" "" "" "" "" "" "" "72.7" "67.6" "70.8" "73.0" "84.5" "61.9" "61.3" "59.2" "68.4" "415.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3391234540397172253" "False" "High" "IsMasterProtein" "Q9H2U1" "ATP-dependent DNA/RNA helicase DHX36 OS=Homo sapiens OX=9606 GN=DHX36 PE=1 SV=2" "0.000" "False" "17.617" "7" "6" "9" "6" "1008" "114.7" "7.68" "14.93" "6" "cell organization and biogenesis;RNA metabolism OR transcription;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "170506" "ENSG00000174953" "DHX36" "B2RB00; hsa:170506; Q70JU3; Q8IYE5; Q9H2U1; Q9P240" "VEGFA-VEGFR2 signaling" "DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "2" "0" "1.219" "1.037" "0.833" "1.837" "1.312" "0.831" "1.195" "1.263" "3.393" "20.1" "24.5" "20.9" "16.8" "37.0" "26.4" "16.7" "24.1" "25.4" "68.3" "" "" "" "" "" "" "" "" "" "" "12.0" "12.8" "11.6" "7.9" "17.1" "13.5" "7.8" "10.8" "13.8" "68.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2594801350968766228" "False" "High" "IsMasterProtein" "Q99986" "Serine/threonine-protein kinase VRK1 OS=Homo sapiens OX=9606 GN=VRK1 PE=1 SV=1" "0.000" "False" "17.573" "14" "5" "6" "5" "396" "45.4" "8.91" "18.88" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus" "kinase activity;other molecular function" "Pf00069" "7443" "ENSG00000100749" "VRK1" "hsa:7443; Q3SYL2; Q99986" "" "Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation" "2" "0" "1.160" "1.019" "1.095" "1.346" "1.286" "1.096" "0.185" "1.230" "11.270" "88.1" "102.3" "89.8" "96.5" "118.6" "113.4" "96.6" "16.3" "108.4" "993.3" "" "" "" "" "" "" "" "" "" "" "52.7" "53.1" "49.7" "45.3" "55.0" "58.0" "44.9" "7.3" "58.8" "993.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2863197479310684416" "False" "High" "IsMasterProtein" "Q96EK6" "Glucosamine 6-phosphate N-acetyltransferase OS=Homo sapiens OX=9606 GN=GNPNAT1 PE=1 SV=1" "0.000" "False" "17.561" "27" "4" "7" "4" "184" "20.7" "7.99" "20.54" "4" "other metabolic processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00583" "64841" "ENSG00000100522" "GNPNAT1" "hsa:64841; Q96EK6" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "0" "0.977" "0.967" "1.008" "0.961" "1.058" "0.866" "1.033" "1.022" "0.770" "506.8" "495.4" "490.2" "510.9" "487.2" "536.4" "438.8" "523.4" "517.9" "390.0" "" "" "" "" "" "" "" "" "" "" "303.3" "257.4" "271.5" "239.8" "225.8" "274.6" "204.0" "235.0" "281.0" "390.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7099090004337322375" "False" "High" "IsMasterProtein" "P63167" "Dynein light chain 1, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL1 PE=1 SV=1" "0.000" "False" "17.550" "45" "3" "7" "2" "89" "10.4" "7.40" "20.07" "3" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01221" "8655" "ENSG00000088986" "DYNLL1" "hsa:8655; P63167; Q15701" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome; Vasopressin-regulated water reabsorption" "MHC class II antigen presentation; Neutrophil degranulation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Intraflagellar transport; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Macroautophagy; Activation of BIM and translocation to mitochondria" "28" "1" "0.935" "0.994" "0.941" "1.169" "1.074" "1.122" "1.121" "1.056" "1.466" "264.9" "247.8" "263.2" "249.2" "309.6" "284.6" "297.1" "297.0" "279.7" "388.4" "" "" "" "" "" "" "" "" "" "" "158.5" "128.8" "145.8" "117.0" "143.5" "145.7" "138.2" "133.4" "151.8" "388.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1108045160068185156" "False" "High" "IsMasterProtein" "P20073" "Annexin A7 OS=Homo sapiens OX=9606 GN=ANXA7 PE=1 SV=3" "0.000" "False" "17.533" "13" "5" "8" "5" "488" "52.7" "5.68" "11.91" "5" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00191" "310" "ENSG00000138279" "ANXA7" "hsa:310; P20073; Q5F2H3; Q5T0M6; Q5T0M7" "" "" "0" "0" "1.069" "1.363" "1.338" "1.154" "1.398" "1.157" "0.593" "1.047" "7.346" "90.6" "96.8" "123.4" "121.1" "104.5" "126.6" "104.7" "53.7" "94.8" "665.2" "" "" "" "" "" "" "" "" "" "" "54.2" "50.3" "68.3" "56.9" "48.4" "64.8" "48.7" "24.1" "51.4" "665.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6370225409205057848" "False" "High" "IsMasterProtein" "Q9UHX1" "Poly(U)-binding-splicing factor PUF60 OS=Homo sapiens OX=9606 GN=PUF60 PE=1 SV=1" "0.000" "False" "17.513" "12" "5" "6" "5" "559" "59.8" "5.29" "16.03" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "22827" "ENSG00000179950" "PUF60" "A8K8K8; hsa:22827; Q969E7; Q96D94; Q96H63; Q99628; Q9NZA0; Q9UHX1; Q9UJY7" "" "mRNA Splicing - Major Pathway" "1" "0" "1.163" "1.678" "1.050" "1.852" "1.741" "1.375" "0.923" "1.372" "4.086" "30.9" "35.9" "51.8" "32.4" "57.2" "53.8" "42.5" "28.5" "42.4" "126.2" "" "" "" "" "" "" "" "" "" "" "18.5" "18.7" "28.7" "15.2" "26.5" "27.5" "19.8" "12.8" "23.0" "126.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8291794919948140528" "False" "High" "IsMasterProtein" "Q14203" "Dynactin subunit 1 OS=Homo sapiens OX=9606 GN=DCTN1 PE=1 SV=3" "0.000" "False" "17.492" "4" "5" "6" "5" "1278" "141.6" "5.81" "16.08" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf12455" "1639" "ENSG00000204843" "DCTN1" "A8MY36; B4DM45; E9PFS5; E9PGE1; G5E9H4; hsa:1639; O95296; Q14203; Q6IQ37; Q9BRM9; Q9UIU1; Q9UIU2" "Vasopressin-regulated water reabsorption; HDAC6 interactions in the central nervous system" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Signaling by ALK fusions and activated point mutants; XBP1(S) activates chaperone genes" "8" "0" "1.473" "1.379" "1.331" "1.336" "1.608" "1.455" "0.285" "1.187" "14.042" "50.9" "75.1" "70.3" "67.8" "68.1" "81.9" "74.1" "14.5" "60.5" "715.3" "" "" "" "" "" "" "" "" "" "" "30.5" "39.0" "38.9" "31.8" "31.5" "41.9" "34.5" "6.5" "32.8" "715.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7031077161766424227" "False" "High" "IsMasterProtein" "Q4V328" "GRIP1-associated protein 1 OS=Homo sapiens OX=9606 GN=GRIPAP1 PE=1 SV=2" "0.000" "False" "17.474" "8" "7" "7" "7" "841" "95.9" "5.11" "16.46" "7" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "" "56850" "ENSG00000068400; ENSG00000292219" "GRIPAP1" "A6NL78; hsa:56850; Q3MJ75; Q4V327; Q4V328; Q4V330; Q5HYG1; Q6N046; Q96DH8; Q9NQ43; Q9ULQ3" "" "" "0" "0" "0.989" "0.962" "1.086" "1.250" "0.967" "1.040" "1.032" "0.969" "1.633" "194.3" "192.3" "186.9" "211.1" "242.9" "187.8" "202.1" "200.5" "188.3" "317.3" "" "" "" "" "" "" "" "" "" "" "116.3" "99.9" "103.5" "99.1" "112.6" "96.2" "94.0" "90.0" "102.2" "317.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6980726595472841033" "False" "High" "IsMasterProtein" "P24941" "Cyclin-dependent kinase 2 OS=Homo sapiens OX=9606 GN=CDK2 PE=1 SV=2" "0.000" "False" "17.461" "17" "5" "10" "4" "298" "33.9" "8.68" "27.06" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069" "1017" "ENSG00000123374" "CDK2" "A8K7C6; hsa:1017; O75100; P24941" "miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; DNA replication; p53 transcriptional gene network; Pleural mesothelioma; Sphingolipid metabolism in senescence; Urotensin-II-mediated signaling pathway; ID signaling pathway; TROP2 regulatory signaling; DNA damage response" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; Regulation of TP53 Degradation; SCF(Skp2)-mediated degradation of p27/p21; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; G2 Phase; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Telomere Extension By Telomerase; Regulation of APC/C activators between G1/S and early anaphase; Senescence-Associated Secretory Phenotype (SASP); Factors involved in megakaryocyte development and platelet production; Processing of DNA double-strand break ends; Cyclin A/B1/B2 associated events during G2/M transition; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Transcriptional regulation of granulopoiesis; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response; PTK6 Regulates Cell Cycle" "47" "0" "0.988" "0.994" "1.017" "1.103" "1.067" "1.175" "1.303" "1.279" "0.898" "339.1" "334.9" "337.2" "345.0" "374.1" "361.7" "398.5" "441.9" "433.8" "304.4" "" "" "" "" "" "" "" "" "" "" "202.9" "174.0" "186.7" "161.9" "173.4" "185.2" "185.3" "198.4" "235.3" "304.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1040458896990308382" "False" "High" "IsMasterProtein" "Q9Y5J7" "Mitochondrial import inner membrane translocase subunit Tim9 OS=Homo sapiens OX=9606 GN=TIMM9 PE=1 SV=1" "0.000" "False" "17.455" "47" "4" "8" "4" "89" "10.4" "7.21" "20.99" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "26520" "ENSG00000100575" "TIMM9" "B2R584; hsa:26520; Q9Y5J7" "" "Mitochondrial protein degradation; Mitochondrial protein import" "2" "0" "1.039" "1.122" "0.913" "1.010" "1.162" "0.917" "1.101" "1.069" "0.324" "521.3" "541.5" "585.2" "475.8" "526.7" "606.0" "478.1" "574.1" "557.3" "168.8" "" "" "" "" "" "" "" "" "" "" "312.0" "281.4" "324.1" "223.4" "244.1" "310.2" "222.3" "257.7" "302.3" "168.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6636555355274069790" "False" "High" "IsMasterProtein" "Q9Y5J9" "Mitochondrial import inner membrane translocase subunit Tim8 B OS=Homo sapiens OX=9606 GN=TIMM8B PE=1 SV=1" "0.000" "False" "17.438" "45" "4" "14" "4" "83" "9.3" "5.12" "38.33" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02953" "26521" "ENSG00000150779" "TIMM8B" "B0YJA5; hsa:26521; Q3KQS9; Q9UN04; Q9Y5J9" "" "Mitochondrial protein import" "1" "0" "0.910" "0.940" "0.903" "1.006" "0.970" "1.067" "0.949" "0.977" "0.743" "658.4" "599.3" "618.6" "594.5" "662.4" "638.7" "702.3" "625.0" "643.4" "489.1" "" "" "" "" "" "" "" "" "" "" "394.0" "311.4" "342.6" "279.1" "307.0" "327.0" "326.6" "280.6" "349.1" "489.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5753903603639706733" "False" "High" "IsMasterProtein" "Q15021" "Condensin complex subunit 1 OS=Homo sapiens OX=9606 GN=NCAPD2 PE=1 SV=3" "0.000" "False" "17.369" "4" "5" "6" "5" "1401" "157.1" "6.61" "14.87" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12717, Pf12922" "9918" "ENSG00000010292" "NCAPD2" "D3DUR4; hsa:9918; Q15021; Q8N6U3" "" "Condensation of Prometaphase Chromosomes" "1" "0" "0.910" "0.901" "0.902" "1.015" "1.070" "1.055" "0.462" "1.030" "4.782" "129.3" "117.7" "116.6" "116.6" "131.2" "138.4" "136.4" "59.7" "133.2" "618.3" "" "" "" "" "" "" "" "" "" "" "77.4" "61.2" "64.5" "54.8" "60.8" "70.8" "63.4" "26.8" "72.3" "618.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4835883825689200365" "False" "High" "IsMasterProtein" "Q92979" "Ribosomal RNA small subunit methyltransferase NEP1 OS=Homo sapiens OX=9606 GN=EMG1 PE=1 SV=4" "0.000" "False" "17.314" "14" "3" "9" "3" "244" "26.7" "9.17" "23.18" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03587" "10436" "ENSG00000126749" "EMG1" "hsa:10436; O00675; O00726; Q92979" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.058" "1.004" "0.957" "0.948" "0.976" "1.169" "0.969" "1.127" "0.583" "529.4" "559.9" "531.7" "506.5" "501.6" "516.7" "619.1" "513.1" "596.8" "308.6" "" "" "" "" "" "" "" "" "" "" "316.8" "291.0" "294.4" "237.8" "232.5" "264.5" "287.9" "230.4" "323.8" "308.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3405025144750981774" "False" "High" "IsMasterProtein" "P52732" "Kinesin-like protein KIF11 OS=Homo sapiens OX=9606 GN=KIF11 PE=1 SV=2" "0.000" "False" "17.265" "5" "5" "5" "5" "1056" "119.1" "5.64" "13.95" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf13931" "3832" "ENSG00000138160" "KIF11" "A0AV49; B2RMV3; hsa:3832; P52732; Q15716; Q5VWX0" "" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins" "3" "0" "1.087" "1.236" "1.177" "1.087" "1.212" "1.261" "0.532" "1.255" "6.045" "177.2" "192.6" "219.0" "208.6" "192.6" "214.7" "223.5" "94.2" "222.4" "1071.1" "" "" "" "" "" "" "" "" "" "" "106.0" "100.1" "121.3" "97.9" "89.3" "109.9" "103.9" "42.3" "120.6" "1071.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8650097818779685703" "False" "High" "IsMasterProtein" "P62857" "Small ribosomal subunit protein eS28 OS=Homo sapiens OX=9606 GN=RPS28 PE=1 SV=1" "0.000" "False" "17.264" "46" "3" "16" "3" "69" "7.8" "10.70" "20.68" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01200" "6234" "ENSG00000233927" "RPS28" "hsa:6234; P25112; P62857" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "0.858" "0.841" "0.950" "0.987" "0.810" "0.952" "0.867" "0.825" "0.389" "708.0" "607.5" "595.2" "672.4" "699.1" "573.6" "673.7" "613.9" "584.0" "275.4" "" "" "" "" "" "" "" "" "" "" "423.7" "315.7" "329.6" "315.7" "324.0" "293.7" "313.3" "275.6" "316.8" "275.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3934264021141742446" "False" "High" "IsMasterProtein" "Q9UI12" "V-type proton ATPase subunit H OS=Homo sapiens OX=9606 GN=ATP6V1H PE=1 SV=1" "0.000" "False" "17.247" "10" "4" "5" "4" "483" "55.8" "6.48" "13.57" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "transporter activity;enzyme regulator activity" "Pf03224, Pf11698" "51606" "ENSG00000047249" "ATP6V1H" "B3KMR0; hsa:51606; Q6PK44; Q9H3E3; Q9UI12; Q9Y300" "Proximal tubule transport" "Nef Mediated CD4 Down-regulation; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport; Nef Mediated CD8 Down-regulation; Blockage of phagosome acidification" "9" "0" "1.189" "1.057" "1.097" "0.984" "1.332" "1.121" "1.074" "1.085" "1.537" "239.3" "284.7" "253.0" "262.6" "235.6" "318.8" "268.4" "256.9" "259.6" "367.8" "" "" "" "" "" "" "" "" "" "" "143.2" "147.9" "140.1" "123.3" "109.2" "163.2" "124.8" "115.4" "140.8" "367.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7697340015663074004" "False" "High" "IsMasterProtein" "P56211" "cAMP-regulated phosphoprotein 19 OS=Homo sapiens OX=9606 GN=ARPP19 PE=1 SV=2" "0.000" "False" "17.190" "33" "3" "7" "2" "112" "12.3" "9.09" "23.00" "3" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf04667" "10776" "ENSG00000128989" "ARPP19" "B2R497; hsa:10776; P56211; Q6IAM2; Q86TA6; Q9UD70" "" "MASTL Facilitates Mitotic Progression" "1" "0" "0.913" "0.905" "0.925" "0.963" "0.919" "1.043" "1.136" "0.962" "0.424" "298.4" "272.5" "270.2" "275.9" "287.4" "274.2" "311.3" "338.9" "287.2" "126.6" "" "" "" "" "" "" "" "" "" "" "178.6" "141.6" "149.6" "129.5" "133.2" "140.4" "144.7" "152.2" "155.8" "126.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4830311805247258078" "False" "High" "IsMasterProtein" "Q9NPD3" "Exosome complex component RRP41 OS=Homo sapiens OX=9606 GN=EXOSC4 PE=1 SV=3" "0.000" "False" "17.173" "18" "4" "7" "4" "245" "26.4" "6.52" "22.09" "4" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "54512" "ENSG00000178896" "EXOSC4" "hsa:54512; Q9NPD3" "Ciliary landscape" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "7" "0" "0.914" "0.883" "0.905" "0.992" "0.965" "0.945" "1.036" "0.898" "0.863" "665.4" "608.2" "587.9" "602.0" "659.8" "642.3" "628.6" "689.1" "597.7" "574.3" "" "" "" "" "" "" "" "" "" "" "398.2" "316.1" "325.6" "282.6" "305.8" "328.8" "292.3" "309.4" "324.3" "574.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-398928808883879512" "False" "High" "IsMasterProtein" "P07311" "Acylphosphatase-1 OS=Homo sapiens OX=9606 GN=ACYP1 PE=1 SV=2" "0.000" "False" "17.171" "45" "5" "8" "5" "99" "11.3" "9.31" "21.73" "5" "other metabolic processes" "" "other molecular function" "Pf00708" "97" "ENSG00000119640" "ACYP1" "A6NDV8; B2R590; hsa:97; P07311" "" "" "0" "0" "0.987" "0.957" "0.919" "0.999" "0.908" "1.013" "0.979" "0.963" "0.718" "425.5" "419.8" "407.3" "391.0" "425.2" "386.4" "431.2" "416.7" "410.0" "305.4" "" "" "" "" "" "" "" "" "" "" "254.7" "218.2" "225.5" "183.5" "197.1" "197.8" "200.5" "187.1" "222.4" "305.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5817906340983341960" "False" "High" "IsMasterProtein" "P61956" "Small ubiquitin-related modifier 2 OS=Homo sapiens OX=9606 GN=SUMO2 PE=1 SV=3" "0.000" "False" "17.157" "23" "2" "13" "1" "95" "10.9" "5.50" "47.93" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11976" "6613" "ENSG00000188612" "SUMO2" "B2R4I2; hsa:6613; P55855; P61956; Q32Q42; Q6IPZ6; Q96HK1" "TAR syndrome" "SUMOylation of DNA damage response and repair proteins; Processing of DNA double-strand break ends; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "15" "0" "0.980" "1.092" "0.901" "0.956" "1.006" "0.999" "1.036" "0.970" "0.807" "153.0" "149.9" "167.1" "137.8" "146.2" "153.9" "152.8" "158.4" "148.4" "123.4" "" "" "" "" "" "" "" "" "" "" "91.5" "77.9" "92.5" "64.7" "67.8" "78.8" "71.0" "71.1" "80.5" "123.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7918100123629271451" "False" "High" "IsMasterProtein" "Q9NWV4" "CXXC motif containing zinc binding protein OS=Homo sapiens OX=9606 GN=CZIB PE=1 SV=1" "0.000" "False" "17.132" "31" "4" "4" "4" "160" "18.0" "5.01" "14.82" "4" "" "" "other molecular function" "Pf05907" "54987" "ENSG00000162384" "CZIB" "hsa:54987; Q9NWV4" "" "" "0" "0" "1.155" "1.163" "1.025" "1.109" "1.075" "1.005" "1.147" "1.041" "0.906" "467.4" "539.8" "543.6" "478.9" "518.6" "502.6" "469.5" "536.0" "486.5" "423.7" "" "" "" "" "" "" "" "" "" "" "279.7" "280.5" "301.1" "224.8" "240.4" "257.3" "218.3" "240.6" "263.9" "423.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "439747598683617185" "False" "High" "IsMasterProtein" "Q9UI10" "Translation initiation factor eIF2B subunit delta OS=Homo sapiens OX=9606 GN=EIF2B4 PE=1 SV=2" "0.000" "False" "17.096" "11" "4" "7" "4" "523" "57.5" "9.38" "21.19" "4" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "8890" "ENSG00000115211" "EIF2B4" "hsa:8890; Q53RY7; Q5BJF4; Q9BUV9; Q9UBG4; Q9UI10; Q9UIQ9; Q9UJ95" "Translation factors; Primary ovarian insufficiency" "Recycling of eIF2:GDP" "3" "0" "1.272" "1.311" "1.436" "1.276" "1.280" "1.185" "1.605" "1.277" "1.863" "80.8" "102.7" "105.9" "116.0" "103.1" "103.5" "95.8" "129.7" "103.2" "150.5" "" "" "" "" "" "" "" "" "" "" "48.3" "53.4" "58.7" "54.5" "47.8" "53.0" "44.5" "58.2" "56.0" "150.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2179215368678635356" "False" "High" "IsMasterProtein" "Q8IYB8" "ATP-dependent RNA helicase SUPV3L1, mitochondrial OS=Homo sapiens OX=9606 GN=SUPV3L1 PE=1 SV=1" "0.000" "False" "17.084" "6" "4" "7" "4" "786" "87.9" "7.99" "10.04" "4" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00271, Pf12513, Pf18114, Pf18147" "6832" "ENSG00000156502" "SUPV3L1" "A8K301; hsa:6832; O43630; Q8IYB8" "" "Mitochondrial RNA degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3279905099390366435" "False" "High" "IsMasterProtein" "Q6FIF0" "AN1-type zinc finger protein 6 OS=Homo sapiens OX=9606 GN=ZFAND6 PE=1 SV=2" "0.000" "False" "17.044" "21" "3" "6" "3" "208" "22.5" "7.20" "13.50" "3" "cell organization and biogenesis;other biological processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf01428, Pf01754" "54469" "ENSG00000086666" "ZFAND6" "D3DW92; D3DW94; hsa:54469; O95792; Q6FIF0; Q9BQF7; Q9GZY3" "" "Peroxisomal protein import" "1" "0" "0.993" "0.947" "0.992" "1.032" "0.857" "1.066" "0.905" "0.810" "0.509" "297.9" "295.9" "282.2" "295.6" "307.5" "255.3" "317.6" "269.5" "241.2" "151.7" "" "" "" "" "" "" "" "" "" "" "178.3" "153.8" "156.3" "138.8" "142.5" "130.7" "147.7" "121.0" "130.9" "151.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3263618484320997085" "False" "High" "IsMasterProtein" "Q9H098" "Protein FAM107B OS=Homo sapiens OX=9606 GN=FAM107B PE=1 SV=1" "0.000" "False" "17.042" "24" "3" "10" "3" "131" "15.5" "8.29" "27.17" "3" "" "" "" "Pf06625" "83641" "ENSG00000065809" "FAM107B" "A8K1P4; D3DRT2; hsa:83641; Q5T9K7; Q5T9K8; Q6ZSI4; Q9H098" "" "" "0" "0" "0.939" "0.953" "0.888" "1.057" "0.976" "1.055" "1.046" "0.888" "0.330" "747.1" "701.9" "712.0" "663.7" "789.9" "728.9" "788.5" "781.4" "663.3" "246.8" "" "" "" "" "" "" "" "" "" "" "447.1" "364.7" "394.3" "311.6" "366.1" "373.1" "366.6" "350.8" "359.9" "246.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6717857941727919032" "False" "High" "IsMasterProtein" "Q8WZA9" "Immunity-related GTPase family Q protein OS=Homo sapiens OX=9606 GN=IRGQ PE=1 SV=1" "0.000" "False" "17.011" "11" "5" "5" "5" "623" "62.7" "4.88" "14.60" "5" "" "" "other molecular function" "" "126298" "ENSG00000167378" "IRGQ" "B2RNP3; hsa:126298; Q8WZA9" "" "" "0" "0" "1.407" "1.210" "1.374" "1.444" "1.212" "0.893" "1.257" "1.693" "6.252" "28.7" "40.4" "34.8" "39.5" "41.5" "34.8" "25.7" "36.1" "48.7" "179.7" "" "" "" "" "" "" "" "" "" "" "17.2" "21.0" "19.3" "18.5" "19.2" "17.8" "11.9" "16.2" "26.4" "179.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8303204193391828869" "False" "High" "IsMasterProtein" "Q8WUI4" "Histone deacetylase 7 OS=Homo sapiens OX=9606 GN=HDAC7 PE=1 SV=2" "0.000" "False" "17.002" "7" "6" "6" "6" "952" "102.9" "7.58" "12.02" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00850" "51564" "ENSG00000061273" "HDAC7" "B3KY08; B4DWI0; B4E0Q5; hsa:51564; Q6P1W9; Q6W9G7; Q7Z4K2; Q7Z5I1; Q8WUI4; Q96K01; Q9BR73; Q9H7L0; Q9NW41; Q9NWA9; Q9NYK9; Q9UFU7" "MicroRNAs in cardiomyocyte hypertrophy; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Gastrin signaling pathway" "SUMOylation of DNA damage response and repair proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Regulation of PTEN gene transcription; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway" "13" "0" "1.025" "1.189" "1.239" "0.921" "1.188" "1.354" "1.152" "0.985" "1.075" "62.7" "64.3" "74.5" "77.7" "57.8" "74.5" "84.9" "72.2" "61.8" "67.4" "" "" "" "" "" "" "" "" "" "" "37.5" "33.4" "41.3" "36.5" "26.8" "38.1" "39.5" "32.4" "33.5" "67.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-700006474042265009" "False" "High" "IsMasterProtein" "Q7Z739" "YTH domain-containing family protein 3 OS=Homo sapiens OX=9606 GN=YTHDF3 PE=1 SV=1" "0.000" "False" "16.961" "8" "5" "5" "3" "585" "63.8" "9.04" "14.91" "5" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04146" "253943" "ENSG00000185728" "YTHDF3" "B3KXL4; hsa:253943; Q63Z37; Q659A3; Q7Z739" "" "" "0" "0" "0.912" "0.986" "0.841" "1.003" "0.982" "0.990" "0.907" "1.068" "0.923" "137.3" "125.2" "135.4" "115.4" "137.7" "134.8" "135.9" "124.6" "146.6" "126.8" "" "" "" "" "" "" "" "" "" "" "82.2" "65.1" "75.0" "54.2" "63.8" "69.0" "63.2" "55.9" "79.5" "126.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-115181160460478952" "False" "High" "IsMasterProtein" "P35754" "Glutaredoxin-1 OS=Homo sapiens OX=9606 GN=GLRX PE=1 SV=2" "0.000" "False" "16.932" "30" "2" "10" "2" "106" "11.8" "8.09" "30.63" "2" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00462" "2745" "ENSG00000173221" "GLRX" "B2R4L2; hsa:2745; P35754; Q3KQS1; Q6ICT1" "One-carbon metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "0.961" "0.848" "0.941" "1.074" "1.037" "1.148" "1.128" "0.982" "0.483" "361.4" "347.2" "306.4" "340.1" "388.1" "374.6" "414.9" "407.8" "355.0" "174.7" "" "" "" "" "" "" "" "" "" "" "216.3" "180.4" "169.7" "159.7" "179.9" "191.8" "192.9" "183.1" "192.6" "174.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8670958433918101160" "False" "High" "IsMasterProtein" "P26373" "Large ribosomal subunit protein eL13 OS=Homo sapiens OX=9606 GN=RPL13 PE=1 SV=4" "0.000" "False" "16.931" "17" "4" "6" "4" "211" "24.2" "11.65" "16.23" "4" "protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01294" "6137" "ENSG00000167526" "RPL13" "B4DLX3; F5H1S2; hsa:6137; P26373; Q3KQT8; Q567Q8; Q9BPX0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.946" "1.018" "1.057" "1.015" "1.054" "1.015" "1.085" "1.127" "0.582" "316.5" "299.3" "322.1" "334.6" "321.4" "333.7" "321.3" "343.5" "356.7" "184.2" "" "" "" "" "" "" "" "" "" "" "189.4" "155.5" "178.3" "157.1" "149.0" "170.8" "149.4" "154.2" "193.5" "184.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1347928425928225454" "False" "High" "IsMasterProtein" "O60925" "Prefoldin subunit 1 OS=Homo sapiens OX=9606 GN=PFDN1 PE=1 SV=2" "0.000" "False" "16.911" "30" "4" "10" "4" "122" "14.2" "6.81" "30.79" "4" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "5201" "ENSG00000113068" "PFDN1" "B2RD02; hsa:5201; O60925; Q53F95; Q96EX6" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "0.981" "1.028" "1.029" "1.053" "1.029" "1.083" "1.126" "0.979" "0.645" "955.3" "937.5" "981.9" "983.0" "1005.9" "982.7" "1034.2" "1076.1" "935.0" "615.8" "" "" "" "" "" "" "" "" "" "" "571.7" "487.2" "543.8" "461.5" "466.3" "503.1" "480.9" "483.1" "507.3" "615.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8735053905858643513" "False" "High" "IsMasterProtein" "Q16401" "26S proteasome non-ATPase regulatory subunit 5 OS=Homo sapiens OX=9606 GN=PSMD5 PE=1 SV=3" "0.000" "False" "16.904" "12" "6" "13" "6" "504" "56.2" "5.48" "28.55" "6" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf10508" "5711" "ENSG00000095261" "PSMD5" "B4DZM8; hsa:5711; Q15045; Q16401; Q4VXG8" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "61" "0" "0.944" "1.045" "0.971" "1.179" "1.143" "1.163" "1.097" "1.157" "1.446" "216.8" "204.7" "226.6" "210.6" "255.8" "247.8" "252.2" "237.9" "250.9" "313.5" "" "" "" "" "" "" "" "" "" "" "129.8" "106.4" "125.5" "98.9" "118.5" "126.9" "117.3" "106.8" "136.1" "313.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518477556068487686" "False" "High" "IsMasterProtein" "P30046" "D-dopachrome decarboxylase OS=Homo sapiens OX=9606 GN=DDT PE=1 SV=3" "0.000" "False" "16.895" "42" "5" "26" "5" "118" "12.7" "7.30" "51.58" "5" "other metabolic processes;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01187" "1652" "ENSG00000099977; ENSG00000275003" "DDT" "B7Z522; hsa:1652; O00774; O60787; P30046; Q13534" "" "" "0" "0" "0.960" "0.964" "0.978" "1.001" "0.989" "1.069" "1.123" "1.040" "0.517" "979.5" "940.6" "943.7" "957.7" "980.2" "968.8" "1047.4" "1100.2" "1018.9" "506.6" "" "" "" "" "" "" "" "" "" "" "586.2" "488.8" "522.6" "449.6" "454.3" "495.9" "487.0" "493.9" "552.8" "506.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3851715051474233643" "False" "High" "IsMasterProtein" "Q9P2A4" "ABI gene family member 3 OS=Homo sapiens OX=9606 GN=ABI3 PE=1 SV=2" "0.000" "False" "16.893" "15" "5" "8" "5" "366" "39.0" "5.08" "16.04" "5" "cell organization and biogenesis;stress response;other biological processes" "other cell component" "cytoskeletal activity;other molecular function" "Pf07815, Pf14604" "51225" "ENSG00000108798" "ABI3" "C9IZN8; hsa:51225; Q9H0P6; Q9P2A4" "" "" "0" "0" "1.114" "1.091" "1.102" "1.265" "1.274" "1.220" "0.980" "1.061" "1.376" "143.3" "159.6" "156.4" "157.9" "181.3" "182.7" "174.9" "140.5" "152.0" "197.2" "" "" "" "" "" "" "" "" "" "" "85.8" "82.9" "86.6" "74.1" "84.1" "93.5" "81.3" "63.1" "82.5" "197.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2739049111137792080" "False" "High" "IsMasterProtein" "P13861" "cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR2A PE=1 SV=2" "0.000" "False" "16.841" "14" "5" "6" "5" "404" "45.5" "5.07" "16.46" "5" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5576" "ENSG00000114302" "PRKAR2A" "hsa:5576; P13861; Q16823; Q9BUB1" "Myometrial relaxation and contraction pathways; G protein signaling pathways; TGF-beta signaling pathway; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; GDNF signaling; Calcium regulation in cardiac cells; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "GPER1 signaling; FCGR3A-mediated IL10 synthesis; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; ROBO receptors bind AKAP5" "22" "0" "0.991" "1.052" "0.967" "1.063" "1.069" "1.022" "1.043" "1.062" "1.932" "193.7" "192.0" "203.8" "187.3" "205.9" "207.0" "197.9" "202.1" "205.6" "374.2" "" "" "" "" "" "" "" "" "" "" "115.9" "99.8" "112.9" "87.9" "95.5" "106.0" "92.0" "90.7" "111.6" "374.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4076214252454433299" "False" "High" "IsMasterProtein" "Q969G3" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 OS=Homo sapiens OX=9606 GN=SMARCE1 PE=1 SV=2" "0.000" "False" "16.838" "11" "4" "7" "4" "411" "46.6" "4.88" "18.38" "4" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505" "6605" "ENSG00000073584" "SMARCE1" "B3KMC1; B4DFR4; C0IMW4; C0IMW5; C0IMW7; H7C3F6; hsa:6605; O43539; Q969G3" "Androgen receptor signaling pathway; Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "6" "0" "0.731" "0.973" "0.898" "0.993" "0.985" "1.000" "0.726" "0.968" "3.797" "154.6" "113.0" "150.5" "138.8" "153.5" "152.2" "154.6" "112.3" "149.6" "586.9" "" "" "" "" "" "" "" "" "" "" "92.5" "58.7" "83.3" "65.2" "71.2" "77.9" "71.9" "50.4" "81.2" "586.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3689472973843486022" "False" "High" "IsMasterProtein" "O00505" "Importin subunit alpha-4 OS=Homo sapiens OX=9606 GN=KPNA3 PE=1 SV=2" "0.000" "False" "16.837" "11" "5" "11" "4" "521" "57.8" "4.94" "23.23" "5" "cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3839" "ENSG00000102753" "KPNA3" "hsa:3839; O00191; O00505; O43195; Q5JVM9; Q8IYQ9; Q96AA7" "" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways" "2" "0" "1.009" "0.969" "1.052" "0.982" "1.024" "1.060" "0.664" "1.067" "3.597" "141.5" "142.7" "137.1" "148.9" "139.0" "144.9" "149.9" "93.9" "151.0" "508.8" "" "" "" "" "" "" "" "" "" "" "84.7" "74.2" "76.0" "69.9" "64.4" "74.2" "69.7" "42.2" "81.9" "508.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8162183631045646946" "False" "High" "IsMasterProtein" "Q01085" "Nucleolysin TIAR OS=Homo sapiens OX=9606 GN=TIAL1 PE=1 SV=1" "0.000" "False" "16.810" "16" "5" "11" "2" "375" "41.6" "7.74" "17.15" "5" "cell cycle OR cell proliferation;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "7073" "ENSG00000151923" "TIAL1" "A8K3T0; A8K4L9; hsa:7073; Q01085" "" "FGFR2 alternative splicing" "1" "0" "1.560" "1.918" "2.148" "1.141" "1.563" "1.522" "1.795" "2.231" "2.056" "30.4" "47.3" "58.2" "65.2" "34.6" "47.4" "46.2" "54.5" "67.7" "62.4" "" "" "" "" "" "" "" "" "" "" "18.2" "24.6" "32.2" "30.6" "16.1" "24.3" "21.5" "24.5" "36.7" "62.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9221367924290970171" "False" "High" "IsMasterProtein" "Q07812" "Apoptosis regulator BAX OS=Homo sapiens OX=9606 GN=BAX PE=1 SV=1" "0.000" "False" "16.789" "19" "3" "11" "3" "192" "21.2" "5.22" "19.65" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00452" "581" "ENSG00000087088" "BAX" "A8K4W1; hsa:581; P55269; Q07812; Q07814; Q07815; Q8WZ49; Q9NR76; Q9NYG7; Q9UCZ6; Q9UCZ7; Q9UQD6" "miRNA regulation of DNA damage response; TP53 network; Leptin signaling pathway; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Mammary gland development pathway - Involution (Stage 4 of 4); Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Overview of nanoparticle effects; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Regulation of apoptosis by parathyroid hormone-related protein; miRNA regulation of p53 pathway in prostate cancer; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Melanoma; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; p53 transcriptional gene network; Pleural mesothelioma; Complement system in neuronal development and plasticity; Urotensin-II-mediated signaling pathway; TROP2 regulatory signaling; IL-26 signaling pathways; HDAC6 interactions in the central nervous system; DNA damage response; DNA damage response (only ATM dependent)" "Release of apoptotic factors from the mitochondria; Pyroptosis; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Transcriptional regulation by RUNX2; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Activation, translocation and oligomerization of BAX; NTRK3 as a dependence receptor" "48" "0" "0.990" "0.886" "1.073" "1.242" "1.071" "1.304" "1.211" "1.021" "0.768" "371.0" "367.4" "328.9" "398.0" "460.7" "397.5" "483.8" "449.3" "378.8" "284.9" "" "" "" "" "" "" "" "" "" "" "222.0" "190.9" "182.1" "186.9" "213.5" "203.5" "225.0" "201.7" "205.5" "284.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "410623999248744867" "False" "High" "IsMasterProtein" "Q6PKG0" "La-related protein 1 OS=Homo sapiens OX=9606 GN=LARP1 PE=1 SV=2" "0.000" "False" "16.788" "7" "7" "8" "7" "1096" "123.4" "8.82" "9.84" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf05383, Pf21071" "23367" "ENSG00000155506" "LARP1" "hsa:23367; O94836; Q6PKG0; Q8N4M2; Q8NB73; Q9UFD7" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "4" "0" "1.100" "1.109" "1.033" "1.021" "1.036" "1.175" "1.203" "0.934" "0.642" "85.8" "94.4" "95.2" "88.7" "87.6" "88.9" "100.8" "103.2" "80.1" "55.1" "" "" "" "" "" "" "" "" "" "" "51.4" "49.0" "52.7" "41.6" "40.6" "45.5" "46.9" "46.3" "43.5" "55.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6928651678899214990" "False" "High" "IsMasterProtein" "Q86VM9" "Zinc finger CCCH domain-containing protein 18 OS=Homo sapiens OX=9606 GN=ZC3H18 PE=1 SV=2" "0.000" "False" "16.774" "7" "4" "7" "4" "953" "106.3" "8.32" "21.65" "4" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf18044" "124245" "ENSG00000158545" "ZC3H18" "hsa:124245; Q86VM9; Q96DG4; Q96MP7" "" "" "0" "0" "0.979" "1.327" "0.875" "1.037" "0.955" "0.916" "0.672" "0.790" "0.795" "23.6" "23.1" "31.3" "20.7" "24.5" "22.5" "21.6" "15.9" "18.7" "18.8" "" "" "" "" "" "" "" "" "" "" "14.1" "12.0" "17.4" "9.7" "11.4" "11.5" "10.1" "7.1" "10.1" "18.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4536078631798452952" "False" "High" "IsMasterProtein" "Q6P582" "Mitotic-spindle organizing protein 2A OS=Homo sapiens OX=9606 GN=MZT2A PE=1 SV=2" "0.000" "False" "16.739" "23" "2" "3" "2" "158" "16.2" "9.64" "11.00" "2" "" "cytosol;cytoskeleton;nucleus" "" "Pf12926" "653784" "ENSG00000173272" "MZT2A" "hsa:653784; Q3SWV8; Q6P582; Q8WVB2" "2q21.1 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "3" "0" "1.046" "0.994" "0.800" "0.909" "0.742" "1.044" "0.982" "0.660" "0.553" "85.0" "88.9" "84.5" "68.0" "77.3" "63.1" "88.7" "83.5" "56.1" "47.0" "" "" "" "" "" "" "" "" "" "" "50.9" "46.2" "46.8" "31.9" "35.8" "32.3" "41.3" "37.5" "30.4" "47.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2588985702309620212" "False" "High" "IsMasterProtein" "O75792" "Ribonuclease H2 subunit A OS=Homo sapiens OX=9606 GN=RNASEH2A PE=1 SV=2" "0.000" "False" "16.732" "17" "5" "5" "5" "299" "33.4" "5.25" "16.68" "5" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01351" "10535" "ENSG00000104889" "RNASEH2A" "B2RCY1; hsa:10535; O75792; Q96F11" "" "" "0" "0" "1.061" "1.031" "1.099" "1.132" "1.100" "1.083" "0.884" "1.058" "2.807" "213.6" "226.7" "220.2" "234.8" "241.7" "234.9" "231.4" "188.9" "225.9" "599.6" "" "" "" "" "" "" "" "" "" "" "127.8" "117.8" "121.9" "110.2" "112.0" "120.3" "107.6" "84.8" "122.6" "599.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5839197527488627088" "False" "High" "IsMasterProtein" "P09110" "3-ketoacyl-CoA thiolase, peroxisomal OS=Homo sapiens OX=9606 GN=ACAA1 PE=1 SV=2" "0.000" "False" "16.728" "16" "3" "4" "3" "424" "44.3" "8.44" "10.60" "3" "other metabolic processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00108, Pf02803" "30" "ENSG00000060971" "ACAA1" "G5E935; hsa:30; P09110; Q96CA6" "PPAR-alpha pathway; Nuclear receptors meta-pathway; Amino acid metabolism; PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX)" "Neutrophil degranulation; TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6575601821171362980" "False" "High" "IsMasterProtein" "P39019" "Small ribosomal subunit protein eS19 OS=Homo sapiens OX=9606 GN=RPS19 PE=1 SV=2" "0.000" "False" "16.713" "34" "5" "11" "5" "145" "16.1" "10.32" "29.55" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01090" "6223" "ENSG00000105372" "RPS19" "hsa:6223; P39019" "Complement system; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "20" "0" "0.939" "1.001" "0.975" "0.949" "0.962" "0.903" "0.897" "0.972" "0.571" "748.2" "702.9" "749.0" "729.3" "709.7" "720.1" "675.7" "670.8" "727.0" "427.5" "" "" "" "" "" "" "" "" "" "" "447.8" "365.3" "414.8" "342.4" "329.0" "368.6" "314.2" "301.2" "394.4" "427.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7667668452715930583" "False" "High" "IsMasterProtein" "O60264" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 OS=Homo sapiens OX=9606 GN=SMARCA5 PE=1 SV=1" "0.000" "False" "16.709" "7" "6" "7" "6" "1052" "121.8" "8.09" "13.14" "6" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf09110, Pf09111" "8467" "ENSG00000153147" "SMARCA5" "hsa:8467; O60264" "10q11.21q11.23 copy number variation syndrome" "Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression" "5" "0" "1.417" "0.960" "0.829" "1.080" "1.145" "0.936" "0.606" "1.015" "6.895" "18.0" "25.6" "17.3" "15.0" "19.5" "20.7" "16.9" "10.9" "18.3" "124.4" "" "" "" "" "" "" "" "" "" "" "10.8" "13.3" "9.6" "7.0" "9.0" "10.6" "7.9" "4.9" "9.9" "124.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1449875230825116072" "False" "High" "IsMasterProtein" "Q03252" "Lamin-B2 OS=Homo sapiens OX=9606 GN=LMNB2 PE=1 SV=4" "0.000" "False" "16.674" "8" "6" "8" "4" "620" "69.9" "5.59" "23.08" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00038, Pf00932" "84823" "ENSG00000176619" "LMNB2" "hsa:84823; O75292; Q03252; Q14734; Q96DF6" "Gastric cancer network 2; Fas ligand pathway and stress induction of heat shock proteins; IL-18 signaling pathway; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "" "6" "0" "1.033" "1.194" "1.113" "1.145" "1.115" "1.273" "1.172" "1.294" "1.221" "110.3" "113.9" "131.6" "122.7" "126.2" "122.9" "140.3" "129.3" "142.7" "134.6" "" "" "" "" "" "" "" "" "" "" "66.0" "59.2" "72.9" "57.6" "58.5" "62.9" "65.2" "58.0" "77.4" "134.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8006254010702621328" "False" "High" "IsMasterProtein" "Cont_P08779" "Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4" "0.000" "True" "16.674" "13" "6" "14" "1" "473" "51.2" "5.05" "30.10" "6" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;cytosol;cytoskeleton" "cytoskeletal activity" "Pf00038" "3868" "ENSG00000186832" "KRT16" "A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8" "Vitamin D receptor pathway" "Formation of the cornified envelope" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "Not Found" "Not Found" "High" "Not Found" "High" "Not Found" "High" "1" "" "8611257715597886633" "False" "High" "IsMasterProtein" "Q15555" "Microtubule-associated protein RP/EB family member 2 OS=Homo sapiens OX=9606 GN=MAPRE2 PE=1 SV=1" "0.000" "False" "16.638" "13" "4" "6" "4" "327" "37.0" "5.57" "15.68" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf03271" "10982" "ENSG00000166974" "MAPRE2" "B2RE21; B3KR39; B4DJV4; B7Z2L3; E9PHR3; F5H1V8; G5E9I6; hsa:10982; Q15555; Q9UQ33" "Ciliary landscape" "" "1" "0" "1.056" "1.058" "1.133" "1.022" "0.956" "1.182" "0.131" "1.123" "14.310" "153.2" "161.7" "162.1" "173.6" "156.5" "146.4" "181.2" "20.1" "172.1" "2192.4" "" "" "" "" "" "" "" "" "" "" "91.7" "84.0" "89.8" "81.5" "72.6" "75.0" "84.2" "9.0" "93.3" "2192.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8387303708123169852" "False" "High" "IsMasterProtein" "P07602" "Prosaposin OS=Homo sapiens OX=9606 GN=PSAP PE=1 SV=2" "0.000" "False" "16.621" "7" "4" "10" "4" "524" "58.1" "5.17" "26.12" "4" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf02199, Pf03489, Pf05184" "5660" "ENSG00000197746" "PSAP" "hsa:5660; P07292; P07602; P15793; P78538; P78541; P78546; P78547; P78558; Q53Y86; Q6IBQ6; Q92739; Q92740; Q92741; Q92742" "Degradation pathway of sphingolipids, including diseases" "Neutrophil degranulation; G alpha (i) signalling events; Platelet degranulation ; Peptide ligand-binding receptors; Glycosphingolipid catabolism" "6" "0" "0.845" "0.895" "0.867" "1.005" "0.947" "1.217" "1.018" "0.953" "0.588" "694.1" "586.8" "620.9" "601.6" "697.2" "657.5" "844.4" "706.5" "661.4" "408.4" "" "" "" "" "" "" "" "" "" "" "415.4" "304.9" "343.8" "282.4" "323.2" "336.6" "392.6" "317.2" "358.8" "408.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5163980209620091115" "False" "High" "IsMasterProtein" "O43598" "5-hydroxymethyl-dUMP N-hydrolase OS=Homo sapiens OX=9606 GN=DNPH1 PE=1 SV=1" "0.000" "False" "16.573" "26" "3" "9" "3" "174" "19.1" "5.05" "27.37" "3" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05014" "10591" "ENSG00000112667" "DNPH1" "B2LUJ9; hsa:10591; O43598" "" "Purine catabolism" "1" "0" "0.879" "0.999" "1.019" "0.876" "0.969" "1.061" "0.939" "0.975" "0.526" "417.3" "367.0" "416.8" "425.3" "365.7" "404.5" "442.8" "391.8" "406.8" "219.4" "" "" "" "" "" "" "" "" "" "" "249.8" "190.7" "230.8" "199.7" "169.5" "207.1" "205.9" "175.9" "220.7" "219.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2753103137801597372" "False" "High" "IsMasterProtein" "Q99618" "Cell division cycle-associated protein 3 OS=Homo sapiens OX=9606 GN=CDCA3 PE=1 SV=1" "0.000" "False" "16.573" "25" "6" "7" "6" "268" "29.0" "6.43" "16.21" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "" "" "83461" "ENSG00000111665" "CDCA3" "A8K5V6; D3DUS6; hsa:83461; Q99618" "" "" "0" "0" "0.848" "0.906" "0.981" "1.021" "0.854" "1.245" "1.097" "1.174" "0.431" "271.9" "230.6" "246.4" "266.6" "277.5" "232.3" "338.4" "298.3" "319.1" "117.1" "" "" "" "" "" "" "" "" "" "" "162.7" "119.8" "136.5" "125.2" "128.6" "118.9" "157.4" "133.9" "173.1" "117.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8633785530779633839" "False" "High" "IsMasterProtein" "P49354" "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha OS=Homo sapiens OX=9606 GN=FNTA PE=1 SV=1" "0.000" "False" "16.565" "13" "5" "11" "5" "379" "44.4" "5.08" "20.98" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf01239" "2339" "ENSG00000168522" "FNTA" "A6NJW0; hsa:2339; P49354; Q53XJ9; Q9UDC1" "Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "Potential therapeutics for SARS; Inactivation, recovery and regulation of the phototransduction cascade; RAS processing; Apoptotic cleavage of cellular proteins" "9" "0" "1.042" "1.010" "0.946" "1.005" "0.905" "0.998" "1.058" "0.941" "0.826" "374.5" "390.2" "378.3" "354.2" "376.3" "338.7" "373.5" "396.3" "352.2" "309.2" "" "" "" "" "" "" "" "" "" "" "224.1" "202.7" "209.5" "166.3" "174.4" "173.4" "173.7" "177.9" "191.1" "309.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1701299476432316153" "False" "High" "IsMasterProtein" "Q9BU61" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 OS=Homo sapiens OX=9606 GN=NDUFAF3 PE=1 SV=1" "0.000" "False" "16.562" "32" "4" "4" "4" "184" "20.3" "8.22" "10.27" "4" "cell organization and biogenesis" "other membranes;mitochondrion;nucleus" "" "Pf04430" "25915" "ENSG00000178057" "NDUFAF3" "hsa:25915; Q9BU61" "" "Complex I biogenesis" "1" "0" "0.836" "0.878" "0.960" "1.076" "0.902" "0.886" "1.156" "0.889" "0.683" "128.6" "107.5" "112.8" "123.5" "138.4" "116.0" "113.9" "148.6" "114.2" "87.8" "" "" "" "" "" "" "" "" "" "" "76.9" "55.9" "62.5" "58.0" "64.1" "59.4" "53.0" "66.7" "62.0" "87.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1056370544189754053" "False" "High" "IsMasterProtein" "P28065" "Proteasome subunit beta type-9 OS=Homo sapiens OX=9606 GN=PSMB9 PE=1 SV=2" "0.000" "False" "16.536" "23" "4" "8" "4" "219" "23.3" "5.03" "21.49" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227" "5698" "ENSG00000239836; ENSG00000240065; ENSG00000240118; ENSG00000240508; ENSG00000242711; ENSG00000243067; ENSG00000243594; ENSG00000243958" "PSMB9" "B0V0T1; hsa:5698; P28065; Q16523; Q5JNW4" "Proteasome degradation; Type II interferon signaling" "Separation of Sister Chromatids; Downstream TCR signaling; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "61" "0" "1.040" "0.982" "1.181" "1.126" "1.007" "1.100" "1.048" "1.060" "0.960" "293.7" "305.5" "288.3" "346.8" "330.7" "295.6" "323.1" "307.7" "311.4" "282.0" "" "" "" "" "" "" "" "" "" "" "175.8" "158.7" "159.7" "162.8" "153.3" "151.3" "150.3" "138.2" "168.9" "282.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3180744532399736086" "False" "High" "IsMasterProtein" "Q15814" "Tubulin-specific chaperone C OS=Homo sapiens OX=9606 GN=TBCC PE=1 SV=2" "0.000" "False" "16.527" "16" "7" "7" "6" "346" "39.2" "5.71" "15.08" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf07986, Pf16752" "6903" "ENSG00000124659" "TBCC" "hsa:6903; Q15814; Q53Y43; Q5T787" "" "Post-chaperonin tubulin folding pathway" "1" "0" "1.126" "0.949" "1.029" "1.145" "1.061" "1.102" "0.951" "1.066" "1.565" "304.5" "342.8" "289.0" "313.3" "348.7" "322.9" "335.7" "289.5" "324.7" "476.5" "" "" "" "" "" "" "" "" "" "" "182.2" "178.1" "160.1" "147.1" "161.6" "165.3" "156.1" "130.0" "176.2" "476.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3906185605223521012" "False" "High" "IsMasterProtein" "Q9BY32" "Inosine triphosphate pyrophosphatase OS=Homo sapiens OX=9606 GN=ITPA PE=1 SV=2" "0.000" "False" "16.503" "35" "5" "17" "5" "194" "21.4" "5.66" "33.40" "5" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01725" "3704" "ENSG00000125877" "ITPA" "A2A2N2; A4UIM5; B2BCH7; hsa:3704; O14878; Q5JWH4; Q9BY32; Q9BYN1; Q9BYX0; Q9H3H8" "" "Purine catabolism; Ribavirin ADME" "2" "0" "1.022" "1.047" "1.074" "1.008" "0.931" "0.813" "1.042" "0.930" "0.590" "227.9" "232.8" "238.5" "244.8" "229.7" "212.1" "185.2" "237.4" "212.0" "134.6" "" "" "" "" "" "" "" "" "" "" "136.4" "121.0" "132.1" "114.9" "106.5" "108.6" "86.1" "106.6" "115.0" "134.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7973813700341614243" "False" "High" "IsMasterProtein" "Q96SB4" "SRSF protein kinase 1 OS=Homo sapiens OX=9606 GN=SRPK1 PE=1 SV=2" "0.000" "False" "16.464" "8" "5" "6" "5" "655" "74.3" "6.16" "12.23" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6732" "ENSG00000096063" "SRPK1" "B4DS61; hsa:6732; Q12890; Q5R364; Q5R365; Q8IY12; Q96SB4" "VEGFA-VEGFR2 signaling; mRNA processing" "Replacement of protamines by nucleosomes in the male pronucleus; Maturation of nucleoprotein" "4" "0" "0.966" "0.848" "1.283" "1.288" "1.216" "1.122" "1.107" "1.119" "1.241" "41.6" "40.2" "35.3" "53.4" "53.6" "50.6" "46.7" "46.1" "46.6" "51.7" "" "" "" "" "" "" "" "" "" "" "24.9" "20.9" "19.6" "25.1" "24.9" "25.9" "21.7" "20.7" "25.3" "51.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7944368975479606522" "False" "High" "IsMasterProtein" "O94979" "Protein transport protein Sec31A OS=Homo sapiens OX=9606 GN=SEC31A PE=1 SV=3" "0.000" "False" "16.430" "5" "6" "9" "6" "1220" "132.9" "6.89" "19.93" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf12931" "22872" "ENSG00000138674" "SEC31A" "B4DIW6; B7ZKZ7; B7ZL00; H7C2W3; hsa:22872; O94979; Q17RR5; Q5H9P6; Q5XG74; Q659G7; Q6ZU90; Q7LCX9; Q86TJ0; Q8IZH4; Q9P048; Q9P0A6; Q9UM05; Q9UM06" "Sterol regulatory element-binding proteins (SREBP) signaling" "Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "6" "0" "0.975" "1.088" "1.376" "1.163" "1.004" "1.125" "0.960" "1.268" "2.881" "96.9" "94.5" "105.4" "133.3" "112.6" "97.3" "109.0" "93.0" "122.9" "279.1" "" "" "" "" "" "" "" "" "" "" "58.0" "49.1" "58.4" "62.6" "52.2" "49.8" "50.7" "41.8" "66.7" "279.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3629072451512354259" "False" "High" "IsMasterProtein" "P52701" "DNA mismatch repair protein Msh6 OS=Homo sapiens OX=9606 GN=MSH6 PE=1 SV=2" "0.000" "False" "16.429" "3" "5" "6" "5" "1360" "152.7" "6.90" "12.91" "5" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00488, Pf00855, Pf01624, Pf05188, Pf05190, Pf05192" "2956" "ENSG00000116062" "MSH6" "B4DF41; B4E3I4; F5H2F9; hsa:2956; O43706; O43917; P52701; Q8TCX4; Q9BTB5" "Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Chromosomal and microsatellite instability in colorectal cancer ; DNA repair pathways, full network; DNA mismatch repair" "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6" "8" "0" "1.044" "1.044" "1.262" "1.216" "1.103" "1.093" "0.421" "1.220" "8.992" "179.1" "187.0" "187.0" "226.0" "217.8" "197.6" "195.8" "75.5" "218.6" "1610.8" "" "" "" "" "" "" "" "" "" "" "107.2" "97.2" "103.6" "106.1" "101.0" "101.2" "91.0" "33.9" "118.6" "1610.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-849081801659546262" "False" "High" "IsMasterProtein" "P30533" "Alpha-2-macroglobulin receptor-associated protein OS=Homo sapiens OX=9606 GN=LRPAP1 PE=1 SV=1" "0.000" "False" "16.418" "14" "4" "5" "4" "357" "41.4" "8.78" "18.85" "4" "transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf06400, Pf06401" "4043" "ENSG00000163956" "LRPAP1" "D3DVR9; hsa:4043; P30533; Q2M310; Q53HQ3; Q53HS6" "Cholesterol metabolism" "" "1" "0" "0.966" "0.901" "1.023" "1.019" "0.934" "1.185" "1.185" "1.092" "0.472" "286.3" "276.6" "257.9" "292.9" "291.8" "267.5" "339.4" "339.4" "312.5" "135.2" "" "" "" "" "" "" "" "" "" "" "171.3" "143.7" "142.8" "137.5" "135.3" "137.0" "157.8" "152.4" "169.6" "135.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "215729870143927910" "False" "High" "IsMasterProtein" "P52815" "Large ribosomal subunit protein bL12m OS=Homo sapiens OX=9606 GN=MRPL12 PE=1 SV=2" "0.000" "False" "16.415" "13" "2" "5" "2" "198" "21.3" "8.87" "14.69" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00542, Pf16320" "6182" "ENSG00000262814" "MRPL12" "hsa:6182; P52815; Q969U0; Q9HCA2; Q9UQJ3" "" "Mitochondrial protein degradation; Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "0.966" "0.966" "0.951" "1.200" "1.074" "1.110" "1.153" "1.241" "0.803" "341.3" "329.6" "329.6" "324.6" "409.7" "366.7" "378.9" "393.6" "423.5" "274.1" "" "" "" "" "" "" "" "" "" "" "204.3" "171.3" "182.5" "152.4" "189.9" "187.7" "176.2" "176.7" "229.8" "274.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4501130865097894528" "False" "High" "IsMasterProtein" "O60763" "General vesicular transport factor p115 OS=Homo sapiens OX=9606 GN=USO1 PE=1 SV=2" "0.000" "False" "16.355" "5" "4" "4" "4" "962" "107.8" "4.91" "13.59" "4" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "" "Pf04869, Pf04871, Pf18770" "8615" "ENSG00000138768" "USO1" "B2RAQ0; hsa:8615; O60763; Q6PK63; Q86TB8; Q8N592" "" "COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization" "3" "0" "1.695" "2.040" "2.197" "1.394" "1.384" "1.873" "1.631" "1.458" "8.111" "25.1" "42.5" "51.1" "55.1" "34.9" "34.7" "46.9" "40.9" "36.5" "203.2" "" "" "" "" "" "" "" "" "" "" "15.0" "22.1" "28.3" "25.8" "16.2" "17.8" "21.8" "18.3" "19.8" "203.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7950271419257628424" "False" "High" "IsMasterProtein" "P30049" "ATP synthase subunit delta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1D PE=1 SV=2" "0.000" "False" "16.354" "14" "2" "6" "2" "168" "17.5" "5.49" "20.56" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf02823, Pf21335" "513" "ENSG00000099624" "ATP5F1D" "D6W5Y3; hsa:513; P30049; Q6FG90" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Cristae formation; Formation of ATP by chemiosmotic coupling" "5" "0" "1.031" "0.876" "0.961" "1.110" "0.916" "1.045" "1.101" "0.987" "0.451" "275.0" "283.6" "241.0" "264.4" "305.2" "251.9" "287.4" "302.7" "271.4" "124.1" "" "" "" "" "" "" "" "" "" "" "164.6" "147.4" "133.5" "124.1" "141.5" "128.9" "133.6" "135.9" "147.2" "124.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4622690060897357887" "False" "High" "IsMasterProtein" "Q9UII2" "ATPase inhibitor, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5IF1 PE=1 SV=1" "0.000" "False" "16.335" "35" "4" "28" "4" "106" "12.2" "9.35" "60.68" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf04568" "93974" "ENSG00000130770; ENSG00000285390" "ATP5IF1" "hsa:93974; Q5JXL8; Q6IAQ7; Q9BSL9; Q9UII2" "Electron transport chain: OXPHOS system in mitochondria" "" "1" "0" "0.922" "0.947" "0.888" "1.015" "0.952" "0.995" "1.070" "0.862" "0.445" "2256.0" "2079.2" "2135.8" "2003.7" "2289.5" "2146.8" "2244.1" "2414.4" "1944.0" "1004.1" "" "" "" "" "" "" "" "" "" "" "1350.1" "1080.5" "1182.7" "940.7" "1061.2" "1099.0" "1043.5" "1083.9" "1054.7" "1004.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-242309002880936469" "False" "High" "IsMasterProtein" "Q8NI27" "THO complex subunit 2 OS=Homo sapiens OX=9606 GN=THOC2 PE=1 SV=2" "0.000" "False" "16.319" "3" "5" "6" "5" "1593" "182.7" "8.44" "14.32" "5" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf11262, Pf11732, Pf16134" "57187" "ENSG00000125676" "THOC2" "A6NM50; hsa:57187; Q5JZ12; Q6IN92; Q8NI27; Q9H8I6" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "0.869" "0.945" "0.922" "0.992" "0.917" "0.782" "0.534" "0.858" "4.263" "170.6" "148.2" "161.2" "157.3" "169.3" "156.5" "133.4" "91.2" "146.5" "727.5" "" "" "" "" "" "" "" "" "" "" "102.1" "77.0" "89.3" "73.9" "78.5" "80.1" "62.0" "40.9" "79.5" "727.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6256395688163039861" "False" "High" "IsMasterProtein" "O75643" "U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Homo sapiens OX=9606 GN=SNRNP200 PE=1 SV=2" "0.000" "False" "16.311" "3" "7" "7" "7" "2136" "244.4" "6.06" "14.11" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf02889, Pf18149, Pf21188" "23020" "ENSG00000144028" "SNRNP200" "hsa:23020; O75643; O94884; Q6NZY0; Q6PX59; Q8NBE6; Q96IF2; Q9H7S0" "2q11.2 copy number variation syndrome" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "1.134" "1.144" "1.073" "1.032" "1.125" "1.213" "0.983" "1.215" "2.502" "110.4" "125.2" "126.4" "118.5" "114.0" "124.3" "133.9" "108.5" "134.2" "276.4" "" "" "" "" "" "" "" "" "" "" "66.1" "65.1" "70.0" "55.6" "52.8" "63.6" "62.3" "48.7" "72.8" "276.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2645630736488314632" "False" "High" "IsMasterProtein" "P04080" "Cystatin-B OS=Homo sapiens OX=9606 GN=CSTB PE=1 SV=2" "0.000" "False" "16.298" "24" "2" "14" "2" "98" "11.1" "7.56" "49.75" "2" "other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00031" "1476" "ENSG00000160213" "CSTB" "hsa:1476; P04080" "" "Neutrophil degranulation" "1" "0" "0.905" "0.943" "0.866" "0.907" "1.032" "0.790" "1.087" "0.926" "0.600" "1118.1" "1011.4" "1054.4" "967.8" "1014.4" "1154.3" "882.9" "1215.2" "1034.8" "671.4" "" "" "" "" "" "" "" "" "" "" "669.1" "525.6" "583.9" "454.4" "470.2" "590.9" "410.5" "545.5" "561.4" "671.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6259860464076082435" "False" "High" "IsMasterProtein" "Q9NR31" "Small COPII coat GTPase SAR1A OS=Homo sapiens OX=9606 GN=SAR1A PE=1 SV=1" "0.000" "False" "16.292" "16" "3" "9" "1" "198" "22.4" "6.68" "20.66" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00025" "56681" "ENSG00000079332" "SAR1A" "B4DQ19; hsa:56681; Q9NR31" "Sterol regulatory element-binding proteins (SREBP) signaling" "" "1" "0" "1.060" "0.799" "1.572" "1.338" "0.946" "1.320" "1.228" "0.836" "0.998" "168.9" "179.0" "134.9" "265.5" "226.1" "159.8" "222.9" "207.4" "141.2" "168.6" "" "" "" "" "" "" "" "" "" "" "101.1" "93.0" "74.7" "124.7" "104.8" "81.8" "103.7" "93.1" "76.6" "168.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7053379414769105992" "False" "High" "IsMasterProtein" "Q92905" "COP9 signalosome complex subunit 5 OS=Homo sapiens OX=9606 GN=COPS5 PE=1 SV=4" "0.000" "False" "16.289" "24" "7" "13" "7" "334" "37.6" "6.54" "25.30" "7" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf18323" "10987" "ENSG00000121022" "COPS5" "hsa:10987; O15386; Q6AW95; Q86WQ4; Q92905; Q9BQ17" "TGF-beta signaling pathway" "Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; Neddylation; DNA Damage Recognition in GG-NER" "5" "0" "1.036" "0.966" "1.059" "1.075" "0.981" "1.143" "1.093" "1.073" "0.861" "488.3" "505.8" "471.7" "517.0" "524.7" "478.9" "557.9" "533.6" "523.7" "420.6" "" "" "" "" "" "" "" "" "" "" "292.2" "262.9" "261.2" "242.7" "243.2" "245.2" "259.4" "239.5" "284.1" "420.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4784462983212685670" "False" "High" "IsMasterProtein" "Q96KP4" "Cytosolic non-specific dipeptidase OS=Homo sapiens OX=9606 GN=CNDP2 PE=1 SV=2" "0.000" "False" "16.249" "9" "5" "11" "5" "475" "52.8" "5.97" "27.41" "5" "protein metabolism" "cytosol;nucleus" "other molecular function" "Pf01546, Pf07687" "55748" "ENSG00000133313" "CNDP2" "B3KUG4; hsa:55748; Q8WY59; Q96KP4; Q9BQ94; Q9NVB4; V9HWE5" "" "Glutathione synthesis and recycling; Paracetamol ADME" "2" "0" "1.037" "0.975" "1.016" "0.934" "0.785" "1.114" "0.812" "1.004" "1.706" "561.9" "582.7" "547.8" "571.1" "524.7" "441.0" "626.1" "456.5" "563.9" "958.4" "" "" "" "" "" "" "" "" "" "" "336.3" "302.8" "303.4" "268.1" "243.2" "225.7" "291.1" "204.9" "306.0" "958.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-377515032386624778" "False" "High" "IsMasterProtein" "P78346" "Ribonuclease P protein subunit p30 OS=Homo sapiens OX=9606 GN=RPP30 PE=1 SV=1" "0.000" "False" "16.226" "15" "3" "4" "3" "268" "29.3" "8.91" "14.24" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01876" "10556" "ENSG00000148688" "RPP30" "B2R799; E9PB02; hsa:10556; P78346" "" "Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus" "2" "0" "0.988" "1.030" "1.085" "1.098" "1.112" "1.095" "1.129" "1.070" "0.999" "236.6" "233.8" "243.8" "256.7" "259.9" "263.0" "259.0" "267.1" "253.2" "236.4" "" "" "" "" "" "" "" "" "" "" "141.6" "121.5" "135.0" "120.5" "120.5" "134.6" "120.4" "119.9" "137.4" "236.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2601253202356678168" "False" "High" "IsMasterProtein" "P31937" "3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HIBADH PE=1 SV=2" "0.000" "False" "16.220" "19" "4" "6" "4" "336" "35.3" "8.13" "17.83" "4" "other metabolic processes" "mitochondrion" "other molecular function" "Pf03446, Pf14833" "11112" "ENSG00000106049" "HIBADH" "hsa:11112; P31937; Q546Z2; Q9UDN3" "Amino acid metabolism" "Branched-chain amino acid catabolism" "2" "0" "1.045" "1.070" "1.016" "1.016" "1.040" "1.381" "1.032" "0.981" "1.299" "54.5" "57.0" "58.3" "55.4" "55.4" "56.7" "75.3" "56.3" "53.5" "70.9" "" "" "" "" "" "" "" "" "" "" "32.6" "29.6" "32.3" "26.0" "25.7" "29.0" "35.0" "25.3" "29.0" "70.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7224643183628006691" "False" "High" "IsMasterProtein" "O00303" "Eukaryotic translation initiation factor 3 subunit F OS=Homo sapiens OX=9606 GN=EIF3F PE=1 SV=1" "0.000" "False" "16.186" "13" "4" "5" "4" "357" "37.5" "5.45" "12.00" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf13012" "8665" "ENSG00000175390" "EIF3F" "A8K0S2; hsa:8665; O00303; Q6IB45; Q8N978" "Translation factors; VEGFA-VEGFR2 signaling; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "9" "0" "1.093" "1.132" "1.320" "1.212" "1.175" "1.227" "0.986" "1.260" "3.795" "166.3" "181.7" "188.3" "219.5" "201.5" "195.3" "204.0" "164.0" "209.6" "631.1" "" "" "" "" "" "" "" "" "" "" "99.5" "94.4" "104.3" "103.0" "93.4" "100.0" "94.8" "73.6" "113.7" "631.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "32097797701443302" "False" "High" "IsMasterProtein" "Q14008" "Cytoskeleton-associated protein 5 OS=Homo sapiens OX=9606 GN=CKAP5 PE=1 SV=3" "0.000" "False" "16.173" "2" "5" "5" "5" "2032" "225.4" "7.80" "14.93" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02985, Pf12348, Pf21041" "9793" "ENSG00000175216" "CKAP5" "hsa:9793; Q05D70; Q0VAX7; Q0VAX8; Q14008; Q14668; Q2TA89; Q6NSH4" "4p16.3 copy number variation" "Separation of Sister Chromatids; Regulation of PLK1 Activity at G2/M Transition; RHO GTPases Activate Formins; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; EML4 and NUDC in mitotic spindle formation; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "14" "0" "1.024" "1.006" "1.226" "1.162" "0.973" "1.068" "0.711" "0.882" "5.504" "48.7" "49.8" "49.0" "59.7" "56.5" "47.3" "52.0" "34.6" "42.9" "267.8" "" "" "" "" "" "" "" "" "" "" "29.1" "25.9" "27.1" "28.0" "26.2" "24.2" "24.2" "15.5" "23.3" "267.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8719545438223687688" "False" "High" "IsMasterProtein" "Q9NWV8" "BRISC and BRCA1-A complex member 1 OS=Homo sapiens OX=9606 GN=BABAM1 PE=1 SV=1" "0.000" "False" "16.168" "13" "3" "5" "3" "329" "36.5" "4.64" "14.57" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "" "29086" "ENSG00000105393" "BABAM1" "A8MQT0; B4DRY9; B4DVR1; hsa:29086; Q6FIA0; Q9NWV8; Q9P018" "5q35 copy number variation" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "6" "0" "1.148" "1.049" "1.211" "1.023" "0.990" "1.111" "0.972" "1.132" "1.002" "166.6" "191.2" "174.8" "201.7" "170.4" "164.8" "185.0" "161.9" "188.6" "166.8" "" "" "" "" "" "" "" "" "" "" "99.7" "99.4" "96.8" "94.7" "79.0" "84.4" "86.0" "72.7" "102.3" "166.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5080369595642031285" "False" "High" "IsMasterProtein" "Q9BVG4" "Protein PBDC1 OS=Homo sapiens OX=9606 GN=PBDC1 PE=1 SV=1" "0.000" "False" "16.164" "20" "4" "5" "4" "233" "26.0" "4.79" "14.41" "4" "" "" "" "Pf04669" "51260" "ENSG00000102390" "PBDC1" "hsa:51260; Q9BVG4" "" "" "0" "0" "1.128" "0.871" "1.141" "1.086" "0.879" "1.110" "1.029" "1.154" "2.434" "144.6" "163.2" "125.9" "165.0" "157.0" "127.1" "160.5" "148.8" "166.9" "351.9" "" "" "" "" "" "" "" "" "" "" "86.5" "84.8" "69.7" "77.5" "72.8" "65.0" "74.6" "66.8" "90.6" "351.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8796563562417500540" "False" "High" "IsMasterProtein" "P51532" "Transcription activator BRG1 OS=Homo sapiens OX=9606 GN=SMARCA4 PE=1 SV=2" "0.000" "False" "16.153" "3" "4" "4" "4" "1647" "184.5" "7.88" "12.40" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf14619" "6597" "ENSG00000127616" "SMARCA4" "B1A8Z4; B1A8Z5; B1A8Z6; B1A8Z7; E9PBR8; hsa:6597; O95052; P51532; Q9HBD3" "Androgen receptor network in prostate cancer; Pre-implantation embryo; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Tumor suppressor activity of SMARCB1; Rett syndrome; Thermogenesis; Kleefstra syndrome" "Formation of the beta-catenin:TCF transactivating complex; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Interleukin-7 signaling; RMTs methylate histone arginines; EGR2 and SOX10-mediated initiation of Schwann cell myelination" "13" "0" "0.989" "1.013" "1.242" "1.289" "1.128" "1.159" "0.922" "0.995" "2.446" "66.2" "65.4" "67.0" "82.2" "85.3" "74.6" "76.7" "61.0" "65.9" "161.9" "" "" "" "" "" "" "" "" "" "" "39.6" "34.0" "37.1" "38.6" "39.6" "38.2" "35.7" "27.4" "35.7" "161.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6550652705279003104" "False" "High" "IsMasterProtein" "P50552" "Vasodilator-stimulated phosphoprotein OS=Homo sapiens OX=9606 GN=VASP PE=1 SV=3" "0.000" "False" "16.099" "20" "6" "6" "6" "380" "39.8" "8.94" "11.15" "6" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "7408" "ENSG00000125753" "VASP" "B2RBT9; hsa:7408; P50552; Q6PIZ1; Q93035" "Integrin-mediated cell adhesion; Focal adhesion" "Generation of second messenger molecules; Signaling by ROBO receptors; Cell-extracellular matrix interactions" "5" "0" "1.180" "1.020" "1.199" "1.119" "1.031" "1.236" "0.788" "0.969" "4.845" "96.5" "113.9" "98.4" "115.7" "108.0" "99.5" "119.3" "76.1" "93.6" "467.7" "" "" "" "" "" "" "" "" "" "" "57.8" "59.2" "54.5" "54.3" "50.1" "50.9" "55.5" "34.2" "50.8" "467.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8568464795180105445" "False" "High" "IsMasterProtein" "Q9Y385" "Ubiquitin-conjugating enzyme E2 J1 OS=Homo sapiens OX=9606 GN=UBE2J1 PE=1 SV=2" "0.000" "False" "16.095" "9" "2" "4" "2" "318" "35.2" "6.74" "15.34" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf00179" "51465" "ENSG00000198833" "UBE2J1" "A8K3F9; hsa:51465; Q53F25; Q5W0N4; Q9BZ32; Q9NQL3; Q9NY66; Q9P011; Q9P0S0; Q9UF10; Q9Y385" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "Antigen processing: Ubiquitination & Proteasome degradation" "3" "0" "1.049" "1.712" "1.121" "1.123" "0.799" "1.559" "0.413" "1.072" "6.432" "16.0" "16.8" "27.4" "17.9" "18.0" "12.8" "24.9" "6.6" "17.1" "102.8" "" "" "" "" "" "" "" "" "" "" "9.6" "8.7" "15.1" "8.4" "8.3" "6.5" "11.6" "3.0" "9.3" "102.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1957491016862499710" "False" "High" "IsMasterProtein" "P13073" "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Homo sapiens OX=9606 GN=COX4I1 PE=1 SV=1" "0.000" "False" "16.019" "24" "4" "6" "4" "169" "19.6" "9.51" "17.27" "4" "other metabolic processes;transport" "other membranes;cytosol;mitochondrion;nucleus" "transporter activity" "Pf02936" "1327" "ENSG00000131143" "COX4I1" "B2R4J2; D3DUM7; hsa:1327; P13073; Q6P666" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial protein degradation" "8" "0" "1.014" "1.012" "0.935" "1.134" "1.149" "1.081" "1.140" "0.996" "0.613" "556.1" "563.9" "562.8" "520.1" "630.6" "639.1" "601.3" "633.7" "553.9" "340.7" "" "" "" "" "" "" "" "" "" "" "332.8" "293.0" "311.6" "244.2" "292.3" "327.2" "279.6" "284.5" "300.5" "340.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5761790178817742854" "False" "High" "IsMasterProtein" "Q96P70" "Importin-9 OS=Homo sapiens OX=9606 GN=IPO9 PE=1 SV=3" "0.000" "False" "16.010" "5" "6" "6" "6" "1041" "115.9" "4.81" "15.05" "6" "transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03810" "55705" "ENSG00000198700" "IPO9" "B1ASV5; hsa:55705; Q8N1Y1; Q8N3I2; Q8NCG9; Q96P70; Q96SU6; Q9NW01; Q9P0A8; Q9ULM8" "" "" "0" "0" "1.446" "1.191" "1.020" "0.849" "1.117" "1.099" "0.793" "0.703" "2.142" "20.2" "29.3" "24.1" "20.6" "17.2" "22.6" "22.3" "16.0" "14.2" "43.4" "" "" "" "" "" "" "" "" "" "" "12.1" "15.2" "13.4" "9.7" "8.0" "11.6" "10.3" "7.2" "7.7" "43.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5381217781487520932" "False" "High" "IsMasterProtein" "Q99536" "Synaptic vesicle membrane protein VAT-1 homolog OS=Homo sapiens OX=9606 GN=VAT1 PE=1 SV=2" "0.000" "False" "16.007" "11" "3" "5" "3" "393" "41.9" "6.29" "14.94" "3" "other biological processes" "non-structural extracellular;other membranes;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf08240, Pf13602" "10493" "ENSG00000108828" "VAT1" "A8K345; B0AZP7; B4DPX4; hsa:10493; Q13035; Q5BKZ7; Q96A39; Q99536; Q9BUT8" "" "Neutrophil degranulation" "1" "0" "0.944" "0.999" "1.057" "1.060" "1.004" "0.958" "1.158" "1.042" "0.759" "176.0" "166.2" "175.8" "186.1" "186.6" "176.7" "168.7" "203.9" "183.4" "133.6" "" "" "" "" "" "" "" "" "" "" "105.3" "86.4" "97.3" "87.4" "86.5" "90.5" "78.4" "91.5" "99.5" "133.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4549741875275556482" "False" "High" "IsMasterProtein" "Q99627" "COP9 signalosome complex subunit 8 OS=Homo sapiens OX=9606 GN=COPS8 PE=1 SV=1" "0.000" "False" "16.002" "17" "2" "5" "2" "209" "23.2" "5.38" "16.40" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10075" "10920" "ENSG00000198612" "COPS8" "A8K1H6; hsa:10920; Q53QS9; Q99627" "Ciliary landscape; 2q37 copy number variation syndrome" "Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER" "6" "0" "0.940" "0.785" "0.892" "0.886" "0.963" "0.990" "0.873" "0.864" "0.609" "275.4" "258.8" "216.3" "245.7" "244.1" "265.1" "272.5" "240.4" "237.9" "167.7" "" "" "" "" "" "" "" "" "" "" "164.8" "134.5" "119.8" "115.4" "113.1" "135.7" "126.7" "107.9" "129.1" "167.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7726317818688943966" "False" "High" "IsMasterProtein" "Q9NQC3" "Reticulon-4 OS=Homo sapiens OX=9606 GN=RTN4 PE=1 SV=2" "0.000" "False" "16.001" "5" "5" "6" "5" "1192" "129.9" "4.50" "9.76" "5" "cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02453" "57142" "ENSG00000115310" "RTN4" "O94962; Q7L7Q5; Q7L7Q6; Q7L7Q8; Q8IUA4; Q96B16; Q9BXG5; Q9H212; Q9H3I3; Q9NQC3; Q9UQ42; Q9Y293; Q9Y2Y7; Q9Y5U6" "Alzheimer's disease and miRNA effects; Spinal cord injury; 22q11.2 copy number variation syndrome; Alzheimer's disease; Neurogenesis regulation in the olfactory epithelium; 13q12.12 copy number variation" "Axonal growth inhibition (RHOA activation)" "7" "0" "1.086" "1.049" "0.856" "1.199" "0.875" "0.957" "1.112" "1.048" "0.518" "118.9" "129.2" "124.7" "101.8" "142.5" "104.1" "113.7" "132.2" "124.6" "61.6" "" "" "" "" "" "" "" "" "" "" "71.2" "67.1" "69.1" "47.8" "66.1" "53.3" "52.9" "59.4" "67.6" "61.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3208600518816650541" "False" "High" "IsMasterProtein" "Q96IU4" "Putative protein-lysine deacylase ABHD14B OS=Homo sapiens OX=9606 GN=ABHD14B PE=1 SV=1" "0.000" "False" "15.972" "22" "4" "4" "4" "210" "22.3" "6.40" "13.17" "4" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12697" "84836" "ENSG00000114779" "ABHD14B" "hsa:84836; Q86VK8; Q8N8W5; Q96IU4" "" "Cytosolic sulfonation of small molecules" "1" "0" "0.965" "0.991" "0.911" "1.095" "1.080" "1.144" "1.088" "1.043" "1.010" "191.9" "185.2" "190.3" "174.8" "210.2" "207.2" "219.6" "208.9" "200.2" "193.8" "" "" "" "" "" "" "" "" "" "" "114.8" "96.2" "105.4" "82.1" "97.4" "106.1" "102.1" "93.8" "108.6" "193.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5381305641147496779" "False" "High" "IsMasterProtein" "Q9HAV7" "GrpE protein homolog 1, mitochondrial OS=Homo sapiens OX=9606 GN=GRPEL1 PE=1 SV=2" "0.000" "False" "15.959" "26" "6" "11" "6" "217" "24.3" "8.12" "27.19" "6" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf01025" "80273" "ENSG00000109519" "GRPEL1" "B2R783; hsa:80273; Q549M6; Q9HAV7" "" "Mitochondrial protein import" "1" "0" "1.028" "1.169" "1.155" "1.162" "1.291" "1.149" "1.037" "1.076" "1.868" "517.0" "531.7" "604.2" "596.9" "600.5" "667.4" "594.0" "536.1" "556.1" "965.9" "" "" "" "" "" "" "" "" "" "" "309.4" "276.3" "334.6" "280.2" "278.4" "341.6" "276.2" "240.7" "301.7" "965.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7653373487496169859" "False" "High" "IsMasterProtein" "Q4VC05" "B-cell CLL/lymphoma 7 protein family member A OS=Homo sapiens OX=9606 GN=BCL7A PE=1 SV=1" "0.000" "False" "15.956" "40" "6" "9" "6" "210" "22.8" "5.14" "18.06" "6" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf04714" "605" "ENSG00000110987" "BCL7A" "B4DJN6; B7ZB21; hsa:605; Q13843; Q14CT7; Q4VC05" "" "" "0" "0" "0.848" "0.881" "0.924" "0.959" "0.917" "0.835" "1.026" "0.916" "0.887" "312.9" "265.3" "275.8" "289.0" "299.9" "286.8" "261.3" "320.9" "286.6" "277.7" "" "" "" "" "" "" "" "" "" "" "187.2" "137.9" "152.7" "135.7" "139.0" "146.8" "121.5" "144.1" "155.5" "277.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8760607610450426056" "False" "High" "IsMasterProtein" "P35251" "Replication factor C subunit 1 OS=Homo sapiens OX=9606 GN=RFC1 PE=1 SV=4" "0.000" "False" "15.942" "4" "4" "6" "4" "1148" "128.2" "9.36" "14.57" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00004, Pf00533, Pf08519" "5981" "ENSG00000035928" "RFC1" "A8K6E7; hsa:5981; P35251; Q5XKF5; Q6PKU0; Q86V41; Q86V46" "miRNA regulation of DNA damage response; DNA replication; Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair; DNA damage response" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "22" "0" "1.098" "1.085" "0.980" "1.028" "1.006" "1.046" "0.846" "1.048" "1.964" "64.5" "70.8" "70.0" "63.2" "66.3" "64.9" "67.4" "54.5" "67.6" "126.7" "" "" "" "" "" "" "" "" "" "" "38.6" "36.8" "38.7" "29.7" "30.7" "33.2" "31.4" "24.5" "36.7" "126.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8485182549121438413" "False" "High" "IsMasterProtein" "O14776" "Transcription elongation regulator 1 OS=Homo sapiens OX=9606 GN=TCERG1 PE=1 SV=2" "0.000" "False" "15.934" "7" "8" "9" "8" "1098" "123.8" "8.65" "14.79" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00397, Pf01846" "10915" "ENSG00000113649" "TCERG1" "hsa:10915; O14776; Q2NKN2; Q59EA1" "" "mRNA Splicing - Major Pathway" "1" "0" "0.969" "1.271" "1.384" "0.988" "1.026" "1.204" "0.820" "1.133" "5.132" "96.4" "93.5" "122.5" "133.5" "95.3" "98.9" "116.1" "79.0" "109.2" "494.8" "" "" "" "" "" "" "" "" "" "" "57.7" "48.6" "67.8" "62.7" "44.2" "50.6" "54.0" "35.5" "59.3" "494.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6598258105920115633" "False" "High" "IsMasterProtein" "Q5TDH0" "Protein DDI1 homolog 2 OS=Homo sapiens OX=9606 GN=DDI2 PE=1 SV=1" "0.000" "False" "15.934" "13" "5" "8" "5" "399" "44.5" "5.05" "18.66" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf09668" "84301" "ENSG00000197312" "DDI2" "A8KAE1; hsa:84301; Q5TDH0; Q7RTZ0; Q9BRT1" "" "" "0" "0" "1.118" "0.918" "1.094" "1.064" "0.886" "1.054" "0.795" "0.887" "1.243" "281.5" "314.7" "258.3" "307.9" "299.6" "249.2" "296.5" "223.6" "249.5" "349.9" "" "" "" "" "" "" "" "" "" "" "168.4" "163.5" "143.0" "144.5" "138.9" "127.6" "137.9" "100.4" "135.4" "349.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1614464300928510251" "False" "High" "IsMasterProtein" "P55854" "Small ubiquitin-related modifier 3 OS=Homo sapiens OX=9606 GN=SUMO3 PE=1 SV=2" "0.000" "False" "15.914" "20" "2" "13" "1" "103" "11.6" "5.49" "47.72" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11976" "6612" "ENSG00000184900" "SUMO3" "B2R5X4; B4DUW4; hsa:6612; P55854; Q53HI9; Q6FGD4; Q9BWR4" "Exercise-induced circadian regulation" "SUMOylation of DNA damage response and repair proteins; Formation of Incision Complex in GG-NER; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; SUMOylation of transcription factors; SUMOylation of immune response proteins; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "12" "1" "0.820" "0.954" "0.776" "0.881" "0.813" "0.884" "0.855" "0.810" "0.728" "948.5" "778.2" "905.3" "736.5" "835.2" "771.1" "838.4" "810.9" "768.4" "690.1" "" "" "" "" "" "" "" "" "" "" "567.6" "404.4" "501.4" "345.8" "387.1" "394.8" "389.8" "364.1" "416.9" "690.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6751278663907923034" "False" "High" "IsMasterProtein" "Q9UFG5" "UPF0449 protein C19orf25 OS=Homo sapiens OX=9606 GN=C19orf25 PE=1 SV=2" "0.000" "False" "15.882" "40" "4" "6" "4" "118" "12.9" "5.07" "18.28" "4" "" "" "" "Pf15136" "148223" "ENSG00000119559" "C19orf25" "B3KQN6; hsa:148223; Q8N9R7; Q8WV94; Q9UFG5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3524975929259860741" "False" "High" "IsMasterProtein" "Q86X27" "Ras-specific guanine nucleotide-releasing factor RalGPS2 OS=Homo sapiens OX=9606 GN=RALGPS2 PE=1 SV=1" "0.000" "False" "15.868" "7" "4" "5" "4" "583" "65.1" "8.73" "14.63" "4" "signal transduction" "plasma membrane;other membranes;other cell component" "enzyme regulator activity" "Pf00169, Pf00617" "55103" "ENSG00000116191" "RALGPS2" "B7Z7B1; hsa:55103; Q5T5Z1; Q5VZ67; Q86X27; Q9NW78" "" "" "0" "0" "0.738" "1.104" "1.075" "1.027" "1.005" "0.974" "1.013" "1.160" "2.719" "110.3" "81.4" "121.9" "118.6" "113.3" "110.9" "107.5" "111.8" "127.9" "300.0" "" "" "" "" "" "" "" "" "" "" "66.0" "42.3" "67.5" "55.7" "52.5" "56.8" "50.0" "50.2" "69.4" "300.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8429981221702182893" "False" "High" "IsMasterProtein" "P20340" "Ras-related protein Rab-6A OS=Homo sapiens OX=9606 GN=RAB6A PE=1 SV=3" "0.000" "False" "15.818" "16" "3" "13" "2" "208" "23.6" "5.54" "32.91" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "5870" "ENSG00000175582" "RAB6A" "A8K133; B7Z772; F5H668; hsa:5870; P20340; Q1W5D8; Q5U0A8; Q9UBE4" "" "COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Pre-NOTCH Processing in Golgi; Retrograde transport at the Trans-Golgi-Network; TBC/RABGAPs" "7" "0" "0.916" "0.846" "0.812" "1.006" "1.070" "1.055" "0.895" "1.153" "1.202" "250.5" "229.4" "211.9" "203.4" "252.0" "268.0" "264.2" "224.2" "288.7" "301.2" "" "" "" "" "" "" "" "" "" "" "149.9" "119.2" "117.3" "95.5" "116.8" "137.2" "122.9" "100.7" "156.6" "301.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4473457085686512926" "False" "High" "IsMasterProtein" "Q16186" "Proteasomal ubiquitin receptor ADRM1 OS=Homo sapiens OX=9606 GN=ADRM1 PE=1 SV=2" "0.000" "False" "15.790" "8" "3" "4" "3" "407" "42.1" "5.07" "12.64" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04683, Pf16550" "11047" "ENSG00000130706" "ADRM1" "A0PKB1; hsa:11047; Q16186; Q96FJ7; Q9H1P2" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "Ub-specific processing proteases; UCH proteinases" "4" "0" "1.133" "1.050" "1.149" "1.148" "1.207" "1.043" "1.158" "1.228" "3.289" "181.8" "206.0" "191.0" "208.9" "208.8" "219.5" "189.6" "210.6" "223.3" "598.0" "" "" "" "" "" "" "" "" "" "" "108.8" "107.0" "105.8" "98.1" "96.8" "112.4" "88.2" "94.6" "121.2" "598.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6735907081845110604" "False" "High" "IsMasterProtein" "Q9Y2L1" "Exosome complex exonuclease RRP44 OS=Homo sapiens OX=9606 GN=DIS3 PE=1 SV=2" "0.000" "False" "15.781" "6" "5" "7" "5" "958" "108.9" "7.14" "11.06" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00773, Pf13638, Pf17215, Pf17216, Pf17849" "22894" "ENSG00000083520" "DIS3" "A6NI21; B2RBL2; hsa:22894; Q5W0P7; Q5W0P8; Q658Z7; Q7Z481; Q8WWI2; Q9UG36; Q9Y2L1" "" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "1.042" "1.027" "0.932" "1.081" "1.070" "1.096" "0.912" "1.122" "2.877" "303.6" "316.4" "312.0" "283.0" "328.3" "324.8" "332.8" "276.9" "340.6" "873.4" "" "" "" "" "" "" "" "" "" "" "181.7" "164.4" "172.8" "132.8" "152.2" "166.3" "154.7" "124.3" "184.8" "873.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4528933939237155494" "False" "High" "IsMasterProtein" "P25490" "Transcriptional repressor protein YY1 OS=Homo sapiens OX=9606 GN=YY1 PE=1 SV=2" "0.000" "False" "15.779" "11" "4" "4" "4" "414" "44.7" "6.25" "11.13" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "7528" "ENSG00000100811" "YY1" "hsa:7528; P25490; Q14935" "Sterol regulatory element-binding proteins (SREBP) signaling; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Pleural mesothelioma" "UCH proteinases; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; DNA Damage Recognition in GG-NER; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors" "8" "0" "1.088" "1.285" "1.216" "1.197" "1.412" "1.283" "1.006" "1.160" "2.397" "157.4" "171.3" "202.3" "191.4" "188.5" "222.2" "202.0" "158.3" "182.6" "377.2" "" "" "" "" "" "" "" "" "" "" "94.2" "89.0" "112.0" "89.9" "87.4" "113.8" "93.9" "71.1" "99.1" "377.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8574312361860662093" "False" "High" "IsMasterProtein" "Q92620" "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 OS=Homo sapiens OX=9606 GN=DHX38 PE=1 SV=2" "0.000" "False" "15.777" "3" "3" "4" "3" "1227" "140.4" "6.54" "11.21" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "9785" "ENSG00000140829" "DHX38" "B4DVG8; D3DWS7; hsa:9785; O75212; Q92620; Q96HN7" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "5" "0" "1.002" "0.906" "0.991" "1.159" "1.070" "1.052" "1.110" "1.025" "1.803" "136.9" "137.2" "124.0" "135.7" "158.7" "146.5" "144.1" "152.0" "140.3" "246.9" "" "" "" "" "" "" "" "" "" "" "81.9" "71.3" "68.7" "63.7" "73.6" "75.0" "67.0" "68.2" "76.1" "246.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7534759113121094513" "False" "High" "IsMasterProtein" "Q9Y3D9" "Small ribosomal subunit protein mS23 OS=Homo sapiens OX=9606 GN=MRPS23 PE=1 SV=2" "0.000" "False" "15.776" "23" "4" "5" "4" "190" "21.8" "8.90" "17.06" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf10484" "51649" "ENSG00000181610" "MRPS23" "B2R6V3; hsa:51649; Q96Q24; Q9BWH8; Q9P053; Q9Y3D9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.826" "0.838" "0.925" "1.028" "1.025" "1.004" "0.943" "0.908" "0.847" "185.8" "153.5" "155.6" "171.9" "191.0" "190.5" "186.5" "175.3" "168.8" "157.4" "" "" "" "" "" "" "" "" "" "" "111.2" "79.8" "86.2" "80.7" "88.5" "97.5" "86.7" "78.7" "91.6" "157.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6755202633810832906" "False" "High" "IsMasterProtein" "Q9C0I1" "Myotubularin-related protein 12 OS=Homo sapiens OX=9606 GN=MTMR12 PE=1 SV=2" "0.000" "False" "15.767" "8" "5" "6" "5" "747" "86.1" "6.62" "13.84" "5" "" "cytosol;cytoskeleton;ER/Golgi;other cell component" "" "Pf06602, Pf12578" "54545" "ENSG00000150712" "MTMR12" "hsa:54545; Q69YJ4; Q6PFW3; Q96QU2; Q9C0I1; Q9NX27" "" "Synthesis of PIPs at the early endosome membrane" "1" "0" "0.897" "0.876" "0.810" "1.017" "1.010" "0.944" "1.112" "0.912" "0.506" "181.5" "162.7" "159.0" "146.9" "184.5" "183.3" "171.2" "201.9" "165.6" "91.8" "" "" "" "" "" "" "" "" "" "" "108.6" "84.5" "88.1" "69.0" "85.5" "93.9" "79.6" "90.6" "89.8" "91.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8321429417116917544" "False" "High" "IsMasterProtein" "P07339" "Cathepsin D OS=Homo sapiens OX=9606 GN=CTSD PE=1 SV=1" "0.000" "False" "15.758" "12" "4" "8" "4" "412" "44.5" "6.54" "15.98" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00026, Pf07966" "1509" "ENSG00000117984" "CTSD" "hsa:1509; P07339; Q6IB57" "Prolactin signaling pathway; 8p23.1 copy number variation syndrome" "MHC class II antigen presentation; Neutrophil degranulation; Collagen degradation; Estrogen-dependent gene expression; Insulin receptor recycling; Metabolism of Angiotensinogen to Angiotensins" "8" "0" "1.058" "0.942" "0.994" "0.887" "0.972" "0.972" "1.024" "1.013" "0.527" "341.7" "361.4" "321.8" "339.5" "303.0" "332.2" "332.1" "350.0" "346.2" "180.0" "" "" "" "" "" "" "" "" "" "" "204.5" "187.8" "178.2" "159.4" "140.4" "170.1" "154.4" "157.1" "187.8" "180.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8454971752249747449" "False" "High" "IsMasterProtein" "Q9BSD7" "Cancer-related nucleoside-triphosphatase OS=Homo sapiens OX=9606 GN=NTPCR PE=1 SV=1" "0.000" "False" "15.710" "14" "2" "6" "2" "190" "20.7" "9.54" "18.65" "2" "" "" "other molecular function" "Pf03266" "84284" "ENSG00000135778" "NTPCR" "hsa:84284; Q9BSD7" "" "" "0" "0" "0.876" "0.934" "1.088" "1.202" "1.003" "0.939" "1.047" "0.992" "0.859" "127.7" "111.9" "119.3" "139.0" "153.6" "128.1" "119.9" "133.7" "126.7" "109.7" "" "" "" "" "" "" "" "" "" "" "76.4" "58.1" "66.1" "65.2" "71.2" "65.6" "55.7" "60.0" "68.8" "109.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2311027039317612116" "False" "High" "IsMasterProtein" "Q9Y3B8" "Oligoribonuclease, mitochondrial OS=Homo sapiens OX=9606 GN=REXO2 PE=1 SV=3" "0.000" "False" "15.706" "14" "3" "6" "3" "237" "26.8" "6.87" "19.18" "3" "DNA metabolism;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00929" "25996" "ENSG00000076043" "REXO2" "B2R532; hsa:25996; Q32Q18; Q53FT1; Q6FIC6; Q9UFY7; Q9Y3B8" "" "Mitochondrial RNA degradation" "1" "0" "1.053" "1.050" "1.056" "1.089" "0.891" "1.002" "1.037" "0.964" "0.447" "289.2" "304.7" "303.6" "305.4" "314.9" "257.7" "289.7" "300.0" "278.7" "129.4" "" "" "" "" "" "" "" "" "" "" "173.1" "158.3" "168.1" "143.4" "145.9" "131.9" "134.7" "134.7" "151.2" "129.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4990507016878311040" "False" "High" "IsMasterProtein" "P42126" "Enoyl-CoA delta isomerase 1, mitochondrial OS=Homo sapiens OX=9606 GN=ECI1 PE=1 SV=1" "0.000" "False" "15.703" "15" "4" "8" "4" "302" "32.8" "8.54" "22.52" "4" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00378" "1632" "ENSG00000167969" "ECI1" "A8K512; hsa:1632; P42126; Q13290; Q7Z2L6; Q7Z2L7; Q9BUB8; Q9BW05; Q9UDG6" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Mitochondrial fatty acid oxidation disorders" "Mitochondrial protein degradation; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" "5" "0" "1.053" "1.128" "1.144" "1.255" "1.071" "1.142" "1.203" "1.092" "0.667" "365.6" "385.1" "412.4" "418.4" "458.8" "391.5" "417.4" "439.9" "399.3" "243.9" "" "" "" "" "" "" "" "" "" "" "218.8" "200.1" "228.4" "196.4" "212.7" "200.4" "194.1" "197.5" "216.6" "243.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9168897576622990740" "False" "High" "IsMasterProtein" "O43617" "Trafficking protein particle complex subunit 3 OS=Homo sapiens OX=9606 GN=TRAPPC3 PE=1 SV=1" "0.000" "False" "15.697" "25" "6" "8" "6" "180" "20.3" "4.96" "19.70" "6" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "27095" "ENSG00000054116" "TRAPPC3" "A6NDN0; B2RDN2; D3DPS2; hsa:27095; O43617" "" "COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs" "2" "0" "1.156" "1.031" "1.064" "1.219" "1.120" "1.036" "1.128" "1.024" "0.982" "314.1" "363.2" "323.9" "334.2" "382.9" "351.8" "325.5" "354.3" "321.7" "308.4" "" "" "" "" "" "" "" "" "" "" "187.9" "188.7" "179.3" "156.9" "177.5" "180.1" "151.3" "159.0" "174.6" "308.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7202922108567294127" "False" "High" "IsMasterProtein" "Q8IZP0" "Abl interactor 1 OS=Homo sapiens OX=9606 GN=ABI1 PE=1 SV=4" "0.000" "False" "15.681" "10" "5" "10" "5" "508" "55.0" "7.06" "12.28" "5" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00018, Pf07815" "10006" "ENSG00000136754" "ABI1" "A9Z1Y6; B3KX62; B4DQ58; H7BXI6; hsa:10006; O15147; O76049; O95060; Q5T2R3; Q5T2R4; Q5T2R6; Q5T2R7; Q5T2R9; Q5W070; Q5W072; Q8IZP0; Q8TB63; Q96S81; Q9NXZ9; Q9NYB8" "EGF/EGFR signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "8" "0" "1.111" "1.215" "1.013" "1.018" "1.185" "1.109" "1.174" "1.116" "1.743" "144.6" "160.6" "175.7" "146.5" "147.3" "171.3" "160.3" "169.7" "161.3" "252.0" "" "" "" "" "" "" "" "" "" "" "86.5" "83.5" "97.3" "68.8" "68.3" "87.7" "74.5" "76.2" "87.5" "252.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5842118922115640430" "False" "High" "IsMasterProtein" "P36405" "ADP-ribosylation factor-like protein 3 OS=Homo sapiens OX=9606 GN=ARL3 PE=1 SV=2" "0.000" "False" "15.678" "32" "5" "10" "5" "182" "20.4" "7.24" "18.86" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00025" "403" "ENSG00000138175" "ARL3" "B2R6C7; hsa:403; P36405; Q53X83; Q5JSM2" "Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "Trafficking of myristoylated proteins to the cilium" "5" "0" "1.084" "1.040" "1.092" "1.000" "1.004" "1.098" "1.052" "1.073" "0.617" "287.4" "311.5" "298.8" "313.9" "287.5" "288.4" "315.6" "302.3" "308.3" "177.2" "" "" "" "" "" "" "" "" "" "" "172.0" "161.9" "165.5" "147.4" "133.3" "147.7" "146.8" "135.7" "167.3" "177.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6036677964263745223" "False" "High" "IsMasterProtein" "Q8NFH4" "Nucleoporin Nup37 OS=Homo sapiens OX=9606 GN=NUP37 PE=1 SV=1" "0.000" "False" "15.671" "12" "4" "7" "4" "326" "36.7" "5.92" "20.98" "4" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "79023" "ENSG00000075188" "NUP37" "hsa:79023; Q8NFH4; Q9H644" "" "Separation of Sister Chromatids; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; tRNA processing in the nucleus; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "35" "0" "0.931" "1.042" "0.945" "0.916" "0.994" "0.917" "1.019" "0.911" "0.655" "604.0" "562.1" "629.1" "570.8" "553.3" "600.2" "553.9" "615.6" "550.0" "395.6" "" "" "" "" "" "" "" "" "" "" "361.5" "292.1" "348.4" "268.0" "256.5" "307.3" "257.6" "276.4" "298.4" "395.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4607274144029287900" "False" "High" "IsMasterProtein" "O14929" "Histone acetyltransferase type B catalytic subunit OS=Homo sapiens OX=9606 GN=HAT1 PE=1 SV=2" "0.000" "False" "15.644" "14" "4" "4" "4" "419" "49.5" "5.69" "11.03" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf10394, Pf21183" "8520" "ENSG00000128708" "HAT1" "hsa:8520; O14929; Q49A44; Q53QF0; Q53SU4; Q6P594; Q8WWB9" "Ethanol effects on histone modifications" "HATs acetylate histones" "2" "0" "0.993" "0.924" "0.905" "0.983" "1.000" "1.005" "0.849" "1.043" "3.428" "131.0" "130.1" "121.1" "118.6" "128.7" "130.9" "131.6" "111.2" "136.6" "449.1" "" "" "" "" "" "" "" "" "" "" "78.4" "67.6" "67.0" "55.7" "59.7" "67.0" "61.2" "49.9" "74.1" "449.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6465314109903613014" "False" "High" "IsMasterProtein" "Q99615" "DnaJ homolog subfamily C member 7 OS=Homo sapiens OX=9606 GN=DNAJC7 PE=1 SV=2" "0.000" "False" "15.640" "10" "5" "6" "5" "494" "56.4" "6.96" "14.84" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00226" "7266" "ENSG00000168259" "DNAJC7" "hsa:7266; Q7Z784; Q99615" "Constitutive androstane receptor pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway" "Regulation of HSF1-mediated heat shock response" "4" "0" "0.973" "0.993" "1.098" "1.147" "1.081" "1.089" "0.344" "1.106" "6.144" "205.1" "199.6" "203.6" "225.1" "235.3" "221.7" "223.2" "70.5" "226.8" "1259.8" "" "" "" "" "" "" "" "" "" "" "122.7" "103.7" "112.7" "105.7" "109.0" "113.5" "103.8" "31.7" "123.0" "1259.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1337195466672693139" "False" "High" "IsMasterProtein" "Q9BZX2" "Uridine-cytidine kinase 2 OS=Homo sapiens OX=9606 GN=UCK2 PE=1 SV=1" "0.000" "False" "15.639" "16" "4" "8" "3" "261" "29.3" "6.70" "19.16" "4" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00485" "7371" "ENSG00000143179" "UCK2" "hsa:7371; Q5VV91; Q7KZV3; Q92528; Q96KG5; Q9BU42; Q9BZX2" "Fluoropyrimidine activity; Pyrimidine metabolism" "Pyrimidine salvage" "3" "1" "0.900" "0.823" "0.923" "0.964" "0.939" "0.977" "1.008" "0.930" "0.895" "701.2" "630.9" "576.8" "647.4" "676.0" "658.5" "684.9" "707.0" "652.0" "627.2" "" "" "" "" "" "" "" "" "" "" "419.6" "327.9" "319.4" "303.9" "313.4" "337.1" "318.5" "317.4" "353.7" "627.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "397277040626667291" "False" "High" "IsMasterProtein" "Q9UBB4" "Ataxin-10 OS=Homo sapiens OX=9606 GN=ATXN10 PE=1 SV=1" "0.000" "False" "15.638" "7" "3" "6" "3" "475" "53.5" "5.25" "19.39" "3" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf09759" "25814" "ENSG00000130638" "ATXN10" "A6NLC4; B4DG05; hsa:25814; O14998; O15009; Q6I9X4; Q9UBB4" "Ciliopathies" "" "1" "0" "1.072" "1.073" "1.038" "1.108" "1.163" "1.272" "0.993" "1.079" "2.035" "131.6" "141.1" "141.3" "136.6" "145.9" "153.1" "167.5" "130.8" "142.0" "267.9" "" "" "" "" "" "" "" "" "" "" "78.8" "73.3" "78.2" "64.1" "67.6" "78.4" "77.9" "58.7" "77.0" "267.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8905060599663970094" "False" "High" "IsMasterProtein" "Q9Y5K8" "V-type proton ATPase subunit D OS=Homo sapiens OX=9606 GN=ATP6V1D PE=1 SV=1" "0.000" "False" "15.638" "21" "5" "6" "5" "247" "28.2" "9.36" "18.03" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity" "Pf01813" "51382" "ENSG00000100554" "ATP6V1D" "B2RE33; hsa:51382; Q9Y5K8; Q9Y688" "Proximal tubule transport" "Neutrophil degranulation; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "7" "0" "1.029" "0.922" "0.939" "1.002" "1.084" "0.945" "0.948" "1.021" "0.868" "296.8" "305.3" "273.5" "278.7" "297.3" "321.6" "280.3" "281.4" "303.1" "257.7" "" "" "" "" "" "" "" "" "" "" "177.6" "158.7" "151.5" "130.9" "137.8" "164.7" "130.4" "126.3" "164.5" "257.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6734575471453550747" "False" "High" "IsMasterProtein" "Q6FI81" "Anamorsin OS=Homo sapiens OX=9606 GN=CIAPIN1 PE=1 SV=2" "0.000" "False" "15.574" "14" "4" "7" "4" "312" "33.6" "5.62" "17.61" "4" "cell organization and biogenesis;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf05093, Pf20922" "57019" "ENSG00000005194" "CIAPIN1" "A8K8B6; hsa:57019; O75206; O75207; Q6FI81; Q9H0W1; Q9P1L7" "" "Cytosolic iron-sulfur cluster assembly" "1" "0" "0.980" "1.043" "1.052" "1.153" "1.174" "0.972" "0.992" "1.013" "1.510" "413.4" "404.9" "431.1" "434.7" "476.8" "485.4" "401.8" "409.9" "418.6" "624.4" "" "" "" "" "" "" "" "" "" "" "247.4" "210.4" "238.7" "204.1" "221.0" "248.5" "186.8" "184.0" "227.1" "624.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4921032794514216116" "False" "High" "IsMasterProtein" "Q8WXX5" "DnaJ homolog subfamily C member 9 OS=Homo sapiens OX=9606 GN=DNAJC9 PE=1 SV=1" "0.000" "False" "15.549" "22" "5" "6" "5" "260" "29.9" "5.73" "12.78" "5" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00226" "23234" "ENSG00000213551" "DNAJC9" "B2RMW6; hsa:23234; Q8WXX5" "" "" "0" "0" "0.924" "0.853" "0.897" "1.162" "1.048" "1.115" "0.978" "1.200" "1.306" "150.0" "138.6" "127.9" "134.6" "174.3" "157.1" "167.3" "146.7" "180.0" "195.9" "" "" "" "" "" "" "" "" "" "" "89.8" "72.0" "70.8" "63.2" "80.8" "80.4" "77.8" "65.8" "97.6" "195.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5339836283997496681" "False" "High" "IsMasterProtein" "O95163" "Elongator complex protein 1 OS=Homo sapiens OX=9606 GN=ELP1 PE=1 SV=3" "0.000" "False" "15.525" "5" "5" "9" "5" "1332" "150.2" "5.94" "17.54" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04762" "8518" "ENSG00000070061" "ELP1" "hsa:8518; O95163; Q5JSV2; Q9H327; Q9UG87" "HDAC6 interactions in the central nervous system" "HATs acetylate histones" "2" "0" "0.812" "0.971" "1.033" "1.005" "1.002" "0.978" "0.937" "0.943" "1.189" "154.2" "125.2" "149.8" "159.3" "155.0" "154.6" "150.8" "144.6" "145.4" "183.4" "" "" "" "" "" "" "" "" "" "" "92.3" "65.0" "82.9" "74.8" "71.8" "79.1" "70.1" "64.9" "78.9" "183.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4533705047032389806" "False" "High" "IsMasterProtein" "P62241" "Small ribosomal subunit protein eS8 OS=Homo sapiens OX=9606 GN=RPS8 PE=1 SV=2" "0.000" "False" "15.510" "23" "4" "6" "4" "208" "24.2" "10.32" "13.42" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01201" "6202" "ENSG00000142937" "RPS8" "hsa:6202; P09058; P62241; Q6IRL7" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.903" "0.983" "0.706" "0.861" "1.106" "0.841" "0.757" "0.901" "1.864" "107.9" "97.4" "106.0" "76.1" "92.9" "119.3" "90.8" "81.7" "97.2" "201.1" "" "" "" "" "" "" "" "" "" "" "64.6" "50.6" "58.7" "35.7" "43.1" "61.0" "42.2" "36.7" "52.7" "201.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5264367170864335030" "False" "High" "IsMasterProtein" "Q96K76" "Ubiquitin carboxyl-terminal hydrolase 47 OS=Homo sapiens OX=9606 GN=USP47 PE=1 SV=3" "0.000" "False" "15.508" "5" "4" "4" "4" "1375" "157.2" "5.08" "8.82" "4" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf19718" "55031" "ENSG00000170242" "USP47" "B3KXF5; E9PM46; hsa:55031; Q658U0; Q86Y73; Q8TEP6; Q96K76; Q9BWI0; Q9NWN1" "" "Ub-specific processing proteases" "1" "0" "0.993" "1.282" "1.127" "1.024" "1.101" "1.364" "0.870" "0.927" "2.906" "38.7" "38.4" "49.6" "43.6" "39.7" "42.6" "52.8" "33.7" "35.9" "112.5" "" "" "" "" "" "" "" "" "" "" "23.2" "20.0" "27.5" "20.5" "18.4" "21.8" "24.5" "15.1" "19.5" "112.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "980650416735823729" "False" "High" "IsMasterProtein" "Q9UHD1" "Cysteine and histidine-rich domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHORDC1 PE=1 SV=2" "0.000" "False" "15.463" "14" "6" "6" "6" "332" "37.5" "7.87" "16.63" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf04968, Pf04969" "26973" "ENSG00000110172; ENSG00000285023" "CHORDC1" "B2R6P8; hsa:26973; Q6IN49; Q8WVL9; Q9H3D6; Q9UHD1" "" "" "0" "0" "1.190" "1.306" "1.131" "1.222" "1.281" "1.095" "1.074" "1.093" "2.120" "378.1" "449.8" "493.6" "427.5" "462.2" "484.1" "413.8" "405.9" "413.2" "801.4" "" "" "" "" "" "" "" "" "" "" "226.3" "233.8" "273.3" "200.7" "214.2" "247.8" "192.4" "182.2" "224.2" "801.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3643109724268830478" "False" "High" "IsMasterProtein" "Q8WUH1" "Protein Churchill OS=Homo sapiens OX=9606 GN=CHURC1 PE=1 SV=3" "0.000" "False" "15.440" "25" "2" "3" "2" "112" "12.9" "4.84" "10.36" "2" "signal transduction;other biological processes" "" "other molecular function" "Pf06573" "91612" "ENSG00000258289" "CHURC1" "A0A0C4DGJ7; B3KQ81; G3V1X3; G3V214; hsa:91612; Q8WUH1; Q9H3K7" "" "" "0" "0" "1.032" "0.928" "0.916" "0.798" "0.778" "0.780" "1.113" "0.822" "0.670" "92.6" "95.6" "85.9" "84.9" "74.0" "72.0" "72.3" "103.1" "76.2" "62.0" "" "" "" "" "" "" "" "" "" "" "55.4" "49.7" "47.6" "39.8" "34.3" "36.9" "33.6" "46.3" "41.3" "62.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2612054938348296953" "False" "High" "IsMasterProtein" "Q16595" "Frataxin, mitochondrial OS=Homo sapiens OX=9606 GN=FXN PE=1 SV=2" "0.000" "False" "15.395" "19" "3" "5" "3" "210" "23.1" "8.69" "15.24" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf01491" "2395" "ENSG00000165060" "FXN" "A8MXJ6; C9JJ89; hsa:2395; O15545; O95656; Q15294; Q16595; Q5VZ01" "Iron-sulfur cluster biogenesis" "Mitochondrial protein import; Mitochondrial iron-sulfur cluster biogenesis" "3" "0" "0.854" "0.787" "0.980" "0.907" "0.756" "0.707" "0.675" "0.876" "0.716" "86.5" "73.9" "68.1" "84.8" "78.4" "65.4" "61.1" "58.4" "75.8" "61.9" "" "" "" "" "" "" "" "" "" "" "51.8" "38.4" "37.7" "39.8" "36.4" "33.5" "28.4" "26.2" "41.1" "61.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4830366311257218609" "False" "High" "IsMasterProtein" "P48147" "Prolyl endopeptidase OS=Homo sapiens OX=9606 GN=PREP PE=1 SV=2" "0.000" "False" "15.391" "7" "5" "5" "5" "710" "80.6" "5.86" "13.42" "5" "protein metabolism" "cytosol;nucleus;other cell component" "other molecular function" "Pf00326, Pf02897" "5550" "ENSG00000085377" "PREP" "hsa:5550; P48147; Q8N6D4" "" "" "0" "0" "1.058" "1.268" "0.937" "1.032" "1.173" "1.324" "0.294" "1.161" "8.066" "89.3" "94.4" "113.2" "83.6" "92.1" "104.7" "118.1" "26.2" "103.6" "720.0" "" "" "" "" "" "" "" "" "" "" "53.4" "49.1" "62.7" "39.3" "42.7" "53.6" "54.9" "11.8" "56.2" "720.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8778470671322458913" "False" "High" "IsMasterProtein" "Q71UI9" "Histone H2A.V OS=Homo sapiens OX=9606 GN=H2AZ2 PE=1 SV=3" "0.000" "False" "15.385" "20" "3" "11" "1" "128" "13.5" "10.58" "29.92" "3" "cell organization and biogenesis" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "94239" "ENSG00000105968" "H2AZ2" "A6NFA8; A6NKY0; A6NN01; A8MQC5; hsa:94239; Q59GV8; Q6PK98; Q71UI9" "FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "Transcriptional regulation by small RNAs; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of the beta-catenin:TCF transactivating complex; RMTs methylate histone arginines; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Meiotic synapsis; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Chromatin modifications during the maternal to zygotic transition (MZT); Meiotic recombination; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis" "35" "0" "0.797" "0.835" "0.630" "0.947" "0.801" "1.019" "0.706" "0.820" "2.710" "78.6" "62.7" "65.6" "49.5" "74.4" "63.0" "80.1" "55.5" "64.4" "212.9" "" "" "" "" "" "" "" "" "" "" "47.0" "32.6" "36.3" "23.3" "34.5" "32.2" "37.2" "24.9" "35.0" "212.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8218333417811039911" "False" "High" "IsMasterProtein" "Q9H299" "SH3 domain-binding glutamic acid-rich-like protein 3 OS=Homo sapiens OX=9606 GN=SH3BGRL3 PE=1 SV=1" "0.000" "False" "15.383" "43" "4" "23" "4" "93" "10.4" "4.93" "66.06" "4" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf04908" "83442" "ENSG00000142669" "SH3BGRL3" "hsa:83442; Q5T122; Q9H299" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.997" "0.993" "0.935" "0.960" "0.986" "0.959" "1.030" "0.923" "0.473" "2535.8" "2528.3" "2518.3" "2370.7" "2433.5" "2500.6" "2431.5" "2611.4" "2340.5" "1199.8" "" "" "" "" "" "" "" "" "" "" "1517.5" "1313.8" "1394.6" "1113.0" "1128.0" "1280.1" "1130.6" "1172.4" "1269.8" "1199.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8561643854279228847" "False" "High" "IsMasterProtein" "P15927" "Replication protein A 32 kDa subunit OS=Homo sapiens OX=9606 GN=RPA2 PE=1 SV=1" "0.000" "False" "15.378" "19" "4" "10" "4" "270" "29.2" "6.15" "22.12" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08784" "6118" "ENSG00000117748" "RPA2" "hsa:6118; P15927; Q52II0; Q5TEI9; Q5TEJ5" "miRNA regulation of DNA damage response; Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair; DNA damage response" "Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Homologous Recombination (HRR); Meiotic recombination; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Activation of the pre-replicative complex; Termination of translesion DNA synthesis; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "38" "0" "1.035" "1.029" "1.036" "1.138" "1.245" "1.210" "1.243" "1.240" "1.139" "583.4" "604.0" "600.1" "604.3" "663.9" "726.1" "705.7" "725.1" "723.1" "664.3" "" "" "" "" "" "" "" "" "" "" "349.1" "313.9" "332.3" "283.7" "307.7" "371.7" "328.1" "325.5" "392.3" "664.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4287058177622287432" "False" "High" "IsMasterProtein" "O95757" "Heat shock 70 kDa protein 4L OS=Homo sapiens OX=9606 GN=HSPA4L PE=1 SV=3" "0.000" "False" "15.358" "6" "4" "4" "3" "839" "94.5" "5.88" "10.02" "4" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00012" "22824" "ENSG00000164070" "HSPA4L" "A2ICT2; hsa:22824; O95757; Q4W5M5; Q8IWA2" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "1.674" "1.389" "1.632" "1.752" "1.629" "1.558" "1.616" "1.377" "5.581" "20.8" "34.8" "28.9" "33.9" "36.4" "33.8" "32.4" "33.6" "28.6" "115.9" "" "" "" "" "" "" "" "" "" "" "12.4" "18.1" "16.0" "15.9" "16.9" "17.3" "15.0" "15.1" "15.5" "115.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7747633478491734615" "False" "High" "IsMasterProtein" "Q96BW5" "Phosphotriesterase-related protein OS=Homo sapiens OX=9606 GN=PTER PE=1 SV=1" "0.000" "False" "15.341" "13" "5" "5" "5" "349" "39.0" "6.52" "15.67" "5" "other metabolic processes;other biological processes" "" "other molecular function" "Pf02126" "9317" "ENSG00000165983" "PTER" "B0YJ77; B3KTF5; D3DRU0; hsa:9317; Q96BW5; Q9BY46" "" "" "0" "0" "1.063" "1.067" "1.040" "1.169" "1.023" "1.047" "1.070" "1.136" "0.607" "327.4" "348.0" "349.4" "340.3" "382.6" "335.0" "342.6" "350.2" "372.0" "198.6" "" "" "" "" "" "" "" "" "" "" "195.9" "180.9" "193.5" "159.8" "177.3" "171.5" "159.3" "157.2" "201.8" "198.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4178938987355296714" "False" "High" "IsMasterProtein" "P62312" "U6 snRNA-associated Sm-like protein LSm6 OS=Homo sapiens OX=9606 GN=LSM6 PE=1 SV=1" "0.000" "False" "15.334" "46" "4" "16" "4" "80" "9.1" "9.58" "37.59" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01423" "11157" "ENSG00000164167" "LSM6" "hsa:11157; P62312; Q4W5J5; Q9Y4Y8" "" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "2" "0" "1.185" "1.138" "1.022" "1.127" "1.247" "1.055" "1.000" "1.174" "1.249" "449.2" "532.5" "511.0" "459.0" "506.3" "560.4" "473.9" "449.3" "527.3" "561.0" "" "" "" "" "" "" "" "" "" "" "268.8" "276.7" "283.0" "215.5" "234.7" "286.9" "220.4" "201.7" "286.1" "561.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3037731205086659877" "False" "High" "IsMasterProtein" "P09234" "U1 small nuclear ribonucleoprotein C OS=Homo sapiens OX=9606 GN=SNRPC PE=1 SV=1" "0.000" "False" "15.317" "25" "3" "9" "3" "159" "17.4" "9.67" "30.40" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06220" "6631" "ENSG00000124562" "SNRPC" "hsa:6631; P09234; Q5TAL3" "" "mRNA Splicing - Major Pathway" "1" "0" "0.914" "0.935" "0.892" "0.843" "0.929" "0.990" "0.995" "0.898" "0.246" "884.4" "808.0" "827.1" "788.7" "745.9" "821.6" "875.4" "880.0" "793.9" "217.7" "" "" "" "" "" "" "" "" "" "" "529.3" "419.9" "458.0" "370.3" "345.7" "420.6" "407.0" "395.0" "430.7" "217.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7497019614434814723" "False" "High" "IsMasterProtein" "Q9NQH7" "Xaa-Pro aminopeptidase 3 OS=Homo sapiens OX=9606 GN=XPNPEP3 PE=1 SV=1" "0.000" "False" "15.314" "9" "4" "23" "3" "507" "57.0" "6.83" "57.61" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00557, Pf05195" "63929" "ENSG00000196236" "XPNPEP3" "B2R9G1; B7Z790; B7Z7B2; hsa:63929; Q6I9V9; Q8NDA6; Q9BV27; Q9BVH0; Q9NQH7" "Ciliary landscape; Ciliopathies" "" "2" "0" "1.257" "0.942" "1.350" "1.027" "1.329" "1.641" "1.430" "1.092" "0.922" "27.9" "35.1" "26.3" "37.7" "28.7" "37.1" "45.8" "39.9" "30.5" "25.7" "" "" "" "" "" "" "" "" "" "" "16.7" "18.2" "14.6" "17.7" "13.3" "19.0" "21.3" "17.9" "16.6" "25.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8717421015690566095" "False" "High" "IsMasterProtein" "Q9NQR4" "Omega-amidase NIT2 OS=Homo sapiens OX=9606 GN=NIT2 PE=1 SV=1" "0.000" "False" "15.313" "21" "6" "8" "6" "276" "30.6" "7.21" "19.68" "6" "other metabolic processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00795" "56954" "ENSG00000114021" "NIT2" "B2R9A3; D3DN47; hsa:56954; Q8WUF0; Q9NQR4" "" "Neutrophil degranulation" "1" "0" "1.013" "1.002" "1.032" "0.968" "1.008" "0.973" "1.067" "1.007" "0.710" "713.6" "722.9" "714.9" "736.4" "690.9" "719.3" "694.3" "761.4" "718.2" "506.8" "" "" "" "" "" "" "" "" "" "" "427.0" "375.7" "395.9" "345.7" "320.2" "368.2" "322.8" "341.8" "389.7" "506.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7303961078788059209" "False" "High" "IsMasterProtein" "P49792" "E3 SUMO-protein ligase RanBP2 OS=Homo sapiens OX=9606 GN=RANBP2 PE=1 SV=2" "0.000" "False" "15.270" "1" "5" "6" "4" "3224" "358.0" "6.20" "16.59" "5" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00160, Pf00638, Pf00641, Pf12185" "5903" "ENSG00000153201" "RANBP2" "hsa:5903; P49792; Q13074; Q15280; Q53TE2; Q59FH7" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; Viral Messenger RNA Synthesis; SUMOylation of DNA damage response and repair proteins; Rev-mediated nuclear export of HIV RNA; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signaling by ALK fusions and activated point mutants" "35" "1" "1.208" "1.186" "1.286" "1.299" "1.208" "1.350" "0.756" "1.227" "6.679" "151.7" "183.2" "180.0" "195.1" "197.0" "183.2" "204.7" "114.7" "186.1" "1013.1" "" "" "" "" "" "" "" "" "" "" "90.8" "95.2" "99.7" "91.6" "91.3" "93.8" "95.2" "51.5" "101.0" "1013.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8127348192762311520" "False" "High" "IsMasterProtein" "Q96HN2" "Adenosylhomocysteinase 3 OS=Homo sapiens OX=9606 GN=AHCYL2 PE=1 SV=1" "0.000" "False" "15.250" "4" "4" "10" "1" "611" "66.7" "7.36" "24.92" "4" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00670, Pf05221" "23382" "ENSG00000158467" "AHCYL2" "B4DIZ5; D9N155; hsa:23382; O94917; Q96HN2" "One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Spina bifida" "Bicarbonate transporters" "4" "0" "1.006" "0.941" "1.022" "1.094" "0.907" "0.990" "1.296" "0.958" "0.607" "123.9" "124.7" "116.5" "126.6" "135.5" "112.4" "122.7" "160.6" "118.6" "75.2" "" "" "" "" "" "" "" "" "" "" "74.1" "64.8" "64.5" "59.4" "62.8" "57.5" "57.0" "72.1" "64.4" "75.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3787459776374465912" "False" "High" "IsMasterProtein" "Q9Y5L0" "Transportin-3 OS=Homo sapiens OX=9606 GN=TNPO3 PE=1 SV=3" "0.000" "False" "15.146" "4" "3" "3" "3" "923" "104.1" "5.57" "10.52" "3" "transport" "other membranes;nucleus;other cell component" "other molecular function" "Pf08389" "23534" "ENSG00000064419" "TNPO3" "A4D1K9; C9IZM0; hsa:23534; Q6NUM1; Q96G71; Q96GU9; Q9Y3R2; Q9Y5L0" "" "" "0" "0" "1.043" "1.104" "1.118" "1.339" "0.925" "0.974" "0.657" "1.031" "5.451" "46.0" "48.0" "50.8" "51.5" "61.6" "42.6" "44.8" "30.2" "47.5" "251.0" "" "" "" "" "" "" "" "" "" "" "27.6" "24.9" "28.1" "24.2" "28.6" "21.8" "20.8" "13.6" "25.8" "251.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8335320329939268762" "False" "High" "IsMasterProtein" "Q9UBR2" "Cathepsin Z OS=Homo sapiens OX=9606 GN=CTSZ PE=1 SV=1" "0.000" "False" "15.132" "13" "4" "11" "4" "303" "33.8" "7.11" "31.30" "4" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00112" "1522" "ENSG00000101160" "CTSZ" "B2RC40; hsa:1522; O75331; Q9UBR2; Q9UQV5; Q9UQV6" "" "Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins; Lysosome Vesicle Biogenesis; COPII-mediated vesicle transport; Cargo concentration in the ER" "5" "0" "0.896" "0.910" "0.875" "0.924" "1.044" "0.775" "0.929" "0.945" "0.573" "1142.1" "1023.8" "1039.3" "999.8" "1055.4" "1192.6" "885.2" "1061.2" "1079.7" "654.0" "" "" "" "" "" "" "" "" "" "" "683.5" "532.0" "575.6" "469.4" "489.2" "610.5" "411.6" "476.4" "585.8" "654.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9137773696009286865" "False" "High" "IsMasterProtein" "P58546" "Myotrophin OS=Homo sapiens OX=9606 GN=MTPN PE=1 SV=2" "0.000" "False" "15.127" "29" "3" "6" "3" "118" "12.9" "5.52" "15.34" "3" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf12796" "136319" "ENSG00000105887" "MTPN" "hsa:136319; P58546" "" "" "0" "0" "1.038" "1.074" "1.070" "1.200" "1.118" "1.157" "1.070" "1.073" "1.120" "399.1" "414.4" "428.6" "427.0" "478.9" "446.1" "461.7" "426.8" "428.2" "447.1" "" "" "" "" "" "" "" "" "" "" "238.8" "215.3" "237.3" "200.5" "222.0" "228.4" "214.7" "191.6" "232.3" "447.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8349989266333908893" "False" "High" "IsMasterProtein" "P49841" "Glycogen synthase kinase-3 beta OS=Homo sapiens OX=9606 GN=GSK3B PE=1 SV=2" "0.000" "False" "15.127" "13" "4" "6" "3" "420" "46.7" "8.78" "14.46" "4" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "2932" "ENSG00000082701" "GSK3B" "D3DN89; hsa:2932; P49841; Q9BWH3; Q9UL47" "IL-5 signaling pathway; Androgen receptor signaling pathway; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Cell cycle; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; IL-17 signaling pathway; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Focal adhesion; Copper homeostasis; Melatonin metabolism and effects; Wnt signaling pathway; IL6 signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Regulation of apoptosis by parathyroid hormone-related protein; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Wnt signaling pathway and pluripotency; PI3K/AKT/mTOR - vitamin D3 signaling; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; Acute viral myocarditis; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; NRF2-ARE regulation; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Gastrin signaling pathway; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Influence of laminopathies on Wnt signaling; MAP3K1 role in promoting and blocking gonadal determination; Overlap between signal transduction pathways contributing to LMNA laminopathies; Glycogen synthesis and degradation; Pleural mesothelioma; CCL18 signaling pathway; Alzheimer's disease; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Neurogenesis regulation in the olfactory epithelium; Sildenafil treatment; Macrophage-stimulating protein (MSP) signaling network map; HDAC6 interactions in the central nervous system; Notch signaling pathway; ErbB signaling pathway; DNA damage response (only ATM dependent)" "Regulation of HSF1-mediated heat shock response; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Ubiquitin-dependent degradation of Cyclin D; Regulation of RUNX2 expression and activity; Constitutive Signaling by AKT1 E17K in Cancer; B-WICH complex positively regulates rRNA expression; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; CRMPs in Sema3A signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; AKT phosphorylates targets in the cytosol; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Maturation of nucleoprotein; Maturation of nucleoprotein" "95" "1" "0.970" "0.994" "1.031" "1.030" "0.946" "0.928" "0.994" "1.042" "1.072" "213.5" "207.1" "212.1" "220.1" "219.8" "201.9" "198.1" "212.2" "222.4" "228.9" "" "" "" "" "" "" "" "" "" "" "127.7" "107.6" "117.5" "103.3" "101.9" "103.4" "92.1" "95.2" "120.7" "228.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3533689105478908948" "False" "High" "IsMasterProtein" "Q15369" "Elongin-C OS=Homo sapiens OX=9606 GN=ELOC PE=1 SV=1" "0.000" "False" "15.081" "58" "5" "5" "5" "112" "12.5" "4.78" "13.74" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03931" "6921" "ENSG00000154582" "ELOC" "E5RGD9; hsa:6921; Q15369; Q567Q6" "Dual hijack model of Vif in HIV infection; VEGFA-VEGFR2 signaling; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Antigen processing: Ubiquitination & Proteasome degradation; Regulation of expression of SLITs and ROBOs; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling; Evasion by RSV of host interferon responses" "22" "0" "1.034" "1.106" "1.086" "1.103" "1.211" "1.299" "1.209" "1.268" "1.288" "255.0" "263.6" "282.1" "276.9" "281.2" "308.9" "331.2" "308.4" "323.5" "328.6" "" "" "" "" "" "" "" "" "" "" "152.6" "137.0" "156.2" "130.0" "130.3" "158.1" "154.0" "138.4" "175.5" "328.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7438852567896609676" "False" "High" "IsMasterProtein" "Q7L5N1" "COP9 signalosome complex subunit 6 OS=Homo sapiens OX=9606 GN=COPS6 PE=1 SV=1" "0.000" "False" "15.078" "13" "4" "9" "4" "327" "36.1" "5.73" "27.56" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01398, Pf13012" "10980" "ENSG00000168090" "COPS6" "A4D2A3; hsa:10980; O15387; Q7L5N1" "Nucleotide-binding oligomerization domain (NOD) pathway; Ciliary landscape" "Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER; Cargo recognition for clathrin-mediated endocytosis" "6" "0" "1.104" "0.993" "1.005" "1.054" "1.129" "0.987" "1.136" "1.063" "0.750" "822.5" "908.0" "816.6" "826.9" "866.6" "928.6" "812.0" "934.1" "874.2" "616.9" "" "" "" "" "" "" "" "" "" "" "492.2" "471.8" "452.2" "388.2" "401.7" "475.4" "377.6" "419.4" "474.3" "616.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2201882454177381815" "False" "High" "IsMasterProtein" "P63241" "Eukaryotic translation initiation factor 5A-1 OS=Homo sapiens OX=9606 GN=EIF5A PE=1 SV=2" "0.000" "False" "15.073" "18" "4" "13" "4" "154" "16.8" "5.24" "29.45" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01287, Pf21485" "1984" "ENSG00000132507; ENSG00000288145" "EIF5A" "A8K9A0; D3DTP2; hsa:1984; P10159; P63241; Q16182; Q7L7L3; Q7Z4L1; Q9D0G2" "Translation factors; eIF5A regulation in response to inhibition of the nuclear export system" "Hypusine synthesis from eIF5A-lysine" "3" "0" "1.022" "1.202" "0.997" "1.151" "0.999" "1.026" "0.914" "1.067" "2.443" "794.7" "812.3" "955.6" "792.3" "915.0" "794.1" "815.4" "726.2" "847.8" "1941.5" "" "" "" "" "" "" "" "" "" "" "475.6" "422.1" "529.2" "372.0" "424.1" "406.5" "379.1" "326.0" "460.0" "1941.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5122002380756434681" "False" "High" "IsMasterProtein" "Q9Y6E2" "eIF5-mimic protein 1 OS=Homo sapiens OX=9606 GN=BZW2 PE=1 SV=1" "0.000" "False" "15.020" "11" "6" "18" "6" "419" "48.1" "6.68" "37.11" "6" "other biological processes" "other cell component" "" "Pf02020" "28969" "ENSG00000136261" "BZW2" "A4D123; hsa:28969; Q3B779; Q96JW5; Q9H3F7; Q9Y6E2" "" "" "0" "0" "1.000" "1.298" "1.128" "1.188" "1.024" "1.016" "0.767" "1.018" "4.097" "446.1" "446.2" "579.1" "503.1" "529.9" "456.6" "453.1" "342.1" "454.3" "1827.6" "" "" "" "" "" "" "" "" "" "" "267.0" "231.9" "320.7" "236.2" "245.6" "233.7" "210.7" "153.6" "246.5" "1827.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5241124612822470915" "False" "High" "IsMasterProtein" "P36639" "Oxidized purine nucleoside triphosphate hydrolase OS=Homo sapiens OX=9606 GN=NUDT1 PE=1 SV=4" "0.000" "False" "15.008" "17" "2" "4" "2" "156" "17.9" "5.08" "12.16" "2" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "4521" "ENSG00000106268" "NUDT1" "A4D205; hsa:4521; P36639; Q6LES7; Q6P0Y6; Q7Z7N6; Q8IV95; Q9UBM0; Q9UBM9" "" "" "0" "0" "1.201" "1.459" "1.295" "1.229" "0.961" "1.225" "0.910" "1.122" "3.691" "117.5" "141.1" "171.4" "152.2" "144.3" "112.9" "143.9" "106.9" "131.8" "433.5" "" "" "" "" "" "" "" "" "" "" "70.3" "73.3" "94.9" "71.4" "66.9" "57.8" "66.9" "48.0" "71.5" "433.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3740771680866674362" "False" "High" "IsMasterProtein" "P62993" "Growth factor receptor-bound protein 2 OS=Homo sapiens OX=9606 GN=GRB2 PE=1 SV=1" "0.000" "False" "15.008" "23" "5" "12" "5" "217" "25.2" "6.32" "22.46" "5" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018" "2885" "ENSG00000177885" "GRB2" "hsa:2885; P29354; P62993; Q14450; Q63057; Q63059" "IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; IL-9 signaling pathway; Pilocytic astrocytoma; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; p38 MAPK signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; Thermogenesis; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 distal deletion syndrome; Modulators of TCR signaling and T cell activation; Kallmann syndrome; Pleural mesothelioma; Congenital generalized lipodystrophy; GDNF signaling; 2q13 copy number variation syndrome; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "Signaling by ALK fusions and activated point mutants; Signaling by CSF3 (G-CSF); Signaling by FLT3 ITD and TKD mutants; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling" "73" "0" "1.060" "1.081" "1.099" "1.094" "1.026" "1.145" "1.100" "1.011" "1.063" "607.1" "643.4" "656.5" "667.0" "664.1" "622.7" "695.2" "668.0" "613.9" "645.4" "" "" "" "" "" "" "" "" "" "" "363.3" "334.4" "363.5" "313.1" "307.8" "318.8" "323.3" "299.9" "333.0" "645.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7462216625703255168" "False" "High" "IsMasterProtein" "O43847" "Nardilysin OS=Homo sapiens OX=9606 GN=NRDC PE=1 SV=3" "0.000" "False" "15.004" "3" "4" "5" "4" "1151" "131.6" "4.98" "10.28" "4" "protein metabolism;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00675, Pf05193, Pf16187" "4898" "ENSG00000078618" "NRDC" "A6NI41; hsa:4898; O15241; O15242; O43847; Q5VUL0; Q96HB2; Q9NU57" "" "" "0" "0" "1.164" "1.226" "1.344" "1.450" "1.058" "1.082" "0.943" "1.129" "3.178" "112.2" "130.6" "137.6" "150.9" "162.7" "118.7" "121.5" "105.8" "126.7" "356.6" "" "" "" "" "" "" "" "" "" "" "67.2" "67.9" "76.2" "70.8" "75.4" "60.8" "56.5" "47.5" "68.7" "356.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5230612763215460817" "False" "High" "IsMasterProtein" "Q99829" "Copine-1 OS=Homo sapiens OX=9606 GN=CPNE1 PE=1 SV=1" "0.000" "False" "14.998" "9" "6" "9" "6" "537" "59.0" "5.83" "16.93" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf07002" "8904" "ENSG00000214078" "CPNE1" "E1P5Q4; hsa:8904; Q6IBL3; Q99829; Q9H243; Q9NTZ7" "" "Neutrophil degranulation; Glycerophospholipid biosynthesis" "2" "0" "1.013" "1.088" "1.043" "1.056" "1.061" "1.074" "1.057" "1.081" "1.575" "392.3" "397.4" "426.8" "409.3" "414.4" "416.1" "421.2" "414.8" "424.0" "617.9" "" "" "" "" "" "" "" "" "" "" "234.8" "206.5" "236.3" "192.2" "192.1" "213.0" "195.8" "186.2" "230.1" "617.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "272489793728892869" "False" "High" "IsMasterProtein" "Q14696" "LRP chaperone MESD OS=Homo sapiens OX=9606 GN=MESD PE=1 SV=2" "0.000" "False" "14.986" "20" "5" "6" "5" "234" "26.1" "7.78" "18.68" "5" "cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf10185" "23184" "ENSG00000117899" "MESD" "B4DW84; D3DW96; hsa:23184; Q14696; Q969U1" "" "" "0" "0" "1.011" "0.974" "0.959" "1.143" "1.045" "1.088" "1.250" "1.003" "0.760" "576.9" "583.2" "561.9" "553.5" "659.1" "603.0" "627.5" "721.3" "578.7" "438.3" "" "" "" "" "" "" "" "" "" "" "345.2" "303.1" "311.2" "259.8" "305.5" "308.7" "291.8" "323.8" "314.0" "438.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3251475669442544967" "False" "High" "IsMasterProtein" "Q9P270" "SLAIN motif-containing protein 2 OS=Homo sapiens OX=9606 GN=SLAIN2 PE=1 SV=2" "0.000" "False" "14.946" "11" "4" "4" "4" "581" "62.5" "9.45" "9.36" "4" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf15301" "57606" "ENSG00000109171" "SLAIN2" "A8K4P1; hsa:57606; Q8N5R3; Q9P270" "" "" "0" "0" "1.081" "1.071" "0.909" "0.932" "0.868" "1.094" "1.002" "0.939" "0.708" "89.8" "97.0" "96.2" "81.7" "83.7" "78.0" "98.3" "90.0" "84.3" "63.6" "" "" "" "" "" "" "" "" "" "" "53.7" "50.4" "53.3" "38.3" "38.8" "39.9" "45.7" "40.4" "45.7" "63.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8408211072324921186" "False" "High" "IsMasterProtein" "P78344" "Eukaryotic translation initiation factor 4 gamma 2 OS=Homo sapiens OX=9606 GN=EIF4G2 PE=1 SV=1" "0.000" "False" "14.893" "5" "5" "10" "5" "907" "102.3" "7.14" "22.88" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf02020, Pf02847, Pf02854" "1982" "ENSG00000110321" "EIF4G2" "hsa:1982; O60877; P78344; P78404; Q0VH00; Q0VH01; Q2NKW9; Q49A79; Q53EU1; Q58EZ2; Q8NI71; Q96C16" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation; Acute viral myocarditis" "ISG15 antiviral mechanism" "4" "0" "1.060" "1.125" "1.115" "1.215" "1.022" "0.967" "0.625" "0.937" "5.415" "140.5" "148.9" "158.0" "156.7" "170.7" "143.7" "135.8" "87.9" "131.6" "761.0" "" "" "" "" "" "" "" "" "" "" "84.1" "77.4" "87.5" "73.6" "79.1" "73.6" "63.2" "39.4" "71.4" "761.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3187719389386559931" "False" "High" "IsMasterProtein" "Q9Y2V2" "Calcium-regulated heat-stable protein 1 OS=Homo sapiens OX=9606 GN=CARHSP1 PE=1 SV=2" "0.000" "False" "14.884" "36" "5" "10" "5" "147" "15.9" "8.21" "22.10" "5" "signal transduction;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00313" "23589" "ENSG00000153048" "CARHSP1" "B2R4C3; D3DUF5; hsa:23589; Q2YDX5; Q9BQ53; Q9Y2V2" "" "" "0" "0" "1.135" "1.121" "1.067" "1.149" "1.124" "1.248" "1.247" "1.113" "0.705" "418.2" "474.6" "468.8" "446.1" "480.6" "470.1" "522.0" "521.6" "465.3" "294.8" "" "" "" "" "" "" "" "" "" "" "250.3" "246.6" "259.6" "209.4" "222.7" "240.6" "242.7" "234.1" "252.5" "294.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1007819713485126010" "False" "High" "IsMasterProtein" "P83916" "Chromobox protein homolog 1 OS=Homo sapiens OX=9606 GN=CBX1 PE=1 SV=1" "0.000" "False" "14.843" "18" "3" "6" "2" "185" "21.4" "4.93" "15.47" "3" "cell organization and biogenesis;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00385, Pf01393" "10951" "ENSG00000108468" "CBX1" "hsa:10951; P23197; P83916" "Effect of progerin on genes involved in progeria" "HCMV Early Events" "2" "0" "1.072" "1.291" "0.980" "1.061" "1.133" "0.832" "0.899" "1.144" "0.521" "46.2" "49.5" "59.6" "45.3" "49.0" "52.3" "38.4" "41.5" "52.8" "24.1" "" "" "" "" "" "" "" "" "" "" "27.6" "25.7" "33.0" "21.2" "22.7" "26.8" "17.9" "18.6" "28.7" "24.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1767684544015944843" "False" "High" "IsMasterProtein" "P14678" "Small nuclear ribonucleoprotein-associated proteins B and B' OS=Homo sapiens OX=9606 GN=SNRPB PE=1 SV=2" "0.000" "False" "14.816" "21" "6" "14" "6" "240" "24.6" "11.19" "41.29" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "6628" "ENSG00000125835" "SNRPB" "hsa:6628; P14678; Q15490; Q6IB35; Q9UIS5" "mRNA processing" "snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "0.839" "0.839" "0.843" "0.894" "0.902" "0.889" "0.843" "0.842" "0.468" "871.3" "731.1" "731.1" "734.1" "779.0" "785.5" "774.8" "734.3" "733.6" "407.5" "" "" "" "" "" "" "" "" "" "" "521.4" "379.9" "404.8" "344.7" "361.1" "402.1" "360.3" "329.7" "398.0" "407.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2931302988534192752" "False" "High" "IsMasterProtein" "Q53QZ3" "Rho GTPase-activating protein 15 OS=Homo sapiens OX=9606 GN=ARHGAP15 PE=1 SV=2" "0.000" "False" "14.810" "7" "3" "4" "3" "475" "54.5" "9.39" "11.85" "3" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf00169, Pf00620" "55843" "ENSG00000075884" "ARHGAP15" "hsa:55843; Q53QZ3; Q53R36; Q53RD7; Q53RT6; Q53SX9; Q584N9; Q6PJE6; Q86WP1; Q8IXX1; Q9NRL8; Q9NZ77; Q9NZ91" "Ectoderm differentiation; Ectoderm differentiation" "RAC1 GTPase cycle; RAC3 GTPase cycle" "4" "0" "1.744" "1.247" "1.408" "1.490" "1.744" "1.599" "1.136" "1.663" "7.394" "52.6" "91.8" "65.6" "74.1" "78.4" "91.8" "84.2" "59.8" "87.5" "389.1" "" "" "" "" "" "" "" "" "" "" "31.5" "47.7" "36.4" "34.8" "36.3" "47.0" "39.1" "26.8" "47.5" "389.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-105519067553436175" "False" "High" "IsMasterProtein" "Q04323" "UBX domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBXN1 PE=1 SV=2" "0.000" "False" "14.786" "19" "4" "4" "4" "297" "33.3" "5.25" "12.67" "4" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00627, Pf00789" "51035" "ENSG00000162191" "UBXN1" "hsa:51035; Q04323; Q9BV93; Q9BVV5" "" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "2" "0" "1.200" "1.201" "1.105" "0.922" "0.721" "0.964" "0.668" "0.920" "1.408" "126.7" "152.1" "152.2" "140.1" "116.9" "91.4" "122.2" "84.7" "116.6" "178.5" "" "" "" "" "" "" "" "" "" "" "75.8" "79.1" "84.3" "65.8" "54.2" "46.8" "56.8" "38.0" "63.3" "178.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5375173174660804131" "False" "High" "IsMasterProtein" "Q16698" "2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial OS=Homo sapiens OX=9606 GN=DECR1 PE=1 SV=1" "0.000" "False" "14.781" "9" "3" "4" "3" "335" "36.0" "9.28" "13.73" "3" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf13561" "1666" "ENSG00000104325" "DECR1" "B7Z6B8; hsa:1666; Q16698; Q2M304; Q93085" "Fatty acid beta-oxidation; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling; Omega-6-fatty acids in senescence" "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" "5" "0" "0.981" "1.041" "1.024" "1.074" "1.015" "0.935" "0.897" "1.029" "0.858" "354.1" "347.4" "368.4" "362.6" "380.4" "359.5" "331.1" "317.5" "364.3" "303.9" "" "" "" "" "" "" "" "" "" "" "211.9" "180.5" "204.0" "170.2" "176.3" "184.1" "153.9" "142.6" "197.7" "303.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9215017324203505863" "False" "High" "IsMasterProtein" "Q6Y7W6" "GRB10-interacting GYF protein 2 OS=Homo sapiens OX=9606 GN=GIGYF2 PE=1 SV=1" "0.000" "False" "14.778" "4" "5" "5" "5" "1299" "150.0" "5.54" "8.63" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02213" "26058" "ENSG00000204120" "GIGYF2" "A6H8W4; B9EG55; E9PBB0; hsa:26058; O75137; Q6Y7W6; Q7Z2Z8; Q7Z3I2; Q96HU4; Q9NV82" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.996" "0.791" "1.420" "1.193" "0.832" "1.618" "1.164" "1.084" "1.693" "46.3" "46.1" "36.6" "65.7" "55.2" "38.5" "74.9" "53.9" "50.2" "78.4" "" "" "" "" "" "" "" "" "" "" "27.7" "24.0" "20.3" "30.9" "25.6" "19.7" "34.8" "24.2" "27.2" "78.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "565785606400917725" "False" "High" "IsMasterProtein" "P26639" "Threonine--tRNA ligase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TARS1 PE=1 SV=3" "0.000" "False" "14.770" "7" "5" "8" "5" "723" "83.4" "6.67" "20.51" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf00587, Pf02824, Pf03129, Pf07973" "6897" "ENSG00000113407" "TARS1" "A8K8I1; B4DEG8; hsa:6897; P26639; Q96FP5; Q9BWA6" "" "Cytosolic tRNA aminoacylation" "1" "0" "0.858" "0.858" "1.053" "0.800" "0.993" "0.889" "0.729" "0.942" "2.770" "116.5" "100.0" "100.0" "122.7" "93.2" "115.7" "103.6" "84.9" "109.8" "322.8" "" "" "" "" "" "" "" "" "" "" "69.7" "51.9" "55.4" "57.6" "43.2" "59.2" "48.2" "38.1" "59.6" "322.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5442629486260098393" "False" "High" "IsMasterProtein" "Q05397" "Focal adhesion kinase 1 OS=Homo sapiens OX=9606 GN=PTK2 PE=1 SV=2" "0.000" "False" "14.767" "4" "5" "8" "5" "1052" "119.2" "6.62" "19.61" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00373, Pf03623, Pf07714, Pf18038, Pf21477" "5747" "ENSG00000169398" "PTK2" "B4E2N6; F5H4S4; hsa:5747; J3QT16; Q05397; Q14291; Q8IYN9; Q9UD85" "Androgen receptor signaling pathway; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Corticotropin-releasing hormone signaling pathway; Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Hepatocyte growth factor receptor signaling; Overview of nanoparticle effects; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; EGF/EGFR signaling pathway; Hippo-Merlin signaling dysregulation; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Small cell lung cancer; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; Pleural mesothelioma; Regulation of actin cytoskeleton; 2q13 copy number variation syndrome; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; 8q11.23 (RB1CC1) copy number variation; ErbB signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAF/MAP kinase cascade; Apoptotic cleavage of cellular proteins; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling; Signal regulatory protein family interactions; DCC mediated attractive signaling; VEGFA-VEGFR2 Pathway; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; MET activates PTK2 signaling; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins" "51" "0" "1.042" "1.025" "1.162" "1.145" "1.191" "1.060" "1.150" "1.225" "1.139" "690.9" "720.2" "707.8" "803.0" "791.4" "822.8" "732.2" "794.5" "846.6" "786.6" "" "" "" "" "" "" "" "" "" "" "413.5" "374.3" "392.0" "377.0" "366.8" "421.2" "340.5" "356.7" "459.3" "786.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6529775950404904251" "False" "High" "IsMasterProtein" "Q9UBC2" "Epidermal growth factor receptor substrate 15-like 1 OS=Homo sapiens OX=9606 GN=EPS15L1 PE=1 SV=1" "0.000" "False" "14.767" "6" "5" "6" "5" "864" "94.2" "5.11" "16.22" "5" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12763" "58513" "ENSG00000127527" "EPS15L1" "A2RRF3; A5PL29; B4DKA3; hsa:58513; Q9UBC2" "EGF/EGFR signaling pathway" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation" "4" "0" "1.089" "1.117" "0.793" "1.038" "0.934" "0.900" "0.938" "1.035" "2.130" "51.8" "56.5" "57.9" "41.1" "53.8" "48.4" "46.6" "48.6" "53.6" "110.4" "" "" "" "" "" "" "" "" "" "" "31.0" "29.3" "32.1" "19.3" "24.9" "24.8" "21.7" "21.8" "29.1" "110.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7585773354798248656" "False" "High" "IsMasterProtein" "O60232" "Protein ZNRD2 OS=Homo sapiens OX=9606 GN=ZNRD2 PE=1 SV=1" "0.000" "False" "14.749" "8" "1" "2" "1" "199" "21.5" "5.24" "10.57" "1" "cell cycle OR cell proliferation;other biological processes" "" "" "Pf06677" "10534" "ENSG00000173465" "ZNRD2" "hsa:10534; O60232" "" "" "0" "0" "1.043" "1.180" "1.096" "1.116" "1.109" "1.217" "1.023" "1.277" "0.546" "92.5" "96.4" "109.1" "101.3" "103.2" "102.6" "112.5" "94.5" "118.1" "50.5" "" "" "" "" "" "" "" "" "" "" "55.3" "50.1" "60.4" "47.6" "47.8" "52.5" "52.3" "42.4" "64.0" "50.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5631999146533429965" "False" "High" "IsMasterProtein" "Q02878" "Large ribosomal subunit protein eL6 OS=Homo sapiens OX=9606 GN=RPL6 PE=1 SV=3" "0.000" "False" "14.748" "18" "6" "11" "6" "288" "32.7" "10.58" "26.47" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01159, Pf03868" "6128" "ENSG00000089009" "RPL6" "hsa:6128; Q02878; Q2M3Q3; Q8WW97" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.863" "0.820" "0.818" "0.863" "0.903" "0.713" "0.906" "0.797" "0.533" "383.1" "330.6" "314.2" "313.4" "330.6" "345.9" "273.1" "347.2" "305.4" "204.4" "" "" "" "" "" "" "" "" "" "" "229.3" "171.8" "174.0" "147.1" "153.3" "177.1" "127.0" "155.9" "165.7" "204.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4220399671961536759" "False" "High" "IsMasterProtein" "Q92918" "Mitogen-activated protein kinase kinase kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP4K1 PE=1 SV=1" "0.000" "False" "14.734" "7" "4" "4" "4" "833" "91.2" "8.34" "11.86" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069, Pf00780" "11184" "ENSG00000104814" "MAP4K1" "hsa:11184; Q92918" "Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Cardiac hypertrophic response; Hepatocyte growth factor receptor signaling; TGF-beta signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Modulators of TCR signaling and T cell activation; Pleural mesothelioma; T-cell receptor signaling pathway" "" "14" "0" "1.307" "1.065" "1.337" "1.190" "1.595" "1.407" "1.239" "1.275" "3.242" "110.7" "144.7" "118.0" "148.0" "131.8" "176.7" "155.9" "137.2" "141.2" "359.0" "" "" "" "" "" "" "" "" "" "" "66.3" "75.2" "65.3" "69.5" "61.1" "90.4" "72.5" "61.6" "76.6" "359.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7801299591553380074" "False" "High" "IsMasterProtein" "P52298" "Nuclear cap-binding protein subunit 2 OS=Homo sapiens OX=9606 GN=NCBP2 PE=1 SV=1" "0.000" "False" "14.669" "17" "3" "4" "3" "156" "18.0" "8.21" "12.41" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "22916" "ENSG00000114503" "NCBP2" "B2RE91; B4DMK7; E9PAR5; hsa:22916; P52298; Q14924; Q2TS50" "mRNA processing; 3q29 copy number variation syndrome" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; mRNA Capping; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; snRNP Assembly; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "29" "0" "1.027" "0.970" "0.941" "0.921" "1.007" "0.905" "0.861" "0.944" "1.399" "413.2" "424.4" "400.7" "388.8" "380.6" "416.3" "374.1" "355.9" "389.9" "578.1" "" "" "" "" "" "" "" "" "" "" "247.3" "220.6" "221.9" "182.5" "176.4" "213.1" "174.0" "159.8" "211.5" "578.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5053375512568543969" "False" "High" "IsMasterProtein" "Q0VDF9" "Heat shock 70 kDa protein 14 OS=Homo sapiens OX=9606 GN=HSPA14 PE=1 SV=1" "0.000" "False" "14.666" "8" "4" "5" "4" "509" "54.8" "5.59" "10.99" "4" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00012" "51182" "ENSG00000187522" "HSPA14" "A8K8F8; B0YIY9; hsa:51182; Q0VDF9; Q9P0X2; Q9UI07" "Parkin-ubiquitin proteasomal system pathway" "Regulation of HSF1-mediated heat shock response" "2" "0" "1.120" "0.926" "1.322" "1.310" "1.083" "1.034" "0.556" "1.199" "6.548" "52.3" "58.6" "48.5" "69.1" "68.5" "56.7" "54.1" "29.1" "62.7" "342.5" "" "" "" "" "" "" "" "" "" "" "31.3" "30.4" "26.8" "32.5" "31.8" "29.0" "25.2" "13.1" "34.0" "342.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5541205227018029514" "False" "High" "IsMasterProtein" "Q9H0P0" "Cytosolic 5'-nucleotidase 3A OS=Homo sapiens OX=9606 GN=NT5C3A PE=1 SV=3" "0.000" "False" "14.663" "12" "4" "6" "4" "336" "37.9" "7.12" "15.99" "4" "other metabolic processes;stress response" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf05822" "51251" "ENSG00000122643" "NT5C3A" "A8K253; B2RAA5; B8ZZC4; hsa:51251; Q6IPZ1; Q6NXS6; Q7L3G6; Q9H0P0; Q9P0P5; Q9UC42; Q9UC43; Q9UC44; Q9UC45" "" "" "0" "0" "0.981" "1.081" "1.432" "1.233" "1.200" "0.833" "0.305" "1.093" "6.267" "62.1" "61.0" "67.2" "89.0" "76.6" "74.6" "51.8" "19.0" "67.9" "389.5" "" "" "" "" "" "" "" "" "" "" "37.2" "31.7" "37.2" "41.8" "35.5" "38.2" "24.1" "8.5" "36.9" "389.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7347727386660618652" "False" "High" "IsMasterProtein" "Q8IUI8" "Cytokine receptor-like factor 3 OS=Homo sapiens OX=9606 GN=CRLF3 PE=1 SV=2" "0.000" "False" "14.655" "9" "4" "5" "4" "442" "49.7" "5.14" "11.92" "4" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "51379" "ENSG00000176390" "CRLF3" "A6NJF3; B2R8C3; hsa:51379; Q2MLY7; Q8IUI8; Q9UNI3; Q9Y6M8" "NF1 copy number variation syndrome" "" "1" "0" "1.269" "1.148" "1.403" "1.569" "1.359" "1.215" "0.411" "1.469" "11.475" "47.4" "60.2" "54.4" "66.5" "74.4" "64.4" "57.6" "19.5" "69.6" "544.0" "" "" "" "" "" "" "" "" "" "" "28.4" "31.3" "30.1" "31.2" "34.5" "33.0" "26.8" "8.7" "37.8" "544.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6145009283245857027" "False" "High" "IsMasterProtein" "P62487" "DNA-directed RNA polymerase II subunit RPB7 OS=Homo sapiens OX=9606 GN=POLR2G PE=1 SV=1" "0.000" "False" "14.654" "25" "4" "5" "4" "172" "19.3" "5.54" "13.74" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00575, Pf03876" "5436" "ENSG00000168002" "POLR2G" "B2R5C0; hsa:5436; P52433; P62487; Q2M1Z4" "Pyrimidine metabolism; Eukaryotic transcription initiation" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "43" "0" "0.982" "1.092" "1.026" "0.927" "1.196" "0.946" "1.277" "1.048" "0.754" "369.9" "363.2" "404.0" "379.3" "342.9" "442.2" "349.7" "472.5" "387.6" "278.8" "" "" "" "" "" "" "" "" "" "" "221.3" "188.7" "223.7" "178.1" "158.9" "226.4" "162.6" "212.1" "210.3" "278.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5278147799990617038" "False" "High" "IsMasterProtein" "P78318" "Immunoglobulin-binding protein 1 OS=Homo sapiens OX=9606 GN=IGBP1 PE=1 SV=1" "0.000" "False" "14.651" "12" "5" "5" "5" "339" "39.2" "5.38" "7.79" "5" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf04177" "3476" "ENSG00000089289" "IGBP1" "P78318; Q8TAB2" "16p11.2 proximal deletion syndrome" "" "1" "0" "1.073" "1.033" "0.978" "1.031" "0.881" "1.067" "0.844" "1.001" "1.872" "151.1" "162.1" "156.2" "147.8" "155.8" "133.2" "161.3" "127.5" "151.3" "283.0" "" "" "" "" "" "" "" "" "" "" "90.5" "84.3" "86.5" "69.4" "72.2" "68.2" "75.0" "57.2" "82.1" "283.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-564768690041684779" "False" "High" "IsMasterProtein" "Q9H0L4" "Cleavage stimulation factor subunit 2 tau variant OS=Homo sapiens OX=9606 GN=CSTF2T PE=1 SV=1" "0.000" "False" "14.650" "9" "5" "11" "1" "616" "64.4" "7.25" "19.45" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf14304, Pf14327" "23283" "ENSG00000177613" "CSTF2T" "B2RAR9; hsa:23283; O75174; Q53HK6; Q7LGE8; Q8N6T1; Q9H0L4" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7482655995969634953" "False" "High" "IsMasterProtein" "Q9Y237" "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 OS=Homo sapiens OX=9606 GN=PIN4 PE=1 SV=1" "0.000" "False" "14.641" "27" "3" "12" "3" "131" "13.8" "9.77" "22.56" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13616" "5303" "ENSG00000102309" "PIN4" "A8E0G6; B3KXM0; F5H1P5; hsa:5303; Q0D2H3; Q3MHV0; Q52M21; Q5HYW6; Q6IRW4; Q9Y237" "" "" "0" "0" "0.996" "1.013" "1.047" "1.042" "1.037" "0.998" "1.020" "0.998" "0.865" "484.5" "482.7" "491.0" "507.2" "505.0" "502.2" "483.5" "494.3" "483.7" "419.3" "" "" "" "" "" "" "" "" "" "" "290.0" "250.8" "271.9" "238.1" "234.1" "257.1" "224.8" "221.9" "262.4" "419.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5762043181650020657" "False" "High" "IsMasterProtein" "P46109" "Crk-like protein OS=Homo sapiens OX=9606 GN=CRKL PE=1 SV=1" "0.000" "False" "14.585" "17" "4" "5" "4" "303" "33.8" "6.74" "12.28" "4" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00018, Pf07653" "1399" "ENSG00000099942" "CRKL" "A8KA44; D3DX35; hsa:1399; P46109" "Androgen receptor network in prostate cancer; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; EGF/EGFR signaling pathway; 22q11.2 copy number variation syndrome; IL-2 signaling pathway; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "Downstream signal transduction; Frs2-mediated activation; Regulation of signaling by CBL; Erythropoietin activates RAS; MET activates RAP1 and RAC1; MET receptor recycling" "22" "0" "1.097" "1.025" "1.169" "1.179" "0.981" "1.004" "1.115" "1.098" "1.691" "107.4" "117.8" "110.1" "125.5" "126.6" "105.4" "107.8" "119.7" "117.9" "181.6" "" "" "" "" "" "" "" "" "" "" "64.3" "61.2" "61.0" "58.9" "58.7" "53.9" "50.1" "53.8" "64.0" "181.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-34001002036977343" "False" "High" "IsMasterProtein" "O76003" "Glutaredoxin-3 OS=Homo sapiens OX=9606 GN=GLRX3 PE=1 SV=2" "0.000" "False" "14.575" "10" "3" "6" "3" "335" "37.4" "5.39" "16.87" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00085, Pf00462" "10539" "ENSG00000108010" "GLRX3" "B3KMP7; B3KMQ5; D3DRG2; hsa:10539; O76003; Q5JV01; Q96CE0; Q9P1B0; Q9P1B1" "" "Iron uptake and transport" "1" "0" "1.012" "1.288" "0.931" "1.070" "1.086" "0.818" "0.746" "1.283" "3.292" "150.9" "152.8" "194.4" "140.6" "161.5" "163.8" "123.5" "112.5" "193.6" "496.8" "" "" "" "" "" "" "" "" "" "" "90.3" "79.4" "107.7" "66.0" "74.9" "83.9" "57.4" "50.5" "105.0" "496.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-61842363996650095" "False" "High" "IsMasterProtein" "P19623" "Spermidine synthase OS=Homo sapiens OX=9606 GN=SRM PE=1 SV=1" "0.000" "False" "14.568" "10" "3" "17" "3" "302" "33.8" "5.49" "39.92" "3" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01564, Pf17284" "6723" "ENSG00000116649" "SRM" "B1AKP9; hsa:6723; P19623; Q15511" "Methionine de novo and salvage pathway; Amino acid metabolism" "Metabolism of polyamines" "3" "0" "1.158" "1.135" "1.266" "1.138" "1.059" "1.187" "0.532" "1.083" "5.913" "300.3" "347.7" "340.8" "380.0" "341.6" "318.0" "356.3" "159.7" "325.2" "1775.6" "" "" "" "" "" "" "" "" "" "" "179.7" "180.7" "188.7" "178.4" "158.4" "162.8" "165.7" "71.7" "176.4" "1775.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4683582367495080514" "False" "High" "IsMasterProtein" "Q6IA86" "Elongator complex protein 2 OS=Homo sapiens OX=9606 GN=ELP2 PE=1 SV=2" "0.000" "False" "14.568" "6" "5" "7" "5" "826" "92.4" "5.96" "11.42" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "55250" "ENSG00000134759" "ELP2" "A8KAI6; B4DTG0; B4DXP0; E7EP23; E9PCX0; Q53GZ0; Q687Y8; Q6IA86; Q8N5C2; Q96GV4; Q96PI7; Q9H9N0; Q9NV81" "" "HATs acetylate histones" "1" "0" "1.028" "0.877" "0.908" "0.973" "1.275" "1.013" "1.029" "1.078" "1.400" "56.1" "57.6" "49.2" "50.9" "54.6" "71.5" "56.8" "57.7" "60.5" "78.5" "" "" "" "" "" "" "" "" "" "" "33.6" "30.0" "27.2" "23.9" "25.3" "36.6" "26.4" "25.9" "32.8" "78.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2438255133986472284" "False" "High" "IsMasterProtein" "Q9H8H0" "Nucleolar protein 11 OS=Homo sapiens OX=9606 GN=NOL11 PE=1 SV=1" "0.000" "False" "14.553" "7" "5" "8" "5" "719" "81.1" "6.07" "19.82" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf08168, Pf20998" "25926" "ENSG00000130935" "NOL11" "B7Z5V9; hsa:25926; Q7L5S1; Q9H8H0; Q9UG18" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.983" "0.981" "0.997" "1.011" "1.087" "0.965" "1.028" "0.940" "0.591" "547.4" "538.2" "537.0" "545.8" "553.6" "595.0" "528.5" "563.0" "514.6" "323.5" "" "" "" "" "" "" "" "" "" "" "327.6" "279.7" "297.4" "256.2" "256.6" "304.6" "245.7" "252.8" "279.2" "323.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "672780113730382771" "False" "High" "IsMasterProtein" "Q99952" "Tyrosine-protein phosphatase non-receptor type 18 OS=Homo sapiens OX=9606 GN=PTPN18 PE=1 SV=2" "0.000" "False" "14.539" "9" "3" "6" "3" "460" "50.5" "8.25" "13.43" "3" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00102" "26469" "ENSG00000072135" "PTPN18" "B4E1E6; hsa:26469; Q53P42; Q99952" "B cell receptor signaling pathway" "Downregulation of ERBB2 signaling; Interleukin-37 signaling" "3" "0" "1.152" "0.892" "0.893" "1.090" "0.932" "0.882" "0.976" "0.988" "0.377" "71.5" "82.3" "63.8" "63.8" "77.9" "66.6" "63.0" "69.8" "70.6" "27.0" "" "" "" "" "" "" "" "" "" "" "42.8" "42.8" "35.3" "30.0" "36.1" "34.1" "29.3" "31.3" "38.3" "27.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5798091253452066801" "False" "High" "IsMasterProtein" "Cont_Q86YZ3" "Hornerin OS=Homo sapiens OX=9606 GN=HRNR PE=1 SV=2" "0.000" "True" "14.539" "5" "4" "4" "4" "2850" "282.2" "10.04" "6.18" "4" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01023" "388697" "ENSG00000197915" "HRNR" "hsa:388697; Q5DT20; Q5U1F4; Q86YZ3" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "609844474726423505" "False" "High" "IsMasterProtein" "P63279" "SUMO-conjugating enzyme UBC9 OS=Homo sapiens OX=9606 GN=UBE2I PE=1 SV=1" "0.000" "False" "14.509" "19" "3" "7" "3" "158" "18.0" "8.66" "22.82" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7329" "ENSG00000103275" "UBE2I" "D3DU69; P50550; P63279; Q15698; Q59GX1; Q86VB3" "Androgen receptor signaling pathway; TGF-beta signaling pathway; TAR syndrome" "Formation of Incision Complex in GG-NER; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Meiotic synapsis; PKR-mediated signaling; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Processing of DNA double-strand break ends; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; SUMOylation of nuclear envelope proteins; Maturation of nucleoprotein; SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "27" "0" "1.080" "1.089" "0.938" "1.141" "0.953" "0.910" "1.011" "0.997" "1.357" "202.0" "218.3" "220.0" "189.5" "230.4" "192.4" "183.8" "204.3" "201.3" "274.1" "" "" "" "" "" "" "" "" "" "" "120.9" "113.4" "121.8" "89.0" "106.8" "98.5" "85.5" "91.7" "109.2" "274.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5740436620154947735" "False" "High" "IsMasterProtein" "Q9BX68" "Adenosine 5'-monophosphoramidase HINT2 OS=Homo sapiens OX=9606 GN=HINT2 PE=1 SV=1" "0.000" "False" "14.503" "20" "3" "5" "3" "163" "17.2" "9.16" "15.46" "3" "other metabolic processes;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01230" "84681" "ENSG00000137133" "HINT2" "hsa:84681; Q5TCW3; Q9BX68" "" "RHOD GTPase cycle" "1" "0" "1.022" "0.912" "1.157" "1.071" "1.051" "1.096" "1.125" "1.271" "0.666" "224.3" "229.2" "204.6" "259.5" "240.2" "235.8" "245.8" "252.4" "285.0" "149.4" "" "" "" "" "" "" "" "" "" "" "134.2" "119.1" "113.3" "121.8" "111.3" "120.7" "114.3" "113.3" "154.7" "149.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8491275537287957660" "False" "High" "IsMasterProtein" "Q8NDD1" "Uncharacterized protein C1orf131 OS=Homo sapiens OX=9606 GN=C1orf131 PE=1 SV=4" "0.000" "False" "14.497" "13" "4" "5" "4" "293" "32.6" "9.88" "13.47" "4" "other biological processes" "nucleus;other cell component" "" "Pf15375" "128061" "ENSG00000143633" "C1orf131" "Q5TBI0; Q5TBI1; Q6P6B4; Q7Z6H5; Q8N432; Q8NDD1; Q96NM6" "" "" "0" "0" "0.979" "0.982" "0.999" "1.030" "0.963" "1.132" "1.164" "1.054" "0.485" "224.1" "219.5" "220.0" "223.8" "230.9" "215.7" "253.7" "260.8" "236.1" "108.7" "" "" "" "" "" "" "" "" "" "" "134.1" "114.0" "121.8" "105.1" "107.0" "110.4" "118.0" "117.1" "128.1" "108.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8489357358395881882" "False" "High" "IsMasterProtein" "Q86SX6" "Glutaredoxin-related protein 5, mitochondrial OS=Homo sapiens OX=9606 GN=GLRX5 PE=1 SV=2" "0.000" "False" "14.487" "20" "3" "8" "3" "157" "16.6" "6.79" "20.72" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00462" "51218" "ENSG00000182512" "GLRX5" "hsa:51218; Q0X088; Q3YML0; Q86SX6; Q86WY3; Q8IZ54" "Iron-sulfur cluster biogenesis" "Mitochondrial iron-sulfur cluster biogenesis" "2" "0" "0.966" "0.930" "0.933" "1.215" "1.067" "1.022" "1.035" "0.987" "0.696" "358.8" "346.5" "333.7" "334.7" "435.9" "382.7" "366.6" "371.4" "354.0" "249.6" "" "" "" "" "" "" "" "" "" "" "214.7" "180.0" "184.8" "157.2" "202.1" "195.9" "170.5" "166.7" "192.0" "249.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2714329419910624829" "False" "High" "IsMasterProtein" "P47985" "Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRFS1 PE=1 SV=2" "0.000" "False" "14.459" "11" "3" "4" "3" "274" "29.6" "8.32" "13.66" "3" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00355, Pf02921, Pf09165" "7386" "ENSG00000169021" "UQCRFS1" "A8K519; hsa:7386; P47985; Q6NVX5; Q9UPH2" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly; Iron metabolism disorders; Arsenic metabolism and reactive oxygen species generation" "Respiratory electron transport" "6" "0" "1.062" "1.241" "1.306" "1.309" "1.271" "1.190" "1.196" "1.042" "1.089" "103.3" "109.8" "128.3" "135.0" "135.2" "131.3" "123.0" "123.6" "107.6" "112.5" "" "" "" "" "" "" "" "" "" "" "61.8" "57.0" "71.0" "63.4" "62.7" "67.2" "57.2" "55.5" "58.4" "112.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4811509789942253503" "False" "High" "IsMasterProtein" "Q7Z6M1" "Rab9 effector protein with kelch motifs OS=Homo sapiens OX=9606 GN=RABEPK PE=1 SV=1" "0.000" "False" "14.456" "13" "4" "11" "4" "372" "40.5" "6.25" "30.70" "4" "transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01344, Pf07646, Pf13415" "10244" "ENSG00000136933" "RABEPK" "A8K403; hsa:10244; O00568; Q69YR2; Q6FHA4; Q6IBG7; Q6P092; Q7Z6M1; Q86Y76; Q9BWB1" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "1.068" "0.945" "1.146" "1.027" "1.012" "1.079" "0.944" "0.990" "0.865" "282.4" "301.5" "266.8" "323.5" "290.1" "285.9" "304.8" "266.7" "279.7" "244.1" "" "" "" "" "" "" "" "" "" "" "169.0" "156.7" "147.7" "151.9" "134.5" "146.3" "141.7" "119.7" "151.7" "244.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5083710564544014092" "False" "High" "IsMasterProtein" "P84103" "Serine/arginine-rich splicing factor 3 OS=Homo sapiens OX=9606 GN=SRSF3 PE=1 SV=1" "0.000" "False" "14.436" "23" "4" "15" "3" "164" "19.3" "11.65" "39.17" "4" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6428" "ENSG00000112081" "SRSF3" "B4E241; hsa:6428; O08831; P23152; P84103; Q5R3K0" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "6" "0" "0.964" "1.026" "0.864" "0.944" "0.781" "0.829" "0.894" "0.840" "0.581" "1982.7" "1911.8" "2035.0" "1713.0" "1872.0" "1548.4" "1643.1" "1772.5" "1665.7" "1152.9" "" "" "" "" "" "" "" "" "" "" "1186.5" "993.5" "1127.0" "804.2" "867.7" "792.7" "764.0" "795.7" "903.7" "1152.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7727744455345483682" "False" "High" "IsMasterProtein" "Q13868" "Exosome complex component RRP4 OS=Homo sapiens OX=9606 GN=EXOSC2 PE=1 SV=2" "0.000" "False" "14.434" "14" "4" "7" "4" "293" "32.8" "7.50" "22.77" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf14382, Pf15985, Pf21266" "23404" "ENSG00000130713" "EXOSC2" "A3KFL3; A3KFL4; B4DKK6; hsa:23404; Q13868; Q9NUY4" "Ciliary landscape" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "7" "0" "1.006" "1.039" "1.092" "1.246" "1.236" "1.062" "1.224" "1.051" "0.621" "238.7" "240.1" "247.9" "260.7" "297.4" "295.0" "253.5" "292.2" "250.9" "148.3" "" "" "" "" "" "" "" "" "" "" "142.8" "124.8" "137.3" "122.4" "137.8" "151.0" "117.9" "131.2" "136.1" "148.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8857038607970442570" "False" "High" "IsMasterProtein" "Q16836" "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HADH PE=1 SV=3" "0.000" "False" "14.412" "13" "5" "8" "5" "314" "34.3" "8.85" "18.22" "5" "other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00725, Pf02737" "3033" "ENSG00000138796" "HADH" "hsa:3033; J3KQ17; O00324; O00397; O00753; Q16836; Q4W5B4" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; Amino acid metabolism; IL-18 signaling pathway; Mitochondrial fatty acid oxidation disorders" "Mitochondrial protein degradation; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA" "12" "0" "1.096" "1.071" "1.000" "0.900" "1.034" "0.976" "1.016" "0.982" "1.007" "548.3" "601.2" "587.3" "548.3" "493.4" "566.7" "535.3" "557.2" "538.5" "552.1" "" "" "" "" "" "" "" "" "" "" "328.1" "312.4" "325.2" "257.4" "228.7" "290.1" "248.9" "250.2" "292.1" "552.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2305631654265975414" "False" "High" "IsMasterProtein" "Q96E11" "Ribosome-recycling factor, mitochondrial OS=Homo sapiens OX=9606 GN=MRRF PE=1 SV=1" "0.000" "False" "14.402" "19" "4" "4" "4" "262" "29.3" "9.79" "10.65" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "translation activity" "Pf01765" "92399" "ENSG00000148187" "MRRF" "A8K6D8; A8K6Z4; B7Z4X5; B7Z6P7; hsa:92399; Q5RKT1; Q5T7T0; Q5T7T1; Q5T7T2; Q5T7T3; Q5T7T4; Q5T7T5; Q96E11" "" "Mitochondrial translation termination" "1" "0" "1.007" "0.948" "1.123" "1.113" "1.112" "1.045" "0.935" "1.006" "1.425" "196.4" "197.7" "186.2" "220.5" "218.5" "218.4" "205.1" "183.7" "197.5" "279.8" "" "" "" "" "" "" "" "" "" "" "117.5" "102.7" "103.1" "103.5" "101.3" "111.8" "95.4" "82.4" "107.1" "279.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6956886752181187117" "False" "High" "IsMasterProtein" "P55039" "Developmentally-regulated GTP-binding protein 2 OS=Homo sapiens OX=9606 GN=DRG2 PE=1 SV=1" "0.000" "False" "14.395" "13" "5" "8" "4" "364" "40.7" "8.88" "23.51" "5" "protein metabolism;other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01926, Pf02824, Pf16897" "1819" "ENSG00000108591" "DRG2" "B2R8G5; hsa:1819; P55039; Q53Y50; Q9BWB2" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Protein hydroxylation" "2" "0" "1.025" "1.056" "1.164" "1.131" "1.216" "1.163" "1.146" "1.186" "1.675" "278.9" "285.9" "294.5" "324.6" "315.5" "339.0" "324.3" "319.5" "330.8" "467.3" "" "" "" "" "" "" "" "" "" "" "166.9" "148.6" "163.1" "152.4" "146.3" "173.6" "150.8" "143.5" "179.5" "467.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7232907791819213920" "False" "High" "IsMasterProtein" "Q9Y5Z4" "Heme-binding protein 2 OS=Homo sapiens OX=9606 GN=HEBP2 PE=1 SV=1" "0.000" "False" "14.384" "12" "2" "3" "2" "205" "22.9" "4.63" "11.04" "2" "" "non-structural extracellular;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04832" "23593" "ENSG00000051620" "HEBP2" "hsa:23593; Q96P57; Q9Y5Z4" "" "Neutrophil degranulation" "1" "0" "0.929" "0.946" "0.949" "0.969" "1.039" "0.989" "0.969" "1.032" "0.717" "239.9" "222.9" "227.0" "227.6" "232.4" "249.2" "237.2" "232.5" "247.4" "171.9" "" "" "" "" "" "" "" "" "" "" "143.5" "115.8" "125.7" "106.8" "107.7" "127.6" "110.3" "104.4" "134.2" "171.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4995035234308884546" "False" "High" "IsMasterProtein" "Q9Y6B6" "Small COPII coat GTPase SAR1B OS=Homo sapiens OX=9606 GN=SAR1B PE=1 SV=1" "0.000" "False" "14.349" "15" "3" "7" "1" "198" "22.4" "6.11" "20.75" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00025" "51128" "ENSG00000152700" "SAR1B" "D3DQA4; hsa:51128; Q567T4; Q9Y6B6" "Sterol regulatory element-binding proteins (SREBP) signaling; Cholesterol metabolism; Enterocyte cholesterol metabolism" "MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Chylomicron assembly" "10" "2" "1.004" "0.843" "0.963" "1.157" "1.157" "1.457" "1.013" "0.978" "1.510" "308.2" "309.3" "259.7" "296.8" "356.6" "356.7" "449.1" "312.1" "301.3" "465.3" "" "" "" "" "" "" "" "" "" "" "184.4" "160.7" "143.8" "139.3" "165.3" "182.6" "208.8" "140.1" "163.5" "465.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8898508644132712333" "False" "High" "IsMasterProtein" "Q01130" "Serine/arginine-rich splicing factor 2 OS=Homo sapiens OX=9606 GN=SRSF2 PE=1 SV=4" "0.000" "False" "14.349" "28" "6" "8" "6" "221" "25.5" "11.85" "15.15" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "6427" "ENSG00000161547" "SRSF2" "B3KWD5; B4DN89; H0YG49; hsa:6427; Q01130" "mRNA processing" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "7" "0" "0.917" "0.946" "0.972" "1.029" "0.939" "0.958" "0.920" "0.759" "0.647" "282.4" "258.9" "267.0" "274.5" "290.5" "265.1" "270.6" "259.8" "214.4" "182.8" "" "" "" "" "" "" "" "" "" "" "169.0" "134.6" "147.9" "128.9" "134.7" "135.7" "125.8" "116.6" "116.3" "182.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5541233720560719878" "False" "High" "IsMasterProtein" "O43809" "Cleavage and polyadenylation specificity factor subunit 5 OS=Homo sapiens OX=9606 GN=NUDT21 PE=1 SV=1" "0.000" "False" "14.328" "21" "5" "18" "5" "227" "26.2" "8.82" "44.31" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13869" "11051" "ENSG00000167005" "NUDT21" "hsa:11051; O43809; Q6IB85; Q6NE84" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.099" "1.139" "1.044" "1.049" "0.972" "1.076" "1.025" "1.064" "0.616" "573.0" "630.0" "652.7" "598.0" "600.8" "557.1" "616.8" "587.3" "609.5" "353.1" "" "" "" "" "" "" "" "" "" "" "342.9" "327.4" "361.5" "280.7" "278.5" "285.2" "286.8" "263.7" "330.7" "353.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9139245110499108060" "False" "High" "IsMasterProtein" "P32942" "Intercellular adhesion molecule 3 OS=Homo sapiens OX=9606 GN=ICAM3 PE=1 SV=2" "0.000" "False" "14.325" "10" "5" "7" "5" "547" "59.5" "5.43" "11.03" "5" "cell adhesion;transport" "plasma membrane;other membranes" "signal transduction activity or receptor binding" "Pf03921, Pf21146" "3385" "ENSG00000076662" "ICAM3" "hsa:3385; P32942; Q6PD68" "Ebola virus infection in host" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; CD209 (DC-SIGN) signaling" "4" "0" "1.241" "1.149" "1.290" "1.048" "0.988" "1.706" "1.456" "1.220" "0.763" "34.0" "42.2" "39.1" "43.9" "35.7" "33.6" "58.0" "49.5" "41.5" "26.0" "" "" "" "" "" "" "" "" "" "" "20.4" "21.9" "21.6" "20.6" "16.5" "17.2" "27.0" "22.2" "22.5" "26.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4143955501491186019" "False" "High" "IsMasterProtein" "P55084" "Trifunctional enzyme subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=HADHB PE=1 SV=3" "0.000" "False" "14.313" "8" "4" "7" "4" "474" "51.3" "9.41" "22.75" "4" "other metabolic processes;other biological processes" "other membranes;mitochondrion;ER/Golgi" "nucleic acid binding activity;other molecular function" "Pf00108, Pf02803" "3032" "ENSG00000138029" "HADHB" "B2RB16; B4E2W0; hsa:3032; O14969; P55084; Q53TA6; Q96C77; Q9H3F5; Q9T2V8" "Fatty acid beta-oxidation; Valproic acid pathway; Female steroid hormones in cardiomyocyte energy metabolism; Sudden infant death syndrome (SIDS) susceptibility pathways" "Acyl chain remodeling of CL; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "12" "0" "0.989" "1.186" "1.015" "1.031" "1.231" "1.176" "0.897" "1.013" "4.363" "201.3" "199.2" "238.7" "204.2" "207.6" "247.7" "236.7" "180.5" "203.9" "878.3" "" "" "" "" "" "" "" "" "" "" "120.5" "103.5" "132.2" "95.9" "96.2" "126.8" "110.0" "81.0" "110.7" "878.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1585562482268553685" "False" "High" "IsMasterProtein" "O15372" "Eukaryotic translation initiation factor 3 subunit H OS=Homo sapiens OX=9606 GN=EIF3H PE=1 SV=1" "0.000" "False" "14.299" "14" "4" "5" "4" "352" "39.9" "6.54" "8.71" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf19445" "8667" "ENSG00000147677" "EIF3H" "hsa:8667; O15372" "Translation factors; VEGFA-VEGFR2 signaling; Measles virus infection; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "10" "0" "0.959" "1.186" "0.940" "1.207" "1.003" "0.916" "0.965" "0.977" "2.264" "112.4" "107.8" "133.3" "105.7" "135.7" "112.7" "103.0" "108.5" "109.8" "254.5" "" "" "" "" "" "" "" "" "" "" "67.3" "56.0" "73.8" "49.6" "62.9" "57.7" "47.9" "48.7" "59.6" "254.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6803776007100694472" "False" "High" "IsMasterProtein" "P51580" "Thiopurine S-methyltransferase OS=Homo sapiens OX=9606 GN=TPMT PE=1 SV=1" "0.000" "False" "14.295" "19" "5" "13" "5" "245" "28.2" "6.23" "34.38" "5" "other metabolic processes" "cytosol" "other molecular function" "Pf05724" "7172" "ENSG00000137364" "TPMT" "hsa:7172; O14806; O15423; O15424; O15425; O15426; O15515; O15548; O43213; P51580; Q5VUK6; Q9UBE6; Q9UBT8; Q9UE62" "Metapathway biotransformation Phase I and II; Methylation pathways" "Azathioprine ADME; Methylation; Defective TPMT causes TPMT deficiency" "5" "0" "0.996" "1.027" "1.082" "0.945" "0.997" "1.010" "1.054" "0.951" "0.769" "892.7" "889.5" "917.1" "966.2" "843.3" "889.8" "901.3" "940.9" "849.2" "686.8" "" "" "" "" "" "" "" "" "" "" "534.2" "462.3" "507.9" "453.6" "390.9" "455.5" "419.1" "422.4" "460.7" "686.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6425786624467733847" "False" "High" "IsMasterProtein" "O95758" "Polypyrimidine tract-binding protein 3 OS=Homo sapiens OX=9606 GN=PTBP3 PE=1 SV=2" "0.000" "False" "14.286" "5" "3" "7" "1" "552" "59.7" "9.04" "22.23" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf11835, Pf13893" "9991" "ENSG00000119314" "PTBP3" "B1ALY2; B1ALY3; B1ALY5; B1ALY6; B3KME7; hsa:9991; O95758; Q68DB9; Q86YB3; Q86YH9" "" "" "0" "0" "1.649" "1.331" "1.226" "1.022" "1.816" "1.693" "0.010" "1.177" "37.852" "13.2" "21.7" "17.5" "16.1" "13.4" "23.9" "22.3" "0.0" "15.5" "498.0" "" "" "" "" "" "" "" "" "" "" "7.9" "11.3" "9.7" "7.6" "6.2" "12.2" "10.4" "0.0" "8.4" "498.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "Not Found" "High" "High" "1" "" "3245672403803654152" "False" "High" "IsMasterProtein" "P62263" "Small ribosomal subunit protein uS11 OS=Homo sapiens OX=9606 GN=RPS14 PE=1 SV=3" "0.000" "False" "14.280" "36" "4" "7" "4" "151" "16.3" "10.05" "18.71" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00411" "6208" "ENSG00000164587" "RPS14" "B2R5G5; D3DQG5; hsa:6208; P06366; P62263; Q5BJI0" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; rRNA modification in the nucleus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "20" "0" "0.951" "1.057" "1.068" "0.886" "1.006" "0.894" "0.837" "1.076" "2.682" "203.8" "193.9" "215.4" "217.7" "180.6" "205.1" "182.3" "170.7" "219.4" "546.7" "" "" "" "" "" "" "" "" "" "" "122.0" "100.7" "119.3" "102.2" "83.7" "105.0" "84.8" "76.6" "119.0" "546.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4066776278631376418" "False" "High" "IsMasterProtein" "P17612" "cAMP-dependent protein kinase catalytic subunit alpha OS=Homo sapiens OX=9606 GN=PRKACA PE=1 SV=2" "0.000" "False" "14.259" "13" "5" "6" "5" "351" "40.6" "8.79" "16.62" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5566" "ENSG00000072062; ENSG00000288516" "PRKACA" "hsa:5566; P17612; Q32P54; Q9H2Y0; Q9NRB4; Q9NRH9" "Nicotine effect on dopaminergic neurons; Sterol regulatory element-binding proteins (SREBP) signaling; Follicle stimulating hormone (FSH) signaling pathway; Microtubule cytoskeleton regulation; Dopamine metabolism; Common pathways underlying drug addiction; Complement system; Mesodermal commitment pathway; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mesodermal commitment pathway; G protein signaling pathways; MAPK signaling pathway; Cannabinoid receptor signaling; Lipid metabolism pathway; Phosphodiesterases in neuronal function; Ras signaling; Hedgehog signaling pathway; Thermogenesis; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Vasopressin-regulated water reabsorption; GDNF signaling; Urotensin-II-mediated signaling pathway; Calcium regulation in cardiac cells; KCNQ2-related epilepsies; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway" "Mitochondrial protein degradation; FCGR3A-mediated IL10 synthesis; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Triglyceride catabolism; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Ion homeostasis; Interleukin-3, Interleukin-5 and GM-CSF signaling; RET signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; Regulation of MECP2 expression and activity; PKA activation; PKA activation in glucagon signalling; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; CD209 (DC-SIGN) signaling; Rap1 signalling; HDL assembly; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; Loss of phosphorylation of MECP2 at T308; ROBO receptors bind AKAP5; PKA-mediated phosphorylation of key metabolic factors" "75" "0" "0.980" "0.901" "1.077" "0.871" "0.989" "1.077" "1.053" "1.122" "1.383" "443.0" "434.0" "399.3" "476.9" "385.7" "437.9" "477.0" "466.4" "497.0" "612.6" "" "" "" "" "" "" "" "" "" "" "265.1" "225.5" "221.1" "223.9" "178.8" "224.2" "221.8" "209.4" "269.7" "612.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7397667510889778360" "False" "High" "IsMasterProtein" "Q9H4X1" "Regulator of cell cycle RGCC OS=Homo sapiens OX=9606 GN=RGCC PE=1 SV=1" "0.000" "False" "14.255" "37" "3" "3" "3" "137" "14.6" "4.75" "11.04" "3" "cell cycle OR cell proliferation;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf15151" "28984" "ENSG00000102760" "RGCC" "hsa:28984; Q6NZ48; Q9H4X1; Q9UL69" "" "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9025151423134884799" "False" "High" "IsMasterProtein" "Q9BY42" "Replication termination factor 2 OS=Homo sapiens OX=9606 GN=RTF2 PE=1 SV=3" "0.000" "False" "14.252" "16" "5" "5" "5" "306" "33.9" "8.59" "12.96" "5" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04641" "51507" "ENSG00000022277" "RTF2" "E1P5Z9; hsa:51507; Q9BY42; Q9BYL7; Q9HCV9; Q9NX29; Q9NZZ8; Q9P002; Q9UHW3" "" "" "0" "0" "0.878" "1.162" "1.115" "1.202" "1.011" "0.995" "1.135" "1.128" "1.041" "226.0" "198.4" "262.7" "252.1" "271.7" "228.6" "224.9" "256.6" "255.0" "235.4" "" "" "" "" "" "" "" "" "" "" "135.3" "103.1" "145.4" "118.4" "125.9" "117.0" "104.6" "115.2" "138.3" "235.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "61926280635528933" "False" "High" "IsMasterProtein" "O60885" "Bromodomain-containing protein 4 OS=Homo sapiens OX=9606 GN=BRD4 PE=1 SV=2" "0.000" "False" "14.247" "3" "4" "4" "4" "1362" "152.1" "9.19" "12.51" "4" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00439, Pf17035, Pf17105" "23476" "ENSG00000141867" "BRD4" "hsa:23476; O60433; O60885; Q4G0X8; Q86YS8; Q96PD3" "VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome" "Potential therapeutics for SARS" "3" "0" "1.009" "0.936" "1.113" "1.148" "1.010" "1.124" "0.841" "1.160" "3.422" "118.5" "119.5" "110.9" "131.9" "136.0" "119.6" "133.2" "99.7" "137.4" "405.5" "" "" "" "" "" "" "" "" "" "" "70.9" "62.1" "61.4" "61.9" "63.1" "61.2" "61.9" "44.7" "74.6" "405.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5188184621199488866" "False" "High" "IsMasterProtein" "Q9GZT3" "SRA stem-loop-interacting RNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SLIRP PE=1 SV=1" "0.000" "False" "14.240" "39" "4" "5" "4" "109" "12.3" "10.24" "15.01" "4" "other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "" "Pf00076" "81892" "ENSG00000119705" "SLIRP" "hsa:81892; J3KMY7; Q9GZT3" "" "Mitochondrial RNA degradation" "1" "0" "0.883" "0.838" "0.921" "1.136" "0.980" "0.900" "0.392" "1.003" "6.058" "115.8" "102.2" "97.1" "106.6" "131.6" "113.5" "104.2" "45.4" "116.1" "701.5" "" "" "" "" "" "" "" "" "" "" "69.3" "53.1" "53.8" "50.0" "61.0" "58.1" "48.4" "20.4" "63.0" "701.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2794156240078795368" "False" "High" "IsMasterProtein" "Q8NEZ5" "F-box only protein 22 OS=Homo sapiens OX=9606 GN=FBXO22 PE=1 SV=1" "0.000" "False" "14.239" "16" "6" "7" "6" "403" "44.5" "7.03" "10.86" "6" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00646, Pf10442" "26263" "ENSG00000167196" "FBXO22" "hsa:26263; Q0D2P8; Q6PIL5; Q8IXW3; Q8NEZ5; Q9H824; Q9UKC0" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.065" "1.045" "1.066" "1.025" "0.997" "1.039" "1.193" "1.197" "0.852" "117.8" "125.5" "123.1" "125.6" "120.8" "117.5" "122.5" "140.6" "141.0" "100.4" "" "" "" "" "" "" "" "" "" "" "70.5" "65.2" "68.2" "59.0" "56.0" "60.2" "56.9" "63.1" "76.5" "100.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7029493779746441827" "False" "High" "IsMasterProtein" "Q7L1Q6" "eIF5-mimic protein 2 OS=Homo sapiens OX=9606 GN=BZW1 PE=1 SV=1" "0.000" "False" "14.219" "10" "5" "6" "5" "419" "48.0" "5.92" "16.55" "5" "other biological processes" "other cell component" "" "Pf02020" "9689" "ENSG00000082153" "BZW1" "B4DLZ8; B4DWF7; hsa:9689; Q14281; Q15394; Q7L1Q6; Q9BUY0" "" "" "0" "0" "1.102" "1.166" "1.048" "1.218" "1.107" "0.994" "0.374" "1.026" "11.012" "207.7" "228.9" "242.3" "217.7" "252.9" "229.9" "206.6" "77.7" "213.0" "2287.5" "" "" "" "" "" "" "" "" "" "" "124.3" "118.9" "134.2" "102.2" "117.2" "117.7" "96.0" "34.9" "115.6" "2287.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5783897718523636057" "False" "High" "IsMasterProtein" "O95602" "DNA-directed RNA polymerase I subunit RPA1 OS=Homo sapiens OX=9606 GN=POLR1A PE=1 SV=2" "0.000" "False" "14.210" "4" "5" "5" "5" "1720" "194.7" "7.03" "10.30" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04997, Pf04998, Pf05000" "25885" "ENSG00000068654" "POLR1A" "B7Z7T0; D6W5M0; hsa:25885; O95602; Q0VG05; Q9UEH0; Q9UFT9" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "8" "0" "1.388" "1.229" "1.325" "1.107" "1.247" "1.091" "0.549" "1.118" "8.307" "31.8" "44.1" "39.1" "42.1" "35.2" "39.6" "34.7" "17.4" "35.5" "264.0" "" "" "" "" "" "" "" "" "" "" "19.0" "22.9" "21.6" "19.8" "16.3" "20.3" "16.1" "7.8" "19.3" "264.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5439043522832827691" "False" "High" "IsMasterProtein" "Q8WZA0" "Protein LZIC OS=Homo sapiens OX=9606 GN=LZIC PE=1 SV=1" "0.000" "False" "14.199" "18" "4" "9" "4" "190" "21.5" "4.94" "29.73" "4" "other biological processes" "" "other molecular function" "Pf06384" "84328" "ENSG00000162441" "LZIC" "B2R6F0; B4E2N0; hsa:84328; Q8WZA0; Q96IU1" "" "" "0" "0" "0.980" "1.018" "1.068" "1.157" "1.060" "1.388" "1.303" "1.190" "0.646" "1201.9" "1177.6" "1223.2" "1283.7" "1390.9" "1273.6" "1668.5" "1565.6" "1430.4" "777.0" "" "" "" "" "" "" "" "" "" "" "719.3" "611.9" "677.4" "602.7" "644.7" "652.0" "775.8" "702.9" "776.0" "777.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1917909410339364485" "False" "High" "IsMasterProtein" "Q96QC0" "Serine/threonine-protein phosphatase 1 regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PPP1R10 PE=1 SV=1" "0.000" "False" "14.196" "6" "6" "6" "6" "940" "99.0" "9.17" "11.26" "6" "transport;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00642, Pf08711" "5514" "ENSG00000204569; ENSG00000206489; ENSG00000227804; ENSG00000230995; ENSG00000231737; ENSG00000235291; ENSG00000238104" "PPP1R10" "hsa:5514; O00405; Q96QC0" "" "" "0" "0" "0.949" "0.809" "1.162" "1.026" "1.176" "1.095" "1.069" "1.029" "1.553" "183.9" "174.5" "148.7" "213.8" "188.7" "216.4" "201.3" "196.6" "189.2" "285.5" "" "" "" "" "" "" "" "" "" "" "110.1" "90.7" "82.4" "100.4" "87.5" "110.8" "93.6" "88.3" "102.6" "285.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6205796797264401430" "False" "High" "IsMasterProtein" "Q96DH6" "RNA-binding protein Musashi homolog 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1" "0.000" "False" "14.192" "11" "3" "5" "3" "328" "35.2" "8.48" "10.30" "3" "developmental processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "124540" "ENSG00000153944" "MSI2" "hsa:124540; Q7Z6M7; Q8N9T4; Q96DH6" "" "RHOBTB2 GTPase cycle" "1" "0" "0.972" "1.056" "1.148" "1.294" "1.065" "1.141" "1.117" "1.083" "1.065" "190.3" "184.9" "201.0" "218.5" "246.2" "202.6" "217.2" "212.5" "206.2" "202.7" "" "" "" "" "" "" "" "" "" "" "113.9" "96.1" "111.3" "102.6" "114.1" "103.7" "101.0" "95.4" "111.9" "202.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1319936172901890664" "False" "High" "IsMasterProtein" "P45973" "Chromobox protein homolog 5 OS=Homo sapiens OX=9606 GN=CBX5 PE=1 SV=1" "0.000" "False" "14.189" "23" "4" "4" "4" "191" "22.2" "5.86" "10.29" "4" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00385, Pf01393" "23468" "ENSG00000094916" "CBX5" "B2R8T9; hsa:23468; P45973" "Effect of progerin on genes involved in progeria; 22q11.2 copy number variation syndrome" "SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6; Factors involved in megakaryocyte development and platelet production" "5" "0" "0.974" "1.390" "0.977" "0.946" "0.992" "0.981" "0.997" "1.132" "1.600" "232.5" "226.4" "323.2" "227.3" "220.0" "230.7" "228.2" "232.0" "263.3" "372.0" "" "" "" "" "" "" "" "" "" "" "139.2" "117.7" "179.0" "106.7" "102.0" "118.1" "106.1" "104.1" "142.9" "372.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4235464357787345308" "False" "High" "IsMasterProtein" "Q15370" "Elongin-B OS=Homo sapiens OX=9606 GN=ELOB PE=1 SV=1" "0.000" "False" "14.178" "20" "3" "11" "3" "118" "13.1" "4.88" "28.74" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00240" "6923" "ENSG00000103363" "ELOB" "B7WPD3; hsa:6923; Q15370" "Dual hijack model of Vif in HIV infection; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2; Modulators of TCR signaling and T cell activation" "Inactivation of CSF3 (G-CSF) signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Regulation of expression of SLITs and ROBOs; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Evasion by RSV of host interferon responses" "22" "0" "1.101" "1.058" "1.050" "1.185" "1.106" "1.206" "1.070" "1.051" "1.238" "834.5" "918.9" "882.6" "876.1" "988.6" "922.8" "1006.6" "893.3" "876.8" "1032.8" "" "" "" "" "" "" "" "" "" "" "499.4" "477.5" "488.7" "411.3" "458.3" "472.4" "468.0" "401.0" "475.7" "1032.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4492999109905159377" "False" "High" "IsMasterProtein" "Q15121" "Astrocytic phosphoprotein PEA-15 OS=Homo sapiens OX=9606 GN=PEA15 PE=1 SV=2" "0.000" "False" "14.166" "29" "4" "7" "4" "130" "15.0" "5.02" "16.57" "4" "transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf01335" "8682" "ENSG00000162734" "PEA15" "B1AKZ3; hsa:8682; O00511; Q15121" "Apoptosis modulation and signaling" "RAF/MAP kinase cascade; RAF-independent MAPK1/3 activation" "3" "0" "0.989" "1.102" "0.986" "1.112" "0.963" "1.208" "0.907" "0.987" "1.753" "704.9" "696.8" "776.7" "695.0" "784.0" "679.0" "851.4" "639.2" "695.4" "1235.5" "" "" "" "" "" "" "" "" "" "" "421.8" "362.1" "430.1" "326.3" "363.4" "347.6" "395.9" "287.0" "377.3" "1235.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "978357741075337008" "False" "High" "IsMasterProtein" "Q6UN15" "Pre-mRNA 3'-end-processing factor FIP1 OS=Homo sapiens OX=9606 GN=FIP1L1 PE=1 SV=1" "0.000" "False" "14.151" "9" "4" "6" "4" "594" "66.5" "5.59" "7.79" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf05182" "81608" "ENSG00000145216" "FIP1L1" "B4DIR3; G3XAD6; hsa:81608; Q0VGE0; Q499Y4; Q49AU3; Q6UN15; Q7Z608; Q8WVN3; Q96F80; Q9H077" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA Derived from an Intronless Transcript; Processing of Intronless Pre-mRNAs; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins" "6" "0" "0.991" "1.059" "0.973" "1.025" "0.979" "0.899" "1.120" "1.070" "0.868" "86.0" "85.2" "91.1" "83.7" "88.1" "84.2" "77.3" "96.3" "92.0" "74.7" "" "" "" "" "" "" "" "" "" "" "51.5" "44.3" "50.4" "39.3" "40.9" "43.1" "35.9" "43.2" "49.9" "74.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3157784244312675539" "False" "High" "IsMasterProtein" "Q9UKD2" "mRNA turnover protein 4 homolog OS=Homo sapiens OX=9606 GN=MRTO4 PE=1 SV=2" "0.000" "False" "14.147" "21" "5" "5" "5" "239" "27.5" "8.29" "11.17" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00466, Pf17777" "51154" "ENSG00000053372" "MRTO4" "B3KNB3; hsa:51154; Q5TG55; Q96SS6; Q9BPV9; Q9UKD2" "" "" "0" "0" "0.965" "0.908" "1.041" "0.908" "0.953" "0.854" "0.925" "0.923" "0.898" "211.6" "204.1" "192.1" "220.3" "192.0" "201.6" "180.6" "195.6" "195.3" "190.0" "" "" "" "" "" "" "" "" "" "" "126.6" "106.1" "106.4" "103.4" "89.0" "103.2" "84.0" "87.8" "106.0" "190.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6179525910857735181" "False" "High" "IsMasterProtein" "P49590" "Histidine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=HARS2 PE=1 SV=1" "0.000" "False" "14.146" "7" "4" "8" "1" "506" "56.9" "8.24" "20.58" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf03129, Pf13393" "23438" "ENSG00000112855" "HARS2" "B4DDY8; hsa:23438; P49590" "Primary ovarian insufficiency" "Mitochondrial tRNA aminoacylation" "2" "0" "1.045" "1.058" "1.131" "0.871" "1.111" "0.889" "1.105" "0.935" "0.677" "51.8" "54.2" "54.8" "58.6" "45.1" "57.5" "46.0" "57.2" "48.5" "35.1" "" "" "" "" "" "" "" "" "" "" "31.0" "28.2" "30.4" "27.5" "20.9" "29.5" "21.4" "25.7" "26.3" "35.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5859818642723021868" "False" "High" "IsMasterProtein" "Q96RS6" "NudC domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NUDCD1 PE=1 SV=2" "0.000" "False" "14.116" "7" "5" "8" "5" "583" "66.7" "5.11" "15.78" "5" "other biological processes" "cytosol;nucleus" "" "Pf04969" "84955" "ENSG00000120526" "NUDCD1" "B4DVX6; hsa:84955; Q4G130; Q8NDQ5; Q8NG18; Q96RS6; Q96SI4; Q9BVR5" "" "" "0" "0" "0.988" "1.042" "0.931" "0.933" "1.137" "0.904" "0.992" "0.979" "1.305" "615.1" "607.9" "640.7" "572.8" "574.1" "699.7" "555.8" "610.5" "602.3" "802.5" "" "" "" "" "" "" "" "" "" "" "368.1" "315.9" "354.8" "268.9" "266.1" "358.2" "258.4" "274.1" "326.8" "802.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2904127799800100027" "False" "High" "IsMasterProtein" "Q8IYS1" "Xaa-Arg dipeptidase OS=Homo sapiens OX=9606 GN=PM20D2 PE=1 SV=2" "0.000" "False" "14.097" "8" "4" "6" "4" "436" "47.7" "5.85" "15.28" "4" "protein metabolism;other biological processes" "nucleus" "other molecular function" "Pf01546, Pf07687" "135293" "ENSG00000146281" "PM20D2" "B4DYJ2; hsa:135293; Q5T7J9; Q6MZV2; Q86XD9; Q8IYS1" "" "" "0" "0" "1.180" "1.014" "1.075" "1.123" "0.990" "1.367" "1.095" "1.220" "2.175" "187.8" "221.5" "190.5" "201.9" "210.8" "185.9" "256.7" "205.6" "229.1" "408.4" "" "" "" "" "" "" "" "" "" "" "112.4" "115.1" "105.5" "94.8" "97.7" "95.1" "119.4" "92.3" "124.3" "408.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4465081379876381336" "False" "High" "IsMasterProtein" "Q86U70" "LIM domain-binding protein 1 OS=Homo sapiens OX=9606 GN=LDB1 PE=1 SV=2" "0.000" "False" "14.036" "11" "4" "5" "4" "411" "46.5" "6.96" "10.70" "4" "cell adhesion;cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01803, Pf17916" "8861" "ENSG00000198728" "LDB1" "B4DUC4; hsa:8861; O75479; O96010; Q1EQX1; Q86U70; Q9UGM4" "" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of expression of SLITs and ROBOs; Expression and translocation of olfactory receptors; Cardiogenesis" "4" "0" "1.104" "1.022" "1.087" "1.043" "1.088" "0.951" "1.105" "1.095" "0.849" "95.4" "105.3" "97.5" "103.7" "99.5" "103.8" "90.8" "105.4" "104.5" "81.0" "" "" "" "" "" "" "" "" "" "" "57.1" "54.7" "54.0" "48.7" "46.1" "53.1" "42.2" "47.3" "56.7" "81.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-630716066930521994" "False" "High" "IsMasterProtein" "P55957" "BH3-interacting domain death agonist OS=Homo sapiens OX=9606 GN=BID PE=1 SV=1" "0.000" "False" "14.030" "12" "2" "5" "2" "195" "22.0" "5.44" "12.45" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf06393" "637" "ENSG00000015475" "BID" "hsa:637; P55957; Q549M7; Q71T04; Q7Z4M9; Q8IY86" "miRNA regulation of DNA damage response; TP53 network; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Apoptosis modulation by HSP70; Regulation of apoptosis by parathyroid hormone-related protein; miRNA regulation of p53 pathway in prostate cancer; Non-small cell lung cancer; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Unfolded protein response; Complement system in neuronal development and plasticity; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; DNA damage response" "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Activation, myristolyation of BID and translocation to mitochondria; Activation of BAD and translocation to mitochondria ; Activation and oligomerization of BAK protein; Activation, translocation and oligomerization of BAX" "30" "0" "1.047" "0.866" "1.045" "1.363" "1.009" "1.093" "1.226" "1.072" "0.549" "154.7" "162.0" "133.9" "161.6" "210.8" "156.1" "169.0" "189.6" "165.8" "85.0" "" "" "" "" "" "" "" "" "" "" "92.6" "84.2" "74.1" "75.9" "97.7" "79.9" "78.6" "85.1" "89.9" "85.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2337830748365545884" "False" "High" "IsMasterProtein" "Q53FT3" "Protein Hikeshi OS=Homo sapiens OX=9606 GN=HIKESHI PE=1 SV=2" "0.000" "False" "14.006" "10" "2" "3" "2" "197" "21.6" "5.45" "11.31" "2" "cell organization and biogenesis;stress response;transport;developmental processes" "cytosol;nucleus" "other molecular function" "Pf05603, Pf21057" "51501" "ENSG00000149196" "HIKESHI" "hsa:51501; Q53FT3; Q8WVE8; Q9NVQ2; Q9NZZ1; Q9P022; Q9P0N1" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "1.091" "1.035" "1.035" "1.141" "1.109" "0.928" "1.192" "1.088" "1.152" "300.7" "328.0" "311.2" "311.1" "343.2" "333.4" "278.9" "358.5" "327.3" "346.4" "" "" "" "" "" "" "" "" "" "" "179.9" "170.5" "172.3" "146.1" "159.1" "170.7" "129.7" "160.9" "177.6" "346.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7131720843867798084" "False" "High" "IsMasterProtein" "Q9BT09" "Protein canopy homolog 3 OS=Homo sapiens OX=9606 GN=CNPY3 PE=1 SV=1" "0.000" "False" "13.979" "14" "3" "6" "3" "278" "30.7" "5.49" "17.64" "3" "stress response" "ER/Golgi" "signal transduction activity or receptor binding" "Pf11938" "10695" "ENSG00000137161" "CNPY3" "hsa:10695; O15412; Q0P6I2; Q8NF54; Q8WTU8; Q9BT09; Q9P0F2" "" "Trafficking and processing of endosomal TLR" "1" "0" "1.021" "0.990" "0.945" "1.162" "1.051" "1.009" "1.118" "1.028" "0.530" "681.9" "696.2" "674.8" "644.5" "792.4" "716.4" "688.0" "762.7" "701.0" "361.5" "" "" "" "" "" "" "" "" "" "" "408.1" "361.8" "373.7" "302.6" "367.3" "366.7" "319.9" "342.4" "380.3" "361.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8722067118007621165" "False" "High" "IsMasterProtein" "P23497" "Nuclear autoantigen Sp-100 OS=Homo sapiens OX=9606 GN=SP100 PE=1 SV=3" "0.000" "False" "13.977" "5" "3" "4" "2" "879" "100.4" "8.22" "12.60" "3" "cell organization and biogenesis;DNA metabolism;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf01342, Pf03172, Pf09011" "6672" "ENSG00000067066" "SP100" "B4DDX5; B8ZZD8; E7EUA7; E9PH61; F8WFE2; hsa:6672; O75450; P23497; Q13343; Q8TE34; Q96F70; Q96T24; Q96T95; Q9NP33; Q9UE32" "" "SUMOylation of DNA damage response and repair proteins; Interferon gamma signaling" "2" "0" "1.357" "1.114" "1.032" "1.188" "1.188" "1.264" "1.462" "1.264" "0.894" "44.0" "59.8" "49.1" "45.5" "52.3" "52.3" "55.7" "64.4" "55.7" "39.4" "" "" "" "" "" "" "" "" "" "" "26.4" "31.1" "27.2" "21.3" "24.3" "26.8" "25.9" "28.9" "30.2" "39.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1270194887050037302" "False" "High" "IsMasterProtein" "Q9UBW8" "COP9 signalosome complex subunit 7a OS=Homo sapiens OX=9606 GN=COPS7A PE=1 SV=1" "0.000" "False" "13.966" "19" "4" "4" "4" "275" "30.3" "8.22" "9.85" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf18392" "50813" "ENSG00000111652" "COPS7A" "A8K9A6; hsa:50813; Q9NVX3; Q9UBW8; Q9UJW4" "Ciliary landscape" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER" "5" "0" "1.022" "0.875" "0.939" "0.981" "0.978" "0.965" "0.896" "1.028" "0.823" "146.3" "149.5" "128.0" "137.4" "143.5" "143.2" "141.2" "131.2" "150.4" "120.5" "" "" "" "" "" "" "" "" "" "" "87.6" "77.7" "70.9" "64.5" "66.5" "73.3" "65.6" "58.9" "81.6" "120.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-693009755778798309" "False" "High" "IsMasterProtein" "O75396" "Vesicle-trafficking protein SEC22b OS=Homo sapiens OX=9606 GN=SEC22B PE=1 SV=5" "0.000" "False" "13.927" "19" "3" "4" "3" "215" "24.7" "8.51" "12.55" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00957, Pf13774" "9554" "ENSG00000265808" "SEC22B" "A8K1G0; hsa:9554; O75396" "" "COPI-dependent Golgi-to-ER retrograde traffic; ER-Phagosome pathway; COPII-mediated vesicle transport; Cargo concentration in the ER" "4" "0" "1.131" "0.969" "1.034" "1.180" "1.098" "1.099" "1.058" "1.111" "1.006" "146.3" "165.5" "141.7" "151.3" "172.6" "160.6" "160.8" "154.8" "162.5" "147.1" "" "" "" "" "" "" "" "" "" "" "87.6" "86.0" "78.5" "71.0" "80.0" "82.2" "74.7" "69.5" "88.1" "147.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9158883592383283846" "False" "High" "IsMasterProtein" "P60983" "Glia maturation factor beta OS=Homo sapiens OX=9606 GN=GMFB PE=1 SV=2" "0.000" "False" "13.918" "14" "2" "9" "2" "142" "16.7" "5.29" "30.19" "2" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241" "2764" "ENSG00000197045" "GMFB" "B2R499; hsa:2764; P17774; P60983; Q9BS35" "" "" "0" "0" "1.029" "0.963" "1.007" "1.018" "0.970" "0.974" "1.047" "0.994" "0.620" "928.6" "955.7" "893.8" "935.2" "945.2" "901.2" "904.5" "972.3" "923.4" "576.0" "" "" "" "" "" "" "" "" "" "" "555.7" "496.6" "495.0" "439.1" "438.1" "461.3" "420.6" "436.5" "501.0" "576.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2830448209821531490" "False" "High" "IsMasterProtein" "Q9GZS3" "Superkiller complex protein 8 OS=Homo sapiens OX=9606 GN=SKIC8 PE=1 SV=1" "0.000" "False" "13.909" "11" "3" "7" "3" "305" "33.6" "5.47" "17.27" "3" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "80349" "ENSG00000140395" "SKIC8" "D3DW84; hsa:80349; Q6IA22; Q7Z4X4; Q9GZS3" "" "E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; mRNA decay by 3' to 5' exoribonuclease" "5" "0" "0.965" "1.041" "1.018" "1.081" "1.115" "0.944" "0.929" "0.966" "1.079" "234.2" "226.1" "243.8" "238.4" "253.1" "261.2" "221.1" "217.7" "226.2" "252.7" "" "" "" "" "" "" "" "" "" "" "140.2" "117.5" "135.0" "111.9" "117.3" "133.7" "102.8" "97.7" "122.7" "252.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1681644365065118187" "False" "High" "IsMasterProtein" "Q8IVS2" "Malonyl-CoA-acyl carrier protein transacylase, mitochondrial OS=Homo sapiens OX=9606 GN=MCAT PE=1 SV=2" "0.000" "False" "13.880" "13" "5" "9" "5" "390" "42.9" "8.72" "16.41" "5" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00698" "27349" "ENSG00000100294" "MCAT" "B0QY72; O95510; O95511; Q8IVS2" "Mitochondrial fatty acid synthesis pathway" "Mitochondrial Fatty Acid Beta-Oxidation" "2" "0" "0.945" "1.076" "1.107" "1.152" "1.238" "1.086" "1.110" "1.015" "1.075" "230.9" "218.1" "248.5" "255.7" "266.1" "285.9" "250.8" "256.2" "234.3" "248.1" "" "" "" "" "" "" "" "" "" "" "138.2" "113.3" "137.6" "120.0" "123.3" "146.4" "116.6" "115.0" "127.1" "248.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5032092853006601019" "False" "High" "IsMasterProtein" "Q13303" "Voltage-gated potassium channel subunit beta-2 OS=Homo sapiens OX=9606 GN=KCNAB2 PE=1 SV=2" "0.000" "False" "13.859" "7" "3" "9" "3" "367" "41.0" "9.00" "26.44" "3" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "transporter activity;other molecular function" "Pf00248" "8514" "ENSG00000069424" "KCNAB2" "A0AVM9; A8K1A4; B0AZR7; hsa:8514; O43659; Q13303; Q2YD85; Q5TG82; Q5TG83; Q6ZNE4; Q99411" "Metapathway biotransformation Phase I and II" "Neutrophil degranulation; Voltage gated Potassium channels" "3" "0" "0.922" "1.056" "0.997" "1.014" "0.998" "0.984" "0.979" "1.070" "0.652" "436.7" "402.7" "461.3" "435.2" "442.6" "435.6" "429.7" "427.7" "467.5" "284.8" "" "" "" "" "" "" "" "" "" "" "261.3" "209.2" "255.5" "204.3" "205.2" "223.0" "199.8" "192.0" "253.6" "284.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6811152372553307115" "False" "High" "IsMasterProtein" "Q9Y2X3" "Nucleolar protein 58 OS=Homo sapiens OX=9606 GN=NOP58 PE=1 SV=1" "0.000" "False" "13.850" "7" "4" "6" "4" "529" "59.5" "8.92" "12.19" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01798, Pf08156" "51602" "ENSG00000055044" "NOP58" "hsa:51602; Q53SA4; Q6PK08; Q9P036; Q9UFN3; Q9Y2X3" "" "Major pathway of rRNA processing in the nucleolus and cytosol; SUMOylation of RNA binding proteins; rRNA modification in the nucleus and cytosol" "3" "0" "1.107" "0.768" "0.795" "1.115" "1.012" "0.827" "0.893" "0.860" "0.984" "65.5" "72.5" "50.3" "52.0" "73.0" "66.3" "54.2" "58.4" "56.3" "64.5" "" "" "" "" "" "" "" "" "" "" "39.2" "37.7" "27.8" "24.4" "33.8" "33.9" "25.2" "26.2" "30.6" "64.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3818907558764607522" "False" "High" "IsMasterProtein" "Q8IWD4" "Coiled-coil domain-containing protein 117 OS=Homo sapiens OX=9606 GN=CCDC117 PE=1 SV=1" "0.000" "False" "13.825" "16" "4" "5" "4" "279" "30.5" "5.07" "12.31" "4" "other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf15810" "150275" "ENSG00000159873" "CCDC117" "A8K0F1; B7Z2V1; B7Z860; hsa:150275; Q6ICA7; Q8IWD4; Q8N278" "" "" "0" "0" "1.052" "1.049" "1.027" "1.058" "0.915" "1.051" "1.131" "0.998" "0.822" "124.7" "131.2" "130.8" "128.0" "131.9" "114.1" "131.1" "141.0" "124.5" "102.5" "" "" "" "" "" "" "" "" "" "" "74.6" "68.2" "72.5" "60.1" "61.2" "58.4" "61.0" "63.3" "67.5" "102.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8894400129343683729" "False" "High" "IsMasterProtein" "Q9BUH6" "Protein PAXX OS=Homo sapiens OX=9606 GN=PAXX PE=1 SV=2" "0.000" "False" "13.817" "17" "3" "5" "3" "204" "21.6" "5.48" "9.40" "3" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf15384" "286257" "ENSG00000148362" "PAXX" "hsa:286257; Q8IY19; Q9BUH6" "" "" "0" "0" "1.075" "1.012" "1.044" "1.098" "1.120" "1.067" "1.072" "0.925" "0.767" "116.0" "124.7" "117.4" "121.1" "127.3" "130.0" "123.8" "124.3" "107.3" "89.0" "" "" "" "" "" "" "" "" "" "" "69.4" "64.8" "65.0" "56.9" "59.0" "66.5" "57.5" "55.8" "58.2" "89.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2665594491149638353" "False" "High" "IsMasterProtein" "P12931" "Proto-oncogene tyrosine-protein kinase Src OS=Homo sapiens OX=9606 GN=SRC PE=1 SV=3" "0.000" "False" "13.809" "7" "4" "4" "4" "536" "59.8" "7.42" "12.05" "4" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "6714" "ENSG00000197122; ENSG00000291971" "SRC" "E1P5V4; hsa:6714; P12931; Q76P87; Q86VB9; Q9H5A8" "Androgen receptor signaling pathway; Angiogenesis; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; AGE/RAGE pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Polycystic kidney disease pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; IL-3 signaling pathway; Aryl hydrocarbon receptor pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; TGF-beta signaling pathway; Amplification and expansion of oncogenic pathways as metastatic traits; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Robo4 and VEGF signaling pathways crosstalk; Fibrin complement receptor 3 signaling pathway; MET in type 1 papillary renal cell carcinoma; Acute viral myocarditis; NRF2-ARE regulation; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; EGFR tyrosine kinase inhibitor resistance; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; 5q35 copy number variation; EPO receptor signaling; Notch signaling pathway; ErbB signaling pathway" "G alpha (i) signalling events; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; PIP3 activates AKT signaling; Signaling by BRAF and RAF1 fusions; Regulation of RUNX3 expression and activity; RHOU GTPase cycle; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; DCC mediated attractive signaling; Downstream signal transduction; Signaling by ERBB2; Nuclear signaling by ERBB4; RAF activation; GAB1 signalosome; MET activates PTK2 signaling; Signaling by CSF1 (M-CSF) in myeloid cells; RUNX2 regulates osteoblast differentiation; Long-term potentiation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; InlA-mediated entry of Listeria monocytogenes into host cells; Regulation of commissural axon pathfinding by SLIT and ROBO; Netrin mediated repulsion signals; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Activated NTRK2 signals through FYN; Downregulation of ERBB4 signaling; Regulation of RUNX1 Expression and Activity; Activated NTRK3 signals through PI3K" "90" "0" "1.202" "1.152" "0.824" "0.901" "1.030" "0.923" "0.854" "1.180" "1.771" "64.2" "77.2" "73.9" "52.9" "57.8" "66.1" "59.2" "54.8" "75.7" "113.6" "" "" "" "" "" "" "" "" "" "" "38.4" "40.1" "40.9" "24.8" "26.8" "33.8" "27.5" "24.6" "41.1" "113.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2101401554741180333" "False" "High" "IsMasterProtein" "Q8N5M1" "ATP synthase mitochondrial F1 complex assembly factor 2 OS=Homo sapiens OX=9606 GN=ATPAF2 PE=1 SV=1" "0.000" "False" "13.781" "8" "2" "4" "2" "289" "32.8" "7.09" "15.07" "2" "cell organization and biogenesis" "cytosol;mitochondrion;nucleus" "" "Pf07542" "91647" "ENSG00000171953" "ATPAF2" "A6NDE5; A8K2J2; hsa:91647; Q6XYC7; Q8N5M1" "7q11.23 copy number variation syndrome; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "" "2" "0" "0.894" "0.897" "0.936" "1.027" "0.990" "0.948" "1.003" "0.933" "0.761" "357.1" "319.1" "320.2" "334.4" "366.7" "353.4" "338.5" "358.3" "333.2" "271.7" "" "" "" "" "" "" "" "" "" "" "213.7" "165.8" "177.3" "157.0" "170.0" "180.9" "157.4" "160.9" "180.8" "271.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3818146926309850822" "False" "High" "IsMasterProtein" "O95671" "Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein OS=Homo sapiens OX=9606 GN=ASMTL PE=1 SV=3" "0.000" "False" "13.773" "9" "4" "4" "4" "621" "68.8" "6.07" "8.78" "4" "other metabolic processes" "cytosol" "other molecular function" "Pf00891, Pf02545, Pf16864" "8623" "ENSG00000169093; ENSG00000292339" "ASMTL" "B4DX75; F5GXH4; hsa:8623; J3JS33; O95671; Q5JQ53; Q8NBH5; Q96G02; Q9BUL6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4643868144451564503" "False" "High" "IsMasterProtein" "P41567" "Eukaryotic translation initiation factor 1 OS=Homo sapiens OX=9606 GN=EIF1 PE=1 SV=1" "0.000" "False" "13.762" "27" "2" "6" "2" "113" "12.7" "7.44" "17.43" "2" "protein metabolism;other metabolic processes;other biological processes" "translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01253" "10209" "ENSG00000173812" "EIF1" "hsa:10209; P41567; Q9UNQ9" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "" "2" "0" "1.062" "1.151" "1.129" "1.221" "1.346" "1.298" "1.385" "1.172" "0.748" "153.0" "162.5" "176.1" "172.8" "186.7" "205.9" "198.6" "211.9" "179.4" "114.5" "" "" "" "" "" "" "" "" "" "" "91.6" "84.5" "97.5" "81.1" "86.6" "105.4" "92.4" "95.1" "97.3" "114.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4838568104168178339" "False" "High" "IsMasterProtein" "Q8TBC4" "NEDD8-activating enzyme E1 catalytic subunit OS=Homo sapiens OX=9606 GN=UBA3 PE=1 SV=2" "0.000" "False" "13.759" "10" "5" "5" "5" "463" "51.8" "5.45" "13.47" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00899, Pf08825" "9039" "ENSG00000144744" "UBA3" "A6NLB5; A8K027; hsa:9039; O76088; Q8TBC4; Q9NTU3" "Hijack of ubiquitination by SARS-CoV-2" "Antigen processing: Ubiquitination & Proteasome degradation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Neddylation" "5" "0" "0.893" "1.040" "0.985" "0.966" "1.058" "1.102" "0.844" "1.158" "3.838" "142.5" "127.4" "148.2" "140.4" "137.8" "150.8" "157.0" "120.3" "165.1" "547.0" "" "" "" "" "" "" "" "" "" "" "85.3" "66.2" "82.1" "65.9" "63.9" "77.2" "73.0" "54.0" "89.6" "547.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1949176893953303809" "False" "High" "IsMasterProtein" "Q9NZZ3" "Charged multivesicular body protein 5 OS=Homo sapiens OX=9606 GN=CHMP5 PE=1 SV=1" "0.000" "False" "13.750" "18" "3" "4" "3" "219" "24.6" "4.83" "9.26" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf03357" "51510" "ENSG00000086065" "CHMP5" "B2RD95; B4DIR6; hsa:51510; Q5VXW2; Q96AV2; Q9HB68; Q9NYS4; Q9NZZ3; Q9Y323" "Ferroptosis" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "3" "0" "0.935" "0.916" "0.876" "0.945" "0.836" "1.085" "1.059" "0.924" "0.426" "386.7" "361.5" "354.0" "338.6" "365.3" "323.4" "419.5" "409.6" "357.3" "164.8" "" "" "" "" "" "" "" "" "" "" "231.4" "187.8" "196.1" "159.0" "169.3" "165.6" "195.1" "183.9" "193.8" "164.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3959098677357932626" "False" "High" "IsMasterProtein" "O43747" "AP-1 complex subunit gamma-1 OS=Homo sapiens OX=9606 GN=AP1G1 PE=1 SV=5" "0.000" "False" "13.728" "5" "5" "5" "4" "822" "91.3" "6.80" "10.15" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf01602, Pf02883" "164" "ENSG00000166747" "AP1G1" "hsa:164; O43747; O75709; O75842; Q9UG09; Q9Y3U4" "" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "4" "0" "0.905" "0.887" "1.105" "0.978" "0.879" "1.021" "0.686" "1.092" "5.485" "90.8" "82.2" "80.5" "100.4" "88.9" "79.8" "92.7" "62.3" "99.2" "498.2" "" "" "" "" "" "" "" "" "" "" "54.4" "42.7" "44.6" "47.1" "41.2" "40.9" "43.1" "28.0" "53.8" "498.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3196663768808374141" "False" "High" "IsMasterProtein" "Q9UBP6" "tRNA (guanine-N(7)-)-methyltransferase OS=Homo sapiens OX=9606 GN=METTL1 PE=1 SV=1" "0.000" "False" "13.718" "15" "4" "9" "4" "276" "31.5" "7.64" "10.45" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02390" "4234" "ENSG00000037897" "METTL1" "B2RBX1; H7BXF2; hsa:4234; Q14105; Q53FS9; Q9UBP6" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.998" "0.972" "1.045" "0.948" "1.002" "0.989" "1.048" "1.051" "0.656" "357.0" "356.2" "347.1" "373.1" "338.6" "357.6" "353.2" "374.1" "375.1" "234.1" "" "" "" "" "" "" "" "" "" "" "213.6" "185.1" "192.2" "175.2" "156.9" "183.0" "164.2" "168.0" "203.5" "234.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7804593392060362224" "False" "High" "IsMasterProtein" "P14324" "Farnesyl pyrophosphate synthase OS=Homo sapiens OX=9606 GN=FDPS PE=1 SV=4" "0.000" "False" "13.715" "9" "3" "7" "3" "419" "48.2" "6.15" "19.60" "3" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00348" "2224" "ENSG00000160752" "FDPS" "D3DV91; E9PCI9; hsa:2224; P14324; Q96G29" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "9" "0" "0.980" "1.055" "1.036" "0.992" "1.061" "1.261" "0.589" "1.115" "8.994" "87.9" "86.1" "92.7" "91.0" "87.2" "93.2" "110.8" "51.8" "98.0" "790.2" "" "" "" "" "" "" "" "" "" "" "52.6" "44.7" "51.3" "42.7" "40.4" "47.7" "51.5" "23.2" "53.1" "790.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2825408205880823904" "False" "High" "IsMasterProtein" "P14635" "G2/mitotic-specific cyclin-B1 OS=Homo sapiens OX=9606 GN=CCNB1 PE=1 SV=1" "0.000" "False" "13.707" "9" "4" "5" "4" "433" "48.3" "7.47" "16.81" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00134, Pf02984" "891" "ENSG00000134057" "CCNB1" "A8K066; hsa:891; P14635; Q5TZP9" "AMP-activated protein kinase signaling; miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATM signaling pathway; G1 to S cell cycle control; GDNF signaling; IL-19 signaling pathway; DNA damage response" "The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of the APC/C; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Cyclin A/B1/B2 associated events during G2/M transition; Transcriptional regulation by RUNX2; MASTL Facilitates Mitotic Progression; E2F-enabled inhibition of pre-replication complex formation; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; Initiation of Nuclear Envelope (NE) Reformation; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Depolymerization of the Nuclear Lamina; Nuclear events stimulated by ALK signaling in cancer; Phosphorylation of Emi1" "33" "0" "0.882" "0.827" "0.958" "0.995" "0.936" "1.100" "1.080" "1.065" "0.833" "784.0" "691.5" "648.4" "751.4" "780.3" "734.1" "862.7" "846.9" "835.1" "653.1" "" "" "" "" "" "" "" "" "" "" "469.2" "359.4" "359.1" "352.8" "361.7" "375.8" "401.1" "380.2" "453.1" "653.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3970061411929191167" "False" "High" "IsMasterProtein" "Q96G61" "Diphosphoinositol polyphosphate phosphohydrolase 3-beta OS=Homo sapiens OX=9606 GN=NUDT11 PE=1 SV=1" "0.000" "False" "13.706" "23" "4" "6" "2" "164" "18.5" "5.99" "10.37" "4" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00293" "55190" "ENSG00000196368" "NUDT11" "hsa:55190; Q96G61; Q9NVN0" "" "Synthesis of pyrophosphates in the cytosol" "1" "2" "1.050" "1.028" "0.905" "0.946" "1.025" "1.009" "0.882" "1.063" "2.072" "252.7" "265.3" "259.9" "228.7" "239.1" "259.1" "254.9" "222.8" "268.6" "523.6" "" "" "" "" "" "" "" "" "" "" "151.2" "137.9" "143.9" "107.3" "110.8" "132.6" "118.5" "100.0" "145.8" "523.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8528417393103392868" "False" "High" "IsMasterProtein" "Q9BQ04" "RNA-binding protein 4B OS=Homo sapiens OX=9606 GN=RBM4B PE=1 SV=1" "0.000" "False" "13.695" "13" "5" "5" "5" "359" "40.1" "6.74" "12.32" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00076, Pf00098" "83759" "ENSG00000173914" "RBM4B" "B3KT83; hsa:83759; Q9BQ04" "" "" "0" "0" "1.362" "1.638" "1.289" "1.758" "1.656" "1.467" "1.542" "1.628" "5.798" "24.9" "33.9" "40.7" "32.0" "43.7" "41.2" "36.5" "38.3" "40.5" "144.1" "" "" "" "" "" "" "" "" "" "" "14.9" "17.6" "22.5" "15.0" "20.3" "21.1" "17.0" "17.2" "22.0" "144.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-445851658510322323" "False" "High" "IsMasterProtein" "P55769" "NHP2-like protein 1 OS=Homo sapiens OX=9606 GN=SNU13 PE=1 SV=3" "0.000" "False" "13.691" "27" "3" "9" "3" "128" "14.2" "8.46" "20.02" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01248" "4809" "ENSG00000100138" "SNU13" "hsa:4809; P55769" "mRNA processing" "mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "4" "0" "1.186" "1.114" "1.188" "1.211" "1.082" "1.245" "1.244" "1.230" "0.779" "374.9" "444.8" "417.7" "445.5" "454.1" "405.8" "466.7" "466.4" "461.4" "291.9" "" "" "" "" "" "" "" "" "" "" "224.4" "231.2" "231.3" "209.1" "210.5" "207.7" "217.0" "209.4" "250.3" "291.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7866416472238112790" "False" "High" "IsMasterProtein" "Q14061" "Cytochrome c oxidase copper chaperone OS=Homo sapiens OX=9606 GN=COX17 PE=1 SV=2" "0.000" "False" "13.673" "32" "2" "7" "2" "63" "6.9" "7.24" "24.66" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf05051" "10063" "ENSG00000138495" "COX17" "B2R5D2; D3DN84; hsa:10063; Q14061; Q3MHD6" "Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis; IL-18 signaling pathway; Mitochondrial complex IV assembly" "Mitochondrial protein import" "5" "0" "1.102" "1.084" "1.085" "1.033" "1.134" "0.963" "1.215" "0.977" "0.570" "370.7" "408.6" "401.7" "402.1" "382.9" "420.5" "357.0" "450.5" "362.0" "211.4" "" "" "" "" "" "" "" "" "" "" "221.8" "212.4" "222.4" "188.8" "177.5" "215.3" "166.0" "202.3" "196.4" "211.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8194850060938304098" "False" "High" "IsMasterProtein" "Q8N5I9" "NOP protein chaperone 1 OS=Homo sapiens OX=9606 GN=NOPCHAP1 PE=1 SV=2" "0.000" "False" "13.664" "21" "4" "4" "4" "185" "20.1" "5.22" "12.92" "4" "cell organization and biogenesis" "nucleus" "other molecular function" "Pf15370" "121053" "ENSG00000151131" "NOPCHAP1" "Q8N5I9" "" "" "0" "0" "0.943" "0.897" "0.901" "1.053" "0.950" "1.004" "0.972" "0.892" "0.635" "299.0" "282.1" "268.1" "269.5" "314.9" "284.0" "300.2" "290.8" "266.6" "190.0" "" "" "" "" "" "" "" "" "" "" "178.9" "146.6" "148.5" "126.5" "146.0" "145.4" "139.6" "130.5" "144.7" "190.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8697682766688933342" "False" "High" "IsMasterProtein" "Q9GZZ1" "N-alpha-acetyltransferase 50 OS=Homo sapiens OX=9606 GN=NAA50 PE=1 SV=1" "0.000" "False" "13.634" "22" "4" "7" "4" "169" "19.4" "8.81" "15.18" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "80218" "ENSG00000121579" "NAA50" "D3DN74; hsa:80218; Q68DQ1; Q9GZZ1" "Metapathway biotransformation Phase I and II" "" "1" "0" "0.939" "0.881" "1.031" "0.969" "1.057" "1.058" "1.061" "0.987" "0.743" "357.3" "335.4" "314.8" "368.5" "346.2" "377.5" "378.2" "379.3" "352.8" "265.5" "" "" "" "" "" "" "" "" "" "" "213.8" "174.3" "174.3" "173.0" "160.5" "193.3" "175.8" "170.3" "191.4" "265.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4706681870966743539" "False" "High" "IsMasterProtein" "Q9BWU0" "Kanadaptin OS=Homo sapiens OX=9606 GN=SLC4A1AP PE=1 SV=2" "0.000" "False" "13.611" "5" "3" "4" "3" "742" "82.8" "5.10" "10.33" "3" "" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf00035, Pf00498" "22950" "ENSG00000163798" "SLC4A1AP" "A0A087X0M4; A6NJ39; hsa:22950; Q4KMT1; Q4KMX0; Q7Z5Q9; Q9BWU0; Q9NVN2" "" "" "0" "0" "1.227" "1.309" "0.885" "1.257" "0.947" "0.917" "0.864" "1.090" "2.489" "58.8" "72.1" "76.9" "52.0" "73.9" "55.7" "53.9" "50.8" "64.1" "146.3" "" "" "" "" "" "" "" "" "" "" "35.2" "37.5" "42.6" "24.4" "34.2" "28.5" "25.1" "22.8" "34.8" "146.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6980948205033410350" "False" "High" "IsMasterProtein" "Q8WXI9" "Transcriptional repressor p66-beta OS=Homo sapiens OX=9606 GN=GATAD2B PE=1 SV=1" "0.000" "False" "13.609" "4" "2" "3" "1" "593" "65.2" "9.70" "9.87" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00320, Pf16563" "57459" "ENSG00000143614; ENSG00000261992" "GATAD2B" "D3DUZ2; hsa:57459; Q5VUR2; Q7LG68; Q8WXI9; Q9ULS0" "" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "6" "0" "0.929" "1.231" "1.336" "1.077" "1.098" "1.118" "1.062" "1.472" "4.702" "21.7" "20.1" "26.7" "28.9" "23.3" "23.8" "24.2" "23.0" "31.9" "101.9" "" "" "" "" "" "" "" "" "" "" "13.0" "10.5" "14.8" "13.6" "10.8" "12.2" "11.3" "10.3" "17.3" "101.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2946380844768102927" "False" "High" "IsMasterProtein" "Q96I24" "Far upstream element-binding protein 3 OS=Homo sapiens OX=9606 GN=FUBP3 PE=1 SV=2" "0.000" "False" "13.602" "5" "4" "11" "1" "572" "61.6" "8.38" "28.82" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf00013" "8939" "ENSG00000107164" "FUBP3" "A3KFK8; A3KFL0; hsa:8939; Q92946; Q96I24; Q9BVB6" "" "" "0" "0" "1.007" "1.062" "1.080" "1.080" "1.042" "1.014" "0.984" "1.321" "2.062" "31.1" "31.3" "33.0" "33.6" "33.5" "32.4" "31.5" "30.6" "41.0" "64.1" "" "" "" "" "" "" "" "" "" "" "18.6" "16.3" "18.3" "15.8" "15.5" "16.6" "14.6" "13.7" "22.3" "64.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2548334964560567831" "False" "High" "IsMasterProtein" "Q9GZT8" "NIF3-like protein 1 OS=Homo sapiens OX=9606 GN=NIF3L1 PE=1 SV=2" "0.000" "False" "13.586" "14" "6" "10" "6" "377" "41.9" "6.65" "23.10" "6" "developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf01784" "60491" "ENSG00000196290" "NIF3L1" "hsa:60491; Q53TX4; Q6X735; Q9GZT8; Q9H2D2; Q9HC18" "" "" "0" "0" "0.987" "0.981" "1.047" "1.008" "1.115" "0.901" "0.958" "1.033" "0.863" "421.4" "416.0" "413.3" "441.2" "424.6" "469.7" "379.8" "403.7" "435.4" "363.4" "" "" "" "" "" "" "" "" "" "" "252.2" "216.2" "228.9" "207.2" "196.8" "240.5" "176.6" "181.2" "236.2" "363.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "353320057128082956" "False" "High" "IsMasterProtein" "Q13242" "Serine/arginine-rich splicing factor 9 OS=Homo sapiens OX=9606 GN=SRSF9 PE=1 SV=1" "0.000" "False" "13.580" "14" "3" "5" "3" "221" "25.5" "8.65" "9.65" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "8683" "ENSG00000111786" "SRSF9" "hsa:8683; Q13242; Q52LD1" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "6" "0" "1.124" "1.046" "1.077" "1.272" "1.134" "1.250" "1.300" "1.332" "0.810" "81.1" "91.2" "84.8" "87.4" "103.2" "92.1" "101.5" "105.5" "108.1" "65.8" "" "" "" "" "" "" "" "" "" "" "48.6" "47.4" "47.0" "41.0" "47.9" "47.1" "47.2" "47.4" "58.7" "65.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "105236357953779316" "False" "High" "IsMasterProtein" "Q9H0R4" "Haloacid dehalogenase-like hydrolase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=HDHD2 PE=1 SV=1" "0.000" "False" "13.579" "15" "4" "17" "4" "259" "28.5" "6.24" "45.38" "4" "other metabolic processes" "" "other molecular function" "Pf13242, Pf13344" "84064" "ENSG00000167220" "HDHD2" "A8K7T3; hsa:84064; Q96NV4; Q9H0R4" "" "" "0" "0" "0.992" "0.993" "1.096" "0.896" "1.063" "0.994" "1.119" "1.029" "0.527" "1215.0" "1205.6" "1206.8" "1331.8" "1088.6" "1292.0" "1208.1" "1359.7" "1249.8" "640.7" "" "" "" "" "" "" "" "" "" "" "727.1" "626.5" "668.3" "625.2" "504.6" "661.4" "561.7" "610.4" "678.1" "640.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3936479494832144237" "False" "High" "IsMasterProtein" "Q8TCS8" "Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PNPT1 PE=1 SV=2" "0.000" "False" "13.537" "7" "5" "6" "5" "783" "85.9" "7.77" "10.28" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00575, Pf01138, Pf03725, Pf03726" "87178" "ENSG00000138035" "PNPT1" "hsa:87178; Q53SU0; Q68CN1; Q7Z7D1; Q8IWX1; Q8TCS8; Q96T05; Q9BRU3; Q9BVX0" "Pyrimidine metabolism; miRNA degrading enzymes" "Mitochondrial RNA degradation" "3" "0" "1.170" "1.134" "1.370" "1.506" "1.135" "0.989" "0.771" "1.210" "6.013" "30.4" "35.5" "34.4" "41.6" "45.7" "34.5" "30.0" "23.4" "36.7" "182.6" "" "" "" "" "" "" "" "" "" "" "18.2" "18.5" "19.1" "19.5" "21.2" "17.6" "14.0" "10.5" "19.9" "182.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3508649530452010436" "False" "High" "IsMasterProtein" "P00167" "Cytochrome b5 OS=Homo sapiens OX=9606 GN=CYB5A PE=1 SV=2" "0.000" "False" "13.535" "25" "2" "2" "2" "134" "15.3" "4.96" "8.45" "2" "transport" "other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf00173" "1528" "ENSG00000166347" "CYB5A" "A8MV91; F8WEU4; hsa:1528; P00167; Q6IB14" "Oxidation by cytochrome P450" "Vitamin C (ascorbate) metabolism" "2" "0" "0.899" "0.958" "1.012" "1.246" "1.105" "1.030" "1.104" "1.221" "0.657" "89.3" "80.3" "85.5" "90.4" "111.3" "98.7" "92.0" "98.6" "109.1" "58.7" "" "" "" "" "" "" "" "" "" "" "53.5" "41.7" "47.4" "42.4" "51.6" "50.5" "42.8" "44.3" "59.2" "58.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3054532643706144768" "False" "High" "IsMasterProtein" "Q9H0W9" "Ester hydrolase C11orf54 OS=Homo sapiens OX=9606 GN=C11orf54 PE=1 SV=1" "0.000" "False" "13.534" "17" "4" "7" "4" "315" "35.1" "6.70" "14.61" "4" "" "nucleus" "other molecular function" "Pf08925" "28970" "ENSG00000182919" "C11orf54" "A8K850; hsa:28970; Q6FI88; Q6XYB0; Q96EI3; Q96IX1; Q9H0W9; Q9Y6B4" "" "" "0" "0" "1.224" "1.178" "0.993" "0.972" "1.031" "1.359" "1.101" "1.269" "0.741" "149.2" "182.6" "175.8" "148.2" "145.0" "153.7" "202.8" "164.3" "189.2" "110.5" "" "" "" "" "" "" "" "" "" "" "89.3" "94.9" "97.3" "69.6" "67.2" "78.7" "94.3" "73.7" "102.7" "110.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-792306396308701389" "False" "High" "IsMasterProtein" "Q9Y2W1" "Thyroid hormone receptor-associated protein 3 OS=Homo sapiens OX=9606 GN=THRAP3 PE=1 SV=2" "0.000" "False" "13.514" "6" "6" "7" "6" "955" "108.6" "10.15" "16.42" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf15440" "9967" "ENSG00000054118" "THRAP3" "D3DPS5; hsa:9967; Q5VTK6; Q9Y2W1" "Interactome of polycomb repressive complex 2 (PRC2)" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation" "3" "0" "1.027" "1.166" "1.133" "1.111" "1.041" "1.162" "1.248" "1.220" "0.946" "282.2" "290.0" "329.1" "319.7" "313.5" "293.8" "328.1" "352.3" "344.3" "267.0" "" "" "" "" "" "" "" "" "" "" "168.9" "150.7" "182.2" "150.1" "145.3" "150.4" "152.5" "158.2" "186.8" "267.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3659608677254824690" "False" "High" "IsMasterProtein" "P53582" "Methionine aminopeptidase 1 OS=Homo sapiens OX=9606 GN=METAP1 PE=1 SV=2" "0.000" "False" "13.500" "8" "3" "7" "3" "386" "43.2" "7.17" "17.16" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00557, Pf15801" "23173" "ENSG00000164024" "METAP1" "B4E2E6; hsa:23173; P53582" "" "Inactivation, recovery and regulation of the phototransduction cascade" "1" "0" "1.038" "0.965" "0.991" "1.086" "1.173" "1.116" "0.921" "1.017" "1.209" "168.0" "174.4" "162.1" "166.4" "182.3" "197.0" "187.4" "154.8" "170.8" "203.0" "" "" "" "" "" "" "" "" "" "" "100.5" "90.6" "89.8" "78.1" "84.5" "100.8" "87.1" "69.5" "92.7" "203.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "699961986535192658" "False" "High" "IsMasterProtein" "P84095" "Rho-related GTP-binding protein RhoG OS=Homo sapiens OX=9606 GN=RHOG PE=1 SV=1" "0.000" "False" "13.473" "24" "4" "4" "3" "191" "21.3" "8.12" "10.22" "4" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00071" "391" "ENSG00000177105" "RHOG" "hsa:391; P35238; P84095; Q8NI04" "Brain-derived neurotrophic factor (BDNF) signaling pathway" "PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RHOG GTPase cycle; Neutrophil degranulation; RHO GTPases activate KTN1" "8" "0" "0.951" "1.181" "0.981" "1.139" "0.988" "0.941" "0.985" "1.081" "1.289" "223.9" "212.9" "264.4" "219.7" "255.0" "221.3" "210.6" "220.5" "241.9" "288.6" "" "" "" "" "" "" "" "" "" "" "134.0" "110.6" "146.4" "103.1" "118.2" "113.3" "97.9" "99.0" "131.3" "288.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1566941551472469516" "False" "High" "IsMasterProtein" "O60508" "Pre-mRNA-processing factor 17 OS=Homo sapiens OX=9606 GN=CDC40 PE=1 SV=1" "0.000" "False" "13.471" "6" "4" "4" "4" "579" "65.5" "7.06" "12.39" "4" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "nucleic acid binding activity" "Pf00400" "51362" "ENSG00000168438" "CDC40" "B2RBC5; hsa:51362; O60508; O75471; Q5SRN0; Q9UPG1" "mRNA processing" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "5" "0" "1.153" "1.260" "1.108" "1.094" "1.282" "0.912" "1.169" "1.280" "0.882" "213.3" "245.9" "268.7" "236.2" "233.3" "273.4" "194.4" "249.2" "273.0" "188.1" "" "" "" "" "" "" "" "" "" "" "127.6" "127.8" "148.8" "110.9" "108.1" "139.9" "90.4" "111.9" "148.1" "188.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "864018122010782004" "False" "High" "IsMasterProtein" "P35080" "Profilin-2 OS=Homo sapiens OX=9606 GN=PFN2 PE=1 SV=3" "0.000" "False" "13.466" "20" "2" "5" "2" "140" "15.0" "6.99" "15.25" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00235" "5217" "ENSG00000070087" "PFN2" "B2R4C8; D3DNI4; hsa:5217; P35080; Q4VBQ4; Q8WVF9; Q9HBK2" "Physico-chemical features and toxicity-associated pathways" "RHO GTPases Activate Formins; Signaling by ROBO receptors" "3" "0" "1.060" "0.709" "1.059" "1.196" "1.125" "1.085" "0.902" "0.999" "0.687" "54.8" "58.1" "38.9" "58.0" "65.6" "61.6" "59.5" "49.5" "54.7" "37.7" "" "" "" "" "" "" "" "" "" "" "32.8" "30.2" "21.5" "27.3" "30.4" "31.6" "27.6" "22.2" "29.7" "37.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2081784358139501247" "False" "High" "IsMasterProtein" "Q96ME1" "F-box/LRR-repeat protein 18 OS=Homo sapiens OX=9606 GN=FBXL18 PE=1 SV=3" "0.000" "False" "13.459" "6" "4" "9" "4" "718" "78.9" "8.27" "13.80" "4" "protein metabolism;other metabolic processes" "cytosol;other cell component" "" "Pf12937, Pf19729" "80028" "ENSG00000155034" "FBXL18" "A0A024R857; B3KTC9; B4DH63; H0Y6I6; hsa:80028; Q96ME1; Q9BR90; Q9BTC7; Q9HAK7" "" "Antigen processing: Ubiquitination & Proteasome degradation; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Neddylation" "3" "0" "0.896" "0.888" "0.930" "1.097" "0.938" "0.793" "1.050" "0.952" "1.082" "73.9" "66.2" "65.6" "68.7" "81.0" "69.3" "58.6" "77.5" "70.4" "79.9" "" "" "" "" "" "" "" "" "" "" "44.2" "34.4" "36.3" "32.2" "37.6" "35.5" "27.2" "34.8" "38.2" "79.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3304952133381549298" "False" "High" "IsMasterProtein" "Q99614" "Tetratricopeptide repeat protein 1 OS=Homo sapiens OX=9606 GN=TTC1 PE=1 SV=1" "0.000" "False" "13.451" "16" "5" "7" "5" "292" "33.5" "4.84" "20.47" "5" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00515, Pf13181" "7265" "ENSG00000113312" "TTC1" "B2RCT2; D3DQJ8; hsa:7265; Q99614; Q9BVT3" "" "" "0" "0" "1.020" "0.958" "0.951" "1.088" "1.032" "1.072" "0.997" "0.965" "0.918" "747.1" "762.1" "716.0" "710.4" "813.2" "771.2" "800.7" "744.6" "721.1" "685.8" "" "" "" "" "" "" "" "" "" "" "447.1" "396.0" "396.5" "333.5" "376.9" "394.8" "372.3" "334.3" "391.2" "685.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6380773280211833227" "False" "High" "IsMasterProtein" "Q9Y508" "E3 ubiquitin-protein ligase RNF114 OS=Homo sapiens OX=9606 GN=RNF114 PE=1 SV=1" "0.000" "False" "13.444" "31" "5" "6" "5" "228" "25.7" "7.25" "12.00" "5" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf05605, Pf13445, Pf18574" "55905" "ENSG00000124226" "RNF114" "B2RDQ9; B4DWY5; E1P627; hsa:55905; Q6N0B0; Q9Y508" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.896" "1.053" "1.172" "0.901" "0.981" "1.204" "1.044" "1.025" "0.705" "72.4" "64.8" "76.2" "84.8" "65.2" "71.0" "87.1" "75.5" "74.2" "51.0" "" "" "" "" "" "" "" "" "" "" "43.3" "33.7" "42.2" "39.8" "30.2" "36.3" "40.5" "33.9" "40.2" "51.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4678408440687391789" "False" "High" "IsMasterProtein" "Q9UFW8" "CGG triplet repeat-binding protein 1 OS=Homo sapiens OX=9606 GN=CGGBP1 PE=1 SV=2" "0.000" "False" "13.439" "25" "4" "6" "4" "167" "18.8" "8.95" "16.64" "4" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "8545" "ENSG00000163320" "CGGBP1" "D3DU38; hsa:8545; O15183; Q9UFW8" "" "" "0" "0" "0.955" "0.996" "0.924" "1.191" "1.059" "0.894" "1.080" "1.139" "1.043" "99.9" "95.4" "99.5" "92.3" "119.0" "105.8" "89.3" "107.8" "113.8" "104.2" "" "" "" "" "" "" "" "" "" "" "59.8" "49.6" "55.1" "43.3" "55.2" "54.1" "41.5" "48.4" "61.7" "104.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8750059555873910244" "False" "High" "IsMasterProtein" "Q96KB5" "Lymphokine-activated killer T-cell-originated protein kinase OS=Homo sapiens OX=9606 GN=PBK PE=1 SV=3" "0.000" "False" "13.394" "18" "6" "6" "6" "322" "36.1" "5.12" "12.49" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "kinase activity;other molecular function" "Pf00069" "55872" "ENSG00000168078" "PBK" "B4DX68; D3DST2; hsa:55872; Q96KB5; Q9NPD9; Q9NYL7; Q9NZK6" "4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling" "" "2" "0" "1.109" "1.382" "1.454" "1.373" "1.120" "1.255" "0.010" "1.298" "20.968" "22.3" "24.7" "30.8" "32.4" "30.6" "25.0" "28.0" "0.0" "29.0" "467.7" "" "" "" "" "" "" "" "" "" "" "13.3" "12.8" "17.1" "15.2" "14.2" "12.8" "13.0" "0.0" "15.7" "467.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5778501702482241288" "False" "High" "IsMasterProtein" "P41182" "B-cell lymphoma 6 protein OS=Homo sapiens OX=9606 GN=BCL6 PE=1 SV=1" "0.000" "False" "13.384" "7" "5" "6" "5" "706" "78.8" "7.94" "13.93" "5" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "604" "ENSG00000113916" "BCL6" "A7E241; B8PSA7; D3DNV5; hsa:604; P41182" "B cell receptor signaling pathway; Vitamin D receptor pathway; MECP2 and associated Rett syndrome; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Extrafollicular and follicular B cell activation by SARS-CoV-2; DNA damage response (only ATM dependent)" "Interleukin-4 and Interleukin-13 signaling; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; FOXO-mediated transcription of cell death genes" "9" "0" "0.946" "0.811" "1.032" "1.060" "1.052" "0.845" "0.840" "0.812" "0.792" "293.4" "277.4" "238.1" "302.8" "311.1" "308.7" "247.8" "246.6" "238.2" "232.4" "" "" "" "" "" "" "" "" "" "" "175.6" "144.2" "131.8" "142.2" "144.2" "158.1" "115.2" "110.7" "129.2" "232.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1741293636862823993" "False" "High" "IsMasterProtein" "Q5T1M5" "FK506-binding protein 15 OS=Homo sapiens OX=9606 GN=FKBP15 PE=1 SV=2" "0.000" "False" "13.380" "5" "5" "5" "5" "1219" "133.5" "5.20" "10.32" "5" "transport" "other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00254" "23307" "ENSG00000119321" "FKBP15" "hsa:23307; Q05DK8; Q5T1M2; Q5T1M5; Q6DD85; Q9Y4D0" "TYROBP causal network in microglia" "" "1" "0" "0.983" "1.306" "0.980" "1.035" "1.361" "1.142" "0.612" "1.109" "5.616" "83.0" "81.6" "108.4" "81.4" "85.9" "113.0" "94.8" "50.8" "92.1" "466.4" "" "" "" "" "" "" "" "" "" "" "49.7" "42.4" "60.0" "38.2" "39.8" "57.9" "44.1" "22.8" "50.0" "466.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2608297445267441955" "False" "High" "IsMasterProtein" "Q96QR8" "Transcriptional regulator protein Pur-beta OS=Homo sapiens OX=9606 GN=PURB PE=1 SV=3" "0.000" "False" "13.380" "14" "4" "5" "4" "312" "33.2" "5.43" "9.89" "4" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf04845" "5814" "ENSG00000146676" "PURB" "A4D2L7; hsa:5814; Q96QR8" "" "" "0" "0" "0.964" "0.847" "1.142" "1.072" "0.839" "1.089" "1.038" "0.999" "0.611" "195.1" "188.1" "165.2" "222.8" "209.1" "163.8" "212.5" "202.5" "194.9" "119.2" "" "" "" "" "" "" "" "" "" "" "116.8" "97.7" "91.5" "104.6" "96.9" "83.8" "98.8" "90.9" "105.7" "119.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5765443992663171126" "False" "High" "IsMasterProtein" "Q86UE8" "Serine/threonine-protein kinase tousled-like 2 OS=Homo sapiens OX=9606 GN=TLK2 PE=1 SV=2" "0.000" "False" "13.374" "6" "5" "6" "3" "772" "87.6" "8.41" "13.25" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "11011" "ENSG00000146872" "TLK2" "D3DU07; hsa:11011; Q86UE8; Q9UKI7; Q9Y4F7" "miRNA regulation of DNA damage response; DNA damage response" "" "2" "0" "1.101" "0.985" "1.036" "1.179" "1.062" "0.988" "1.062" "1.084" "1.112" "261.2" "287.5" "257.2" "270.6" "308.0" "277.5" "258.2" "277.5" "283.2" "290.6" "" "" "" "" "" "" "" "" "" "" "156.3" "149.4" "142.5" "127.0" "142.8" "142.1" "120.1" "124.6" "153.7" "290.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "247879969936268411" "False" "High" "IsMasterProtein" "O94992" "Protein HEXIM1 OS=Homo sapiens OX=9606 GN=HEXIM1 PE=1 SV=1" "0.000" "False" "13.345" "10" "4" "4" "3" "359" "40.6" "4.89" "12.25" "4" "stress response;developmental processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf15313" "10614" "ENSG00000186834" "HEXIM1" "B2R8Y5; hsa:10614; O94992" "Initiation of transcription and translation elongation at the HIV-1 LTR" "" "1" "0" "0.988" "1.076" "0.953" "1.053" "1.083" "1.073" "1.254" "1.105" "0.479" "257.1" "254.1" "276.7" "245.1" "270.7" "278.5" "276.0" "322.3" "284.0" "123.3" "" "" "" "" "" "" "" "" "" "" "153.9" "132.0" "153.2" "115.1" "125.5" "142.5" "128.3" "144.7" "154.1" "123.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1721155162359169472" "False" "High" "IsMasterProtein" "Q9UBQ0" "Vacuolar protein sorting-associated protein 29 OS=Homo sapiens OX=9606 GN=VPS29 PE=1 SV=1" "0.000" "False" "13.343" "23" "4" "10" "4" "182" "20.5" "6.79" "32.66" "4" "transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf12850" "51699" "ENSG00000111237" "VPS29" "hsa:51699; Q502Y5; Q6FIF8; Q6IAH3; Q9H0W0; Q9NRP1; Q9NRU7; Q9UBQ0" "" "WNT ligand biogenesis and trafficking" "1" "0" "0.978" "1.075" "0.953" "0.969" "0.969" "1.032" "1.048" "1.083" "0.642" "871.5" "852.0" "937.0" "830.9" "844.1" "844.6" "899.4" "913.1" "943.8" "559.4" "" "" "" "" "" "" "" "" "" "" "521.5" "442.8" "518.9" "390.1" "391.3" "432.3" "418.2" "409.9" "512.0" "559.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "523405854747225660" "False" "High" "IsMasterProtein" "Q16222" "UDP-N-acetylhexosamine pyrophosphorylase OS=Homo sapiens OX=9606 GN=UAP1 PE=1 SV=3" "0.000" "False" "13.285" "8" "4" "6" "4" "522" "58.7" "6.33" "17.14" "4" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf01704" "6675" "ENSG00000117143" "UAP1" "B2R6R8; hsa:6675; Q16222; Q5VTA9; Q5VTB0; Q5VTB1; Q96GM2" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "0" "1.219" "0.991" "1.303" "1.169" "1.006" "1.454" "1.348" "1.453" "1.048" "57.1" "69.5" "56.6" "74.4" "66.7" "57.4" "83.0" "76.9" "82.9" "59.8" "" "" "" "" "" "" "" "" "" "" "34.2" "36.1" "31.3" "34.9" "30.9" "29.4" "38.6" "34.5" "45.0" "59.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7785490494886001566" "False" "High" "IsMasterProtein" "A6NC98" "Coiled-coil domain-containing protein 88B OS=Homo sapiens OX=9606 GN=CCDC88B PE=1 SV=1" "0.000" "False" "13.278" "4" "5" "5" "5" "1476" "164.7" "5.11" "9.20" "5" "cell organization and biogenesis;stress response;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf19047" "283234" "ENSG00000168071" "CCDC88B" "A5D8Y5; A6NC98; B5MDM2; hsa:283234; Q05BL2; Q6RUV3; Q8N1Q6; Q8NF44; Q9H0H1" "" "" "0" "0" "1.331" "1.309" "1.454" "1.419" "1.331" "1.122" "0.914" "1.194" "4.750" "58.6" "78.0" "76.8" "85.3" "83.2" "78.1" "65.8" "53.6" "70.0" "278.5" "" "" "" "" "" "" "" "" "" "" "35.1" "40.5" "42.5" "40.0" "38.6" "40.0" "30.6" "24.1" "38.0" "278.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2765155610572928931" "False" "High" "IsMasterProtein" "Q8IZ73" "Pseudouridylate synthase RPUSD2 OS=Homo sapiens OX=9606 GN=RPUSD2 PE=1 SV=2" "0.000" "False" "13.253" "9" "4" "4" "4" "545" "61.3" "7.17" "8.51" "4" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00849" "27079" "ENSG00000166133" "RPUSD2" "B4DDD1; hsa:27079; Q7L989; Q8IZ73; Q92939; Q96IA7; Q96N50" "" "" "0" "0" "0.924" "1.269" "1.011" "1.226" "1.161" "1.117" "1.125" "1.257" "0.688" "68.4" "63.2" "86.7" "69.1" "83.8" "79.4" "76.4" "76.9" "85.9" "47.0" "" "" "" "" "" "" "" "" "" "" "40.9" "32.8" "48.0" "32.4" "38.9" "40.6" "35.5" "34.5" "46.6" "47.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-390863097898701106" "False" "High" "IsMasterProtein" "Q14657" "EKC/KEOPS complex subunit LAGE3 OS=Homo sapiens OX=9606 GN=LAGE3 PE=1 SV=2" "0.000" "False" "13.238" "27" "2" "6" "2" "143" "14.8" "8.63" "9.10" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf09341" "8270" "ENSG00000196976" "LAGE3" "hsa:8270; Q14657; Q5HY39; Q8IZ78" "" "tRNA modification in the nucleus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8306155883597695001" "False" "High" "IsMasterProtein" "Q9NTM9" "Copper homeostasis protein cutC homolog OS=Homo sapiens OX=9606 GN=CUTC PE=1 SV=1" "0.000" "False" "13.230" "18" "4" "5" "4" "273" "29.3" "8.18" "9.85" "4" "cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03932" "51076" "ENSG00000119929" "CUTC" "hsa:51076; Q5TCZ8; Q9NTM9; Q9Y321" "" "Ion transport by P-type ATPases" "1" "0" "1.026" "1.067" "1.006" "1.204" "1.065" "1.197" "1.224" "1.131" "0.798" "185.1" "189.9" "197.6" "186.1" "222.9" "197.1" "221.6" "226.5" "209.3" "147.7" "" "" "" "" "" "" "" "" "" "" "110.8" "98.7" "109.4" "87.4" "103.3" "100.9" "103.0" "101.7" "113.5" "147.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1630318732500359632" "False" "High" "IsMasterProtein" "P62280" "Small ribosomal subunit protein uS17 OS=Homo sapiens OX=9606 GN=RPS11 PE=1 SV=3" "0.000" "False" "13.219" "26" "5" "7" "5" "158" "18.4" "10.30" "18.61" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00366, Pf16205" "6205" "ENSG00000142534" "RPS11" "B2R4F5; hsa:6205; P04643; P62280; Q498Y6; Q6IRY0" "VEGFA-VEGFR2 signaling; IL-18 signaling pathway; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "21" "0" "0.864" "1.003" "1.072" "1.058" "0.992" "0.998" "0.906" "1.061" "1.669" "392.8" "339.3" "394.0" "421.0" "415.6" "389.6" "392.2" "355.8" "416.7" "655.7" "" "" "" "" "" "" "" "" "" "" "235.1" "176.3" "218.2" "197.6" "192.6" "199.5" "182.4" "159.7" "226.1" "655.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3162421235115001887" "False" "High" "IsMasterProtein" "L0R819" "ASNSD1 upstream open reading frame protein OS=Homo sapiens OX=9606 GN=ASDURF PE=1 SV=1" "0.000" "False" "13.196" "28" "3" "4" "3" "96" "11.2" "8.88" "9.46" "3" "other biological processes" "other cell component" "" "" "" "ENSG00000286053" "ASDURF" "L0R819" "" "" "0" "0" "1.136" "1.063" "1.117" "1.130" "1.137" "1.189" "1.216" "1.050" "0.649" "187.6" "213.0" "199.3" "209.6" "211.9" "213.3" "223.0" "228.1" "197.0" "121.8" "" "" "" "" "" "" "" "" "" "" "112.3" "110.7" "110.4" "98.4" "98.2" "109.2" "103.7" "102.4" "106.9" "121.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6442873191784740439" "False" "High" "IsMasterProtein" "Q9BXW7" "Haloacid dehalogenase-like hydrolase domain-containing 5 OS=Homo sapiens OX=9606 GN=HDHD5 PE=1 SV=1" "0.000" "False" "13.177" "9" "3" "4" "3" "423" "46.3" "8.13" "12.77" "3" "other metabolic processes" "mitochondrion" "" "Pf13344" "27440" "ENSG00000069998" "HDHD5" "B2RCK5; Q9BXW7; Q9BXW8; Q9NWA8; Q9NX41" "" "" "0" "0" "0.953" "0.916" "1.081" "1.107" "1.157" "0.797" "1.016" "1.034" "2.275" "55.7" "53.0" "51.0" "60.2" "61.6" "64.4" "44.4" "56.6" "57.5" "126.6" "" "" "" "" "" "" "" "" "" "" "33.3" "27.6" "28.2" "28.3" "28.6" "33.0" "20.6" "25.4" "31.2" "126.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3988284594388072596" "False" "High" "IsMasterProtein" "Q92974" "Rho guanine nucleotide exchange factor 2 OS=Homo sapiens OX=9606 GN=ARHGEF2 PE=1 SV=4" "0.000" "False" "13.160" "5" "5" "8" "5" "986" "111.5" "7.27" "11.17" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00621, Pf17838" "9181" "ENSG00000116584" "ARHGEF2" "D3DVA6; hsa:9181; O75142; Q15079; Q5VY92; Q8TDA3; Q8WUG4; Q92974; Q9H023" "Pathogenic Escherichia coli infection" "RHOA GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle" "5" "0" "1.080" "1.068" "1.148" "1.160" "1.109" "1.185" "0.844" "1.119" "5.882" "84.8" "91.6" "90.6" "97.3" "98.4" "94.0" "100.5" "71.6" "94.9" "498.9" "" "" "" "" "" "" "" "" "" "" "50.8" "47.6" "50.2" "45.7" "45.6" "48.1" "46.7" "32.1" "51.5" "498.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4844902181037291409" "False" "High" "IsMasterProtein" "P62314" "Small nuclear ribonucleoprotein Sm D1 OS=Homo sapiens OX=9606 GN=SNRPD1 PE=1 SV=1" "0.000" "False" "13.155" "11" "2" "5" "2" "119" "13.3" "11.56" "16.75" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6632" "ENSG00000167088" "SNRPD1" "B5BTZ1; hsa:6632; P13641; P62314" "mRNA processing" "snRNP Assembly; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway" "5" "0" "1.003" "0.896" "0.981" "0.995" "1.043" "1.020" "1.041" "1.035" "0.650" "356.1" "356.9" "319.1" "349.3" "354.1" "371.4" "363.2" "370.7" "368.6" "231.5" "" "" "" "" "" "" "" "" "" "" "213.1" "185.5" "176.7" "164.0" "164.1" "190.2" "168.9" "166.4" "200.0" "231.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5585916410181359903" "False" "High" "IsMasterProtein" "Q6IQ49" "Splicing regulator SDE2 OS=Homo sapiens OX=9606 GN=SDE2 PE=1 SV=1" "0.000" "False" "13.149" "9" "4" "4" "4" "451" "49.7" "6.05" "13.42" "4" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf13019, Pf13297" "163859" "ENSG00000143751" "SDE2" "A8K4P3; hsa:163859; Q5TD36; Q6IQ49; Q6ZS26; Q8NAG7" "" "mRNA Splicing - Major Pathway" "1" "0" "1.039" "1.129" "0.969" "1.016" "0.978" "1.166" "1.088" "0.912" "0.887" "269.5" "280.1" "304.2" "261.0" "273.7" "263.6" "314.1" "293.3" "245.9" "239.1" "" "" "" "" "" "" "" "" "" "" "161.3" "145.6" "168.5" "122.5" "126.8" "135.0" "146.1" "131.7" "133.4" "239.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6802113826893248650" "False" "High" "IsMasterProtein" "P07108" "Acyl-CoA-binding protein OS=Homo sapiens OX=9606 GN=DBI PE=1 SV=2" "0.000" "False" "13.138" "32" "2" "8" "2" "87" "10.0" "6.57" "22.42" "2" "other metabolic processes;other biological processes" "ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00887" "1622" "ENSG00000155368" "DBI" "B8ZWD2; B8ZWD6; B8ZWD7; hsa:1622; P07108; P08869; Q4VWZ6; Q53SQ7; Q6IB48; Q9UCI8" "Sterol regulatory element-binding proteins (SREBP) signaling; PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Fatty acid transporters" "Mitochondrial Fatty Acid Beta-Oxidation" "6" "0" "0.956" "0.822" "0.811" "0.899" "0.783" "0.960" "0.963" "0.840" "0.397" "733.1" "700.9" "603.0" "594.8" "659.1" "573.8" "703.8" "705.6" "615.8" "290.8" "" "" "" "" "" "" "" "" "" "" "438.7" "364.2" "333.9" "279.2" "305.5" "293.8" "327.2" "316.8" "334.1" "290.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8547587141624532923" "False" "High" "IsMasterProtein" "Q9UKV8" "Protein argonaute-2 OS=Homo sapiens OX=9606 GN=AGO2 PE=1 SV=3" "0.000" "False" "13.133" "7" "5" "6" "5" "859" "97.1" "9.19" "6.62" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02170, Pf02171, Pf08699, Pf16486, Pf16487, Pf16488" "27161" "ENSG00000123908" "AGO2" "Q8TCZ5; Q8WV58; Q96ID1; Q9UKV8" "exRNA mechanism of action and biogenesis; Fragile X syndrome; Male infertility; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "MAPK6/MAPK4 signaling; Transcriptional regulation by small RNAs; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Small interfering RNA (siRNA) biogenesis; M-decay: degradation of maternal mRNAs by maternally stored factors; TP53 Regulates Metabolic Genes; Ca2+ pathway; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; MicroRNA (miRNA) biogenesis; Nuclear events stimulated by ALK signaling in cancer; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "24" "0" "1.012" "0.915" "1.058" "0.674" "1.088" "0.794" "1.358" "0.870" "0.605" "39.0" "39.5" "35.7" "41.2" "26.3" "42.4" "30.9" "53.0" "33.9" "23.6" "" "" "" "" "" "" "" "" "" "" "23.3" "20.5" "19.8" "19.4" "12.2" "21.7" "14.4" "23.8" "18.4" "23.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8481404637455697567" "False" "High" "IsMasterProtein" "Q9C0B1" "Alpha-ketoglutarate-dependent dioxygenase FTO OS=Homo sapiens OX=9606 GN=FTO PE=1 SV=3" "0.000" "False" "13.126" "10" "5" "8" "5" "505" "58.2" "5.22" "13.01" "5" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12933, Pf12934" "79068" "ENSG00000140718" "FTO" "A2RUH1; B2RNS0; hsa:79068; Q0P676; Q7Z785; Q9C0B1" "FTO obesity variant mechanism" "Reversal of alkylation damage by DNA dioxygenases" "2" "0" "1.056" "1.104" "1.115" "1.181" "1.118" "1.139" "1.016" "1.230" "0.914" "190.9" "201.7" "210.8" "212.8" "225.4" "213.4" "217.5" "193.9" "234.9" "174.6" "" "" "" "" "" "" "" "" "" "" "114.3" "104.8" "116.7" "99.9" "104.5" "109.3" "101.2" "87.1" "127.5" "174.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4375122853346024923" "False" "High" "IsMasterProtein" "Q9C0E2" "Exportin-4 OS=Homo sapiens OX=9606 GN=XPO4 PE=1 SV=2" "0.000" "False" "13.094" "5" "6" "6" "6" "1151" "130.1" "5.05" "14.79" "6" "transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08767" "64328" "ENSG00000132953" "XPO4" "hsa:64328; Q5VUZ5; Q8N3V6; Q9C0E2; Q9H934" "eIF5A regulation in response to inhibition of the nuclear export system" "" "1" "0" "1.068" "1.011" "0.977" "1.219" "1.111" "0.962" "1.048" "1.110" "1.411" "255.7" "273.1" "258.5" "249.9" "311.6" "284.0" "245.8" "267.9" "283.8" "360.7" "" "" "" "" "" "" "" "" "" "" "153.0" "141.9" "143.2" "117.3" "144.4" "145.4" "114.3" "120.3" "154.0" "360.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4996428185622591073" "False" "High" "IsMasterProtein" "Q9NZB2" "Constitutive coactivator of PPAR-gamma-like protein 1 OS=Homo sapiens OX=9606 GN=FAM120A PE=1 SV=2" "0.000" "False" "13.085" "4" "4" "5" "4" "1118" "121.8" "8.88" "14.14" "4" "" "plasma membrane;other membranes;cytosol;nucleus" "" "" "23196" "ENSG00000048828" "FAM120A" "A6NGU0; C4AMC6; hsa:23196; O60649; Q14688; Q4VXF4; Q4VXF5; Q4VXG2; Q86V69; Q96I21; Q9NZB1; Q9NZB2" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.075" "0.951" "0.735" "1.529" "1.101" "1.063" "1.905" "1.193" "0.903" "16.6" "17.8" "15.8" "12.2" "25.3" "18.2" "17.6" "31.6" "19.8" "15.0" "" "" "" "" "" "" "" "" "" "" "9.9" "9.3" "8.7" "5.7" "11.7" "9.3" "8.2" "14.2" "10.7" "15.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5857120018545354279" "False" "High" "IsMasterProtein" "Q8NFH3" "Nucleoporin Nup43 OS=Homo sapiens OX=9606 GN=NUP43 PE=1 SV=1" "0.000" "False" "13.082" "11" "4" "8" "4" "380" "42.1" "5.63" "21.92" "4" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "348995" "ENSG00000120253" "NUP43" "B4E2F0; hsa:348995; Q8NFH3; Q9H8S0" "" "Separation of Sister Chromatids; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; tRNA processing in the nucleus; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "35" "0" "0.956" "0.938" "1.016" "1.125" "1.078" "1.222" "1.087" "1.183" "0.767" "174.9" "167.2" "164.0" "177.6" "196.8" "188.6" "213.7" "190.2" "206.8" "134.1" "" "" "" "" "" "" "" "" "" "" "104.6" "86.9" "90.8" "83.4" "91.2" "96.5" "99.4" "85.4" "112.2" "134.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2576467063852337379" "False" "High" "IsMasterProtein" "Q12912" "Inositol 1,4,5-triphosphate receptor associated 2 OS=Homo sapiens OX=9606 GN=IRAG2 PE=1 SV=3" "0.000" "False" "13.070" "8" "4" "5" "4" "555" "62.1" "5.85" "9.11" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf05781" "4033" "ENSG00000118308" "IRAG2" "A0AVM2; B4E077; hsa:4033; Q12912; Q8N301" "" "Neutrophil degranulation" "1" "0" "1.047" "1.111" "1.086" "0.986" "0.999" "1.215" "1.156" "1.200" "1.187" "133.0" "139.3" "147.6" "144.3" "131.0" "132.9" "161.6" "153.6" "159.6" "157.8" "" "" "" "" "" "" "" "" "" "" "79.6" "72.4" "81.8" "67.8" "60.7" "68.0" "75.1" "69.0" "86.6" "157.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1498458301552967093" "False" "High" "IsMasterProtein" "P13716" "Delta-aminolevulinic acid dehydratase OS=Homo sapiens OX=9606 GN=ALAD PE=1 SV=1" "0.000" "False" "13.055" "13" "3" "4" "3" "330" "36.3" "6.79" "7.17" "3" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf00490" "210" "ENSG00000148218" "ALAD" "A8K375; B2R6F2; hsa:210; P13716; Q16870; Q16871; Q9BVQ9" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Neutrophil degranulation; Heme biosynthesis" "4" "0" "1.205" "1.408" "1.825" "1.713" "1.587" "1.520" "1.702" "1.990" "1.226" "13.5" "16.3" "19.0" "24.6" "23.1" "21.4" "20.5" "23.0" "26.9" "16.5" "" "" "" "" "" "" "" "" "" "" "8.1" "8.4" "10.5" "11.6" "10.7" "11.0" "9.5" "10.3" "14.6" "16.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4212925493234983848" "False" "High" "IsMasterProtein" "Q14289" "Protein-tyrosine kinase 2-beta OS=Homo sapiens OX=9606 GN=PTK2B PE=1 SV=2" "0.000" "False" "13.049" "4" "4" "5" "4" "1009" "115.8" "6.25" "15.21" "4" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "transporter activity;kinase activity;other molecular function" "Pf00373, Pf03623, Pf07714, Pf18038, Pf21477" "2185" "ENSG00000120899" "PTK2B" "D3DST0; hsa:2185; Q13475; Q14289; Q14290; Q16709; Q6PID4" "IL-7 signaling pathway; Androgen receptor network in prostate cancer; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Hepatocyte growth factor receptor signaling; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-2 signaling pathway; CCL18 signaling pathway; NPHP1 deletion syndrome; 8q11.23 (RB1CC1) copy number variation; HDAC6 interactions in the central nervous system; T-cell receptor signaling pathway" "RHOU GTPase cycle; Interleukin-2 signaling; VEGFA-VEGFR2 Pathway; Signal regulatory protein family interactions" "21" "0" "1.009" "0.970" "0.985" "1.167" "0.881" "0.977" "0.593" "0.768" "3.764" "169.3" "170.8" "164.3" "166.9" "197.6" "149.3" "165.4" "100.3" "130.1" "637.3" "" "" "" "" "" "" "" "" "" "" "101.3" "88.8" "91.0" "78.3" "91.6" "76.4" "76.9" "45.0" "70.6" "637.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3185905528720532686" "False" "High" "IsMasterProtein" "P01903" "HLA class II histocompatibility antigen, DR alpha chain OS=Homo sapiens OX=9606 GN=HLA-DRA PE=1 SV=2" "0.000" "False" "13.030" "18" "3" "5" "3" "254" "28.6" "5.00" "13.16" "3" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00993, Pf07654" "3122" "ENSG00000204287; ENSG00000206308; ENSG00000226260; ENSG00000227993; ENSG00000228987; ENSG00000230726; ENSG00000234794; ENSG00000277263" "HLA-DRA" "A2BET4; hsa:3122; P01903; Q30160; Q6IAZ1; Q861I2; Q9TP70" "Allograft rejection; PI3K/AKT/mTOR - vitamin D3 signaling; Ebola virus infection in host; Male infertility; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway; Cell interactions of the pancreatic cancer microenvironment; Cytokines and inflammatory response; 11p11.2 copy number variation syndrome" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "16" "0" "0.659" "0.930" "1.183" "1.188" "0.827" "0.683" "1.353" "1.388" "0.515" "26.4" "17.4" "24.5" "31.2" "31.3" "21.8" "18.0" "35.7" "36.6" "13.6" "" "" "" "" "" "" "" "" "" "" "15.8" "9.0" "13.6" "14.6" "14.5" "11.2" "8.4" "16.0" "19.9" "13.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3054856418516569750" "False" "High" "IsMasterProtein" "Q8IZ07" "Ankyrin repeat domain-containing protein 13A OS=Homo sapiens OX=9606 GN=ANKRD13A PE=1 SV=3" "0.000" "False" "13.025" "5" "3" "5" "3" "590" "67.6" "5.02" "12.58" "3" "other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf11904, Pf12796" "88455" "ENSG00000076513" "ANKRD13A" "hsa:88455; O60736; Q8IZ07" "" "" "0" "0" "1.320" "1.477" "1.241" "1.147" "2.174" "1.432" "1.588" "1.318" "2.210" "14.6" "19.2" "21.5" "18.1" "16.7" "31.7" "20.9" "23.1" "19.2" "32.2" "" "" "" "" "" "" "" "" "" "" "8.7" "10.0" "11.9" "8.5" "7.7" "16.2" "9.7" "10.4" "10.4" "32.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7890686096526149286" "False" "High" "IsMasterProtein" "Q13347" "Eukaryotic translation initiation factor 3 subunit I OS=Homo sapiens OX=9606 GN=EIF3I PE=1 SV=1" "0.000" "False" "12.979" "10" "3" "3" "3" "325" "36.5" "5.64" "10.81" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00400, Pf12894" "8668" "ENSG00000084623" "EIF3I" "hsa:8668; Q13347" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "8" "0" "0.995" "0.959" "1.044" "0.985" "1.212" "0.974" "1.034" "1.156" "5.027" "158.5" "157.7" "152.0" "165.4" "156.2" "192.1" "154.4" "163.9" "183.2" "796.7" "" "" "" "" "" "" "" "" "" "" "94.8" "82.0" "84.2" "77.7" "72.4" "98.3" "71.8" "73.6" "99.4" "796.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "997292728151378108" "False" "High" "IsMasterProtein" "P32519" "ETS-related transcription factor Elf-1 OS=Homo sapiens OX=9606 GN=ELF1 PE=1 SV=2" "0.000" "False" "12.967" "9" "4" "5" "4" "619" "67.5" "5.21" "11.62" "4" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf12310" "1997" "ENSG00000120690" "ELF1" "B4E2I5; E9PDQ9; hsa:1997; P32519; Q8N6F6; Q9UDE1" "" "RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX1 regulates transcription of genes involved in BCR signaling" "2" "0" "0.999" "1.336" "1.299" "1.395" "0.929" "1.275" "0.925" "1.125" "1.755" "50.4" "50.4" "67.4" "65.5" "70.4" "46.9" "64.3" "46.6" "56.7" "88.5" "" "" "" "" "" "" "" "" "" "" "30.2" "26.2" "37.3" "30.8" "32.6" "24.0" "29.9" "20.9" "30.8" "88.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-109273256828227415" "False" "High" "IsMasterProtein" "Q07866" "Kinesin light chain 1 OS=Homo sapiens OX=9606 GN=KLC1 PE=1 SV=2" "0.000" "False" "12.961" "4" "2" "3" "2" "573" "65.3" "6.20" "10.03" "2" "cell adhesion;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00515, Pf13374, Pf13424" "3831" "ENSG00000126214" "KLC1" "A6NF62; F8VTM4; hsa:3831; Q07866; Q7RTM2; Q7RTM3; Q7RTM5; Q7RTP9; Q7RTQ3; Q7RTQ5; Q7RTQ6; Q86SF5; Q86TF5; Q86V74; Q86V75; Q86V76; Q86V77; Q86V78; Q86V79; Q96H62" "Alzheimer's disease and miRNA effects; IL-18 signaling pathway; Alzheimer's disease" "Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1" "8" "0" "1.297" "1.252" "1.268" "1.173" "1.321" "1.198" "1.004" "0.931" "3.775" "96.6" "125.3" "121.0" "122.5" "113.4" "127.6" "115.7" "97.0" "90.0" "364.7" "" "" "" "" "" "" "" "" "" "" "57.8" "65.1" "67.0" "57.5" "52.5" "65.3" "53.8" "43.6" "48.8" "364.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "280272277997118017" "False" "High" "IsMasterProtein" "Q9Y316" "Protein MEMO1 OS=Homo sapiens OX=9606 GN=MEMO1 PE=1 SV=1" "0.000" "False" "12.948" "10" "3" "4" "3" "297" "33.7" "7.14" "13.27" "3" "other biological processes" "" "" "Pf01875" "51072" "ENSG00000162959" "MEMO1" "B4DLS0; D6W575; hsa:51072; Q5R2V8; Q5R2V9; Q6NSL5; Q9Y316" "" "ERBB2 Regulates Cell Motility" "1" "0" "1.208" "1.022" "1.162" "1.101" "1.105" "1.138" "1.087" "1.220" "1.390" "374.2" "452.1" "382.4" "434.6" "412.1" "413.6" "425.9" "406.6" "456.6" "520.1" "" "" "" "" "" "" "" "" "" "" "223.9" "234.9" "211.7" "204.0" "191.0" "211.7" "198.0" "182.5" "247.7" "520.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3968134916858178565" "False" "High" "IsMasterProtein" "P61247" "Small ribosomal subunit protein eS1 OS=Homo sapiens OX=9606 GN=RPS3A PE=1 SV=2" "0.000" "False" "12.934" "18" "4" "4" "4" "264" "29.9" "9.73" "13.24" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01015" "6189" "ENSG00000145425; ENSG00000292158" "RPS3A" "B2R4D4; D3DP05; hsa:6189; P33443; P49241; P61247" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Peptide chain elongation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.901" "0.976" "0.890" "0.869" "1.033" "0.902" "0.971" "0.932" "1.393" "180.2" "162.4" "175.8" "160.3" "156.5" "186.1" "162.5" "175.0" "167.9" "251.0" "" "" "" "" "" "" "" "" "" "" "107.8" "84.4" "97.3" "75.3" "72.5" "95.3" "75.6" "78.6" "91.1" "251.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4936048942270731480" "False" "High" "IsMasterProtein" "O00567" "Nucleolar protein 56 OS=Homo sapiens OX=9606 GN=NOP56 PE=1 SV=4" "0.000" "False" "12.933" "7" "3" "3" "3" "594" "66.0" "9.19" "9.40" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01798, Pf08156" "10528" "ENSG00000101361" "NOP56" "hsa:10528; O00567; Q2M3T6; Q9NQ05" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Association of TriC/CCT with target proteins during biosynthesis" "3" "0" "0.879" "1.130" "0.858" "0.942" "0.829" "0.755" "1.006" "1.112" "0.802" "76.8" "67.5" "86.8" "65.9" "72.3" "63.6" "58.0" "77.3" "85.4" "61.6" "" "" "" "" "" "" "" "" "" "" "46.0" "35.1" "48.1" "30.9" "33.5" "32.6" "27.0" "34.7" "46.3" "61.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3819373703684901703" "False" "High" "IsMasterProtein" "Q2KHT3" "Protein CLEC16A OS=Homo sapiens OX=9606 GN=CLEC16A PE=1 SV=2" "0.000" "False" "12.918" "5" "5" "6" "5" "1053" "117.6" "5.86" "9.34" "5" "other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf09758, Pf19439" "23274" "ENSG00000038532" "CLEC16A" "hsa:23274; O15058; Q2KHT3; Q6ZTB2" "Vitamin D receptor pathway" "" "1" "0" "1.066" "0.797" "1.009" "0.870" "1.052" "0.773" "0.881" "0.886" "0.447" "86.5" "92.2" "69.0" "87.2" "75.2" "91.0" "66.8" "76.2" "76.6" "38.7" "" "" "" "" "" "" "" "" "" "" "51.7" "47.9" "38.2" "41.0" "34.9" "46.6" "31.1" "34.2" "41.6" "38.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3579121838691215902" "False" "High" "IsMasterProtein" "Q7Z6I6" "Rho GTPase-activating protein 30 OS=Homo sapiens OX=9606 GN=ARHGAP30 PE=1 SV=3" "0.000" "False" "12.914" "3" "3" "4" "3" "1101" "118.5" "4.81" "8.90" "3" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00620" "257106" "ENSG00000186517" "ARHGAP30" "hsa:257106; Q5SY52; Q5SY53; Q5SY54; Q6ZML6; Q7Z3J8; Q7Z6I6; Q86XI7" "" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOU GTPase cycle" "4" "0" "0.960" "0.917" "0.976" "0.965" "0.921" "1.157" "1.034" "0.967" "1.435" "131.0" "125.8" "120.1" "127.9" "126.4" "120.6" "151.5" "135.4" "126.7" "188.0" "" "" "" "" "" "" "" "" "" "" "78.4" "65.4" "66.5" "60.0" "58.6" "61.7" "70.5" "60.8" "68.7" "188.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2375435199137725135" "False" "High" "IsMasterProtein" "Q96MH2" "Protein HEXIM2 OS=Homo sapiens OX=9606 GN=HEXIM2 PE=1 SV=1" "0.000" "False" "12.906" "17" "5" "5" "4" "286" "32.4" "6.55" "12.96" "5" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf15313" "124790" "ENSG00000168517" "HEXIM2" "D3DX66; hsa:124790; Q96MH2" "" "" "0" "1" "1.047" "0.905" "0.951" "1.060" "0.993" "1.061" "1.033" "1.023" "0.584" "303.8" "318.1" "274.8" "289.0" "321.9" "301.5" "322.4" "313.7" "310.7" "177.4" "" "" "" "" "" "" "" "" "" "" "181.8" "165.3" "152.2" "135.7" "149.2" "154.4" "149.9" "140.8" "168.6" "177.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8359022296663299879" "False" "High" "IsMasterProtein" "Q14258" "E3 ubiquitin/ISG15 ligase TRIM25 OS=Homo sapiens OX=9606 GN=TRIM25 PE=1 SV=2" "0.000" "False" "12.905" "6" "4" "4" "4" "630" "70.9" "8.09" "10.78" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00622, Pf13445, Pf13765" "7706" "ENSG00000121060" "TRIM25" "hsa:7706; Q14258" "Novel intracellular components of RIG-I-like receptor pathway; Cytosolic DNA-sensing pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; 1p36 copy number variation syndrome" "SARS-CoV-1 activates/modulates innate immune responses; Termination of translesion DNA synthesis; ISG15 antiviral mechanism; Interferon gamma signaling; RSV-host interactions; PKR-mediated signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses" "19" "0" "1.071" "0.982" "1.002" "1.085" "1.169" "1.133" "0.985" "1.087" "4.963" "146.9" "157.3" "144.2" "147.1" "159.3" "171.7" "166.3" "144.6" "159.7" "728.9" "" "" "" "" "" "" "" "" "" "" "87.9" "81.8" "79.8" "69.1" "73.8" "87.9" "77.3" "64.9" "86.6" "728.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5557556089384344895" "False" "High" "IsMasterProtein" "Q9UN86" "Ras GTPase-activating protein-binding protein 2 OS=Homo sapiens OX=9606 GN=G3BP2 PE=1 SV=2" "0.000" "False" "12.884" "11" "5" "8" "5" "482" "54.1" "5.55" "9.81" "5" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02136" "9908" "ENSG00000138757" "G3BP2" "A8K6X1; hsa:9908; O60606; O75149; Q9UN86; Q9UPA1" "" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "1" "0" "1.052" "0.993" "1.013" "1.079" "0.960" "1.140" "0.932" "1.180" "2.016" "217.0" "228.3" "215.5" "219.8" "234.1" "208.4" "247.4" "202.3" "256.0" "437.5" "" "" "" "" "" "" "" "" "" "" "129.9" "118.6" "119.3" "103.2" "108.5" "106.7" "115.0" "90.8" "138.9" "437.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6138498598484703965" "False" "High" "IsMasterProtein" "P30405" "Peptidyl-prolyl cis-trans isomerase F, mitochondrial OS=Homo sapiens OX=9606 GN=PPIF PE=1 SV=1" "0.000" "False" "12.853" "12" "4" "8" "3" "207" "22.0" "9.38" "19.22" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00160" "10105" "ENSG00000108179" "PPIF" "hsa:10105; P30405; Q2YDB7; Q5W131" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "" "2" "0" "1.073" "1.035" "1.045" "1.283" "1.189" "1.076" "1.181" "1.105" "1.388" "562.5" "603.7" "582.3" "588.0" "721.6" "668.6" "605.3" "664.5" "621.4" "780.6" "" "" "" "" "" "" "" "" "" "" "336.6" "313.7" "322.5" "276.1" "334.5" "342.3" "281.4" "298.3" "337.1" "780.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9195295084740601325" "False" "High" "IsMasterProtein" "Q00577" "Transcriptional activator protein Pur-alpha OS=Homo sapiens OX=9606 GN=PURA PE=1 SV=2" "0.000" "False" "12.840" "15" "4" "5" "4" "322" "34.9" "6.44" "10.04" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04845" "5813" "ENSG00000185129" "PURA" "hsa:5813; Q00577" "Exercise-induced circadian regulation" "" "1" "0" "1.016" "0.941" "0.829" "0.881" "1.058" "0.902" "1.061" "1.084" "0.525" "398.1" "404.6" "374.5" "330.0" "350.6" "421.1" "359.1" "422.6" "431.6" "209.0" "" "" "" "" "" "" "" "" "" "" "238.3" "210.2" "207.4" "154.9" "162.5" "215.6" "167.0" "189.7" "234.2" "209.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8144155955974209704" "False" "High" "IsMasterProtein" "P16220" "Cyclic AMP-responsive element-binding protein 1 OS=Homo sapiens OX=9606 GN=CREB1 PE=1 SV=3" "0.000" "False" "12.809" "16" "4" "5" "4" "327" "35.1" "5.27" "14.67" "4" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf02173" "1385" "ENSG00000118260" "CREB1" "hsa:1385; P16220; P21934; Q6V963; Q9UMA7" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; Energy metabolism; miRNAs involved in DNA damage response; Folate-alcohol and cancer pathway hypotheses; Sterol regulatory element-binding proteins (SREBP) signaling; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; MFAP5-mediated ovarian cancer cell motility and invasiveness; Ovarian infertility; MECP2 and associated Rett syndrome; Transcription factor regulation in adipogenesis; BDNF-TrkB signaling; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; p38 MAPK signaling pathway; NO/cGMP/PKG mediated neuroprotection; White fat cell differentiation; PI3K-Akt signaling pathway; Phosphodiesterases in neuronal function; Acute viral myocarditis; Thermogenesis; EGF/EGFR signaling pathway; G1 to S cell cycle control; Fragile X syndrome; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; Hepatitis B infection; Melanoma; mBDNF and proBDNF regulation of GABA neurotransmission; CAMKK2 pathway; GPR143 in melanocytes and retinal pigment epithelium cells; Galanin receptor pathway; Neuroinflammation and glutamatergic signaling; Vasopressin-regulated water reabsorption; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Rubinstein-Taybi syndrome 1; Smith-Magenis and Potocki-Lupski syndrome copy number variation; Interferon type I signaling pathways; T-cell receptor signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling" "HCMV Early Events; FCGR3A-mediated IL10 synthesis; ADORA2B mediated anti-inflammatory cytokines production; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; NGF-stimulated transcription; Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; MECP2 regulates transcription of neuronal ligands; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; Regulation of MECP2 expression and activity; Transcriptional regulation of granulopoiesis; CREB phosphorylation; Gastrin-CREB signalling pathway via PKC and MAPK; NOTCH2 intracellular domain regulates transcription; MECP2 regulates neuronal receptors and channels; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of Adenylate Cyclase; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde; PKA-mediated phosphorylation of CREB; CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling; MECP2 regulates transcription factors" "85" "0" "0.883" "0.908" "0.966" "0.948" "0.882" "1.073" "1.079" "0.880" "0.448" "436.9" "385.6" "396.7" "422.1" "414.0" "385.3" "468.6" "471.5" "384.5" "195.9" "" "" "" "" "" "" "" "" "" "" "261.4" "200.4" "219.7" "198.2" "191.9" "197.2" "217.9" "211.7" "208.6" "195.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8587567595163417034" "False" "High" "IsMasterProtein" "Q9UIQ6" "Leucyl-cystinyl aminopeptidase OS=Homo sapiens OX=9606 GN=LNPEP PE=1 SV=3" "0.000" "False" "12.794" "5" "3" "4" "3" "1025" "117.3" "5.73" "12.76" "3" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "4012" "ENSG00000113441" "LNPEP" "hsa:4012; O00769; Q15145; Q59H76; Q9TNQ2; Q9TNQ3; Q9UIQ6; Q9UIQ7" "" "Antigen processing: Ubiquitination & Proteasome degradation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Endosomal/Vacuolar pathway" "3" "0" "1.224" "1.416" "1.078" "1.495" "1.283" "1.116" "1.457" "1.146" "0.903" "20.2" "24.8" "28.7" "21.8" "30.3" "26.0" "22.6" "29.5" "23.2" "18.3" "" "" "" "" "" "" "" "" "" "" "12.1" "12.9" "15.9" "10.2" "14.0" "13.3" "10.5" "13.2" "12.6" "18.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "385044699666679526" "False" "High" "IsMasterProtein" "P49756" "RNA-binding protein 25 OS=Homo sapiens OX=9606 GN=RBM25 PE=1 SV=3" "0.000" "False" "12.777" "7" "4" "4" "4" "843" "100.1" "6.32" "9.83" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf01480" "58517" "ENSG00000119707" "RBM25" "A0PJL9; B2RNA8; B3KT03; hsa:58517; P49756; Q2TA72; Q5XJ17; Q6P665; Q9H6A1; Q9UEQ5; Q9UIE9" "" "mRNA Splicing - Major Pathway" "1" "0" "1.309" "2.249" "1.774" "2.259" "1.315" "1.416" "1.783" "1.853" "4.349" "15.5" "20.3" "34.9" "27.6" "35.1" "20.4" "22.0" "27.7" "28.8" "67.5" "" "" "" "" "" "" "" "" "" "" "9.3" "10.6" "19.3" "12.9" "16.3" "10.5" "10.2" "12.4" "15.6" "67.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7972522835468462088" "False" "High" "IsMasterProtein" "O43432" "Eukaryotic translation initiation factor 4 gamma 3 OS=Homo sapiens OX=9606 GN=EIF4G3 PE=1 SV=2" "0.000" "False" "12.759" "2" "4" "6" "1" "1585" "176.5" "5.38" "17.13" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf02020, Pf02847, Pf02854" "8672" "ENSG00000075151" "EIF4G3" "B9EGQ7; hsa:8672; O43432; Q15597; Q504Z1; Q5SWC3; Q8NEN1" "Translation factors; Translation inhibitors in chronically activated PDGFRA cells" "ISG15 antiviral mechanism" "3" "0" "1.081" "1.624" "1.510" "1.429" "1.408" "1.405" "2.104" "1.954" "5.864" "9.6" "10.4" "15.6" "14.5" "13.7" "13.5" "13.5" "20.2" "18.7" "56.2" "" "" "" "" "" "" "" "" "" "" "5.7" "5.4" "8.6" "6.8" "6.3" "6.9" "6.3" "9.1" "10.2" "56.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8740518017781001578" "False" "High" "IsMasterProtein" "Q8WW12" "PEST proteolytic signal-containing nuclear protein OS=Homo sapiens OX=9606 GN=PCNP PE=1 SV=2" "0.000" "False" "12.759" "16" "3" "11" "3" "178" "18.9" "7.49" "28.51" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "nucleus" "" "Pf15473" "57092" "ENSG00000081154" "PCNP" "B2RBE7; D3DN52; hsa:57092; Q53GF3; Q6AI44; Q8WW12; Q96CU3; Q9NS81" "" "" "0" "0" "0.935" "0.953" "0.960" "1.122" "1.061" "1.064" "1.054" "0.907" "0.623" "860.0" "804.1" "819.9" "825.3" "965.2" "912.5" "914.7" "906.7" "780.2" "536.1" "" "" "" "" "" "" "" "" "" "" "514.7" "417.8" "454.0" "387.4" "447.4" "467.2" "425.3" "407.1" "423.3" "536.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7768622532908684431" "False" "High" "IsMasterProtein" "P26842" "CD27 antigen OS=Homo sapiens OX=9606 GN=CD27 PE=1 SV=2" "0.000" "False" "12.758" "14" "3" "7" "3" "260" "29.1" "7.64" "20.32" "3" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "enzyme regulator activity;other molecular function" "Pf00020" "939" "ENSG00000139193" "CD27" "B2RDZ0; hsa:939; P26842" "" "TNFs bind their physiological receptors" "1" "0" "0.947" "1.031" "1.019" "1.061" "1.059" "1.027" "1.072" "1.044" "0.578" "437.8" "414.6" "451.6" "446.2" "464.6" "463.8" "449.5" "469.2" "457.0" "253.1" "" "" "" "" "" "" "" "" "" "" "262.0" "215.4" "250.1" "209.5" "215.4" "237.4" "209.0" "210.6" "247.9" "253.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1822360151641721881" "False" "High" "IsMasterProtein" "Q9NP81" "Serine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=SARS2 PE=1 SV=1" "0.000" "False" "12.751" "9" "5" "5" "5" "518" "58.2" "8.13" "14.32" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00587" "54938" "ENSG00000104835; ENSG00000283104" "SARS2" "A6NHW7; B4DE10; hsa:54938; Q9BVP3; Q9NP81" "Selenium metabolism and selenoproteins" "Mitochondrial tRNA aminoacylation" "2" "0" "1.055" "1.115" "1.250" "1.026" "1.061" "1.147" "1.056" "1.005" "0.937" "143.6" "151.5" "160.2" "179.6" "147.3" "152.4" "164.7" "151.7" "144.4" "134.6" "" "" "" "" "" "" "" "" "" "" "86.0" "78.7" "88.7" "84.3" "68.3" "78.0" "76.6" "68.1" "78.4" "134.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6990414283188081585" "False" "High" "IsMasterProtein" "O43660" "Pleiotropic regulator 1 OS=Homo sapiens OX=9606 GN=PLRG1 PE=1 SV=1" "0.000" "False" "12.737" "9" "4" "4" "4" "514" "57.2" "9.17" "11.45" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "" "Pf00400" "5356" "ENSG00000171566" "PLRG1" "B3KMK4; hsa:5356; O43660; Q3KQY5; Q8WUD8" "" "mRNA Splicing - Major Pathway" "1" "0" "0.851" "0.974" "0.907" "0.964" "0.840" "0.930" "0.856" "1.116" "0.865" "224.9" "191.4" "219.0" "204.0" "216.9" "188.8" "209.1" "192.5" "250.9" "194.7" "" "" "" "" "" "" "" "" "" "" "134.6" "99.5" "121.3" "95.8" "100.5" "96.7" "97.2" "86.4" "136.1" "194.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5145837311521029190" "False" "High" "IsMasterProtein" "Q8N183" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 OS=Homo sapiens OX=9606 GN=NDUFAF2 PE=1 SV=1" "0.000" "False" "12.728" "17" "3" "6" "3" "169" "19.8" "8.97" "15.25" "3" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf05071" "91942" "ENSG00000164182" "NDUFAF2" "A8K5I1; hsa:91942; Q8N183" "SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "Complex I biogenesis" "2" "0" "0.913" "0.918" "1.006" "1.133" "0.938" "0.805" "1.076" "0.879" "0.274" "112.2" "102.4" "103.0" "112.9" "127.2" "105.3" "90.4" "120.8" "98.7" "30.8" "" "" "" "" "" "" "" "" "" "" "67.2" "53.2" "57.0" "53.0" "59.0" "53.9" "42.0" "54.2" "53.5" "30.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2783720911668015522" "False" "High" "IsMasterProtein" "Q9NWT6" "Hypoxia-inducible factor 1-alpha inhibitor OS=Homo sapiens OX=9606 GN=HIF1AN PE=1 SV=2" "0.000" "False" "12.725" "10" "3" "4" "3" "349" "40.3" "5.57" "10.78" "3" "other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13621" "55662" "ENSG00000166135" "HIF1AN" "D3DR69; hsa:55662; Q5W147; Q969Q7; Q9NPV5; Q9NWT6" "MicroRNA for targeting cancer growth and vascularization in glioblastoma; Photodynamic therapy-induced HIF-1 survival signaling" "Cellular response to hypoxia" "3" "0" "0.931" "0.959" "1.024" "0.999" "1.030" "0.950" "1.069" "1.114" "0.883" "164.7" "153.3" "157.9" "168.7" "164.5" "169.6" "156.5" "176.1" "183.4" "145.5" "" "" "" "" "" "" "" "" "" "" "98.6" "79.7" "87.4" "79.2" "76.2" "86.8" "72.8" "79.1" "99.5" "145.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8696690186535498755" "False" "High" "IsMasterProtein" "Q9NPJ3" "Acyl-coenzyme A thioesterase 13 OS=Homo sapiens OX=9606 GN=ACOT13 PE=1 SV=1" "0.000" "False" "12.713" "16" "2" "18" "2" "140" "15.0" "9.14" "45.40" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion" "other molecular function" "Pf03061" "55856" "ENSG00000112304" "ACOT13" "F5H2L4; hsa:55856; O95549; Q9NPJ3" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "0.998" "1.054" "1.042" "0.979" "1.106" "0.937" "1.112" "0.956" "0.572" "765.8" "764.2" "806.9" "798.1" "749.8" "847.1" "717.7" "851.3" "732.3" "437.8" "" "" "" "" "" "" "" "" "" "" "458.3" "397.1" "446.8" "374.7" "347.5" "433.6" "333.7" "382.2" "397.3" "437.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6567734872650185245" "False" "High" "IsMasterProtein" "C9JLW8" "Mapk-regulated corepressor-interacting protein 1 OS=Homo sapiens OX=9606 GN=MCRIP1 PE=1 SV=1" "0.000" "False" "12.705" "28" "2" "7" "2" "97" "10.9" "9.41" "18.42" "2" "other biological processes" "nucleus;other cell component" "" "Pf14799" "348262" "ENSG00000225663; ENSG00000288213" "MCRIP1" "C9JLW8; hsa:348262; Q6ZUL0" "" "" "0" "0" "1.007" "1.029" "1.004" "1.010" "1.036" "1.054" "0.990" "1.012" "1.669" "242.0" "243.6" "248.9" "242.9" "244.4" "250.6" "254.9" "239.6" "244.9" "403.9" "" "" "" "" "" "" "" "" "" "" "144.8" "126.6" "137.9" "114.1" "113.3" "128.3" "118.5" "107.6" "132.9" "403.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-768881656379736442" "False" "High" "IsMasterProtein" "Q9BT73" "Proteasome assembly chaperone 3 OS=Homo sapiens OX=9606 GN=PSMG3 PE=1 SV=1" "0.000" "False" "12.686" "23" "2" "5" "2" "122" "13.1" "7.88" "16.03" "2" "cell organization and biogenesis" "other cell component" "other molecular function" "Pf10178" "84262" "ENSG00000157778" "PSMG3" "A4D216; A8MPW2; hsa:84262; Q9BT73" "" "" "0" "0" "0.965" "1.038" "0.915" "0.891" "0.990" "1.045" "1.023" "0.896" "0.754" "119.8" "115.6" "124.3" "109.6" "106.7" "118.6" "125.2" "122.5" "107.4" "90.4" "" "" "" "" "" "" "" "" "" "" "71.7" "60.1" "68.8" "51.5" "49.5" "60.7" "58.2" "55.0" "58.3" "90.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5470294891726501754" "False" "High" "IsMasterProtein" "P61962" "DDB1- and CUL4-associated factor 7 OS=Homo sapiens OX=9606 GN=DCAF7 PE=1 SV=1" "0.000" "False" "12.677" "13" "5" "5" "5" "342" "38.9" "5.52" "13.51" "5" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "10238" "ENSG00000136485" "DCAF7" "B4E039; D3DU14; hsa:10238; O15491; P61962; Q9DAE4" "Ciliary landscape; DYRK1A involvement regarding cell proliferation in brain development" "Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "4" "0" "0.964" "0.932" "1.006" "1.018" "1.090" "0.951" "1.021" "1.080" "1.278" "390.5" "376.5" "363.9" "393.0" "397.6" "425.5" "371.2" "398.5" "421.8" "498.9" "" "" "" "" "" "" "" "" "" "" "233.7" "195.7" "201.5" "184.5" "184.3" "217.8" "172.6" "178.9" "228.9" "498.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4118942694403519746" "False" "High" "IsMasterProtein" "Q13492" "Phosphatidylinositol-binding clathrin assembly protein OS=Homo sapiens OX=9606 GN=PICALM PE=1 SV=2" "0.000" "False" "12.672" "6" "4" "4" "4" "652" "70.7" "7.90" "9.31" "4" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf07651" "8301" "ENSG00000073921" "PICALM" "B4DTM3; E9PN05; F8VPG7; hsa:8301; O60700; Q13492; Q4LE54; Q6GMQ6; Q86XZ9" "" "Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; RND3 GTPase cycle" "4" "0" "1.381" "1.085" "1.233" "1.106" "1.375" "1.295" "1.182" "1.289" "0.884" "96.5" "133.3" "104.7" "119.0" "106.8" "132.7" "125.0" "114.0" "124.4" "85.3" "" "" "" "" "" "" "" "" "" "" "57.7" "69.3" "58.0" "55.9" "49.5" "67.9" "58.1" "51.2" "67.5" "85.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5034217840069919209" "False" "High" "IsMasterProtein" "O95721" "Synaptosomal-associated protein 29 OS=Homo sapiens OX=9606 GN=SNAP29 PE=1 SV=1" "0.000" "False" "12.649" "12" "3" "4" "3" "258" "29.0" "5.81" "14.38" "3" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "" "9342" "ENSG00000099940" "SNAP29" "hsa:9342; O95721" "Ciliary landscape; 22q11.2 copy number variation syndrome" "Neutrophil degranulation; Intra-Golgi traffic" "4" "0" "1.324" "0.994" "1.042" "1.462" "1.141" "1.445" "1.077" "1.136" "0.541" "45.2" "59.8" "44.9" "47.1" "66.1" "51.6" "65.3" "48.7" "51.3" "24.4" "" "" "" "" "" "" "" "" "" "" "27.1" "31.1" "24.9" "22.1" "30.6" "26.4" "30.4" "21.9" "27.8" "24.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8095037981369694658" "False" "High" "IsMasterProtein" "P52434" "DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens OX=9606 GN=POLR2H PE=1 SV=4" "0.000" "False" "12.617" "13" "2" "4" "2" "150" "17.1" "4.68" "12.75" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03870" "5437" "ENSG00000163882" "POLR2H" "C9J413; C9JBJ6; C9JCU7; C9JUA8; hsa:5437; P52434; P53802; Q969R0" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "mRNA Splicing - Major Pathway; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Abortive elongation of HIV-1 transcript in the absence of Tat; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "57" "0" "1.099" "1.287" "1.016" "1.144" "1.001" "0.922" "0.780" "1.108" "3.024" "137.7" "151.3" "177.2" "139.9" "157.5" "137.8" "127.0" "107.4" "152.6" "416.5" "" "" "" "" "" "" "" "" "" "" "82.4" "78.6" "98.1" "65.7" "73.0" "70.6" "59.1" "48.2" "82.8" "416.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5023759696218809409" "False" "High" "IsMasterProtein" "Q7Z434" "Mitochondrial antiviral-signaling protein OS=Homo sapiens OX=9606 GN=MAVS PE=1 SV=2" "0.000" "False" "12.587" "12" "4" "4" "4" "540" "56.5" "5.52" "8.46" "4" "stress response;signal transduction;other biological processes" "other membranes;mitochondrion;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf16739" "57506" "ENSG00000088888" "MAVS" "A8K6X0; B2BD33; B2BD34; F5H6C8; hsa:57506; M1P2Z0; Q2HWT5; Q3I0Y2; Q5T7I6; Q7Z434; Q86VY7; Q9H1H3; Q9H4Y1; Q9H8D3; Q9ULE9" "Novel intracellular components of RIG-I-like receptor pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "PKR-mediated signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Negative regulators of DDX58/IFIH1 signaling; SARS-CoV-1 activates/modulates innate immune responses; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses" "24" "0" "0.847" "1.114" "1.074" "1.114" "0.971" "1.078" "1.172" "1.036" "0.708" "81.2" "68.8" "90.5" "87.2" "90.5" "78.9" "87.6" "95.2" "84.2" "57.5" "" "" "" "" "" "" "" "" "" "" "48.6" "35.8" "50.1" "40.9" "41.9" "40.4" "40.7" "42.7" "45.7" "57.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5532813342924820659" "False" "High" "IsMasterProtein" "Q9Y383" "Putative RNA-binding protein Luc7-like 2 OS=Homo sapiens OX=9606 GN=LUC7L2 PE=1 SV=2" "0.000" "False" "12.578" "12" "5" "5" "5" "392" "46.5" "10.01" "13.98" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03194" "51631" "ENSG00000146963" "LUC7L2" "B7Z500; hsa:51631; Q8IUP9; Q9NVL3; Q9NVN7; Q9UQN1; Q9Y383" "" "" "0" "0" "1.044" "1.148" "0.932" "1.097" "1.045" "1.011" "0.815" "1.207" "2.785" "225.1" "235.1" "258.5" "209.8" "247.0" "235.2" "227.7" "183.6" "271.8" "626.9" "" "" "" "" "" "" "" "" "" "" "134.7" "122.1" "143.2" "98.5" "114.5" "120.4" "105.9" "82.4" "147.5" "626.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4459716120349710015" "False" "High" "IsMasterProtein" "O14545" "TRAF-type zinc finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=TRAFD1 PE=1 SV=1" "0.000" "False" "12.569" "6" "3" "3" "3" "582" "64.8" "5.29" "6.51" "3" "other biological processes" "mitochondrion" "other molecular function" "Pf21366" "10906" "ENSG00000135148" "TRAFD1" "A8K5L6; B4DI89; hsa:10906; O14545" "" "" "0" "0" "0.712" "0.667" "1.123" "0.623" "0.871" "1.198" "1.053" "0.740" "0.377" "36.0" "25.6" "24.0" "40.4" "22.4" "31.3" "43.1" "37.9" "26.6" "13.6" "" "" "" "" "" "" "" "" "" "" "21.5" "13.3" "13.3" "19.0" "10.4" "16.0" "20.0" "17.0" "14.4" "13.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7107318601171383488" "False" "High" "IsMasterProtein" "Q9Y3C8" "Ubiquitin-fold modifier-conjugating enzyme 1 OS=Homo sapiens OX=9606 GN=UFC1 PE=1 SV=3" "0.000" "False" "12.566" "19" "4" "7" "4" "167" "19.4" "7.40" "20.21" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes" "" "other molecular function" "Pf08694" "51506" "ENSG00000143222" "UFC1" "A8K9R1; D3DVF9; hsa:51506; Q549X0; Q5VTX1; Q9BS96; Q9P009; Q9Y3C8" "" "" "0" "0" "1.102" "1.043" "1.002" "1.156" "1.102" "0.941" "1.035" "1.054" "0.649" "481.3" "530.3" "501.8" "482.4" "556.5" "530.2" "452.8" "498.1" "507.4" "312.4" "" "" "" "" "" "" "" "" "" "" "288.0" "275.6" "277.9" "226.5" "258.0" "271.4" "210.5" "223.6" "275.3" "312.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832303337719112949" "False" "High" "IsMasterProtein" "Q15154" "Pericentriolar material 1 protein OS=Homo sapiens OX=9606 GN=PCM1 PE=1 SV=6" "0.000" "False" "12.564" "1" "3" "3" "3" "2024" "228.4" "5.02" "10.14" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15717" "5108" "ENSG00000078674" "PCM1" "A6NNN6; B4DYD5; E7ETA6; E7EV56; hsa:5108; Q15154; Q58F13; Q6P1K7; Q8NB85; Q9BWC1; Q9H4A2" "Prader-Willi and Angelman syndrome; Joubert syndrome" "Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "9" "0" "1.113" "0.982" "0.954" "1.064" "0.942" "1.173" "1.097" "1.091" "0.879" "254.4" "283.1" "249.9" "242.7" "270.7" "239.6" "298.4" "279.1" "277.5" "223.6" "" "" "" "" "" "" "" "" "" "" "152.3" "147.1" "138.4" "113.9" "125.5" "122.7" "138.7" "125.3" "150.5" "223.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2753763641550930270" "False" "High" "IsMasterProtein" "Q96NB3" "Zinc finger protein 830 OS=Homo sapiens OX=9606 GN=ZNF830 PE=1 SV=2" "0.000" "False" "12.553" "10" "3" "5" "3" "372" "42.0" "5.31" "10.67" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12874" "91603" "ENSG00000198783" "ZNF830" "hsa:91603; Q96F60; Q96GZ5; Q96NB3; Q9BU38" "17q12 copy number variation syndrome" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "6" "0" "0.912" "0.917" "0.977" "1.133" "0.983" "1.052" "1.167" "0.961" "0.422" "261.9" "238.8" "240.1" "255.8" "296.8" "257.4" "275.4" "305.7" "251.7" "110.5" "" "" "" "" "" "" "" "" "" "" "156.7" "124.1" "133.0" "120.1" "137.6" "131.7" "128.1" "137.2" "136.5" "110.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3246140782840633700" "False" "High" "IsMasterProtein" "Q96B01" "RAD51-associated protein 1 OS=Homo sapiens OX=9606 GN=RAD51AP1 PE=1 SV=1" "0.000" "False" "12.550" "9" "3" "4" "3" "352" "38.4" "9.11" "8.93" "3" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf15696" "10635" "ENSG00000111247" "RAD51AP1" "A8K7D3; hsa:10635; O43403; Q7Z779; Q96B01" "" "Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange; Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2" "8" "0" "1.148" "1.107" "1.037" "1.226" "1.281" "1.191" "1.345" "1.327" "0.625" "184.1" "211.4" "203.8" "190.9" "225.8" "235.8" "219.4" "247.7" "244.3" "115.1" "" "" "" "" "" "" "" "" "" "" "110.2" "109.8" "112.9" "89.6" "104.7" "120.7" "102.0" "111.2" "132.5" "115.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-486365272632798294" "False" "High" "IsMasterProtein" "Q8WUW1" "Protein BRICK1 OS=Homo sapiens OX=9606 GN=BRK1 PE=1 SV=1" "0.000" "False" "12.545" "63" "5" "9" "5" "75" "8.7" "5.45" "19.32" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "" "55845" "ENSG00000254999" "BRK1" "B2R5E2; hsa:55845; Q8WUW1; Q9P082" "Regulation of actin cytoskeleton" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "8" "0" "1.064" "1.013" "1.001" "1.151" "1.022" "1.259" "1.005" "1.108" "1.440" "440.9" "468.9" "446.6" "441.4" "507.4" "450.4" "555.1" "443.2" "488.5" "635.0" "" "" "" "" "" "" "" "" "" "" "263.9" "243.7" "247.3" "207.2" "235.2" "230.6" "258.1" "199.0" "265.1" "635.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3197858597980699967" "False" "High" "IsMasterProtein" "Q9HA64" "Ketosamine-3-kinase OS=Homo sapiens OX=9606 GN=FN3KRP PE=1 SV=2" "0.000" "False" "12.518" "13" "3" "3" "3" "309" "34.4" "7.33" "8.83" "3" "protein metabolism;other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf03881" "79672" "ENSG00000141560" "FN3KRP" "hsa:79672; Q969F4; Q9H0U7; Q9HA64" "" "Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation" "1" "0" "1.349" "1.395" "1.111" "1.274" "1.145" "1.321" "1.241" "1.231" "0.634" "52.0" "70.2" "72.6" "57.8" "66.3" "59.6" "68.7" "64.6" "64.1" "33.0" "" "" "" "" "" "" "" "" "" "" "31.1" "36.5" "40.2" "27.1" "30.7" "30.5" "31.9" "29.0" "34.8" "33.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2614245215378921803" "False" "High" "IsMasterProtein" "Q9UBU8" "Mortality factor 4-like protein 1 OS=Homo sapiens OX=9606 GN=MORF4L1 PE=1 SV=2" "0.000" "False" "12.505" "12" "4" "4" "4" "362" "41.4" "9.28" "10.27" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05712, Pf11717" "10933" "ENSG00000185787" "MORF4L1" "B4DKN6; B7Z6R1; D3DW88; hsa:10933; O95899; Q5QTS1; Q6NVX8; Q86YT7; Q9HBP6; Q9NSW5; Q9UBU8" "Pathways affected in adenoid cystic carcinoma" "HATs acetylate histones" "2" "0" "0.874" "0.925" "1.020" "1.010" "0.950" "1.214" "0.874" "0.939" "2.204" "95.8" "83.7" "88.6" "97.7" "96.7" "91.0" "116.3" "83.7" "89.9" "211.1" "" "" "" "" "" "" "" "" "" "" "57.3" "43.5" "49.1" "45.9" "44.8" "46.6" "54.1" "37.6" "48.8" "211.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2128989799875943394" "False" "High" "IsMasterProtein" "Q92888" "Rho guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=ARHGEF1 PE=1 SV=2" "0.000" "False" "12.485" "6" "5" "5" "5" "912" "102.4" "5.66" "9.40" "5" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf00621, Pf09128, Pf17838" "9138" "ENSG00000076928" "ARHGEF1" "hsa:9138; O00513; Q6NX52; Q8N4J4; Q92888; Q96BF4; Q96F17; Q9BSB1" "G protein signaling pathways; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "RHOA GTPase cycle; RHOC GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle" "9" "0" "1.119" "1.068" "1.224" "1.154" "1.051" "1.100" "0.967" "0.998" "4.381" "58.3" "65.3" "62.3" "71.4" "67.3" "61.3" "64.2" "56.4" "58.2" "255.6" "" "" "" "" "" "" "" "" "" "" "34.9" "33.9" "34.5" "33.5" "31.2" "31.4" "29.8" "25.3" "31.6" "255.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8357658854123366068" "False" "High" "IsMasterProtein" "O00629" "Importin subunit alpha-3 OS=Homo sapiens OX=9606 GN=KPNA4 PE=1 SV=1" "0.000" "False" "12.483" "6" "3" "9" "2" "521" "57.9" "4.96" "19.25" "3" "cell-cell signaling;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3840" "ENSG00000186432" "KPNA4" "A8K4S6; D3DNM2; hsa:3840; O00190; O00629" "Leptin signaling pathway" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways" "3" "0" "0.958" "0.621" "0.875" "0.972" "0.689" "0.588" "0.532" "0.652" "1.430" "25.9" "24.8" "16.1" "22.6" "25.2" "17.8" "15.2" "13.8" "16.9" "37.0" "" "" "" "" "" "" "" "" "" "" "15.5" "12.9" "8.9" "10.6" "11.7" "9.1" "7.1" "6.2" "9.2" "37.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5921429182500705176" "False" "High" "IsMasterProtein" "O43765" "Small glutamine-rich tetratricopeptide repeat-containing protein alpha OS=Homo sapiens OX=9606 GN=SGTA PE=1 SV=1" "0.000" "False" "12.475" "14" "4" "8" "4" "313" "34.0" "4.87" "9.01" "4" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00515, Pf13181, Pf16546" "6449" "ENSG00000104969" "SGTA" "D6W610; hsa:6449; O43765; Q6FIA9; Q9BTZ9" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "1.402" "1.773" "1.816" "1.698" "1.039" "1.638" "1.055" "1.726" "3.643" "14.5" "20.3" "25.7" "26.3" "24.6" "15.1" "23.7" "15.3" "25.0" "52.8" "" "" "" "" "" "" "" "" "" "" "8.7" "10.6" "14.2" "12.4" "11.4" "7.7" "11.0" "6.9" "13.6" "52.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8295272483259113664" "False" "High" "IsMasterProtein" "Q9Y333" "U6 snRNA-associated Sm-like protein LSm2 OS=Homo sapiens OX=9606 GN=LSM2 PE=1 SV=1" "0.000" "False" "12.469" "40" "3" "10" "3" "95" "10.8" "6.52" "19.78" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "57819" "ENSG00000172850; ENSG00000204392; ENSG00000224979; ENSG00000225998; ENSG00000231502; ENSG00000236826" "LSM2" "hsa:57819; Q6FGG1; Q9Y333" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "3" "0" "1.034" "1.028" "1.061" "1.108" "1.200" "0.906" "1.247" "1.056" "0.720" "673.9" "696.7" "692.8" "715.1" "746.9" "808.7" "610.4" "840.2" "711.6" "485.5" "" "" "" "" "" "" "" "" "" "" "403.3" "362.0" "383.6" "335.7" "346.2" "414.0" "283.8" "377.2" "386.1" "485.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-476306151852591039" "False" "High" "IsMasterProtein" "Q15102" "Platelet-activating factor acetylhydrolase IB subunit alpha1 OS=Homo sapiens OX=9606 GN=PAFAH1B3 PE=1 SV=1" "0.000" "False" "12.467" "15" "4" "11" "4" "231" "25.7" "6.84" "24.96" "4" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13472" "5050" "ENSG00000079462" "PAFAH1B3" "hsa:5050; Q15102; Q53X88" "PAFAH1B1 copy number variation" "COPI-independent Golgi-to-ER retrograde traffic" "2" "0" "0.991" "0.976" "1.195" "1.185" "1.041" "1.223" "0.989" "1.203" "3.376" "224.6" "222.7" "219.2" "268.4" "266.3" "233.8" "274.8" "222.1" "270.2" "758.4" "" "" "" "" "" "" "" "" "" "" "134.4" "115.7" "121.4" "126.0" "123.4" "119.7" "127.8" "99.7" "146.6" "758.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1739284738644474323" "False" "High" "IsMasterProtein" "P25098" "Beta-adrenergic receptor kinase 1 OS=Homo sapiens OX=9606 GN=GRK2 PE=1 SV=2" "0.000" "False" "12.459" "6" "5" "7" "5" "689" "79.5" "7.28" "14.05" "5" "cell-cell signaling;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00615" "156" "ENSG00000173020" "GRK2" "B0ZBE1; hsa:156; P25098; Q13837; Q6GTT3" "Chemokine signaling pathway; Hedgehog signaling pathway; Hedgehog signaling pathway; HDAC6 interactions in the central nervous system" "Cargo recognition for clathrin-mediated endocytosis; G alpha (q) signalling events; Activation of SMO; G alpha (s) signalling events; Calmodulin induced events" "9" "0" "1.135" "1.003" "1.149" "1.111" "1.185" "1.154" "1.143" "1.183" "1.395" "257.6" "292.3" "258.3" "295.9" "286.3" "305.2" "297.2" "294.4" "304.7" "359.3" "" "" "" "" "" "" "" "" "" "" "154.2" "151.9" "143.0" "138.9" "132.7" "156.2" "138.2" "132.2" "165.3" "359.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6048249212605468111" "False" "High" "IsMasterProtein" "P30876" "DNA-directed RNA polymerase II subunit RPB2 OS=Homo sapiens OX=9606 GN=POLR2B PE=1 SV=1" "0.000" "False" "12.458" "4" "4" "4" "4" "1174" "133.8" "6.87" "11.31" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04566, Pf04567" "5431" "ENSG00000047315" "POLR2B" "A8K1A8; hsa:5431; P30876; Q8IZ61" "Pyrimidine metabolism; Eukaryotic transcription initiation" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "43" "0" "1.005" "0.836" "0.891" "0.878" "0.933" "1.000" "0.835" "0.932" "2.175" "80.3" "80.7" "67.1" "71.5" "70.5" "74.9" "80.3" "67.0" "74.8" "174.5" "" "" "" "" "" "" "" "" "" "" "48.0" "41.9" "37.2" "33.6" "32.7" "38.3" "37.3" "30.1" "40.6" "174.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1135638411849566769" "False" "High" "IsMasterProtein" "O76021" "Ribosomal L1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RSL1D1 PE=1 SV=3" "0.000" "False" "12.441" "9" "5" "5" "5" "490" "54.9" "10.13" "12.16" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf00687" "26156" "ENSG00000171490" "RSL1D1" "B4DJ58; D3DUG7; hsa:26156; O76021; Q2M1T7; Q6PL22; Q8IWS7; Q8WUZ1; Q9HDA9; Q9Y3Z9" "" "" "0" "0" "0.990" "1.018" "0.764" "1.006" "0.897" "0.836" "0.934" "0.975" "1.123" "104.7" "103.6" "106.5" "80.0" "105.3" "93.9" "87.5" "97.8" "102.1" "117.5" "" "" "" "" "" "" "" "" "" "" "62.6" "53.8" "59.0" "37.6" "48.8" "48.1" "40.7" "43.9" "55.4" "117.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3312961601966625911" "False" "High" "IsMasterProtein" "Q96EY8" "Corrinoid adenosyltransferase MMAB OS=Homo sapiens OX=9606 GN=MMAB PE=1 SV=1" "0.000" "False" "12.417" "14" "3" "4" "3" "250" "27.4" "8.60" "12.24" "3" "other metabolic processes" "mitochondrion" "other molecular function" "Pf01923" "326625" "ENSG00000139428" "MMAB" "C5HU05; hsa:326625; Q96EY8; Q9BSH0" "Vitamin B12 metabolism" "Cobalamin (Cbl) metabolism; Defective MMAB causes MMA, cblB type" "3" "0" "1.075" "1.014" "0.939" "1.089" "1.063" "1.129" "1.022" "1.064" "0.835" "399.9" "430.0" "405.5" "375.4" "435.3" "425.2" "451.7" "408.8" "425.6" "333.8" "" "" "" "" "" "" "" "" "" "" "239.3" "223.5" "224.5" "176.2" "201.8" "217.7" "210.0" "183.5" "230.9" "333.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4107495286689168051" "False" "High" "IsMasterProtein" "P42566" "Epidermal growth factor receptor substrate 15 OS=Homo sapiens OX=9606 GN=EPS15 PE=1 SV=2" "0.000" "False" "12.381" "4" "4" "4" "4" "896" "98.6" "4.64" "10.83" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "" "2060" "ENSG00000085832" "EPS15" "B2R8J7; D3DPJ2; hsa:2060; P42566; Q5SRH4" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; EGF/EGFR signaling pathway" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "8" "0" "1.229" "1.277" "1.369" "1.168" "1.160" "1.264" "1.230" "1.558" "2.136" "278.8" "342.5" "355.9" "381.6" "325.6" "323.5" "352.4" "343.1" "434.5" "595.7" "" "" "" "" "" "" "" "" "" "" "166.9" "178.0" "197.1" "179.2" "150.9" "165.6" "163.9" "154.0" "235.7" "595.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5585340363182511889" "False" "High" "IsMasterProtein" "Q9HBU6" "Ethanolamine kinase 1 OS=Homo sapiens OX=9606 GN=ETNK1 PE=1 SV=1" "0.000" "False" "12.366" "6" "4" "5" "4" "452" "50.9" "6.54" "13.30" "4" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01633" "55500" "ENSG00000139163" "ETNK1" "G5E969; hsa:55500; Q9HBU6" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids" "Synthesis of PE" "5" "0" "1.197" "1.073" "1.185" "0.976" "1.211" "1.256" "1.488" "1.317" "1.317" "142.2" "170.2" "152.6" "168.4" "138.7" "172.3" "178.6" "211.6" "187.2" "187.2" "" "" "" "" "" "" "" "" "" "" "85.1" "88.4" "84.5" "79.1" "64.3" "88.2" "83.0" "95.0" "101.6" "187.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5702774175857427246" "False" "High" "IsMasterProtein" "Q02078" "Myocyte-specific enhancer factor 2A OS=Homo sapiens OX=9606 GN=MEF2A PE=1 SV=1" "0.000" "False" "12.301" "8" "3" "5" "1" "507" "54.8" "7.91" "12.41" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4205" "ENSG00000068305" "MEF2A" "B4DFQ7; F6XG23; hsa:4205; O43814; Q02078; Q14223; Q14224; Q59GX4; Q7Z6C9; Q96D14" "Energy metabolism; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; TGF-beta signaling pathway; EGF/EGFR signaling pathway; IL-18 signaling pathway; 2q37 copy number variation syndrome" "Myogenesis; ERK/MAPK targets" "13" "0" "0.900" "0.994" "1.133" "1.487" "1.032" "1.353" "1.279" "1.131" "1.064" "20.5" "18.5" "20.4" "23.3" "30.6" "21.2" "27.8" "26.3" "23.2" "21.9" "" "" "" "" "" "" "" "" "" "" "12.3" "9.6" "11.3" "10.9" "14.2" "10.9" "12.9" "11.8" "12.6" "21.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "841386405994122390" "False" "High" "IsMasterProtein" "Q92785" "Zinc finger protein ubi-d4 OS=Homo sapiens OX=9606 GN=DPF2 PE=1 SV=2" "0.000" "False" "12.299" "9" "3" "4" "3" "391" "44.1" "6.33" "7.67" "3" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00628, Pf14051" "5977" "ENSG00000133884" "DPF2" "A8K7C9; B4DT58; hsa:5977; Q92785" "Tumor suppressor activity of SMARCB1" "" "1" "0" "0.930" "0.907" "1.020" "1.004" "0.930" "0.927" "0.939" "0.961" "1.056" "62.4" "58.0" "56.6" "63.6" "62.6" "58.0" "57.9" "58.6" "60.0" "65.9" "" "" "" "" "" "" "" "" "" "" "37.3" "30.1" "31.3" "29.9" "29.0" "29.7" "26.9" "26.3" "32.5" "65.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1761615694951134021" "False" "High" "IsMasterProtein" "P62888" "Large ribosomal subunit protein eL30 OS=Homo sapiens OX=9606 GN=RPL30 PE=1 SV=2" "0.000" "False" "12.297" "31" "3" "6" "3" "115" "12.8" "9.63" "11.53" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6156" "ENSG00000156482" "RPL30" "B2R591; hsa:6156; P04645; P62888; Q502Z6" "Selenium metabolism and selenoproteins; Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.007" "1.210" "0.990" "0.713" "0.966" "0.911" "0.896" "1.116" "0.955" "70.0" "70.5" "84.7" "69.3" "49.9" "67.6" "63.8" "62.8" "78.1" "66.8" "" "" "" "" "" "" "" "" "" "" "41.9" "36.7" "46.9" "32.5" "23.1" "34.6" "29.7" "28.2" "42.4" "66.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6901270763620924094" "False" "High" "IsMasterProtein" "Q6P1N9" "Deoxyribonuclease TATDN1 OS=Homo sapiens OX=9606 GN=TATDN1 PE=1 SV=2" "0.000" "False" "12.294" "12" "4" "6" "4" "297" "33.6" "6.96" "12.18" "4" "DNA metabolism" "nucleus" "other molecular function" "Pf01026" "83940" "ENSG00000147687; ENSG00000291730" "TATDN1" "B2R5J0; hsa:83940; Q6P1N9; Q8TD02; Q9BY40" "" "" "0" "0" "0.919" "0.944" "0.907" "0.752" "0.955" "1.064" "0.909" "0.842" "0.701" "58.5" "53.8" "55.2" "53.1" "44.0" "55.9" "62.2" "53.2" "49.3" "41.0" "" "" "" "" "" "" "" "" "" "" "35.0" "27.9" "30.6" "24.9" "20.4" "28.6" "28.9" "23.9" "26.7" "41.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4828769571271312822" "False" "High" "IsMasterProtein" "P46108" "Adapter molecule crk OS=Homo sapiens OX=9606 GN=CRK PE=1 SV=2" "0.000" "False" "12.282" "11" "3" "3" "3" "304" "33.8" "5.55" "9.51" "3" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00017, Pf00018, Pf07653" "1398" "ENSG00000167193" "CRK" "A8MWE8; B0LPE8; D3DTH6; hsa:1398; P46108; Q96GA9; Q96HJ0" "Integrin-mediated cell adhesion; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Rett syndrome; EGF/EGFR signaling pathway; Gastrin signaling pathway; Insulin signaling; Regulation of actin cytoskeleton; GDNF signaling; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "FCGR3A-mediated phagocytosis; Regulation of signaling by CBL; Regulation of actin dynamics for phagocytic cup formation; Downstream signal transduction; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; ARMS-mediated activation; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1; MET receptor recycling" "31" "0" "0.983" "1.179" "1.051" "1.038" "0.982" "0.975" "0.821" "1.040" "2.432" "174.3" "171.4" "205.5" "183.3" "181.0" "171.3" "170.0" "143.1" "181.3" "424.0" "" "" "" "" "" "" "" "" "" "" "104.3" "89.1" "113.8" "86.0" "83.9" "87.7" "79.0" "64.2" "98.4" "424.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3788247885213699411" "False" "High" "IsMasterProtein" "P04233" "HLA class II histocompatibility antigen gamma chain OS=Homo sapiens OX=9606 GN=CD74 PE=1 SV=3" "0.000" "False" "12.270" "8" "2" "3" "2" "296" "33.5" "8.44" "10.65" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00086, Pf08831, Pf09307" "972" "ENSG00000019582" "CD74" "A8K7R1; B4DNE8; D3DQG3; D3DQG4; hsa:972; P04233; Q14597; Q29832; Q5U0J8; Q8SNA0; Q8WLP6" "Macrophage markers" "MHC class II antigen presentation; Cell surface interactions at the vascular wall" "3" "0" "0.960" "1.153" "1.313" "1.309" "1.261" "1.087" "1.079" "1.064" "0.985" "85.6" "82.1" "98.6" "112.3" "112.0" "107.9" "93.0" "92.3" "91.0" "84.3" "" "" "" "" "" "" "" "" "" "" "51.2" "42.7" "54.6" "52.7" "51.9" "55.2" "43.2" "41.4" "49.4" "84.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8919089648667332764" "False" "High" "IsMasterProtein" "Q6NZY4" "Zinc finger CCHC domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZCCHC8 PE=1 SV=2" "0.000" "False" "12.265" "6" "3" "3" "3" "707" "78.5" "4.87" "7.60" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00098, Pf04046" "55596" "ENSG00000033030" "ZCCHC8" "hsa:55596; Q6NZY4; Q7L2P6; Q8N2K5; Q96SK7; Q9NSS2; Q9NSS3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3053469202622973433" "False" "High" "IsMasterProtein" "Q7L591" "Docking protein 3 OS=Homo sapiens OX=9606 GN=DOK3 PE=1 SV=2" "0.000" "False" "12.257" "8" "4" "7" "4" "496" "53.3" "7.77" "14.29" "4" "signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf02174" "79930" "ENSG00000146094" "DOK3" "E9PAT0; H7BXS0; hsa:79930; Q7L591; Q8N864; Q9BQB3; Q9H666" "5q35 copy number variation" "Neutrophil degranulation" "2" "0" "1.091" "1.038" "1.159" "1.225" "1.064" "0.973" "0.723" "1.028" "2.444" "144.2" "157.3" "149.7" "167.2" "176.7" "153.4" "140.3" "104.3" "148.2" "352.5" "" "" "" "" "" "" "" "" "" "" "86.3" "81.7" "82.9" "78.5" "81.9" "78.5" "65.2" "46.8" "80.4" "352.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7481599324901596636" "False" "High" "IsMasterProtein" "O75391" "Sperm-associated antigen 7 OS=Homo sapiens OX=9606 GN=SPAG7 PE=1 SV=2" "0.000" "False" "12.246" "16" "3" "6" "3" "227" "26.0" "7.91" "13.49" "3" "" "nucleus" "nucleic acid binding activity" "Pf01424" "9552" "ENSG00000091640" "SPAG7" "hsa:9552; O75391; Q96EU5" "" "" "0" "0" "1.030" "1.107" "1.050" "1.305" "1.186" "1.146" "1.163" "1.062" "0.575" "101.4" "104.4" "112.2" "106.4" "132.3" "120.3" "116.2" "117.9" "107.6" "58.3" "" "" "" "" "" "" "" "" "" "" "60.7" "54.3" "62.2" "50.0" "61.3" "61.6" "54.0" "52.9" "58.4" "58.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2725190465399901470" "False" "High" "IsMasterProtein" "P62829" "Large ribosomal subunit protein uL14 OS=Homo sapiens OX=9606 GN=RPL23 PE=1 SV=1" "0.000" "False" "12.244" "19" "3" "12" "3" "140" "14.9" "10.51" "23.43" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00238" "9349" "ENSG00000125691" "RPL23" "hsa:9349; P23131; P24048; P62829; Q29246; Q3SWV7; Q6P5S1" "Cytoplasmic ribosomal proteins; 17q12 copy number variation syndrome" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.921" "0.985" "1.008" "0.987" "1.005" "0.911" "0.952" "1.052" "1.791" "312.8" "288.1" "308.0" "315.4" "308.8" "314.3" "285.0" "297.9" "328.9" "560.4" "" "" "" "" "" "" "" "" "" "" "187.2" "149.7" "170.6" "148.1" "143.1" "160.9" "132.5" "133.7" "178.5" "560.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3039044237151127382" "False" "High" "IsMasterProtein" "P61163" "Alpha-centractin OS=Homo sapiens OX=9606 GN=ACTR1A PE=1 SV=1" "0.000" "False" "12.240" "9" "4" "5" "2" "376" "42.6" "6.64" "12.09" "4" "transport" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00022" "10121" "ENSG00000138107" "ACTR1A" "B2R6B0; hsa:10121; P42024; P61163" "HDAC6 interactions in the central nervous system" "COPI-mediated anterograde transport; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; MHC class II antigen presentation; Recruitment of NuMA to mitotic centrosomes; COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "12" "0" "0.960" "0.870" "0.851" "0.850" "0.915" "1.125" "1.016" "0.949" "0.650" "430.3" "413.1" "374.5" "366.3" "366.0" "393.7" "483.9" "437.0" "408.2" "279.8" "" "" "" "" "" "" "" "" "" "" "257.5" "214.7" "207.4" "172.0" "169.6" "201.6" "225.0" "196.2" "221.5" "279.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7605379253823960098" "False" "High" "IsMasterProtein" "Q96Q83" "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 OS=Homo sapiens OX=9606 GN=ALKBH3 PE=1 SV=1" "0.000" "False" "12.209" "15" "3" "4" "3" "286" "33.4" "8.40" "5.23" "3" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf13532" "221120" "ENSG00000166199" "ALKBH3" "A6NDJ1; Q3SYI0; Q6NX57; Q96BU8; Q96Q83" "Direct reversal repair; 11p11.2 copy number variation syndrome" "ALKBH3 mediated reversal of alkylation damage" "3" "0" "1.107" "0.803" "1.141" "1.230" "1.097" "1.270" "0.792" "0.807" "1.435" "24.8" "27.4" "19.9" "28.3" "30.5" "27.2" "31.4" "19.6" "20.0" "35.5" "" "" "" "" "" "" "" "" "" "" "14.8" "14.2" "11.0" "13.3" "14.1" "13.9" "14.6" "8.8" "10.8" "35.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088552440920446999" "False" "High" "IsMasterProtein" "Q9Y570" "Protein phosphatase methylesterase 1 OS=Homo sapiens OX=9606 GN=PPME1 PE=1 SV=3" "0.000" "False" "12.190" "10" "4" "16" "4" "386" "42.3" "5.97" "30.53" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf12697" "51400" "ENSG00000214517" "PPME1" "B3KMU6; B5MEE7; hsa:51400; J3QT22; Q8WYG8; Q9NVT5; Q9UI18; Q9Y570" "" "Cyclin A/B1/B2 associated events during G2/M transition" "1" "0" "1.015" "1.054" "1.157" "1.062" "1.191" "0.981" "1.127" "1.110" "1.254" "302.7" "307.3" "319.2" "350.2" "321.6" "360.5" "297.1" "341.2" "336.1" "379.6" "" "" "" "" "" "" "" "" "" "" "181.2" "159.7" "176.8" "164.4" "149.1" "184.5" "138.2" "153.2" "182.3" "379.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6933649257231024003" "False" "High" "IsMasterProtein" "P16930" "Fumarylacetoacetase OS=Homo sapiens OX=9606 GN=FAH PE=1 SV=2" "0.000" "False" "12.176" "10" "4" "7" "4" "419" "46.3" "6.95" "15.31" "4" "other metabolic processes" "cytosol" "other molecular function" "Pf01557, Pf09298" "2184" "ENSG00000103876" "FAH" "B2R9X1; D3DW95; hsa:2184; P16930; Q53XA7" "Amino acid metabolism" "Tyrosine catabolism" "2" "0" "0.858" "0.946" "0.825" "1.078" "0.872" "1.094" "0.970" "1.147" "0.617" "227.7" "195.4" "215.5" "187.8" "245.5" "198.6" "249.2" "221.0" "261.3" "140.4" "" "" "" "" "" "" "" "" "" "" "136.3" "101.6" "119.4" "88.2" "113.8" "101.6" "115.9" "99.2" "141.7" "140.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5841636671217917151" "False" "High" "IsMasterProtein" "Q5JTJ3" "Cytochrome c oxidase assembly factor 6 homolog OS=Homo sapiens OX=9606 GN=COA6 PE=1 SV=1" "0.000" "False" "12.173" "22" "2" "4" "2" "125" "14.1" "8.25" "14.00" "2" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;mitochondrion;nucleus" "other molecular function" "Pf02297" "388753" "ENSG00000168275" "COA6" "hsa:388753; Q5JTJ2; Q5JTJ3; Q5JTJ4; Q8TA88" "Mitochondrial complex IV assembly" "Mitochondrial protein import" "2" "0" "0.935" "1.036" "1.002" "1.039" "1.043" "1.020" "1.105" "1.022" "0.556" "333.3" "311.7" "345.4" "334.0" "346.5" "347.5" "340.0" "368.4" "340.5" "185.3" "" "" "" "" "" "" "" "" "" "" "199.5" "162.0" "191.3" "156.8" "160.6" "177.9" "158.1" "165.4" "184.7" "185.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "916743004623214960" "False" "High" "IsMasterProtein" "P62266" "Small ribosomal subunit protein uS12 OS=Homo sapiens OX=9606 GN=RPS23 PE=1 SV=3" "0.000" "False" "12.158" "21" "3" "6" "3" "143" "15.8" "10.49" "18.33" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00164" "6228" "ENSG00000186468" "RPS23" "hsa:6228; P39028; P62266; Q6IB08" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Formation of the ternary complex, and subsequently, the 43S complex; Response of EIF2AK4 (GCN2) to amino acid deficiency; Protein hydroxylation; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "20" "0" "0.976" "0.988" "1.163" "1.061" "1.017" "1.128" "1.134" "1.132" "1.130" "217.3" "212.2" "214.7" "252.8" "230.6" "221.0" "245.2" "246.4" "245.9" "245.6" "" "" "" "" "" "" "" "" "" "" "130.1" "110.3" "118.9" "118.7" "106.9" "113.2" "114.0" "110.6" "133.4" "245.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7337665348008384774" "False" "High" "IsMasterProtein" "O60701" "UDP-glucose 6-dehydrogenase OS=Homo sapiens OX=9606 GN=UGDH PE=1 SV=1" "0.000" "False" "12.150" "8" "4" "5" "4" "494" "55.0" "7.12" "12.83" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;nucleus" "other molecular function" "Pf00984, Pf03720, Pf03721" "7358" "ENSG00000109814" "UGDH" "B3KUU2; B4DN25; hsa:7358; O60589; O60701" "UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "Formation of the active cofactor, UDP-glucuronate" "3" "0" "0.934" "1.120" "1.363" "0.971" "0.925" "1.231" "1.278" "1.449" "1.259" "78.4" "73.2" "87.9" "106.9" "76.2" "72.6" "96.6" "100.3" "113.6" "98.7" "" "" "" "" "" "" "" "" "" "" "46.9" "38.1" "48.7" "50.2" "35.3" "37.1" "44.9" "45.0" "61.7" "98.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-397251386471415027" "False" "High" "IsMasterProtein" "Q9Y3X0" "Coiled-coil domain-containing protein 9 OS=Homo sapiens OX=9606 GN=CCDC9 PE=1 SV=1" "0.000" "False" "12.146" "8" "4" "4" "4" "531" "59.7" "5.40" "12.50" "4" "" "nucleus" "nucleic acid binding activity" "Pf15266" "26093" "ENSG00000105321" "CCDC9" "hsa:26093; Q9Y3X0" "IL-18 signaling pathway" "" "1" "0" "0.955" "0.962" "0.969" "1.004" "1.063" "1.030" "0.924" "0.966" "0.779" "272.6" "260.4" "262.3" "264.1" "273.6" "289.7" "280.8" "251.9" "263.4" "212.3" "" "" "" "" "" "" "" "" "" "" "163.1" "135.3" "145.3" "124.0" "126.8" "148.3" "130.6" "113.1" "142.9" "212.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-220187434067665020" "False" "High" "IsMasterProtein" "Q6PJT7" "Zinc finger CCCH domain-containing protein 14 OS=Homo sapiens OX=9606 GN=ZC3H14 PE=1 SV=1" "0.000" "False" "12.141" "4" "2" "2" "2" "736" "82.8" "7.31" "8.99" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf14608" "79882" "ENSG00000100722" "ZC3H14" "A8MY46; B4DXU8; B4DZW7; B4E2H4; G3V5R4; hsa:79882; Q6MZU4; Q6PJ32; Q6PJT7; Q6PUI6; Q6PUI8; Q86TQ5; Q86TW0; Q86TW1; Q8NCT6; Q8NCZ3; Q8TDE2; Q9HAC9; Q9Y5A0" "" "" "0" "0" "0.911" "0.908" "1.109" "1.284" "0.868" "1.164" "0.997" "1.055" "1.101" "50.0" "45.5" "45.4" "55.4" "64.2" "43.4" "58.2" "49.8" "52.7" "55.0" "" "" "" "" "" "" "" "" "" "" "29.9" "23.7" "25.1" "26.0" "29.7" "22.2" "27.1" "22.4" "28.6" "55.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4154792399073788951" "False" "High" "IsMasterProtein" "Q13541" "Eukaryotic translation initiation factor 4E-binding protein 1 OS=Homo sapiens OX=9606 GN=EIF4EBP1 PE=1 SV=3" "0.000" "False" "12.112" "32" "2" "5" "2" "118" "12.6" "5.48" "13.90" "2" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05456" "1978" "ENSG00000187840" "EIF4EBP1" "B2R502; D3DSW8; hsa:1978; Q13541; Q6IBN3" "Translation factors; AMP-activated protein kinase signaling; Target of rapamycin signaling; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; RAC1/PAK1/p38/MMP2 pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Hypertrophy model; Acute myeloid leukemia; Interferon type I signaling pathways; ErbB signaling pathway" "mTORC1-mediated signalling; Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S" "32" "0" "0.727" "0.835" "0.816" "1.009" "0.902" "1.024" "0.998" "0.839" "0.644" "126.7" "92.2" "105.8" "103.4" "127.9" "114.3" "129.7" "126.5" "106.4" "81.6" "" "" "" "" "" "" "" "" "" "" "75.8" "47.9" "58.6" "48.6" "59.3" "58.5" "60.3" "56.8" "57.7" "81.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4163681238843766636" "False" "High" "IsMasterProtein" "Q13144" "Translation initiation factor eIF2B subunit epsilon OS=Homo sapiens OX=9606 GN=EIF2B5 PE=1 SV=3" "0.000" "False" "12.079" "5" "3" "3" "3" "721" "80.3" "5.08" "9.27" "3" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf02020" "8893" "ENSG00000145191" "EIF2B5" "hsa:8893; Q13144; Q541Z1; Q96D04" "Translation factors; MicroRNAs in cardiomyocyte hypertrophy; DYRK1A involvement regarding cell proliferation in brain development; Primary ovarian insufficiency" "Recycling of eIF2:GDP" "5" "0" "1.180" "1.295" "1.201" "1.221" "1.116" "0.919" "1.641" "0.989" "2.390" "19.7" "23.2" "25.5" "23.7" "24.1" "22.0" "18.1" "32.3" "19.5" "47.1" "" "" "" "" "" "" "" "" "" "" "11.8" "12.1" "14.1" "11.1" "11.2" "11.3" "8.4" "14.5" "10.6" "47.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6090359432096684388" "False" "High" "IsMasterProtein" "Q8NCN5" "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Homo sapiens OX=9606 GN=PDPR PE=1 SV=2" "0.000" "False" "12.074" "5" "4" "4" "4" "879" "99.3" "6.35" "9.88" "4" "" "mitochondrion;other cell component" "other molecular function" "Pf01266, Pf01571, Pf08669, Pf16350" "55066" "ENSG00000090857" "PDPR" "A7E298; A8K8Y7; B3KSE1; Q6AI20; Q6AWC9; Q8NCN5" "" "Regulation of pyruvate dehydrogenase (PDH) complex" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4658645955564383119" "False" "High" "IsMasterProtein" "Q86Y82" "Syntaxin-12 OS=Homo sapiens OX=9606 GN=STX12 PE=1 SV=1" "0.000" "False" "12.074" "14" "3" "4" "3" "276" "31.6" "5.59" "10.39" "3" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739, Pf14523" "23673" "ENSG00000117758" "STX12" "B1AJQ7; hsa:23673; O95564; Q86Y82" "" "" "0" "0" "1.014" "1.090" "1.115" "0.840" "0.902" "0.770" "0.926" "0.897" "0.856" "58.3" "59.1" "63.5" "65.0" "49.0" "52.6" "44.9" "54.0" "52.3" "49.9" "" "" "" "" "" "" "" "" "" "" "34.9" "30.7" "35.2" "30.5" "22.7" "26.9" "20.9" "24.2" "28.4" "49.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7214504578644122811" "False" "High" "IsMasterProtein" "P62942" "Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Homo sapiens OX=9606 GN=FKBP1A PE=1 SV=2" "0.000" "False" "12.026" "28" "2" "7" "2" "108" "11.9" "8.16" "19.00" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00254" "2280" "ENSG00000088832" "FKBP1A" "D3DVW6; hsa:2280; P20071; P62942; Q4VC47; Q6FGD9; Q6LEU3; Q9H103; Q9H566" "Target of rapamycin signaling; Spinal cord injury; Head and neck squamous cell carcinoma; TGF-beta receptor signaling in skeletal dysplasias; Affected pathways in Duchenne muscular dystrophy; Calcium regulation in cardiac cells; TGF-beta receptor signaling" "Potential therapeutics for SARS; mTORC1-mediated signalling; SARS-CoV-1 activates/modulates innate immune responses; TGF-beta receptor signaling activates SMADs; Calcineurin activates NFAT; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); TGFBR1 LBD Mutants in Cancer" "14" "0" "0.926" "0.944" "1.106" "0.933" "0.841" "1.097" "0.895" "0.778" "0.576" "370.7" "343.5" "350.0" "410.1" "345.8" "311.9" "406.8" "331.6" "288.3" "213.7" "" "" "" "" "" "" "" "" "" "" "221.9" "178.5" "193.8" "192.5" "160.3" "159.7" "189.2" "148.9" "156.4" "213.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "683503187076847751" "False" "High" "IsMasterProtein" "Q96AZ6" "Interferon-stimulated gene 20 kDa protein OS=Homo sapiens OX=9606 GN=ISG20 PE=1 SV=2" "0.000" "False" "12.000" "26" "3" "3" "3" "181" "20.4" "8.92" "7.16" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00929" "3669" "ENSG00000172183" "ISG20" "hsa:3669; O00441; O00586; Q96AZ6" "" "Interferon alpha/beta signaling" "1" "0" "0.934" "1.054" "0.987" "1.176" "1.007" "1.073" "0.777" "0.915" "2.105" "67.8" "63.3" "71.4" "66.9" "79.7" "68.2" "72.7" "52.6" "62.0" "142.6" "" "" "" "" "" "" "" "" "" "" "40.6" "32.9" "39.6" "31.4" "36.9" "34.9" "33.8" "23.6" "33.6" "142.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2189379826665428433" "False" "High" "IsMasterProtein" "Q9UMY1" "U3 small nucleolar RNA-associated protein NOL7 OS=Homo sapiens OX=9606 GN=NOL7 PE=1 SV=2" "0.000" "False" "11.989" "10" "3" "5" "3" "257" "29.4" "9.67" "16.37" "3" "other biological processes" "mitochondrion;nucleus;other cell component" "" "Pf08157" "51406" "ENSG00000225921" "NOL7" "hsa:51406; Q5T297; Q9UMY1; Q9Y3U7" "" "" "0" "0" "1.043" "1.026" "0.972" "1.099" "1.078" "0.915" "1.027" "0.906" "0.321" "440.1" "459.2" "451.6" "427.6" "483.8" "474.3" "402.7" "452.0" "398.6" "141.1" "" "" "" "" "" "" "" "" "" "" "263.4" "238.6" "250.1" "200.8" "224.2" "242.8" "187.2" "202.9" "216.2" "141.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8244788051015200479" "False" "High" "IsMasterProtein" "O43447" "Peptidyl-prolyl cis-trans isomerase H OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=1" "0.000" "False" "11.989" "21" "4" "9" "4" "177" "19.2" "8.07" "19.61" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00160" "10465" "ENSG00000171960" "PPIH" "A6NNE7; hsa:10465; O43447" "" "mRNA Splicing - Major Pathway; SARS-CoV-1 activates/modulates innate immune responses" "2" "0" "1.071" "1.157" "1.268" "1.185" "1.207" "1.252" "1.172" "1.155" "2.599" "158.7" "169.9" "183.7" "201.3" "188.1" "191.6" "198.6" "185.9" "183.3" "412.5" "" "" "" "" "" "" "" "" "" "" "95.0" "88.3" "101.7" "94.5" "87.2" "98.1" "92.4" "83.5" "99.5" "412.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2229585917492551052" "False" "High" "IsMasterProtein" "P53992" "Protein transport protein Sec24C OS=Homo sapiens OX=9606 GN=SEC24C PE=1 SV=3" "0.000" "False" "11.988" "4" "4" "4" "4" "1094" "118.2" "7.06" "11.98" "4" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "9632" "ENSG00000176986" "SEC24C" "B4DZT4; hsa:9632; P53992; Q8WV25" "Sterol regulatory element-binding proteins (SREBP) signaling" "COPII-mediated vesicle transport; MHC class II antigen presentation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF)" "7" "0" "0.968" "0.922" "1.098" "1.088" "1.012" "0.993" "0.850" "1.023" "2.753" "158.8" "153.8" "146.5" "174.4" "172.8" "160.8" "157.8" "135.0" "162.4" "437.3" "" "" "" "" "" "" "" "" "" "" "95.0" "79.9" "81.1" "81.9" "80.1" "82.3" "73.4" "60.6" "88.1" "437.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5777002652342293914" "False" "High" "IsMasterProtein" "Q9H307" "Pinin OS=Homo sapiens OX=9606 GN=PNN PE=1 SV=5" "0.000" "False" "11.965" "6" "5" "7" "5" "717" "81.6" "7.14" "13.76" "5" "cell adhesion;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04696, Pf04697" "5411" "ENSG00000100941" "PNN" "B4DZX8; hsa:5411; O60899; Q53EM7; Q6P5X4; Q7KYL1; Q99738; Q9H307; Q9UHZ9; Q9UQR9" "" "mRNA Splicing - Major Pathway" "1" "0" "1.013" "1.050" "1.023" "1.275" "1.079" "1.321" "1.237" "1.274" "0.730" "154.5" "156.5" "162.2" "158.1" "197.1" "166.7" "204.1" "191.1" "196.9" "112.7" "" "" "" "" "" "" "" "" "" "" "92.5" "81.3" "89.8" "74.2" "91.3" "85.3" "94.9" "85.8" "106.8" "112.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3934808494784224808" "False" "High" "IsMasterProtein" "Q96FJ2" "Dynein light chain 2, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL2 PE=1 SV=1" "0.000" "False" "11.943" "45" "3" "7" "2" "89" "10.3" "7.37" "18.53" "3" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf01221" "140735" "ENSG00000264364" "DYNLL2" "B2R5B4; hsa:140735; Q96FJ2" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome; Vasopressin-regulated water reabsorption" "Separation of Sister Chromatids; MHC class II antigen presentation; Aggrephagy; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Intraflagellar transport; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Macroautophagy; Activation of BMF and translocation to mitochondria" "19" "0" "0.965" "1.005" "0.797" "1.039" "1.043" "0.860" "0.993" "1.085" "0.888" "693.3" "668.9" "696.9" "552.9" "720.4" "722.9" "596.6" "688.6" "752.1" "615.7" "" "" "" "" "" "" "" "" "" "" "414.9" "347.6" "385.9" "259.6" "333.9" "370.0" "277.4" "309.1" "408.0" "615.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4400189645946568146" "False" "High" "IsMasterProtein" "O00488" "Zinc finger protein 593 OS=Homo sapiens OX=9606 GN=ZNF593 PE=1 SV=2" "0.000" "False" "11.924" "31" "3" "5" "3" "134" "15.2" "9.82" "9.96" "3" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12171" "51042" "ENSG00000142684" "ZNF593" "B2R4S0; hsa:51042; O00488; Q5T2H7" "" "" "0" "0" "1.120" "1.035" "1.203" "1.089" "1.270" "0.976" "1.241" "1.198" "0.598" "88.1" "98.8" "91.2" "106.0" "96.0" "112.0" "86.0" "109.4" "105.6" "52.7" "" "" "" "" "" "" "" "" "" "" "52.7" "51.3" "50.5" "49.8" "44.5" "57.3" "40.0" "49.1" "57.3" "52.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1011365371626777610" "False" "High" "IsMasterProtein" "P56277" "Cx9C motif-containing protein 4 OS=Homo sapiens OX=9606 GN=CMC4 PE=1 SV=1" "0.000" "False" "11.922" "38" "3" "4" "3" "68" "7.7" "8.18" "12.28" "3" "" "mitochondrion" "" "Pf08991" "100272147" "ENSG00000182712" "CMC4" "hsa:100272147; P56277; Q5HYP9" "" "Mitochondrial protein import" "1" "0" "1.056" "1.088" "1.117" "1.011" "1.041" "1.132" "1.170" "1.094" "0.507" "95.4" "100.7" "103.7" "106.5" "96.4" "99.3" "108.0" "111.5" "104.3" "48.3" "" "" "" "" "" "" "" "" "" "" "57.1" "52.3" "57.4" "50.0" "44.7" "50.8" "50.2" "50.1" "56.6" "48.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1178646061152564690" "False" "High" "IsMasterProtein" "P40938" "Replication factor C subunit 3 OS=Homo sapiens OX=9606 GN=RFC3 PE=1 SV=2" "0.000" "False" "11.919" "10" "3" "5" "3" "356" "40.5" "8.34" "8.71" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13177" "5983" "ENSG00000133119" "RFC3" "C9JU95; hsa:5983; O15252; P40938; Q5W0E8" "Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "28" "0" "0.982" "1.051" "1.185" "0.908" "1.188" "1.323" "1.017" "1.163" "3.590" "62.2" "61.0" "65.3" "73.7" "56.5" "73.9" "82.3" "63.2" "72.3" "223.2" "" "" "" "" "" "" "" "" "" "" "37.2" "31.7" "36.2" "34.6" "26.2" "37.8" "38.3" "28.4" "39.2" "223.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5628427782035597939" "False" "High" "IsMasterProtein" "P20336" "Ras-related protein Rab-3A OS=Homo sapiens OX=9606 GN=RAB3A PE=1 SV=1" "0.000" "False" "11.911" "12" "2" "9" "1" "220" "25.0" "5.03" "25.65" "2" "cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "5864" "ENSG00000105649" "RAB3A" "A8K0J4; hsa:5864; P20336; Q9NYE1" "Synaptic vesicle pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Intracellular trafficking proteins involved in CMT neuropathy" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Sensory processing of sound by inner hair cells of the cochlea; Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; GABA synthesis, release, reuptake and degradation" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9200930033631648957" "False" "High" "IsMasterProtein" "Q06413" "Myocyte-specific enhancer factor 2C OS=Homo sapiens OX=9606 GN=MEF2C PE=1 SV=1" "0.000" "False" "11.873" "11" "4" "5" "2" "473" "51.2" "8.03" "12.55" "4" "cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4208" "ENSG00000081189" "MEF2C" "C9JMZ0; D7F7N5; F8W7V7; hsa:4208; Q06413" "Energy metabolism; Heart development; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; B cell receptor signaling pathway; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Prion disease pathway; Rett syndrome; EGF/EGFR signaling pathway; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; GDNF signaling; 2q37 copy number variation syndrome; Neurogenesis regulation in the olfactory epithelium; Sudden infant death syndrome (SIDS) susceptibility pathways" "ERK/MAPK targets; Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Myogenesis; Cardiogenesis; MECP2 regulates transcription factors" "30" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-379596745727063060" "False" "High" "IsMasterProtein" "Q96CW6" "Probable RNA polymerase II nuclear localization protein SLC7A6OS OS=Homo sapiens OX=9606 GN=SLC7A6OS PE=1 SV=2" "0.000" "False" "11.871" "15" "4" "5" "4" "309" "35.0" "4.60" "5.92" "4" "transport;other biological processes" "nucleus;other cell component" "" "Pf08574" "84138" "ENSG00000103061" "SLC7A6OS" "hsa:84138; Q8TCZ3; Q96CW6; Q9H8R8" "" "" "0" "0" "1.145" "0.826" "1.033" "0.918" "0.953" "1.232" "1.227" "1.006" "0.717" "38.5" "44.1" "31.8" "39.8" "35.4" "36.7" "47.5" "47.3" "38.8" "27.6" "" "" "" "" "" "" "" "" "" "" "23.1" "22.9" "17.6" "18.7" "16.4" "18.8" "22.1" "21.2" "21.0" "27.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "774032980472200148" "False" "High" "IsMasterProtein" "P80404" "4-aminobutyrate aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=ABAT PE=1 SV=3" "0.000" "False" "11.859" "6" "3" "3" "3" "500" "56.4" "7.96" "10.42" "3" "other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00202" "18" "ENSG00000183044" "ABAT" "A8K386; hsa:18; P80404; Q16260; Q8N5W2; Q96BG2; Q99800" "Alanine and aspartate metabolism; Valproic acid pathway; Fragile X syndrome" "Degradation of GABA" "4" "0" "1.006" "0.997" "0.904" "0.916" "1.105" "0.789" "1.035" "0.995" "0.637" "187.2" "188.3" "186.6" "169.3" "171.6" "207.0" "147.8" "193.8" "186.2" "119.4" "" "" "" "" "" "" "" "" "" "" "112.1" "97.8" "103.3" "79.5" "79.5" "105.9" "68.7" "87.0" "101.0" "119.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4257366520332167042" "False" "High" "IsMasterProtein" "Q13422" "DNA-binding protein Ikaros OS=Homo sapiens OX=9606 GN=IKZF1 PE=1 SV=1" "0.000" "False" "11.855" "8" "4" "7" "4" "519" "57.5" "6.58" "16.86" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "10320" "ENSG00000185811" "IKZF1" "A4D260; B4E0Z1; D3DVM5; hsa:10320; O00598; Q13422; Q53XL2; Q69BM4; Q8WVA3" "Hematopoietic stem cell differentiation; Development of pulmonary dendritic cells and macrophage subsets" "" "2" "0" "0.944" "0.960" "0.826" "0.886" "0.906" "0.968" "0.876" "1.033" "1.157" "173.9" "164.2" "166.9" "143.6" "154.2" "157.6" "168.4" "152.3" "179.6" "201.2" "" "" "" "" "" "" "" "" "" "" "104.1" "85.3" "92.4" "67.4" "71.5" "80.7" "78.3" "68.4" "97.4" "201.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6634155616669097337" "False" "High" "IsMasterProtein" "P42768" "Actin nucleation-promoting factor WAS OS=Homo sapiens OX=9606 GN=WAS PE=1 SV=4" "0.000" "False" "11.849" "9" "3" "5" "3" "502" "52.9" "6.64" "11.02" "3" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00568, Pf00786, Pf02205" "7454" "ENSG00000015285" "WAS" "hsa:7454; P42768; Q9BU11; Q9UNJ9" "Pathogenic Escherichia coli infection; Complement system; Chemokine signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; T-cell receptor signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Generation of second messenger molecules; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOJ GTPase cycle" "13" "0" "0.841" "1.039" "1.093" "1.014" "0.971" "0.899" "0.471" "1.244" "4.396" "90.4" "76.0" "94.0" "98.8" "91.7" "87.8" "81.3" "42.6" "112.4" "397.4" "" "" "" "" "" "" "" "" "" "" "54.1" "39.5" "52.0" "46.4" "42.5" "45.0" "37.8" "19.1" "61.0" "397.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5526079506929447963" "False" "High" "IsMasterProtein" "O14617" "AP-3 complex subunit delta-1 OS=Homo sapiens OX=9606 GN=AP3D1 PE=1 SV=1" "0.000" "False" "11.836" "4" "3" "3" "3" "1153" "130.1" "8.48" "4.60" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01602, Pf06375" "8943" "ENSG00000065000" "AP3D1" "O00202; O14617; O75262; Q59HF5; Q96G11; Q9H3C6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2492385812914646204" "False" "High" "IsMasterProtein" "O14730" "Serine/threonine-protein kinase RIO3 OS=Homo sapiens OX=9606 GN=RIOK3 PE=1 SV=2" "0.000" "False" "11.807" "6" "4" "4" "4" "519" "59.1" "5.76" "10.43" "4" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01163" "8780" "ENSG00000101782" "RIOK3" "O14730; Q8IXN9" "Hematopoietic stem cell differentiation" "Major pathway of rRNA processing in the nucleolus and cytosol" "2" "0" "0.930" "0.940" "0.845" "1.019" "1.017" "1.057" "1.037" "1.168" "0.699" "106.9" "99.3" "100.4" "90.3" "109.0" "108.7" "113.0" "110.8" "124.8" "74.7" "" "" "" "" "" "" "" "" "" "" "64.0" "51.6" "55.6" "42.4" "50.5" "55.7" "52.5" "49.7" "67.7" "74.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5831318780158998432" "False" "High" "IsMasterProtein" "Q9H0C8" "Integrin-linked kinase-associated serine/threonine phosphatase 2C OS=Homo sapiens OX=9606 GN=ILKAP PE=1 SV=1" "0.000" "False" "11.787" "9" "4" "7" "4" "392" "42.9" "7.09" "15.64" "4" "" "other cell component" "other molecular function" "Pf00481" "80895" "ENSG00000132323" "ILKAP" "B3KM39; hsa:80895; Q9H0C8" "2q37 copy number variation syndrome" "" "1" "0" "1.162" "1.143" "1.017" "1.191" "1.063" "1.092" "0.559" "1.078" "5.100" "129.7" "150.7" "148.2" "131.8" "154.4" "137.9" "141.6" "72.4" "139.8" "661.4" "" "" "" "" "" "" "" "" "" "" "77.6" "78.3" "82.1" "61.9" "71.6" "70.6" "65.9" "32.5" "75.8" "661.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1726456948051343577" "False" "High" "IsMasterProtein" "Q96G46" "tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like OS=Homo sapiens OX=9606 GN=DUS3L PE=1 SV=2" "0.000" "False" "11.786" "8" "3" "3" "3" "650" "72.5" "8.05" "6.80" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "" "other molecular function" "Pf01207" "56931" "ENSG00000141994" "DUS3L" "hsa:56931; Q96G46; Q96HM5; Q9BSU4; Q9H877; Q9NPR1" "" "" "0" "0" "0.883" "1.012" "0.923" "1.049" "0.826" "0.869" "0.808" "0.886" "1.915" "81.7" "72.2" "82.7" "75.4" "85.7" "67.6" "71.0" "66.0" "72.4" "156.5" "" "" "" "" "" "" "" "" "" "" "48.9" "37.5" "45.8" "35.4" "39.7" "34.6" "33.0" "29.6" "39.3" "156.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3125031583536319160" "False" "High" "IsMasterProtein" "P05204" "Non-histone chromosomal protein HMG-17 OS=Homo sapiens OX=9606 GN=HMGN2 PE=1 SV=3" "0.000" "False" "11.773" "22" "2" "7" "2" "90" "9.4" "9.99" "14.15" "2" "cell organization and biogenesis;stress response;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "3151" "ENSG00000198830" "HMGN2" "hsa:3151; P05204; Q0VGD5; Q6FGI5; Q96C64" "" "" "0" "0" "1.264" "1.516" "1.786" "1.625" "1.440" "1.301" "1.660" "1.461" "0.474" "346.9" "438.4" "525.8" "619.5" "563.6" "499.5" "451.3" "575.7" "507.0" "164.5" "" "" "" "" "" "" "" "" "" "" "207.6" "227.8" "291.2" "290.9" "261.2" "255.7" "209.9" "258.5" "275.0" "164.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3677224009341935597" "False" "High" "IsMasterProtein" "P48729" "Casein kinase I isoform alpha OS=Homo sapiens OX=9606 GN=CSNK1A1 PE=1 SV=2" "0.000" "False" "11.744" "15" "4" "5" "4" "337" "38.9" "9.57" "12.66" "4" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1452" "ENSG00000113712" "CSNK1A1" "D3DQG0; D3DQG1; hsa:1452; P48729; Q4JJA0; Q5U046; Q5U047; Q6FGA2; Q71TU5; Q96HD2; Q9UDK3" "Alzheimer's disease and miRNA effects; T cell receptor and co-stimulatory signaling; Complement system; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Chromosomal and microsatellite instability in colorectal cancer ; Hedgehog signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Alzheimer's disease; DYRK1A involvement regarding cell proliferation in brain development" "Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Activation of SMO; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Maturation of nucleoprotein" "32" "0" "1.011" "1.130" "1.245" "1.147" "1.089" "1.128" "1.204" "1.241" "1.705" "91.6" "92.7" "103.5" "114.1" "105.1" "99.8" "103.4" "110.3" "113.7" "156.2" "" "" "" "" "" "" "" "" "" "" "54.8" "48.2" "57.3" "53.6" "48.7" "51.1" "48.1" "49.5" "61.7" "156.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4812205563963537221" "False" "High" "IsMasterProtein" "Q9BSH5" "Haloacid dehalogenase-like hydrolase domain-containing protein 3 OS=Homo sapiens OX=9606 GN=HDHD3 PE=1 SV=1" "0.000" "False" "11.726" "13" "3" "4" "3" "251" "28.0" "6.71" "13.30" "3" "" "nucleus;other cell component" "" "Pf00702" "81932" "ENSG00000119431" "HDHD3" "B2RD47; hsa:81932; Q9BSH5" "" "" "0" "0" "0.916" "0.861" "1.010" "1.026" "0.999" "0.913" "0.944" "0.947" "0.643" "279.1" "255.7" "240.3" "281.9" "286.2" "278.9" "254.8" "263.5" "264.3" "179.4" "" "" "" "" "" "" "" "" "" "" "167.0" "132.9" "133.1" "132.3" "132.7" "142.8" "118.5" "118.3" "143.4" "179.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3953931010856732739" "False" "High" "IsMasterProtein" "P16104" "Histone H2AX OS=Homo sapiens OX=9606 GN=H2AX PE=1 SV=2" "0.000" "False" "11.703" "22" "4" "13" "1" "143" "15.1" "10.74" "33.31" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "3014" "ENSG00000188486" "H2AX" "hsa:3014; P16104; Q4ZGJ7; Q6IAS5" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Proteasome degradation; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; DNA repair pathways, full network; 5q35 copy number variation; DNA damage response" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Assembly of the ORC complex at the origin of replication; Amyloid fiber formation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Oxidative Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Processing of DNA double-strand break ends; RMTs methylate histone arginines; Meiotic synapsis; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; G2/M DNA damage checkpoint; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; Nonhomologous End-Joining (NHEJ); RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "47" "3" "0.799" "0.940" "0.830" "0.860" "0.843" "0.797" "0.683" "0.800" "0.980" "1152.4" "920.7" "1082.7" "957.1" "990.5" "971.8" "918.0" "787.3" "922.3" "1129.1" "" "" "" "" "" "" "" "" "" "" "689.6" "478.4" "599.6" "449.3" "459.1" "497.5" "426.9" "353.5" "500.4" "1129.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7638543548033193713" "False" "High" "IsMasterProtein" "Q00765" "Receptor expression-enhancing protein 5 OS=Homo sapiens OX=9606 GN=REEP5 PE=1 SV=3" "0.000" "False" "11.699" "15" "3" "4" "3" "189" "21.5" "8.10" "12.85" "3" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf03134" "7905" "ENSG00000129625" "REEP5" "B7Z681; D3DT04; hsa:7905; Q00765; Q04198; Q5QGT0; Q9BWH9" "" "" "0" "0" "1.202" "1.148" "1.081" "1.398" "1.288" "1.163" "1.230" "1.235" "1.090" "92.2" "110.8" "105.8" "99.6" "128.8" "118.7" "107.2" "113.3" "113.8" "100.5" "" "" "" "" "" "" "" "" "" "" "55.1" "57.6" "58.6" "46.8" "59.7" "60.8" "49.8" "50.9" "61.8" "100.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491360545906137157" "False" "High" "IsMasterProtein" "P54920" "Alpha-soluble NSF attachment protein OS=Homo sapiens OX=9606 GN=NAPA PE=1 SV=3" "0.000" "False" "11.694" "9" "3" "4" "3" "295" "33.2" "5.36" "12.76" "3" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf14938" "8775" "ENSG00000105402" "NAPA" "A8K879; hsa:8775; P54920; Q96IK3; Q9BVJ3" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling" "Golgi Associated Vesicle Biogenesis; Retrograde transport at the Trans-Golgi-Network; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport" "8" "0" "1.241" "1.207" "1.270" "1.376" "1.139" "1.242" "1.062" "1.368" "2.020" "121.1" "150.3" "146.1" "153.8" "166.6" "137.9" "150.4" "128.7" "165.6" "244.6" "" "" "" "" "" "" "" "" "" "" "72.5" "78.1" "80.9" "72.2" "77.2" "70.6" "70.0" "57.8" "89.9" "244.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8229141518412539790" "False" "High" "IsMasterProtein" "P68036" "Ubiquitin-conjugating enzyme E2 L3 OS=Homo sapiens OX=9606 GN=UBE2L3 PE=1 SV=1" "0.000" "False" "11.679" "16" "3" "10" "3" "154" "17.9" "8.51" "29.12" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00179" "7332" "ENSG00000185651" "UBE2L3" "B2R4A7; B4DDG1; B4DSZ4; E7EWS7; hsa:7332; P51966; P68036; P70653; Q9HAV1" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "Antigen processing: Ubiquitination & Proteasome degradation; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Regulation of necroptotic cell death; Regulation of TNFR1 signaling" "7" "0" "0.986" "0.946" "0.932" "0.963" "0.919" "1.073" "1.023" "0.941" "0.535" "1162.3" "1146.5" "1099.1" "1082.8" "1119.0" "1067.9" "1246.7" "1189.0" "1093.6" "622.2" "" "" "" "" "" "" "" "" "" "" "695.6" "595.8" "608.7" "508.4" "518.7" "546.7" "579.7" "533.8" "593.3" "622.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5381164833794741619" "False" "High" "IsMasterProtein" "Q9Y5K6" "CD2-associated protein OS=Homo sapiens OX=9606 GN=CD2AP PE=1 SV=1" "0.000" "False" "11.615" "6" "4" "4" "4" "639" "71.4" "6.40" "9.75" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf07653, Pf14604" "23607" "ENSG00000198087" "CD2AP" "A6NL34; hsa:23607; Q5VYA3; Q9UG97; Q9Y5K6" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome; Genes controlling nephrogenesis; GDNF signaling" "Nephrin family interactions" "5" "0" "1.090" "1.206" "1.126" "1.060" "1.074" "1.074" "1.044" "1.085" "2.146" "174.9" "190.7" "210.9" "197.0" "185.4" "187.8" "187.8" "182.6" "189.7" "375.4" "" "" "" "" "" "" "" "" "" "" "104.7" "99.1" "116.8" "92.5" "85.9" "96.1" "87.3" "82.0" "102.9" "375.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9082551203190853772" "False" "High" "IsMasterProtein" "Q16777" "Histone H2A type 2-C OS=Homo sapiens OX=9606 GN=H2AC20 PE=1 SV=4" "0.000" "False" "11.605" "33" "4" "12" "1" "129" "14.0" "10.90" "28.80" "4" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "8338" "ENSG00000184260" "H2AC20" "hsa:8338; Q16777; Q6DRA7; Q8IUE5" "" "HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; UCH proteinases; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of the beta-catenin:TCF transactivating complex; RMTs methylate histone arginines; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Amyloid fiber formation; Meiotic synapsis; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; HDACs deacetylate histones; Metalloprotease DUBs; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Chromatin modifications during the maternal to zygotic transition (MZT); Meiotic recombination; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis" "42" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "157210626844435621" "False" "High" "IsMasterProtein" "Q8IUI4" "Putative protein SNX29P2 OS=Homo sapiens OX=9606 GN=SNX29P2 PE=5 SV=2" "0.000" "False" "11.598" "14" "4" "8" "4" "249" "27.2" "4.94" "19.46" "4" "" "" "" "" "" "" "SNX29P2" "Q8IUI4" "" "" "0" "0" "1.053" "1.248" "1.420" "1.412" "1.293" "1.242" "1.090" "1.143" "2.050" "101.2" "106.5" "126.3" "143.6" "142.8" "130.8" "125.6" "110.2" "115.6" "207.3" "" "" "" "" "" "" "" "" "" "" "60.5" "55.4" "69.9" "67.4" "66.2" "67.0" "58.4" "49.5" "62.7" "207.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1819125433981479748" "False" "High" "IsMasterProtein" "Q15404" "Ras suppressor protein 1 OS=Homo sapiens OX=9606 GN=RSU1 PE=1 SV=3" "0.000" "False" "11.572" "9" "3" "4" "3" "277" "31.5" "8.65" "9.65" "3" "signal transduction;other biological processes" "cytosol;other cell component" "" "Pf13855" "6251" "ENSG00000148484" "RSU1" "A8KA46; D3DRU3; hsa:6251; Q15404; Q6FI17" "" "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "1" "0" "1.038" "1.016" "1.043" "1.067" "0.968" "0.996" "0.984" "1.137" "1.221" "341.5" "354.5" "346.9" "356.2" "364.3" "330.6" "340.1" "336.1" "388.2" "416.8" "" "" "" "" "" "" "" "" "" "" "204.4" "184.2" "192.1" "167.2" "168.9" "169.3" "158.2" "150.9" "210.6" "416.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8706245126759521959" "False" "High" "IsMasterProtein" "Q9BRP4" "Proteasomal ATPase-associated factor 1 OS=Homo sapiens OX=9606 GN=PAAF1 PE=1 SV=2" "0.000" "False" "11.547" "9" "4" "4" "4" "392" "42.2" "6.32" "10.19" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf00400" "80227" "ENSG00000175575" "PAAF1" "A6NDR5; B4DPB0; B7ZAS9; hsa:80227; Q4G165; Q53HS9; Q7Z500; Q8TBU6; Q9BRP4; Q9HAB6" "" "" "0" "0" "1.030" "1.058" "1.103" "1.138" "1.018" "1.035" "1.027" "1.113" "0.995" "295.0" "303.9" "312.2" "325.2" "335.8" "300.2" "305.4" "303.0" "328.4" "293.5" "" "" "" "" "" "" "" "" "" "" "176.5" "157.9" "172.9" "152.7" "155.7" "153.7" "142.0" "136.0" "178.1" "293.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2129800861400375686" "False" "High" "IsMasterProtein" "O60220" "Mitochondrial import inner membrane translocase subunit Tim8 A OS=Homo sapiens OX=9606 GN=TIMM8A PE=1 SV=1" "0.000" "False" "11.546" "34" "3" "3" "3" "97" "11.0" "5.16" "9.94" "3" "cell organization and biogenesis;transport;developmental processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "1678" "ENSG00000126953" "TIMM8A" "B2R5A6; O60220; Q6IRW6" "" "Mitochondrial protein import" "1" "0" "1.106" "0.962" "0.991" "1.037" "0.869" "0.987" "0.938" "0.926" "0.488" "277.4" "306.7" "267.0" "274.9" "287.7" "241.1" "273.9" "260.1" "256.8" "135.4" "" "" "" "" "" "" "" "" "" "" "166.0" "159.4" "147.8" "129.1" "133.3" "123.4" "127.4" "116.8" "139.3" "135.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8542796064985296864" "False" "High" "IsMasterProtein" "Q969Y2" "tRNA modification GTPase GTPBP3, mitochondrial OS=Homo sapiens OX=9606 GN=GTPBP3 PE=1 SV=2" "0.000" "False" "11.543" "12" "5" "8" "5" "492" "52.0" "6.48" "11.44" "5" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf01926, Pf10396, Pf12631" "84705" "ENSG00000130299" "GTPBP3" "A6NFH1; A6NIG5; A6NKR4; A8K7B4; B7Z4V8; hsa:84705; Q8TCY6; Q8WUW9; Q969G4; Q969Y2; Q9BX61" "" "tRNA modification in the mitochondrion" "1" "0" "0.988" "1.062" "1.258" "1.018" "1.148" "1.231" "1.099" "1.081" "0.905" "221.6" "218.9" "235.3" "278.7" "225.6" "254.3" "272.8" "243.6" "239.4" "200.5" "" "" "" "" "" "" "" "" "" "" "132.6" "113.7" "130.3" "130.8" "104.6" "130.2" "126.9" "109.3" "129.9" "200.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "896567990825277729" "False" "High" "IsMasterProtein" "O94925" "Glutaminase kidney isoform, mitochondrial OS=Homo sapiens OX=9606 GN=GLS PE=1 SV=1" "0.000" "False" "11.541" "3" "2" "3" "2" "669" "73.4" "7.77" "10.53" "2" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf04960, Pf12796, Pf17959" "2744" "ENSG00000115419" "GLS" "hsa:2744; O94925; Q9UL05; Q9UL06; Q9UL07; Q9UN40" "Amino acid metabolism; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells; Cell lineage map for neuronal differentiation" "Glutamate Neurotransmitter Release Cycle; TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism" "8" "0" "1.162" "1.140" "1.134" "1.310" "1.117" "1.271" "1.161" "0.955" "3.077" "193.9" "225.3" "221.1" "219.8" "253.9" "216.6" "246.5" "225.0" "185.1" "596.5" "" "" "" "" "" "" "" "" "" "" "116.0" "117.1" "122.4" "103.2" "117.7" "110.9" "114.6" "101.0" "100.4" "596.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8219779968186532826" "False" "High" "IsMasterProtein" "Q9UI26" "Importin-11 OS=Homo sapiens OX=9606 GN=IPO11 PE=1 SV=1" "0.000" "False" "11.531" "4" "3" "3" "3" "975" "112.5" "5.25" "9.43" "3" "transport" "cytosol;nucleus" "other molecular function" "Pf03810" "51194" "ENSG00000086200" "IPO11" "A6NGJ5; B4DZ73; D3DW98; hsa:51194; Q8N5R2; Q9NSJ6; Q9NVB1; Q9UI26" "" "" "0" "0" "1.039" "1.021" "1.158" "1.095" "1.100" "1.134" "0.974" "1.058" "1.645" "128.6" "133.6" "131.3" "148.9" "140.8" "141.4" "145.8" "125.3" "136.0" "211.5" "" "" "" "" "" "" "" "" "" "" "76.9" "69.4" "72.7" "69.9" "65.3" "72.4" "67.8" "56.2" "73.8" "211.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4637087941136759499" "False" "High" "IsMasterProtein" "O15126" "Secretory carrier-associated membrane protein 1 OS=Homo sapiens OX=9606 GN=SCAMP1 PE=1 SV=2" "0.000" "False" "11.515" "12" "4" "4" "4" "338" "37.9" "7.42" "8.21" "4" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04144" "9522" "ENSG00000085365" "SCAMP1" "hsa:9522; O15126; O43587; Q6FG23; Q96BX1; Q96QK5" "" "Neutrophil degranulation" "1" "0" "1.027" "1.019" "1.052" "0.947" "1.002" "0.999" "1.073" "0.950" "0.688" "400.7" "411.4" "408.2" "421.7" "379.3" "401.4" "400.2" "430.0" "380.5" "275.5" "" "" "" "" "" "" "" "" "" "" "239.8" "213.8" "226.0" "198.0" "175.8" "205.5" "186.1" "193.1" "206.5" "275.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6779909124529057950" "False" "High" "IsMasterProtein" "Q16773" "Kynurenine--oxoglutarate transaminase 1 OS=Homo sapiens OX=9606 GN=KYAT1 PE=1 SV=1" "0.000" "False" "11.508" "5" "2" "6" "1" "422" "47.8" "6.47" "13.75" "2" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00155" "883" "ENSG00000171097" "KYAT1" "hsa:883; Q16773; Q5T275; Q8N191" "" "Tryptophan catabolism; Glutamate and glutamine metabolism; Phenylalanine metabolism" "3" "0" "0.801" "1.039" "1.348" "0.639" "0.881" "0.944" "0.910" "1.142" "0.454" "27.9" "22.3" "29.0" "37.6" "17.8" "24.5" "26.3" "25.4" "31.8" "12.6" "" "" "" "" "" "" "" "" "" "" "16.7" "11.6" "16.0" "17.6" "8.3" "12.6" "12.2" "11.4" "17.3" "12.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-10968856719763814" "False" "High" "IsMasterProtein" "P62081" "Small ribosomal subunit protein eS7 OS=Homo sapiens OX=9606 GN=RPS7 PE=1 SV=1" "0.000" "False" "11.507" "13" "3" "6" "3" "194" "22.1" "10.10" "17.19" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01251" "6201" "ENSG00000171863" "RPS7" "hsa:6201; P23821; P24818; P62081; Q57Z92; Q6IPH1" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery; rRNA modification in the nucleus and cytosol" "20" "0" "0.966" "0.904" "0.847" "1.047" "1.105" "0.817" "1.020" "1.078" "1.554" "313.8" "303.0" "283.8" "265.7" "328.6" "346.8" "256.4" "320.1" "338.3" "487.7" "" "" "" "" "" "" "" "" "" "" "187.8" "157.4" "157.1" "124.7" "152.3" "177.5" "119.2" "143.7" "183.5" "487.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2420827179212213562" "False" "High" "IsMasterProtein" "P30622" "CAP-Gly domain-containing linker protein 1 OS=Homo sapiens OX=9606 GN=CLIP1 PE=1 SV=2" "0.000" "False" "11.507" "3" "5" "5" "5" "1438" "162.1" "5.36" "10.62" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf16641" "6249" "ENSG00000130779" "CLIP1" "A0AVD3; hsa:6249; P30622; Q17RS4; Q29RG0" "Microtubule cytoskeleton regulation; PAFAH1B1 copy number variation" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases activate IQGAPs; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "9" "0" "0.812" "0.808" "1.077" "0.760" "0.720" "1.074" "0.799" "0.846" "0.503" "44.5" "36.2" "36.0" "47.9" "33.9" "32.1" "47.8" "35.6" "37.7" "22.4" "" "" "" "" "" "" "" "" "" "" "26.6" "18.8" "19.9" "22.5" "15.7" "16.4" "22.2" "16.0" "20.4" "22.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6685402705848511390" "False" "High" "IsMasterProtein" "Q92820" "Gamma-glutamyl hydrolase OS=Homo sapiens OX=9606 GN=GGH PE=1 SV=2" "0.000" "False" "11.502" "8" "3" "7" "3" "318" "35.9" "7.11" "9.57" "3" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00117, Pf07722" "8836" "ENSG00000137563" "GGH" "hsa:8836; Q92820" "Fluoropyrimidine activity" "Neutrophil degranulation" "2" "0" "0.960" "1.048" "1.239" "0.962" "1.118" "1.203" "1.068" "1.158" "0.817" "200.7" "192.6" "210.2" "248.7" "193.1" "224.4" "241.3" "214.4" "232.3" "163.9" "" "" "" "" "" "" "" "" "" "" "120.1" "100.1" "116.4" "116.7" "89.5" "114.9" "112.2" "96.2" "126.0" "163.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2031700092780878303" "False" "High" "IsMasterProtein" "Q9Y5L4" "Mitochondrial import inner membrane translocase subunit Tim13 OS=Homo sapiens OX=9606 GN=TIMM13 PE=1 SV=1" "0.000" "False" "11.501" "15" "1" "12" "1" "95" "10.5" "8.18" "25.20" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf02953" "26517" "ENSG00000099800" "TIMM13" "hsa:26517; P62206; Q9UHL8; Q9WTL1; Q9Y5L4" "" "Mitochondrial protein import" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "117262061430317364" "False" "High" "IsMasterProtein" "Q96T88" "E3 ubiquitin-protein ligase UHRF1 OS=Homo sapiens OX=9606 GN=UHRF1 PE=1 SV=1" "0.000" "False" "11.496" "3" "2" "2" "2" "793" "89.8" "7.56" "7.88" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00628, Pf02182, Pf12148" "29128" "ENSG00000276043" "UHRF1" "A0JBR2; A8K024; B2RBA9; Q2HIX7; Q8J022; Q96T88; Q9H6S6; Q9P115; Q9P1U7" "Pathways affected in adenoid cystic carcinoma; Pleural mesothelioma" "Chromatin modifications during the maternal to zygotic transition (MZT); DNA methylation" "4" "0" "0.825" "0.726" "0.750" "1.043" "0.850" "0.860" "0.023" "1.053" "8.955" "34.2" "28.2" "24.8" "25.6" "35.6" "29.0" "29.4" "0.8" "36.0" "305.9" "" "" "" "" "" "" "" "" "" "" "20.4" "14.6" "13.7" "12.0" "16.5" "14.9" "13.7" "0.4" "19.5" "305.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5981355964815445657" "False" "High" "IsMasterProtein" "P35611" "Alpha-adducin OS=Homo sapiens OX=9606 GN=ADD1 PE=1 SV=2" "0.000" "False" "11.485" "4" "2" "3" "2" "737" "80.9" "5.83" "7.34" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "118" "ENSG00000087274" "ADD1" "A2A3N8; A2A3P0; B4DI79; D3DVR3; D3DVR4; D3DVR5; hsa:118; P35611; Q13734; Q14729; Q16156; Q86XM2; Q9UJB6" "" "XBP1(S) activates chaperone genes; Caspase-mediated cleavage of cytoskeletal proteins; Miscellaneous transport and binding events" "3" "0" "1.302" "1.214" "1.126" "1.062" "0.986" "1.249" "1.275" "1.329" "0.610" "88.4" "115.1" "107.4" "99.5" "93.9" "87.2" "110.4" "112.7" "117.5" "54.0" "" "" "" "" "" "" "" "" "" "" "52.9" "59.8" "59.5" "46.7" "43.5" "44.6" "51.4" "50.6" "63.8" "54.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3676501743634657271" "False" "High" "IsMasterProtein" "P40855" "Peroxisomal biogenesis factor 19 OS=Homo sapiens OX=9606 GN=PEX19 PE=1 SV=1" "0.000" "False" "11.475" "20" "4" "4" "4" "299" "32.8" "4.34" "7.81" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04614" "5824" "ENSG00000162735" "PEX19" "D3DVE7; E9PPB4; G3V3G9; hsa:5824; P40855; Q5QNY4; Q8NI97" "TAR syndrome" "Class I peroxisomal membrane protein import; ABC transporters in lipid homeostasis" "3" "0" "1.209" "0.937" "0.928" "0.836" "0.692" "0.757" "0.869" "0.834" "0.501" "44.1" "53.3" "41.3" "41.0" "36.9" "30.5" "33.4" "38.3" "36.8" "22.1" "" "" "" "" "" "" "" "" "" "" "26.4" "27.7" "22.9" "19.2" "17.1" "15.6" "15.5" "17.2" "20.0" "22.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1176127761844367310" "False" "High" "IsMasterProtein" "Q9H2G2" "STE20-like serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=SLK PE=1 SV=1" "0.000" "False" "11.471" "4" "4" "4" "4" "1235" "142.6" "5.15" "6.77" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12474" "9748" "ENSG00000065613" "SLK" "D3DRA0; D3DRA1; hsa:9748; O00211; Q6P1Z4; Q86WU7; Q86WW1; Q92603; Q9H2G2; Q9NQL0; Q9NQL1" "TAR syndrome" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle" "4" "0" "1.254" "1.003" "1.269" "1.598" "1.371" "1.510" "1.184" "1.212" "2.271" "46.1" "57.8" "46.2" "58.5" "73.6" "63.2" "69.6" "54.5" "55.9" "104.6" "" "" "" "" "" "" "" "" "" "" "27.6" "30.0" "25.6" "27.4" "34.1" "32.3" "32.4" "24.5" "30.3" "104.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2037005348220660879" "False" "High" "IsMasterProtein" "O00151" "PDZ and LIM domain protein 1 OS=Homo sapiens OX=9606 GN=PDLIM1 PE=1 SV=4" "0.000" "False" "11.439" "10" "3" "4" "3" "329" "36.0" "7.02" "10.19" "3" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595, Pf15936" "9124" "ENSG00000107438" "PDLIM1" "B2RBS6; hsa:9124; O00151; Q5VZH5; Q9BPZ9" "" "" "0" "0" "1.023" "0.907" "1.063" "1.160" "0.945" "1.187" "1.076" "1.047" "0.536" "215.2" "220.1" "195.2" "228.9" "249.6" "203.4" "255.5" "231.6" "225.3" "115.3" "" "" "" "" "" "" "" "" "" "" "128.8" "114.4" "108.1" "107.4" "115.7" "104.1" "118.8" "104.0" "122.2" "115.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5123694492544734526" "False" "High" "IsMasterProtein" "Q99417" "c-Myc-binding protein OS=Homo sapiens OX=9606 GN=MYCBP PE=1 SV=3" "0.000" "False" "11.425" "28" "3" "3" "3" "103" "12.0" "5.91" "8.87" "3" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "" "26292" "ENSG00000214114" "MYCBP" "B2R4N0; hsa:26292; Q5TA64; Q96HE2; Q99417" "Pathways affected in adenoid cystic carcinoma" "" "1" "0" "0.931" "0.896" "0.842" "1.022" "0.919" "1.231" "0.951" "0.877" "1.655" "191.0" "177.9" "171.1" "160.8" "195.1" "175.6" "235.1" "181.6" "167.5" "316.1" "" "" "" "" "" "" "" "" "" "" "114.3" "92.4" "94.7" "75.5" "90.5" "89.9" "109.3" "81.5" "90.9" "316.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3812741614734953835" "False" "High" "IsMasterProtein" "Q7L9L4" "MOB kinase activator 1B OS=Homo sapiens OX=9606 GN=MOB1B PE=1 SV=3" "0.000" "False" "11.422" "11" "2" "4" "2" "216" "25.1" "6.73" "12.41" "2" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03637" "92597" "ENSG00000173542" "MOB1B" "B2R8U6; B4DRY3; hsa:92597; Q7L9L4; Q8IY23" "Pleural mesothelioma" "Signaling by Hippo" "2" "0" "1.072" "0.816" "1.026" "1.194" "1.153" "0.979" "1.130" "1.044" "0.989" "157.5" "168.9" "128.6" "161.6" "188.0" "181.6" "154.2" "177.9" "164.4" "155.8" "" "" "" "" "" "" "" "" "" "" "94.3" "87.8" "71.2" "75.9" "87.1" "93.0" "71.7" "79.9" "89.2" "155.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-45443448741042807" "False" "High" "IsMasterProtein" "P24928" "DNA-directed RNA polymerase II subunit RPB1 OS=Homo sapiens OX=9606 GN=POLR2A PE=1 SV=2" "0.000" "False" "11.419" "3" "4" "4" "4" "1970" "217.0" "7.37" "8.60" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04990, Pf04992, Pf04997, Pf04998, Pf05000, Pf05001" "5430" "" "POLR2A" "A6NN93; B9EH88; hsa:5430; P24928; Q6NX41" "Pyrimidine metabolism; Eukaryotic transcription initiation; mRNA processing" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "44" "0" "1.031" "0.936" "1.115" "1.076" "1.125" "1.066" "0.779" "0.845" "3.150" "141.2" "145.5" "132.1" "157.4" "152.0" "158.8" "150.5" "110.0" "119.3" "444.8" "" "" "" "" "" "" "" "" "" "" "84.5" "75.6" "73.2" "73.9" "70.4" "81.3" "70.0" "49.4" "64.7" "444.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7073830227573610312" "False" "High" "IsMasterProtein" "Q9NR45" "Sialic acid synthase OS=Homo sapiens OX=9606 GN=NANS PE=1 SV=2" "0.000" "False" "11.411" "10" "3" "6" "3" "359" "40.3" "6.74" "20.62" "3" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf03102, Pf08666" "54187" "ENSG00000095380" "NANS" "B2RE98; Q8WUV9; Q9BWS6; Q9NR45; Q9NVD4" "Sialylation" "Sialic acid metabolism" "2" "0" "1.039" "1.115" "1.019" "1.055" "1.093" "0.985" "1.032" "1.066" "0.878" "454.8" "472.6" "507.1" "463.2" "479.9" "496.9" "447.7" "469.1" "484.8" "399.1" "" "" "" "" "" "" "" "" "" "" "272.1" "245.6" "280.8" "217.5" "222.4" "254.4" "208.2" "210.6" "263.0" "399.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5055182102876441761" "False" "High" "IsMasterProtein" "Q9BRT9" "DNA replication complex GINS protein SLD5 OS=Homo sapiens OX=9606 GN=GINS4 PE=1 SV=1" "0.000" "False" "11.404" "19" "3" "4" "3" "223" "26.0" "4.98" "8.08" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes" "nucleus;other cell component" "" "Pf05916, Pf16922" "84296" "ENSG00000147536" "GINS4" "B2R8H5; D3DSY0; hsa:84296; Q8N648; Q9BRT9" "" "Unwinding of DNA" "1" "0" "1.469" "1.336" "1.306" "1.890" "1.508" "1.877" "1.517" "1.427" "2.548" "17.4" "25.6" "23.2" "22.7" "32.9" "26.2" "32.7" "26.4" "24.8" "44.3" "" "" "" "" "" "" "" "" "" "" "10.4" "13.3" "12.9" "10.7" "15.2" "13.4" "15.2" "11.9" "13.5" "44.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8307908846177998742" "False" "High" "IsMasterProtein" "P20248" "Cyclin-A2 OS=Homo sapiens OX=9606 GN=CCNA2 PE=1 SV=2" "0.000" "False" "11.400" "8" "4" "8" "4" "432" "48.5" "6.54" "15.91" "4" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00134, Pf02984, Pf16500" "890" "ENSG00000145386" "CCNA2" "A8K7B6; hsa:890; P20248; Q2M3U6; Q4W5P4; Q6LER8" "AMP-activated protein kinase signaling; Cell cycle; Retinoblastoma gene in cancer; Photodynamic therapy-induced AP-1 survival signaling; IL-18 signaling pathway; Acute myeloid leukemia; NF1 copy number variation syndrome" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; Regulation of TP53 Degradation; SCF(Skp2)-mediated degradation of p27/p21; Regulation of TP53 Activity through Phosphorylation; G2 Phase; Telomere Extension By Telomerase; Regulation of APC/C activators between G1/S and early anaphase; Senescence-Associated Secretory Phenotype (SASP); Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; p53-Dependent G1 DNA Damage Response; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes" "27" "0" "0.975" "0.957" "0.832" "0.919" "0.842" "1.106" "1.234" "1.175" "0.854" "255.7" "249.3" "244.6" "212.7" "235.0" "215.5" "282.8" "315.6" "300.5" "218.4" "" "" "" "" "" "" "" "" "" "" "153.0" "129.6" "135.5" "99.9" "108.9" "110.3" "131.5" "141.7" "163.0" "218.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3292354779633865334" "False" "High" "IsMasterProtein" "A5YKK6" "CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=2" "0.000" "False" "11.399" "2" "5" "5" "5" "2376" "266.8" "7.11" "7.68" "5" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04054, Pf12842, Pf16415, Pf16417, Pf16418" "23019" "ENSG00000125107" "CNOT1" "A5YKK6; hsa:23019; Q68DX7; Q7Z3K2; Q8IWB8; Q8TB53; Q9BVZ6; Q9UFR8; Q9UI27; Q9Y2L0" "Ciliary landscape" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "4" "0" "0.869" "0.854" "0.963" "1.266" "1.475" "1.246" "0.820" "0.977" "5.310" "29.6" "25.7" "25.3" "28.5" "37.5" "43.7" "36.9" "24.3" "28.9" "157.2" "" "" "" "" "" "" "" "" "" "" "17.7" "13.4" "14.0" "13.4" "17.4" "22.4" "17.2" "10.9" "15.7" "157.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6721497203732723661" "False" "High" "IsMasterProtein" "P01591" "Immunoglobulin J chain OS=Homo sapiens OX=9606 GN=JCHAIN PE=1 SV=4" "0.000" "False" "11.393" "25" "4" "11" "4" "159" "18.1" "5.24" "33.12" "4" "cell organization and biogenesis;stress response;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding;other molecular function" "Pf15097" "3512" "ENSG00000132465" "JCHAIN" "hsa:3512; P01591" "" "Cell surface interactions at the vascular wall; Scavenging of heme from plasma" "2" "0" "0.984" "0.963" "1.014" "1.085" "1.109" "1.079" "1.166" "1.032" "0.637" "998.4" "982.1" "961.1" "1012.1" "1083.2" "1106.8" "1076.9" "1163.9" "1030.7" "636.1" "" "" "" "" "" "" "" "" "" "" "597.5" "510.3" "532.2" "475.1" "502.1" "566.6" "500.8" "522.5" "559.2" "636.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3876256361286906855" "False" "High" "IsMasterProtein" "P62269" "Small ribosomal subunit protein uS13 OS=Homo sapiens OX=9606 GN=RPS18 PE=1 SV=3" "0.000" "False" "11.371" "24" "4" "5" "4" "152" "17.7" "10.99" "11.50" "4" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00416" "6222" "ENSG00000096150; ENSG00000223367; ENSG00000226225; ENSG00000231500; ENSG00000235650" "RPS18" "hsa:6222; P25232; P62269; Q5SUJ3; Q6IPF8" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "0.956" "0.940" "1.005" "1.157" "1.073" "1.037" "0.744" "1.100" "2.132" "177.5" "169.8" "166.8" "178.3" "205.3" "190.4" "184.1" "132.0" "195.4" "378.5" "" "" "" "" "" "" "" "" "" "" "106.2" "88.2" "92.4" "83.7" "95.2" "97.5" "85.6" "59.3" "106.0" "378.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2858860997982508935" "False" "High" "IsMasterProtein" "Q99757" "Thioredoxin, mitochondrial OS=Homo sapiens OX=9606 GN=TXN2 PE=1 SV=2" "0.000" "False" "11.362" "16" "2" "3" "2" "166" "18.4" "8.29" "8.43" "2" "stress response;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00085" "25828" "ENSG00000100348" "TXN2" "hsa:25828; Q5JZA0; Q6FH60; Q99757; Q9UH29" "Oxidative stress response" "Detoxification of Reactive Oxygen Species; Degradation of cysteine and homocysteine" "3" "0" "0.771" "0.596" "1.115" "1.261" "0.805" "0.739" "1.336" "0.912" "0.832" "31.1" "24.0" "18.5" "34.7" "39.2" "25.0" "23.0" "41.5" "28.4" "25.9" "" "" "" "" "" "" "" "" "" "" "18.6" "12.5" "10.3" "16.3" "18.2" "12.8" "10.7" "18.6" "15.4" "25.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7969393992682693722" "False" "High" "IsMasterProtein" "Q9NUJ1" "Palmitoyl-protein thioesterase ABHD10, mitochondrial OS=Homo sapiens OX=9606 GN=ABHD10 PE=1 SV=1" "0.000" "False" "11.361" "12" "3" "7" "3" "306" "33.9" "8.57" "18.50" "3" "protein metabolism;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00561" "55347" "ENSG00000144827" "ABHD10" "B7Z6A8; C9IZX5; D3DN63; hsa:55347; Q8TCF9; Q9NUJ1" "" "Glucuronidation" "1" "0" "0.937" "0.997" "0.955" "0.926" "0.975" "0.911" "0.937" "0.972" "0.612" "232.7" "218.0" "232.1" "222.2" "215.5" "226.9" "212.0" "218.1" "226.2" "142.5" "" "" "" "" "" "" "" "" "" "" "139.3" "113.3" "128.5" "104.3" "99.9" "116.2" "98.6" "97.9" "122.7" "142.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400550207963658767" "False" "High" "IsMasterProtein" "Q8WWY3" "U4/U6 small nuclear ribonucleoprotein Prp31 OS=Homo sapiens OX=9606 GN=PRPF31 PE=1 SV=2" "0.000" "False" "11.361" "6" "3" "4" "3" "499" "55.4" "5.78" "9.37" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01798, Pf09785" "26121" "ENSG00000105618; ENSG00000274144; ENSG00000274651; ENSG00000274894; ENSG00000275117; ENSG00000275885; ENSG00000276421; ENSG00000277154; ENSG00000277707; ENSG00000277953" "PRPF31" "E7ESA8; F1T0A4; F1T0A5; hsa:26121; Q17RB4; Q8N7F9; Q8WWY3; Q9H271; Q9Y439" "" "mRNA Splicing - Major Pathway" "1" "0" "1.010" "1.032" "1.052" "0.995" "0.797" "1.224" "0.736" "0.977" "3.679" "133.3" "134.7" "137.5" "140.2" "132.6" "106.2" "163.2" "98.1" "130.3" "490.6" "" "" "" "" "" "" "" "" "" "" "79.8" "70.0" "76.2" "65.8" "61.5" "54.4" "75.9" "44.0" "70.7" "490.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9147063981897791280" "False" "High" "IsMasterProtein" "P04632" "Calpain small subunit 1 OS=Homo sapiens OX=9606 GN=CAPNS1 PE=1 SV=1" "0.000" "False" "11.357" "10" "2" "4" "2" "268" "28.3" "5.20" "10.80" "2" "protein metabolism;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "" "826" "ENSG00000126247" "CAPNS1" "A8K0P1; hsa:826; P04632; Q8WTX3; Q96EW0" "Integrin-mediated cell adhesion" "Formation of the cornified envelope; Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "4" "0" "1.011" "0.769" "1.128" "1.011" "0.945" "0.960" "1.194" "0.838" "1.312" "74.0" "74.8" "56.9" "83.4" "74.7" "69.9" "71.0" "88.3" "62.0" "97.0" "" "" "" "" "" "" "" "" "" "" "44.3" "38.9" "31.5" "39.2" "34.6" "35.8" "33.0" "39.6" "33.6" "97.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6553541234872075133" "False" "High" "IsMasterProtein" "Q8N488" "RING1 and YY1-binding protein OS=Homo sapiens OX=9606 GN=RYBP PE=1 SV=2" "0.000" "False" "11.350" "13" "1" "2" "1" "228" "24.8" "9.63" "6.89" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00641, Pf17219" "23429" "ENSG00000163602; ENSG00000281766" "RYBP" "hsa:23429; Q8N488; Q9P2W5; Q9UMW4" "" "Transcriptional Regulation by E2F6; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4429006779143257910" "False" "High" "IsMasterProtein" "Q14320" "Protein FAM50A OS=Homo sapiens OX=9606 GN=FAM50A PE=1 SV=2" "0.000" "False" "11.344" "12" "4" "4" "4" "339" "40.2" "6.83" "8.57" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf04921" "9130" "ENSG00000071859" "FAM50A" "A8KAQ4; B2R997; hsa:9130; Q14320; Q5HY37; Q6PJH5" "" "mRNA Splicing - Major Pathway" "1" "0" "1.049" "1.063" "1.157" "1.024" "1.137" "1.044" "0.949" "1.310" "2.872" "107.6" "112.9" "114.4" "124.5" "110.2" "122.3" "112.3" "102.1" "141.0" "309.0" "" "" "" "" "" "" "" "" "" "" "64.4" "58.7" "63.4" "58.4" "51.1" "62.6" "52.2" "45.9" "76.5" "309.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1595519607435168922" "False" "High" "IsMasterProtein" "P31942" "Heterogeneous nuclear ribonucleoprotein H3 OS=Homo sapiens OX=9606 GN=HNRNPH3 PE=1 SV=2" "0.000" "False" "11.338" "9" "3" "8" "2" "346" "36.9" "6.87" "18.33" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00076" "3189" "ENSG00000096746" "HNRNPH3" "A8K682; B3KRE1; hsa:3189; P31942; Q9BSX1; Q9NP53; Q9NP96; Q9NPA7; Q9NPI4; Q9UFU4; Q9Y4J5" "" "" "0" "0" "0.962" "0.849" "1.221" "0.936" "0.758" "0.981" "0.258" "1.038" "9.032" "44.8" "43.1" "38.0" "54.7" "41.9" "34.0" "43.9" "11.6" "46.5" "404.6" "" "" "" "" "" "" "" "" "" "" "26.8" "22.4" "21.1" "25.7" "19.4" "17.4" "20.4" "5.2" "25.2" "404.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9194587147899025830" "False" "High" "IsMasterProtein" "P30613" "Pyruvate kinase PKLR OS=Homo sapiens OX=9606 GN=PKLR PE=1 SV=2" "0.000" "False" "11.336" "4" "3" "25" "1" "574" "61.8" "7.74" "51.27" "3" "other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00224, Pf02887" "5313" "ENSG00000143627; ENSG00000262785" "PKLR" "hsa:5313; O75758; P11973; P30613" "Clear cell renal cell carcinoma pathways; Nonalcoholic fatty liver disease; 7q11.23 copy number variation syndrome; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "" "5" "0" "1.266" "1.232" "1.344" "1.158" "1.349" "1.162" "1.379" "1.077" "1.052" "110.8" "140.3" "136.6" "149.0" "128.3" "149.4" "128.8" "152.8" "119.3" "116.5" "" "" "" "" "" "" "" "" "" "" "66.3" "72.9" "75.6" "69.9" "59.5" "76.5" "59.9" "68.6" "64.7" "116.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-823041984393634953" "False" "High" "IsMasterProtein" "P25774" "Cathepsin S OS=Homo sapiens OX=9606 GN=CTSS PE=1 SV=3" "0.000" "False" "11.323" "10" "3" "4" "3" "331" "37.5" "8.34" "12.69" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00112, Pf08246" "1520" "ENSG00000163131" "CTSS" "B4DWC9; D3DV05; hsa:1520; P25774; Q5T5I0; Q6FHS5; Q9BUG3" "" "MHC class II antigen presentation; Neutrophil degranulation; Degradation of the extracellular matrix; Assembly of collagen fibrils and other multimeric structures; Trafficking and processing of endosomal TLR; Endosomal/Vacuolar pathway" "6" "0" "0.990" "0.974" "1.102" "1.136" "1.071" "1.040" "0.948" "1.027" "0.658" "241.4" "239.0" "235.2" "266.1" "274.2" "258.6" "251.0" "228.9" "248.0" "158.7" "" "" "" "" "" "" "" "" "" "" "144.5" "124.2" "130.2" "124.9" "127.1" "132.4" "116.7" "102.8" "134.6" "158.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7260357318160893257" "False" "High" "IsMasterProtein" "O75439" "Mitochondrial-processing peptidase subunit beta OS=Homo sapiens OX=9606 GN=PMPCB PE=1 SV=2" "0.000" "False" "11.318" "9" "4" "4" "4" "489" "54.3" "6.83" "8.63" "4" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion" "other molecular function" "Pf00675, Pf05193" "9512" "ENSG00000105819" "PMPCB" "hsa:9512; O60416; O75439; Q96FV4" "" "Mitochondrial protein import; Processing of SMDT1" "2" "0" "1.361" "0.966" "1.229" "1.313" "1.225" "1.250" "1.041" "1.463" "3.325" "54.2" "73.8" "52.4" "66.7" "71.2" "66.5" "67.8" "56.5" "79.4" "180.4" "" "" "" "" "" "" "" "" "" "" "32.5" "38.4" "29.0" "31.3" "33.0" "34.0" "31.5" "25.4" "43.1" "180.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "621637110793391590" "False" "High" "IsMasterProtein" "Q9BV79" "Enoyl-[acyl-carrier-protein] reductase, mitochondrial OS=Homo sapiens OX=9606 GN=MECR PE=1 SV=2" "0.000" "False" "11.314" "8" "3" "4" "3" "373" "40.4" "8.76" "12.56" "3" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00107, Pf08240" "51102" "ENSG00000116353" "MECR" "B3KT72; Q5SYU0; Q5SYU1; Q5SYU2; Q6IBU9; Q9BV79; Q9Y373" "Fatty acid biosynthesis; Mitochondrial fatty acid synthesis pathway" "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5453029631849906368" "False" "High" "IsMasterProtein" "Q9NRN7" "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase OS=Homo sapiens OX=9606 GN=AASDHPPT PE=1 SV=2" "0.000" "False" "11.313" "14" "4" "6" "4" "309" "35.8" "6.80" "14.98" "4" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf01648" "60496" "ENSG00000149313" "AASDHPPT" "B2R6D1; B4DDW7; hsa:60496; Q9C068; Q9NRN7; Q9P0Q3; Q9UG80; Q9Y389" "" "Vitamin B5 (pantothenate) metabolism" "1" "0" "0.920" "0.954" "0.950" "1.171" "1.026" "1.039" "0.714" "0.932" "1.455" "116.6" "107.3" "111.2" "110.7" "136.5" "119.6" "121.1" "83.2" "108.7" "169.7" "" "" "" "" "" "" "" "" "" "" "69.8" "55.7" "61.6" "52.0" "63.3" "61.2" "56.3" "37.4" "59.0" "169.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "765579875042607640" "False" "High" "IsMasterProtein" "Q15843" "NEDD8 OS=Homo sapiens OX=9606 GN=NEDD8 PE=1 SV=1" "0.000" "False" "11.297" "25" "2" "5" "2" "81" "9.1" "8.43" "12.60" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00240" "4738" "ENSG00000129559; ENSG00000285246" "NEDD8" "hsa:4738; Q15843; Q3SXN8; Q6LES6" "EGF/EGFR signaling pathway; 2q37 copy number variation syndrome" "UCH proteinases; Neddylation; Cargo recognition for clathrin-mediated endocytosis; Iron uptake and transport; TGF-beta receptor signaling activates SMADs" "7" "0" "0.908" "0.896" "0.869" "1.023" "0.903" "0.944" "1.006" "0.808" "0.513" "569.4" "517.1" "510.5" "494.9" "582.2" "514.3" "537.4" "573.0" "460.4" "291.8" "" "" "" "" "" "" "" "" "" "" "340.8" "268.7" "282.7" "232.4" "269.9" "263.3" "249.9" "257.2" "249.8" "291.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5625477449042213507" "False" "High" "IsMasterProtein" "P04179" "Superoxide dismutase [Mn], mitochondrial OS=Homo sapiens OX=9606 GN=SOD2 PE=1 SV=3" "0.000" "False" "11.277" "10" "4" "5" "4" "222" "24.7" "8.25" "14.27" "4" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00081, Pf02777" "6648" "ENSG00000291237" "SOD2" "B2R7R1; B3KUK2; B4DL20; B4E3K9; E1P5A9; P04179; P78434; Q16792; Q5TCM1; Q96EE6; Q9P2Z3" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; VEGFA-VEGFR2 signaling; Oxidative stress response" "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Detoxification of Reactive Oxygen Species; Transcriptional activation of mitochondrial biogenesis; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "10" "0" "0.895" "0.847" "0.943" "1.161" "1.015" "1.340" "1.191" "1.367" "0.506" "492.8" "440.9" "417.2" "464.6" "572.0" "500.4" "660.5" "587.0" "673.8" "249.5" "" "" "" "" "" "" "" "" "" "" "294.9" "229.1" "231.0" "218.1" "265.1" "256.2" "307.1" "263.5" "365.6" "249.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3953719107085229180" "False" "High" "IsMasterProtein" "Q9Y6K9" "NF-kappa-B essential modulator OS=Homo sapiens OX=9606 GN=IKBKG PE=1 SV=2" "0.000" "False" "11.269" "7" "3" "3" "3" "419" "48.2" "5.71" "9.56" "3" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf11577, Pf16516, Pf18414" "8517" "ENSG00000269335" "IKBKG" "hsa:8517; Q7LBY6; Q7Z7F1; Q9Y6K9" "Nucleotide-binding oligomerization domain (NOD) pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; ATM signaling in development and disease ; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Network map of SARS-CoV-2 signaling pathway; Acute myeloid leukemia; T-cell receptor signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway" "PKR-mediated signaling; Downstream TCR signaling; ER-Phagosome pathway; SARS-CoV-2 activates/modulates innate and adaptive immune responses; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; Ovarian tumor domain proteases; RIP-mediated NFkB activation via ZBP1; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; SUMOylation of immune response proteins" "76" "0" "1.056" "1.166" "0.908" "1.170" "1.181" "1.169" "1.050" "1.131" "0.942" "120.1" "126.9" "140.0" "109.0" "140.5" "141.8" "140.4" "126.1" "135.8" "113.1" "" "" "" "" "" "" "" "" "" "" "71.9" "65.9" "77.5" "51.2" "65.1" "72.6" "65.3" "56.6" "73.7" "113.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6962760823323839829" "False" "High" "IsMasterProtein" "O43681" "ATPase GET3 OS=Homo sapiens OX=9606 GN=GET3 PE=1 SV=2" "0.000" "False" "11.266" "9" "4" "16" "4" "348" "38.8" "4.91" "38.39" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf02374" "439" "ENSG00000198356" "GET3" "A6NHP8; A8K740; hsa:439; O43681; Q53FC6; Q92849" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "1.096" "0.917" "1.156" "1.196" "1.252" "1.008" "1.149" "1.069" "0.851" "546.8" "599.1" "501.2" "632.1" "653.7" "684.7" "551.2" "628.1" "584.5" "465.4" "" "" "" "" "" "" "" "" "" "" "327.2" "311.3" "277.5" "296.8" "303.0" "350.5" "256.3" "282.0" "317.1" "465.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-381937601164646059" "False" "High" "IsMasterProtein" "Q15257" "Serine/threonine-protein phosphatase 2A activator OS=Homo sapiens OX=9606 GN=PTPA PE=1 SV=3" "0.000" "False" "11.238" "13" "5" "9" "5" "358" "40.6" "5.94" "11.48" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf03095" "5524" "ENSG00000119383" "PTPA" "A2A347; A9IZU4; B4DXM4; hsa:5524; Q15257; Q15258; Q53GZ3; Q5TZQ2; Q9BUK1; Q9NNZ7; Q9NNZ8; Q9NNZ9" "Interleukin-11 signaling pathway; Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Wnt signaling pathway and pluripotency; Netrin-UNC5B signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "" "7" "0" "0.872" "0.896" "0.959" "1.008" "0.933" "0.927" "1.110" "0.924" "0.613" "216.4" "188.7" "193.9" "207.5" "218.2" "202.0" "200.7" "240.1" "200.0" "132.7" "" "" "" "" "" "" "" "" "" "" "129.5" "98.1" "107.4" "97.4" "101.1" "103.4" "93.3" "107.8" "108.5" "132.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1468233501590493710" "False" "High" "IsMasterProtein" "O60832" "H/ACA ribonucleoprotein complex subunit DKC1 OS=Homo sapiens OX=9606 GN=DKC1 PE=1 SV=3" "0.000" "False" "11.235" "8" "3" "5" "3" "514" "57.6" "9.42" "10.96" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01472, Pf01509, Pf08068, Pf16198" "1736" "ENSG00000130826" "DKC1" "F5BSB3; hsa:1736; O43845; O60832; Q96G67; Q9Y505" "" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "2" "0" "1.036" "1.151" "1.204" "1.161" "1.036" "1.251" "1.307" "1.279" "0.643" "131.0" "135.7" "150.8" "157.8" "152.2" "135.8" "163.9" "171.3" "167.6" "84.3" "" "" "" "" "" "" "" "" "" "" "78.4" "70.5" "83.5" "74.1" "70.5" "69.5" "76.2" "76.9" "90.9" "84.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-788718536083084523" "False" "High" "IsMasterProtein" "Q9ULR0" "Pre-mRNA-splicing factor ISY1 homolog OS=Homo sapiens OX=9606 GN=ISY1 PE=1 SV=3" "0.000" "False" "11.221" "8" "2" "3" "2" "285" "33.0" "5.17" "9.03" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf06246" "100534599; 57461" "ENSG00000240682" "ISY1" "hsa:100534599; hsa:57461; Q96IL2; Q9BT05; Q9ULR0" "" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; mRNA Splicing - Major Pathway" "5" "0" "1.297" "1.363" "2.121" "1.688" "1.195" "1.764" "1.400" "1.386" "0.809" "32.8" "42.6" "44.8" "69.7" "55.4" "39.3" "57.9" "46.0" "45.5" "26.6" "" "" "" "" "" "" "" "" "" "" "19.7" "22.1" "24.8" "32.7" "25.7" "20.1" "26.9" "20.7" "24.7" "26.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6978617919950458725" "False" "High" "IsMasterProtein" "O43592" "Exportin-T OS=Homo sapiens OX=9606 GN=XPOT PE=1 SV=2" "0.000" "False" "11.219" "5" "5" "5" "5" "962" "109.9" "5.39" "6.52" "5" "transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf19282" "11260" "ENSG00000184575" "XPOT" "A6NLH1; hsa:11260; O43592; O43784; Q8WUG2; Q9BVS7" "" "tRNA processing in the nucleus" "1" "0" "1.085" "1.007" "1.112" "1.035" "1.045" "0.955" "0.583" "1.052" "4.843" "64.0" "69.5" "64.5" "71.2" "66.3" "66.9" "61.2" "37.3" "67.3" "310.2" "" "" "" "" "" "" "" "" "" "" "38.3" "36.1" "35.7" "33.4" "30.7" "34.3" "28.4" "16.8" "36.5" "310.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2326963864063357056" "False" "High" "IsMasterProtein" "O95202" "Mitochondrial proton/calcium exchanger protein OS=Homo sapiens OX=9606 GN=LETM1 PE=1 SV=1" "0.000" "False" "11.204" "6" "4" "5" "4" "739" "83.3" "6.70" "13.55" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;translation activity;other molecular function" "Pf07766" "3954" "ENSG00000168924" "LETM1" "B4DED2; hsa:3954; O95202; Q9UF65" "4p16.3 copy number variation" "RHOG GTPase cycle; Mitochondrial calcium ion transport" "3" "0" "1.092" "0.995" "1.035" "1.129" "1.218" "1.277" "1.198" "1.052" "0.552" "201.3" "219.8" "200.2" "208.2" "227.2" "245.2" "257.1" "241.2" "211.8" "111.2" "" "" "" "" "" "" "" "" "" "" "120.4" "114.2" "110.9" "97.8" "105.3" "125.5" "119.5" "108.3" "114.9" "111.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1675638052339020088" "False" "High" "IsMasterProtein" "O75146" "Huntingtin-interacting protein 1-related protein OS=Homo sapiens OX=9606 GN=HIP1R PE=1 SV=2" "0.000" "False" "11.202" "4" "4" "5" "4" "1068" "119.3" "6.67" "6.45" "4" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf01608, Pf07651, Pf16515" "9026" "ENSG00000130787" "HIP1R" "A6NHQ6; hsa:9026; O75146; Q6NXG8; Q9UED9" "5q35 copy number variation" "Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis" "3" "0" "0.814" "0.906" "1.047" "0.893" "0.990" "1.115" "1.326" "0.933" "2.249" "17.5" "14.2" "15.8" "18.3" "15.6" "17.3" "19.5" "23.2" "16.3" "39.3" "" "" "" "" "" "" "" "" "" "" "10.5" "7.4" "8.8" "8.6" "7.2" "8.9" "9.1" "10.4" "8.8" "39.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5796509123597455273" "False" "High" "IsMasterProtein" "Q14558" "Phosphoribosyl pyrophosphate synthase-associated protein 1 OS=Homo sapiens OX=9606 GN=PRPSAP1 PE=1 SV=2" "0.000" "False" "11.199" "11" "3" "4" "3" "356" "39.4" "7.20" "12.38" "3" "other metabolic processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf13793, Pf14572" "5635" "ENSG00000161542" "PRPSAP1" "B2R6M4; hsa:5635; Q14558; Q96H06" "" "" "0" "0" "0.952" "0.850" "1.127" "0.911" "0.923" "0.994" "1.161" "1.034" "0.651" "83.9" "79.9" "71.4" "94.6" "76.4" "77.4" "83.4" "97.4" "86.7" "54.7" "" "" "" "" "" "" "" "" "" "" "50.2" "41.5" "39.5" "44.4" "35.4" "39.6" "38.8" "43.7" "47.1" "54.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4218486089971029806" "False" "High" "IsMasterProtein" "Q92608" "Dedicator of cytokinesis protein 2 OS=Homo sapiens OX=9606 GN=DOCK2 PE=1 SV=2" "0.000" "False" "11.192" "2" "3" "3" "3" "1830" "211.8" "6.87" "8.85" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf06920, Pf07653, Pf14429, Pf16172, Pf20421, Pf20422" "1794" "ENSG00000134516" "DOCK2" "hsa:1794; Q2M3I0; Q92608; Q96AK7" "Chemokine signaling pathway" "RAC1 GTPase cycle; Neutrophil degranulation; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; Factors involved in megakaryocyte development and platelet production; Nef and signal transduction" "8" "0" "1.035" "1.035" "0.990" "0.981" "1.169" "0.936" "0.302" "1.290" "10.161" "69.8" "72.3" "72.2" "69.1" "68.5" "81.7" "65.4" "21.1" "90.1" "709.6" "" "" "" "" "" "" "" "" "" "" "41.8" "37.6" "40.0" "32.5" "31.8" "41.8" "30.4" "9.5" "48.9" "709.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8980500697727064305" "False" "High" "IsMasterProtein" "O43815" "Striatin OS=Homo sapiens OX=9606 GN=STRN PE=1 SV=4" "0.000" "False" "11.191" "6" "4" "4" "4" "780" "86.1" "5.27" "10.87" "4" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00400, Pf08232" "6801" "ENSG00000115808" "STRN" "hsa:6801; O43815; Q3KP65; Q53TQ8; Q9NP38" "MET in type 1 papillary renal cell carcinoma" "Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins" "8" "0" "0.931" "0.942" "0.924" "0.999" "0.959" "0.951" "0.965" "0.990" "0.759" "273.1" "254.3" "257.2" "252.3" "272.9" "261.8" "259.6" "263.5" "270.3" "207.1" "" "" "" "" "" "" "" "" "" "" "163.4" "132.2" "142.4" "118.5" "126.5" "134.0" "120.7" "118.3" "146.6" "207.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3022549876159517749" "False" "High" "IsMasterProtein" "Q9H8W4" "Pleckstrin homology domain-containing family F member 2 OS=Homo sapiens OX=9606 GN=PLEKHF2 PE=1 SV=1" "0.000" "False" "11.186" "21" "3" "5" "3" "249" "27.8" "8.21" "12.67" "3" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00169, Pf01363" "79666" "ENSG00000175895" "PLEKHF2" "hsa:79666; Q9H8W4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4679234799158284053" "False" "High" "IsMasterProtein" "Q8N954" "G patch domain-containing protein 11 OS=Homo sapiens OX=9606 GN=GPATCH11 PE=1 SV=4" "0.000" "False" "11.183" "8" "2" "3" "2" "285" "33.3" "5.86" "8.80" "2" "" "other cell component" "nucleic acid binding activity" "Pf01585, Pf13821" "253635" "" "GPATCH11" "A0A0A0MSF9; A8K0D9; B7Z2G4; B8ZZ44; hsa:253635; Q8N954" "" "" "0" "0" "0.970" "1.053" "0.982" "1.151" "1.030" "0.914" "0.902" "0.921" "0.707" "135.9" "131.9" "143.1" "133.5" "156.4" "140.0" "124.2" "122.5" "125.2" "96.1" "" "" "" "" "" "" "" "" "" "" "81.3" "68.5" "79.3" "62.7" "72.5" "71.7" "57.8" "55.0" "67.9" "96.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2516150800733119915" "False" "High" "IsMasterProtein" "P55011" "Solute carrier family 12 member 2 OS=Homo sapiens OX=9606 GN=SLC12A2 PE=1 SV=1" "0.000" "False" "11.161" "3" "2" "2" "2" "1212" "131.4" "6.40" "8.45" "2" "cell-cell signaling;cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;other molecular function" "Pf00324, Pf03522, Pf08403" "6558" "ENSG00000064651" "SLC12A2" "hsa:6558; P55011; Q8N713; Q8WWH7" "Polycystic kidney disease pathway" "Cation-coupled Chloride cotransporters" "2" "0" "1.056" "1.176" "1.138" "1.245" "1.244" "1.136" "1.354" "1.028" "0.677" "95.2" "100.5" "111.9" "108.3" "118.5" "118.3" "108.1" "128.9" "97.9" "64.5" "" "" "" "" "" "" "" "" "" "" "57.0" "52.2" "62.0" "50.9" "54.9" "60.6" "50.3" "57.9" "53.1" "64.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1058361017873513588" "False" "High" "IsMasterProtein" "P63173" "Large ribosomal subunit protein eL38 OS=Homo sapiens OX=9606 GN=RPL38 PE=1 SV=2" "0.000" "False" "11.128" "47" "4" "6" "3" "70" "8.2" "10.10" "14.55" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01781" "6169" "ENSG00000172809" "RPL38" "B2R5A8; hsa:6169; P23411; P63173" "Mesodermal commitment pathway; Mesodermal commitment pathway; Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Response of EIF2AK4 (GCN2) to amino acid deficiency; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "16" "1" "1.069" "1.077" "0.986" "1.016" "1.067" "1.042" "1.133" "0.901" "0.623" "440.5" "471.0" "474.3" "434.5" "447.7" "470.0" "459.2" "499.0" "397.0" "274.3" "" "" "" "" "" "" "" "" "" "" "263.6" "244.7" "262.6" "204.0" "207.5" "240.6" "213.5" "224.0" "215.4" "274.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9218003044822153883" "False" "High" "IsMasterProtein" "O95881" "Thioredoxin domain-containing protein 12 OS=Homo sapiens OX=9606 GN=TXNDC12 PE=1 SV=1" "0.000" "False" "11.077" "22" "4" "6" "4" "172" "19.2" "5.40" "13.11" "4" "other biological processes" "ER/Golgi" "other molecular function" "Pf13899" "51060" "ENSG00000117862" "TXNDC12" "B3KQS0; hsa:51060; O95881; Q5T1T4; Q96H50" "" "" "0" "0" "1.110" "0.913" "1.356" "1.294" "1.125" "1.153" "1.046" "1.331" "1.333" "56.6" "62.8" "51.7" "76.8" "73.3" "63.7" "65.3" "59.2" "75.4" "75.5" "" "" "" "" "" "" "" "" "" "" "33.9" "32.7" "28.6" "36.1" "34.0" "32.6" "30.4" "26.6" "40.9" "75.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7499774936196670588" "False" "High" "IsMasterProtein" "A0A3B3IU46" "RNA guanine-N7 methyltransferase-activating subunit-like protein OS=Homo sapiens OX=9606 GN=RAMACL PE=3 SV=1" "0.000" "False" "11.040" "27" "3" "5" "3" "118" "14.4" "8.40" "17.06" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf15320" "" "ENSG00000235272" "RAMACL" "A0A3B3IU46" "" "" "0" "0" "0.994" "0.978" "0.877" "0.958" "1.020" "0.964" "1.052" "0.950" "0.455" "484.1" "481.2" "473.7" "424.7" "463.6" "493.5" "466.7" "509.3" "459.9" "220.3" "" "" "" "" "" "" "" "" "" "" "289.7" "250.1" "262.3" "199.4" "214.9" "252.7" "217.0" "228.6" "249.5" "220.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5898955459380036323" "False" "High" "IsMasterProtein" "Q05048" "Cleavage stimulation factor subunit 1 OS=Homo sapiens OX=9606 GN=CSTF1 PE=1 SV=1" "0.000" "False" "11.034" "7" "3" "4" "3" "431" "48.3" "6.58" "11.45" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00400, Pf16699" "1477" "ENSG00000101138" "CSTF1" "hsa:1477; Q05048; Q5QPD8" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "0.951" "0.937" "0.922" "0.964" "0.927" "0.967" "0.833" "0.914" "1.144" "386.8" "367.7" "362.3" "356.7" "372.9" "358.6" "374.0" "322.2" "353.4" "442.6" "" "" "" "" "" "" "" "" "" "" "231.5" "191.1" "200.7" "167.5" "172.8" "183.6" "173.9" "144.7" "191.7" "442.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6527665309278316816" "False" "High" "IsMasterProtein" "O15145" "Actin-related protein 2/3 complex subunit 3 OS=Homo sapiens OX=9606 GN=ARPC3 PE=1 SV=3" "0.000" "False" "11.031" "14" "3" "23" "3" "178" "20.5" "8.59" "50.23" "3" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf04062" "10094" "ENSG00000111229" "ARPC3" "hsa:10094; O00554; O15145" "Pathogenic Escherichia coli infection" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "6" "0" "1.038" "0.982" "1.023" "1.005" "0.954" "1.064" "1.047" "0.954" "0.712" "1713.8" "1778.8" "1682.2" "1752.7" "1722.7" "1635.7" "1823.9" "1794.9" "1635.8" "1221.1" "" "" "" "" "" "" "" "" "" "" "1025.6" "924.4" "931.6" "822.8" "798.5" "837.3" "848.1" "805.8" "887.5" "1221.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "598569642609282214" "False" "High" "IsMasterProtein" "Q9BRS2" "Serine/threonine-protein kinase RIO1 OS=Homo sapiens OX=9606 GN=RIOK1 PE=1 SV=2" "0.000" "False" "11.006" "6" "3" "4" "3" "568" "65.5" "6.19" "9.31" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01163" "83732" "ENSG00000124784" "RIOK1" "B2RB28; Q8NDC8; Q96NV9; Q9BRS2" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.095" "1.106" "1.032" "1.152" "1.116" "0.928" "1.106" "0.944" "0.779" "215.0" "235.4" "237.8" "221.9" "247.7" "239.8" "199.5" "237.8" "203.0" "167.4" "" "" "" "" "" "" "" "" "" "" "128.7" "122.4" "131.7" "104.2" "114.8" "122.8" "92.7" "106.8" "110.2" "167.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8225336690214534054" "False" "High" "IsMasterProtein" "O43768" "Alpha-endosulfine OS=Homo sapiens OX=9606 GN=ENSA PE=1 SV=1" "0.000" "False" "11.003" "22" "3" "6" "2" "121" "13.4" "7.24" "18.29" "3" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf04667" "2029" "ENSG00000143420" "ENSA" "A8K1Z9; E9PB69; hsa:2029; O43768; Q5T5H2; Q68D48; Q6FHW0; Q6IAM4; Q6NUL2; Q6VUC6; Q6VUC7; Q6VUC8; Q6VUC9; Q6VUD0; Q6VUD1; Q9NRZ0" "" "MASTL Facilitates Mitotic Progression" "1" "1" "0.870" "0.823" "0.812" "0.766" "0.886" "0.861" "0.813" "0.757" "0.528" "1171.7" "1019.8" "964.5" "951.4" "897.2" "1037.9" "1009.3" "952.3" "886.8" "618.7" "" "" "" "" "" "" "" "" "" "" "701.2" "530.0" "534.1" "446.7" "415.9" "531.3" "469.3" "427.5" "481.1" "618.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3645624783218300571" "False" "High" "IsMasterProtein" "Q96CG3" "TRAF-interacting protein with FHA domain-containing protein A OS=Homo sapiens OX=9606 GN=TIFA PE=1 SV=1" "0.000" "False" "11.003" "18" "4" "4" "4" "184" "21.4" "5.11" "11.50" "4" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf00498" "92610" "ENSG00000145365" "TIFA" "hsa:92610; Q96CG3" "Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway" "TAK1-dependent IKK and NF-kappa-B activation ; Alpha-protein kinase 1 signaling pathway" "4" "0" "1.047" "1.075" "1.101" "1.072" "0.996" "0.880" "0.969" "1.004" "1.205" "530.7" "555.7" "570.3" "584.4" "568.7" "528.5" "466.9" "514.5" "532.9" "639.5" "" "" "" "" "" "" "" "" "" "" "317.6" "288.8" "315.8" "274.4" "263.6" "270.5" "217.1" "231.0" "289.1" "639.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6144698658960758490" "False" "High" "IsMasterProtein" "Q8IXB1" "DnaJ homolog subfamily C member 10 OS=Homo sapiens OX=9606 GN=DNAJC10 PE=1 SV=2" "0.000" "False" "11.002" "7" "5" "10" "5" "793" "91.0" "7.18" "14.03" "5" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi" "other molecular function" "Pf00085, Pf00226" "54431" "ENSG00000077232" "DNAJC10" "hsa:54431; Q17RJ6; Q3B7W8; Q4ZG06; Q53QT7; Q6UWZ6; Q86T61; Q8IXB1; Q8NC82; Q8TD87; Q96K38; Q96K44; Q96K54; Q9NSY6" "" "" "0" "0" "1.139" "1.063" "1.135" "1.184" "1.101" "0.997" "1.240" "1.164" "1.444" "97.4" "111.0" "103.6" "110.6" "115.4" "107.2" "97.2" "120.8" "113.4" "140.7" "" "" "" "" "" "" "" "" "" "" "58.3" "57.7" "57.3" "51.9" "53.5" "54.9" "45.2" "54.2" "61.5" "140.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1948435004993003441" "False" "High" "IsMasterProtein" "P52594" "Arf-GAP domain and FG repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=AGFG1 PE=1 SV=2" "0.000" "False" "10.976" "8" "3" "4" "3" "562" "58.2" "8.63" "12.76" "3" "cell organization and biogenesis;other metabolic processes;transport" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01412" "3267" "ENSG00000173744" "AGFG1" "B3KUL1; E9PHX7; hsa:3267; P52594; Q15277; Q4VAS0; Q4VAS1; Q4VAS3; Q53QT8; Q53R11" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "1.122" "1.058" "1.103" "0.939" "1.109" "0.989" "1.126" "0.969" "1.048" "156.6" "175.6" "165.6" "172.6" "147.1" "173.6" "154.9" "176.4" "151.8" "164.1" "" "" "" "" "" "" "" "" "" "" "93.7" "91.3" "91.7" "81.0" "68.2" "88.9" "72.0" "79.2" "82.3" "164.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4653311583040189549" "False" "High" "IsMasterProtein" "Q9H2P9" "Diphthine methyl ester synthase OS=Homo sapiens OX=9606 GN=DPH5 PE=1 SV=2" "0.000" "False" "10.952" "16" "4" "6" "4" "285" "31.6" "5.31" "15.15" "4" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00590" "51611" "ENSG00000117543" "DPH5" "A8JZY6; D3DT62; hsa:51611; Q9H2P9; Q9P017; Q9P0I4; Q9Y319" "" "Synthesis of diphthamide-EEF2" "1" "0" "1.067" "0.965" "1.006" "1.023" "1.052" "0.959" "0.963" "0.926" "0.726" "427.5" "456.3" "412.7" "430.0" "437.3" "449.8" "410.1" "411.7" "395.9" "310.4" "" "" "" "" "" "" "" "" "" "" "255.9" "237.1" "228.5" "201.9" "202.7" "230.2" "190.7" "184.8" "214.8" "310.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1549161421235899806" "False" "High" "IsMasterProtein" "Q96EH3" "Mitochondrial assembly of ribosomal large subunit protein 1 OS=Homo sapiens OX=9606 GN=MALSU1 PE=1 SV=1" "0.000" "False" "10.932" "18" "3" "4" "3" "234" "26.2" "5.49" "6.59" "3" "other biological processes" "cytosol;mitochondrion" "translation activity" "Pf02410" "115416" "ENSG00000156928" "MALSU1" "A4D154; hsa:115416; Q96EH3" "" "" "0" "0" "1.194" "1.195" "1.520" "1.575" "1.274" "1.090" "1.511" "1.522" "1.092" "53.3" "63.6" "63.6" "81.0" "83.9" "67.9" "58.1" "80.5" "81.1" "58.2" "" "" "" "" "" "" "" "" "" "" "31.9" "33.1" "35.2" "38.0" "38.9" "34.7" "27.0" "36.1" "44.0" "58.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8013273140133158732" "False" "High" "IsMasterProtein" "Q9H3P7" "Golgi resident protein GCP60 OS=Homo sapiens OX=9606 GN=ACBD3 PE=1 SV=4" "0.000" "False" "10.910" "8" "3" "5" "3" "528" "60.6" "5.06" "15.51" "3" "other metabolic processes" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf00887, Pf13897" "64746" "ENSG00000182827" "ACBD3" "B2RB29; hsa:64746; Q5VTJ0; Q6P9F1; Q8IZC5; Q8N4D6; Q9H3P7; Q9H6U3" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "1.332" "1.383" "1.263" "1.619" "1.422" "0.948" "1.076" "1.532" "3.861" "42.4" "56.5" "58.7" "53.6" "68.7" "60.4" "40.2" "45.7" "65.0" "163.8" "" "" "" "" "" "" "" "" "" "" "25.4" "29.4" "32.5" "25.2" "31.9" "30.9" "18.7" "20.5" "35.3" "163.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3142486401368971215" "False" "High" "IsMasterProtein" "Q3YEC7" "Rab-like protein 6 OS=Homo sapiens OX=9606 GN=RABL6 PE=1 SV=2" "0.000" "False" "10.904" "6" "4" "4" "4" "729" "79.5" "5.22" "9.21" "4" "" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08477" "55684" "ENSG00000196642" "RABL6" "A8QVZ7; A8QVZ8; C6K8I4; C6K8I5; hsa:55684; Q3YEC7; Q4F968; Q5T5R7; Q8IWK1; Q8TCL4; Q8WU94; Q96SR8; Q9BU21; Q9H935" "" "" "0" "0" "1.035" "0.891" "1.069" "1.149" "1.313" "1.263" "1.319" "1.025" "0.817" "56.1" "58.1" "50.0" "60.0" "64.5" "73.7" "70.9" "74.0" "57.5" "45.8" "" "" "" "" "" "" "" "" "" "" "33.6" "30.2" "27.7" "28.2" "29.9" "37.7" "32.9" "33.2" "31.2" "45.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2846560637843554470" "False" "High" "IsMasterProtein" "O14579" "Coatomer subunit epsilon OS=Homo sapiens OX=9606 GN=COPE PE=1 SV=3" "0.000" "False" "10.899" "11" "3" "6" "3" "308" "34.5" "5.12" "15.47" "3" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus" "other molecular function" "Pf04733" "11316" "ENSG00000105669" "COPE" "A6NE29; A6NKA3; hsa:11316; O14579; O76097; Q6IBB8; Q9UGP6" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "0.916" "0.985" "1.005" "1.210" "1.026" "0.908" "0.935" "1.074" "1.228" "159.7" "146.2" "157.3" "160.5" "193.3" "163.9" "145.0" "149.4" "171.5" "196.1" "" "" "" "" "" "" "" "" "" "" "95.6" "76.0" "87.1" "75.4" "89.6" "83.9" "67.4" "67.1" "93.0" "196.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5422158606125759469" "False" "High" "IsMasterProtein" "Q86U42" "Polyadenylate-binding protein 2 OS=Homo sapiens OX=9606 GN=PABPN1 PE=1 SV=3" "0.000" "False" "10.889" "8" "3" "6" "3" "306" "32.7" "5.06" "18.56" "3" "RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "8106" "ENSG00000100836" "PABPN1" "D3DS49; hsa:8106; O43484; Q86U42" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "7" "0" "1.054" "1.168" "1.110" "1.118" "1.031" "1.087" "0.943" "1.091" "2.388" "726.6" "766.2" "848.4" "806.1" "812.5" "748.9" "789.8" "685.4" "793.0" "1734.8" "" "" "" "" "" "" "" "" "" "" "434.8" "398.1" "469.8" "378.5" "376.6" "383.4" "367.2" "307.7" "430.2" "1734.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5455074280924099638" "False" "High" "IsMasterProtein" "Q15554" "Telomeric repeat-binding factor 2 OS=Homo sapiens OX=9606 GN=TERF2 PE=1 SV=3" "0.000" "False" "10.883" "7" "3" "3" "3" "542" "59.6" "9.35" "7.83" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf08558, Pf16772" "7014" "ENSG00000132604" "TERF2" "hsa:7014; Q15554" "Hematopoietic stem cell gene regulation by GABP alpha/beta complex; DNA repair pathways, full network; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "Meiotic synapsis; Telomere Extension By Telomerase; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Removal of the Flap Intermediate from the C-strand" "17" "0" "1.169" "1.342" "1.243" "1.310" "1.220" "1.632" "1.284" "1.302" "4.471" "27.9" "32.6" "37.4" "34.7" "36.5" "34.0" "45.5" "35.8" "36.3" "124.6" "" "" "" "" "" "" "" "" "" "" "16.7" "16.9" "20.7" "16.3" "16.9" "17.4" "21.1" "16.1" "19.7" "124.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "172904709922305924" "False" "High" "IsMasterProtein" "Q5UIP0" "Telomere-associated protein RIF1 OS=Homo sapiens OX=9606 GN=RIF1 PE=1 SV=2" "0.000" "False" "10.877" "2" "4" "4" "4" "2472" "274.3" "5.52" "4.64" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "" "Pf12231" "55183" "ENSG00000080345" "RIF1" "A6NC27; C9JBR1; hsa:55183; Q5H9R3; Q5UIP0; Q5UIP2; Q66YK6; Q6PRU2; Q8TE94; Q99772; Q9H830; Q9H9B9; Q9NVP5; Q9Y4R4" "ATM signaling in development and disease ; 10q11.21q11.23 copy number variation syndrome" "Nonhomologous End-Joining (NHEJ)" "3" "0" "1.335" "0.943" "0.913" "1.223" "1.183" "1.457" "0.979" "1.290" "4.632" "60.6" "80.9" "57.2" "55.3" "74.1" "71.7" "88.3" "59.3" "78.2" "280.8" "" "" "" "" "" "" "" "" "" "" "36.3" "42.1" "31.7" "26.0" "34.4" "36.7" "41.1" "26.6" "42.4" "280.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4736314326613788604" "False" "High" "IsMasterProtein" "P62277" "Small ribosomal subunit protein uS15 OS=Homo sapiens OX=9606 GN=RPS13 PE=1 SV=2" "0.000" "False" "10.865" "26" "4" "4" "4" "151" "17.2" "10.54" "10.39" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00312, Pf08069" "6207" "ENSG00000110700" "RPS13" "B2R549; hsa:6207; P19116; P62277; Q02546; Q29200; Q498Y0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.866" "0.887" "1.000" "1.100" "0.859" "0.899" "1.006" "1.077" "0.870" "86.9" "75.2" "77.1" "86.9" "95.6" "74.6" "78.1" "87.4" "93.6" "75.6" "" "" "" "" "" "" "" "" "" "" "52.0" "39.1" "42.7" "40.8" "44.3" "38.2" "36.3" "39.2" "50.8" "75.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7462981975688921114" "False" "High" "IsMasterProtein" "Q7Z2T5" "TRMT1-like protein OS=Homo sapiens OX=9606 GN=TRMT1L PE=1 SV=2" "0.000" "False" "10.862" "4" "2" "3" "2" "733" "81.7" "7.88" "8.76" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02005" "81627" "ENSG00000121486" "TRMT1L" "hsa:81627; Q5TEN0; Q6ZMX0; Q7Z2T5; Q8IWH5; Q8NC68; Q9BZQ1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5036533815918111608" "False" "High" "IsMasterProtein" "Q9NP72" "Ras-related protein Rab-18 OS=Homo sapiens OX=9606 GN=RAB18 PE=1 SV=1" "0.000" "False" "10.861" "12" "2" "3" "2" "206" "23.0" "5.24" "9.08" "2" "cell organization and biogenesis;transport;developmental processes;signal transduction" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "22931" "ENSG00000099246" "RAB18" "B3KMC7; B7Z333; D3DRW1; hsa:22931; Q53FX8; Q56UN9; Q6FIH1; Q9NP72" "" "Neutrophil degranulation; RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic" "4" "0" "1.303" "1.148" "1.443" "1.416" "1.475" "1.208" "1.471" "1.345" "1.148" "48.5" "63.2" "55.6" "69.9" "68.7" "71.5" "58.6" "71.3" "65.2" "55.7" "" "" "" "" "" "" "" "" "" "" "29.0" "32.8" "30.8" "32.8" "31.8" "36.6" "27.2" "32.0" "35.4" "55.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1703725255333180782" "False" "High" "IsMasterProtein" "O14530" "Thioredoxin domain-containing protein 9 OS=Homo sapiens OX=9606 GN=TXNDC9 PE=1 SV=2" "0.000" "False" "10.860" "16" "4" "5" "4" "226" "26.5" "5.88" "12.60" "4" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf00085" "10190" "ENSG00000115514" "TXNDC9" "B2R9G8; D3DVI4; hsa:10190; O14530; Q53HG4; Q53RV8; Q6NSF5; Q8TB70; Q9BRU6" "" "" "0" "0" "1.475" "1.154" "1.230" "1.360" "0.981" "1.254" "1.319" "1.211" "2.350" "96.7" "142.6" "111.6" "118.9" "131.5" "94.8" "121.2" "127.5" "117.0" "227.2" "" "" "" "" "" "" "" "" "" "" "57.9" "74.1" "61.8" "55.8" "60.9" "48.6" "56.4" "57.3" "63.5" "227.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8788439396421035672" "False" "High" "IsMasterProtein" "Q92621" "Nuclear pore complex protein Nup205 OS=Homo sapiens OX=9606 GN=NUP205 PE=1 SV=3" "0.000" "False" "10.831" "1" "2" "3" "2" "2012" "227.8" "6.19" "7.34" "2" "cell organization and biogenesis;transport" "other membranes;cytosol;nucleus" "other molecular function" "Pf11894" "23165" "ENSG00000155561" "NUP205" "A6H8X3; hsa:23165; Q86YC1; Q92621" "" "Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "29" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3875322263221301035" "False" "High" "IsMasterProtein" "P51553" "Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3G PE=1 SV=1" "0.000" "False" "10.787" "10" "3" "3" "3" "393" "42.8" "8.50" "11.68" "3" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00180" "3421" "ENSG00000067829" "IDH3G" "E9PDD5; hsa:3421; P51553; Q9BUU5" "TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein import" "3" "0" "1.087" "1.030" "0.989" "1.089" "1.049" "1.068" "1.062" "0.983" "1.105" "250.7" "272.5" "258.1" "248.0" "272.9" "263.0" "267.8" "266.2" "246.3" "276.9" "" "" "" "" "" "" "" "" "" "" "150.0" "141.6" "142.9" "116.4" "126.5" "134.6" "124.5" "119.5" "133.6" "276.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7173448255119182363" "False" "High" "IsMasterProtein" "P27635" "Large ribosomal subunit protein uL16 OS=Homo sapiens OX=9606 GN=RPL10 PE=1 SV=5" "0.000" "False" "10.765" "20" "4" "7" "4" "214" "24.6" "10.08" "7.75" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00252" "6134" "ENSG00000147403" "RPL10" "A3KQT0; D3DWW6; hsa:6134; P27635; Q16470; Q2HXT7; Q53FH7; Q6FGN8; Q8TDA5" "Cytoplasmic ribosomal proteins; Primary ovarian insufficiency" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Response of EIF2AK4 (GCN2) to amino acid deficiency; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination" "15" "0" "1.012" "1.078" "1.187" "1.107" "1.061" "1.067" "1.357" "1.240" "1.041" "108.3" "109.6" "116.7" "128.5" "119.9" "114.9" "115.5" "146.9" "134.2" "112.7" "" "" "" "" "" "" "" "" "" "" "64.8" "56.9" "64.6" "60.3" "55.6" "58.8" "53.7" "65.9" "72.8" "112.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4258123771778816743" "False" "High" "IsMasterProtein" "P55265" "Double-stranded RNA-specific adenosine deaminase OS=Homo sapiens OX=9606 GN=ADAR PE=1 SV=4" "0.000" "False" "10.759" "3" "3" "3" "3" "1226" "136.0" "8.65" "7.65" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf02137, Pf02295" "103" "ENSG00000160710" "ADAR" "B1AQQ9; B1AQR0; D3DV76; hsa:103; O15223; O43859; O43860; P55265; Q9BYM3; Q9BYM4" "Measles virus infection; Cytosolic DNA-sensing pathway" "Interferon alpha/beta signaling; PKR-mediated signaling; C6 deamination of adenosine; Formation of editosomes by ADAR proteins" "6" "0" "0.992" "1.084" "1.015" "1.121" "1.138" "1.173" "0.303" "1.259" "11.728" "74.7" "74.1" "81.0" "75.8" "83.8" "85.1" "87.7" "22.6" "94.1" "876.4" "" "" "" "" "" "" "" "" "" "" "44.7" "38.5" "44.9" "35.6" "38.8" "43.5" "40.8" "10.2" "51.0" "876.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7629412907813045008" "False" "High" "IsMasterProtein" "Q14997" "Proteasome activator complex subunit 4 OS=Homo sapiens OX=9606 GN=PSME4 PE=1 SV=2" "0.000" "False" "10.750" "2" "4" "4" "4" "1843" "211.2" "6.90" "9.68" "4" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf11919, Pf16507" "23198" "ENSG00000068878" "PSME4" "hsa:23198; Q14997; Q1XBG4; Q1XBG5; Q1XBG6; Q2M1Z0; Q6IPR2; Q86XF8" "" "Regulation of expression of SLITs and ROBOs; UCH proteinases; Ub-specific processing proteases; Downstream TCR signaling; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway" "52" "0" "1.312" "1.289" "1.671" "1.854" "1.639" "1.771" "1.261" "1.468" "4.591" "32.7" "42.9" "42.1" "54.6" "60.6" "53.6" "57.8" "41.2" "48.0" "150.0" "" "" "" "" "" "" "" "" "" "" "19.6" "22.3" "23.3" "25.6" "28.1" "27.4" "26.9" "18.5" "26.0" "150.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5788074156748143009" "False" "High" "IsMasterProtein" "Q96IJ6" "Mannose-1-phosphate guanyltransferase alpha OS=Homo sapiens OX=9606 GN=GMPPA PE=1 SV=1" "0.000" "False" "10.732" "9" "4" "5" "4" "420" "46.3" "7.21" "7.33" "4" "other metabolic processes" "other cell component" "other molecular function" "Pf00132, Pf00483" "29926" "ENSG00000144591" "GMPPA" "A6NJ74; A8K3Q6; B3KMT4; hsa:29926; Q53GI0; Q96IJ6; Q9NWC3; Q9Y5P5" "N-glycan biosynthesis" "Synthesis of GDP-mannose" "2" "0" "0.947" "1.175" "1.265" "1.249" "1.174" "1.197" "1.303" "1.150" "1.190" "78.3" "74.2" "92.0" "99.0" "97.8" "91.9" "93.7" "102.0" "90.1" "93.2" "" "" "" "" "" "" "" "" "" "" "46.9" "38.5" "50.9" "46.5" "45.3" "47.1" "43.6" "45.8" "48.9" "93.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5673730343044781282" "False" "High" "IsMasterProtein" "Q96HS1" "Serine/threonine-protein phosphatase PGAM5, mitochondrial OS=Homo sapiens OX=9606 GN=PGAM5 PE=1 SV=2" "0.000" "False" "10.715" "16" "5" "9" "5" "289" "32.0" "8.68" "18.87" "5" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "enzyme regulator activity;other molecular function" "Pf00300" "192111" "ENSG00000247077" "PGAM5" "A9LN06; C9IZY7; hsa:192111; Q96HS1; Q96JB0" "NRF2-ARE regulation" "" "1" "0" "1.126" "0.983" "1.152" "1.099" "1.179" "0.961" "1.113" "1.075" "0.864" "474.0" "533.7" "465.7" "546.0" "521.0" "559.0" "455.5" "527.6" "509.5" "409.3" "" "" "" "" "" "" "" "" "" "" "283.6" "277.4" "257.9" "256.3" "241.5" "286.2" "211.8" "236.9" "276.4" "409.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8494037614751494800" "False" "High" "IsMasterProtein" "O94900" "Thymocyte selection-associated high mobility group box protein TOX OS=Homo sapiens OX=9606 GN=TOX PE=1 SV=3" "0.000" "False" "10.714" "7" "3" "5" "3" "526" "57.5" "7.33" "11.54" "3" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00505" "9760" "ENSG00000198846" "TOX" "hsa:9760; O94900; Q96AV5" "Mesodermal commitment pathway; Development and heterogeneity of the ILC family; Orexin receptor pathway" "" "3" "0" "1.082" "1.111" "1.046" "1.006" "0.973" "1.017" "0.934" "1.068" "1.287" "125.4" "135.7" "139.4" "131.2" "126.1" "122.0" "127.5" "117.2" "133.9" "161.4" "" "" "" "" "" "" "" "" "" "" "75.0" "70.5" "77.2" "61.6" "58.5" "62.5" "59.3" "52.6" "72.6" "161.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2494116660910275017" "False" "High" "IsMasterProtein" "Q9H814" "Phosphorylated adapter RNA export protein OS=Homo sapiens OX=9606 GN=PHAX PE=1 SV=1" "0.000" "False" "10.702" "8" "3" "5" "3" "394" "44.4" "5.40" "13.18" "3" "transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10258" "51808" "ENSG00000164902" "PHAX" "hsa:51808; Q9H814; Q9H8W1" "" "RNA polymerase II transcribes snRNA genes; snRNP Assembly" "2" "0" "1.009" "1.058" "1.160" "1.189" "1.117" "1.127" "1.194" "1.204" "1.218" "183.0" "184.6" "193.5" "212.2" "217.5" "204.3" "206.2" "218.4" "220.4" "222.8" "" "" "" "" "" "" "" "" "" "" "109.5" "95.9" "107.2" "99.6" "100.8" "104.6" "95.9" "98.0" "119.6" "222.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2447610796588384838" "False" "High" "IsMasterProtein" "Q96SZ5" "2-aminoethanethiol dioxygenase OS=Homo sapiens OX=9606 GN=ADO PE=1 SV=2" "0.000" "False" "10.701" "13" "4" "4" "4" "270" "29.7" "6.04" "8.20" "4" "stress response" "cytosol" "other molecular function" "Pf07847" "84890" "ENSG00000181915" "ADO" "B1AL29; hsa:84890; Q96SZ5" "" "Degradation of cysteine and homocysteine" "1" "0" "1.349" "1.411" "1.058" "0.709" "0.957" "1.188" "0.963" "1.371" "0.841" "25.2" "34.0" "35.6" "26.7" "17.9" "24.1" "30.0" "24.3" "34.6" "21.2" "" "" "" "" "" "" "" "" "" "" "15.1" "17.7" "19.7" "12.5" "8.3" "12.4" "13.9" "10.9" "18.8" "21.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7463306019950863991" "False" "High" "IsMasterProtein" "O60784" "Target of Myb1 membrane trafficking protein OS=Homo sapiens OX=9606 GN=TOM1 PE=1 SV=2" "0.000" "False" "10.696" "7" "3" "4" "3" "492" "53.8" "4.70" "6.51" "3" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00790, Pf03127" "10043" "ENSG00000100284" "TOM1" "B4DEL9; B4DNA1; hsa:10043; O60784; Q5TIJ6; Q86X74" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8597337933688242360" "False" "High" "IsMasterProtein" "P84243" "Histone H3.3 OS=Homo sapiens OX=9606 GN=H3-3B PE=1 SV=2" "0.000" "False" "10.694" "24" "4" "16" "2" "136" "15.3" "11.27" "49.16" "4" "cell organization and biogenesis;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "3020; 3021" "ENSG00000132475; ENSG00000163041" "H3-3A; H3-3B" "hsa:3020; hsa:3021; P06351; P33155; P84243; Q5VV55; Q5VV56; Q66I33; Q9V3W4" "Gastric cancer network 1; Histone modifications; Tumor suppressor activity of SMARCB1; Ciliary landscape; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; DYRK1A involvement regarding cell proliferation in brain development; 4p16.3 copy number variation; 5q35 copy number variation" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Amyloid fiber formation; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Factors involved in megakaryocyte development and platelet production; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "36" "2" "0.830" "0.924" "0.852" "0.870" "0.854" "0.796" "0.710" "0.809" "0.952" "1346.6" "1117.5" "1244.6" "1147.9" "1171.2" "1150.4" "1072.0" "956.6" "1088.8" "1281.4" "" "" "" "" "" "" "" "" "" "" "805.9" "580.7" "689.2" "538.9" "542.9" "588.9" "498.4" "429.5" "590.7" "1281.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-765021547925747573" "False" "High" "IsMasterProtein" "P49366" "Deoxyhypusine synthase OS=Homo sapiens OX=9606 GN=DHPS PE=1 SV=1" "0.000" "False" "10.691" "9" "3" "4" "3" "369" "40.9" "5.36" "7.14" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01916" "1725" "ENSG00000095059" "DHPS" "A8K688; hsa:1725; M0R1I5; P49366; Q13184; Q13276; Q9UDG0" "" "Hypusine synthesis from eIF5A-lysine" "1" "0" "1.211" "1.345" "1.003" "1.031" "1.152" "1.236" "0.899" "1.194" "0.918" "45.6" "55.3" "61.4" "45.8" "47.0" "52.6" "56.4" "41.0" "54.5" "41.9" "" "" "" "" "" "" "" "" "" "" "27.3" "28.7" "34.0" "21.5" "21.8" "26.9" "26.2" "18.4" "29.6" "41.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2253036871243965201" "False" "High" "IsMasterProtein" "Q15014" "Mortality factor 4-like protein 2 OS=Homo sapiens OX=9606 GN=MORF4L2 PE=1 SV=1" "0.000" "False" "10.688" "14" "4" "4" "4" "288" "32.3" "9.72" "11.34" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "" "Pf05712" "9643" "ENSG00000123562" "MORF4L2" "B3KP92; D3DXA5; hsa:9643; Q15014; Q567V0; Q8J026" "" "HATs acetylate histones" "1" "0" "1.089" "0.982" "1.043" "1.008" "1.087" "1.105" "1.013" "1.065" "0.885" "269.5" "293.6" "264.7" "281.1" "271.6" "292.9" "298.0" "273.1" "286.9" "238.5" "" "" "" "" "" "" "" "" "" "" "161.3" "152.6" "146.6" "131.9" "125.9" "150.0" "138.5" "122.6" "155.7" "238.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1080022240978719765" "False" "High" "IsMasterProtein" "P49721" "Proteasome subunit beta type-2 OS=Homo sapiens OX=9606 GN=PSMB2 PE=1 SV=1" "0.000" "False" "10.684" "12" "3" "20" "3" "201" "22.8" "7.02" "44.41" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00227" "5690" "ENSG00000126067" "PSMB2" "D3DPS0; hsa:5690; P31145; P49721; Q9BWZ9" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Separation of Sister Chromatids; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.965" "0.994" "1.073" "0.998" "1.054" "0.957" "1.157" "0.993" "0.764" "1461.2" "1409.6" "1452.2" "1568.1" "1457.6" "1540.7" "1398.2" "1690.9" "1450.4" "1115.6" "" "" "" "" "" "" "" "" "" "" "874.4" "732.5" "804.2" "736.2" "675.6" "788.7" "650.1" "759.1" "786.9" "1115.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2901873737565675382" "False" "High" "IsMasterProtein" "O95825" "Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=2" "0.000" "False" "10.657" "9" "4" "5" "4" "349" "38.7" "5.78" "15.34" "4" "other metabolic processes" "" "other molecular function" "" "9946" "ENSG00000205758" "CRYZL1" "B2RDX1; B3KQ77; hsa:9946; O95825; Q96DY0; Q9NVY7" "" "" "0" "0" "1.025" "1.022" "1.065" "0.896" "1.103" "1.074" "1.025" "0.998" "0.620" "361.9" "371.1" "370.0" "385.3" "324.2" "399.3" "388.8" "371.0" "361.0" "224.5" "" "" "" "" "" "" "" "" "" "" "216.6" "192.8" "204.9" "180.9" "150.3" "204.4" "180.8" "166.5" "195.9" "224.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3311968132693307525" "False" "High" "IsMasterProtein" "P42773" "Cyclin-dependent kinase 4 inhibitor C OS=Homo sapiens OX=9606 GN=CDKN2C PE=1 SV=1" "0.000" "False" "10.655" "16" "3" "15" "3" "168" "18.1" "6.52" "45.87" "3" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf12796" "1031" "ENSG00000123080" "CDKN2C" "hsa:1031; P42773; Q8TB83" "Cell cycle; Glioblastoma signaling pathways; Vitamin D receptor pathway; G1 to S cell cycle control" "Oxidative Stress Induced Senescence; Oncogene Induced Senescence; Cyclin D associated events in G1; Senescence-Associated Secretory Phenotype (SASP)" "8" "0" "1.046" "1.060" "1.014" "1.093" "1.041" "1.115" "1.209" "1.084" "0.636" "369.0" "386.1" "391.2" "374.1" "403.5" "384.1" "411.5" "446.3" "400.1" "234.7" "" "" "" "" "" "" "" "" "" "" "220.8" "200.7" "216.6" "175.6" "187.0" "196.6" "191.3" "200.3" "217.0" "234.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-60388765585118576" "False" "High" "IsMasterProtein" "Q9H875" "PRKR-interacting protein 1 OS=Homo sapiens OX=9606 GN=PRKRIP1 PE=1 SV=1" "0.000" "False" "10.636" "14" "2" "2" "2" "184" "21.0" "9.79" "9.87" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf06658" "79706" "ENSG00000128563" "PRKRIP1" "B4DGM2; hsa:79706; Q8NDM6; Q96CF8; Q9H875" "" "mRNA Splicing - Major Pathway" "1" "0" "0.938" "0.920" "0.839" "0.880" "0.882" "1.006" "0.984" "0.897" "0.407" "416.8" "390.9" "383.6" "349.9" "366.9" "367.6" "419.2" "410.3" "373.7" "169.7" "" "" "" "" "" "" "" "" "" "" "249.5" "203.1" "212.4" "164.3" "170.1" "188.2" "194.9" "184.2" "202.8" "169.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2644989191906863874" "False" "High" "IsMasterProtein" "Q6ZSZ5" "Rho guanine nucleotide exchange factor 18 OS=Homo sapiens OX=9606 GN=ARHGEF18 PE=1 SV=4" "0.000" "False" "10.625" "3" "3" "4" "3" "1361" "151.5" "6.33" "11.22" "3" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00621, Pf17838" "23370" "ENSG00000104880" "ARHGEF18" "A8MV62; B5ME81; hsa:23370; I3L1I5; O60274; Q6DD92; Q6ZSZ5" "" "G alpha (12/13) signalling events; RHOA GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8619472182958520531" "False" "High" "IsMasterProtein" "P61960" "Ubiquitin-fold modifier 1 OS=Homo sapiens OX=9606 GN=UFM1 PE=1 SV=1" "0.000" "False" "10.617" "60" "3" "11" "3" "85" "9.1" "9.31" "20.40" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "" "Pf03671" "51569" "ENSG00000120686" "UFM1" "hsa:51569; P61960; Q14346; Q5VXS0; Q6IAG6; Q9CPX2; Q9NZF2" "" "" "0" "0" "1.112" "1.184" "1.060" "1.284" "1.162" "1.059" "1.142" "1.119" "0.796" "243.5" "270.8" "288.2" "258.1" "312.7" "283.0" "257.8" "277.9" "272.4" "193.8" "" "" "" "" "" "" "" "" "" "" "145.7" "140.7" "159.6" "121.2" "144.9" "144.9" "119.9" "124.8" "147.8" "193.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "289518910119416826" "False" "High" "IsMasterProtein" "P61966" "AP-1 complex subunit sigma-1A OS=Homo sapiens OX=9606 GN=AP1S1 PE=1 SV=1" "0.000" "False" "10.615" "16" "2" "4" "2" "158" "18.7" "5.73" "8.62" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "1174" "ENSG00000106367" "AP1S1" "B2R5D8; hsa:1174; P61966; P82267; Q00382; Q53YA7; Q9BTN4; Q9UDW9" "" "Lysosome Vesicle Biogenesis; MHC class II antigen presentation; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "4" "0" "1.067" "1.165" "1.120" "1.138" "1.093" "1.149" "1.240" "0.891" "1.462" "76.2" "81.3" "88.7" "85.3" "86.7" "83.2" "87.5" "94.5" "67.9" "111.4" "" "" "" "" "" "" "" "" "" "" "45.6" "42.2" "49.1" "40.1" "40.2" "42.6" "40.7" "42.4" "36.8" "111.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7752798674986433827" "False" "High" "IsMasterProtein" "Q5T4S7" "E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=1" "0.000" "False" "10.611" "1" "5" "5" "5" "5183" "573.5" "6.04" "6.15" "5" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf02207, Pf13764, Pf19423" "23352" "ENSG00000127481" "UBR4" "A8MPT2; A8MQ33; A8MQB1; O60646; O75050; Q4QRK5; Q5T4S7; Q5T4S8; Q5T4S9; Q5TBN8; Q5TBP2; Q6DKH8; Q6P4A4; Q7L8P7; Q8IXJ4; Q8TDN5; Q8WV67; Q9HA46; Q9P2N9; Q9UG82" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation" "2" "0" "1.104" "0.792" "1.265" "1.310" "0.921" "1.342" "0.691" "1.050" "4.581" "34.0" "37.5" "26.9" "43.0" "44.6" "31.3" "45.6" "23.5" "35.7" "155.8" "" "" "" "" "" "" "" "" "" "" "20.4" "19.5" "14.9" "20.2" "20.7" "16.0" "21.2" "10.5" "19.4" "155.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4846658872779087383" "False" "High" "IsMasterProtein" "P61964" "WD repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=WDR5 PE=1 SV=1" "0.000" "False" "10.599" "12" "3" "3" "3" "334" "36.6" "8.27" "10.32" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400" "11091" "ENSG00000196363" "WDR5" "hsa:11091; P61964; Q91VA5; Q9NWX7; Q9UGP9" "Pleural mesothelioma; Kleefstra syndrome" "Neddylation; HATs acetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of WDR5-containing histone-modifying complexes; RMTs methylate histone arginines; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Cardiogenesis" "10" "0" "1.563" "1.497" "1.785" "1.564" "1.445" "1.549" "0.994" "1.632" "1.375" "19.5" "30.5" "29.2" "34.9" "30.6" "28.2" "30.3" "19.4" "31.9" "26.9" "" "" "" "" "" "" "" "" "" "" "11.7" "15.9" "16.2" "16.4" "14.2" "14.4" "14.1" "8.7" "17.3" "26.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1047661720353379507" "False" "High" "IsMasterProtein" "Q03426" "Mevalonate kinase OS=Homo sapiens OX=9606 GN=MVK PE=1 SV=1" "0.000" "False" "10.596" "7" "3" "5" "3" "396" "42.4" "6.46" "9.83" "3" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00288, Pf08544" "4598" "ENSG00000110921" "MVK" "hsa:4598; Q03426" "Cholesterol biosynthesis pathway; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "8" "0" "0.922" "0.800" "1.028" "1.139" "0.943" "1.049" "1.154" "1.064" "0.589" "276.6" "255.0" "221.4" "284.4" "315.0" "260.7" "290.1" "319.3" "294.4" "163.0" "" "" "" "" "" "" "" "" "" "" "165.5" "132.5" "122.6" "133.5" "146.0" "133.5" "134.9" "143.3" "159.7" "163.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7848560432404461068" "False" "High" "IsMasterProtein" "Q16775" "Hydroxyacylglutathione hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HAGH PE=1 SV=2" "0.000" "False" "10.587" "11" "3" "8" "3" "308" "33.8" "8.12" "14.32" "3" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00753, Pf16123" "3029" "ENSG00000063854" "HAGH" "A8K290; B4DP33; B4DRA7; E7EN93; hsa:3029; Q16775" "" "" "0" "0" "1.084" "1.193" "1.095" "1.075" "1.070" "1.129" "1.159" "0.918" "0.806" "144.6" "156.7" "172.5" "158.4" "155.5" "154.8" "163.2" "167.6" "132.8" "116.5" "" "" "" "" "" "" "" "" "" "" "86.5" "81.5" "95.5" "74.4" "72.1" "79.2" "75.9" "75.3" "72.1" "116.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1367534402013747077" "False" "High" "IsMasterProtein" "O75947" "ATP synthase subunit d, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PD PE=1 SV=3" "0.000" "False" "10.534" "11" "2" "4" "2" "161" "18.5" "5.30" "11.96" "2" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05873" "10476" "ENSG00000167863" "ATP5PD" "B2R5L6; hsa:10476; O75947; Q9H3J4" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "5" "0" "0.953" "0.907" "0.927" "0.954" "0.980" "1.002" "1.040" "0.822" "0.306" "352.9" "336.3" "319.9" "327.3" "336.7" "345.9" "353.5" "367.2" "290.0" "108.1" "" "" "" "" "" "" "" "" "" "" "211.2" "174.7" "177.2" "153.7" "156.1" "177.1" "164.4" "164.8" "157.3" "108.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6403678717829717744" "False" "High" "IsMasterProtein" "Q9H3K6" "BolA-like protein 2 OS=Homo sapiens OX=9606 GN=BOLA2B PE=1 SV=1" "0.000" "False" "10.498" "37" "3" "8" "3" "86" "10.1" "6.52" "24.05" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01722" "552900; 654483" "ENSG00000169627; ENSG00000183336" "BOLA2; BOLA2B" "A1L454; A7YDY3; hsa:552900; hsa:654483; Q9H3K6" "" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "1" "0" "1.028" "1.144" "1.027" "1.031" "1.013" "1.074" "0.986" "0.995" "1.191" "339.1" "348.7" "387.8" "348.4" "349.4" "343.4" "364.3" "334.4" "337.4" "403.9" "" "" "" "" "" "" "" "" "" "" "202.9" "181.2" "214.8" "163.5" "162.0" "175.8" "169.4" "150.1" "183.1" "403.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7014036665860809700" "False" "High" "IsMasterProtein" "Q13459" "Unconventional myosin-IXb OS=Homo sapiens OX=9606 GN=MYO9B PE=1 SV=3" "0.000" "False" "10.490" "2" "4" "4" "4" "2157" "243.2" "8.75" "2.80" "4" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf00620, Pf00788" "4650" "ENSG00000099331" "MYO9B" "hsa:4650; O75314; Q13459; Q9NUJ2; Q9UHN0" "Vitamin D receptor pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHOA GTPase cycle; RAC1 GTPase cycle; RHOC GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle; RHOF GTPase cycle; SLIT2:ROBO1 increases RHOA activity" "10" "0" "1.279" "1.013" "1.176" "1.279" "1.299" "1.403" "1.330" "1.261" "2.569" "32.9" "42.0" "33.3" "38.6" "42.0" "42.7" "46.1" "43.7" "41.4" "84.4" "" "" "" "" "" "" "" "" "" "" "19.7" "21.8" "18.4" "18.1" "19.5" "21.8" "21.4" "19.6" "22.5" "84.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5993686438301718268" "False" "High" "IsMasterProtein" "Q96P11" "28S rRNA (cytosine-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NSUN5 PE=1 SV=2" "0.000" "False" "10.488" "10" "4" "5" "4" "429" "46.7" "8.62" "10.56" "4" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf01189, Pf21148, Pf21153" "55695" "ENSG00000130305" "NSUN5" "B3KX04; B4DP79; G3V0G9; hsa:55695; Q6ZUI8; Q96HT9; Q96P11; Q9NW70" "" "" "0" "0" "1.077" "1.086" "0.514" "0.919" "1.478" "1.314" "0.010" "0.855" "8.419" "8.5" "9.2" "9.3" "4.4" "7.9" "12.6" "11.2" "0.0" "7.3" "72.0" "" "" "" "" "" "" "" "" "" "" "5.1" "4.8" "5.1" "2.1" "3.6" "6.5" "5.2" "0.0" "4.0" "72.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "412989267492622894" "False" "High" "IsMasterProtein" "Q12874" "Splicing factor 3A subunit 3 OS=Homo sapiens OX=9606 GN=SF3A3 PE=1 SV=1" "0.000" "False" "10.488" "8" "3" "3" "3" "501" "58.8" "5.38" "10.32" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf11931, Pf12108, Pf13297, Pf16837" "10946" "ENSG00000183431" "SF3A3" "D3DPT5; hsa:10946; Q12874; Q15460; Q5VT87" "Exercise-induced circadian regulation; mRNA processing" "mRNA Splicing - Major Pathway" "3" "0" "1.343" "1.369" "1.135" "1.361" "1.272" "1.496" "0.587" "1.271" "7.924" "117.5" "157.8" "161.0" "133.4" "160.0" "149.5" "175.9" "69.0" "149.4" "931.4" "" "" "" "" "" "" "" "" "" "" "70.3" "82.0" "89.1" "62.6" "74.2" "76.5" "81.8" "31.0" "81.1" "931.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4970453667170528269" "False" "High" "IsMasterProtein" "P16083" "Ribosyldihydronicotinamide dehydrogenase [quinone] OS=Homo sapiens OX=9606 GN=NQO2 PE=1 SV=5" "0.000" "False" "10.487" "9" "2" "4" "2" "231" "25.9" "6.29" "11.15" "2" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf02525" "4835" "ENSG00000124588" "NQO2" "B2R492; P16083; Q5TD04" "Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling" "Phase I - Functionalization of compounds" "2" "0" "1.167" "1.085" "1.132" "1.110" "1.097" "1.152" "1.146" "1.104" "0.566" "269.9" "314.9" "292.8" "305.6" "299.6" "296.0" "310.8" "309.3" "297.9" "152.6" "" "" "" "" "" "" "" "" "" "" "161.5" "163.6" "162.1" "143.5" "138.9" "151.6" "144.5" "138.9" "161.6" "152.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6953685933096655099" "False" "High" "IsMasterProtein" "Q8N465" "D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=D2HGDH PE=1 SV=3" "0.000" "False" "10.458" "7" "4" "5" "4" "521" "56.4" "7.99" "12.99" "4" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf01565, Pf02913" "728294" "ENSG00000180902" "D2HGDH" "B4E3L6; E7ENP2; hsa:728294; Q6IQ24; Q8N465; Q8N5Q8" "2q37 copy number variation syndrome" "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" "2" "0" "1.136" "0.998" "1.399" "0.982" "0.863" "1.120" "1.133" "1.036" "0.781" "122.6" "139.2" "122.3" "171.4" "120.4" "105.8" "137.2" "138.8" "126.9" "95.7" "" "" "" "" "" "" "" "" "" "" "73.3" "72.3" "67.7" "80.5" "55.8" "54.2" "63.8" "62.3" "68.9" "95.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "400708693502021351" "False" "High" "IsMasterProtein" "Q12857" "Nuclear factor 1 A-type OS=Homo sapiens OX=9606 GN=NFIA PE=1 SV=2" "0.000" "False" "10.453" "6" "2" "2" "2" "509" "55.9" "8.44" "7.22" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00859, Pf03165, Pf10524" "4774" "ENSG00000162599" "NFIA" "B4DRJ3; B4DS53; F5H0R0; F8W8W3; hsa:4774; Q12857; Q8TA97; Q9H3X9; Q9P2A9" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3427598645898203721" "False" "High" "IsMasterProtein" "O14828" "Secretory carrier-associated membrane protein 3 OS=Homo sapiens OX=9606 GN=SCAMP3 PE=1 SV=3" "0.000" "False" "10.432" "15" "3" "3" "3" "347" "38.3" "7.64" "8.84" "3" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04144" "10067" "ENSG00000116521; ENSG00000263290" "SCAMP3" "A9Z1W6; B1AVS6; hsa:10067; O14828; O15128; Q96FR8; Q9BPY0" "" "" "0" "0" "0.893" "0.975" "0.996" "1.123" "1.027" "0.981" "1.035" "1.053" "0.899" "208.1" "185.7" "202.9" "207.2" "233.7" "213.7" "204.0" "215.4" "219.2" "187.1" "" "" "" "" "" "" "" "" "" "" "124.5" "96.5" "112.4" "97.3" "108.3" "109.4" "94.9" "96.7" "118.9" "187.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7794810011178551467" "False" "High" "IsMasterProtein" "O75348" "V-type proton ATPase subunit G 1 OS=Homo sapiens OX=9606 GN=ATP6V1G1 PE=1 SV=3" "0.000" "False" "10.428" "17" "2" "3" "2" "118" "13.7" "8.79" "11.09" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf03179" "9550" "ENSG00000136888" "ATP6V1G1" "hsa:9550; O75348; Q6IB33" "Osteoclast signaling; Proximal tubule transport" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "7" "0" "0.918" "0.950" "0.821" "0.939" "0.926" "0.960" "1.015" "0.874" "0.564" "406.2" "373.0" "385.8" "333.6" "381.5" "376.3" "390.0" "412.2" "355.0" "229.3" "" "" "" "" "" "" "" "" "" "" "243.1" "193.8" "213.7" "156.6" "176.8" "192.6" "181.4" "185.1" "192.6" "229.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8090563644210438212" "False" "High" "IsMasterProtein" "Q6V1X1" "Dipeptidyl peptidase 8 OS=Homo sapiens OX=9606 GN=DPP8 PE=1 SV=1" "0.000" "False" "10.426" "3" "3" "6" "3" "898" "103.3" "5.80" "15.38" "3" "protein metabolism;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00326, Pf00930, Pf19520" "54878" "ENSG00000074603" "DPP8" "hsa:54878; Q6V1X1; Q7Z4C8; Q7Z4D3; Q7Z4E1; Q8IWG7; Q8NEM5; Q96JX1; Q9HBM2; Q9HBM3; Q9HBM4; Q9HBM5; Q9NXF4" "" "" "0" "0" "1.015" "0.873" "1.054" "1.023" "0.978" "0.969" "1.041" "0.977" "0.761" "253.5" "257.2" "221.2" "267.2" "259.3" "247.9" "245.6" "264.0" "247.6" "192.9" "" "" "" "" "" "" "" "" "" "" "151.7" "133.7" "122.5" "125.4" "120.2" "126.9" "114.2" "118.5" "134.3" "192.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3758284595644048114" "False" "High" "IsMasterProtein" "P78345" "Ribonuclease P protein subunit p38 OS=Homo sapiens OX=9606 GN=RPP38 PE=1 SV=2" "0.000" "False" "10.418" "13" "3" "3" "3" "283" "31.8" "9.92" "9.59" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01248" "10557" "ENSG00000152464" "RPP38" "B3KPY0; D3DRT8; hsa:10557; P78345; Q53F71; Q8NHS8" "Sphingolipid metabolism in senescence" "Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus" "3" "0" "1.068" "0.939" "1.151" "1.183" "1.090" "1.058" "0.911" "0.973" "1.094" "117.0" "125.0" "109.9" "134.7" "138.5" "127.6" "123.8" "106.6" "113.8" "128.0" "" "" "" "" "" "" "" "" "" "" "70.0" "64.9" "60.8" "63.2" "64.2" "65.3" "57.6" "47.9" "61.8" "128.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8148433569690540229" "False" "High" "IsMasterProtein" "Q96C36" "Pyrroline-5-carboxylate reductase 2 OS=Homo sapiens OX=9606 GN=PYCR2 PE=1 SV=1" "0.000" "False" "10.412" "9" "3" "10" "2" "320" "33.6" "7.77" "20.02" "3" "other metabolic processes;stress response" "mitochondrion" "other molecular function" "Pf03807, Pf14748" "29920" "ENSG00000143811" "PYCR2" "A8K798; hsa:29920; Q7Z515; Q96C36; Q9Y5J4" "Metabolic reprogramming in colon cancer" "Glutamate and glutamine metabolism" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2254798804738061271" "False" "High" "IsMasterProtein" "O60271" "C-Jun-amino-terminal kinase-interacting protein 4 OS=Homo sapiens OX=9606 GN=SPAG9 PE=1 SV=4" "0.000" "False" "10.384" "3" "3" "3" "3" "1321" "146.1" "5.15" "8.16" "3" "transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf09744, Pf16471, Pf19056" "9043" "ENSG00000008294" "SPAG9" "A6H8U5; A8MSX0; B4DHH2; hsa:9043; O60271; O60905; Q3KQU8; Q3MKM7; Q86WC7; Q86WC8; Q8IZX7; Q96II0; Q9H811" "" "Myogenesis" "1" "0" "0.994" "1.368" "1.347" "1.082" "1.100" "1.294" "1.037" "1.290" "3.491" "80.1" "79.6" "109.6" "107.9" "86.7" "88.1" "103.6" "83.1" "103.3" "279.6" "" "" "" "" "" "" "" "" "" "" "47.9" "41.3" "60.7" "50.6" "40.2" "45.1" "48.2" "37.3" "56.0" "279.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8454366493935613494" "False" "High" "IsMasterProtein" "P19404" "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV2 PE=1 SV=2" "0.000" "False" "10.371" "8" "2" "13" "2" "249" "27.4" "8.06" "34.32" "2" "other metabolic processes;transport;developmental processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf01257" "4729" "ENSG00000178127" "NDUFV2" "hsa:4729; P19404; Q9BV41" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "0.854" "0.966" "0.988" "1.039" "0.811" "1.143" "0.963" "0.880" "0.891" "170.1" "145.2" "164.3" "168.0" "176.8" "138.0" "194.5" "163.9" "149.7" "151.5" "" "" "" "" "" "" "" "" "" "" "101.8" "75.5" "91.0" "78.9" "81.9" "70.7" "90.4" "73.6" "81.2" "151.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7598274604461767952" "False" "High" "IsMasterProtein" "P49750" "YLP motif-containing protein 1 OS=Homo sapiens OX=9606 GN=YLPM1 PE=1 SV=4" "0.000" "False" "10.365" "2" "4" "5" "4" "2146" "241.5" "6.55" "4.91" "4" "other biological processes" "nucleus" "" "Pf13671" "56252" "ENSG00000119596" "YLPM1" "hsa:56252; P49750; P49752; Q96I64; Q9P1V7" "" "" "0" "0" "1.151" "1.051" "1.033" "1.327" "1.168" "1.059" "1.193" "0.926" "0.888" "42.0" "48.3" "44.2" "43.4" "55.8" "49.1" "44.5" "50.1" "38.9" "37.3" "" "" "" "" "" "" "" "" "" "" "25.1" "25.1" "24.5" "20.4" "25.8" "25.1" "20.7" "22.5" "21.1" "37.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "499510966834701259" "False" "High" "IsMasterProtein" "Q96GS4" "BLOC-1-related complex subunit 6 OS=Homo sapiens OX=9606 GN=BORCS6 PE=1 SV=2" "0.000" "False" "10.348" "10" "2" "2" "2" "357" "37.2" "5.76" "7.08" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf10157" "54785" "ENSG00000196544" "BORCS6" "hsa:54785; Q53HS4; Q96GS4; Q9NXW8" "" "" "0" "0" "0.577" "1.314" "1.387" "1.124" "0.839" "1.098" "1.120" "1.135" "0.911" "24.7" "14.3" "32.4" "34.2" "27.7" "20.7" "27.1" "27.7" "28.0" "22.5" "" "" "" "" "" "" "" "" "" "" "14.8" "7.4" "18.0" "16.1" "12.9" "10.6" "12.6" "12.4" "15.2" "22.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5142432278754861003" "False" "High" "IsMasterProtein" "Q5TEC6" "Histone H3-7 OS=Homo sapiens OX=9606 GN=H3-7 PE=1 SV=1" "0.000" "False" "10.331" "26" "4" "15" "2" "136" "15.4" "11.27" "47.05" "4" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "" "ENSG00000273213" "H3-7" "Q5TEC6" "" "" "0" "0" "0.747" "0.950" "0.794" "0.766" "0.870" "0.576" "0.726" "0.761" "1.068" "431.1" "322.1" "409.8" "342.1" "330.2" "375.1" "248.1" "312.8" "328.1" "460.6" "" "" "" "" "" "" "" "" "" "" "258.0" "167.4" "226.9" "160.6" "153.1" "192.0" "115.4" "140.4" "178.0" "460.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8124726233717471609" "False" "High" "IsMasterProtein" "P50750" "Cyclin-dependent kinase 9 OS=Homo sapiens OX=9606 GN=CDK9 PE=1 SV=3" "0.000" "False" "10.330" "11" "4" "9" "3" "372" "42.8" "8.79" "21.66" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "1025" "ENSG00000136807" "CDK9" "hsa:1025; P50750; Q5JU24; Q5JU25; Q5U006; Q96TF1" "MicroRNAs in cardiomyocyte hypertrophy; IL-9 signaling pathway; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins" "20" "0" "0.842" "0.864" "0.960" "0.944" "0.975" "1.083" "0.893" "0.879" "1.351" "165.0" "139.0" "142.6" "158.4" "155.7" "160.9" "178.8" "147.3" "145.0" "223.0" "" "" "" "" "" "" "" "" "" "" "98.7" "72.2" "78.9" "74.4" "72.2" "82.4" "83.1" "66.1" "78.7" "223.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3668121595413898342" "False" "High" "IsMasterProtein" "Q96D46" "60S ribosomal export protein NMD3 OS=Homo sapiens OX=9606 GN=NMD3 PE=1 SV=1" "0.000" "False" "10.314" "7" "3" "3" "3" "503" "57.6" "7.14" "7.06" "3" "transport;other biological processes" "nucleus;other cell component" "translation activity;other molecular function" "Pf04981, Pf21192, Pf21193" "51068" "ENSG00000169251" "NMD3" "D3DNM7; hsa:51068; Q96D46; Q9Y2Z6" "" "" "0" "0" "1.147" "0.937" "1.226" "1.096" "1.295" "1.274" "1.251" "0.944" "1.462" "88.9" "102.0" "83.4" "109.1" "97.5" "115.2" "113.3" "111.3" "83.9" "130.0" "" "" "" "" "" "" "" "" "" "" "53.2" "53.0" "46.2" "51.2" "45.2" "59.0" "52.7" "50.0" "45.5" "130.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1124967282390941354" "False" "High" "IsMasterProtein" "Q9HB90" "Ras-related GTP-binding protein C OS=Homo sapiens OX=9606 GN=RRAGC PE=1 SV=1" "0.000" "False" "10.311" "7" "3" "4" "3" "399" "44.2" "5.10" "10.28" "3" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04670" "64121" "ENSG00000116954" "RRAGC" "hsa:64121; Q9H202; Q9H8Q8; Q9HB90" "Target of rapamycin signaling; Orexin receptor pathway; 2q37 copy number variation syndrome" "TP53 Regulates Metabolic Genes; Regulation of PTEN gene transcription; Macroautophagy; Amino acids regulate mTORC1; mTORC1-mediated signalling; Energy dependent regulation of mTOR by LKB1-AMPK" "10" "0" "1.273" "0.919" "0.984" "0.946" "1.067" "0.741" "1.157" "1.056" "0.618" "109.8" "139.7" "100.9" "108.0" "103.8" "117.2" "81.4" "127.1" "115.9" "67.9" "" "" "" "" "" "" "" "" "" "" "65.7" "72.6" "55.9" "50.7" "48.1" "60.0" "37.8" "57.0" "62.9" "67.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2243304084648640018" "False" "High" "IsMasterProtein" "P49585" "Choline-phosphate cytidylyltransferase A OS=Homo sapiens OX=9606 GN=PCYT1A PE=1 SV=2" "0.000" "False" "10.296" "10" "4" "5" "4" "367" "41.7" "7.25" "11.59" "4" "other metabolic processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01467" "5130" "ENSG00000161217" "PCYT1A" "A9LYK9; D3DXB1; hsa:5130; P49585; Q86Y88" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids; 3q29 copy number variation syndrome; Acetylcholine synthesis" "Synthesis of PC" "7" "0" "1.192" "1.268" "1.174" "1.119" "0.949" "1.124" "0.875" "1.368" "2.492" "45.3" "54.0" "57.4" "53.2" "50.7" "43.0" "50.9" "39.6" "61.9" "112.8" "" "" "" "" "" "" "" "" "" "" "27.1" "28.0" "31.8" "25.0" "23.5" "22.0" "23.7" "17.8" "33.6" "112.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9119616111706856744" "False" "High" "IsMasterProtein" "Q9ULZ3" "Apoptosis-associated speck-like protein containing a CARD OS=Homo sapiens OX=9606 GN=PYCARD PE=1 SV=2" "0.000" "False" "10.294" "19" "4" "6" "4" "195" "21.6" "6.34" "12.80" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00619, Pf02758" "29108" "ENSG00000103490" "PYCARD" "hsa:29108; Q96D12; Q9BSZ5; Q9HBD0; Q9NXJ8; Q9ULZ3" "Nucleotide-binding oligomerization domain (NOD) pathway; Nanomaterial-induced inflammasome activation; TYROBP causal network in microglia; Acute viral myocarditis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Prostaglandin signaling" "Neutrophil degranulation; The AIM2 inflammasome; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; CLEC7A/inflammasome pathway" "13" "0" "0.933" "1.021" "0.863" "0.995" "0.920" "1.087" "1.330" "1.328" "0.785" "54.1" "50.5" "55.3" "46.7" "53.9" "49.8" "58.8" "72.0" "71.9" "42.5" "" "" "" "" "" "" "" "" "" "" "32.4" "26.3" "30.6" "21.9" "25.0" "25.5" "27.4" "32.3" "39.0" "42.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3208052669097016746" "False" "High" "IsMasterProtein" "P51608" "Methyl-CpG-binding protein 2 OS=Homo sapiens OX=9606 GN=MECP2 PE=1 SV=1" "0.000" "False" "10.289" "5" "2" "2" "2" "486" "52.4" "9.95" "8.53" "2" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429" "4204" "ENSG00000169057" "MECP2" "hsa:4204; O15233; P51608; Q6QHH9; Q7Z384" "Ectoderm differentiation; MECP2 and associated Rett syndrome; Lung fibrosis; Rett syndrome; Transcription co-factors SKI and SKIL protein partners; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Neurogenesis regulation in the olfactory epithelium; ADHD and autism (ASD) linked metabolic pathways and SNP; Sudden infant death syndrome (SIDS) susceptibility pathways" "" "10" "0" "0.977" "0.780" "0.800" "1.150" "0.921" "0.941" "1.152" "0.884" "0.649" "110.4" "107.8" "86.1" "88.3" "126.9" "101.7" "103.9" "127.2" "97.5" "71.7" "" "" "" "" "" "" "" "" "" "" "66.1" "56.0" "47.7" "41.5" "58.8" "52.1" "48.3" "57.1" "52.9" "71.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5155444033397587021" "False" "High" "IsMasterProtein" "Q06265" "Exosome complex component RRP45 OS=Homo sapiens OX=9606 GN=EXOSC9 PE=1 SV=3" "0.000" "False" "10.288" "7" "3" "6" "3" "439" "48.9" "5.29" "15.30" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "5393" "ENSG00000123737" "EXOSC9" "hsa:5393; Q06265; Q12883; Q4W5P5; Q86Y41; Q86Y48" "Ciliary landscape" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "7" "0" "1.017" "0.903" "0.929" "0.873" "0.863" "0.940" "0.986" "0.905" "0.469" "284.4" "289.3" "256.8" "264.2" "248.4" "245.5" "267.3" "280.3" "257.5" "133.4" "" "" "" "" "" "" "" "" "" "" "170.2" "150.3" "142.2" "124.1" "115.1" "125.7" "124.3" "125.8" "139.7" "133.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-100353375695918439" "False" "High" "IsMasterProtein" "P53999" "Activated RNA polymerase II transcriptional coactivator p15 OS=Homo sapiens OX=9606 GN=SUB1 PE=1 SV=3" "0.000" "False" "10.288" "16" "2" "5" "2" "127" "14.4" "9.60" "14.63" "2" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02229" "10923" "ENSG00000113387" "SUB1" "hsa:10923; P53999; Q96L29" "" "" "0" "0" "0.910" "0.853" "0.855" "0.989" "0.989" "0.937" "0.945" "0.867" "0.511" "343.5" "312.7" "292.9" "293.6" "339.5" "339.6" "322.0" "324.5" "298.0" "175.7" "" "" "" "" "" "" "" "" "" "" "205.5" "162.5" "162.2" "137.8" "157.4" "173.9" "149.7" "145.7" "161.7" "175.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2413702222549115072" "False" "High" "IsMasterProtein" "P13693" "Translationally-controlled tumor protein OS=Homo sapiens OX=9606 GN=TPT1 PE=1 SV=1" "0.000" "False" "10.277" "17" "3" "10" "3" "172" "19.6" "4.93" "28.94" "3" "transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00838" "7178" "ENSG00000133112" "TPT1" "B2R7E5; hsa:7178; P13693; Q6YLS2; Q7Z4J4; Q8TBK7; Q96EE2; Q9UC70" "" "" "0" "0" "1.067" "1.113" "1.021" "1.021" "1.084" "1.055" "1.068" "1.031" "1.418" "1218.8" "1301.0" "1356.0" "1243.9" "1244.6" "1321.1" "1285.5" "1301.4" "1257.1" "1727.8" "" "" "" "" "" "" "" "" "" "" "729.4" "676.1" "750.9" "584.0" "576.9" "676.3" "597.7" "584.3" "682.0" "1727.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3076278996676727483" "False" "High" "IsMasterProtein" "P53350" "Serine/threonine-protein kinase PLK1 OS=Homo sapiens OX=9606 GN=PLK1 PE=1 SV=1" "0.000" "False" "10.273" "8" "5" "5" "5" "603" "68.2" "8.91" "8.88" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00659" "5347" "ENSG00000166851" "PLK1" "hsa:5347; P53350; Q15153; Q99746" "Cell cycle; Integrated cancer pathway; Androgen receptor network in prostate cancer; TNF-alpha signaling pathway; 22q11.2 copy number variation syndrome; Cohesin complex - Cornelia de Lange syndrome" "The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; Phosphorylation of the APC/C; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; Polo-like kinase mediated events; Activation of NIMA Kinases NEK9, NEK6, NEK7; Phosphorylation of Emi1; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Mitotic Telophase/Cytokinesis; Mitotic Metaphase/Anaphase Transition" "30" "0" "1.347" "1.197" "1.159" "1.081" "1.107" "1.063" "1.134" "1.302" "1.053" "46.7" "62.9" "55.9" "54.1" "50.5" "51.7" "49.7" "53.0" "60.8" "49.2" "" "" "" "" "" "" "" "" "" "" "27.9" "32.7" "31.0" "25.4" "23.4" "26.5" "23.1" "23.8" "33.0" "49.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-313217822058437387" "False" "High" "IsMasterProtein" "P55789" "FAD-linked sulfhydryl oxidase ALR OS=Homo sapiens OX=9606 GN=GFER PE=1 SV=2" "0.000" "False" "10.265" "18" "2" "2" "2" "205" "23.4" "7.62" "8.83" "2" "developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;mitochondrion" "signal transduction activity or receptor binding;other molecular function" "Pf04777" "2671" "ENSG00000127554; ENSG00000291944" "GFER" "hsa:2671; P55789; Q53YM6; Q8TAH6; Q9H290; Q9UK40" "" "Mitochondrial protein import" "1" "0" "0.951" "0.967" "0.630" "0.934" "0.525" "0.748" "0.950" "0.767" "0.481" "26.9" "25.6" "26.0" "17.0" "25.1" "14.1" "20.1" "25.6" "20.7" "12.9" "" "" "" "" "" "" "" "" "" "" "16.1" "13.3" "14.4" "8.0" "11.7" "7.2" "9.4" "11.5" "11.2" "12.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8840476301148053294" "False" "High" "IsMasterProtein" "Q9NVI1" "Fanconi anemia group I protein OS=Homo sapiens OX=9606 GN=FANCI PE=1 SV=4" "0.000" "False" "10.262" "4" "4" "4" "4" "1328" "149.2" "6.74" "6.86" "4" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf14674, Pf14675, Pf14676, Pf14677, Pf14678, Pf14679, Pf14680" "55215" "ENSG00000140525" "FANCI" "A4ZVE4; A5YMH4; A6NJZ0; hsa:55215; Q96JN1; Q96ST0; Q9BT96; Q9NVI1" "Gastric cancer network 2; DNA repair pathways, full network; 15q11q13 copy number variation" "TP53 Regulates Transcription of DNA Repair Genes; Fanconi Anemia Pathway" "5" "0" "1.320" "1.564" "1.067" "1.315" "1.313" "1.038" "1.238" "1.320" "4.274" "17.0" "22.5" "26.7" "18.2" "22.4" "22.4" "17.7" "21.1" "22.5" "72.9" "" "" "" "" "" "" "" "" "" "" "10.2" "11.7" "14.8" "8.5" "10.4" "11.5" "8.2" "9.5" "12.2" "72.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4889317708786741676" "False" "High" "IsMasterProtein" "Q96AT1" "Uncharacterized protein KIAA1143 OS=Homo sapiens OX=9606 GN=KIAA1143 PE=1 SV=2" "0.000" "False" "10.252" "20" "3" "7" "3" "154" "17.5" "6.11" "22.21" "3" "" "" "" "Pf15377" "57456" "ENSG00000163807; ENSG00000281665" "KIAA1143" "A8K0I4; hsa:57456; Q96AT1; Q96HJ8; Q9ULS7" "" "" "0" "0" "0.837" "0.861" "0.787" "0.919" "0.844" "0.899" "0.941" "0.806" "0.372" "874.5" "732.2" "752.9" "688.0" "803.7" "738.4" "785.8" "822.8" "705.3" "325.5" "" "" "" "" "" "" "" "" "" "" "523.3" "380.5" "416.9" "323.0" "372.5" "378.0" "365.4" "369.4" "382.6" "325.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4424001123554839232" "False" "High" "IsMasterProtein" "Q96CW1" "AP-2 complex subunit mu OS=Homo sapiens OX=9606 GN=AP2M1 PE=1 SV=2" "0.000" "False" "10.239" "7" "4" "7" "4" "435" "49.6" "9.54" "13.94" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00928, Pf01217" "1173" "ENSG00000161203" "AP2M1" "A6NE12; D3DNT1; hsa:1173; P20172; P53679; Q96CW1" "Synaptic vesicle pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; GDNF signaling" "Cargo recognition for clathrin-mediated endocytosis; MHC class II antigen presentation; Potential therapeutics for SARS; Recycling pathway of L1; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Nef mediated downregulation of CD28 cell surface expression; Formation of annular gap junctions" "21" "0" "1.107" "1.080" "1.220" "1.232" "1.256" "1.142" "1.129" "1.127" "1.525" "243.4" "269.4" "263.0" "296.8" "299.9" "305.6" "278.0" "274.8" "274.2" "371.2" "" "" "" "" "" "" "" "" "" "" "145.6" "140.0" "145.6" "139.3" "139.0" "156.5" "129.3" "123.4" "148.8" "371.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3984777124948273039" "False" "High" "IsMasterProtein" "O94903" "Pyridoxal phosphate homeostasis protein OS=Homo sapiens OX=9606 GN=PLPBP PE=1 SV=1" "0.000" "False" "10.227" "12" "4" "8" "4" "275" "30.3" "7.50" "15.24" "4" "" "cytosol;other cell component" "other molecular function" "Pf01168" "11212" "ENSG00000147471" "PLPBP" "O94903; Q6FI94" "" "" "0" "0" "0.865" "0.922" "0.973" "1.102" "0.992" "0.903" "0.893" "0.979" "2.011" "322.0" "278.6" "296.8" "313.1" "354.8" "319.3" "290.9" "287.7" "315.2" "647.5" "" "" "" "" "" "" "" "" "" "" "192.7" "144.8" "164.4" "147.0" "164.5" "163.5" "135.3" "129.2" "171.0" "647.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-140378452823337742" "False" "High" "IsMasterProtein" "Q9HCN4" "GPN-loop GTPase 1 OS=Homo sapiens OX=9606 GN=GPN1 PE=1 SV=1" "0.000" "False" "10.199" "10" "3" "3" "3" "374" "41.7" "4.92" "7.59" "3" "" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf03029" "11321" "ENSG00000198522" "GPN1" "B4DQJ5; B4DQM4; B4DXU4; B5MBZ5; hsa:11321; O76004; Q9HCN4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4372358057775812967" "False" "High" "IsMasterProtein" "Q9UMZ2" "Synergin gamma OS=Homo sapiens OX=9606 GN=SYNRG PE=1 SV=2" "0.000" "False" "10.169" "2" "3" "3" "3" "1314" "140.6" "5.03" "8.15" "3" "transport" "other membranes;ER/Golgi;other cell component" "" "" "11276" "ENSG00000274047; ENSG00000275066" "SYNRG" "A8MWU4; B7ZKZ2; B7ZKZ3; hsa:11276; Q17RI2; Q5BKU5; Q6ZT17; Q9UMZ2" "17q12 copy number variation syndrome" "" "1" "0" "1.101" "1.124" "1.197" "1.226" "1.061" "1.156" "1.115" "1.146" "1.264" "326.1" "358.9" "366.6" "390.4" "399.7" "345.9" "377.0" "363.6" "373.7" "412.2" "" "" "" "" "" "" "" "" "" "" "195.2" "186.5" "203.0" "183.3" "185.3" "177.1" "175.3" "163.2" "202.7" "412.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3761626498643372027" "False" "High" "IsMasterProtein" "P05362" "Intercellular adhesion molecule 1 OS=Homo sapiens OX=9606 GN=ICAM1 PE=1 SV=2" "0.000" "False" "10.168" "4" "2" "2" "2" "532" "57.8" "7.99" "6.85" "2" "cell adhesion;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "signal transduction activity or receptor binding;other molecular function" "Pf03921, Pf13895, Pf21146" "3383" "ENSG00000090339" "ICAM1" "B2R6M3; hsa:3383; P05362; Q5NKV7; Q96B50" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; Interleukin-11 signaling pathway; Spinal cord injury; Complement system; IL1 and megakaryocytes in obesity; Photodynamic therapy-induced NF-kB survival signaling; VEGFA-VEGFR2 signaling; miRNA role in immune response in sepsis; Platelet-mediated interactions with vascular and circulating cells; Cells and molecules involved in local acute inflammatory response ; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; CAMKK2 pathway; p53 transcriptional gene network; Orexin receptor pathway; Urotensin-II-mediated signaling pathway; Role of ROS in COVID-19 endothelial dysfunction; IL-26 signaling pathways; Type II interferon signaling" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; Interleukin-10 signaling; Interleukin-4 and Interleukin-13 signaling; Interferon gamma signaling" "27" "0" "0.874" "0.649" "0.880" "0.778" "0.704" "1.161" "0.817" "0.901" "0.253" "54.1" "47.3" "35.1" "47.6" "42.1" "38.1" "62.8" "44.2" "48.7" "13.7" "" "" "" "" "" "" "" "" "" "" "32.4" "24.6" "19.4" "22.3" "19.5" "19.5" "29.2" "19.8" "26.4" "13.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7211345083341158849" "False" "High" "IsMasterProtein" "Q15382" "GTP-binding protein Rheb OS=Homo sapiens OX=9606 GN=RHEB PE=1 SV=1" "0.000" "False" "10.148" "13" "3" "8" "3" "184" "20.5" "5.92" "21.28" "3" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00071" "6009" "ENSG00000106615" "RHEB" "B3KWN6; D3DX13; hsa:6009; Q15382; Q53Y56; Q99444" "Target of rapamycin signaling; Follicle stimulating hormone (FSH) signaling pathway; Polycystic kidney disease pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Joubert syndrome; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway" "mTORC1-mediated signalling; Macroautophagy; Regulation of PTEN gene transcription; Amino acids regulate mTORC1; TP53 Regulates Metabolic Genes; Energy dependent regulation of mTOR by LKB1-AMPK" "26" "0" "0.902" "0.926" "0.912" "0.892" "1.071" "0.918" "1.021" "0.958" "0.749" "484.6" "437.0" "448.6" "441.8" "432.3" "518.9" "445.1" "494.7" "464.5" "362.8" "" "" "" "" "" "" "" "" "" "" "290.0" "227.1" "248.4" "207.4" "200.4" "265.7" "206.9" "222.1" "252.0" "362.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5987314834012537405" "False" "High" "IsMasterProtein" "O60888" "Protein CutA OS=Homo sapiens OX=9606 GN=CUTA PE=1 SV=2" "0.000" "False" "10.142" "8" "1" "10" "1" "179" "19.1" "5.50" "28.18" "1" "other biological processes" "other membranes" "other molecular function" "Pf03091" "51596" "ENSG00000112514; ENSG00000226492" "CUTA" "A2AB26; A2BEL4; hsa:51596; O60888; Q3B784; Q5JXM9; Q5SU05; Q9NYQ9" "" "" "0" "0" "0.890" "0.871" "1.122" "1.001" "0.975" "1.116" "0.975" "1.030" "0.543" "241.2" "214.8" "210.0" "270.6" "241.5" "235.3" "269.1" "235.3" "248.4" "130.9" "" "" "" "" "" "" "" "" "" "" "144.4" "111.6" "116.3" "127.0" "112.0" "120.4" "125.1" "105.6" "134.8" "130.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6974141516308557016" "False" "High" "IsMasterProtein" "Q969T9" "WW domain-binding protein 2 OS=Homo sapiens OX=9606 GN=WBP2 PE=1 SV=1" "0.000" "False" "10.137" "13" "3" "4" "3" "261" "28.1" "5.91" "11.42" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02893" "23558" "ENSG00000132471" "WBP2" "B4DFG2; O95638; Q969T9" "" "" "0" "0" "0.949" "0.996" "0.952" "0.930" "0.976" "0.926" "0.908" "1.030" "1.090" "319.9" "303.7" "318.7" "304.6" "297.3" "312.2" "296.1" "290.5" "329.5" "348.6" "" "" "" "" "" "" "" "" "" "" "191.4" "157.8" "176.5" "143.0" "137.8" "159.8" "137.7" "130.4" "178.8" "348.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1612491288449717862" "False" "High" "IsMasterProtein" "Q13155" "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 OS=Homo sapiens OX=9606 GN=AIMP2 PE=1 SV=2" "0.000" "False" "10.125" "10" "3" "4" "3" "320" "35.3" "8.22" "13.09" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00043, Pf16780, Pf18569" "7965" "ENSG00000106305" "AIMP2" "F8W950; hsa:7965; Q13155; Q75MR1; Q96CZ5; Q9P1L2" "Osteoclast signaling; Transcriptional activation by NRF2 in response to phytochemicals; NRF2-ARE regulation" "Cytosolic tRNA aminoacylation; Selenoamino acid metabolism" "5" "0" "1.085" "1.126" "1.584" "1.023" "1.211" "0.995" "0.511" "2.004" "6.943" "184.6" "200.3" "207.9" "292.4" "188.9" "223.5" "183.7" "94.4" "369.9" "1281.6" "" "" "" "" "" "" "" "" "" "" "110.5" "104.1" "115.1" "137.3" "87.5" "114.4" "85.4" "42.4" "200.7" "1281.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8434101151437963191" "False" "High" "IsMasterProtein" "Q7Z2K8" "G protein-regulated inducer of neurite outgrowth 1 OS=Homo sapiens OX=9606 GN=GPRIN1 PE=1 SV=2" "0.000" "False" "10.108" "4" "4" "5" "4" "1008" "102.3" "8.06" "11.67" "4" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf15235" "114787" "ENSG00000169258" "GPRIN1" "C9JM70; hsa:114787; Q7Z2K8; Q8ND74; Q96PZ4" "MECP2 and associated Rett syndrome; 5q35 copy number variation" "MECP2 regulates neuronal receptors and channels" "3" "0" "0.954" "0.957" "1.089" "1.395" "1.300" "1.254" "1.232" "1.211" "0.728" "85.9" "82.0" "82.2" "93.6" "119.9" "111.7" "107.8" "105.9" "104.1" "62.6" "" "" "" "" "" "" "" "" "" "" "51.4" "42.6" "45.5" "43.9" "55.6" "57.2" "50.1" "47.5" "56.5" "62.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1297378894876740813" "False" "High" "IsMasterProtein" "Q16854" "Deoxyguanosine kinase, mitochondrial OS=Homo sapiens OX=9606 GN=DGUOK PE=1 SV=2" "0.000" "False" "10.104" "12" "3" "5" "3" "277" "32.0" "8.66" "12.80" "3" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf01712" "1716" "ENSG00000114956" "DGUOK" "hsa:1716; P78532; Q16759; Q16854; Q4ZG09; Q7L1W9; Q96BC1" "Genetic causes of porto-sinusoidal vascular disease" "Purine salvage" "2" "0" "1.031" "0.980" "0.974" "1.026" "1.060" "0.945" "1.041" "1.044" "0.616" "519.8" "535.6" "509.5" "506.3" "533.1" "551.1" "491.0" "541.2" "542.6" "320.0" "" "" "" "" "" "" "" "" "" "" "311.0" "278.3" "282.2" "237.7" "247.1" "282.1" "228.3" "243.0" "294.4" "320.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3933155493213774730" "False" "High" "IsMasterProtein" "Cont_Q3SZV7" "Hemopexin OS=Bos taurus OX=9913 GN=HPX PE=2 SV=1" "0.000" "True" "10.095" "7" "4" "6" "4" "459" "52.2" "7.80" "11.08" "4" "other metabolic processes;transport;other biological processes" "non-structural extracellular" "transporter activity;other molecular function" "Pf00045" "534509" "ENSBIXG00000017851" "HPX" "A0A4W2EKG5; bta:534509; Q3SZV7" "" "" "0" "0" "1.157" "1.084" "1.105" "0.806" "0.951" "1.197" "1.015" "1.151" "0.698" "444.8" "514.5" "482.2" "491.4" "358.7" "423.0" "532.5" "451.6" "512.1" "310.5" "" "" "" "" "" "" "" "" "" "" "266.2" "267.4" "267.0" "230.7" "166.3" "216.5" "247.6" "202.7" "277.9" "310.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7953357218888963531" "False" "High" "IsMasterProtein" "Q3KQU3" "MAP7 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MAP7D1 PE=1 SV=1" "0.000" "False" "10.081" "5" "4" "4" "4" "841" "92.8" "10.11" "8.62" "4" "cell organization and biogenesis" "cytoskeleton;other cell component" "" "Pf05672" "55700" "ENSG00000116871" "MAP7D1" "D3DPS4; hsa:55700; Q3KQU3; Q7L8J5; Q8N905; Q8TAK0; Q9HBQ2; Q9NW29; Q9ULN3" "" "" "0" "0" "1.212" "0.897" "1.158" "1.211" "0.995" "1.200" "1.332" "1.132" "1.898" "83.5" "101.3" "75.0" "96.7" "101.2" "83.2" "100.2" "111.3" "94.6" "158.6" "" "" "" "" "" "" "" "" "" "" "50.0" "52.6" "41.5" "45.4" "46.9" "42.6" "46.6" "49.9" "51.3" "158.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6449517754761536848" "False" "High" "IsMasterProtein" "O95619" "YEATS domain-containing protein 4 OS=Homo sapiens OX=9606 GN=YEATS4 PE=1 SV=1" "0.000" "False" "10.075" "15" "4" "4" "4" "227" "26.5" "8.41" "10.64" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03366" "8089" "ENSG00000127337" "YEATS4" "hsa:8089; O95619; Q9NQD0" "" "HATs acetylate histones; Activation of the TFAP2 (AP-2) family of transcription factors" "2" "0" "1.363" "1.096" "1.307" "1.350" "1.304" "1.275" "1.112" "1.180" "2.529" "145.6" "198.4" "159.5" "190.3" "196.6" "189.8" "185.6" "161.9" "171.8" "368.2" "" "" "" "" "" "" "" "" "" "" "87.1" "103.1" "88.3" "89.4" "91.1" "97.2" "86.3" "72.7" "93.2" "368.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5646887584104105884" "False" "High" "IsMasterProtein" "Q9BW61" "DET1- and DDB1-associated protein 1 OS=Homo sapiens OX=9606 GN=DDA1 PE=1 SV=1" "0.000" "False" "10.070" "25" "2" "6" "2" "102" "11.8" "8.68" "23.21" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf10172" "79016" "ENSG00000130311" "DDA1" "hsa:79016; Q9BW61" "" "Neddylation" "1" "0" "1.106" "1.151" "1.174" "1.152" "1.189" "1.177" "1.240" "1.262" "1.224" "279.7" "309.5" "322.0" "328.5" "322.3" "332.6" "329.2" "346.9" "353.0" "342.3" "" "" "" "" "" "" "" "" "" "" "167.4" "160.8" "178.3" "154.2" "149.4" "170.3" "153.1" "155.8" "191.5" "342.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-443661170883717287" "False" "High" "IsMasterProtein" "Q9NQ92" "Coordinator of PRMT5 and differentiation stimulator OS=Homo sapiens OX=9606 GN=COPRS PE=1 SV=3" "0.000" "False" "10.057" "24" "3" "5" "3" "184" "20.1" "4.18" "8.03" "3" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf15340" "55352" "ENSG00000172301" "COPRS" "A6NP14; E1P656; hsa:55352; Q96EF5; Q96P75; Q9NQ92" "NF1 copy number variation syndrome" "RMTs methylate histone arginines" "2" "0" "0.937" "0.826" "1.053" "1.098" "0.963" "1.131" "1.142" "1.132" "0.558" "82.8" "77.6" "68.4" "87.2" "90.9" "79.8" "93.6" "94.6" "93.7" "46.2" "" "" "" "" "" "" "" "" "" "" "49.6" "40.3" "37.9" "40.9" "42.1" "40.8" "43.5" "42.5" "50.9" "46.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1414945439185658993" "False" "High" "IsMasterProtein" "P84090" "Enhancer of rudimentary homolog OS=Homo sapiens OX=9606 GN=ERH PE=1 SV=1" "0.000" "False" "10.055" "27" "2" "4" "2" "104" "12.3" "5.92" "11.64" "2" "cell cycle OR cell proliferation;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01133" "2079" "ENSG00000100632" "ERH" "B2R5H2; hsa:2079; P70659; P84090; Q14259" "" "" "0" "0" "0.883" "1.033" "0.861" "0.901" "0.970" "0.812" "0.881" "1.061" "0.431" "245.9" "217.2" "254.1" "211.7" "221.7" "238.5" "199.8" "216.8" "261.0" "106.0" "" "" "" "" "" "" "" "" "" "" "147.2" "112.9" "140.7" "99.4" "102.8" "122.1" "92.9" "97.3" "141.6" "106.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8044840362148842225" "False" "High" "IsMasterProtein" "O95376" "E3 ubiquitin-protein ligase ARIH2 OS=Homo sapiens OX=9606 GN=ARIH2 PE=1 SV=1" "0.000" "False" "10.052" "9" "3" "5" "3" "493" "57.8" "5.63" "12.56" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01485, Pf19422" "10425" "ENSG00000177479" "ARIH2" "hsa:10425; O95376; Q9HBZ6; Q9UEM9" "Modulators of TCR signaling and T cell activation" "Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.226" "0.901" "1.077" "1.179" "1.143" "1.040" "1.223" "0.739" "0.750" "55.6" "68.2" "50.1" "59.9" "65.5" "63.6" "57.8" "68.0" "41.1" "41.7" "" "" "" "" "" "" "" "" "" "" "33.3" "35.4" "27.8" "28.1" "30.4" "32.5" "26.9" "30.5" "22.3" "41.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3819481250379265452" "False" "High" "IsMasterProtein" "Q5JWF2" "Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas OS=Homo sapiens OX=9606 GN=GNAS PE=1 SV=2" "0.000" "False" "10.033" "4" "3" "4" "2" "1037" "111.0" "5.03" "7.39" "3" "cell adhesion;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00503" "2778" "ENSG00000087460" "GNAS" "A2A2S3; E1P5G3; O75684; O75685; Q5JW67; Q5JWF1; Q5JWF2; Q9NY42" "Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; G protein signaling pathways; Thermogenesis; Hippo signaling regulation pathways; Purinergic signaling; GPR143 in melanocytes and retinal pigment epithelium cells; Vasopressin-regulated water reabsorption; Prostaglandin and leukotriene metabolism in senescence ; Primary ovarian insufficiency; Prostaglandin and leukotriene metabolism in senescence ; Calcium regulation in cardiac cells; Estrogen signaling pathway; Serotonin receptor 4/6/7 and NR3C signaling" "G alpha (i) signalling events; G alpha (z) signalling events; G alpha (s) signalling events; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Prostacyclin signalling through prostacyclin receptor; Glucagon-type ligand receptors; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation in glucagon signalling; Hedgehog 'off' state" "29" "0" "1.313" "1.074" "0.884" "1.424" "0.851" "1.340" "1.790" "1.397" "1.592" "22.7" "29.8" "24.4" "20.1" "32.4" "19.3" "30.5" "40.7" "31.8" "36.2" "" "" "" "" "" "" "" "" "" "" "13.6" "15.5" "13.5" "9.4" "15.0" "9.9" "14.2" "18.3" "17.2" "36.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7984641138409737976" "False" "High" "IsMasterProtein" "Q9BXK5" "Bcl-2-like protein 13 OS=Homo sapiens OX=9606 GN=BCL2L13 PE=1 SV=1" "0.000" "False" "10.020" "7" "2" "3" "2" "485" "52.7" "4.44" "6.29" "2" "other biological processes" "other membranes;mitochondrion;nucleus" "enzyme regulator activity" "Pf00452" "23786" "ENSG00000099968" "BCL2L13" "B3KPE7; hsa:23786; Q96B37; Q96IB7; Q9BXK5; Q9BY01; Q9HC05; Q9UFE0; Q9UKN3" "Regulation of apoptosis by parathyroid hormone-related protein; TAR syndrome" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3441790046039018783" "False" "High" "IsMasterProtein" "Q9UQN3" "Charged multivesicular body protein 2b OS=Homo sapiens OX=9606 GN=CHMP2B PE=1 SV=1" "0.000" "False" "10.012" "12" "3" "3" "3" "213" "23.9" "8.76" "9.45" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "25978" "ENSG00000083937" "CHMP2B" "B4DJG8; hsa:25978; Q53HC7; Q9UQN3; Q9Y4U6" "" "Pyroptosis; Macroautophagy; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III; Late endosomal microautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "9" "0" "1.152" "1.122" "0.939" "1.171" "1.010" "1.016" "1.155" "1.169" "0.765" "154.6" "178.1" "173.5" "145.2" "181.0" "156.2" "157.1" "178.7" "180.7" "118.2" "" "" "" "" "" "" "" "" "" "" "92.5" "92.5" "96.1" "68.2" "83.9" "80.0" "73.0" "80.2" "98.0" "118.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2375108519350628678" "False" "High" "IsMasterProtein" "Q13547" "Histone deacetylase 1 OS=Homo sapiens OX=9606 GN=HDAC1 PE=1 SV=1" "0.000" "False" "10.003" "7" "4" "4" "3" "482" "55.1" "5.48" "11.28" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850" "3065" "ENSG00000116478" "HDAC1" "hsa:3065; Q13547; Q92534" "Androgen receptor signaling pathway; Energy metabolism; Cell cycle; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Retinoblastoma gene in cancer; Notch signaling; Apoptosis-related network due to altered Notch3 in ovarian cancer; Initiation of transcription and translation elongation at the HIV-1 LTR; MECP2 and associated Rett syndrome; IL6 signaling pathway; TGF-beta signaling pathway; Valproic acid pathway; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Rett syndrome; Effect of progerin on genes involved in progeria; Ciliary landscape; Transcription co-factors SKI and SKIL protein partners; Overlap between signal transduction pathways contributing to LMNA laminopathies; Opioid receptor pathways; 15q11q13 copy number variation; Notch signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "Potential therapeutics for SARS; Estrogen-dependent gene expression; SUMOylation of chromatin organization proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Formation of the beta-catenin:TCF transactivating complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of PTEN gene transcription; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; MECP2 regulates transcription of neuronal ligands; Factors involved in megakaryocyte development and platelet production; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RNA Polymerase I Transcription Initiation; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of MECP2 expression and activity; STAT3 nuclear events downstream of ALK signaling; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; G1/S-Specific Transcription; Regulation of TP53 Activity through Acetylation; Transcription of E2F targets under negative control by DREAM complex; Nuclear events stimulated by ALK signaling in cancer; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; MECP2 regulates neuronal receptors and channels; Repression of WNT target genes; Loss of MECP2 binding ability to 5mC-DNA" "56" "1" "0.989" "1.083" "0.990" "0.939" "1.013" "0.997" "0.591" "0.927" "4.221" "262.9" "260.0" "284.8" "260.4" "246.9" "266.3" "262.2" "155.5" "243.8" "1109.8" "" "" "" "" "" "" "" "" "" "" "157.4" "135.1" "157.7" "122.2" "114.4" "136.3" "121.9" "69.8" "132.3" "1109.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2749057131699299074" "False" "High" "IsMasterProtein" "Q9BSY4" "Coiled-coil-helix-coiled-coil-helix domain-containing protein 5 OS=Homo sapiens OX=9606 GN=CHCHD5 PE=1 SV=1" "0.000" "False" "9.996" "37" "3" "3" "3" "110" "12.4" "6.73" "5.02" "3" "other metabolic processes" "mitochondrion" "" "Pf06747, Pf16860" "84269" "ENSG00000125611" "CHCHD5" "hsa:84269; Q585T4; Q8N8C4; Q9BSY4" "2q13 copy number variation syndrome" "Mitochondrial protein import" "2" "0" "1.001" "0.992" "1.321" "1.332" "1.279" "1.190" "1.128" "0.971" "1.013" "41.6" "41.7" "41.3" "55.0" "55.4" "53.2" "49.5" "47.0" "40.4" "42.2" "" "" "" "" "" "" "" "" "" "" "24.9" "21.6" "22.9" "25.8" "25.7" "27.2" "23.0" "21.1" "21.9" "42.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4459435427997336669" "False" "High" "IsMasterProtein" "O60231" "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 OS=Homo sapiens OX=9606 GN=DHX16 PE=1 SV=2" "0.000" "False" "9.989" "3" "3" "4" "3" "1041" "119.2" "6.80" "5.23" "3" "RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "8449" "ENSG00000204560; ENSG00000206486; ENSG00000226171; ENSG00000231377; ENSG00000233049; ENSG00000233418; ENSG00000233561" "DHX16" "hsa:8449; O60231; O60322; Q5JP45; Q969X7; Q96QC1" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.248" "0.904" "1.162" "1.074" "1.232" "1.222" "1.088" "1.093" "1.877" "77.5" "96.7" "70.0" "90.1" "83.2" "95.5" "94.7" "84.3" "84.7" "145.5" "" "" "" "" "" "" "" "" "" "" "46.4" "50.2" "38.8" "42.3" "38.6" "48.9" "44.0" "37.8" "45.9" "145.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5428916693947129614" "False" "High" "IsMasterProtein" "Q92556" "Engulfment and cell motility protein 1 OS=Homo sapiens OX=9606 GN=ELMO1 PE=1 SV=2" "0.000" "False" "9.981" "5" "4" "4" "4" "727" "83.8" "6.28" "10.40" "4" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf04727, Pf11841, Pf16457" "9844" "ENSG00000155849" "ELMO1" "A4D1X6; hsa:9844; Q29R79; Q6ZTJ0; Q92556; Q96PB0; Q9H0I1" "Chemokine signaling pathway; CCL18 signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Nef and signal transduction" "7" "0" "0.969" "1.176" "1.196" "1.095" "1.156" "1.368" "0.552" "0.881" "4.954" "70.7" "68.5" "83.2" "84.6" "77.5" "81.8" "96.7" "39.0" "62.3" "350.5" "" "" "" "" "" "" "" "" "" "" "42.3" "35.6" "46.1" "39.7" "35.9" "41.9" "45.0" "17.5" "33.8" "350.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-204711257539491149" "False" "High" "IsMasterProtein" "O96017" "Serine/threonine-protein kinase Chk2 OS=Homo sapiens OX=9606 GN=CHEK2 PE=1 SV=1" "0.000" "False" "9.946" "7" "4" "4" "4" "543" "60.9" "5.91" "7.84" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00498" "11200" "ENSG00000183765" "CHEK2" "A8K3Y9; B7ZBF3; B7ZBF4; B7ZBF5; hsa:11200; O96017; Q6QA03; Q6QA04; Q6QA05; Q6QA06; Q6QA07; Q6QA08; Q6QA10; Q6QA11; Q6QA12; Q6QA13; Q9HBS5; Q9HCQ8; Q9UGF0; Q9UGF1" "miRNA regulation of DNA damage response; Cell cycle; ATM signaling in development and disease ; miRNA regulation of p53 pathway in prostate cancer; DNA damage response" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Regulation of TP53 Activity through Methylation; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Stabilization of p53" "13" "0" "0.916" "0.810" "0.963" "1.008" "0.913" "1.060" "0.862" "0.889" "1.680" "176.4" "161.6" "142.9" "169.8" "177.7" "161.0" "186.9" "152.1" "156.7" "296.3" "" "" "" "" "" "" "" "" "" "" "105.5" "84.0" "79.1" "79.7" "82.4" "82.4" "86.9" "68.3" "85.0" "296.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8833094404749326966" "False" "High" "IsMasterProtein" "Q9Y285" "Phenylalanine--tRNA ligase alpha subunit OS=Homo sapiens OX=9606 GN=FARSA PE=1 SV=3" "0.000" "False" "9.946" "9" "4" "5" "4" "508" "57.5" "7.80" "7.52" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01409, Pf18552, Pf18553, Pf18554" "2193" "ENSG00000179115" "FARSA" "B4E363; hsa:2193; Q9NSD8; Q9Y285; Q9Y4W8" "" "Cytosolic tRNA aminoacylation" "1" "0" "1.258" "1.253" "1.259" "1.556" "1.257" "1.183" "0.264" "1.030" "9.285" "48.6" "61.1" "60.9" "61.1" "75.6" "61.0" "57.5" "12.8" "50.0" "451.1" "" "" "" "" "" "" "" "" "" "" "29.1" "31.7" "33.7" "28.7" "35.0" "31.3" "26.7" "5.8" "27.1" "451.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8505612402410571852" "False" "High" "IsMasterProtein" "P17900" "Ganglioside GM2 activator OS=Homo sapiens OX=9606 GN=GM2A PE=1 SV=4" "0.000" "False" "9.936" "9" "2" "8" "2" "193" "20.8" "5.31" "24.92" "2" "other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;enzyme regulator activity;other molecular function" "Pf02221" "2760" "ENSG00000196743" "GM2A" "B2R699; D3DQH6; hsa:2760; P17900; Q14426; Q14428; Q6LBL5" "Degradation pathway of sphingolipids, including diseases" "Neutrophil degranulation; Glycosphingolipid catabolism" "3" "0" "0.997" "1.037" "0.975" "1.111" "1.044" "1.278" "1.089" "1.159" "0.583" "429.3" "428.1" "445.0" "418.4" "476.7" "448.3" "548.4" "467.3" "497.7" "250.2" "" "" "" "" "" "" "" "" "" "" "256.9" "222.5" "246.4" "196.4" "221.0" "229.5" "255.0" "209.8" "270.0" "250.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-729542664091126034" "False" "High" "IsMasterProtein" "Q93008" "Ubiquitin carboxyl-terminal hydrolase 9X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=4" "0.000" "False" "9.923" "1" "2" "3" "2" "2554" "290.3" "5.80" "10.24" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00443, Pf12030" "8239" "ENSG00000124486" "USP9X" "hsa:8239; O75550; Q8WWT3; Q8WX12; Q93008" "Ciliopathies; Bardet-Biedl syndrome" "Ub-specific processing proteases; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Amyloid fiber formation; Peroxisomal protein import; RHOV GTPase cycle; RHOU GTPase cycle" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1749791296604860145" "False" "High" "IsMasterProtein" "Q9BTE6" "Alanyl-tRNA editing protein Aarsd1 OS=Homo sapiens OX=9606 GN=AARSD1 PE=1 SV=2" "0.000" "False" "9.916" "10" "4" "4" "4" "412" "45.5" "6.42" "7.95" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf07973" "100885850; 80755" "ENSG00000108825; ENSG00000266967" "AARSD1" "B4DI73; hsa:100885850; hsa:80755; Q9BTE6" "" "" "0" "0" "1.048" "1.188" "1.327" "1.357" "1.407" "1.435" "1.132" "1.057" "3.136" "65.5" "68.7" "77.8" "87.0" "88.9" "92.2" "94.0" "74.1" "69.2" "205.5" "" "" "" "" "" "" "" "" "" "" "39.2" "35.7" "43.1" "40.8" "41.2" "47.2" "43.7" "33.3" "37.6" "205.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8811809090486028216" "False" "High" "IsMasterProtein" "Q6QNY0" "Biogenesis of lysosome-related organelles complex 1 subunit 3 OS=Homo sapiens OX=9606 GN=BLOC1S3 PE=1 SV=1" "0.000" "False" "9.902" "18" "2" "2" "2" "202" "21.2" "5.15" "8.46" "2" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "cytosol;ER/Golgi;other cell component" "transporter activity" "Pf15753" "388552" "ENSG00000189114" "BLOC1S3" "B2RXB8; hsa:388552; Q6QNY0" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8315542899134672596" "False" "High" "IsMasterProtein" "O94804" "Serine/threonine-protein kinase 10 OS=Homo sapiens OX=9606 GN=STK10 PE=1 SV=1" "0.000" "False" "9.899" "5" "4" "5" "4" "968" "112.1" "6.95" "3.40" "4" "cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12474" "6793" "ENSG00000072786" "STK10" "A6ND35; B2R8F5; B3KMY1; hsa:6793; O94804; Q6NSK0; Q9UIW4" "" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Neutrophil degranulation" "4" "0" "0.871" "0.929" "0.950" "0.682" "0.850" "0.848" "0.574" "0.842" "3.774" "49.8" "43.4" "46.3" "47.3" "34.0" "42.3" "42.2" "28.6" "41.9" "187.9" "" "" "" "" "" "" "" "" "" "" "29.8" "22.5" "25.6" "22.2" "15.7" "21.7" "19.6" "12.8" "22.7" "187.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7900354501110065761" "False" "High" "IsMasterProtein" "O00170" "AH receptor-interacting protein OS=Homo sapiens OX=9606 GN=AIP PE=1 SV=3" "0.000" "False" "9.896" "8" "2" "3" "2" "330" "37.6" "6.42" "12.75" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00254" "9049" "ENSG00000110711" "AIP" "A0SZW3; A0SZW4; A0SZW5; A0SZW6; G9I2H4; hsa:9049; O00170; Q2M3Q2; Q99606" "Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway" "Aryl hydrocarbon receptor signalling; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "5" "0" "1.278" "1.784" "1.682" "1.502" "1.334" "1.340" "1.101" "1.569" "4.514" "40.2" "51.4" "71.8" "67.7" "60.4" "53.7" "53.9" "44.3" "63.2" "181.7" "" "" "" "" "" "" "" "" "" "" "24.1" "26.7" "39.8" "31.8" "28.0" "27.5" "25.1" "19.9" "34.3" "181.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7181785604482644820" "False" "High" "IsMasterProtein" "Q9NR50" "Translation initiation factor eIF2B subunit gamma OS=Homo sapiens OX=9606 GN=EIF2B3 PE=1 SV=1" "0.000" "False" "9.857" "6" "3" "3" "3" "452" "50.2" "6.47" "5.90" "3" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00483" "8891" "ENSG00000070785" "EIF2B3" "B2RBH8; D3DPZ2; hsa:8891; Q5QP89; Q5QP90; Q8NDB5; Q8WV57; Q9H850; Q9NR50" "Translation factors; Primary ovarian insufficiency" "Recycling of eIF2:GDP" "3" "0" "1.676" "1.784" "1.596" "1.024" "1.172" "0.994" "1.265" "1.286" "1.413" "22.9" "38.5" "40.9" "36.6" "23.5" "26.9" "22.8" "29.0" "29.5" "32.4" "" "" "" "" "" "" "" "" "" "" "13.7" "20.0" "22.7" "17.2" "10.9" "13.8" "10.6" "13.0" "16.0" "32.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-536665306058471520" "False" "High" "IsMasterProtein" "Q07020" "Large ribosomal subunit protein eL18 OS=Homo sapiens OX=9606 GN=RPL18 PE=1 SV=2" "0.000" "False" "9.855" "11" "2" "4" "2" "188" "21.6" "11.72" "13.87" "2" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf17135" "6141" "ENSG00000063177" "RPL18" "F8VWC5; hsa:6141; Q07020; Q8WTZ6" "Cytoplasmic ribosomal proteins" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.922" "1.061" "1.031" "1.006" "1.030" "0.993" "1.035" "1.054" "1.388" "373.1" "343.9" "395.7" "384.7" "375.3" "384.3" "370.5" "386.0" "393.4" "517.9" "" "" "" "" "" "" "" "" "" "" "223.3" "178.7" "219.1" "180.6" "174.0" "196.7" "172.3" "173.3" "213.4" "517.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2631004439744677845" "False" "High" "IsMasterProtein" "P04637" "Cellular tumor antigen p53 OS=Homo sapiens OX=9606 GN=TP53 PE=1 SV=4" "0.000" "False" "9.855" "9" "3" "3" "3" "393" "43.6" "6.79" "5.80" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00870, Pf07710, Pf08563, Pf18521" "7157" "ENSG00000141510" "TP53" "hsa:7157; P04637; Q15086; Q15087; Q15088; Q16535; Q16807; Q16808; Q16809; Q16810; Q16811; Q16848; Q2XN98; Q3LRW1; Q3LRW2; Q3LRW3; Q3LRW4; Q3LRW5; Q86UG1; Q8J016; Q99659; Q9BTM4; Q9HAQ8; Q9NP68; Q9NPJ2; Q9NZD0; Q9UBI2; Q9UQ61" "AMP-activated protein kinase signaling; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Fluoropyrimidine activity; TP53 network; Folate metabolism; Apoptosis modulation and signaling; Cell cycle; Metastatic brain tumor; Glioblastoma signaling pathways; Gastric cancer network 2; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Amyotrophic lateral sclerosis (ALS); ATM signaling pathway; Apoptosis; Mammary gland development pathway - Involution (Stage 4 of 4); Bladder cancer; Copper homeostasis; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Hepatitis C and hepatocellular carcinoma; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; lncRNA-mediated mechanisms of therapeutic resistance; MAPK signaling pathway; miRNA regulation of prostate cancer signaling pathways; miRNA regulation of p53 pathway in prostate cancer; Wnt signaling pathway and pluripotency; Endometrial cancer; PI3K-Akt signaling pathway; Caloric restriction and aging; Hereditary leiomyomatosis and renal cell carcinoma pathway; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer; Ferroptosis; Effect of progerin on genes involved in progeria; MicroRNA network associated with chronic lymphocytic leukemia; G1 to S cell cycle control; Measles virus infection; 22q11.2 copy number variation syndrome; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Unfolded protein response; 16p11.2 proximal deletion syndrome; Pentose phosphate pathway in senescent cells; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; TCA cycle in senescence; Pleural mesothelioma; Lipid metabolism in senescent cells; DYRK1A involvement regarding cell proliferation in brain development; 2q37 copy number variation syndrome; Autophagy in pancreatic ductal adenocarcinoma; 11p11.2 copy number variation syndrome ; Macrophage-stimulating protein (MSP) signaling network map; 8q11.23 (RB1CC1) copy number variation; Omega-6-fatty acids in senescence; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)" "TP53 Regulates Transcription of DNA Repair Genes; Zygotic genome activation (ZGA); TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Autodegradation of the E3 ubiquitin ligase COP1; Ub-specific processing proteases; The role of GTSE1 in G2/M progression after G2 checkpoint; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; PKR-mediated signaling; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TP53 Regulates Transcription of Death Receptors and Ligands; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Regulation of TP53 Activity through Phosphorylation; Signaling by ALK fusions and activated point mutants; TP53 Regulates Metabolic Genes; Association of TriC/CCT with target proteins during biosynthesis; Interleukin-4 and Interleukin-13 signaling; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Factors involved in megakaryocyte development and platelet production; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of TP53 Activity through Methylation; G2/M DNA damage checkpoint; Regulation of NF-kappa B signaling; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; Regulation of TP53 Activity through Association with Co-factors; Ovarian tumor domain proteases; Pyroptosis; SUMOylation of transcription factors; Regulation of TP53 Expression; RUNX3 regulates CDKN1A transcription; Activation of NOXA and translocation to mitochondria; Formation of Senescence-Associated Heterochromatin Foci (SAHF); PI5P Regulates TP53 Acetylation; Transcriptional activation of cell cycle inhibitor p21 ; Loss of function of TP53 in cancer due to loss of tetramerization ability" "116" "0" "1.043" "1.395" "1.623" "1.148" "1.446" "1.311" "1.239" "1.290" "1.774" "30.0" "31.3" "41.8" "48.7" "34.4" "43.4" "39.3" "37.2" "38.7" "53.2" "" "" "" "" "" "" "" "" "" "" "18.0" "16.3" "23.2" "22.9" "16.0" "22.2" "18.3" "16.7" "21.0" "53.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5853240527723212968" "False" "High" "IsMasterProtein" "Q9H7Z7" "Prostaglandin E synthase 2 OS=Homo sapiens OX=9606 GN=PTGES2 PE=1 SV=1" "0.000" "False" "9.826" "7" "3" "3" "3" "377" "41.9" "9.16" "9.94" "3" "other metabolic processes;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf13410, Pf13417" "80142" "ENSG00000148334" "PTGES2" "hsa:80142; Q53EW9; Q5SYV6; Q96GI0; Q96GL2; Q9H7Z7" "Relationship between inflammation, COX-2 and EGFR; Omega-6-fatty acids in senescence" "Neutrophil degranulation; Synthesis of Prostaglandins (PG) and Thromboxanes (TX)" "4" "0" "1.170" "1.032" "1.285" "1.271" "1.055" "1.051" "1.130" "1.082" "0.878" "189.1" "221.2" "195.2" "243.0" "240.3" "199.4" "198.7" "213.8" "204.6" "166.0" "" "" "" "" "" "" "" "" "" "" "113.2" "114.9" "108.1" "114.1" "111.4" "102.1" "92.4" "96.0" "111.0" "166.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8924414405991965446" "False" "High" "IsMasterProtein" "P98179" "RNA-binding protein 3 OS=Homo sapiens OX=9606 GN=RBM3 PE=1 SV=1" "0.000" "False" "9.819" "16" "2" "9" "2" "157" "17.2" "8.91" "19.69" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity" "Pf00076" "5935" "ENSG00000102317" "RBM3" "hsa:5935; P98179" "" "" "0" "0" "1.033" "1.007" "0.921" "1.036" "1.019" "1.097" "0.938" "0.985" "0.738" "99.0" "102.3" "99.6" "91.2" "102.5" "100.9" "108.6" "92.8" "97.5" "73.1" "" "" "" "" "" "" "" "" "" "" "59.2" "53.2" "55.2" "42.8" "47.5" "51.6" "50.5" "41.7" "52.9" "73.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6764282473727919069" "False" "High" "IsMasterProtein" "Q96K17" "Transcription factor BTF3 homolog 4 OS=Homo sapiens OX=9606 GN=BTF3L4 PE=1 SV=1" "0.000" "False" "9.815" "22" "3" "3" "2" "158" "17.3" "6.35" "7.70" "3" "" "" "" "Pf01849" "91408" "ENSG00000134717" "BTF3L4" "B3KNJ1; D3DQ32; G3V1C6; hsa:91408; Q96K17" "" "" "0" "0" "1.122" "1.160" "1.014" "1.165" "1.132" "1.200" "1.012" "1.188" "0.801" "235.6" "264.3" "273.4" "238.9" "274.4" "266.8" "282.9" "238.5" "280.0" "188.7" "" "" "" "" "" "" "" "" "" "" "141.0" "137.3" "151.4" "112.2" "127.2" "136.6" "131.5" "107.1" "151.9" "188.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5860856138791644160" "False" "High" "IsMasterProtein" "Q9Y5A9" "YTH domain-containing family protein 2 OS=Homo sapiens OX=9606 GN=YTHDF2 PE=1 SV=2" "0.000" "False" "9.805" "5" "3" "3" "1" "579" "62.3" "8.79" "9.70" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04146" "51441" "ENSG00000198492" "YTHDF2" "A6NKG4; A8K966; B4E1G7; D3DPM8; hsa:51441; Q5VSZ9; Q8TDH0; Q9BUJ5; Q9Y5A9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5166856508772248001" "False" "High" "IsMasterProtein" "P01111" "GTPase NRas OS=Homo sapiens OX=9606 GN=NRAS PE=1 SV=1" "0.000" "False" "9.790" "11" "2" "3" "2" "189" "21.2" "5.17" "7.12" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00071" "4893" "ENSG00000213281" "NRAS" "hsa:4893; P01111; Q14971; Q15104; Q15282" "Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; JAK-STAT signaling in the regulation of beta cells; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling" "Neutrophil degranulation; FCERI mediated MAPK activation; Regulation of RAS by GAPs; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 in disease; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; Signaling by RAS GAP mutants; Signaling by RAS GTPase mutants" "110" "0" "0.841" "1.189" "0.605" "0.770" "0.679" "0.877" "0.906" "1.053" "0.461" "40.1" "33.7" "47.7" "24.3" "30.9" "27.2" "35.2" "36.4" "42.3" "18.5" "" "" "" "" "" "" "" "" "" "" "24.0" "17.5" "26.4" "11.4" "14.3" "13.9" "16.4" "16.3" "22.9" "18.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6049442156646566229" "False" "High" "IsMasterProtein" "Q6UXN9" "WD repeat-containing protein 82 OS=Homo sapiens OX=9606 GN=WDR82 PE=1 SV=1" "0.000" "False" "9.781" "9" "3" "5" "3" "313" "35.1" "7.69" "14.68" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400" "80335" "ENSG00000164091" "WDR82" "A8K5R5; hsa:80335; Q6UXN9; Q8TEB2" "" "Formation of WDR5-containing histone-modifying complexes" "1" "0" "0.993" "0.977" "0.971" "0.939" "1.057" "0.934" "1.126" "0.991" "0.935" "546.8" "542.9" "534.1" "530.7" "513.3" "577.8" "510.8" "615.8" "542.1" "511.4" "" "" "" "" "" "" "" "" "" "" "327.2" "282.1" "295.8" "249.2" "237.9" "295.8" "237.5" "276.4" "294.1" "511.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9153257875265109999" "False" "High" "IsMasterProtein" "Q9NYJ1" "Cytochrome c oxidase assembly factor 4 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=COA4 PE=1 SV=2" "0.000" "False" "9.780" "24" "2" "3" "2" "87" "10.1" "6.04" "8.19" "2" "cell organization and biogenesis" "mitochondrion" "" "Pf06747" "51287" "ENSG00000181924" "COA4" "B2RAA0; hsa:51287; Q69YU4; Q9NYJ1" "" "Mitochondrial protein import" "1" "0" "1.156" "1.080" "1.247" "1.609" "1.245" "1.764" "2.118" "1.243" "0.927" "18.1" "20.9" "19.6" "22.6" "29.1" "22.6" "31.9" "38.4" "22.5" "16.8" "" "" "" "" "" "" "" "" "" "" "10.8" "10.9" "10.8" "10.6" "13.5" "11.5" "14.9" "17.2" "12.2" "16.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2886709730536475345" "False" "High" "IsMasterProtein" "Q9BTT0" "Acidic leucine-rich nuclear phosphoprotein 32 family member E OS=Homo sapiens OX=9606 GN=ANP32E PE=1 SV=1" "0.000" "False" "9.773" "4" "1" "2" "1" "268" "30.7" "3.85" "6.39" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf14580" "81611" "ENSG00000143401" "ANP32E" "B4E0I6; E9PEA6; hsa:81611; Q5TB18; Q5TB20; Q8N1S4; Q8WWW9; Q9BTT0" "" "" "0" "0" "0.867" "1.706" "1.207" "1.139" "0.819" "0.741" "0.563" "1.226" "4.849" "40.1" "34.7" "68.3" "48.4" "45.6" "32.8" "29.7" "22.6" "49.1" "194.3" "" "" "" "" "" "" "" "" "" "" "24.0" "18.1" "37.8" "22.7" "21.2" "16.8" "13.8" "10.1" "26.7" "194.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5370453687865171634" "False" "High" "IsMasterProtein" "P39880" "Homeobox protein cut-like 1 OS=Homo sapiens OX=9606 GN=CUX1 PE=1 SV=3" "0.000" "False" "9.768" "3" "4" "4" "4" "1505" "164.1" "5.90" "6.75" "4" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf02376" "1523" "ENSG00000257923" "CUX1" "B3KV79; J3KQV9; P39880; Q6NYH4; Q75LE5; Q75MT2; Q75MT3; Q86UJ7; Q9UEV5" "" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "2" "0" "1.407" "1.323" "1.174" "1.079" "1.710" "1.816" "0.974" "1.083" "4.578" "36.0" "50.7" "47.7" "42.3" "38.9" "61.6" "65.4" "35.1" "39.0" "165.0" "" "" "" "" "" "" "" "" "" "" "21.6" "26.4" "26.4" "19.9" "18.0" "31.6" "30.4" "15.8" "21.2" "165.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8263646129409186084" "False" "High" "IsMasterProtein" "Q14814" "Myocyte-specific enhancer factor 2D OS=Homo sapiens OX=9606 GN=MEF2D PE=1 SV=1" "0.000" "False" "9.757" "7" "4" "5" "2" "521" "55.9" "7.88" "13.21" "4" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4209" "ENSG00000116604; ENSG00000291761" "MEF2D" "D3DVC0; hsa:4209; Q14814; Q14815; Q5T9U5; Q5T9U6" "Energy metabolism; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; B cell receptor signaling pathway; Adipogenesis; p38 MAPK signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; EGF/EGFR signaling pathway; Gastrin signaling pathway; Modulators of TCR signaling and T cell activation; Pleural mesothelioma; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "Heme signaling; NGF-stimulated transcription; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Myogenesis" "18" "1" "1.056" "1.156" "1.052" "1.213" "1.219" "1.332" "1.073" "1.050" "1.276" "73.0" "77.0" "84.4" "76.8" "88.5" "89.0" "97.2" "78.3" "76.6" "93.1" "" "" "" "" "" "" "" "" "" "" "43.7" "40.0" "46.7" "36.0" "41.0" "45.6" "45.2" "35.2" "41.6" "93.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6073254106150692843" "False" "High" "IsMasterProtein" "Q99575" "Ribonucleases P/MRP protein subunit POP1 OS=Homo sapiens OX=9606 GN=POP1 PE=1 SV=2" "0.000" "False" "9.745" "5" "4" "4" "4" "1024" "114.6" "9.22" "6.65" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06978, Pf08170" "10940" "ENSG00000104356" "POP1" "A8K5W9; Q15037; Q99575" "" "tRNA processing in the nucleus" "1" "0" "1.107" "1.045" "1.096" "1.390" "1.138" "1.160" "1.274" "1.044" "1.015" "44.2" "48.9" "46.2" "48.5" "61.4" "50.3" "51.3" "56.3" "46.1" "44.9" "" "" "" "" "" "" "" "" "" "" "26.4" "25.4" "25.6" "22.8" "28.5" "25.8" "23.8" "25.3" "25.0" "44.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6008736440558391918" "False" "High" "IsMasterProtein" "O75157" "TSC22 domain family protein 2 OS=Homo sapiens OX=9606 GN=TSC22D2 PE=1 SV=3" "0.000" "False" "9.734" "4" "3" "4" "2" "780" "79.2" "5.02" "12.05" "3" "stress response;other biological processes" "" "" "Pf01166" "9819" "ENSG00000196428" "TSC22D2" "D3DNI5; hsa:9819; O75157; Q6PI50; Q9H2Z6; Q9H2Z7; Q9H2Z8" "" "" "0" "0" "0.953" "0.959" "0.870" "0.897" "0.950" "0.966" "0.944" "1.026" "0.635" "151.6" "144.5" "145.4" "132.0" "136.0" "144.0" "146.4" "143.2" "155.6" "96.2" "" "" "" "" "" "" "" "" "" "" "90.7" "75.1" "80.5" "62.0" "63.0" "73.7" "68.1" "64.3" "84.4" "96.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "687508345564059484" "False" "High" "IsMasterProtein" "Q15436" "Protein transport protein Sec23A OS=Homo sapiens OX=9606 GN=SEC23A PE=1 SV=2" "0.000" "False" "9.733" "3" "2" "6" "1" "765" "86.1" "7.08" "17.72" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10484" "ENSG00000100934" "SEC23A" "B2R5P4; B3KXI2; hsa:10484; Q15436; Q8NE16" "Sterol regulatory element-binding proteins (SREBP) signaling" "MHC class II antigen presentation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; SARS-CoV-2 activates/modulates innate and adaptive immune responses; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF)" "7" "0" "0.881" "0.848" "1.146" "1.206" "0.654" "0.998" "0.952" "1.001" "2.017" "33.4" "29.5" "28.4" "38.3" "40.3" "21.9" "33.4" "31.8" "33.5" "67.4" "" "" "" "" "" "" "" "" "" "" "20.0" "15.3" "15.7" "18.0" "18.7" "11.2" "15.5" "14.3" "18.2" "67.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4937271554403891889" "False" "High" "IsMasterProtein" "P16150" "Leukosialin OS=Homo sapiens OX=9606 GN=SPN PE=1 SV=1" "0.000" "False" "9.728" "10" "4" "6" "4" "400" "40.3" "5.10" "15.56" "4" "cell adhesion;cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "" "6693" "ENSG00000197471" "SPN" "A8K9B1; hsa:6693; P16150" "16p11.2 proximal deletion syndrome" "Basigin interactions" "3" "0" "1.019" "0.929" "0.956" "0.941" "0.875" "1.057" "0.994" "0.936" "0.357" "436.2" "444.4" "405.3" "417.1" "410.4" "381.8" "461.2" "433.5" "408.4" "155.9" "" "" "" "" "" "" "" "" "" "" "261.0" "230.9" "224.4" "195.8" "190.2" "195.5" "214.5" "194.6" "221.6" "155.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3695777178307527150" "False" "High" "IsMasterProtein" "Q9BZL1" "Ubiquitin-like protein 5 OS=Homo sapiens OX=9606 GN=UBL5 PE=1 SV=1" "0.000" "False" "9.716" "40" "3" "10" "3" "73" "8.5" "8.44" "24.84" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00240" "59286" "ENSG00000198258" "UBL5" "hsa:59286; Q2NL89; Q9BZL1" "" "mRNA Splicing - Major Pathway" "1" "0" "1.066" "1.235" "1.043" "1.274" "1.141" "1.068" "0.897" "1.135" "2.757" "316.8" "337.6" "391.2" "330.4" "403.5" "361.5" "338.3" "284.3" "359.6" "873.5" "" "" "" "" "" "" "" "" "" "" "189.6" "175.4" "216.6" "155.1" "187.0" "185.1" "157.3" "127.6" "195.1" "873.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6585910940532122349" "False" "High" "IsMasterProtein" "Q5U5X0" "Complex III assembly factor LYRM7 OS=Homo sapiens OX=9606 GN=LYRM7 PE=1 SV=1" "0.000" "False" "9.706" "25" "2" "2" "2" "104" "11.9" "9.66" "7.45" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf05347" "90624" "ENSG00000186687" "LYRM7" "A8MPQ9; hsa:90624; Q5U5X0; Q86Y68" "Mitochondrial complex III assembly" "" "1" "0" "1.036" "0.828" "1.011" "1.024" "0.929" "1.184" "0.780" "0.826" "0.836" "144.9" "150.1" "119.9" "146.4" "148.3" "134.6" "171.5" "113.0" "119.6" "121.1" "" "" "" "" "" "" "" "" "" "" "86.7" "78.0" "66.4" "68.7" "68.7" "68.9" "79.7" "50.7" "64.9" "121.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8213729863308039280" "False" "High" "IsMasterProtein" "Q14331" "Protein FRG1 OS=Homo sapiens OX=9606 GN=FRG1 PE=1 SV=1" "0.000" "False" "9.688" "14" "4" "4" "4" "258" "29.2" "9.01" "8.48" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "cytoskeletal activity" "Pf06229" "2483" "ENSG00000109536; ENSG00000275145; ENSG00000283153; ENSG00000283630" "FRG1" "A8K775; hsa:2483; Q14331" "" "" "0" "0" "1.116" "1.138" "1.072" "0.915" "1.074" "1.028" "1.037" "1.185" "1.339" "157.5" "175.9" "179.3" "168.9" "144.2" "169.1" "162.0" "163.3" "186.7" "211.0" "" "" "" "" "" "" "" "" "" "" "94.3" "91.4" "99.3" "79.3" "66.8" "86.6" "75.3" "73.3" "101.3" "211.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7689745804882425318" "False" "High" "IsMasterProtein" "Q6XQN6" "Nicotinate phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAPRT PE=1 SV=2" "0.000" "False" "9.674" "5" "3" "3" "3" "538" "57.5" "5.68" "9.29" "3" "other metabolic processes;stress response" "non-structural extracellular;cytosol;other cytoplasmic organelle" "other molecular function" "Pf17767, Pf17956" "93100" "ENSG00000147813; ENSG00000278488" "NAPRT" "A7BFI3; hsa:93100; Q6PJL1; Q6XQN4; Q6XQN5; Q6XQN6; Q8N5E8; Q9BRG0" "NAD+ biosynthetic pathways" "Neutrophil degranulation; Nicotinamide salvaging" "3" "0" "1.091" "0.969" "1.107" "1.125" "1.132" "1.030" "1.013" "1.031" "0.610" "331.4" "361.5" "321.2" "367.0" "372.7" "375.0" "341.3" "335.8" "341.8" "202.2" "" "" "" "" "" "" "" "" "" "" "198.3" "187.9" "177.9" "172.3" "172.7" "192.0" "158.7" "150.7" "185.5" "202.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6664937440056635092" "False" "High" "IsMasterProtein" "Q9BQ48" "Large ribosomal subunit protein bL34m OS=Homo sapiens OX=9606 GN=MRPL34 PE=1 SV=1" "0.000" "False" "9.670" "24" "2" "4" "2" "92" "10.2" "12.25" "11.63" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00468" "64981" "ENSG00000130312" "MRPL34" "hsa:64981; Q9BQ48" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.871" "0.953" "0.881" "0.870" "1.029" "0.906" "0.998" "1.005" "0.338" "121.0" "105.5" "115.3" "106.6" "105.3" "124.6" "109.7" "120.8" "121.6" "40.9" "" "" "" "" "" "" "" "" "" "" "72.4" "54.8" "63.9" "50.1" "48.8" "63.8" "51.0" "54.2" "66.0" "40.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5616510837335031809" "False" "High" "IsMasterProtein" "P15586" "N-acetylglucosamine-6-sulfatase OS=Homo sapiens OX=9606 GN=GNS PE=1 SV=3" "0.000" "False" "9.656" "7" "4" "9" "4" "552" "62.0" "8.31" "18.72" "4" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00884" "2799" "ENSG00000135677" "GNS" "B4DYH8; hsa:2799; P15586; Q53F05" "Glycosaminoglycan degradation" "Lysosome Vesicle Biogenesis; Neutrophil degranulation; Keratan sulfate degradation; MPS IIID - Sanfilippo syndrome D" "5" "0" "0.977" "0.906" "1.196" "1.080" "0.876" "1.173" "0.976" "0.999" "0.670" "111.1" "108.5" "100.7" "132.9" "119.9" "97.3" "130.3" "108.5" "110.9" "74.5" "" "" "" "" "" "" "" "" "" "" "66.5" "56.4" "55.7" "62.4" "55.6" "49.8" "60.6" "48.7" "60.2" "74.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3647234260862617095" "False" "High" "IsMasterProtein" "Q8TEA8" "D-aminoacyl-tRNA deacylase 1 OS=Homo sapiens OX=9606 GN=DTD1 PE=1 SV=2" "0.000" "False" "9.652" "11" "2" "5" "2" "209" "23.4" "8.24" "14.30" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02580" "92675" "ENSG00000125821" "DTD1" "A8K5X5; D3DW37; hsa:92675; Q496D1; Q5W184; Q8TEA8; Q8WXU8; Q9BW67; Q9H464; Q9H474" "" "" "0" "0" "1.072" "1.112" "1.015" "0.888" "1.063" "0.996" "1.091" "1.077" "0.685" "269.9" "289.4" "300.1" "274.0" "239.7" "287.0" "268.8" "294.4" "290.7" "184.8" "" "" "" "" "" "" "" "" "" "" "161.5" "150.4" "166.2" "128.6" "111.1" "146.9" "125.0" "132.2" "157.7" "184.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3480687027944615342" "False" "High" "IsMasterProtein" "Q8NHG8" "E3 ubiquitin-protein ligase ZNRF2 OS=Homo sapiens OX=9606 GN=ZNRF2 PE=1 SV=1" "0.000" "False" "9.640" "19" "3" "3" "3" "242" "24.1" "7.09" "3.57" "3" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13639" "223082" "ENSG00000180233" "ZNRF2" "Q8NHG8" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "741210737454912212" "False" "High" "IsMasterProtein" "Q7Z7A4" "PX domain-containing protein kinase-like protein OS=Homo sapiens OX=9606 GN=PXK PE=1 SV=1" "0.000" "False" "9.629" "6" "3" "3" "3" "578" "64.9" "9.35" "8.04" "3" "stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00787, Pf02205" "54899" "ENSG00000168297" "PXK" "hsa:54899; Q3BCH4; Q3BCH5; Q3BCH6; Q3BDW1; Q45L83; Q59EX3; Q6PK17; Q6ZN39; Q7Z7A4; Q96CA3; Q96R07; Q9NXB8" "" "" "0" "0" "1.107" "1.034" "1.087" "1.117" "1.213" "0.999" "0.870" "1.129" "3.184" "120.3" "133.2" "124.4" "130.8" "134.4" "146.0" "120.3" "104.6" "135.9" "383.1" "" "" "" "" "" "" "" "" "" "" "72.0" "69.2" "68.9" "61.4" "62.3" "74.7" "55.9" "47.0" "73.7" "383.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4144026174049458249" "False" "High" "IsMasterProtein" "Q99574" "Neuroserpin OS=Homo sapiens OX=9606 GN=SERPINI1 PE=1 SV=1" "0.000" "False" "9.619" "12" "5" "6" "5" "410" "46.4" "4.91" "7.71" "5" "developmental processes;other biological processes" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00079" "5274" "ENSG00000163536" "SERPINI1" "A8K217; D3DNP1; hsa:5274; Q6AHZ4; Q99574" "" "" "0" "0" "0.830" "0.957" "0.964" "1.073" "1.015" "1.064" "1.003" "0.871" "0.722" "189.8" "157.5" "181.6" "183.0" "203.6" "192.6" "202.0" "190.3" "165.4" "137.0" "" "" "" "" "" "" "" "" "" "" "113.6" "81.8" "100.6" "85.9" "94.4" "98.6" "93.9" "85.4" "89.7" "137.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3889272514054364250" "False" "High" "IsMasterProtein" "O15541" "E3 ubiquitin-protein ligase RNF113A OS=Homo sapiens OX=9606 GN=RNF113A PE=1 SV=1" "0.000" "False" "9.612" "11" "4" "4" "4" "343" "38.8" "5.69" "6.98" "4" "protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00642, Pf13920" "7737" "ENSG00000125352" "RNF113A" "B2RBR7; hsa:7737; O15541" "" "mRNA Splicing - Major Pathway" "1" "0" "1.160" "1.258" "1.107" "1.155" "1.224" "0.907" "1.396" "1.174" "0.545" "106.2" "123.2" "133.6" "117.6" "122.6" "130.0" "96.3" "148.2" "124.7" "57.8" "" "" "" "" "" "" "" "" "" "" "63.5" "64.0" "74.0" "55.2" "56.8" "66.5" "44.8" "66.5" "67.6" "57.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2502404100025205194" "False" "High" "IsMasterProtein" "P27824" "Calnexin OS=Homo sapiens OX=9606 GN=CANX PE=1 SV=2" "0.000" "False" "9.594" "5" "4" "4" "4" "592" "67.5" "4.60" "8.13" "4" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00262" "821" "ENSG00000127022; ENSG00000283777" "CANX" "B2R5V8; B4DGP8; B4E2T8; D3DWQ3; D6R9K3; hsa:821; P27824" "15q11q13 copy number variation" "MHC class II antigen presentation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Interleukin-35 Signalling; Interleukin-27 signaling; Assembly of Viral Components at the Budding Site; Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "9" "0" "0.867" "0.869" "0.669" "1.040" "0.961" "0.899" "0.765" "1.063" "2.503" "231.4" "200.6" "201.2" "154.9" "240.8" "222.3" "208.0" "177.0" "246.1" "579.2" "" "" "" "" "" "" "" "" "" "" "138.5" "104.2" "111.4" "72.7" "111.6" "113.8" "96.7" "79.5" "133.5" "579.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1811724669038293962" "False" "High" "IsMasterProtein" "Q96RP9" "Elongation factor G, mitochondrial OS=Homo sapiens OX=9606 GN=GFM1 PE=1 SV=2" "0.000" "False" "9.592" "6" "5" "5" "5" "751" "83.4" "7.01" "12.14" "5" "protein metabolism;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "85476" "ENSG00000168827" "GFM1" "A6NCI9; B2RCB9; B3KRW1; hsa:85476; Q6GTN2; Q96RP9; Q96T39" "" "Mitochondrial translation elongation" "1" "0" "1.265" "1.121" "1.323" "1.242" "1.370" "1.163" "0.773" "1.092" "5.934" "77.5" "98.0" "86.9" "102.5" "96.2" "106.1" "90.1" "59.9" "84.6" "459.7" "" "" "" "" "" "" "" "" "" "" "46.4" "50.9" "48.1" "48.1" "44.6" "54.3" "41.9" "26.9" "45.9" "459.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2381350149897154971" "False" "High" "IsMasterProtein" "P51572" "B-cell receptor-associated protein 31 OS=Homo sapiens OX=9606 GN=BCAP31 PE=1 SV=3" "0.000" "False" "9.590" "13" "4" "4" "4" "246" "28.0" "8.44" "9.27" "4" "stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05529, Pf18035" "10134" "ENSG00000185825" "BCAP31" "B3KQ79; D3DWV5; hsa:10134; P51572; Q13836; Q96CF0" "" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC; RSV-host interactions; RHOA GTPase cycle; Apoptotic cleavage of cellular proteins" "5" "0" "1.127" "0.979" "1.013" "1.145" "1.102" "1.148" "1.325" "0.999" "0.488" "227.4" "256.3" "222.7" "230.4" "260.4" "250.6" "261.1" "301.4" "227.3" "111.1" "" "" "" "" "" "" "" "" "" "" "136.1" "133.2" "123.3" "108.2" "120.7" "128.3" "121.4" "135.3" "123.3" "111.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3873794915793825420" "False" "High" "IsMasterProtein" "Q9BYT8" "Neurolysin, mitochondrial OS=Homo sapiens OX=9606 GN=NLN PE=1 SV=1" "0.000" "False" "9.588" "6" "4" "6" "4" "704" "80.6" "6.64" "13.89" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf01432" "57486" "ENSG00000123213" "NLN" "hsa:57486; Q9BYT8; Q9ULJ4" "" "Peptide ligand-binding receptors" "1" "0" "1.046" "1.052" "0.966" "1.111" "0.778" "0.967" "0.973" "0.926" "0.834" "90.9" "95.1" "95.6" "87.8" "101.1" "70.8" "87.9" "88.5" "84.2" "75.8" "" "" "" "" "" "" "" "" "" "" "54.4" "49.4" "53.0" "41.2" "46.8" "36.2" "40.9" "39.7" "45.7" "75.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7476906646827946246" "False" "High" "IsMasterProtein" "Q13315" "Serine-protein kinase ATM OS=Homo sapiens OX=9606 GN=ATM PE=1 SV=4" "0.000" "False" "9.584" "1" "4" "4" "4" "3056" "350.5" "6.81" "7.05" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf11640" "472" "ENSG00000149311" "ATM" "B2RNX5; hsa:472; O15429; Q12758; Q13315; Q16551; Q93007; Q9NP02; Q9UCX7" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Homologous recombination; Glioblastoma signaling pathways; ATM signaling pathway; DDX1 as a regulatory component of the Drosha microprocessor; Ovarian infertility; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; ATM signaling in development and disease ; DNA IR-double strand breaks and cellular response via ATM; miRNA regulation of p53 pathway in prostate cancer; DNA IR-damage and cellular response via ATR; Breast cancer pathway; G1 to S cell cycle control; Joubert syndrome; Male infertility; DNA repair pathways, full network; Pleural mesothelioma; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome; Primary ovarian insufficiency; DNA damage response; DNA damage response (only ATM dependent)" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Autodegradation of the E3 ubiquitin ligase COP1; TP53 Regulates Transcription of DNA Repair Genes; Regulation of HSF1-mediated heat shock response; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Degradation; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of TP53 Activity through Methylation; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Sensing of DNA Double Strand Breaks; Pexophagy" "54" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5309458315612800198" "False" "High" "IsMasterProtein" "O00178" "GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=GTPBP1 PE=1 SV=3" "0.000" "False" "9.578" "6" "3" "3" "3" "669" "72.4" "8.34" "6.72" "3" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144" "9567" "ENSG00000100226" "GTPBP1" "hsa:9567; O00178; Q6IC67" "" "" "0" "0" "1.018" "0.881" "1.268" "1.688" "1.070" "1.505" "0.962" "0.679" "1.815" "18.6" "18.9" "16.4" "23.5" "31.3" "19.9" "27.9" "17.8" "12.6" "33.7" "" "" "" "" "" "" "" "" "" "" "11.1" "9.8" "9.1" "11.0" "14.5" "10.2" "13.0" "8.0" "6.8" "33.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3635452200201599036" "False" "High" "IsMasterProtein" "Q12904" "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Homo sapiens OX=9606 GN=AIMP1 PE=1 SV=2" "0.000" "False" "9.577" "11" "3" "7" "3" "312" "34.3" "8.43" "18.86" "3" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf01588" "9255" "ENSG00000164022" "AIMP1" "B3KTR2; B4E1S7; hsa:9255; Q12904; Q6FG28; Q96CQ9" "Ciliary landscape" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "3" "0" "0.958" "1.011" "1.216" "1.144" "0.966" "1.187" "0.524" "1.026" "4.788" "77.3" "74.0" "78.1" "94.0" "88.4" "74.6" "91.7" "40.5" "79.3" "370.0" "" "" "" "" "" "" "" "" "" "" "46.2" "38.5" "43.3" "44.1" "41.0" "38.2" "42.7" "18.2" "43.0" "370.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "854871700707894946" "False" "High" "IsMasterProtein" "Q9NZL4" "Hsp70-binding protein 1 OS=Homo sapiens OX=9606 GN=HSPBP1 PE=1 SV=2" "0.000" "False" "9.569" "12" "3" "3" "3" "359" "39.3" "5.21" "4.87" "3" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf08609" "23640" "ENSG00000133265" "HSPBP1" "B3KQP0; B4DG11; hsa:23640; O95351; Q6ZNU5; Q9NZL4" "" "" "0" "0" "0.763" "1.286" "1.061" "1.115" "0.829" "0.954" "1.219" "1.171" "3.248" "34.1" "26.0" "43.8" "36.2" "38.0" "28.3" "32.5" "41.6" "39.9" "110.7" "" "" "" "" "" "" "" "" "" "" "20.4" "13.5" "24.3" "17.0" "17.6" "14.5" "15.1" "18.7" "21.7" "110.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4113768837461094803" "False" "High" "IsMasterProtein" "A0AVT1" "Ubiquitin-like modifier-activating enzyme 6 OS=Homo sapiens OX=9606 GN=UBA6 PE=1 SV=1" "0.000" "False" "9.568" "3" "3" "4" "3" "1052" "117.9" "6.14" "11.60" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00899, Pf09358, Pf10585, Pf16190, Pf16191" "55236" "ENSG00000033178" "UBA6" "A0AVT1; A6N8M7; B2RAV3; hsa:55236; Q4W5K0; Q6UV21; Q86T78; Q86TC7; Q8N5T3; Q8N9E4; Q9H3T7; Q9NVC9" "" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "0.879" "0.944" "1.034" "1.249" "1.098" "0.983" "0.462" "0.955" "5.569" "129.1" "113.5" "121.8" "133.4" "161.3" "141.8" "126.9" "59.6" "123.2" "718.8" "" "" "" "" "" "" "" "" "" "" "77.2" "59.0" "67.4" "62.6" "74.8" "72.6" "59.0" "26.8" "66.9" "718.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6660438545085976361" "False" "High" "IsMasterProtein" "Q9BUL5" "PHD finger protein 23 OS=Homo sapiens OX=9606 GN=PHF23 PE=1 SV=1" "0.000" "False" "9.566" "14" "4" "4" "4" "403" "43.8" "5.78" "2.69" "4" "other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13831" "79142" "ENSG00000040633" "PHF23" "A1DZ74; B3KVH8; B4DLK6; D3DTN4; hsa:79142; Q8IZK0; Q96HG7; Q9BUL5; Q9H5X0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6066576864868279087" "False" "High" "IsMasterProtein" "Q9Y263" "Phospholipase A-2-activating protein OS=Homo sapiens OX=9606 GN=PLAA PE=1 SV=2" "0.000" "False" "9.547" "5" "4" "4" "4" "795" "87.1" "6.37" "7.57" "4" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf08324, Pf09070" "9373" "ENSG00000137055" "PLAA" "hsa:9373; Q53EU5; Q5VY33; Q9NUL8; Q9NVE9; Q9UF53; Q9Y263; Q9Y5L1" "" "" "0" "0" "0.933" "1.094" "1.198" "1.438" "1.141" "1.244" "0.928" "1.185" "4.460" "88.6" "82.7" "97.0" "106.2" "127.5" "101.2" "110.3" "82.3" "105.1" "395.3" "" "" "" "" "" "" "" "" "" "" "53.1" "43.0" "53.7" "49.9" "59.1" "51.8" "51.3" "36.9" "57.0" "395.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3559199072785365377" "False" "High" "IsMasterProtein" "Q14493" "Histone RNA hairpin-binding protein OS=Homo sapiens OX=9606 GN=SLBP PE=1 SV=1" "0.000" "False" "9.546" "14" "3" "9" "3" "270" "31.3" "7.47" "18.26" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15247" "7884" "ENSG00000163950" "SLBP" "B3KRJ5; hsa:7884; Q14493" "8p23.1 copy number variation syndrome; 4p16.3 copy number variation" "RNA Polymerase II Transcription Termination; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; Transport of the SLBP Dependant Mature mRNA" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8027894993262294813" "False" "High" "IsMasterProtein" "Q13131" "5'-AMP-activated protein kinase catalytic subunit alpha-1 OS=Homo sapiens OX=9606 GN=PRKAA1 PE=1 SV=4" "0.000" "False" "9.538" "5" "3" "4" "3" "559" "64.0" "8.12" "9.22" "3" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf16579, Pf21147" "5562" "ENSG00000132356" "PRKAA1" "A8MTQ6; B2R7E1; hsa:5562; O00286; Q13131; Q5D0E1; Q86VS1; Q9UNQ4" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Energy metabolism; Thyroxine (thyroid hormone) production; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; mir-124 predicted interactions with cell cycle and differentiation ; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin; Lipid metabolism pathway; PI3K-Akt signaling pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Insulin signaling; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Pleural mesothelioma; Affected pathways in Duchenne muscular dystrophy; ADHD and autism (ASD) linked metabolic pathways and SNP" "Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "36" "0" "1.006" "0.887" "1.148" "1.147" "0.945" "1.002" "0.998" "0.969" "1.441" "151.7" "152.6" "134.6" "174.2" "174.0" "143.4" "152.0" "151.5" "146.9" "218.6" "" "" "" "" "" "" "" "" "" "" "90.8" "79.3" "74.5" "81.8" "80.7" "73.4" "70.7" "68.0" "79.7" "218.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7404612744659791932" "False" "High" "IsMasterProtein" "Q01658" "Protein Dr1 OS=Homo sapiens OX=9606 GN=DR1 PE=1 SV=1" "0.000" "False" "9.533" "16" "3" "3" "3" "176" "19.4" "4.75" "9.93" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "1810" "ENSG00000117505" "DR1" "hsa:1810; Q01658" "" "HATs acetylate histones; Formation of WDR5-containing histone-modifying complexes" "2" "0" "1.103" "0.961" "0.990" "1.033" "1.067" "1.187" "1.056" "1.136" "0.609" "412.3" "454.9" "396.2" "408.2" "425.8" "440.0" "489.2" "435.4" "468.3" "250.9" "" "" "" "" "" "" "" "" "" "" "246.7" "236.4" "219.4" "191.6" "197.4" "225.3" "227.5" "195.5" "254.1" "250.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1058846499056220573" "False" "High" "IsMasterProtein" "Q96CP2" "FLYWCH family member 2 OS=Homo sapiens OX=9606 GN=FLYWCH2 PE=1 SV=1" "0.000" "False" "9.519" "22" "3" "5" "3" "140" "14.6" "8.46" "12.00" "3" "" "" "" "Pf15423" "114984" "ENSG00000162076" "FLYWCH2" "hsa:114984; Q96CP2" "" "" "0" "0" "0.987" "0.985" "1.065" "1.271" "1.015" "1.092" "1.173" "1.010" "0.750" "121.1" "119.6" "119.3" "129.0" "153.9" "122.9" "132.2" "142.1" "122.3" "90.8" "" "" "" "" "" "" "" "" "" "" "72.5" "62.1" "66.1" "60.6" "71.4" "62.9" "61.5" "63.8" "66.4" "90.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9196998486354008360" "False" "High" "IsMasterProtein" "Q6F5E8" "Capping protein, Arp2/3 and myosin-I linker protein 2 OS=Homo sapiens OX=9606 GN=CARMIL2 PE=1 SV=2" "0.000" "False" "9.517" "2" "2" "3" "2" "1435" "154.6" "6.76" "7.96" "2" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13516, Pf16000, Pf17888" "146206" "ENSG00000159753" "CARMIL2" "B8X2Z3; hsa:146206; Q6F5E8" "" "" "0" "0" "1.348" "1.051" "1.078" "0.989" "1.050" "1.460" "0.867" "1.038" "2.794" "36.9" "49.8" "38.8" "39.8" "36.5" "38.8" "53.9" "32.0" "38.3" "103.2" "" "" "" "" "" "" "" "" "" "" "22.1" "25.9" "21.5" "18.7" "16.9" "19.8" "25.1" "14.4" "20.8" "103.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8021819990662325449" "False" "High" "IsMasterProtein" "O43760" "Synaptogyrin-2 OS=Homo sapiens OX=9606 GN=SYNGR2 PE=1 SV=1" "0.000" "False" "9.502" "13" "3" "12" "3" "224" "24.8" "4.94" "30.47" "3" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cell component" "" "Pf01284" "9144" "ENSG00000108639" "SYNGR2" "hsa:9144; O43760; O43762; Q3KQZ2; Q658S7" "" "" "0" "0" "0.976" "0.953" "1.063" "1.061" "1.078" "1.003" "1.063" "0.985" "1.008" "738.2" "720.3" "703.2" "785.0" "783.1" "796.0" "740.5" "784.5" "727.3" "744.1" "" "" "" "" "" "" "" "" "" "" "441.8" "374.3" "389.4" "368.6" "363.0" "407.5" "344.3" "352.2" "394.6" "744.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570011154676120481" "False" "High" "IsMasterProtein" "Q9NRF9" "DNA polymerase epsilon subunit 3 OS=Homo sapiens OX=9606 GN=POLE3 PE=1 SV=1" "0.000" "False" "9.490" "24" "3" "4" "3" "147" "16.8" "4.74" "5.68" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "54107" "ENSG00000148229" "POLE3" "hsa:54107; Q5W0U1; Q8N758; Q8NCE5; Q9NR32; Q9NRF9" "Pyrimidine metabolism; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; Activation of the pre-replicative complex; PCNA-Dependent Long Patch Base Excision Repair; DNA replication initiation" "16" "0" "1.155" "1.038" "0.917" "1.140" "1.096" "0.929" "0.911" "1.013" "1.347" "149.1" "172.1" "154.8" "136.7" "169.9" "163.3" "138.6" "135.8" "151.1" "200.8" "" "" "" "" "" "" "" "" "" "" "89.2" "89.5" "85.7" "64.2" "78.8" "83.6" "64.4" "61.0" "82.0" "200.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4088167174397650062" "False" "High" "IsMasterProtein" "Q9BV20" "Methylthioribose-1-phosphate isomerase OS=Homo sapiens OX=9606 GN=MRI1 PE=1 SV=1" "0.000" "False" "9.487" "8" "3" "3" "3" "369" "39.1" "6.30" "5.86" "3" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01008" "84245" "ENSG00000037757" "MRI1" "hsa:84245; Q8NDC9; Q9BV20" "Methionine de novo and salvage pathway" "Methionine salvage pathway" "2" "0" "1.021" "0.892" "1.165" "0.970" "1.029" "0.967" "1.179" "1.097" "0.634" "118.8" "121.3" "106.0" "138.5" "115.3" "122.3" "114.9" "140.1" "130.4" "75.3" "" "" "" "" "" "" "" "" "" "" "71.1" "63.0" "58.7" "65.0" "53.4" "62.6" "53.4" "62.9" "70.8" "75.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7578805457300167027" "False" "High" "IsMasterProtein" "Q6WKZ4" "Rab11 family-interacting protein 1 OS=Homo sapiens OX=9606 GN=RAB11FIP1 PE=1 SV=3" "0.000" "False" "9.475" "3" "3" "3" "3" "1283" "137.1" "5.43" "7.29" "3" "transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf09457" "80223" "ENSG00000156675" "RAB11FIP1" "hsa:80223; J3KNP0; Q307T1; Q6AZK4; Q6WKZ2; Q6WKZ4; Q6WKZ6; Q86YV4; Q8TDL1; Q9H642" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8204162643568548731" "False" "High" "IsMasterProtein" "Q9HD47" "Ran guanine nucleotide release factor OS=Homo sapiens OX=9606 GN=RANGRF PE=1 SV=1" "0.000" "False" "9.431" "20" "3" "3" "3" "186" "20.4" "4.94" "8.07" "3" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04603" "29098" "ENSG00000108961" "RANGRF" "D3DTR6; hsa:29098; Q68DI3; Q9BR68; Q9HD47; Q9HD48; Q9NRU9; Q9P001; Q9P0P2" "" "Phase 0 - rapid depolarisation" "1" "0" "1.039" "1.051" "1.105" "0.973" "0.964" "0.891" "0.967" "0.952" "0.799" "102.4" "106.3" "107.7" "113.2" "99.7" "98.7" "91.3" "99.0" "97.5" "81.8" "" "" "" "" "" "" "" "" "" "" "61.3" "55.3" "59.6" "53.1" "46.2" "50.5" "42.4" "44.5" "52.9" "81.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5233128446451314475" "False" "High" "IsMasterProtein" "Q8IVD9" "NudC domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NUDCD3 PE=1 SV=3" "0.000" "False" "9.388" "8" "2" "2" "2" "361" "40.8" "5.25" "8.00" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf04969, Pf14050" "23386" "ENSG00000015676" "NUDCD3" "hsa:23386; Q8IVD9; Q9BTI3; Q9H7W9; Q9UPT4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1117159967779804568" "False" "High" "IsMasterProtein" "Q7L4I2" "Arginine/serine-rich coiled-coil protein 2 OS=Homo sapiens OX=9606 GN=RSRC2 PE=1 SV=1" "0.000" "False" "9.387" "8" "3" "3" "3" "434" "50.5" "11.33" "6.54" "3" "" "" "" "Pf15477" "65117" "ENSG00000111011" "RSRC2" "hsa:65117; Q6N040; Q6NW16; Q7L4I2; Q9H864" "" "" "0" "0" "0.847" "1.054" "0.944" "1.196" "1.148" "1.012" "0.925" "1.164" "0.478" "54.5" "46.1" "57.4" "51.4" "65.1" "62.5" "55.1" "50.4" "63.4" "26.0" "" "" "" "" "" "" "" "" "" "" "32.6" "24.0" "31.8" "24.1" "30.2" "32.0" "25.6" "22.6" "34.4" "26.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5802267777781672264" "False" "High" "IsMasterProtein" "O43665" "Regulator of G-protein signaling 10 OS=Homo sapiens OX=9606 GN=RGS10 PE=1 SV=3" "0.000" "False" "9.382" "16" "2" "2" "2" "181" "21.2" "7.49" "7.46" "2" "cell-cell signaling;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00615" "6001" "ENSG00000148908" "RGS10" "A8K408; B1AMR8; hsa:6001; O43665; Q6IAZ6; Q96GN0" "Mesodermal commitment pathway; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "G alpha (i) signalling events" "4" "0" "0.834" "0.829" "1.119" "0.851" "0.883" "0.975" "1.007" "0.939" "0.980" "52.9" "44.1" "43.8" "59.2" "45.0" "46.7" "51.6" "53.2" "49.7" "51.8" "" "" "" "" "" "" "" "" "" "" "31.6" "22.9" "24.3" "27.8" "20.9" "23.9" "24.0" "23.9" "26.9" "51.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "500960934407520232" "False" "High" "IsMasterProtein" "O43716" "Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial OS=Homo sapiens OX=9606 GN=GATC PE=1 SV=1" "0.000" "False" "9.369" "26" "3" "6" "3" "136" "15.1" "5.05" "12.28" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf02686" "283459" "ENSG00000257218" "GATC" "B3KSU7; hsa:283459; O43716; Q3B824; Q3KNR8" "" "" "0" "0" "0.908" "0.916" "1.001" "1.129" "0.864" "1.154" "0.920" "0.839" "1.372" "202.8" "184.1" "185.7" "203.0" "229.0" "175.3" "234.1" "186.5" "170.1" "278.3" "" "" "" "" "" "" "" "" "" "" "121.4" "95.7" "102.8" "95.3" "106.1" "89.7" "108.8" "83.7" "92.3" "278.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3153714913884480543" "False" "High" "IsMasterProtein" "Q8TAE8" "Large ribosomal subunit protein mL64 OS=Homo sapiens OX=9606 GN=GADD45GIP1 PE=1 SV=1" "0.000" "False" "9.348" "14" "2" "2" "2" "222" "25.4" "10.02" "4.28" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf10147" "90480" "ENSG00000179271" "GADD45GIP1" "hsa:90480; Q8IVM3; Q8TAE8; Q8TE51; Q969P9; Q9BSM6" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.281" "1.043" "1.418" "1.162" "1.306" "1.120" "1.331" "1.768" "1.014" "31.6" "40.5" "33.0" "44.8" "36.7" "41.3" "35.4" "42.1" "55.9" "32.0" "" "" "" "" "" "" "" "" "" "" "18.9" "21.0" "18.3" "21.0" "17.0" "21.1" "16.5" "18.9" "30.3" "32.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-652499996560304904" "False" "High" "IsMasterProtein" "P32969" "Large ribosomal subunit protein uL6 OS=Homo sapiens OX=9606 GN=RPL9P9 PE=1 SV=1" "0.000" "False" "9.343" "9" "2" "4" "2" "192" "21.9" "9.95" "10.73" "2" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00347" "6133" "ENSG00000163682" "RPL9; RPL9P7; RPL9P8; RPL9P9" "hsa:6133; P32969" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis" "14" "0" "0.989" "1.102" "0.885" "0.813" "1.035" "0.828" "0.978" "1.013" "0.963" "264.3" "261.3" "291.3" "233.8" "214.9" "273.5" "218.9" "258.4" "267.8" "254.4" "" "" "" "" "" "" "" "" "" "" "158.2" "135.8" "161.3" "109.8" "99.6" "140.0" "101.8" "116.0" "145.3" "254.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400843138587659979" "False" "High" "IsMasterProtein" "P98175" "RNA-binding protein 10 OS=Homo sapiens OX=9606 GN=RBM10 PE=1 SV=3" "0.000" "False" "9.342" "4" "3" "3" "3" "930" "103.5" "5.97" "6.67" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641, Pf01585, Pf17780" "8241" "ENSG00000182872" "RBM10" "A0A0A0MR66; C4AM81; hsa:8241; P98175; Q14136; Q5JRR2; Q9BTE4; Q9BTX0; Q9NTB1" "" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "2" "0" "1.049" "1.110" "1.158" "1.191" "0.936" "1.283" "1.133" "1.106" "1.502" "151.6" "159.0" "168.3" "175.5" "180.5" "141.9" "194.5" "171.7" "167.6" "227.7" "" "" "" "" "" "" "" "" "" "" "90.7" "82.6" "93.2" "82.4" "83.6" "72.7" "90.4" "77.1" "90.9" "227.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7075703887839209806" "False" "High" "IsMasterProtein" "Q14CX7" "N-alpha-acetyltransferase 25, NatB auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA25 PE=1 SV=1" "0.000" "False" "9.324" "4" "4" "5" "4" "972" "112.2" "6.64" "9.49" "4" "" "cytosol;ER/Golgi;other cell component" "" "Pf09797" "80018" "ENSG00000111300" "NAA25" "A0JLU7; hsa:80018; Q14CX7; Q6MZH1; Q7Z4N6; Q9H911" "" "" "0" "0" "1.220" "0.958" "1.067" "1.296" "1.092" "1.110" "0.955" "1.042" "1.944" "154.2" "188.0" "147.6" "164.5" "199.8" "168.3" "171.1" "147.2" "160.6" "299.7" "" "" "" "" "" "" "" "" "" "" "92.3" "97.7" "81.8" "77.2" "92.6" "86.2" "79.6" "66.1" "87.1" "299.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5405439584537602890" "False" "High" "IsMasterProtein" "Q9BX46" "RNA-binding protein 24 OS=Homo sapiens OX=9606 GN=RBM24 PE=1 SV=1" "0.000" "False" "9.324" "15" "3" "7" "3" "236" "24.8" "8.51" "16.47" "3" "RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf00076" "221662" "ENSG00000112183" "RBM24" "E9PAY4; hsa:221662; Q6QDA4; Q8N9D3; Q96NI3; Q9BX46" "" "" "0" "0" "1.049" "1.058" "1.072" "1.046" "1.185" "1.158" "1.201" "1.024" "1.110" "240.1" "252.0" "254.0" "257.4" "251.2" "284.6" "278.1" "288.2" "245.8" "266.4" "" "" "" "" "" "" "" "" "" "" "143.7" "130.9" "140.6" "120.8" "116.4" "145.7" "129.3" "129.4" "133.3" "266.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3178523695898665962" "False" "High" "IsMasterProtein" "Q9NYF8" "Bcl-2-associated transcription factor 1 OS=Homo sapiens OX=9606 GN=BCLAF1 PE=1 SV=2" "0.000" "False" "9.320" "4" "3" "3" "3" "920" "106.1" "9.98" "7.78" "3" "stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15440" "9774" "ENSG00000029363" "BCLAF1" "A2RU75; B7ZM58; E1P586; hsa:9774; Q14673; Q86WU6; Q86WY0; Q9NYF8" "Interactome of polycomb repressive complex 2 (PRC2)" "" "1" "0" "1.033" "1.018" "1.000" "0.906" "0.870" "0.987" "1.192" "1.214" "0.535" "250.0" "258.3" "254.4" "250.1" "226.5" "217.4" "246.7" "298.1" "303.6" "133.7" "" "" "" "" "" "" "" "" "" "" "149.6" "134.2" "140.9" "117.4" "105.0" "111.3" "114.7" "133.8" "164.7" "133.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6333223318553199487" "False" "High" "IsMasterProtein" "Q14919" "Dr1-associated corepressor OS=Homo sapiens OX=9606 GN=DRAP1 PE=1 SV=3" "0.000" "False" "9.319" "10" "2" "8" "2" "205" "22.3" "5.17" "18.22" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00808" "10589" "ENSG00000175550" "DRAP1" "hsa:10589; Q13448; Q14919" "" "Signaling by NODAL; Signaling by Activin" "2" "0" "0.763" "0.883" "0.987" "1.256" "0.934" "1.307" "1.191" "1.219" "0.682" "98.8" "75.4" "87.3" "97.5" "124.1" "92.3" "129.2" "117.7" "120.5" "67.4" "" "" "" "" "" "" "" "" "" "" "59.2" "39.2" "48.4" "45.8" "57.5" "47.3" "60.1" "52.8" "65.4" "67.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6568070672358433938" "False" "High" "IsMasterProtein" "Q00341" "Vigilin OS=Homo sapiens OX=9606 GN=HDLBP PE=1 SV=3" "0.000" "False" "9.316" "3" "4" "5" "4" "1268" "141.4" "6.87" "10.84" "4" "other metabolic processes;transport" "non-structural extracellular;plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "3069" "ENSG00000115677" "HDLBP" "B4DTQ2; E7EM71; hsa:3069; Q00341; Q53QU2; Q9UCY3" "2q37 copy number variation syndrome" "HDL clearance" "2" "0" "1.085" "1.135" "0.864" "1.237" "0.867" "0.731" "0.403" "1.061" "8.009" "30.1" "32.7" "34.2" "26.0" "37.2" "26.1" "22.0" "12.1" "31.9" "241.1" "" "" "" "" "" "" "" "" "" "" "18.0" "17.0" "18.9" "12.2" "17.3" "13.4" "10.2" "5.4" "17.3" "241.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1873273852874603797" "False" "High" "IsMasterProtein" "Q709C8" "Intermembrane lipid transfer protein VPS13C OS=Homo sapiens OX=9606 GN=VPS13C PE=1 SV=1" "0.000" "False" "9.302" "1" "3" "3" "3" "3753" "422.1" "6.83" "6.73" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf06650, Pf09333, Pf12624, Pf16908, Pf16909, Pf16910, Pf21679" "54832" "ENSG00000129003" "VPS13C" "hsa:54832; Q6ISR4; Q702P2; Q702P3; Q709C8; Q709C9; Q9NXN8; Q9P2C6" "" "" "0" "0" "0.978" "0.822" "1.082" "1.169" "1.256" "0.915" "1.225" "1.009" "1.108" "22.7" "22.1" "18.6" "24.5" "26.5" "28.5" "20.7" "27.8" "22.9" "25.1" "" "" "" "" "" "" "" "" "" "" "13.6" "11.5" "10.3" "11.5" "12.3" "14.6" "9.6" "12.5" "12.4" "25.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9028825818345530826" "False" "High" "IsMasterProtein" "Q9UNZ5" "Leydig cell tumor 10 kDa protein homolog OS=Homo sapiens OX=9606 GN=C19orf53 PE=1 SV=1" "0.000" "False" "9.293" "31" "4" "6" "4" "99" "10.6" "11.55" "10.80" "4" "" "" "" "Pf09495" "28974" "ENSG00000104979" "C19orf53" "B2R4J9; hsa:28974; Q9UNZ5" "" "" "0" "0" "1.015" "1.779" "1.766" "1.226" "1.319" "1.063" "1.178" "1.029" "0.327" "22.4" "22.7" "39.8" "39.5" "27.4" "29.5" "23.8" "26.4" "23.0" "7.3" "" "" "" "" "" "" "" "" "" "" "13.4" "11.8" "22.0" "18.6" "12.7" "15.1" "11.1" "11.8" "12.5" "7.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8862135404577219062" "False" "High" "IsMasterProtein" "Q9UJZ1" "Stomatin-like protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=STOML2 PE=1 SV=1" "0.000" "False" "9.293" "13" "3" "3" "3" "356" "38.5" "7.39" "5.79" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion" "signal transduction activity or receptor binding;other molecular function" "Pf01145, Pf16200" "30968" "ENSG00000165283" "STOML2" "B4E1K7; D3DRN3; hsa:30968; O60376; Q53G29; Q96FY2; Q9P042; Q9UJZ1" "" "Processing of SMDT1; Cellular response to mitochondrial stress" "2" "0" "0.811" "0.878" "1.108" "1.106" "0.911" "1.274" "1.004" "1.017" "0.552" "33.3" "27.0" "29.3" "36.9" "36.9" "30.4" "42.5" "33.5" "33.9" "18.4" "" "" "" "" "" "" "" "" "" "" "19.9" "14.0" "16.2" "17.3" "17.1" "15.5" "19.8" "15.0" "18.4" "18.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3343567279109484109" "False" "High" "IsMasterProtein" "P61326" "Protein mago nashi homolog OS=Homo sapiens OX=9606 GN=MAGOH PE=1 SV=1" "0.000" "False" "9.268" "15" "2" "6" "2" "146" "17.2" "6.11" "12.73" "2" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus" "" "Pf02792" "4116" "ENSG00000162385" "MAGOH" "B1ARP8; B2R5A2; hsa:4116; O35169; P50606; P61326; Q5SW69" "TAR syndrome" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "7" "0" "0.969" "1.151" "1.381" "1.044" "1.132" "0.786" "1.191" "1.144" "2.116" "52.7" "51.0" "60.6" "72.7" "55.0" "59.6" "41.4" "62.7" "60.2" "111.4" "" "" "" "" "" "" "" "" "" "" "31.5" "26.5" "33.6" "34.1" "25.5" "30.5" "19.2" "28.1" "32.7" "111.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6665456693960719485" "False" "High" "IsMasterProtein" "Q86V88" "Magnesium-dependent phosphatase 1 OS=Homo sapiens OX=9606 GN=MDP1 PE=1 SV=1" "0.000" "False" "9.255" "13" "2" "4" "2" "176" "20.1" "6.39" "8.26" "2" "" "" "other molecular function" "Pf12689" "145553" "ENSG00000213920; ENSG00000285200" "MDP1" "hsa:145553; Q86V88; Q86Y84; Q8NAD9" "" "" "0" "0" "1.000" "1.009" "1.100" "1.130" "1.038" "1.087" "1.126" "1.138" "0.738" "245.6" "245.6" "247.8" "270.3" "277.6" "255.0" "267.0" "276.5" "279.6" "181.2" "" "" "" "" "" "" "" "" "" "" "147.0" "127.6" "137.2" "126.9" "128.7" "130.6" "124.1" "124.1" "151.7" "181.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8732346175470674622" "False" "High" "IsMasterProtein" "Q86UP2" "Kinectin OS=Homo sapiens OX=9606 GN=KTN1 PE=1 SV=1" "0.000" "False" "9.246" "3" "4" "4" "4" "1357" "156.2" "5.64" "7.33" "4" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi" "cytoskeletal activity" "Pf05104" "3895" "ENSG00000126777" "KTN1" "B4DZ88; hsa:3895; Q13999; Q14707; Q15387; Q17RZ5; Q5GGW3; Q86UP2; Q86W57" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOA GTPase cycle; RND2 GTPase cycle; RND3 GTPase cycle; RHOG GTPase cycle; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; RHO GTPases activate KTN1" "11" "0" "1.186" "0.993" "1.102" "1.097" "1.096" "1.097" "0.865" "1.019" "1.530" "70.7" "83.9" "70.2" "77.9" "77.6" "77.5" "77.6" "61.1" "72.1" "108.2" "" "" "" "" "" "" "" "" "" "" "42.3" "43.6" "38.9" "36.6" "36.0" "39.7" "36.1" "27.5" "39.1" "108.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1866908035804814240" "False" "High" "IsMasterProtein" "P22059" "Oxysterol-binding protein 1 OS=Homo sapiens OX=9606 GN=OSBP PE=1 SV=1" "0.000" "False" "9.237" "4" "2" "3" "2" "807" "89.4" "7.30" "5.89" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "5007" "ENSG00000110048" "OSBP" "hsa:5007; P22059; Q6P524" "" "Sphingolipid de novo biosynthesis; Synthesis of bile acids and bile salts" "2" "0" "0.830" "1.059" "0.890" "1.115" "1.264" "0.943" "0.516" "1.185" "2.907" "25.7" "21.3" "27.2" "22.9" "28.7" "32.5" "24.2" "13.3" "30.5" "74.7" "" "" "" "" "" "" "" "" "" "" "15.4" "11.1" "15.1" "10.7" "13.3" "16.6" "11.3" "6.0" "16.5" "74.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8942814265025091180" "False" "High" "IsMasterProtein" "Q86U28" "Iron-sulfur cluster assembly 2 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=ISCA2 PE=1 SV=2" "0.000" "False" "9.236" "21" "3" "3" "3" "154" "16.5" "5.25" "7.76" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf01521" "122961" "ENSG00000165898" "ISCA2" "A6NFF1; A8K3W3; G3V291; hsa:122961; Q86U28; Q8IYZ0; Q96BB2" "" "Mitochondrial iron-sulfur cluster biogenesis" "1" "0" "0.957" "1.782" "1.469" "1.088" "1.391" "1.324" "1.394" "1.383" "1.743" "22.7" "21.7" "40.5" "33.4" "24.7" "31.6" "30.1" "31.7" "31.4" "39.6" "" "" "" "" "" "" "" "" "" "" "13.6" "11.3" "22.4" "15.7" "11.5" "16.2" "14.0" "14.2" "17.1" "39.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5314014285931232470" "False" "High" "IsMasterProtein" "P18124" "Large ribosomal subunit protein uL30 OS=Homo sapiens OX=9606 GN=RPL7 PE=1 SV=1" "0.000" "False" "9.229" "10" "2" "2" "2" "248" "29.2" "10.65" "6.95" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00327, Pf08079" "6129" "ENSG00000147604" "RPL7" "A8K504; hsa:6129; P18124; Q15289; Q3KQU0; Q5I0X1; Q6IBM9" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.286" "1.349" "0.870" "1.370" "1.129" "1.271" "0.985" "1.141" "0.885" "40.7" "52.3" "54.9" "35.4" "55.7" "45.9" "51.7" "40.1" "46.4" "36.0" "" "" "" "" "" "" "" "" "" "" "24.3" "27.2" "30.4" "16.6" "25.8" "23.5" "24.0" "18.0" "25.2" "36.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2471884395781023228" "False" "High" "IsMasterProtein" "Q9Y5X2" "Sorting nexin-8 OS=Homo sapiens OX=9606 GN=SNX8 PE=1 SV=1" "0.000" "False" "9.221" "6" "3" "6" "3" "465" "52.5" "7.39" "15.23" "3" "transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787, Pf19566" "29886" "ENSG00000106266" "SNX8" "A4D207; hsa:29886; Q96I67; Q9Y5X2" "" "" "0" "0" "0.990" "0.944" "1.010" "1.092" "1.309" "1.162" "1.082" "0.998" "1.074" "352.5" "349.1" "332.8" "356.1" "385.1" "461.4" "409.6" "381.5" "351.8" "378.5" "" "" "" "" "" "" "" "" "" "" "211.0" "181.4" "184.3" "167.2" "178.5" "236.2" "190.5" "171.3" "190.9" "378.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "783704005019212775" "False" "High" "IsMasterProtein" "Q8IZ21" "Phosphatase and actin regulator 4 OS=Homo sapiens OX=9606 GN=PHACTR4 PE=1 SV=1" "0.000" "False" "9.212" "3" "2" "2" "2" "702" "78.2" "6.62" "6.53" "2" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf02755" "65979" "ENSG00000204138" "PHACTR4" "A2APK6; B9ZVW0; D3DPM3; hsa:65979; Q68DD4; Q6NUN6; Q8IZ21; Q8N384; Q9H395; Q9H6X0; Q9H8W6" "" "" "0" "0" "1.173" "1.063" "0.980" "0.980" "0.949" "0.820" "1.216" "1.033" "0.854" "73.2" "85.9" "77.9" "71.7" "71.8" "69.4" "60.0" "89.0" "75.6" "62.5" "" "" "" "" "" "" "" "" "" "" "43.8" "44.6" "43.1" "33.7" "33.3" "35.6" "27.9" "40.0" "41.0" "62.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7745810489150015985" "False" "High" "IsMasterProtein" "O95292" "Vesicle-associated membrane protein-associated protein B/C OS=Homo sapiens OX=9606 GN=VAPB PE=1 SV=3" "0.000" "False" "9.200" "8" "2" "9" "2" "243" "27.2" "7.30" "22.52" "2" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00635" "9217" "ENSG00000124164" "VAPB" "A2A2F2; hsa:9217; O95292; O95293; Q9P0H0" "Ciliary landscape" "RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; Sphingolipid de novo biosynthesis; RAC2 GTPase cycle; RHOD GTPase cycle" "7" "0" "1.060" "0.939" "0.947" "1.128" "1.131" "1.093" "1.065" "1.117" "0.638" "279.2" "296.0" "262.3" "264.6" "315.1" "315.7" "305.1" "297.4" "311.8" "178.1" "" "" "" "" "" "" "" "" "" "" "167.1" "153.8" "145.3" "124.2" "146.0" "161.6" "141.9" "133.5" "169.2" "178.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4039607230823659526" "False" "High" "IsMasterProtein" "P42025" "Beta-centractin OS=Homo sapiens OX=9606 GN=ACTR1B PE=1 SV=1" "0.000" "False" "9.197" "7" "3" "4" "1" "376" "42.3" "6.40" "7.99" "3" "" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00022" "10120" "ENSG00000115073; ENSG00000291597" "ACTR1B" "D3DVH2; hsa:10120; P42025; Q53SK5; Q9BRB7" "" "MHC class II antigen presentation; Neutrophil degranulation" "2" "0" "1.349" "1.235" "1.103" "1.183" "1.446" "0.944" "1.186" "1.415" "0.980" "50.2" "67.8" "62.1" "55.4" "59.5" "72.7" "47.4" "59.6" "71.1" "49.2" "" "" "" "" "" "" "" "" "" "" "30.1" "35.2" "34.4" "26.0" "27.6" "37.2" "22.0" "26.7" "38.6" "49.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4607454407969117171" "False" "High" "IsMasterProtein" "A6NED2" "RCC1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCCD1 PE=1 SV=1" "0.000" "False" "9.184" "7" "2" "2" "2" "376" "40.1" "5.27" "6.73" "2" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf00415" "91433" "ENSG00000166965" "RCCD1" "A6NED2; B2RTP9; hsa:91433; Q29RX6" "" "Protein hydroxylation" "1" "0" "1.168" "0.984" "1.491" "1.239" "0.946" "1.431" "1.367" "1.078" "0.869" "65.1" "76.0" "64.0" "97.0" "80.6" "61.6" "93.1" "88.9" "70.2" "56.6" "" "" "" "" "" "" "" "" "" "" "38.9" "39.5" "35.5" "45.5" "37.4" "31.5" "43.3" "39.9" "38.1" "56.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7165899401853608207" "False" "High" "IsMasterProtein" "P04424" "Argininosuccinate lyase OS=Homo sapiens OX=9606 GN=ASL PE=1 SV=4" "0.000" "False" "9.175" "6" "3" "4" "3" "464" "51.6" "6.48" "9.66" "3" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00206, Pf14698" "435" "ENSG00000126522" "ASL" "E7EMI0; E9PE48; hsa:435; P04424; Q6LDS5; Q96HS2" "Alanine and aspartate metabolism" "Urea cycle" "2" "0" "1.131" "1.049" "1.310" "0.968" "0.834" "0.856" "1.078" "0.788" "0.689" "308.5" "349.1" "323.7" "404.2" "298.6" "257.3" "264.2" "332.5" "243.1" "212.6" "" "" "" "" "" "" "" "" "" "" "184.6" "181.4" "179.2" "189.8" "138.4" "131.7" "122.8" "149.3" "131.9" "212.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5615919369887998349" "False" "High" "IsMasterProtein" "P49903" "Selenide, water dikinase 1 OS=Homo sapiens OX=9606 GN=SEPHS1 PE=1 SV=2" "0.000" "False" "9.156" "13" "4" "4" "3" "392" "42.9" "5.97" "5.32" "4" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf00586, Pf02769" "22929" "ENSG00000086475" "SEPHS1" "B4DWK0; D3DRS9; D6PSQ9; hsa:22929; P49903; Q5T5U8; Q5T5U9; Q9BVT4" "" "" "0" "1" "0.832" "0.952" "0.750" "0.769" "0.696" "0.900" "0.764" "0.901" "0.260" "242.3" "201.6" "230.8" "181.8" "186.4" "168.5" "217.9" "185.0" "218.2" "63.0" "" "" "" "" "" "" "" "" "" "" "145.0" "104.8" "127.8" "85.4" "86.4" "86.3" "101.3" "83.1" "118.4" "63.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7391762605629829309" "False" "High" "IsMasterProtein" "O95801" "Tetratricopeptide repeat protein 4 OS=Homo sapiens OX=9606 GN=TTC4 PE=1 SV=3" "0.000" "False" "9.149" "7" "3" "3" "3" "387" "44.7" "5.60" "7.33" "3" "protein metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf18972" "7268" "ENSG00000243725" "TTC4" "hsa:7268; O95801; Q53Y95; Q5TA96; Q9H3I2" "" "" "0" "0" "1.401" "1.385" "1.349" "1.350" "1.252" "1.292" "0.651" "1.225" "5.637" "59.5" "83.3" "82.4" "80.2" "80.3" "74.5" "76.9" "38.7" "72.9" "335.3" "" "" "" "" "" "" "" "" "" "" "35.6" "43.3" "45.6" "37.7" "37.2" "38.1" "35.7" "17.4" "39.5" "335.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2383613337026514959" "False" "High" "IsMasterProtein" "Q93052" "Lipoma-preferred partner OS=Homo sapiens OX=9606 GN=LPP PE=1 SV=1" "0.000" "False" "9.130" "4" "2" "3" "2" "612" "65.7" "7.37" "8.86" "2" "cell adhesion" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "4026" "ENSG00000145012" "LPP" "A1L4L6; D3DNV6; hsa:4026; Q8NFX5; Q93052" "MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement" "" "1" "0" "0.984" "0.982" "1.056" "1.323" "1.166" "1.056" "0.936" "1.011" "1.167" "80.1" "78.8" "78.7" "84.6" "106.0" "93.4" "84.6" "75.0" "81.0" "93.5" "" "" "" "" "" "" "" "" "" "" "47.9" "40.9" "43.6" "39.7" "49.1" "47.8" "39.3" "33.7" "44.0" "93.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5348588292702008792" "False" "High" "IsMasterProtein" "O94888" "UBX domain-containing protein 7 OS=Homo sapiens OX=9606 GN=UBXN7 PE=1 SV=2" "0.000" "False" "9.120" "5" "2" "6" "2" "489" "54.8" "5.16" "15.48" "2" "protein metabolism;other metabolic processes" "other membranes;cytosol;ER/Golgi;nucleus" "other molecular function" "Pf00789, Pf13899, Pf14555" "26043" "ENSG00000163960" "UBXN7" "D3DXB3; hsa:26043; O94888; Q6ZP77; Q86X20; Q8N327" "3q29 copy number variation syndrome" "Neddylation; KEAP1-NFE2L2 pathway" "3" "0" "1.167" "1.016" "0.956" "1.118" "0.912" "0.910" "0.878" "0.865" "1.157" "115.8" "135.1" "117.6" "110.6" "129.4" "105.6" "105.4" "101.7" "100.1" "133.9" "" "" "" "" "" "" "" "" "" "" "69.3" "70.2" "65.1" "51.9" "60.0" "54.1" "49.0" "45.7" "54.3" "133.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1698483045954744258" "False" "High" "IsMasterProtein" "Q15018" "BRISC complex subunit Abraxas 2 OS=Homo sapiens OX=9606 GN=ABRAXAS2 PE=1 SV=2" "0.000" "False" "9.114" "10" "4" "7" "4" "415" "46.9" "6.21" "14.30" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf21125" "23172" "ENSG00000165660" "ABRAXAS2" "B4DKR2; hsa:23172; Q15018; Q96H11" "" "Metalloprotease DUBs" "1" "0" "1.034" "0.985" "1.048" "1.050" "0.984" "0.997" "0.940" "0.987" "0.746" "584.4" "604.5" "575.5" "612.3" "613.5" "574.9" "582.8" "549.6" "576.7" "436.1" "" "" "" "" "" "" "" "" "" "" "349.7" "314.2" "318.7" "287.4" "284.4" "294.3" "271.0" "246.7" "312.9" "436.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7927368921331951811" "False" "High" "IsMasterProtein" "Cont_O46375" "Transthyretin OS=Bos taurus OX=9913 GN=TTR PE=1 SV=1" "0.000" "True" "9.114" "24" "3" "7" "3" "147" "15.7" "6.30" "19.58" "3" "other metabolic processes;signal transduction" "non-structural extracellular" "signal transduction activity or receptor binding;other molecular function" "Pf00576" "102267525; 104980319; 109577967; 280948" "ENSBGRG00000022634; ENSBIXG00000008920; ENSBIXG00005017301; ENSBTAG00000010991" "TTR" "A0A4W2BU20; A0A6B0QTW8; A0A6P3GKP7; A0A6P5DX06; A0A8B9YDR1; bbis:104980319; biu:109577967; bom:102267525; bta:280948; O46375; Q3SZ91" "" "Neutrophil degranulation; Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision)" "3" "0" "1.190" "1.192" "1.035" "0.850" "1.025" "1.118" "1.162" "1.231" "0.586" "383.4" "456.4" "457.1" "397.0" "326.0" "392.9" "428.5" "445.4" "471.9" "224.5" "" "" "" "" "" "" "" "" "" "" "229.4" "237.2" "253.1" "186.4" "151.1" "201.1" "199.2" "200.0" "256.1" "224.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-493599392499449744" "False" "High" "IsMasterProtein" "P53990" "IST1 homolog OS=Homo sapiens OX=9606 GN=IST1 PE=1 SV=1" "0.000" "False" "9.107" "7" "3" "4" "3" "364" "39.7" "5.35" "10.55" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03398" "9798" "ENSG00000182149" "IST1" "A8KAH5; hsa:9798; J3QLU7; P53990; Q3SYM4; Q9BQ81; Q9BWN2" "" "Neutrophil degranulation; Sealing of the nuclear envelope (NE) by ESCRT-III" "2" "0" "1.101" "1.212" "1.169" "1.075" "1.087" "1.284" "0.871" "1.212" "3.834" "89.0" "98.0" "107.8" "104.0" "95.7" "96.7" "114.2" "77.5" "107.9" "341.2" "" "" "" "" "" "" "" "" "" "" "53.3" "50.9" "59.7" "48.8" "44.3" "49.5" "53.1" "34.8" "58.5" "341.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-547053484993874983" "False" "High" "IsMasterProtein" "Q13085" "Acetyl-CoA carboxylase 1 OS=Homo sapiens OX=9606 GN=ACACA PE=1 SV=2" "0.000" "False" "9.100" "1" "3" "3" "3" "2346" "265.4" "6.37" "8.17" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus" "other molecular function" "Pf00289, Pf00364, Pf01039, Pf02785, Pf02786, Pf08326, Pf21385" "31" "ENSG00000275176; ENSG00000278540" "ACACA" "B2RP68; B2ZZ90; hsa:31; Q13085; Q6KEV6; Q6XDA8; Q7Z2G8; Q7Z561; Q7Z563; Q7Z564; Q86WB2; Q86WB3" "AMP-activated protein kinase signaling; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Hereditary leiomyomatosis and renal cell carcinoma pathway; Mitochondrial fatty acid synthesis pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; 7q11.23 copy number variation syndrome; 17q12 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; ADHD and autism (ASD) linked metabolic pathways and SNP" "ChREBP activates metabolic gene expression; Biotin transport and metabolism; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; Defective HLCS causes multiple carboxylase deficiency" "24" "0" "1.228" "1.036" "1.513" "1.477" "1.177" "1.132" "0.942" "1.723" "2.310" "29.8" "36.6" "30.9" "45.0" "44.0" "35.0" "33.7" "28.1" "51.3" "68.8" "" "" "" "" "" "" "" "" "" "" "17.8" "19.0" "17.1" "21.1" "20.4" "17.9" "15.7" "12.6" "27.8" "68.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5925761923209875400" "False" "High" "IsMasterProtein" "Q12824" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Homo sapiens OX=9606 GN=SMARCB1 PE=1 SV=2" "0.000" "False" "9.075" "8" "2" "2" "2" "385" "44.1" "6.23" "7.36" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04855, Pf21459" "6598" "ENSG00000099956; ENSG00000275837" "SMARCB1" "hsa:6598; O75784; O95474; Q12824; Q17S11; Q38GA1; Q76N08; Q9UBH2" "Tumor suppressor activity of SMARCB1; Thermogenesis; Modulators of TCR signaling and T cell activation; DYRK1A involvement regarding cell proliferation in brain development; Kleefstra syndrome; 10q11.21q11.23 copy number variation syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "8" "0" "1.033" "0.934" "1.350" "1.268" "0.820" "1.411" "0.010" "0.849" "8.325" "16.9" "17.4" "15.8" "22.8" "21.4" "13.8" "23.8" "0.0" "14.3" "140.5" "" "" "" "" "" "" "" "" "" "" "10.1" "9.1" "8.7" "10.7" "9.9" "7.1" "11.1" "0.0" "7.8" "140.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "779708130048871486" "False" "High" "IsMasterProtein" "O43464" "Serine protease HTRA2, mitochondrial OS=Homo sapiens OX=9606 GN=HTRA2 PE=1 SV=2" "0.000" "False" "9.068" "7" "3" "5" "3" "458" "48.8" "10.07" "13.15" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf13365, Pf17820" "27429" "ENSG00000115317" "HTRA2" "hsa:27429; O43464; Q9HBZ4; Q9P0Y3; Q9P0Y4" "Apoptosis modulation and signaling; Parkinson's disease pathway; Nanomaterial induced apoptosis; Ciliary landscape; Complement system in neuronal development and plasticity" "Mitochondrial protein degradation" "6" "0" "1.078" "1.075" "1.109" "0.983" "1.129" "0.959" "1.247" "1.101" "0.701" "136.1" "146.8" "146.3" "151.0" "133.9" "153.7" "130.6" "169.8" "149.9" "95.4" "" "" "" "" "" "" "" "" "" "" "81.5" "76.3" "81.0" "70.9" "62.0" "78.7" "60.7" "76.2" "81.4" "95.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5100210059596347713" "False" "High" "IsMasterProtein" "P04899" "Guanine nucleotide-binding protein G(i) subunit alpha-2 OS=Homo sapiens OX=9606 GN=GNAI2 PE=1 SV=3" "0.000" "False" "9.066" "11" "3" "3" "2" "355" "40.4" "5.54" "6.06" "3" "cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00503" "2771" "ENSG00000114353" "GNAI2" "B3KTZ0; B4DYA0; B4E2X5; hsa:2771; P04899; Q6B6N3; Q8IZ71" "Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; S1P receptor signal transduction; Complement system; G protein signaling pathways; Chemokine signaling pathway; Hippo signaling regulation pathways; Purinergic signaling; Opioid receptor pathways; Calcium regulation in cardiac cells; 5q35 copy number variation; Serotonin HTR1 group and FOS pathway" "G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Adrenaline,noradrenaline inhibits insulin secretion" "22" "0" "1.239" "1.001" "1.363" "1.078" "0.925" "1.265" "0.991" "1.240" "1.525" "39.6" "49.1" "39.6" "54.0" "42.7" "36.6" "50.1" "39.2" "49.1" "60.4" "" "" "" "" "" "" "" "" "" "" "23.7" "25.5" "21.9" "25.3" "19.8" "18.8" "23.3" "17.6" "26.6" "60.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5658103532290025162" "False" "High" "IsMasterProtein" "P49770" "Translation initiation factor eIF2B subunit beta OS=Homo sapiens OX=9606 GN=EIF2B2 PE=1 SV=3" "0.000" "False" "9.039" "10" "3" "4" "3" "351" "39.0" "6.16" "8.09" "3" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "8892" "ENSG00000119718" "EIF2B2" "hsa:8892; O43201; P49770" "Translation factors; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Rett syndrome; Primary ovarian insufficiency" "Recycling of eIF2:GDP" "5" "0" "0.973" "0.989" "1.291" "1.310" "1.337" "1.135" "1.228" "1.207" "1.173" "78.2" "76.1" "77.4" "101.0" "102.5" "104.6" "88.8" "96.1" "94.4" "91.8" "" "" "" "" "" "" "" "" "" "" "46.8" "39.6" "42.8" "47.4" "47.5" "53.6" "41.3" "43.1" "51.2" "91.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6971851119340033318" "False" "High" "IsMasterProtein" "Q712K3" "Ubiquitin-conjugating enzyme E2 R2 OS=Homo sapiens OX=9606 GN=UBE2R2 PE=1 SV=1" "0.000" "False" "9.024" "11" "3" "3" "3" "238" "27.1" "4.42" "8.66" "3" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00179" "54926" "ENSG00000107341" "UBE2R2" "D3DRL5; hsa:54926; Q712K3; Q9NX64" "" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "2" "0" "1.151" "1.100" "1.240" "1.180" "1.109" "1.211" "1.054" "1.115" "1.240" "299.9" "345.1" "329.9" "372.0" "353.9" "332.6" "363.3" "316.1" "334.5" "372.0" "" "" "" "" "" "" "" "" "" "" "179.5" "179.3" "182.7" "174.6" "164.1" "170.3" "168.9" "141.9" "181.5" "372.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7569413463716614588" "False" "High" "IsMasterProtein" "Q8N6M0" "Deubiquitinase OTUD6B OS=Homo sapiens OX=9606 GN=OTUD6B PE=1 SV=1" "0.000" "False" "9.023" "10" "3" "3" "3" "293" "33.8" "6.05" "7.91" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf02338" "51633" "ENSG00000155100" "OTUD6B" "A8K6I1; B4DEY0; hsa:51633; Q8N6M0; Q9NTA4; Q9Y387" "Warburg effect modulated by deubiquitinating enzymes and their substrates" "" "1" "0" "1.222" "1.510" "1.314" "1.675" "1.481" "1.585" "0.820" "1.260" "2.198" "18.3" "22.4" "27.6" "24.0" "30.6" "27.1" "29.0" "15.0" "23.0" "40.2" "" "" "" "" "" "" "" "" "" "" "10.9" "11.6" "15.3" "11.3" "14.2" "13.9" "13.5" "6.7" "12.5" "40.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5181742408378363027" "False" "High" "IsMasterProtein" "P62253" "Ubiquitin-conjugating enzyme E2 G1 OS=Homo sapiens OX=9606 GN=UBE2G1 PE=1 SV=3" "0.000" "False" "9.018" "20" "4" "5" "4" "170" "19.5" "5.30" "8.61" "4" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00179" "7326" "ENSG00000132388" "UBE2G1" "B2R7P2; D3DTK0; hsa:7326; P62253; Q99462" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "4" "0" "1.210" "1.098" "1.110" "1.308" "1.218" "1.274" "1.200" "1.174" "1.032" "279.2" "337.8" "306.4" "310.0" "365.3" "340.0" "355.6" "335.1" "327.8" "288.1" "" "" "" "" "" "" "" "" "" "" "167.1" "175.5" "169.7" "145.5" "169.3" "174.1" "165.4" "150.4" "177.8" "288.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2064398730154585057" "False" "High" "IsMasterProtein" "Q15061" "WD repeat-containing protein 43 OS=Homo sapiens OX=9606 GN=WDR43 PE=1 SV=3" "0.000" "False" "9.000" "5" "4" "5" "4" "677" "74.8" "5.57" "6.04" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf04003" "23160" "ENSG00000163811" "WDR43" "hsa:23160; Q15061; Q15395; Q92577" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.720" "1.004" "1.390" "1.116" "1.447" "1.507" "1.279" "1.117" "0.995" "57.0" "98.0" "57.2" "79.2" "63.6" "82.5" "85.9" "72.9" "63.7" "56.7" "" "" "" "" "" "" "" "" "" "" "34.1" "51.0" "31.7" "37.2" "29.5" "42.2" "39.9" "32.7" "34.5" "56.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3854455294821174963" "False" "High" "IsMasterProtein" "Q969X6" "U3 small nucleolar RNA-associated protein 4 homolog OS=Homo sapiens OX=9606 GN=UTP4 PE=1 SV=1" "0.000" "False" "8.984" "6" "4" "5" "4" "686" "76.8" "8.85" "6.72" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "84916" "ENSG00000141076; ENSG00000262788" "UTP4" "hsa:84916; Q8NCD9; Q8TF14; Q969X6; Q96SP0; Q96SR9; Q96SZ9; Q96T13; Q9BWK6" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.772" "0.898" "0.909" "1.180" "1.088" "1.129" "0.809" "0.892" "0.772" "59.4" "45.8" "53.3" "54.0" "70.1" "64.6" "67.0" "48.0" "53.0" "45.8" "" "" "" "" "" "" "" "" "" "" "35.5" "23.8" "29.5" "25.3" "32.5" "33.1" "31.2" "21.6" "28.7" "45.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "275596885495269995" "False" "High" "IsMasterProtein" "Q14166" "Tubulin--tyrosine ligase-like protein 12 OS=Homo sapiens OX=9606 GN=TTLL12 PE=1 SV=2" "0.000" "False" "8.976" "5" "3" "3" "3" "644" "74.4" "5.53" "7.88" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03133" "23170" "ENSG00000100304" "TTLL12" "hsa:23170; Q14166; Q20WK5; Q9UGU3" "" "Carboxyterminal post-translational modifications of tubulin" "1" "0" "1.213" "1.413" "1.631" "1.777" "1.244" "1.914" "0.914" "1.508" "10.777" "17.4" "21.1" "24.6" "28.4" "30.9" "21.6" "33.3" "15.9" "26.2" "187.5" "" "" "" "" "" "" "" "" "" "" "10.4" "11.0" "13.6" "13.3" "14.3" "11.1" "15.5" "7.1" "14.2" "187.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4571084566871798353" "False" "High" "IsMasterProtein" "Q9Y2S6" "Translation machinery-associated protein 7 OS=Homo sapiens OX=9606 GN=TMA7 PE=1 SV=1" "0.000" "False" "8.975" "23" "2" "14" "1" "64" "7.1" "9.99" "43.87" "2" "" "" "" "Pf09072" "51372" "ENSG00000232112" "TMA7" "hsa:51372; Q9P052; Q9Y2S6" "" "" "0" "0" "0.993" "1.029" "1.009" "1.049" "1.070" "1.028" "1.248" "0.968" "0.446" "1802.4" "1789.8" "1855.5" "1818.2" "1891.3" "1928.0" "1852.8" "2250.1" "1745.2" "803.8" "" "" "" "" "" "" "" "" "" "" "1078.6" "930.1" "1027.5" "853.6" "876.7" "987.0" "861.5" "1010.2" "946.8" "803.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4746768512254432328" "False" "High" "IsMasterProtein" "Q9Y4X5" "E3 ubiquitin-protein ligase ARIH1 OS=Homo sapiens OX=9606 GN=ARIH1 PE=1 SV=2" "0.000" "False" "8.937" "6" "3" "3" "3" "557" "64.1" "5.08" "7.86" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097, Pf01485, Pf19422, Pf21235" "25820" "ENSG00000166233" "ARIH1" "B2R6U3; hsa:25820; O76026; Q9H3T6; Q9UEN0; Q9UP39; Q9Y4X5" "" "PKR-mediated signaling; ISG15 antiviral mechanism; RSV-host interactions" "3" "0" "0.911" "1.038" "0.996" "1.042" "0.935" "1.130" "1.159" "0.984" "0.730" "93.6" "85.3" "97.2" "93.3" "97.5" "87.6" "105.8" "108.5" "92.2" "68.3" "" "" "" "" "" "" "" "" "" "" "56.0" "44.4" "53.8" "43.8" "45.2" "44.8" "49.2" "48.7" "50.0" "68.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1492167490634941437" "False" "High" "IsMasterProtein" "P49914" "5-formyltetrahydrofolate cyclo-ligase OS=Homo sapiens OX=9606 GN=MTHFS PE=1 SV=2" "0.000" "False" "8.934" "15" "3" "4" "3" "203" "23.2" "7.88" "7.38" "3" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01812" "10588" "ENSG00000136371" "MTHFS" "H3BQ75; hsa:10588; P49914" "Folate metabolism; One-carbon metabolism; Disorders of folate metabolism and transport" "Metabolism of folate and pterines" "4" "0" "1.088" "1.111" "1.211" "1.172" "1.343" "1.177" "1.183" "1.163" "1.943" "93.8" "102.0" "104.2" "113.5" "109.9" "126.0" "110.3" "111.0" "109.1" "182.2" "" "" "" "" "" "" "" "" "" "" "56.1" "53.0" "57.7" "53.3" "51.0" "64.5" "51.3" "49.8" "59.2" "182.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8979611846707191829" "False" "High" "IsMasterProtein" "O76080" "AN1-type zinc finger protein 5 OS=Homo sapiens OX=9606 GN=ZFAND5 PE=1 SV=1" "0.000" "False" "8.903" "23" "3" "4" "3" "213" "23.1" "8.51" "4.92" "3" "developmental processes;signal transduction;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf01428, Pf01754" "7763" "ENSG00000107372" "ZFAND5" "A8K484; hsa:7763; O76080" "" "" "0" "0" "0.877" "0.852" "0.731" "1.001" "0.817" "1.015" "0.861" "0.945" "0.736" "113.4" "99.5" "96.6" "82.9" "113.5" "92.7" "115.1" "97.6" "107.2" "83.5" "" "" "" "" "" "" "" "" "" "" "67.9" "51.7" "53.5" "38.9" "52.6" "47.5" "53.5" "43.8" "58.2" "83.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7082716862048425116" "False" "High" "IsMasterProtein" "Q9BPX3" "Condensin complex subunit 3 OS=Homo sapiens OX=9606 GN=NCAPG PE=1 SV=1" "0.000" "False" "8.899" "3" "4" "4" "4" "1015" "114.3" "5.59" "7.88" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "Pf12719" "64151" "ENSG00000109805" "NCAPG" "hsa:64151; Q3MJE0; Q96SV9; Q9BPX3; Q9BUR3; Q9BVY1; Q9H914; Q9H9Z6; Q9HBI9" "" "Condensation of Prometaphase Chromosomes" "1" "0" "0.934" "1.048" "1.027" "1.469" "2.100" "1.516" "0.241" "1.556" "12.444" "13.5" "12.6" "14.1" "13.9" "19.8" "28.3" "20.5" "3.2" "21.0" "167.9" "" "" "" "" "" "" "" "" "" "" "8.1" "6.5" "7.8" "6.5" "9.2" "14.5" "9.5" "1.5" "11.4" "167.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5814198643835656164" "False" "High" "IsMasterProtein" "O60711" "Leupaxin OS=Homo sapiens OX=9606 GN=LPXN PE=1 SV=1" "0.000" "False" "8.899" "10" "4" "5" "4" "386" "43.3" "6.01" "8.20" "4" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "9404" "ENSG00000110031" "LPXN" "B2R8B4; B4DV71; hsa:9404; O60711; Q53FW6; Q6FI07" "" "" "0" "0" "1.039" "1.225" "1.131" "1.358" "0.900" "1.493" "1.017" "1.171" "2.447" "87.8" "91.2" "107.6" "99.4" "119.3" "79.0" "131.1" "89.3" "102.9" "214.9" "" "" "" "" "" "" "" "" "" "" "52.6" "47.4" "59.6" "46.7" "55.3" "40.5" "61.0" "40.1" "55.8" "214.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9167076474534668157" "False" "High" "IsMasterProtein" "Q15398" "Disks large-associated protein 5 OS=Homo sapiens OX=9606 GN=DLGAP5 PE=1 SV=2" "0.000" "False" "8.887" "3" "3" "3" "3" "846" "95.1" "9.00" "5.44" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf03359" "9787" "ENSG00000126787" "DLGAP5" "A8MTM6; B4DRM8; hsa:9787; Q15398; Q86T11; Q8NG58" "Complement system in neuronal development and plasticity" "NOTCH3 Intracellular Domain Regulates Transcription" "2" "0" "0.859" "0.956" "0.971" "0.840" "0.812" "1.152" "0.885" "0.864" "3.533" "60.8" "52.2" "58.1" "59.0" "51.0" "49.3" "70.0" "53.8" "52.5" "214.8" "" "" "" "" "" "" "" "" "" "" "36.4" "27.1" "32.2" "27.7" "23.7" "25.3" "32.6" "24.1" "28.5" "214.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824521577804774203" "False" "High" "IsMasterProtein" "Q53GS9" "Ubiquitin carboxyl-terminal hydrolase 39 OS=Homo sapiens OX=9606 GN=USP39 PE=1 SV=2" "0.000" "False" "8.879" "5" "3" "3" "3" "565" "65.3" "8.91" "4.89" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00443, Pf02148" "10713" "ENSG00000168883" "USP39" "A8K086; B3KM40; B4DHT4; D6W5L4; G5E9H0; hsa:10713; Q53GS9; Q6NX47; Q96RK9; Q9BV89; Q9H381; Q9P050; Q9Y310" "" "mRNA Splicing - Major Pathway" "1" "0" "1.319" "0.930" "1.015" "0.928" "1.189" "0.944" "0.769" "0.926" "1.147" "23.9" "31.5" "22.2" "24.3" "22.2" "28.4" "22.6" "18.4" "22.1" "27.4" "" "" "" "" "" "" "" "" "" "" "14.3" "16.4" "12.3" "11.4" "10.3" "14.6" "10.5" "8.3" "12.0" "27.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3397920079809031089" "False" "High" "IsMasterProtein" "Q7Z5R6" "Amyloid beta A4 precursor protein-binding family B member 1-interacting protein OS=Homo sapiens OX=9606 GN=APBB1IP PE=1 SV=1" "0.000" "False" "8.869" "5" "3" "3" "3" "666" "73.1" "5.59" "5.28" "3" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "" "Pf00169, Pf00788" "54518" "ENSG00000077420" "APBB1IP" "hsa:54518; Q7Z5R6; Q8IWS8; Q8IYL7; Q8IZZ7" "TYROBP causal network in microglia" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins" "11" "0" "0.953" "0.871" "0.935" "0.999" "1.236" "1.021" "1.018" "0.951" "1.487" "78.2" "74.5" "68.1" "73.1" "78.1" "96.6" "79.8" "79.6" "74.3" "116.3" "" "" "" "" "" "" "" "" "" "" "46.8" "38.7" "37.7" "34.3" "36.2" "49.5" "37.1" "35.7" "40.3" "116.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "124053754926249858" "False" "High" "IsMasterProtein" "Q9UBF2" "Coatomer subunit gamma-2 OS=Homo sapiens OX=9606 GN=COPG2 PE=1 SV=1" "0.000" "False" "8.862" "3" "3" "3" "2" "871" "97.6" "5.81" "5.92" "3" "transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01602, Pf08752, Pf16381" "26958" "ENSG00000158623" "COPG2" "A6NH74; hsa:26958; Q2NLA0; Q54AC3; Q8WVW8; Q9UBF2" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "1.051" "1.142" "1.112" "1.066" "1.305" "1.118" "1.057" "1.162" "1.825" "102.6" "107.8" "117.1" "114.1" "109.4" "133.9" "114.6" "108.5" "119.2" "187.2" "" "" "" "" "" "" "" "" "" "" "61.4" "56.0" "64.9" "53.6" "50.7" "68.5" "53.3" "48.7" "64.7" "187.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5965244756027354747" "False" "High" "IsMasterProtein" "O75414" "Nucleoside diphosphate kinase 6 OS=Homo sapiens OX=9606 GN=NME6 PE=1 SV=3" "0.000" "False" "8.845" "19" "3" "3" "3" "186" "21.1" "8.32" "7.19" "3" "other metabolic processes;other biological processes" "mitochondrion" "kinase activity;other molecular function" "Pf00334" "10201" "ENSG00000172113" "NME6" "B4DGW7; B4DM99; hsa:10201; O75414; Q53HM5; Q96E73; Q9BQ63" "Pyrimidine metabolism" "" "1" "0" "1.004" "0.953" "1.073" "0.965" "1.032" "0.949" "1.014" "0.967" "0.662" "183.1" "183.8" "174.4" "196.3" "176.6" "189.0" "173.7" "185.7" "177.1" "121.1" "" "" "" "" "" "" "" "" "" "" "109.5" "95.5" "96.6" "92.2" "81.9" "96.8" "80.8" "83.4" "96.1" "121.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4493401864324206702" "False" "High" "IsMasterProtein" "Q53S33" "BolA-like protein 3 OS=Homo sapiens OX=9606 GN=BOLA3 PE=1 SV=1" "0.000" "False" "8.828" "25" "3" "7" "3" "107" "12.1" "9.64" "18.69" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "" "Pf01722" "388962" "ENSG00000163170" "BOLA3" "G3XAB0; hsa:388962; Q53S33" "" "" "0" "0" "0.988" "0.952" "1.008" "1.074" "0.980" "1.096" "1.075" "0.930" "0.681" "622.8" "615.1" "592.9" "627.8" "668.8" "610.2" "682.4" "669.7" "579.0" "424.3" "" "" "" "" "" "" "" "" "" "" "372.7" "319.7" "328.3" "294.8" "310.0" "312.4" "317.3" "300.7" "314.1" "424.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5929165091375925329" "False" "High" "IsMasterProtein" "Q15545" "Transcription initiation factor TFIID subunit 7 OS=Homo sapiens OX=9606 GN=TAF7 PE=1 SV=1" "0.000" "False" "8.821" "9" "2" "2" "2" "349" "40.2" "5.20" "3.95" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04658" "6879" "ENSG00000178913" "TAF7" "B2RBV9; hsa:6879; Q13036; Q15545" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6012550924560015135" "False" "High" "IsMasterProtein" "O43805" "Microtubule nucleation factor SSNA1 OS=Homo sapiens OX=9606 GN=SSNA1 PE=1 SV=2" "0.000" "False" "8.799" "21" "4" "5" "4" "119" "13.6" "5.38" "8.86" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "8636" "ENSG00000176101" "SSNA1" "hsa:8636; O43805; Q5VSG0; Q6FG70; Q9BVW8" "Ciliary landscape" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "8" "0" "1.015" "0.990" "1.044" "1.209" "0.985" "1.058" "1.172" "1.035" "0.829" "236.9" "240.3" "234.5" "247.3" "286.4" "233.4" "250.7" "277.6" "245.2" "196.3" "" "" "" "" "" "" "" "" "" "" "141.8" "124.9" "129.9" "116.1" "132.8" "119.5" "116.6" "124.6" "133.0" "196.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8443695202608012138" "False" "High" "IsMasterProtein" "P49796" "Regulator of G-protein signaling 3 OS=Homo sapiens OX=9606 GN=RGS3 PE=1 SV=2" "0.000" "False" "8.792" "2" "2" "2" "2" "1198" "132.3" "6.28" "7.61" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf00168, Pf00595, Pf00615" "5998" "ENSG00000138835" "RGS3" "A6NHA0; A8K0V1; B3KUB2; hsa:5998; P49796; Q5VXB8; Q5VXC1; Q5VZ05; Q5VZ06; Q6ZRM5; Q8IUQ1; Q8NC47; Q8NFN4; Q8NFN5; Q8NFN6; Q8TD59; Q8TD68; Q8WV02; Q8WXA0" "Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "G alpha (i) signalling events; G alpha (q) signalling events" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-207036045185728456" "False" "High" "IsMasterProtein" "A0A1B0GTU1" "Zinc finger CCCH domain-containing protein 11B OS=Homo sapiens OX=9606 GN=ZC3H11B PE=1 SV=1" "0.000" "False" "8.788" "4" "2" "2" "2" "805" "88.9" "6.81" "6.55" "2" "other metabolic processes;transport" "" "other molecular function" "Pf15663" "" "ENSG00000215817" "ZC3H11B" "A0A1B0GTU1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4342326397945372791" "False" "High" "IsMasterProtein" "O75150" "E3 ubiquitin-protein ligase BRE1B OS=Homo sapiens OX=9606 GN=RNF40 PE=1 SV=5" "0.000" "False" "8.781" "3" "2" "2" "2" "1001" "113.6" "6.29" "6.06" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097" "9810" "ENSG00000103549" "RNF40" "A0A024QZG0; hsa:9810; O75150; Q6AHZ6; Q6N005; Q7L3T6; Q8N615; Q96T18; Q9BSV9; Q9HC82" "ATM signaling in development and disease" "E3 ubiquitin ligases ubiquitinate target proteins" "2" "0" "0.963" "0.877" "0.886" "0.849" "0.961" "1.150" "0.434" "0.894" "3.752" "28.7" "27.7" "25.2" "25.4" "24.4" "27.6" "33.0" "12.5" "25.7" "107.7" "" "" "" "" "" "" "" "" "" "" "17.2" "14.4" "13.9" "11.9" "11.3" "14.1" "15.3" "5.6" "13.9" "107.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2825155014730555615" "False" "High" "IsMasterProtein" "Q6GMV2" "Histone-lysine N-trimethyltransferase SMYD5 OS=Homo sapiens OX=9606 GN=SMYD5 PE=1 SV=2" "0.000" "False" "8.777" "5" "2" "5" "2" "418" "47.3" "5.05" "12.36" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "" "other molecular function" "Pf00856" "10322" "ENSG00000135632" "SMYD5" "D6W5H3; hsa:10322; Q13558; Q6GMV2" "Histone modifications" "" "1" "0" "0.907" "1.006" "1.208" "1.000" "1.077" "1.017" "0.921" "0.999" "0.776" "203.0" "184.1" "204.2" "245.2" "203.1" "218.7" "206.5" "187.1" "202.9" "157.6" "" "" "" "" "" "" "" "" "" "" "121.5" "95.7" "113.1" "115.1" "94.1" "112.0" "96.0" "84.0" "110.1" "157.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8479423548841098522" "False" "High" "IsMasterProtein" "P21283" "V-type proton ATPase subunit C 1 OS=Homo sapiens OX=9606 GN=ATP6V1C1 PE=1 SV=4" "0.000" "False" "8.766" "8" "4" "4" "4" "382" "43.9" "7.46" "9.48" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity" "Pf03223" "528" "ENSG00000155097" "ATP6V1C1" "hsa:528; P21283" "Proximal tubule transport" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "6" "0" "1.178" "1.364" "1.061" "1.132" "1.165" "1.035" "0.762" "1.222" "3.144" "191.3" "225.4" "260.9" "203.0" "216.6" "222.8" "197.9" "145.7" "233.8" "601.4" "" "" "" "" "" "" "" "" "" "" "114.5" "117.1" "144.5" "95.3" "100.4" "114.0" "92.0" "65.4" "126.8" "601.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6922732359213996073" "False" "High" "IsMasterProtein" "Q9H4L7" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 OS=Homo sapiens OX=9606 GN=SMARCAD1 PE=1 SV=2" "0.000" "False" "8.766" "4" "2" "3" "2" "1026" "117.3" "5.55" "5.09" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "56916" "ENSG00000163104" "SMARCAD1" "B7Z799; hsa:56916; Q05D56; Q96SX1; Q9H017; Q9H4L7; Q9H860; Q9NPU9; Q9ULU7" "" "" "0" "0" "1.110" "0.848" "1.045" "1.197" "0.848" "0.996" "1.718" "0.998" "1.237" "20.1" "22.3" "17.1" "21.0" "24.1" "17.1" "20.0" "34.5" "20.1" "24.9" "" "" "" "" "" "" "" "" "" "" "12.0" "11.6" "9.4" "9.9" "11.2" "8.7" "9.3" "15.5" "10.9" "24.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6713269859164182683" "False" "High" "IsMasterProtein" "P08567" "Pleckstrin OS=Homo sapiens OX=9606 GN=PLEK PE=1 SV=3" "0.000" "False" "8.759" "8" "2" "2" "2" "350" "40.1" "8.28" "6.72" "2" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00169, Pf00610" "5341" "ENSG00000115956" "PLEK" "B2R9E8; hsa:5341; P08567; Q53SU8; Q6FGM8; Q6FGQ1; Q8WV81" "Serotonin and anxiety-related events; TYROBP causal network in microglia; Serotonin and anxiety" "Platelet degranulation" "4" "0" "0.906" "1.891" "2.190" "1.859" "1.211" "1.355" "1.154" "1.830" "7.465" "10.4" "9.4" "19.7" "22.8" "19.4" "12.6" "14.1" "12.0" "19.1" "77.7" "" "" "" "" "" "" "" "" "" "" "6.2" "4.9" "10.9" "10.7" "9.0" "6.5" "6.6" "5.4" "10.3" "77.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-599104977835536313" "False" "High" "IsMasterProtein" "P28799" "Progranulin OS=Homo sapiens OX=9606 GN=GRN PE=1 SV=2" "0.000" "False" "8.755" "6" "4" "4" "4" "593" "63.5" "6.83" "6.20" "4" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "signal transduction activity or receptor binding;other molecular function" "Pf00396" "2896" "ENSG00000030582" "GRN" "D3DX55; hsa:2896; P23781; P23782; P23783; P23784; P28799; Q53HQ8; Q53Y88; Q540U8; Q9BWE7; Q9H8S1; Q9UCH0" "IL-18 signaling pathway" "Neutrophil degranulation" "2" "0" "1.519" "1.289" "0.806" "1.504" "0.918" "0.841" "0.627" "0.884" "1.482" "19.9" "30.2" "25.6" "16.0" "29.9" "18.3" "16.7" "12.5" "17.6" "29.5" "" "" "" "" "" "" "" "" "" "" "11.9" "15.7" "14.2" "7.5" "13.9" "9.3" "7.8" "5.6" "9.5" "29.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5845152794455651809" "False" "High" "IsMasterProtein" "O75179" "Ankyrin repeat domain-containing protein 17 OS=Homo sapiens OX=9606 GN=ANKRD17 PE=1 SV=3" "0.000" "False" "8.754" "2" "4" "4" "4" "2603" "274.1" "6.52" "5.87" "4" "stress response;developmental processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf00013, Pf12796, Pf13637" "26057" "ENSG00000132466" "ANKRD17" "E7EUV3; G5E964; hsa:26057; O75179; Q6PJ85; Q6PK85; Q6PKA2; Q86XI3; Q8NDR5; Q96I86; Q9H288; Q9H6J9" "" "" "0" "0" "0.962" "1.209" "0.643" "1.140" "0.925" "1.151" "0.562" "1.088" "3.271" "33.8" "32.5" "40.9" "21.8" "38.6" "31.3" "38.9" "19.0" "36.8" "110.6" "" "" "" "" "" "" "" "" "" "" "20.2" "16.9" "22.6" "10.2" "17.9" "16.0" "18.1" "8.5" "20.0" "110.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2799145337949175211" "False" "High" "IsMasterProtein" "O15294" "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Homo sapiens OX=9606 GN=OGT PE=1 SV=3" "0.000" "False" "8.737" "3" "3" "3" "3" "1046" "116.9" "6.70" "7.03" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00515, Pf13181, Pf13414, Pf13424, Pf13844" "8473" "ENSG00000147162" "OGT" "hsa:8473; O15294; Q7Z3K0; Q8WWM8; Q96CC1; Q9UG57" "Ectoderm differentiation; Ectoderm differentiation; Pleural mesothelioma" "UCH proteinases; Formation of WDR5-containing histone-modifying complexes; Regulation of necroptotic cell death; HATs acetylate histones" "8" "0" "1.050" "0.752" "1.134" "1.334" "1.343" "0.523" "0.915" "0.932" "5.413" "28.6" "30.0" "21.5" "32.4" "38.1" "38.4" "14.9" "26.1" "26.6" "154.6" "" "" "" "" "" "" "" "" "" "" "17.1" "15.6" "11.9" "15.2" "17.7" "19.6" "6.9" "11.7" "14.4" "154.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7858307060055438950" "False" "High" "IsMasterProtein" "Q9HAB8" "Phosphopantothenate--cysteine ligase OS=Homo sapiens OX=9606 GN=PPCS PE=1 SV=2" "0.000" "False" "8.727" "8" "3" "4" "3" "311" "34.0" "6.71" "8.21" "3" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04127" "79717" "ENSG00000127125" "PPCS" "hsa:79717; Q3KQT2; Q5VVM0; Q9HAB8" "" "Coenzyme A biosynthesis" "1" "0" "0.968" "0.933" "1.066" "0.871" "1.080" "1.003" "0.997" "1.021" "0.809" "379.7" "367.5" "354.2" "405.0" "330.6" "410.0" "380.7" "378.5" "387.8" "307.4" "" "" "" "" "" "" "" "" "" "" "227.2" "191.0" "196.1" "190.1" "153.3" "209.9" "177.0" "169.9" "210.4" "307.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5593923735961542225" "False" "High" "IsMasterProtein" "Q9BRG1" "Vacuolar protein-sorting-associated protein 25 OS=Homo sapiens OX=9606 GN=VPS25 PE=1 SV=1" "0.000" "False" "8.721" "16" "3" "3" "3" "176" "20.7" "6.34" "7.31" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05871" "84313" "ENSG00000131475" "VPS25" "B2R581; hsa:84313; Q9BRG1" "" "Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5305679341133587567" "False" "High" "IsMasterProtein" "Q86WR0" "Coiled-coil domain-containing protein 25 OS=Homo sapiens OX=9606 GN=CCDC25 PE=1 SV=2" "0.000" "False" "8.718" "11" "2" "3" "2" "208" "24.5" "6.80" "4.84" "2" "other biological processes" "plasma membrane;other membranes;other cell component" "nucleic acid binding activity" "Pf05670" "55246" "ENSG00000147419" "CCDC25" "hsa:55246; Q0P663; Q86WR0; Q96SI2; Q9NV98" "" "" "0" "0" "0.913" "1.311" "1.106" "1.290" "1.186" "1.160" "0.651" "1.075" "5.138" "36.9" "33.7" "48.4" "40.8" "47.6" "43.8" "42.9" "24.0" "39.7" "189.7" "" "" "" "" "" "" "" "" "" "" "22.1" "17.5" "26.8" "19.2" "22.1" "22.4" "19.9" "10.8" "21.5" "189.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2207555378581959897" "False" "High" "IsMasterProtein" "Q14761" "Protein tyrosine phosphatase receptor type C-associated protein OS=Homo sapiens OX=9606 GN=PTPRCAP PE=1 SV=1" "0.000" "False" "8.704" "12" "2" "2" "2" "206" "21.2" "4.55" "3.59" "2" "stress response" "plasma membrane;other membranes" "" "Pf15713" "5790" "ENSG00000213402" "PTPRCAP" "B2R512; hsa:5790; O00643; Q14761; Q6I9S6" "TNF-alpha signaling pathway" "" "1" "0" "1.136" "0.987" "1.426" "1.059" "0.989" "1.373" "1.317" "1.059" "0.633" "123.6" "140.4" "122.0" "176.3" "131.0" "122.2" "169.8" "162.8" "130.9" "78.2" "" "" "" "" "" "" "" "" "" "" "74.0" "73.0" "67.6" "82.8" "60.7" "62.6" "78.9" "73.1" "71.0" "78.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7722178459817833286" "False" "High" "IsMasterProtein" "P61970" "Nuclear transport factor 2 OS=Homo sapiens OX=9606 GN=NUTF2 PE=1 SV=1" "0.000" "False" "8.692" "17" "2" "16" "2" "127" "14.5" "5.38" "37.05" "2" "transport;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf02136" "10204" "ENSG00000102898" "NUTF2" "B2R4G7; hsa:10204; P13662; P61970; Q6IB67" "" "" "0" "0" "0.945" "0.943" "1.058" "1.016" "0.959" "0.967" "0.981" "0.948" "0.541" "539.3" "509.8" "508.6" "570.5" "547.7" "517.3" "521.5" "529.2" "511.4" "292.0" "" "" "" "" "" "" "" "" "" "" "322.7" "264.9" "281.7" "267.8" "253.9" "264.8" "242.5" "237.6" "277.5" "292.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4621514541592481866" "False" "High" "IsMasterProtein" "O75376" "Nuclear receptor corepressor 1 OS=Homo sapiens OX=9606 GN=NCOR1 PE=1 SV=2" "0.000" "False" "8.686" "1" "2" "2" "2" "2440" "270.0" "7.11" "6.42" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf15784" "9611" "ENSG00000141027" "NCOR1" "B3DLF8; E9PGV6; hsa:9611; O75376; Q86YY0; Q9UPV5; Q9UQ18" "Androgen receptor signaling pathway; Adipogenesis; Ovarian infertility; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Rett syndrome; 22q11.2 copy number variation syndrome; Notch signaling pathway" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Nuclear signaling by ERBB4; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NR1D1 (REV-ERBA) represses gene expression; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis" "30" "0" "1.485" "0.795" "1.009" "1.448" "1.331" "1.470" "0.814" "0.873" "1.590" "33.7" "50.0" "26.8" "34.0" "48.8" "44.8" "49.5" "27.4" "29.4" "53.6" "" "" "" "" "" "" "" "" "" "" "20.2" "26.0" "14.8" "16.0" "22.6" "23.0" "23.0" "12.3" "15.9" "53.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7530688595643988973" "False" "High" "IsMasterProtein" "Q13510" "Acid ceramidase OS=Homo sapiens OX=9606 GN=ASAH1 PE=1 SV=5" "0.000" "False" "8.686" "7" "3" "3" "3" "395" "44.6" "7.62" "4.93" "3" "other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02275, Pf15508" "427" "ENSG00000104763" "ASAH1" "E9PDS0; hsa:427; Q13510; Q6W898; Q96AS2" "Sphingolipid pathway; S1P receptor signal transduction; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence; Biosynthesis and turnover of 1-deoxy-sphingoid bases; Synthesis of ceramides and 1-deoxyceramides" "Neutrophil degranulation; Glycosphingolipid catabolism" "8" "0" "1.260" "1.564" "1.095" "1.373" "1.451" "1.406" "2.077" "1.473" "0.645" "23.6" "29.8" "36.9" "25.9" "32.4" "34.3" "33.2" "49.1" "34.8" "15.2" "" "" "" "" "" "" "" "" "" "" "14.1" "15.5" "20.5" "12.1" "15.0" "17.5" "15.4" "22.0" "18.9" "15.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2555536461123867922" "False" "High" "IsMasterProtein" "Q86U90" "Threonylcarbamoyl-AMP synthase OS=Homo sapiens OX=9606 GN=YRDC PE=1 SV=1" "0.000" "False" "8.675" "9" "2" "5" "2" "279" "29.3" "8.57" "9.85" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01300" "79693" "ENSG00000196449" "YRDC" "hsa:79693; Q4W4X8; Q6NVW3; Q7L4E4; Q7Z2I4; Q86U90; Q9H5F8" "" "" "0" "0" "1.004" "1.092" "1.065" "1.251" "1.168" "1.092" "0.983" "0.847" "1.219" "66.5" "66.7" "72.6" "70.8" "83.1" "77.6" "72.6" "65.4" "56.3" "81.0" "" "" "" "" "" "" "" "" "" "" "39.8" "34.7" "40.2" "33.2" "38.5" "39.7" "33.8" "29.3" "30.5" "81.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7162742285351111146" "False" "High" "IsMasterProtein" "Q13330" "Metastasis-associated protein MTA1 OS=Homo sapiens OX=9606 GN=MTA1 PE=1 SV=2" "0.000" "False" "8.666" "4" "3" "3" "1" "715" "80.7" "9.26" "5.46" "3" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "9112" "ENSG00000182979" "MTA1" "A5PLK4; hsa:9112; Q13330; Q86SW2; Q8NFI8; Q96GI8" "Effect of progerin on genes involved in progeria; TAR syndrome" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; SUMOylation of transcription factors" "8" "0" "1.148" "0.963" "1.031" "1.198" "1.405" "1.064" "1.104" "1.154" "1.540" "88.6" "101.7" "85.4" "91.3" "106.2" "124.5" "94.3" "97.8" "102.3" "136.5" "" "" "" "" "" "" "" "" "" "" "53.0" "52.9" "47.3" "42.9" "49.2" "63.7" "43.9" "43.9" "55.5" "136.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8790717896449630852" "False" "High" "IsMasterProtein" "Q9UPT8" "Zinc finger CCCH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=ZC3H4 PE=1 SV=3" "0.000" "False" "8.655" "3" "3" "3" "3" "1303" "140.2" "6.27" "2.36" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608, Pf18044" "23211" "ENSG00000130749" "ZC3H4" "hsa:23211; Q9UPT8; Q9Y420" "" "" "0" "0" "0.837" "1.003" "1.105" "0.807" "0.960" "0.893" "0.984" "0.777" "0.517" "70.9" "59.3" "71.2" "78.4" "57.2" "68.1" "63.4" "69.8" "55.1" "36.7" "" "" "" "" "" "" "" "" "" "" "42.4" "30.8" "39.4" "36.8" "26.5" "34.9" "29.5" "31.3" "29.9" "36.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9075280951894741873" "False" "High" "IsMasterProtein" "Q9NQP4" "Prefoldin subunit 4 OS=Homo sapiens OX=9606 GN=PFDN4 PE=1 SV=1" "0.000" "False" "8.636" "20" "2" "3" "2" "134" "15.3" "4.53" "2.88" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01920" "5203" "ENSG00000101132" "PFDN4" "hsa:5203; Q5TD11; Q92779; Q9NQP4" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "1.098" "1.042" "1.155" "0.936" "1.340" "1.100" "1.363" "1.214" "0.464" "136.8" "150.3" "142.6" "158.1" "128.0" "183.4" "150.5" "186.5" "166.1" "63.5" "" "" "" "" "" "" "" "" "" "" "81.9" "78.1" "79.0" "74.2" "59.3" "93.9" "70.0" "83.7" "90.1" "63.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6056381579766233841" "False" "High" "IsMasterProtein" "Q9UNH7" "Sorting nexin-6 OS=Homo sapiens OX=9606 GN=SNX6 PE=1 SV=1" "0.000" "False" "8.636" "6" "3" "4" "3" "406" "46.6" "6.16" "11.94" "3" "transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00787, Pf09325" "58533" "ENSG00000129515" "SNX6" "C0H5W9; hsa:58533; Q9UNH7; Q9Y449" "" "" "0" "0" "1.003" "1.121" "1.171" "1.147" "1.231" "1.211" "0.411" "1.184" "7.596" "218.6" "219.1" "244.9" "255.9" "250.7" "269.2" "264.7" "89.9" "258.7" "1660.3" "" "" "" "" "" "" "" "" "" "" "130.8" "113.9" "135.6" "120.1" "116.2" "137.8" "123.1" "40.3" "140.4" "1660.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3538184499835993456" "False" "High" "IsMasterProtein" "P43897" "Elongation factor Ts, mitochondrial OS=Homo sapiens OX=9606 GN=TSFM PE=1 SV=2" "0.000" "False" "8.634" "9" "2" "3" "2" "325" "35.4" "8.38" "9.26" "2" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity" "Pf00889" "10102" "ENSG00000123297" "TSFM" "B4E391; F5H2T7; hsa:10102; P43897; Q561V7; Q8TBC2; Q9UQK0" "" "Mitochondrial translation elongation" "1" "0" "1.086" "1.295" "0.010" "1.932" "0.882" "1.697" "0.466" "1.493" "16.695" "5.7" "6.2" "7.4" "0.0" "11.0" "5.0" "9.6" "2.6" "8.5" "94.9" "" "" "" "" "" "" "" "" "" "" "3.4" "3.2" "4.1" "0.0" "5.1" "2.6" "4.5" "1.2" "4.6" "94.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2629792950046784631" "False" "High" "IsMasterProtein" "Q12849" "G-rich sequence factor 1 OS=Homo sapiens OX=9606 GN=GRSF1 PE=1 SV=3" "0.000" "False" "8.619" "6" "3" "3" "3" "480" "53.1" "6.19" "8.09" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "2926" "ENSG00000132463" "GRSF1" "B3KPW0; hsa:2926; Q12849; Q4W5S5; Q6ZST3; Q8IWD6; Q8NBD2" "VEGFA-VEGFR2 signaling" "Viral mRNA Translation; Mitochondrial RNA degradation" "3" "0" "0.811" "1.023" "0.962" "1.312" "0.924" "0.945" "0.139" "0.992" "9.066" "59.2" "48.0" "60.5" "56.9" "77.6" "54.7" "55.9" "8.3" "58.7" "536.2" "" "" "" "" "" "" "" "" "" "" "35.4" "24.9" "33.5" "26.7" "36.0" "28.0" "26.0" "3.7" "31.8" "536.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-253239951813173210" "False" "High" "IsMasterProtein" "Q9H2M9" "Rab3 GTPase-activating protein non-catalytic subunit OS=Homo sapiens OX=9606 GN=RAB3GAP2 PE=1 SV=1" "0.000" "False" "8.609" "2" "3" "4" "3" "1393" "155.9" "5.62" "9.29" "3" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf14655, Pf14656" "25782" "ENSG00000118873" "RAB3GAP2" "A6H8V0; hsa:25782; O75872; Q9H2M9; Q9HAB0; Q9UFJ7; Q9UQ15" "" "RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic" "2" "0" "1.019" "1.034" "1.276" "1.048" "0.996" "1.096" "0.496" "1.056" "5.865" "113.9" "116.1" "117.8" "145.4" "119.3" "113.4" "124.8" "56.5" "120.2" "667.9" "" "" "" "" "" "" "" "" "" "" "68.2" "60.3" "65.2" "68.2" "55.3" "58.1" "58.0" "25.4" "65.2" "667.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "115101743397248701" "False" "High" "IsMasterProtein" "Q15528" "Mediator of RNA polymerase II transcription subunit 22 OS=Homo sapiens OX=9606 GN=MED22 PE=1 SV=2" "0.000" "False" "8.587" "16" "3" "5" "3" "200" "22.2" "4.68" "8.91" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf06179" "6837" "ENSG00000148297; ENSG00000281022" "MED22" "B3KW83; B3KWX4; hsa:6837; O76072; Q15528; Q5T8U0" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "3" "0" "1.224" "1.142" "1.169" "1.280" "1.298" "1.489" "1.160" "1.173" "2.164" "47.8" "58.4" "54.6" "55.8" "61.2" "62.0" "71.1" "55.4" "56.0" "103.4" "" "" "" "" "" "" "" "" "" "" "28.6" "30.4" "30.2" "26.2" "28.3" "31.7" "33.1" "24.9" "30.4" "103.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4043384267201458756" "False" "High" "IsMasterProtein" "Q8TBX8" "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma OS=Homo sapiens OX=9606 GN=PIP4K2C PE=1 SV=3" "0.000" "False" "8.586" "5" "2" "3" "2" "421" "47.3" "6.84" "7.05" "2" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf01504" "79837" "ENSG00000166908" "PIP4K2C" "B2RDL3; B4DM11; B4DY44; hsa:79837; Q8TBX8; Q9H6N2" "Regulation of actin cytoskeleton" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "5" "0" "1.388" "1.052" "1.279" "1.253" "1.161" "1.092" "1.174" "1.266" "4.337" "86.6" "120.2" "91.1" "110.7" "108.5" "100.5" "94.6" "101.7" "109.6" "375.6" "" "" "" "" "" "" "" "" "" "" "51.8" "62.5" "50.4" "52.0" "50.3" "51.5" "44.0" "45.6" "59.5" "375.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2637590011477773491" "False" "High" "IsMasterProtein" "P46459" "Vesicle-fusing ATPase OS=Homo sapiens OX=9606 GN=NSF PE=1 SV=3" "0.000" "False" "8.579" "5" "4" "5" "4" "744" "82.5" "6.95" "10.45" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00004, Pf02359, Pf02933, Pf17862" "4905" "ENSG00000073969; ENSG00000276262; ENSG00000278174" "NSF" "A8K2D9; B4DFA2; P46459; Q8N6D7; Q9UKZ2" "Synaptic vesicle pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Vasopressin-regulated water reabsorption" "COPII-mediated vesicle transport; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network; Trafficking of GluR2-containing AMPA receptors" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "938742805709954505" "False" "High" "IsMasterProtein" "Q9H3F6" "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 OS=Homo sapiens OX=9606 GN=KCTD10 PE=1 SV=1" "0.000" "False" "8.574" "11" "4" "6" "4" "313" "35.4" "6.34" "11.26" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02214" "83892" "ENSG00000110906" "KCTD10" "hsa:83892; Q53HN2; Q59FV1; Q6PL47; Q96SU0; Q9H3F6" "" "" "0" "0" "0.925" "0.927" "0.968" "1.002" "1.024" "0.986" "1.024" "0.915" "0.954" "259.9" "240.4" "240.9" "251.6" "260.4" "266.1" "256.3" "266.1" "237.9" "247.9" "" "" "" "" "" "" "" "" "" "" "155.6" "124.9" "133.4" "118.1" "120.7" "136.2" "119.2" "119.5" "129.0" "247.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1789067979643489698" "False" "High" "IsMasterProtein" "P46976" "Glycogenin-1 OS=Homo sapiens OX=9606 GN=GYG1 PE=1 SV=4" "0.000" "False" "8.558" "7" "2" "9" "2" "350" "39.4" "5.53" "14.18" "2" "other metabolic processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01501" "2992" "ENSG00000163754" "GYG1" "D3DNH0; D3DNH1; D3DNH2; hsa:2992; P46976; Q6FHZ1; Q9UNV0" "Insulin signaling; Glycogen synthesis and degradation; Disorders of galactose metabolism" "Neutrophil degranulation; Glycogen synthesis; Glycogen breakdown (glycogenolysis); Myoclonic epilepsy of Lafora; Glycogen storage disease type II (GAA); Glycogen storage disease type XV (GYG1); Glycogen storage disease type 0 (muscle GYS1)" "10" "0" "0.965" "0.986" "1.053" "1.089" "0.953" "1.111" "1.136" "1.025" "0.599" "184.7" "178.3" "182.1" "194.4" "201.1" "175.9" "205.3" "209.9" "189.2" "110.7" "" "" "" "" "" "" "" "" "" "" "110.5" "92.6" "100.8" "91.3" "93.2" "90.1" "95.4" "94.2" "102.7" "110.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7841395992400372766" "False" "High" "IsMasterProtein" "Q9NVG8" "TBC1 domain family member 13 OS=Homo sapiens OX=9606 GN=TBC1D13 PE=1 SV=3" "0.000" "False" "8.547" "6" "2" "2" "2" "400" "46.5" "5.24" "6.23" "2" "transport" "other membranes;cytosol" "enzyme regulator activity;other molecular function" "Pf00566" "54662" "ENSG00000107021" "TBC1D13" "A7E2E7; B3KW04; B9EGJ8; hsa:54662; Q5T270; Q5T271; Q9NVG8" "" "TBC/RABGAPs" "1" "0" "1.048" "0.827" "1.105" "0.876" "1.120" "1.138" "0.893" "1.090" "0.906" "79.6" "83.4" "65.9" "88.0" "69.8" "89.2" "90.6" "71.1" "86.8" "72.2" "" "" "" "" "" "" "" "" "" "" "47.7" "43.4" "36.5" "41.3" "32.3" "45.7" "42.1" "31.9" "47.1" "72.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9211506236520866705" "False" "High" "IsMasterProtein" "O76071" "Probable cytosolic iron-sulfur protein assembly protein CIAO1 OS=Homo sapiens OX=9606 GN=CIAO1 PE=1 SV=1" "0.000" "False" "8.546" "7" "3" "4" "3" "339" "37.8" "4.97" "10.77" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "" "Pf00400" "9391" "ENSG00000144021" "CIAO1" "A0MNN9; hsa:9391; O76071; Q53FM5" "2q11.2 copy number variation syndrome" "Cytosolic iron-sulfur cluster assembly" "2" "0" "1.159" "0.952" "1.141" "0.869" "0.912" "0.914" "0.881" "1.116" "0.936" "91.1" "105.6" "86.7" "104.0" "79.2" "83.1" "83.3" "80.3" "101.7" "85.4" "" "" "" "" "" "" "" "" "" "" "54.5" "54.9" "48.0" "48.8" "36.7" "42.5" "38.7" "36.0" "55.2" "85.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9072204051848657082" "False" "High" "IsMasterProtein" "O75832" "26S proteasome non-ATPase regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PSMD10 PE=1 SV=1" "0.000" "False" "8.543" "10" "1" "1" "1" "226" "24.4" "6.10" "5.63" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf12796" "5716" "ENSG00000101843" "PSMD10" "hsa:5716; O75832; Q5U0B2; Q8IZK9" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "61" "0" "0.943" "1.420" "1.095" "0.920" "1.131" "1.047" "1.055" "0.900" "2.731" "18.1" "17.1" "25.7" "19.8" "16.7" "20.5" "19.0" "19.1" "16.3" "49.5" "" "" "" "" "" "" "" "" "" "" "10.8" "8.9" "14.2" "9.3" "7.7" "10.5" "8.8" "8.6" "8.8" "49.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8378095313839820512" "False" "High" "IsMasterProtein" "P15923" "Transcription factor E2-alpha OS=Homo sapiens OX=9606 GN=TCF3 PE=1 SV=1" "0.000" "False" "8.537" "4" "2" "2" "2" "654" "67.6" "6.47" "5.61" "2" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "6929" "ENSG00000071564" "TCF3" "hsa:6929; P15883; P15923; Q14208; Q14635; Q14636; Q2TB39; Q2TB40; Q9UPI9" "Ectoderm differentiation; Ectoderm differentiation; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; lncRNA in canonical Wnt signaling and colorectal cancer; Neurogenesis regulation in the olfactory epithelium; Sudden infant death syndrome (SIDS) susceptibility pathways" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Myogenesis" "9" "0" "1.041" "1.071" "0.840" "0.803" "1.131" "0.996" "1.138" "1.025" "1.757" "33.7" "35.1" "36.1" "28.3" "27.1" "38.2" "33.6" "38.4" "34.6" "59.3" "" "" "" "" "" "" "" "" "" "" "20.2" "18.3" "20.0" "13.3" "12.6" "19.5" "15.6" "17.2" "18.8" "59.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3161881869701219173" "False" "High" "IsMasterProtein" "O43715" "TP53-regulated inhibitor of apoptosis 1 OS=Homo sapiens OX=9606 GN=TRIAP1 PE=1 SV=1" "0.000" "False" "8.532" "28" "2" "3" "2" "76" "8.8" "5.48" "6.84" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf05254" "51499" "ENSG00000170855" "TRIAP1" "B2R4Z7; hsa:51499; O43715; Q5RKS5; Q6LCA7" "5q35 copy number variation" "Mitochondrial protein degradation; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" "3" "0" "0.916" "0.866" "1.007" "0.941" "1.036" "1.196" "1.035" "0.925" "0.550" "97.7" "89.4" "84.5" "98.4" "91.9" "101.2" "116.8" "101.1" "90.3" "53.7" "" "" "" "" "" "" "" "" "" "" "58.5" "46.5" "46.8" "46.2" "42.6" "51.8" "54.3" "45.4" "49.0" "53.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9023390433505774979" "False" "High" "IsMasterProtein" "P53597" "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG1 PE=1 SV=4" "0.000" "False" "8.525" "7" "2" "5" "2" "346" "36.2" "8.79" "13.71" "2" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00549, Pf02629" "8802" "ENSG00000163541" "SUCLG1" "hsa:8802; P53597; Q9BWB0; Q9UNP6" "Amino acid metabolism; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle)" "3" "0" "1.088" "0.999" "1.012" "1.216" "1.126" "1.230" "1.003" "0.983" "2.632" "188.9" "205.5" "188.8" "191.2" "229.7" "212.8" "232.5" "189.5" "185.7" "497.4" "" "" "" "" "" "" "" "" "" "" "113.1" "106.8" "104.6" "89.8" "106.5" "109.0" "108.1" "85.1" "100.8" "497.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8966117974293097362" "False" "High" "IsMasterProtein" "Q9UHL4" "Dipeptidyl peptidase 2 OS=Homo sapiens OX=9606 GN=DPP7 PE=1 SV=3" "0.000" "False" "8.495" "8" "3" "4" "3" "492" "54.3" "6.32" "8.73" "3" "protein metabolism;other metabolic processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05577" "29952" "ENSG00000176978" "DPP7" "A8K7U7; hsa:29952; Q5VSF1; Q969X4; Q9UHL4" "" "Neutrophil degranulation" "1" "0" "0.869" "0.964" "1.184" "1.159" "0.915" "0.823" "1.036" "0.817" "0.707" "49.7" "43.2" "47.9" "58.8" "57.5" "45.4" "40.9" "51.4" "40.5" "35.1" "" "" "" "" "" "" "" "" "" "" "29.7" "22.4" "26.5" "27.6" "26.7" "23.2" "19.0" "23.1" "22.0" "35.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5077095867447308247" "False" "High" "IsMasterProtein" "Q9BY77" "Polymerase delta-interacting protein 3 OS=Homo sapiens OX=9606 GN=POLDIP3 PE=1 SV=2" "0.000" "False" "8.492" "6" "2" "2" "2" "421" "46.1" "9.99" "6.62" "2" "other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "84271" "ENSG00000100227" "POLDIP3" "A8K6F8; A8K6V9; hsa:84271; Q009A7; Q5H972; Q6PGN6; Q7Z6Z0; Q9BY77; Q9NSP5; Q9NSP6" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "3" "0" "0.969" "0.858" "0.791" "1.018" "0.881" "1.036" "0.763" "0.954" "1.148" "29.6" "28.7" "25.4" "23.4" "30.1" "26.1" "30.6" "22.6" "28.2" "34.0" "" "" "" "" "" "" "" "" "" "" "17.7" "14.9" "14.1" "11.0" "14.0" "13.3" "14.2" "10.1" "15.3" "34.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7485362868972298733" "False" "High" "IsMasterProtein" "P14174" "Macrophage migration inhibitory factor OS=Homo sapiens OX=9606 GN=MIF PE=1 SV=4" "0.000" "False" "8.467" "14" "2" "27" "2" "115" "12.5" "7.88" "68.94" "2" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01187" "4282" "ENSG00000240972; ENSG00000276701" "MIF" "A5Z1R8; B2R4S3; hsa:4282; P14174; Q2V4Y5; Q6FHV0" "Adipogenesis; Spinal cord injury; HDAC6 interactions in the central nervous system" "Neutrophil degranulation; Cell surface interactions at the vascular wall; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "6" "0" "0.904" "0.866" "0.948" "0.989" "0.886" "1.014" "0.948" "0.885" "0.523" "1491.3" "1348.1" "1292.1" "1414.0" "1474.9" "1321.2" "1512.1" "1413.3" "1319.4" "780.0" "" "" "" "" "" "" "" "" "" "" "892.5" "700.6" "715.5" "663.8" "683.7" "676.4" "703.1" "634.5" "715.8" "780.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8649705542655534815" "False" "High" "IsMasterProtein" "Q8N573" "Oxidation resistance protein 1 OS=Homo sapiens OX=9606 GN=OXR1 PE=1 SV=2" "0.000" "False" "8.467" "3" "3" "3" "3" "874" "97.9" "5.47" "5.74" "3" "stress response;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf01476, Pf07534" "55074" "ENSG00000164830" "OXR1" "A6NK11; A8KA34; B3KXL1; B7Z402; B7Z8N5; D3HIS6; hsa:55074; Q3LIB5; Q6ZVK9; Q8N573; Q8N8V0; Q9H266; Q9NWC7" "" "" "0" "0" "1.328" "0.941" "1.066" "1.101" "1.185" "1.026" "1.081" "0.987" "0.820" "113.9" "151.2" "107.1" "121.4" "125.4" "135.0" "116.9" "123.1" "112.4" "93.4" "" "" "" "" "" "" "" "" "" "" "68.2" "78.6" "59.3" "57.0" "58.1" "69.1" "54.4" "55.3" "61.0" "93.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1630996109560083637" "False" "High" "IsMasterProtein" "O75909" "Cyclin-K OS=Homo sapiens OX=9606 GN=CCNK PE=1 SV=2" "0.000" "False" "8.462" "6" "3" "5" "3" "580" "64.2" "8.41" "9.21" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00134, Pf21797" "8812" "ENSG00000090061" "CCNK" "hsa:8812; O75909; Q59FT6; Q86U16; Q96B63; Q9NNY9" "Male infertility" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes" "10" "0" "1.068" "1.035" "1.010" "0.892" "1.046" "1.058" "1.160" "1.066" "0.543" "191.6" "204.6" "198.3" "193.5" "170.9" "200.5" "202.8" "222.2" "204.2" "104.1" "" "" "" "" "" "" "" "" "" "" "114.7" "106.3" "109.8" "90.8" "79.2" "102.6" "94.3" "99.8" "110.8" "104.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5468856902780976606" "False" "High" "IsMasterProtein" "O60884" "DnaJ homolog subfamily A member 2 OS=Homo sapiens OX=9606 GN=DNAJA2 PE=1 SV=1" "0.000" "False" "8.460" "7" "3" "3" "3" "412" "45.7" "6.48" "8.79" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf00226, Pf00684, Pf01556" "10294" "ENSG00000069345" "DNAJA2" "B2R7L7; hsa:10294; O14711; O60884" "" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "1" "0" "0.690" "1.021" "0.945" "0.983" "0.881" "0.980" "0.728" "0.948" "4.378" "92.2" "63.6" "94.1" "87.1" "90.6" "81.2" "90.3" "67.1" "87.4" "403.5" "" "" "" "" "" "" "" "" "" "" "55.2" "33.1" "52.1" "40.9" "42.0" "41.6" "42.0" "30.1" "47.4" "403.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6782447041087316008" "False" "High" "IsMasterProtein" "Q9UNF0" "Protein kinase C and casein kinase substrate in neurons protein 2 OS=Homo sapiens OX=9606 GN=PACSIN2 PE=1 SV=2" "0.000" "False" "8.447" "6" "3" "3" "3" "486" "55.7" "5.20" "6.81" "3" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00611, Pf14604" "11252" "ENSG00000100266" "PACSIN2" "hsa:11252; O95921; Q96HV9; Q9H0D3; Q9NPN1; Q9UNF0; Q9Y4V2" "" "Clathrin-mediated endocytosis" "1" "0" "1.117" "1.126" "1.677" "0.934" "1.106" "1.400" "0.865" "1.008" "3.061" "37.3" "41.7" "42.0" "62.5" "34.8" "41.2" "52.2" "32.2" "37.6" "114.1" "" "" "" "" "" "" "" "" "" "" "22.3" "21.6" "23.2" "29.4" "16.1" "21.1" "24.3" "14.5" "20.4" "114.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "504093738677667823" "False" "High" "IsMasterProtein" "O14867" "Transcription regulator protein BACH1 OS=Homo sapiens OX=9606 GN=BACH1 PE=1 SV=2" "0.000" "False" "8.429" "6" "3" "3" "3" "736" "81.9" "5.05" "3.54" "3" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651, Pf03131" "571" "ENSG00000156273" "BACH1" "hsa:571; O14867; O43285; Q6ICU0" "Integrated cancer pathway; Ferroptosis" "Heme signaling; Regulation of HMOX1 expression and activity; Regulation of BACH1 activity; NFE2L2 regulating anti-oxidant/detoxification enzymes" "6" "0" "1.242" "0.897" "1.279" "0.921" "1.375" "1.282" "0.755" "1.072" "1.098" "25.5" "31.7" "22.9" "32.6" "23.5" "35.1" "32.7" "19.3" "27.4" "28.0" "" "" "" "" "" "" "" "" "" "" "15.3" "16.5" "12.7" "15.3" "10.9" "18.0" "15.2" "8.6" "14.8" "28.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6083245125138804483" "False" "High" "IsMasterProtein" "Q15027" "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ACAP1 PE=1 SV=1" "0.000" "False" "8.423" "5" "3" "3" "3" "740" "81.5" "7.66" "6.57" "3" "transport" "other membranes;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00023, Pf00169, Pf01412, Pf16746" "9744" "ENSG00000072818; ENSG00000288169" "ACAP1" "hsa:9744; Q15027; Q53XN9" "Nucleotide-binding oligomerization domain (NOD) pathway" "" "1" "0" "1.010" "0.901" "0.954" "1.361" "1.160" "1.527" "0.851" "0.989" "4.998" "34.2" "34.6" "30.8" "32.7" "46.6" "39.7" "52.3" "29.1" "33.9" "171.2" "" "" "" "" "" "" "" "" "" "" "20.5" "18.0" "17.1" "15.3" "21.6" "20.3" "24.3" "13.1" "18.4" "171.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2874142018275296018" "False" "High" "IsMasterProtein" "A6NHR9" "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SMCHD1 PE=1 SV=2" "0.000" "False" "8.422" "1" "2" "2" "2" "2005" "226.2" "7.30" "6.67" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06470, Pf13589" "23347" "ENSG00000101596" "SMCHD1" "A6NHR9; O75141; Q6AHX6; Q6ZTQ8; Q9H6Q2; Q9UG39" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3306595998206250770" "False" "High" "IsMasterProtein" "P62753" "Small ribosomal subunit protein eS6 OS=Homo sapiens OX=9606 GN=RPS6 PE=1 SV=1" "0.000" "False" "8.415" "10" "3" "3" "3" "249" "28.7" "10.84" "7.43" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01092" "6194" "ENSG00000137154" "RPS6" "hsa:6194; P08227; P10660; P62753; Q4VBY7; Q8N6Z7" "IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; IL-2 signaling pathway; Pleural mesothelioma; 2q37 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways" "SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; Protein hydroxylation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nuclear events stimulated by ALK signaling in cancer; SARS-CoV-1 modulates host translation machinery" "49" "0" "0.999" "1.088" "0.994" "1.099" "1.038" "0.931" "0.898" "1.166" "2.207" "292.3" "292.0" "318.0" "290.5" "321.3" "303.5" "272.0" "262.4" "340.7" "645.3" "" "" "" "" "" "" "" "" "" "" "174.9" "151.7" "176.1" "136.4" "148.9" "155.3" "126.5" "117.8" "184.9" "645.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "714954485545523239" "False" "High" "IsMasterProtein" "P27986" "Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Homo sapiens OX=9606 GN=PIK3R1 PE=1 SV=2" "0.000" "False" "8.409" "5" "3" "3" "3" "724" "83.5" "6.16" "7.13" "3" "cell adhesion;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00620, Pf16454" "5295" "ENSG00000145675" "PIK3R1" "B3KT19; D3DWA0; E7EX19; hsa:5295; P27986; Q15747; Q4VBZ7; Q53EM6; Q8IXA2; Q8N1C5" "IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Apoptosis; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; PDGFR-beta pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Overview of interferons-mediated signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; IL-18 signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; Interferon type I signaling pathways; Notch signaling pathway; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "G alpha (q) signalling events; Extra-nuclear estrogen signaling; RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RAF/MAP kinase cascade; PI3K Cascade; PI-3K cascade:FGFR4; Signaling by FGFR4 in disease; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; RHOC GTPase cycle; Downstream TCR signaling; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; RHOU GTPase cycle; Synthesis of PIPs at the plasma membrane; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle; Interleukin-4 and Interleukin-13 signaling; PI3K events in ERBB4 signaling; PI3K events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; GAB1 signalosome; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by CSF1 (M-CSF) in myeloid cells; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; Signaling by FGFR2 in disease; PI-3K cascade:FGFR3; Signaling by FGFR3 in disease; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; GP1b-IX-V activation signalling; MET activates PI3K/AKT signaling; Activated NTRK3 signals through PI3K; Activated NTRK2 signals through PI3K" "154" "0" "1.139" "0.913" "1.584" "1.091" "0.962" "1.652" "1.520" "1.285" "4.126" "15.2" "17.3" "13.8" "24.0" "16.5" "14.6" "25.0" "23.0" "19.5" "62.5" "" "" "" "" "" "" "" "" "" "" "9.1" "9.0" "7.7" "11.3" "7.7" "7.5" "11.6" "10.3" "10.6" "62.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3307427478696066462" "False" "High" "IsMasterProtein" "Q96AJ9" "Vesicle transport through interaction with t-SNAREs homolog 1A OS=Homo sapiens OX=9606 GN=VTI1A PE=1 SV=2" "0.000" "False" "8.399" "14" "3" "4" "3" "217" "25.2" "6.40" "10.15" "3" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05008, Pf12352" "143187" "ENSG00000151532" "VTI1A" "A2A307; B4E137; hsa:143187; Q5W0D7; Q96AJ9" "" "Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "2" "0" "1.044" "0.819" "1.025" "0.941" "0.854" "1.077" "0.942" "1.189" "0.833" "132.2" "138.0" "108.3" "135.4" "124.3" "112.9" "142.4" "124.5" "157.2" "110.1" "" "" "" "" "" "" "" "" "" "" "79.1" "71.7" "60.0" "63.6" "57.6" "57.8" "66.2" "55.9" "85.3" "110.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2939925399894006679" "False" "High" "IsMasterProtein" "Q9NWU2" "Glucose-induced degradation protein 8 homolog OS=Homo sapiens OX=9606 GN=GID8 PE=1 SV=1" "0.000" "False" "8.377" "14" "3" "4" "3" "228" "26.7" "4.97" "5.67" "3" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08513, Pf10607" "54994" "ENSG00000101193" "GID8" "E1P5I3; hsa:54994; Q8N5M5; Q9NWU2" "Ciliary landscape" "" "1" "0" "1.354" "1.335" "1.388" "1.427" "1.196" "1.472" "0.881" "1.343" "2.415" "82.6" "111.8" "110.3" "114.6" "117.9" "98.7" "121.5" "72.7" "110.9" "199.4" "" "" "" "" "" "" "" "" "" "" "49.4" "58.1" "61.1" "53.8" "54.6" "50.5" "56.5" "32.7" "60.2" "199.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3128972635678329678" "False" "High" "IsMasterProtein" "Q9BUT1" "Dehydrogenase/reductase SDR family member 6 OS=Homo sapiens OX=9606 GN=BDH2 PE=1 SV=2" "0.000" "False" "8.372" "9" "2" "2" "2" "245" "26.7" "7.65" "3.98" "2" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13561" "56898" "ENSG00000164039" "BDH2" "A8K295; B4DUF6; hsa:56898; Q503A0; Q6IA46; Q6UWD3; Q9BUT1; Q9H8S8; Q9NRX8" "" "Synthesis of Ketone Bodies" "1" "0" "1.298" "1.471" "1.413" "1.066" "1.171" "1.370" "1.371" "1.189" "2.384" "30.7" "39.9" "45.2" "43.4" "32.8" "36.0" "42.1" "42.1" "36.5" "73.2" "" "" "" "" "" "" "" "" "" "" "18.4" "20.7" "25.0" "20.4" "15.2" "18.4" "19.6" "18.9" "19.8" "73.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1587907933929237870" "False" "High" "IsMasterProtein" "Q02548" "Paired box protein Pax-5 OS=Homo sapiens OX=9606 GN=PAX5 PE=1 SV=1" "0.000" "False" "8.372" "7" "2" "2" "2" "391" "42.1" "9.00" "7.09" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00292, Pf12403" "5079" "ENSG00000196092" "PAX5" "A3QVP6; A3QVP7; A3QVP8; C0KTF6; C0KTF7; C0KTF8; C0KTF9; C0KTG0; hsa:5079; O75933; Q02548; Q5SFM2; Q6S728; Q6S729; Q6S730; Q6S731; Q6S732" "Prion disease pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; ID signaling pathway" "RUNX1 regulates transcription of genes involved in BCR signaling" "4" "0" "1.138" "1.152" "1.119" "1.232" "1.129" "1.213" "1.078" "1.025" "1.116" "78.1" "88.9" "90.0" "87.4" "96.2" "88.2" "94.7" "84.2" "80.0" "87.2" "" "" "" "" "" "" "" "" "" "" "46.7" "46.2" "49.8" "41.0" "44.6" "45.1" "44.1" "37.8" "43.4" "87.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5945011317712517661" "False" "High" "IsMasterProtein" "P25787" "Proteasome subunit alpha type-2 OS=Homo sapiens OX=9606 GN=PSMA2 PE=1 SV=2" "0.000" "False" "8.369" "12" "3" "15" "3" "234" "25.9" "7.43" "38.03" "3" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5683" "ENSG00000106588" "PSMA2" "hsa:5683; P25787; Q6ICS6; Q9BU45" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Antigen processing: Ubiquitination & Proteasome degradation; Downstream TCR signaling; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "1.019" "1.050" "1.091" "1.167" "1.034" "0.989" "1.127" "1.077" "0.704" "385.2" "392.3" "404.3" "420.2" "449.3" "398.3" "380.8" "434.2" "415.0" "271.1" "" "" "" "" "" "" "" "" "" "" "230.5" "203.9" "223.9" "197.3" "208.3" "203.9" "177.0" "194.9" "225.1" "271.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5200719085873833637" "False" "High" "IsMasterProtein" "Q8NFW8" "N-acylneuraminate cytidylyltransferase OS=Homo sapiens OX=9606 GN=CMAS PE=1 SV=2" "0.000" "False" "8.359" "6" "3" "3" "3" "434" "48.3" "7.93" "8.59" "3" "other metabolic processes" "nucleus" "other molecular function" "Pf02348" "55907" "ENSG00000111726" "CMAS" "hsa:55907; Q8NFW8; Q96AX5; Q9NQZ0" "Sialylation" "Sialic acid metabolism" "2" "0" "0.718" "0.748" "0.929" "0.680" "0.856" "0.747" "0.700" "1.041" "5.099" "20.4" "14.6" "15.3" "18.9" "13.9" "17.4" "15.2" "14.3" "21.2" "103.9" "" "" "" "" "" "" "" "" "" "" "12.2" "7.6" "8.4" "8.9" "6.4" "8.9" "7.1" "6.4" "11.5" "103.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3327789120096563661" "False" "High" "IsMasterProtein" "Q9NR56" "Muscleblind-like protein 1 OS=Homo sapiens OX=9606 GN=MBNL1 PE=1 SV=2" "0.000" "False" "8.353" "7" "3" "8" "3" "388" "41.8" "8.90" "20.29" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608" "4154" "ENSG00000152601" "MBNL1" "E9PBW7; hsa:4154; O43311; O43797; Q86UV8; Q86UV9; Q96P92; Q96RE3; Q9NR56" "Adipogenesis" "" "1" "0" "0.988" "0.985" "0.963" "0.967" "0.918" "1.018" "1.049" "1.004" "0.859" "515.6" "509.6" "507.8" "496.7" "498.8" "473.6" "525.0" "540.7" "517.5" "442.9" "" "" "" "" "" "" "" "" "" "" "308.6" "264.8" "281.2" "233.2" "231.2" "242.4" "244.1" "242.7" "280.8" "442.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2632668230264232030" "False" "High" "IsMasterProtein" "P61024" "Cyclin-dependent kinases regulatory subunit 1 OS=Homo sapiens OX=9606 GN=CKS1B PE=1 SV=1" "0.000" "False" "8.353" "28" "3" "4" "2" "79" "9.7" "8.94" "13.76" "3" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01111" "1163" "ENSG00000173207" "CKS1B" "hsa:1163; P33551; P61024" "Small cell lung cancer" "SCF(Skp2)-mediated degradation of p27/p21; Cyclin D associated events in G1" "3" "1" "1.012" "1.028" "0.995" "1.134" "1.138" "0.974" "1.014" "0.960" "0.964" "640.5" "647.9" "658.2" "637.3" "726.1" "728.8" "624.0" "649.2" "615.0" "617.5" "" "" "" "" "" "" "" "" "" "" "383.3" "336.7" "364.5" "299.2" "336.6" "373.1" "290.2" "291.5" "333.7" "617.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "467994795181612484" "False" "High" "IsMasterProtein" "Q92793" "CREB-binding protein OS=Homo sapiens OX=9606 GN=CREBBP PE=1 SV=3" "0.000" "False" "8.349" "1" "2" "2" "2" "2442" "265.2" "8.53" "5.91" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00569, Pf02135, Pf02172, Pf06001, Pf08214, Pf09030" "1387" "ENSG00000005339" "CREBBP" "D3DUC9; O00147; Q16376; Q4LE28; Q92793" "Androgen receptor signaling pathway; Angiogenesis; TNF-alpha signaling pathway; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; IL6 signaling pathway; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; miRNA regulation of prostate cancer signaling pathways; Wnt signaling pathway and pluripotency; Clear cell renal cell carcinoma pathways; Ebola virus infection in host; Type 2 papillary renal cell carcinoma; Ciliary landscape; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; 15q13.3 copy number variation syndrome; Urotensin-II-mediated signaling pathway; Rubinstein-Taybi syndrome 1; 15q11q13 copy number variation; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "Heme signaling; NFE2L2 regulating anti-oxidant/detoxification enzymes; Transcriptional regulation of white adipocyte differentiation; SUMOylation of transcription cofactors; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Zygotic genome activation (ZGA); PPARA activates gene expression; NPAS4 regulates expression of target genes; Formation of the beta-catenin:TCF transactivating complex; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); HATs acetylate histones; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; NFE2L2 regulating MDR associated enzymes; Nuclear events mediated by NFE2L2; NFE2L2 regulates pentose phosphate pathway genes; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; NFE2L2 regulating inflammation associated genes; NFE2L2 regulating tumorigenic genes; NFE2L2 regulating ER-stress associated genes; Regulation of NFE2L2 gene expression; RORA activates gene expression; Attenuation phase; CD209 (DC-SIGN) signaling; Activation of the TFAP2 (AP-2) family of transcription factors; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; Regulation of gene expression by Hypoxia-inducible Factor; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production" "74" "0" "1.012" "0.776" "1.708" "1.253" "0.724" "1.168" "1.020" "0.815" "1.881" "27.2" "27.5" "21.1" "46.4" "34.0" "19.7" "31.8" "27.7" "22.1" "51.1" "" "" "" "" "" "" "" "" "" "" "16.3" "14.3" "11.7" "21.8" "15.8" "10.1" "14.8" "12.4" "12.0" "51.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2857218708684993243" "False" "High" "IsMasterProtein" "Q9Y315" "Deoxyribose-phosphate aldolase OS=Homo sapiens OX=9606 GN=DERA PE=1 SV=2" "0.000" "False" "8.347" "11" "2" "2" "2" "318" "35.2" "8.94" "6.05" "2" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01791" "51071" "ENSG00000023697" "DERA" "hsa:51071; Q53HN9; Q6PHW2; Q9Y315" "Pentose phosphate pathway in senescent cells" "Neutrophil degranulation; Pentose phosphate pathway" "3" "0" "0.730" "1.477" "1.000" "1.233" "1.748" "1.274" "0.657" "1.179" "0.872" "20.6" "15.0" "30.4" "20.6" "25.4" "36.0" "26.2" "13.5" "24.3" "18.0" "" "" "" "" "" "" "" "" "" "" "12.3" "7.8" "16.8" "9.7" "11.8" "18.4" "12.2" "6.1" "13.2" "18.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2291665734159650582" "False" "High" "IsMasterProtein" "P62310" "U6 snRNA-associated Sm-like protein LSm3 OS=Homo sapiens OX=9606 GN=LSM3 PE=1 SV=2" "0.000" "False" "8.343" "12" "1" "7" "1" "102" "11.8" "4.70" "20.54" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "27258" "ENSG00000170860" "LSM3" "hsa:27258; P62310; Q6IAH0; Q9Y4Z1" "" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "2" "0" "1.136" "1.047" "1.289" "1.091" "0.966" "1.195" "1.149" "0.956" "1.150" "365.9" "415.7" "383.1" "471.5" "399.3" "353.4" "437.0" "420.3" "349.8" "420.9" "" "" "" "" "" "" "" "" "" "" "218.9" "216.0" "212.2" "221.4" "185.1" "180.9" "203.2" "188.7" "189.8" "420.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5010086175827698668" "False" "High" "IsMasterProtein" "P42575" "Caspase-2 OS=Homo sapiens OX=9606 GN=CASP2 PE=1 SV=2" "0.000" "False" "8.341" "6" "2" "2" "2" "452" "50.7" "6.81" "7.47" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00619, Pf00656" "835" "ENSG00000106144" "CASP2" "A8K5F9; D3DXD6; E9PDN0; hsa:835; P42575; P42576; Q59F21; Q7KZL6; Q86UJ3; Q9BUP7; Q9BZK9; Q9BZL0" "Apoptosis modulation and signaling; Parkinson's disease pathway; Apoptosis; Apoptosis modulation by HSP70; Acute viral myocarditis" "TP53 Regulates Transcription of Caspase Activators and Caspases; NOD1/2 Signaling Pathway; NADE modulates death signalling" "8" "0" "1.155" "1.267" "1.240" "1.227" "1.020" "1.177" "0.937" "1.041" "2.534" "83.7" "96.7" "106.1" "103.8" "102.7" "85.4" "98.5" "78.5" "87.2" "212.1" "" "" "" "" "" "" "" "" "" "" "50.1" "50.3" "58.8" "48.7" "47.6" "43.7" "45.8" "35.2" "47.3" "212.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7855128710481582123" "False" "High" "IsMasterProtein" "P50238" "Cysteine-rich protein 1 OS=Homo sapiens OX=9606 GN=CRIP1 PE=1 SV=3" "0.000" "False" "8.339" "31" "3" "7" "3" "77" "8.5" "8.75" "20.67" "3" "stress response;developmental processes;signal transduction;other biological processes" "other cell component" "other molecular function" "Pf00412" "1396" "ENSG00000213145" "CRIP1" "H3BPI2; hsa:1396; P50238; Q13628; Q53XY7; Q96J34" "" "" "0" "0" "0.935" "0.969" "0.848" "1.003" "0.899" "0.938" "1.042" "0.920" "0.455" "750.1" "701.2" "726.9" "636.0" "752.6" "674.2" "703.4" "781.4" "689.8" "341.1" "" "" "" "" "" "" "" "" "" "" "448.9" "364.4" "402.6" "298.6" "348.8" "345.2" "327.1" "350.8" "374.3" "341.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-815619529761870657" "False" "High" "IsMasterProtein" "Q6P996" "Pyridoxal-dependent decarboxylase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PDXDC1 PE=1 SV=2" "0.000" "False" "8.338" "4" "2" "2" "2" "788" "86.7" "5.38" "6.06" "2" "other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf00282" "23042" "ENSG00000179889; ENSG00000275498" "PDXDC1" "B4DR55; B4DSL3; E7EMH5; E7EPL4; H3BNZ1; hsa:23042; O00236; Q4F6X7; Q6P996; Q6PID7; Q86YF1; Q8N4Q9; Q8TBS5" "" "" "0" "0" "0.869" "0.706" "1.353" "0.799" "1.062" "1.506" "1.146" "0.907" "1.555" "17.3" "15.0" "12.2" "23.4" "13.8" "18.4" "26.1" "19.8" "15.7" "26.9" "" "" "" "" "" "" "" "" "" "" "10.4" "7.8" "6.8" "11.0" "6.4" "9.4" "12.1" "8.9" "8.5" "26.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8721939623497573862" "False" "High" "IsMasterProtein" "Q86YV5" "Inactive tyrosine-protein kinase PRAG1 OS=Homo sapiens OX=9606 GN=PRAG1 PE=1 SV=4" "0.000" "False" "8.327" "3" "2" "2" "2" "1406" "149.5" "7.20" "4.36" "2" "other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf07714" "157285" "ENSG00000275342" "PRAG1" "Q86YV5; Q8N3N5" "" "RND2 GTPase cycle" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7112262159952005485" "False" "High" "IsMasterProtein" "Q5T440" "Putative transferase CAF17, mitochondrial OS=Homo sapiens OX=9606 GN=IBA57 PE=1 SV=1" "0.000" "False" "8.325" "4" "1" "2" "1" "356" "38.1" "9.83" "7.49" "1" "cell organization and biogenesis;other metabolic processes" "mitochondrion" "other molecular function" "" "200205" "ENSG00000181873" "IBA57" "hsa:200205; Q5T440" "" "" "0" "0" "1.119" "0.981" "1.120" "1.172" "0.813" "1.350" "0.952" "1.179" "1.084" "31.5" "35.2" "30.9" "35.2" "36.9" "25.6" "42.5" "29.9" "37.1" "34.1" "" "" "" "" "" "" "" "" "" "" "18.8" "18.3" "17.1" "16.5" "17.1" "13.1" "19.8" "13.4" "20.1" "34.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4293840026169595064" "False" "High" "IsMasterProtein" "Q6ZVK8" "8-oxo-dGDP phosphatase NUDT18 OS=Homo sapiens OX=9606 GN=NUDT18 PE=1 SV=3" "0.000" "False" "8.317" "9" "2" "2" "2" "323" "35.5" "6.23" "6.31" "2" "other metabolic processes" "cytosol" "other molecular function" "Pf00293" "79873" "ENSG00000275074" "NUDT18" "hsa:79873; Q6ZVK8; Q8IZ75; Q9H687" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7182522188647620429" "False" "High" "IsMasterProtein" "Q8N3L3" "Beta-taxilin OS=Homo sapiens OX=9606 GN=TXLNB PE=1 SV=3" "0.000" "False" "8.310" "4" "2" "2" "2" "684" "76.5" "4.93" "5.31" "2" "" "other cell component" "other molecular function" "Pf09728" "167838" "ENSG00000164440" "TXLNB" "hsa:167838; Q5HYH7; Q5VTF3; Q76L25; Q86T52; Q8N3L3; Q8N3S2" "" "" "0" "0" "0.756" "0.924" "0.931" "1.075" "1.076" "1.049" "0.814" "0.991" "0.893" "40.1" "30.3" "37.0" "37.3" "43.1" "43.1" "42.0" "32.6" "39.7" "35.8" "" "" "" "" "" "" "" "" "" "" "24.0" "15.7" "20.5" "17.5" "20.0" "22.1" "19.5" "14.6" "21.5" "35.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8350052096889729945" "False" "High" "IsMasterProtein" "O95670" "V-type proton ATPase subunit G 2 OS=Homo sapiens OX=9606 GN=ATP6V1G2 PE=1 SV=1" "0.000" "False" "8.310" "17" "1" "1" "1" "118" "13.6" "10.26" "4.90" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf03179" "534" "ENSG00000206445; ENSG00000213760; ENSG00000226850; ENSG00000227587; ENSG00000230900; ENSG00000234668; ENSG00000234920" "ATP6V1G2" "B5MEF0; hsa:534; O95670; Q2L6F8; Q5HYU8; Q5RJ63" "" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3291285492636401918" "False" "High" "IsMasterProtein" "Q9H974" "Queuine tRNA-ribosyltransferase accessory subunit 2 OS=Homo sapiens OX=9606 GN=QTRT2 PE=1 SV=1" "0.000" "False" "8.303" "10" "4" "4" "4" "415" "46.7" "6.81" "6.84" "4" "RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01702" "79691" "ENSG00000151576" "QTRT2" "A6NGE9; B7Z472; B7Z5R2; hsa:79691; J3KR78; Q6IA59; Q9H974" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.028" "0.949" "0.949" "1.107" "1.138" "1.058" "0.895" "1.082" "0.899" "156.2" "160.6" "148.2" "148.3" "173.0" "177.8" "165.2" "139.8" "169.1" "140.5" "" "" "" "" "" "" "" "" "" "" "93.5" "83.5" "82.1" "69.6" "80.2" "91.0" "76.8" "62.8" "91.7" "140.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7629254407620291846" "False" "High" "IsMasterProtein" "Q15428" "Splicing factor 3A subunit 2 OS=Homo sapiens OX=9606 GN=SF3A2 PE=1 SV=2" "0.000" "False" "8.250" "5" "2" "3" "2" "464" "49.2" "9.64" "3.94" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf12874, Pf16835" "8175" "ENSG00000104897" "SF3A2" "B2RBU1; D6W605; hsa:8175; O75245; Q15428" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7903736519056340786" "False" "High" "IsMasterProtein" "P53985" "Monocarboxylate transporter 1 OS=Homo sapiens OX=9606 GN=SLC16A1 PE=1 SV=3" "0.000" "False" "8.221" "6" "3" "3" "3" "500" "53.9" "8.66" "5.65" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "transporter activity;other molecular function" "" "6566" "ENSG00000155380; ENSG00000281917" "SLC16A1" "hsa:6566; P53985; Q49A45; Q5T8R6; Q9NSJ9" "Photodynamic therapy-induced HIF-1 survival signaling; Fragile X syndrome; Glucose metabolism in triple-negative breast cancer cells" "Pyruvate metabolism; Aspirin ADME; Basigin interactions; Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)" "8" "0" "1.058" "0.845" "1.052" "0.862" "0.730" "1.095" "1.004" "0.943" "0.302" "51.8" "54.8" "43.8" "54.6" "44.7" "37.8" "56.8" "52.1" "48.9" "15.7" "" "" "" "" "" "" "" "" "" "" "31.0" "28.5" "24.3" "25.6" "20.7" "19.4" "26.4" "23.4" "26.5" "15.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4563440572163449089" "False" "High" "IsMasterProtein" "P60520" "Gamma-aminobutyric acid receptor-associated protein-like 2 OS=Homo sapiens OX=9606 GN=GABARAPL2 PE=1 SV=1" "0.000" "False" "8.217" "19" "3" "12" "3" "117" "13.7" "8.10" "24.70" "3" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02991" "11345" "ENSG00000034713" "GABARAPL2" "hsa:11345; O08765; P60520; Q6FG91; Q9DCP8; Q9UQF7" "Network map of SARS-CoV-2 signaling pathway; 2q37 copy number variation syndrome; 8q11.23 (RB1CC1) copy number variation" "TBC/RABGAPs; Macroautophagy" "5" "0" "1.039" "1.099" "1.087" "1.190" "1.054" "1.057" "1.133" "1.080" "1.169" "1072.8" "1115.1" "1179.2" "1166.2" "1276.6" "1131.1" "1133.6" "1215.1" "1158.9" "1254.0" "" "" "" "" "" "" "" "" "" "" "642.0" "579.5" "653.0" "547.5" "591.7" "579.0" "527.1" "545.5" "628.8" "1254.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7603913648578901731" "False" "High" "IsMasterProtein" "Q5VWZ2" "Lysophospholipase-like protein 1 OS=Homo sapiens OX=9606 GN=LYPLAL1 PE=1 SV=3" "0.000" "False" "8.212" "11" "3" "7" "3" "237" "26.3" "7.84" "18.86" "3" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02230" "127018" "ENSG00000143353" "LYPLAL1" "A8K677; hsa:127018; Q5VWZ2; Q5VWZ3; Q7Z4A3; Q96AV0" "" "" "0" "0" "0.971" "1.059" "0.956" "1.002" "1.024" "1.059" "0.879" "0.933" "1.882" "311.5" "302.5" "330.0" "298.0" "312.1" "318.9" "329.9" "273.9" "290.6" "586.4" "" "" "" "" "" "" "" "" "" "" "186.4" "157.2" "182.7" "139.9" "144.7" "163.2" "153.4" "123.0" "157.7" "586.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7527678404860705700" "False" "High" "IsMasterProtein" "Q96K21" "Abscission/NoCut checkpoint regulator OS=Homo sapiens OX=9606 GN=ZFYVE19 PE=1 SV=3" "0.000" "False" "8.210" "8" "3" "3" "3" "471" "51.5" "5.73" "5.44" "3" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf01363" "84936" "ENSG00000166140" "ZFYVE19" "B3KVB2; C9JNF4; H3BUF9; hsa:84936; Q86WC2; Q8WU96; Q96K21" "" "" "0" "0" "1.335" "1.242" "1.423" "1.157" "1.448" "1.448" "1.613" "1.644" "0.690" "36.8" "49.1" "45.7" "52.3" "42.5" "53.2" "53.2" "59.3" "60.4" "25.3" "" "" "" "" "" "" "" "" "" "" "22.0" "25.5" "25.3" "24.6" "19.7" "27.2" "24.7" "26.6" "32.8" "25.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2769761607326504072" "False" "High" "IsMasterProtein" "Q9Y3P9" "Rab GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RABGAP1 PE=1 SV=3" "0.000" "False" "8.210" "4" "4" "4" "4" "1069" "121.7" "5.25" "7.52" "4" "cell cycle OR cell proliferation;other biological processes" "cytosol;cytoskeleton" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00566, Pf00640, Pf12473" "23637" "ENSG00000011454" "RABGAP1" "B9A6L2; hsa:23637; Q05CW2; Q6ZMY1; Q9HA28; Q9P0E2; Q9UG67; Q9Y3P9" "" "TBC/RABGAPs" "1" "0" "1.151" "1.030" "0.923" "0.997" "0.925" "0.874" "0.932" "0.865" "2.658" "89.4" "102.8" "92.0" "82.5" "89.1" "82.6" "78.1" "83.3" "77.3" "237.6" "" "" "" "" "" "" "" "" "" "" "53.5" "53.4" "51.0" "38.7" "41.3" "42.3" "36.3" "37.4" "42.0" "237.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8321925279742634811" "False" "High" "IsMasterProtein" "Q9Y6Y8" "SEC23-interacting protein OS=Homo sapiens OX=9606 GN=SEC23IP PE=1 SV=1" "0.000" "False" "8.183" "2" "2" "2" "2" "1000" "111.0" "5.54" "5.38" "2" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00536, Pf02825, Pf02862" "11196" "ENSG00000107651" "SEC23IP" "D3DRD2; hsa:11196; Q8IXH5; Q9BUK5; Q9Y6Y8" "" "COPII-mediated vesicle transport" "1" "0" "1.297" "1.571" "1.185" "1.189" "1.605" "0.908" "0.331" "1.162" "8.458" "19.4" "25.1" "30.4" "22.9" "23.0" "31.1" "17.6" "6.4" "22.5" "163.7" "" "" "" "" "" "" "" "" "" "" "11.6" "13.0" "16.8" "10.8" "10.7" "15.9" "8.2" "2.9" "12.2" "163.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3792046426100688845" "False" "High" "IsMasterProtein" "O43395" "U4/U6 small nuclear ribonucleoprotein Prp3 OS=Homo sapiens OX=9606 GN=PRPF3 PE=1 SV=2" "0.000" "False" "8.175" "4" "3" "3" "3" "683" "77.5" "9.50" "5.29" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01480, Pf06544, Pf08572" "9129" "ENSG00000117360" "PRPF3" "B4DSY9; hsa:9129; O43395; O43446; Q5VT54" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.996" "1.295" "1.255" "1.391" "1.303" "1.422" "1.029" "1.219" "6.061" "20.6" "20.5" "26.7" "25.8" "28.7" "26.8" "29.3" "21.2" "25.1" "124.8" "" "" "" "" "" "" "" "" "" "" "12.3" "10.7" "14.8" "12.1" "13.3" "13.7" "13.6" "9.5" "13.6" "124.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4010780836197462310" "False" "High" "IsMasterProtein" "Q15427" "Splicing factor 3B subunit 4 OS=Homo sapiens OX=9606 GN=SF3B4 PE=1 SV=1" "0.000" "False" "8.164" "3" "1" "2" "1" "424" "44.4" "8.56" "5.18" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "10262" "ENSG00000143368" "SF3B4" "hsa:10262; Q15427; Q5SZ63" "mRNA processing; 10q22q23 copy number variation" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "4" "0" "1.536" "1.322" "1.100" "1.163" "1.049" "1.247" "1.523" "1.294" "1.209" "28.9" "44.5" "38.3" "31.8" "33.7" "30.4" "36.1" "44.1" "37.4" "35.0" "" "" "" "" "" "" "" "" "" "" "17.3" "23.1" "21.2" "14.9" "15.6" "15.5" "16.8" "19.8" "20.3" "35.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3369137616140023088" "False" "High" "IsMasterProtein" "Q9NZJ9" "Diphosphoinositol polyphosphate phosphohydrolase 2 OS=Homo sapiens OX=9606 GN=NUDT4 PE=1 SV=2" "0.000" "False" "8.158" "17" "3" "4" "1" "180" "20.3" "6.35" "8.35" "3" "other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "11163" "ENSG00000173598" "NUDT4" "B7Z916; hsa:11163; Q4AEJ6; Q53EZ2; Q68DD7; Q9NPC5; Q9NS30; Q9NZJ9; Q9NZK0; Q9NZK1" "" "Synthesis of pyrophosphates in the cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "Not Found" "High" "High" "High" "High" "1" "" "7331213768411445402" "False" "High" "IsMasterProtein" "O95777" "U6 snRNA-associated Sm-like protein LSm8 OS=Homo sapiens OX=9606 GN=LSM8 PE=1 SV=3" "0.000" "False" "8.149" "20" "2" "7" "2" "96" "10.4" "4.48" "15.77" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "51691" "ENSG00000128534" "LSM8" "hsa:51691; O95777" "" "mRNA Splicing - Major Pathway" "1" "0" "1.061" "0.943" "0.977" "1.039" "1.040" "1.110" "1.150" "1.054" "0.608" "239.9" "254.5" "226.1" "234.3" "249.3" "249.6" "266.3" "276.0" "252.8" "145.9" "" "" "" "" "" "" "" "" "" "" "143.6" "132.2" "125.2" "110.0" "115.6" "127.8" "123.8" "123.9" "137.1" "145.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6183242122487478565" "False" "High" "IsMasterProtein" "Q8TDP1" "Ribonuclease H2 subunit C OS=Homo sapiens OX=9606 GN=RNASEH2C PE=1 SV=1" "0.000" "False" "8.146" "15" "2" "3" "2" "164" "17.8" "5.03" "7.95" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "" "Pf08615" "84153" "ENSG00000172922" "RNASEH2C" "hsa:84153; Q8TDP1; Q9H7F5" "" "" "0" "0" "1.205" "1.057" "0.920" "1.018" "1.030" "0.665" "0.545" "0.855" "6.990" "25.5" "30.7" "26.9" "23.4" "25.9" "26.2" "16.9" "13.9" "21.8" "178.0" "" "" "" "" "" "" "" "" "" "" "15.2" "15.9" "14.9" "11.0" "12.0" "13.4" "7.9" "6.2" "11.8" "178.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7697367026041443041" "False" "High" "IsMasterProtein" "Q96A49" "Synapse-associated protein 1 OS=Homo sapiens OX=9606 GN=SYAP1 PE=1 SV=1" "0.000" "False" "8.139" "7" "2" "2" "2" "352" "39.9" "4.53" "5.79" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf03909" "94056" "ENSG00000169895" "SYAP1" "hsa:94056; Q68CP1; Q96A49; Q96C60; Q96JQ6; Q96T20" "" "" "0" "0" "1.126" "1.153" "0.803" "1.327" "1.143" "0.922" "1.140" "0.878" "0.969" "24.5" "27.6" "28.3" "19.7" "32.6" "28.0" "22.6" "28.0" "21.5" "23.8" "" "" "" "" "" "" "" "" "" "" "14.7" "14.4" "15.7" "9.2" "15.1" "14.4" "10.5" "12.6" "11.7" "23.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5285928462194255524" "False" "High" "IsMasterProtein" "Q9H6T3" "RNA polymerase II-associated protein 3 OS=Homo sapiens OX=9606 GN=RPAP3 PE=1 SV=2" "0.000" "False" "8.136" "5" "4" "4" "4" "665" "75.7" "6.84" "6.99" "4" "other biological processes" "cytosol;other cell component" "" "Pf00515, Pf13181, Pf13877" "79657" "ENSG00000005175" "RPAP3" "B4DRW9; hsa:79657; Q6PHR5; Q9H6T3" "" "" "0" "0" "1.079" "1.020" "0.881" "1.003" "0.978" "1.113" "0.752" "1.001" "2.788" "228.1" "246.2" "232.7" "200.9" "228.7" "223.0" "253.9" "171.4" "228.4" "635.7" "" "" "" "" "" "" "" "" "" "" "136.5" "127.9" "128.9" "94.3" "106.0" "114.2" "118.0" "77.0" "123.9" "635.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3877552904475964910" "False" "High" "IsMasterProtein" "Q9NX63" "MICOS complex subunit MIC19 OS=Homo sapiens OX=9606 GN=CHCHD3 PE=1 SV=1" "0.000" "False" "8.126" "10" "2" "2" "2" "227" "26.1" "8.28" "7.16" "2" "cell organization and biogenesis" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf05300" "54927" "ENSG00000106554" "CHCHD3" "hsa:54927; Q9NX63" "" "Cristae formation; Mitochondrial protein import" "2" "0" "0.879" "0.922" "0.891" "0.947" "0.923" "0.893" "0.977" "0.838" "0.259" "373.9" "328.8" "344.6" "333.0" "354.1" "345.0" "333.8" "365.4" "313.4" "96.9" "" "" "" "" "" "" "" "" "" "" "223.7" "170.8" "190.8" "156.3" "164.1" "176.6" "155.2" "164.0" "170.1" "96.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6009675423733223461" "False" "High" "IsMasterProtein" "Q96B54" "Zinc finger protein 428 OS=Homo sapiens OX=9606 GN=ZNF428 PE=1 SV=2" "0.000" "False" "8.120" "6" "1" "3" "1" "188" "20.5" "4.17" "9.09" "1" "" "" "other molecular function" "" "126299" "ENSG00000131116" "ZNF428" "hsa:126299; O95054; Q6X3Y3; Q96B54" "" "" "0" "0" "0.974" "0.946" "0.928" "0.896" "0.793" "1.262" "1.194" "0.909" "0.285" "65.9" "64.2" "62.4" "61.2" "59.0" "52.3" "83.2" "78.8" "59.9" "18.8" "" "" "" "" "" "" "" "" "" "" "39.5" "33.4" "34.5" "28.7" "27.4" "26.8" "38.7" "35.4" "32.5" "18.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518403686067478951" "False" "High" "IsMasterProtein" "O95149" "Snurportin-1 OS=Homo sapiens OX=9606 GN=SNUPN PE=1 SV=1" "0.000" "False" "8.118" "8" "3" "4" "3" "360" "41.1" "6.64" "8.42" "3" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11538" "10073" "ENSG00000169371" "SNUPN" "A6NE34; A8K0B0; D3DW76; hsa:10073; O95149" "" "snRNP Assembly" "1" "0" "1.224" "1.250" "1.229" "1.295" "1.347" "1.053" "1.167" "1.140" "2.802" "151.1" "184.9" "188.9" "185.6" "195.7" "203.5" "159.2" "176.3" "172.3" "423.4" "" "" "" "" "" "" "" "" "" "" "90.4" "96.1" "104.6" "87.2" "90.7" "104.2" "74.0" "79.2" "93.5" "423.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2272121550069660062" "False" "High" "IsMasterProtein" "P35268" "Large ribosomal subunit protein eL22 OS=Homo sapiens OX=9606 GN=RPL22 PE=1 SV=2" "0.000" "False" "8.118" "20" "2" "3" "2" "128" "14.8" "9.19" "4.06" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01776" "6146" "ENSG00000116251" "RPL22" "B2R495; hsa:6146; P35268; Q6IBD1" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.171" "1.096" "1.475" "1.056" "1.355" "1.147" "1.298" "1.082" "0.855" "26.4" "30.9" "28.9" "38.9" "27.9" "35.7" "30.2" "34.2" "28.5" "22.6" "" "" "" "" "" "" "" "" "" "" "15.8" "16.1" "16.0" "18.3" "12.9" "18.3" "14.1" "15.4" "15.5" "22.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5002411829564885472" "False" "High" "IsMasterProtein" "Q9GZQ8" "Microtubule-associated proteins 1A/1B light chain 3B OS=Homo sapiens OX=9606 GN=MAP1LC3B PE=1 SV=3" "0.000" "False" "8.117" "22" "3" "7" "3" "125" "14.7" "8.94" "15.77" "3" "cell organization and biogenesis;other metabolic processes;stress response" "other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf02991" "81631" "ENSG00000140941" "MAP1LC3B" "hsa:81631; Q6NW02; Q9GZQ8" "Ferroptosis; Autophagy; Opioid receptor pathways; Network map of SARS-CoV-2 signaling pathway; Clock-controlled autophagy in bone metabolism; 2q37 copy number variation syndrome; Autophagy in pancreatic ductal adenocarcinoma" "KEAP1-NFE2L2 pathway; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; PINK1-PRKN Mediated Mitophagy; TBC/RABGAPs; Receptor Mediated Mitophagy; Pexophagy; SARS-CoV-2 modulates autophagy" "16" "0" "1.032" "1.007" "1.144" "1.089" "1.027" "1.103" "1.139" "1.099" "0.829" "708.6" "731.6" "713.6" "810.3" "771.6" "727.6" "781.8" "807.4" "778.9" "587.4" "" "" "" "" "" "" "" "" "" "" "424.1" "380.2" "395.2" "380.4" "357.6" "372.5" "363.5" "362.5" "422.6" "587.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4842107794335973179" "False" "High" "IsMasterProtein" "P15336" "Cyclic AMP-dependent transcription factor ATF-2 OS=Homo sapiens OX=9606 GN=ATF2 PE=1 SV=4" "0.000" "False" "8.115" "8" "2" "2" "1" "505" "54.5" "7.88" "6.93" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "1386" "ENSG00000115966" "ATF2" "A1L3Z2; A4D7U4; A4D7U5; A4D7V1; D3DPE9; G8JLM5; hsa:1386; P15336; Q13000; Q3B7B7; Q4ZFU9; Q53RY2; Q8TAR1; Q96JT8" "Energy metabolism; IL-1 signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; ATM signaling pathway; Interleukin-1 (IL-1) structural pathway; Myometrial relaxation and contraction pathways; Photodynamic therapy-induced AP-1 survival signaling; TGF-beta signaling pathway; MAPK signaling pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; DNA IR-double strand breaks and cellular response via ATM; Ethanol effects on histone modifications; p38 MAPK signaling pathway; PI3K-Akt signaling pathway; Thermogenesis; Gastrin signaling pathway; Hepatitis B infection; Thyroid hormones production and peripheral downstream signaling effects; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; 10q11.21q11.23 copy number variation syndrome; T-cell receptor signaling pathway" "Estrogen-dependent gene expression; HATs acetylate histones; NGF-stimulated transcription; Heme signaling; Regulation of PTEN gene transcription; TP53 Regulates Transcription of DNA Repair Genes; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Activation of the AP-1 family of transcription factors; Response of EIF2AK4 (GCN2) to amino acid deficiency" "36" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3159799509992601123" "False" "High" "IsMasterProtein" "Q96FK6" "WD repeat-containing protein 89 OS=Homo sapiens OX=9606 GN=WDR89 PE=1 SV=1" "0.000" "False" "8.114" "6" "2" "2" "2" "387" "43.2" "6.13" "8.13" "2" "developmental processes" "" "" "Pf00400" "112840" "ENSG00000140006" "WDR89" "hsa:112840; Q96FK6" "" "" "0" "0" "1.024" "1.010" "0.964" "0.987" "0.950" "0.856" "1.045" "0.923" "0.545" "52.9" "54.1" "53.4" "51.0" "52.2" "50.2" "45.3" "55.2" "48.8" "28.8" "" "" "" "" "" "" "" "" "" "" "31.6" "28.1" "29.6" "23.9" "24.2" "25.7" "21.1" "24.8" "26.5" "28.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2991774416485678648" "False" "High" "IsMasterProtein" "P51948" "CDK-activating kinase assembly factor MAT1 OS=Homo sapiens OX=9606 GN=MNAT1 PE=1 SV=1" "0.000" "False" "8.112" "11" "3" "3" "3" "309" "35.8" "6.09" "6.92" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus" "enzyme regulator activity;other molecular function" "Pf06391, Pf17121" "4331" "ENSG00000020426" "MNAT1" "G3V1U8; hsa:4331; P51948; Q15817; Q6ICQ7" "Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "38" "0" "1.194" "1.209" "1.252" "1.273" "1.136" "1.511" "1.141" "1.224" "1.111" "70.1" "83.7" "84.8" "87.8" "89.2" "79.7" "106.0" "80.0" "85.8" "77.9" "" "" "" "" "" "" "" "" "" "" "42.0" "43.5" "47.0" "41.2" "41.4" "40.8" "49.3" "35.9" "46.6" "77.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7819708601940239359" "False" "High" "IsMasterProtein" "P51946" "Cyclin-H OS=Homo sapiens OX=9606 GN=CCNH PE=1 SV=1" "0.000" "False" "8.087" "8" "3" "3" "3" "323" "37.6" "7.15" "7.41" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "enzyme regulator activity" "Pf00134, Pf16899" "902" "ENSG00000134480" "CCNH" "hsa:902; P51946; Q53X72; Q8TBL9" "Cell cycle; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "39" "0" "1.016" "0.879" "0.637" "1.047" "1.256" "0.821" "1.010" "1.178" "1.084" "42.3" "43.0" "37.2" "27.0" "44.3" "53.2" "34.7" "42.8" "49.8" "45.9" "" "" "" "" "" "" "" "" "" "" "25.3" "22.3" "20.6" "12.7" "20.5" "27.2" "16.2" "19.2" "27.0" "45.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1707703891335855171" "False" "High" "IsMasterProtein" "Q7Z478" "ATP-dependent RNA helicase DHX29 OS=Homo sapiens OX=9606 GN=DHX29 PE=1 SV=2" "0.000" "False" "8.062" "2" "3" "3" "3" "1369" "155.1" "8.09" "3.05" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "54505" "ENSG00000067248" "DHX29" "hsa:54505; O75549; Q63HN0; Q63HN3; Q7Z478; Q8IWW2; Q8N3A1; Q9UMH2" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.106" "0.897" "1.002" "0.936" "1.020" "0.864" "0.756" "0.939" "2.584" "58.0" "64.1" "52.0" "58.1" "54.3" "59.1" "50.1" "43.9" "54.5" "149.9" "" "" "" "" "" "" "" "" "" "" "34.7" "33.3" "28.8" "27.3" "25.1" "30.3" "23.3" "19.7" "29.5" "149.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6957065747657519198" "False" "High" "IsMasterProtein" "P33552" "Cyclin-dependent kinases regulatory subunit 2 OS=Homo sapiens OX=9606 GN=CKS2 PE=1 SV=1" "0.000" "False" "8.046" "33" "3" "3" "2" "79" "9.9" "8.46" "9.41" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf01111" "1164" "ENSG00000123975" "CKS2" "hsa:1164; P33552; Q6FGI9; Q6LET5" "Small cell lung cancer" "" "1" "0" "0.931" "1.076" "0.977" "1.129" "1.106" "0.810" "0.861" "0.873" "1.600" "175.6" "163.5" "189.0" "171.6" "198.3" "194.2" "142.3" "151.3" "153.3" "280.9" "" "" "" "" "" "" "" "" "" "" "105.1" "85.0" "104.7" "80.6" "91.9" "99.4" "66.2" "67.9" "83.2" "280.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7864399280568064191" "False" "High" "IsMasterProtein" "Q9BT23" "LIM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=LIMD2 PE=1 SV=1" "0.000" "False" "8.045" "13" "2" "5" "2" "127" "14.1" "9.03" "12.16" "2" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00412" "80774" "ENSG00000136490" "LIMD2" "D3DU16; hsa:80774; Q96S91; Q9BT23" "" "" "0" "0" "1.154" "1.066" "1.057" "1.083" "0.971" "0.926" "0.742" "0.939" "0.498" "191.3" "220.8" "203.9" "202.1" "207.1" "185.7" "177.0" "141.9" "179.6" "95.3" "" "" "" "" "" "" "" "" "" "" "114.5" "114.7" "112.9" "94.9" "96.0" "95.1" "82.3" "63.7" "97.4" "95.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3631666065222226929" "False" "High" "IsMasterProtein" "P42898" "Methylenetetrahydrofolate reductase (NADPH) OS=Homo sapiens OX=9606 GN=MTHFR PE=1 SV=3" "0.000" "False" "8.044" "4" "3" "3" "3" "656" "74.5" "5.34" "9.07" "3" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf02219" "4524" "ENSG00000177000" "MTHFR" "B2R7A6; hsa:4524; P42898; Q5SNW6; Q5SNW9; Q7Z6M6; Q8IU73; Q9UQR2" "Glycine metabolism; Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; MTHFR deficiency; Male infertility; Spina bifida" "Metabolism of folate and pterines" "14" "0" "0.678" "1.346" "0.850" "0.862" "0.972" "0.945" "1.053" "1.045" "1.091" "99.4" "67.5" "133.8" "84.5" "85.7" "96.7" "93.9" "104.7" "103.9" "108.5" "" "" "" "" "" "" "" "" "" "" "59.5" "35.1" "74.1" "39.7" "39.7" "49.5" "43.7" "47.0" "56.4" "108.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5982176321518383" "False" "High" "IsMasterProtein" "Q92572" "AP-3 complex subunit sigma-1 OS=Homo sapiens OX=9606 GN=AP3S1 PE=1 SV=1" "0.000" "False" "8.035" "13" "2" "2" "2" "193" "21.7" "5.39" "5.88" "2" "cell organization and biogenesis;transport;signal transduction" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01217" "1176" "ENSG00000177879" "AP3S1" "hsa:1176; O00647; O00676; O00721; O00727; Q53XL4; Q6ICQ2; Q92572" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "1.174" "1.316" "1.340" "1.608" "1.311" "1.281" "1.106" "1.209" "1.822" "27.7" "32.5" "36.4" "37.1" "44.5" "36.3" "35.5" "30.6" "33.5" "50.5" "" "" "" "" "" "" "" "" "" "" "16.6" "16.9" "20.2" "17.4" "20.6" "18.6" "16.5" "13.8" "18.2" "50.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8494127544242029271" "False" "High" "IsMasterProtein" "P62249" "Small ribosomal subunit protein uS9 OS=Homo sapiens OX=9606 GN=RPS16 PE=1 SV=2" "0.000" "False" "8.024" "18" "3" "7" "3" "146" "16.4" "10.21" "18.48" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00380" "6217" "ENSG00000105193" "RPS16" "B2RDD5; hsa:6217; P17008; P62249" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; SARS-CoV-1 modulates host translation machinery; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "19" "0" "1.014" "0.919" "1.020" "1.023" "0.986" "1.014" "0.897" "0.991" "1.665" "307.2" "311.6" "282.4" "313.4" "314.4" "302.8" "311.6" "275.4" "304.4" "511.3" "" "" "" "" "" "" "" "" "" "" "183.8" "161.9" "156.4" "147.1" "145.7" "155.0" "144.9" "123.6" "165.2" "511.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "556799029181218119" "False" "High" "IsMasterProtein" "Q13596" "Sorting nexin-1 OS=Homo sapiens OX=9606 GN=SNX1 PE=1 SV=3" "0.000" "False" "8.023" "8" "4" "5" "4" "522" "59.0" "5.15" "6.06" "4" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf03700, Pf09325" "6642" "ENSG00000028528" "SNX1" "A6NM19; A8K6T7; H0Y2M5; hsa:6642; O60750; O60751; Q13596; Q6ZRJ8" "" "" "0" "0" "1.359" "1.395" "1.684" "1.262" "0.642" "1.196" "1.199" "1.389" "5.101" "26.4" "35.9" "36.8" "44.5" "33.3" "17.0" "31.6" "31.6" "36.7" "134.7" "" "" "" "" "" "" "" "" "" "" "15.8" "18.6" "20.4" "20.9" "15.4" "8.7" "14.7" "14.2" "19.9" "134.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6883226900925947322" "False" "High" "IsMasterProtein" "Q9BW83" "Intraflagellar transport protein 27 homolog OS=Homo sapiens OX=9606 GN=IFT27 PE=1 SV=1" "0.000" "False" "8.016" "16" "3" "11" "3" "186" "20.5" "5.41" "24.42" "3" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00071" "11020" "ENSG00000100360" "IFT27" "hsa:11020; O60897; Q9BW83" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; GDNF/RET signaling axis; Alstrom syndrome; Bardet-Biedl syndrome" "Intraflagellar transport" "8" "0" "1.017" "0.912" "0.998" "0.886" "1.019" "0.959" "1.081" "0.896" "0.606" "289.1" "293.9" "263.6" "288.6" "256.2" "294.8" "277.3" "312.6" "259.1" "175.2" "" "" "" "" "" "" "" "" "" "" "173.0" "152.7" "146.0" "135.5" "118.8" "150.9" "128.9" "140.3" "140.6" "175.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4023730213020721894" "False" "High" "IsMasterProtein" "Q9NVX2" "Notchless protein homolog 1 OS=Homo sapiens OX=9606 GN=NLE1 PE=1 SV=4" "0.000" "False" "7.994" "7" "4" "5" "4" "485" "53.3" "7.34" "6.98" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus" "" "Pf00400, Pf08154" "54475" "ENSG00000073536" "NLE1" "hsa:54475; O60868; Q59GJ8; Q9BU54; Q9NVX2" "17q12 copy number variation syndrome" "" "1" "0" "1.019" "0.821" "0.882" "1.023" "0.919" "0.809" "0.941" "0.960" "0.708" "150.7" "153.5" "123.7" "132.9" "154.1" "138.5" "122.0" "141.8" "144.6" "106.6" "" "" "" "" "" "" "" "" "" "" "90.2" "79.8" "68.5" "62.4" "71.4" "70.9" "56.7" "63.7" "78.5" "106.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8383359941094889164" "False" "High" "IsMasterProtein" "Q9NV35" "Nucleotide triphosphate diphosphatase NUDT15 OS=Homo sapiens OX=9606 GN=NUDT15 PE=1 SV=1" "0.000" "False" "7.992" "18" "3" "3" "3" "164" "18.6" "6.14" "8.72" "3" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol" "other molecular function" "Pf00293" "55270" "ENSG00000136159" "NUDT15" "A2RUR6; hsa:55270; Q32Q27; Q6P2C9; Q9NV35" "" "Azathioprine ADME; Phosphate bond hydrolysis by NUDT proteins" "2" "0" "1.030" "1.051" "0.957" "1.064" "1.123" "0.869" "0.983" "0.983" "1.129" "459.2" "473.0" "482.4" "439.6" "488.5" "515.7" "398.9" "451.3" "451.3" "518.4" "" "" "" "" "" "" "" "" "" "" "274.8" "245.8" "267.2" "206.4" "226.4" "264.0" "185.5" "202.6" "244.8" "518.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6104369569183716546" "False" "High" "IsMasterProtein" "P36915" "Guanine nucleotide-binding protein-like 1 OS=Homo sapiens OX=9606 GN=GNL1 PE=1 SV=2" "0.000" "False" "7.985" "5" "3" "3" "3" "607" "68.6" "5.80" "5.66" "3" "stress response;signal transduction;other biological processes" "non-structural extracellular" "other molecular function" "Pf01926" "2794" "ENSG00000204590; ENSG00000206492; ENSG00000226882; ENSG00000228581; ENSG00000229470; ENSG00000232143; ENSG00000235986" "GNL1" "B0S838; hsa:2794; P36915; Q96CT5" "" "" "0" "0" "1.069" "0.964" "0.983" "0.903" "1.006" "0.826" "1.119" "1.033" "2.977" "20.8" "22.3" "20.1" "20.5" "18.8" "20.9" "17.2" "23.3" "21.5" "62.0" "" "" "" "" "" "" "" "" "" "" "12.5" "11.6" "11.1" "9.6" "8.7" "10.7" "8.0" "10.5" "11.7" "62.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4243643898250283401" "False" "High" "IsMasterProtein" "Q9UI08" "Ena/VASP-like protein OS=Homo sapiens OX=9606 GN=EVL PE=1 SV=2" "0.000" "False" "7.967" "7" "2" "2" "2" "416" "44.6" "8.84" "5.88" "2" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "51466" "ENSG00000196405" "EVL" "A8K105; B7Z3I5; hsa:51466; O95884; Q7Z522; Q8TBV1; Q9UF25; Q9UI08; Q9UIC2" "" "RHO GTPases Activate Formins; Generation of second messenger molecules; Signaling by ROBO receptors" "3" "0" "1.286" "1.868" "1.326" "1.376" "1.510" "1.419" "1.099" "1.380" "3.522" "26.1" "33.5" "48.7" "34.6" "35.9" "39.4" "37.0" "28.7" "36.0" "91.9" "" "" "" "" "" "" "" "" "" "" "15.6" "17.4" "27.0" "16.2" "16.6" "20.2" "17.2" "12.9" "19.5" "91.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4446297038364687966" "False" "High" "IsMasterProtein" "Q9NPA8" "Transcription and mRNA export factor ENY2 OS=Homo sapiens OX=9606 GN=ENY2 PE=1 SV=1" "0.000" "False" "7.962" "41" "4" "9" "4" "101" "11.5" "9.33" "16.30" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf10163" "56943" "ENSG00000120533" "ENY2" "B2RE52; G3V117; hsa:56943; Q9NPA8" "" "HATs acetylate histones" "1" "0" "1.098" "0.985" "1.032" "1.029" "1.053" "1.144" "1.066" "1.080" "0.693" "409.9" "450.0" "403.8" "423.2" "421.7" "431.7" "468.9" "437.0" "442.8" "284.0" "" "" "" "" "" "" "" "" "" "" "245.3" "233.8" "223.6" "198.7" "195.5" "221.0" "218.0" "196.2" "240.2" "284.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3522483334195236405" "False" "High" "IsMasterProtein" "Q13542" "Eukaryotic translation initiation factor 4E-binding protein 2 OS=Homo sapiens OX=9606 GN=EIF4EBP2 PE=1 SV=1" "0.000" "False" "7.960" "23" "2" "4" "2" "120" "12.9" "6.67" "11.25" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05456" "1979" "ENSG00000148730" "EIF4EBP2" "hsa:1979; Q13542" "Translation factors; Fragile X syndrome" "" "2" "0" "1.151" "0.919" "1.261" "1.056" "0.916" "1.162" "1.275" "0.943" "0.648" "74.3" "85.5" "68.3" "93.7" "78.4" "68.1" "86.4" "94.7" "70.1" "48.2" "" "" "" "" "" "" "" "" "" "" "44.5" "44.4" "37.8" "44.0" "36.4" "34.8" "40.2" "42.5" "38.0" "48.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8640947955125983665" "False" "High" "IsMasterProtein" "Q9Y5A7" "NEDD8 ultimate buster 1 OS=Homo sapiens OX=9606 GN=NUB1 PE=1 SV=2" "0.000" "False" "7.945" "3" "2" "2" "2" "615" "70.5" "5.96" "7.62" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "" "Pf00627, Pf18037" "51667" "ENSG00000013374" "NUB1" "hsa:51667; O95422; Q75MR9; Q8IX22; Q9BXR2; Q9Y5A7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5771737938610614120" "False" "High" "IsMasterProtein" "Q9UPN7" "Serine/threonine-protein phosphatase 6 regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PPP6R1 PE=1 SV=5" "0.000" "False" "7.941" "6" "4" "4" "4" "881" "96.7" "4.55" "4.59" "4" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf04499" "22870" "ENSG00000105063" "PPP6R1" "hsa:22870; Q2M2H3; Q504V2; Q6NVJ6; Q9BU97; Q9UPN7" "" "COPII-mediated vesicle transport" "1" "0" "1.078" "1.180" "0.886" "1.164" "1.052" "1.268" "1.055" "1.122" "2.155" "38.3" "41.3" "45.2" "33.9" "44.6" "40.3" "48.6" "40.4" "43.0" "82.6" "" "" "" "" "" "" "" "" "" "" "22.9" "21.5" "25.0" "15.9" "20.7" "20.6" "22.6" "18.1" "23.3" "82.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-77584884133553683" "False" "High" "IsMasterProtein" "Q9UMY4" "Sorting nexin-12 OS=Homo sapiens OX=9606 GN=SNX12 PE=1 SV=4" "0.000" "False" "7.937" "20" "3" "3" "2" "162" "18.9" "8.44" "7.72" "3" "transport;other biological processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00787" "29934" "ENSG00000147164" "SNX12" "F8W8K5; hsa:29934; Q8WUG9; Q9UMY4" "" "" "0" "0" "0.980" "1.085" "1.132" "1.213" "0.899" "1.112" "0.996" "0.959" "1.697" "64.6" "63.3" "70.1" "73.2" "78.4" "58.1" "71.9" "64.4" "62.0" "109.7" "" "" "" "" "" "" "" "" "" "" "38.7" "32.9" "38.8" "34.3" "36.3" "29.8" "33.4" "28.9" "33.6" "109.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8775009623055408679" "False" "High" "IsMasterProtein" "Q5BKY9" "Protein FAM133B OS=Homo sapiens OX=9606 GN=FAM133B PE=1 SV=1" "0.000" "False" "7.934" "10" "2" "3" "2" "247" "28.4" "10.02" "6.75" "2" "" "" "" "" "257415" "ENSG00000234545" "FAM133B" "B2R994; hsa:257415; Q05D67; Q5BKY9; Q6P5S6; Q8N0W8" "" "" "0" "0" "1.269" "1.127" "0.989" "0.962" "1.163" "0.972" "1.063" "1.081" "0.549" "66.8" "84.8" "75.2" "66.0" "64.2" "77.7" "64.9" "71.0" "72.2" "36.7" "" "" "" "" "" "" "" "" "" "" "40.0" "44.1" "41.7" "31.0" "29.8" "39.8" "30.2" "31.9" "39.2" "36.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "295082137940750650" "False" "High" "IsMasterProtein" "O43633" "Charged multivesicular body protein 2a OS=Homo sapiens OX=9606 GN=CHMP2A PE=1 SV=1" "0.000" "False" "7.930" "12" "3" "3" "3" "222" "25.1" "5.97" "6.60" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "27243" "ENSG00000130724" "CHMP2A" "B2R4W6; hsa:27243; O43633; Q3ZTT0" "" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Lysosome Vesicle Biogenesis; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "10" "0" "1.130" "1.021" "1.083" "1.149" "1.137" "1.163" "1.122" "1.088" "0.760" "259.3" "293.0" "264.8" "280.7" "297.9" "294.8" "301.6" "290.8" "282.1" "197.0" "" "" "" "" "" "" "" "" "" "" "155.2" "152.3" "146.6" "131.8" "138.1" "150.9" "140.3" "130.5" "153.0" "197.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4306036841848923980" "False" "High" "IsMasterProtein" "Q08752" "Peptidyl-prolyl cis-trans isomerase D OS=Homo sapiens OX=9606 GN=PPID PE=1 SV=3" "0.000" "False" "7.928" "7" "3" "5" "3" "370" "40.7" "7.21" "8.71" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00160" "5481" "ENSG00000171497" "PPID" "B2R9V2; hsa:5481; Q08752" "Alzheimer's disease and miRNA effects; NO/cGMP/PKG mediated neuroprotection; Alzheimer's disease" "ESR-mediated signaling" "4" "0" "0.751" "1.423" "1.448" "1.712" "1.229" "1.647" "0.589" "1.187" "8.890" "9.4" "7.1" "13.4" "13.6" "16.1" "11.6" "15.5" "5.5" "11.2" "83.7" "" "" "" "" "" "" "" "" "" "" "5.6" "3.7" "7.4" "6.4" "7.5" "5.9" "7.2" "2.5" "6.1" "83.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1594484432885072185" "False" "High" "IsMasterProtein" "O75663" "TIP41-like protein OS=Homo sapiens OX=9606 GN=TIPRL PE=1 SV=2" "0.000" "False" "7.925" "12" "3" "3" "3" "272" "31.4" "5.91" "5.02" "3" "stress response;signal transduction;other biological processes" "cytosol" "" "Pf04176" "261726" "ENSG00000143155" "TIPRL" "B2R8V3; hsa:261726; O75663; Q5HYB2; Q8IZ86" "Ciliary landscape" "" "1" "0" "1.047" "1.537" "1.052" "1.364" "1.111" "1.242" "0.544" "1.158" "4.120" "67.8" "71.0" "104.3" "71.4" "92.5" "75.4" "84.2" "36.9" "78.5" "279.5" "" "" "" "" "" "" "" "" "" "" "40.6" "36.9" "57.7" "33.5" "42.9" "38.6" "39.2" "16.6" "42.6" "279.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8360736340109521171" "False" "High" "IsMasterProtein" "P57737" "Coronin-7 OS=Homo sapiens OX=9606 GN=CORO7 PE=1 SV=2" "0.000" "False" "7.916" "3" "3" "4" "3" "925" "100.5" "5.80" "7.68" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "cytoskeletal activity" "Pf00400, Pf08953, Pf16300" "79585" "ENSG00000262246; ENSG00000282725" "CORO7" "B4DFD6; B4DL18; hsa:79585; I3L416; P57737; Q17RK4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3544092344489090561" "False" "High" "IsMasterProtein" "Q8TB72" "Pumilio homolog 2 OS=Homo sapiens OX=9606 GN=PUM2 PE=1 SV=2" "0.000" "False" "7.915" "3" "3" "3" "3" "1066" "114.1" "7.08" "7.88" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00806" "23369" "ENSG00000055917" "PUM2" "B3KSL0; B4E2B6; D6W527; hsa:23369; O00234; Q53TV7; Q8TB72; Q8WY43; Q9HAN2" "Male infertility" "Neddylation" "2" "0" "1.194" "1.171" "1.036" "1.207" "1.347" "1.211" "1.114" "1.227" "2.633" "131.2" "156.6" "153.7" "135.9" "158.4" "176.7" "159.0" "146.2" "161.0" "345.6" "" "" "" "" "" "" "" "" "" "" "78.5" "81.4" "85.1" "63.8" "73.4" "90.5" "73.9" "65.6" "87.3" "345.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5370481134034691073" "False" "High" "IsMasterProtein" "P22307" "Sterol carrier protein 2 OS=Homo sapiens OX=9606 GN=SCP2 PE=1 SV=2" "0.000" "False" "7.877" "4" "2" "3" "2" "547" "59.0" "6.89" "10.74" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00108, Pf02036, Pf02803" "6342" "ENSG00000116171" "SCP2" "A6NM69; B4DGJ9; B4DHP6; C9JC79; D3DQ37; E1B6W5; F2Z3J1; hsa:6342; P22307; Q15432; Q16622; Q5VVZ1; Q6NXF4; Q99430" "PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Mitochondrial fatty acid oxidation disorders; DNA damage response (only ATM dependent)" "TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism" "10" "0" "0.948" "0.822" "0.935" "1.096" "1.043" "1.141" "1.119" "1.128" "0.525" "289.0" "273.9" "237.5" "270.3" "316.8" "301.5" "329.7" "323.5" "326.1" "151.8" "" "" "" "" "" "" "" "" "" "" "173.0" "142.3" "131.5" "126.9" "146.8" "154.3" "153.3" "145.2" "176.9" "151.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4890762250346228692" "False" "High" "IsMasterProtein" "P35250" "Replication factor C subunit 2 OS=Homo sapiens OX=9606 GN=RFC2 PE=1 SV=3" "0.000" "False" "7.876" "9" "3" "3" "3" "354" "39.1" "6.44" "5.58" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5982" "ENSG00000049541" "RFC2" "B5BU07; D3DXG3; hsa:5982; P32846; P35250; Q9BU93" "DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; HDR through Homologous Recombination (HRR); Termination of translesion DNA synthesis; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "27" "0" "1.765" "1.369" "2.112" "2.476" "2.218" "1.994" "0.936" "2.130" "6.436" "8.5" "15.0" "11.7" "18.0" "21.1" "18.9" "17.0" "8.0" "18.2" "54.8" "" "" "" "" "" "" "" "" "" "" "5.1" "7.8" "6.5" "8.4" "9.8" "9.7" "7.9" "3.6" "9.8" "54.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8494300980345175756" "False" "High" "IsMasterProtein" "P48059" "LIM and senescent cell antigen-like-containing domain protein 1 OS=Homo sapiens OX=9606 GN=LIMS1 PE=1 SV=4" "0.000" "False" "7.873" "6" "2" "3" "2" "325" "37.2" "8.05" "5.20" "2" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00412" "3987" "ENSG00000169756" "LIMS1" "B2RAJ4; B7Z483; B7Z7R3; B7Z907; hsa:3987; P48059; Q53TE0; Q9BS44" "Primary focal segmental glomerulosclerosis (FSGS)" "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "3" "0" "1.101" "1.018" "1.144" "1.137" "1.066" "1.067" "1.079" "1.061" "0.681" "357.6" "393.6" "363.9" "409.0" "406.6" "381.2" "381.6" "385.7" "379.5" "243.3" "" "" "" "" "" "" "" "" "" "" "214.0" "204.5" "201.5" "192.0" "188.5" "195.2" "177.5" "173.2" "205.9" "243.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4884717818161655002" "False" "High" "IsMasterProtein" "Q9H4L5" "Oxysterol-binding protein-related protein 3 OS=Homo sapiens OX=9606 GN=OSBPL3 PE=1 SV=1" "0.000" "False" "7.871" "4" "3" "3" "3" "887" "101.2" "6.87" "7.20" "3" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf01237, Pf15409" "26031" "ENSG00000070882" "OSBPL3" "A4D167; A4D168; A4D169; A4D170; A4D171; A4D172; B8ZZ79; B8ZZP0; hsa:26031; O14591; O43357; O43358; Q8N702; Q8N703; Q8N704; Q8NFH0; Q8NFH1; Q8NI12; Q8NI13; Q9BZF4; Q9H4L5; Q9UED6" "Orexin receptor pathway" "Synthesis of bile acids and bile salts" "2" "0" "0.914" "1.045" "0.976" "0.928" "1.033" "0.943" "1.139" "0.980" "1.413" "215.5" "196.8" "225.3" "210.3" "199.9" "222.6" "203.2" "245.5" "211.2" "304.5" "" "" "" "" "" "" "" "" "" "" "128.9" "102.3" "124.7" "98.7" "92.6" "113.9" "94.5" "110.2" "114.6" "304.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6538585977691412019" "False" "High" "IsMasterProtein" "Q9BYB4" "Guanine nucleotide-binding protein subunit beta-like protein 1 OS=Homo sapiens OX=9606 GN=GNB1L PE=1 SV=2" "0.000" "False" "7.865" "6" "2" "5" "2" "327" "35.6" "7.97" "15.59" "2" "" "" "" "Pf00400" "54584" "ENSG00000185838" "GNB1L" "hsa:54584; Q9BYB4; Q9H2S2; Q9H4M4" "22q11.2 copy number variation syndrome" "" "1" "0" "0.947" "0.975" "1.106" "0.953" "1.067" "1.010" "0.999" "0.923" "0.723" "451.3" "427.3" "439.9" "499.3" "430.3" "481.5" "455.6" "450.7" "416.6" "326.3" "" "" "" "" "" "" "" "" "" "" "270.1" "222.0" "243.6" "234.4" "199.5" "246.5" "211.9" "202.4" "226.0" "326.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1683899515612259900" "False" "High" "IsMasterProtein" "O94776" "Metastasis-associated protein MTA2 OS=Homo sapiens OX=9606 GN=MTA2 PE=1 SV=1" "0.000" "False" "7.858" "5" "3" "3" "1" "668" "75.0" "9.66" "5.11" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "9219" "ENSG00000149480" "MTA2" "hsa:9219; O94776; Q68DB1; Q9UQB5" "Effect of progerin on genes involved in progeria" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3028893805167112372" "False" "High" "IsMasterProtein" "O75351" "Vacuolar protein sorting-associated protein 4B OS=Homo sapiens OX=9606 GN=VPS4B PE=1 SV=2" "0.000" "False" "7.853" "8" "4" "4" "2" "444" "49.3" "7.23" "8.22" "4" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00004, Pf04212, Pf09336, Pf17862" "9525" "ENSG00000119541" "VPS4B" "hsa:9525; O75351; Q69HW4; Q9GZS7" "" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "2" "0" "1.283" "0.607" "1.032" "1.121" "0.872" "1.184" "0.533" "0.858" "3.510" "19.1" "24.5" "11.6" "19.7" "21.4" "16.7" "22.6" "10.2" "16.4" "67.0" "" "" "" "" "" "" "" "" "" "" "11.4" "12.7" "6.4" "9.3" "9.9" "8.5" "10.5" "4.6" "8.9" "67.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-843135532772952093" "False" "High" "IsMasterProtein" "Q8TD55" "Pleckstrin homology domain-containing family O member 2 OS=Homo sapiens OX=9606 GN=PLEKHO2 PE=1 SV=1" "0.000" "False" "7.851" "7" "3" "3" "3" "490" "53.3" "5.43" "3.09" "3" "other biological processes" "non-structural extracellular;other cell component" "" "Pf00169" "80301" "ENSG00000241839" "PLEKHO2" "hsa:80301; Q7L4H4; Q8TD55; Q8WYS8" "" "Neutrophil degranulation" "1" "0" "1.329" "1.234" "1.592" "1.275" "1.134" "1.401" "1.404" "1.303" "1.365" "64.5" "85.8" "79.6" "102.7" "82.3" "73.1" "90.4" "90.6" "84.1" "88.1" "" "" "" "" "" "" "" "" "" "" "38.6" "44.6" "44.1" "48.2" "38.1" "37.4" "42.0" "40.7" "45.6" "88.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3647581331953333811" "False" "High" "IsMasterProtein" "Q658Y4" "Protein FAM91A1 OS=Homo sapiens OX=9606 GN=FAM91A1 PE=1 SV=3" "0.000" "False" "7.850" "2" "2" "4" "2" "838" "93.9" "6.39" "7.17" "2" "cell organization and biogenesis;transport" "ER/Golgi;other cell component" "" "Pf14647, Pf14648" "157769" "ENSG00000176853" "FAM91A1" "B6YY23; hsa:157769; Q658T5; Q658Y4; Q8TE89" "Gastric cancer network 2" "RHOH GTPase cycle" "2" "0" "1.155" "0.527" "0.759" "1.328" "0.779" "0.852" "1.220" "0.707" "1.297" "21.5" "24.8" "11.3" "16.3" "28.5" "16.7" "18.3" "26.2" "15.2" "27.8" "" "" "" "" "" "" "" "" "" "" "12.8" "12.9" "6.3" "7.6" "13.2" "8.6" "8.5" "11.7" "8.2" "27.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6816418598839755867" "False" "High" "IsMasterProtein" "Q9NXC5" "GATOR2 complex protein MIOS OS=Homo sapiens OX=9606 GN=MIOS PE=1 SV=2" "0.000" "False" "7.850" "4" "3" "4" "3" "875" "98.5" "6.73" "10.51" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf17034, Pf21719, Pf21720" "54468" "ENSG00000164654" "MIOS" "B2RTV6; hsa:54468; O75216; Q7L551; Q9H092; Q9NXC5" "" "Amino acids regulate mTORC1" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1430598846084428850" "False" "High" "IsMasterProtein" "Q3B726" "DNA-directed RNA polymerase I subunit RPA43 OS=Homo sapiens OX=9606 GN=POLR1F PE=1 SV=1" "0.000" "False" "7.844" "10" "2" "2" "2" "338" "37.4" "6.98" "5.55" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf03876, Pf17875" "221830" "ENSG00000105849" "POLR1F" "A0PJ45; B7Z724; hsa:221830; Q3B726" "Pyrimidine metabolism; 2q13 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3949096695489977400" "False" "High" "IsMasterProtein" "P05386" "Large ribosomal subunit protein P1 OS=Homo sapiens OX=9606 GN=RPLP1 PE=1 SV=1" "0.000" "False" "7.835" "20" "3" "8" "1" "114" "11.5" "4.32" "15.54" "3" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "enzyme regulator activity;other molecular function" "Pf00428" "6176" "ENSG00000137818" "RPLP1" "A6NIB2; hsa:6176; P05386" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.018" "0.925" "0.950" "1.194" "1.104" "1.260" "1.095" "1.143" "0.718" "209.8" "213.5" "194.1" "199.4" "250.5" "231.6" "264.3" "229.6" "239.7" "150.6" "" "" "" "" "" "" "" "" "" "" "125.5" "110.9" "107.5" "93.6" "116.1" "118.5" "122.9" "103.1" "130.1" "150.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7123841880797263349" "False" "High" "IsMasterProtein" "P09382" "Galectin-1 OS=Homo sapiens OX=9606 GN=LGALS1 PE=1 SV=2" "0.000" "False" "7.824" "19" "3" "5" "3" "135" "14.7" "5.50" "9.66" "3" "cell adhesion;other biological processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00337" "3956" "ENSG00000100097" "LGALS1" "B2R5E8; hsa:3956; P09382; Q9UDK5" "Immune infiltration in pancreatic cancer" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "316205606070741097" "False" "High" "IsMasterProtein" "Q5JTD0" "Tight junction-associated protein 1 OS=Homo sapiens OX=9606 GN=TJAP1 PE=1 SV=1" "0.000" "False" "7.823" "7" "3" "3" "3" "557" "61.8" "5.97" "4.22" "3" "cell organization and biogenesis" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf15453" "93643" "ENSG00000137221" "TJAP1" "hsa:93643; Q05BH9; Q5JTD0; Q5JTD1; Q5JWW1; Q68DB2; Q6P2P3; Q9H7V7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5940813161561783541" "False" "High" "IsMasterProtein" "Q9H078" "Mitochondrial disaggregase OS=Homo sapiens OX=9606 GN=CLPB PE=1 SV=1" "0.000" "False" "7.821" "3" "2" "3" "2" "707" "78.7" "9.01" "8.91" "2" "stress response;signal transduction;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf07724, Pf10431, Pf12796" "81570" "ENSG00000162129" "CLPB" "B4DXJ7; B4DXP7; B4DXW4; E7EWN6; F8W7P6; hsa:81570; Q8ND11; Q9H078; Q9H8Y0" "" "" "0" "0" "1.114" "1.054" "1.140" "1.324" "0.968" "1.083" "1.481" "1.157" "1.489" "37.5" "41.8" "39.5" "42.8" "49.7" "36.3" "40.6" "55.6" "43.4" "55.9" "" "" "" "" "" "" "" "" "" "" "22.5" "21.7" "21.9" "20.1" "23.0" "18.6" "18.9" "24.9" "23.5" "55.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2260804329009372873" "False" "High" "IsMasterProtein" "Q13045" "Protein flightless-1 homolog OS=Homo sapiens OX=9606 GN=FLII PE=1 SV=2" "0.000" "False" "7.816" "3" "4" "4" "4" "1269" "144.7" "6.05" "8.46" "4" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00560, Pf00626, Pf12799, Pf13855" "2314" "ENSG00000177731; ENSG00000284571" "FLII" "B4DIL0; F5H407; hsa:2314; J3QLG3; Q13045" "VEGFA-VEGFR2 signaling; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2503112779916804665" "False" "High" "IsMasterProtein" "Q8WV28" "B-cell linker protein OS=Homo sapiens OX=9606 GN=BLNK PE=1 SV=2" "0.000" "False" "7.805" "5" "3" "4" "3" "456" "50.4" "8.16" "7.84" "3" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017" "29760" "ENSG00000095585" "BLNK" "hsa:29760; O75498; O75499; Q2MD49; Q8WV28" "B cell receptor signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "Regulation of signaling by CBL; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "5" "0" "1.056" "0.953" "0.876" "1.036" "0.973" "0.920" "0.873" "0.935" "0.738" "212.4" "224.3" "202.3" "186.0" "220.0" "206.6" "195.3" "185.4" "198.6" "156.9" "" "" "" "" "" "" "" "" "" "" "127.1" "116.6" "112.1" "87.3" "102.0" "105.8" "90.8" "83.2" "107.7" "156.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6888861531159930886" "False" "High" "IsMasterProtein" "Q9H832" "Ubiquitin-conjugating enzyme E2 Z OS=Homo sapiens OX=9606 GN=UBE2Z PE=1 SV=2" "0.000" "False" "7.782" "7" "1" "1" "1" "354" "38.2" "5.62" "5.58" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf00179" "65264" "ENSG00000159202" "UBE2Z" "A6N8M6; A6NC60; hsa:65264; Q7L354; Q8TCM4; Q9H832; Q9H893" "" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "Not Found" "Not Found" "Not Found" "High" "1" "" "-5991678768207076864" "False" "High" "IsMasterProtein" "Q9UNF1" "Melanoma-associated antigen D2 OS=Homo sapiens OX=9606 GN=MAGED2 PE=1 SV=2" "0.000" "False" "7.754" "5" "2" "2" "2" "606" "64.9" "9.32" "3.88" "2" "transport;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01454" "10916" "ENSG00000102316" "MAGED2" "A6NMX0; hsa:10916; O76058; Q5BJF3; Q8NAL6; Q9H218; Q9P0U9; Q9UM52; Q9UNF1" "" "Platelet degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2730791661393038830" "False" "High" "IsMasterProtein" "Q9Y3P8" "Signaling threshold-regulating transmembrane adapter 1 OS=Homo sapiens OX=9606 GN=SIT1 PE=1 SV=1" "0.000" "False" "7.749" "18" "2" "2" "2" "196" "21.1" "6.30" "5.27" "2" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "" "27240" "ENSG00000137078" "SIT1" "B2RBP9; hsa:27240; Q9Y3P8" "" "" "0" "0" "1.186" "1.094" "1.259" "1.846" "1.155" "1.199" "1.352" "1.234" "0.698" "30.0" "35.6" "32.8" "37.8" "55.4" "34.7" "36.0" "40.6" "37.0" "21.0" "" "" "" "" "" "" "" "" "" "" "18.0" "18.5" "18.2" "17.7" "25.7" "17.7" "16.7" "18.2" "20.1" "21.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5750940690254382676" "False" "High" "IsMasterProtein" "P16333" "SH2/SH3 adapter protein NCK1 OS=Homo sapiens OX=9606 GN=NCK1 PE=1 SV=1" "0.000" "False" "7.720" "8" "3" "5" "3" "377" "42.8" "6.47" "5.48" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018" "4690" "ENSG00000158092" "NCK1" "B7Z751; D3DNE3; hsa:4690; P16333" "Pathogenic Escherichia coli infection; B cell receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway; Genes controlling nephrogenesis; GDNF signaling; ErbB signaling pathway; T-cell receptor signaling pathway" "Potential therapeutics for SARS; VEGFA-VEGFR2 Pathway; Generation of second messenger molecules; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; RHO GTPases Activate WASPs and WAVEs; PKR-mediated signaling; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; DCC mediated attractive signaling; Downstream signal transduction; Activation of RAC1" "27" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-296072814185556824" "False" "High" "IsMasterProtein" "Q9BUI4" "DNA-directed RNA polymerase III subunit RPC3 OS=Homo sapiens OX=9606 GN=POLR3C PE=1 SV=1" "0.000" "False" "7.713" "5" "3" "3" "3" "534" "60.6" "7.31" "7.32" "3" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05645, Pf08221, Pf20912" "10623" "ENSG00000186141" "POLR3C" "hsa:10623; O15317; Q9BUI4; Q9Y3R6" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; TAR syndrome" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "0.856" "0.913" "0.989" "0.943" "1.204" "0.972" "0.658" "0.893" "1.217" "106.5" "91.2" "97.3" "105.4" "100.5" "128.3" "103.6" "70.1" "95.2" "129.7" "" "" "" "" "" "" "" "" "" "" "63.8" "47.4" "53.9" "49.5" "46.6" "65.7" "48.2" "31.5" "51.6" "129.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5768546020460865093" "False" "High" "IsMasterProtein" "O15160" "DNA-directed RNA polymerases I and III subunit RPAC1 OS=Homo sapiens OX=9606 GN=POLR1C PE=1 SV=1" "0.000" "False" "7.710" "10" "3" "5" "3" "346" "39.2" "5.50" "1.91" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01000, Pf01193" "9533" "ENSG00000171453" "POLR1C" "hsa:9533; O15160; O75395; Q5JTE3" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9069432479560653681" "False" "High" "IsMasterProtein" "Q08AM6" "Protein VAC14 homolog OS=Homo sapiens OX=9606 GN=VAC14 PE=1 SV=1" "0.000" "False" "7.699" "4" "3" "3" "3" "782" "87.9" "6.13" "4.82" "3" "other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf11916, Pf12755" "55697" "ENSG00000103043" "VAC14" "B3KPJ5; B3KSM8; hsa:55697; Q08AM6; Q13174; Q6IA12; Q7L4Y1; Q9BW96; Q9H6V6" "" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1466786555444396810" "False" "High" "IsMasterProtein" "Q12933" "TNF receptor-associated factor 2 OS=Homo sapiens OX=9606 GN=TRAF2 PE=1 SV=2" "0.000" "False" "7.697" "5" "3" "4" "3" "501" "55.8" "7.53" "5.36" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00097, Pf02176, Pf16673, Pf21341, Pf21355" "7186" "ENSG00000127191" "TRAF2" "A8K107; B4DPJ7; hsa:7186; Q12933; Q7Z337; Q96NT2" "RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Apoptosis; Photodynamic therapy-induced AP-1 survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Oxidative damage response; p38 MAPK signaling pathway; Nonalcoholic fatty liver disease; Small cell lung cancer; 16p11.2 proximal deletion syndrome; 16p11.2 distal deletion syndrome; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Pleural mesothelioma; Alzheimer's disease; 1p36 copy number variation syndrome; 13q12.12 copy number variation; 8q11.23 (RB1CC1) copy number variation" "Ub-specific processing proteases; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TRAF6 mediated NF-kB activation; Regulation of NF-kappa B signaling; TNFR1-induced proapoptotic signaling; TRAF6 mediated IRF7 activation; Defective RIPK1-mediated regulated necrosis" "37" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7779362395337591117" "False" "High" "IsMasterProtein" "Q96FX7" "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Homo sapiens OX=9606 GN=TRMT61A PE=1 SV=1" "0.000" "False" "7.692" "11" "3" "4" "3" "289" "31.4" "7.36" "10.66" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf08704" "115708" "ENSG00000166166" "TRMT61A" "A6NN78; hsa:115708; Q8N7Q9; Q96FX7" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.914" "0.891" "1.050" "0.826" "0.913" "0.974" "0.862" "1.020" "0.545" "247.0" "225.7" "220.1" "259.3" "204.1" "225.4" "240.7" "213.0" "251.9" "134.7" "" "" "" "" "" "" "" "" "" "" "147.8" "117.3" "121.9" "121.7" "94.6" "115.4" "111.9" "95.6" "136.7" "134.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7071014728097244949" "False" "High" "IsMasterProtein" "Q9BW27" "Nuclear pore complex protein Nup85 OS=Homo sapiens OX=9606 GN=NUP85 PE=1 SV=1" "0.000" "False" "7.675" "4" "2" "2" "2" "656" "75.0" "5.55" "5.78" "2" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07575" "79902" "ENSG00000125450" "NUP85" "B4DMQ3; B4DPW1; hsa:79902; Q8NDI4; Q9BW27; Q9H9U1" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; SARS-CoV-2 activates/modulates innate and adaptive immune responses; tRNA processing in the nucleus; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation" "35" "0" "0.998" "0.906" "1.395" "0.893" "0.952" "1.085" "0.956" "0.963" "0.801" "92.0" "91.9" "83.3" "128.4" "82.1" "87.6" "99.8" "88.0" "88.6" "73.7" "" "" "" "" "" "" "" "" "" "" "55.1" "47.7" "46.1" "60.3" "38.1" "44.8" "46.4" "39.5" "48.1" "73.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3443446084982214279" "False" "High" "IsMasterProtein" "Q9UN37" "Vacuolar protein sorting-associated protein 4A OS=Homo sapiens OX=9606 GN=VPS4A PE=1 SV=1" "0.000" "False" "7.652" "7" "4" "4" "2" "437" "48.9" "7.80" "10.35" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00004, Pf04212, Pf09336, Pf17862" "27183" "ENSG00000132612" "VPS4A" "B2RCB7; hsa:27183; Q8TF07; Q9UI03; Q9UN37; Q9Y582" "Ebola virus infection in host; Ciliary landscape" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III" "6" "1" "1.175" "1.040" "1.316" "1.362" "1.361" "1.464" "0.849" "1.251" "5.907" "55.4" "65.1" "57.6" "72.9" "75.4" "75.4" "81.1" "47.0" "69.3" "327.3" "" "" "" "" "" "" "" "" "" "" "33.2" "33.8" "31.9" "34.2" "35.0" "38.6" "37.7" "21.1" "37.6" "327.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8782574511401724651" "False" "High" "IsMasterProtein" "Q06124" "Tyrosine-protein phosphatase non-receptor type 11 OS=Homo sapiens OX=9606 GN=PTPN11 PE=1 SV=3" "0.000" "False" "7.651" "4" "3" "4" "3" "593" "68.0" "7.30" "11.52" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00102" "5781" "ENSG00000179295" "PTPN11" "A8K1D9; hsa:5781; Q06124; Q96HD7" "IL-5 signaling pathway; Heart development; IL-1 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Pilocytic astrocytoma; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; Embryonic stem cell pluripotency pathways; IL-4 signaling pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Cancer immunotherapy by CTLA4 blockade; Cancer immunotherapy by PD-1 blockade; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; Insulin signaling; IL-2 signaling pathway; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Orexin receptor pathway; GDNF signaling; Interferon type I signaling pathways; Type II interferon signaling; T-cell receptor signaling pathway" "PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Platelet sensitization by LDL; CTLA4 inhibitory signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interleukin-3, Interleukin-5 and GM-CSF signaling; PD-1 signaling; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Signal regulatory protein family interactions; RET signaling; PI3K Cascade; GPVI-mediated activation cascade; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Signaling by CSF3 (G-CSF); GAB1 signalosome; Signaling by CSF1 (M-CSF) in myeloid cells; PI-3K cascade:FGFR1; FRS-mediated FGFR1 signaling; PI-3K cascade:FGFR2; FRS-mediated FGFR2 signaling; FRS-mediated FGFR3 signaling; PI-3K cascade:FGFR3; FRS-mediated FGFR4 signaling; PI-3K cascade:FGFR4; Activated NTRK2 signals through FRS2 and FRS3; Spry regulation of FGF signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; Interleukin-20 family signaling; Netrin mediated repulsion signals; Interleukin-37 signaling; Signaling by FLT3 ITD and TKD mutants; PECAM1 interactions; MET activates PTPN11; STAT5 activation downstream of FLT3 ITD mutants; Regulation of RUNX1 Expression and Activity; STAT5 Activation" "91" "0" "1.112" "1.126" "1.129" "1.121" "1.019" "1.068" "0.921" "1.019" "1.505" "272.3" "302.8" "306.6" "307.5" "305.1" "277.4" "290.8" "250.6" "277.3" "409.8" "" "" "" "" "" "" "" "" "" "" "162.9" "157.4" "169.8" "144.4" "141.4" "142.0" "135.2" "112.5" "150.4" "409.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6469801124856573436" "False" "High" "IsMasterProtein" "P36404" "ADP-ribosylation factor-like protein 2 OS=Homo sapiens OX=9606 GN=ARL2 PE=1 SV=4" "0.000" "False" "7.646" "10" "2" "3" "2" "184" "20.9" "6.34" "8.39" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00025" "402" "ENSG00000213465" "ARL2" "G3V184; hsa:402; P36404; Q9BUK8" "Joubert syndrome" "Post-chaperonin tubulin folding pathway; Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; RAS processing" "4" "0" "0.980" "0.929" "1.038" "0.944" "1.052" "1.248" "1.071" "1.049" "0.979" "155.5" "152.3" "144.4" "161.4" "146.8" "163.5" "194.0" "166.4" "163.1" "152.1" "" "" "" "" "" "" "" "" "" "" "93.0" "79.1" "79.9" "75.8" "68.0" "83.7" "90.2" "74.7" "88.5" "152.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3901597498303011274" "False" "High" "IsMasterProtein" "P14621" "Acylphosphatase-2 OS=Homo sapiens OX=9606 GN=ACYP2 PE=1 SV=2" "0.000" "False" "7.637" "23" "3" "3" "3" "99" "11.1" "9.50" "9.29" "3" "other metabolic processes" "" "other molecular function" "Pf00708" "98" "ENSG00000170634" "ACYP2" "hsa:98; P14621" "" "" "0" "0" "0.952" "1.018" "1.008" "1.025" "0.989" "1.051" "1.028" "0.879" "0.597" "669.3" "637.1" "681.2" "674.8" "685.8" "661.8" "703.1" "688.1" "588.2" "399.5" "" "" "" "" "" "" "" "" "" "" "400.6" "331.1" "377.2" "316.8" "317.9" "338.8" "326.9" "308.9" "319.1" "399.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5279606303405418158" "False" "High" "IsMasterProtein" "Q9H2K8" "Serine/threonine-protein kinase TAO3 OS=Homo sapiens OX=9606 GN=TAOK3 PE=1 SV=2" "0.000" "False" "7.632" "3" "3" "3" "3" "898" "105.3" "7.30" "4.85" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "51347" "ENSG00000135090" "TAOK3" "hsa:51347; Q658N1; Q8IUM4; Q9H2K8; Q9HC79; Q9NZM9; Q9UHG7" "MAPK signaling pathway" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle" "4" "0" "1.159" "1.089" "1.042" "1.125" "1.137" "1.209" "0.914" "1.189" "3.256" "96.4" "111.7" "105.0" "100.4" "108.4" "109.7" "116.6" "88.1" "114.6" "314.0" "" "" "" "" "" "" "" "" "" "" "57.7" "58.1" "58.1" "47.2" "50.3" "56.1" "54.2" "39.6" "62.2" "314.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1396372760161625634" "False" "High" "IsMasterProtein" "Q8N129" "Protein canopy homolog 4 OS=Homo sapiens OX=9606 GN=CNPY4 PE=1 SV=1" "0.000" "False" "7.622" "8" "1" "1" "1" "248" "28.3" "4.64" "4.52" "1" "other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding" "Pf11938" "245812" "ENSG00000166997" "CNPY4" "hsa:245812; Q8N129; Q8WUN9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1641780535886565556" "False" "High" "IsMasterProtein" "Q7L1T6" "Cytochrome b5 reductase 4 OS=Homo sapiens OX=9606 GN=CYB5R4 PE=1 SV=1" "0.000" "False" "7.599" "5" "2" "2" "2" "521" "59.4" "7.72" "6.80" "2" "cell-cell signaling;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00173, Pf00175, Pf00970, Pf04969" "51167" "ENSG00000065615" "CYB5R4" "B1AEM2; hsa:51167; Q5TGI9; Q7L1T6; Q9NUE4; Q9UHI9" "Oxidation by cytochrome P450" "Erythrocytes take up carbon dioxide and release oxygen" "2" "0" "1.096" "1.035" "1.373" "1.046" "1.080" "1.070" "0.883" "2.462" "1.049" "104.2" "114.2" "107.9" "143.1" "109.0" "112.5" "111.5" "92.0" "256.5" "109.3" "" "" "" "" "" "" "" "" "" "" "62.4" "59.4" "59.7" "67.2" "50.5" "57.6" "51.9" "41.3" "139.2" "109.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-475093268658479309" "False" "High" "IsMasterProtein" "P61599" "N-alpha-acetyltransferase 20 OS=Homo sapiens OX=9606 GN=NAA20 PE=1 SV=1" "0.000" "False" "7.594" "13" "2" "2" "2" "178" "20.4" "5.03" "5.69" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "51126" "ENSG00000173418" "NAA20" "A6NHA3; B2R4G4; hsa:51126; P61599; Q5TFT7; Q9D7H8; Q9H0Y4; Q9NQH6; Q9Y6D2" "Metapathway biotransformation Phase I and II" "" "1" "0" "1.192" "0.979" "1.093" "1.387" "1.097" "1.180" "1.093" "1.089" "1.542" "157.5" "187.8" "154.3" "172.1" "218.5" "172.8" "185.9" "172.2" "171.5" "242.9" "" "" "" "" "" "" "" "" "" "" "94.3" "97.6" "85.4" "80.8" "101.3" "88.5" "86.4" "77.3" "93.1" "242.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6836769617334137947" "False" "High" "IsMasterProtein" "Q96LA8" "Protein arginine N-methyltransferase 6 OS=Homo sapiens OX=9606 GN=PRMT6 PE=1 SV=1" "0.000" "False" "7.561" "6" "1" "1" "1" "375" "41.9" "5.44" "4.20" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf13649" "55170" "ENSG00000198890" "PRMT6" "A3KME1; B4DID8; hsa:55170; Q5T5Y5; Q6DKI4; Q96LA8; Q9NVR8" "Male infertility; Nitric oxide metabolism in cystic fibrosis" "RMTs methylate histone arginines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "784332711560809760" "False" "High" "IsMasterProtein" "P62072" "Mitochondrial import inner membrane translocase subunit Tim10 OS=Homo sapiens OX=9606 GN=TIMM10 PE=1 SV=1" "0.000" "False" "7.551" "26" "3" "4" "3" "90" "10.3" "6.29" "10.97" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "26519" "ENSG00000134809" "TIMM10" "A8K136; hsa:26519; P62072; Q9WV99; Q9WVA0; Q9Y5J8" "" "Mitochondrial protein degradation; Mitochondrial protein import" "2" "0" "0.990" "0.929" "0.966" "0.954" "0.933" "0.983" "1.139" "0.821" "0.272" "190.7" "188.8" "177.1" "184.1" "181.9" "177.9" "187.5" "217.2" "156.6" "51.8" "" "" "" "" "" "" "" "" "" "" "114.1" "98.1" "98.1" "86.4" "84.3" "91.1" "87.2" "97.5" "85.0" "51.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-997186877852076993" "False" "High" "IsMasterProtein" "Q9NYL9" "Tropomodulin-3 OS=Homo sapiens OX=9606 GN=TMOD3 PE=1 SV=1" "0.000" "False" "7.546" "8" "3" "3" "3" "352" "39.6" "5.19" "6.31" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton" "cytoskeletal activity" "Pf03250" "29766" "ENSG00000138594" "TMOD3" "B2R6G7; hsa:29766; Q9NT43; Q9NYL9; Q9NZR0" "VEGFA-VEGFR2 signaling" "RND3 GTPase cycle; Striated Muscle Contraction; RHOBTB2 GTPase cycle" "4" "0" "0.874" "1.157" "1.539" "0.682" "1.187" "0.890" "0.681" "1.500" "3.490" "21.5" "18.8" "24.9" "33.1" "14.6" "25.5" "19.1" "14.6" "32.2" "75.0" "" "" "" "" "" "" "" "" "" "" "12.9" "9.8" "13.8" "15.5" "6.8" "13.1" "8.9" "6.6" "17.5" "75.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1738440604026587204" "False" "High" "IsMasterProtein" "P60510" "Serine/threonine-protein phosphatase 4 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP4C PE=1 SV=1" "0.000" "False" "7.542" "4" "1" "2" "1" "307" "35.1" "5.06" "7.00" "1" "DNA metabolism;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00149" "5531" "ENSG00000149923" "PPP4C" "hsa:5531; P33172; P60510" "16p11.2 proximal deletion syndrome" "Processing of DNA double-strand break ends" "2" "0" "1.001" "0.860" "0.968" "0.906" "0.769" "0.873" "0.913" "1.028" "0.632" "117.1" "117.2" "100.7" "113.4" "106.1" "90.1" "102.2" "106.9" "120.4" "74.0" "" "" "" "" "" "" "" "" "" "" "70.1" "60.9" "55.8" "53.2" "49.2" "46.1" "47.5" "48.0" "65.3" "74.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7103280702382610433" "False" "High" "IsMasterProtein" "Q8IX90" "Spindle and kinetochore-associated protein 3 OS=Homo sapiens OX=9606 GN=SKA3 PE=1 SV=2" "0.000" "False" "7.538" "8" "3" "3" "3" "412" "46.3" "5.11" "5.03" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "" "221150" "ENSG00000165480" "SKA3" "A2A330; A2A331; B2RBY2; hsa:221150; Q5VZV5; Q86WR2; Q8IX90; Q8NBG1; Q96D22" "" "" "0" "0" "0.892" "1.034" "1.079" "1.247" "0.918" "1.370" "0.797" "0.867" "3.283" "37.3" "33.3" "38.6" "40.3" "46.6" "34.3" "51.2" "29.8" "32.4" "122.6" "" "" "" "" "" "" "" "" "" "" "22.3" "17.3" "21.4" "18.9" "21.6" "17.5" "23.8" "13.4" "17.6" "122.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7649239600803351534" "False" "High" "IsMasterProtein" "Q96JY6" "PDZ and LIM domain protein 2 OS=Homo sapiens OX=9606 GN=PDLIM2 PE=1 SV=1" "0.000" "False" "7.538" "6" "2" "2" "2" "352" "37.4" "8.72" "4.16" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595, Pf15936" "64236" "ENSG00000120913" "PDLIM2" "D3DSR5; hsa:64236; J3KNH4; Q7Z584; Q86WM8; Q8WZ29; Q96JY6; Q9H4L9; Q9H7I2" "" "" "0" "0" "1.023" "1.164" "0.853" "0.904" "1.149" "1.071" "1.017" "1.073" "1.154" "86.3" "88.3" "100.4" "73.6" "78.0" "99.1" "92.4" "87.8" "92.6" "99.6" "" "" "" "" "" "" "" "" "" "" "51.6" "45.9" "55.6" "34.5" "36.1" "50.7" "43.0" "39.4" "50.2" "99.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4718319405373936898" "False" "High" "IsMasterProtein" "Q5TA45" "Integrator complex subunit 11 OS=Homo sapiens OX=9606 GN=INTS11 PE=1 SV=2" "0.000" "False" "7.532" "7" "4" "4" "4" "600" "67.6" "8.06" "6.40" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07521, Pf10996, Pf16661, Pf21386" "54973" "ENSG00000127054" "INTS11" "A8K5S2; B3KPR3; B4DM87; G3V1S5; hsa:54973; Q5TA45; Q5TA46; Q5TA48; Q5TA52; Q5TA53; Q5TA54; Q7L3D7; Q96HY1; Q9BW36; Q9H0F9; Q9H8R5; Q9HAA6; Q9NWX9" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.263" "0.745" "1.217" "1.353" "1.153" "1.071" "1.231" "1.201" "1.001" "20.5" "25.9" "15.3" "25.0" "27.8" "23.6" "22.0" "25.3" "24.6" "20.5" "" "" "" "" "" "" "" "" "" "" "12.3" "13.5" "8.5" "11.7" "12.9" "12.1" "10.2" "11.3" "13.4" "20.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6449496976955696731" "False" "High" "IsMasterProtein" "Q9UHR5" "SAP30-binding protein OS=Homo sapiens OX=9606 GN=SAP30BP PE=1 SV=1" "0.000" "False" "7.504" "10" "3" "6" "3" "308" "33.9" "4.84" "14.54" "3" "other biological processes" "cytoskeleton;nucleus" "" "Pf07818" "29115" "ENSG00000161526" "SAP30BP" "B3KML7; hsa:29115; Q8N1R5; Q8TDR8; Q96D27; Q9UHR5" "" "NoRC negatively regulates rRNA expression" "1" "0" "1.057" "0.982" "1.019" "1.168" "1.065" "1.035" "1.148" "1.027" "0.581" "282.8" "298.9" "277.7" "288.3" "330.4" "301.1" "292.7" "324.8" "290.4" "164.4" "" "" "" "" "" "" "" "" "" "" "169.3" "155.3" "153.8" "135.4" "153.1" "154.1" "136.1" "145.8" "157.6" "164.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3575198767162097907" "False" "High" "IsMasterProtein" "Q9BXV9" "EKC/KEOPS complex subunit GON7 OS=Homo sapiens OX=9606 GN=GON7 PE=1 SV=2" "0.000" "False" "7.499" "26" "1" "1" "1" "100" "10.9" "4.27" "6.11" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf15387" "84520" "ENSG00000170270; ENSG00000275619" "GON7" "Q0D2N1; Q0P6C4; Q3B7W5; Q9BXV9" "" "" "0" "0" "1.422" "1.048" "1.339" "1.574" "1.096" "1.183" "1.392" "0.958" "0.797" "28.7" "40.9" "30.1" "38.5" "45.3" "31.5" "34.0" "40.0" "27.5" "22.9" "" "" "" "" "" "" "" "" "" "" "17.2" "21.2" "16.7" "18.1" "21.0" "16.1" "15.8" "18.0" "14.9" "22.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-145222249138625553" "False" "High" "IsMasterProtein" "Q9BYG3" "MKI67 FHA domain-interacting nucleolar phosphoprotein OS=Homo sapiens OX=9606 GN=NIFK PE=1 SV=1" "0.000" "False" "7.498" "11" "2" "2" "2" "293" "34.2" "9.88" "6.51" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf12196" "84365" "ENSG00000155438" "NIFK" "A8K788; hsa:84365; Q8TB66; Q96ED4; Q9BYG3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8173179408617438185" "False" "High" "IsMasterProtein" "P32929" "Cystathionine gamma-lyase OS=Homo sapiens OX=9606 GN=CTH PE=1 SV=3" "0.000" "False" "7.488" "11" "3" "3" "3" "405" "44.5" "6.70" "5.16" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01053" "1491" "ENSG00000116761" "CTH" "B4E1R2; E9PDV0; hsa:1491; P32929; Q53FB3; Q53Y79; Q9H4W7; Q9H4W8" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways; Methionine metabolism leading to sulfur amino acids and related disorders; Ferroptosis" "Degradation of cysteine and homocysteine; Metabolism of ingested SeMet, Sec, MeSec into H2Se; Cysteine formation from homocysteine" "12" "0" "1.119" "0.826" "1.139" "0.962" "0.964" "0.750" "0.777" "0.995" "0.703" "36.4" "40.7" "30.1" "41.5" "35.0" "35.1" "27.3" "28.3" "36.2" "25.6" "" "" "" "" "" "" "" "" "" "" "21.8" "21.2" "16.7" "19.5" "16.2" "18.0" "12.7" "12.7" "19.7" "25.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4005780129157962021" "False" "High" "IsMasterProtein" "Q9BUR4" "Telomerase Cajal body protein 1 OS=Homo sapiens OX=9606 GN=WRAP53 PE=1 SV=1" "0.000" "False" "7.487" "5" "2" "2" "2" "548" "59.3" "4.58" "3.71" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "55135" "ENSG00000141499" "WRAP53" "B3KPR9; D3DTQ4; hsa:55135; Q08ET9; Q9BUR4; Q9NW09" "" "Association of TriC/CCT with target proteins during biosynthesis; Telomere Extension By Telomerase" "2" "0" "0.825" "0.687" "0.824" "0.914" "0.863" "0.936" "0.926" "0.787" "0.746" "58.8" "48.5" "40.4" "48.5" "53.8" "50.8" "55.0" "54.4" "46.3" "43.9" "" "" "" "" "" "" "" "" "" "" "35.2" "25.2" "22.4" "22.8" "24.9" "26.0" "25.6" "24.4" "25.1" "43.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6090154179084716209" "False" "High" "IsMasterProtein" "P36551" "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial OS=Homo sapiens OX=9606 GN=CPOX PE=1 SV=3" "0.000" "False" "7.486" "8" "3" "5" "3" "454" "50.1" "8.25" "9.68" "3" "other metabolic processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf01218" "1371" "ENSG00000080819" "CPOX" "A8K275; B4DSD5; hsa:1371; P36551; Q14060; Q53F08; Q8IZ45; Q96AF3" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6265096555801149049" "False" "High" "IsMasterProtein" "P06132" "Uroporphyrinogen decarboxylase OS=Homo sapiens OX=9606 GN=UROD PE=1 SV=2" "0.000" "False" "7.482" "7" "2" "6" "2" "367" "40.8" "6.14" "18.53" "2" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01208" "7389" "ENSG00000126088" "UROD" "A8K762; hsa:7389; P06132; Q16863; Q16883; Q53YB8; Q53ZP6; Q6IB28; Q9BUZ0" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "3" "0" "1.180" "1.126" "1.079" "1.236" "1.089" "1.125" "1.173" "1.059" "0.874" "281.8" "332.5" "317.4" "304.0" "348.3" "306.9" "316.9" "330.4" "298.4" "246.2" "" "" "" "" "" "" "" "" "" "" "168.6" "172.8" "175.8" "142.7" "161.4" "157.1" "147.3" "148.3" "161.9" "246.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2492705213444431370" "False" "High" "IsMasterProtein" "Q8TE04" "Pantothenate kinase 1 OS=Homo sapiens OX=9606 GN=PANK1 PE=1 SV=2" "0.000" "False" "7.473" "5" "3" "4" "1" "598" "64.3" "7.56" "7.55" "3" "other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf03630" "53354" "ENSG00000152782" "PANK1" "A6NIP0; hsa:53354; Q7RTX6; Q7Z495; Q8TBQ8; Q8TE04" "" "Coenzyme A biosynthesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7892576250417935997" "False" "High" "IsMasterProtein" "A6NKD9" "Coiled-coil domain-containing protein 85C OS=Homo sapiens OX=9606 GN=CCDC85C PE=1 SV=1" "0.000" "False" "7.473" "6" "2" "2" "2" "419" "45.2" "6.96" "5.95" "2" "developmental processes" "other cell component" "" "Pf10226" "317762" "ENSG00000205476" "CCDC85C" "A6NKD9; hsa:317762" "" "" "0" "0" "1.071" "0.989" "1.000" "1.173" "1.105" "0.955" "1.146" "0.956" "0.666" "87.5" "93.7" "86.5" "87.5" "102.6" "96.7" "83.6" "100.2" "83.7" "58.3" "" "" "" "" "" "" "" "" "" "" "52.4" "48.7" "47.9" "41.1" "47.6" "49.5" "38.9" "45.0" "45.4" "58.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3133917976218081073" "False" "High" "IsMasterProtein" "Q9Y3D8" "Adenylate kinase isoenzyme 6 OS=Homo sapiens OX=9606 GN=AK6 PE=1 SV=1" "0.000" "False" "7.470" "16" "3" "3" "3" "172" "20.0" "4.58" "6.29" "3" "other metabolic processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf13238" "102157402" "ENSG00000085231; ENSG00000279247" "AK6" "A8MSZ6; hsa:102157402; Q5F2S9; Q9Y3D8" "" "Interconversion of nucleotide di- and triphosphates" "1" "0" "1.075" "1.099" "1.153" "1.137" "1.227" "1.295" "0.696" "1.041" "5.203" "63.8" "68.5" "70.1" "73.5" "72.5" "78.3" "82.6" "44.4" "66.4" "331.8" "" "" "" "" "" "" "" "" "" "" "38.2" "35.6" "38.8" "34.5" "33.6" "40.1" "38.4" "19.9" "36.0" "331.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5611096213630678464" "False" "High" "IsMasterProtein" "P11279" "Lysosome-associated membrane glycoprotein 1 OS=Homo sapiens OX=9606 GN=LAMP1 PE=1 SV=3" "0.000" "False" "7.469" "7" "3" "4" "3" "417" "44.9" "8.75" "8.41" "3" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01299, Pf21222" "3916" "ENSG00000185896" "LAMP1" "B4DWL3; hsa:3916; P11279; Q8WU33; Q96I40; Q9BRD2; Q9NP13" "" "Neutrophil degranulation" "1" "0" "1.371" "1.158" "1.323" "0.983" "1.156" "1.159" "1.248" "1.032" "0.567" "46.0" "63.0" "53.2" "60.9" "45.2" "53.2" "53.3" "57.4" "47.4" "26.1" "" "" "" "" "" "" "" "" "" "" "27.5" "32.8" "29.5" "28.6" "21.0" "27.2" "24.8" "25.8" "25.7" "26.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5464068146291938331" "False" "High" "IsMasterProtein" "P49840" "Glycogen synthase kinase-3 alpha OS=Homo sapiens OX=9606 GN=GSK3A PE=1 SV=2" "0.000" "False" "7.459" "5" "2" "3" "1" "483" "50.9" "8.75" "7.74" "2" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "2931" "ENSG00000105723" "GSK3A" "hsa:2931; O14959; P49840" "IL-5 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Wnt signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Nonalcoholic fatty liver disease; Insulin signaling; Glycogen synthesis and degradation; HDAC6 interactions in the central nervous system" "Constitutive Signaling by AKT1 E17K in Cancer; XBP1(S) activates chaperone genes; AKT phosphorylates targets in the cytosol; Suppression of apoptosis; Maturation of nucleoprotein; Maturation of nucleoprotein" "18" "0" "0.896" "1.118" "1.002" "0.927" "1.137" "1.038" "1.069" "0.978" "0.738" "42.8" "38.3" "47.8" "42.8" "39.7" "48.6" "44.4" "45.7" "41.8" "31.6" "" "" "" "" "" "" "" "" "" "" "25.6" "19.9" "26.5" "20.1" "18.4" "24.9" "20.6" "20.5" "22.7" "31.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3114131480513419355" "False" "High" "IsMasterProtein" "P62701" "Small ribosomal subunit protein eS4, X isoform OS=Homo sapiens OX=9606 GN=RPS4X PE=1 SV=2" "0.000" "False" "7.442" "10" "3" "6" "3" "263" "29.6" "10.15" "15.32" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00467, Pf00900, Pf08071, Pf16121" "6191" "ENSG00000198034" "RPS4X" "hsa:6191; P12631; P12750; P27576; P55831; P62701; Q14727; Q6IPY4" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "0.864" "0.973" "1.047" "1.110" "1.139" "0.943" "0.913" "1.052" "1.681" "310.7" "268.4" "302.4" "325.3" "345.1" "353.8" "293.0" "283.9" "326.8" "522.3" "" "" "" "" "" "" "" "" "" "" "186.0" "139.5" "167.5" "152.7" "159.9" "181.1" "136.2" "127.4" "177.3" "522.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3901447341290801043" "False" "High" "IsMasterProtein" "Q66PJ3" "ADP-ribosylation factor-like protein 6-interacting protein 4 OS=Homo sapiens OX=9606 GN=ARL6IP4 PE=1 SV=3" "0.000" "False" "7.440" "10" "2" "3" "2" "237" "26.4" "10.86" "8.58" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf10500" "51329" "ENSG00000182196" "ARL6IP4" "A4UCR8; B3V0L0; B3V0L1; hsa:51329; Q4F966; Q504R8; Q66PJ3; Q96BI2; Q9NR05; Q9P2R9" "" "" "0" "0" "1.055" "1.169" "1.070" "1.116" "1.160" "1.114" "1.184" "1.046" "0.656" "149.7" "157.9" "175.0" "160.1" "167.1" "173.6" "166.7" "177.2" "156.5" "98.3" "" "" "" "" "" "" "" "" "" "" "89.6" "82.1" "96.9" "75.2" "77.4" "88.9" "77.5" "79.6" "84.9" "98.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-658594625945977388" "False" "High" "IsMasterProtein" "O00139" "Kinesin-like protein KIF2A OS=Homo sapiens OX=9606 GN=KIF2A PE=1 SV=3" "0.000" "False" "7.437" "5" "4" "4" "3" "706" "79.9" "6.68" "8.92" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3796" "ENSG00000068796" "KIF2A" "A5YM42; A5YM54; B4DY54; D3DW97; E9PB70; hsa:3796; O00139; Q7Z5I3; Q8N5Q7" "" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "9" "0" "1.026" "0.945" "1.183" "1.277" "0.995" "0.873" "0.775" "1.015" "4.058" "122.9" "126.1" "116.1" "145.3" "156.9" "122.2" "107.3" "95.3" "124.7" "498.5" "" "" "" "" "" "" "" "" "" "" "73.5" "65.5" "64.3" "68.2" "72.7" "62.6" "49.9" "42.8" "67.7" "498.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4340156669496060526" "False" "High" "IsMasterProtein" "Q9Y3C6" "Peptidyl-prolyl cis-trans isomerase-like 1 OS=Homo sapiens OX=9606 GN=PPIL1 PE=1 SV=1" "0.000" "False" "7.435" "16" "3" "6" "3" "166" "18.2" "7.99" "14.73" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "other molecular function" "Pf00160" "51645" "ENSG00000137168" "PPIL1" "hsa:51645; O15001; Q5TDC9; Q9Y3C6" "" "mRNA Splicing - Major Pathway" "1" "0" "1.089" "1.041" "0.892" "1.209" "1.128" "1.320" "1.184" "1.108" "1.359" "112.9" "123.0" "117.5" "100.7" "136.6" "127.4" "149.0" "133.7" "125.1" "153.4" "" "" "" "" "" "" "" "" "" "" "67.6" "63.9" "65.1" "47.3" "63.3" "65.2" "69.3" "60.0" "67.9" "153.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4022881073250375863" "False" "High" "IsMasterProtein" "P16455" "Methylated-DNA--protein-cysteine methyltransferase OS=Homo sapiens OX=9606 GN=MGMT PE=1 SV=1" "0.000" "False" "7.434" "15" "2" "4" "2" "207" "21.6" "8.10" "4.93" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01035, Pf02870" "4255" "ENSG00000170430" "MGMT" "P16455; Q5VY78" "Direct reversal repair; DNA repair pathways, full network; p53 transcriptional gene network" "MGMT-mediated DNA damage reversal" "4" "0" "1.072" "0.911" "1.216" "1.274" "1.215" "1.019" "0.674" "1.046" "1.235" "24.4" "26.2" "22.3" "29.7" "31.1" "29.7" "24.9" "16.5" "25.5" "30.2" "" "" "" "" "" "" "" "" "" "" "14.6" "13.6" "12.3" "13.9" "14.4" "15.2" "11.6" "7.4" "13.9" "30.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3347831162215749093" "False" "High" "IsMasterProtein" "Q9UEW8" "STE20/SPS1-related proline-alanine-rich protein kinase OS=Homo sapiens OX=9606 GN=STK39 PE=1 SV=3" "0.000" "False" "7.432" "4" "2" "2" "2" "545" "59.4" "6.29" "6.74" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12202" "27347" "ENSG00000198648" "STK39" "O14774; Q53S90; Q53SL7; Q53SS1; Q9UER4; Q9UEW8; X5D9C8" "" "" "0" "0" "1.062" "1.140" "1.489" "1.023" "0.954" "1.351" "0.853" "1.165" "5.745" "22.2" "23.6" "25.3" "33.0" "22.7" "21.2" "30.0" "18.9" "25.9" "127.5" "" "" "" "" "" "" "" "" "" "" "13.3" "12.2" "14.0" "15.5" "10.5" "10.8" "13.9" "8.5" "14.0" "127.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3632960594176974073" "False" "High" "IsMasterProtein" "Q9UPN9" "E3 ubiquitin-protein ligase TRIM33 OS=Homo sapiens OX=9606 GN=TRIM33 PE=1 SV=3" "0.000" "False" "7.428" "2" "2" "3" "2" "1127" "122.5" "6.67" "2.98" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf00643" "51592" "ENSG00000197323" "TRIM33" "hsa:51592; O95855; Q5TG72; Q5TG73; Q5TG74; Q9C017; Q9UJ79; Q9UPN9" "Ectoderm differentiation" "Downregulation of SMAD2/3:SMAD4 transcriptional activity; Germ layer formation at gastrulation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4396257609671438072" "False" "High" "IsMasterProtein" "Q8IZL8" "Proline-, glutamic acid- and leucine-rich protein 1 OS=Homo sapiens OX=9606 GN=PELP1 PE=1 SV=2" "0.000" "False" "7.424" "4" "2" "2" "2" "1130" "119.6" "4.34" "3.80" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08166, Pf08167" "27043" "ENSG00000141456" "PELP1" "hsa:27043; O15450; Q5EGN3; Q6NTE6; Q8IZL8; Q96FT1; Q9BU60" "" "Major pathway of rRNA processing in the nucleolus and cytosol; PTK6 Expression" "2" "0" "1.051" "0.878" "0.900" "1.141" "0.889" "1.365" "0.781" "0.768" "0.597" "23.0" "24.1" "20.1" "20.7" "26.2" "20.4" "31.3" "17.9" "17.6" "13.7" "" "" "" "" "" "" "" "" "" "" "13.7" "12.5" "11.2" "9.7" "12.1" "10.5" "14.6" "8.0" "9.6" "13.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4849374493010714997" "False" "High" "IsMasterProtein" "Q92673" "Sortilin-related receptor OS=Homo sapiens OX=9606 GN=SORL1 PE=1 SV=2" "0.000" "False" "7.414" "1" "3" "3" "3" "2214" "248.3" "5.55" "6.35" "3" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00041, Pf00057, Pf00058, Pf15901, Pf15902" "6653" "ENSG00000137642" "SORL1" "B2RNX7; hsa:6653; Q92673; Q92856" "" "Amyloid fiber formation" "1" "0" "1.322" "1.084" "1.340" "1.043" "1.427" "1.489" "1.374" "0.996" "1.217" "51.6" "68.2" "56.0" "69.1" "53.8" "73.7" "76.8" "70.9" "51.4" "62.8" "" "" "" "" "" "" "" "" "" "" "30.9" "35.4" "31.0" "32.5" "24.9" "37.7" "35.7" "31.8" "27.9" "62.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4941414792679987409" "False" "High" "IsMasterProtein" "Q00403" "Transcription initiation factor IIB OS=Homo sapiens OX=9606 GN=GTF2B PE=1 SV=1" "0.000" "False" "7.407" "11" "3" "3" "3" "316" "34.8" "8.35" "7.44" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00382, Pf08271" "2959" "ENSG00000137947" "GTF2B" "A8K1A7; hsa:2959; Q00403; Q5JS30" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "10" "0" "1.039" "0.798" "1.095" "1.134" "1.105" "1.139" "0.531" "0.980" "3.892" "65.8" "68.4" "52.5" "72.1" "74.7" "72.8" "75.0" "34.9" "64.6" "256.3" "" "" "" "" "" "" "" "" "" "" "39.4" "35.6" "29.1" "33.9" "34.6" "37.3" "34.9" "15.7" "35.0" "256.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "76993751311903605" "False" "High" "IsMasterProtein" "Q9GZZ9" "Ubiquitin-like modifier-activating enzyme 5 OS=Homo sapiens OX=9606 GN=UBA5 PE=1 SV=1" "0.000" "False" "7.403" "5" "2" "4" "2" "404" "44.8" "4.84" "10.82" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00899" "79876" "ENSG00000081307" "UBA5" "A6NJL3; D3DNC8; hsa:79876; Q96ST1; Q9GZZ9" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.120" "1.007" "0.940" "1.086" "1.165" "0.987" "0.939" "0.910" "0.924" "152.0" "170.3" "153.1" "142.9" "165.2" "177.1" "150.1" "142.8" "138.3" "140.5" "" "" "" "" "" "" "" "" "" "" "91.0" "88.5" "84.8" "67.1" "76.6" "90.6" "69.8" "64.1" "75.0" "140.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602671086497481481" "False" "High" "IsMasterProtein" "O43709" "18S rRNA (guanine-N(7))-methyltransferase OS=Homo sapiens OX=9606 GN=BUD23 PE=1 SV=2" "0.000" "False" "7.403" "9" "2" "2" "2" "281" "31.9" "8.73" "6.93" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08241, Pf12589" "114049" "ENSG00000071462" "BUD23" "A8K501; C9K060; hsa:114049; O43709; Q96P12; Q9BQ58; Q9HBP9" "7q11.23 copy number variation syndrome" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "3" "0" "0.860" "0.806" "0.905" "0.976" "0.943" "0.901" "0.887" "0.856" "0.797" "225.2" "193.6" "181.6" "203.9" "219.8" "212.5" "203.0" "199.8" "192.8" "179.6" "" "" "" "" "" "" "" "" "" "" "134.8" "100.6" "100.5" "95.7" "101.9" "108.8" "94.4" "89.7" "104.6" "179.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2304396321486536577" "False" "High" "IsMasterProtein" "Q8IXQ4" "GPALPP motifs-containing protein 1 OS=Homo sapiens OX=9606 GN=GPALPP1 PE=1 SV=1" "0.000" "False" "7.393" "6" "2" "3" "2" "340" "38.1" "5.41" "9.65" "2" "" "" "" "Pf12572" "55425" "ENSG00000133114" "GPALPP1" "A8K8X8; hsa:55425; Q05BX8; Q05D87; Q5T3Z3; Q5T3Z5; Q8IXQ4; Q9C0F9; Q9H2R0; Q9P0W6" "" "" "0" "0" "0.841" "0.849" "0.809" "0.825" "0.812" "0.852" "1.015" "0.893" "0.343" "293.3" "246.8" "249.1" "237.3" "242.0" "238.1" "249.9" "297.6" "261.8" "100.5" "" "" "" "" "" "" "" "" "" "" "175.5" "128.2" "137.9" "111.4" "112.2" "121.9" "116.2" "133.6" "142.0" "100.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1890779364620067180" "False" "High" "IsMasterProtein" "Q96CD2" "Phosphopantothenoylcysteine decarboxylase OS=Homo sapiens OX=9606 GN=PPCDC PE=1 SV=2" "0.000" "False" "7.389" "17" "3" "3" "3" "204" "22.4" "6.10" "6.77" "3" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02441" "60490" "ENSG00000138621" "PPCDC" "hsa:60490; Q96CD2; Q96SX0; Q9HC17" "" "Coenzyme A biosynthesis" "1" "0" "0.976" "0.939" "0.901" "1.053" "0.902" "1.349" "1.042" "1.165" "0.747" "89.5" "87.4" "84.0" "80.7" "94.3" "80.7" "120.7" "93.2" "104.3" "66.9" "" "" "" "" "" "" "" "" "" "" "53.5" "45.4" "46.5" "37.9" "43.7" "41.3" "56.1" "41.8" "56.6" "66.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3524460011519656721" "False" "High" "IsMasterProtein" "P50749" "Ras association domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RASSF2 PE=1 SV=1" "0.000" "False" "7.376" "10" "2" "4" "2" "326" "37.8" "8.84" "9.23" "2" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity" "Pf00788, Pf16517" "9770" "ENSG00000101265" "RASSF2" "A6NIX9; A8K5Z3; hsa:9770; P50749; Q17S06; Q53HD0; Q6AHZ2; Q8IZA5" "Pleural mesothelioma" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5720484629679422275" "False" "High" "IsMasterProtein" "Q8WUA2" "Peptidyl-prolyl cis-trans isomerase-like 4 OS=Homo sapiens OX=9606 GN=PPIL4 PE=1 SV=1" "0.000" "False" "7.348" "5" "3" "3" "3" "492" "57.2" "5.92" "7.01" "3" "" "cytosol;nucleus" "other molecular function" "Pf00076, Pf00160" "85313" "ENSG00000131013" "PPIL4" "B2RD34; hsa:85313; Q7Z3Q5; Q8WUA2" "" "mRNA Splicing - Major Pathway" "1" "0" "1.400" "1.514" "1.239" "1.331" "1.206" "0.933" "0.810" "1.330" "3.805" "98.5" "137.9" "149.1" "122.0" "131.0" "118.7" "91.9" "79.7" "131.0" "374.7" "" "" "" "" "" "" "" "" "" "" "58.9" "71.7" "82.6" "57.3" "60.7" "60.8" "42.7" "35.8" "71.1" "374.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7200056701513102621" "False" "High" "IsMasterProtein" "P12236" "ADP/ATP translocase 3 OS=Homo sapiens OX=9606 GN=SLC25A6 PE=1 SV=4" "0.000" "False" "7.346" "9" "3" "4" "3" "298" "32.8" "9.74" "7.47" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf00153" "293" "ENSG00000169100; ENSG00000292334" "SLC25A6" "hsa:293; P12236; Q96C49" "Electron transport chain: OXPHOS system in mitochondria; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Mitochondrial protein import; Mitochondrial protein degradation; Influenza Virus Induced Apoptosis; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4939449039103849626" "False" "High" "IsMasterProtein" "Q96G74" "OTU domain-containing protein 5 OS=Homo sapiens OX=9606 GN=OTUD5 PE=1 SV=1" "0.000" "False" "7.340" "8" "3" "3" "3" "571" "60.6" "6.54" "4.68" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf02338" "55593" "ENSG00000068308; ENSG00000292211" "OTUD5" "B4DGG7; G5E9D7; hsa:55593; Q4KMN9; Q8N6T5; Q96G74; Q9H650; Q9H9U0; Q9NT65" "Gastric cancer network 2; Novel intracellular components of RIG-I-like receptor pathway" "Ovarian tumor domain proteases; Negative regulators of DDX58/IFIH1 signaling" "4" "0" "1.147" "1.228" "1.099" "1.500" "1.212" "1.255" "1.519" "1.118" "1.201" "19.9" "22.8" "24.4" "21.8" "29.8" "24.1" "25.0" "30.2" "22.2" "23.9" "" "" "" "" "" "" "" "" "" "" "11.9" "11.9" "13.5" "10.3" "13.8" "12.3" "11.6" "13.6" "12.1" "23.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5869827592286108947" "False" "High" "IsMasterProtein" "Q9UPQ9" "Trinucleotide repeat-containing gene 6B protein OS=Homo sapiens OX=9606 GN=TNRC6B PE=1 SV=4" "0.000" "False" "7.332" "2" "2" "2" "2" "1833" "193.9" "6.76" "4.89" "2" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf10427, Pf16608" "23112" "ENSG00000100354" "TNRC6B" "B0QY73; B0QY78; B4DGC0; hsa:23112; Q5TH52; Q8TBX2; Q9UPQ9" "" "Oxidative Stress Induced Senescence; MAPK6/MAPK4 signaling; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Ca2+ pathway; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-309007205683403427" "False" "High" "IsMasterProtein" "Q8IWS0" "PHD finger protein 6 OS=Homo sapiens OX=9606 GN=PHF6 PE=1 SV=1" "0.000" "False" "7.315" "11" "4" "5" "4" "365" "41.3" "8.68" "5.40" "4" "developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf13771" "84295" "ENSG00000156531" "PHF6" "A8K230; B4E0G4; D3DTG3; E9PC97; hsa:84295; Q5JRC7; Q5JRC8; Q8IWS0; Q96JK3; Q9BRU0" "Mesodermal commitment pathway" "" "1" "0" "1.334" "1.099" "1.098" "1.208" "0.993" "1.124" "0.765" "1.165" "4.361" "142.0" "189.4" "156.1" "156.0" "171.5" "141.0" "159.6" "108.7" "165.5" "619.5" "" "" "" "" "" "" "" "" "" "" "85.0" "98.4" "86.5" "73.2" "79.5" "72.2" "74.2" "48.8" "89.8" "619.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3575991461264525713" "False" "High" "IsMasterProtein" "Q99933" "BAG family molecular chaperone regulator 1 OS=Homo sapiens OX=9606 GN=BAG1 PE=1 SV=4" "0.000" "False" "7.315" "10" "3" "4" "3" "345" "38.8" "7.81" "6.08" "3" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf02179" "573" "ENSG00000107262" "BAG1" "hsa:573; O75315; Q14414; Q53H32; Q5VZE8; Q5VZE9; Q5VZF0; Q96TG2; Q99933; Q9Y2V4" "Androgen receptor signaling pathway" "Regulation of HSF1-mediated heat shock response" "2" "0" "1.941" "1.884" "1.387" "1.984" "1.484" "2.274" "1.779" "1.901" "2.108" "19.4" "37.7" "36.6" "26.9" "38.5" "28.8" "44.1" "34.5" "36.9" "40.9" "" "" "" "" "" "" "" "" "" "" "11.6" "19.6" "20.3" "12.6" "17.9" "14.7" "20.5" "15.5" "20.0" "40.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6107269265140402008" "False" "High" "IsMasterProtein" "P10109" "Adrenodoxin, mitochondrial OS=Homo sapiens OX=9606 GN=FDX1 PE=1 SV=1" "0.000" "False" "7.291" "14" "3" "5" "3" "184" "19.4" "5.83" "13.81" "3" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00111" "2230" "ENSG00000137714" "FDX1" "B0YJ14; hsa:2230; P10109; Q53YD6" "Iron-sulfur cluster biogenesis" "Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin" "6" "0" "1.001" "1.024" "1.134" "1.035" "0.958" "1.072" "1.074" "1.028" "0.772" "204.2" "204.5" "209.1" "231.6" "211.5" "195.6" "218.9" "219.3" "210.0" "157.8" "" "" "" "" "" "" "" "" "" "" "122.2" "106.3" "115.8" "108.7" "98.0" "100.2" "101.8" "98.5" "113.9" "157.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8260610778738387308" "False" "High" "IsMasterProtein" "Q13907" "Isopentenyl-diphosphate Delta-isomerase 1 OS=Homo sapiens OX=9606 GN=IDI1 PE=1 SV=2" "0.000" "False" "7.283" "11" "3" "4" "3" "227" "26.3" "6.34" "10.58" "3" "other metabolic processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00293" "3422" "ENSG00000067064" "IDI1" "B4E155; hsa:3422; Q13907; Q32Q13; Q53GQ6; Q86U81; Q8WUX8; Q96IZ4; Q9BQ74" "Target of rapamycin signaling; Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Exercise-induced circadian regulation; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "11" "0" "1.005" "1.075" "0.803" "0.937" "1.066" "0.944" "1.126" "1.062" "0.690" "312.1" "313.7" "335.6" "250.4" "292.6" "332.8" "294.5" "351.4" "331.3" "215.5" "" "" "" "" "" "" "" "" "" "" "186.8" "163.0" "185.8" "117.6" "135.6" "170.4" "136.9" "157.8" "179.8" "215.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-437633753378296153" "False" "High" "IsMasterProtein" "Q9UKI8" "Serine/threonine-protein kinase tousled-like 1 OS=Homo sapiens OX=9606 GN=TLK1 PE=1 SV=2" "0.000" "False" "7.263" "4" "3" "4" "1" "766" "86.6" "8.72" "7.47" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "nucleus" "kinase activity;other molecular function" "Pf00069" "9874" "ENSG00000198586" "TLK1" "B3KR15; B4DX87; hsa:9874; Q14150; Q8N591; Q9NYH2; Q9UKI8; Q9Y4F6" "miRNA regulation of DNA damage response; Pathways affected in adenoid cystic carcinoma; DNA damage response" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5735228591980069382" "False" "High" "IsMasterProtein" "Q9HD42" "Charged multivesicular body protein 1a OS=Homo sapiens OX=9606 GN=CHMP1A PE=1 SV=1" "0.000" "False" "7.261" "12" "3" "7" "3" "196" "21.7" "8.06" "7.19" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "5119" "ENSG00000131165" "CHMP1A" "A2RU09; hsa:5119; Q14468; Q15779; Q96G31; Q9HD42" "" "HCMV Late Events" "1" "0" "0.935" "0.835" "1.055" "1.172" "0.968" "1.047" "0.877" "0.967" "0.702" "286.0" "267.3" "238.7" "301.8" "335.2" "276.8" "299.4" "250.8" "276.5" "200.8" "" "" "" "" "" "" "" "" "" "" "171.1" "138.9" "132.2" "141.7" "155.4" "141.7" "139.2" "112.6" "150.0" "200.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4633912985078584352" "False" "High" "IsMasterProtein" "P07948" "Tyrosine-protein kinase Lyn OS=Homo sapiens OX=9606 GN=LYN PE=1 SV=3" "0.000" "False" "7.239" "4" "2" "4" "1" "512" "58.5" "7.11" "12.23" "2" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "4067" "ENSG00000254087" "LYN" "A0AVQ5; hsa:4067; P07948" "IL-5 signaling pathway; RANKL/RANK signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; GDNF signaling" "FCERI mediated NF-kB activation; FCGR activation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of signaling by CBL; EPHB-mediated forward signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Regulation of KIT signaling; EPH-ephrin mediated repulsion of cells; EPHA-mediated growth cone collapse; Signaling by CSF1 (M-CSF) in myeloid cells; CD28 co-stimulation; PECAM1 interactions; CTLA4 inhibitory signaling; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; CD22 mediated BCR regulation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); GPVI-mediated activation cascade; Cyclin D associated events in G1; Growth hormone receptor signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; Platelet Adhesion to exposed collagen; CD209 (DC-SIGN) signaling; Dectin-2 family" "45" "0" "1.220" "1.033" "0.985" "0.964" "1.253" "1.099" "1.290" "1.494" "1.616" "60.2" "73.4" "62.2" "59.3" "58.0" "75.4" "66.1" "77.7" "90.0" "97.3" "" "" "" "" "" "" "" "" "" "" "36.0" "38.2" "34.4" "27.8" "26.9" "38.6" "30.8" "34.9" "48.8" "97.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7190222159830229495" "False" "High" "IsMasterProtein" "Q9H0A0" "RNA cytidine acetyltransferase OS=Homo sapiens OX=9606 GN=NAT10 PE=1 SV=2" "0.000" "False" "7.239" "2" "2" "2" "2" "1025" "115.7" "8.27" "4.65" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05127, Pf08351, Pf13718, Pf13725" "55226" "ENSG00000135372" "NAT10" "B4DFD5; E7ESU4; E9PMN9; hsa:55226; Q86WK5; Q9C0F4; Q9H0A0; Q9HA61; Q9NVF2" "Metapathway biotransformation Phase I and II" "rRNA modification in the nucleus and cytosol" "2" "0" "1.123" "0.994" "0.823" "1.026" "1.397" "1.342" "0.391" "0.725" "2.768" "16.6" "18.7" "16.5" "13.7" "17.0" "23.2" "22.3" "6.5" "12.0" "46.0" "" "" "" "" "" "" "" "" "" "" "9.9" "9.7" "9.1" "6.4" "7.9" "11.9" "10.4" "2.9" "6.5" "46.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8303897606251246511" "False" "High" "IsMasterProtein" "Q96HW7" "Integrator complex subunit 4 OS=Homo sapiens OX=9606 GN=INTS4 PE=1 SV=2" "0.000" "False" "7.227" "3" "3" "3" "3" "963" "108.1" "6.44" "4.77" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf13646, Pf20168" "92105" "ENSG00000149262" "INTS4" "hsa:92105; Q2YD62; Q6PJG4; Q7Z4E7; Q96G32; Q96GA1; Q96HW7; Q9BRC0" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "0.845" "1.021" "0.971" "1.129" "1.340" "0.763" "0.927" "0.771" "0.752" "39.7" "33.5" "40.5" "38.5" "44.8" "53.1" "30.3" "36.8" "30.6" "29.8" "" "" "" "" "" "" "" "" "" "" "23.7" "17.4" "22.4" "18.1" "20.8" "27.2" "14.1" "16.5" "16.6" "29.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6079513439335487390" "False" "High" "IsMasterProtein" "Q9UGV2" "Protein NDRG3 OS=Homo sapiens OX=9606 GN=NDRG3 PE=1 SV=2" "0.000" "False" "7.225" "6" "1" "1" "1" "375" "41.4" "5.31" "4.59" "1" "signal transduction;other biological processes" "other cell component" "" "Pf03096" "57446" "ENSG00000101079" "NDRG3" "A2A2S8; E1P5U7; E1P5U8; hsa:57446; Q5TH32; Q96PL8; Q96SM2; Q9BXY7; Q9H3N7; Q9H411; Q9H8J6; Q9UGV2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "High" "Not Found" "High" "Not Found" "Not Found" "Not Found" "Not Found" "High" "1" "" "5970441865792546005" "False" "High" "IsMasterProtein" "P04920" "Anion exchange protein 2 OS=Homo sapiens OX=9606 GN=SLC4A2 PE=1 SV=4" "0.000" "False" "7.224" "2" "2" "3" "2" "1241" "136.9" "6.29" "8.47" "2" "transport;developmental processes;other biological processes" "plasma membrane;other membranes" "transporter activity;other molecular function" "Pf00955, Pf07565" "6522" "ENSG00000164889" "SLC4A2" "B2R6T0; B4DIT0; D3DX05; F8W682; hsa:6522; P04920; Q45EY5; Q969L3" "Proximal tubule transport" "Bicarbonate transporters" "2" "0" "1.059" "0.980" "1.152" "1.139" "0.889" "1.149" "1.119" "1.091" "0.916" "80.7" "85.5" "79.1" "93.1" "91.9" "71.8" "92.8" "90.4" "88.1" "74.0" "" "" "" "" "" "" "" "" "" "" "48.3" "44.4" "43.8" "43.7" "42.6" "36.8" "43.1" "40.6" "47.8" "74.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4713550819086734085" "False" "High" "IsMasterProtein" "Q96AT9" "Ribulose-phosphate 3-epimerase OS=Homo sapiens OX=9606 GN=RPE PE=1 SV=1" "0.000" "False" "7.208" "7" "2" "12" "2" "228" "24.9" "5.58" "27.66" "2" "other metabolic processes" "cytosol" "other molecular function" "Pf00834" "6120" "ENSG00000197713" "RPE" "A8K4S0; B4E016; C9JPQ7; hsa:6120; O43767; Q53TV9; Q8N215; Q96AT9; Q96N34; Q9BSB5" "Pentose phosphate metabolism; Pentose phosphate pathway in senescent cells" "Pentose phosphate pathway" "3" "0" "1.035" "0.925" "1.118" "1.060" "0.997" "1.114" "1.175" "1.003" "0.584" "967.6" "1001.7" "894.9" "1082.2" "1025.2" "964.4" "1077.6" "1136.6" "970.1" "565.3" "" "" "" "" "" "" "" "" "" "" "579.0" "520.6" "495.6" "508.1" "475.2" "493.7" "501.0" "510.3" "526.3" "565.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4971008711368622204" "False" "High" "IsMasterProtein" "Q9BVW5" "TIMELESS-interacting protein OS=Homo sapiens OX=9606 GN=TIPIN PE=1 SV=2" "0.000" "False" "7.195" "7" "2" "2" "2" "301" "34.5" "4.82" "7.55" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07962" "54962" "ENSG00000075131" "TIPIN" "B2CW64; hsa:54962; Q9BVW5; Q9NWZ6" "" "Processing of DNA double-strand break ends" "1" "0" "1.244" "1.423" "1.189" "1.366" "1.029" "1.707" "0.932" "1.673" "1.547" "28.8" "35.8" "40.9" "34.2" "39.3" "29.6" "49.1" "26.8" "48.1" "44.5" "" "" "" "" "" "" "" "" "" "" "17.2" "18.6" "22.7" "16.1" "18.2" "15.1" "22.8" "12.0" "26.1" "44.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8217852517475646555" "False" "High" "IsMasterProtein" "Q9H3U1" "Protein unc-45 homolog A OS=Homo sapiens OX=9606 GN=UNC45A PE=1 SV=1" "0.000" "False" "7.194" "4" "3" "3" "3" "944" "103.0" "6.07" "5.00" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf11701, Pf13181" "55898" "ENSG00000140553" "UNC45A" "A8K6F7; hsa:55898; Q7L3Y6; Q9H3U1; Q9H3U8; Q9NSE8; Q9NSE9" "" "" "0" "0" "0.813" "0.864" "0.797" "0.992" "0.985" "1.023" "0.010" "1.178" "7.550" "45.7" "37.1" "39.4" "36.4" "45.3" "45.0" "46.7" "0.0" "53.8" "344.7" "" "" "" "" "" "" "" "" "" "" "27.3" "19.3" "21.8" "17.1" "21.0" "23.0" "21.7" "0.0" "29.2" "344.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3251544276452061183" "False" "High" "IsMasterProtein" "P26368" "Splicing factor U2AF 65 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF2 PE=1 SV=4" "0.000" "False" "7.187" "5" "3" "6" "3" "475" "53.5" "9.09" "9.61" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "11338" "ENSG00000063244" "U2AF2" "hsa:11338; P26368; Q96HC5" "mRNA processing; Warburg effect modulated by deubiquitinating enzymes and their substrates" "mRNA Splicing - Major Pathway; Protein hydroxylation; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "7" "0" "1.240" "1.371" "1.475" "1.276" "1.190" "1.403" "1.188" "1.161" "1.329" "244.8" "303.6" "335.7" "361.0" "312.4" "291.3" "343.5" "290.7" "284.3" "325.4" "" "" "" "" "" "" "" "" "" "" "146.5" "157.8" "185.9" "169.5" "144.8" "149.1" "159.7" "130.5" "154.2" "325.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1734934898581359440" "False" "High" "IsMasterProtein" "P61457" "Pterin-4-alpha-carbinolamine dehydratase OS=Homo sapiens OX=9606 GN=PCBD1 PE=1 SV=2" "0.000" "False" "7.185" "16" "2" "5" "1" "104" "12.0" "6.80" "15.73" "2" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf01329" "5092" "ENSG00000166228" "PCBD1" "hsa:5092; P61457; P70519; P80095; Q9D930" "" "Phenylalanine metabolism" "1" "0" "1.069" "1.285" "1.137" "1.311" "1.204" "1.187" "0.971" "1.146" "0.759" "151.5" "161.9" "194.7" "172.2" "198.5" "182.4" "179.8" "147.1" "173.6" "115.0" "" "" "" "" "" "" "" "" "" "" "90.6" "84.1" "107.8" "80.9" "92.0" "93.4" "83.6" "66.1" "94.2" "115.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-143757823348630571" "False" "High" "IsMasterProtein" "Q8IV08" "5'-3' exonuclease PLD3 OS=Homo sapiens OX=9606 GN=PLD3 PE=1 SV=1" "0.000" "False" "7.169" "4" "2" "3" "2" "490" "54.7" "6.47" "8.42" "2" "DNA metabolism;stress response;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf13918" "23646" "ENSG00000105223" "PLD3" "hsa:23646; Q8IV08; Q92853; Q9BW87" "" "Role of phospholipids in phagocytosis; Synthesis of PG" "2" "0" "1.020" "0.994" "1.008" "1.139" "1.146" "1.114" "1.167" "0.955" "0.869" "96.8" "98.8" "96.2" "97.6" "110.3" "111.0" "107.8" "112.9" "92.4" "84.1" "" "" "" "" "" "" "" "" "" "" "57.9" "51.3" "53.3" "45.8" "51.1" "56.8" "50.1" "50.7" "50.2" "84.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8642503759764886067" "False" "High" "IsMasterProtein" "P49454" "Centromere protein F OS=Homo sapiens OX=9606 GN=CENPF PE=1 SV=3" "0.000" "False" "7.152" "1" "3" "3" "3" "3114" "357.3" "5.10" "5.03" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10473, Pf10481, Pf10490" "1063" "ENSG00000117724" "CENPF" "hsa:1063; P49454; Q13171; Q13246; Q5VVM7" "Gastric cancer network 1; Ciliopathies" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Polo-like kinase mediated events" "9" "0" "1.239" "1.130" "1.021" "1.181" "1.200" "1.110" "0.970" "1.326" "1.364" "67.1" "83.1" "75.9" "68.6" "79.3" "80.5" "74.5" "65.1" "89.0" "91.6" "" "" "" "" "" "" "" "" "" "" "40.2" "43.2" "42.0" "32.2" "36.8" "41.2" "34.6" "29.2" "48.3" "91.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6662749909958562405" "False" "High" "IsMasterProtein" "Q99467" "CD180 antigen OS=Homo sapiens OX=9606 GN=CD180 PE=1 SV=2" "0.000" "False" "7.138" "5" "2" "2" "2" "661" "74.1" "6.43" "5.22" "2" "cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytoskeleton;nucleus" "" "Pf13855, Pf18831" "4064" "ENSG00000134061" "CD180" "B2R7Z7; hsa:4064; Q32MM5; Q99467" "" "Toll Like Receptor 4 (TLR4) Cascade" "1" "0" "1.182" "1.054" "1.343" "1.624" "1.105" "1.042" "1.590" "1.780" "0.856" "16.5" "19.5" "17.4" "22.2" "26.8" "18.2" "17.2" "26.3" "29.4" "14.1" "" "" "" "" "" "" "" "" "" "" "9.9" "10.1" "9.6" "10.4" "12.4" "9.3" "8.0" "11.8" "15.9" "14.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1014508030414011044" "False" "High" "IsMasterProtein" "P62899" "Large ribosomal subunit protein eL31 OS=Homo sapiens OX=9606 GN=RPL31 PE=1 SV=1" "0.000" "False" "7.132" "22" "3" "3" "3" "125" "14.5" "10.54" "7.80" "3" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01198" "6160" "ENSG00000071082" "RPL31" "B7Z4K2; D3DVJ4; hsa:6160; P12947; P62899; Q53SQ5; Q6IRZ0; Q6LBJ6" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis" "14" "0" "0.821" "0.889" "1.002" "0.899" "0.926" "0.966" "1.079" "1.013" "0.871" "107.0" "87.8" "95.1" "107.2" "96.2" "99.1" "103.4" "115.4" "108.4" "93.2" "" "" "" "" "" "" "" "" "" "" "64.0" "45.6" "52.6" "50.3" "44.6" "50.7" "48.1" "51.8" "58.8" "93.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5208220757799786637" "False" "High" "IsMasterProtein" "Q9BTC8" "Metastasis-associated protein MTA3 OS=Homo sapiens OX=9606 GN=MTA3 PE=1 SV=2" "0.000" "False" "7.129" "6" "3" "3" "1" "594" "67.5" "8.57" "2.57" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "57504" "ENSG00000057935" "MTA3" "hsa:57504; Q9BTC8; Q9NSP2; Q9ULF4" "Pre-implantation embryo; Effect of progerin on genes involved in progeria" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3981569091438122921" "False" "High" "IsMasterProtein" "Q8N4P3" "Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 OS=Homo sapiens OX=9606 GN=HDDC3 PE=1 SV=3" "0.000" "False" "7.125" "13" "2" "2" "2" "179" "20.3" "6.74" "6.70" "2" "" "" "other molecular function" "Pf13328" "374659" "ENSG00000184508" "HDDC3" "hsa:374659; Q8N4P3" "" "" "0" "0" "1.217" "1.003" "1.043" "1.159" "1.200" "1.249" "1.235" "1.184" "0.718" "188.7" "229.7" "189.3" "196.8" "218.7" "226.3" "235.6" "233.0" "223.4" "135.5" "" "" "" "" "" "" "" "" "" "" "112.9" "119.3" "104.8" "92.4" "101.4" "115.9" "109.6" "104.6" "121.2" "135.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "567113707807287491" "False" "High" "IsMasterProtein" "Q8NBT2" "Kinetochore protein Spc24 OS=Homo sapiens OX=9606 GN=SPC24 PE=1 SV=3" "0.000" "False" "7.114" "9" "2" "4" "2" "197" "22.4" "4.70" "7.42" "2" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf08286" "147841" "ENSG00000161888" "SPC24" "B4DZZ7; C9JGC4; hsa:147841; Q8NBT2" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.682" "0.941" "0.802" "1.211" "0.872" "1.067" "0.425" "0.908" "5.219" "51.6" "35.2" "48.5" "41.4" "62.4" "45.0" "55.0" "21.9" "46.8" "269.1" "" "" "" "" "" "" "" "" "" "" "30.9" "18.3" "26.9" "19.4" "28.9" "23.0" "25.6" "9.8" "25.4" "269.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3716051439609727834" "False" "High" "IsMasterProtein" "Q9NW82" "WD repeat-containing protein 70 OS=Homo sapiens OX=9606 GN=WDR70 PE=1 SV=1" "0.000" "False" "7.100" "4" "3" "4" "3" "654" "73.2" "6.33" "10.75" "3" "" "nucleus;other cell component" "other molecular function" "Pf00400" "55100" "ENSG00000082068" "WDR70" "hsa:55100; Q9H053; Q9NW82" "" "mRNA Splicing - Major Pathway" "1" "0" "1.040" "1.067" "1.068" "1.074" "1.097" "1.070" "1.090" "0.945" "0.859" "158.0" "164.4" "168.5" "168.7" "169.7" "173.4" "169.1" "172.2" "149.4" "135.7" "" "" "" "" "" "" "" "" "" "" "94.6" "85.4" "93.3" "79.2" "78.7" "88.8" "78.6" "77.3" "81.1" "135.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3101677286908017403" "False" "High" "IsMasterProtein" "Q9Y450" "HBS1-like protein OS=Homo sapiens OX=9606 GN=HBS1L PE=1 SV=1" "0.000" "False" "7.097" "7" "3" "4" "3" "684" "75.4" "6.61" "4.54" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144, Pf08938" "10767" "ENSG00000112339" "HBS1L" "B7Z365; hsa:10767; Q4VX89; Q4VX90; Q5T7G3; Q8NDW9; Q9UPW3; Q9Y450" "" "mRNA decay by 3' to 5' exoribonuclease" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6077742637667714135" "False" "High" "IsMasterProtein" "Q00535" "Cyclin-dependent kinase 5 OS=Homo sapiens OX=9606 GN=CDK5 PE=1 SV=3" "0.000" "False" "7.092" "10" "3" "5" "2" "292" "33.3" "7.66" "11.69" "3" "cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "1020" "ENSG00000164885" "CDK5" "A1XKG3; hsa:1020; Q00535" "miRNA regulation of DNA damage response; Nicotine effect on dopaminergic neurons; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling in development and disease ; Alzheimer's disease; Neurogenesis regulation in the olfactory epithelium; DNA damage response" "NPAS4 regulates expression of target genes; NGF-stimulated transcription; Regulation of TP53 Activity through Phosphorylation; Factors involved in megakaryocyte development and platelet production; CRMPs in Sema3A signaling; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; DARPP-32 events; Activated NTRK2 signals through CDK5" "16" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2771631356277906494" "False" "High" "IsMasterProtein" "Q01650" "Large neutral amino acids transporter small subunit 1 OS=Homo sapiens OX=9606 GN=SLC7A5 PE=1 SV=2" "0.000" "False" "7.091" "4" "1" "1" "1" "507" "55.0" "7.72" "4.81" "1" "stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf13520" "8140" "ENSG00000103257" "SLC7A5" "hsa:8140; Q01650; Q8IV97; Q9UBN8; Q9UP15; Q9UQC0" "Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Pleural mesothelioma" "Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane" "7" "0" "1.080" "0.859" "0.432" "1.063" "1.236" "0.777" "1.167" "1.122" "0.558" "28.0" "30.2" "24.0" "12.1" "29.7" "34.5" "21.7" "32.6" "31.4" "15.6" "" "" "" "" "" "" "" "" "" "" "16.7" "15.7" "13.3" "5.7" "13.8" "17.7" "10.1" "14.7" "17.0" "15.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3946386613732823747" "False" "High" "IsMasterProtein" "Q8WXD5" "Gem-associated protein 6 OS=Homo sapiens OX=9606 GN=GEMIN6 PE=1 SV=1" "0.000" "False" "7.091" "14" "2" "2" "2" "167" "18.8" "5.12" "6.86" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf06372, Pf20417" "79833" "ENSG00000152147" "GEMIN6" "B2RDP8; hsa:79833; Q53SI5; Q8WVB4; Q8WXD5; Q9H5G6" "" "SARS-CoV-2 modulates host translation machinery; snRNP Assembly" "2" "0" "0.793" "0.873" "1.278" "1.067" "0.917" "1.046" "0.783" "0.920" "0.950" "50.0" "39.6" "43.6" "63.9" "53.3" "45.9" "52.3" "39.1" "46.0" "47.5" "" "" "" "" "" "" "" "" "" "" "29.9" "20.6" "24.2" "30.0" "24.7" "23.5" "24.3" "17.6" "25.0" "47.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2735556346422021928" "False" "High" "IsMasterProtein" "P53384" "Cytosolic Fe-S cluster assembly factor NUBP1 OS=Homo sapiens OX=9606 GN=NUBP1 PE=1 SV=2" "0.000" "False" "7.077" "8" "3" "4" "3" "320" "34.5" "5.33" "10.92" "3" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10609" "4682" "ENSG00000103274" "NUBP1" "hsa:4682; P53384; Q32M30; Q498A9; Q53FS7" "Iron-sulfur cluster biogenesis" "Cytosolic iron-sulfur cluster assembly" "2" "0" "1.012" "0.971" "1.115" "0.916" "0.978" "1.039" "1.106" "1.078" "1.093" "306.4" "310.0" "297.5" "341.7" "280.8" "299.6" "318.3" "338.8" "330.2" "334.9" "" "" "" "" "" "" "" "" "" "" "183.3" "161.1" "164.7" "160.4" "130.1" "153.4" "148.0" "152.1" "179.1" "334.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6076185631256904569" "False" "High" "IsMasterProtein" "Q9P016" "Thymocyte nuclear protein 1 OS=Homo sapiens OX=9606 GN=THYN1 PE=1 SV=1" "0.000" "False" "7.066" "9" "2" "2" "2" "225" "25.7" "9.25" "4.99" "2" "" "" "" "Pf01878" "29087" "ENSG00000151500" "THYN1" "hsa:29087; Q567Q2; Q9H3L4; Q9HC20; Q9P016" "" "" "0" "0" "1.072" "1.154" "1.113" "1.251" "1.071" "1.007" "0.929" "1.027" "4.099" "107.8" "115.5" "124.4" "119.9" "134.8" "115.4" "108.5" "100.1" "110.7" "441.8" "" "" "" "" "" "" "" "" "" "" "64.5" "60.0" "68.9" "56.3" "62.5" "59.1" "50.5" "44.9" "60.1" "441.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5304133680658965036" "False" "High" "IsMasterProtein" "Q16629" "Serine/arginine-rich splicing factor 7 OS=Homo sapiens OX=9606 GN=SRSF7 PE=1 SV=1" "0.000" "False" "7.053" "15" "3" "6" "2" "238" "27.4" "11.82" "10.06" "3" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6432" "ENSG00000115875" "SRSF7" "B4DLU6; G5E9M3; hsa:6432; Q16629; Q564D3" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "7" "0" "1.010" "1.060" "0.974" "0.998" "1.032" "1.444" "1.076" "0.820" "0.857" "32.3" "32.6" "34.2" "31.4" "32.2" "33.3" "46.6" "34.7" "26.5" "27.6" "" "" "" "" "" "" "" "" "" "" "19.3" "16.9" "18.9" "14.7" "14.9" "17.0" "21.7" "15.6" "14.4" "27.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3075207303668690710" "False" "High" "IsMasterProtein" "P37198" "Nuclear pore glycoprotein p62 OS=Homo sapiens OX=9606 GN=NUP62 PE=1 SV=3" "0.000" "False" "7.035" "5" "2" "2" "2" "522" "53.2" "5.31" "6.26" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05064" "23636" "ENSG00000213024" "NUP62" "B3KWU5; hsa:23636; P37198; Q503A4; Q6GTM2; Q96C43; Q9NSL1" "7q11.23 copy number variation syndrome" "Regulation of HSF1-mediated heat shock response; Nuclear Pore Complex (NPC) Disassembly; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "30" "0" "1.007" "1.202" "0.815" "1.177" "0.687" "0.837" "1.004" "0.991" "1.824" "23.2" "23.4" "27.9" "18.9" "27.3" "15.9" "19.4" "23.3" "23.0" "42.3" "" "" "" "" "" "" "" "" "" "" "13.9" "12.1" "15.4" "8.9" "12.7" "8.2" "9.0" "10.5" "12.5" "42.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8826261878749587371" "False" "High" "IsMasterProtein" "P39023" "Large ribosomal subunit protein uL3 OS=Homo sapiens OX=9606 GN=RPL3 PE=1 SV=2" "0.000" "False" "7.034" "9" "4" "7" "4" "403" "46.1" "10.18" "9.03" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00297" "6122" "ENSG00000100316" "RPL3" "B2RDV9; hsa:6122; P39023; Q15548; Q5I0G0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3945672141617060885" "False" "High" "IsMasterProtein" "Q9P2E9" "Ribosome-binding protein 1 OS=Homo sapiens OX=9606 GN=RRBP1 PE=1 SV=5" "0.000" "False" "7.016" "2" "2" "2" "2" "1410" "152.4" "8.60" "4.90" "2" "protein metabolism;other metabolic processes;transport" "other membranes;ER/Golgi;translational apparatus" "other molecular function" "Pf05104" "6238" "ENSG00000125844" "RRBP1" "A0A0A0MRV0; A2A2S6; A6NCN6; hsa:6238; O75300; O75301; Q5W165; Q96SB2; Q9BWP1; Q9H476; Q9P2E9" "Ectoderm differentiation" "Signaling by ALK fusions and activated point mutants" "2" "0" "1.281" "1.197" "1.273" "1.147" "1.169" "1.340" "1.508" "1.377" "0.826" "56.2" "72.0" "67.3" "71.6" "64.5" "65.8" "75.3" "84.8" "77.4" "46.5" "" "" "" "" "" "" "" "" "" "" "33.7" "37.4" "37.3" "33.6" "29.9" "33.7" "35.0" "38.1" "42.0" "46.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7938684201688622214" "False" "High" "IsMasterProtein" "Q8NC96" "Adaptin ear-binding coat-associated protein 1 OS=Homo sapiens OX=9606 GN=NECAP1 PE=1 SV=2" "0.000" "False" "7.014" "11" "3" "3" "3" "275" "29.7" "6.80" "2.36" "3" "transport" "other membranes;cytosol" "" "Pf07933" "25977" "ENSG00000089818" "NECAP1" "hsa:25977; Q2NL73; Q5XG95; Q6NWY6; Q8N153; Q8NC96; Q8NCB0; Q9BU52; Q9Y407" "" "Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis" "3" "0" "1.037" "1.145" "1.148" "1.333" "1.041" "1.069" "1.209" "1.128" "1.052" "120.4" "124.9" "137.9" "138.2" "160.5" "125.4" "128.7" "145.6" "135.8" "126.7" "" "" "" "" "" "" "" "" "" "" "72.1" "64.9" "76.4" "64.9" "74.4" "64.2" "59.8" "65.3" "73.7" "126.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8890760883318771042" "False" "High" "IsMasterProtein" "Q15653" "NF-kappa-B inhibitor beta OS=Homo sapiens OX=9606 GN=NFKBIB PE=1 SV=2" "0.000" "False" "7.000" "7" "2" "2" "2" "356" "37.7" "4.84" "5.72" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00023, Pf13637" "4793" "ENSG00000104825; ENSG00000282905" "NFKBIB" "A8K3F4; hsa:4793; Q15653; Q96BJ7" "IL-1 signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-17 signaling pathway; TNF-alpha signaling pathway; Apoptosis; Novel intracellular components of RIG-I-like receptor pathway; Chemokine signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Toll-like receptor signaling pathway" "Activation of NF-kappaB in B cells; RIP-mediated NFkB activation via ZBP1; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation" "16" "0" "0.901" "1.329" "1.296" "1.512" "1.502" "1.288" "0.678" "0.839" "4.824" "19.2" "17.3" "25.5" "24.9" "29.0" "28.8" "24.7" "13.0" "16.1" "92.5" "" "" "" "" "" "" "" "" "" "" "11.5" "9.0" "14.1" "11.7" "13.4" "14.7" "11.5" "5.8" "8.7" "92.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5277181117143708744" "False" "High" "IsMasterProtein" "P60866" "Small ribosomal subunit protein uS10 OS=Homo sapiens OX=9606 GN=RPS20 PE=1 SV=1" "0.000" "False" "6.998" "19" "2" "3" "2" "119" "13.4" "9.94" "10.36" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00338" "6224" "ENSG00000008988" "RPS20" "B2R4F4; B4DW28; hsa:6224; P17075; P60866; Q5M8S9" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.981" "0.968" "1.117" "1.134" "1.171" "1.019" "0.985" "1.200" "1.292" "210.0" "206.0" "203.3" "234.6" "238.2" "245.8" "213.9" "206.8" "252.0" "271.3" "" "" "" "" "" "" "" "" "" "" "125.7" "107.0" "112.6" "110.2" "110.4" "125.8" "99.4" "92.9" "136.7" "271.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7152432727454643144" "False" "High" "IsMasterProtein" "Q6PII3" "Coiled-coil domain-containing protein 174 OS=Homo sapiens OX=9606 GN=CCDC174 PE=1 SV=3" "0.000" "False" "6.992" "5" "3" "3" "3" "467" "53.9" "6.33" "5.31" "3" "" "nucleus" "" "Pf13300" "51244" "ENSG00000154781" "CCDC174" "hsa:51244; Q6PII3; Q96CS5" "" "" "0" "0" "0.939" "0.943" "1.076" "0.937" "1.024" "1.189" "1.087" "0.882" "0.714" "104.3" "98.0" "98.3" "112.2" "97.7" "106.8" "124.0" "113.3" "92.0" "74.4" "" "" "" "" "" "" "" "" "" "" "62.4" "50.9" "54.5" "52.7" "45.3" "54.7" "57.7" "50.9" "49.9" "74.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1756895692335459560" "False" "High" "IsMasterProtein" "O95865" "Putative hydrolase DDAH2 OS=Homo sapiens OX=9606 GN=DDAH2 PE=1 SV=1" "0.000" "False" "6.983" "6" "2" "2" "2" "285" "29.6" "6.01" "5.72" "2" "other metabolic processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "" "23564" "ENSG00000206395; ENSG00000213722; ENSG00000225635; ENSG00000226634; ENSG00000227317; ENSG00000228128; ENSG00000233076" "DDAH2" "A2BEZ7; hsa:23564; O95865" "Nitric oxide metabolism in cystic fibrosis" "" "1" "0" "1.368" "1.016" "1.105" "0.957" "1.132" "1.256" "1.114" "1.314" "0.787" "85.0" "116.3" "86.4" "94.0" "81.3" "96.2" "106.8" "94.8" "111.8" "66.9" "" "" "" "" "" "" "" "" "" "" "50.9" "60.5" "47.9" "44.1" "37.7" "49.3" "49.7" "42.5" "60.6" "66.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4577230366185343110" "False" "High" "IsMasterProtein" "Q96GM8" "Target of EGR1 protein 1 OS=Homo sapiens OX=9606 GN=TOE1 PE=1 SV=1" "0.000" "False" "6.981" "8" "3" "3" "3" "510" "56.5" "7.18" "5.19" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf04857" "114034" "ENSG00000132773" "TOE1" "B4DEM6; hsa:114034; Q6IA35; Q8IWN5; Q96GM8; Q9H846" "" "" "0" "0" "0.821" "0.880" "0.881" "0.993" "0.879" "0.977" "0.831" "0.979" "1.082" "72.3" "59.3" "63.6" "63.7" "71.8" "63.5" "70.6" "60.0" "70.7" "78.2" "" "" "" "" "" "" "" "" "" "" "43.2" "30.8" "35.2" "29.9" "33.3" "32.5" "32.8" "26.9" "38.4" "78.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8788472230308956" "False" "High" "IsMasterProtein" "Q8NCW5" "NAD(P)H-hydrate epimerase OS=Homo sapiens OX=9606 GN=NAXE PE=1 SV=2" "0.000" "False" "6.945" "12" "3" "5" "3" "288" "31.7" "7.66" "6.89" "3" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;mitochondrion;other cell component" "other molecular function" "Pf03853" "128240" "ENSG00000163382" "NAXE" "B4DGY3; hsa:128240; Q496C6; Q5T3I2; Q8NCW5" "" "Nicotinamide salvaging" "1" "0" "1.002" "0.977" "0.858" "0.960" "1.066" "0.842" "1.108" "1.017" "0.633" "91.5" "91.7" "89.3" "78.5" "87.8" "97.4" "77.0" "101.3" "93.0" "57.9" "" "" "" "" "" "" "" "" "" "" "54.7" "47.6" "49.5" "36.8" "40.7" "49.9" "35.8" "45.5" "50.5" "57.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8657288411045177937" "False" "High" "IsMasterProtein" "O95429" "BAG family molecular chaperone regulator 4 OS=Homo sapiens OX=9606 GN=BAG4 PE=1 SV=1" "0.000" "False" "6.929" "7" "2" "2" "2" "457" "49.6" "5.12" "5.07" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf02179" "9530" "ENSG00000156735" "BAG4" "B4E217; hsa:9530; O95429; O95818" "Oxidative damage response" "Regulation of HSF1-mediated heat shock response; Signaling by FGFR1 in disease; Signaling by plasma membrane FGFR1 fusions; TNF signaling" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5713044218766232811" "False" "High" "IsMasterProtein" "Q9NXR7" "BRISC and BRCA1-A complex member 2 OS=Homo sapiens OX=9606 GN=BABAM2 PE=1 SV=2" "0.000" "False" "6.921" "6" "2" "2" "2" "383" "43.5" "5.81" "5.94" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf06113" "9577" "ENSG00000158019" "BABAM2" "A8K4X1; D6W562; D6W563; hsa:9577; Q13880; Q4ZFX8; Q53SD0; Q969X9; Q96P06; Q9NXR7" "5q35 copy number variation" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Nonhomologous End-Joining (NHEJ)" "6" "0" "1.084" "0.978" "0.936" "1.023" "1.035" "1.112" "0.978" "0.915" "0.821" "120.0" "130.2" "117.3" "112.3" "122.8" "124.3" "133.5" "117.4" "109.9" "98.6" "" "" "" "" "" "" "" "" "" "" "71.8" "67.6" "65.0" "52.7" "56.9" "63.6" "62.1" "52.7" "59.6" "98.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5882151393090730100" "False" "High" "IsMasterProtein" "Q8TA86" "Retinitis pigmentosa 9 protein OS=Homo sapiens OX=9606 GN=RP9 PE=1 SV=2" "0.000" "False" "6.912" "8" "2" "3" "2" "221" "26.1" "9.79" "8.81" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "" "6100" "ENSG00000164610" "RP9" "hsa:6100; Q8TA86" "" "" "0" "0" "1.136" "1.096" "1.064" "1.106" "0.944" "1.275" "1.177" "1.235" "0.314" "34.6" "39.3" "37.9" "36.8" "38.3" "32.7" "44.2" "40.7" "42.8" "10.9" "" "" "" "" "" "" "" "" "" "" "20.7" "20.4" "21.0" "17.3" "17.7" "16.7" "20.5" "18.3" "23.2" "10.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4353457585173966729" "False" "High" "IsMasterProtein" "P84101" "Small EDRK-rich factor 2 OS=Homo sapiens OX=9606 GN=SERF2 PE=1 SV=1" "0.000" "False" "6.911" "17" "2" "5" "2" "59" "6.9" "10.45" "11.63" "2" "other biological processes" "cytosol;nucleus" "" "Pf04419" "10169" "ENSG00000140264" "SERF2" "A6NL45; B5MCG1; B9A026; hsa:10169; O75918; O88891; P84101; Q9BZH7" "" "" "0" "0" "0.941" "1.052" "0.863" "1.066" "0.858" "1.052" "0.936" "0.705" "0.398" "201.5" "189.6" "212.0" "173.8" "214.8" "172.8" "211.9" "188.6" "142.1" "80.1" "" "" "" "" "" "" "" "" "" "" "120.6" "98.5" "117.4" "81.6" "99.6" "88.4" "98.5" "84.7" "77.1" "80.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2170038667873591835" "False" "High" "IsMasterProtein" "O15027" "Protein transport protein Sec16A OS=Homo sapiens OX=9606 GN=SEC16A PE=1 SV=4" "0.000" "False" "6.911" "1" "3" "3" "3" "2357" "251.7" "5.80" "3.65" "3" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "" "Pf12931, Pf12932" "9919" "ENSG00000148396" "SEC16A" "A1YCA4; hsa:9919; J3KNL6; O15027; Q4G0D7; Q5SXP0; Q5SXP1; Q8N347; Q96HP1" "" "COPII-mediated vesicle transport" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2222501069186758979" "False" "High" "IsMasterProtein" "Q86W42" "THO complex subunit 6 homolog OS=Homo sapiens OX=9606 GN=THOC6 PE=1 SV=1" "0.000" "False" "6.905" "7" "2" "5" "2" "341" "37.5" "7.43" "13.22" "2" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00400" "79228" "ENSG00000131652" "THOC6" "B2RA85; hsa:79228; Q86W42; Q8NBR1; Q9BTV9" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "1.020" "1.029" "1.120" "1.153" "1.231" "1.181" "1.006" "1.095" "2.032" "199.1" "203.2" "204.8" "223.1" "229.6" "245.1" "235.3" "200.4" "218.2" "404.7" "" "" "" "" "" "" "" "" "" "" "119.2" "105.6" "113.4" "104.7" "106.4" "125.5" "109.4" "90.0" "118.4" "404.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3276103228213200498" "False" "High" "IsMasterProtein" "P62308" "Small nuclear ribonucleoprotein G OS=Homo sapiens OX=9606 GN=SNRPG PE=1 SV=1" "0.000" "False" "6.899" "25" "2" "9" "2" "76" "8.5" "8.88" "20.08" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6637" "ENSG00000143977" "SNRPG" "D6W5G6; hsa:6637; P62308; Q15357; Q6IB86" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; RNA Polymerase II Transcription Termination; snRNP Assembly; SARS-CoV-2 modulates host translation machinery; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "0.818" "0.926" "0.994" "0.943" "0.988" "0.993" "0.953" "0.892" "0.567" "418.1" "342.2" "387.2" "415.5" "394.3" "413.3" "415.2" "398.6" "373.0" "237.1" "" "" "" "" "" "" "" "" "" "" "250.2" "177.8" "214.4" "195.1" "182.8" "211.6" "193.1" "179.0" "202.4" "237.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-273580326344755001" "False" "High" "IsMasterProtein" "P26885" "Peptidyl-prolyl cis-trans isomerase FKBP2 OS=Homo sapiens OX=9606 GN=FKBP2 PE=1 SV=2" "0.000" "False" "6.882" "8" "1" "2" "1" "142" "15.6" "9.13" "6.36" "1" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00254" "2286" "ENSG00000173486" "FKBP2" "hsa:2286; P26885; Q5BJH9; Q9BTS7" "Complement system" "" "1" "0" "1.051" "0.809" "0.615" "1.112" "0.878" "1.007" "0.889" "0.991" "0.696" "41.9" "44.1" "33.9" "25.8" "46.6" "36.8" "42.2" "37.3" "41.6" "29.2" "" "" "" "" "" "" "" "" "" "" "25.1" "22.9" "18.8" "12.1" "21.6" "18.8" "19.6" "16.7" "22.6" "29.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3910954529377130988" "False" "High" "IsMasterProtein" "Q9UPN3" "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 OS=Homo sapiens OX=9606 GN=MACF1 PE=1 SV=4" "0.000" "False" "6.881" "1" "3" "3" "3" "7388" "837.8" "5.39" "5.35" "3" "cell-cell signaling;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf00681, Pf02187, Pf13499, Pf17902, Pf18373, Pf21019, Pf21020, Pf21097" "23499" "ENSG00000127603" "MACF1" "B1ALC5; E9PJT0; hsa:23499; O75053; Q5VW20; Q8WXY1; Q8WXY2; Q96PK2; Q9H540; Q9UKP0; Q9ULG9; Q9UPN3" "Mesodermal commitment pathway; Mesodermal commitment pathway" "" "2" "0" "1.018" "1.093" "0.905" "1.122" "0.954" "1.134" "1.080" "1.037" "0.919" "106.9" "108.8" "116.8" "96.7" "119.9" "102.0" "121.2" "115.4" "110.8" "98.2" "" "" "" "" "" "" "" "" "" "" "64.0" "56.5" "64.7" "45.4" "55.6" "52.2" "56.3" "51.8" "60.1" "98.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1677934760849169098" "False" "High" "IsMasterProtein" "Q8IVH4" "Methylmalonic aciduria type A protein, mitochondrial OS=Homo sapiens OX=9606 GN=MMAA PE=1 SV=1" "0.000" "False" "6.879" "5" "2" "2" "2" "418" "46.5" "9.29" "6.15" "2" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf03308" "166785" "ENSG00000151611" "MMAA" "B3KX40; hsa:166785; Q495G7; Q8IVH4" "" "Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM; Cobalamin (Cbl) metabolism" "4" "0" "1.194" "0.972" "1.429" "1.138" "1.200" "1.360" "1.222" "1.046" "1.104" "73.3" "87.6" "71.3" "104.8" "83.5" "88.0" "99.7" "89.6" "76.7" "80.9" "" "" "" "" "" "" "" "" "" "" "43.9" "45.5" "39.5" "49.2" "38.7" "45.0" "46.4" "40.2" "41.6" "80.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2652497111054879184" "False" "High" "IsMasterProtein" "Q96HE7" "ERO1-like protein alpha OS=Homo sapiens OX=9606 GN=ERO1A PE=1 SV=2" "0.000" "False" "6.849" "6" "2" "3" "2" "468" "54.4" "5.68" "6.81" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf04137" "30001" "ENSG00000197930" "ERO1A" "A8K9X4; A8MYW1; hsa:30001; Q7LD45; Q96HE7; Q9P1Q9; Q9UKV6" "" "Detoxification of Reactive Oxygen Species" "1" "0" "1.848" "1.837" "1.890" "2.056" "1.593" "2.243" "2.086" "1.975" "4.712" "13.9" "25.8" "25.6" "26.4" "28.7" "22.2" "31.3" "29.1" "27.5" "65.7" "" "" "" "" "" "" "" "" "" "" "8.3" "13.4" "14.2" "12.4" "13.3" "11.4" "14.5" "13.1" "14.9" "65.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2149131157478544716" "False" "High" "IsMasterProtein" "Q6P587" "Oxaloacetate tautomerase FAHD1, mitochondrial OS=Homo sapiens OX=9606 GN=FAHD1 PE=1 SV=3" "0.000" "False" "6.844" "13" "3" "4" "3" "221" "24.5" "7.39" "10.33" "3" "" "" "" "" "" "" "" "" "" "" "0" "0" "1.178" "1.228" "1.834" "1.256" "1.208" "1.180" "1.536" "1.390" "0.767" "41.9" "49.4" "51.5" "76.9" "52.6" "50.6" "49.5" "64.4" "58.2" "32.1" "" "" "" "" "" "" "" "" "" "" "25.1" "25.7" "28.5" "36.1" "24.4" "25.9" "23.0" "28.9" "31.6" "32.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1684474116770674977" "False" "High" "IsMasterProtein" "Q9NW68" "BSD domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BSDC1 PE=1 SV=1" "0.000" "False" "6.839" "7" "3" "4" "3" "430" "47.1" "4.49" "8.41" "3" "" "other cell component" "" "Pf03909" "55108" "ENSG00000160058" "BSDC1" "B4DMS7; B4DTI7; B4DTP7; B4E2X8; hsa:55108; Q49AT8; Q68DY6; Q6IAA3; Q6MZK1; Q6UXS1; Q9HAL9; Q9NW68" "" "" "0" "0" "0.973" "0.958" "1.148" "1.160" "0.993" "1.386" "1.185" "0.932" "0.880" "78.1" "76.0" "74.8" "89.7" "90.6" "77.5" "108.2" "92.6" "72.8" "68.8" "" "" "" "" "" "" "" "" "" "" "46.7" "39.5" "41.4" "42.1" "42.0" "39.7" "50.3" "41.6" "39.5" "68.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7247108035044904633" "False" "High" "IsMasterProtein" "P62244" "Small ribosomal subunit protein uS8 OS=Homo sapiens OX=9606 GN=RPS15A PE=1 SV=2" "0.000" "False" "6.837" "17" "2" "2" "2" "130" "14.8" "10.13" "6.19" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00410" "6210" "ENSG00000134419" "RPS15A" "hsa:6210; P39027; P39031; P62244; Q3MHD9; Q8C023; Q9BV24" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.845" "0.937" "0.949" "0.955" "0.960" "1.194" "1.091" "1.067" "1.182" "59.4" "50.2" "55.6" "56.4" "56.8" "57.0" "70.9" "64.8" "63.4" "70.2" "" "" "" "" "" "" "" "" "" "" "35.6" "26.1" "30.8" "26.5" "26.3" "29.2" "33.0" "29.1" "34.4" "70.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8961190954250988131" "False" "High" "IsMasterProtein" "Q16891" "MICOS complex subunit MIC60 OS=Homo sapiens OX=9606 GN=IMMT PE=1 SV=1" "0.000" "False" "6.829" "3" "3" "3" "3" "758" "83.6" "6.48" "4.68" "3" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "" "Pf09731" "10989" "ENSG00000132305" "IMMT" "B1H0U5; B2R5N6; hsa:10989; Q14539; Q15092; Q16891; Q68D41; Q69HW5; Q6IBL0; Q7Z3X1; Q8TAJ5; Q9P0V2" "" "Cristae formation" "1" "0" "0.974" "0.798" "0.947" "0.979" "0.963" "0.946" "0.944" "1.009" "0.260" "217.1" "211.5" "173.2" "205.5" "212.6" "209.1" "205.5" "204.9" "219.0" "56.4" "" "" "" "" "" "" "" "" "" "" "129.9" "109.9" "95.9" "96.5" "98.6" "107.0" "95.5" "92.0" "118.8" "56.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8470194220236547975" "False" "High" "IsMasterProtein" "Q5TBB1" "Ribonuclease H2 subunit B OS=Homo sapiens OX=9606 GN=RNASEH2B PE=1 SV=1" "0.000" "False" "6.819" "5" "2" "4" "2" "312" "35.1" "9.13" "10.04" "2" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf09468, Pf17745" "79621" "ENSG00000136104" "RNASEH2B" "G3XAJ1; hsa:79621; Q05DR2; Q5TBB1; Q6PK48; Q9HAF7" "" "" "0" "0" "1.086" "0.957" "1.039" "1.099" "1.100" "1.016" "0.153" "1.375" "10.829" "52.1" "56.6" "49.9" "54.2" "57.3" "57.4" "53.0" "8.0" "71.7" "564.5" "" "" "" "" "" "" "" "" "" "" "31.2" "29.4" "27.6" "25.4" "26.6" "29.4" "24.6" "3.6" "38.9" "564.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "968979890096343817" "False" "High" "IsMasterProtein" "P53611" "Geranylgeranyl transferase type-2 subunit beta OS=Homo sapiens OX=9606 GN=RABGGTB PE=1 SV=2" "0.000" "False" "6.805" "8" "3" "3" "3" "331" "36.9" "5.03" "6.54" "3" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00432" "5876" "ENSG00000137955" "RABGGTB" "hsa:5876; P53611; Q92697" "" "RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "2" "0" "1.059" "0.988" "1.105" "1.240" "1.157" "1.093" "1.046" "1.023" "1.295" "65.8" "69.6" "65.0" "72.7" "81.6" "76.1" "71.8" "68.8" "67.3" "85.2" "" "" "" "" "" "" "" "" "" "" "39.3" "36.2" "36.0" "34.1" "37.8" "38.9" "33.4" "30.9" "36.5" "85.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4597913287802266182" "False" "High" "IsMasterProtein" "O60921" "Checkpoint protein HUS1 OS=Homo sapiens OX=9606 GN=HUS1 PE=1 SV=1" "0.000" "False" "6.800" "9" "2" "3" "2" "280" "31.7" "6.84" "5.78" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04005" "3364" "ENSG00000136273" "HUS1" "B4DFI9; hsa:3364; O60921" "ATR signaling" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "8" "0" "1.058" "0.985" "0.981" "1.131" "1.056" "1.196" "1.128" "1.150" "0.925" "112.0" "118.5" "110.3" "109.9" "126.7" "118.2" "133.9" "126.3" "128.8" "103.5" "" "" "" "" "" "" "" "" "" "" "67.0" "61.6" "61.1" "51.6" "58.7" "60.5" "62.3" "56.7" "69.9" "103.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2854050072506968056" "False" "High" "IsMasterProtein" "P29372" "DNA-3-methyladenine glycosylase OS=Homo sapiens OX=9606 GN=MPG PE=1 SV=3" "0.000" "False" "6.790" "11" "3" "3" "3" "298" "32.8" "9.57" "7.84" "3" "DNA metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf02245" "4350" "ENSG00000103152" "MPG" "G5E9E2; hsa:4350; P29372; Q13770; Q15275; Q15961; Q5J9I4; Q96BZ6; Q96S33; Q9NNX5" "Base excision repair; DNA repair pathways, full network" "Recognition and association of DNA glycosylase with site containing an affected purine; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1" "5" "0" "1.261" "0.853" "1.201" "1.069" "1.211" "1.079" "0.894" "0.863" "1.142" "74.7" "94.2" "63.7" "89.7" "79.8" "90.4" "80.6" "66.7" "64.4" "85.2" "" "" "" "" "" "" "" "" "" "" "44.7" "48.9" "35.3" "42.1" "37.0" "46.3" "37.5" "30.0" "35.0" "85.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3035595102958398127" "False" "High" "IsMasterProtein" "P46777" "Large ribosomal subunit protein uL18 OS=Homo sapiens OX=9606 GN=RPL5 PE=1 SV=3" "0.000" "False" "6.786" "9" "3" "3" "3" "297" "34.3" "9.72" "8.24" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf14204, Pf17144" "6125" "ENSG00000122406" "RPL5" "hsa:6125; P46777; Q32LZ3; Q53HH6; Q9H3F4" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.218" "0.979" "0.897" "1.023" "1.461" "1.207" "1.259" "1.382" "1.384" "28.0" "34.1" "27.4" "25.1" "28.7" "40.9" "33.8" "35.3" "38.7" "38.8" "" "" "" "" "" "" "" "" "" "" "16.8" "17.7" "15.2" "11.8" "13.3" "21.0" "15.7" "15.8" "21.0" "38.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7873984446358378188" "False" "High" "IsMasterProtein" "Q6UUV9" "CREB-regulated transcription coactivator 1 OS=Homo sapiens OX=9606 GN=CRTC1 PE=1 SV=2" "0.000" "False" "6.772" "4" "2" "2" "2" "634" "67.3" "6.05" "2.76" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12884, Pf12885, Pf12886" "23373" "ENSG00000105662" "CRTC1" "A6NMG5; hsa:23373; O75114; Q6UUV9; Q6Y3A3; Q7LDZ2; Q8IUL3; Q8IZ34; Q8IZL1; Q8N6W3; Q96AI8; Q9H801" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Mesodermal commitment pathway" "Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1450891647387080638" "False" "High" "IsMasterProtein" "Q9BUL8" "Programmed cell death protein 10 OS=Homo sapiens OX=9606 GN=PDCD10 PE=1 SV=1" "0.000" "False" "6.762" "10" "2" "6" "2" "212" "24.7" "8.19" "15.28" "2" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf06840, Pf20929" "11235" "ENSG00000114209" "PDCD10" "A8K515; D3DNN5; hsa:11235; O14811; Q9BUL8" "" "" "0" "0" "1.000" "0.914" "0.960" "1.064" "0.945" "1.156" "0.948" "0.991" "1.081" "438.1" "438.2" "400.4" "420.4" "466.0" "414.2" "506.5" "415.5" "434.4" "473.6" "" "" "" "" "" "" "" "" "" "" "262.2" "227.7" "221.8" "197.4" "216.0" "212.0" "235.5" "186.5" "235.7" "473.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8588470506095453677" "False" "High" "IsMasterProtein" "P21912" "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHB PE=1 SV=3" "0.000" "False" "6.762" "10" "3" "4" "3" "280" "31.6" "8.76" "5.95" "3" "other metabolic processes" "plasma membrane;other membranes;mitochondrion;nucleus" "other molecular function" "Pf13085, Pf13534" "6390" "ENSG00000117118" "SDHB" "B2R545; hsa:6390; P21912; Q0QEY7; Q9NQ12" "Electron transport chain: OXPHOS system in mitochondria; Metabolic reprogramming in colon cancer; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; TCA cycle (aka Krebs or citric acid cycle)" "Respiratory electron transport; Citric acid cycle (TCA cycle)" "7" "0" "1.249" "1.422" "1.164" "1.356" "1.226" "1.164" "1.193" "1.325" "1.275" "126.8" "158.3" "180.2" "147.6" "171.9" "155.4" "147.6" "151.2" "168.0" "161.7" "" "" "" "" "" "" "" "" "" "" "75.9" "82.3" "99.8" "69.3" "79.7" "79.6" "68.6" "67.9" "91.1" "161.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2750317325017084074" "False" "High" "IsMasterProtein" "Q12962" "Transcription initiation factor TFIID subunit 10 OS=Homo sapiens OX=9606 GN=TAF10 PE=1 SV=1" "0.000" "False" "6.744" "15" "2" "2" "2" "218" "21.7" "6.57" "4.95" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03540" "6881" "ENSG00000166337" "TAF10" "hsa:6881; O00703; Q12962; Q13175; Q6FH13" "" "HATs acetylate histones; Ub-specific processing proteases; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8978349436204480078" "False" "High" "IsMasterProtein" "Q13148" "TAR DNA-binding protein 43 OS=Homo sapiens OX=9606 GN=TARDBP PE=1 SV=1" "0.000" "False" "6.741" "4" "2" "3" "2" "414" "44.7" "6.19" "4.51" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf18694, Pf20910" "23435" "ENSG00000120948" "TARDBP" "A4GUK4; A4GUK5; A4GUK6; B2R629; B4DJ45; E2PU12; hsa:23435; Q13148; Q53H27; Q6FI92; Q96DJ0" "MECP2 and associated Rett syndrome; HDAC6 interactions in the central nervous system" "" "2" "0" "0.793" "0.977" "1.264" "1.351" "1.019" "0.834" "0.010" "1.009" "14.041" "66.8" "52.9" "65.2" "84.4" "90.2" "68.0" "55.7" "0.0" "67.4" "937.5" "" "" "" "" "" "" "" "" "" "" "40.0" "27.5" "36.1" "39.6" "41.8" "34.8" "25.9" "0.0" "36.6" "937.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1246779234316334068" "False" "High" "IsMasterProtein" "P49773" "Adenosine 5'-monophosphoramidase HINT1 OS=Homo sapiens OX=9606 GN=HINT1 PE=1 SV=2" "0.000" "False" "6.741" "13" "2" "9" "2" "126" "13.8" "6.95" "25.72" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01230" "3094" "ENSG00000169567" "HINT1" "hsa:3094; P49773; Q9H5W8" "" "" "0" "0" "1.121" "1.034" "1.171" "1.142" "1.042" "1.244" "1.144" "1.016" "0.661" "924.4" "1036.4" "955.5" "1082.9" "1055.8" "963.6" "1149.7" "1057.9" "939.2" "610.7" "" "" "" "" "" "" "" "" "" "" "553.2" "538.6" "529.2" "508.4" "489.4" "493.3" "534.6" "474.9" "509.5" "610.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8791134701989231462" "False" "High" "IsMasterProtein" "Q9UQ13" "Leucine-rich repeat protein SHOC-2 OS=Homo sapiens OX=9606 GN=SHOC2 PE=1 SV=2" "0.000" "False" "6.739" "5" "3" "3" "3" "582" "64.8" "8.46" "2.44" "3" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13855" "8036" "ENSG00000108061" "SHOC2" "A8K9W8; B3KR23; hsa:8036; O76063; Q5VZS8; Q5VZS9; Q9UQ13" "Ras signaling; 22q11.2 copy number variation syndrome; Autophagy in pancreatic ductal adenocarcinoma" "RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling" "6" "0" "1.276" "1.016" "0.950" "0.927" "1.168" "1.070" "0.932" "1.118" "2.128" "76.5" "97.6" "77.7" "72.7" "70.9" "89.3" "81.8" "71.3" "85.5" "162.7" "" "" "" "" "" "" "" "" "" "" "45.8" "50.7" "43.0" "34.1" "32.8" "45.7" "38.0" "32.0" "46.4" "162.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5762449723745155897" "False" "High" "IsMasterProtein" "Q9H5V9" "STING ER exit protein OS=Homo sapiens OX=9606 GN=STEEP1 PE=1 SV=1" "0.000" "False" "6.737" "7" "2" "2" "2" "222" "25.6" "8.73" "6.01" "2" "cell organization and biogenesis;transport" "cytoskeleton;nucleus;other cell component" "" "" "63932" "ENSG00000018610" "STEEP1" "A8MPX7; B4DQN2; D3DWH9; F5GWL7; hsa:63932; O43351; Q9H5V9" "" "mRNA Splicing - Major Pathway" "1" "0" "1.043" "1.200" "0.997" "1.026" "1.214" "1.209" "1.199" "1.209" "1.094" "141.7" "147.8" "170.0" "141.2" "145.3" "172.0" "171.4" "169.9" "171.3" "155.0" "" "" "" "" "" "" "" "" "" "" "84.8" "76.8" "94.1" "66.3" "67.4" "88.0" "79.7" "76.3" "92.9" "155.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8196142567442196869" "False" "High" "IsMasterProtein" "P20645" "Cation-dependent mannose-6-phosphate receptor OS=Homo sapiens OX=9606 GN=M6PR PE=1 SV=1" "0.000" "False" "6.728" "10" "2" "2" "2" "277" "31.0" "5.83" "5.89" "2" "transport" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02157" "4074" "ENSG00000003056" "M6PR" "A8K528; D3DUV5; hsa:4074; P20645" "" "Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network; Glycosphingolipid catabolism" "5" "0" "1.103" "0.995" "1.192" "1.121" "1.012" "1.102" "1.146" "1.343" "1.006" "142.9" "157.7" "142.2" "170.4" "160.2" "144.7" "157.5" "163.8" "192.0" "143.8" "" "" "" "" "" "" "" "" "" "" "85.5" "81.9" "78.8" "80.0" "74.2" "74.1" "73.3" "73.6" "104.1" "143.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6418921267369266529" "False" "High" "IsMasterProtein" "P31321" "cAMP-dependent protein kinase type I-beta regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR1B PE=1 SV=4" "0.000" "False" "6.722" "7" "3" "3" "2" "381" "43.0" "5.71" "5.05" "3" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5575" "ENSG00000188191" "PRKAR1B" "hsa:5575; P31321; Q8N422" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Cannabinoid receptor signaling; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase" "21" "0" "1.084" "1.086" "0.857" "1.155" "0.814" "1.348" "0.947" "1.118" "2.720" "17.9" "19.4" "19.5" "15.4" "20.7" "14.6" "24.2" "17.0" "20.0" "48.8" "" "" "" "" "" "" "" "" "" "" "10.7" "10.1" "10.8" "7.2" "9.6" "7.5" "11.2" "7.6" "10.9" "48.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4248741172720899665" "False" "High" "IsMasterProtein" "P62304" "Small nuclear ribonucleoprotein E OS=Homo sapiens OX=9606 GN=SNRPE PE=1 SV=1" "0.000" "False" "6.716" "29" "3" "7" "3" "92" "10.8" "9.44" "13.19" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "6635" "ENSG00000182004" "SNRPE" "B2R5B9; hsa:6635; P08578; P62304; Q15498; Q5BKT2" "mRNA processing" "mRNA Splicing - Major Pathway; snRNP Assembly; RNA Polymerase II Transcription Termination; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "0.743" "0.883" "1.131" "1.205" "1.295" "1.280" "1.036" "0.781" "0.760" "22.4" "16.7" "19.8" "25.4" "27.0" "29.1" "28.7" "23.2" "17.5" "17.1" "" "" "" "" "" "" "" "" "" "" "13.4" "8.7" "11.0" "11.9" "12.5" "14.9" "13.4" "10.4" "9.5" "17.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2179808201318642480" "False" "High" "IsMasterProtein" "Cont_Q3SZR3" "Alpha-1-acid glycoprotein OS=Bos taurus OX=9913 GN=ORM1 PE=2 SV=1" "0.000" "True" "6.714" "9" "2" "2" "2" "202" "23.2" "5.87" "7.14" "2" "stress response;other biological processes" "non-structural extracellular" "" "Pf00061" "497200" "" "ORM1" "bta:497200; Q3SZR3" "" "" "0" "0" "1.269" "1.257" "1.270" "1.004" "0.949" "1.292" "1.306" "1.133" "0.696" "179.9" "228.2" "226.0" "228.4" "180.5" "170.8" "232.5" "234.9" "203.9" "125.2" "" "" "" "" "" "" "" "" "" "" "107.6" "118.6" "125.2" "107.2" "83.7" "87.4" "108.1" "105.4" "110.6" "125.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3972038562420252503" "False" "High" "IsMasterProtein" "P61254" "Large ribosomal subunit protein uL24 OS=Homo sapiens OX=9606 GN=RPL26 PE=1 SV=1" "0.000" "False" "6.704" "12" "2" "5" "2" "145" "17.2" "10.55" "13.75" "2" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00467, Pf16906" "6154" "ENSG00000161970" "RPL26" "B2R4F0; D3DTR8; hsa:6154; P61254; Q02877; Q6IPY2" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Peptide chain elongation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.018" "0.995" "1.053" "0.965" "0.928" "0.941" "0.801" "0.984" "1.960" "502.6" "511.7" "499.8" "529.4" "484.8" "466.5" "472.8" "402.5" "494.6" "985.2" "" "" "" "" "" "" "" "" "" "" "300.8" "265.9" "276.8" "248.5" "224.7" "238.8" "219.9" "180.7" "268.3" "985.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3710113209643881705" "False" "High" "IsMasterProtein" "O75794" "Translation initiation factor eIF2 assembly protein OS=Homo sapiens OX=9606 GN=CDC123 PE=1 SV=1" "0.000" "False" "6.703" "10" "4" "5" "4" "336" "39.1" "4.81" "10.11" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other cell component" "" "Pf07065" "8872" "ENSG00000151465" "CDC123" "A8JZZ7; hsa:8872; O75794; Q14107; Q5T0L4; Q5T0L5; Q5T0L7; Q5T0L8; Q5T0L9" "" "" "0" "0" "0.938" "0.883" "1.096" "1.148" "1.078" "1.165" "0.861" "1.072" "2.419" "146.7" "137.6" "129.5" "160.8" "168.4" "158.2" "170.9" "126.3" "157.3" "354.9" "" "" "" "" "" "" "" "" "" "" "87.8" "71.5" "71.7" "75.5" "78.0" "81.0" "79.5" "56.7" "85.3" "354.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3062599375234318027" "False" "High" "IsMasterProtein" "Q02447" "Transcription factor Sp3 OS=Homo sapiens OX=9606 GN=SP3 PE=1 SV=3" "0.000" "False" "6.698" "2" "1" "2" "1" "781" "81.9" "5.26" "9.33" "1" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6670" "ENSG00000172845" "SP3" "A0AVL9; B4E2B7; hsa:6670; Q02447; Q69B26; Q69B27; Q8TD56; Q8WWU4; Q9BQR1" "Selenium metabolism and selenoproteins; MECP2 and associated Rett syndrome; Non-genomic actions of 1,25 dihydroxyvitamin D3; Sudden infant death syndrome (SIDS) susceptibility pathways" "SUMOylation of transcription factors" "5" "0" "1.004" "0.990" "0.923" "1.235" "1.065" "1.065" "1.053" "0.968" "0.890" "164.6" "165.3" "163.0" "152.0" "203.4" "175.4" "175.3" "173.4" "159.3" "146.6" "" "" "" "" "" "" "" "" "" "" "98.5" "85.9" "90.2" "71.3" "94.3" "89.8" "81.5" "77.8" "86.4" "146.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1016656761563188351" "False" "High" "IsMasterProtein" "O15127" "Secretory carrier-associated membrane protein 2 OS=Homo sapiens OX=9606 GN=SCAMP2 PE=1 SV=2" "0.000" "False" "6.690" "8" "2" "2" "2" "329" "36.6" "6.10" "5.97" "2" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04144" "10066" "ENSG00000140497" "SCAMP2" "B2RDF0; hsa:10066; O15127; Q9BQE8" "Serotonin transporter activity; Monoamine transport" "" "2" "0" "1.194" "1.090" "1.313" "1.401" "1.119" "1.105" "1.065" "1.143" "1.035" "105.4" "125.8" "114.9" "138.3" "147.6" "117.9" "116.5" "112.2" "120.5" "109.0" "" "" "" "" "" "" "" "" "" "" "63.1" "65.3" "63.6" "65.0" "68.4" "60.4" "54.2" "50.4" "65.4" "109.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4989435524198560061" "False" "High" "IsMasterProtein" "P48506" "Glutamate--cysteine ligase catalytic subunit OS=Homo sapiens OX=9606 GN=GCLC PE=1 SV=2" "0.000" "False" "6.682" "4" "2" "2" "2" "637" "72.7" "6.09" "6.30" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf03074" "2729" "ENSG00000001084" "GCLC" "hsa:2729; P48506; Q14399" "Glutathione metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Aryl hydrocarbon receptor pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; One-carbon metabolism and related pathways; Oxidative stress response; Ferroptosis; NRF2-ARE regulation; Vitamin D-sensitive calcium signaling in depression; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway" "Glutathione synthesis and recycling; NFE2L2 regulating anti-oxidant/detoxification enzymes; Defective GCLC causes HAGGSD" "17" "0" "1.050" "1.163" "1.250" "1.040" "1.064" "1.065" "0.948" "1.178" "2.650" "54.2" "56.9" "63.0" "67.7" "56.3" "57.6" "57.7" "51.3" "63.8" "143.6" "" "" "" "" "" "" "" "" "" "" "32.4" "29.6" "34.9" "31.8" "26.1" "29.5" "26.8" "23.1" "34.6" "143.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3387602003086690885" "False" "High" "IsMasterProtein" "Q9BVC5" "Ashwin OS=Homo sapiens OX=9606 GN=C2orf49 PE=1 SV=1" "0.000" "False" "6.677" "7" "2" "2" "2" "232" "25.8" "9.74" "5.81" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus;other cell component" "" "Pf15323" "79074" "ENSG00000135974" "C2orf49" "B3KXN3; B4E2G9; hsa:79074; Q9BVC5" "" "tRNA processing in the nucleus" "1" "0" "1.091" "1.117" "1.282" "1.128" "1.104" "1.219" "0.945" "1.152" "3.153" "133.3" "145.3" "148.9" "170.9" "150.4" "147.1" "162.4" "125.9" "153.6" "420.2" "" "" "" "" "" "" "" "" "" "" "79.8" "75.5" "82.5" "80.2" "69.7" "75.3" "75.5" "56.5" "83.3" "420.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4988344905656775202" "False" "High" "IsMasterProtein" "Q92665" "Small ribosomal subunit protein mS31 OS=Homo sapiens OX=9606 GN=MRPS31 PE=1 SV=3" "0.000" "False" "6.675" "6" "2" "3" "2" "395" "45.3" "9.29" "2.76" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf15433" "10240" "ENSG00000102738" "MRPS31" "B2RCS3; hsa:10240; Q5VYC8; Q8WTV8; Q92665" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.417" "1.776" "1.873" "1.690" "1.523" "1.376" "1.401" "1.348" "0.970" "18.4" "26.0" "32.6" "34.4" "31.0" "27.9" "25.2" "25.7" "24.7" "17.8" "" "" "" "" "" "" "" "" "" "" "11.0" "13.5" "18.1" "16.1" "14.4" "14.3" "11.7" "11.5" "13.4" "17.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8399686422006739058" "False" "High" "IsMasterProtein" "O15116" "U6 snRNA-associated Sm-like protein LSm1 OS=Homo sapiens OX=9606 GN=LSM1 PE=1 SV=1" "0.000" "False" "6.666" "20" "2" "9" "2" "133" "15.2" "5.22" "17.50" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "27257" "ENSG00000175324" "LSM1" "B2R5E6; hsa:27257; O15116" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "1.068" "0.961" "1.064" "0.948" "1.013" "1.229" "1.080" "1.054" "0.491" "145.3" "155.2" "139.6" "154.7" "137.7" "147.2" "178.6" "157.0" "153.2" "71.4" "" "" "" "" "" "" "" "" "" "" "87.0" "80.7" "77.3" "72.6" "63.8" "75.4" "83.0" "70.5" "83.1" "71.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3077097618423052072" "False" "High" "IsMasterProtein" "Q15032" "R3H domain-containing protein 1 OS=Homo sapiens OX=9606 GN=R3HDM1 PE=1 SV=3" "0.000" "False" "6.647" "2" "2" "3" "2" "1099" "120.6" "8.75" "4.62" "2" "" "" "" "Pf01424, Pf12752" "23518" "ENSG00000048991" "R3HDM1" "A8K1V0; B3KXQ9; E9PBB4; E9PG42; G5E9G8; hsa:23518; Q15032; Q8IW32" "" "" "0" "0" "1.062" "1.085" "1.110" "1.134" "1.059" "1.254" "1.290" "1.047" "1.261" "100.9" "107.1" "109.5" "112.0" "114.5" "106.9" "126.6" "130.2" "105.7" "127.2" "" "" "" "" "" "" "" "" "" "" "60.4" "55.7" "60.7" "52.6" "53.1" "54.7" "58.8" "58.4" "57.3" "127.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4915588766185396896" "False" "High" "IsMasterProtein" "Q86U44" "N6-adenosine-methyltransferase catalytic subunit OS=Homo sapiens OX=9606 GN=METTL3 PE=1 SV=2" "0.000" "False" "6.632" "4" "1" "2" "1" "580" "64.4" "6.42" "9.77" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05063" "56339" "ENSG00000165819" "METTL3" "hsa:56339; O14736; Q86U44; Q86V05; Q9HB32" "mRNA processing" "Processing of Capped Intron-Containing Pre-mRNA" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3196363809325094679" "False" "High" "IsMasterProtein" "Q9HCU8" "DNA polymerase delta subunit 4 OS=Homo sapiens OX=9606 GN=POLD4 PE=1 SV=1" "0.000" "False" "6.622" "23" "2" "2" "2" "107" "12.4" "6.77" "5.88" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "" "Pf04081" "57804" "ENSG00000175482" "POLD4" "F5H506; hsa:57804; Q9HCU8" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "25" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3258131120717726760" "False" "High" "IsMasterProtein" "Q96EU6" "Ribosomal RNA processing protein 36 homolog OS=Homo sapiens OX=9606 GN=RRP36 PE=1 SV=1" "0.000" "False" "6.618" "6" "1" "1" "1" "259" "29.8" "10.17" "5.64" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf06102" "88745" "ENSG00000124541" "RRP36" "hsa:88745; Q96EU6; Q9BRF6; Q9P0C8" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.828" "0.893" "1.060" "1.097" "0.936" "1.568" "1.029" "1.140" "0.451" "36.1" "29.9" "32.2" "38.2" "39.6" "33.8" "56.6" "37.1" "41.1" "16.3" "" "" "" "" "" "" "" "" "" "" "21.6" "15.5" "17.9" "17.9" "18.3" "17.3" "26.3" "16.7" "22.3" "16.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5005223025872710581" "False" "High" "IsMasterProtein" "O60524" "Ribosome quality control complex subunit NEMF OS=Homo sapiens OX=9606 GN=NEMF PE=1 SV=4" "0.000" "False" "6.611" "2" "2" "2" "2" "1076" "122.9" "6.35" "3.63" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf05670, Pf05833, Pf11923" "9147" "ENSG00000165525" "NEMF" "A0JLQ3; B3KSK1; B4DDL3; B4DHA9; B4E3F3; hsa:9147; O60524; Q32Q66; Q8WW70; Q9NWG1" "" "" "0" "0" "1.220" "1.208" "1.115" "1.187" "1.301" "1.191" "1.043" "1.144" "4.613" "38.4" "46.8" "46.3" "42.8" "45.5" "49.9" "45.7" "40.0" "43.9" "176.9" "" "" "" "" "" "" "" "" "" "" "23.0" "24.3" "25.7" "20.1" "21.1" "25.5" "21.2" "18.0" "23.8" "176.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6933895130976224833" "False" "High" "IsMasterProtein" "P23511" "Nuclear transcription factor Y subunit alpha OS=Homo sapiens OX=9606 GN=NFYA PE=1 SV=2" "0.000" "False" "6.603" "6" "1" "2" "1" "347" "36.9" "8.94" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02045" "4800" "ENSG00000001167" "NFYA" "hsa:4800; P23511; Q8IXU0" "Sterol regulatory element-binding proteins (SREBP) signaling; Wnt signaling pathway and pluripotency; Sudden infant death syndrome (SIDS) susceptibility pathways" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum stress; ATF6 (ATF6-alpha) activates chaperone genes" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6200383293614890998" "False" "High" "IsMasterProtein" "Q9UK45" "U6 snRNA-associated Sm-like protein LSm7 OS=Homo sapiens OX=9606 GN=LSM7 PE=1 SV=1" "0.000" "False" "6.593" "16" "2" "8" "2" "103" "11.6" "5.27" "20.37" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "51690" "ENSG00000130332" "LSM7" "hsa:51690; Q9UK45" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "3" "0" "0.950" "0.885" "0.953" "1.055" "0.988" "1.088" "0.915" "0.971" "1.136" "409.1" "388.5" "362.2" "390.0" "431.4" "404.4" "445.0" "374.2" "397.3" "464.8" "" "" "" "" "" "" "" "" "" "" "244.8" "201.9" "200.6" "183.1" "200.0" "207.0" "206.9" "168.0" "215.6" "464.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4027474892696141167" "False" "High" "IsMasterProtein" "Q9BZI7" "Regulator of nonsense transcripts 3B OS=Homo sapiens OX=9606 GN=UPF3B PE=1 SV=1" "0.000" "False" "6.580" "4" "2" "3" "2" "483" "57.7" "9.48" "8.09" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf03467" "65109" "ENSG00000125351" "UPF3B" "D3DWI3; D3DWI4; hsa:65109; Q0VAK8; Q9BZI7; Q9H1J0" "" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; RNA Polymerase II Transcription Termination; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing" "6" "0" "0.981" "1.048" "0.948" "0.923" "0.945" "1.088" "0.836" "0.935" "1.318" "180.8" "177.4" "189.5" "171.5" "166.8" "170.9" "196.7" "151.1" "169.1" "238.4" "" "" "" "" "" "" "" "" "" "" "108.2" "92.2" "104.9" "80.5" "77.3" "87.5" "91.4" "67.8" "91.7" "238.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-428002072210945893" "False" "High" "IsMasterProtein" "P52657" "Transcription initiation factor IIA subunit 2 OS=Homo sapiens OX=9606 GN=GTF2A2 PE=1 SV=1" "0.000" "False" "6.573" "15" "2" "4" "2" "109" "12.4" "6.62" "12.67" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02268, Pf02751" "2958" "ENSG00000140307" "GTF2A2" "A8MYQ7; hsa:2958; P52657; Q6FGB5" "Eukaryotic transcription initiation" "Estrogen-dependent gene expression; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "11" "0" "0.982" "1.012" "1.072" "1.184" "1.055" "1.084" "1.027" "0.934" "0.698" "736.5" "723.6" "745.0" "789.6" "871.9" "776.8" "798.3" "756.2" "687.7" "514.1" "" "" "" "" "" "" "" "" "" "" "440.8" "376.0" "412.6" "370.7" "404.1" "397.7" "371.2" "339.5" "373.1" "514.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6299048692266605018" "False" "High" "IsMasterProtein" "Q14161" "ARF GTPase-activating protein GIT2 OS=Homo sapiens OX=9606 GN=GIT2 PE=1 SV=2" "0.000" "False" "6.571" "4" "3" "4" "3" "759" "84.5" "7.23" "3.98" "3" "transport;developmental processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf01412, Pf08518, Pf12205, Pf16559" "9815" "ENSG00000139436" "GIT2" "hsa:9815; Q14161; Q86U59; Q96CI2; Q9BV91; Q9Y5V2" "Integrin-mediated cell adhesion" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle" "9" "0" "1.179" "1.201" "1.088" "1.032" "1.280" "1.013" "1.078" "1.080" "2.298" "213.0" "251.2" "255.8" "231.7" "219.8" "272.6" "215.8" "229.6" "230.0" "489.4" "" "" "" "" "" "" "" "" "" "" "127.5" "130.5" "141.6" "108.8" "101.9" "139.6" "100.3" "103.1" "124.8" "489.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3276719871576654886" "False" "High" "IsMasterProtein" "Q92917" "G-patch domain and KOW motifs-containing protein OS=Homo sapiens OX=9606 GN=GPKOW PE=1 SV=2" "0.000" "False" "6.567" "5" "2" "3" "2" "476" "52.2" "6.15" "3.97" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00467, Pf12656" "27238" "ENSG00000068394; ENSG00000292204" "GPKOW" "hsa:27238; Q59EK5; Q92917; Q9BQA8" "" "mRNA Splicing - Major Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7630345377865006626" "False" "High" "IsMasterProtein" "Q9NVS9" "Pyridoxine-5'-phosphate oxidase OS=Homo sapiens OX=9606 GN=PNPO PE=1 SV=1" "0.000" "False" "6.566" "7" "2" "8" "2" "261" "30.0" "7.06" "21.39" "2" "other metabolic processes" "cytosol" "other molecular function" "Pf01243, Pf10590" "55163" "ENSG00000108439" "PNPO" "B4E0V0; B4E152; B4E1D7; D3DTT9; hsa:55163; Q9NVS9" "Selenium micronutrient network; Vitamin B6-dependent and responsive disorders" "Vitamin B6 activation to pyridoxal phosphate" "3" "0" "1.050" "1.061" "1.106" "1.006" "1.042" "1.158" "1.070" "1.013" "1.383" "364.9" "383.1" "387.2" "403.6" "367.1" "380.1" "422.5" "390.6" "369.7" "504.5" "" "" "" "" "" "" "" "" "" "" "218.4" "199.1" "214.4" "189.5" "170.2" "194.6" "196.5" "175.3" "200.6" "504.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1299453744240154091" "False" "High" "IsMasterProtein" "Q96EB1" "Elongator complex protein 4 OS=Homo sapiens OX=9606 GN=ELP4 PE=1 SV=2" "0.000" "False" "6.565" "5" "2" "4" "2" "424" "46.6" "8.51" "13.35" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf05625" "26610" "ENSG00000109911" "ELP4" "B4E3W0; E7EPZ6; hsa:26610; Q96EB1; Q9H4E8; Q9NX11" "Mesodermal commitment pathway" "HATs acetylate histones" "2" "0" "1.016" "0.949" "0.958" "1.087" "1.163" "1.074" "1.107" "1.144" "0.639" "292.0" "296.8" "277.2" "279.6" "317.3" "339.7" "313.8" "323.3" "334.1" "186.5" "" "" "" "" "" "" "" "" "" "" "174.8" "154.3" "153.5" "131.3" "147.1" "173.9" "145.9" "145.2" "181.2" "186.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8343966935655594345" "False" "High" "IsMasterProtein" "P56385" "ATP synthase subunit e, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5ME PE=1 SV=2" "0.000" "False" "6.559" "14" "1" "2" "1" "69" "7.9" "9.35" "4.95" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05680" "521" "ENSG00000169020" "ATP5ME" "hsa:521; P56385; Q0D2L9" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "Cristae formation; Formation of ATP by chemiosmotic coupling" "4" "0" "0.950" "1.027" "1.092" "1.019" "0.945" "1.021" "1.019" "0.912" "0.995" "195.3" "185.5" "200.6" "213.2" "199.1" "184.6" "199.5" "199.0" "178.1" "194.3" "" "" "" "" "" "" "" "" "" "" "116.9" "96.4" "111.1" "100.1" "92.3" "94.5" "92.8" "89.3" "96.7" "194.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6657686065862137180" "False" "High" "IsMasterProtein" "Q9Y371" "Endophilin-B1 OS=Homo sapiens OX=9606 GN=SH3GLB1 PE=1 SV=1" "0.000" "False" "6.544" "7" "3" "3" "3" "365" "40.8" "6.04" "7.08" "3" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03114, Pf14604" "51100" "ENSG00000097033" "SH3GLB1" "B4E182; hsa:51100; Q5H8U5; Q9H3Z0; Q9NR47; Q9NYA9; Q9Y371" "Nanoparticle triggered autophagic cell death" "" "1" "0" "0.817" "2.162" "1.010" "0.944" "0.851" "0.802" "0.272" "0.876" "6.000" "109.6" "89.6" "237.0" "110.8" "103.5" "93.3" "88.0" "29.8" "96.1" "657.9" "" "" "" "" "" "" "" "" "" "" "65.6" "46.6" "131.3" "52.0" "48.0" "47.8" "40.9" "13.4" "52.1" "657.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6199563702112544119" "False" "High" "IsMasterProtein" "Q86XP3" "ATP-dependent RNA helicase DDX42 OS=Homo sapiens OX=9606 GN=DDX42 PE=1 SV=1" "0.000" "False" "6.528" "2" "2" "2" "2" "938" "102.9" "7.02" "5.50" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "11325" "ENSG00000198231" "DDX42" "A6NML1; A8KA43; hsa:11325; O75619; Q68G51; Q86XP3; Q96BK1; Q96HR7; Q9Y3V8" "" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "2" "0" "1.763" "1.905" "1.960" "1.984" "1.434" "1.977" "0.763" "1.751" "9.686" "16.6" "29.2" "31.6" "32.5" "32.9" "23.8" "32.8" "12.7" "29.0" "160.7" "" "" "" "" "" "" "" "" "" "" "9.9" "15.2" "17.5" "15.3" "15.3" "12.2" "15.2" "5.7" "15.8" "160.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4795865386403905334" "False" "High" "IsMasterProtein" "Q9Y4Z0" "U6 snRNA-associated Sm-like protein LSm4 OS=Homo sapiens OX=9606 GN=LSM4 PE=1 SV=1" "0.000" "False" "6.509" "21" "3" "5" "3" "139" "15.3" "9.99" "14.40" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "25804" "ENSG00000130520" "LSM4" "hsa:25804; Q9Y4Z0" "Ciliary landscape" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "3" "0" "1.030" "0.979" "1.012" "1.158" "1.092" "1.130" "1.255" "1.119" "0.476" "281.3" "289.7" "275.3" "284.8" "325.7" "307.3" "317.8" "353.1" "314.9" "133.8" "" "" "" "" "" "" "" "" "" "" "168.4" "150.5" "152.5" "133.7" "150.9" "157.3" "147.8" "158.5" "170.8" "133.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2667466145755123608" "False" "High" "IsMasterProtein" "O75380" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS6 PE=1 SV=1" "0.000" "False" "6.502" "15" "2" "11" "2" "124" "13.7" "8.28" "32.19" "2" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf10276" "4726" "ENSG00000145494" "NDUFS6" "hsa:4726; O75380" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "0.952" "0.964" "0.919" "1.005" "1.087" "0.917" "1.136" "0.927" "0.475" "1166.2" "1110.8" "1124.3" "1072.3" "1172.3" "1268.1" "1069.3" "1325.0" "1081.0" "554.5" "" "" "" "" "" "" "" "" "" "" "697.9" "577.2" "622.6" "503.4" "543.4" "649.2" "497.2" "594.9" "586.5" "554.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2670793063602377093" "False" "High" "IsMasterProtein" "Q8TBZ6" "tRNA methyltransferase 10 homolog A OS=Homo sapiens OX=9606 GN=TRMT10A PE=1 SV=1" "0.000" "False" "6.498" "7" "2" "2" "2" "339" "39.7" "7.65" "2.87" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf01746" "93587" "ENSG00000145331" "TRMT10A" "B2R8X7; hsa:93587; Q8TBZ6; Q9Y2T9" "" "tRNA modification in the nucleus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4559140579210949167" "False" "High" "IsMasterProtein" "P62917" "Large ribosomal subunit protein uL2 OS=Homo sapiens OX=9606 GN=RPL8 PE=1 SV=2" "0.000" "False" "6.493" "7" "2" "4" "2" "257" "28.0" "11.03" "11.61" "2" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00181, Pf03947" "6132" "ENSG00000161016" "RPL8" "A8K094; D3DWN2; hsa:6132; P25120; P62917; Q567Q7; Q969V7; Q9BWQ9" "Cytoplasmic ribosomal proteins" "Protein hydroxylation; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.837" "0.973" "0.991" "0.952" "0.753" "0.894" "0.945" "0.906" "0.262" "224.6" "188.0" "218.4" "222.5" "213.7" "169.0" "200.8" "212.2" "203.5" "58.8" "" "" "" "" "" "" "" "" "" "" "134.4" "97.7" "120.9" "104.4" "99.1" "86.5" "93.4" "95.3" "110.4" "58.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9060406091306601688" "False" "High" "IsMasterProtein" "Q8N806" "Putative E3 ubiquitin-protein ligase UBR7 OS=Homo sapiens OX=9606 GN=UBR7 PE=1 SV=2" "0.000" "False" "6.486" "4" "2" "3" "2" "425" "48.0" "4.81" "7.13" "2" "protein metabolism;other metabolic processes" "" "other molecular function" "Pf02207" "55148" "ENSG00000012963; ENSG00000278787" "UBR7" "Q86U21; Q86UA9; Q8N806; Q96BY0; Q9NVV6" "" "" "0" "0" "0.905" "1.094" "0.950" "1.133" "0.948" "1.128" "1.030" "1.099" "1.909" "167.7" "151.8" "183.4" "159.3" "190.0" "158.9" "189.2" "172.7" "184.2" "320.1" "" "" "" "" "" "" "" "" "" "" "100.4" "78.9" "101.6" "74.8" "88.0" "81.3" "88.0" "77.6" "100.0" "320.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8361684917289872737" "False" "High" "IsMasterProtein" "Q9BSW2" "EF-hand calcium-binding domain-containing protein 4B OS=Homo sapiens OX=9606 GN=CRACR2A PE=1 SV=2" "0.000" "False" "6.478" "3" "2" "2" "2" "731" "83.1" "5.24" "4.59" "2" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00071, Pf13499" "84766" "ENSG00000130038" "CRACR2A" "B4E1X0; B9EK63; hsa:84766; Q9BSW2" "Vitamin D receptor pathway" "Neutrophil degranulation" "2" "0" "1.203" "1.329" "1.146" "1.227" "1.100" "1.207" "1.248" "1.170" "1.660" "71.7" "86.3" "95.3" "82.2" "88.0" "78.9" "86.6" "89.5" "83.9" "119.1" "" "" "" "" "" "" "" "" "" "" "42.9" "44.8" "52.8" "38.6" "40.8" "40.4" "40.2" "40.2" "45.5" "119.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3331703410720076251" "False" "High" "IsMasterProtein" "Q96BN8" "Ubiquitin thioesterase otulin OS=Homo sapiens OX=9606 GN=OTULIN PE=1 SV=3" "0.000" "False" "6.470" "7" "3" "4" "3" "352" "40.2" "5.47" "6.16" "3" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf16218" "90268" "ENSG00000154124" "OTULIN" "D3DTD3; hsa:90268; Q8NAS0; Q96BN8; Q96IA3" "" "Regulation of TNFR1 signaling; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "2" "0" "1.207" "1.018" "1.035" "1.217" "1.299" "0.942" "0.809" "1.359" "4.783" "51.5" "62.2" "52.5" "53.4" "62.7" "66.9" "48.5" "41.7" "70.0" "246.5" "" "" "" "" "" "" "" "" "" "" "30.8" "32.3" "29.1" "25.1" "29.1" "34.3" "22.6" "18.7" "38.0" "246.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1084161266970488512" "False" "High" "IsMasterProtein" "Q04206" "Transcription factor p65 OS=Homo sapiens OX=9606 GN=RELA PE=1 SV=2" "0.000" "False" "6.470" "8" "3" "3" "3" "551" "60.2" "5.68" "4.53" "3" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "5970" "ENSG00000173039" "RELA" "hsa:5970; Q04206; Q6GTV1; Q6SLK1" "Androgen receptor signaling pathway; Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Selenium metabolism and selenoproteins; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; ApoE and miR-146 in inflammation and atherosclerosis; Chemokine signaling pathway; IL-4 signaling pathway; NO/cGMP/PKG mediated neuroprotection; Fibrin complement receptor 3 signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Nonalcoholic fatty liver disease; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; CAMKK2 pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; Opioid receptor pathways; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; Osteoarthritic chondrocyte hypertrophy; 15q11q13 copy number variation; T-cell receptor signaling pathway; Toll-like receptor signaling pathway" "Senescence-Associated Secretory Phenotype (SASP); FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Dectin-1 mediated noncanonical NF-kB signaling; Transcriptional Regulation by VENTX; Transcriptional regulation of white adipocyte differentiation; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; Regulation of NFE2L2 gene expression; CD209 (DC-SIGN) signaling; Interleukin-1 processing; CLEC7A/inflammasome pathway; Regulated proteolysis of p75NTR; SUMOylation of immune response proteins; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "101" "0" "0.937" "0.770" "1.028" "0.902" "0.555" "1.180" "1.075" "1.139" "3.782" "14.6" "13.7" "11.3" "15.0" "13.2" "8.1" "17.3" "15.7" "16.7" "55.3" "" "" "" "" "" "" "" "" "" "" "8.8" "7.1" "6.2" "7.1" "6.1" "4.2" "8.0" "7.1" "9.0" "55.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7367615421387894087" "False" "High" "IsMasterProtein" "Q9Y5X3" "Sorting nexin-5 OS=Homo sapiens OX=9606 GN=SNX5 PE=1 SV=1" "0.000" "False" "6.465" "7" "3" "4" "3" "404" "46.8" "6.76" "8.37" "3" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00787, Pf09325" "27131" "ENSG00000089006" "SNX5" "B7ZKN3; D3DW26; hsa:27131; Q52LC4; Q7KZN0; Q9BWP0; Q9Y5X3" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9146953398004624321" "False" "High" "IsMasterProtein" "Q00613" "Heat shock factor protein 1 OS=Homo sapiens OX=9606 GN=HSF1 PE=1 SV=1" "0.000" "False" "6.457" "3" "1" "2" "1" "529" "57.2" "5.19" "5.13" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00447, Pf06546" "3297" "ENSG00000185122; ENSG00000284774" "HSF1" "A8K4L0; A8MW26; hsa:3297; Q00613; Q53XT4" "10q11.21q11.23 copy number variation syndrome; HDAC6 interactions in the central nervous system" "Regulation of HSF1-mediated heat shock response; Attenuation phase; Aggrephagy; HSF1 activation" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7201160367223049830" "False" "High" "IsMasterProtein" "Cont_Q3MHN5" "Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1" "0.000" "True" "6.442" "3" "2" "2" "2" "474" "53.3" "5.52" "5.78" "2" "transport" "non-structural extracellular;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00273, Pf09164" "530076" "" "GC" "bta:530076; Q3MHN5" "" "" "0" "0" "1.154" "0.971" "1.167" "0.838" "0.838" "1.382" "1.135" "1.179" "0.648" "260.6" "300.6" "253.0" "304.2" "218.3" "218.3" "360.2" "295.8" "307.2" "168.7" "" "" "" "" "" "" "" "" "" "" "156.0" "156.2" "140.1" "142.8" "101.2" "111.7" "167.5" "132.8" "166.6" "168.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1924362681764607279" "False" "High" "IsMasterProtein" "Q8TBF4" "Zinc finger CCHC-type and RNA-binding motif-containing protein 1 OS=Homo sapiens OX=9606 GN=ZCRB1 PE=1 SV=2" "0.000" "False" "6.426" "12" "2" "2" "2" "217" "24.6" "8.53" "2.60" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00076, Pf00098" "85437" "ENSG00000139168" "ZCRB1" "hsa:85437; Q6PJX0; Q8TBF4; Q96TA6" "" "mRNA Splicing - Minor Pathway; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-580197304848334652" "False" "High" "IsMasterProtein" "Q13496" "Myotubularin OS=Homo sapiens OX=9606 GN=MTM1 PE=1 SV=2" "0.000" "False" "6.415" "3" "2" "3" "2" "603" "69.9" "8.18" "7.31" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02893, Pf06602" "4534" "ENSG00000171100" "MTM1" "A6NDB1; B7Z491; F2Z330; hsa:4534; Q13496; Q8NEL1" "" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "3" "0" "1.031" "1.043" "1.348" "1.117" "1.048" "1.129" "1.008" "1.419" "0.675" "30.6" "31.5" "31.9" "41.2" "34.1" "32.0" "34.5" "30.8" "43.4" "20.6" "" "" "" "" "" "" "" "" "" "" "18.3" "16.4" "17.6" "19.3" "15.8" "16.4" "16.0" "13.8" "23.5" "20.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7992266646399474025" "False" "High" "IsMasterProtein" "Q9Y605" "MORF4 family-associated protein 1 OS=Homo sapiens OX=9606 GN=MRFAP1 PE=1 SV=1" "0.000" "False" "6.410" "19" "1" "1" "1" "127" "14.6" "4.70" "4.42" "1" "" "nucleus;other cell component" "" "Pf15155" "93621" "ENSG00000179010" "MRFAP1" "B3KVT2; D3DVT3; hsa:93621; Q9Y605" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "Not Found" "High" "High" "High" "High" "High" "1" "" "2703376622299265366" "False" "High" "IsMasterProtein" "Q9UKF6" "Cleavage and polyadenylation specificity factor subunit 3 OS=Homo sapiens OX=9606 GN=CPSF3 PE=1 SV=1" "0.000" "False" "6.407" "4" "2" "3" "2" "684" "77.4" "5.60" "3.82" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07521, Pf10996, Pf11718, Pf16661" "51692" "ENSG00000119203" "CPSF3" "hsa:51692; O14769; Q53RS2; Q96F36; Q9UKF6" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Transport of Mature mRNA Derived from an Intronless Transcript" "6" "0" "1.072" "1.337" "1.090" "1.791" "1.435" "1.103" "0.711" "1.110" "2.389" "25.6" "27.4" "34.2" "27.9" "45.8" "36.7" "28.2" "18.2" "28.4" "61.1" "" "" "" "" "" "" "" "" "" "" "15.3" "14.2" "18.9" "13.1" "21.2" "18.8" "13.1" "8.2" "15.4" "61.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6548869844035824343" "False" "High" "IsMasterProtein" "Q9UKM9" "RNA-binding protein Raly OS=Homo sapiens OX=9606 GN=RALY PE=1 SV=1" "0.000" "False" "6.399" "6" "2" "3" "2" "306" "32.4" "9.17" "4.30" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "22913" "ENSG00000125970" "RALY" "hsa:22913; Q14621; Q2M365; Q5QPL8; Q9BQX6; Q9UJE3; Q9UKM9" "" "" "0" "0" "0.458" "0.357" "1.040" "1.278" "2.941" "1.017" "0.559" "3.809" "4.749" "16.6" "7.6" "5.9" "17.3" "21.3" "48.9" "16.9" "9.3" "63.4" "79.1" "" "" "" "" "" "" "" "" "" "" "10.0" "4.0" "3.3" "8.1" "9.9" "25.1" "7.9" "4.2" "34.4" "79.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2205363031532401399" "False" "High" "IsMasterProtein" "Q16763" "Ubiquitin-conjugating enzyme E2 S OS=Homo sapiens OX=9606 GN=UBE2S PE=1 SV=2" "0.000" "False" "6.396" "15" "2" "5" "2" "222" "23.8" "8.38" "13.45" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "27338" "ENSG00000108106" "UBE2S" "hsa:27338; Q16763; Q9BTC1" "" "Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "1.057" "1.227" "1.133" "1.164" "1.266" "1.079" "1.028" "1.171" "0.918" "281.4" "297.5" "345.3" "319.0" "327.7" "356.2" "303.6" "289.4" "329.6" "258.4" "" "" "" "" "" "" "" "" "" "" "168.4" "154.6" "191.2" "149.7" "151.9" "182.4" "141.2" "129.9" "178.8" "258.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3718082725162177882" "False" "High" "IsMasterProtein" "O95822" "Malonyl-CoA decarboxylase, mitochondrial OS=Homo sapiens OX=9606 GN=MLYCD PE=1 SV=3" "0.000" "False" "6.392" "4" "2" "2" "2" "493" "55.0" "8.95" "3.37" "2" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05292, Pf17408" "23417" "ENSG00000103150" "MLYCD" "hsa:23417; O95822; Q9UNU5; Q9Y3F2" "" "" "0" "0" "0.915" "0.826" "1.127" "0.937" "0.997" "1.028" "1.054" "0.884" "0.670" "69.7" "63.8" "57.6" "78.6" "65.3" "69.5" "71.7" "73.5" "61.6" "46.7" "" "" "" "" "" "" "" "" "" "" "41.7" "33.2" "31.9" "36.9" "30.3" "35.6" "33.3" "33.0" "33.4" "46.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6462118287367883221" "False" "High" "IsMasterProtein" "Q9Y296" "Trafficking protein particle complex subunit 4 OS=Homo sapiens OX=9606 GN=TRAPPC4 PE=1 SV=1" "0.000" "False" "6.387" "11" "3" "5" "3" "219" "24.3" "6.21" "8.49" "3" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04099" "51399" "ENSG00000196655; ENSG00000280495" "TRAPPC4" "A8K3A5; B4DME1; hsa:51399; Q9Y296" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport; Syndecan interactions" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6270565792586481652" "False" "High" "IsMasterProtein" "Q9UHY7" "Enolase-phosphatase E1 OS=Homo sapiens OX=9606 GN=ENOPH1 PE=1 SV=1" "0.000" "False" "6.385" "10" "3" "6" "3" "261" "28.9" "4.78" "13.03" "3" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00702" "58478" "ENSG00000145293" "ENOPH1" "hsa:58478; Q7Z4C5; Q9BVC2; Q9UHY7" "Methionine de novo and salvage pathway" "Methionine salvage pathway" "2" "0" "1.103" "1.024" "1.269" "1.337" "0.852" "1.002" "0.866" "1.334" "3.251" "54.5" "60.1" "55.8" "69.1" "72.8" "46.4" "54.6" "47.2" "72.7" "177.1" "" "" "" "" "" "" "" "" "" "" "32.6" "31.2" "30.9" "32.4" "33.8" "23.8" "25.4" "21.2" "39.4" "177.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6209481463683659801" "False" "High" "IsMasterProtein" "Q71F23" "Centromere protein U OS=Homo sapiens OX=9606 GN=CENPU PE=1 SV=1" "0.000" "False" "6.383" "4" "1" "1" "1" "418" "47.5" "9.13" "5.18" "1" "cell cycle OR cell proliferation;developmental processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf13097" "79682" "ENSG00000151725" "CENPU" "A2RRD9; hsa:79682; Q09GN2; Q32Q71; Q71F23; Q9H5G1" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Deposition of new CENPA-containing nucleosomes at the centromere; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "0.831" "0.812" "0.983" "0.773" "0.899" "1.132" "1.271" "0.690" "0.820" "32.0" "26.6" "26.0" "31.5" "24.8" "28.8" "36.3" "40.7" "22.1" "26.3" "" "" "" "" "" "" "" "" "" "" "19.2" "13.8" "14.4" "14.8" "11.5" "14.8" "16.9" "18.3" "12.0" "26.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6666030451106529783" "False" "High" "IsMasterProtein" "Q9NRY2" "SOSS complex subunit C OS=Homo sapiens OX=9606 GN=INIP PE=1 SV=1" "0.000" "False" "6.382" "21" "2" "3" "2" "104" "11.4" "9.25" "2.80" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf15925" "58493" "ENSG00000148153" "INIP" "hsa:58493; Q5VWJ7; Q96E04; Q9NRY2; Q9P090" "" "" "0" "0" "1.095" "0.808" "1.465" "0.938" "0.699" "1.211" "1.022" "0.762" "0.743" "52.9" "57.9" "42.8" "77.5" "49.6" "37.0" "64.1" "54.0" "40.3" "39.3" "" "" "" "" "" "" "" "" "" "" "31.7" "30.1" "23.7" "36.4" "23.0" "18.9" "29.8" "24.3" "21.9" "39.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2594177095458516104" "False" "High" "IsMasterProtein" "P24386" "Rab proteins geranylgeranyltransferase component A 1 OS=Homo sapiens OX=9606 GN=CHM PE=1 SV=3" "0.000" "False" "6.380" "3" "2" "2" "2" "653" "73.4" "4.75" "5.92" "2" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "1121" "ENSG00000188419" "CHM" "A1L4D2; hsa:1121; O43732; P24386" "" "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation" "3" "0" "0.736" "1.107" "0.917" "0.980" "0.923" "0.892" "0.826" "1.008" "1.074" "77.0" "56.7" "85.2" "70.6" "75.4" "71.1" "68.6" "63.6" "77.6" "82.7" "" "" "" "" "" "" "" "" "" "" "46.1" "29.5" "47.2" "33.1" "35.0" "36.4" "31.9" "28.6" "42.1" "82.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3820767575237366491" "False" "High" "IsMasterProtein" "Q9HAU5" "Regulator of nonsense transcripts 2 OS=Homo sapiens OX=9606 GN=UPF2 PE=1 SV=1" "0.000" "False" "6.358" "2" "2" "2" "2" "1272" "147.7" "5.69" "4.84" "2" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02854, Pf04050" "26019" "ENSG00000151461" "UPF2" "A6NLJ5; D3DRS0; hsa:26019; Q14BM1; Q5W0J4; Q8N8U1; Q9H1J2; Q9HAU5; Q9NWL1; Q9P2D9; Q9Y4M9" "" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "2" "0" "0.614" "0.486" "0.971" "0.635" "0.730" "0.705" "0.364" "0.738" "3.022" "26.4" "16.2" "12.8" "25.6" "16.8" "19.3" "18.6" "9.6" "19.5" "79.8" "" "" "" "" "" "" "" "" "" "" "15.8" "8.4" "7.1" "12.0" "7.8" "9.9" "8.7" "4.3" "10.6" "79.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2463119363191037669" "False" "High" "IsMasterProtein" "Q66LE6" "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform OS=Homo sapiens OX=9606 GN=PPP2R2D PE=1 SV=1" "0.000" "False" "6.347" "6" "3" "3" "1" "453" "52.0" "6.39" "5.46" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "" "55844" "ENSG00000175470" "PPP2R2D" "A8KAK0; hsa:55844; Q5SQJ2; Q66LE6; Q9P1Y7" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "MASTL Facilitates Mitotic Progression" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6149624510723031081" "False" "High" "IsMasterProtein" "P30043" "Flavin reductase (NADPH) OS=Homo sapiens OX=9606 GN=BLVRB PE=1 SV=3" "0.000" "False" "6.346" "12" "2" "3" "2" "206" "22.1" "7.65" "8.92" "2" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf13460" "645" "ENSG00000090013" "BLVRB" "A6NKD8; B2R5C6; hsa:645; P30043; P32078; P53005; Q32LZ2" "Nuclear receptors meta-pathway; NRF2 pathway; IL-10 anti-inflammatory signaling pathway" "Cytoprotection by HMOX1; Heme degradation" "5" "0" "0.918" "0.809" "1.137" "1.117" "1.039" "0.946" "1.099" "0.937" "2.015" "68.2" "62.6" "55.2" "77.5" "76.1" "70.9" "64.5" "74.9" "63.9" "137.4" "" "" "" "" "" "" "" "" "" "" "40.8" "32.5" "30.5" "36.4" "35.3" "36.3" "30.0" "33.6" "34.6" "137.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4657914547001490376" "False" "High" "IsMasterProtein" "P53778" "Mitogen-activated protein kinase 12 OS=Homo sapiens OX=9606 GN=MAPK12 PE=1 SV=3" "0.000" "False" "6.344" "5" "2" "6" "1" "367" "41.9" "6.39" "12.94" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6300" "ENSG00000188130" "MAPK12" "hsa:6300; P53778; Q14260; Q6IC53; Q99588; Q99672" "Integrin-mediated cell adhesion; Parkinson's disease pathway; S1P receptor signal transduction; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Regulatory circuits of the STAT3 signaling pathway; Hepatitis B infection; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Toll-like receptor signaling pathway" "VEGFA-VEGFR2 Pathway; Myogenesis; NOD1/2 Signaling Pathway; p38MAPK events; DSCAM interactions; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Negative regulation of MAPK pathway" "30" "1" "0.979" "0.975" "1.213" "1.185" "1.154" "1.055" "0.943" "1.186" "1.565" "147.9" "144.8" "144.2" "179.4" "175.2" "170.6" "156.0" "139.5" "175.4" "231.4" "" "" "" "" "" "" "" "" "" "" "88.5" "75.3" "79.9" "84.2" "81.2" "87.3" "72.5" "62.6" "95.1" "231.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3327370381573557729" "False" "High" "IsMasterProtein" "Q99611" "Selenide, water dikinase 2 OS=Homo sapiens OX=9606 GN=SEPHS2 PE=1 SV=3" "0.000" "False" "6.341" "11" "3" "3" "2" "448" "47.3" "5.88" "2.86" "3" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00586, Pf02769" "22928" "ENSG00000179918" "SEPHS2" "hsa:22928; Q99611; Q9BUQ2" "Selenium micronutrient network; Selenium metabolism and selenoproteins" "Selenocysteine synthesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "Not Found" "High" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "-7090269578477503572" "False" "High" "IsMasterProtein" "P29353" "SHC-transforming protein 1 OS=Homo sapiens OX=9606 GN=SHC1 PE=1 SV=4" "0.000" "False" "6.335" "4" "2" "4" "2" "583" "62.8" "6.44" "7.86" "2" "cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00640" "6464" "ENSG00000160691" "SHC1" "B5BU19; D3DV78; hsa:6464; O15290; P29353; Q5T180; Q5T183; Q5T184; Q5T185; Q5T186; Q8N4K5; Q96CL1" "IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL6 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; p38 MAPK signaling pathway; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; EGF/EGFR signaling pathway; Fragile X syndrome; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; GDNF signaling; Macrophage-stimulating protein (MSP) signaling network map; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; RET signaling; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; Tie2 Signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; Signaling by CSF3 (G-CSF); XBP1(S) activates chaperone genes; SHC1 events in EGFR signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Integrin signaling; Erythropoietin activates RAS; Signalling to RAS; Signal attenuation; Interleukin-2 signaling; Interleukin-15 signaling" "65" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2282593962912776213" "False" "High" "IsMasterProtein" "Q15853" "Upstream stimulatory factor 2 OS=Homo sapiens OX=9606 GN=USF2 PE=1 SV=1" "0.000" "False" "6.322" "7" "2" "3" "2" "346" "36.9" "5.10" "8.81" "2" "transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "7392" "ENSG00000105698" "USF2" "hsa:7392; O00671; O00709; Q05750; Q07952; Q15851; Q15852; Q15853; Q6FI33; Q6YI47" "Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)" "Estrogen-dependent gene expression" "2" "0" "1.121" "1.021" "0.986" "1.017" "0.945" "1.280" "0.898" "0.956" "0.654" "32.7" "36.7" "33.4" "32.2" "33.3" "30.9" "41.9" "29.4" "31.3" "21.4" "" "" "" "" "" "" "" "" "" "" "19.6" "19.0" "18.5" "15.1" "15.4" "15.8" "19.5" "13.2" "17.0" "21.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8998736333335138172" "False" "High" "IsMasterProtein" "Q08623" "Pseudouridine-5'-phosphatase OS=Homo sapiens OX=9606 GN=PUDP PE=1 SV=3" "0.000" "False" "6.314" "4" "1" "1" "1" "228" "25.2" "5.31" "3.92" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf13419" "8226" "ENSG00000130021" "PUDP" "B2R7X6; B4DV93; B7Z6Q3; E9PAV8; F5GWZ2; hsa:8226; Q08623; Q53F84; Q96EB8" "" "Pyrimidine salvage" "1" "0" "1.163" "0.965" "0.783" "0.969" "0.894" "0.904" "0.969" "0.991" "0.470" "109.8" "127.7" "106.0" "86.0" "106.4" "98.2" "99.3" "106.5" "108.9" "51.6" "" "" "" "" "" "" "" "" "" "" "65.7" "66.4" "58.7" "40.4" "49.3" "50.3" "46.2" "47.8" "59.1" "51.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8005629595719536467" "False" "High" "IsMasterProtein" "Q12840" "Kinesin heavy chain isoform 5A OS=Homo sapiens OX=9606 GN=KIF5A PE=1 SV=2" "0.000" "False" "6.310" "2" "2" "2" "1" "1032" "117.3" "5.90" "5.82" "2" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3798" "ENSG00000155980" "KIF5A" "A6H8M5; hsa:3798; Q12840; Q4LE26" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Insulin processing; RHO GTPases activate KTN1" "7" "0" "1.087" "0.995" "0.977" "0.937" "0.950" "0.940" "0.999" "0.865" "0.913" "436.3" "474.2" "434.3" "426.3" "408.6" "414.6" "410.1" "435.7" "377.4" "398.2" "" "" "" "" "" "" "" "" "" "" "261.1" "246.4" "240.5" "200.2" "189.4" "212.2" "190.7" "195.6" "204.8" "398.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4144550306187805462" "False" "High" "IsMasterProtein" "Q68E01" "Integrator complex subunit 3 OS=Homo sapiens OX=9606 GN=INTS3 PE=1 SV=1" "0.000" "False" "6.299" "3" "1" "1" "1" "1043" "118.0" "5.80" "3.17" "1" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf10189" "65123" "ENSG00000143624; ENSG00000262826" "INTS3" "A8K1W0; B4DQC8; B4E3U9; D3DV57; hsa:65123; Q4G0E5; Q5VUQ5; Q5VUQ6; Q5VUR0; Q5VUR1; Q68DJ1; Q68E01; Q69YR5; Q6AI57; Q6DKG7; Q6MZQ4; Q6MZZ9; Q8NC46; Q8TB23; Q9H6S9" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "Not Found" "Not Found" "High" "High" "High" "High" "High" "High" "1" "" "-3530209516211162637" "False" "High" "IsMasterProtein" "Q5JRA6" "Transport and Golgi organization protein 1 homolog OS=Homo sapiens OX=9606 GN=MIA3 PE=1 SV=1" "0.000" "False" "6.299" "1" "2" "2" "2" "1907" "213.6" "4.84" "4.55" "2" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf07653" "375056" "ENSG00000154305" "MIA3" "A8K2S0; A8MT05; A8MT13; B7Z430; hsa:375056; Q14083; Q3S4X3; Q5JRA5; Q5JRA6; Q5JRB0; Q5JRB1; Q5JRB2; Q6UVY8; Q86Y60; Q8N8M5; Q92580" "Type I collagen synthesis in the context of osteogenesis imperfecta" "Cargo concentration in the ER; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "4" "0" "0.987" "1.665" "1.222" "1.139" "1.878" "1.175" "1.743" "1.555" "0.772" "15.4" "15.2" "25.7" "18.9" "17.6" "29.0" "18.2" "26.9" "24.0" "11.9" "" "" "" "" "" "" "" "" "" "" "9.2" "7.9" "14.2" "8.9" "8.2" "14.9" "8.4" "12.1" "13.0" "11.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4388316332710741736" "False" "High" "IsMasterProtein" "Q96FS4" "Signal-induced proliferation-associated protein 1 OS=Homo sapiens OX=9606 GN=SIPA1 PE=1 SV=1" "0.000" "False" "6.298" "3" "2" "2" "2" "1042" "112.1" "6.60" "3.41" "2" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf00595, Pf02145, Pf21022" "6494" "ENSG00000213445" "SIPA1" "hsa:6494; O14518; O60484; O60618; Q2YD83; Q96FS4" "MAPK cascade" "Rap1 signalling" "2" "0" "1.057" "1.483" "0.918" "1.250" "1.217" "1.319" "0.686" "1.055" "2.356" "25.9" "27.4" "38.5" "23.8" "32.4" "31.6" "34.2" "17.8" "27.4" "61.1" "" "" "" "" "" "" "" "" "" "" "15.5" "14.2" "21.3" "11.2" "15.0" "16.2" "15.9" "8.0" "14.8" "61.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7694948017889393545" "False" "High" "IsMasterProtein" "Q8N490" "Probable hydrolase PNKD OS=Homo sapiens OX=9606 GN=PNKD PE=1 SV=2" "0.000" "False" "6.269" "4" "1" "2" "1" "385" "42.8" "9.09" "5.02" "1" "other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00753, Pf16123" "25953" "ENSG00000127838" "PNKD" "A8K1F2; hsa:25953; Q8N490; Q96A48; Q9BU26; Q9NSX4; Q9ULN6; Q9Y4T1" "Mitochondrial complex IV assembly" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2073188909526316483" "False" "High" "IsMasterProtein" "Q96RJ3" "Tumor necrosis factor receptor superfamily member 13C OS=Homo sapiens OX=9606 GN=TNFRSF13C PE=1 SV=1" "0.000" "False" "6.262" "11" "2" "2" "2" "184" "18.9" "8.21" "3.05" "2" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf09256" "115650" "ENSG00000159958" "TNFRSF13C" "hsa:115650; Q96RJ3" "" "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway" "2" "0" "0.973" "1.053" "1.075" "1.288" "1.044" "1.095" "1.103" "1.069" "0.567" "87.5" "85.1" "92.1" "94.1" "112.7" "91.3" "95.8" "96.5" "93.5" "49.6" "" "" "" "" "" "" "" "" "" "" "52.4" "44.2" "51.0" "44.2" "52.2" "46.8" "44.5" "43.3" "50.7" "49.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5135100836873347765" "False" "High" "IsMasterProtein" "Q5T200" "Zinc finger CCCH domain-containing protein 13 OS=Homo sapiens OX=9606 GN=ZC3H13 PE=1 SV=1" "0.000" "False" "6.250" "1" "3" "3" "3" "1668" "196.5" "9.42" "8.28" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00642" "23091" "ENSG00000123200" "ZC3H13" "A2A323; hsa:23091; O94936; Q5T1Z9; Q5T200; Q7Z7J3; Q8NDT6; Q9H0L6" "" "" "0" "0" "1.016" "1.109" "1.161" "0.998" "0.918" "1.098" "1.044" "0.953" "0.619" "114.4" "116.2" "126.9" "132.8" "114.1" "105.0" "125.6" "119.4" "109.0" "70.8" "" "" "" "" "" "" "" "" "" "" "68.4" "60.4" "70.2" "62.3" "52.9" "53.8" "58.4" "53.6" "59.1" "70.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5704352961259904218" "False" "High" "IsMasterProtein" "Q14155" "Rho guanine nucleotide exchange factor 7 OS=Homo sapiens OX=9606 GN=ARHGEF7 PE=1 SV=2" "0.000" "False" "6.246" "3" "2" "2" "2" "803" "90.0" "7.09" "4.03" "2" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00169, Pf00307, Pf00621, Pf07653, Pf16614, Pf16615" "8874" "ENSG00000102606" "ARHGEF7" "B1ALK6; B1ALK8; hsa:8874; Q14155; Q3LIA4; Q5W9H0; Q6P9G3; Q6PII2; Q86W63; Q8N3M1" "Integrin-mediated cell adhesion; CAMKK2 pathway; Regulation of actin cytoskeleton" "RHOV GTPase cycle; RHOU GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; Ephrin signaling; RHOA GTPase cycle; CDC42 GTPase cycle; G alpha (12/13) signalling events; RHOQ GTPase cycle; RHOJ GTPase cycle; EGFR downregulation" "14" "0" "1.211" "1.333" "1.438" "1.427" "1.164" "1.333" "1.312" "1.311" "4.363" "34.3" "41.5" "45.7" "49.3" "48.9" "39.9" "45.7" "45.0" "44.9" "149.5" "" "" "" "" "" "" "" "" "" "" "20.5" "21.6" "25.3" "23.1" "22.7" "20.4" "21.2" "20.2" "24.4" "149.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1199984255511246690" "False" "High" "IsMasterProtein" "P85037" "Forkhead box protein K1 OS=Homo sapiens OX=9606 GN=FOXK1 PE=1 SV=1" "0.000" "False" "6.245" "2" "1" "1" "1" "733" "75.4" "9.32" "4.00" "1" "other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf00498" "221937" "ENSG00000164916" "FOXK1" "hsa:221937; P85037" "" "UCH proteinases" "1" "0" "0.912" "0.862" "0.871" "0.640" "0.744" "1.072" "0.859" "0.596" "3.769" "45.5" "41.5" "39.2" "39.6" "29.1" "33.8" "48.8" "39.1" "27.1" "171.5" "" "" "" "" "" "" "" "" "" "" "27.2" "21.6" "21.7" "18.6" "13.5" "17.3" "22.7" "17.6" "14.7" "171.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2244987817245821138" "False" "High" "IsMasterProtein" "Q14004" "Cyclin-dependent kinase 13 OS=Homo sapiens OX=9606 GN=CDK13 PE=1 SV=2" "0.000" "False" "6.219" "1" "2" "4" "1" "1512" "164.8" "9.69" "11.38" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8621" "ENSG00000065883" "CDK13" "hsa:8621; Q14004; Q53G78; Q6DKQ9; Q75MH4; Q75MH5; Q96JN4; Q9H4A0; Q9H4A1; Q9UDR4" "" "TP53 Regulates Transcription of DNA Repair Genes; Neutrophil degranulation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-94552620576090045" "False" "High" "IsMasterProtein" "Q8IYM9" "E3 ubiquitin-protein ligase TRIM22 OS=Homo sapiens OX=9606 GN=TRIM22 PE=1 SV=1" "0.000" "False" "6.209" "4" "2" "3" "2" "498" "56.9" "7.72" "7.82" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13445" "10346" "ENSG00000132274" "TRIM22" "hsa:10346; Q05CQ0; Q15521; Q8IYM9" "" "Interferon gamma signaling" "1" "0" "1.318" "0.873" "1.081" "1.248" "1.188" "1.214" "0.475" "1.231" "4.221" "23.4" "30.8" "20.4" "25.2" "29.2" "27.8" "28.4" "11.1" "28.7" "98.6" "" "" "" "" "" "" "" "" "" "" "14.0" "16.0" "11.3" "11.9" "13.5" "14.2" "13.2" "5.0" "15.6" "98.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3241468308071992901" "False" "High" "IsMasterProtein" "Q8NI08" "Nuclear receptor coactivator 7 OS=Homo sapiens OX=9606 GN=NCOA7 PE=1 SV=2" "0.000" "False" "6.207" "2" "2" "2" "2" "942" "106.1" "5.59" "4.72" "2" "stress response;other biological processes" "nucleus" "other molecular function" "Pf01476, Pf07534" "135112" "ENSG00000111912" "NCOA7" "B2RNS2; B7Z2C4; B9EH71; G8JL91; hsa:135112; Q3LID6; Q4G0V1; Q5TF95; Q6IPQ4; Q6NE83; Q86T89; Q8N1W4; Q8NI08" "Aryl hydrocarbon receptor pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-720179637671099041" "False" "High" "IsMasterProtein" "Q06546" "GA-binding protein alpha chain OS=Homo sapiens OX=9606 GN=GABPA PE=1 SV=1" "0.000" "False" "6.200" "5" "2" "2" "2" "454" "51.3" "4.97" "6.65" "2" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198, Pf11620" "2551" "ENSG00000154727" "GABPA" "hsa:2551; Q06546; Q12939" "Energy metabolism; Allograft rejection; Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression; Pleural mesothelioma" "Transcriptional activation of mitochondrial biogenesis" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1870443060398404245" "False" "High" "IsMasterProtein" "Q9H0N5" "Pterin-4-alpha-carbinolamine dehydratase 2 OS=Homo sapiens OX=9606 GN=PCBD2 PE=1 SV=4" "0.000" "False" "6.198" "13" "2" "3" "1" "130" "14.4" "9.11" "9.87" "2" "other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01329" "84105" "ENSG00000132570" "PCBD2" "hsa:84105; Q8TD40; Q9H0N5" "" "" "0" "1" "1.006" "0.950" "1.022" "0.929" "0.959" "1.042" "0.934" "1.002" "0.455" "319.9" "321.9" "303.9" "326.8" "297.1" "306.7" "333.5" "298.7" "320.5" "145.5" "" "" "" "" "" "" "" "" "" "" "191.4" "167.3" "168.3" "153.4" "137.7" "157.0" "155.1" "134.1" "173.9" "145.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5077624206486076316" "False" "High" "IsMasterProtein" "Q8TC07" "TBC1 domain family member 15 OS=Homo sapiens OX=9606 GN=TBC1D15 PE=1 SV=2" "0.000" "False" "6.195" "2" "1" "2" "1" "691" "79.4" "5.67" "4.92" "1" "other biological processes" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00566, Pf12068" "64786" "ENSG00000121749" "TBC1D15" "B4DMT9; B9A6L6; hsa:64786; J3KNI9; Q8TC07; Q9HA83" "" "TBC/RABGAPs" "1" "0" "0.848" "1.043" "0.956" "0.978" "1.011" "1.155" "0.960" "1.176" "1.660" "20.6" "17.5" "21.5" "19.7" "20.2" "20.8" "23.8" "19.8" "24.3" "34.2" "" "" "" "" "" "" "" "" "" "" "12.3" "9.1" "11.9" "9.3" "9.3" "10.7" "11.1" "8.9" "13.2" "34.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4427751732173954290" "False" "High" "IsMasterProtein" "Q99700" "Ataxin-2 OS=Homo sapiens OX=9606 GN=ATXN2 PE=1 SV=2" "0.000" "False" "6.193" "1" "2" "2" "1" "1313" "140.2" "9.57" "6.80" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity" "Pf06741, Pf07145, Pf14438" "6311" "ENSG00000204842" "ATXN2" "A6NLD4; hsa:6311; Q24JQ7; Q6ZQZ7; Q99493; Q99700" "Parkinson's disease pathway; EGF/EGFR signaling pathway" "" "2" "0" "0.982" "1.008" "1.169" "1.142" "1.114" "0.967" "1.037" "1.089" "1.249" "148.4" "145.7" "149.5" "173.4" "169.5" "165.3" "143.4" "153.9" "161.6" "185.4" "" "" "" "" "" "" "" "" "" "" "88.8" "75.7" "82.8" "81.4" "78.6" "84.6" "66.7" "69.1" "87.7" "185.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-366099160936262297" "False" "High" "IsMasterProtein" "Q9NQG5" "Regulation of nuclear pre-mRNA domain-containing protein 1B OS=Homo sapiens OX=9606 GN=RPRD1B PE=1 SV=1" "0.000" "False" "6.191" "9" "3" "3" "3" "326" "36.9" "5.97" "4.83" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04818, Pf16566" "58490" "ENSG00000101413" "RPRD1B" "hsa:58490; Q1WDE7; Q6PKF4; Q9NQG5" "Modulators of TCR signaling and T cell activation" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.401" "1.074" "0.999" "1.258" "1.454" "1.132" "0.568" "1.016" "2.033" "14.3" "20.0" "15.4" "14.3" "18.0" "20.8" "16.2" "8.1" "14.5" "29.1" "" "" "" "" "" "" "" "" "" "" "8.6" "10.4" "8.5" "6.7" "8.3" "10.6" "7.5" "3.6" "7.9" "29.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6429762109324514714" "False" "High" "IsMasterProtein" "O75607" "Nucleoplasmin-3 OS=Homo sapiens OX=9606 GN=NPM3 PE=1 SV=3" "0.000" "False" "6.190" "6" "1" "1" "1" "178" "19.3" "4.63" "3.91" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03066" "10360" "ENSG00000107833" "NPM3" "hsa:10360; O75607; Q9UNY6" "" "" "0" "0" "1.018" "1.089" "0.758" "0.871" "0.942" "0.947" "0.605" "0.802" "2.370" "99.3" "101.1" "108.1" "75.3" "86.5" "93.5" "94.0" "60.1" "79.6" "235.4" "" "" "" "" "" "" "" "" "" "" "59.4" "52.5" "59.9" "35.4" "40.1" "47.9" "43.7" "27.0" "43.2" "235.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7691749111498675631" "False" "High" "IsMasterProtein" "O14531" "Dihydropyrimidinase-related protein 4 OS=Homo sapiens OX=9606 GN=DPYSL4 PE=1 SV=2" "0.000" "False" "6.188" "3" "1" "4" "1" "572" "61.8" "7.09" "11.69" "1" "developmental processes" "cytosol" "cytoskeletal activity;other molecular function" "Pf01979" "10570" "ENSG00000151640" "DPYSL4" "B2RMQ1; D3DRG5; hsa:10570; O00240; O14531; Q5T0Q7" "" "CRMPs in Sema3A signaling" "1" "0" "1.035" "1.191" "0.996" "1.081" "1.026" "1.120" "1.109" "1.122" "1.092" "151.5" "156.9" "180.4" "150.8" "163.8" "155.4" "169.7" "168.0" "169.9" "165.5" "" "" "" "" "" "" "" "" "" "" "90.7" "81.5" "99.9" "70.8" "75.9" "79.5" "78.9" "75.4" "92.2" "165.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5779447610884953183" "False" "High" "IsMasterProtein" "Q9NPD8" "Ubiquitin-conjugating enzyme E2 T OS=Homo sapiens OX=9606 GN=UBE2T PE=1 SV=1" "0.000" "False" "6.174" "14" "3" "4" "3" "197" "22.5" "7.99" "9.37" "3" "protein metabolism;DNA metabolism;other metabolic processes;stress response" "nucleus" "other molecular function" "Pf00179" "29089" "ENSG00000077152" "UBE2T" "hsa:29089; Q2TU36; Q9NPD8" "Gastric cancer network 2" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Fanconi Anemia Pathway" "3" "0" "1.024" "1.048" "1.064" "1.066" "1.026" "0.891" "1.245" "1.164" "0.898" "177.9" "182.2" "186.4" "189.4" "189.7" "182.6" "158.5" "221.5" "207.0" "159.7" "" "" "" "" "" "" "" "" "" "" "106.5" "94.7" "103.2" "88.9" "87.9" "93.5" "73.7" "99.5" "112.3" "159.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3464311242002607672" "False" "High" "IsMasterProtein" "P86790" "Vacuolar fusion protein CCZ1 homolog B OS=Homo sapiens OX=9606 GN=CCZ1B PE=1 SV=1" "0.000" "False" "6.166" "5" "2" "2" "2" "482" "55.8" "6.48" "6.23" "2" "transport" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf19031, Pf19032, Pf19033" "221960; 51622" "ENSG00000146574" "CCZ1B" "A2RU45; hsa:221960; hsa:51622; O95766; P86790; Q9UG65; Q9Y359" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5797798922783167285" "False" "High" "IsMasterProtein" "Q2TAY7" "WD40 repeat-containing protein SMU1 OS=Homo sapiens OX=9606 GN=SMU1 PE=1 SV=2" "0.000" "False" "6.165" "4" "3" "4" "3" "513" "57.5" "7.18" "9.44" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf17814" "55234" "ENSG00000122692" "SMU1" "B4E3L0; hsa:55234; Q2TAY7; Q9BU59; Q9HA96; Q9NVD1" "" "mRNA Splicing - Major Pathway" "1" "0" "0.991" "0.967" "1.241" "1.035" "1.201" "1.223" "1.088" "1.045" "1.960" "42.7" "42.3" "41.2" "52.9" "44.2" "51.2" "52.2" "46.4" "44.6" "83.6" "" "" "" "" "" "" "" "" "" "" "25.5" "22.0" "22.8" "24.8" "20.5" "26.2" "24.3" "20.8" "24.2" "83.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-502285001895834817" "False" "High" "IsMasterProtein" "Q99638" "Cell cycle checkpoint control protein RAD9A OS=Homo sapiens OX=9606 GN=RAD9A PE=1 SV=1" "0.000" "False" "6.161" "7" "2" "2" "2" "391" "42.5" "5.66" "3.10" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04139" "5883" "ENSG00000172613" "RAD9A" "B2RCZ8; hsa:5883; Q6FI29; Q96C41; Q99638" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; ATM signaling pathway; ATR signaling; DNA IR-double strand breaks and cellular response via ATM; NF1 copy number variation syndrome ; DNA damage response" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Activation of ATR in response to replication stress; Regulation of TP53 Activity through Phosphorylation; Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1710957495581241362" "False" "High" "IsMasterProtein" "Q15276" "Rab GTPase-binding effector protein 1 OS=Homo sapiens OX=9606 GN=RABEP1 PE=1 SV=2" "0.000" "False" "6.157" "2" "2" "2" "2" "862" "99.2" "5.01" "5.49" "2" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf03528, Pf09311" "9135" "ENSG00000029725" "RABEP1" "B2RAG7; hsa:9135; O95369; Q15276; Q8IVX3" "GDNF signaling" "TBC/RABGAPs" "2" "0" "1.320" "1.330" "1.320" "1.395" "1.120" "1.093" "1.133" "1.367" "1.583" "82.4" "108.7" "109.6" "108.7" "115.0" "92.3" "90.0" "93.3" "112.6" "130.4" "" "" "" "" "" "" "" "" "" "" "49.3" "56.5" "60.7" "51.0" "53.3" "47.3" "41.9" "41.9" "61.1" "130.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "652466818170242457" "False" "High" "IsMasterProtein" "Q9H993" "Damage-control phosphatase ARMT1 OS=Homo sapiens OX=9606 GN=ARMT1 PE=1 SV=1" "0.000" "False" "6.128" "4" "2" "2" "2" "441" "51.1" "5.76" "4.45" "2" "other metabolic processes;stress response" "" "other molecular function" "Pf01937" "79624" "ENSG00000146476" "ARMT1" "hsa:79624; Q96FC6; Q9H993; Q9UFY5" "" "" "0" "0" "1.412" "1.217" "1.154" "1.355" "1.121" "1.545" "0.010" "1.391" "14.415" "6.1" "8.7" "7.5" "7.1" "8.3" "6.9" "9.5" "0.0" "8.5" "88.5" "" "" "" "" "" "" "" "" "" "" "3.7" "4.5" "4.1" "3.3" "3.9" "3.5" "4.4" "0.0" "4.6" "88.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "107248944887719922" "False" "High" "IsMasterProtein" "Q6VN20" "Ran-binding protein 10 OS=Homo sapiens OX=9606 GN=RANBP10 PE=1 SV=1" "0.000" "False" "6.117" "4" "2" "2" "2" "620" "67.2" "6.77" "2.57" "2" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf00622, Pf08513, Pf10607" "57610" "ENSG00000141084" "RANBP10" "A4FTY2; B4DID0; B4DQH9; E7EW27; hsa:57610; Q6VN20; Q9P264" "Ciliary landscape" "MET activates RAS signaling" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9144815558027084880" "False" "High" "IsMasterProtein" "Q96FV9" "THO complex subunit 1 OS=Homo sapiens OX=9606 GN=THOC1 PE=1 SV=1" "0.000" "False" "6.113" "4" "2" "2" "2" "657" "75.6" "4.98" "4.29" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00531, Pf11957" "9984" "ENSG00000079134" "THOC1" "B2RBP6; hsa:9984; Q15219; Q64I72; Q64I73; Q96FV9" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819630258189506626" "False" "High" "IsMasterProtein" "P02792" "Ferritin light chain OS=Homo sapiens OX=9606 GN=FTL PE=1 SV=2" "0.000" "False" "6.110" "15" "3" "8" "3" "175" "20.0" "5.78" "19.43" "3" "transport;other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00210" "2512" "ENSG00000087086" "FTL" "B2R4B9; hsa:2512; P02792; Q6IBT7; Q7Z2W1; Q86WI9; Q8WU07; Q96AU9; Q96CU0; Q9BTZ8" "Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Iron metabolism disorders" "Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Iron uptake and transport; Scavenging by Class A Receptors" "9" "0" "0.880" "0.980" "0.996" "0.968" "0.995" "1.105" "0.896" "0.876" "0.601" "190.7" "167.8" "186.8" "189.8" "184.6" "189.7" "210.7" "170.9" "167.0" "114.6" "" "" "" "" "" "" "" "" "" "" "114.1" "87.2" "103.4" "89.1" "85.6" "97.1" "98.0" "76.7" "90.6" "114.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-519635040323081051" "False" "High" "IsMasterProtein" "P60953" "Cell division control protein 42 homolog OS=Homo sapiens OX=9606 GN=CDC42 PE=1 SV=2" "0.000" "False" "6.107" "16" "3" "3" "2" "191" "21.2" "6.55" "5.27" "3" "cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00071" "998" "ENSG00000070831" "CDC42" "hsa:998; P21181; P25763; P60953; Q7L8R5; Q9UDI2" "Androgen receptor signaling pathway; Target of rapamycin signaling; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Metastatic brain tumor; Pathogenic Escherichia coli infection; RalA downstream regulated genes; B cell receptor signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Focal adhesion; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Oxidative damage response; p38 MAPK signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; Genetic causes of porto-sinusoidal vascular disease; 13q12.12 copy number variation; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; MAPK6/MAPK4 signaling; RHO GTPases Activate WASPs and WAVEs; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; RHOU GTPase cycle; EPHB-mediated forward signaling; DCC mediated attractive signaling; GPVI-mediated activation cascade; VEGFA-VEGFR2 Pathway; Myogenesis; Factors involved in megakaryocyte development and platelet production; G beta:gamma signalling through CDC42; EGFR downregulation; RHO GTPases activate PAKs; Inactivation of CDC42 and RAC1; CD28 dependent Vav1 pathway; RHO GTPases activate KTN1" "63" "0" "0.965" "0.987" "0.858" "1.085" "1.003" "1.022" "0.944" "1.075" "0.955" "288.4" "278.4" "284.6" "247.3" "313.0" "289.3" "294.9" "272.1" "310.0" "275.4" "" "" "" "" "" "" "" "" "" "" "172.6" "144.7" "157.6" "116.1" "145.1" "148.1" "137.1" "122.2" "168.2" "275.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4399142244827454415" "False" "High" "IsMasterProtein" "Q8NFD5" "AT-rich interactive domain-containing protein 1B OS=Homo sapiens OX=9606 GN=ARID1B PE=1 SV=3" "0.000" "False" "6.107" "2" "3" "3" "3" "2319" "243.8" "6.90" "1.71" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01388, Pf12031" "57492" "ENSG00000049618" "ARID1B" "hsa:57492; Q5JRD1; Q5VYC4; Q8IZY8; Q8NFD5; Q8TEV0; Q8TF02; Q99491; Q9ULI5" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-367492356169293166" "False" "High" "IsMasterProtein" "Q12965" "Unconventional myosin-Ie OS=Homo sapiens OX=9606 GN=MYO1E PE=1 SV=2" "0.000" "False" "6.099" "2" "2" "3" "2" "1108" "127.0" "8.92" "7.76" "2" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf00063, Pf06017" "4643" "ENSG00000157483" "MYO1E" "hsa:4643; Q12965; Q14778" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome" "" "2" "0" "0.825" "0.891" "1.270" "1.447" "1.153" "1.238" "0.379" "1.008" "6.620" "36.8" "30.3" "32.8" "46.7" "53.2" "42.4" "45.5" "13.9" "37.1" "243.5" "" "" "" "" "" "" "" "" "" "" "22.0" "15.8" "18.2" "21.9" "24.7" "21.7" "21.2" "6.3" "20.1" "243.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2160621710341352314" "False" "High" "IsMasterProtein" "O14964" "Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Homo sapiens OX=9606 GN=HGS PE=1 SV=1" "0.000" "False" "6.085" "3" "2" "2" "2" "777" "86.1" "6.16" "3.12" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf01363, Pf12210" "9146" "ENSG00000185359" "HGS" "hsa:9146; O14964; Q9NR36" "TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway" "Ub-specific processing proteases; Endosomal Sorting Complex Required For Transport (ESCRT); Lysosome Vesicle Biogenesis; RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Inhibition of membrane repair; Prevention of phagosomal-lysosomal fusion; RHOBTB3 ATPase cycle" "16" "0" "1.144" "1.155" "1.179" "1.206" "1.106" "1.101" "0.848" "1.016" "3.010" "53.2" "60.8" "61.5" "62.7" "64.2" "58.9" "58.6" "45.1" "54.1" "160.1" "" "" "" "" "" "" "" "" "" "" "31.8" "31.6" "34.0" "29.4" "29.7" "30.1" "27.2" "20.3" "29.3" "160.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1054037842820128470" "False" "High" "IsMasterProtein" "Q9BXK1" "Krueppel-like factor 16 OS=Homo sapiens OX=9606 GN=KLF16 PE=1 SV=1" "0.000" "False" "6.080" "10" "1" "1" "1" "252" "25.4" "9.88" "4.97" "1" "signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "83855" "ENSG00000129911" "KLF16" "hsa:83855; Q9BXK1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "Not Found" "Not Found" "Not Found" "High" "High" "High" "1" "" "-8764284085983728716" "False" "High" "IsMasterProtein" "P18583" "Protein SON OS=Homo sapiens OX=9606 GN=SON PE=1 SV=4" "0.000" "False" "6.080" "1" "2" "2" "2" "2426" "263.7" "5.64" "2.09" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf01585, Pf14709, Pf17069" "6651" "ENSG00000159140" "SON" "D3DSF5; D3DSF6; E7ETE8; E7EU67; E7EVW3; E9PFQ2; hsa:6651; O14487; O95981; P18583; Q14120; Q6PKE0; Q9H7B1; Q9P070; Q9P072; Q9UKP9; Q9UPY0" "" "" "0" "0" "0.896" "1.423" "1.178" "1.534" "1.078" "1.489" "1.043" "1.629" "2.321" "21.3" "19.1" "30.3" "25.1" "32.7" "23.0" "31.7" "22.2" "34.7" "49.5" "" "" "" "" "" "" "" "" "" "" "12.8" "9.9" "16.8" "11.8" "15.1" "11.8" "14.7" "10.0" "18.8" "49.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8566707279340017586" "False" "High" "IsMasterProtein" "Q9Y6M7" "Sodium bicarbonate cotransporter 3 OS=Homo sapiens OX=9606 GN=SLC4A7 PE=1 SV=2" "0.000" "False" "6.064" "2" "2" "3" "2" "1214" "136.0" "6.71" "7.03" "2" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00955, Pf07565" "9497" "ENSG00000033867" "SLC4A7" "A6NIA8; B2CI53; B5M449; B5M451; B5M452; B5M453; B6DY52; B6DY53; C9JST9; D3K174; D3K175; hsa:9497; O60350; Q6AHZ9; Q9HC88; Q9UIB9; Q9Y6M7" "IL-18 signaling pathway" "RHOQ GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; RHOH GTPase cycle; Bicarbonate transporters" "7" "0" "1.515" "1.108" "1.500" "1.215" "1.299" "1.825" "1.049" "1.466" "1.200" "32.8" "49.8" "36.4" "49.3" "39.9" "42.7" "59.9" "34.5" "48.1" "39.4" "" "" "" "" "" "" "" "" "" "" "19.7" "25.9" "20.1" "23.1" "18.5" "21.9" "27.9" "15.5" "26.1" "39.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2998668594604991471" "False" "High" "IsMasterProtein" "O14910" "Protein lin-7 homolog A OS=Homo sapiens OX=9606 GN=LIN7A PE=1 SV=2" "0.000" "False" "6.058" "7" "2" "2" "2" "233" "26.0" "8.72" "5.46" "2" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00595, Pf02828" "8825" "ENSG00000111052" "LIN7A" "A4FTY3; hsa:8825; O14910; Q147W1; Q6LES3; Q7LDS4" "Cell lineage map for neuronal differentiation" "Assembly and cell surface presentation of NMDA receptors; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle" "4" "0" "1.129" "1.035" "1.113" "1.201" "1.256" "1.027" "1.222" "1.344" "1.137" "130.7" "147.6" "135.3" "145.5" "157.0" "164.2" "134.3" "159.7" "175.7" "148.7" "" "" "" "" "" "" "" "" "" "" "78.2" "76.7" "75.0" "68.3" "72.8" "84.0" "62.4" "71.7" "95.3" "148.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "583939558635172856" "False" "High" "IsMasterProtein" "Q9Y4P1" "Cysteine protease ATG4B OS=Homo sapiens OX=9606 GN=ATG4B PE=1 SV=2" "0.000" "False" "6.057" "4" "2" "2" "2" "393" "44.3" "5.07" "4.98" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03416, Pf20166" "23192" "ENSG00000168397" "ATG4B" "B7WNK2; hsa:23192; Q53NU4; Q6ZUV8; Q8WYM9; Q96K07; Q96K96; Q96SZ1; Q9Y2F2; Q9Y4P1" "2q37 copy number variation syndrome" "Macroautophagy" "2" "0" "1.150" "1.141" "1.006" "1.529" "1.769" "2.007" "0.809" "1.472" "13.138" "15.8" "18.2" "18.0" "15.9" "24.2" "28.0" "31.7" "12.8" "23.3" "207.6" "" "" "" "" "" "" "" "" "" "" "9.5" "9.4" "10.0" "7.5" "11.2" "14.3" "14.7" "5.7" "12.6" "207.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2748783261369810529" "False" "High" "IsMasterProtein" "P11182" "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DBT PE=1 SV=4" "0.000" "False" "6.036" "5" "1" "1" "1" "482" "53.5" "8.51" "3.63" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "0.997" "1.185" "0.927" "0.930" "1.186" "0.965" "0.949" "0.898" "0.768" "41.9" "41.8" "49.6" "38.9" "39.0" "49.7" "40.5" "39.8" "37.6" "32.2" "" "" "" "" "" "" "" "" "" "" "25.1" "21.7" "27.5" "18.2" "18.1" "25.4" "18.8" "17.9" "20.4" "32.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5939378456610215612" "False" "High" "IsMasterProtein" "O95819" "Mitogen-activated protein kinase kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP4K4 PE=1 SV=2" "0.000" "False" "6.030" "3" "4" "4" "4" "1239" "142.0" "7.46" "5.96" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00780" "9448" "ENSG00000071054" "MAP4K4" "E7ESS2; hsa:9448; O75172; O95819; Q9NST7" "MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Pleural mesothelioma" "Oxidative Stress Induced Senescence" "7" "0" "0.931" "0.885" "1.064" "1.043" "1.051" "1.155" "0.962" "0.914" "1.661" "182.0" "169.3" "161.0" "193.6" "189.7" "191.2" "210.1" "175.1" "166.2" "302.3" "" "" "" "" "" "" "" "" "" "" "108.9" "88.0" "89.2" "90.9" "88.0" "97.9" "97.7" "78.6" "90.2" "302.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7008442538818735376" "False" "High" "IsMasterProtein" "Q8N4T8" "3-oxoacyl-[acyl-carrier-protein] reductase OS=Homo sapiens OX=9606 GN=CBR4 PE=1 SV=3" "0.000" "False" "6.029" "10" "2" "2" "2" "237" "25.3" "9.33" "5.69" "2" "cell organization and biogenesis;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf13561" "84869" "ENSG00000145439" "CBR4" "hsa:84869; Q8N4T8; Q8WTW8; Q96K93" "" "Fatty acyl-CoA biosynthesis" "1" "0" "1.018" "0.980" "1.031" "1.124" "1.148" "1.056" "0.947" "0.915" "0.778" "157.9" "160.8" "154.8" "162.8" "177.5" "181.3" "166.8" "149.5" "144.5" "122.8" "" "" "" "" "" "" "" "" "" "" "94.5" "83.6" "85.7" "76.4" "82.3" "92.8" "77.6" "67.1" "78.4" "122.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2487901490658103836" "False" "High" "IsMasterProtein" "O75995" "SAM and SH3 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=SASH3 PE=1 SV=2" "0.000" "False" "6.024" "7" "2" "3" "2" "380" "41.6" "5.27" "6.46" "2" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "" "Pf00536, Pf07653, Pf12485" "54440" "ENSG00000122122" "SASH3" "A6NCH1; A8K7K8; hsa:54440; O75995; Q5JZ38" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7698628990297234698" "False" "High" "IsMasterProtein" "Q9Y3D3" "Small ribosomal subunit protein bS16m OS=Homo sapiens OX=9606 GN=MRPS16 PE=1 SV=1" "0.000" "False" "6.023" "15" "2" "2" "2" "137" "15.3" "9.50" "5.49" "2" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "other molecular function" "Pf00886" "51021" "ENSG00000182180" "MRPS16" "B4E032; hsa:51021; Q96Q60; Q9Y3D3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3636619179613661127" "False" "High" "IsMasterProtein" "Cont_A2I7N1" "Serpin A3-5 OS=Bos taurus OX=9913 GN=SERPINA3-5 PE=3 SV=1" "0.000" "True" "6.016" "7" "3" "3" "3" "411" "46.4" "6.96" "5.39" "3" "" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00079" "617667" "" "SERPINA3-5" "A2I7N1" "" "" "0" "0" "1.116" "1.176" "1.045" "0.714" "1.088" "1.034" "1.026" "1.062" "0.737" "60.7" "67.8" "71.4" "63.5" "43.3" "66.1" "62.8" "62.3" "64.5" "44.8" "" "" "" "" "" "" "" "" "" "" "36.3" "35.2" "39.5" "29.8" "20.1" "33.8" "29.2" "28.0" "35.0" "44.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7543040224215837261" "False" "High" "IsMasterProtein" "Q96EY4" "Translation machinery-associated protein 16 OS=Homo sapiens OX=9606 GN=TMA16 PE=1 SV=2" "0.000" "False" "6.009" "7" "2" "2" "2" "203" "23.8" "9.26" "6.30" "2" "other biological processes" "nucleus" "other molecular function" "Pf11176" "55319" "ENSG00000198498" "TMA16" "hsa:55319; Q0P6E4; Q0P6J1; Q96EY4; Q9NUR7" "" "" "0" "0" "0.942" "0.854" "0.921" "1.083" "0.862" "0.981" "0.737" "0.892" "1.649" "102.4" "96.4" "87.4" "94.3" "110.9" "88.2" "100.4" "75.4" "91.3" "168.8" "" "" "" "" "" "" "" "" "" "" "61.3" "50.1" "48.4" "44.3" "51.4" "45.1" "46.7" "33.9" "49.5" "168.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5208446995115017732" "False" "High" "IsMasterProtein" "Q5TFE4" "5'-nucleotidase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NT5DC1 PE=1 SV=1" "0.000" "False" "6.007" "5" "2" "3" "2" "455" "51.8" "6.35" "9.08" "2" "" "" "other molecular function" "Pf05761" "221294" "ENSG00000178425" "NT5DC1" "B2RND9; B3KR35; hsa:221294; Q5TFE4; Q6XYD5" "" "" "0" "0" "0.790" "0.810" "1.016" "0.894" "0.803" "0.995" "0.903" "0.975" "0.660" "55.1" "43.5" "44.6" "56.0" "49.2" "44.2" "54.8" "49.7" "53.7" "36.3" "" "" "" "" "" "" "" "" "" "" "32.9" "22.6" "24.7" "26.3" "22.8" "22.6" "25.5" "22.3" "29.1" "36.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9112301912693417232" "False" "High" "IsMasterProtein" "Q13332" "Receptor-type tyrosine-protein phosphatase S OS=Homo sapiens OX=9606 GN=PTPRS PE=1 SV=3" "0.000" "False" "6.004" "1" "2" "2" "2" "1948" "216.9" "6.46" "4.88" "2" "cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00041, Pf00102, Pf07679, Pf13927" "5802" "ENSG00000105426" "PTPRS" "hsa:5802; O75255; O75870; Q13332; Q15718; Q16341; Q2M3R7" "" "ECM proteoglycans; Synaptic adhesion-like molecules; Receptor-type tyrosine-protein phosphatases; Signaling by NTRK3 (TRKC)" "4" "0" "0.874" "0.969" "1.016" "1.130" "1.044" "1.095" "1.085" "0.998" "1.112" "84.3" "73.7" "81.7" "85.7" "95.3" "88.0" "92.3" "91.5" "84.2" "93.8" "" "" "" "" "" "" "" "" "" "" "50.5" "38.3" "45.2" "40.2" "44.2" "45.0" "42.9" "41.1" "45.7" "93.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2990327377986760395" "False" "High" "IsMasterProtein" "Q8N9Q2" "Protein SREK1IP1 OS=Homo sapiens OX=9606 GN=SREK1IP1 PE=1 SV=1" "0.000" "False" "6.000" "12" "2" "2" "2" "155" "18.2" "9.85" "6.39" "2" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf13917" "285672" "ENSG00000153006" "SREK1IP1" "hsa:285672; Q32NC8; Q8N9Q2" "" "" "0" "0" "0.889" "0.969" "0.942" "1.116" "0.896" "1.063" "1.031" "1.048" "0.758" "141.2" "125.6" "136.7" "132.9" "157.6" "126.5" "150.0" "145.5" "147.9" "107.0" "" "" "" "" "" "" "" "" "" "" "84.5" "65.2" "75.7" "62.4" "73.0" "64.8" "69.7" "65.3" "80.2" "107.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2567249118239018231" "False" "High" "IsMasterProtein" "Q9C0B5" "Palmitoyltransferase ZDHHC5 OS=Homo sapiens OX=9606 GN=ZDHHC5 PE=1 SV=2" "0.000" "False" "6.000" "5" "3" "3" "3" "715" "77.5" "9.01" "4.31" "3" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01529" "25921" "ENSG00000156599" "ZDHHC5" "hsa:25921; Q2TGF0; Q6ZMF0; Q8TAK8; Q9C0B5; Q9H923; Q9UFI7" "" "Maturation of spike protein" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-675276312923681114" "False" "High" "IsMasterProtein" "Q96GY0" "Zinc finger C2HC domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ZC2HC1A PE=1 SV=2" "0.000" "False" "5.996" "5" "2" "2" "2" "325" "35.1" "9.82" "5.77" "2" "" "" "other molecular function" "Pf13913" "51101" "ENSG00000104427" "ZC2HC1A" "hsa:51101; Q96GY0; Q9Y372" "" "" "0" "0" "0.926" "0.982" "1.025" "0.973" "1.032" "0.965" "0.938" "0.872" "0.824" "177.6" "164.3" "174.3" "182.0" "172.8" "183.3" "171.4" "166.5" "154.8" "146.3" "" "" "" "" "" "" "" "" "" "" "106.3" "85.4" "96.5" "85.4" "80.1" "93.8" "79.7" "74.8" "84.0" "146.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3107589471447250441" "False" "High" "IsMasterProtein" "Q9NV06" "DDB1- and CUL4-associated factor 13 OS=Homo sapiens OX=9606 GN=DCAF13 PE=1 SV=2" "0.000" "False" "5.977" "6" "3" "3" "3" "445" "51.4" "9.19" "5.23" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400, Pf04158, Pf08662" "25879" "ENSG00000164934" "DCAF13" "hsa:25879; Q3MII9; Q8NCH8; Q8TC51; Q96JY7; Q9NV06; Q9NZX3" "" "Major pathway of rRNA processing in the nucleolus and cytosol; Neddylation; rRNA modification in the nucleus and cytosol" "3" "0" "0.776" "0.933" "0.907" "0.800" "0.889" "0.836" "0.963" "0.810" "0.408" "126.7" "98.4" "118.2" "115.0" "101.4" "112.7" "105.9" "122.0" "102.6" "51.7" "" "" "" "" "" "" "" "" "" "" "75.8" "51.1" "65.5" "54.0" "47.0" "57.7" "49.3" "54.8" "55.7" "51.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4240907950946080993" "False" "High" "IsMasterProtein" "Q9BV44" "tRNA (guanine(6)-N2)-methyltransferase THUMP3 OS=Homo sapiens OX=9606 GN=THUMPD3 PE=1 SV=1" "0.000" "False" "5.974" "4" "2" "5" "2" "507" "57.0" "6.37" "12.42" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01170, Pf02926" "25917" "ENSG00000134077" "THUMPD3" "hsa:25917; Q9BV44; Q9H8V6; Q9NVC1; Q9UFS3" "" "" "0" "0" "1.162" "1.103" "1.095" "1.139" "1.226" "1.230" "1.300" "1.160" "0.925" "216.6" "251.8" "238.9" "237.1" "246.6" "265.5" "266.3" "281.6" "251.3" "200.4" "" "" "" "" "" "" "" "" "" "" "129.6" "130.8" "132.3" "111.3" "114.3" "135.9" "123.8" "126.4" "136.3" "200.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4992003344612717305" "False" "High" "IsMasterProtein" "P30260" "Cell division cycle protein 27 homolog OS=Homo sapiens OX=9606 GN=CDC27 PE=1 SV=2" "0.000" "False" "5.972" "4" "3" "3" "3" "824" "91.8" "7.02" "2.40" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00515, Pf12895" "996" "ENSG00000004897" "CDC27" "G3V1C4; hsa:996; P30260; Q16349; Q96F35" "Cell cycle; 2q21.1 copy number variation syndrome" "Assembly of the pre-replicative complex; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "20" "0" "1.135" "1.038" "1.166" "1.092" "0.972" "0.989" "0.915" "1.100" "1.546" "94.0" "106.7" "97.6" "109.6" "102.7" "91.4" "93.0" "86.1" "103.4" "145.4" "" "" "" "" "" "" "" "" "" "" "56.3" "55.4" "54.0" "51.5" "47.6" "46.8" "43.2" "38.6" "56.1" "145.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4871299150167349072" "False" "High" "IsMasterProtein" "Q8TF68" "Zinc finger protein 384 OS=Homo sapiens OX=9606 GN=ZNF384 PE=1 SV=2" "0.000" "False" "5.952" "4" "2" "2" "2" "577" "63.2" "8.95" "5.99" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13912" "171017" "ENSG00000126746" "ZNF384" "hsa:171017; O15407; Q7Z722; Q8N938; Q8TF68" "" "" "0" "0" "0.835" "0.855" "1.012" "1.121" "0.946" "0.915" "0.844" "0.864" "0.929" "121.2" "101.2" "103.6" "122.7" "136.0" "114.7" "111.0" "102.3" "104.8" "112.6" "" "" "" "" "" "" "" "" "" "" "72.6" "52.6" "57.4" "57.6" "63.0" "58.7" "51.6" "45.9" "56.9" "112.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1533138465656150959" "False" "High" "IsMasterProtein" "Q5VWQ0" "Lysine-specific demethylase 9 OS=Homo sapiens OX=9606 GN=RSBN1 PE=1 SV=2" "0.000" "False" "5.951" "3" "2" "2" "2" "802" "90.0" "8.60" "5.30" "2" "cell organization and biogenesis" "nucleus" "other molecular function" "" "54665" "ENSG00000081019" "RSBN1" "A8K937; hsa:54665; Q5VWQ0; Q6AI21; Q8TC33; Q9HA80; Q9NUP6" "" "" "0" "0" "0.882" "1.344" "1.202" "0.842" "0.988" "1.115" "0.915" "1.099" "1.440" "17.0" "15.0" "22.9" "20.5" "14.4" "16.8" "19.0" "15.6" "18.7" "24.6" "" "" "" "" "" "" "" "" "" "" "10.2" "7.8" "12.7" "9.6" "6.7" "8.6" "8.8" "7.0" "10.2" "24.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4765552648658305889" "False" "High" "IsMasterProtein" "Q96JH7" "Deubiquitinating protein VCPIP1 OS=Homo sapiens OX=9606 GN=VCPIP1 PE=1 SV=2" "0.000" "False" "5.944" "1" "1" "2" "1" "1222" "134.2" "7.20" "5.43" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02338, Pf19437, Pf21403" "80124" "ENSG00000175073" "VCPIP1" "hsa:80124; Q504T4; Q86T93; Q86W01; Q8N3A9; Q96JH7; Q9H5R8" "Alstrom syndrome" "Ovarian tumor domain proteases" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8104731299280243918" "False" "High" "IsMasterProtein" "Q4G148" "Glucoside xylosyltransferase 1 OS=Homo sapiens OX=9606 GN=GXYLT1 PE=1 SV=2" "0.000" "False" "5.944" "5" "2" "3" "2" "440" "50.5" "8.65" "6.15" "2" "protein metabolism;other metabolic processes" "other membranes" "other molecular function" "Pf01501" "283464" "ENSG00000151233" "GXYLT1" "B3KWJ2; hsa:283464; Q4G148; Q8IXV1; Q96BH4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3244624518097785869" "False" "High" "IsMasterProtein" "Q676U5" "Autophagy-related protein 16-1 OS=Homo sapiens OX=9606 GN=ATG16L1 PE=1 SV=2" "0.000" "False" "5.939" "3" "2" "2" "2" "607" "68.2" "6.64" "5.24" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400, Pf08614" "55054" "ENSG00000085978; ENSG00000281089" "ATG16L1" "A3EXK9; A3EXL0; B6ZDH0; hsa:55054; Q676U5; Q6IPN1; Q6UXW4; Q6ZVZ5; Q8NCY2; Q96JV5; Q9H619" "Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; LDLRAD4 and what we know about it; Autophagy; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6720248987179001386" "False" "High" "IsMasterProtein" "O60313" "Dynamin-like GTPase OPA1, mitochondrial OS=Homo sapiens OX=9606 GN=OPA1 PE=1 SV=3" "0.000" "False" "5.937" "2" "2" "2" "2" "960" "111.6" "7.87" "4.95" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00350, Pf19434" "4976" "ENSG00000198836" "OPA1" "D3DNW4; E5KLJ5; E5KLJ6; E5KLJ7; E5KLK1; E5KLK2; hsa:4976; O60313" "Orexin receptor pathway" "Mitochondrial protein degradation; Regulation of Apoptosis" "3" "0" "1.290" "0.822" "0.906" "1.183" "0.894" "1.065" "0.572" "1.030" "5.322" "20.1" "26.0" "16.5" "18.2" "23.8" "18.0" "21.4" "11.5" "20.7" "107.1" "" "" "" "" "" "" "" "" "" "" "12.0" "13.5" "9.2" "8.6" "11.0" "9.2" "10.0" "5.2" "11.2" "107.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1528073227460313936" "False" "High" "IsMasterProtein" "Q9H9T3" "Elongator complex protein 3 OS=Homo sapiens OX=9606 GN=ELP3 PE=1 SV=2" "0.000" "False" "5.930" "5" "3" "3" "3" "547" "62.2" "8.88" "7.24" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf04055, Pf16199" "55140" "ENSG00000134014" "ELP3" "B4DE19; B4DIG1; E2QRI5; hsa:55140; Q53G84; Q6AWB0; Q9BVF7; Q9H9T3; Q9NVZ1" "Ethanol effects on histone modifications; HDAC6 interactions in the central nervous system" "HATs acetylate histones" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2668424523932492370" "False" "High" "IsMasterProtein" "Q9BVQ7" "ATPase family gene 2 protein homolog B OS=Homo sapiens OX=9606 GN=AFG2B PE=1 SV=2" "0.000" "False" "5.918" "4" "2" "2" "2" "753" "80.7" "8.09" "1.67" "2" "other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00004, Pf17862" "79029" "ENSG00000171763" "AFG2B" "C9JHR5; hsa:79029; Q9BVQ7; Q9H8W7; Q9HA41" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8339310688111388996" "False" "High" "IsMasterProtein" "Q9HCE5" "N6-adenosine-methyltransferase non-catalytic subunit OS=Homo sapiens OX=9606 GN=METTL14 PE=1 SV=2" "0.000" "False" "5.916" "6" "3" "3" "3" "456" "52.1" "6.21" "4.12" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05063" "57721" "ENSG00000145388" "METTL14" "A6NIG1; hsa:57721; Q969V2; Q9HCE5" "1p36 copy number variation syndrome" "Processing of Capped Intron-Containing Pre-mRNA" "2" "0" "1.438" "1.207" "1.246" "1.087" "1.630" "0.933" "1.108" "1.185" "1.496" "50.2" "72.3" "60.6" "62.6" "54.6" "81.9" "46.9" "55.7" "59.5" "75.2" "" "" "" "" "" "" "" "" "" "" "30.1" "37.5" "33.6" "29.4" "25.3" "41.9" "21.8" "25.0" "32.3" "75.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3980690536672084448" "False" "High" "IsMasterProtein" "Q8NHV4" "Protein NEDD1 OS=Homo sapiens OX=9606 GN=NEDD1 PE=1 SV=1" "0.000" "False" "5.915" "3" "2" "2" "2" "660" "71.9" "7.97" "4.62" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00400" "121441" "ENSG00000139350" "NEDD1" "B0AZN0; B4E145; G3V3F1; hsa:121441; Q8NA30; Q8NHV4" "" "Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "1.105" "0.950" "0.897" "1.201" "1.068" "1.108" "1.018" "1.055" "1.193" "131.6" "145.4" "125.0" "118.1" "158.1" "140.5" "145.8" "133.9" "138.8" "157.0" "" "" "" "" "" "" "" "" "" "" "78.8" "75.6" "69.2" "55.5" "73.3" "71.9" "67.8" "60.1" "75.3" "157.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2292593222020041360" "False" "High" "IsMasterProtein" "Q92925" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 OS=Homo sapiens OX=9606 GN=SMARCD2 PE=1 SV=3" "0.000" "False" "5.891" "5" "2" "2" "2" "531" "58.9" "9.64" "6.39" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02201" "6603" "ENSG00000108604" "SMARCD2" "A5PLL5; A6NNQ7; B4DV56; B4E1R6; hsa:6603; Q7L2I6; Q92925; Q9UHZ1" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "6" "0" "1.051" "1.222" "1.149" "1.219" "1.108" "1.183" "1.109" "1.220" "2.669" "95.7" "100.6" "116.9" "110.0" "116.7" "106.1" "113.2" "106.2" "116.7" "255.5" "" "" "" "" "" "" "" "" "" "" "57.3" "52.3" "64.7" "51.6" "54.1" "54.3" "52.6" "47.7" "63.3" "255.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1657262686538344528" "False" "High" "IsMasterProtein" "O75717" "WD repeat and HMG-box DNA-binding protein 1 OS=Homo sapiens OX=9606 GN=WDHD1 PE=1 SV=1" "0.000" "False" "5.889" "1" "1" "2" "1" "1129" "125.9" "5.62" "4.43" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12341, Pf12894, Pf20946" "11169" "ENSG00000198554" "WDHD1" "C9JW18; F6W0U7; hsa:11169; O75717" "Mesodermal commitment pathway" "" "1" "0" "1.055" "0.926" "0.761" "0.935" "1.091" "0.733" "0.663" "1.091" "4.081" "21.2" "22.4" "19.6" "16.1" "19.8" "23.1" "15.5" "14.0" "23.1" "86.4" "" "" "" "" "" "" "" "" "" "" "12.7" "11.6" "10.9" "7.6" "9.2" "11.8" "7.2" "6.3" "12.5" "86.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4854644692515831998" "False" "High" "IsMasterProtein" "Q86X76" "Deaminated glutathione amidase OS=Homo sapiens OX=9606 GN=NIT1 PE=1 SV=2" "0.000" "False" "5.884" "7" "3" "5" "3" "327" "35.9" "7.74" "12.32" "3" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00795" "4817" "ENSG00000158793" "NIT1" "B1AQP3; D3DVF4; hsa:4817; O76091; Q86X76" "" "" "0" "0" "0.923" "0.915" "0.814" "0.924" "0.903" "1.026" "0.938" "1.072" "0.556" "310.4" "286.6" "283.9" "252.7" "286.7" "280.3" "318.5" "291.2" "332.6" "172.4" "" "" "" "" "" "" "" "" "" "" "185.7" "148.9" "157.2" "118.7" "132.9" "143.5" "148.1" "130.7" "180.5" "172.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3096317975956610268" "False" "High" "IsMasterProtein" "Q9HBL8" "NmrA-like family domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NMRAL1 PE=1 SV=1" "0.000" "False" "5.884" "8" "3" "3" "3" "299" "33.3" "7.52" "7.37" "3" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf05368" "57407" "ENSG00000153406; ENSG00000274684" "NMRAL1" "hsa:57407; Q9HBL8" "" "Urea cycle" "1" "0" "1.136" "1.074" "0.982" "1.116" "1.135" "1.203" "0.819" "1.140" "2.365" "74.8" "85.0" "80.4" "73.5" "83.5" "84.9" "90.0" "61.3" "85.3" "177.0" "" "" "" "" "" "" "" "" "" "" "44.8" "44.2" "44.5" "34.5" "38.7" "43.5" "41.9" "27.5" "46.3" "177.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3318017659961933117" "False" "High" "IsMasterProtein" "Q9NVA1" "Ubiquinol-cytochrome c reductase complex assembly factor 1 OS=Homo sapiens OX=9606 GN=UQCC1 PE=1 SV=3" "0.000" "False" "5.868" "6" "2" "2" "2" "299" "34.6" "8.91" "6.17" "2" "cell organization and biogenesis" "other membranes;mitochondrion;other cell component" "" "Pf03981" "55245" "ENSG00000101019" "UQCC1" "B1AKV5; hsa:55245; Q0VF37; Q5T348; Q5T351; Q5T353; Q86YU3; Q86YU4; Q96H66; Q9H438; Q9H452; Q9H9K8; Q9H9R5; Q9NVA1" "Ciliary landscape; Mitochondrial complex III assembly" "" "2" "0" "0.782" "0.837" "0.824" "0.836" "0.895" "0.941" "0.850" "0.925" "0.968" "152.6" "119.3" "127.7" "125.8" "127.7" "136.6" "143.6" "129.7" "141.2" "147.8" "" "" "" "" "" "" "" "" "" "" "91.4" "62.0" "70.7" "59.0" "59.2" "69.9" "66.8" "58.2" "76.6" "147.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "469142345215753577" "False" "High" "IsMasterProtein" "Q9Y2R9" "Small ribosomal subunit protein uS7m OS=Homo sapiens OX=9606 GN=MRPS7 PE=1 SV=2" "0.000" "False" "5.866" "6" "1" "1" "1" "242" "28.1" "9.99" "4.56" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00177" "51081" "ENSG00000125445" "MRPS7" "B2R9N5; hsa:51081; Q53GD6; Q9Y2R9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.949" "1.176" "0.951" "0.942" "1.154" "0.945" "1.389" "1.223" "1.528" "25.4" "24.1" "29.9" "24.1" "23.9" "29.3" "24.0" "35.3" "31.1" "38.8" "" "" "" "" "" "" "" "" "" "" "15.2" "12.5" "16.5" "11.3" "11.1" "15.0" "11.2" "15.8" "16.8" "38.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2544930509745837934" "False" "High" "IsMasterProtein" "P81877" "Single-stranded DNA-binding protein 2 OS=Homo sapiens OX=9606 GN=SSBP2 PE=1 SV=2" "0.000" "False" "5.843" "6" "2" "2" "2" "361" "37.8" "6.64" "4.42" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04503" "23635" "ENSG00000145687" "SSBP2" "B2R5W1; B7Z1J2; B7Z2L9; B7Z665; D6RH18; E9PB74; E9PDA8; hsa:23635; P81877; Q8N2Q2; Q9BWW6; Q9Y4T7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8889177674351520658" "False" "High" "IsMasterProtein" "Q8ND24" "RING finger protein 214 OS=Homo sapiens OX=9606 GN=RNF214 PE=1 SV=2" "0.000" "False" "5.841" "2" "1" "1" "1" "703" "77.6" "6.95" "3.26" "1" "" "" "other molecular function" "" "257160" "ENSG00000167257" "RNF214" "B2RUW0; B4DTD1; hsa:257160; Q8ND24" "" "" "0" "0" "1.025" "1.168" "1.099" "1.358" "0.899" "1.683" "1.163" "0.972" "2.048" "14.7" "15.1" "17.2" "16.2" "20.0" "13.3" "24.8" "17.1" "14.3" "30.2" "" "" "" "" "" "" "" "" "" "" "8.8" "7.8" "9.5" "7.6" "9.3" "6.8" "11.5" "7.7" "7.8" "30.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4687575668731336676" "False" "High" "IsMasterProtein" "Q6UX04" "Spliceosome-associated protein CWC27 homolog OS=Homo sapiens OX=9606 GN=CWC27 PE=1 SV=1" "0.000" "False" "5.832" "6" "2" "2" "2" "472" "53.8" "5.80" "5.48" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00160" "10283" "ENSG00000153015" "CWC27" "hsa:10283; O60529; O60530; Q6UX04; Q96EM3" "" "mRNA Splicing - Major Pathway" "1" "0" "1.146" "0.994" "1.052" "1.133" "0.929" "1.058" "1.151" "1.053" "2.186" "138.4" "158.6" "137.6" "145.5" "156.8" "128.6" "146.4" "159.3" "145.7" "302.5" "" "" "" "" "" "" "" "" "" "" "82.8" "82.4" "76.2" "68.3" "72.7" "65.8" "68.1" "71.5" "79.1" "302.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7719784497129908869" "False" "High" "IsMasterProtein" "O60566" "Mitotic checkpoint serine/threonine-protein kinase BUB1 beta OS=Homo sapiens OX=9606 GN=BUB1B PE=1 SV=3" "0.000" "False" "5.832" "2" "2" "2" "2" "1050" "119.5" "5.27" "4.78" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf08311" "701" "ENSG00000156970" "BUB1B" "B2R6U0; B4DL09; B4DLG3; hsa:701; O60501; O60566; O60627; O60758; O75389; Q59HH6; Q8WV50; Q96KM4" "Regulation of sister chromatid separation at the metaphase-anaphase transition; 10q22q23 copy number variation" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4410933930265088231" "False" "High" "IsMasterProtein" "P14927" "Cytochrome b-c1 complex subunit 7 OS=Homo sapiens OX=9606 GN=UQCRB PE=1 SV=2" "0.000" "False" "5.807" "10" "1" "1" "1" "111" "13.5" "8.78" "3.87" "1" "other metabolic processes" "other membranes;mitochondrion" "" "Pf02271" "7381" "ENSG00000156467" "UQCRB" "E5RJU0; hsa:7381; P14927; Q6FGD1" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "Respiratory electron transport" "4" "0" "0.855" "0.905" "0.955" "1.017" "0.917" "0.968" "1.064" "1.059" "0.458" "84.4" "72.2" "76.5" "80.6" "85.9" "77.4" "81.7" "89.9" "89.4" "38.6" "" "" "" "" "" "" "" "" "" "" "50.5" "37.5" "42.3" "37.8" "39.8" "39.6" "38.0" "40.3" "48.5" "38.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8682459872602538883" "False" "High" "IsMasterProtein" "Q8N108" "Mesoderm induction early response protein 1 OS=Homo sapiens OX=9606 GN=MIER1 PE=1 SV=2" "0.000" "False" "5.807" "4" "2" "2" "2" "512" "57.9" "4.42" "4.63" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf19426" "57708" "ENSG00000198160" "MIER1" "C9JFD4; hsa:57708; Q08AE0; Q32NC4; Q5T104; Q5TAD1; Q5TAD2; Q5TAD4; Q5TAD5; Q6AHY8; Q86TB4; Q8N108; Q8N156; Q8N161; Q8NC37; Q8NES4; Q8NES5; Q8NES6; Q8WWG2; Q9HCG2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7828842707520281021" "False" "High" "IsMasterProtein" "P41223" "Protein BUD31 homolog OS=Homo sapiens OX=9606 GN=BUD31 PE=1 SV=2" "0.000" "False" "5.807" "15" "2" "3" "2" "144" "17.0" "8.82" "8.23" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01125" "8896" "ENSG00000106245" "BUD31" "A4D274; B7Z4S9; D6W5S6; hsa:8896; P41223; Q6IB53; Q9UDV1" "" "mRNA Splicing - Major Pathway" "1" "0" "0.979" "0.923" "0.848" "1.125" "1.091" "1.030" "0.915" "1.005" "1.310" "256.4" "250.9" "236.5" "217.3" "288.4" "279.8" "264.2" "234.6" "257.7" "335.9" "" "" "" "" "" "" "" "" "" "" "153.4" "130.4" "131.0" "102.0" "133.7" "143.2" "122.8" "105.3" "139.8" "335.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3338073365584811594" "False" "High" "IsMasterProtein" "P83731" "Large ribosomal subunit protein eL24 OS=Homo sapiens OX=9606 GN=RPL24 PE=1 SV=1" "0.000" "False" "5.767" "13" "2" "2" "2" "157" "17.8" "11.25" "4.85" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01246" "6152" "ENSG00000114391" "RPL24" "B2R4Y3; hsa:6152; P38663; P83731; Q6IBS3" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.027" "1.133" "1.020" "1.049" "1.188" "1.024" "0.446" "1.201" "5.002" "107.5" "110.4" "121.9" "109.6" "112.8" "127.7" "110.2" "48.0" "129.1" "537.9" "" "" "" "" "" "" "" "" "" "" "64.4" "57.4" "67.5" "51.5" "52.3" "65.4" "51.2" "21.5" "70.0" "537.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2974219725755957834" "False" "High" "IsMasterProtein" "Q5HYJ3" "Protein FAM76B OS=Homo sapiens OX=9606 GN=FAM76B PE=1 SV=3" "0.000" "False" "5.762" "6" "2" "2" "2" "339" "38.7" "9.25" "5.28" "2" "" "nucleus" "" "Pf16046" "143684" "ENSG00000077458" "FAM76B" "B2R9C2; hsa:143684; Q5HYJ3; Q6PIU3; Q8TC53" "" "" "0" "0" "1.147" "1.063" "1.089" "1.128" "1.193" "1.474" "1.436" "1.116" "0.925" "78.8" "90.4" "83.8" "85.8" "88.9" "94.1" "116.2" "113.2" "88.0" "72.9" "" "" "" "" "" "" "" "" "" "" "47.2" "47.0" "46.4" "40.3" "41.2" "48.2" "54.0" "50.8" "47.7" "72.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2033130566960754114" "False" "High" "IsMasterProtein" "O95359" "Transforming acidic coiled-coil-containing protein 2 OS=Homo sapiens OX=9606 GN=TACC2 PE=1 SV=3" "0.000" "False" "5.748" "1" "3" "3" "1" "2948" "309.2" "4.79" "5.07" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05010" "10579" "ENSG00000138162" "TACC2" "hsa:10579; O95359; Q4VXL0; Q4VXL3; Q4VXL6; Q4VXL7; Q5U5T7; Q86WG6; Q86WG7; Q8TCK9; Q9BVQ1; Q9NZ41; Q9NZR5" "" "" "0" "0" "1.428" "1.376" "1.561" "1.779" "1.312" "1.747" "1.712" "1.932" "2.254" "18.6" "26.6" "25.7" "29.1" "33.2" "24.5" "32.6" "31.9" "36.0" "42.0" "" "" "" "" "" "" "" "" "" "" "11.2" "13.8" "14.2" "13.7" "15.4" "12.5" "15.1" "14.3" "19.5" "42.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2296645769357171248" "False" "High" "IsMasterProtein" "Q4G0J3" "La-related protein 7 OS=Homo sapiens OX=9606 GN=LARP7 PE=1 SV=1" "0.000" "False" "5.746" "4" "2" "2" "2" "582" "66.9" "9.55" "4.44" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf05383, Pf08777" "51574" "ENSG00000174720" "LARP7" "B2ZHN6; hsa:51574; Q3B7A9; Q4G0J3; Q9P1S7; Q9Y3Z8" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.258" "1.242" "0.750" "0.985" "1.250" "1.009" "0.134" "1.134" "5.047" "12.1" "15.2" "15.0" "9.1" "11.9" "15.1" "12.2" "1.6" "13.7" "60.9" "" "" "" "" "" "" "" "" "" "" "7.2" "7.9" "8.3" "4.3" "5.5" "7.7" "5.7" "0.7" "7.4" "60.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3150532128508731386" "False" "High" "IsMasterProtein" "O75554" "WW domain-binding protein 4 OS=Homo sapiens OX=9606 GN=WBP4 PE=1 SV=1" "0.000" "False" "5.745" "6" "2" "3" "2" "376" "42.5" "5.57" "5.03" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00397, Pf06220" "11193" "ENSG00000120688" "WBP4" "B7Z4M2; hsa:11193; O75554; Q32P29" "" "mRNA Splicing - Major Pathway" "1" "0" "0.927" "0.991" "1.134" "0.979" "0.990" "1.059" "1.033" "1.083" "0.452" "96.4" "89.4" "95.6" "109.3" "94.4" "95.4" "102.1" "99.6" "104.4" "43.6" "" "" "" "" "" "" "" "" "" "" "57.7" "46.5" "52.9" "51.3" "43.8" "48.9" "47.5" "44.7" "56.6" "43.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7159036767897580858" "False" "High" "IsMasterProtein" "P20036" "HLA class II histocompatibility antigen, DP alpha 1 chain OS=Homo sapiens OX=9606 GN=HLA-DPA1 PE=1 SV=1" "0.000" "False" "5.744" "5" "1" "1" "1" "260" "29.4" "5.21" "3.77" "1" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00993, Pf07654" "3113" "ENSG00000168384; ENSG00000206291; ENSG00000224103; ENSG00000228163; ENSG00000229685; ENSG00000231389; ENSG00000235844; ENSG00000236177" "HLA-DPA1" "A9YWH7; B9UKH4; O19722; O46883; P01905; P20036; P79554; Q2Q060; Q2Q061; Q5EY03; Q5STP1; Q6DQK4; Q9BCQ1; Q9TPX3; Q9XS10" "Allograft rejection; Ebola virus infection in host" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "9" "0" "1.055" "0.952" "0.993" "1.205" "1.022" "1.103" "1.054" "1.261" "0.660" "118.6" "125.1" "112.9" "117.8" "142.9" "121.1" "130.8" "125.0" "149.5" "78.2" "" "" "" "" "" "" "" "" "" "" "71.0" "65.0" "62.5" "55.3" "66.2" "62.0" "60.8" "56.1" "81.1" "78.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2350486907516670884" "False" "High" "IsMasterProtein" "Q7Z5K2" "Wings apart-like protein homolog OS=Homo sapiens OX=9606 GN=WAPL PE=1 SV=1" "0.000" "False" "5.741" "3" "2" "2" "2" "1190" "132.9" "5.44" "2.69" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07814" "23063" "ENSG00000062650" "WAPL" "A7E2B5; hsa:23063; Q5VSK5; Q7Z5K2; Q8IX10; Q92549" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "6" "0" "1.006" "1.121" "1.086" "1.249" "1.008" "0.945" "0.828" "1.106" "1.715" "70.3" "70.7" "78.8" "76.4" "87.8" "70.9" "66.5" "58.3" "77.8" "120.6" "" "" "" "" "" "" "" "" "" "" "42.1" "36.8" "43.6" "35.9" "40.7" "36.3" "30.9" "26.2" "42.2" "120.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6810289511595074622" "False" "High" "IsMasterProtein" "Q15758" "Neutral amino acid transporter B(0) OS=Homo sapiens OX=9606 GN=SLC1A5 PE=1 SV=2" "0.000" "False" "5.735" "4" "2" "3" "2" "541" "56.6" "5.48" "7.24" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;other molecular function" "Pf00375" "6510" "ENSG00000105281" "SLC1A5" "A8K9H5; B4DR77; B4DWS4; B7ZB81; D0EYG6; E9PC01; hsa:6510; O95720; Q15758; Q96RL9; Q9BWQ3; Q9UNP2" "TYROBP causal network in microglia; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Metabolic reprogramming in colon cancer; Ferroptosis; Amino acid metabolism in triple-negative breast cancer cells" "RHOQ GTPase cycle; RAC1 GTPase cycle; RHOH GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; Amino acid transport across the plasma membrane" "11" "0" "0.842" "0.810" "1.036" "0.895" "0.746" "1.006" "1.264" "1.069" "0.166" "39.6" "33.3" "32.0" "41.0" "35.4" "29.5" "39.8" "50.0" "42.3" "6.6" "" "" "" "" "" "" "" "" "" "" "23.7" "17.3" "17.7" "19.3" "16.4" "15.1" "18.5" "22.5" "23.0" "6.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7089722272324942505" "False" "High" "IsMasterProtein" "Q9NU23" "LYR motif-containing protein 2 OS=Homo sapiens OX=9606 GN=LYRM2 PE=1 SV=1" "0.000" "False" "5.725" "10" "2" "3" "2" "88" "10.4" "10.46" "8.03" "2" "cell organization and biogenesis" "mitochondrion" "" "Pf05347" "57226" "ENSG00000083099" "LYRM2" "B2R4U2; E1P517; hsa:57226; Q9NU23" "" "" "0" "0" "1.140" "1.195" "1.199" "1.214" "1.496" "1.272" "1.225" "1.382" "1.021" "70.5" "80.4" "84.2" "84.5" "85.6" "105.5" "89.7" "86.4" "97.4" "72.0" "" "" "" "" "" "" "" "" "" "" "42.2" "41.8" "46.6" "39.7" "39.7" "54.0" "41.7" "38.8" "52.9" "72.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-175071030841702515" "False" "High" "IsMasterProtein" "Q96N06" "Spermatogenesis-associated protein 33 OS=Homo sapiens OX=9606 GN=SPATA33 PE=1 SV=1" "0.000" "False" "5.713" "20" "2" "3" "2" "139" "15.5" "9.22" "4.39" "2" "cell organization and biogenesis;other metabolic processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "" "Pf15382" "124045" "ENSG00000167523" "SPATA33" "A8WFL2; B4DZN8; hsa:124045; Q96N06" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3559430331434459476" "False" "High" "IsMasterProtein" "O95630" "STAM-binding protein OS=Homo sapiens OX=9606 GN=STAMBP PE=1 SV=1" "0.000" "False" "5.707" "4" "2" "3" "2" "424" "48.0" "6.29" "5.96" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf01398, Pf08969" "10617" "ENSG00000124356" "STAMBP" "B5M0B6; D6W5H7; hsa:10617; O95630; Q3MJE7" "EGF/EGFR signaling pathway" "Metalloprotease DUBs" "2" "0" "1.351" "1.295" "1.407" "1.194" "1.181" "1.198" "1.008" "1.200" "2.904" "57.4" "77.5" "74.3" "80.7" "68.5" "67.7" "68.7" "57.8" "68.8" "166.5" "" "" "" "" "" "" "" "" "" "" "34.3" "40.3" "41.1" "37.9" "31.7" "34.7" "31.9" "26.0" "37.3" "166.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3037258603534985886" "False" "High" "IsMasterProtein" "Q12974" "Protein tyrosine phosphatase type IVA 2 OS=Homo sapiens OX=9606 GN=PTP4A2 PE=1 SV=1" "0.000" "False" "5.702" "9" "2" "3" "2" "167" "19.1" "8.37" "8.59" "2" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00102" "8073" "ENSG00000184007" "PTP4A2" "A8K9I8; B4DM39; D3DPP0; E9PGJ6; hsa:8073; O00649; Q12974; Q15197; Q15259; Q15260; Q15261; R4GN50" "" "RAB geranylgeranylation" "1" "0" "1.021" "1.135" "1.065" "1.045" "1.017" "0.944" "1.016" "1.079" "0.651" "215.0" "219.6" "244.1" "229.0" "224.6" "218.7" "203.0" "218.4" "231.9" "139.9" "" "" "" "" "" "" "" "" "" "" "128.7" "114.1" "135.2" "107.5" "104.1" "112.0" "94.4" "98.0" "125.8" "139.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5215276665585730267" "False" "High" "IsMasterProtein" "Q9BTD8" "RNA-binding protein 42 OS=Homo sapiens OX=9606 GN=RBM42 PE=1 SV=1" "0.000" "False" "5.700" "4" "2" "3" "2" "480" "50.4" "9.63" "8.35" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "79171" "ENSG00000126254" "RBM42" "hsa:79171; O00320; Q8N5R7; Q9BTD8; Q9BU66" "" "mRNA Splicing - Major Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7098201232450387464" "False" "High" "IsMasterProtein" "Q8N999" "RNA ligase 1 OS=Homo sapiens OX=9606 GN=RLIG1 PE=1 SV=2" "0.000" "False" "5.695" "3" "1" "6" "1" "325" "37.5" "7.06" "13.15" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "" "other molecular function" "Pf17720" "91298" "ENSG00000133641" "RLIG1" "Q569K5; Q6AWA8; Q6PEK5; Q8IYQ5; Q8N999; Q9NT75" "" "" "0" "0" "1.070" "1.045" "1.190" "1.063" "1.070" "1.013" "1.200" "1.145" "0.878" "355.3" "380.1" "371.2" "422.8" "377.8" "380.2" "359.8" "426.5" "406.8" "311.9" "" "" "" "" "" "" "" "" "" "" "212.6" "197.5" "205.6" "198.5" "175.1" "194.6" "167.3" "191.5" "220.7" "311.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1538396539459298741" "False" "High" "IsMasterProtein" "Q9H6Q4" "Cytosolic iron-sulfur assembly component 3 OS=Homo sapiens OX=9606 GN=CIAO3 PE=1 SV=1" "0.000" "False" "5.686" "4" "2" "2" "2" "476" "53.0" "7.23" "5.63" "2" "cell organization and biogenesis;stress response;other biological processes" "other cell component" "other molecular function" "Pf02256, Pf02906" "64428" "ENSG00000103245" "CIAO3" "A1L385; B3KTJ3; hsa:64428; Q53GC6; Q96S10; Q9H6J8; Q9H6Q4" "" "Cytosolic iron-sulfur cluster assembly" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3661455698439909776" "False" "High" "IsMasterProtein" "Q96AG4" "Leucine-rich repeat-containing protein 59 OS=Homo sapiens OX=9606 GN=LRRC59 PE=1 SV=1" "0.000" "False" "5.679" "5" "2" "2" "2" "307" "34.9" "9.57" "5.89" "2" "signal transduction" "other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "" "Pf13855" "55379" "ENSG00000108829" "LRRC59" "B2RE83; D3DTX8; hsa:55379; Q96AG4; Q9P189" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.976" "0.890" "0.960" "1.058" "0.987" "0.954" "1.052" "1.045" "0.446" "384.0" "374.8" "341.9" "368.6" "406.2" "379.1" "366.3" "403.9" "401.1" "171.4" "" "" "" "" "" "" "" "" "" "" "229.8" "194.8" "189.4" "173.0" "188.3" "194.1" "170.3" "181.3" "217.6" "171.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7957513769242835484" "False" "High" "IsMasterProtein" "Q9Y5S1" "Transient receptor potential cation channel subfamily V member 2 OS=Homo sapiens OX=9606 GN=TRPV2 PE=1 SV=1" "0.000" "False" "5.661" "2" "1" "2" "1" "764" "85.9" "5.83" "4.05" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00520, Pf12796" "51393" "ENSG00000187688" "TRPV2" "A6NML2; A8K0Z0; hsa:51393; Q9Y5S1; Q9Y670" "" "TRP channels" "1" "0" "0.940" "0.970" "1.015" "1.346" "0.979" "1.294" "1.432" "1.326" "1.528" "28.7" "27.0" "27.9" "29.2" "38.7" "28.1" "37.2" "41.1" "38.1" "43.9" "" "" "" "" "" "" "" "" "" "" "17.2" "14.0" "15.4" "13.7" "17.9" "14.4" "17.3" "18.5" "20.7" "43.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9003778122824522310" "False" "High" "IsMasterProtein" "Q9BRT3" "Migration and invasion enhancer 1 OS=Homo sapiens OX=9606 GN=MIEN1 PE=1 SV=1" "0.000" "False" "5.636" "10" "1" "1" "1" "115" "12.4" "4.37" "4.24" "1" "other biological processes" "plasma membrane;other membranes;cytosol" "" "Pf10262" "84299" "ENSG00000141741" "MIEN1" "hsa:84299; Q9BRT3" "17q12 copy number variation syndrome" "" "1" "0" "0.963" "1.075" "0.856" "0.856" "0.972" "0.883" "0.865" "1.031" "1.220" "95.3" "91.8" "102.5" "81.6" "81.6" "92.7" "84.2" "82.5" "98.3" "116.3" "" "" "" "" "" "" "" "" "" "" "57.0" "47.7" "56.7" "38.3" "37.8" "47.4" "39.1" "37.0" "53.3" "116.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2198906581928094734" "False" "High" "IsMasterProtein" "Q9BQC3" "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 OS=Homo sapiens OX=9606 GN=DPH2 PE=1 SV=1" "0.000" "False" "5.635" "4" "2" "2" "2" "489" "52.1" "5.53" "4.43" "2" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01866" "1802" "ENSG00000132768" "DPH2" "A8MVC9; B2RDE3; B4DNI8; hsa:1802; O60623; Q9BQC3" "" "Synthesis of diphthamide-EEF2" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4995074517937679177" "False" "High" "IsMasterProtein" "O95628" "CCR4-NOT transcription complex subunit 4 OS=Homo sapiens OX=9606 GN=CNOT4 PE=1 SV=3" "0.000" "False" "5.635" "3" "2" "3" "2" "575" "63.5" "7.03" "7.47" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00076, Pf14570" "4850" "ENSG00000080802" "CNOT4" "B7Z6I4; E7ET38; F8VQP3; O95339; O95627; O95628; Q8IYM7; Q8NCL0; Q9NPQ1; Q9NZN6" "" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "1.228" "1.322" "1.324" "1.388" "1.118" "1.246" "1.274" "1.003" "0.927" "61.3" "75.2" "81.0" "81.1" "85.1" "68.5" "76.4" "78.1" "61.4" "56.8" "" "" "" "" "" "" "" "" "" "" "36.7" "39.1" "44.9" "38.1" "39.4" "35.0" "35.5" "35.0" "33.3" "56.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6609542144732775052" "False" "High" "IsMasterProtein" "Q92615" "La-related protein 4B OS=Homo sapiens OX=9606 GN=LARP4B PE=1 SV=3" "0.000" "False" "5.634" "2" "2" "2" "2" "738" "80.5" "6.92" "4.99" "2" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05383" "23185" "ENSG00000107929" "LARP4B" "A7MD20; hsa:23185; Q5T3R3; Q5T3R4; Q5T3R5; Q68CY4; Q92615" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4135876604710417259" "False" "High" "IsMasterProtein" "P49593" "Protein phosphatase 1F OS=Homo sapiens OX=9606 GN=PPM1F PE=1 SV=3" "0.000" "False" "5.631" "7" "2" "2" "2" "454" "49.8" "5.10" "4.73" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00481" "9647" "ENSG00000100034" "PPM1F" "A8K6G3; B7Z2C3; hsa:9647; P49593; Q96PM2" "" "Negative regulation of NMDA receptor-mediated neuronal transmission" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7322766248926009386" "False" "High" "IsMasterProtein" "Q13564" "NEDD8-activating enzyme E1 regulatory subunit OS=Homo sapiens OX=9606 GN=NAE1 PE=1 SV=1" "0.000" "False" "5.629" "4" "2" "2" "2" "534" "60.2" "5.40" "5.46" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00899" "8883" "ENSG00000159593" "NAE1" "A6NCK0; A6NFN4; A8MU28; B2R700; B3KUP9; hsa:8883; Q13564" "Alzheimer's disease and miRNA effects; Hijack of ubiquitination by SARS-CoV-2; Alzheimer's disease" "Neddylation" "4" "0" "1.123" "1.359" "1.303" "1.414" "1.152" "1.341" "0.813" "0.982" "3.624" "98.0" "110.0" "133.2" "127.7" "138.6" "112.9" "131.4" "79.6" "96.2" "355.2" "" "" "" "" "" "" "" "" "" "" "58.7" "57.2" "73.8" "59.9" "64.3" "57.8" "61.1" "35.8" "52.2" "355.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3856989344168059657" "False" "High" "IsMasterProtein" "P04440" "HLA class II histocompatibility antigen, DP beta 1 chain OS=Homo sapiens OX=9606 GN=HLA-DPB1 PE=1 SV=1" "0.000" "False" "5.628" "6" "2" "4" "1" "258" "29.1" "8.57" "10.68" "2" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00969, Pf07654" "3115" "ENSG00000215048; ENSG00000223865; ENSG00000226826; ENSG00000230763; ENSG00000236693; ENSG00000237710" "HLA-DPB1" "A0PFJ7; A5I886; A8YPB3; B5U8B4; B7VF80; B7VF87; B8ZX68; B8ZYT0; B9W5S8; B9W6F7; B9W6F9; C0MPP5; C0MPQ2; C0MPQ3; C0MPQ5; C0MPQ6; C0MPQ7; C4R9J5; C5IZL1; hsa:3115; O00259; O19698; O19700; O19702; O19749; O46884; O77952; O98215; O98216; O98217; O98218; O98219; O98222; O98223; P01916; P04232; P04440; P13763; P79493; P79608; Q0P0L4; Q0ZFN3; Q14279; Q27S71; Q29682; Q29684; Q29698; Q29714; Q29775; Q29776; Q29778; Q29779; Q29781; Q29827; Q29828; Q29879; Q29880; Q29898; Q29977; Q2MGW3; Q30015; Q30031; Q30032; Q30033; Q30034; Q30050; Q30051; Q30052; Q30053; Q30054; Q30055; Q30174; Q4GY31; Q4JHD8; Q5ENE0; Q5ENE1; Q5ENW3; Q5EP46; Q5EP47; Q5EP49; Q5EP51; Q5EP52; Q5EP53; Q5EP56; Q5I4H8; Q5I4H9; Q5ISH4; Q5ISH5; Q5SQ73; Q5STP2; Q5YLA6; Q6IVX1; Q6LBX2; Q6LBX3; Q6LBX4; Q6LBX5; Q6LBX6; Q6LBX7; Q6PWX6; Q6TAS4; Q714U1; Q714U2; Q7YQ10; Q860Z7; Q8HWL7; Q8HWT5; Q8SNC4; Q95HC1; Q95IT7; Q95IT8; Q9BD13; Q9GIM2; Q9GIM4; Q9GIX6; Q9GJ41; Q9MY67; Q9TNT7; Q9TQE2; Q9XS11; Q9XS12" "Allograft rejection; Ebola virus infection in host" "MHC class II antigen presentation; Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; Interferon gamma signaling" "9" "0" "1.073" "1.075" "1.022" "0.972" "1.015" "1.022" "1.009" "0.952" "0.429" "217.0" "232.9" "233.2" "221.8" "210.8" "220.3" "221.7" "218.8" "206.5" "93.0" "" "" "" "" "" "" "" "" "" "" "129.8" "121.0" "129.2" "104.1" "97.7" "112.8" "103.1" "98.2" "112.1" "93.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1655251497259487415" "False" "High" "IsMasterProtein" "Q9BV38" "WD repeat-containing protein 18 OS=Homo sapiens OX=9606 GN=WDR18 PE=1 SV=2" "0.000" "False" "5.626" "4" "2" "3" "2" "432" "47.4" "6.70" "8.29" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf00400, Pf14077" "57418" "ENSG00000065268" "WDR18" "hsa:57418; O60390; Q9BV38; Q9BWR2" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2809797377402095157" "False" "High" "IsMasterProtein" "P42785" "Lysosomal Pro-X carboxypeptidase OS=Homo sapiens OX=9606 GN=PRCP PE=1 SV=1" "0.000" "False" "5.622" "6" "3" "3" "3" "496" "55.8" "7.21" "5.04" "3" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05577" "5547" "ENSG00000137509" "PRCP" "A8MU24; B2R7B7; B3KRK5; B5BU34; hsa:5547; P42785" "" "Intrinsic Pathway of Fibrin Clot Formation; Neutrophil degranulation" "2" "0" "1.143" "1.139" "1.256" "1.215" "1.031" "1.076" "1.016" "1.103" "0.803" "109.0" "124.5" "124.1" "136.9" "132.4" "112.4" "117.3" "110.8" "120.2" "87.5" "" "" "" "" "" "" "" "" "" "" "65.2" "64.7" "68.7" "64.3" "61.4" "57.5" "54.5" "49.7" "65.2" "87.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3786369172385558853" "False" "High" "IsMasterProtein" "P19388" "DNA-directed RNA polymerases I, II, and III subunit RPABC1 OS=Homo sapiens OX=9606 GN=POLR2E PE=1 SV=4" "0.000" "False" "5.602" "9" "2" "3" "2" "210" "24.5" "5.95" "7.11" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01191, Pf03871" "5434" "ENSG00000099817" "POLR2E" "B2R6L4; D6W5Y1; hsa:5434; O43380; P19388; Q6PIH5; Q9BT06" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "57" "0" "1.073" "1.120" "1.252" "1.091" "1.124" "1.199" "0.902" "1.119" "3.471" "96.6" "103.6" "108.2" "120.9" "105.4" "108.6" "115.9" "87.1" "108.1" "335.3" "" "" "" "" "" "" "" "" "" "" "57.8" "53.9" "59.9" "56.8" "48.9" "55.6" "53.9" "39.1" "58.6" "335.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2638301692080516805" "False" "High" "IsMasterProtein" "O95817" "BAG family molecular chaperone regulator 3 OS=Homo sapiens OX=9606 GN=BAG3 PE=1 SV=3" "0.000" "False" "5.602" "2" "1" "2" "1" "575" "61.6" "6.95" "4.47" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00397, Pf02179" "9531" "ENSG00000151929" "BAG3" "A8K5L8; hsa:9531; O95817; Q3B763; Q9NT20; Q9P120" "Cell interactions of the pancreatic cancer microenvironment" "Regulation of HSF1-mediated heat shock response" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4065169870199249389" "False" "High" "IsMasterProtein" "Q86VP1" "Tax1-binding protein 1 OS=Homo sapiens OX=9606 GN=TAX1BP1 PE=1 SV=2" "0.000" "False" "5.594" "2" "2" "2" "2" "789" "90.8" "5.43" "2.64" "2" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07888, Pf17751, Pf18112" "8887" "ENSG00000106052" "TAX1BP1" "A4D196; B4DKU7; E7ENV2; hsa:8887; O60398; O95770; Q13311; Q86VP1; Q9BQG5; Q9UI88" "" "Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling" "2" "0" "1.227" "0.987" "1.142" "1.594" "1.119" "1.136" "0.761" "1.003" "2.246" "72.9" "89.4" "72.0" "83.2" "116.2" "81.5" "82.8" "55.5" "73.1" "163.7" "" "" "" "" "" "" "" "" "" "" "43.6" "46.5" "39.9" "39.1" "53.9" "41.7" "38.5" "24.9" "39.7" "163.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1240749293216846131" "False" "High" "IsMasterProtein" "Q13526" "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 OS=Homo sapiens OX=9606 GN=PIN1 PE=1 SV=1" "0.000" "False" "5.588" "12" "1" "2" "1" "163" "18.2" "8.82" "4.97" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00397, Pf00639" "5300" "ENSG00000127445" "PIN1" "A8K4V9; hsa:5300; Q13526; Q53X75" "Novel intracellular components of RIG-I-like receptor pathway" "RHO GTPases Activate NADPH Oxidases; Regulation of TP53 Activity through Phosphorylation; ISG15 antiviral mechanism; Negative regulators of DDX58/IFIH1 signaling; PI5P Regulates TP53 Acetylation" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2272350597619465793" "False" "High" "IsMasterProtein" "O00743" "Serine/threonine-protein phosphatase 6 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP6C PE=1 SV=1" "0.000" "False" "5.581" "6" "2" "3" "2" "305" "35.1" "5.69" "8.34" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149" "5537" "ENSG00000119414" "PPP6C" "B2R5V6; B7Z2W9; B7Z5K9; hsa:5537; O00743; Q5U0A2; Q9UIC9" "" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "2" "0" "1.054" "0.956" "0.972" "0.916" "0.974" "1.138" "0.868" "1.242" "1.419" "126.0" "132.9" "120.4" "122.5" "115.4" "122.7" "143.4" "109.3" "156.5" "178.8" "" "" "" "" "" "" "" "" "" "" "75.4" "69.0" "66.7" "57.5" "53.5" "62.8" "66.7" "49.1" "84.9" "178.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9023891521044108187" "False" "High" "IsMasterProtein" "Q96BX8" "MOB kinase activator 3A OS=Homo sapiens OX=9606 GN=MOB3A PE=1 SV=1" "0.000" "False" "5.573" "11" "3" "3" "3" "217" "25.4" "8.63" "7.29" "3" "signal transduction;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03637" "126308" "ENSG00000172081" "MOB3A" "B3KTF1; hsa:126308; O75249; Q8TF69; Q96BX8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "776622353869952197" "False" "High" "IsMasterProtein" "O60262" "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 OS=Homo sapiens OX=9606 GN=GNG7 PE=1 SV=1" "0.000" "False" "5.564" "31" "2" "3" "2" "68" "7.5" "8.51" "8.64" "2" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00631" "2788" "ENSG00000176533" "GNG7" "B2R496; hsa:2788; O60262" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells" "G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "35" "0" "0.904" "0.866" "1.016" "0.969" "0.855" "1.005" "0.924" "1.071" "0.464" "145.5" "131.5" "126.0" "147.8" "141.0" "124.4" "146.2" "134.4" "155.8" "67.5" "" "" "" "" "" "" "" "" "" "" "87.1" "68.3" "69.8" "69.4" "65.3" "63.7" "68.0" "60.4" "84.5" "67.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5048841209035306562" "False" "High" "IsMasterProtein" "Q9H845" "Complex I assembly factor ACAD9, mitochondrial OS=Homo sapiens OX=9606 GN=ACAD9 PE=1 SV=1" "0.000" "False" "5.561" "5" "3" "3" "3" "621" "68.7" "7.96" "3.46" "3" "cell organization and biogenesis;other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00441, Pf02770, Pf02771, Pf21343" "28976" "ENSG00000177646" "ACAD9" "D3DNB8; hsa:28976; Q8WXX3; Q9H845" "Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "Complex I biogenesis" "3" "0" "1.096" "1.075" "1.073" "1.101" "1.062" "1.095" "0.885" "1.099" "3.085" "71.6" "78.5" "77.0" "76.9" "78.9" "76.1" "78.4" "63.4" "78.7" "221.0" "" "" "" "" "" "" "" "" "" "" "42.9" "40.8" "42.6" "36.1" "36.6" "39.0" "36.5" "28.5" "42.7" "221.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1798322026652807896" "False" "High" "IsMasterProtein" "Q5VTU8" "ATP synthase subunit epsilon-like protein, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1EP2 PE=1 SV=1" "0.000" "False" "5.557" "29" "2" "7" "2" "51" "5.8" "10.14" "20.98" "2" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf04627" "" "" "ATP5F1EP2" "Q5VTU8" "" "" "0" "0" "0.961" "0.988" "0.862" "1.005" "1.019" "0.961" "1.010" "1.024" "0.412" "1029.7" "989.9" "1017.0" "887.3" "1034.7" "1048.8" "989.6" "1039.8" "1054.1" "424.5" "" "" "" "" "" "" "" "" "" "" "616.2" "514.4" "563.2" "416.6" "479.6" "536.9" "460.1" "466.8" "571.9" "424.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3684476333316036577" "False" "High" "IsMasterProtein" "Q5R372" "Rab GTPase-activating protein 1-like OS=Homo sapiens OX=9606 GN=RABGAP1L PE=1 SV=1" "0.000" "False" "5.557" "3" "2" "2" "2" "815" "92.5" "5.31" "2.90" "2" "transport;other biological processes" "ER/Golgi;nucleus;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00566, Pf00640, Pf12473" "9910" "ENSG00000152061" "RABGAP1L" "O75059; Q3ZTR8; Q5R369; Q5R372; Q8IVV0; Q8N921; Q8WV78; Q9NSP8; Q9UQ19; Q9UQP5; Q9Y6Y5; Q9Y6Y6" "" "" "0" "0" "1.121" "1.217" "0.909" "0.784" "1.299" "1.321" "0.943" "1.257" "3.564" "34.1" "38.2" "41.5" "31.0" "26.7" "44.3" "45.0" "32.2" "42.8" "121.5" "" "" "" "" "" "" "" "" "" "" "20.4" "19.9" "23.0" "14.5" "12.4" "22.7" "20.9" "14.4" "23.2" "121.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3289873417268458662" "False" "High" "IsMasterProtein" "Q9NX40" "OCIA domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OCIAD1 PE=1 SV=1" "0.000" "False" "5.536" "7" "2" "3" "2" "245" "27.6" "7.49" "7.41" "2" "transport;other biological processes" "ER/Golgi;other cytoplasmic organelle" "" "Pf07051" "54940" "ENSG00000109180" "OCIAD1" "C9K030; G8JLN7; hsa:54940; Q9BZE8; Q9NX40" "" "" "0" "0" "0.958" "0.836" "0.806" "1.019" "0.853" "1.003" "1.005" "0.993" "0.516" "86.5" "82.9" "72.4" "69.8" "88.2" "73.8" "86.8" "87.0" "85.9" "44.7" "" "" "" "" "" "" "" "" "" "" "51.8" "43.1" "40.1" "32.8" "40.9" "37.8" "40.3" "39.1" "46.6" "44.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3305508852960409357" "False" "High" "IsMasterProtein" "Cont_Q7SIH1" "Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2" "0.000" "True" "5.529" "2" "2" "2" "2" "1510" "167.5" "6.02" "3.09" "2" "" "non-structural extracellular" "enzyme regulator activity;other molecular function" "Pf00207, Pf01835, Pf07677, Pf07678, Pf07703, Pf17789, Pf17791" "513856" "" "A2M" "A8E647; bta:513856; Q7SIH1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2016868097673482949" "False" "High" "IsMasterProtein" "Q9GZY6" "Linker for activation of T-cells family member 2 OS=Homo sapiens OX=9606 GN=LAT2 PE=1 SV=1" "0.000" "False" "5.519" "6" "1" "6" "1" "243" "26.5" "4.78" "4.45" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf15703" "7462" "ENSG00000086730" "LAT2" "A6NFK6; A8K209; A8K4F1; D3DXF9; hsa:7462; Q9BXX8; Q9GZY6; Q9NZY9" "B cell receptor signaling pathway; 7q11.23 copy number variation syndrome" "Role of LAT2/NTAL/LAB on calcium mobilization" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1583650821826420104" "False" "High" "IsMasterProtein" "Q9H9A5" "CCR4-NOT transcription complex subunit 10 OS=Homo sapiens OX=9606 GN=CNOT10 PE=1 SV=1" "0.000" "False" "5.517" "2" "1" "1" "1" "744" "82.3" "7.78" "2.91" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "" "25904" "ENSG00000182973; ENSG00000291502" "CNOT10" "B7Z7L1; F8WAF2; hsa:25904; Q9BU30; Q9H5J7; Q9H8X1; Q9H9A5; Q9H9W0; Q9HAH3; Q9UFJ2" "Ciliary landscape" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "4" "0" "1.173" "0.909" "0.760" "0.635" "1.609" "0.951" "1.451" "1.689" "7.929" "8.5" "10.0" "7.8" "6.5" "5.4" "13.7" "8.1" "12.4" "14.4" "67.7" "" "" "" "" "" "" "" "" "" "" "5.1" "5.2" "4.3" "3.0" "2.5" "7.0" "3.8" "5.6" "7.8" "67.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8472695818303021401" "False" "High" "IsMasterProtein" "P22087" "rRNA 2'-O-methyltransferase fibrillarin OS=Homo sapiens OX=9606 GN=FBL PE=1 SV=2" "0.000" "False" "5.514" "6" "2" "3" "2" "321" "33.8" "10.18" "7.77" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01269" "2091" "ENSG00000105202; ENSG00000280548" "FBL" "B5BUE8; hsa:2091; O75259; P22087; Q6IAT5; Q9UPI6" "Rubinstein-Taybi syndrome 1" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "3" "0" "0.987" "1.128" "1.175" "0.997" "0.973" "0.994" "1.065" "1.100" "1.047" "80.1" "79.0" "90.4" "94.1" "79.9" "77.9" "79.6" "85.3" "88.1" "83.8" "" "" "" "" "" "" "" "" "" "" "47.9" "41.1" "50.0" "44.2" "37.0" "39.9" "37.0" "38.3" "47.8" "83.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6049594169438393906" "False" "High" "IsMasterProtein" "Q52LJ0" "Protein FAM98B OS=Homo sapiens OX=9606 GN=FAM98B PE=1 SV=2" "0.000" "False" "5.512" "5" "2" "2" "2" "433" "45.5" "8.69" "5.16" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10239" "283742" "ENSG00000171262" "FAM98B" "A8MUW5; hsa:283742; Q52LJ0; Q8N935" "" "tRNA processing in the nucleus" "1" "0" "1.040" "0.927" "1.006" "1.031" "0.800" "1.146" "0.657" "1.242" "4.904" "76.6" "79.7" "71.1" "77.1" "79.0" "61.3" "87.8" "50.3" "95.1" "375.7" "" "" "" "" "" "" "" "" "" "" "45.9" "41.4" "39.4" "36.2" "36.6" "31.4" "40.8" "22.6" "51.6" "375.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-560084501499272066" "False" "High" "IsMasterProtein" "Q8IY18" "Structural maintenance of chromosomes protein 5 OS=Homo sapiens OX=9606 GN=SMC5 PE=1 SV=2" "0.000" "False" "5.509" "2" "2" "2" "2" "1101" "128.7" "8.38" "2.32" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463" "23137" "ENSG00000198887" "SMC5" "A6NM81; hsa:23137; O60335; Q05D92; Q5VZ60; Q8IY18; Q96SB9" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "1.066" "1.012" "0.990" "0.997" "0.927" "1.123" "0.938" "1.028" "2.124" "114.7" "122.3" "116.0" "113.6" "114.3" "106.3" "128.8" "107.6" "118.0" "243.6" "" "" "" "" "" "" "" "" "" "" "68.6" "63.5" "64.3" "53.3" "53.0" "54.4" "59.9" "48.3" "64.0" "243.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4447457189107336251" "False" "High" "IsMasterProtein" "O60493" "Sorting nexin-3 OS=Homo sapiens OX=9606 GN=SNX3 PE=1 SV=3" "0.000" "False" "5.501" "13" "2" "2" "1" "162" "18.8" "8.66" "4.90" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787" "8724" "ENSG00000112335" "SNX3" "A8K0B1; E1P5E4; E1P5E5; hsa:8724; O60493; O60718; Q4TT29; Q4TT31; Q5JXJ7; Q5JXJ8; Q96AP9; Q9C0J5; Q9NU45" "" "Ub-specific processing proteases; WNT ligand biogenesis and trafficking" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "Not Found" "High" "High" "Not Found" "High" "High" "1" "" "1812209145391096347" "False" "High" "IsMasterProtein" "P07919" "Cytochrome b-c1 complex subunit 6, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRH PE=1 SV=2" "0.000" "False" "5.488" "16" "2" "2" "2" "91" "10.7" "4.44" "7.00" "2" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf02320" "7388" "ENSG00000173660" "UQCRH" "B2R4V9; D3DQ18; hsa:7388; P07919; Q5TDF6; Q6LDB8; Q9BQ91" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "Respiratory electron transport" "4" "0" "0.952" "0.905" "0.901" "1.111" "0.957" "0.976" "0.956" "0.924" "0.295" "359.4" "342.1" "325.1" "323.7" "399.3" "344.0" "350.7" "343.7" "332.3" "105.9" "" "" "" "" "" "" "" "" "" "" "215.1" "177.8" "180.0" "152.0" "185.1" "176.1" "163.0" "154.3" "180.3" "105.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5364611794781451874" "False" "High" "IsMasterProtein" "P08575" "Receptor-type tyrosine-protein phosphatase C OS=Homo sapiens OX=9606 GN=PTPRC PE=1 SV=3" "0.000" "False" "5.458" "2" "2" "2" "2" "1306" "147.4" "6.15" "2.44" "2" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00041, Pf00102, Pf12453, Pf12567" "5788" "ENSG00000081237; ENSG00000262418" "PTPRC" "A0A0A0MT22; A8K7W6; hsa:5788; P08575; Q16614; Q9H0Y6; X6R433" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Regulatory circuits of the STAT3 signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; EPO receptor signaling; Interferon type I signaling pathways" "Neutrophil degranulation; Phosphorylation of CD3 and TCR zeta chains; Other semaphorin interactions" "9" "0" "0.943" "1.190" "1.070" "1.178" "0.980" "1.118" "1.117" "1.000" "1.180" "48.5" "45.7" "57.7" "51.9" "57.1" "47.5" "54.2" "54.2" "48.5" "57.2" "" "" "" "" "" "" "" "" "" "" "29.0" "23.8" "32.0" "24.4" "26.5" "24.3" "25.2" "24.3" "26.3" "57.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1630467620585670619" "False" "High" "IsMasterProtein" "Q9Y6K1" "DNA (cytosine-5)-methyltransferase 3A OS=Homo sapiens OX=9606 GN=DNMT3A PE=1 SV=4" "0.000" "False" "5.447" "2" "1" "1" "1" "912" "101.8" "6.57" "3.59" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00145, Pf00855, Pf17980, Pf21255" "1788" "ENSG00000119772" "DNMT3A" "E9PEB8; hsa:1788; Q86TE8; Q86XF5; Q8IZV0; Q8WXU9; Q9Y6K1" "One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; One-carbon metabolism and related pathways; MTHFR deficiency; Opioid receptor pathways; Spina bifida" "RMTs methylate histone arginines; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; SUMOylation of DNA methylation proteins" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3353134017530951509" "False" "High" "IsMasterProtein" "Q9Y5K5" "Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Homo sapiens OX=9606 GN=UCHL5 PE=1 SV=3" "0.000" "False" "5.440" "5" "1" "2" "1" "329" "37.6" "5.33" "3.37" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01088, Pf18031" "51377" "ENSG00000116750" "UCHL5" "hsa:51377; Q5LJA6; Q5LJA7; Q8TBS4; Q96BJ9; Q9H1W5; Q9P0I3; Q9UQN2; Q9Y5K5" "TGF-beta signaling pathway" "UCH proteinases; Downregulation of TGF-beta receptor signaling" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8611870974223822516" "False" "High" "IsMasterProtein" "Q8NHP8" "Putative phospholipase B-like 2 OS=Homo sapiens OX=9606 GN=PLBD2 PE=1 SV=2" "0.000" "False" "5.425" "4" "2" "2" "2" "589" "65.4" "6.80" "3.35" "2" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle" "other molecular function" "Pf04916" "196463" "ENSG00000151176" "PLBD2" "F5H5E2; hsa:196463; Q8NHP8" "" "" "0" "0" "1.149" "1.116" "0.927" "1.332" "1.237" "1.021" "0.921" "1.096" "0.627" "68.6" "78.9" "76.6" "63.6" "91.4" "84.9" "70.0" "63.2" "75.2" "43.0" "" "" "" "" "" "" "" "" "" "" "41.1" "41.0" "42.4" "29.9" "42.4" "43.4" "32.6" "28.4" "40.8" "43.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "289825156273590713" "False" "High" "IsMasterProtein" "Q5JTV8" "Torsin-1A-interacting protein 1 OS=Homo sapiens OX=9606 GN=TOR1AIP1 PE=1 SV=2" "0.000" "False" "5.405" "2" "1" "2" "1" "583" "66.2" "8.18" "7.30" "1" "cell organization and biogenesis;other biological processes" "other membranes;nucleus" "cytoskeletal activity;other molecular function" "Pf05609, Pf20443" "26092" "ENSG00000143337" "TOR1AIP1" "A0A0A0MSK5; A8K630; B0QZ57; hsa:26092; Q5JTV6; Q5JTV8; Q8IZ65; Q9H8Y6; Q9HAJ1; Q9NV52; Q9Y3X5" "Influence of laminopathies on Wnt signaling" "RHOF GTPase cycle; RHOD GTPase cycle" "3" "0" "1.291" "1.085" "1.061" "1.151" "1.152" "1.345" "1.359" "1.021" "0.623" "49.5" "63.9" "53.7" "52.5" "57.0" "57.1" "66.6" "67.3" "50.5" "30.9" "" "" "" "" "" "" "" "" "" "" "29.6" "33.2" "29.7" "24.7" "26.4" "29.2" "31.0" "30.2" "27.4" "30.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4697106387219567458" "False" "High" "IsMasterProtein" "Q6P2E9" "Enhancer of mRNA-decapping protein 4 OS=Homo sapiens OX=9606 GN=EDC4 PE=1 SV=1" "0.000" "False" "5.402" "2" "3" "3" "3" "1401" "151.6" "5.86" "2.11" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf16529, Pf21289" "23644" "ENSG00000038358" "EDC4" "A6NGM1; A8K4T4; hsa:23644; Q13025; Q13826; Q6P2E9; Q6ZR12; Q7Z6H7" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "0.930" "1.087" "1.151" "1.130" "0.832" "1.197" "0.771" "1.302" "2.456" "111.7" "103.8" "121.5" "128.6" "126.2" "93.0" "133.7" "86.1" "145.5" "274.3" "" "" "" "" "" "" "" "" "" "" "66.8" "54.0" "67.3" "60.4" "58.5" "47.6" "62.2" "38.7" "78.9" "274.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7694143023947037177" "False" "High" "IsMasterProtein" "Q96I15" "Selenocysteine lyase OS=Homo sapiens OX=9606 GN=SCLY PE=1 SV=4" "0.000" "False" "5.400" "6" "2" "2" "2" "445" "48.1" "7.12" "2.41" "2" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00266" "51540" "ENSG00000132330" "SCLY" "B9A068; hsa:51540; J3KN06; Q53SN1; Q53SN8; Q7L670; Q96I15; Q9NVT7; Q9NZR7" "Selenium metabolism and selenoproteins; 2q37 copy number variation syndrome" "Metabolism of ingested SeMet, Sec, MeSec into H2Se" "3" "0" "0.981" "1.148" "1.187" "1.135" "1.198" "1.040" "1.210" "1.024" "0.815" "71.9" "70.5" "82.5" "85.4" "81.6" "86.2" "74.8" "87.0" "73.6" "58.6" "" "" "" "" "" "" "" "" "" "" "43.0" "36.6" "45.7" "40.1" "37.8" "44.1" "34.8" "39.1" "39.9" "58.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6653202710982051878" "False" "High" "IsMasterProtein" "Q96RL1" "BRCA1-A complex subunit RAP80 OS=Homo sapiens OX=9606 GN=UIMC1 PE=1 SV=2" "0.000" "False" "5.400" "3" "2" "2" "2" "719" "79.7" "5.45" "2.24" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf18282" "51720" "ENSG00000087206" "UIMC1" "A8MSA1; B3KMZ1; B4E3N2; hsa:51720; Q5XKQ1; Q7Z3W7; Q8N5B9; Q96RL1; Q9BZR1; Q9BZR5; Q9UHX7" "5q35 copy number variation" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs" "6" "0" "1.029" "1.156" "0.952" "0.956" "0.962" "1.238" "1.192" "1.000" "1.017" "34.1" "35.1" "39.4" "32.5" "32.6" "32.8" "42.2" "40.6" "34.1" "34.7" "" "" "" "" "" "" "" "" "" "" "20.4" "18.2" "21.8" "15.2" "15.1" "16.8" "19.6" "18.2" "18.5" "34.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7101780835120275737" "False" "High" "IsMasterProtein" "Q9Y3Q8" "TSC22 domain family protein 4 OS=Homo sapiens OX=9606 GN=TSC22D4 PE=1 SV=2" "0.000" "False" "5.390" "5" "2" "4" "1" "395" "41.0" "7.21" "10.07" "2" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf01166" "81628" "ENSG00000166925" "TSC22D4" "A4D2C3; A8MWR6; D6W5V9; hsa:81628; Q9Y3Q8" "" "" "0" "0" "1.463" "2.060" "1.315" "1.602" "1.096" "1.409" "1.408" "1.520" "4.450" "16.6" "24.3" "34.2" "21.8" "26.6" "18.2" "23.4" "23.4" "25.2" "73.8" "" "" "" "" "" "" "" "" "" "" "9.9" "12.6" "18.9" "10.2" "12.3" "9.3" "10.9" "10.5" "13.7" "73.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7420075580370482485" "False" "High" "IsMasterProtein" "P14209" "CD99 antigen OS=Homo sapiens OX=9606 GN=CD99 PE=1 SV=1" "0.000" "False" "5.386" "13" "2" "2" "2" "185" "18.8" "4.75" "4.56" "2" "cell adhesion;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf12301" "4267" "ENSG00000002586; ENSG00000292348" "CD99" "A6NIW1; hsa:4267; O00518; P14209; Q6ICV7" "" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall" "2" "0" "1.289" "1.024" "1.021" "0.954" "1.007" "1.318" "1.369" "1.274" "0.659" "25.3" "32.6" "25.9" "25.9" "24.2" "25.5" "33.4" "34.7" "32.3" "16.7" "" "" "" "" "" "" "" "" "" "" "15.2" "17.0" "14.4" "12.1" "11.2" "13.1" "15.5" "15.6" "17.5" "16.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2647028449518715682" "False" "High" "IsMasterProtein" "P16383" "Intron Large complex component GCFC2 OS=Homo sapiens OX=9606 GN=GCFC2 PE=1 SV=2" "0.000" "False" "5.374" "3" "2" "3" "2" "781" "89.3" "5.99" "7.78" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf07842" "6936" "ENSG00000005436" "GCFC2" "A4UHQ8; A4UHQ9; hsa:6936; O95032; P16383; Q53TY0; Q6P2F2" "" "mRNA Splicing - Major Pathway" "1" "0" "1.054" "1.023" "1.172" "1.364" "1.125" "1.438" "1.171" "1.022" "1.080" "65.9" "69.5" "67.4" "77.3" "89.9" "74.2" "94.8" "77.3" "67.4" "71.2" "" "" "" "" "" "" "" "" "" "" "39.5" "36.1" "37.3" "36.3" "41.7" "38.0" "44.1" "34.7" "36.6" "71.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3585506896184313716" "False" "High" "IsMasterProtein" "P63218" "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 OS=Homo sapiens OX=9606 GN=GNG5 PE=1 SV=3" "0.000" "False" "5.373" "24" "2" "2" "2" "68" "7.3" "9.85" "4.95" "2" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00631" "2787" "ENSG00000174021" "GNG5" "B2R5A0; hsa:2787; P30670; P63218; Q5VX54; Q61015" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells; Pathways in cancer" "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "36" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3563159699507819169" "False" "High" "IsMasterProtein" "P06280" "Alpha-galactosidase A OS=Homo sapiens OX=9606 GN=GLA PE=1 SV=1" "0.000" "False" "5.363" "5" "2" "2" "2" "429" "48.7" "5.60" "3.68" "2" "other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf16499, Pf17450" "2717" "ENSG00000102393" "GLA" "hsa:2717; P06280; Q6LER7" "Degradation pathway of sphingolipids, including diseases; Ciliary landscape" "Neutrophil degranulation; Glycosphingolipid catabolism" "4" "0" "1.165" "0.734" "0.757" "1.157" "0.958" "1.242" "1.179" "0.974" "0.693" "20.6" "24.0" "15.1" "15.6" "23.8" "19.7" "25.6" "24.3" "20.0" "14.3" "" "" "" "" "" "" "" "" "" "" "12.3" "12.5" "8.4" "7.3" "11.0" "10.1" "11.9" "10.9" "10.9" "14.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2849598886551382800" "False" "High" "IsMasterProtein" "Q9P2K5" "Myelin expression factor 2 OS=Homo sapiens OX=9606 GN=MYEF2 PE=1 SV=3" "0.000" "False" "5.350" "5" "2" "2" "2" "600" "64.1" "8.75" "5.37" "2" "developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076" "50804" "ENSG00000104177" "MYEF2" "A7MCZ9; C9J921; C9K0J4; hsa:50804; Q6NUM5; Q7L388; Q7Z4B7; Q9H922; Q9NUQ1; Q9P2K5" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Mitochondrial gene expression" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8490030146092636123" "False" "High" "IsMasterProtein" "Q7Z422" "SUZ RNA-binding domain-containing OS=Homo sapiens OX=9606 GN=SZRD1 PE=1 SV=1" "0.000" "False" "5.343" "11" "2" "2" "2" "152" "17.0" "8.95" "5.60" "2" "" "" "" "Pf12752, Pf12901" "26099" "ENSG00000055070; ENSG00000291379" "SZRD1" "A8MXJ2; C9K0U0; hsa:26099; Q7Z422; Q7Z424; Q8IVM2; Q8TBV3; Q9Y403" "" "" "0" "0" "1.076" "1.052" "0.962" "0.985" "0.867" "1.012" "0.976" "0.824" "0.412" "120.1" "129.2" "126.3" "115.6" "118.3" "104.1" "121.5" "117.3" "98.9" "49.5" "" "" "" "" "" "" "" "" "" "" "71.9" "67.1" "69.9" "54.2" "54.8" "53.3" "56.5" "52.6" "53.7" "49.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5775237487534858758" "False" "High" "IsMasterProtein" "P62750" "Large ribosomal subunit protein uL23 OS=Homo sapiens OX=9606 GN=RPL23A PE=1 SV=1" "0.000" "False" "5.342" "10" "2" "2" "2" "156" "17.7" "10.45" "5.94" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00276, Pf03939" "6147" "ENSG00000198242" "RPL23A" "B2R5B2; hsa:6147; P29316; P39024; P62750; Q92774" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.307" "0.987" "1.100" "1.091" "1.338" "1.070" "0.833" "1.065" "1.529" "231.5" "302.6" "228.4" "254.7" "252.5" "309.8" "247.7" "192.9" "246.7" "354.0" "" "" "" "" "" "" "" "" "" "" "138.6" "157.3" "126.5" "119.6" "117.0" "158.6" "115.2" "86.6" "133.8" "354.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8782034775898615298" "False" "High" "IsMasterProtein" "Q96NC0" "Zinc finger matrin-type protein 2 OS=Homo sapiens OX=9606 GN=ZMAT2 PE=1 SV=1" "0.000" "False" "5.338" "11" "3" "5" "3" "199" "23.6" "9.01" "15.14" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf12171" "153527" "ENSG00000146007" "ZMAT2" "hsa:153527; Q96NC0" "" "mRNA Splicing - Major Pathway" "1" "0" "0.998" "0.972" "0.848" "1.005" "1.051" "1.012" "1.092" "1.035" "0.391" "447.1" "446.3" "434.5" "379.2" "449.4" "470.0" "452.7" "488.3" "462.8" "174.9" "" "" "" "" "" "" "" "" "" "" "267.6" "231.9" "240.6" "178.0" "208.3" "240.6" "210.5" "219.2" "251.1" "174.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5403362594162546688" "False" "High" "IsMasterProtein" "Q15007" "Pre-mRNA-splicing regulator WTAP OS=Homo sapiens OX=9606 GN=WTAP PE=1 SV=2" "0.000" "False" "5.332" "4" "1" "1" "1" "396" "44.2" "5.19" "2.68" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf17098" "9589" "ENSG00000146457" "WTAP" "hsa:9589; Q15007; Q5TCL8; Q5TCL9; Q96T28; Q9BYJ7; Q9H4E2" "" "Processing of Capped Intron-Containing Pre-mRNA" "1" "0" "1.077" "1.002" "0.929" "1.279" "0.709" "1.027" "0.868" "0.832" "1.920" "21.4" "23.0" "21.5" "19.9" "27.4" "15.2" "22.0" "18.6" "17.8" "41.1" "" "" "" "" "" "" "" "" "" "" "12.8" "12.0" "11.9" "9.3" "12.7" "7.8" "10.2" "8.3" "9.7" "41.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "456544607600152383" "False" "High" "IsMasterProtein" "Q9UJY5" "ADP-ribosylation factor-binding protein GGA1 OS=Homo sapiens OX=9606 GN=GGA1 PE=1 SV=1" "0.000" "False" "5.331" "3" "3" "3" "2" "639" "70.3" "5.29" "4.37" "3" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "26088" "ENSG00000100083" "GGA1" "A8K3D3; B0QYR7; hsa:26088; Q5R3N1; Q5TG07; Q6IC75; Q86YA9; Q8NCS6; Q9BW94; Q9UG00; Q9UGW0; Q9UGW1; Q9UJY5" "" "Amyloid fiber formation; TBC/RABGAPs" "2" "0" "1.211" "1.251" "1.105" "1.119" "1.020" "1.138" "0.727" "1.213" "2.533" "91.6" "110.9" "114.6" "101.3" "102.5" "93.5" "104.3" "66.6" "111.2" "232.1" "" "" "" "" "" "" "" "" "" "" "54.8" "57.7" "63.4" "47.5" "47.5" "47.9" "48.5" "29.9" "60.3" "232.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5950667386624240413" "False" "High" "IsMasterProtein" "Q01082" "Spectrin beta chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTBN1 PE=1 SV=2" "0.000" "False" "5.330" "1" "2" "2" "2" "2364" "274.4" "5.57" "4.78" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00307, Pf00435" "6711" "ENSG00000115306" "SPTBN1" "B2RP63; hsa:6711; O60837; Q01082; Q16057; Q53R99; Q59ER3; Q8IX99" "TGF-beta signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "COPI-mediated anterograde transport; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; Signaling by FLT3 fusion proteins" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3241628752191747033" "False" "High" "IsMasterProtein" "Q9Y6W3" "Calpain-7 OS=Homo sapiens OX=9606 GN=CAPN7 PE=1 SV=1" "0.000" "False" "5.324" "2" "2" "2" "2" "813" "92.6" "7.65" "5.00" "2" "protein metabolism;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00648, Pf01067, Pf04212" "23473" "ENSG00000131375" "CAPN7" "hsa:23473; Q9Y6W3" "Integrin-mediated cell adhesion" "Degradation of the extracellular matrix" "2" "0" "1.050" "0.768" "1.264" "1.110" "1.563" "0.849" "0.956" "1.252" "5.016" "18.0" "18.9" "13.8" "22.7" "20.0" "28.1" "15.3" "17.2" "22.5" "90.3" "" "" "" "" "" "" "" "" "" "" "10.8" "9.8" "7.7" "10.7" "9.3" "14.4" "7.1" "7.7" "12.2" "90.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4235790517375748562" "False" "High" "IsMasterProtein" "O43924" "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta OS=Homo sapiens OX=9606 GN=PDE6D PE=1 SV=1" "0.000" "False" "5.323" "8" "1" "1" "1" "150" "17.4" "5.67" "4.07" "1" "other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf05351" "5147" "ENSG00000156973" "PDE6D" "hsa:5147; O43250; O43924" "Phosphodiesterases in neuronal function; Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "ARL13B-mediated ciliary trafficking of INPP5E; RAS processing" "6" "0" "0.796" "0.778" "1.079" "0.984" "1.040" "1.225" "1.081" "1.153" "0.923" "90.7" "72.1" "70.5" "97.8" "89.2" "94.3" "111.1" "98.0" "104.6" "83.7" "" "" "" "" "" "" "" "" "" "" "54.3" "37.5" "39.0" "45.9" "41.4" "48.3" "51.6" "44.0" "56.7" "83.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4348390061636338319" "False" "High" "IsMasterProtein" "Q9HAW4" "Claspin OS=Homo sapiens OX=9606 GN=CLSPN PE=1 SV=3" "0.000" "False" "5.323" "1" "2" "2" "2" "1339" "151.0" "4.82" "4.94" "2" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "" "63967" "ENSG00000092853" "CLSPN" "A6NFL4; hsa:63967; Q1RMC6; Q2KHM3; Q5VYG0; Q6P6H5; Q8IWI1; Q9HAW4" "" "Activation of ATR in response to replication stress; Ub-specific processing proteases; Processing of DNA double-strand break ends; Apoptotic cleavage of cellular proteins" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "947873724462567429" "False" "High" "IsMasterProtein" "Q9UNQ2" "Dimethyladenosine transferase OS=Homo sapiens OX=9606 GN=DIMT1 PE=1 SV=1" "0.000" "False" "5.320" "5" "2" "2" "2" "313" "35.2" "9.99" "5.00" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00398" "27292" "ENSG00000086189" "DIMT1" "O76025; Q9BU77; Q9UES1; Q9UNQ2" "" "rRNA modification in the nucleus and cytosol" "1" "0" "1.103" "1.132" "1.026" "1.059" "1.267" "1.001" "0.926" "1.026" "1.233" "70.7" "78.0" "80.0" "72.5" "74.9" "89.6" "70.8" "65.5" "72.6" "87.2" "" "" "" "" "" "" "" "" "" "" "42.3" "40.5" "44.3" "34.1" "34.7" "45.9" "32.9" "29.4" "39.4" "87.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3472433998448837783" "False" "High" "IsMasterProtein" "O75323" "Protein NipSnap homolog 2 OS=Homo sapiens OX=9606 GN=NIPSNAP2 PE=1 SV=1" "0.000" "False" "5.318" "6" "2" "3" "2" "286" "33.7" "9.36" "8.51" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;mitochondrion" "" "Pf07978" "2631" "ENSG00000146729" "NIPSNAP2" "C9IYJ3; hsa:2631; O43801; O75323; Q53X96" "" "RHOJ GTPase cycle; RHOH GTPase cycle" "2" "0" "1.028" "0.960" "0.893" "1.025" "1.155" "0.883" "0.946" "1.094" "0.744" "121.4" "124.7" "116.5" "108.4" "124.4" "140.2" "107.1" "114.8" "132.8" "90.3" "" "" "" "" "" "" "" "" "" "" "72.6" "64.8" "64.5" "50.9" "57.7" "71.8" "49.8" "51.5" "72.0" "90.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6271910638518906992" "False" "High" "IsMasterProtein" "Q92552" "Small ribosomal subunit protein mS27 OS=Homo sapiens OX=9606 GN=MRPS27 PE=1 SV=3" "0.000" "False" "5.317" "6" "1" "1" "1" "414" "47.6" "6.18" "3.25" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf10037" "23107" "ENSG00000113048" "MRPS27" "B4DRT2; hsa:23107; Q6P1S1; Q92552" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "Not Found" "High" "Not Found" "Not Found" "High" "Not Found" "High" "High" "1" "" "4832137807520605002" "False" "High" "IsMasterProtein" "O60934" "Nibrin OS=Homo sapiens OX=9606 GN=NBN PE=1 SV=1" "0.000" "False" "5.309" "4" "3" "5" "3" "754" "84.9" "6.90" "7.71" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00498, Pf00533, Pf08599, Pf16508" "4683" "ENSG00000104320" "NBN" "B2R626; B2RNC5; hsa:4683; O60672; O60934; Q32NF7; Q53FM6; Q63HR6; Q7LDM2" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Primary ovarian insufficiency; DNA damage response" "Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks" "29" "0" "0.903" "0.977" "1.235" "1.097" "0.995" "1.139" "0.828" "1.006" "2.986" "70.1" "63.3" "68.5" "86.6" "76.9" "69.8" "79.9" "58.0" "70.5" "209.4" "" "" "" "" "" "" "" "" "" "" "42.0" "32.9" "37.9" "40.7" "35.6" "35.7" "37.1" "26.1" "38.3" "209.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8439683798465219975" "False" "High" "IsMasterProtein" "P08621" "U1 small nuclear ribonucleoprotein 70 kDa OS=Homo sapiens OX=9606 GN=SNRNP70 PE=1 SV=2" "0.000" "False" "5.300" "4" "2" "2" "2" "437" "51.5" "9.94" "4.54" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf12220" "6625" "ENSG00000104852" "SNRNP70" "B3KUA3; hsa:6625; P08621; P78493; P78494; Q15364; Q15686; Q15687; Q15689; Q99377; Q9UE45; Q9UE46; Q9UE47; Q9UE48; Q9UFQ6" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.975" "0.810" "0.999" "1.260" "1.008" "0.906" "0.913" "0.916" "2.706" "62.9" "61.3" "50.9" "62.8" "79.3" "63.4" "57.0" "57.5" "57.6" "170.2" "" "" "" "" "" "" "" "" "" "" "37.6" "31.9" "28.2" "29.5" "36.7" "32.5" "26.5" "25.8" "31.3" "170.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4024286234021820395" "False" "High" "IsMasterProtein" "P78406" "mRNA export factor RAE1 OS=Homo sapiens OX=9606 GN=RAE1 PE=1 SV=1" "0.000" "False" "5.295" "7" "2" "2" "2" "368" "40.9" "7.83" "4.81" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00400" "8480" "ENSG00000101146" "RAE1" "A8K882; hsa:8480; O15306; P78406; Q3SYL7; Q5TCH8; Q6V708; Q9H100; Q9NQM6" "IL-18 signaling pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus" "30" "0" "1.080" "0.954" "1.397" "1.495" "0.993" "1.017" "1.178" "1.162" "1.090" "17.7" "19.1" "16.9" "24.7" "26.4" "17.6" "18.0" "20.8" "20.6" "19.3" "" "" "" "" "" "" "" "" "" "" "10.6" "9.9" "9.3" "11.6" "12.3" "9.0" "8.4" "9.4" "11.2" "19.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1339372435308816495" "False" "High" "IsMasterProtein" "Q8IWT0" "Protein archease OS=Homo sapiens OX=9606 GN=ZBTB8OS PE=1 SV=2" "0.000" "False" "5.291" "5" "1" "2" "1" "167" "19.5" "4.49" "5.12" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf01951" "339487" "ENSG00000176261" "ZBTB8OS" "hsa:339487; Q5TGK5; Q6PDA1; Q8IWS9; Q8IWT0; Q8NEV6; Q8NEV7" "" "tRNA processing in the nucleus" "1" "0" "1.049" "0.992" "0.995" "1.146" "1.044" "0.884" "1.031" "0.985" "1.052" "133.0" "139.5" "131.9" "132.2" "152.4" "138.8" "117.5" "137.0" "130.9" "139.9" "" "" "" "" "" "" "" "" "" "" "79.6" "72.5" "73.0" "62.1" "70.7" "71.1" "54.6" "61.5" "71.0" "139.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8311044657227682609" "False" "High" "IsMasterProtein" "Q9BZE9" "Tether containing UBX domain for GLUT4 OS=Homo sapiens OX=9606 GN=ASPSCR1 PE=1 SV=1" "0.000" "False" "5.283" "6" "2" "2" "2" "553" "60.1" "6.64" "2.91" "2" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf00789, Pf11470" "79058" "ENSG00000169696" "ASPSCR1" "A8K3K9; hsa:79058; Q7Z6N7; Q8WV59; Q96LS5; Q96M40; Q9BZE9" "" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "1" "0" "1.203" "1.067" "1.316" "1.590" "1.720" "1.664" "1.262" "1.192" "2.689" "27.2" "32.7" "29.0" "35.8" "43.2" "46.7" "45.2" "34.3" "32.4" "73.0" "" "" "" "" "" "" "" "" "" "" "16.3" "17.0" "16.1" "16.8" "20.0" "23.9" "21.0" "15.4" "17.6" "73.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5693736025540312441" "False" "High" "IsMasterProtein" "P0CG12" "Decreased expression in renal and prostate cancer protein OS=Homo sapiens OX=9606 GN=DERPC PE=1 SV=1" "0.000" "False" "5.279" "2" "1" "1" "1" "524" "51.4" "12.41" "3.39" "1" "" "nucleus" "" "" "" "ENSG00000286140" "DERPC" "A8MYX8; P0CG12; Q71E72; Q8NDH8; Q8WV66; Q9NX73" "" "" "0" "0" "1.046" "0.997" "1.008" "0.977" "0.884" "1.307" "0.837" "0.982" "0.615" "62.4" "65.2" "62.2" "62.9" "60.9" "55.1" "81.5" "52.2" "61.2" "38.4" "" "" "" "" "" "" "" "" "" "" "37.3" "33.9" "34.4" "29.5" "28.2" "28.2" "37.9" "23.4" "33.2" "38.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8376641896775859350" "False" "High" "IsMasterProtein" "O95104" "SR-related and CTD-associated factor 4 OS=Homo sapiens OX=9606 GN=SCAF4 PE=1 SV=3" "0.000" "False" "5.279" "3" "3" "3" "3" "1147" "125.8" "9.55" "5.87" "3" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf04818" "57466" "ENSG00000156304" "SCAF4" "C9JLZ0; hsa:57466; O95104; Q0P5W8; Q6P1M5; Q8N3I8; Q9UFM1; Q9ULP8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4672476971480337418" "False" "High" "IsMasterProtein" "P67870" "Casein kinase II subunit beta OS=Homo sapiens OX=9606 GN=CSNK2B PE=1 SV=1" "0.000" "False" "5.278" "9" "2" "7" "2" "215" "24.9" "5.55" "23.07" "2" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf01214" "1460" "ENSG00000204435; ENSG00000206406; ENSG00000224398; ENSG00000224774; ENSG00000228875; ENSG00000230700; ENSG00000232960" "CSNK2B" "B0UXA9; hsa:1460; P07312; P13862; P67870; Q4VX47" "Alzheimer's disease and miRNA effects; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Measles virus infection; Pleural mesothelioma; Alzheimer's disease; HDAC6 interactions in the central nervous system" "Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Neutrophil degranulation; Condensation of Prometaphase Chromosomes; Regulation of TP53 Activity through Phosphorylation; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Synthesis of PC" "21" "0" "0.938" "0.970" "1.074" "1.028" "1.041" "1.069" "0.864" "0.984" "1.852" "206.2" "193.5" "199.9" "221.5" "211.9" "214.7" "220.4" "178.2" "202.8" "381.9" "" "" "" "" "" "" "" "" "" "" "123.4" "100.6" "110.7" "104.0" "98.2" "109.9" "102.5" "80.0" "110.0" "381.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1610110799858015964" "False" "High" "IsMasterProtein" "P20674" "Cytochrome c oxidase subunit 5A, mitochondrial OS=Homo sapiens OX=9606 GN=COX5A PE=1 SV=2" "0.000" "False" "5.263" "11" "2" "11" "2" "150" "16.8" "6.79" "29.68" "2" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02284" "9377" "ENSG00000178741" "COX5A" "hsa:9377; P20674; P30045; Q8TB65" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation; Arachidonate epoxygenase / epoxide hydrolase" "Respiratory electron transport; Mitochondrial protein degradation; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "9" "0" "0.954" "0.917" "1.149" "1.087" "0.986" "1.175" "1.109" "0.973" "1.104" "647.3" "617.6" "593.4" "743.7" "703.5" "638.2" "760.8" "717.6" "629.7" "714.5" "" "" "" "" "" "" "" "" "" "" "387.4" "321.0" "328.6" "349.1" "326.1" "326.7" "353.8" "322.2" "341.6" "714.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1630432664316486602" "False" "High" "IsMasterProtein" "Q16563" "Synaptophysin-like protein 1 OS=Homo sapiens OX=9606 GN=SYPL1 PE=1 SV=1" "0.000" "False" "5.250" "4" "1" "1" "1" "259" "28.5" "8.43" "3.78" "1" "cell-cell signaling" "plasma membrane;other membranes;ER/Golgi;other cell component" "" "Pf01284" "6856" "ENSG00000008282" "SYPL1" "A4D0R2; hsa:6856; Q16563; Q96AR8" "" "" "0" "0" "0.762" "0.714" "0.573" "1.080" "0.799" "1.057" "0.588" "1.262" "0.772" "103.1" "78.6" "73.6" "59.1" "111.4" "82.4" "109.0" "60.6" "130.2" "79.6" "" "" "" "" "" "" "" "" "" "" "61.7" "40.9" "40.8" "27.8" "51.6" "42.2" "50.7" "27.2" "70.6" "79.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2257664793413269493" "False" "High" "IsMasterProtein" "Q69YN2" "CWF19-like protein 1 OS=Homo sapiens OX=9606 GN=CWF19L1 PE=1 SV=2" "0.000" "False" "5.241" "4" "2" "2" "2" "538" "60.6" "7.24" "4.65" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "enzyme regulator activity" "Pf04676, Pf04677" "55280" "ENSG00000095485" "CWF19L1" "B4DHX1; D3DR66; hsa:55280; Q5W0I3; Q69YN2; Q96HC3; Q9H865; Q9NV13" "" "" "0" "0" "0.871" "0.856" "1.036" "1.028" "0.889" "0.972" "0.886" "0.997" "2.508" "81.2" "70.7" "69.5" "84.1" "83.5" "72.2" "79.0" "72.0" "81.0" "203.7" "" "" "" "" "" "" "" "" "" "" "48.6" "36.7" "38.5" "39.5" "38.7" "37.0" "36.7" "32.3" "43.9" "203.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "157541479094675987" "False" "High" "IsMasterProtein" "Q96AB3" "Isochorismatase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ISOC2 PE=1 SV=1" "0.000" "False" "5.236" "7" "1" "1" "1" "205" "22.3" "7.77" "4.11" "1" "other biological processes" "nucleus;other cell component" "" "Pf00857" "79763" "ENSG00000063241" "ISOC2" "hsa:79763; Q6ZN91; Q96AB3; Q9H5G0" "" "" "0" "0" "0.822" "1.001" "1.018" "1.243" "1.150" "1.077" "1.358" "1.143" "0.878" "32.1" "26.4" "32.2" "32.7" "39.9" "37.0" "34.6" "43.7" "36.8" "28.2" "" "" "" "" "" "" "" "" "" "" "19.2" "13.7" "17.8" "15.4" "18.5" "18.9" "16.1" "19.6" "19.9" "28.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8139955916062878316" "False" "High" "IsMasterProtein" "Q9BZ95" "Histone-lysine N-methyltransferase NSD3 OS=Homo sapiens OX=9606 GN=NSD3 PE=1 SV=1" "0.000" "False" "5.232" "1" "2" "3" "2" "1437" "161.5" "8.21" "4.26" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00855, Pf00856, Pf17907, Pf17982" "54904" "ENSG00000147548" "NSD3" "B7ZL11; D3DSX1; hsa:54904; Q1RMD3; Q3B796; Q6ZSA5; Q9BYU8; Q9BYU9; Q9BZ95; Q9H2M8; Q9H9W9; Q9NXA6" "" "PKMTs methylate histone lysines" "1" "0" "1.136" "1.450" "1.032" "1.741" "1.075" "1.053" "1.043" "1.329" "4.021" "17.2" "19.6" "25.0" "17.8" "30.0" "18.5" "18.1" "18.0" "22.9" "69.2" "" "" "" "" "" "" "" "" "" "" "10.3" "10.2" "13.8" "8.3" "13.9" "9.5" "8.4" "8.1" "12.4" "69.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-344337871911847900" "False" "High" "IsMasterProtein" "Q86X53" "Glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=ERICH1 PE=1 SV=1" "0.000" "False" "5.228" "4" "1" "1" "1" "443" "49.0" "4.78" "4.05" "1" "" "" "" "" "157697" "ENSG00000104714" "ERICH1" "A8K2J9; hsa:157697; Q86X53; Q9P063" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3997402182379015815" "False" "High" "IsMasterProtein" "O15371" "Eukaryotic translation initiation factor 3 subunit D OS=Homo sapiens OX=9606 GN=EIF3D PE=1 SV=1" "0.000" "False" "5.206" "3" "2" "2" "2" "548" "63.9" "6.05" "5.91" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf05091" "8664" "ENSG00000100353" "EIF3D" "A8MWD3; B2R7D4; B4DTF8; B4DVY1; hsa:8664; O15371; Q3MJD9; Q5M9Q6" "Translation factors; VEGFA-VEGFR2 signaling; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1008427851520544832" "False" "High" "IsMasterProtein" "Q4KMP7" "TBC1 domain family member 10B OS=Homo sapiens OX=9606 GN=TBC1D10B PE=1 SV=3" "0.000" "False" "5.200" "5" "2" "3" "2" "808" "87.1" "9.19" "0.00" "2" "transport;other biological processes" "plasma membrane;other membranes;cytosol" "enzyme regulator activity" "Pf00566" "26000" "ENSG00000169221" "TBC1D10B" "B9A6L0; hsa:26000; Q4KMP7; Q6IN54; Q6P530; Q71RG7; Q86VC5; Q9H8Z2; Q9NUN6; Q9UFP2" "" "TBC/RABGAPs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5875685193594640149" "False" "High" "IsMasterProtein" "Q7Z3U7" "Protein MON2 homolog OS=Homo sapiens OX=9606 GN=MON2 PE=1 SV=3" "0.000" "False" "5.190" "1" "2" "2" "2" "1717" "190.2" "6.06" "2.34" "2" "transport" "other membranes;cytosol;other cytoplasmic organelle" "" "Pf09324, Pf12783, Pf16206, Pf16213" "23041" "ENSG00000061987" "MON2" "A5D8U7; A7E2Y0; B9EGP5; F8VWA6; F8W1Z6; hsa:23041; Q7Z3U7; Q86TA2; Q8N3I5; Q8NAI0; Q8NHE2; Q9UPW1" "" "" "0" "0" "0.990" "0.852" "0.785" "1.018" "1.275" "1.098" "0.536" "0.551" "2.027" "26.1" "25.8" "22.2" "20.4" "26.5" "33.2" "28.6" "14.0" "14.3" "52.8" "" "" "" "" "" "" "" "" "" "" "15.6" "13.4" "12.3" "9.6" "12.3" "17.0" "13.3" "6.3" "7.8" "52.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5664998384620828706" "False" "High" "IsMasterProtein" "Q13895" "Bystin OS=Homo sapiens OX=9606 GN=BYSL PE=1 SV=3" "0.000" "False" "5.185" "5" "2" "2" "2" "437" "49.6" "8.12" "2.03" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05291" "705" "ENSG00000112578" "BYSL" "hsa:705; Q13895; Q6P5W4; Q86W44; Q96IP8" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1964659957025433859" "False" "High" "IsMasterProtein" "Q9H2H8" "Peptidyl-prolyl cis-trans isomerase-like 3 OS=Homo sapiens OX=9606 GN=PPIL3 PE=1 SV=1" "0.000" "False" "5.178" "11" "2" "2" "2" "161" "18.1" "6.79" "5.74" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00160" "53938" "ENSG00000240344" "PPIL3" "hsa:53938; Q86WF9; Q96IA9; Q9BXZ1; Q9H2H8" "" "mRNA Splicing - Major Pathway" "1" "0" "0.992" "1.138" "1.030" "1.204" "1.006" "1.157" "0.923" "1.176" "2.007" "223.0" "221.2" "253.8" "229.6" "268.5" "224.4" "258.0" "205.8" "262.3" "447.6" "" "" "" "" "" "" "" "" "" "" "133.5" "114.9" "140.5" "107.8" "124.4" "114.9" "120.0" "92.4" "142.3" "447.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-485685737815851415" "False" "High" "IsMasterProtein" "Q6EMK4" "Vasorin OS=Homo sapiens OX=9606 GN=VASN PE=1 SV=1" "0.000" "False" "5.178" "2" "1" "1" "1" "673" "71.7" "7.39" "3.53" "1" "stress response;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf00008, Pf13855" "114990" "ENSG00000168140; ENSG00000274334" "VASN" "hsa:114990; Q6EMK4; Q6UXL4; Q6UXL5; Q96CX1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1844756928667547842" "False" "High" "IsMasterProtein" "Q9NWU1" "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial OS=Homo sapiens OX=9606 GN=OXSM PE=1 SV=1" "0.000" "False" "5.176" "3" "1" "1" "1" "459" "48.8" "7.66" "2.95" "1" "other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00109, Pf02801" "54995" "ENSG00000151093" "OXSM" "Q9NWU1" "Mitochondrial fatty acid synthesis pathway" "Mitochondrial protein degradation" "2" "0" "0.914" "0.949" "0.985" "0.923" "0.904" "0.811" "0.647" "0.751" "0.626" "33.2" "30.3" "31.5" "32.7" "30.6" "30.0" "26.9" "21.5" "24.9" "20.8" "" "" "" "" "" "" "" "" "" "" "19.9" "15.8" "17.4" "15.3" "14.2" "15.3" "12.5" "9.6" "13.5" "20.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8752239950939414056" "False" "High" "IsMasterProtein" "P18754" "Regulator of chromosome condensation OS=Homo sapiens OX=9606 GN=RCC1 PE=1 SV=1" "0.000" "False" "5.174" "3" "1" "1" "1" "421" "44.9" "7.52" "3.56" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00415" "1104" "ENSG00000180198" "RCC1" "hsa:1104; P18754; Q16269; Q6NT97" "22q11.2 copy number variation syndrome" "Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation" "4" "0" "1.418" "1.161" "1.357" "1.104" "1.295" "1.216" "0.010" "1.158" "10.967" "22.2" "31.5" "25.8" "30.2" "24.5" "28.8" "27.0" "0.0" "25.7" "243.8" "" "" "" "" "" "" "" "" "" "" "13.3" "16.4" "14.3" "14.2" "11.4" "14.7" "12.6" "0.0" "14.0" "243.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "Not Found" "High" "High" "1" "" "908398624639479548" "False" "High" "IsMasterProtein" "P62913" "Large ribosomal subunit protein uL5 OS=Homo sapiens OX=9606 GN=RPL11 PE=1 SV=2" "0.000" "False" "5.163" "10" "2" "2" "2" "178" "20.2" "9.60" "2.39" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00281, Pf00673" "6135" "ENSG00000142676" "RPL11" "hsa:6135; P25121; P39026; P62913; Q8TDH2; Q9Y674" "MET in type 1 papillary renal cell carcinoma; Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Response of EIF2AK4 (GCN2) to amino acid deficiency; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3431130476793294573" "False" "High" "IsMasterProtein" "Q8IUR0" "Trafficking protein particle complex subunit 5 OS=Homo sapiens OX=9606 GN=TRAPPC5 PE=1 SV=1" "0.000" "False" "5.150" "9" "2" "2" "2" "188" "20.8" "9.66" "4.38" "2" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "126003" "ENSG00000181029" "TRAPPC5" "A8K7I6; hsa:126003; Q8IUR0" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7666744292030772641" "False" "High" "IsMasterProtein" "Q9BRK5" "45 kDa calcium-binding protein OS=Homo sapiens OX=9606 GN=SDF4 PE=1 SV=1" "0.000" "False" "5.138" "3" "1" "1" "1" "362" "41.8" "4.86" "3.70" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13202, Pf13499" "51150" "" "SDF4" "B1AME5; B1AME6; B2RDF1; B4DSM1; hsa:51150; Q53G52; Q53HQ9; Q8NBQ3; Q96AA1; Q9BRK5; Q9NZP7; Q9UN53" "" "" "0" "0" "0.918" "0.790" "0.830" "1.083" "0.860" "0.973" "0.889" "1.072" "1.463" "46.3" "42.5" "36.6" "38.4" "50.2" "39.8" "45.1" "41.2" "49.7" "67.8" "" "" "" "" "" "" "" "" "" "" "27.7" "22.1" "20.3" "18.0" "23.3" "20.4" "21.0" "18.5" "26.9" "67.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3538094465215650253" "False" "High" "IsMasterProtein" "Q8N4J0" "Carnosine N-methyltransferase OS=Homo sapiens OX=9606 GN=CARNMT1 PE=1 SV=1" "0.000" "False" "5.137" "5" "2" "5" "2" "409" "47.2" "6.32" "11.63" "2" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf07942" "138199" "ENSG00000156017" "CARNMT1" "hsa:138199; Q7Z383; Q8N4J0; Q8N7C5" "" "Histidine catabolism" "1" "0" "1.133" "1.324" "1.317" "1.420" "1.378" "1.250" "1.290" "1.115" "1.052" "89.0" "100.8" "117.8" "117.1" "126.3" "122.6" "111.2" "114.8" "99.2" "93.6" "" "" "" "" "" "" "" "" "" "" "53.2" "52.4" "65.2" "55.0" "58.5" "62.8" "51.7" "51.5" "53.8" "93.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6209477172492729631" "False" "High" "IsMasterProtein" "Q9UPN6" "SR-related and CTD-associated factor 8 OS=Homo sapiens OX=9606 GN=SCAF8 PE=1 SV=1" "0.000" "False" "5.136" "2" "2" "2" "2" "1271" "140.4" "8.29" "2.09" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf04818" "22828" "ENSG00000213079" "SCAF8" "B7Z888; hsa:22828; Q5TBU6; Q6NSK3; Q9BQN8; Q9BX43; Q9UPN6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9116145290149312693" "False" "High" "IsMasterProtein" "P42226" "Signal transducer and activator of transcription 6 OS=Homo sapiens OX=9606 GN=STAT6 PE=1 SV=1" "0.000" "False" "5.135" "2" "2" "3" "2" "847" "94.1" "6.23" "5.30" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf14596, Pf21354" "6778" "ENSG00000166888" "STAT6" "A8K316; B7ZA27; F5GXI9; hsa:6778; P42226; Q5FBW5; Q71UP4" "Thymic stromal lymphopoietin (TSLP) signaling pathway; Adipogenesis; VEGFA-VEGFR2 signaling; IL-4 signaling pathway; PDGFR-beta pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Neuroinflammation and glutamatergic signaling; Th17 cell differentiation pathway; Inflammatory bowel disease signaling; IL-19 signaling pathway" "Downstream signal transduction; Interleukin-4 and Interleukin-13 signaling; STAT6-mediated induction of chemokines" "13" "0" "0.621" "1.022" "0.872" "0.736" "0.597" "0.719" "0.218" "1.059" "5.726" "36.6" "22.8" "37.4" "31.9" "26.9" "21.9" "26.3" "8.0" "38.8" "209.7" "" "" "" "" "" "" "" "" "" "" "21.9" "11.8" "20.7" "15.0" "12.5" "11.2" "12.2" "3.6" "21.0" "209.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "587629030482776779" "False" "High" "IsMasterProtein" "Q5VZM2" "Ras-related GTP-binding protein B OS=Homo sapiens OX=9606 GN=RRAGB PE=1 SV=1" "0.000" "False" "5.124" "6" "2" "2" "2" "374" "43.2" "6.21" "4.12" "2" "stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04670" "10325" "ENSG00000083750" "RRAGB" "A8K042; hsa:10325; Q15348; Q5VZM2; Q8N3T0" "Target of rapamycin signaling; 2q37 copy number variation syndrome" "Macroautophagy; TP53 Regulates Metabolic Genes; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; Energy dependent regulation of mTOR by LKB1-AMPK" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1176718520801112015" "False" "High" "IsMasterProtein" "P11441" "Ubiquitin-like protein 4A OS=Homo sapiens OX=9606 GN=UBL4A PE=1 SV=1" "0.000" "False" "5.119" "11" "2" "2" "2" "157" "17.8" "8.66" "4.99" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf17840" "8266" "ENSG00000102178" "UBL4A" "hsa:8266; P11441; Q5HY80" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "1.077" "0.999" "1.102" "1.273" "1.169" "1.220" "0.889" "0.994" "1.658" "64.9" "69.9" "64.9" "71.5" "82.6" "75.9" "79.2" "57.7" "64.6" "107.6" "" "" "" "" "" "" "" "" "" "" "38.9" "36.3" "35.9" "33.6" "38.3" "38.9" "36.8" "25.9" "35.0" "107.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625848183831329232" "False" "High" "IsMasterProtein" "Q6VMQ6" "Activating transcription factor 7-interacting protein 1 OS=Homo sapiens OX=9606 GN=ATF7IP PE=1 SV=3" "0.000" "False" "5.106" "1" "2" "2" "2" "1270" "136.3" "4.70" "2.28" "2" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf16788, Pf16794" "55729" "ENSG00000171681" "ATF7IP" "F5GX74; G3V1U0; hsa:55729; Q4G0T9; Q6P3T3; Q6VMQ6; Q86XW5; Q9NVJ9; Q9NWC2; Q9Y4X8" "" "PKMTs methylate histone lysines" "1" "0" "0.972" "1.250" "1.184" "1.046" "0.986" "1.122" "0.715" "1.053" "3.293" "70.8" "68.9" "88.6" "83.9" "74.1" "69.9" "79.5" "50.7" "74.6" "233.3" "" "" "" "" "" "" "" "" "" "" "42.4" "35.8" "49.0" "39.4" "34.4" "35.8" "37.0" "22.7" "40.5" "233.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5779519367271372583" "False" "High" "IsMasterProtein" "Q15645" "Pachytene checkpoint protein 2 homolog OS=Homo sapiens OX=9606 GN=TRIP13 PE=1 SV=2" "0.000" "False" "5.106" "4" "2" "2" "2" "432" "48.5" "6.09" "5.16" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00004" "9319" "ENSG00000071539" "TRIP13" "C9K0T3; D3DTC0; hsa:9319; O15324; Q15645" "Male infertility" "" "1" "0" "0.959" "0.738" "0.964" "0.799" "0.868" "1.113" "0.996" "0.789" "2.239" "55.4" "53.1" "40.9" "53.4" "44.3" "48.1" "61.7" "55.2" "43.7" "124.1" "" "" "" "" "" "" "" "" "" "" "33.2" "27.6" "22.6" "25.1" "20.5" "24.6" "28.7" "24.8" "23.7" "124.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6991992927110115551" "False" "High" "IsMasterProtein" "Q99504" "Eyes absent homolog 3 OS=Homo sapiens OX=9606 GN=EYA3 PE=1 SV=3" "0.000" "False" "5.099" "6" "3" "3" "3" "573" "62.6" "5.21" "4.07" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00702" "2140" "ENSG00000158161" "EYA3" "A8K190; B4DIR7; B4DNZ7; hsa:2140; O95463; Q8IVX7; Q99504; Q99813" "" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3102131592095934236" "False" "High" "IsMasterProtein" "Q969G6" "Riboflavin kinase OS=Homo sapiens OX=9606 GN=RFK PE=1 SV=2" "0.000" "False" "5.097" "12" "2" "2" "2" "155" "17.6" "8.13" "6.25" "2" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf01687" "55312" "ENSG00000135002" "RFK" "hsa:55312; Q5JSG9; Q969G6; Q9NUT7" "Selenium micronutrient network; Folate metabolism; TNF-alpha signaling pathway" "Vitamin B2 (riboflavin) metabolism" "4" "0" "1.026" "0.973" "1.130" "0.979" "1.180" "1.058" "1.141" "0.957" "0.702" "203.8" "209.0" "198.2" "230.3" "199.5" "240.5" "215.7" "232.4" "195.1" "143.2" "" "" "" "" "" "" "" "" "" "" "122.0" "108.6" "109.8" "108.1" "92.5" "123.1" "100.3" "104.4" "105.8" "143.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2602489287625283403" "False" "High" "IsMasterProtein" "P62330" "ADP-ribosylation factor 6 OS=Homo sapiens OX=9606 GN=ARF6 PE=1 SV=2" "0.000" "False" "5.093" "6" "1" "2" "1" "175" "20.1" "8.95" "3.91" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00025" "382" "ENSG00000165527" "ARF6" "hsa:382; P26438; P62330; Q6FGZ2" "VEGFA-VEGFR2 signaling; Ras signaling; EGF/EGFR signaling pathway; IL-18 signaling pathway; Insulin signaling; CCL18 signaling pathway; 2q13 copy number variation syndrome" "Clathrin-mediated endocytosis; TBC/RABGAPs; MET receptor recycling" "10" "0" "1.074" "0.980" "0.845" "1.090" "0.978" "1.233" "1.189" "1.350" "0.835" "22.4" "24.1" "22.0" "19.0" "24.4" "21.9" "27.7" "26.7" "30.3" "18.7" "" "" "" "" "" "" "" "" "" "" "13.4" "12.5" "12.2" "8.9" "11.3" "11.2" "12.9" "12.0" "16.4" "18.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3530888468156294697" "False" "High" "IsMasterProtein" "O00541" "Pescadillo homolog OS=Homo sapiens OX=9606 GN=PES1 PE=1 SV=1" "0.000" "False" "5.087" "4" "3" "3" "3" "588" "68.0" "7.33" "6.23" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06732, Pf16589" "23481" "ENSG00000100029" "PES1" "hsa:23481; O00541; Q6IC29" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.069" "1.012" "1.183" "1.248" "1.201" "1.152" "0.841" "1.180" "3.982" "57.2" "61.2" "57.9" "67.7" "71.4" "68.7" "65.9" "48.1" "67.5" "227.8" "" "" "" "" "" "" "" "" "" "" "34.2" "31.8" "32.0" "31.8" "33.1" "35.2" "30.7" "21.6" "36.6" "227.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604147819280005923" "False" "High" "IsMasterProtein" "P50613" "Cyclin-dependent kinase 7 OS=Homo sapiens OX=9606 GN=CDK7 PE=1 SV=1" "0.000" "False" "5.079" "5" "2" "5" "2" "346" "39.0" "8.47" "12.36" "2" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1022" "ENSG00000134058; ENSG00000277273" "CDK7" "hsa:1022; P50613; Q9BS60; Q9UE19" "MicroRNAs in cardiomyocyte hypertrophy; Cell cycle; Cardiac hypertrophic response; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum" "RNA polymerase II transcribes snRNA genes; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "43" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2382558777454412534" "False" "High" "IsMasterProtein" "P25686" "DnaJ homolog subfamily B member 2 OS=Homo sapiens OX=9606 GN=DNAJB2 PE=1 SV=3" "0.000" "False" "5.073" "6" "2" "2" "2" "324" "35.6" "5.95" "2.55" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00226" "3300" "ENSG00000135924" "DNAJB2" "A8K9P6; hsa:3300; P25686; Q53QD7; Q8IUK1; Q8IUK2; Q96F52" "" "" "0" "0" "0.836" "0.844" "0.847" "1.174" "0.864" "1.183" "0.711" "1.058" "1.910" "33.0" "27.6" "27.8" "27.9" "38.7" "28.5" "39.1" "23.4" "34.9" "63.0" "" "" "" "" "" "" "" "" "" "" "19.7" "14.3" "15.4" "13.1" "18.0" "14.6" "18.2" "10.5" "18.9" "63.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3857525489381916364" "False" "High" "IsMasterProtein" "A8MXV4" "Acyl-coenzyme A diphosphatase NUDT19 OS=Homo sapiens OX=9606 GN=NUDT19 PE=1 SV=1" "0.000" "False" "5.066" "6" "2" "2" "2" "375" "42.2" "7.64" "4.92" "2" "other metabolic processes" "cytosol;other cytoplasmic organelle" "other molecular function" "" "390916" "ENSG00000213965" "NUDT19" "A8MXV4; hsa:390916" "" "Peroxisomal lipid metabolism; Peroxisomal protein import" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6975409787188746590" "False" "High" "IsMasterProtein" "Q7L513" "Fc receptor-like A OS=Homo sapiens OX=9606 GN=FCRLA PE=1 SV=2" "0.000" "False" "5.065" "4" "2" "2" "2" "359" "38.9" "5.36" "6.10" "2" "signal transduction;other biological processes" "other cell component" "other molecular function" "Pf13895" "84824" "ENSG00000132185" "FCRLA" "A0N0M1; A6NC03; A6NL20; F5H720; F8W743; G3V1J2; hsa:84824; Q5VXA1; Q5VXA2; Q5VXA3; Q5VXA4; Q5VXB0; Q5VXB1; Q7L513; Q8NEW4; Q8WXH3; Q96PC6; Q96PJ0; Q96PJ1; Q96PJ2; Q96PJ4; Q9BR57" "" "" "0" "0" "0.981" "1.228" "1.046" "1.112" "1.029" "0.988" "0.667" "1.111" "3.366" "166.9" "163.8" "204.9" "174.5" "185.6" "171.7" "164.8" "111.4" "185.5" "561.8" "" "" "" "" "" "" "" "" "" "" "99.9" "85.1" "113.5" "81.9" "86.0" "87.9" "76.6" "50.0" "100.6" "561.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-708383096801431027" "False" "High" "IsMasterProtein" "Q9HD34" "LYR motif-containing protein 4 OS=Homo sapiens OX=9606 GN=LYRM4 PE=1 SV=1" "0.000" "False" "5.063" "22" "2" "6" "2" "91" "10.8" "10.73" "11.23" "2" "cell organization and biogenesis" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf05347" "57128" "ENSG00000214113" "LYRM4" "A8K543; hsa:57128; Q5XKP1; Q9HD34" "Iron-sulfur cluster biogenesis" "Mitochondrial iron-sulfur cluster biogenesis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5853825877774435955" "False" "High" "IsMasterProtein" "Q96HQ2" "CDKN2AIP N-terminal-like protein OS=Homo sapiens OX=9606 GN=CDKN2AIPNL PE=1 SV=1" "0.000" "False" "5.050" "9" "1" "1" "1" "116" "13.2" "5.00" "4.10" "1" "" "" "" "Pf11952" "91368" "ENSG00000237190" "CDKN2AIPNL" "hsa:91368; Q8WVE3; Q96HQ2" "" "" "0" "0" "1.086" "1.064" "1.322" "1.168" "1.089" "1.104" "1.350" "1.320" "0.686" "94.1" "102.2" "100.2" "124.5" "109.9" "102.5" "103.9" "127.0" "124.2" "64.6" "" "" "" "" "" "" "" "" "" "" "56.3" "53.1" "55.5" "58.4" "50.9" "52.5" "48.3" "57.0" "67.4" "64.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3087577180827751856" "False" "High" "IsMasterProtein" "Q15172" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R5A PE=1 SV=1" "0.000" "False" "5.047" "3" "2" "2" "1" "486" "56.2" "6.71" "5.21" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01603" "5525" "ENSG00000066027" "PPP2R5A" "B2R6D2; B7Z7L2; D3DT99; hsa:5525; Q15172; Q2NL72; Q5VVB2; Q8TBI9" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "PKR-mediated signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF activation; Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling" "27" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7441376780111574138" "False" "High" "IsMasterProtein" "Q96BS2" "Calcineurin B homologous protein 3 OS=Homo sapiens OX=9606 GN=TESC PE=1 SV=3" "0.000" "False" "5.043" "11" "2" "2" "2" "214" "24.7" "4.93" "4.76" "2" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13405" "54997" "ENSG00000088992" "TESC" "F5H1Y5; hsa:54997; Q96BS2; Q9NWT9" "" "" "0" "0" "1.709" "1.832" "2.401" "1.601" "2.256" "2.305" "1.070" "1.531" "2.490" "14.9" "25.4" "27.2" "35.7" "23.8" "33.5" "34.2" "15.9" "22.7" "37.0" "" "" "" "" "" "" "" "" "" "" "8.9" "13.2" "15.1" "16.7" "11.0" "17.2" "15.9" "7.1" "12.3" "37.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3338411764392514561" "False" "High" "IsMasterProtein" "P45954" "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADSB PE=1 SV=1" "0.000" "False" "5.037" "3" "1" "2" "1" "432" "47.5" "6.99" "4.39" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "36" "ENSG00000196177" "ACADSB" "B4DQ51; hsa:36; P45954; Q5SQN6; Q96CX7" "Valproic acid pathway" "Mitochondrial protein degradation; Branched-chain amino acid catabolism" "3" "0" "1.013" "1.141" "1.058" "1.199" "1.549" "1.646" "1.099" "1.183" "1.420" "44.2" "44.8" "50.4" "46.8" "53.0" "68.5" "72.8" "48.6" "52.3" "62.8" "" "" "" "" "" "" "" "" "" "" "26.5" "23.3" "27.9" "22.0" "24.6" "35.1" "33.8" "21.8" "28.4" "62.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8712581138028706155" "False" "High" "IsMasterProtein" "Cont_P02081" "Hemoglobin fetal subunit beta OS=Bos taurus OX=9913 PE=1 SV=1" "0.000" "True" "5.026" "8" "1" "1" "1" "145" "15.8" "7.03" "3.67" "1" "other metabolic processes;transport;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00042" "104983812; 109569915; 109569938; 511735" "ENSBIXG00000000751; ENSBTAG00000038748" "LOC104983812; LOC109569915; LOC113905586" "A0A4W2CHH0; A0A6P3GXP4; A0A6P5D2L1; bbis:104983812; biu:109569915; biu:109569938; bta:511735; P02081; Q3SX09" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-994823259514569156" "False" "High" "IsMasterProtein" "Q96I59" "Asparaginyl-tRNA synthetase OS=Homo sapiens OX=9606 GN=NARS2 PE=1 SV=3" "0.000" "False" "5.025" "3" "2" "2" "2" "477" "54.1" "7.24" "5.16" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336" "79731" "ENSG00000137513" "NARS2" "G3V178; hsa:79731; Q96I59" "Ectoderm differentiation" "Mitochondrial tRNA aminoacylation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5219195248541824635" "False" "High" "IsMasterProtein" "Q92609" "TBC1 domain family member 5 OS=Homo sapiens OX=9606 GN=TBC1D5 PE=1 SV=1" "0.000" "False" "5.021" "3" "2" "3" "2" "795" "88.9" "6.54" "1.76" "2" "other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00566" "9779" "ENSG00000131374" "TBC1D5" "A6NP25; C9JP52; hsa:9779; Q92609" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4686593457953999194" "False" "High" "IsMasterProtein" "P45985" "Dual specificity mitogen-activated protein kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP2K4 PE=1 SV=1" "0.000" "False" "5.018" "7" "2" "2" "2" "399" "44.3" "8.07" "4.71" "2" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6416" "ENSG00000065559" "MAP2K4" "B2R7N7; B3KYB2; D3DTS5; hsa:6416; P45985; Q5U0B8; Q6FHX4; Q6P9H2; Q6PIE6" "MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; Glioblastoma signaling pathways; TNF-alpha signaling pathway; PDGF pathway; Apoptosis; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Fas ligand pathway and stress induction of heat shock proteins; Photodynamic therapy-induced AP-1 survival signaling; IL6 signaling pathway; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Oxidative damage response; PDGFR-beta pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; GNAQ pathways in port-wine stain; ErbB signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Uptake and function of anthrax toxins; MAP3K8 (TPL2)-dependent MAPK1/3 activation" "35" "0" "0.996" "0.913" "1.055" "1.284" "1.183" "0.788" "1.112" "1.079" "1.339" "17.7" "17.6" "16.1" "18.6" "22.7" "20.9" "13.9" "19.6" "19.1" "23.6" "" "" "" "" "" "" "" "" "" "" "10.6" "9.1" "8.9" "8.7" "10.5" "10.7" "6.5" "8.8" "10.3" "23.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "262985657933925195" "False" "High" "IsMasterProtein" "Q969H6" "Ribonuclease P/MRP protein subunit POP5 OS=Homo sapiens OX=9606 GN=POP5 PE=1 SV=1" "0.000" "False" "5.003" "16" "2" "3" "2" "163" "18.8" "7.27" "5.23" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01900" "51367" "ENSG00000167272" "POP5" "A6NL80; hsa:51367; Q53FS5; Q969H6; Q9Y2Q6" "" "tRNA processing in the nucleus" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4323933511445947970" "False" "High" "IsMasterProtein" "P43405" "Tyrosine-protein kinase SYK OS=Homo sapiens OX=9606 GN=SYK PE=1 SV=1" "0.000" "False" "4.993" "3" "2" "2" "2" "635" "72.0" "8.25" "6.23" "2" "cell adhesion;cell-cell signaling;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00017, Pf07714" "6850" "ENSG00000165025" "SYK" "hsa:6850; P43405" "IL-5 signaling pathway; RANKL/RANK signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Microglia pathogen phagocytosis pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; IL-2 signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "Integrin signaling; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; CLEC7A (Dectin-1) signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; DAP12 signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Interleukin-2 signaling; Dectin-2 family; FLT3 signaling through SRC family kinases" "30" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "721169718826189063" "False" "High" "IsMasterProtein" "Q8IX12" "Cell division cycle and apoptosis regulator protein 1 OS=Homo sapiens OX=9606 GN=CCAR1 PE=1 SV=2" "0.000" "False" "4.990" "1" "2" "4" "2" "1150" "132.7" "5.76" "5.46" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf14443, Pf14444, Pf19256, Pf19257" "55749" "ENSG00000060339" "CCAR1" "A0JLT7; A1L4P7; A8K9D4; B4DNP8; B4DRK8; hsa:55749; Q32NE3; Q5EBM3; Q5VUP6; Q6PIZ0; Q6X935; Q8IX12; Q9H8N4; Q9NVA7; Q9NVQ0; Q9NWM6" "" "mRNA Splicing - Major Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7170816328475154252" "False" "High" "IsMasterProtein" "Cont_Q2KJF1" "Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1" "0.000" "True" "4.988" "4" "2" "2" "2" "503" "53.5" "5.43" "3.14" "2" "" "non-structural extracellular;plasma membrane;other membranes" "" "Pf00047" "518955" "ENSBTAG00000009735" "A1BG" "bta:518955; Q2KJF1" "" "Neutrophil degranulation; Platelet degranulation" "2" "0" "1.321" "0.919" "1.311" "0.770" "1.055" "1.105" "1.179" "1.334" "0.638" "74.1" "97.8" "68.1" "97.1" "57.0" "78.1" "81.9" "87.3" "98.8" "47.2" "" "" "" "" "" "" "" "" "" "" "44.3" "50.8" "37.7" "45.6" "26.4" "40.0" "38.1" "39.2" "53.6" "47.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6951101032549152638" "False" "High" "IsMasterProtein" "Q9BYD3" "Large ribosomal subunit protein uL4m OS=Homo sapiens OX=9606 GN=MRPL4 PE=1 SV=1" "0.000" "False" "4.986" "6" "1" "2" "1" "311" "34.9" "9.72" "7.91" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00573" "51073" "ENSG00000105364" "MRPL4" "A6NNV7; hsa:51073; Q9BW07; Q9BYD3; Q9H4N2; Q9Y317" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4516330367870273472" "False" "High" "IsMasterProtein" "P09086" "POU domain, class 2, transcription factor 2 OS=Homo sapiens OX=9606 GN=POU2F2 PE=1 SV=3" "0.000" "False" "4.969" "5" "2" "2" "2" "479" "51.2" "8.43" "2.78" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00157" "5452" "ENSG00000028277" "POU2F2" "hsa:5452; P09086; Q16648; Q7M4M8; Q9BRS4" "Ectoderm differentiation; Prion disease pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "RNA polymerase II transcribes snRNA genes" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6317068778034787864" "False" "High" "IsMasterProtein" "Q9BTE3" "Mini-chromosome maintenance complex-binding protein OS=Homo sapiens OX=9606 GN=MCMBP PE=1 SV=2" "0.000" "False" "4.967" "3" "2" "3" "2" "642" "72.9" "5.87" "4.60" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09739" "79892" "ENSG00000197771" "MCMBP" "B3KSP7; hsa:79892; Q6IA56; Q9BTE3; Q9BVT9; Q9H916" "" "" "0" "0" "1.004" "1.095" "1.164" "0.990" "1.308" "0.992" "0.775" "0.953" "3.835" "67.1" "67.3" "73.4" "78.1" "66.4" "87.7" "66.6" "52.0" "63.9" "257.3" "" "" "" "" "" "" "" "" "" "" "40.1" "35.0" "40.7" "36.6" "30.8" "44.9" "30.9" "23.3" "34.7" "257.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1068600970013118283" "False" "High" "IsMasterProtein" "Q99584" "Protein S100-A13 OS=Homo sapiens OX=9606 GN=S100A13 PE=1 SV=1" "0.000" "False" "4.966" "15" "2" "4" "2" "98" "11.5" "6.16" "7.24" "2" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01023" "6284" "ENSG00000189171" "S100A13" "hsa:6284; Q52PI9; Q6FGF8; Q99584" "" "" "0" "0" "1.179" "1.154" "1.245" "1.367" "1.085" "1.063" "1.089" "1.331" "1.135" "83.1" "98.0" "95.9" "103.5" "113.6" "90.1" "88.3" "90.5" "110.6" "94.3" "" "" "" "" "" "" "" "" "" "" "49.7" "50.9" "53.1" "48.6" "52.7" "46.1" "41.1" "40.6" "60.0" "94.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4174205388023222362" "False" "High" "IsMasterProtein" "Q96H20" "Vacuolar-sorting protein SNF8 OS=Homo sapiens OX=9606 GN=SNF8 PE=1 SV=1" "0.000" "False" "4.962" "8" "2" "2" "2" "258" "28.8" "6.65" "2.34" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04157" "11267" "ENSG00000159210" "SNF8" "hsa:11267; Q8IXY3; Q96H20; Q9UN50" "" "HCMV Late Events; Endosomal Sorting Complex Required For Transport (ESCRT)" "2" "0" "1.126" "1.047" "1.393" "1.269" "1.040" "1.527" "1.250" "1.207" "1.496" "55.6" "62.6" "58.2" "77.4" "70.5" "57.8" "84.9" "69.5" "67.1" "83.2" "" "" "" "" "" "" "" "" "" "" "33.3" "32.5" "32.2" "36.4" "32.7" "29.6" "39.5" "31.2" "36.4" "83.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5310524526174993710" "False" "High" "IsMasterProtein" "P51003" "Poly(A) polymerase alpha OS=Homo sapiens OX=9606 GN=PAPOLA PE=1 SV=4" "0.000" "False" "4.958" "4" "2" "2" "1" "745" "82.8" "7.37" "2.24" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04926, Pf04928, Pf20750" "10914" "ENSG00000090060" "PAPOLA" "hsa:10914; P51003; Q86SX4; Q86TV0; Q8IYF5; Q9BVU2" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "Not Found" "High" "High" "High" "Not Found" "High" "High" "1" "" "4404494894943398685" "False" "High" "IsMasterProtein" "Q6P5R6" "Ribosomal protein eL22-like OS=Homo sapiens OX=9606 GN=RPL22L1 PE=1 SV=2" "0.000" "False" "4.935" "18" "2" "2" "2" "122" "14.6" "9.38" "4.56" "2" "protein metabolism;other metabolic processes" "translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01776" "200916" "ENSG00000163584" "RPL22L1" "hsa:200916; Q32Q77; Q6P5R6" "" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "13" "0" "0.978" "0.936" "1.109" "0.912" "1.010" "1.015" "1.030" "1.029" "2.452" "184.6" "180.6" "172.8" "204.7" "168.4" "186.5" "187.4" "190.1" "189.9" "452.7" "" "" "" "" "" "" "" "" "" "" "110.5" "93.8" "95.7" "96.1" "78.1" "95.5" "87.1" "85.4" "103.0" "452.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6821659264702231707" "False" "High" "IsMasterProtein" "P13284" "Gamma-interferon-inducible lysosomal thiol reductase OS=Homo sapiens OX=9606 GN=IFI30 PE=1 SV=3" "0.000" "False" "4.932" "8" "2" "8" "2" "250" "27.9" "4.88" "0.00" "2" "other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03227" "10437" "ENSG00000216490" "IFI30" "hsa:10437; P13284; Q76MF9; Q8NEI4; Q8WU77; Q9UL08" "" "MHC class II antigen presentation; Interferon gamma signaling" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8831328934271129534" "False" "High" "IsMasterProtein" "Q92733" "Proline-rich protein PRCC OS=Homo sapiens OX=9606 GN=PRCC PE=1 SV=1" "0.000" "False" "4.913" "4" "2" "4" "2" "491" "52.4" "5.10" "8.07" "2" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf10253" "5546" "ENSG00000143294" "PRCC" "A8K1F7; hsa:5546; O00665; O00724; Q5SZ06; Q92733" "MET in type 1 papillary renal cell carcinoma; Type 2 papillary renal cell carcinoma; IL-18 signaling pathway" "mRNA Splicing - Major Pathway" "4" "0" "0.898" "1.005" "0.885" "1.012" "0.970" "0.917" "0.925" "0.963" "0.683" "231.6" "207.9" "232.8" "205.0" "234.5" "224.7" "212.5" "214.3" "223.1" "158.3" "" "" "" "" "" "" "" "" "" "" "138.6" "108.1" "128.9" "96.3" "108.7" "115.0" "98.8" "96.2" "121.0" "158.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7486166187731566186" "False" "High" "IsMasterProtein" "Q9BV57" "Acireductone dioxygenase OS=Homo sapiens OX=9606 GN=ADI1 PE=1 SV=1" "0.000" "False" "4.908" "12" "2" "2" "2" "179" "21.5" "5.68" "3.60" "2" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03079" "55256" "ENSG00000182551" "ADI1" "D6W4Y3; hsa:55256; Q53HW3; Q53QD3; Q57YV7; Q68CK2; Q6ZSF7; Q7Z512; Q96P85; Q9BV57; Q9NV57" "Methionine de novo and salvage pathway" "Methionine salvage pathway" "2" "0" "1.104" "1.436" "0.992" "1.328" "1.383" "1.130" "0.648" "1.227" "6.027" "71.2" "78.6" "102.3" "70.6" "94.5" "98.5" "80.4" "46.1" "87.3" "429.1" "" "" "" "" "" "" "" "" "" "" "42.6" "40.9" "56.6" "33.1" "43.8" "50.4" "37.4" "20.7" "47.4" "429.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5259121706082363690" "False" "High" "IsMasterProtein" "Q6NS38" "DNA oxidative demethylase ALKBH2 OS=Homo sapiens OX=9606 GN=ALKBH2 PE=1 SV=1" "0.000" "False" "4.906" "7" "1" "1" "1" "261" "29.3" "9.66" "3.48" "1" "DNA metabolism;other metabolic processes;stress response" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13532" "121642" "ENSG00000189046" "ALKBH2" "A4PET2; hsa:121642; Q5XLE3; Q6NS38" "Direct reversal repair" "ALKBH2 mediated reversal of alkylation damage" "2" "0" "0.817" "1.220" "0.829" "0.746" "0.582" "1.026" "0.926" "0.746" "0.883" "33.2" "27.1" "40.5" "27.5" "24.8" "19.3" "34.1" "30.7" "24.8" "29.3" "" "" "" "" "" "" "" "" "" "" "19.9" "14.1" "22.4" "12.9" "11.5" "9.9" "15.8" "13.8" "13.4" "29.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4228584982071455131" "False" "High" "IsMasterProtein" "Q92769" "Histone deacetylase 2 OS=Homo sapiens OX=9606 GN=HDAC2 PE=1 SV=2" "0.000" "False" "4.901" "4" "2" "2" "1" "488" "55.3" "5.91" "5.73" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00850" "3066" "ENSG00000196591" "HDAC2" "B3KRS5; B4DL58; E1P561; hsa:3066; Q5SRI8; Q5SZ86; Q8NEH4; Q92769" "Cell cycle; Neural crest differentiation; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Effect of progerin on genes involved in progeria; Ciliary landscape; 7q11.23 copy number variation syndrome; SARS-CoV-2 innate immunity evasion and cell-specific immune response; TAR syndrome; Notch signaling pathway" "Factors involved in megakaryocyte development and platelet production; Regulation of MECP2 expression and activity; Regulation of TP53 Activity through Acetylation; Potential therapeutics for SARS; SUMOylation of chromatin organization proteins; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; STAT3 nuclear events downstream of ALK signaling; EGR2 and SOX10-mediated initiation of Schwann cell myelination; MECP2 regulates neuronal receptors and channels" "30" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5620722506811584939" "False" "High" "IsMasterProtein" "Q96GG9" "DCN1-like protein 1 OS=Homo sapiens OX=9606 GN=DCUN1D1 PE=1 SV=1" "0.000" "False" "4.891" "7" "2" "3" "2" "259" "30.1" "5.34" "7.83" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03556, Pf14555" "54165" "ENSG00000043093" "DCUN1D1" "B2RB37; hsa:54165; Q7L3G9; Q8TEX7; Q96GG9; Q9H6M1; Q9HCT3" "" "Neddylation" "1" "0" "1.071" "1.233" "0.866" "1.112" "1.218" "0.893" "0.894" "1.051" "2.035" "187.9" "201.2" "231.7" "162.7" "209.0" "228.9" "167.9" "167.9" "197.6" "382.3" "" "" "" "" "" "" "" "" "" "" "112.4" "104.6" "128.3" "76.4" "96.9" "117.2" "78.0" "75.4" "107.2" "382.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7740288424381142174" "False" "High" "IsMasterProtein" "O43181" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS4 PE=1 SV=1" "0.000" "False" "4.886" "5" "1" "1" "1" "175" "20.1" "10.30" "3.45" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf04800" "4724" "ENSG00000164258" "NDUFS4" "hsa:4724; O43181; Q9BS69" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4115257495252240726" "False" "High" "IsMasterProtein" "P82909" "Alpha-ketoglutarate dehydrogenase component 4 OS=Homo sapiens OX=9606 GN=KGD4 PE=1 SV=2" "0.000" "False" "4.883" "12" "1" "3" "1" "103" "11.5" "9.99" "7.54" "1" "other metabolic processes" "other membranes;mitochondrion" "" "" "92259" "ENSG00000134056; ENSG00000278461" "KGD4" "hsa:92259; P82909; Q9H2H4" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.100" "0.933" "1.255" "0.930" "1.063" "1.168" "1.080" "0.944" "0.614" "63.7" "70.1" "59.4" "80.0" "59.2" "67.8" "74.4" "68.9" "60.1" "39.1" "" "" "" "" "" "" "" "" "" "" "38.1" "36.4" "32.9" "37.5" "27.5" "34.7" "34.6" "30.9" "32.6" "39.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3800161177308876944" "False" "High" "IsMasterProtein" "Q8NEM2" "SHC SH2 domain-binding protein 1 OS=Homo sapiens OX=9606 GN=SHCBP1 PE=1 SV=3" "0.000" "False" "4.882" "3" "2" "2" "2" "672" "75.6" "4.75" "4.70" "2" "signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf13229" "79801" "ENSG00000171241" "SHCBP1" "hsa:79801; Q8NEM2; Q96N60; Q9BVS0; Q9H6P6" "Genetic causes of porto-sinusoidal vascular disease" "" "1" "0" "0.982" "0.646" "0.506" "1.400" "0.952" "0.625" "0.021" "1.086" "8.970" "14.8" "14.6" "9.6" "7.5" "20.8" "14.1" "9.3" "0.3" "16.1" "133.1" "" "" "" "" "" "" "" "" "" "" "8.9" "7.6" "5.3" "3.5" "9.6" "7.2" "4.3" "0.1" "8.7" "133.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7088025864314276117" "False" "High" "IsMasterProtein" "O95793" "Double-stranded RNA-binding protein Staufen homolog 1 OS=Homo sapiens OX=9606 GN=STAU1 PE=1 SV=2" "0.000" "False" "4.874" "3" "2" "2" "2" "577" "63.1" "9.44" "2.74" "2" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf16482" "6780" "ENSG00000124214" "STAU1" "A8K9Z4; E1P5Y1; E1P608; hsa:6780; O95793; Q5JW29; Q6GTM4; Q9H5B4; Q9H5B5; Q9Y3Q2" "" "" "0" "0" "0.997" "1.186" "0.911" "1.258" "1.016" "0.961" "1.018" "1.201" "1.632" "97.8" "97.5" "115.9" "89.1" "123.0" "99.3" "93.9" "99.6" "117.4" "159.6" "" "" "" "" "" "" "" "" "" "" "58.5" "50.7" "64.2" "41.8" "57.0" "50.8" "43.7" "44.7" "63.7" "159.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5779198879907914861" "False" "High" "IsMasterProtein" "P62328" "Thymosin beta-4 OS=Homo sapiens OX=9606 GN=TMSB4X PE=1 SV=2" "0.000" "True" "4.858" "32" "2" "27" "2" "44" "5.1" "5.06" "70.37" "2" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01290" "7114" "ENSG00000205542" "TMSB4X" "hsa:7114; P01253; P01254; P62328; Q546P5; Q63576; Q9UE55" "Genes targeted by miRNAs in adipocytes; VEGFA-VEGFR2 signaling; IL-18 signaling pathway; Regulation of actin cytoskeleton" "Platelet degranulation" "5" "0" "1.042" "1.132" "1.121" "1.179" "1.207" "1.029" "1.233" "1.032" "0.492" "2477.5" "2580.8" "2803.8" "2778.3" "2921.0" "2989.2" "2550.1" "3055.7" "2556.7" "1218.1" "" "" "" "" "" "" "" "" "" "" "1482.7" "1341.2" "1552.7" "1304.3" "1353.9" "1530.3" "1185.7" "1371.8" "1387.1" "1218.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8443546389451323737" "False" "High" "IsMasterProtein" "Q96HJ9" "Protein FMC1 homolog OS=Homo sapiens OX=9606 GN=FMC1 PE=1 SV=2" "0.000" "False" "4.858" "11" "1" "1" "1" "113" "12.7" "10.07" "2.55" "1" "cell organization and biogenesis;other biological processes" "mitochondrion" "" "Pf13233" "100996928; 154791" "ENSG00000164898" "FMC1" "B7Z4Q3; hsa:100996928; hsa:154791; Q75M90; Q96HJ9; Q9P0B3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7173592296681882204" "False" "High" "IsMasterProtein" "Q15651" "High mobility group nucleosome-binding domain-containing protein 3 OS=Homo sapiens OX=9606 GN=HMGN3 PE=1 SV=2" "0.000" "False" "4.850" "17" "2" "18" "2" "99" "10.7" "9.66" "34.26" "2" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "9324" "ENSG00000118418" "HMGN3" "B2RD37; hsa:9324; Q15651; Q5HYD3; Q7RTT0; Q969M5; Q9BZT7" "" "" "0" "0" "0.996" "1.190" "1.256" "1.232" "1.225" "1.137" "1.317" "1.205" "0.577" "276.9" "275.8" "329.6" "347.7" "341.2" "339.3" "314.8" "364.8" "333.9" "159.9" "" "" "" "" "" "" "" "" "" "" "165.7" "143.3" "182.5" "163.2" "158.2" "173.7" "146.4" "163.8" "181.1" "159.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6627210930524934042" "False" "High" "IsMasterProtein" "Q8TCF1" "AN1-type zinc finger protein 1 OS=Homo sapiens OX=9606 GN=ZFAND1 PE=1 SV=1" "0.000" "False" "4.849" "5" "1" "1" "1" "268" "30.8" "7.39" "4.34" "1" "cell organization and biogenesis;other biological processes" "other cell component" "other molecular function" "Pf01428" "79752" "ENSG00000104231" "ZFAND1" "E5RIG0; E5RJ99; hsa:79752; Q658R7; Q6IA32; Q6PGQ6; Q8TCF1; Q9H810" "" "" "0" "0" "1.262" "1.060" "1.876" "1.741" "1.549" "0.959" "1.013" "1.042" "2.175" "17.2" "21.7" "18.3" "32.3" "30.0" "26.7" "16.5" "17.5" "18.0" "37.5" "" "" "" "" "" "" "" "" "" "" "10.3" "11.3" "10.1" "15.2" "13.9" "13.7" "7.7" "7.8" "9.7" "37.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9100750251972445181" "False" "High" "IsMasterProtein" "Q14C86" "GTPase-activating protein and VPS9 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GAPVD1 PE=1 SV=2" "0.000" "False" "4.848" "1" "1" "2" "1" "1478" "164.9" "5.22" "3.96" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00616, Pf02204, Pf18151" "26130" "ENSG00000165219" "GAPVD1" "A8MYK3; B0QZ62; B0QZ63; B0QZ64; hsa:26130; Q14C76; Q14C86; Q2Q1W1; Q8ND92; Q8WU86; Q96CZ4; Q9NXQ1; Q9P207; Q9Y4N0" "" "RAB GEFs exchange GTP for GDP on RABs; Clathrin-mediated endocytosis" "2" "0" "0.952" "1.237" "1.185" "1.097" "1.250" "1.072" "0.809" "1.111" "3.784" "35.9" "34.1" "44.4" "42.5" "39.3" "44.8" "38.4" "29.0" "39.8" "135.7" "" "" "" "" "" "" "" "" "" "" "21.5" "17.7" "24.6" "20.0" "18.2" "23.0" "17.9" "13.0" "21.6" "135.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1748573463469303870" "False" "High" "IsMasterProtein" "Q99661" "Kinesin-like protein KIF2C OS=Homo sapiens OX=9606 GN=KIF2C PE=1 SV=2" "0.000" "False" "4.845" "3" "2" "2" "1" "725" "81.3" "7.83" "1.76" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00225" "11004" "ENSG00000142945" "KIF2C" "B3ITR9; hsa:11004; Q5JR88; Q6ICU1; Q96C18; Q96HB8; Q99661; Q9BWV8" "Microtubule cytoskeleton regulation" "MHC class II antigen presentation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "10" "0" "1.152" "1.593" "1.302" "1.091" "0.370" "1.444" "0.684" "1.129" "6.728" "10.1" "11.7" "16.1" "13.2" "11.0" "3.7" "14.6" "6.9" "11.4" "68.1" "" "" "" "" "" "" "" "" "" "" "6.1" "6.1" "8.9" "6.2" "5.1" "1.9" "6.8" "3.1" "6.2" "68.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1732426368668540463" "False" "High" "IsMasterProtein" "Q8N9N8" "Probable RNA-binding protein EIF1AD OS=Homo sapiens OX=9606 GN=EIF1AD PE=1 SV=1" "0.000" "False" "4.842" "10" "1" "1" "1" "165" "19.0" "5.21" "4.19" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01176" "84285" "ENSG00000175376" "EIF1AD" "B2R4N5; hsa:84285; Q8N9N8; Q9BSC1" "" "" "0" "0" "1.253" "1.517" "1.455" "1.383" "0.990" "1.664" "1.314" "1.818" "0.880" "19.7" "24.7" "29.9" "28.7" "27.3" "19.5" "32.8" "25.9" "35.8" "17.4" "" "" "" "" "" "" "" "" "" "" "11.8" "12.8" "16.6" "13.5" "12.6" "10.0" "15.2" "11.6" "19.4" "17.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5118939103406682552" "False" "High" "IsMasterProtein" "Q8TEX9" "Importin-4 OS=Homo sapiens OX=9606 GN=IPO4 PE=1 SV=2" "0.000" "False" "4.821" "2" "2" "2" "2" "1081" "118.6" "4.96" "3.01" "2" "transport;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03810, Pf13513" "79711" "ENSG00000196497; ENSG00000285248" "IPO4" "B2RN95; hsa:79711; Q2NL96; Q86TZ9; Q8NCG8; Q8TEX9; Q96SJ3; Q9BTI4; Q9H5L0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3928558694847449526" "False" "High" "IsMasterProtein" "Q9UBQ5" "Eukaryotic translation initiation factor 3 subunit K OS=Homo sapiens OX=9606 GN=EIF3K PE=1 SV=1" "0.000" "False" "4.806" "6" "1" "1" "1" "218" "25.0" "4.93" "3.19" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf10075" "27335" "ENSG00000178982; ENSG00000282986" "EIF3K" "A8K0I9; B7ZAM9; hsa:27335; Q96IQ0; Q9UBQ5; Q9Y6D1" "" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7428234003778738305" "False" "High" "IsMasterProtein" "Q9BRT2" "Ubiquinol-cytochrome c reductase complex assembly factor 2 OS=Homo sapiens OX=9606 GN=UQCC2 PE=1 SV=1" "0.000" "False" "4.802" "15" "2" "2" "2" "126" "14.9" "7.37" "4.44" "2" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion;nucleus" "" "Pf20180" "84300" "ENSG00000137288" "UQCC2" "B2R4I0; Q9BRT2" "Mitochondrial complex III assembly" "" "1" "0" "0.871" "0.913" "0.838" "1.032" "1.004" "0.785" "1.100" "0.961" "0.724" "157.3" "136.9" "143.6" "131.8" "162.3" "157.9" "123.5" "173.1" "151.1" "113.9" "" "" "" "" "" "" "" "" "" "" "94.1" "71.2" "79.5" "61.9" "75.2" "80.8" "57.4" "77.7" "82.0" "113.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9138201911436176215" "False" "High" "IsMasterProtein" "Q13952" "Nuclear transcription factor Y subunit gamma OS=Homo sapiens OX=9606 GN=NFYC PE=1 SV=3" "0.000" "False" "4.797" "4" "2" "2" "2" "458" "50.3" "6.10" "5.99" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "4802" "ENSG00000066136" "NFYC" "B4DUS6; B4DW63; D3DPV9; F8VWM3; hsa:4802; Q13952; Q59GY4; Q5T6K8; Q5T6K9; Q5T6L1; Q5TZR6; Q92869; Q9HBX1; Q9NXB5; Q9UM67; Q9UML0; Q9UMT7" "" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum stress; ATF6 (ATF6-alpha) activates chaperone genes" "5" "0" "1.023" "1.090" "0.993" "1.124" "1.125" "1.057" "1.030" "1.014" "0.900" "344.1" "352.0" "375.0" "341.8" "386.9" "387.1" "363.8" "354.3" "348.9" "309.7" "" "" "" "" "" "" "" "" "" "" "205.9" "182.9" "207.7" "160.5" "179.3" "198.2" "169.2" "159.1" "189.3" "309.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7356302297912569782" "False" "High" "IsMasterProtein" "O75400" "Pre-mRNA-processing factor 40 homolog A OS=Homo sapiens OX=9606 GN=PRPF40A PE=1 SV=2" "0.000" "False" "4.790" "2" "2" "2" "2" "957" "108.7" "7.56" "4.49" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf00397, Pf01846" "55660" "ENSG00000196504" "PRPF40A" "hsa:55660; O43856; O75400; O75404; Q8TBQ1; Q9H782; Q9NWU9; Q9P0Q2; Q9Y5A8" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.328" "1.248" "0.930" "0.885" "0.995" "0.913" "0.833" "1.105" "1.523" "59.8" "79.4" "74.7" "55.7" "52.9" "59.6" "54.6" "49.9" "66.1" "91.1" "" "" "" "" "" "" "" "" "" "" "35.8" "41.3" "41.3" "26.1" "24.5" "30.5" "25.4" "22.4" "35.9" "91.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2599348248423270713" "False" "High" "IsMasterProtein" "P23258" "Tubulin gamma-1 chain OS=Homo sapiens OX=9606 GN=TUBG1 PE=1 SV=2" "0.000" "False" "4.788" "4" "2" "2" "2" "451" "51.1" "6.14" "2.87" "2" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7283" "ENSG00000131462" "TUBG1" "hsa:7283; P23258; Q53X79; Q9BW59" "Alstrom syndrome" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4521329794053270042" "False" "High" "IsMasterProtein" "Q66K64" "DDB1- and CUL4-associated factor 15 OS=Homo sapiens OX=9606 GN=DCAF15 PE=1 SV=1" "0.000" "False" "4.780" "3" "1" "1" "1" "600" "66.4" "6.58" "3.09" "1" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf14939" "90379" "ENSG00000132017; ENSG00000288453" "DCAF15" "B3KS86; hsa:90379; Q66K64; Q96DW0; Q9BU31" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3211480978683405727" "False" "High" "IsMasterProtein" "O95232" "Luc7-like protein 3 OS=Homo sapiens OX=9606 GN=LUC7L3 PE=1 SV=2" "0.000" "False" "4.776" "3" "2" "4" "2" "432" "51.4" "9.79" "10.35" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf03194" "51747" "ENSG00000108848" "LUC7L3" "B3KN54; D3DTY1; hsa:51747; O95232; Q6PHR9; Q9NUY0; Q9P2S7" "" "mRNA Splicing - Major Pathway" "1" "0" "1.032" "1.055" "1.062" "1.116" "0.863" "1.038" "1.061" "1.085" "1.485" "272.5" "281.2" "287.4" "289.5" "304.2" "235.2" "282.8" "289.0" "295.5" "404.7" "" "" "" "" "" "" "" "" "" "" "163.1" "146.1" "159.1" "135.9" "141.0" "120.4" "131.5" "129.7" "160.3" "404.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7478830788962877121" "False" "High" "IsMasterProtein" "Q9Y3C4" "EKC/KEOPS complex subunit TPRKB OS=Homo sapiens OX=9606 GN=TPRKB PE=1 SV=1" "0.000" "False" "4.769" "12" "2" "3" "2" "175" "19.6" "6.79" "4.42" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08617" "51002" "ENSG00000144034; ENSG00000291480" "TPRKB" "D6W5H6; hsa:51002; Q8IWR6; Q8IWR7; Q9H3K4; Q9Y3C4" "" "tRNA modification in the nucleus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4271689599031996441" "False" "High" "IsMasterProtein" "Q9H1K1" "Iron-sulfur cluster assembly enzyme ISCU OS=Homo sapiens OX=9606 GN=ISCU PE=1 SV=2" "0.000" "False" "4.765" "10" "2" "2" "2" "167" "18.0" "9.48" "5.42" "2" "cell organization and biogenesis;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01592" "23479" "ENSG00000136003" "ISCU" "hsa:23479; Q6P713; Q99617; Q9H1K1; Q9H1K2" "Iron-sulfur cluster biogenesis" "Maturation of replicase proteins" "2" "0" "0.767" "1.053" "1.088" "1.203" "1.060" "1.116" "1.107" "1.144" "0.961" "28.6" "21.9" "30.1" "31.1" "34.4" "30.3" "31.9" "31.7" "32.7" "27.5" "" "" "" "" "" "" "" "" "" "" "17.1" "11.4" "16.7" "14.6" "16.0" "15.5" "14.8" "14.2" "17.8" "27.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1553540605597619179" "False" "High" "IsMasterProtein" "P51965" "Ubiquitin-conjugating enzyme E2 E1 OS=Homo sapiens OX=9606 GN=UBE2E1 PE=1 SV=1" "0.000" "False" "4.759" "12" "2" "3" "2" "193" "21.4" "8.53" "2.17" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7324" "ENSG00000170142" "UBE2E1" "B2RBX4; C9J8K2; hsa:7324; K4DI90; P51965" "Photodynamic therapy-induced unfolded protein response; 7q11.23 copy number variation syndrome" "Senescence-Associated Secretory Phenotype (SASP); Assembly of the pre-replicative complex; Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; ISG15 antiviral mechanism; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "23" "0" "1.330" "1.342" "1.297" "1.269" "1.262" "1.403" "0.873" "1.172" "3.987" "53.1" "70.6" "71.3" "68.9" "67.4" "67.0" "74.5" "46.3" "62.2" "211.7" "" "" "" "" "" "" "" "" "" "" "31.8" "36.7" "39.5" "32.3" "31.2" "34.3" "34.6" "20.8" "33.7" "211.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3778187452605941811" "False" "High" "IsMasterProtein" "Q9NZ52" "ADP-ribosylation factor-binding protein GGA3 OS=Homo sapiens OX=9606 GN=GGA3 PE=1 SV=1" "0.000" "False" "4.758" "2" "2" "2" "1" "723" "78.3" "5.58" "4.75" "2" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "23163" "ENSG00000125447" "GGA3" "B7Z7E2; B7Z7M9; hsa:23163; J3KRN0; Q15017; Q6IS16; Q9NZ52; Q9UJY3" "" "Amyloid fiber formation; TBC/RABGAPs; MET receptor recycling" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2268308097842944024" "False" "High" "IsMasterProtein" "Q9NPL8" "Complex I assembly factor TIMMDC1, mitochondrial OS=Homo sapiens OX=9606 GN=TIMMDC1 PE=1 SV=2" "0.000" "False" "4.752" "5" "1" "1" "1" "285" "32.2" "8.50" "3.91" "1" "" "other membranes;mitochondrion;nucleus" "" "Pf02466" "51300" "ENSG00000113845" "TIMMDC1" "D3DN81; hsa:51300; Q6IAJ7; Q6UWU6; Q9NPL8; Q9NPR3; Q9NPS5; Q9P0Y6" "" "Complex I biogenesis" "1" "0" "0.763" "1.050" "0.940" "0.823" "0.934" "0.784" "0.987" "0.909" "0.330" "55.9" "42.7" "58.7" "52.5" "46.0" "52.2" "43.8" "55.2" "50.8" "18.4" "" "" "" "" "" "" "" "" "" "" "33.5" "22.2" "32.5" "24.7" "21.3" "26.7" "20.4" "24.8" "27.6" "18.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1941330484708974901" "False" "High" "IsMasterProtein" "P18621" "Large ribosomal subunit protein uL22 OS=Homo sapiens OX=9606 GN=RPL17 PE=1 SV=3" "0.000" "False" "4.745" "9" "2" "3" "2" "184" "21.4" "10.17" "6.81" "2" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00237" "6139" "ENSG00000265681" "RPL17" "B2R4H3; B4E3C2; B5ME31; hsa:6139; J3QL51; P18621; Q3KQW2; Q6NZ54; Q7M4M5" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.768" "0.885" "0.903" "0.872" "1.012" "0.738" "0.842" "0.909" "1.745" "140.7" "108.1" "124.6" "127.1" "122.7" "142.5" "103.8" "118.6" "128.0" "245.6" "" "" "" "" "" "" "" "" "" "" "84.2" "56.2" "69.0" "59.7" "56.9" "73.0" "48.3" "53.2" "69.4" "245.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6713486079386730204" "False" "High" "IsMasterProtein" "P50454" "Serpin H1 OS=Homo sapiens OX=9606 GN=SERPINH1 PE=1 SV=2" "0.000" "False" "4.744" "4" "2" "2" "2" "418" "46.4" "8.69" "4.93" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes" "non-structural extracellular;other membranes;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00079" "871" "ENSG00000149257" "SERPINH1" "B3KVJ3; hsa:871; P29043; P50454; Q5XPB4; Q6NSJ6; Q8IY96; Q9NP88" "Endochondral ossification; Type I collagen synthesis in the context of osteogenesis imperfecta; Endochondral ossification with skeletal dysplasias; 15q13.3 copy number variation syndrome; 15q11q13 copy number variation" "Collagen biosynthesis and modifying enzymes" "6" "0" "0.842" "0.786" "1.200" "1.026" "0.906" "1.208" "1.271" "1.020" "0.800" "46.1" "38.8" "36.2" "55.3" "47.3" "41.8" "55.7" "58.6" "47.0" "36.9" "" "" "" "" "" "" "" "" "" "" "27.6" "20.2" "20.1" "26.0" "21.9" "21.4" "25.9" "26.3" "25.5" "36.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7171410217774938332" "False" "High" "IsMasterProtein" "Q96T51" "RUN and FYVE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RUFY1 PE=1 SV=2" "0.000" "False" "4.741" "3" "2" "2" "2" "708" "79.8" "5.74" "2.63" "2" "transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf02759" "80230" "ENSG00000176783; ENSG00000284260" "RUFY1" "hsa:80230; Q59FF3; Q71S93; Q96T51; Q9H6I3" "" "Synthesis of PIPs at the plasma membrane" "1" "0" "0.978" "1.168" "1.062" "1.251" "1.139" "1.030" "0.814" "1.099" "3.415" "88.2" "86.3" "103.1" "93.7" "110.4" "100.5" "90.9" "71.8" "97.0" "301.4" "" "" "" "" "" "" "" "" "" "" "52.8" "44.8" "57.1" "44.0" "51.2" "51.4" "42.3" "32.3" "52.6" "301.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "208143562843118343" "False" "High" "IsMasterProtein" "Q8NFH5" "Nucleoporin NUP35 OS=Homo sapiens OX=9606 GN=NUP35 PE=1 SV=1" "0.000" "False" "4.723" "8" "2" "2" "2" "326" "34.8" "9.09" "3.82" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05172" "129401" "ENSG00000163002" "NUP35" "B4DP57; B4DYB4; hsa:129401; Q4ZFZ9; Q53S95; Q8NFH5; Q8TDJ1" "" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; HCMV Early Events; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "0.900" "0.903" "0.901" "0.862" "0.817" "0.854" "1.035" "0.791" "0.550" "38.7" "34.8" "34.9" "34.8" "33.3" "31.6" "33.0" "40.0" "30.6" "21.3" "" "" "" "" "" "" "" "" "" "" "23.1" "18.1" "19.3" "16.4" "15.4" "16.2" "15.3" "18.0" "16.6" "21.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4037115124737055274" "False" "High" "IsMasterProtein" "P04439" "HLA class I histocompatibility antigen, A alpha chain OS=Homo sapiens OX=9606 GN=HLA-A PE=1 SV=2" "0.000" "False" "4.723" "6" "2" "2" "2" "365" "40.8" "6.00" "4.36" "2" "stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00129, Pf06623, Pf07654" "3105" "ENSG00000206503" "HLA-A" "B1PKZ3; hsa:3105; O02939; O02954; O02955; O02963; O19509; O19546; O19598; O19605; O19606; O19619; O19647; O19673; O19687; O19695; O19756; O19794; O19795; O43906; O43907; O46874; O62921; O62924; O77937; O77938; O77964; O78073; O78171; O98009; O98010; O98011; O98137; P01891; P01892; P04439; P05534; P06338; P10313; P10314; P10315; P10316; P13746; P16188; P16189; P16190; P18462; P30443; P30444; P30445; P30446; P30447; P30448; P30449; P30450; P30451; P30452; P30453; P30454; P30455; P30456; P30457; P30458; P30459; P30512; P30514; P79505; P79562; P79563; Q09160; Q29680; Q29747; Q29835; Q29837; Q29838; Q29899; Q29908; Q29909; Q29910; Q30208; Q31623; Q5S3G1; Q65A82; Q8MHM1; Q8MHN9; Q95352; Q95355; Q95362; Q95377; Q95380; Q95IZ5; Q9BCN0; Q9BD15; Q9BD19; Q9GJE6; Q9GJE7; Q9GJE8; Q9MW42; Q9MY89; Q9MYA3; Q9MYA5; Q9MYC4; Q9MYE6; Q9MYE9; Q9MYG4; Q9MYG5; Q9MYI5; Q9TP25; Q9TPQ3; Q9TPR8; Q9TPX8; Q9TPX9; Q9TPY0; Q9TQ24; Q9TQE8; Q9TQE9; Q9TQF1; Q9TQF5; Q9TQF8; Q9TQF9; Q9TQG0; Q9TQG5; Q9TQG7; Q9TQH5; Q9TQI3; Q9TQK5; Q9TQM6; Q9TQN5; Q9TQP5; Q9TQP6; Q9TQP7; Q9UIN1; Q9UIN2; Q9UIP7; Q9UQU3; Q9UQU6; Q9UQU7" "Proteasome degradation; Allograft rejection; Ebola virus infection in host; Cancer immunotherapy by PD-1 blockade; TAR syndrome" "E3 ubiquitin ligases ubiquitinate target proteins; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ER-Phagosome pathway; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon gamma signaling; Interferon alpha/beta signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Nef mediated downregulation of MHC class I complex cell surface expression; Endosomal/Vacuolar pathway" "14" "0" "1.050" "0.923" "1.253" "0.942" "1.082" "0.922" "0.985" "1.082" "0.567" "85.0" "89.2" "78.5" "106.5" "80.1" "92.0" "78.3" "83.7" "92.0" "48.2" "" "" "" "" "" "" "" "" "" "" "50.9" "46.4" "43.5" "50.0" "37.1" "47.1" "36.4" "37.6" "49.9" "48.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9059271771169400119" "False" "High" "IsMasterProtein" "Q9UBK9" "Protein UXT OS=Homo sapiens OX=9606 GN=UXT PE=1 SV=1" "0.000" "False" "4.721" "10" "2" "2" "2" "157" "18.2" "7.59" "5.02" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02996" "8409" "ENSG00000126756" "UXT" "A0A0C4DFR8; B2R561; hsa:8409; Q5JZG3; Q9UBK9; Q9Y6E5" "" "Transcriptional Regulation by E2F6" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6890831805190457766" "False" "High" "IsMasterProtein" "Q9BV73" "Centrosome-associated protein CEP250 OS=Homo sapiens OX=9606 GN=CEP250 PE=1 SV=2" "0.000" "False" "4.720" "1" "2" "2" "2" "2442" "281.0" "5.02" "2.23" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf15035" "11190" "ENSG00000126001" "CEP250" "E1P5Q3; hsa:11190; O14812; O60588; Q9BV73; Q9H450" "Mesodermal commitment pathway" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "8" "0" "0.677" "1.126" "1.040" "1.662" "0.907" "1.266" "1.437" "1.286" "2.471" "14.4" "9.8" "16.2" "15.0" "23.9" "13.1" "18.2" "20.7" "18.5" "35.6" "" "" "" "" "" "" "" "" "" "" "8.6" "5.1" "9.0" "7.0" "11.1" "6.7" "8.5" "9.3" "10.0" "35.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2819385337701029723" "False" "High" "IsMasterProtein" "Q9UHB9" "Signal recognition particle subunit SRP68 OS=Homo sapiens OX=9606 GN=SRP68 PE=1 SV=2" "0.000" "False" "4.713" "4" "1" "1" "1" "627" "70.7" "8.56" "3.36" "1" "other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf16969" "6730" "ENSG00000167881" "SRP68" "B3KUU5; B3KWY7; G3V1U4; hsa:6730; Q8NCJ4; Q8WUK2; Q9UHB9" "" "SRP-dependent cotranslational protein targeting to membrane" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "High" "1" "" "-7237194878275625611" "False" "High" "IsMasterProtein" "Q9Y224" "RNA transcription, translation and transport factor protein OS=Homo sapiens OX=9606 GN=RTRAF PE=1 SV=1" "0.000" "False" "4.699" "7" "2" "4" "2" "244" "28.1" "6.65" "7.89" "2" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10036" "51637" "ENSG00000087302" "RTRAF" "hsa:51637; Q9Y224" "" "tRNA processing in the nucleus" "1" "0" "1.246" "1.021" "1.443" "2.053" "1.260" "1.102" "1.256" "1.457" "1.635" "19.5" "24.3" "19.9" "28.1" "40.0" "24.5" "21.5" "24.5" "28.4" "31.8" "" "" "" "" "" "" "" "" "" "" "11.7" "12.6" "11.0" "13.2" "18.5" "12.6" "10.0" "11.0" "15.4" "31.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2292844797767435028" "False" "High" "IsMasterProtein" "Q9H074" "Polyadenylate-binding protein-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAIP1 PE=1 SV=1" "0.000" "False" "4.698" "3" "2" "2" "2" "479" "53.5" "4.81" "5.07" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf02854, Pf07145" "10605" "ENSG00000172239" "PAIP1" "A6NKV8; hsa:10605; O60455; Q96B61; Q9BS63; Q9H074" "Translation factors" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "4" "0" "1.077" "1.108" "1.073" "1.000" "0.984" "1.196" "1.167" "1.214" "1.183" "127.2" "137.1" "141.0" "136.5" "127.2" "125.2" "152.1" "148.4" "154.4" "150.5" "" "" "" "" "" "" "" "" "" "" "76.1" "71.2" "78.1" "64.1" "59.0" "64.1" "70.7" "66.6" "83.8" "150.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7159093635266280091" "False" "High" "IsMasterProtein" "O95295" "SNARE-associated protein Snapin OS=Homo sapiens OX=9606 GN=SNAPIN PE=1 SV=1" "0.000" "False" "4.694" "14" "2" "2" "2" "136" "14.9" "9.31" "5.16" "2" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf14712" "23557" "ENSG00000143553" "SNAPIN" "D3DV56; hsa:23557; O95295; Q5SXU8" "Alstrom syndrome" "Golgi Associated Vesicle Biogenesis" "2" "0" "0.916" "0.848" "0.952" "1.115" "0.928" "1.099" "1.048" "1.080" "1.094" "115.9" "106.2" "98.3" "110.4" "129.3" "107.6" "127.4" "121.5" "125.2" "126.8" "" "" "" "" "" "" "" "" "" "" "69.4" "55.2" "54.4" "51.8" "59.9" "55.1" "59.2" "54.5" "67.9" "126.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8065211085214910630" "False" "High" "IsMasterProtein" "Q96EL3" "Large ribosomal subunit protein mL53 OS=Homo sapiens OX=9606 GN=MRPL53 PE=1 SV=1" "0.000" "False" "4.680" "13" "1" "1" "1" "112" "12.1" "8.76" "2.76" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf10780" "116540" "ENSG00000204822" "MRPL53" "hsa:116540; Q96EL3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.091" "0.997" "0.638" "0.988" "0.994" "0.940" "0.773" "0.844" "1.382" "71.3" "77.7" "71.1" "45.5" "70.4" "70.9" "67.0" "55.1" "60.2" "98.5" "" "" "" "" "" "" "" "" "" "" "42.7" "40.4" "39.4" "21.3" "32.6" "36.3" "31.2" "24.7" "32.6" "98.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5104969040472016970" "False" "High" "IsMasterProtein" "Q13576" "Ras GTPase-activating-like protein IQGAP2 OS=Homo sapiens OX=9606 GN=IQGAP2 PE=1 SV=4" "0.000" "False" "4.678" "1" "2" "2" "2" "1575" "180.5" "5.64" "1.76" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00307, Pf00612, Pf00616, Pf03836" "10788" "ENSG00000145703" "IQGAP2" "A8K4V1; B7Z8A4; hsa:10788; J3KR91; Q13576" "Ciliary landscape; G13 signaling pathway" "Neutrophil degranulation; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RHO GTPases activate IQGAPs" "7" "0" "1.286" "0.917" "1.129" "1.727" "1.475" "2.004" "0.408" "1.818" "6.033" "8.7" "11.2" "8.0" "9.9" "15.1" "12.9" "17.5" "3.6" "15.9" "52.6" "" "" "" "" "" "" "" "" "" "" "5.2" "5.8" "4.4" "4.6" "7.0" "6.6" "8.1" "1.6" "8.6" "52.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7220611050320335909" "False" "High" "IsMasterProtein" "Q8TDH9" "Biogenesis of lysosome-related organelles complex 1 subunit 5 OS=Homo sapiens OX=9606 GN=BLOC1S5 PE=1 SV=1" "0.000" "False" "4.670" "9" "2" "2" "2" "187" "21.6" "7.59" "3.42" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "ER/Golgi;other cell component" "" "Pf14942" "63915" "ENSG00000188428" "BLOC1S5" "B4DVM2; hsa:63915; Q0VDJ6; Q0VDJ7; Q5THS1; Q68D56; Q8N5F9; Q8TDH9; Q9NU16" "" "" "0" "0" "1.259" "0.897" "0.981" "1.152" "1.303" "1.111" "1.525" "1.138" "0.748" "42.2" "53.1" "37.8" "41.4" "48.6" "55.0" "46.8" "64.3" "48.0" "31.6" "" "" "" "" "" "" "" "" "" "" "25.2" "27.6" "21.0" "19.4" "22.5" "28.1" "21.8" "28.9" "26.1" "31.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2325443013124673649" "False" "High" "IsMasterProtein" "Q6NXE6" "Armadillo repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=ARMC6 PE=1 SV=2" "0.000" "False" "4.667" "2" "1" "1" "1" "501" "54.1" "6.24" "3.02" "1" "other biological processes" "cytosol" "" "Pf00514" "93436" "ENSG00000105676" "ARMC6" "B4DI98; hsa:93436; O94999; Q6NXE6; Q9BTH5" "" "" "0" "0" "0.984" "0.847" "1.015" "0.831" "0.950" "0.844" "0.830" "0.882" "3.315" "54.7" "53.8" "46.3" "55.5" "45.4" "51.9" "46.1" "45.4" "48.2" "181.2" "" "" "" "" "" "" "" "" "" "" "32.7" "27.9" "25.6" "26.0" "21.1" "26.6" "21.4" "20.4" "26.2" "181.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6062683060595135562" "False" "High" "IsMasterProtein" "Q9NVE7" "4'-phosphopantetheine phosphatase OS=Homo sapiens OX=9606 GN=PANK4 PE=1 SV=1" "0.000" "False" "4.665" "3" "2" "2" "2" "773" "85.9" "6.28" "2.32" "2" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01937, Pf03630" "55229" "ENSG00000157881; ENSG00000273494" "PANK4" "B9DI84; hsa:55229; Q53EU3; Q5TA84; Q7RTX3; Q9H3X5; Q9NVE7" "1p36 copy number variation syndrome" "Vitamin B5 (pantothenate) metabolism" "2" "0" "0.752" "0.781" "0.869" "0.914" "1.289" "0.859" "0.760" "0.978" "0.959" "43.1" "32.4" "33.6" "37.4" "39.4" "55.5" "37.0" "32.8" "42.1" "41.3" "" "" "" "" "" "" "" "" "" "" "25.8" "16.8" "18.6" "17.6" "18.2" "28.4" "17.2" "14.7" "22.9" "41.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5402441647647125323" "False" "High" "IsMasterProtein" "O75880" "Protein SCO1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=SCO1 PE=1 SV=1" "0.000" "False" "4.664" "5" "2" "3" "2" "301" "33.8" "8.88" "6.77" "2" "cell organization and biogenesis;other biological processes" "other membranes;cytoskeleton;mitochondrion" "other molecular function" "Pf02630" "6341" "ENSG00000133028" "SCO1" "B2RDM0; hsa:6341; O75880" "Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3621833610637206208" "False" "High" "IsMasterProtein" "Q92623" "Tetratricopeptide repeat protein 9A OS=Homo sapiens OX=9606 GN=TTC9 PE=1 SV=3" "0.000" "False" "4.651" "6" "1" "1" "1" "222" "24.4" "8.98" "3.20" "1" "developmental processes" "" "" "" "23508" "ENSG00000133985" "TTC9" "hsa:23508; Q86WT2; Q92623" "Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604354164667528726" "False" "High" "IsMasterProtein" "Q13769" "THO complex subunit 5 homolog OS=Homo sapiens OX=9606 GN=THOC5 PE=1 SV=2" "0.000" "False" "4.644" "2" "2" "2" "2" "683" "78.5" "6.87" "4.55" "2" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09766" "8563" "ENSG00000100296" "THOC5" "hsa:8563; O60839; Q13769; Q9UPZ5" "" "Signaling by CSF1 (M-CSF) in myeloid cells; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "4" "0" "1.387" "1.225" "1.336" "1.131" "1.267" "1.235" "1.255" "1.471" "3.153" "41.7" "57.9" "51.1" "55.8" "47.2" "52.9" "51.6" "52.4" "61.4" "131.6" "" "" "" "" "" "" "" "" "" "" "25.0" "30.1" "28.3" "26.2" "21.9" "27.1" "24.0" "23.5" "33.3" "131.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7526425454586707099" "False" "High" "IsMasterProtein" "Q8TE02" "Elongator complex protein 5 OS=Homo sapiens OX=9606 GN=ELP5 PE=1 SV=3" "0.000" "False" "4.633" "6" "2" "2" "2" "300" "33.2" "4.98" "4.90" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10483" "23587" "ENSG00000170291; ENSG00000288485" "ELP5" "A8K1M5; D3DTN9; Q659B6; Q7Z2T4; Q8TDR9; Q8TE02; Q9BUB2; Q9Y2Q4" "" "HATs acetylate histones" "1" "0" "0.969" "0.996" "0.989" "1.118" "0.975" "1.093" "0.885" "1.010" "0.761" "93.5" "90.5" "93.1" "92.4" "104.5" "91.2" "102.1" "82.8" "94.4" "71.1" "" "" "" "" "" "" "" "" "" "" "55.9" "47.0" "51.5" "43.4" "48.4" "46.7" "47.5" "37.2" "51.2" "71.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3382226448836069029" "False" "High" "IsMasterProtein" "Q69YH5" "Cell division cycle-associated protein 2 OS=Homo sapiens OX=9606 GN=CDCA2 PE=1 SV=2" "0.000" "False" "4.628" "4" "2" "2" "2" "1023" "112.6" "8.40" "0.00" "2" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "" "Pf15276" "157313" "ENSG00000184661" "CDCA2" "hsa:157313; Q3SX74; Q4G0W0; Q5RKN0; Q69YH5; Q69YI4; Q6P464; Q8N7C1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6471377721056749589" "False" "High" "IsMasterProtein" "Cont_Q58D62" "Fetuin-B OS=Bos taurus OX=9913 GN=FETUB PE=1 SV=1" "0.000" "True" "4.623" "4" "2" "4" "2" "387" "42.6" "5.77" "7.41" "2" "other biological processes" "non-structural extracellular" "enzyme regulator activity" "Pf00031" "504615" "ENSBTAG00000017531" "FETUB" "bta:504615; Q58D62" "" "" "0" "0" "1.550" "1.403" "2.198" "1.969" "1.505" "1.827" "1.215" "1.393" "0.652" "14.0" "21.7" "19.7" "30.8" "27.6" "21.1" "25.6" "17.0" "19.5" "9.1" "" "" "" "" "" "" "" "" "" "" "8.4" "11.3" "10.9" "14.5" "12.8" "10.8" "11.9" "7.7" "10.6" "9.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5573084200900719321" "False" "High" "IsMasterProtein" "Q9Y5V0" "Zinc finger protein 706 OS=Homo sapiens OX=9606 GN=ZNF706 PE=1 SV=1" "0.000" "False" "4.619" "30" "2" "4" "2" "76" "8.5" "10.01" "3.62" "2" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf04419, Pf12874" "51123" "ENSG00000120963" "ZNF706" "A8K362; hsa:51123; Q9Y5V0" "" "Generic Transcription Pathway" "1" "0" "0.957" "1.277" "1.039" "0.960" "0.934" "0.929" "0.840" "0.953" "1.008" "49.0" "46.9" "62.6" "50.9" "47.1" "45.8" "45.5" "41.2" "46.7" "49.4" "" "" "" "" "" "" "" "" "" "" "29.3" "24.4" "34.7" "23.9" "21.8" "23.5" "21.2" "18.5" "25.4" "49.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4980915021063436064" "False" "High" "IsMasterProtein" "Q9H944" "Mediator of RNA polymerase II transcription subunit 20 OS=Homo sapiens OX=9606 GN=MED20 PE=1 SV=1" "0.000" "False" "4.618" "5" "1" "1" "1" "212" "23.2" "6.87" "3.11" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf08612" "9477" "ENSG00000124641" "MED20" "B4DE08; hsa:9477; O95821; Q5T8J4; Q9H944; Q9Y429" "" "Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; RSV-host interactions; Generic Transcription Pathway" "4" "0" "1.238" "1.071" "1.125" "1.458" "1.270" "1.425" "1.163" "1.295" "1.690" "29.4" "36.4" "31.5" "33.1" "42.8" "37.3" "41.9" "34.2" "38.1" "49.7" "" "" "" "" "" "" "" "" "" "" "17.6" "18.9" "17.4" "15.5" "19.9" "19.1" "19.5" "15.3" "20.6" "49.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7016247097338811422" "False" "High" "IsMasterProtein" "Q9NW64" "Pre-mRNA-splicing factor RBM22 OS=Homo sapiens OX=9606 GN=RBM22 PE=1 SV=1" "0.000" "False" "4.617" "2" "1" "1" "1" "420" "46.9" "8.54" "3.50" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf21369" "55696" "ENSG00000086589" "RBM22" "A6NDM5; B4DLI9; hsa:55696; O95607; Q9NW64" "" "mRNA Splicing - Major Pathway" "1" "0" "1.359" "1.658" "1.096" "1.139" "1.602" "1.603" "1.294" "1.682" "3.832" "47.2" "64.2" "78.3" "51.8" "53.8" "75.6" "75.7" "61.1" "79.5" "181.0" "" "" "" "" "" "" "" "" "" "" "28.3" "33.4" "43.4" "24.3" "24.9" "38.7" "35.2" "27.4" "43.1" "181.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1467078136555344062" "False" "High" "IsMasterProtein" "Q8NHZ8" "Anaphase-promoting complex subunit CDC26 OS=Homo sapiens OX=9606 GN=CDC26 PE=1 SV=1" "0.000" "False" "4.608" "26" "1" "1" "1" "85" "9.8" "6.81" "2.10" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf10471" "246184" "ENSG00000176386" "CDC26" "hsa:246184; Q8NHZ8" "" "Senescence-Associated Secretory Phenotype (SASP); Assembly of the pre-replicative complex; Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9156757260988577689" "False" "High" "IsMasterProtein" "P0DJD0" "RANBP2-like and GRIP domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RGPD1 PE=2 SV=1" "0.000" "False" "4.597" "1" "2" "2" "1" "1748" "196.5" "6.14" "2.43" "2" "transport" "nucleus;other cell component" "" "Pf00638, Pf01465, Pf16704" "400966" "" "RGPD1" "hsa:400966; P0C839; P0DJD0; Q68DN6; Q6V1X0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5656635003875974689" "False" "High" "IsMasterProtein" "Q13111" "Chromatin assembly factor 1 subunit A OS=Homo sapiens OX=9606 GN=CHAF1A PE=1 SV=3" "0.000" "False" "4.596" "3" "2" "3" "2" "956" "106.8" "5.94" "2.14" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf11600, Pf12253, Pf15539, Pf15557" "10036" "ENSG00000167670" "CHAF1A" "hsa:10036; Q13111; Q6NXG5; Q7Z7K3; Q9UJY8" "Nanoparticle triggered autophagic cell death" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4794546056511531982" "False" "High" "IsMasterProtein" "Q969Q5" "Ras-related protein Rab-24 OS=Homo sapiens OX=9606 GN=RAB24 PE=1 SV=1" "0.000" "False" "4.594" "8" "2" "2" "2" "203" "23.1" "6.23" "5.17" "2" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "53917" "ENSG00000169228" "RAB24" "A0A024R7N9; hsa:53917; Q7Z4Z7; Q969Q5" "5q35 copy number variation" "Neutrophil degranulation; RAB geranylgeranylation" "3" "0" "1.069" "1.157" "1.165" "1.236" "1.116" "1.158" "1.128" "1.072" "1.277" "120.4" "128.7" "139.3" "140.3" "148.9" "134.4" "139.5" "135.8" "129.1" "153.7" "" "" "" "" "" "" "" "" "" "" "72.1" "66.9" "77.1" "65.9" "69.0" "68.8" "64.8" "61.0" "70.0" "153.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3086265819139452668" "False" "High" "IsMasterProtein" "O14773" "Tripeptidyl-peptidase 1 OS=Homo sapiens OX=9606 GN=TPP1 PE=1 SV=2" "0.000" "False" "4.590" "2" "1" "2" "1" "563" "61.2" "6.48" "8.38" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00082, Pf09286" "1200" "ENSG00000166340" "TPP1" "hsa:1200; O14773; Q53HT1; Q5JAK6; Q6UX56; Q71JP6; Q96C37" "VEGFA-VEGFR2 signaling" "XBP1(S) activates chaperone genes" "2" "0" "0.893" "0.836" "0.924" "1.028" "0.849" "0.990" "0.872" "0.918" "0.826" "194.5" "173.6" "162.6" "179.8" "200.0" "165.2" "192.6" "169.6" "178.4" "160.7" "" "" "" "" "" "" "" "" "" "" "116.4" "90.2" "90.1" "84.4" "92.7" "84.6" "89.5" "76.1" "96.8" "160.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3640417393520932039" "False" "High" "IsMasterProtein" "Q9P031" "Thyroid transcription factor 1-associated protein 26 OS=Homo sapiens OX=9606 GN=CCDC59 PE=1 SV=2" "0.000" "False" "4.576" "5" "1" "1" "1" "241" "28.7" "9.88" "2.97" "1" "" "nucleus" "" "Pf08524" "29080" "ENSG00000133773" "CCDC59" "hsa:29080; Q9H2V5; Q9NW62; Q9P031" "" "Surfactant metabolism" "1" "0" "1.064" "1.106" "1.090" "0.919" "1.125" "1.152" "0.834" "1.066" "0.833" "37.5" "39.9" "41.4" "40.8" "34.4" "42.2" "43.2" "31.2" "40.0" "31.2" "" "" "" "" "" "" "" "" "" "" "22.4" "20.7" "23.0" "19.2" "16.0" "21.6" "20.1" "14.0" "21.7" "31.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5696513608973606523" "False" "High" "IsMasterProtein" "Q86VQ1" "Glucocorticoid-induced transcript 1 protein OS=Homo sapiens OX=9606 GN=GLCCI1 PE=1 SV=1" "0.000" "False" "4.564" "4" "2" "2" "2" "547" "58.0" "9.44" "4.05" "2" "" "other cell component" "" "Pf15388" "113263" "ENSG00000106415" "GLCCI1" "A4D103; hsa:113263; Q86VQ1; Q96FD0" "" "" "0" "0" "1.060" "0.979" "0.822" "1.115" "1.058" "0.837" "1.084" "0.909" "0.655" "71.8" "76.1" "70.3" "59.0" "80.0" "76.0" "60.1" "77.8" "65.3" "47.0" "" "" "" "" "" "" "" "" "" "" "43.0" "39.5" "38.9" "27.7" "37.1" "38.9" "27.9" "34.9" "35.4" "47.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3915104900764818222" "False" "High" "IsMasterProtein" "Q86TG7" "Retrotransposon-derived protein PEG10 OS=Homo sapiens OX=9606 GN=PEG10 PE=1 SV=2" "0.000" "False" "4.549" "2" "1" "1" "1" "708" "80.1" "6.39" "3.51" "1" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf16297" "23089" "ENSG00000242265" "PEG10" "B4DSP0; hsa:23089; Q86TG7; Q96A68; Q9UPV1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6896293366325971592" "False" "High" "IsMasterProtein" "Q8WWK9" "Cytoskeleton-associated protein 2 OS=Homo sapiens OX=9606 GN=CKAP2 PE=1 SV=1" "0.000" "False" "4.539" "2" "2" "2" "2" "683" "76.9" "9.41" "4.35" "2" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "" "Pf15297" "26586" "ENSG00000136108" "CKAP2" "A2BDE0; A5YM58; B4DR35; E9PD90; hsa:26586; Q3KRA5; Q5VXB4; Q8IWV5; Q8IWV6; Q8WWK9; Q96FH9; Q9H012; Q9H0D0; Q9H988; Q9HC49; Q9NVG4" "" "" "0" "0" "1.246" "1.150" "1.030" "0.879" "1.230" "1.258" "1.140" "1.191" "2.107" "47.4" "59.1" "54.5" "48.8" "41.7" "58.3" "59.6" "54.0" "56.5" "99.9" "" "" "" "" "" "" "" "" "" "" "28.4" "30.7" "30.2" "22.9" "19.3" "29.8" "27.7" "24.3" "30.6" "99.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5017693853216972141" "False" "High" "IsMasterProtein" "Q969S3" "Cytoplasmic 60S subunit biogenesis factor ZNF622 OS=Homo sapiens OX=9606 GN=ZNF622 PE=1 SV=1" "0.000" "False" "4.532" "4" "2" "2" "2" "477" "54.2" "6.15" "4.94" "2" "signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf12171, Pf12756" "90441" "ENSG00000173545" "ZNF622" "hsa:90441; Q969S3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8551300482488071361" "False" "High" "IsMasterProtein" "P78332" "RNA-binding protein 6 OS=Homo sapiens OX=9606 GN=RBM6 PE=1 SV=5" "0.000" "False" "4.527" "2" "2" "2" "2" "1123" "128.6" "6.32" "4.60" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf01585, Pf17780" "10180" "ENSG00000004534" "RBM6" "B4E0G6; hsa:10180; O60549; O75524; P78332; Q86SS3" "" "" "0" "0" "1.048" "0.994" "1.429" "1.504" "1.117" "1.458" "1.104" "1.379" "1.219" "38.8" "40.6" "38.5" "55.4" "58.3" "43.3" "56.5" "42.8" "53.5" "47.3" "" "" "" "" "" "" "" "" "" "" "23.2" "21.1" "21.3" "26.0" "27.0" "22.2" "26.3" "19.2" "29.0" "47.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1344142120960836563" "False" "High" "IsMasterProtein" "Q9BWS9" "Chitinase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHID1 PE=1 SV=1" "0.000" "False" "4.517" "4" "2" "2" "2" "393" "44.9" "8.63" "5.26" "2" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00704" "66005" "ENSG00000177830" "CHID1" "B3KWB0; hsa:66005; Q8NBM9; Q96CZ3; Q96S93; Q96SK0; Q9BWS9; Q9BY52" "" "Platelet degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5291509197618805102" "False" "High" "IsMasterProtein" "Cont_Q3SZ57" "Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1" "0.000" "True" "4.515" "2" "2" "9" "1" "610" "68.5" "6.29" "21.92" "2" "other metabolic processes;developmental processes;signal transduction" "non-structural extracellular;other cell component" "other molecular function" "Pf00273" "506011" "ENSBIXG00000005150; ENSBTAG00000017131" "AFP" "A0A4W2DDK5; bta:506011; Q3SZ57" "" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "2" "0" "1.051" "1.153" "1.078" "0.915" "0.973" "1.173" "1.094" "1.010" "0.733" "101.4" "106.5" "116.9" "109.3" "92.8" "98.6" "119.0" "110.9" "102.4" "74.3" "" "" "" "" "" "" "" "" "" "" "60.7" "55.4" "64.8" "51.3" "43.0" "50.5" "55.3" "49.8" "55.6" "74.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6447964159336659836" "False" "High" "IsMasterProtein" "Q9UL15" "BAG family molecular chaperone regulator 5 OS=Homo sapiens OX=9606 GN=BAG5 PE=1 SV=1" "0.000" "False" "4.514" "3" "2" "2" "2" "447" "51.2" "6.05" "4.70" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf02179" "9529" "ENSG00000166170" "BAG5" "hsa:9529; O94950; Q86W59; Q9UL15" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "0.601" "0.962" "0.720" "0.897" "0.612" "0.924" "0.376" "0.758" "2.447" "36.8" "22.1" "35.4" "26.5" "33.1" "22.5" "34.1" "13.9" "27.9" "90.1" "" "" "" "" "" "" "" "" "" "" "22.0" "11.5" "19.6" "12.4" "15.3" "11.5" "15.8" "6.2" "15.1" "90.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5479231618500312272" "False" "High" "IsMasterProtein" "Q8NF91" "Nesprin-1 OS=Homo sapiens OX=9606 GN=SYNE1 PE=1 SV=4" "0.000" "False" "4.508" "0" "3" "3" "3" "8797" "1010.5" "5.53" "6.56" "3" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf10541" "23345" "ENSG00000131018" "SYNE1" "B3W695; E7EQI5; H0Y4C0; O94890; Q3ZCV0; Q5JV19; Q5JV22; Q8N9P7; Q8NF91; Q8TCP1; Q8WWW6; Q8WWW7; Q8WXF6; Q96N17; Q9C0A7; Q9H525; Q9H526; Q9NS36; Q9NU50; Q9UJ06; Q9UJ07; Q9ULF8" "Envelope proteins and their potential roles in EDMD physiopathology" "Meiotic synapsis" "2" "0" "0.982" "0.883" "1.014" "0.856" "0.888" "1.034" "1.000" "1.128" "0.607" "156.9" "154.2" "138.6" "159.1" "134.3" "139.4" "162.3" "156.9" "177.0" "95.3" "" "" "" "" "" "" "" "" "" "" "93.9" "80.1" "76.7" "74.7" "62.2" "71.4" "75.5" "70.4" "96.1" "95.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5299456138050834551" "False" "High" "IsMasterProtein" "O00115" "Deoxyribonuclease-2-alpha OS=Homo sapiens OX=9606 GN=DNASE2 PE=1 SV=2" "0.000" "False" "4.507" "3" "1" "1" "1" "360" "39.6" "8.05" "3.73" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf03265" "1777" "ENSG00000105612" "DNASE2" "B2RD06; B7Z4K6; hsa:1777; O00115; O43910" "" "Lysosome Vesicle Biogenesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "300613952239317335" "False" "High" "IsMasterProtein" "O43766" "Lipoyl synthase, mitochondrial OS=Homo sapiens OX=9606 GN=LIAS PE=1 SV=3" "0.000" "False" "4.497" "7" "2" "2" "2" "372" "41.9" "8.59" "2.21" "2" "other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion" "other molecular function" "Pf04055, Pf16881" "11019" "ENSG00000121897" "LIAS" "A8K873; C9JCF6; hsa:11019; O43766; Q8IV62" "" "Glyoxylate metabolism and glycine degradation" "1" "0" "1.009" "0.975" "1.449" "1.240" "0.823" "1.068" "1.075" "1.329" "0.793" "21.3" "21.5" "20.8" "30.9" "26.5" "17.6" "22.8" "22.9" "28.4" "16.9" "" "" "" "" "" "" "" "" "" "" "12.8" "11.2" "11.5" "14.5" "12.3" "9.0" "10.6" "10.3" "15.4" "16.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3430961605673792526" "False" "High" "IsMasterProtein" "Q13033" "Striatin-3 OS=Homo sapiens OX=9606 GN=STRN3 PE=1 SV=3" "0.000" "False" "4.489" "2" "2" "2" "2" "797" "87.2" "5.36" "5.77" "2" "other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00400, Pf08232" "29966" "ENSG00000196792" "STRN3" "A2RTX7; A6NHZ7; hsa:29966; Q13033; Q9NRA5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-829436805144986471" "False" "High" "IsMasterProtein" "P61927" "Large ribosomal subunit protein eL37 OS=Homo sapiens OX=9606 GN=RPL37 PE=1 SV=2" "0.000" "False" "4.488" "16" "2" "3" "2" "97" "11.1" "11.74" "7.10" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01907" "6167" "ENSG00000145592" "RPL37" "B2R4H2; hsa:6167; P02403; P61927; Q6IBB4; Q99883" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis" "14" "0" "0.932" "1.082" "0.886" "0.861" "0.924" "0.793" "0.823" "1.088" "1.392" "455.6" "424.8" "492.8" "403.4" "392.2" "420.8" "361.2" "375.0" "495.7" "634.1" "" "" "" "" "" "" "" "" "" "" "272.6" "220.8" "272.9" "189.4" "181.8" "215.4" "168.0" "168.3" "268.9" "634.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5015398897820644174" "False" "High" "IsMasterProtein" "O14757" "Serine/threonine-protein kinase Chk1 OS=Homo sapiens OX=9606 GN=CHEK1 PE=1 SV=2" "0.000" "False" "4.473" "4" "2" "2" "2" "476" "54.4" "8.25" "4.07" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1111" "ENSG00000149554" "CHEK1" "A8K934; B4DDD0; B4DSK3; B5BTY6; F5H7S4; H2BI51; hsa:1111; O14757" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATR signaling; ATM signaling in development and disease ; DNA repair pathways, full network; TROP2 regulatory signaling; DNA damage response" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Transcriptional Regulation by E2F6; Signaling by SCF-KIT; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex" "18" "0" "0.933" "0.901" "1.022" "0.713" "0.854" "0.947" "0.815" "0.778" "1.448" "81.4" "76.0" "73.3" "83.1" "58.0" "69.5" "77.1" "66.3" "63.3" "117.8" "" "" "" "" "" "" "" "" "" "" "48.7" "39.5" "40.6" "39.0" "26.9" "35.6" "35.8" "29.8" "34.4" "117.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-431742904065760490" "False" "High" "IsMasterProtein" "O75955" "Flotillin-1 OS=Homo sapiens OX=9606 GN=FLOT1 PE=1 SV=3" "0.000" "False" "4.472" "4" "2" "2" "2" "427" "47.3" "7.49" "5.16" "2" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01145" "10211" "ENSG00000137312; ENSG00000206379; ENSG00000206480; ENSG00000230143; ENSG00000232280" "FLOT1" "B4DVY7; hsa:10211; O75955; Q969J8; Q9UHW1; Q9UNV8" "Angiopoietin-like protein 8 regulatory pathway; Insulin signaling" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Regulation of necroptotic cell death; Synaptic adhesion-like molecules" "8" "0" "1.074" "0.959" "1.158" "1.135" "1.207" "1.175" "1.199" "1.256" "0.720" "125.0" "134.2" "119.9" "144.8" "141.8" "150.9" "146.9" "149.8" "157.1" "90.0" "" "" "" "" "" "" "" "" "" "" "74.8" "69.8" "66.4" "68.0" "65.7" "77.3" "68.3" "67.3" "85.2" "90.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4095542091731415933" "False" "High" "IsMasterProtein" "Q9HA47" "Uridine-cytidine kinase 1 OS=Homo sapiens OX=9606 GN=UCK1 PE=1 SV=1" "0.000" "False" "4.469" "5" "2" "2" "1" "277" "31.4" "7.30" "4.93" "2" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00485" "83549" "ENSG00000130717" "UCK1" "hsa:83549; Q5JT09; Q5JT10; Q5JT12; Q5JT13; Q6IA74; Q96BJ0; Q9HA47" "Fluoropyrimidine activity; Pyrimidine metabolism; IL-18 signaling pathway" "Pyrimidine salvage" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5324652532582305658" "False" "High" "IsMasterProtein" "P53779" "Mitogen-activated protein kinase 10 OS=Homo sapiens OX=9606 GN=MAPK10 PE=1 SV=2" "0.000" "False" "4.466" "5" "2" "5" "1" "464" "52.6" "6.79" "9.62" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5602" "ENSG00000109339" "MAPK10" "A6NFS3; A6NG28; B3KQ94; hsa:5602; P53779; Q15707; Q49AP1" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Focal adhesion; MAPK signaling pathway; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; Angiopoietin-like protein 8 regulatory pathway; Oxidative damage response; Wnt signaling pathway and pluripotency; Oxidative stress response; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Regulatory circuits of the STAT3 signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Hepatitis B infection; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Alzheimer's disease; G13 signaling pathway; 5q35 copy number variation; ErbB signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Activation of the AP-1 family of transcription factors" "36" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8786307772961790223" "False" "High" "IsMasterProtein" "Q6QNY1" "Biogenesis of lysosome-related organelles complex 1 subunit 2 OS=Homo sapiens OX=9606 GN=BLOC1S2 PE=1 SV=1" "0.000" "False" "4.443" "8" "1" "1" "1" "142" "16.0" "4.86" "3.15" "1" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf10046" "282991" "ENSG00000196072" "BLOC1S2" "B4DQV2; hsa:282991; Q5W040; Q6QNY1; Q8WUI8" "" "" "0" "0" "0.949" "0.708" "0.873" "1.460" "1.051" "1.422" "1.010" "1.130" "1.357" "28.2" "26.8" "19.9" "24.6" "41.1" "29.6" "40.1" "28.4" "31.8" "38.2" "" "" "" "" "" "" "" "" "" "" "16.9" "13.9" "11.0" "11.5" "19.1" "15.2" "18.6" "12.8" "17.3" "38.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2137226823831967498" "False" "High" "IsMasterProtein" "Q0VD83" "Apolipoprotein B receptor OS=Homo sapiens OX=9606 GN=APOBR PE=1 SV=3" "0.000" "False" "4.436" "2" "2" "2" "2" "1097" "115.6" "4.40" "3.17" "2" "other metabolic processes;transport" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "" "55911" "ENSG00000184730" "APOBR" "H3BU97; hsa:55911; Q0VD81; Q0VD83; Q8NC15; Q9NPJ9" "" "VLDL clearance" "1" "0" "0.881" "0.753" "0.788" "0.954" "0.806" "0.914" "0.877" "0.825" "0.705" "80.3" "70.7" "60.5" "63.2" "76.6" "64.7" "73.4" "70.4" "66.3" "56.6" "" "" "" "" "" "" "" "" "" "" "48.0" "36.8" "33.5" "29.7" "35.5" "33.1" "34.1" "31.6" "36.0" "56.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "394232053154577892" "False" "High" "IsMasterProtein" "Q92530" "Proteasome inhibitor PI31 subunit OS=Homo sapiens OX=9606 GN=PSMF1 PE=1 SV=2" "0.000" "False" "4.424" "7" "2" "4" "2" "271" "29.8" "5.74" "6.06" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf08577, Pf11566" "9491" "ENSG00000125818" "PSMF1" "A0AVQ9; D3DVW3; hsa:9491; Q92530; Q9H4I1" "" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "59" "0" "0.929" "0.887" "1.043" "1.074" "0.953" "1.003" "1.094" "0.833" "0.928" "46.8" "43.5" "41.5" "48.8" "50.3" "44.6" "46.9" "51.2" "39.0" "43.4" "" "" "" "" "" "" "" "" "" "" "28.0" "22.6" "23.0" "22.9" "23.3" "22.8" "21.8" "23.0" "21.1" "43.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5639426559288223252" "False" "High" "IsMasterProtein" "Q9UMX5" "Neudesin OS=Homo sapiens OX=9606 GN=NENF PE=1 SV=1" "0.000" "False" "4.406" "5" "1" "1" "1" "172" "18.8" "5.69" "3.60" "1" "signal transduction;other biological processes" "non-structural extracellular;other membranes;mitochondrion;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00173" "29937" "ENSG00000117691" "NENF" "A1KYQ8; hsa:29937; Q53FZ6; Q5TM90; Q9UMX5" "" "" "0" "0" "1.127" "1.109" "0.939" "1.072" "0.991" "1.007" "1.170" "0.974" "0.635" "91.4" "103.0" "101.3" "85.8" "97.9" "90.5" "92.0" "106.9" "89.0" "58.0" "" "" "" "" "" "" "" "" "" "" "54.7" "53.5" "56.1" "40.3" "45.4" "46.3" "42.8" "48.0" "48.3" "58.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6930052097087835026" "False" "High" "IsMasterProtein" "Q15003" "Condensin complex subunit 2 OS=Homo sapiens OX=9606 GN=NCAPH PE=1 SV=3" "0.000" "False" "4.396" "3" "2" "2" "2" "741" "82.5" "5.06" "3.10" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05786" "23397" "ENSG00000121152" "NCAPH" "B4E189; hsa:23397; Q15003; Q8TB87" "2q11.2 copy number variation syndrome" "Condensation of Prometaphase Chromosomes" "2" "0" "1.570" "1.188" "1.507" "1.870" "1.234" "1.288" "1.319" "0.943" "4.796" "10.7" "16.7" "12.7" "16.1" "19.9" "13.2" "13.7" "14.1" "10.1" "51.1" "" "" "" "" "" "" "" "" "" "" "6.4" "8.7" "7.0" "7.5" "9.2" "6.7" "6.4" "6.3" "5.5" "51.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3344145202623347770" "False" "High" "IsMasterProtein" "O60637" "Tetraspanin-3 OS=Homo sapiens OX=9606 GN=TSPAN3 PE=1 SV=1" "0.000" "False" "4.387" "6" "2" "2" "2" "253" "28.0" "5.81" "5.82" "2" "" "other membranes" "" "Pf00335" "10099" "ENSG00000140391" "TSPAN3" "A6NEH4; B3KQQ2; B4DP19; hsa:10099; O60637; Q9BW22; Q9NVX9" "" "" "0" "0" "1.088" "1.063" "1.086" "1.160" "1.102" "1.013" "1.072" "0.996" "0.640" "219.6" "239.0" "233.5" "238.5" "254.7" "242.0" "222.4" "235.4" "218.8" "140.5" "" "" "" "" "" "" "" "" "" "" "131.4" "124.2" "129.3" "112.0" "118.1" "123.9" "103.4" "105.7" "118.7" "140.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7407446589588264140" "False" "High" "IsMasterProtein" "O94763" "Unconventional prefoldin RPB5 interactor 1 OS=Homo sapiens OX=9606 GN=URI1 PE=1 SV=3" "0.000" "False" "4.383" "4" "2" "2" "2" "535" "59.8" "5.05" "4.21" "2" "other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02996" "8725" "ENSG00000105176" "URI1" "A8K805; H7BY42; hsa:8725; O94763; Q8TC23; Q9UNU3" "" "" "0" "0" "0.901" "0.727" "0.824" "1.201" "0.898" "0.895" "0.740" "1.187" "1.188" "35.9" "32.3" "26.1" "29.6" "43.1" "32.2" "32.1" "26.5" "42.6" "42.6" "" "" "" "" "" "" "" "" "" "" "21.5" "16.8" "14.4" "13.9" "20.0" "16.5" "14.9" "11.9" "23.1" "42.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-705908850981217680" "False" "High" "IsMasterProtein" "Q9NWZ5" "Uridine-cytidine kinase-like 1 OS=Homo sapiens OX=9606 GN=UCKL1 PE=1 SV=2" "0.000" "False" "4.376" "3" "2" "2" "2" "548" "61.1" "7.36" "2.28" "2" "other metabolic processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00485, Pf14681" "54963" "ENSG00000198276" "UCKL1" "B7Z8N2; hsa:54963; Q5JWV0; Q70AQ5; Q8N524; Q9H3Z2; Q9NWZ5" "Pyrimidine metabolism" "Pyrimidine salvage" "2" "0" "0.800" "0.764" "0.809" "1.095" "0.883" "1.147" "0.878" "0.973" "1.293" "88.2" "70.6" "67.4" "71.4" "96.5" "77.8" "101.1" "77.4" "85.8" "114.0" "" "" "" "" "" "" "" "" "" "" "52.8" "36.7" "37.3" "33.5" "44.7" "39.8" "47.0" "34.8" "46.6" "114.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2076533743620825156" "False" "High" "IsMasterProtein" "Q02080" "Myocyte-specific enhancer factor 2B OS=Homo sapiens OX=9606 GN=MEF2B PE=1 SV=2" "0.000" "False" "4.375" "3" "1" "1" "1" "365" "38.6" "9.48" "3.55" "1" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319" "100271849; 4207" "ENSG00000213999" "MEF2B" "A0AV80; B4DVH7; B7ZVY1; G5E9M1; hsa:100271849; hsa:4207; Q02080" "Energy metabolism; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; Adipogenesis; Gastrin signaling pathway" "Myogenesis" "7" "0" "0.874" "0.918" "0.823" "1.270" "0.785" "0.968" "0.747" "0.909" "2.994" "21.0" "18.3" "19.3" "17.3" "26.7" "16.5" "20.3" "15.7" "19.1" "62.8" "" "" "" "" "" "" "" "" "" "" "12.6" "9.5" "10.7" "8.1" "12.4" "8.4" "9.4" "7.0" "10.3" "62.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4204109305997435954" "False" "High" "IsMasterProtein" "Q07960" "Rho GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=ARHGAP1 PE=1 SV=1" "0.000" "False" "4.374" "5" "2" "2" "2" "439" "50.4" "6.29" "2.27" "2" "transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00620, Pf13716" "392" "ENSG00000175220" "ARHGAP1" "D3DQQ6; hsa:392; Q07960" "" "RHOC GTPase cycle; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2260332764015544813" "False" "High" "IsMasterProtein" "Q9BTW9" "Tubulin-specific chaperone D OS=Homo sapiens OX=9606 GN=TBCD PE=1 SV=2" "0.000" "False" "4.373" "1" "1" "1" "1" "1192" "132.5" "6.19" "2.64" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf12612" "6904" "ENSG00000141556" "TBCD" "hsa:6904; O95458; Q7L8K1; Q8IXP6; Q8NAX0; Q8WYH4; Q96E74; Q9BTW9; Q9UF82; Q9UG46; Q9Y2J3" "" "Post-chaperonin tubulin folding pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1054050603788689952" "False" "High" "IsMasterProtein" "Q86YV0" "RAS protein activator like-3 OS=Homo sapiens OX=9606 GN=RASAL3 PE=1 SV=2" "0.000" "False" "4.366" "1" "1" "1" "1" "1011" "111.8" "8.75" "3.12" "1" "other biological processes" "other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00616" "64926" "ENSG00000105122" "RASAL3" "hsa:64926; Q86YV0; Q8N2T9; Q9H735" "Ras signaling" "Regulation of RAS by GAPs" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "Not Found" "High" "High" "High" "High" "High" "High" "1" "" "7583524308725557668" "False" "High" "IsMasterProtein" "Q96J01" "THO complex subunit 3 OS=Homo sapiens OX=9606 GN=THOC3 PE=1 SV=1" "0.000" "False" "4.354" "5" "2" "3" "2" "351" "38.7" "6.09" "6.01" "2" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00400, Pf07676, Pf12894" "84321" "ENSG00000051596" "THOC3" "hsa:84321; Q6NZ53; Q96J01" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "1.020" "0.986" "0.976" "1.086" "1.126" "0.885" "0.922" "1.045" "1.427" "228.2" "232.8" "225.0" "222.7" "247.9" "257.0" "202.0" "210.4" "238.4" "325.6" "" "" "" "" "" "" "" "" "" "" "136.5" "121.0" "124.6" "104.6" "114.9" "131.6" "93.9" "94.5" "129.3" "325.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5064589920710455811" "False" "High" "IsMasterProtein" "O00635" "E3 ubiquitin-protein ligase TRIM38 OS=Homo sapiens OX=9606 GN=TRIM38 PE=1 SV=1" "0.000" "False" "4.353" "4" "2" "2" "2" "465" "53.4" "7.02" "1.63" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13765, Pf15227" "10475" "ENSG00000112343" "TRIM38" "B2R862; hsa:10475; O00635" "" "Interferon gamma signaling" "1" "0" "1.365" "1.116" "1.086" "1.225" "1.223" "0.978" "0.010" "1.004" "13.638" "6.2" "8.4" "6.9" "6.7" "7.5" "7.5" "6.0" "0.0" "6.2" "84.0" "" "" "" "" "" "" "" "" "" "" "3.7" "4.4" "3.8" "3.1" "3.5" "3.9" "2.8" "0.0" "3.4" "84.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3899808669823360054" "False" "High" "IsMasterProtein" "Q9Y2U8" "Inner nuclear membrane protein Man1 OS=Homo sapiens OX=9606 GN=LEMD3 PE=1 SV=2" "0.000" "False" "4.342" "5" "2" "2" "2" "911" "99.9" "7.55" "0.00" "2" "other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf03020, Pf09402" "23592" "ENSG00000174106" "LEMD3" "hsa:23592; Q9NT47; Q9NYA5; Q9Y2U8" "Envelope proteins and their potential roles in EDMD physiopathology" "RND2 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "Not Found" "High" "High" "High" "1" "" "-3589965409300637784" "False" "High" "IsMasterProtein" "Q14691" "DNA replication complex GINS protein PSF1 OS=Homo sapiens OX=9606 GN=GINS1 PE=1 SV=1" "0.000" "False" "4.341" "9" "2" "2" "2" "196" "23.0" "7.39" "2.73" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes" "nucleus;other cell component" "" "Pf05916" "9837" "ENSG00000101003" "GINS1" "hsa:9837; Q14691; Q9NQE2; Q9NQI7" "" "Unwinding of DNA" "1" "0" "1.149" "1.007" "1.030" "1.119" "1.050" "0.834" "0.942" "0.989" "1.607" "115.8" "133.0" "116.6" "119.3" "129.6" "121.6" "96.6" "109.1" "114.5" "186.2" "" "" "" "" "" "" "" "" "" "" "69.3" "69.1" "64.6" "56.0" "60.1" "62.2" "44.9" "49.0" "62.1" "186.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1217217274349295091" "False" "High" "IsMasterProtein" "Q9Y4E8" "Ubiquitin carboxyl-terminal hydrolase 15 OS=Homo sapiens OX=9606 GN=USP15 PE=1 SV=3" "0.000" "False" "4.333" "2" "2" "2" "2" "981" "112.3" "5.22" "1.83" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00443, Pf06337, Pf14533, Pf14836" "9958" "ENSG00000135655" "USP15" "hsa:9958; Q08AL5; Q9H8G9; Q9HCA6; Q9UNP0; Q9Y4E8; Q9Y5B5" "" "UCH proteinases; Ub-specific processing proteases; Downregulation of TGF-beta receptor signaling" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4219913778501772025" "False" "High" "IsMasterProtein" "Q96PE7" "Methylmalonyl-CoA epimerase, mitochondrial OS=Homo sapiens OX=9606 GN=MCEE PE=1 SV=1" "0.000" "False" "4.331" "11" "2" "3" "2" "176" "18.7" "9.09" "6.82" "2" "other metabolic processes" "mitochondrion" "other molecular function" "Pf13669" "84693" "ENSG00000124370" "MCEE" "hsa:84693; Q53TP1; Q8WW63; Q96PE7" "Vitamin B12 metabolism" "Propionyl-CoA catabolism" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8654613729152941586" "False" "High" "IsMasterProtein" "P23786" "Carnitine O-palmitoyltransferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=CPT2 PE=1 SV=2" "0.000" "False" "4.328" "2" "2" "3" "2" "658" "73.7" "8.18" "4.39" "2" "other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00755" "1376" "ENSG00000157184" "CPT2" "B2R6S0; hsa:1376; P23786; Q5SW68; Q9BQ26" "Fatty acid beta-oxidation; PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Thermogenesis; Mitochondrial fatty acid oxidation disorders" "PPARA activates gene expression; Carnitine metabolism" "9" "0" "1.132" "1.224" "1.118" "1.786" "1.239" "1.281" "0.915" "1.171" "4.848" "33.4" "37.9" "40.9" "37.4" "59.7" "41.4" "42.8" "30.6" "39.2" "162.1" "" "" "" "" "" "" "" "" "" "" "20.0" "19.7" "22.7" "17.6" "27.7" "21.2" "19.9" "13.7" "21.2" "162.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8410241835469765050" "False" "High" "IsMasterProtein" "Q9Y2G2" "Caspase recruitment domain-containing protein 8 OS=Homo sapiens OX=9606 GN=CARD8 PE=1 SV=2" "0.000" "False" "4.325" "2" "1" "1" "1" "537" "60.6" "4.84" "3.25" "1" "cell organization and biogenesis;protein metabolism;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf13553" "22900" "ENSG00000105483" "CARD8" "B5KVR6; B5KVR8; B7Z496; B7Z4A2; E5RFV9; E9PEM7; G3XAM9; hsa:22900; Q6PGP8; Q96P82; Q9Y2G2" "Nucleotide-binding oligomerization domain (NOD) pathway" "Regulation of the apoptosome activity" "3" "0" "1.177" "0.999" "1.230" "0.965" "1.149" "0.930" "1.154" "0.900" "0.614" "40.0" "47.0" "39.9" "49.1" "38.6" "45.9" "37.2" "46.1" "36.0" "24.5" "" "" "" "" "" "" "" "" "" "" "23.9" "24.4" "22.1" "23.1" "17.9" "23.5" "17.3" "20.7" "19.5" "24.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-949132700508493695" "False" "High" "IsMasterProtein" "Q8WW59" "SPRY domain-containing protein 4 OS=Homo sapiens OX=9606 GN=SPRYD4 PE=1 SV=3" "0.000" "False" "4.319" "12" "2" "2" "2" "207" "23.1" "6.93" "1.71" "2" "" "nucleus" "" "Pf00622" "283377" "ENSG00000176422" "SPRYD4" "A8K7A5; hsa:283377; Q8WW59" "" "" "0" "0" "0.874" "0.720" "1.209" "0.861" "0.976" "0.769" "0.930" "1.025" "1.095" "40.7" "35.6" "29.3" "49.2" "35.0" "39.7" "31.3" "37.8" "41.7" "44.6" "" "" "" "" "" "" "" "" "" "" "24.3" "18.5" "16.2" "23.1" "16.2" "20.3" "14.6" "17.0" "22.6" "44.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "75736922320642282" "False" "High" "IsMasterProtein" "O95568" "Histidine protein methyltransferase 1 homolog OS=Homo sapiens OX=9606 GN=METTL18 PE=1 SV=1" "0.000" "False" "4.318" "6" "1" "1" "1" "372" "42.1" "6.76" "3.11" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13489" "92342" "ENSG00000171806" "METTL18" "B2R9T5; hsa:92342; O95568" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "Not Found" "High" "High" "High" "1" "" "-8740975055967109676" "False" "High" "IsMasterProtein" "O95926" "Pre-mRNA-splicing factor SYF2 OS=Homo sapiens OX=9606 GN=SYF2 PE=1 SV=1" "0.000" "False" "4.318" "5" "1" "1" "1" "243" "28.7" "8.40" "4.15" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf08231" "25949" "ENSG00000117614" "SYF2" "hsa:25949; O95926; Q5TH73" "" "mRNA Splicing - Major Pathway" "1" "0" "0.605" "0.568" "0.569" "0.519" "0.528" "0.599" "0.662" "0.621" "0.235" "211.5" "128.0" "120.2" "120.4" "109.7" "111.7" "126.6" "140.0" "131.5" "49.6" "" "" "" "" "" "" "" "" "" "" "126.6" "66.5" "66.6" "56.5" "50.9" "57.2" "58.9" "62.8" "71.3" "49.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "967030651674579734" "False" "High" "IsMasterProtein" "Q9NV88" "Integrator complex subunit 9 OS=Homo sapiens OX=9606 GN=INTS9 PE=1 SV=2" "0.000" "False" "4.318" "3" "2" "2" "2" "658" "73.8" "6.33" "4.22" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf10996, Pf16661, Pf21382" "55756" "ENSG00000104299" "INTS9" "B7Z560; B7Z6M5; hsa:55756; O00224; Q8TB16; Q9NV88" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.080" "0.968" "1.271" "1.043" "1.156" "1.160" "1.239" "1.254" "0.876" "41.9" "45.3" "40.6" "53.3" "43.7" "48.5" "48.7" "52.0" "52.6" "36.8" "" "" "" "" "" "" "" "" "" "" "25.1" "23.5" "22.5" "25.0" "20.3" "24.8" "22.6" "23.3" "28.5" "36.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8637323044109722120" "False" "High" "IsMasterProtein" "Q2NKX8" "DNA excision repair protein ERCC-6-like OS=Homo sapiens OX=9606 GN=ERCC6L PE=1 SV=1" "0.000" "False" "4.306" "1" "1" "1" "1" "1250" "141.0" "5.31" "2.65" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "54821" "ENSG00000186871" "ERCC6L" "hsa:54821; Q2NKX8; Q8NCI1; Q96H93; Q9NXQ8" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4412599355076663570" "False" "High" "IsMasterProtein" "Q8WV92" "MIT domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MITD1 PE=1 SV=1" "0.000" "False" "4.301" "4" "1" "1" "1" "249" "29.3" "8.00" "3.56" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04212, Pf16565" "129531" "ENSG00000158411" "MITD1" "hsa:129531; Q69YV0; Q8WV92" "TAR syndrome" "" "1" "0" "0.988" "0.840" "1.053" "1.044" "1.068" "1.090" "1.182" "1.046" "0.972" "111.1" "109.8" "93.4" "117.0" "116.0" "118.7" "121.1" "131.4" "116.2" "108.0" "" "" "" "" "" "" "" "" "" "" "66.5" "57.1" "51.7" "54.9" "53.8" "60.8" "56.3" "59.0" "63.0" "108.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5029706333006790084" "False" "High" "IsMasterProtein" "Q5VT52" "Regulation of nuclear pre-mRNA domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RPRD2 PE=1 SV=1" "0.000" "False" "4.295" "2" "2" "2" "2" "1461" "155.9" "7.42" "1.77" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04818" "23248" "ENSG00000163125" "RPRD2" "A8K6N8; B3KPT1; B4E2Q6; hsa:23248; O75048; Q5VT51; Q5VT52; Q5VT53; Q6MZL4; Q86XD2; Q9P0D7" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4179257016855703776" "False" "High" "IsMasterProtein" "Q53QV2" "Protein LBH OS=Homo sapiens OX=9606 GN=LBH PE=1 SV=1" "0.000" "False" "4.292" "20" "1" "1" "1" "105" "12.2" "4.41" "3.04" "1" "other biological processes" "nucleus;other cell component" "" "Pf15317" "81606" "ENSG00000213626" "LBH" "B2RBC2; hsa:81606; Q53QV2; Q9H0Q1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5308082143838358470" "False" "High" "IsMasterProtein" "P42766" "Large ribosomal subunit protein uL29 OS=Homo sapiens OX=9606 GN=RPL35 PE=1 SV=2" "0.000" "False" "4.284" "13" "2" "2" "2" "123" "14.5" "11.05" "4.31" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00831" "11224" "ENSG00000136942" "RPL35" "A8K4V7; hsa:11224; P42766; Q4VBY5; Q5JTN5; Q6IBC7; Q96QJ7; Q9BYF4" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.753" "1.054" "0.881" "1.462" "0.988" "0.918" "0.790" "1.156" "1.418" "27.0" "20.3" "28.4" "23.8" "39.4" "26.7" "24.8" "21.3" "31.2" "38.3" "" "" "" "" "" "" "" "" "" "" "16.1" "10.6" "15.7" "11.2" "18.3" "13.6" "11.5" "9.6" "16.9" "38.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6571071577836756123" "False" "High" "IsMasterProtein" "Q9NUP1" "Biogenesis of lysosome-related organelles complex 1 subunit 4 OS=Homo sapiens OX=9606 GN=BLOC1S4 PE=1 SV=1" "0.000" "False" "4.283" "5" "1" "1" "1" "217" "23.3" "4.98" "3.35" "1" "cell adhesion;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "cytosol;other cell component" "" "" "55330" "ENSG00000186222" "BLOC1S4" "hsa:55330; Q6NVY6; Q96G84; Q9NUP1" "Alstrom syndrome" "Golgi Associated Vesicle Biogenesis" "2" "0" "1.380" "1.034" "0.970" "1.446" "1.262" "1.505" "1.270" "1.249" "1.303" "50.4" "69.5" "52.1" "48.9" "72.8" "63.6" "75.8" "64.0" "62.9" "65.6" "" "" "" "" "" "" "" "" "" "" "30.2" "36.1" "28.8" "22.9" "33.8" "32.6" "35.3" "28.7" "34.2" "65.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6043463436452304537" "False" "High" "IsMasterProtein" "Q5SSJ5" "Heterochromatin protein 1-binding protein 3 OS=Homo sapiens OX=9606 GN=HP1BP3 PE=1 SV=1" "0.000" "False" "4.282" "4" "2" "2" "2" "553" "61.2" "9.67" "1.81" "2" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "50809" "ENSG00000127483" "HP1BP3" "A6NI71; A8K5D7; B3KMZ8; B4E210; hsa:50809; Q05BI0; Q5SSJ5; Q5SSJ6; Q5SWC6; Q6PIM9; Q8NDF0; Q9UHY0" "" "" "0" "0" "1.087" "1.053" "1.181" "1.171" "1.173" "1.194" "1.077" "0.973" "0.952" "107.4" "116.8" "113.1" "126.8" "125.8" "126.0" "128.3" "115.7" "104.5" "102.3" "" "" "" "" "" "" "" "" "" "" "64.3" "60.7" "62.6" "59.5" "58.3" "64.5" "59.7" "51.9" "56.7" "102.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9153241618277291639" "False" "High" "IsMasterProtein" "Q9ULK4" "Mediator of RNA polymerase II transcription subunit 23 OS=Homo sapiens OX=9606 GN=MED23 PE=1 SV=2" "0.000" "False" "4.279" "1" "2" "2" "2" "1368" "156.4" "7.40" "4.45" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11573" "9439" "ENSG00000112282" "MED23" "B9TX55; hsa:9439; O95403; Q5JWT3; Q5JWT4; Q6P9H6; Q9H0J2; Q9NTT9; Q9NTU0; Q9ULK4; Q9Y5P7; Q9Y667" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "0.703" "0.858" "0.890" "1.082" "1.065" "0.961" "0.917" "0.812" "1.825" "74.3" "52.2" "63.8" "66.1" "80.4" "79.1" "71.4" "68.1" "60.3" "135.6" "" "" "" "" "" "" "" "" "" "" "44.5" "27.1" "35.3" "31.0" "37.2" "40.5" "33.2" "30.6" "32.7" "135.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "57787487465406304" "False" "High" "IsMasterProtein" "Q08945" "FACT complex subunit SSRP1 OS=Homo sapiens OX=9606 GN=SSRP1 PE=1 SV=1" "0.000" "False" "4.269" "2" "1" "1" "1" "709" "81.0" "6.87" "3.44" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505, Pf03531, Pf08512, Pf17292, Pf21092, Pf21103" "6749" "ENSG00000149136" "SSRP1" "hsa:6749; Q08945; Q5BJG8" "" "Regulation of TP53 Activity through Phosphorylation; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "12" "0" "1.333" "1.389" "1.054" "0.942" "0.889" "1.128" "1.266" "1.137" "0.727" "30.9" "41.2" "42.9" "32.6" "29.1" "27.5" "34.9" "39.1" "35.1" "22.5" "" "" "" "" "" "" "" "" "" "" "18.5" "21.4" "23.8" "15.3" "13.5" "14.1" "16.2" "17.6" "19.1" "22.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1941852327752543049" "False" "High" "IsMasterProtein" "Q93009" "Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens OX=9606 GN=USP7 PE=1 SV=2" "0.000" "False" "4.250" "1" "2" "2" "2" "1102" "128.2" "5.55" "1.93" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf00917, Pf12436, Pf14533" "7874" "ENSG00000187555" "USP7" "A6NMY8; B7Z815; H0Y3G8; hsa:7874; Q93009" "Nucleotide excision repair in xeroderma pigmentosum ; Warburg effect modulated by deubiquitinating enzymes and their substrates" "Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Ub-specific processing proteases; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Regulation of TP53 Degradation; Formation of TC-NER Pre-Incision Complex; Regulation of PTEN localization" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1560013588739463450" "False" "High" "IsMasterProtein" "Q9H7D7" "WD repeat-containing protein 26 OS=Homo sapiens OX=9606 GN=WDR26 PE=1 SV=3" "0.000" "False" "4.250" "3" "2" "2" "2" "661" "72.1" "6.16" "4.22" "2" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf00400, Pf17814" "80232" "ENSG00000162923" "WDR26" "A0MNN3; hsa:80232; Q4G100; Q59EC4; Q5GLZ9; Q86UY4; Q9H3C2; Q9H7D7" "Ciliary landscape" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1759740052719989179" "False" "High" "IsMasterProtein" "O14561" "Acyl carrier protein, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAB1 PE=1 SV=3" "0.000" "False" "4.244" "10" "2" "14" "2" "156" "17.4" "4.93" "34.98" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;nucleus" "translation activity;other molecular function" "Pf00550" "4706" "ENSG00000004779" "NDUFAB1" "B2R4M1; O14561; Q9UNV1" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Glyoxylate metabolism and glycine degradation; Mitochondrial Fatty Acid Beta-Oxidation; Complex I biogenesis" "7" "0" "1.018" "1.006" "1.000" "1.189" "1.094" "1.110" "1.242" "1.083" "0.579" "1118.1" "1138.2" "1124.4" "1118.3" "1329.4" "1223.7" "1241.1" "1388.7" "1210.4" "647.9" "" "" "" "" "" "" "" "" "" "" "669.1" "591.5" "622.7" "525.0" "616.2" "626.5" "577.1" "623.4" "656.7" "647.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8437965729251271503" "False" "High" "IsMasterProtein" "Q969P0" "Immunoglobulin superfamily member 8 OS=Homo sapiens OX=9606 GN=IGSF8 PE=1 SV=1" "0.000" "False" "4.234" "3" "1" "1" "1" "613" "65.0" "8.00" "2.76" "1" "developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf07686" "93185" "ENSG00000162729" "IGSF8" "hsa:93185; Q8NG09; Q969P0; Q96DP4; Q9BTG9" "11p11.2 copy number variation syndrome" "" "1" "0" "1.448" "1.934" "1.581" "1.019" "0.530" "0.601" "0.691" "0.675" "0.398" "24.1" "35.0" "46.7" "38.2" "24.6" "12.8" "14.5" "16.7" "16.3" "9.6" "" "" "" "" "" "" "" "" "" "" "14.5" "18.2" "25.9" "17.9" "11.4" "6.6" "6.7" "7.5" "8.8" "9.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "697873925504819237" "False" "High" "IsMasterProtein" "P50053" "Ketohexokinase OS=Homo sapiens OX=9606 GN=KHK PE=1 SV=2" "0.000" "False" "4.214" "5" "2" "2" "2" "298" "32.5" "6.32" "4.72" "2" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00294" "3795" "ENSG00000138030" "KHK" "hsa:3795; P50053; Q6IBK2; Q99532; Q9BRJ3; Q9UMN1" "Disorders of fructose metabolism; Polyol pathway" "Fructose catabolism; Essential fructosuria" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3318152306764108447" "False" "High" "IsMasterProtein" "O60563" "Cyclin-T1 OS=Homo sapiens OX=9606 GN=CCNT1 PE=1 SV=1" "0.000" "False" "4.212" "2" "2" "2" "2" "726" "80.6" "8.78" "4.71" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00134, Pf21797" "904" "ENSG00000129315" "CCNT1" "A9XU13; E7EX76; hsa:904; O60563; O60581" "Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins" "17" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4265990204774033592" "False" "High" "IsMasterProtein" "O75175" "CCR4-NOT transcription complex subunit 3 OS=Homo sapiens OX=9606 GN=CNOT3 PE=1 SV=1" "0.000" "False" "4.208" "3" "2" "2" "2" "753" "81.8" "6.20" "2.68" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04065, Pf04153" "4849" "ENSG00000088038; ENSG00000273943; ENSG00000274176; ENSG00000274616; ENSG00000274941; ENSG00000275979; ENSG00000276082; ENSG00000277114; ENSG00000277600; ENSG00000277615" "CNOT3" "hsa:4849; O75175; Q9NZN7; Q9UF76" "" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "1.041" "0.983" "1.116" "1.172" "1.036" "1.082" "1.063" "1.124" "1.486" "187.4" "195.1" "184.3" "209.1" "219.6" "194.2" "202.7" "199.1" "210.7" "278.6" "" "" "" "" "" "" "" "" "" "" "112.2" "101.4" "102.1" "98.2" "101.8" "99.4" "94.3" "89.4" "114.3" "278.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9120565565592818035" "False" "High" "IsMasterProtein" "P23443" "Ribosomal protein S6 kinase beta-1 OS=Homo sapiens OX=9606 GN=RPS6KB1 PE=1 SV=2" "0.000" "False" "4.205" "2" "1" "1" "1" "525" "59.1" "6.65" "3.68" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433" "6198" "ENSG00000108443" "RPS6KB1" "B2R779; B4DLT4; B4DTG1; E7ESB8; F6UYM1; hsa:6198; P23443; Q7Z721" "IL-5 signaling pathway; AMP-activated protein kinase signaling; Target of rapamycin signaling; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Kit receptor signaling pathway; IL6 signaling pathway; BDNF-TrkB signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PI3K-Akt signaling pathway; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Thermogenesis; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; GDNF signaling; G13 signaling pathway; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways; ErbB signaling pathway" "mTORC1-mediated signalling" "42" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-909250529717419183" "False" "High" "IsMasterProtein" "P26447" "Protein S100-A4 OS=Homo sapiens OX=9606 GN=S100A4 PE=1 SV=1" "0.000" "False" "4.195" "17" "2" "2" "2" "101" "11.7" "6.11" "4.84" "2" "signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf01023" "6275" "ENSG00000196154" "S100A4" "A8K7R8; D3DV46; hsa:6275; P26447; Q6ICP8" "Vitamin D receptor pathway" "" "1" "0" "1.066" "0.868" "1.194" "1.185" "1.037" "1.096" "1.237" "1.054" "0.962" "76.3" "81.3" "66.2" "91.1" "90.4" "79.1" "83.6" "94.4" "80.4" "73.4" "" "" "" "" "" "" "" "" "" "" "45.7" "42.3" "36.7" "42.8" "41.9" "40.5" "38.9" "42.4" "43.6" "73.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2510158146736873084" "False" "High" "IsMasterProtein" "P29084" "Transcription initiation factor IIE subunit beta OS=Homo sapiens OX=9606 GN=GTF2E2 PE=1 SV=1" "0.000" "False" "4.187" "6" "2" "2" "2" "291" "33.0" "9.66" "4.57" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf02186, Pf18121" "2961" "ENSG00000197265" "GTF2E2" "D3DSV2; P29084; Q9H2B9" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6354667477089484627" "False" "High" "IsMasterProtein" "Q5T2E6" "Armadillo-like helical domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ARMH3 PE=1 SV=1" "0.000" "False" "4.182" "1" "1" "1" "1" "689" "78.7" "6.60" "3.42" "1" "other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf08427" "79591" "ENSG00000120029" "ARMH3" "hsa:79591; Q2TB87; Q5T2E6; Q9H8Z9" "" "" "0" "0" "1.048" "0.835" "0.978" "1.305" "1.027" "1.201" "1.016" "1.071" "0.691" "83.8" "87.8" "70.0" "81.9" "109.3" "86.1" "100.7" "85.2" "89.8" "57.9" "" "" "" "" "" "" "" "" "" "" "50.1" "45.6" "38.7" "38.5" "50.7" "44.1" "46.8" "38.2" "48.7" "57.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8165870367093882655" "False" "High" "IsMasterProtein" "Q86TI2" "Dipeptidyl peptidase 9 OS=Homo sapiens OX=9606 GN=DPP9 PE=1 SV=3" "0.000" "False" "4.181" "2" "2" "2" "2" "863" "98.2" "6.46" "4.65" "2" "protein metabolism;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00326, Pf00930, Pf19520" "91039" "ENSG00000142002" "DPP9" "hsa:91039; O75273; O75868; Q1ZZB8; Q6AI37; Q6UAL0; Q6ZMT2; Q6ZNJ5; Q86TI2; Q8N2J7; Q8N3F5; Q8WXD8; Q96NT8; Q9BVR3" "Lung fibrosis" "" "1" "0" "0.796" "0.857" "0.919" "1.036" "1.023" "0.876" "0.606" "0.983" "5.274" "66.9" "53.2" "57.3" "61.5" "69.3" "68.4" "58.6" "40.6" "65.8" "352.9" "" "" "" "" "" "" "" "" "" "" "40.0" "27.7" "31.7" "28.9" "32.1" "35.0" "27.3" "18.2" "35.7" "352.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8333462526308289964" "False" "High" "IsMasterProtein" "O60671" "Cell cycle checkpoint protein RAD1 OS=Homo sapiens OX=9606 GN=RAD1 PE=1 SV=1" "0.000" "False" "4.178" "5" "2" "2" "2" "282" "31.8" "4.83" "5.42" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02144" "5810" "ENSG00000113456" "RAD1" "hsa:5810; O60671; O75572; O95304; Q1W161; Q5KSM0; Q5KSM1; Q9UEP1" "miRNA regulation of DNA damage response; ATR signaling; DNA damage response" "Presynaptic phase of homologous DNA pairing and strand exchange; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "10" "0" "0.995" "1.046" "1.184" "1.113" "1.164" "1.046" "1.181" "1.096" "0.916" "99.8" "99.4" "104.5" "118.2" "111.1" "116.2" "104.4" "117.9" "109.4" "91.4" "" "" "" "" "" "" "" "" "" "" "59.8" "51.6" "57.8" "55.5" "51.5" "59.5" "48.5" "52.9" "59.4" "91.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9157929292758815644" "False" "High" "IsMasterProtein" "Q96A35" "Large ribosomal subunit protein uL24m OS=Homo sapiens OX=9606 GN=MRPL24 PE=1 SV=1" "0.000" "False" "4.178" "5" "1" "1" "1" "216" "24.9" "9.29" "2.99" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00467, Pf17136" "79590" "ENSG00000143314" "MRPL24" "D3DVC8; hsa:79590; Q53G65; Q53HT0; Q5SYZ9; Q5SZ00; Q5SZ02; Q96A35; Q96Q70; Q9H7G3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.837" "3.136" "0.869" "0.805" "0.858" "0.803" "0.746" "1.216" "3.030" "45.9" "38.4" "144.1" "39.9" "37.0" "39.4" "36.9" "34.3" "55.9" "139.2" "" "" "" "" "" "" "" "" "" "" "27.5" "20.0" "79.8" "18.7" "17.2" "20.2" "17.2" "15.4" "30.3" "139.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "882715983706929749" "False" "High" "IsMasterProtein" "Q9NZ08" "Endoplasmic reticulum aminopeptidase 1 OS=Homo sapiens OX=9606 GN=ERAP1 PE=1 SV=3" "0.000" "False" "4.172" "1" "1" "1" "1" "941" "107.2" "6.46" "2.70" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01433, Pf11838, Pf17900" "51752" "ENSG00000164307" "ERAP1" "hsa:51752; O60278; Q6UWY6; Q8NEL4; Q8TAD0; Q9NZ08; Q9UHF8; Q9UKY2" "" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "1" "0" "0.814" "1.442" "0.851" "1.047" "1.125" "0.796" "1.433" "0.979" "2.416" "28.9" "23.6" "41.7" "24.6" "30.3" "32.6" "23.1" "41.5" "28.3" "69.9" "" "" "" "" "" "" "" "" "" "" "17.3" "12.2" "23.1" "11.6" "14.0" "16.7" "10.7" "18.6" "15.4" "69.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4255183124898333384" "False" "High" "IsMasterProtein" "Q9Y6G5" "COMM domain-containing protein 10 OS=Homo sapiens OX=9606 GN=COMMD10 PE=1 SV=1" "0.000" "False" "4.161" "6" "1" "1" "1" "202" "23.0" "6.54" "2.65" "1" "" "nucleus;other cell component" "" "Pf07258, Pf21672" "51397" "ENSG00000145781" "COMMD10" "D3DT07; hsa:51397; Q9P077; Q9Y6G5" "" "Neddylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2546736599525709996" "False" "High" "IsMasterProtein" "Q8N1G2" "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=CMTR1 PE=1 SV=1" "0.000" "False" "4.152" "1" "1" "1" "1" "835" "95.3" "7.05" "2.61" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01585, Pf01728" "23070" "ENSG00000137200" "CMTR1" "A8K949; hsa:23070; Q14670; Q8N1G2; Q96FJ9" "" "" "0" "0" "1.046" "1.121" "1.419" "1.344" "1.047" "1.253" "0.804" "1.090" "3.694" "45.6" "47.8" "51.2" "64.8" "61.4" "47.8" "57.2" "36.7" "49.7" "168.6" "" "" "" "" "" "" "" "" "" "" "27.3" "24.8" "28.3" "30.4" "28.4" "24.5" "26.6" "16.5" "27.0" "168.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3725615404801325538" "False" "High" "IsMasterProtein" "Q9UJX3" "Anaphase-promoting complex subunit 7 OS=Homo sapiens OX=9606 GN=ANAPC7 PE=1 SV=5" "0.000" "False" "4.151" "3" "1" "3" "1" "565" "63.1" "5.72" "7.23" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf13181" "" "ENSG00000196510" "ANAPC7" "Q96AC4; Q96GF4; Q9BU24; Q9NT16; Q9UJX3" "Cell cycle" "Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Inactivation of APC/C via direct inhibition of the APC/C complex; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "1.123" "0.948" "1.098" "1.225" "1.073" "1.190" "1.126" "0.926" "0.744" "70.9" "79.6" "67.2" "77.8" "86.8" "76.1" "84.4" "79.8" "65.6" "52.7" "" "" "" "" "" "" "" "" "" "" "42.4" "41.4" "37.2" "36.5" "40.2" "39.0" "39.2" "35.8" "35.6" "52.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2934429115890705699" "False" "High" "IsMasterProtein" "P49821" "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV1 PE=1 SV=4" "0.000" "False" "4.138" "2" "1" "1" "1" "464" "50.8" "8.21" "3.02" "1" "other metabolic processes;transport" "other membranes;cytosol;mitochondrion" "transporter activity;other molecular function" "Pf01512, Pf10589" "4723" "ENSG00000167792" "NDUFV1" "hsa:4723; O60924; O60940; P49821; Q16104; Q6IBR3; Q96BF8; Q96HS7" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; HDAC6 interactions in the central nervous system; Oxidative phosphorylation" "Complex I biogenesis; Mitochondrial protein degradation" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3529380218292263569" "False" "High" "IsMasterProtein" "P05423" "DNA-directed RNA polymerase III subunit RPC4 OS=Homo sapiens OX=9606 GN=POLR3D PE=1 SV=2" "0.000" "False" "4.133" "3" "1" "1" "1" "398" "44.4" "6.98" "4.00" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05132" "661" "ENSG00000168495" "POLR3D" "hsa:661; P05423; Q6FI28; Q9BPV7; Q9BPZ1; Q9BXB3" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "1.164" "1.131" "1.178" "1.016" "1.109" "1.173" "1.087" "1.002" "1.248" "76.6" "89.2" "86.7" "90.3" "77.8" "85.0" "89.9" "83.3" "76.8" "95.7" "" "" "" "" "" "" "" "" "" "" "45.9" "46.4" "48.0" "42.4" "36.1" "43.5" "41.8" "37.4" "41.7" "95.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4335544546222164902" "False" "High" "IsMasterProtein" "Q9NRX4" "14 kDa phosphohistidine phosphatase OS=Homo sapiens OX=9606 GN=PHPT1 PE=1 SV=1" "0.000" "False" "4.131" "18" "2" "3" "2" "125" "13.8" "6.07" "1.93" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf05005" "29085" "ENSG00000054148" "PHPT1" "B1AMX0; B1AMX1; hsa:29085; Q9H0Y3; Q9NRX4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4479122024934742870" "False" "High" "IsMasterProtein" "Q92934" "Bcl2-associated agonist of cell death OS=Homo sapiens OX=9606 GN=BAD PE=1 SV=3" "0.000" "False" "4.127" "13" "1" "1" "1" "168" "18.4" "7.15" "3.02" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf10514" "572" "ENSG00000002330" "BAD" "hsa:572; O14803; Q6FH21; Q92934" "Leptin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Amyotrophic lateral sclerosis (ALS); Apoptosis; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Oxidative damage response; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; NO/cGMP/PKG mediated neuroprotection; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Non-small cell lung cancer; Pancreatic adenocarcinoma pathway; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Host-pathogen interaction of human coronaviruses - apoptosis; Alzheimer's disease; Acute myeloid leukemia; ErbB signaling pathway; DNA damage response (only ATM dependent)" "NRAGE signals death through JNK; Constitutive Signaling by AKT1 E17K in Cancer; AKT phosphorylates targets in the cytosol; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Activation of BAD and translocation to mitochondria" "42" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "High" "Not Found" "Not Found" "Not Found" "High" "Not Found" "High" "Not Found" "1" "" "1650974207865814862" "False" "High" "IsMasterProtein" "P04818" "Thymidylate synthase OS=Homo sapiens OX=9606 GN=TYMS PE=1 SV=3" "0.000" "False" "4.120" "5" "1" "1" "1" "313" "35.7" "7.01" "3.55" "1" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00303" "7298" "ENSG00000176890" "TYMS" "hsa:7298; P04818; Q8WYK3; Q8WYK4" "Fluoropyrimidine activity; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription" "9" "0" "1.797" "1.544" "1.291" "1.452" "1.082" "1.656" "1.416" "1.450" "2.815" "14.0" "25.2" "21.7" "18.1" "20.4" "15.2" "23.2" "19.9" "20.3" "39.5" "" "" "" "" "" "" "" "" "" "" "8.4" "13.1" "12.0" "8.5" "9.4" "7.8" "10.8" "8.9" "11.0" "39.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7610728054593455927" "False" "High" "IsMasterProtein" "Q86SZ2" "Trafficking protein particle complex subunit 6B OS=Homo sapiens OX=9606 GN=TRAPPC6B PE=1 SV=1" "0.000" "False" "4.120" "6" "1" "1" "1" "158" "18.0" "8.68" "2.99" "1" "cell organization and biogenesis;transport;developmental processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "122553" "ENSG00000182400" "TRAPPC6B" "B3KPS2; hsa:122553; Q5JPD6; Q86SZ2; Q86U35; Q86X35" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "0.882" "0.868" "0.976" "0.956" "0.946" "0.892" "0.949" "1.014" "0.633" "128.2" "113.0" "111.3" "125.1" "122.5" "121.2" "114.3" "121.7" "130.0" "81.1" "" "" "" "" "" "" "" "" "" "" "76.7" "58.7" "61.6" "58.7" "56.8" "62.0" "53.2" "54.6" "70.5" "81.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9180192453950737945" "False" "High" "IsMasterProtein" "A0PJW8" "Death-associated protein-like 1 OS=Homo sapiens OX=9606 GN=DAPL1 PE=1 SV=2" "0.000" "False" "4.111" "16" "2" "5" "2" "107" "11.9" "9.99" "8.61" "2" "stress response;signal transduction;other biological processes" "" "translation activity;other molecular function" "Pf15228" "92196" "ENSG00000163331" "DAPL1" "A0PJW8; A0PJW9; B9EIK6; hsa:92196" "" "" "0" "0" "1.004" "1.071" "1.022" "0.891" "1.015" "0.994" "1.033" "0.940" "0.555" "150.8" "151.4" "161.5" "154.1" "134.4" "153.0" "149.9" "155.8" "141.8" "83.7" "" "" "" "" "" "" "" "" "" "" "90.3" "78.7" "89.5" "72.4" "62.3" "78.3" "69.7" "70.0" "76.9" "83.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1244063578202926483" "False" "High" "IsMasterProtein" "Q68D10" "Protein SPT2 homolog OS=Homo sapiens OX=9606 GN=SPTY2D1 PE=1 SV=3" "0.000" "False" "4.106" "3" "2" "2" "2" "685" "75.6" "9.79" "2.40" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08243" "144108" "ENSG00000179119" "SPTY2D1" "hsa:144108; Q68D10; Q6AWA5; Q6MZI5; Q7Z390; Q7Z470; Q86VG8; Q8N3E7; Q8N417; Q8N8I3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5448927889689110920" "False" "High" "IsMasterProtein" "Q16539" "Mitogen-activated protein kinase 14 OS=Homo sapiens OX=9606 GN=MAPK14 PE=1 SV=3" "0.000" "False" "4.093" "6" "2" "5" "1" "360" "41.3" "5.78" "7.40" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1432" "ENSG00000112062" "MAPK14" "A6ZJ92; A8K6P4; B0LPH0; B5TY32; hsa:1432; O60776; Q13083; Q14084; Q16539; Q8TDX0" "Physiological and pathological hypertrophy of the heart; Angiogenesis; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; Alpha 6 beta 4 signaling pathway; Amyotrophic lateral sclerosis (ALS); Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; IL-4 signaling pathway; p38 MAPK signaling pathway; Oxidative stress response; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Regulatory circuits of the STAT3 signaling pathway; Leukocyte-intrinsic Hippo pathway functions; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; Pleural mesothelioma; Th17 cell differentiation pathway; GDNF signaling; Hippocampal synaptogenesis and neurogenesis; Comprehensive IL-17A signaling; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; IL-19 signaling pathway; Interferon type I signaling pathways; T-cell receptor signaling pathway; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Monoamine transport; Toll-like receptor signaling pathway" "Neutrophil degranulation; VEGFA-VEGFR2 Pathway; Regulation of TP53 Activity through Phosphorylation; DSCAM interactions; RHO GTPases Activate NADPH Oxidases; Myogenesis; ERK/MAPK targets; Oxidative Stress Induced Senescence; ADP signalling through P2Y purinoceptor 1; NOD1/2 Signaling Pathway; p38MAPK events; activated TAK1 mediates p38 MAPK activation; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; KSRP (KHSRP) binds and destabilizes mRNA; Activation of the AP-1 family of transcription factors; Platelet sensitization by LDL; CD163 mediating an anti-inflammatory response" "92" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4149430532130191750" "False" "High" "IsMasterProtein" "Q13057" "Bifunctional coenzyme A synthase OS=Homo sapiens OX=9606 GN=COASY PE=1 SV=4" "0.000" "False" "4.087" "2" "1" "1" "1" "564" "62.3" "6.99" "2.96" "1" "other metabolic processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf01121, Pf01467" "80347" "ENSG00000068120" "COASY" "B2RA78; B4DLU0; hsa:80347; Q13057; Q6GS23; Q8NBM7; Q8NEW1; Q8WXD4; Q9NRM3" "Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway" "Coenzyme A biosynthesis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-824304309308168891" "False" "High" "IsMasterProtein" "Q14005" "Pro-interleukin-16 OS=Homo sapiens OX=9606 GN=IL16 PE=1 SV=4" "0.000" "False" "4.084" "3" "2" "2" "2" "1332" "141.7" "8.06" "0.00" "2" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding" "Pf00595" "3603" "ENSG00000172349" "IL16" "A6NM20; A8MU65; B5TY35; B9EGR6; H3BVH5; hsa:3603; Q14005; Q16435; Q6VVE6; Q6ZMQ7; Q9UP18" "" "Other interleukin signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088218542987526353" "False" "High" "IsMasterProtein" "P49005" "DNA polymerase delta subunit 2 OS=Homo sapiens OX=9606 GN=POLD2 PE=1 SV=1" "0.000" "False" "4.084" "3" "1" "2" "1" "469" "51.3" "5.58" "1.89" "1" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity" "Pf04042, Pf18018" "5425" "ENSG00000106628" "POLD2" "A4D2J4; B2R5S4; hsa:5425; P49005" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "25" "0" "1.041" "1.336" "1.325" "1.477" "1.669" "0.944" "1.398" "1.069" "1.412" "27.5" "28.7" "36.8" "36.5" "40.6" "45.9" "26.0" "38.5" "29.4" "38.9" "" "" "" "" "" "" "" "" "" "" "16.5" "14.9" "20.4" "17.1" "18.8" "23.5" "12.1" "17.3" "16.0" "38.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3032211375385727038" "False" "High" "IsMasterProtein" "Q15388" "Mitochondrial import receptor subunit TOM20 homolog OS=Homo sapiens OX=9606 GN=TOMM20 PE=1 SV=1" "0.000" "False" "4.060" "9" "1" "2" "1" "145" "16.3" "8.60" "4.22" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;mitochondrion;other cell component" "transporter activity;other molecular function" "Pf02064" "9804" "ENSG00000173726" "TOMM20" "A8K195; hsa:9804; Q15388; Q498B3; Q6IBT4" "" "Ub-specific processing proteases; Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6343955122227256194" "False" "High" "IsMasterProtein" "Q01831" "DNA repair protein complementing XP-C cells OS=Homo sapiens OX=9606 GN=XPC PE=1 SV=4" "0.000" "False" "4.058" "1" "1" "1" "1" "940" "105.9" "8.90" "3.01" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03835, Pf10403, Pf10404, Pf10405" "7508" "ENSG00000154767" "XPC" "B4DIP3; E9PB96; E9PH69; hsa:7508; Q01831; Q53GT7; Q96AX0" "Male infertility; Nucleotide excision repair; DNA repair pathways, full network; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum" "SUMOylation of DNA damage response and repair proteins; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "8" "0" "0.977" "0.714" "1.088" "1.131" "0.939" "1.246" "0.880" "0.933" "1.248" "42.1" "41.1" "30.0" "45.8" "47.6" "39.5" "52.4" "37.0" "39.3" "52.5" "" "" "" "" "" "" "" "" "" "" "25.2" "21.4" "16.6" "21.5" "22.1" "20.2" "24.4" "16.6" "21.3" "52.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9042131036706186365" "False" "High" "IsMasterProtein" "Q13485" "Mothers against decapentaplegic homolog 4 OS=Homo sapiens OX=9606 GN=SMAD4 PE=1 SV=1" "0.000" "False" "4.058" "3" "2" "2" "2" "552" "60.4" "6.99" "2.72" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4089" "ENSG00000141646" "SMAD4" "A8K405; hsa:4089; Q13485" "Androgen receptor signaling pathway; Bone morphogenic protein signaling and regulation; Heart development; Cell cycle; Endoderm differentiation; Mesodermal commitment pathway; Ectoderm differentiation; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Hepatitis C and hepatocellular carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Vitamin D in inflammatory diseases; Envelope proteins and their potential roles in EDMD physiopathology; Hepatitis B infection; Head and neck squamous cell carcinoma; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Angiotensin II receptor type 1 pathway; Neuroinflammation and glutamatergic signaling; Progeria-associated lipodystrophy; Clock-controlled autophagy in bone metabolism; Rubinstein-Taybi syndrome 1; TGF-beta receptor signaling; DNA damage response (only ATM dependent)" "Ub-specific processing proteases; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Signaling by BMP; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Cardiogenesis; Germ layer formation at gastrulation; Formation of definitive endoderm; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Transcriptional regulation of pluripotent stem cells; RUNX3 regulates BCL2L11 (BIM) transcription; RUNX2 regulates bone development; Signaling by Activin; TGF-beta receptor signaling activates SMADs; RUNX3 regulates CDKN1A transcription; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer" "53" "0" "1.135" "1.209" "1.202" "1.212" "1.214" "1.180" "1.169" "1.348" "1.719" "137.4" "156.0" "166.2" "165.2" "166.5" "166.9" "162.2" "160.7" "185.3" "236.2" "" "" "" "" "" "" "" "" "" "" "82.2" "81.1" "92.0" "77.6" "77.2" "85.4" "75.4" "72.1" "100.5" "236.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4927987348987010712" "False" "High" "IsMasterProtein" "P35790" "Choline kinase alpha OS=Homo sapiens OX=9606 GN=CHKA PE=1 SV=3" "0.000" "False" "4.055" "4" "2" "3" "2" "457" "52.2" "6.55" "5.77" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01633" "1119" "ENSG00000110721" "CHKA" "hsa:1119; P35790; Q8NE29" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Acetylcholine synthesis" "Synthesis of PC; Synthesis of PE" "6" "0" "0.804" "0.817" "1.084" "1.117" "0.930" "1.016" "1.111" "0.852" "1.018" "79.4" "63.8" "64.9" "86.1" "88.7" "73.9" "80.7" "88.2" "67.6" "80.8" "" "" "" "" "" "" "" "" "" "" "47.5" "33.2" "35.9" "40.4" "41.1" "37.8" "37.5" "39.6" "36.7" "80.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8041398226355410347" "False" "High" "IsMasterProtein" "Q9NUL5" "Shiftless antiviral inhibitor of ribosomal frameshifting protein OS=Homo sapiens OX=9606 GN=SHFL PE=1 SV=2" "0.000" "False" "4.051" "6" "2" "2" "2" "291" "33.1" "7.25" "4.74" "2" "stress response;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf15135" "55337" "ENSG00000130813" "SHFL" "A8MQT9; hsa:55337; Q4G188; Q8IYH6; Q8N8V1; Q9NUL5" "" "" "0" "0" "1.115" "0.767" "0.958" "0.854" "1.137" "0.665" "1.086" "1.096" "0.851" "20.1" "22.4" "15.4" "19.3" "17.2" "22.9" "13.4" "21.9" "22.1" "17.1" "" "" "" "" "" "" "" "" "" "" "12.1" "11.7" "8.6" "9.1" "8.0" "11.7" "6.2" "9.8" "12.0" "17.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8567537084386512250" "False" "High" "IsMasterProtein" "P20933" "N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase OS=Homo sapiens OX=9606 GN=AGA PE=1 SV=2" "0.000" "False" "4.038" "6" "1" "1" "1" "346" "37.2" "6.28" "3.00" "1" "protein metabolism;other metabolic processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01112" "175" "ENSG00000038002" "AGA" "B2R7H2; D3DP47; hsa:175; P20933; Q4W5Q2; Q6FHN6; Q9UCK6; Q9UCK7; Q9UCK8" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4923515790283792107" "False" "High" "IsMasterProtein" "Q7Z309" "PABIR family member 2 OS=Homo sapiens OX=9606 GN=PABIR2 PE=1 SV=2" "0.000" "False" "4.026" "9" "2" "2" "2" "247" "26.9" "6.37" "0.00" "2" "" "" "enzyme regulator activity" "" "159090" "ENSG00000156504" "PABIR2" "A8K902; hsa:159090; Q6PIM2; Q6ZU47; Q6ZV64; Q6ZVE4; Q7Z309; Q8TB75" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-692133851352470930" "False" "High" "IsMasterProtein" "Q14376" "UDP-glucose 4-epimerase OS=Homo sapiens OX=9606 GN=GALE PE=1 SV=2" "0.000" "False" "4.006" "5" "1" "1" "1" "348" "38.3" "6.73" "2.42" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf16363" "2582" "ENSG00000117308" "GALE" "A0A024RAH5; B3KQ39; hsa:2582; Q14376; Q38G75; Q86W41; Q9BVE3; Q9UJB4" "Disorders of galactose metabolism ; UDP-derived sugars synthesis in fibroblasts" "Galactose catabolism; Defective GALE causes EDG" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8425175822669482526" "False" "High" "IsMasterProtein" "Q9NRY5" "Protein FAM114A2 OS=Homo sapiens OX=9606 GN=FAM114A2 PE=1 SV=4" "0.000" "False" "3.995" "2" "1" "1" "1" "505" "55.4" "4.88" "3.42" "1" "" "" "other molecular function" "Pf05334" "10827" "ENSG00000055147" "FAM114A2" "B2R8D8; hsa:10827; Q9H7E0; Q9NRY5" "" "Signaling by BRAF and RAF1 fusions" "1" "0" "0.909" "1.577" "1.320" "1.296" "1.301" "1.281" "0.764" "1.713" "3.907" "23.3" "21.1" "36.7" "30.7" "30.1" "30.3" "29.8" "17.8" "39.8" "90.9" "" "" "" "" "" "" "" "" "" "" "13.9" "11.0" "20.3" "14.4" "14.0" "15.5" "13.9" "8.0" "21.6" "90.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7431062919970507924" "False" "High" "IsMasterProtein" "P62891" "Large ribosomal subunit protein eL39 OS=Homo sapiens OX=9606 GN=RPL39 PE=1 SV=2" "0.000" "False" "3.988" "20" "1" "4" "1" "51" "6.4" "12.56" "10.55" "1" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;cytosol;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00832" "6170" "ENSG00000198918" "RPL39" "hsa:6170; P02404; P39025; P62891; Q9BYF2" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.025" "1.178" "1.090" "1.032" "1.132" "1.204" "0.857" "1.121" "2.475" "161.6" "165.7" "190.3" "176.1" "166.7" "182.9" "194.5" "138.4" "181.1" "400.0" "" "" "" "" "" "" "" "" "" "" "96.7" "86.1" "105.4" "82.7" "77.3" "93.6" "90.4" "62.1" "98.3" "400.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4269157593658569788" "False" "High" "IsMasterProtein" "Q9NXV2" "BTB/POZ domain-containing protein KCTD5 OS=Homo sapiens OX=9606 GN=KCTD5 PE=1 SV=1" "0.000" "False" "3.987" "6" "1" "1" "1" "234" "26.1" "6.24" "3.31" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02214" "54442" "ENSG00000167977" "KCTD5" "D3DU96; hsa:54442; Q9NXV2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-474422990152712875" "False" "High" "IsMasterProtein" "P61923" "Coatomer subunit zeta-1 OS=Homo sapiens OX=9606 GN=COPZ1 PE=1 SV=1" "0.000" "False" "3.984" "6" "1" "1" "1" "177" "20.2" "4.81" "3.86" "1" "transport" "other membranes;cytosol;ER/Golgi" "" "Pf01217" "22818" "ENSG00000111481" "COPZ1" "B4DDX8; B4DHZ0; F8VS17; F8VWL5; hsa:22818; P61923; Q549N6; Q9Y3C3" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "0.844" "1.090" "1.122" "1.175" "1.222" "1.093" "1.157" "0.973" "1.960" "88.8" "75.0" "96.8" "99.6" "104.4" "108.5" "97.1" "102.7" "86.4" "174.1" "" "" "" "" "" "" "" "" "" "" "53.1" "39.0" "53.6" "46.8" "48.4" "55.5" "45.1" "46.1" "46.9" "174.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5427058765005465503" "False" "High" "IsMasterProtein" "Q7Z6I8" "UPF0461 protein C5orf24 OS=Homo sapiens OX=9606 GN=C5orf24 PE=1 SV=1" "0.000" "False" "3.973" "8" "1" "1" "1" "188" "20.1" "9.85" "3.09" "1" "" "" "" "Pf17724" "134553" "ENSG00000181904" "C5orf24" "D3DQA7; hsa:134553; Q7Z6I8; Q86Y53; Q8N1T9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-973328225883047536" "False" "High" "IsMasterProtein" "Q8IV48" "3'-5' exoribonuclease 1 OS=Homo sapiens OX=9606 GN=ERI1 PE=1 SV=3" "0.000" "False" "3.971" "5" "2" "2" "2" "349" "40.0" "6.70" "4.66" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00929, Pf02037" "90459" "ENSG00000104626" "ERI1" "A8K4U7; hsa:90459; Q8IV48; Q9NSX3" "exRNA mechanism of action and biogenesis; 8p23.1 copy number variation syndrome; 4p16.3 copy number variation" "Major pathway of rRNA processing in the nucleolus and cytosol" "4" "0" "0.984" "0.986" "0.971" "1.001" "1.092" "1.045" "0.688" "1.098" "4.674" "116.3" "114.5" "114.6" "113.0" "116.4" "127.0" "121.5" "80.0" "127.7" "543.6" "" "" "" "" "" "" "" "" "" "" "69.6" "59.5" "63.5" "53.0" "53.9" "65.0" "56.5" "35.9" "69.3" "543.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5286637805257654056" "False" "High" "IsMasterProtein" "Q9BQG0" "Myb-binding protein 1A OS=Homo sapiens OX=9606 GN=MYBBP1A PE=1 SV=2" "0.000" "False" "3.969" "1" "1" "1" "1" "1328" "148.8" "9.28" "2.99" "1" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04931" "10514" "ENSG00000132382" "MYBBP1A" "hsa:10514; Q86VM3; Q9BQG0; Q9BW49; Q9P0V5; Q9UF99" "Energy metabolism; 10q11.21q11.23 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression" "3" "0" "1.525" "2.357" "0.010" "1.071" "1.924" "0.010" "0.565" "1.585" "18.747" "4.6" "7.0" "10.8" "0.0" "4.9" "8.8" "0.0" "2.6" "7.3" "86.0" "" "" "" "" "" "" "" "" "" "" "2.7" "3.6" "6.0" "0.0" "2.3" "4.5" "0.0" "1.2" "3.9" "86.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "Not Found" "High" "High" "Not Found" "High" "High" "High" "1" "" "2096625671163089170" "False" "High" "IsMasterProtein" "O95999" "B-cell lymphoma/leukemia 10 OS=Homo sapiens OX=9606 GN=BCL10 PE=1 SV=1" "0.000" "False" "3.969" "4" "1" "1" "1" "233" "26.2" "5.74" "2.84" "1" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00619" "8915" "ENSG00000142867" "BCL10" "hsa:8915; O95999; Q5VUF1" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8029242028913948624" "False" "High" "IsMasterProtein" "Q92614" "Unconventional myosin-XVIIIa OS=Homo sapiens OX=9606 GN=MYO18A PE=1 SV=3" "0.000" "False" "3.964" "0" "1" "1" "1" "2054" "233.0" "6.30" "2.58" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00063, Pf00595, Pf01576" "399687" "ENSG00000196535" "MYO18A" "hsa:399687; Q5H9U3; Q5QD01; Q5W9F9; Q5W9G1; Q8IXP8; Q92614" "" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by FLT3 fusion proteins" "3" "0" "0.885" "1.078" "1.237" "1.127" "1.083" "1.225" "1.162" "0.887" "3.725" "38.8" "34.3" "41.8" "48.0" "43.7" "42.1" "47.5" "45.1" "34.4" "144.6" "" "" "" "" "" "" "" "" "" "" "23.2" "17.8" "23.2" "22.5" "20.3" "21.5" "22.1" "20.2" "18.7" "144.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4711038865420362592" "False" "High" "IsMasterProtein" "Q9BRV8" "Suppressor of IKBKE 1 OS=Homo sapiens OX=9606 GN=SIKE1 PE=1 SV=1" "0.000" "False" "3.964" "7" "1" "1" "1" "207" "23.7" "5.21" "3.66" "1" "" "cytosol" "other molecular function" "Pf05769" "80143" "ENSG00000052723" "SIKE1" "hsa:80143; Q5TEZ7; Q5TEZ9; Q68DZ4; Q9BRV8; Q9H778" "Novel intracellular components of RIG-I-like receptor pathway" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; SARS-CoV-1 activates/modulates innate immune responses; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3713155333032135901" "False" "High" "IsMasterProtein" "Q9HA38" "Zinc finger matrin-type protein 3 OS=Homo sapiens OX=9606 GN=ZMAT3 PE=1 SV=1" "0.000" "False" "3.963" "6" "1" "1" "1" "289" "32.0" "8.90" "2.62" "1" "stress response;transport;other biological processes" "plasma membrane;other membranes;nucleus" "other molecular function" "Pf12171, Pf12874" "64393" "ENSG00000172667" "ZMAT3" "B3KVA6; D3DNR1; hsa:64393; Q96A21; Q9HA38" "miRNA regulation of p53 pathway in prostate cancer; p53 transcriptional gene network" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7003283534467846840" "False" "High" "IsMasterProtein" "P40937" "Replication factor C subunit 5 OS=Homo sapiens OX=9606 GN=RFC5 PE=1 SV=1" "0.000" "False" "3.961" "5" "2" "2" "2" "340" "38.5" "7.20" "4.41" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5985" "ENSG00000111445" "RFC5" "A8MZ62; B3KSX8; hsa:5985; P40937" "Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "28" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1392727006884078861" "False" "High" "IsMasterProtein" "P51692" "Signal transducer and activator of transcription 5B OS=Homo sapiens OX=9606 GN=STAT5B PE=1 SV=2" "0.000" "False" "3.954" "1" "1" "1" "1" "787" "89.8" "6.05" "3.37" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf21354" "6777" "ENSG00000173757" "STAT5B" "hsa:6777; P51692; Q8WWS8" "IL-5 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Chemokine signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; White fat cell differentiation; Non-small cell lung cancer; EGF/EGFR signaling pathway; Measles virus infection; Hepatitis B infection; Endochondral ossification; Endochondral ossification with skeletal dysplasias; IL-2 signaling pathway; 3q29 copy number variation syndrome; FOXP3 in COVID-19; Familial partial lipodystrophy; Acute myeloid leukemia; JAK-STAT signaling in the regulation of beta cells; EPO receptor signaling; ErbB signaling pathway" "Growth hormone receptor signaling; Interleukin-3, Interleukin-5 and GM-CSF signaling; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by Leptin; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; Prolactin receptor signaling; Interleukin-20 family signaling; Erythropoietin activates STAT5; Signaling by FLT3 fusion proteins; Interleukin-2 signaling; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling; STAT5 Activation" "51" "0" "0.794" "0.722" "0.903" "0.720" "0.998" "0.631" "0.561" "0.880" "4.654" "66.5" "52.8" "48.0" "60.1" "47.9" "66.4" "42.0" "37.3" "58.6" "309.7" "" "" "" "" "" "" "" "" "" "" "39.8" "27.5" "26.6" "28.2" "22.2" "34.0" "19.5" "16.8" "31.8" "309.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1220366376593556815" "False" "High" "IsMasterProtein" "Q9Y5U2" "U5 small nuclear ribonucleoprotein TSSC4 OS=Homo sapiens OX=9606 GN=TSSC4 PE=1 SV=3" "0.000" "False" "3.953" "6" "2" "2" "2" "329" "34.3" "5.19" "5.23" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf15264" "10078" "ENSG00000184281" "TSSC4" "C9JS66; hsa:10078; Q86VL2; Q9BRS6; Q9Y5U2" "" "" "0" "0" "1.005" "0.845" "0.986" "1.030" "1.002" "1.140" "0.939" "0.890" "0.894" "84.8" "85.3" "71.7" "83.6" "87.4" "85.0" "96.7" "79.7" "75.5" "75.8" "" "" "" "" "" "" "" "" "" "" "50.7" "44.3" "39.7" "39.3" "40.5" "43.5" "45.0" "35.8" "41.0" "75.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1388353290409054284" "False" "High" "IsMasterProtein" "Q9NNW7" "Thioredoxin reductase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TXNRD2 PE=1 SV=3" "0.000" "False" "3.943" "3" "1" "1" "1" "524" "56.5" "7.50" "3.17" "1" "stress response;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf02852, Pf07992" "10587" "ENSG00000184470" "TXNRD2" "hsa:10587; O95840; Q96IJ2; Q9H2Z5; Q9NNW7; Q9NZV3; Q9NZV4; Q9P2Y0; Q9P2Y1; Q9UQU8" "Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Selenium metabolism and selenoproteins; Oxidative stress response; 22q11.2 copy number variation syndrome" "Detoxification of Reactive Oxygen Species" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4147334840207979337" "False" "High" "IsMasterProtein" "Q8WUN7" "Ubiquitin domain-containing protein 2 OS=Homo sapiens OX=9606 GN=UBTD2 PE=1 SV=2" "0.000" "False" "3.943" "6" "1" "1" "1" "234" "26.2" "5.67" "2.28" "1" "" "other cell component" "" "Pf00240, Pf16455" "92181" "ENSG00000168246" "UBTD2" "hsa:92181; Q8TDQ3; Q8WUN7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3736107449275984803" "False" "High" "IsMasterProtein" "Q96M96" "FYVE, RhoGEF and PH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=FGD4 PE=1 SV=2" "0.000" "False" "3.943" "1" "1" "1" "1" "766" "86.6" "6.13" "2.77" "1" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00169, Pf00621, Pf01363" "121512" "ENSG00000139132" "FGD4" "hsa:121512; Q6ULS2; Q8TCP6; Q96M96" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Intracellular trafficking proteins involved in CMT neuropathy" "CDC42 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "6" "0" "1.107" "1.087" "1.035" "1.310" "1.330" "1.118" "1.435" "0.911" "1.378" "54.5" "60.3" "59.3" "56.4" "71.4" "72.5" "60.9" "78.2" "49.6" "75.1" "" "" "" "" "" "" "" "" "" "" "32.6" "31.4" "32.8" "26.5" "33.1" "37.1" "28.3" "35.1" "26.9" "75.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6653368877228174187" "False" "High" "IsMasterProtein" "Q9NRX2" "Large ribosomal subunit protein bL17m OS=Homo sapiens OX=9606 GN=MRPL17 PE=1 SV=1" "0.000" "False" "3.939" "15" "2" "2" "2" "175" "20.0" "10.11" "1.93" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01196" "63875" "ENSG00000158042" "MRPL17" "D3DQU3; hsa:63875; Q6IAH8; Q96Q53; Q9C066; Q9NRX2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8023597143087882212" "False" "High" "IsMasterProtein" "P61925" "cAMP-dependent protein kinase inhibitor alpha OS=Homo sapiens OX=9606 GN=PKIA PE=1 SV=2" "0.000" "False" "3.933" "20" "1" "1" "1" "76" "8.0" "4.54" "3.20" "1" "other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02827" "5569" "ENSG00000171033" "PKIA" "hsa:5569; P04541; P61925; Q6IAV2" "Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "" "2" "0" "0.712" "0.435" "0.690" "1.047" "0.787" "0.714" "1.334" "0.589" "0.346" "28.6" "20.4" "12.5" "19.8" "30.0" "22.5" "20.4" "38.2" "16.9" "9.9" "" "" "" "" "" "" "" "" "" "" "17.1" "10.6" "6.9" "9.3" "13.9" "11.5" "9.5" "17.2" "9.1" "9.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4612502200950371664" "False" "High" "IsMasterProtein" "Q86V21" "Acetoacetyl-CoA synthetase OS=Homo sapiens OX=9606 GN=AACS PE=1 SV=1" "0.000" "False" "3.919" "3" "2" "2" "2" "672" "75.1" "6.24" "1.92" "2" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00501, Pf16177" "65985" "ENSG00000081760" "AACS" "hsa:65985; Q49AB9; Q49AC3; Q658Q8; Q86V21; Q8IWD2; Q8NEW5; Q9BSJ9; Q9H829; Q9HA19" "" "Synthesis of Ketone Bodies" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "141064915599705120" "False" "High" "IsMasterProtein" "Q9P000" "COMM domain-containing protein 9 OS=Homo sapiens OX=9606 GN=COMMD9 PE=1 SV=2" "0.000" "False" "3.912" "5" "1" "1" "1" "198" "21.8" "5.88" "3.14" "1" "transport;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf07258, Pf20923" "29099" "ENSG00000110442" "COMMD9" "E9PAN2; hsa:29099; Q96FI2; Q9H0R0; Q9P000" "" "Neutrophil degranulation; Neddylation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6043879365308815932" "False" "High" "IsMasterProtein" "O75818" "Ribonuclease P protein subunit p40 OS=Homo sapiens OX=9606 GN=RPP40 PE=1 SV=3" "0.000" "False" "3.904" "6" "2" "4" "2" "363" "41.8" "6.67" "9.44" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08584" "10799" "ENSG00000124787" "RPP40" "hsa:10799; O75818; Q5VX97; Q8WVK8" "" "tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol" "2" "0" "0.994" "0.995" "0.987" "0.880" "1.082" "0.772" "1.027" "0.956" "0.547" "207.1" "205.8" "206.0" "204.3" "182.2" "224.1" "159.8" "212.7" "197.9" "113.4" "" "" "" "" "" "" "" "" "" "" "123.9" "106.9" "114.1" "95.9" "84.5" "114.7" "74.3" "95.5" "107.4" "113.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8526861795692287608" "False" "High" "IsMasterProtein" "Q6PK04" "Coiled-coil domain-containing protein 137 OS=Homo sapiens OX=9606 GN=CCDC137 PE=1 SV=1" "0.000" "False" "3.899" "3" "1" "1" "1" "289" "33.2" "10.93" "3.20" "1" "" "nucleus;other cell component" "" "" "339230" "ENSG00000185298" "CCDC137" "hsa:339230; Q6PK04" "" "" "0" "0" "1.046" "1.090" "1.298" "0.909" "1.038" "0.913" "1.430" "1.197" "0.618" "46.6" "48.8" "50.8" "60.6" "42.4" "48.4" "42.6" "66.7" "55.8" "28.8" "" "" "" "" "" "" "" "" "" "" "27.9" "25.3" "28.1" "28.4" "19.7" "24.8" "19.8" "29.9" "30.3" "28.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5765890645847651977" "False" "High" "IsMasterProtein" "Q14790" "Caspase-8 OS=Homo sapiens OX=9606 GN=CASP8 PE=1 SV=1" "0.000" "False" "3.893" "2" "1" "1" "1" "479" "55.4" "5.10" "2.47" "1" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00656, Pf01335" "841" "ENSG00000064012" "CASP8" "hsa:841; O14676; Q14790; Q14791; Q14792; Q14793; Q14794; Q14795; Q14796; Q15780; Q15806; Q53TT5; Q8TDI1; Q8TDI2; Q8TDI3; Q8TDI4; Q8TDI5; Q96T22; Q9C0K4; Q9UQ81" "Nucleotide-binding oligomerization domain (NOD) pathway; miRNA regulation of DNA damage response; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft rejection; Parkin-ubiquitin proteasomal system pathway; Nanomaterial induced apoptosis; Nanoparticle triggered regulated necrosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; miRNA regulation of p53 pathway in prostate cancer; Non-small cell lung cancer; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; 16p11.2 proximal deletion syndrome; Complement system in neuronal development and plasticity; CCL18 signaling pathway; Alzheimer's disease; DNA damage response; Toll-like receptor signaling pathway" "Regulation of TNFR1 signaling; TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TRAIL signaling; NOD1/2 Signaling Pathway; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Regulation of NF-kappa B signaling; TLR3-mediated TICAM1-dependent programmed cell death; Caspase-mediated cleavage of cytoskeletal proteins; TNFR1-induced proapoptotic signaling; CLEC7A/inflammasome pathway; Microbial modulation of RIPK1-mediated regulated necrosis; Activation, myristolyation of BID and translocation to mitochondria; FasL/ CD95L signaling; Defective RIPK1-mediated regulated necrosis" "54" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5531116507177860716" "False" "High" "IsMasterProtein" "Q06609" "DNA repair protein RAD51 homolog 1 OS=Homo sapiens OX=9606 GN=RAD51 PE=1 SV=1" "0.000" "False" "3.886" "4" "2" "2" "2" "339" "36.9" "5.60" "6.00" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423, Pf14520" "5888" "ENSG00000051180" "RAD51" "B0FXP0; B2R8T6; hsa:5888; Q06609; Q6FHX9; Q6ZNA8; Q9BV60" "miRNA regulation of DNA damage response; Homologous recombination; ATM signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Ovarian infertility; Breast cancer pathway; Pancreatic adenocarcinoma pathway; DNA repair pathways, full network; Primary ovarian insufficiency; DNA damage response" "Resolution of D-loop Structures through Holliday Junction Intermediates; Transcriptional Regulation by E2F6; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "23" "0" "0.947" "0.827" "1.013" "1.031" "1.081" "1.254" "1.337" "1.162" "0.999" "375.0" "355.1" "310.0" "380.0" "386.6" "405.5" "470.4" "501.4" "435.9" "374.6" "" "" "" "" "" "" "" "" "" "" "224.4" "184.5" "171.7" "178.4" "179.2" "207.6" "218.7" "225.1" "236.5" "374.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6680775627371570044" "False" "High" "IsMasterProtein" "Q9Y6V0" "Protein piccolo OS=Homo sapiens OX=9606 GN=PCLO PE=1 SV=5" "0.000" "False" "3.885" "0" "2" "3" "2" "5142" "560.4" "6.47" "5.72" "2" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00168, Pf00595, Pf05715" "27445" "ENSG00000186472" "PCLO" "A4D1A7; A6NNX9; O43373; O60305; Q08E72; Q9BVC8; Q9UIV2; Q9Y6U9; Q9Y6V0" "Cell lineage map for neuronal differentiation" "Sensory processing of sound by inner hair cells of the cochlea" "2" "0" "1.044" "1.096" "1.353" "1.122" "1.141" "1.105" "1.236" "0.981" "0.690" "140.8" "146.9" "154.4" "190.6" "158.0" "160.7" "155.6" "174.0" "138.2" "97.2" "" "" "" "" "" "" "" "" "" "" "84.3" "76.4" "85.5" "89.5" "73.3" "82.3" "72.4" "78.1" "75.0" "97.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1377000983824553191" "False" "High" "IsMasterProtein" "Q8N5N7" "Large ribosomal subunit protein mL50 OS=Homo sapiens OX=9606 GN=MRPL50 PE=1 SV=2" "0.000" "False" "3.884" "7" "1" "1" "1" "158" "18.3" "7.88" "3.53" "1" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "" "Pf10501" "54534" "ENSG00000136897" "MRPL50" "B7Z358; hsa:54534; Q5T7E0; Q8N5N7; Q9NX15" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.118" "0.875" "0.880" "0.877" "1.046" "1.096" "0.959" "0.860" "0.937" "81.1" "90.7" "70.9" "71.3" "71.1" "84.8" "88.8" "77.8" "69.7" "76.0" "" "" "" "" "" "" "" "" "" "" "48.5" "47.1" "39.3" "33.5" "33.0" "43.4" "41.3" "34.9" "37.8" "76.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9014101916445181907" "False" "High" "IsMasterProtein" "Q6BDS2" "Bridge-like lipid transfer protein family member 3A OS=Homo sapiens OX=9606 GN=BLTP3A PE=1 SV=1" "0.000" "False" "3.882" "1" "1" "1" "1" "1440" "159.4" "6.14" "2.51" "1" "" "other cytoplasmic organelle" "other molecular function" "Pf12624" "54887" "ENSG00000065060" "BLTP3A" "hsa:54887; Q6BDS2; Q9NXE0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5430220103658382973" "False" "High" "IsMasterProtein" "Q969Q0" "Ribosomal protein eL42-like OS=Homo sapiens OX=9606 GN=RPL36AL PE=1 SV=3" "0.000" "False" "3.880" "8" "1" "1" "1" "106" "12.5" "10.65" "3.25" "1" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;translational apparatus;nucleus" "other molecular function" "Pf00935" "6166" "ENSG00000165502" "RPL36AL" "hsa:6166; Q3B7A5; Q969Q0" "" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "13" "0" "1.206" "1.309" "1.285" "1.217" "1.534" "1.205" "1.247" "1.405" "1.517" "127.7" "154.0" "167.1" "164.1" "155.3" "195.8" "153.8" "159.1" "179.3" "193.6" "" "" "" "" "" "" "" "" "" "" "76.4" "80.0" "92.5" "77.0" "72.0" "100.2" "71.5" "71.4" "97.3" "193.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6190490643753871552" "False" "High" "IsMasterProtein" "Q8WTX7" "Cytosolic arginine sensor for mTORC1 subunit 1 OS=Homo sapiens OX=9606 GN=CASTOR1 PE=1 SV=1" "0.000" "False" "3.866" "3" "1" "1" "1" "329" "36.3" "5.19" "3.54" "1" "stress response;other biological processes" "cytosol" "other molecular function" "Pf13840, Pf18700, Pf21389" "652968" "ENSG00000239282" "CASTOR1" "hsa:652968; O76052; Q8WTX7; Q96ND9; Q9UIE8" "" "Amino acids regulate mTORC1" "1" "0" "1.166" "1.236" "1.097" "1.082" "0.920" "1.205" "1.177" "1.012" "1.073" "56.1" "65.4" "69.4" "61.6" "60.7" "51.6" "67.6" "66.1" "56.8" "60.2" "" "" "" "" "" "" "" "" "" "" "33.6" "34.0" "38.4" "28.9" "28.1" "26.4" "31.4" "29.7" "30.8" "60.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-903234592047053827" "False" "High" "IsMasterProtein" "Cont_Q7M135" "Lysyl endopeptidase OS=Lysobacter enzymogenes OX=69 PE=1 SV=1" "0.001" "True" "3.865" "7" "1" "1" "1" "269" "27.9" "6.71" "2.58" "1" "protein metabolism" "non-structural extracellular" "other molecular function" "Pf13365" "" "" "" "" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8867340794532680383" "False" "High" "IsMasterProtein" "O94967" "WD repeat-containing protein 47 OS=Homo sapiens OX=9606 GN=WDR47 PE=1 SV=1" "0.001" "False" "3.859" "1" "1" "1" "1" "919" "101.9" "5.94" "2.75" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;other cell component" "" "Pf00400, Pf17814" "22911" "ENSG00000085433" "WDR47" "A8MX09; hsa:22911; O94967; Q5TYV7; Q5TYV8; Q5TYV9; Q8IXT7; Q8IYU9" "" "" "0" "0" "0.689" "0.588" "0.758" "0.939" "0.767" "0.546" "0.726" "0.865" "0.486" "38.6" "26.6" "22.7" "29.2" "36.2" "29.6" "21.1" "28.0" "33.4" "18.8" "" "" "" "" "" "" "" "" "" "" "23.1" "13.8" "12.6" "13.7" "16.8" "15.1" "9.8" "12.6" "18.1" "18.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6622895814543661851" "False" "High" "IsMasterProtein" "O15504" "Nucleoporin NUP42 OS=Homo sapiens OX=9606 GN=NUP42 PE=1 SV=1" "0.001" "False" "3.857" "4" "2" "2" "2" "423" "44.8" "9.19" "1.92" "2" "transport" "other membranes;cytosol;nucleus" "other molecular function" "Pf18044" "11097" "ENSG00000136243" "NUP42" "A4D143; B4DP42; hsa:11097; O15504; Q49AE7; Q9BS49" "" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "28" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7547854547274614235" "False" "High" "IsMasterProtein" "Q66K74" "Microtubule-associated protein 1S OS=Homo sapiens OX=9606 GN=MAP1S PE=1 SV=2" "0.001" "False" "3.850" "1" "1" "3" "1" "1059" "112.1" "7.30" "6.73" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "" "55201" "ENSG00000130479" "MAP1S" "B4DH53; hsa:55201; Q27QB1; Q66K74; Q6NXF1; Q8N3L8; Q8N3W5; Q8NI88; Q96H94; Q96IT4; Q96SP8; Q9BRC6; Q9H928; Q9NVK7" "" "" "0" "0" "0.925" "1.873" "1.571" "0.965" "1.696" "1.881" "0.792" "1.377" "5.383" "11.4" "10.5" "21.3" "17.8" "11.0" "19.3" "21.4" "9.0" "15.6" "61.1" "" "" "" "" "" "" "" "" "" "" "6.8" "5.5" "11.8" "8.4" "5.1" "9.9" "9.9" "4.0" "8.5" "61.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6142056770574276442" "False" "High" "IsMasterProtein" "Q96T58" "Msx2-interacting protein OS=Homo sapiens OX=9606 GN=SPEN PE=1 SV=1" "0.001" "False" "3.840" "1" "2" "2" "2" "3664" "402.0" "7.64" "1.81" "2" "signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf07744, Pf20808, Pf20809, Pf20810" "23013" "ENSG00000065526" "SPEN" "hsa:23013; Q96T58; Q9H9A8; Q9NWH5; Q9UQ01; Q9Y556" "Notch signaling pathway" "RHOBTB1 GTPase cycle" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3408617602849881412" "False" "High" "IsMasterProtein" "Q9UKU7" "Isobutyryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAD8 PE=1 SV=1" "0.001" "False" "3.840" "2" "1" "2" "1" "415" "45.0" "7.85" "3.55" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "27034" "ENSG00000151498" "ACAD8" "B7Z5W4; hsa:27034; Q6ZWP6; Q9BUS8; Q9UKU7" "" "Mitochondrial protein degradation; Branched-chain amino acid catabolism" "2" "0" "1.151" "1.021" "1.044" "1.196" "1.268" "1.009" "1.316" "0.988" "0.659" "209.3" "240.9" "213.7" "218.4" "250.4" "265.4" "211.2" "275.4" "206.8" "137.9" "" "" "" "" "" "" "" "" "" "" "125.3" "125.2" "118.4" "102.5" "116.1" "135.9" "98.2" "123.6" "112.2" "137.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2661255315618113722" "False" "High" "IsMasterProtein" "O43493" "Trans-Golgi network integral membrane protein 2 OS=Homo sapiens OX=9606 GN=TGOLN2 PE=1 SV=4" "0.001" "False" "3.838" "3" "1" "1" "1" "437" "45.9" "5.63" "2.72" "1" "" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle" "" "Pf17818" "10618" "ENSG00000152291; ENSG00000292253" "TGOLN2" "B2R686; B8ZZ88; D6W5K3; F8W8W7; F8WBK2; hsa:10618; J3KQ45; O15282; O43492; O43493; O43499; O43500; O43501; Q53G68; Q53GV2; Q6MZV1; Q6ZTM7; Q8N6T8; Q92760; Q96QL2" "" "Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Retrograde transport at the Trans-Golgi-Network" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5846443296709188562" "False" "High" "IsMasterProtein" "Q9Y248" "DNA replication complex GINS protein PSF2 OS=Homo sapiens OX=9606 GN=GINS2 PE=1 SV=1" "0.001" "False" "3.837" "14" "2" "2" "2" "185" "21.4" "5.44" "0.00" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus" "" "Pf05916" "51659" "ENSG00000131153" "GINS2" "D3DUM5; hsa:51659; Q6IAG9; Q9Y248" "" "Unwinding of DNA" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7687733002656654502" "False" "High" "IsMasterProtein" "P18031" "Tyrosine-protein phosphatase non-receptor type 1 OS=Homo sapiens OX=9606 GN=PTPN1 PE=1 SV=1" "0.001" "False" "3.834" "2" "1" "1" "1" "435" "49.9" "6.27" "2.68" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00102" "5770" "ENSG00000196396" "PTPN1" "hsa:5770; P18031; Q5TGD8; Q9BQV9; Q9NQQ4" "Leptin signaling pathway; Prolactin signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling" "Insulin receptor recycling; Growth hormone receptor signaling; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Negative regulation of MET activity; Integrin signaling; MECP2 regulates neuronal receptors and channels; PTK6 Down-Regulation" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1948602544583202968" "False" "High" "IsMasterProtein" "Q13042" "Cell division cycle protein 16 homolog OS=Homo sapiens OX=9606 GN=CDC16 PE=1 SV=2" "0.001" "False" "3.820" "2" "1" "1" "1" "620" "71.6" "5.85" "2.73" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf12895, Pf13424" "8881" "ENSG00000130177" "CDC16" "A2A365; hsa:8881; Q13042; Q5T8C8; Q7Z651; Q96AE6; Q9Y564" "Cell cycle" "Separation of Sister Chromatids; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "0.998" "0.617" "1.029" "1.238" "1.209" "1.074" "0.655" "1.071" "2.170" "48.8" "48.7" "30.1" "50.2" "60.4" "59.0" "52.4" "31.9" "52.2" "105.8" "" "" "" "" "" "" "" "" "" "" "29.2" "25.3" "16.7" "23.6" "28.0" "30.2" "24.4" "14.3" "28.3" "105.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7020268087964795198" "False" "High" "IsMasterProtein" "Q9Y3B7" "Large ribosomal subunit protein uL11m OS=Homo sapiens OX=9606 GN=MRPL11 PE=1 SV=1" "0.001" "False" "3.820" "6" "1" "1" "1" "192" "20.7" "9.91" "3.19" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00298, Pf03946" "65003" "ENSG00000174547" "MRPL11" "A6NLT0; A8K219; hsa:65003; Q32P46; Q96Q73; Q9Y3B7" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2457834817562912062" "False" "High" "IsMasterProtein" "Q9GZY8" "Mitochondrial fission factor OS=Homo sapiens OX=9606 GN=MFF PE=1 SV=1" "0.001" "False" "3.812" "4" "1" "1" "1" "342" "38.4" "8.95" "3.65" "1" "cell organization and biogenesis;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05644" "56947" "ENSG00000168958" "MFF" "hsa:56947; Q567U1; Q658R6; Q9BVZ1; Q9GZY8; Q9H690; Q9NRG8" "" "" "0" "0" "1.281" "1.215" "1.587" "1.742" "1.355" "1.588" "1.200" "1.395" "1.012" "32.7" "41.9" "39.7" "51.8" "56.9" "44.3" "51.9" "39.2" "45.6" "33.1" "" "" "" "" "" "" "" "" "" "" "19.6" "21.8" "22.0" "24.3" "26.4" "22.7" "24.1" "17.6" "24.7" "33.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2758038755542979545" "False" "High" "IsMasterProtein" "P61769" "Beta-2-microglobulin OS=Homo sapiens OX=9606 GN=B2M PE=1 SV=1" "0.001" "False" "3.803" "8" "1" "2" "1" "119" "13.7" "6.52" "6.32" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07654" "567" "ENSG00000166710; ENSG00000273686" "B2M" "hsa:567; P01884; P61769; Q540F8; Q6IAT8; Q9UCK0; Q9UD48; Q9UDF4" "IL-18 signaling pathway" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ER-Phagosome pathway; Neutrophil degranulation; Amyloid fiber formation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; DAP12 signaling; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Modulation by Mtb of host immune system; Nef mediated downregulation of MHC class I complex cell surface expression; Endosomal/Vacuolar pathway" "13" "0" "1.116" "1.313" "1.205" "1.106" "1.204" "1.110" "0.976" "1.106" "1.264" "63.6" "70.9" "83.5" "76.6" "70.3" "76.5" "70.6" "62.0" "70.3" "80.4" "" "" "" "" "" "" "" "" "" "" "38.0" "36.9" "46.2" "36.0" "32.6" "39.2" "32.8" "27.8" "38.1" "80.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1286800557191181783" "False" "High" "IsMasterProtein" "Q14686" "Nuclear receptor coactivator 6 OS=Homo sapiens OX=9606 GN=NCOA6 PE=1 SV=3" "0.001" "False" "3.789" "0" "1" "1" "1" "2063" "219.0" "9.36" "2.56" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13820" "23054" "ENSG00000198646" "NCOA6" "A6NLF1; B2RMN5; E1P5P7; hsa:23054; Q14686; Q9NTZ9; Q9UH74; Q9UK86" "Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Kleefstra syndrome" "Cytoprotection by HMOX1; Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Formation of WDR5-containing histone-modifying complexes; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Activation of gene expression by SREBF (SREBP); RORA activates gene expression" "15" "0" "1.586" "1.302" "1.410" "1.636" "1.373" "1.276" "1.366" "1.349" "1.071" "36.0" "57.2" "46.9" "50.8" "59.0" "49.5" "46.0" "49.2" "48.6" "38.6" "" "" "" "" "" "" "" "" "" "" "21.6" "29.7" "26.0" "23.9" "27.3" "25.3" "21.4" "22.1" "26.4" "38.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5641519450922138293" "False" "High" "IsMasterProtein" "P15954" "Cytochrome c oxidase subunit 7C, mitochondrial OS=Homo sapiens OX=9606 GN=COX7C PE=1 SV=1" "0.001" "False" "3.786" "14" "1" "1" "1" "63" "7.2" "10.27" "4.14" "1" "other metabolic processes" "other membranes;mitochondrion" "" "Pf02935" "1350" "ENSG00000127184" "COX7C" "hsa:1350; P15954; Q6NR81" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3672343249527762985" "False" "High" "IsMasterProtein" "Q9H8M7" "Ubiquitin carboxyl-terminal hydrolase MINDY-3 OS=Homo sapiens OX=9606 GN=MINDY3 PE=1 SV=1" "0.001" "False" "3.785" "4" "2" "2" "2" "445" "49.7" "4.77" "2.41" "2" "protein metabolism;other biological processes" "other membranes;nucleus" "other molecular function" "Pf13898" "80013" "ENSG00000148481" "MINDY3" "Q5SZ68; Q5SZ69; Q5SZ70; Q6IA40; Q6P7P0; Q7Z2S1; Q8WUF1; Q9H3I4; Q9H8M7" "" "" "0" "0" "0.868" "1.120" "1.047" "0.938" "0.755" "1.025" "1.183" "0.893" "1.478" "44.7" "38.8" "50.1" "46.8" "41.9" "33.7" "45.8" "52.9" "39.9" "66.1" "" "" "" "" "" "" "" "" "" "" "26.7" "20.2" "27.7" "22.0" "19.4" "17.3" "21.3" "23.7" "21.6" "66.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2630091394541072843" "False" "High" "IsMasterProtein" "Q9P2Y5" "UV radiation resistance-associated gene protein OS=Homo sapiens OX=9606 GN=UVRAG PE=1 SV=1" "0.001" "False" "3.784" "2" "2" "2" "2" "699" "78.1" "8.29" "3.95" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf10186" "7405" "ENSG00000198382" "UVRAG" "B3KTC1; hsa:7405; O00392; Q9P2Y5" "Nanoparticle triggered autophagic cell death; Autophagy" "Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; SARS-CoV-2 modulates autophagy" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6221912277285666984" "False" "High" "IsMasterProtein" "Q5TC12" "ATP synthase mitochondrial F1 complex assembly factor 1 OS=Homo sapiens OX=9606 GN=ATPAF1 PE=1 SV=1" "0.001" "False" "3.783" "3" "1" "1" "1" "328" "36.4" "7.96" "3.40" "1" "cell organization and biogenesis" "mitochondrion" "" "Pf06644" "64756" "ENSG00000123472" "ATPAF1" "B1AQW7; B7Z7D6; B7Z7I6; hsa:64756; Q5TC12; Q9H6E3" "7q11.23 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1688448728000248200" "False" "High" "IsMasterProtein" "Q9BZH6" "WD repeat-containing protein 11 OS=Homo sapiens OX=9606 GN=WDR11 PE=1 SV=1" "0.001" "False" "3.782" "1" "1" "8" "1" "1224" "136.6" "6.92" "15.58" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "" "" "55717" "ENSG00000120008" "WDR11" "hsa:55717; Q5VWA1; Q9BZH6; Q9P2J6" "" "RHOH GTPase cycle" "1" "0" "1.217" "1.174" "1.075" "1.061" "1.404" "0.873" "1.310" "1.009" "0.719" "207.0" "251.9" "243.0" "222.5" "219.7" "290.7" "180.7" "271.2" "209.0" "148.9" "" "" "" "" "" "" "" "" "" "" "123.9" "130.9" "134.6" "104.5" "101.8" "148.8" "84.0" "121.7" "113.4" "148.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1714630333721311506" "False" "High" "IsMasterProtein" "Q6NVY1" "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HIBCH PE=1 SV=2" "0.001" "False" "3.775" "3" "1" "1" "1" "386" "43.5" "8.19" "2.93" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf16113" "26275" "ENSG00000198130" "HIBCH" "D3DPI4; hsa:26275; Q53GA8; Q53GF2; Q53RF7; Q53TC6; Q6NVY1; Q92931; Q9BS94" "Amino acid metabolism" "Branched-chain amino acid catabolism" "2" "0" "0.949" "0.963" "1.142" "1.101" "0.964" "1.035" "0.982" "1.013" "3.025" "66.2" "62.8" "63.7" "75.6" "72.9" "63.8" "68.5" "65.0" "67.0" "200.1" "" "" "" "" "" "" "" "" "" "" "39.6" "32.6" "35.3" "35.5" "33.8" "32.7" "31.8" "29.2" "36.4" "200.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "588939397575272440" "False" "High" "IsMasterProtein" "Q7L2J0" "7SK snRNA methylphosphate capping enzyme OS=Homo sapiens OX=9606 GN=MEPCE PE=1 SV=1" "0.001" "False" "3.775" "3" "1" "1" "1" "689" "74.3" "9.57" "2.70" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06859" "56257" "ENSG00000146834" "MEPCE" "B3KP86; D6W5V7; hsa:56257; Q7L2J0; Q9NPD4" "IL-18 signaling pathway; 1p36 copy number variation syndrome" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "1529174177095472519" "False" "High" "IsMasterProtein" "O14777" "Kinetochore protein NDC80 homolog OS=Homo sapiens OX=9606 GN=NDC80 PE=1 SV=1" "0.001" "False" "3.766" "3" "2" "3" "2" "642" "73.9" "5.60" "3.71" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03801, Pf18077" "10403" "ENSG00000080986" "NDC80" "hsa:10403; O14777; Q6PJX2" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8714366505281620526" "False" "High" "IsMasterProtein" "Q7L5Y9" "E3 ubiquitin-protein transferase MAEA OS=Homo sapiens OX=9606 GN=MAEA PE=1 SV=1" "0.001" "False" "3.756" "3" "1" "1" "1" "396" "45.3" "8.69" "2.09" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10607" "10296" "ENSG00000090316" "MAEA" "hsa:10296; O95285; Q5JB54; Q6ZRD6; Q7L5Y9; Q9BQ11; Q9H9V6; Q9H9Z4; Q9NW84" "Ciliary landscape" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6802815428408388451" "False" "High" "IsMasterProtein" "Q9UK99" "F-box only protein 3 OS=Homo sapiens OX=9606 GN=FBXO3 PE=1 SV=3" "0.001" "False" "3.751" "5" "2" "2" "2" "471" "54.5" "5.00" "1.74" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00646, Pf04379, Pf09346" "26273" "ENSG00000110429" "FBXO3" "B3KY16; D3DR05; hsa:26273; Q86X90; Q9H0V2; Q9NUX2; Q9UK99" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8049844811418031107" "False" "High" "IsMasterProtein" "O95707" "Ribonuclease P protein subunit p29 OS=Homo sapiens OX=9606 GN=POP4 PE=1 SV=2" "0.001" "False" "3.744" "9" "2" "2" "2" "220" "25.4" "10.07" "2.35" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01868" "10775" "ENSG00000105171" "POP4" "hsa:10775; O95707; Q5XKL7; Q6FHW9; Q9UQQ3" "" "tRNA processing in the nucleus" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "203506742472389879" "False" "High" "IsMasterProtein" "Q5RL73" "RNA-binding protein 48 OS=Homo sapiens OX=9606 GN=RBM48 PE=1 SV=1" "0.001" "False" "3.737" "3" "1" "1" "1" "367" "41.8" "8.72" "2.89" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "" "84060" "ENSG00000127993" "RBM48" "B7Z2K5; B7ZL51; hsa:84060; Q5H9T2; Q5RL73; Q8IYW7; Q96NS0; Q9H0V7" "" "" "0" "0" "1.069" "1.231" "1.002" "0.850" "1.050" "1.226" "1.093" "0.880" "0.832" "56.5" "60.4" "69.5" "56.6" "48.0" "59.3" "69.2" "61.7" "49.7" "47.0" "" "" "" "" "" "" "" "" "" "" "33.8" "31.4" "38.5" "26.6" "22.2" "30.3" "32.2" "27.7" "27.0" "47.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1908349325239483376" "False" "High" "IsMasterProtein" "H7BZ55" "Ciliary rootlet coiled-coil protein 2 OS=Homo sapiens OX=9606 GN=CROCC2 PE=1 SV=4" "0.001" "False" "3.735" "1" "2" "3" "1" "1653" "185.5" "5.50" "7.09" "2" "" "cytoskeleton" "" "Pf15035" "" "ENSG00000226321" "CROCC2" "H7BZ55" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2217826250867961619" "False" "High" "IsMasterProtein" "Q6P4F2" "Ferredoxin-2, mitochondrial OS=Homo sapiens OX=9606 GN=FDX2 PE=1 SV=3" "0.001" "False" "3.730" "6" "1" "1" "1" "183" "19.5" "5.38" "4.12" "1" "cell organization and biogenesis;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00111" "112812" "ENSG00000267673" "FDX2" "B7Z6L7; Q6P4F2; Q8N8B8" "" "Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin" "5" "0" "0.964" "1.023" "0.954" "1.129" "0.931" "1.105" "0.988" "0.884" "0.698" "108.1" "104.1" "110.6" "103.1" "122.1" "100.6" "119.4" "106.8" "95.5" "75.4" "" "" "" "" "" "" "" "" "" "" "64.7" "54.1" "61.2" "48.4" "56.6" "51.5" "55.5" "47.9" "51.8" "75.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4744508132045603899" "False" "High" "IsMasterProtein" "Q9BZG8" "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 OS=Homo sapiens OX=9606 GN=DPH1 PE=1 SV=3" "0.001" "False" "3.729" "4" "2" "2" "2" "438" "48.1" "7.84" "4.36" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01866" "1801" "ENSG00000108963" "DPH1" "A0A6Q8JGF9; D3DTI3; hsa:1801; Q16439; Q4VBA2; Q9BTW7; Q9BZG8; Q9UCY0" "" "Synthesis of diphthamide-EEF2" "1" "0" "1.078" "1.012" "1.021" "1.162" "1.094" "1.034" "1.080" "0.789" "0.815" "82.4" "88.8" "83.3" "84.1" "95.7" "90.1" "85.2" "88.9" "65.0" "67.1" "" "" "" "" "" "" "" "" "" "" "49.3" "46.1" "46.1" "39.5" "44.4" "46.1" "39.6" "39.9" "35.2" "67.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4771647564776910413" "False" "High" "IsMasterProtein" "Q96JC9" "ELL-associated factor 1 OS=Homo sapiens OX=9606 GN=EAF1 PE=1 SV=1" "0.001" "False" "3.725" "5" "1" "1" "1" "268" "29.0" "5.40" "2.06" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09816" "85403" "ENSG00000144597" "EAF1" "B4E3F5; hsa:85403; Q8IW10; Q96JC9" "" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2811678325838740313" "False" "High" "IsMasterProtein" "Q9NXW9" "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 OS=Homo sapiens OX=9606 GN=ALKBH4 PE=1 SV=1" "0.001" "False" "3.721" "7" "2" "3" "2" "302" "33.8" "6.67" "0.00" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "54784" "ENSG00000160993" "ALKBH4" "hsa:54784; Q53H92; Q9H6A4; Q9NXW9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4972619903535100006" "False" "High" "IsMasterProtein" "P49916" "DNA ligase 3 OS=Homo sapiens OX=9606 GN=LIG3 PE=1 SV=2" "0.001" "False" "3.710" "2" "1" "1" "1" "1009" "112.8" "9.01" "2.27" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00645, Pf01068, Pf04675, Pf04679, Pf16759" "3980" "ENSG00000005156" "LIG3" "E5KLB5; E5KLB6; hsa:3980; P49916; Q16714; Q6NVK3" "Base excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 17q12 copy number variation syndrome" "Gap-filling DNA repair synthesis and ligation in TC-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; HDR through MMEJ (alt-NHEJ); Resolution of AP sites via the single-nucleotide replacement pathway; Gap-filling DNA repair synthesis and ligation in GG-NER" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "Not Found" "High" "1" "" "1311899877800093537" "False" "High" "IsMasterProtein" "Q9H0K6" "Pseudouridylate synthase PUS7L OS=Homo sapiens OX=9606 GN=PUS7L PE=1 SV=1" "0.001" "False" "3.707" "2" "2" "2" "2" "701" "80.6" "7.56" "2.37" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01142" "83448" "ENSG00000129317" "PUS7L" "B3KUJ1; hsa:83448; Q05CU0; Q6AHZ3; Q6NUP2; Q9H0K6" "" "" "0" "0" "1.440" "1.561" "1.413" "1.028" "1.619" "1.508" "1.044" "1.800" "2.712" "19.0" "27.4" "29.7" "26.8" "19.5" "30.8" "28.7" "19.8" "34.2" "51.5" "" "" "" "" "" "" "" "" "" "" "11.4" "14.2" "16.4" "12.6" "9.1" "15.8" "13.3" "8.9" "18.6" "51.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "558828740565352174" "False" "High" "IsMasterProtein" "Q2VPK5" "Cytoplasmic tRNA 2-thiolation protein 2 OS=Homo sapiens OX=9606 GN=CTU2 PE=1 SV=1" "0.001" "False" "3.706" "4" "2" "2" "2" "515" "56.1" "6.32" "3.92" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf10288" "348180" "ENSG00000174177" "CTU2" "B2RXK0; hsa:348180; Q0P511; Q2VPK5; Q66K78; Q6P4C8; Q86SV4" "" "tRNA modification in the nucleus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2363903174010187196" "False" "High" "IsMasterProtein" "Q6W2J9" "BCL-6 corepressor OS=Homo sapiens OX=9606 GN=BCOR PE=1 SV=1" "0.001" "False" "3.685" "1" "1" "1" "1" "1755" "192.1" "6.48" "2.37" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf12796, Pf15808, Pf16553" "54880" "ENSG00000183337" "BCOR" "D3DWB3; D3DWB4; hsa:54880; Q29RF6; Q6P4B6; Q6W2J9; Q7Z2K7; Q8TEB4; Q96DB3; Q9H232; Q9H233; Q9HCJ7; Q9NXF2" "Ectoderm differentiation; Pathways affected in adenoid cystic carcinoma; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3124234521907955571" "False" "High" "IsMasterProtein" "Q9NX24" "H/ACA ribonucleoprotein complex subunit 2 OS=Homo sapiens OX=9606 GN=NHP2 PE=1 SV=1" "0.001" "False" "3.681" "12" "1" "1" "1" "153" "17.2" "8.22" "2.24" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01248" "55651" "ENSG00000145912" "NHP2" "A6NKY8; hsa:55651; Q9NX24; Q9P095" "" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-728646887416176304" "False" "High" "IsMasterProtein" "Q8IYL3" "UPF0688 protein C1orf174 OS=Homo sapiens OX=9606 GN=C1orf174 PE=1 SV=2" "0.001" "False" "3.662" "7" "1" "1" "1" "243" "26.0" "6.90" "2.27" "1" "" "nucleus" "" "Pf15772" "339448" "ENSG00000198912" "C1orf174" "A8K0C8; A8MUG9; hsa:339448; Q5SR20; Q6NX36; Q8IYL3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "High" "Not Found" "Not Found" "High" "High" "High" "Not Found" "Not Found" "1" "" "514101839783017752" "False" "High" "IsMasterProtein" "Q9P021" "Cysteine-rich PDZ-binding protein OS=Homo sapiens OX=9606 GN=CRIPT PE=1 SV=1" "0.001" "False" "3.661" "11" "1" "1" "1" "101" "11.2" "9.47" "2.45" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10235" "9419" "ENSG00000119878" "CRIPT" "hsa:9419; Q9P021" "" "" "0" "0" "0.643" "0.848" "0.885" "1.055" "0.876" "1.092" "0.699" "0.912" "0.469" "36.4" "23.4" "30.8" "32.2" "38.3" "31.8" "39.7" "25.4" "33.2" "17.1" "" "" "" "" "" "" "" "" "" "" "21.8" "12.1" "17.1" "15.1" "17.8" "16.3" "18.5" "11.4" "18.0" "17.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4000962258629935056" "False" "High" "IsMasterProtein" "P62847" "Small ribosomal subunit protein eS24 OS=Homo sapiens OX=9606 GN=RPS24 PE=1 SV=1" "0.001" "False" "3.651" "11" "2" "2" "2" "133" "15.4" "10.78" "2.47" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01282" "6229" "ENSG00000138326" "RPS24" "E7EPK6; hsa:6229; P16632; P62847; Q5T0P7; Q5T0P8; Q7Z3D1" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; SARS-CoV-2 modulates host translation machinery; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8531201272546720497" "False" "High" "IsMasterProtein" "P14854" "Cytochrome c oxidase subunit 6B1 OS=Homo sapiens OX=9606 GN=COX6B1 PE=1 SV=2" "0.001" "False" "3.643" "17" "2" "2" "2" "86" "10.2" "7.05" "5.33" "2" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf02297" "1340" "ENSG00000126267" "COX6B1" "B2R5C9; hsa:1340; P14854; Q6IBL4" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "7" "0" "1.090" "1.145" "1.087" "1.226" "1.057" "1.093" "1.077" "1.073" "1.060" "238.3" "259.9" "272.9" "259.0" "292.3" "252.0" "260.5" "256.7" "255.6" "252.6" "" "" "" "" "" "" "" "" "" "" "142.6" "135.1" "151.1" "121.6" "135.5" "129.0" "121.1" "115.3" "138.7" "252.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7214058643654551286" "False" "High" "IsMasterProtein" "Q9Y3Y2" "Chromatin target of PRMT1 protein OS=Homo sapiens OX=9606 GN=CHTOP PE=1 SV=2" "0.001" "False" "3.643" "5" "1" "1" "1" "248" "26.4" "12.23" "3.76" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "nucleus" "nucleic acid binding activity" "Pf13865" "26097" "ENSG00000160679" "CHTOP" "D3DV55; hsa:26097; Q0VAQ8; Q2VPI9; Q5T7Y8; Q5T7Y9; Q5T7Z0; Q6NSM4; Q6PB28; Q8WYT9; Q9BUC5; Q9H034; Q9H2L0; Q9Y3Y2" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "3" "0" "1.341" "1.376" "1.510" "1.620" "1.019" "1.413" "2.004" "1.417" "1.216" "16.7" "22.4" "23.0" "25.2" "27.0" "17.0" "23.6" "33.4" "23.6" "20.3" "" "" "" "" "" "" "" "" "" "" "10.0" "11.6" "12.7" "11.8" "12.5" "8.7" "11.0" "15.0" "12.8" "20.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7975170816643306332" "False" "High" "IsMasterProtein" "O43543" "DNA repair protein XRCC2 OS=Homo sapiens OX=9606 GN=XRCC2 PE=1 SV=1" "0.001" "False" "3.640" "4" "1" "2" "1" "280" "31.9" "6.04" "4.95" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "7516" "ENSG00000196584" "XRCC2" "B2R925; hsa:7516; O43543" "Male infertility; Primary ovarian insufficiency" "Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2" "11" "0" "0.912" "0.975" "0.981" "0.973" "0.859" "1.062" "0.883" "1.078" "0.573" "328.6" "299.6" "320.3" "322.3" "319.6" "282.4" "349.0" "290.2" "354.1" "188.3" "" "" "" "" "" "" "" "" "" "" "196.7" "155.7" "177.4" "151.3" "148.1" "144.6" "162.3" "130.3" "192.1" "188.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7635739719901529146" "False" "High" "IsMasterProtein" "Q8TB03" "Uncharacterized protein CXorf38 OS=Homo sapiens OX=9606 GN=CXorf38 PE=1 SV=1" "0.001" "False" "3.631" "6" "2" "2" "2" "319" "36.6" "6.30" "0.00" "2" "" "" "" "Pf15112" "159013" "ENSG00000185753" "CXorf38" "B3KW28; D3DWB5; hsa:159013; Q5JPF5; Q8N941; Q8TB03" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7796576881168078978" "False" "High" "IsMasterProtein" "Q9P2R6" "Arginine-glutamic acid dipeptide repeats protein OS=Homo sapiens OX=9606 GN=RERE PE=1 SV=2" "0.001" "False" "3.627" "1" "2" "3" "2" "1566" "172.3" "7.69" "3.62" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00320, Pf01426, Pf01448, Pf03154" "473" "ENSG00000142599" "RERE" "hsa:473; O43393; O75046; O75359; Q5VXL9; Q6P6B9; Q9P2R6; Q9Y2W4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4485483695822680049" "False" "High" "IsMasterProtein" "Q9Y5R8" "Trafficking protein particle complex subunit 1 OS=Homo sapiens OX=9606 GN=TRAPPC1 PE=1 SV=1" "0.001" "False" "3.626" "7" "1" "1" "1" "145" "16.8" "9.16" "2.68" "1" "cell organization and biogenesis;transport" "non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04099" "58485" "ENSG00000170043" "TRAPPC1" "D3DTR0; hsa:58485; Q9Y5R8" "" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "3" "0" "0.830" "1.004" "0.925" "0.728" "1.123" "0.981" "0.486" "1.082" "1.639" "55.6" "46.1" "55.8" "51.4" "40.4" "62.4" "54.5" "27.0" "60.1" "91.1" "" "" "" "" "" "" "" "" "" "" "33.3" "24.0" "30.9" "24.1" "18.7" "31.9" "25.3" "12.1" "32.6" "91.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5094708502747754814" "False" "High" "IsMasterProtein" "P61313" "Large ribosomal subunit protein eL15 OS=Homo sapiens OX=9606 GN=RPL15 PE=1 SV=2" "0.001" "False" "3.626" "4" "1" "2" "1" "204" "24.1" "11.62" "7.01" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00827" "6138" "ENSG00000174748" "RPL15" "hsa:6138; P39030; P41051; P61313; Q5U0C0; Q642I1; Q6IPX6; Q8WYP2; Q96C44; Q9H2E5" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.759" "0.905" "0.870" "0.794" "0.862" "0.720" "0.798" "0.807" "0.475" "405.8" "308.0" "367.3" "353.0" "322.0" "349.9" "292.0" "323.8" "327.3" "192.6" "" "" "" "" "" "" "" "" "" "" "242.8" "160.1" "203.4" "165.7" "149.3" "179.1" "135.8" "145.4" "177.6" "192.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5091177938667012153" "False" "High" "IsMasterProtein" "P41743" "Protein kinase C iota type OS=Homo sapiens OX=9606 GN=PRKCI PE=1 SV=2" "0.001" "False" "3.625" "3" "1" "1" "1" "596" "68.2" "5.85" "3.69" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf00433, Pf00564" "5584" "ENSG00000163558" "PRKCI" "D3DNQ4; hsa:5584; P41743; Q8WW06" "Glioblastoma signaling pathways; Corticotropin-releasing hormone signaling pathway; G protein signaling pathways; VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Osteoblast differentiation and related diseases; Insulin signaling; Complement system in neuronal development and plasticity; Chronic hyperglycemia impairment of neuron function" "KEAP1-NFE2L2 pathway; Tight junction interactions; Pre-NOTCH Transcription and Translation; p75NTR recruits signalling complexes" "15" "0" "1.727" "0.883" "1.108" "1.162" "1.510" "1.168" "0.975" "1.532" "2.515" "21.4" "37.0" "18.9" "23.8" "24.9" "32.4" "25.0" "20.9" "32.8" "53.9" "" "" "" "" "" "" "" "" "" "" "12.8" "19.2" "10.5" "11.2" "11.5" "16.6" "11.6" "9.4" "17.8" "53.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7307907366133705571" "False" "High" "IsMasterProtein" "Q9UJY4" "ADP-ribosylation factor-binding protein GGA2 OS=Homo sapiens OX=9606 GN=GGA2 PE=1 SV=3" "0.001" "False" "3.624" "2" "2" "2" "1" "613" "67.1" "6.55" "5.18" "2" "transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "23062" "ENSG00000103365" "GGA2" "D3DWF0; hsa:23062; O14564; Q9NYN2; Q9UJY4; Q9UPS2" "" "Amyloid fiber formation; TBC/RABGAPs" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8009088926221679389" "False" "High" "IsMasterProtein" "P40616" "ADP-ribosylation factor-like protein 1 OS=Homo sapiens OX=9606 GN=ARL1 PE=1 SV=1" "0.001" "False" "3.623" "13" "2" "2" "2" "181" "20.4" "5.72" "0.00" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00025" "400" "ENSG00000120805" "ARL1" "B4DWW1; hsa:400; P40616; P80417; Q53XB1" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3902641514385650329" "False" "High" "IsMasterProtein" "Q5BKZ1" "DBIRD complex subunit ZNF326 OS=Homo sapiens OX=9606 GN=ZNF326 PE=1 SV=2" "0.001" "False" "3.619" "2" "1" "1" "1" "582" "65.6" "5.15" "2.89" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04988" "284695" "ENSG00000162664" "ZNF326" "A8MYX1; B4DLN0; B4E179; hsa:284695; Q5BKZ1; Q5VW93; Q5VW94; Q5VW96; Q5VW97; Q6NSA2; Q7Z638; Q7Z6C2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8230923864296422238" "False" "High" "IsMasterProtein" "Q9Y303" "N-acetylglucosamine-6-phosphate deacetylase OS=Homo sapiens OX=9606 GN=AMDHD2 PE=1 SV=2" "0.001" "False" "3.608" "2" "1" "2" "1" "409" "43.7" "6.70" "3.03" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf01979" "51005" "ENSG00000162066" "AMDHD2" "B4DL77; hsa:51005; Q8WV54; Q9Y303" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "0" "0.979" "0.970" "0.905" "1.144" "1.062" "0.881" "1.258" "0.837" "0.682" "107.5" "105.3" "104.3" "97.3" "123.0" "114.2" "94.7" "135.3" "90.1" "73.4" "" "" "" "" "" "" "" "" "" "" "64.4" "54.7" "57.8" "45.7" "57.0" "58.4" "44.0" "60.8" "48.9" "73.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7551679411334968012" "False" "High" "IsMasterProtein" "Q15649" "Zinc finger HIT domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZNHIT3 PE=1 SV=2" "0.001" "False" "3.597" "6" "1" "1" "1" "155" "17.6" "5.67" "3.52" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04438, Pf21373" "9326" "ENSG00000273611; ENSG00000278574" "ZNHIT3" "A8K493; hsa:9326; K7EQP1; Q15649; Q8WVJ3" "17q12 copy number variation syndrome" "" "1" "0" "1.113" "1.161" "1.270" "1.095" "1.080" "1.186" "1.027" "0.966" "0.765" "137.1" "152.5" "159.2" "174.1" "150.1" "148.1" "162.6" "140.7" "132.4" "104.8" "" "" "" "" "" "" "" "" "" "" "82.0" "79.3" "88.2" "81.7" "69.6" "75.8" "75.6" "63.2" "71.9" "104.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6302515266357767192" "False" "High" "IsMasterProtein" "Q9NR46" "Endophilin-B2 OS=Homo sapiens OX=9606 GN=SH3GLB2 PE=1 SV=1" "0.001" "False" "3.594" "5" "2" "2" "2" "395" "43.9" "5.99" "2.77" "2" "cell organization and biogenesis" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03114, Pf14604" "56904" "ENSG00000148341" "SH3GLB2" "A6NC47; A8MPS4; hsa:56904; Q8WY61; Q96JH9; Q9NR46" "" "" "0" "0" "1.157" "1.109" "0.969" "0.975" "1.315" "1.032" "0.675" "1.188" "6.613" "48.5" "56.1" "53.8" "47.0" "47.3" "63.8" "50.1" "32.7" "57.6" "320.8" "" "" "" "" "" "" "" "" "" "" "29.0" "29.2" "29.8" "22.1" "21.9" "32.6" "23.3" "14.7" "31.3" "320.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1363881983208351205" "False" "High" "IsMasterProtein" "Q15438" "Cytohesin-1 OS=Homo sapiens OX=9606 GN=CYTH1 PE=1 SV=1" "0.001" "False" "3.580" "5" "2" "4" "2" "398" "46.4" "5.54" "3.95" "2" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01369" "9267" "ENSG00000108669" "CYTH1" "A6NFW7; B7Z1T4; hsa:9267; Q15438; Q9P123; Q9P124" "2q37 copy number variation syndrome" "Intra-Golgi traffic" "2" "0" "0.939" "1.154" "1.179" "1.167" "0.993" "1.164" "0.862" "0.953" "1.645" "113.6" "106.7" "131.1" "133.9" "132.5" "112.7" "132.1" "97.8" "108.3" "186.8" "" "" "" "" "" "" "" "" "" "" "68.0" "55.4" "72.6" "62.9" "61.4" "57.7" "61.4" "43.9" "58.7" "186.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8973056022317677667" "False" "High" "IsMasterProtein" "Q9BVS4" "Serine/threonine-protein kinase RIO2 OS=Homo sapiens OX=9606 GN=RIOK2 PE=1 SV=2" "0.001" "False" "3.578" "4" "2" "2" "2" "552" "63.2" "5.94" "2.03" "2" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01163, Pf09202" "55781" "ENSG00000058729" "RIOK2" "D6RDI3; hsa:55781; Q9BVS4; Q9NUT0" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.357" "1.148" "1.363" "1.125" "1.117" "1.463" "1.306" "0.999" "0.590" "67.8" "92.1" "77.9" "92.4" "76.3" "75.7" "99.2" "88.6" "67.7" "40.0" "" "" "" "" "" "" "" "" "" "" "40.6" "47.8" "43.1" "43.4" "35.4" "38.8" "46.1" "39.8" "36.8" "40.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9158242191706838173" "False" "High" "IsMasterProtein" "Q71RC2" "La-related protein 4 OS=Homo sapiens OX=9606 GN=LARP4 PE=1 SV=3" "0.001" "False" "3.576" "1" "1" "1" "1" "724" "80.5" "6.61" "2.71" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf05383" "113251" "ENSG00000161813" "LARP4" "A8K6T1; E9PDG5; G3XAA8; G5E976; hsa:113251; Q5CZ97; Q6ZV14; Q71RC2; Q96NF9" "" "" "0" "0" "1.133" "1.121" "1.168" "1.220" "1.253" "1.098" "1.160" "1.203" "0.874" "43.1" "48.9" "48.4" "50.4" "52.7" "54.1" "47.4" "50.0" "51.9" "37.7" "" "" "" "" "" "" "" "" "" "" "25.8" "25.4" "26.8" "23.7" "24.4" "27.7" "22.0" "22.5" "28.2" "37.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7599147423310777868" "False" "High" "IsMasterProtein" "P55199" "RNA polymerase II elongation factor ELL OS=Homo sapiens OX=9606 GN=ELL PE=1 SV=1" "0.001" "False" "3.575" "2" "1" "1" "1" "621" "68.2" "9.33" "2.25" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07303, Pf10390" "8178" "ENSG00000105656" "ELL" "hsa:8178; P55199" "Interactome of polycomb repressive complex 2 (PRC2)" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Transcription-Coupled Nucleotide Excision Repair (TC-NER)" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "Not Found" "High" "High" "High" "High" "High" "High" "1" "" "-7480340352347879805" "False" "High" "IsMasterProtein" "Q99459" "Cell division cycle 5-like protein OS=Homo sapiens OX=9606 GN=CDC5L PE=1 SV=2" "0.001" "False" "3.575" "1" "1" "1" "1" "802" "92.2" "8.18" "2.20" "1" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11831, Pf13921" "988" "ENSG00000096401" "CDC5L" "hsa:988; Q76N46; Q99459; Q99974" "" "mRNA Splicing - Major Pathway" "1" "0" "0.879" "0.797" "0.799" "0.982" "0.972" "0.825" "0.962" "1.112" "3.352" "56.1" "49.3" "44.7" "44.8" "55.1" "54.6" "46.3" "54.0" "62.4" "188.1" "" "" "" "" "" "" "" "" "" "" "33.6" "25.6" "24.8" "21.1" "25.5" "27.9" "21.5" "24.2" "33.9" "188.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6104257487773187704" "False" "High" "IsMasterProtein" "Q0PNE2" "Elongator complex protein 6 OS=Homo sapiens OX=9606 GN=ELP6 PE=1 SV=1" "0.001" "False" "3.569" "6" "2" "2" "2" "266" "29.8" "6.84" "5.08" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf09807" "54859" "ENSG00000163832" "ELP6" "hsa:54859; Q0PNE2; Q9BW57; Q9NXJ3" "" "HATs acetylate histones" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1272084248319891202" "False" "High" "IsMasterProtein" "Q9UKB1" "F-box/WD repeat-containing protein 11 OS=Homo sapiens OX=9606 GN=FBXW11 PE=1 SV=1" "0.001" "False" "3.549" "2" "1" "1" "1" "542" "62.1" "7.12" "4.13" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf12125, Pf12937" "23291" "ENSG00000072803" "FBXW11" "B2RC98; hsa:23291; Q9P2S8; Q9P2S9; Q9UKB1; Q9Y4C6" "TNF-alpha signaling pathway; VEGFA-VEGFR2 signaling" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Neddylation; Regulation of PLK1 Activity at G2/M Transition; MAP3K8 (TPL2)-dependent MAPK1/3 activation" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8809739148280005605" "False" "High" "IsMasterProtein" "P46776" "Large ribosomal subunit protein uL15 OS=Homo sapiens OX=9606 GN=RPL27A PE=1 SV=2" "0.001" "False" "3.546" "7" "1" "1" "1" "148" "16.6" "11.00" "3.07" "1" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "other molecular function" "Pf00828" "6157" "ENSG00000166441" "RPL27A" "B2R4B3; hsa:6157; P46776" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Protein hydroxylation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8248162455227524541" "False" "High" "IsMasterProtein" "Q92636" "Protein FAN OS=Homo sapiens OX=9606 GN=NSMAF PE=1 SV=2" "0.001" "False" "3.542" "1" "1" "1" "1" "917" "104.3" "6.23" "3.40" "1" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00400, Pf02138, Pf02893" "8439" "ENSG00000035681" "NSMAF" "B4DFB0; E9PCH0; hsa:8439; Q8IW26; Q92636" "TNF-alpha signaling pathway; Orexin receptor pathway" "TNFR1-mediated ceramide production" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4861296984398641120" "False" "High" "IsMasterProtein" "P34910" "Protein EVI2B OS=Homo sapiens OX=9606 GN=EVI2B PE=1 SV=2" "0.001" "False" "3.541" "3" "1" "1" "1" "448" "48.6" "4.83" "2.21" "1" "other biological processes" "plasma membrane;other membranes" "" "" "2124" "ENSG00000185862; ENSG00000291721" "EVI2B" "B7Z4A7; hsa:2124; P34910" "NF1 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1624029487017367107" "False" "High" "IsMasterProtein" "Q9C005" "Protein dpy-30 homolog OS=Homo sapiens OX=9606 GN=DPY30 PE=1 SV=1" "0.001" "False" "3.528" "9" "1" "1" "1" "99" "11.2" "4.88" "3.42" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport" "ER/Golgi;nucleus" "other molecular function" "Pf05186" "84661" "ENSG00000162961" "DPY30" "D6W578; hsa:84661; Q9C005" "Kleefstra syndrome" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Formation of WDR5-containing histone-modifying complexes" "5" "0" "0.892" "0.897" "0.909" "1.043" "0.872" "1.096" "1.069" "0.961" "0.738" "354.1" "316.0" "317.6" "321.7" "369.5" "308.9" "388.2" "378.7" "340.2" "261.5" "" "" "" "" "" "" "" "" "" "" "211.9" "164.2" "175.9" "151.1" "171.3" "158.1" "180.5" "170.0" "184.5" "261.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7253720687934924150" "False" "High" "IsMasterProtein" "P19525" "Interferon-induced, double-stranded RNA-activated protein kinase OS=Homo sapiens OX=9606 GN=EIF2AK2 PE=1 SV=2" "0.001" "False" "3.525" "2" "1" "1" "1" "551" "62.1" "8.40" "2.95" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00035, Pf00069" "5610" "ENSG00000055332" "EIF2AK2" "A8K3P0; D6W584; E9PC80; hsa:5610; P19525; Q52M43; Q7Z6F6; Q9UIR4" "Translation factors; Alzheimer's disease and miRNA effects; PDGFR-beta pathway; Ebola virus infection in host; Measles virus infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Alzheimer's disease; Roles of ceramides in development of insulin resistance; Type II interferon signaling" "ISG15 antiviral mechanism; PKR-mediated signaling; Interferon alpha/beta signaling; Evasion by RSV of host interferon responses; Inhibition of PKR; SUMOylation of immune response proteins" "16" "0" "1.419" "1.248" "1.721" "1.548" "1.053" "1.159" "1.489" "1.261" "2.514" "27.3" "38.8" "34.1" "47.1" "42.3" "28.8" "31.7" "40.7" "34.5" "68.8" "" "" "" "" "" "" "" "" "" "" "16.4" "20.2" "18.9" "22.1" "19.6" "14.7" "14.7" "18.3" "18.7" "68.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4536625609042411990" "False" "High" "IsMasterProtein" "Q16656" "Nuclear respiratory factor 1 OS=Homo sapiens OX=9606 GN=NRF1 PE=1 SV=1" "0.001" "False" "3.522" "2" "1" "2" "1" "503" "53.5" "5.05" "4.89" "1" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf10491" "4899" "ENSG00000106459" "NRF1" "A8K4C6; B4DDV6; hsa:4899; Q15305; Q16656; Q96AN2" "Energy metabolism; Interactions between LOXL4 and oxidative stress pathway; Mitochondrial gene expression; Sildenafil treatment" "PPARA activates gene expression; Transcriptional activation of mitochondrial biogenesis" "6" "0" "0.964" "1.121" "1.387" "1.280" "1.343" "0.892" "1.107" "1.035" "1.896" "39.4" "38.0" "44.2" "54.7" "50.5" "52.9" "35.2" "43.6" "40.8" "74.7" "" "" "" "" "" "" "" "" "" "" "23.6" "19.7" "24.5" "25.7" "23.4" "27.1" "16.3" "19.6" "22.1" "74.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4996953049836216410" "False" "High" "IsMasterProtein" "O14618" "Copper chaperone for superoxide dismutase OS=Homo sapiens OX=9606 GN=CCS PE=1 SV=1" "0.001" "False" "3.521" "5" "2" "2" "2" "274" "29.0" "5.58" "4.30" "2" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00080, Pf00403" "9973" "ENSG00000173992" "CCS" "hsa:9973; O14618; Q2M366; Q8NEV0" "Amyotrophic lateral sclerosis (ALS); Copper homeostasis" "Detoxification of Reactive Oxygen Species" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-163153293796965969" "False" "High" "IsMasterProtein" "Q9NWB6" "Arginine and glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=ARGLU1 PE=1 SV=1" "0.001" "False" "3.520" "5" "2" "3" "2" "273" "33.2" "10.35" "4.51" "2" "" "cytosol;mitochondrion;nucleus" "" "Pf15346" "55082" "ENSG00000134884" "ARGLU1" "B4E0Y3; hsa:55082; Q5T257; Q6IQ34; Q9NWB6" "" "" "0" "0" "1.129" "0.963" "1.102" "1.184" "0.871" "1.407" "1.237" "0.968" "0.778" "140.3" "158.4" "135.1" "154.6" "166.2" "122.2" "197.3" "173.5" "135.8" "109.1" "" "" "" "" "" "" "" "" "" "" "84.0" "82.3" "74.8" "72.6" "77.0" "62.5" "91.8" "77.9" "73.7" "109.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-221730190353322517" "False" "High" "IsMasterProtein" "Q9UL63" "Muskelin OS=Homo sapiens OX=9606 GN=MKLN1 PE=1 SV=2" "0.001" "False" "3.510" "1" "1" "1" "1" "735" "84.7" "6.34" "2.63" "1" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01344, Pf06588, Pf13415" "4289" "ENSG00000128585" "MKLN1" "A4D1M8; A6NG43; hsa:4289; Q9NSK4; Q9NUS8; Q9UL63" "Ciliary landscape" "" "1" "0" "1.233" "1.074" "1.056" "1.292" "0.880" "1.183" "0.863" "1.290" "1.771" "25.0" "30.9" "26.9" "26.4" "32.4" "22.0" "29.6" "21.6" "32.3" "44.4" "" "" "" "" "" "" "" "" "" "" "15.0" "16.1" "14.9" "12.4" "15.0" "11.3" "13.8" "9.7" "17.5" "44.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7633283186484640293" "False" "High" "IsMasterProtein" "Q06547" "GA-binding protein subunit beta-1 OS=Homo sapiens OX=9606 GN=GABPB1 PE=1 SV=2" "0.001" "False" "3.509" "2" "1" "1" "1" "395" "42.5" "4.86" "2.91" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf12796" "2553" "ENSG00000104064" "GABPB1" "A8IE52; hsa:2553; Q06545; Q06547; Q12940; Q12941; Q12942; Q8IYD0" "Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-577333653668623519" "False" "High" "IsMasterProtein" "Q9HAD4" "WD repeat-containing protein 41 OS=Homo sapiens OX=9606 GN=WDR41 PE=1 SV=3" "0.001" "False" "3.506" "3" "1" "1" "1" "459" "51.7" "5.44" "2.46" "1" "other metabolic processes;other biological processes" "other cell component" "" "Pf00400" "55255" "ENSG00000164253" "WDR41" "B4DT55; hsa:55255; Q7Z792; Q8IWG3; Q8IXA9; Q8NDA7; Q9HAD4; Q9NV62" "" "" "0" "0" "1.390" "1.238" "0.855" "1.287" "1.500" "1.343" "1.172" "1.031" "1.268" "23.3" "32.3" "28.8" "19.9" "29.9" "34.9" "31.2" "27.3" "24.0" "29.5" "" "" "" "" "" "" "" "" "" "" "13.9" "16.8" "15.9" "9.3" "13.9" "17.9" "14.5" "12.2" "13.0" "29.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2007854671863603578" "False" "High" "IsMasterProtein" "P46734" "Dual specificity mitogen-activated protein kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP2K3 PE=1 SV=2" "0.001" "False" "3.493" "4" "1" "1" "1" "347" "39.3" "7.43" "2.44" "1" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5606" "ENSG00000034152" "MAP2K3" "B3KSK7; hsa:5606; P46734; Q99441; Q9UE71; Q9UE72" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Endoderm differentiation; Photodynamic therapy-induced AP-1 survival signaling; TGF-beta signaling pathway; MAPK signaling pathway; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; 16p11.2 proximal deletion syndrome; Pleural mesothelioma; GNAQ pathways in port-wine stain; Interferon type I signaling pathways; Serotonin HTR1 group and FOS pathway; Toll-like receptor signaling pathway" "Oxidative Stress Induced Senescence; activated TAK1 mediates p38 MAPK activation" "34" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5858537743821975597" "False" "High" "IsMasterProtein" "O75843" "AP-1 complex subunit gamma-like 2 OS=Homo sapiens OX=9606 GN=AP1G2 PE=1 SV=1" "0.001" "False" "3.493" "2" "2" "2" "1" "785" "87.1" "6.55" "2.41" "2" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf01602, Pf02883" "8906" "ENSG00000213983" "AP1G2" "D3DS51; hsa:8906; O75504; O75843" "" "Lysosome Vesicle Biogenesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2556880978610824670" "False" "High" "IsMasterProtein" "P62256" "Ubiquitin-conjugating enzyme E2 H OS=Homo sapiens OX=9606 GN=UBE2H PE=1 SV=1" "0.001" "False" "3.493" "4" "1" "1" "1" "183" "20.6" "4.67" "3.48" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179" "7328" "ENSG00000186591" "UBE2H" "A4D1L6; C9JY93; hsa:7328; P37286; P62256; Q7Z6F4" "Ciliary landscape" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "3" "0" "1.040" "1.124" "0.799" "0.991" "0.935" "0.834" "0.819" "0.994" "1.137" "180.9" "188.2" "203.4" "144.5" "179.3" "169.1" "150.9" "148.1" "179.8" "205.8" "" "" "" "" "" "" "" "" "" "" "108.3" "97.8" "112.6" "67.9" "83.1" "86.6" "70.2" "66.5" "97.5" "205.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7820543804174258540" "False" "High" "IsMasterProtein" "P00374" "Dihydrofolate reductase OS=Homo sapiens OX=9606 GN=DHFR PE=1 SV=2" "0.001" "False" "3.492" "8" "2" "6" "2" "187" "21.4" "7.42" "10.86" "2" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00186" "1719" "ENSG00000228716" "DHFR" "B4DDD2; hsa:1719; P00374; Q14130; Q6IRW8" "Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration, one-carbon metabolism and related pathways; Ethanol effects on histone modifications" "G1/S-Specific Transcription; Metabolism of folate and pterines; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "9" "0" "1.042" "1.235" "1.191" "1.267" "1.043" "1.288" "0.312" "1.254" "8.838" "138.4" "144.3" "171.0" "164.8" "175.3" "144.3" "178.3" "43.1" "173.6" "1223.3" "" "" "" "" "" "" "" "" "" "" "82.8" "75.0" "94.7" "77.4" "81.3" "73.9" "82.9" "19.4" "94.2" "1223.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-72385411951020745" "False" "High" "IsMasterProtein" "Q5VUM1" "Succinate dehydrogenase assembly factor 4, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF4 PE=1 SV=1" "0.001" "False" "3.491" "10" "1" "2" "1" "108" "12.2" "9.36" "3.26" "1" "cell organization and biogenesis;other metabolic processes;stress response" "mitochondrion" "enzyme regulator activity" "Pf07896" "135154" "ENSG00000154079" "SDHAF4" "E1P532; hsa:135154; Q5VUM1" "Mitochondrial complex II assembly" "" "1" "0" "1.166" "1.255" "1.254" "1.303" "1.186" "1.002" "1.257" "1.220" "0.627" "105.8" "123.4" "132.8" "132.7" "137.9" "125.5" "106.0" "133.0" "129.1" "66.3" "" "" "" "" "" "" "" "" "" "" "63.3" "64.1" "73.6" "62.3" "63.9" "64.2" "49.3" "59.7" "70.0" "66.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-155447427223618220" "False" "High" "IsMasterProtein" "A6NFY7" "Succinate dehydrogenase assembly factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF1 PE=1 SV=1" "0.001" "False" "3.473" "14" "1" "1" "1" "115" "12.8" "11.39" "0.00" "1" "cell organization and biogenesis" "mitochondrion;nucleus" "" "Pf05347" "644096" "ENSG00000205138" "SDHAF1" "A6NFY7; B2RPM7; hsa:644096" "Mitochondrial complex II assembly" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "High" "High" "Not Found" "Not Found" "High" "Not Found" "High" "High" "1" "" "-1530095289376032453" "False" "High" "IsMasterProtein" "Q9HBH1" "Peptide deformylase, mitochondrial OS=Homo sapiens OX=9606 GN=PDF PE=1 SV=1" "0.001" "False" "3.470" "4" "1" "1" "1" "243" "27.0" "9.16" "3.57" "1" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf01327" "64146" "ENSG00000258429" "PDF" "hsa:64146; Q8WUN6; Q9HBH1" "" "" "0" "0" "0.973" "0.929" "0.973" "1.007" "0.987" "1.072" "0.882" "0.949" "0.665" "122.0" "118.7" "113.3" "118.6" "122.9" "120.4" "130.7" "107.6" "115.7" "81.1" "" "" "" "" "" "" "" "" "" "" "73.0" "61.7" "62.7" "55.7" "56.9" "61.6" "60.8" "48.3" "62.8" "81.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1419370867446709471" "False" "High" "IsMasterProtein" "P42677" "Small ribosomal subunit protein eS27 OS=Homo sapiens OX=9606 GN=RPS27 PE=1 SV=3" "0.001" "False" "3.465" "13" "1" "1" "1" "84" "9.5" "9.45" "3.44" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01667" "6232" "ENSG00000177954" "RPS27" "hsa:6232; P42677; Q5T4L6" "Cytoplasmic ribosomal proteins" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "25" "0" "1.077" "1.277" "0.990" "1.164" "1.081" "1.014" "0.899" "0.927" "1.188" "60.7" "65.4" "77.6" "60.1" "70.7" "65.7" "61.6" "54.6" "56.3" "72.2" "" "" "" "" "" "" "" "" "" "" "36.3" "34.0" "43.0" "28.2" "32.8" "33.6" "28.6" "24.5" "30.6" "72.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7388585802174213380" "False" "High" "IsMasterProtein" "Q06187" "Tyrosine-protein kinase BTK OS=Homo sapiens OX=9606 GN=BTK PE=1 SV=3" "0.001" "False" "3.463" "3" "2" "2" "2" "659" "76.2" "7.77" "4.86" "2" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf00169, Pf00779, Pf07714" "695" "ENSG00000010671" "BTK" "B2RAW1; hsa:695; Q06187; Q32ML5" "IL-5 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; Kit receptor signaling pathway; 7q11.23 copy number variation syndrome; Genetic causes of porto-sinusoidal vascular disease" "FCGR3A-mediated phagocytosis; ER-Phagosome pathway; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated Ca+2 mobilization; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; G alpha (12/13) signalling events; G alpha (q) signalling events; RHO GTPases Activate WASPs and WAVEs; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); DAP12 signaling; G beta:gamma signalling through BTK" "20" "0" "1.311" "1.384" "1.144" "1.559" "0.949" "0.894" "0.434" "1.201" "10.495" "26.6" "34.9" "36.9" "30.5" "41.5" "25.3" "23.8" "11.6" "32.0" "279.5" "" "" "" "" "" "" "" "" "" "" "15.9" "18.1" "20.4" "14.3" "19.2" "12.9" "11.1" "5.2" "17.4" "279.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-200305812606160804" "False" "High" "IsMasterProtein" "Q3MHD2" "Protein LSM12 OS=Homo sapiens OX=9606 GN=LSM12 PE=1 SV=2" "0.001" "False" "3.461" "5" "1" "2" "1" "195" "21.7" "7.74" "3.76" "1" "" "other cell component" "nucleic acid binding activity" "Pf09793, Pf21166" "124801" "ENSG00000161654" "LSM12" "hsa:124801; Q3MHD2; Q86YB1; Q96NL5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8757061134285989517" "False" "High" "IsMasterProtein" "Q13586" "Stromal interaction molecule 1 OS=Homo sapiens OX=9606 GN=STIM1 PE=1 SV=3" "0.001" "False" "3.451" "2" "1" "1" "1" "685" "77.4" "6.67" "3.41" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi" "cytoskeletal activity;other molecular function" "Pf07647, Pf16533" "6786" "ENSG00000167323" "STIM1" "E9PQJ4; hsa:6786; Q13586; Q8N382" "CAMKK2 pathway; Affected pathways in Duchenne muscular dystrophy" "Ion homeostasis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Elevation of cytosolic Ca2+ levels" "5" "0" "1.379" "1.114" "1.233" "1.553" "1.347" "1.724" "1.807" "1.549" "1.692" "29.8" "41.1" "33.2" "36.8" "46.3" "40.2" "51.4" "53.9" "46.2" "50.5" "" "" "" "" "" "" "" "" "" "" "17.9" "21.4" "18.4" "17.3" "21.5" "20.6" "23.9" "24.2" "25.1" "50.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2091961222017639990" "False" "High" "IsMasterProtein" "Q13123" "Protein Red OS=Homo sapiens OX=9606 GN=IK PE=1 SV=3" "0.001" "False" "3.450" "3" "2" "2" "2" "557" "65.6" "6.64" "1.77" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07807, Pf07808" "3550" "ENSG00000113141" "IK" "hsa:3550; Q13123; Q6IPD8" "" "mRNA Splicing - Major Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2136811018986940550" "False" "High" "IsMasterProtein" "Q9NS91" "E3 ubiquitin-protein ligase RAD18 OS=Homo sapiens OX=9606 GN=RAD18 PE=1 SV=2" "0.001" "False" "3.449" "2" "1" "1" "1" "495" "56.2" "7.58" "2.80" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf13923" "56852" "ENSG00000070950" "RAD18" "Q58F55; Q9NRT6; Q9NS91" "SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome" "E3 ubiquitin ligases ubiquitinate target proteins; Recognition of DNA damage by PCNA-containing replication complex" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3895404278384693276" "False" "High" "IsMasterProtein" "P08047" "Transcription factor Sp1 OS=Homo sapiens OX=9606 GN=SP1 PE=1 SV=3" "0.001" "False" "3.441" "1" "1" "2" "1" "785" "80.6" "7.34" "5.29" "1" "stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6667" "ENSG00000185591" "SP1" "E4Z9M7; G5E9M8; hsa:6667; P08047; Q86TN8; Q9H3Q5; Q9NR51; Q9NY21; Q9NYE7" "Androgen receptor signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; IL-17 signaling pathway; Androgen receptor network in prostate cancer; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Constitutive androstane receptor pathway; Estrogen receptor pathway; Nuclear receptors meta-pathway; Myometrial relaxation and contraction pathways; Copper homeostasis; Initiation of transcription and translation elongation at the HIV-1 LTR; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; Mitochondrial gene expression; Oxidative stress response; Breast cancer pathway; Ethanol metabolism production of ROS by CYP2E1; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Gastrin signaling pathway; IL-18 signaling pathway; Angiotensin II receptor type 1 pathway; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; Genetic causes of porto-sinusoidal vascular disease; HDAC6 interactions in the central nervous system; Pathways in cancer; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway" "PPARA activates gene expression; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Oncogene Induced Senescence; Activation of gene expression by SREBF (SREBP); SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Regulation of CDH11 gene transcription; NFE2L2 regulating tumorigenic genes" "42" "0" "1.620" "1.457" "1.362" "1.717" "2.187" "1.344" "2.251" "1.428" "1.853" "15.3" "24.7" "22.2" "20.8" "26.2" "33.4" "20.5" "34.4" "21.8" "28.3" "" "" "" "" "" "" "" "" "" "" "9.1" "12.9" "12.3" "9.8" "12.2" "17.1" "9.5" "15.4" "11.8" "28.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4278249940828633973" "False" "High" "IsMasterProtein" "P32321" "Deoxycytidylate deaminase OS=Homo sapiens OX=9606 GN=DCTD PE=1 SV=2" "0.001" "False" "3.435" "6" "1" "1" "1" "178" "20.0" "7.56" "2.51" "1" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00383" "1635" "ENSG00000129187" "DCTD" "B2R836; D3DP49; D3DP50; hsa:1635; P32321; Q5M7Z8; Q9BVD8" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6863888683684881853" "False" "High" "IsMasterProtein" "Q9NZG7" "Ninjurin-2 OS=Homo sapiens OX=9606 GN=NINJ2 PE=1 SV=1" "0.001" "False" "3.427" "9" "1" "1" "1" "142" "15.7" "9.52" "2.34" "1" "cell adhesion;developmental processes;other biological processes" "plasma membrane;other membranes" "" "Pf04923" "4815" "ENSG00000171840" "NINJ2" "hsa:4815; Q9NZG7" "" "" "0" "0" "0.927" "0.807" "0.909" "0.927" "1.020" "0.798" "0.935" "1.061" "0.377" "46.5" "43.1" "37.5" "42.2" "43.1" "47.4" "37.0" "43.5" "49.3" "17.5" "" "" "" "" "" "" "" "" "" "" "27.8" "22.4" "20.8" "19.8" "20.0" "24.2" "17.2" "19.5" "26.7" "17.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8612473288009054962" "False" "High" "IsMasterProtein" "Q16626" "Male-enhanced antigen 1 OS=Homo sapiens OX=9606 GN=MEA1 PE=1 SV=2" "0.001" "False" "3.423" "9" "1" "1" "1" "185" "19.9" "4.22" "2.68" "1" "developmental processes;other biological processes" "other cell component" "" "Pf06910" "4201" "ENSG00000124733" "MEA1" "hsa:4201; Q16626; Q5TC36; Q9BV01" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4848628119440074227" "False" "High" "IsMasterProtein" "P30038" "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH4A1 PE=1 SV=3" "0.001" "False" "3.400" "1" "1" "1" "1" "563" "61.7" "8.07" "3.44" "1" "other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00171" "8659" "ENSG00000159423" "ALDH4A1" "A8K1Q7; B4DGE4; D2D4A3; hsa:8659; P30038; Q16882; Q53HU4; Q5JNV6; Q8IZ38; Q96IF0; Q9UDI6" "22q11.2 copy number variation syndrome; p53 transcriptional gene network" "Glyoxylate metabolism and glycine degradation; Proline catabolism" "4" "0" "0.866" "0.813" "1.000" "0.964" "0.996" "0.942" "0.798" "1.180" "1.249" "87.1" "75.4" "70.8" "87.1" "83.9" "86.7" "82.0" "69.5" "102.8" "108.7" "" "" "" "" "" "" "" "" "" "" "52.1" "39.2" "39.2" "40.9" "38.9" "44.4" "38.1" "31.2" "55.8" "108.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1418350428187629844" "False" "High" "IsMasterProtein" "O43678" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 OS=Homo sapiens OX=9606 GN=NDUFA2 PE=1 SV=3" "0.001" "False" "3.387" "9" "1" "1" "1" "99" "10.9" "9.57" "3.36" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "other membranes;mitochondrion" "transporter activity" "Pf05047" "4695" "ENSG00000131495" "NDUFA2" "D6RJD6; hsa:4695; O43678; Q6IAY8" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis; Mitochondrial protein degradation" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8105981666538771075" "False" "High" "IsMasterProtein" "P80297" "Metallothionein-1X OS=Homo sapiens OX=9606 GN=MT1X PE=1 SV=1" "0.001" "False" "3.386" "13" "1" "1" "1" "61" "6.1" "7.96" "3.26" "1" "stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00131" "4501" "ENSG00000187193" "MT1X" "A8MUC7; hsa:4501; P80297" "Copper homeostasis; Zinc homeostasis; Oxidative stress response" "Metallothioneins bind metals" "4" "0" "1.298" "1.361" "1.189" "1.052" "1.098" "1.452" "1.435" "1.130" "0.740" "90.4" "117.3" "123.0" "107.5" "95.1" "99.2" "131.2" "129.7" "102.1" "66.9" "" "" "" "" "" "" "" "" "" "" "54.1" "61.0" "68.1" "50.4" "44.1" "50.8" "61.0" "58.2" "55.4" "66.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4707319533501773453" "False" "High" "IsMasterProtein" "O95260" "Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=2" "0.001" "False" "3.383" "2" "1" "1" "1" "518" "59.1" "7.93" "2.34" "1" "protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04376, Pf04377" "11101" "ENSG00000107669" "ATE1" "hsa:11101; O95260; O95261; Q5SQQ3; Q8WW04" "" "" "0" "0" "0.909" "0.974" "0.790" "0.832" "1.086" "1.212" "1.010" "0.900" "1.894" "45.5" "41.3" "44.3" "35.9" "37.8" "49.4" "55.1" "45.9" "40.9" "86.2" "" "" "" "" "" "" "" "" "" "" "27.2" "21.5" "24.5" "16.9" "17.5" "25.3" "25.6" "20.6" "22.2" "86.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1422761924457517511" "False" "High" "IsMasterProtein" "A3KN83" "Protein strawberry notch homolog 1 OS=Homo sapiens OX=9606 GN=SBNO1 PE=1 SV=1" "0.001" "False" "3.381" "2" "2" "2" "2" "1393" "154.2" "7.88" "0.00" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13871, Pf13872" "55206" "ENSG00000139697" "SBNO1" "A3KN83; Q05C06; Q3ZTS3; Q9H3T8; Q9NVB2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7331601319371966852" "False" "High" "IsMasterProtein" "P21964" "Catechol O-methyltransferase OS=Homo sapiens OX=9606 GN=COMT PE=1 SV=2" "0.001" "False" "3.376" "3" "1" "1" "1" "271" "30.0" "5.47" "2.85" "1" "cell-cell signaling;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01596" "1312" "ENSG00000093010" "COMT" "A8MPV9; hsa:1312; P21964; Q6IB07; Q6ICE6; Q9BWC7" "Dopamine metabolism; Flavan-3-ol metabolic pathway; MTHFR deficiency; 22q11.2 copy number variation syndrome; Primary ovarian insufficiency; Biogenic amine synthesis; Estrogen metabolism; Metapathway biotransformation Phase I and II; Methylation pathways" "Potential therapeutics for SARS; Methylation; Enzymatic degradation of dopamine by COMT; Enzymatic degradation of Dopamine by monoamine oxidase" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8144210320745121937" "False" "High" "IsMasterProtein" "Q5T1J5" "Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial OS=Homo sapiens OX=9606 GN=CHCHD2P9 PE=5 SV=1" "0.001" "False" "3.374" "9" "1" "1" "1" "151" "15.5" "9.89" "3.52" "1" "cell organization and biogenesis;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity" "" "" "" "CHCHD2P9" "Q5T1J5" "" "" "0" "0" "0.787" "0.998" "1.094" "1.030" "1.139" "1.294" "1.169" "1.131" "0.704" "77.7" "61.2" "77.5" "85.1" "80.0" "88.5" "100.6" "90.9" "87.9" "54.7" "" "" "" "" "" "" "" "" "" "" "46.5" "31.8" "42.9" "39.9" "37.1" "45.3" "46.8" "40.8" "47.7" "54.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3838187860165332500" "False" "High" "IsMasterProtein" "P52564" "Dual specificity mitogen-activated protein kinase kinase 6 OS=Homo sapiens OX=9606 GN=MAP2K6 PE=1 SV=1" "0.001" "False" "3.360" "4" "1" "1" "1" "334" "37.5" "7.39" "2.25" "1" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5608" "ENSG00000108984" "MAP2K6" "hsa:5608; P52564" "MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Photodynamic therapy-induced AP-1 survival signaling; TGF-beta signaling pathway; MAPK signaling pathway; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; p38 MAPK signaling pathway; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; 16p11.2 proximal deletion syndrome; Angiotensin II receptor type 1 pathway; Pleural mesothelioma; GNAQ pathways in port-wine stain; Interferon type I signaling pathways; Serotonin HTR1 group and FOS pathway; Toll-like receptor signaling pathway" "PKR-mediated signaling; Interleukin-1 signaling; Oxidative Stress Induced Senescence; Myogenesis; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; PI5P Regulates TP53 Acetylation" "41" "0" "1.179" "1.021" "1.192" "1.055" "1.380" "1.123" "1.004" "1.102" "0.712" "52.2" "61.5" "53.3" "62.2" "55.0" "72.0" "58.6" "52.4" "57.5" "37.1" "" "" "" "" "" "" "" "" "" "" "31.2" "32.0" "29.5" "29.2" "25.5" "36.9" "27.3" "23.5" "31.2" "37.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "983128830238586266" "False" "High" "IsMasterProtein" "Q53F19" "Nuclear cap-binding protein subunit 3 OS=Homo sapiens OX=9606 GN=NCBP3 PE=1 SV=2" "0.002" "False" "3.341" "3" "2" "2" "2" "620" "70.5" "5.73" "3.59" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf10309" "55421" "ENSG00000074356" "NCBP3" "B3KWG7; hsa:55421; Q53F19; Q7L406; Q96FK1; Q9NXZ4" "" "" "0" "0" "1.450" "1.316" "1.311" "1.296" "1.325" "1.151" "1.139" "1.174" "3.129" "43.5" "63.1" "57.2" "57.0" "56.4" "57.6" "50.1" "49.5" "51.1" "136.1" "" "" "" "" "" "" "" "" "" "" "26.0" "32.8" "31.7" "26.8" "26.1" "29.5" "23.3" "22.2" "27.7" "136.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5647730209445312513" "False" "High" "IsMasterProtein" "Q9BWT3" "Poly(A) polymerase gamma OS=Homo sapiens OX=9606 GN=PAPOLG PE=1 SV=2" "0.002" "False" "3.338" "3" "2" "2" "1" "736" "82.8" "9.14" "2.24" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf04926, Pf04928, Pf20750" "64895" "ENSG00000115421" "PAPOLG" "B2RBH4; hsa:64895; Q59G05; Q969N1; Q9BWT3; Q9H8L2; Q9HAD0" "" "" "0" "1" "0.633" "0.736" "0.487" "0.411" "0.740" "0.607" "0.506" "0.624" "1.777" "105.6" "66.9" "77.8" "51.4" "43.5" "78.2" "64.1" "53.4" "65.9" "187.7" "" "" "" "" "" "" "" "" "" "" "63.2" "34.8" "43.1" "24.1" "20.1" "40.0" "29.8" "24.0" "35.8" "187.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "117675378851989584" "False" "High" "IsMasterProtein" "P56270" "Myc-associated zinc finger protein OS=Homo sapiens OX=9606 GN=MAZ PE=1 SV=1" "0.002" "False" "3.336" "2" "1" "1" "1" "477" "48.6" "8.95" "2.66" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13894" "4150" "ENSG00000103495" "MAZ" "A8QJL9; C6G496; G5E927; H3BQD6; hsa:4150; P56270; Q15703; Q8NFN7; Q99443" "16p11.2 proximal deletion syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6452221919959736930" "False" "High" "IsMasterProtein" "O75122" "CLIP-associating protein 2 OS=Homo sapiens OX=9606 GN=CLASP2 PE=1 SV=3" "0.002" "False" "3.334" "1" "1" "1" "1" "1294" "141.0" "8.40" "2.82" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf12348, Pf21040" "23122" "ENSG00000163539" "CLASP2" "B2RTR1; F5H604; hsa:23122; O75122; Q7L8F6; Q8N6R6; Q9BQT3; Q9BQT4; Q9H7A3; Q9NSZ2" "7q11.23 copy number variation syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Role of ABL in ROBO-SLIT signaling" "8" "0" "1.136" "0.987" "1.093" "0.894" "0.957" "1.378" "1.511" "0.647" "4.546" "24.1" "27.4" "23.8" "26.3" "21.5" "23.1" "33.2" "36.4" "15.6" "109.5" "" "" "" "" "" "" "" "" "" "" "14.4" "14.2" "13.2" "12.4" "10.0" "11.8" "15.4" "16.3" "8.5" "109.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1697211468385276031" "False" "High" "IsMasterProtein" "P62861" "Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein OS=Homo sapiens OX=9606 GN=FAU PE=1 SV=2" "0.002" "False" "3.331" "8" "1" "4" "1" "133" "14.4" "10.17" "3.96" "1" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00240, Pf04758" "2197" "ENSG00000149806" "FAU" "hsa:2197; P35544; P62861; Q05472; Q95261; Q9H5V4" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "0.978" "1.093" "0.921" "0.978" "0.820" "1.029" "0.886" "1.022" "0.224" "50.4" "49.3" "55.1" "46.4" "49.3" "41.3" "51.8" "44.6" "51.5" "11.3" "" "" "" "" "" "" "" "" "" "" "30.2" "25.6" "30.5" "21.8" "22.8" "21.1" "24.1" "20.0" "27.9" "11.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8586542513876721198" "False" "High" "IsMasterProtein" "O43502" "DNA repair protein RAD51 homolog 3 OS=Homo sapiens OX=9606 GN=RAD51C PE=1 SV=1" "0.002" "False" "3.325" "3" "1" "1" "1" "376" "42.2" "6.74" "1.77" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "5889" "ENSG00000108384" "RAD51C" "hsa:5889; O43502; O43503; Q3B783" "DNA repair pathways, full network" "Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4788954663334132438" "False" "High" "IsMasterProtein" "Q9NWX6" "Probable tRNA(His) guanylyltransferase OS=Homo sapiens OX=9606 GN=THG1L PE=1 SV=2" "0.002" "False" "3.322" "4" "1" "2" "1" "298" "34.8" "8.00" "4.11" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response" "other membranes;cytosol;mitochondrion;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf04446, Pf14413" "54974" "ENSG00000113272" "THG1L" "D3DQJ5; hsa:54974; Q53G12; Q7L5R3; Q9H0S2; Q9NWX6" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.930" "1.206" "1.013" "0.936" "0.969" "0.888" "0.939" "1.202" "0.660" "58.9" "54.8" "71.0" "59.7" "55.1" "57.1" "52.3" "55.3" "70.8" "38.9" "" "" "" "" "" "" "" "" "" "" "35.3" "28.5" "39.3" "28.0" "25.6" "29.2" "24.3" "24.8" "38.4" "38.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3321226471008760" "False" "High" "IsMasterProtein" "Q9Y2Q3" "Glutathione S-transferase kappa 1 OS=Homo sapiens OX=9606 GN=GSTK1 PE=1 SV=3" "0.002" "False" "3.317" "7" "1" "1" "1" "226" "25.5" "8.41" "2.72" "1" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf01323" "373156" "ENSG00000197448" "GSTK1" "B4DIH1; B4DSY2; hsa:373156; Q6P4H0; Q7Z520; Q9P1S4; Q9Y2Q3" "Metapathway biotransformation Phase I and II" "Peroxisomal protein import; Glutathione conjugation" "3" "0" "0.776" "1.113" "1.025" "1.150" "1.082" "1.168" "0.961" "0.885" "2.144" "14.9" "11.6" "16.6" "15.3" "17.2" "16.2" "17.4" "14.3" "13.2" "32.0" "" "" "" "" "" "" "" "" "" "" "8.9" "6.0" "9.2" "7.2" "8.0" "8.3" "8.1" "6.4" "7.2" "32.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3771039295331557619" "False" "High" "IsMasterProtein" "P12694" "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHA PE=1 SV=2" "0.002" "False" "3.317" "2" "1" "1" "1" "445" "50.4" "8.27" "1.76" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00676" "593" "ENSG00000248098" "BCKDHA" "B4DP47; E7EW46; hsa:593; P12694; Q16034; Q16472" "Lipid metabolism pathway" "Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism" "3" "0" "1.043" "1.066" "1.450" "0.913" "0.867" "0.799" "1.164" "1.322" "1.259" "30.2" "31.5" "32.2" "43.8" "27.6" "26.2" "24.1" "35.1" "39.9" "38.0" "" "" "" "" "" "" "" "" "" "" "18.1" "16.4" "17.8" "20.5" "12.8" "13.4" "11.2" "15.8" "21.7" "38.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2555590194794136668" "False" "High" "IsMasterProtein" "Q9C073" "Protein FAM117A OS=Homo sapiens OX=9606 GN=FAM117A PE=1 SV=1" "0.002" "False" "3.311" "2" "1" "1" "1" "453" "48.3" "8.31" "3.07" "1" "" "" "" "Pf15388" "81558" "ENSG00000121104" "FAM117A" "B7Z7Q3; hsa:81558; Q9C073" "" "" "0" "0" "1.022" "1.041" "1.003" "1.292" "1.007" "1.204" "1.013" "1.122" "0.996" "52.7" "53.9" "54.8" "52.8" "68.1" "53.1" "63.4" "53.4" "59.1" "52.5" "" "" "" "" "" "" "" "" "" "" "31.5" "28.0" "30.4" "24.8" "31.6" "27.2" "29.5" "24.0" "32.1" "52.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7154338873387211180" "False" "High" "IsMasterProtein" "Q8TDQ7" "Glucosamine-6-phosphate isomerase 2 OS=Homo sapiens OX=9606 GN=GNPDA2 PE=1 SV=1" "0.002" "False" "3.303" "3" "1" "1" "1" "276" "31.1" "6.95" "3.42" "1" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01182" "132789" "ENSG00000163281" "GNPDA2" "B4DJF3; hsa:132789; Q2VYF1; Q59EA7; Q8NCZ8; Q8TDQ7; Q96BJ4; Q96NC6" "" "Glycolysis" "1" "0" "1.064" "1.060" "1.134" "0.865" "1.163" "0.946" "1.221" "1.075" "0.751" "246.7" "262.6" "261.5" "279.8" "213.2" "286.8" "233.2" "301.1" "265.1" "185.2" "" "" "" "" "" "" "" "" "" "" "147.6" "136.4" "144.8" "131.4" "98.8" "146.8" "108.5" "135.2" "143.8" "185.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6249152470973198342" "False" "High" "IsMasterProtein" "Q9NYZ3" "G2 and S phase-expressed protein 1 OS=Homo sapiens OX=9606 GN=GTSE1 PE=1 SV=4" "0.002" "False" "3.300" "4" "2" "2" "2" "739" "78.5" "9.23" "0.00" "2" "cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf15259" "51512" "ENSG00000075218" "GTSE1" "B0QYM3; hsa:51512; Q20WK2; Q53GX5; Q5R3I6; Q6DHX4; Q9BRE0; Q9NYZ3; Q9UGZ9; Q9Y557" "" "G2/M Checkpoints; The role of GTSE1 in G2/M progression after G2 checkpoint" "2" "0" "1.286" "1.363" "1.464" "1.425" "1.221" "1.339" "1.522" "1.386" "0.920" "64.6" "83.1" "88.1" "94.6" "92.1" "78.9" "86.6" "98.4" "89.6" "59.4" "" "" "" "" "" "" "" "" "" "" "38.7" "43.2" "48.8" "44.4" "42.7" "40.4" "40.2" "44.2" "48.6" "59.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7548254055495868617" "False" "High" "IsMasterProtein" "Q9BZD4" "Kinetochore protein Nuf2 OS=Homo sapiens OX=9606 GN=NUF2 PE=1 SV=2" "0.002" "False" "3.296" "2" "1" "1" "1" "464" "54.3" "8.27" "2.81" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03800" "83540" "ENSG00000143228" "NUF2" "hsa:83540; Q8WU69; Q96HJ4; Q96Q78; Q9BZD4" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.999" "0.730" "0.991" "0.790" "0.841" "0.637" "0.010" "0.785" "9.288" "33.8" "33.7" "24.7" "33.5" "26.7" "28.4" "21.5" "0.0" "26.5" "313.8" "" "" "" "" "" "" "" "" "" "" "20.2" "17.5" "13.7" "15.7" "12.4" "14.5" "10.0" "0.0" "14.4" "313.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "Not Found" "High" "High" "1" "" "7438164124212550785" "False" "High" "IsMasterProtein" "Q96EV8" "Dysbindin OS=Homo sapiens OX=9606 GN=DTNBP1 PE=1 SV=1" "0.002" "False" "3.291" "3" "1" "1" "1" "351" "39.5" "4.67" "2.07" "1" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04440" "84062" "ENSG00000047579" "DTNBP1" "A8K3V3; hsa:84062; Q5THY3; Q5THY4; Q96EV8; Q96NV2; Q9H0U2; Q9H3J5" "Alstrom syndrome" "Golgi Associated Vesicle Biogenesis" "2" "0" "1.037" "1.135" "1.234" "0.935" "1.197" "1.177" "1.101" "0.887" "1.666" "47.6" "49.4" "54.1" "58.8" "44.5" "57.0" "56.1" "52.4" "42.3" "79.3" "" "" "" "" "" "" "" "" "" "" "28.5" "25.7" "29.9" "27.6" "20.6" "29.2" "26.1" "23.5" "22.9" "79.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6366050407919946154" "False" "High" "IsMasterProtein" "Q96II8" "DISP complex protein LRCH3 OS=Homo sapiens OX=9606 GN=LRCH3 PE=1 SV=2" "0.002" "False" "3.281" "2" "1" "1" "1" "777" "86.0" "6.71" "2.85" "1" "cell organization and biogenesis" "cytosol;other cell component" "" "Pf00307, Pf13855" "84859" "ENSG00000186001" "LRCH3" "B4E0T7; hsa:84859; Q96FP9; Q96II8; Q9NT52" "" "" "0" "0" "0.917" "0.908" "1.339" "1.299" "0.625" "0.910" "0.923" "1.148" "3.354" "16.4" "15.0" "14.9" "22.0" "21.3" "10.3" "14.9" "15.1" "18.8" "55.0" "" "" "" "" "" "" "" "" "" "" "9.8" "7.8" "8.2" "10.3" "9.9" "5.2" "6.9" "6.8" "10.2" "55.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5632561991288096733" "False" "High" "IsMasterProtein" "Q9H9Y6" "DNA-directed RNA polymerase I subunit RPA2 OS=Homo sapiens OX=9606 GN=POLR1B PE=1 SV=2" "0.002" "False" "3.275" "1" "1" "1" "1" "1135" "128.1" "7.83" "2.97" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf06883" "84172" "ENSG00000125630" "POLR1B" "B7Z6Y7; B7Z823; F5GZX4; F8W898; hsa:84172; Q2TAM4; Q585T5; Q6ZRR2; Q9H9D3; Q9H9Y6" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "8" "0" "1.025" "0.857" "0.988" "1.226" "1.084" "0.904" "0.626" "1.026" "4.055" "44.8" "46.0" "38.5" "44.3" "55.0" "48.6" "40.5" "28.1" "46.0" "181.9" "" "" "" "" "" "" "" "" "" "" "26.8" "23.9" "21.3" "20.8" "25.5" "24.9" "18.9" "12.6" "25.0" "181.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824788000835968644" "False" "High" "IsMasterProtein" "O15182" "Centrin-3 OS=Homo sapiens OX=9606 GN=CETN3 PE=1 SV=2" "0.002" "False" "3.274" "7" "1" "1" "1" "167" "19.5" "4.74" "2.42" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf13499" "1070" "ENSG00000153140" "CETN3" "hsa:1070; O15182; Q53YD2; Q9BS23" "Breast cancer pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1822975009015350041" "False" "High" "IsMasterProtein" "P60228" "Eukaryotic translation initiation factor 3 subunit E OS=Homo sapiens OX=9606 GN=EIF3E PE=1 SV=1" "0.002" "False" "3.268" "5" "2" "2" "2" "445" "52.2" "6.04" "1.60" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01399, Pf09440, Pf21357" "3646" "ENSG00000104408" "EIF3E" "hsa:3646; O43902; P60228; Q64058; Q64059; Q64252; Q6FG33; Q8WVK4" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5626279923656509616" "False" "High" "IsMasterProtein" "P25325" "3-mercaptopyruvate sulfurtransferase OS=Homo sapiens OX=9606 GN=MPST PE=1 SV=3" "0.002" "False" "3.268" "4" "1" "1" "1" "297" "33.2" "6.60" "2.93" "1" "other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00581" "4357" "ENSG00000128309" "MPST" "A8MZ34; B3KP52; hsa:4357; J3KPV7; O75750; P25325; Q6FHN9" "Trans-sulfuration pathway; Amino acid metabolism" "Degradation of cysteine and homocysteine" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6639760008816947129" "False" "High" "IsMasterProtein" "Q6ZUM4" "Rho GTPase-activating protein 27 OS=Homo sapiens OX=9606 GN=ARHGAP27 PE=1 SV=3" "0.002" "False" "3.261" "3" "2" "2" "2" "889" "98.3" "5.59" "3.03" "2" "transport;signal transduction;other biological processes" "other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00397, Pf00620" "201176" "ENSG00000159314; ENSG00000276836; ENSG00000276907" "ARHGAP27" "A4FU35; A8K3N5; C9JTF3; hsa:201176; Q494U0; Q6NWZ8; Q6ZUM4; Q8WY58" "" "CDC42 GTPase cycle; RAC1 GTPase cycle" "2" "0" "0.947" "0.622" "1.017" "1.212" "0.912" "1.017" "1.179" "1.020" "1.213" "38.4" "36.3" "23.9" "39.0" "46.5" "35.0" "39.0" "45.2" "39.1" "46.5" "" "" "" "" "" "" "" "" "" "" "23.0" "18.9" "13.2" "18.3" "21.6" "17.9" "18.1" "20.3" "21.2" "46.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4408499482478688157" "False" "High" "IsMasterProtein" "Q9Y4X4" "Krueppel-like factor 12 OS=Homo sapiens OX=9606 GN=KLF12 PE=1 SV=2" "0.002" "False" "3.251" "3" "1" "1" "1" "402" "44.2" "9.70" "2.92" "1" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "11278" "ENSG00000118922" "KLF12" "A8K5T2; hsa:11278; L0R3J4; Q5VZM7; Q9UHZ0; Q9Y4X4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3376743551660886452" "False" "High" "IsMasterProtein" "Q8N5L8" "Ribonuclease P protein subunit p25-like protein OS=Homo sapiens OX=9606 GN=RPP25L PE=1 SV=1" "0.002" "False" "3.242" "6" "1" "1" "1" "163" "17.6" "10.30" "2.67" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf01918" "138716" "ENSG00000164967" "RPP25L" "D3DRM5; hsa:138716; Q8N5L8" "" "" "0" "0" "0.723" "0.811" "1.030" "0.931" "0.943" "0.875" "0.860" "1.000" "0.918" "50.3" "36.4" "40.8" "51.8" "46.9" "47.4" "44.0" "43.3" "50.3" "46.2" "" "" "" "" "" "" "" "" "" "" "30.1" "18.9" "22.6" "24.3" "21.7" "24.3" "20.5" "19.4" "27.3" "46.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-386801928701098306" "False" "High" "IsMasterProtein" "Q6ULP2" "Aftiphilin OS=Homo sapiens OX=9606 GN=AFTPH PE=1 SV=3" "0.002" "False" "3.237" "1" "1" "1" "1" "936" "102.1" "4.54" "2.84" "1" "transport" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf15045" "54812" "ENSG00000119844" "AFTPH" "D6W5E9; hsa:54812; Q6ULP2; Q6ZM66; Q86VW3; Q8TCF3; Q9H7E3; Q9HAB9; Q9NXS4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5978569898189539548" "False" "High" "IsMasterProtein" "O75694" "Nuclear pore complex protein Nup155 OS=Homo sapiens OX=9606 GN=NUP155 PE=1 SV=1" "0.002" "False" "3.235" "1" "1" "1" "1" "1391" "155.1" "6.16" "0.00" "1" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf08801" "9631" "ENSG00000113569" "NUP155" "hsa:9631; O75694; Q9UBE9; Q9UFL5" "" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "1.024" "0.791" "1.353" "1.245" "1.008" "1.309" "1.285" "0.959" "0.938" "26.2" "26.8" "20.7" "35.4" "32.6" "26.4" "34.3" "33.7" "25.1" "24.6" "" "" "" "" "" "" "" "" "" "" "15.7" "13.9" "11.5" "16.6" "15.1" "13.5" "15.9" "15.1" "13.6" "24.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3366730786778732406" "False" "High" "IsMasterProtein" "Q9UKB3" "DnaJ homolog subfamily C member 12 OS=Homo sapiens OX=9606 GN=DNAJC12 PE=1 SV=1" "0.002" "False" "3.235" "5" "1" "1" "1" "198" "23.4" "5.71" "2.44" "1" "" "other cell component" "" "Pf00226" "56521" "ENSG00000108176" "DNAJC12" "hsa:56521; Q5JVQ1; Q9UKB2; Q9UKB3" "" "" "0" "0" "0.849" "0.924" "0.789" "1.187" "1.167" "0.742" "0.790" "1.109" "0.793" "26.7" "22.7" "24.7" "21.1" "31.7" "31.2" "19.8" "21.1" "29.6" "21.2" "" "" "" "" "" "" "" "" "" "" "16.0" "11.8" "13.7" "9.9" "14.7" "16.0" "9.2" "9.5" "16.1" "21.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2559725886688787495" "False" "High" "IsMasterProtein" "Q8WYP3" "Ras and Rab interactor 2 OS=Homo sapiens OX=9606 GN=RIN2 PE=1 SV=1" "0.002" "False" "3.232" "1" "1" "4" "1" "895" "100.1" "6.58" "6.55" "1" "transport;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00788, Pf02204" "54453" "ENSG00000132669" "RIN2" "hsa:54453; Q00425; Q5TFT8; Q8WYP3; Q9BQL3; Q9H071" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "0.958" "0.990" "0.931" "0.800" "0.802" "0.858" "0.914" "0.908" "0.561" "587.9" "563.4" "581.9" "547.1" "470.1" "471.5" "504.3" "537.6" "533.6" "330.0" "" "" "" "" "" "" "" "" "" "" "351.8" "292.8" "322.2" "256.9" "217.9" "241.4" "234.5" "241.4" "289.5" "330.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6704752873658697689" "False" "High" "IsMasterProtein" "P37268" "Squalene synthase OS=Homo sapiens OX=9606 GN=FDFT1 PE=1 SV=1" "0.002" "False" "3.229" "4" "2" "2" "2" "417" "48.1" "6.54" "4.30" "2" "other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00494" "2222" "ENSG00000079459; ENSG00000284967" "FDFT1" "B3KQ95; B4DJE5; B4DT56; B7Z1J3; hsa:2222; P37268; Q96GT0" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Statin inhibition of cholesterol production; Ferroptosis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism; 8p23.1 copy number variation syndrome" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1699378345202944964" "False" "High" "IsMasterProtein" "Q96MX6" "Dynein axonemal assembly factor 10 OS=Homo sapiens OX=9606 GN=DNAAF10 PE=1 SV=1" "0.002" "False" "3.224" "2" "1" "1" "1" "357" "39.7" "8.09" "2.19" "1" "cell organization and biogenesis;other biological processes" "other cell component" "other molecular function" "Pf00400" "116143" "ENSG00000243667" "DNAAF10" "hsa:116143; Q96CR6; Q96MX6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7506213950327089282" "False" "High" "IsMasterProtein" "Q8IUF8" "Ribosomal oxygenase 2 OS=Homo sapiens OX=9606 GN=RIOX2 PE=1 SV=1" "0.002" "False" "3.224" "2" "1" "1" "1" "465" "52.8" "6.70" "2.97" "1" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08007, Pf20514" "84864" "ENSG00000170854" "RIOX2" "D3DN35; Q6AHW4; Q6SKS0; Q8IU69; Q8IUF6; Q8IUF7; Q8IUF8; Q96C17; Q96KB0" "" "Protein hydroxylation; HDMs demethylate histones" "2" "0" "1.437" "0.942" "1.071" "1.030" "0.921" "1.120" "0.980" "0.839" "2.374" "31.5" "45.3" "29.7" "33.7" "32.5" "29.0" "35.3" "30.9" "26.4" "74.8" "" "" "" "" "" "" "" "" "" "" "18.8" "23.5" "16.4" "15.8" "15.0" "14.9" "16.4" "13.9" "14.3" "74.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5030873736405490960" "False" "High" "IsMasterProtein" "Q92686" "Neurogranin OS=Homo sapiens OX=9606 GN=NRGN PE=1 SV=1" "0.002" "False" "3.221" "18" "1" "2" "1" "78" "7.6" "7.87" "4.98" "1" "developmental processes;signal transduction" "cytosol" "other molecular function" "Pf00612" "4900" "ENSG00000154146" "NRGN" "hsa:4900; Q92686" "" "Long-term potentiation" "1" "0" "0.921" "0.932" "1.127" "1.344" "1.064" "1.130" "1.022" "0.968" "0.581" "29.8" "27.4" "27.8" "33.6" "40.0" "31.7" "33.7" "30.4" "28.9" "17.3" "" "" "" "" "" "" "" "" "" "" "17.8" "14.3" "15.4" "15.8" "18.6" "16.2" "15.7" "13.7" "15.7" "17.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2106414634070186016" "False" "High" "IsMasterProtein" "Q8WVM8" "Sec1 family domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SCFD1 PE=1 SV=4" "0.002" "False" "3.220" "2" "2" "2" "2" "642" "72.3" "6.27" "3.59" "2" "stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00995" "23256" "ENSG00000092108" "SCFD1" "A8K2Z5; B7Z4U7; B7Z594; hsa:23256; O60754; O94990; Q7Z529; Q8WVM8; Q9BZI3; Q9UNL3; Q9Y6A8" "" "RHOA GTPase cycle; COPII-mediated vesicle transport" "2" "0" "0.631" "0.460" "1.016" "0.863" "0.964" "0.010" "0.010" "1.082" "6.940" "10.5" "6.6" "4.8" "10.7" "9.1" "10.1" "0.0" "0.0" "11.4" "72.9" "" "" "" "" "" "" "" "" "" "" "6.3" "3.4" "2.7" "5.0" "4.2" "5.2" "0.0" "0.0" "6.2" "72.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3527140061799616806" "False" "High" "IsMasterProtein" "Q9BW19" "Kinesin-like protein KIFC1 OS=Homo sapiens OX=9606 GN=KIFC1 PE=1 SV=2" "0.002" "False" "3.219" "1" "1" "1" "1" "673" "73.7" "8.98" "2.44" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cytoplasmic organelle" "cytoskeletal activity;other molecular function" "Pf00225" "3833" "ENSG00000204197; ENSG00000233450; ENSG00000237649" "KIFC1" "hsa:3833; O60887; Q14834; Q4KMP0; Q5SU09; Q6GMS7; Q6P4A5; Q9BW19; Q9UQP7" "" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "2" "0" "1.147" "1.490" "0.743" "1.543" "1.631" "1.196" "1.139" "1.068" "2.983" "29.1" "33.4" "43.4" "21.6" "44.9" "47.5" "34.8" "33.2" "31.1" "86.9" "" "" "" "" "" "" "" "" "" "" "17.4" "17.4" "24.0" "10.2" "20.8" "24.3" "16.2" "14.9" "16.9" "86.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5438538710980627953" "False" "High" "IsMasterProtein" "Q9H2C0" "Gigaxonin OS=Homo sapiens OX=9606 GN=GAN PE=1 SV=1" "0.002" "False" "3.215" "3" "2" "2" "2" "597" "67.6" "5.85" "2.53" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "" "Pf00651, Pf01344, Pf07707" "8139" "ENSG00000261609" "GAN" "hsa:8139; Q9H2C0" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1086525266732812690" "False" "High" "IsMasterProtein" "Q9Y5P4" "Ceramide transfer protein OS=Homo sapiens OX=9606 GN=CERT1 PE=1 SV=1" "0.002" "False" "3.209" "2" "1" "1" "1" "624" "70.8" "5.48" "2.50" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus" "transporter activity;kinase activity;other molecular function" "Pf00169, Pf01852" "10087" "ENSG00000113163" "CERT1" "A8K7S2; B3KUB7; hsa:10087; Q53YV1; Q53YV2; Q96Q85; Q96Q88; Q9H2S7; Q9H2S8; Q9Y5P4" "Sphingolipid pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-123895126992999128" "False" "High" "IsMasterProtein" "Q96BR5" "Cytochrome c oxidase assembly factor 7 OS=Homo sapiens OX=9606 GN=COA7 PE=1 SV=2" "0.002" "False" "3.209" "4" "1" "1" "1" "231" "25.7" "6.02" "2.88" "1" "" "mitochondrion;nucleus" "" "Pf08238" "65260" "ENSG00000162377" "COA7" "hsa:65260; Q0P6I7; Q96BR5; Q9H9Z9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3643630707960143102" "False" "High" "IsMasterProtein" "Q4KWH8" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 OS=Homo sapiens OX=9606 GN=PLCH1 PE=1 SV=1" "0.002" "False" "3.208" "0" "1" "5" "1" "1693" "189.1" "7.74" "13.59" "1" "other metabolic processes;transport;signal transduction" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00168, Pf00387, Pf00388, Pf09279, Pf16457" "23007" "ENSG00000114805" "PLCH1" "hsa:23007; Q29RV9; Q4KWH8; Q4KWH9; Q68CN0; Q86XK4; Q9H9U2; Q9UPT3" "Mesodermal commitment pathway; GPR40 pathway" "Synthesis of IP3 and IP4 in the cytosol" "3" "0" "0.831" "0.820" "0.804" "0.865" "0.960" "0.736" "0.918" "0.793" "0.865" "433.2" "360.1" "355.4" "348.4" "374.7" "415.7" "319.0" "397.7" "343.6" "374.9" "" "" "" "" "" "" "" "" "" "" "259.2" "187.1" "196.8" "163.6" "173.7" "212.8" "148.3" "178.6" "186.4" "374.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8595092831186639682" "False" "High" "IsMasterProtein" "Q99961" "Endophilin-A2 OS=Homo sapiens OX=9606 GN=SH3GL1 PE=1 SV=1" "0.002" "False" "3.204" "2" "1" "1" "1" "368" "41.5" "5.43" "2.85" "1" "cell organization and biogenesis;transport;developmental processes;signal transduction" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf03114" "6455" "ENSG00000141985" "SH3GL1" "B4DRA1; E7EVZ4; hsa:6455; M0QZV5; Q99668; Q99961" "Fragile X syndrome" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4578961420069997890" "False" "High" "IsMasterProtein" "P31930" "Cytochrome b-c1 complex subunit 1, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC1 PE=1 SV=3" "0.002" "False" "3.203" "2" "1" "1" "1" "480" "52.6" "6.37" "2.34" "1" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00675, Pf05193" "7384" "ENSG00000010256" "UQCRC1" "B2R7R8; hsa:7384; P31930; Q96DD2" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "Respiratory electron transport" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3557682221437211922" "False" "High" "IsMasterProtein" "Q9Y6Q9" "Nuclear receptor coactivator 3 OS=Homo sapiens OX=9606 GN=NCOA3 PE=1 SV=1" "0.002" "False" "3.201" "1" "1" "1" "1" "1424" "155.2" "7.47" "0.00" "1" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00989, Pf07469, Pf08815, Pf08832, Pf14598, Pf16279, Pf16665" "8202" "ENSG00000124151" "NCOA3" "A4LAZ5; hsa:8202; Q0VF45; Q5JYD9; Q5JYE0; Q9BR49; Q9UPC9; Q9UPG4; Q9UPG7; Q9Y6Q9" "Androgen receptor signaling pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Breast cancer pathway; EGF/EGFR signaling pathway; Rubinstein-Taybi syndrome 1" "Estrogen-dependent gene expression; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; MAPK6/MAPK4 signaling; Activation of anterior HOX genes in hindbrain development during early embryogenesis" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7656229856008546485" "False" "High" "IsMasterProtein" "O95453" "Poly(A)-specific ribonuclease PARN OS=Homo sapiens OX=9606 GN=PARN PE=1 SV=1" "0.002" "False" "3.196" "2" "1" "1" "1" "639" "73.4" "6.20" "2.74" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04857, Pf08675" "5073" "ENSG00000140694; ENSG00000274829" "PARN" "B2RCB3; B4DDG8; B4DSB0; B4DWR4; B4E1H6; hsa:5073; O95453" "Lung fibrosis" "Deadenylation of mRNA; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4717651617297181896" "False" "High" "IsMasterProtein" "Q9UIC8" "Leucine carboxyl methyltransferase 1 OS=Homo sapiens OX=9606 GN=LCMT1 PE=1 SV=2" "0.002" "False" "3.193" "3" "1" "2" "1" "334" "38.4" "6.04" "3.27" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04072" "51451" "ENSG00000205629" "LCMT1" "A6NL89; A8K770; hsa:51451; Q53FC5; Q96CI5; Q9H6I9; Q9NTG4; Q9UIC8; Q9Y378" "" "Cyclin A/B1/B2 associated events during G2/M transition" "1" "0" "0.962" "0.953" "1.152" "1.087" "0.987" "1.193" "1.054" "1.130" "1.550" "99.7" "95.9" "95.0" "114.8" "108.3" "98.4" "118.9" "105.1" "112.6" "154.5" "" "" "" "" "" "" "" "" "" "" "59.7" "49.8" "52.6" "53.9" "50.2" "50.4" "55.3" "47.2" "61.1" "154.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6180191668945880169" "False" "High" "IsMasterProtein" "Q9H269" "Vacuolar protein sorting-associated protein 16 homolog OS=Homo sapiens OX=9606 GN=VPS16 PE=1 SV=2" "0.002" "False" "3.185" "1" "1" "1" "1" "839" "94.6" "6.77" "2.44" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf04840, Pf04841" "64601" "ENSG00000215305" "VPS16" "hsa:64601; Q5JUB1; Q8WU31; Q96EE7; Q96N92; Q9H1Q4; Q9H1Q5; Q9H269" "Ebola virus infection in host; Network map of SARS-CoV-2 signaling pathway" "SARS-CoV-2 modulates autophagy" "3" "0" "0.677" "0.926" "0.918" "0.823" "0.818" "1.018" "0.841" "0.818" "4.949" "18.3" "12.4" "17.0" "16.8" "15.1" "15.0" "18.7" "15.4" "15.0" "90.6" "" "" "" "" "" "" "" "" "" "" "11.0" "6.4" "9.4" "7.9" "7.0" "7.7" "8.7" "6.9" "8.1" "90.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1601999827614054718" "False" "High" "IsMasterProtein" "O95067" "G2/mitotic-specific cyclin-B2 OS=Homo sapiens OX=9606 GN=CCNB2 PE=1 SV=1" "0.002" "False" "3.183" "2" "1" "1" "1" "398" "45.3" "8.90" "3.31" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00134, Pf02984" "9133" "ENSG00000157456" "CCNB2" "B3KM93; hsa:9133; O95067; Q6FI99" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; IL-18 signaling pathway; DNA damage response" "Resolution of Sister Chromatid Cohesion; Initiation of Nuclear Envelope (NE) Reformation; The role of GTSE1 in G2/M progression after G2 checkpoint; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint" "17" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5939280561053710644" "False" "High" "IsMasterProtein" "Q9P0T4" "Zinc finger protein 581 OS=Homo sapiens OX=9606 GN=ZNF581 PE=1 SV=1" "0.002" "False" "3.183" "5" "1" "1" "1" "197" "22.0" "8.82" "2.60" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13894" "51545" "ENSG00000171425" "ZNF581" "B2RDM6; hsa:51545; Q9P0T4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7573385717766537595" "False" "High" "IsMasterProtein" "Q9GZT9" "Egl nine homolog 1 OS=Homo sapiens OX=9606 GN=EGLN1 PE=1 SV=1" "0.002" "False" "3.178" "3" "1" "1" "1" "426" "46.0" "8.53" "2.22" "1" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01753, Pf13640" "54583" "ENSG00000135766" "EGLN1" "hsa:54583; Q8N3M8; Q9BZS8; Q9BZT0; Q9GZT9" "Photodynamic therapy-induced HIF-1 survival signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Type 2 papillary renal cell carcinoma; Markers of kidney cell lineage" "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha" "5" "0" "1.103" "1.177" "0.793" "1.015" "1.039" "1.214" "0.818" "0.956" "1.819" "26.5" "29.2" "31.1" "21.0" "26.8" "27.5" "32.1" "21.6" "25.3" "48.1" "" "" "" "" "" "" "" "" "" "" "15.8" "15.2" "17.2" "9.8" "12.4" "14.1" "14.9" "9.7" "13.7" "48.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "472644769200762840" "False" "High" "IsMasterProtein" "Q9UJK0" "18S rRNA aminocarboxypropyltransferase OS=Homo sapiens OX=9606 GN=TSR3 PE=1 SV=1" "0.002" "False" "3.178" "5" "1" "1" "1" "312" "33.6" "6.87" "2.08" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol" "other molecular function" "Pf04034, Pf04068" "115939" "ENSG00000007520" "TSR3" "hsa:115939; Q6PJT8; Q9UJK0" "" "rRNA modification in the nucleus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "High" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "High" "High" "1" "" "-7097092162087690863" "False" "High" "IsMasterProtein" "O43683" "Mitotic checkpoint serine/threonine-protein kinase BUB1 OS=Homo sapiens OX=9606 GN=BUB1 PE=1 SV=1" "0.002" "False" "3.175" "1" "1" "1" "1" "1085" "122.3" "6.47" "1.89" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf08311" "699" "ENSG00000169679" "BUB1" "E9PC26; F5GXI5; hsa:699; O43430; O43643; O43683; O60626; Q53QE4" "Cell cycle; ATM signaling in development and disease ; Regulation of sister chromatid separation at the metaphase-anaphase transition" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "9" "0" "0.538" "0.452" "0.457" "0.833" "0.442" "0.611" "0.668" "0.672" "3.519" "17.5" "9.4" "7.9" "8.0" "14.6" "7.7" "10.7" "11.7" "11.8" "61.6" "" "" "" "" "" "" "" "" "" "" "10.5" "4.9" "4.4" "3.8" "6.8" "4.0" "5.0" "5.3" "6.4" "61.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3536014580655726636" "False" "High" "IsMasterProtein" "P98170" "E3 ubiquitin-protein ligase XIAP OS=Homo sapiens OX=9606 GN=XIAP PE=1 SV=2" "0.002" "False" "3.172" "2" "1" "1" "1" "497" "56.6" "6.65" "3.42" "1" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00653, Pf13920, Pf21290" "331" "ENSG00000101966" "XIAP" "D3DTF2; hsa:331; P98170; Q9NQ14" "Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis modulation and signaling; Apoptosis; Focal adhesion; Copper homeostasis; NO/cGMP/PKG mediated neuroprotection; Complement system in neuronal development and plasticity" "Regulation of PTEN stability and activity; Deactivation of the beta-catenin transactivating complex; Regulation of necroptotic cell death; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling; Regulation of PTEN localization" "20" "0" "1.221" "1.188" "1.142" "1.460" "1.475" "1.150" "1.159" "1.046" "1.741" "66.6" "81.3" "79.1" "76.0" "97.2" "98.2" "76.6" "77.2" "69.6" "115.9" "" "" "" "" "" "" "" "" "" "" "39.8" "42.3" "43.8" "35.7" "45.1" "50.3" "35.6" "34.6" "37.8" "115.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2026118880241708351" "False" "High" "IsMasterProtein" "A5PLN9" "Trafficking protein particle complex subunit 13 OS=Homo sapiens OX=9606 GN=TRAPPC13 PE=1 SV=2" "0.002" "False" "3.167" "2" "1" "1" "1" "417" "46.5" "5.60" "2.06" "1" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf06159" "80006" "ENSG00000113597" "TRAPPC13" "A5PLN9; hsa:80006; Q17RZ9; Q49A23; Q4JHG0; Q6MZG4; Q8TCM2; Q9H8I3" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "0.750" "1.839" "1.384" "0.609" "2.052" "1.756" "0.910" "1.651" "7.049" "8.3" "6.3" "15.3" "11.5" "5.1" "17.1" "14.7" "7.6" "13.8" "58.8" "" "" "" "" "" "" "" "" "" "" "5.0" "3.3" "8.5" "5.4" "2.4" "8.8" "6.8" "3.4" "7.5" "58.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2583602978446666213" "False" "High" "IsMasterProtein" "O15514" "DNA-directed RNA polymerase II subunit RPB4 OS=Homo sapiens OX=9606 GN=POLR2D PE=1 SV=1" "0.002" "False" "3.166" "11" "2" "3" "2" "142" "16.3" "4.79" "6.94" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf03874" "5433" "ENSG00000144231" "POLR2D" "hsa:5433; O15514; Q52LT4" "Pyrimidine metabolism" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "42" "0" "0.936" "0.926" "0.967" "1.048" "0.886" "0.974" "0.846" "0.930" "0.585" "201.3" "188.3" "186.3" "194.7" "210.9" "178.4" "196.1" "170.3" "187.1" "117.8" "" "" "" "" "" "" "" "" "" "" "120.5" "97.9" "103.2" "91.4" "97.8" "91.3" "91.2" "76.5" "101.5" "117.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6553224162090552303" "False" "High" "IsMasterProtein" "Q9Y3A3" "MOB-like protein phocein OS=Homo sapiens OX=9606 GN=MOB4 PE=1 SV=1" "0.002" "False" "3.165" "4" "1" "1" "1" "225" "26.0" "5.78" "2.91" "1" "" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf03637" "25843" "ENSG00000115540" "MOB4" "B4DML0; hsa:25843; Q53SE0; Q7Z4Y6; Q9H2P3; Q9H5J1; Q9Y3A3; Q9Y4T8" "" "" "0" "0" "1.095" "0.892" "1.119" "1.090" "1.030" "0.901" "0.969" "1.026" "0.700" "162.3" "177.7" "144.9" "181.7" "176.9" "167.3" "146.3" "157.4" "166.6" "113.6" "" "" "" "" "" "" "" "" "" "" "97.2" "92.3" "80.2" "85.3" "82.0" "85.6" "68.0" "70.7" "90.4" "113.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2429819292905121696" "False" "High" "IsMasterProtein" "P57077" "MAP3K7 C-terminal-like protein OS=Homo sapiens OX=9606 GN=MAP3K7CL PE=1 SV=2" "0.002" "False" "3.159" "7" "1" "1" "1" "142" "16.4" "4.89" "2.85" "1" "" "" "" "" "56911" "ENSG00000156265; ENSG00000291525" "MAP3K7CL" "D3DSE0; hsa:56911; P57077; Q8TCL9" "" "" "0" "0" "0.930" "0.987" "0.933" "1.116" "0.823" "1.078" "0.969" "0.912" "0.560" "52.0" "48.3" "51.3" "48.5" "58.0" "42.7" "56.0" "50.4" "47.4" "29.1" "" "" "" "" "" "" "" "" "" "" "31.1" "25.1" "28.4" "22.8" "26.9" "21.9" "26.0" "22.6" "25.7" "29.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2870938991305949224" "False" "High" "IsMasterProtein" "P15848" "Arylsulfatase B OS=Homo sapiens OX=9606 GN=ARSB PE=1 SV=1" "0.002" "False" "3.158" "2" "1" "1" "1" "533" "59.6" "8.21" "2.98" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00884" "411" "ENSG00000113273" "ARSB" "B2RC20; hsa:411; P15848; Q8N322; Q9UDI9" "Glycosaminoglycan degradation" "Neutrophil degranulation; CS/DS degradation; Glycosphingolipid catabolism; The activation of arylsulfatases; MPS VI - Maroteaux-Lamy syndrome" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4146618986531713622" "False" "High" "IsMasterProtein" "P46782" "Small ribosomal subunit protein uS7 OS=Homo sapiens OX=9606 GN=RPS5 PE=1 SV=4" "0.002" "False" "3.156" "4" "1" "2" "1" "204" "22.9" "9.72" "6.09" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00177" "6193" "ENSG00000083845" "RPS5" "B2R4T2; hsa:6193; P46782; Q96BN0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.976" "0.826" "0.913" "1.039" "0.945" "0.860" "0.811" "1.027" "1.910" "78.4" "76.5" "64.7" "71.6" "81.4" "74.1" "67.4" "63.6" "80.5" "149.6" "" "" "" "" "" "" "" "" "" "" "46.9" "39.7" "35.8" "33.6" "37.8" "37.9" "31.3" "28.5" "43.6" "149.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5097285546309815512" "False" "High" "IsMasterProtein" "Q8NEB9" "Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Homo sapiens OX=9606 GN=PIK3C3 PE=1 SV=1" "0.002" "False" "3.152" "1" "1" "1" "1" "887" "101.5" "6.81" "2.12" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792" "5289" "ENSG00000078142" "PIK3C3" "hsa:5289; Q15134; Q8NEB9" "AMP-activated protein kinase signaling; Alzheimer's disease and miRNA effects; Angiopoietin-like protein 8 regulatory pathway; Microglia pathogen phagocytosis pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Osteoblast differentiation and related diseases; Insulin signaling; Autophagy; Regulation of actin cytoskeleton; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP; DNA damage response (only ATM dependent)" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; PI3K Cascade; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; RHO GTPases Activate NADPH Oxidases; Toll Like Receptor 9 (TLR9) Cascade" "24" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-580971408817382446" "False" "High" "IsMasterProtein" "O75956" "Cyclin-dependent kinase 2-associated protein 2 OS=Homo sapiens OX=9606 GN=CDK2AP2 PE=1 SV=1" "0.002" "False" "3.150" "6" "1" "1" "1" "126" "13.1" "9.48" "3.43" "1" "other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf09806" "10263" "ENSG00000167797" "CDK2AP2" "hsa:10263; O75956" "" "" "0" "0" "1.055" "0.897" "0.834" "1.225" "1.103" "1.187" "1.020" "0.985" "0.574" "124.3" "131.2" "111.6" "103.8" "152.4" "137.2" "147.6" "126.8" "122.5" "71.3" "" "" "" "" "" "" "" "" "" "" "74.4" "68.2" "61.8" "48.7" "70.6" "70.2" "68.6" "56.9" "66.5" "71.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9085991407022296267" "False" "High" "IsMasterProtein" "P01920" "HLA class II histocompatibility antigen, DQ beta 1 chain OS=Homo sapiens OX=9606 GN=HLA-DQB1 PE=1 SV=2" "0.002" "False" "3.146" "3" "1" "2" "1" "261" "30.0" "7.25" "6.16" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00969, Pf07654" "3119" "ENSG00000225824; ENSG00000231286; ENSG00000233209" "HLA-DQB1" "A1KR27; A2RPH3; A4Q9R4; A4USG2; A4USG5; A6N8I7; A9YQA0; B0S7Y7; B1A0K6; B1GXI3; B3VLT3; B5BLN7; B7VU69; C0MQ34; C0MQ35; C8ZL52; C8ZLJ8; C8ZLJ9; C9DRQ3; hsa:3119; O19708; O19713; O19724; O62861; O78046; O78221; O78223; O98034; O98201; P01917; P01918; P01919; P01920; P03992; P05537; P79482; P79526; P79544; P79551; Q08GC8; Q09035; Q0E4V9; Q1M312; Q29731; Q29877; Q29884; Q29915; Q29966; Q2P9N3; Q2QK85; Q30061; Q30075; Q30076; Q30080; Q30081; Q30082; Q30083; Q30084; Q30089; Q30095; Q31633; Q38I47; Q45UE3; Q4QZB5; Q53I44; Q564J6; Q5G841; Q5ISH1; Q5ISH3; Q5W1E1; Q5Y7G8; Q643R4; Q6B9X1; Q70VH8; Q7YP69; Q8HWH0; Q8MH58; Q8SNB4; Q8SND1; Q8SP70; Q8WMA3; Q9BD17; Q9MYH2; Q9TPA9; Q9XRY6; Q9XRY7; Q9XRZ2" "Allograft rejection" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "8" "0" "0.975" "1.126" "0.945" "1.130" "1.054" "1.188" "0.975" "1.085" "0.601" "109.7" "106.9" "123.5" "103.6" "123.9" "115.6" "130.2" "106.9" "119.0" "65.9" "" "" "" "" "" "" "" "" "" "" "65.6" "55.5" "68.4" "48.6" "57.4" "59.2" "60.6" "48.0" "64.5" "65.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6335847497915133656" "False" "High" "IsMasterProtein" "Q9BTY7" "Protein HGH1 homolog OS=Homo sapiens OX=9606 GN=HGH1 PE=1 SV=1" "0.002" "False" "3.141" "3" "1" "1" "1" "390" "42.1" "4.81" "2.73" "1" "" "" "" "Pf04063, Pf04064" "51236" "ENSG00000235173" "HGH1" "hsa:51236; P0CB43; Q9BTY7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1035023352736906795" "False" "High" "IsMasterProtein" "O00399" "Dynactin subunit 6 OS=Homo sapiens OX=9606 GN=DCTN6 PE=1 SV=1" "0.002" "False" "3.139" "4" "1" "1" "1" "190" "20.7" "6.32" "2.64" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;other cell component" "other molecular function" "" "10671" "ENSG00000104671" "DCTN6" "B2RAC1; hsa:10671; O00399" "Vasopressin-regulated water reabsorption" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "407233124236787373" "False" "High" "IsMasterProtein" "Q96DB5" "Regulator of microtubule dynamics protein 1 OS=Homo sapiens OX=9606 GN=RMDN1 PE=1 SV=1" "0.002" "False" "3.134" "3" "1" "1" "1" "314" "35.8" "8.50" "2.78" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity" "Pf21033" "51115" "ENSG00000176623" "RMDN1" "A9UMZ8; B4DNF5; B4DZW6; B5MC61; C9JSC6; E7EVI2; hsa:51115; Q96DB5; Q9Y398" "" "" "0" "0" "1.026" "1.084" "1.051" "1.279" "1.073" "1.263" "1.080" "0.998" "2.045" "38.7" "39.7" "41.9" "40.6" "49.5" "41.5" "48.8" "41.8" "38.6" "79.1" "" "" "" "" "" "" "" "" "" "" "23.1" "20.6" "23.2" "19.1" "22.9" "21.2" "22.7" "18.7" "20.9" "79.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1558588285545917257" "False" "High" "IsMasterProtein" "O75531" "Barrier-to-autointegration factor OS=Homo sapiens OX=9606 GN=BANF1 PE=1 SV=1" "0.002" "False" "3.122" "9" "1" "1" "1" "89" "10.1" "6.09" "2.64" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02961" "8815" "ENSG00000175334" "BANF1" "hsa:8815; O60558; O75531; Q6FGG7" "Envelope proteins and their potential roles in EDMD physiopathology; Familial partial lipodystrophy; Progeria-associated lipodystrophy" "Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation" "11" "0" "1.191" "1.295" "1.448" "1.580" "1.332" "1.121" "1.377" "1.679" "0.080" "54.7" "65.2" "70.8" "79.2" "86.4" "72.8" "61.3" "75.3" "91.8" "4.4" "" "" "" "" "" "" "" "" "" "" "32.7" "33.9" "39.2" "37.2" "40.1" "37.3" "28.5" "33.8" "49.8" "4.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4967906594537230573" "False" "High" "IsMasterProtein" "Q9NUG6" "p53 and DNA damage-regulated protein 1 OS=Homo sapiens OX=9606 GN=PDRG1 PE=1 SV=2" "0.002" "False" "3.120" "6" "1" "1" "1" "133" "15.5" "6.06" "3.14" "1" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "81572" "ENSG00000088356" "PDRG1" "B2R511; hsa:81572; Q96GP3; Q9BUW8; Q9NUG6" "" "" "0" "0" "1.050" "0.969" "1.090" "1.351" "1.088" "1.206" "1.069" "1.223" "1.870" "91.5" "96.1" "88.7" "99.8" "123.6" "99.6" "110.4" "97.8" "112.0" "171.2" "" "" "" "" "" "" "" "" "" "" "54.8" "49.9" "49.1" "46.8" "57.3" "51.0" "51.3" "43.9" "60.8" "171.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4477032751293866758" "False" "High" "IsMasterProtein" "Q96MF7" "E3 SUMO-protein ligase NSE2 OS=Homo sapiens OX=9606 GN=NSMCE2 PE=1 SV=2" "0.002" "False" "3.118" "4" "1" "1" "1" "247" "27.9" "7.74" "2.68" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11789" "286053" "ENSG00000156831" "NSMCE2" "hsa:286053; Q8N549; Q96MF7" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5243679290783972836" "False" "High" "IsMasterProtein" "Q5JPE7" "BOS complex subunit NOMO2 OS=Homo sapiens OX=9606 GN=NOMO2 PE=1 SV=1" "0.002" "False" "3.117" "1" "1" "1" "1" "1267" "139.4" "5.76" "2.30" "1" "cell organization and biogenesis" "other membranes;cytosol;ER/Golgi;other cell component" "translation activity;other molecular function" "Pf13620, Pf17802" "283820" "ENSG00000185164" "NOMO2" "hsa:283820; Q4G177; Q5JPE7" "" "" "0" "0" "1.366" "1.370" "1.156" "1.033" "1.519" "1.491" "0.560" "0.885" "1.618" "17.2" "23.5" "23.6" "19.9" "17.8" "26.2" "25.7" "9.6" "15.2" "27.9" "" "" "" "" "" "" "" "" "" "" "10.3" "12.2" "13.1" "9.3" "8.2" "13.4" "11.9" "4.3" "8.3" "27.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8858852225098701208" "False" "High" "IsMasterProtein" "P49642" "DNA primase small subunit OS=Homo sapiens OX=9606 GN=PRIM1 PE=1 SV=1" "0.002" "False" "3.117" "2" "1" "1" "1" "420" "49.9" "8.21" "2.67" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf01896" "5557" "ENSG00000198056" "PRIM1" "hsa:5557; P49642" "Retinoblastoma gene in cancer; Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Activation of the pre-replicative complex; Defective pyroptosis; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Telomere C-strand synthesis initiation; DNA replication initiation" "13" "0" "100.000" "100.000" "100.000" "100.000" "100.000" "100.000" "100.000" "100.000" "100.000" "0.0" "7.3" "7.7" "8.4" "7.3" "10.7" "6.1" "0.1" "4.7" "166.4" "" "" "" "" "" "" "" "" "" "" "0.0" "3.8" "4.3" "3.9" "3.4" "5.5" "2.8" "0.0" "2.5" "166.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "Not Found" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4974161228727514477" "False" "High" "IsMasterProtein" "Q9BS92" "Protein NipSnap homolog 3B OS=Homo sapiens OX=9606 GN=NIPSNAP3B PE=1 SV=1" "0.002" "False" "3.116" "5" "1" "1" "1" "247" "28.3" "9.28" "0.00" "1" "" "mitochondrion" "" "Pf07978" "55335" "ENSG00000165028" "NIPSNAP3B" "hsa:55335; Q5VX30; Q9BS92; Q9NUM2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4254593612476960216" "False" "High" "IsMasterProtein" "Q9BTZ2" "Dehydrogenase/reductase SDR family member 4 OS=Homo sapiens OX=9606 GN=DHRS4 PE=1 SV=3" "0.002" "False" "3.113" "3" "1" "1" "1" "278" "29.5" "8.56" "2.86" "1" "other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf13561" "10901" "ENSG00000157326; ENSG00000284807" "DHRS4" "B2RB10; B7WNS9; D3YTB8; E2QRL8; hsa:10901; O95162; Q20CR0; Q2LC19; Q2LE81; Q58IU4; Q6E0Y1; Q6UWU3; Q71UQ6; Q8TD03; Q9BTZ2; Q9H3N5; Q9NV08" "" "Peroxisomal protein import; RA biosynthesis pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7459111357476572255" "False" "High" "IsMasterProtein" "Q8NFY9" "Kelch repeat and BTB domain-containing protein 8 OS=Homo sapiens OX=9606 GN=KBTBD8 PE=1 SV=2" "0.002" "False" "3.112" "3" "2" "3" "2" "601" "68.8" "6.29" "2.41" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "" "Pf00651, Pf01344, Pf07707" "84541" "ENSG00000163376" "KBTBD8" "B4DTW6; hsa:84541; Q8NFY9; Q96JI5" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.823" "1.889" "1.380" "1.247" "1.388" "1.278" "0.720" "1.458" "4.924" "49.5" "90.2" "93.4" "68.3" "61.7" "68.7" "63.2" "35.6" "72.1" "243.6" "" "" "" "" "" "" "" "" "" "" "29.6" "46.9" "51.7" "32.1" "28.6" "35.2" "29.4" "16.0" "39.1" "243.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "727638957837399757" "False" "High" "IsMasterProtein" "O15014" "Zinc finger protein 609 OS=Homo sapiens OX=9606 GN=ZNF609 PE=1 SV=2" "0.002" "False" "3.110" "2" "1" "1" "1" "1411" "151.1" "8.03" "2.20" "1" "other biological processes" "nucleus" "other molecular function" "" "23060" "ENSG00000180357" "ZNF609" "hsa:23060; O15014; Q0D2I2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1604052202135203910" "False" "High" "IsMasterProtein" "O00592" "Podocalyxin OS=Homo sapiens OX=9606 GN=PODXL PE=1 SV=2" "0.002" "False" "3.109" "2" "1" "2" "1" "558" "58.6" "5.49" "4.16" "1" "cell adhesion;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "" "Pf06365" "5420" "ENSG00000128567" "PODXL" "A6NHX8; hsa:5420; O00592; Q52LZ7; Q53ER6" "Primary focal segmental glomerulosclerosis (FSGS); Ectoderm differentiation; Hepatitis C and hepatocellular carcinoma; Nephrotic syndrome; Pleural mesothelioma" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9189940377941500292" "False" "High" "IsMasterProtein" "Q9Y3D6" "Mitochondrial fission 1 protein OS=Homo sapiens OX=9606 GN=FIS1 PE=1 SV=2" "0.002" "False" "3.108" "9" "1" "1" "1" "152" "16.9" "8.79" "4.03" "1" "cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf14852, Pf14853" "51024" "ENSG00000214253" "FIS1" "hsa:51024; Q9BTP3; Q9Y3D6" "CAMKK2 pathway" "Class I peroxisomal membrane protein import" "2" "0" "1.195" "0.951" "1.447" "1.528" "1.146" "1.547" "1.237" "1.268" "1.004" "128.6" "153.6" "122.3" "186.0" "196.5" "147.4" "198.8" "159.1" "163.0" "129.1" "" "" "" "" "" "" "" "" "" "" "76.9" "79.8" "67.7" "87.3" "91.1" "75.4" "92.4" "71.4" "88.4" "129.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3678335116251458371" "False" "High" "IsMasterProtein" "P22670" "MHC class II regulatory factor RFX1 OS=Homo sapiens OX=9606 GN=RFX1 PE=1 SV=2" "0.002" "False" "3.107" "1" "1" "4" "1" "979" "104.7" "6.29" "7.92" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257, Pf04589" "5989" "ENSG00000132005; ENSG00000288283" "RFX1" "hsa:5989; P22670" "Alstrom syndrome" "" "1" "0" "1.094" "1.428" "1.408" "0.982" "1.072" "1.486" "1.270" "1.439" "1.245" "20.2" "22.1" "28.9" "28.5" "19.9" "21.7" "30.1" "25.7" "29.1" "25.2" "" "" "" "" "" "" "" "" "" "" "12.1" "11.5" "16.0" "13.4" "9.2" "11.1" "14.0" "11.5" "15.8" "25.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3666835465541347575" "False" "High" "IsMasterProtein" "Q14684" "Ribosomal RNA processing protein 1 homolog B OS=Homo sapiens OX=9606 GN=RRP1B PE=1 SV=3" "0.002" "False" "3.107" "1" "1" "1" "1" "758" "84.4" "9.76" "2.39" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05997" "23076" "ENSG00000160208" "RRP1B" "hsa:23076; Q14684; Q8TBZ4" "" "" "0" "0" "0.864" "0.621" "1.135" "1.034" "0.962" "0.915" "0.772" "1.008" "0.889" "37.2" "32.1" "23.1" "42.2" "38.4" "35.8" "34.0" "28.7" "37.5" "33.0" "" "" "" "" "" "" "" "" "" "" "22.2" "16.7" "12.8" "19.8" "17.8" "18.3" "15.8" "12.9" "20.3" "33.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3724111757375065163" "False" "High" "IsMasterProtein" "Q9P0W2" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related OS=Homo sapiens OX=9606 GN=HMG20B PE=1 SV=1" "0.002" "False" "3.105" "3" "1" "1" "1" "317" "35.8" "9.35" "2.35" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00505" "10362" "ENSG00000064961" "HMG20B" "A6NMS5; D6W616; hsa:10362; Q6IBP8; Q8NBD5; Q9HD21; Q9P0W2; Q9Y491; Q9Y4A2" "" "Factors involved in megakaryocyte development and platelet production; Potential therapeutics for SARS; HDACs deacetylate histones" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "141620358562250456" "False" "High" "IsMasterProtein" "Q8NCB2" "CaM kinase-like vesicle-associated protein OS=Homo sapiens OX=9606 GN=CAMKV PE=1 SV=2" "0.002" "False" "3.089" "3" "1" "1" "1" "501" "54.3" "5.55" "1.65" "1" "other biological processes" "plasma membrane;other membranes;other cell component" "kinase activity;other molecular function" "Pf00069" "79012" "ENSG00000164076" "CAMKV" "A6NFD4; hsa:79012; Q6FIB8; Q8NBS8; Q8NC85; Q8NCB2; Q8NDU4; Q8WTT8; Q9BQC9; Q9H0Q5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4293780430971367314" "False" "High" "IsMasterProtein" "Q13371" "Phosducin-like protein OS=Homo sapiens OX=9606 GN=PDCL PE=1 SV=3" "0.002" "False" "3.088" "4" "1" "1" "1" "301" "34.3" "4.73" "2.09" "1" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf02114" "5082" "ENSG00000136940" "PDCL" "hsa:5082; Q13371; Q4VXB6; Q96AF1; Q9UEW7; Q9UFL0; Q9UNX1; Q9UNX2" "" "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" "1" "0" "1.269" "1.164" "1.387" "1.047" "1.257" "1.178" "0.862" "1.093" "2.618" "22.7" "28.8" "26.5" "31.5" "23.8" "28.6" "26.8" "19.6" "24.8" "59.5" "" "" "" "" "" "" "" "" "" "" "13.6" "15.0" "14.6" "14.8" "11.0" "14.6" "12.4" "8.8" "13.5" "59.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4773466302739239443" "False" "High" "IsMasterProtein" "Q8IYA6" "Cytoskeleton-associated protein 2-like OS=Homo sapiens OX=9606 GN=CKAP2L PE=1 SV=4" "0.002" "False" "3.084" "2" "1" "1" "1" "745" "83.5" "9.83" "2.37" "1" "" "cytosol;cytoskeleton" "" "Pf15297" "150468" "ENSG00000169607" "CKAP2L" "A8K915; B4DZE3; B7ZAC6; F5H0M5; hsa:150468; Q53QF8; Q53RS8; Q8IYA6; Q8N1J8" "2q13 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5028999113090776511" "False" "High" "IsMasterProtein" "Q8WVB6" "Chromosome transmission fidelity protein 18 homolog OS=Homo sapiens OX=9606 GN=CHTF18 PE=1 SV=1" "0.002" "False" "3.079" "2" "1" "1" "1" "975" "107.3" "7.21" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00004" "63922" "ENSG00000127586" "CHTF18" "B7ZBA2; D3DU68; hsa:63922; Q7Z6Y4; Q7Z6Y6; Q8WVB6; Q9BR83; Q9BRG5; Q9H7K3" "Gastric cancer network 2; 7q11.23 copy number variation syndrome" "Polymerase switching on the C-strand of the telomere" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1562013219529803649" "False" "High" "IsMasterProtein" "P15391" "B-lymphocyte antigen CD19 OS=Homo sapiens OX=9606 GN=CD19 PE=1 SV=6" "0.002" "False" "3.076" "3" "1" "1" "1" "556" "61.1" "4.98" "0.00" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "" "" "930" "ENSG00000177455" "CD19" "A0N0P9; F5H635; hsa:930; P15391; Q96S68; Q9BRD6" "B cell receptor signaling pathway; Complement system; PI3K-Akt signaling pathway; Leukocyte-intrinsic Hippo pathway functions; 16p11.2 distal deletion syndrome; Extrafollicular and follicular B cell activation by SARS-CoV-2; 11p11.2 copy number variation syndrome" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-621581403936215319" "False" "High" "IsMasterProtein" "Q96B36" "Proline-rich AKT1 substrate 1 OS=Homo sapiens OX=9606 GN=AKT1S1 PE=1 SV=1" "0.002" "False" "3.071" "6" "1" "2" "1" "256" "27.4" "4.75" "0.00" "1" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf15798" "84335" "ENSG00000204673" "AKT1S1" "A8MTQ1; B2RE93; hsa:84335; J3KPM3; Q96B36; Q96BI4; Q96IK7; Q96NG2; Q9BWR5" "Target of rapamycin signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; Thermogenesis; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Thyroid hormones production and peripheral downstream signaling effects; Autophagy; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; p53 transcriptional gene network; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; JAK-STAT signaling in the regulation of beta cells; ADHD and autism (ASD) linked metabolic pathways and SNP" "HSF1-dependent transactivation; Constitutive Signaling by AKT1 E17K in Cancer; mTORC1-mediated signalling; AKT phosphorylates targets in the cytosol" "22" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5476878865190536687" "False" "High" "IsMasterProtein" "Q14693" "Phosphatidate phosphatase LPIN1 OS=Homo sapiens OX=9606 GN=LPIN1 PE=1 SV=2" "0.002" "False" "3.071" "3" "1" "1" "1" "890" "98.6" "6.58" "2.38" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf04571, Pf08235, Pf16876" "23175" "ENSG00000134324" "LPIN1" "A8MU38; B4DET9; B4DGS4; B4DGZ6; B5MC18; B7Z858; D6W506; E7ESE7; F5GY24; hsa:23175; Q14693; Q53T25" "Sterol regulatory element-binding proteins (SREBP) signaling; Adipogenesis; Transcription factor regulation in adipogenesis; Congenital generalized lipodystrophy" "Triglyceride biosynthesis; Depolymerization of the Nuclear Lamina; Synthesis of PC; Synthesis of PE" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "High" "Not Found" "Not Found" "Not Found" "1" "" "3427861429656696180" "False" "High" "IsMasterProtein" "O95197" "Reticulon-3 OS=Homo sapiens OX=9606 GN=RTN3 PE=1 SV=2" "0.002" "False" "3.070" "1" "1" "2" "1" "1032" "112.5" "4.96" "3.04" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component" "" "Pf02453" "10313" "ENSG00000133318" "RTN3" "B3KQS2; B7Z308; B7Z4M0; F5H774; hsa:10313; O95197; Q147U9; Q496K2; Q53GN3; Q59EP0; Q5UEP2; Q6T930; Q7RTM7; Q7RTM8; Q7RTN3" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "Synaptic adhesion-like molecules" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7043432361938153889" "False" "High" "IsMasterProtein" "Q8NCP5" "Zinc finger and BTB domain-containing protein 44 OS=Homo sapiens OX=9606 GN=ZBTB44 PE=1 SV=1" "0.002" "False" "3.067" "2" "1" "1" "1" "570" "63.8" "6.61" "2.29" "1" "" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "29068" "ENSG00000196323" "ZBTB44" "hsa:29068; Q6IPT8; Q86VJ7; Q86XX5; Q8NCP5" "" "" "0" "0" "1.001" "0.848" "1.011" "0.973" "0.818" "0.732" "0.933" "0.896" "0.542" "72.8" "72.9" "61.7" "73.6" "70.8" "59.6" "53.3" "67.9" "65.2" "39.5" "" "" "" "" "" "" "" "" "" "" "43.6" "37.9" "34.2" "34.6" "32.8" "30.5" "24.8" "30.5" "35.4" "39.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6257643935121491465" "False" "High" "IsMasterProtein" "Q15120" "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial OS=Homo sapiens OX=9606 GN=PDK3 PE=1 SV=1" "0.002" "False" "3.066" "4" "1" "1" "1" "406" "46.9" "8.37" "2.43" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "mitochondrion;nucleus" "kinase activity;other molecular function" "Pf02518, Pf10436" "5165" "ENSG00000067992" "PDK3" "B4DXG6; hsa:5165; Q15120" "" "Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3851558283081104520" "False" "High" "IsMasterProtein" "Q14145" "Kelch-like ECH-associated protein 1 OS=Homo sapiens OX=9606 GN=KEAP1 PE=1 SV=2" "0.002" "False" "3.062" "2" "1" "1" "1" "624" "69.6" "6.44" "0.00" "1" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00651, Pf01344, Pf07707" "9817" "ENSG00000079999" "KEAP1" "B3KPD5; hsa:9817; Q14145; Q6LEP0; Q8WTX1; Q9BPY9" "Quercetin and Nf-kB / AP-1 induced apoptosis; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Hereditary leiomyomatosis and renal cell carcinoma pathway; NRF2-ARE regulation; Head and neck squamous cell carcinoma; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway" "Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Neddylation; KEAP1-NFE2L2 pathway; Potential therapeutics for SARS; Nuclear events mediated by NFE2L2" "16" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "High" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "High" "1" "" "-2132288438487461579" "False" "High" "IsMasterProtein" "Q9BV68" "E3 ubiquitin-protein ligase RNF126 OS=Homo sapiens OX=9606 GN=RNF126 PE=1 SV=2" "0.002" "False" "3.053" "3" "1" "1" "1" "311" "33.8" "5.47" "2.48" "1" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13639, Pf14369" "55658" "ENSG00000070423" "RNF126" "hsa:55658; Q9BV68; Q9NWX1" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400072782813286453" "False" "High" "IsMasterProtein" "P62424" "Large ribosomal subunit protein eL8 OS=Homo sapiens OX=9606 GN=RPL7A PE=1 SV=2" "0.002" "False" "3.052" "3" "1" "1" "1" "266" "30.0" "10.61" "3.12" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6130" "ENSG00000148303; ENSG00000280858" "RPL7A" "hsa:6130; P11518; P62424; Q5T8U4" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.846" "1.123" "1.065" "0.913" "1.068" "0.892" "0.800" "1.150" "0.555" "88.9" "75.2" "99.8" "94.7" "81.2" "94.9" "79.3" "71.1" "102.2" "49.3" "" "" "" "" "" "" "" "" "" "" "53.2" "39.1" "55.2" "44.4" "37.6" "48.6" "36.9" "31.9" "55.4" "49.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6543857744544751788" "False" "High" "IsMasterProtein" "P38571" "Lysosomal acid lipase/cholesteryl ester hydrolase OS=Homo sapiens OX=9606 GN=LIPA PE=1 SV=2" "0.002" "False" "3.047" "3" "1" "1" "1" "399" "45.4" "6.92" "2.50" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00561" "3988" "ENSG00000107798" "LIPA" "B2RBH5; D3DR29; hsa:3988; P38571; Q16529; Q53H21; Q5T074; Q5T771; Q96EJ0" "Phase I biotransformations, non-P450; Degradation pathway of sphingolipids, including diseases; Cholesterol metabolism" "LDL clearance" "4" "0" "0.787" "0.940" "0.941" "0.750" "0.951" "1.146" "0.708" "0.959" "0.537" "37.7" "29.7" "35.5" "35.5" "28.3" "35.9" "43.2" "26.7" "36.2" "20.3" "" "" "" "" "" "" "" "" "" "" "22.6" "15.4" "19.6" "16.7" "13.1" "18.4" "20.1" "12.0" "19.6" "20.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6950247271112546932" "False" "High" "IsMasterProtein" "Q9H3N1" "Thioredoxin-related transmembrane protein 1 OS=Homo sapiens OX=9606 GN=TMX1 PE=1 SV=1" "0.002" "False" "3.047" "8" "1" "1" "1" "280" "31.8" "4.98" "2.40" "1" "stress response;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00085" "81542" "ENSG00000139921" "TMX1" "B2R7A4; hsa:81542; Q8N487; Q8NBN5; Q9H3N1; Q9Y4T6" "" "" "0" "0" "1.159" "1.061" "1.740" "1.263" "1.335" "1.547" "1.451" "1.190" "0.769" "28.1" "32.5" "29.8" "48.8" "35.4" "37.5" "43.4" "40.7" "33.4" "21.6" "" "" "" "" "" "" "" "" "" "" "16.8" "16.9" "16.5" "22.9" "16.4" "19.2" "20.2" "18.3" "18.1" "21.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2412952300113516382" "False" "High" "IsMasterProtein" "Cont_P28800" "Alpha-2-antiplasmin OS=Bos taurus OX=9913 GN=SERPINF2 PE=1 SV=2" "0.002" "True" "3.045" "2" "1" "1" "1" "492" "54.7" "5.72" "2.52" "1" "stress response;other biological processes" "non-structural extracellular" "enzyme regulator activity" "Pf00079" "282522" "ENSBIXG00000029361; ENSBTAG00000020859" "SERPINF2" "A0A4W2DRH6; bta:282522; P28800" "Complement and coagulation cascades; Blood clotting cascade" "Platelet degranulation ; Dissolution of Fibrin Clot" "4" "0" "1.261" "1.255" "1.349" "0.963" "1.024" "1.141" "1.074" "1.048" "0.791" "46.5" "58.7" "58.4" "62.8" "44.8" "47.6" "53.1" "49.9" "48.8" "36.8" "" "" "" "" "" "" "" "" "" "" "27.8" "30.5" "32.3" "29.5" "20.8" "24.4" "24.7" "22.4" "26.5" "36.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4281551287497306931" "False" "High" "IsMasterProtein" "Q9Y2B9" "cAMP-dependent protein kinase inhibitor gamma OS=Homo sapiens OX=9606 GN=PKIG PE=1 SV=1" "0.002" "False" "3.044" "21" "1" "1" "1" "76" "7.9" "4.25" "1.96" "1" "other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf02827" "11142" "ENSG00000168734" "PKIG" "hsa:11142; Q9Y2B9" "Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "Not Found" "High" "High" "High" "1" "" "-6052535811300559173" "False" "High" "IsMasterProtein" "Q2NL82" "Pre-rRNA-processing protein TSR1 homolog OS=Homo sapiens OX=9606 GN=TSR1 PE=1 SV=1" "0.002" "False" "3.043" "2" "1" "2" "1" "804" "91.8" "7.42" "4.02" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04950, Pf08142" "55720" "ENSG00000167721" "TSR1" "hsa:55720; Q2NL82; Q8WUY5; Q9NVT0; Q9P2E6" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4234558439794556747" "False" "High" "IsMasterProtein" "Q8N6H7" "ADP-ribosylation factor GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=ARFGAP2 PE=1 SV=1" "0.002" "False" "3.041" "2" "1" "1" "1" "521" "56.7" "7.99" "2.72" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf01412" "84364" "ENSG00000149182" "ARFGAP2" "B4DX29; B7Z9M7; D3DQQ9; hsa:84364; Q3LIF2; Q8N3I1; Q8N6H7; Q96SX7" "IL-18 signaling pathway; 5q35 copy number variation" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; CDC42 GTPase cycle" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3568941862227660384" "False" "High" "IsMasterProtein" "Q9NVP2" "Histone chaperone ASF1B OS=Homo sapiens OX=9606 GN=ASF1B PE=1 SV=1" "0.002" "False" "3.034" "4" "1" "2" "1" "202" "22.4" "4.56" "4.53" "1" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04729" "55723" "ENSG00000105011; ENSG00000288210" "ASF1B" "hsa:55723; Q53G51; Q9NVP2; Q9NVZ0" "" "" "0" "0" "1.199" "1.242" "1.045" "1.176" "1.030" "1.134" "0.591" "1.117" "4.066" "81.9" "98.2" "101.6" "85.6" "96.3" "84.3" "92.9" "48.3" "91.4" "332.8" "" "" "" "" "" "" "" "" "" "" "49.0" "51.0" "56.3" "40.2" "44.6" "43.2" "43.2" "21.7" "49.6" "332.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2926679715344885449" "False" "High" "IsMasterProtein" "O94913" "Pre-mRNA cleavage complex 2 protein Pcf11 OS=Homo sapiens OX=9606 GN=PCF11 PE=1 SV=3" "0.002" "False" "3.023" "1" "2" "2" "2" "1555" "172.9" "8.48" "0.00" "2" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04818, Pf11526, Pf20827, Pf20844, Pf20845" "51585" "ENSG00000165494" "PCF11" "A6H8W7; hsa:51585; O43671; O94913; Q6P0X8" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RNA polymerase II transcribes snRNA genes; Processing of Intronless Pre-mRNAs" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8579706144891720478" "False" "High" "IsMasterProtein" "O00267" "Transcription elongation factor SPT5 OS=Homo sapiens OX=9606 GN=SUPT5H PE=1 SV=1" "0.002" "False" "3.022" "1" "1" "1" "1" "1087" "120.9" "5.06" "2.60" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00467, Pf03439, Pf11942" "6829" "ENSG00000196235" "SUPT5H" "hsa:6829; O00267; O43279; Q59G52; Q99639" "Initiation of transcription and translation elongation at the HIV-1 LTR; mRNA processing" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "20" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7996952704107557877" "False" "High" "IsMasterProtein" "P28331" "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS1 PE=1 SV=3" "0.002" "False" "3.019" "1" "1" "1" "1" "727" "79.4" "6.23" "1.97" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00384, Pf09326, Pf10588, Pf13510" "4719" "ENSG00000023228; ENSG00000283447" "NDUFS1" "B4DIN9; B4DJA0; B4DPG1; B4DUC1; E7ENF3; hsa:4719; P28331; Q53TR8; Q8N1C4; Q8TCC9" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis; Mitochondrial protein degradation" "6" "0" "1.638" "1.063" "1.618" "1.442" "1.113" "1.403" "1.520" "0.900" "2.656" "24.9" "40.7" "26.4" "40.2" "35.9" "27.7" "34.9" "37.8" "22.4" "66.0" "" "" "" "" "" "" "" "" "" "" "14.9" "21.2" "14.6" "18.9" "16.6" "14.2" "16.2" "17.0" "12.1" "66.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1914895012756735579" "False" "High" "IsMasterProtein" "P08240" "Signal recognition particle receptor subunit alpha OS=Homo sapiens OX=9606 GN=SRPRA PE=1 SV=2" "0.002" "False" "3.016" "1" "1" "1" "1" "638" "69.8" "8.95" "2.19" "1" "cell organization and biogenesis;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00448, Pf02881, Pf04086" "6734" "ENSG00000182934" "SRPRA" "A6NIB3; B2R5Z8; B4E0H3; E9PJS4; hsa:6734; P08240; Q9BVJ4" "" "XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4655798141038654615" "False" "High" "IsMasterProtein" "Q8N6N3" "UPF0690 protein C1orf52 OS=Homo sapiens OX=9606 GN=C1orf52 PE=1 SV=1" "0.002" "False" "3.007" "8" "1" "1" "1" "182" "20.6" "5.21" "2.57" "1" "" "nucleus" "" "Pf15559" "148423" "ENSG00000162642" "C1orf52" "B3KX89; hsa:148423; Q8N6N3; Q8TDK5; Q8TDK6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-699838257049576232" "False" "High" "IsMasterProtein" "Q8IWC1" "MAP7 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=MAP7D3 PE=1 SV=2" "0.002" "False" "3.006" "1" "1" "1" "1" "876" "98.4" "9.32" "1.80" "1" "cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf05672" "79649" "ENSG00000129680" "MAP7D3" "A2A2J0; A6NCZ7; A6NHR4; B4DWD2; H7BY77; hsa:79649; Q5JXI5; Q5JXI6; Q6P2S1; Q8IWC1; Q9H9M8" "" "" "0" "0" "0.980" "1.267" "1.103" "0.831" "1.244" "1.219" "1.019" "1.091" "1.162" "23.3" "22.8" "29.5" "25.7" "19.3" "28.9" "28.4" "23.7" "25.4" "27.0" "" "" "" "" "" "" "" "" "" "" "13.9" "11.8" "16.3" "12.0" "9.0" "14.8" "13.2" "10.6" "13.8" "27.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8818107332528144144" "False" "High" "IsMasterProtein" "Q9H4E7" "Differentially expressed in FDCP 6 homolog OS=Homo sapiens OX=9606 GN=DEF6 PE=1 SV=1" "0.002" "False" "3.005" "2" "1" "1" "1" "631" "73.9" "6.05" "2.01" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00169" "50619" "ENSG00000023892" "DEF6" "hsa:50619; Q86VF4; Q9H4E7" "" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle" "4" "0" "1.018" "0.985" "0.649" "0.986" "1.169" "1.312" "0.654" "0.761" "3.249" "18.3" "18.7" "18.1" "11.9" "18.1" "21.4" "24.1" "12.0" "14.0" "59.6" "" "" "" "" "" "" "" "" "" "" "11.0" "9.7" "10.0" "5.6" "8.4" "11.0" "11.2" "5.4" "7.6" "59.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9099415838211122916" "False" "High" "IsMasterProtein" "P33981" "Dual specificity protein kinase TTK OS=Homo sapiens OX=9606 GN=TTK PE=1 SV=2" "0.002" "False" "3.003" "2" "1" "1" "1" "857" "97.0" "8.16" "2.32" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "7272" "ENSG00000112742" "TTK" "A8K8U5; B2RDW2; E1P543; hsa:7272; P33981; Q15272; Q5TCS0; Q9BW51; Q9NTM0" "Cell cycle; Retinoblastoma gene in cancer" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "715968340642640214" "False" "High" "IsMasterProtein" "Q9H9A6" "Leucine-rich repeat-containing protein 40 OS=Homo sapiens OX=9606 GN=LRRC40 PE=1 SV=1" "0.002" "False" "3.003" "2" "1" "1" "1" "602" "68.2" "6.43" "1.99" "1" "signal transduction" "" "" "Pf00560, Pf13855" "55631" "ENSG00000066557" "LRRC40" "hsa:55631; Q9BTR7; Q9H9A6; Q9NSK1; Q9NXC1" "" "" "0" "0" "0.737" "0.832" "0.964" "0.793" "0.961" "0.878" "0.645" "0.931" "2.331" "52.7" "38.8" "43.8" "50.7" "41.8" "50.6" "46.2" "33.9" "49.0" "122.8" "" "" "" "" "" "" "" "" "" "" "31.5" "20.2" "24.3" "23.8" "19.4" "25.9" "21.5" "15.2" "26.6" "122.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2552389438880602085" "False" "High" "IsMasterProtein" "Q7L5Y1" "Mitochondrial enolase superfamily member 1 OS=Homo sapiens OX=9606 GN=ENOSF1 PE=1 SV=1" "0.002" "False" "3.000" "2" "1" "1" "1" "443" "49.8" "6.48" "2.03" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf02746, Pf13378" "55556" "ENSG00000132199" "ENOSF1" "A6NMP3; A8K9R5; B3KSL6; B3KXE4; D3DUH0; hsa:55556; Q15407; Q15594; Q15595; Q6ZS08; Q7L5Y1; Q9HAS5; Q9HAS6" "" "" "0" "0" "0.906" "0.720" "0.899" "0.983" "0.936" "0.975" "0.927" "0.743" "0.752" "72.9" "66.0" "52.5" "65.5" "71.7" "68.2" "71.0" "67.6" "54.2" "54.8" "" "" "" "" "" "" "" "" "" "" "43.6" "34.3" "29.1" "30.8" "33.2" "34.9" "33.0" "30.3" "29.4" "54.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5015349167503174310" "False" "High" "IsMasterProtein" "Q8NCC3" "Lysosomal phospholipase A and acyltransferase OS=Homo sapiens OX=9606 GN=PLA2G15 PE=1 SV=2" "0.002" "False" "3.000" "3" "1" "1" "1" "412" "46.6" "6.73" "3.18" "1" "other metabolic processes" "non-structural extracellular;other membranes;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02450" "23659" "ENSG00000103066" "PLA2G15" "B3KMF3; B4DUD1; hsa:23659; Q53GZ1; Q8NCC3; Q9NPQ6; Q9UG04; Q9Y2B3" "" "Hydrolysis of LPC" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8769135798573244061" "False" "High" "IsMasterProtein" "P35658" "Nuclear pore complex protein Nup214 OS=Homo sapiens OX=9606 GN=NUP214 PE=1 SV=2" "0.002" "False" "2.999" "0" "1" "1" "1" "2090" "213.5" "7.47" "2.18" "1" "other metabolic processes;transport;other biological processes" "cytosol;nucleus" "other molecular function" "Pf18617" "8021" "ENSG00000126883" "NUP214" "A6NFQ0; hsa:8021; P35658; Q15010; Q3KQZ0; Q5JUP7; Q75R47; Q86XD3" "TGF-beta signaling pathway" "Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HuR (ELAVL1) binds and stabilizes mRNA" "30" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6176732133664384368" "False" "High" "IsMasterProtein" "Q70CQ2" "Ubiquitin carboxyl-terminal hydrolase 34 OS=Homo sapiens OX=9606 GN=USP34 PE=1 SV=2" "0.002" "False" "2.999" "0" "1" "1" "1" "3546" "404.0" "5.82" "2.10" "1" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00443, Pf12030" "9736" "ENSG00000115464" "USP34" "A8MWD0; B3KWU9; hsa:9736; O60316; O94834; Q3B777; Q6P6C9; Q70CQ2; Q7L8P6; Q8N3T9; Q8TBW2; Q9UGA1" "" "Ub-specific processing proteases; TCF dependent signaling in response to WNT" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5042642415102067907" "False" "High" "IsMasterProtein" "Q99549" "M-phase phosphoprotein 8 OS=Homo sapiens OX=9606 GN=MPHOSPH8 PE=1 SV=2" "0.002" "False" "2.995" "2" "1" "1" "1" "860" "97.1" "6.06" "0.00" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00385, Pf12796" "54737" "ENSG00000196199" "MPHOSPH8" "B7Z6F9; hsa:54737; Q5JPE5; Q5JTQ0; Q86TK3; Q96MK4; Q99549; Q9BTP1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5259083941231079932" "False" "High" "IsMasterProtein" "Q7Z4G1" "COMM domain-containing protein 6 OS=Homo sapiens OX=9606 GN=COMMD6 PE=1 SV=1" "0.002" "False" "2.995" "11" "1" "1" "1" "85" "9.6" "6.00" "2.63" "1" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf07258" "170622" "ENSG00000188243" "COMMD6" "A6NF28; B7ZLN0; hsa:170622; Q5TBK4; Q7Z4G1" "" "Neddylation" "1" "0" "0.991" "0.993" "1.666" "1.136" "0.809" "1.053" "1.052" "1.155" "1.097" "18.2" "18.1" "18.1" "30.4" "20.7" "14.7" "19.2" "19.2" "21.0" "20.0" "" "" "" "" "" "" "" "" "" "" "10.9" "9.4" "10.0" "14.3" "9.6" "7.6" "8.9" "8.6" "11.4" "20.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1264593624988505849" "False" "High" "IsMasterProtein" "Q14694" "Ubiquitin carboxyl-terminal hydrolase 10 OS=Homo sapiens OX=9606 GN=USP10 PE=1 SV=2" "0.002" "False" "2.989" "2" "2" "2" "2" "798" "87.1" "5.31" "1.73" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00443, Pf07145" "9100" "ENSG00000103194" "USP10" "B2RDJ8; B4DS84; hsa:9100; Q14694; Q9BWG7; Q9NSL7" "VEGFA-VEGFR2 signaling" "Ub-specific processing proteases; Termination of translesion DNA synthesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3084200639085863850" "False" "High" "IsMasterProtein" "O14497" "AT-rich interactive domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ARID1A PE=1 SV=3" "0.002" "False" "2.982" "1" "2" "2" "2" "2285" "241.9" "6.70" "0.00" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01388, Pf12031" "8289" "ENSG00000117713" "ARID1A" "D3DPL1; hsa:8289; O14497; Q53FK9; Q5T0W1; Q5T0W2; Q5T0W3; Q8NFD6; Q96T89; Q9BY33; Q9HBJ5; Q9UPZ1" "Androgen receptor network in prostate cancer; Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2256308892199755457" "False" "High" "IsMasterProtein" "Q969J3" "BLOC-1-related complex subunit 5 OS=Homo sapiens OX=9606 GN=BORCS5 PE=1 SV=1" "0.002" "False" "2.981" "8" "1" "1" "1" "196" "22.2" "6.35" "2.66" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf10158" "118426" "ENSG00000165714; ENSG00000280689" "BORCS5" "hsa:118426; Q969J3; Q96QS5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4633988099481439098" "False" "High" "IsMasterProtein" "Q9Y5T5" "Ubiquitin carboxyl-terminal hydrolase 16 OS=Homo sapiens OX=9606 GN=USP16 PE=1 SV=1" "0.002" "False" "2.981" "2" "1" "1" "1" "823" "93.5" "6.93" "2.70" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "translation activity;other molecular function" "Pf00443, Pf02148" "10600" "ENSG00000156256; ENSG00000291527" "USP16" "A8MU43; B3KN13; B4DFV8; B4DY37; D3DSD9; hsa:10600; Q53GP7; Q53HA0; Q5VKN8; Q8NEL3; Q9H3E6; Q9Y5T5" "" "Ub-specific processing proteases" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7973916192928746401" "False" "High" "IsMasterProtein" "Q8N6N7" "Acyl-CoA-binding domain-containing protein 7 OS=Homo sapiens OX=9606 GN=ACBD7 PE=1 SV=1" "0.002" "False" "2.978" "10" "1" "1" "1" "88" "9.8" "6.71" "3.55" "1" "other metabolic processes" "" "other molecular function" "Pf00887" "414149" "ENSG00000176244" "ACBD7" "A6NCI2; B3KTG8; hsa:414149; Q8N6N7" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6512701136026714686" "False" "High" "IsMasterProtein" "O95379" "Tumor necrosis factor alpha-induced protein 8 OS=Homo sapiens OX=9606 GN=TNFAIP8 PE=1 SV=1" "0.002" "False" "2.975" "4" "1" "1" "1" "198" "23.0" "7.93" "2.69" "1" "other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf05527" "25816" "ENSG00000145779" "TNFAIP8" "B3KMH1; B3KMI2; B7Z713; hsa:25816; O95379; Q9P1Q1; Q9UER5; Q9UP47" "" "PI Metabolism" "1" "0" "0.972" "0.981" "0.784" "0.782" "0.972" "0.769" "0.952" "0.815" "1.053" "186.3" "181.2" "182.8" "146.2" "145.7" "181.2" "143.3" "177.4" "151.8" "196.3" "" "" "" "" "" "" "" "" "" "" "111.5" "94.2" "101.3" "68.6" "67.5" "92.8" "66.6" "79.6" "82.4" "196.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "123318016964233677" "False" "High" "IsMasterProtein" "O75489" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS3 PE=1 SV=1" "0.002" "False" "2.973" "5" "1" "2" "1" "264" "30.2" "7.50" "2.71" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion;nucleus" "transporter activity;other molecular function" "Pf00329" "4722" "ENSG00000213619" "NDUFS3" "B2R9J1; B4DFM8; hsa:4722; O75489; Q9UNQ8" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "RHOG GTPase cycle; Complex I biogenesis; Mitochondrial protein degradation" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9022416781062355686" "False" "High" "IsMasterProtein" "Q9UPU5" "Ubiquitin carboxyl-terminal hydrolase 24 OS=Homo sapiens OX=9606 GN=USP24 PE=1 SV=3" "0.002" "False" "2.972" "0" "1" "1" "1" "2620" "294.2" "6.14" "2.25" "1" "protein metabolism" "cytosol;nucleus" "other molecular function" "Pf00443" "23358" "ENSG00000162402" "USP24" "hsa:23358; Q6ZSY2; Q8N2Y4; Q9NXD1; Q9UPU5" "" "Ub-specific processing proteases" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1618235937448484575" "False" "High" "IsMasterProtein" "P04839" "Cytochrome b-245 heavy chain OS=Homo sapiens OX=9606 GN=CYBB PE=1 SV=2" "0.002" "False" "2.966" "2" "1" "1" "1" "570" "65.3" "8.63" "2.11" "1" "other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01794, Pf08022, Pf08030" "1536" "ENSG00000165168" "CYBB" "A8K138; hsa:1536; P04839; Q2PP16" "Alzheimer's disease and miRNA effects; VEGFA-VEGFR2 signaling; Microglia pathogen phagocytosis pathway; Oxidative stress response; Ferroptosis; Alzheimer's disease; Urotensin-II-mediated signaling pathway; Genetic causes of porto-sinusoidal vascular disease; HDAC6 interactions in the central nervous system; Type II interferon signaling" "Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Detoxification of Reactive Oxygen Species; VEGFA-VEGFR2 Pathway; ROS and RNS production in phagocytes; Cross-presentation of particulate exogenous antigens (phagosomes); RHO GTPases Activate NADPH Oxidases" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "High" "High" "Not Found" "High" "High" "High" "Not Found" "High" "1" "" "-651184813655133351" "False" "High" "IsMasterProtein" "P13807" "Glycogen [starch] synthase, muscle OS=Homo sapiens OX=9606 GN=GYS1 PE=1 SV=2" "0.002" "False" "2.961" "1" "1" "1" "1" "737" "83.7" "6.18" "2.49" "1" "other metabolic processes;developmental processes" "cytosol;other cell component" "other molecular function" "Pf05693" "2997" "ENSG00000104812" "GYS1" "hsa:2997; P13807; Q9BTT9" "AMP-activated protein kinase signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Insulin signaling; Glycogen synthesis and degradation; Disorders of galactose metabolism ; 2q37 copy number variation syndrome" "Glycogen synthesis; Myoclonic epilepsy of Lafora; Glycogen storage disease type XV (GYG1); Glycogen storage disease type 0 (muscle GYS1)" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3774842769131475239" "False" "High" "IsMasterProtein" "Q9Y2R5" "Small ribosomal subunit protein uS17m OS=Homo sapiens OX=9606 GN=MRPS17 PE=1 SV=1" "0.002" "False" "2.955" "8" "1" "1" "1" "130" "14.5" "9.85" "2.07" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity" "Pf00366" "51373" "ENSG00000239789" "MRPS17" "hsa:51373; Q86X15; Q9Y2R5" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.252" "0.946" "1.480" "1.499" "1.170" "1.141" "1.201" "1.173" "1.949" "18.3" "23.0" "17.3" "27.2" "27.5" "21.5" "20.9" "22.0" "21.5" "35.8" "" "" "" "" "" "" "" "" "" "" "11.0" "11.9" "9.6" "12.7" "12.7" "11.0" "9.7" "9.9" "11.7" "35.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3626479859969264661" "False" "High" "IsMasterProtein" "Q96QG7" "Myotubularin-related protein 9 OS=Homo sapiens OX=9606 GN=MTMR9 PE=1 SV=1" "0.002" "False" "2.951" "1" "1" "1" "1" "549" "63.4" "6.39" "3.07" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf06602, Pf21098" "66036" "ENSG00000104643; ENSG00000285032" "MTMR9" "B7Z291; hsa:66036; Q52LU3; Q8WW11; Q96QG6; Q96QG7; Q9NX50" "8p23.1 copy number variation syndrome" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the late endosome membrane; Synthesis of IP2, IP, and Ins in the cytosol" "4" "0" "1.474" "1.396" "1.542" "1.457" "1.445" "1.452" "1.306" "1.480" "3.084" "63.2" "93.2" "88.3" "97.4" "92.1" "91.3" "91.8" "82.6" "93.6" "195.0" "" "" "" "" "" "" "" "" "" "" "37.8" "48.4" "48.9" "45.7" "42.7" "46.7" "42.7" "37.1" "50.8" "195.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6887775823956767803" "False" "High" "IsMasterProtein" "P25440" "Bromodomain-containing protein 2 OS=Homo sapiens OX=9606 GN=BRD2 PE=1 SV=2" "0.002" "False" "2.945" "2" "1" "1" "1" "801" "88.0" "9.09" "1.93" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00439, Pf17035" "6046" "ENSG00000204256; ENSG00000215077; ENSG00000234507; ENSG00000234704; ENSG00000235307" "BRD2" "A2AAU0; B0S7P0; B1AZT1; O00699; O00700; P25440; Q15310; Q5STC9; Q63HQ9; Q658Y7; Q6P3U2; Q969U4" "" "RUNX3 regulates p14-ARF" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "Not Found" "High" "Not Found" "Not Found" "High" "High" "High" "1" "" "4723246947420564514" "False" "High" "IsMasterProtein" "O94915" "Protein furry homolog-like OS=Homo sapiens OX=9606 GN=FRYL PE=1 SV=2" "0.002" "False" "2.943" "0" "1" "1" "1" "3013" "339.4" "5.58" "2.03" "1" "cell organization and biogenesis;developmental processes;other biological processes" "other cell component" "" "Pf14222, Pf14225, Pf14228, Pf19421" "285527" "ENSG00000075539" "FRYL" "hsa:285527; O94915; O95640; Q8WTZ5; Q9NT40" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4711793945183504944" "False" "High" "IsMasterProtein" "P23434" "Glycine cleavage system H protein, mitochondrial OS=Homo sapiens OX=9606 GN=GCSH PE=1 SV=2" "0.002" "False" "2.938" "12" "1" "2" "1" "173" "18.9" "4.88" "0.00" "1" "protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01597" "2653" "ENSG00000140905; ENSG00000291958" "GCSH" "hsa:2653; P23434; Q9H1E9" "" "Glycine degradation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4791788072284182717" "False" "High" "IsMasterProtein" "Q96GM5" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 OS=Homo sapiens OX=9606 GN=SMARCD1 PE=1 SV=2" "0.002" "False" "2.938" "3" "1" "1" "1" "515" "58.2" "9.25" "2.35" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02201" "6602" "ENSG00000066117" "SMARCD1" "A6NN27; hsa:6602; Q92924; Q96GM5; Q9Y635" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "Not Found" "High" "Not Found" "Not Found" "Not Found" "High" "Not Found" "High" "1" "" "-586751030658289178" "False" "High" "IsMasterProtein" "Q9NZ53" "Podocalyxin-like protein 2 OS=Homo sapiens OX=9606 GN=PODXL2 PE=1 SV=1" "0.002" "False" "2.938" "2" "1" "1" "1" "605" "65.0" "4.34" "2.89" "1" "cell adhesion" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf06365" "50512" "ENSG00000114631" "PODXL2" "hsa:50512; Q6UVY4; Q8WUV6; Q9NZ53" "" "Cytosolic sulfonation of small molecules" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-580559568770530829" "False" "High" "IsMasterProtein" "Q14135" "Transcription cofactor vestigial-like protein 4 OS=Homo sapiens OX=9606 GN=VGLL4 PE=1 SV=4" "0.002" "False" "2.933" "4" "1" "1" "1" "290" "30.9" "8.22" "3.15" "1" "other biological processes" "nucleus" "other molecular function" "Pf15245" "9686" "ENSG00000144560" "VGLL4" "B4DTS7; hsa:9686; J3KN68; Q14135; Q7L5V0; Q9BQ78" "Hippo-Merlin signaling dysregulation; Pleural mesothelioma" "" "2" "0" "1.026" "1.066" "1.164" "1.257" "1.211" "1.145" "1.093" "1.067" "0.674" "97.6" "100.2" "104.0" "113.7" "122.7" "118.2" "111.8" "106.7" "104.2" "65.8" "" "" "" "" "" "" "" "" "" "" "58.4" "52.1" "57.6" "53.4" "56.9" "60.5" "52.0" "47.9" "56.5" "65.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7714600249941919632" "False" "High" "IsMasterProtein" "O95562" "Vesicle transport protein SFT2B OS=Homo sapiens OX=9606 GN=SFT2D2 PE=1 SV=1" "0.002" "False" "2.933" "6" "1" "1" "1" "160" "17.8" "9.13" "2.53" "1" "transport" "other membranes" "" "Pf04178" "375035" "ENSG00000213064" "SFT2D2" "A8K2R0; hsa:375035; O95562; Q6UWR8" "TYROBP causal network in microglia" "" "1" "0" "1.050" "0.832" "0.739" "0.979" "1.004" "0.863" "1.176" "1.029" "0.784" "79.2" "83.2" "65.9" "58.5" "77.5" "79.5" "68.4" "93.1" "81.5" "62.1" "" "" "" "" "" "" "" "" "" "" "47.4" "43.2" "36.5" "27.5" "35.9" "40.7" "31.8" "41.8" "44.2" "62.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6142144855289123481" "False" "High" "IsMasterProtein" "Q96HC4" "PDZ and LIM domain protein 5 OS=Homo sapiens OX=9606 GN=PDLIM5 PE=1 SV=5" "0.002" "False" "2.931" "3" "1" "1" "1" "596" "63.9" "8.21" "2.10" "1" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595" "10611" "ENSG00000163110" "PDLIM5" "A8K6F9; D6RB78; E9PBF5; hsa:10611; O60705; Q56VN4; Q5UW38; Q8WVK0; Q96HC4" "Extracellular vesicles in the crosstalk of cardiac cells" "Neurexins and neuroligins" "2" "0" "1.494" "1.810" "1.694" "1.250" "1.719" "1.671" "2.065" "1.783" "1.747" "16.1" "24.0" "29.1" "27.2" "20.1" "27.6" "26.8" "33.2" "28.6" "28.1" "" "" "" "" "" "" "" "" "" "" "9.6" "12.5" "16.1" "12.8" "9.3" "14.1" "12.5" "14.9" "15.5" "28.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4842637441270179392" "False" "High" "IsMasterProtein" "Q9BU76" "Multiple myeloma tumor-associated protein 2 OS=Homo sapiens OX=9606 GN=MMTAG2 PE=1 SV=1" "0.002" "False" "2.927" "3" "1" "1" "1" "263" "29.4" "10.02" "2.77" "1" "" "non-structural extracellular;other cell component" "" "Pf10159" "79169" "ENSG00000143793" "MMTAG2" "hsa:79169; Q6P5Y0; Q6ZTZ6; Q6ZWA6; Q8IZH3; Q9BU76" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6620394605716673272" "False" "High" "IsMasterProtein" "Q96GX2" "Ataxin-7-like protein 3B OS=Homo sapiens OX=9606 GN=ATXN7L3B PE=1 SV=2" "0.002" "False" "2.919" "10" "1" "1" "1" "97" "10.8" "4.36" "2.48" "1" "other biological processes" "other cell component" "" "" "552889" "ENSG00000253719" "ATXN7L3B" "hsa:552889; Q96GX2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1899154642705730358" "False" "High" "IsMasterProtein" "Q9UNK0" "Syntaxin-8 OS=Homo sapiens OX=9606 GN=STX8 PE=1 SV=2" "0.003" "False" "2.914" "4" "1" "1" "1" "236" "26.9" "4.98" "2.94" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739" "9482" "ENSG00000170310" "STX8" "hsa:9482; O60712; Q53XT8; Q9UNK0" "" "" "0" "0" "0.923" "0.740" "0.896" "0.884" "0.790" "0.838" "0.823" "0.987" "0.706" "45.8" "42.3" "33.9" "41.1" "40.5" "36.2" "38.4" "37.7" "45.2" "32.4" "" "" "" "" "" "" "" "" "" "" "27.4" "22.0" "18.8" "19.3" "18.8" "18.5" "17.9" "16.9" "24.5" "32.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "864324901755663317" "False" "High" "IsMasterProtein" "Q8TAP9" "M-phase-specific PLK1-interacting protein OS=Homo sapiens OX=9606 GN=MPLKIP PE=1 SV=1" "0.003" "False" "2.907" "14" "1" "1" "1" "179" "19.1" "10.23" "0.00" "1" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;ER/Golgi;nucleus;other cell component" "" "Pf15502" "136647" "ENSG00000168303" "MPLKIP" "hsa:136647; Q8TAP9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "Not Found" "Not Found" "Not Found" "High" "High" "Not Found" "High" "High" "1" "" "7197122219504261731" "False" "High" "IsMasterProtein" "Q96EK9" "Protein KTI12 homolog OS=Homo sapiens OX=9606 GN=KTI12 PE=1 SV=1" "0.003" "False" "2.906" "5" "1" "1" "1" "354" "38.6" "6.95" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf08433" "112970" "ENSG00000198841" "KTI12" "hsa:112970; Q96EK9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5517999105151406307" "False" "High" "IsMasterProtein" "Q9NWT1" "p21-activated protein kinase-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAK1IP1 PE=1 SV=2" "0.003" "False" "2.904" "2" "1" "1" "1" "392" "43.9" "8.91" "2.71" "1" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf00400" "55003" "ENSG00000111845; ENSG00000285226" "PAK1IP1" "hsa:55003; Q5T4J2; Q96QJ8; Q96T87; Q9NWT1" "" "" "0" "0" "1.163" "1.174" "0.832" "1.176" "0.911" "0.732" "0.941" "0.825" "1.152" "105.7" "122.9" "124.0" "87.9" "124.2" "96.2" "77.3" "99.4" "87.1" "121.7" "" "" "" "" "" "" "" "" "" "" "63.2" "63.9" "68.7" "41.2" "57.6" "49.3" "36.0" "44.6" "47.3" "121.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6202573485252222351" "False" "High" "IsMasterProtein" "Q9NZD2" "Glycolipid transfer protein OS=Homo sapiens OX=9606 GN=GLTP PE=1 SV=3" "0.003" "False" "2.900" "6" "1" "1" "1" "209" "23.8" "7.39" "2.55" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport" "cytosol" "transporter activity;other molecular function" "Pf08718" "51228" "ENSG00000139433" "GLTP" "hsa:51228; Q53Z13; Q96J68; Q9NZD2" "" "Glycosphingolipid transport" "1" "0" "1.093" "1.186" "1.225" "1.304" "1.144" "1.452" "0.769" "1.154" "2.059" "35.9" "39.2" "42.5" "44.0" "46.8" "41.0" "52.1" "27.6" "41.4" "73.8" "" "" "" "" "" "" "" "" "" "" "21.5" "20.4" "23.6" "20.6" "21.7" "21.0" "24.2" "12.4" "22.5" "73.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6133678444779992417" "False" "High" "IsMasterProtein" "Q9UGU0" "Transcription factor 20 OS=Homo sapiens OX=9606 GN=TCF20 PE=1 SV=3" "0.003" "False" "2.899" "1" "1" "1" "1" "1960" "211.6" "9.04" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13771" "6942" "ENSG00000100207; ENSG00000262024; ENSG00000276461" "TCF20" "A9JX12; hsa:6942; O14528; Q13078; Q4V353; Q9H4M0; Q9UGU0" "Matrix metalloproteinases" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "High" "Not Found" "High" "High" "High" "Not Found" "High" "Not Found" "1" "" "-8281195296370466031" "False" "High" "IsMasterProtein" "P0CG13" "Chromosome transmission fidelity protein 8 homolog OS=Homo sapiens OX=9606 GN=CHTF8 PE=1 SV=1" "0.003" "False" "2.891" "11" "1" "1" "1" "121" "13.3" "8.18" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf09696" "54921" "ENSG00000168802" "CHTF8" "A8MYX8; hsa:54921; P0CG13; Q71E72; Q8NDH8; Q8WV66; Q9NX73" "Gastric cancer network 2" "Polymerase switching on the C-strand of the telomere" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8286175184294444153" "False" "High" "IsMasterProtein" "A0AAG2TVC3" "Uncharacterized protein OS=Homo sapiens OX=9606 PE=4 SV=1" "0.003" "False" "2.882" "3" "1" "2" "1" "264" "28.0" "4.67" "5.95" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "1.045" "0.973" "0.980" "1.176" "0.954" "1.155" "1.071" "0.959" "1.309" "233.6" "244.0" "227.3" "228.9" "274.6" "222.8" "269.8" "250.1" "224.1" "305.8" "" "" "" "" "" "" "" "" "" "" "139.8" "126.8" "125.8" "107.5" "127.3" "114.1" "125.5" "112.3" "121.6" "305.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2163956888383823018" "False" "High" "IsMasterProtein" "Q96A65" "Exocyst complex component 4 OS=Homo sapiens OX=9606 GN=EXOC4 PE=1 SV=1" "0.003" "False" "2.881" "1" "1" "1" "1" "974" "110.4" "6.49" "2.16" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf04048, Pf20652" "60412" "ENSG00000131558" "EXOC4" "E9PED2; hsa:60412; Q541U8; Q96A65; Q9C0G4; Q9H9K0; Q9P102" "Ciliary landscape" "Insulin processing; Translocation of SLC2A4 (GLUT4) to the plasma membrane; VxPx cargo-targeting to cilium" "4" "0" "0.951" "1.557" "0.697" "1.569" "1.184" "1.479" "0.619" "1.473" "6.171" "9.2" "8.8" "14.4" "6.4" "14.5" "10.9" "13.7" "5.7" "13.6" "57.0" "" "" "" "" "" "" "" "" "" "" "5.5" "4.6" "8.0" "3.0" "6.7" "5.6" "6.3" "2.6" "7.4" "57.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8869464350434744721" "False" "High" "IsMasterProtein" "O95372" "Acyl-protein thioesterase 2 OS=Homo sapiens OX=9606 GN=LYPLA2 PE=1 SV=1" "0.003" "False" "2.871" "3" "1" "4" "1" "231" "24.7" "7.23" "9.29" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02230" "11313" "ENSG00000011009" "LYPLA2" "hsa:11313; O95372; Q7Z4Z2" "" "L1CAM interactions" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8617908927917494365" "False" "High" "IsMasterProtein" "O14639" "Actin-binding LIM protein 1 OS=Homo sapiens OX=9606 GN=ABLIM1 PE=1 SV=3" "0.003" "False" "2.865" "1" "1" "1" "1" "778" "87.6" "8.59" "2.56" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf02209, Pf16182" "3983" "ENSG00000099204" "ABLIM1" "A6NI16; A6NJ06; A8MXA9; B3KVH2; hsa:3983; O14639; Q15039; Q5JVV1; Q5JVV2; Q5T6N2; Q5T6N3; Q5T6N5; Q68CQ9; Q9BUP1" "Male infertility" "DCC mediated attractive signaling" "2" "0" "1.068" "0.967" "1.036" "0.999" "1.004" "1.165" "0.974" "0.947" "0.748" "63.9" "68.3" "61.8" "66.2" "63.8" "64.1" "74.5" "62.3" "60.5" "47.8" "" "" "" "" "" "" "" "" "" "" "38.2" "35.5" "34.2" "31.1" "29.6" "32.8" "34.6" "27.9" "32.8" "47.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9173522146093415156" "False" "High" "IsMasterProtein" "Q9P0J7" "E3 ubiquitin-protein ligase KCMF1 OS=Homo sapiens OX=9606 GN=KCMF1 PE=1 SV=2" "0.003" "False" "2.864" "2" "1" "1" "1" "381" "41.9" "5.66" "2.39" "1" "cell-cell signaling" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00569, Pf05605" "56888" "ENSG00000176407" "KCMF1" "Q4ZG04; Q53SC7; Q9BWK2; Q9H8P5; Q9P0J7; Q9UFE8" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8787657634019778386" "False" "High" "IsMasterProtein" "Q2TAA2" "Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Homo sapiens OX=9606 GN=IAH1 PE=1 SV=1" "0.003" "False" "2.864" "3" "1" "1" "1" "248" "27.6" "5.30" "2.90" "1" "other metabolic processes" "" "other molecular function" "Pf00657" "285148" "ENSG00000134330" "IAH1" "B4DMV3; hsa:285148; Q2TAA2" "" "" "0" "0" "1.081" "0.954" "1.100" "0.914" "0.911" "1.086" "1.199" "0.896" "0.549" "78.2" "84.6" "74.6" "86.1" "71.5" "71.3" "85.0" "93.8" "70.1" "42.9" "" "" "" "" "" "" "" "" "" "" "46.8" "43.9" "41.3" "40.4" "33.1" "36.5" "39.5" "42.1" "38.0" "42.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5384337703464320291" "False" "High" "IsMasterProtein" "Q16822" "Phosphoenolpyruvate carboxykinase [GTP], mitochondrial OS=Homo sapiens OX=9606 GN=PCK2 PE=1 SV=4" "0.003" "False" "2.863" "2" "1" "1" "1" "640" "70.7" "7.62" "2.00" "1" "other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00821, Pf17297" "5106" "ENSG00000100889; ENSG00000285241" "PCK2" "B4DW73; hsa:5106; O43253; Q16822; Q86U01; Q9BV62" "Adipogenesis; Transcription factor regulation in adipogenesis; PPAR signaling pathway; PI3K-Akt signaling pathway; Krebs cycle disorders; DNA damage response (only ATM dependent)" "Gluconeogenesis" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3116404034014267296" "False" "High" "IsMasterProtein" "Q5U5Q3" "RNA-binding E3 ubiquitin-protein ligase MEX3C OS=Homo sapiens OX=9606 GN=MEX3C PE=1 SV=3" "0.003" "False" "2.860" "1" "1" "1" "1" "659" "69.3" "5.00" "2.15" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf13920" "51320" "ENSG00000176624" "MEX3C" "A1L022; Q5U5Q3; Q9NZE3" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5201863361074030149" "False" "High" "IsMasterProtein" "O95071" "E3 ubiquitin-protein ligase UBR5 OS=Homo sapiens OX=9606 GN=UBR5 PE=1 SV=2" "0.003" "False" "2.852" "0" "1" "1" "1" "2799" "309.2" "5.85" "1.91" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00632, Pf00658, Pf11547" "51366" "ENSG00000104517" "UBR5" "B2RP24; hsa:51366; J3KMW7; O94970; O95071; Q9NPL3" "Mesodermal commitment pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6385362476021457625" "False" "High" "IsMasterProtein" "B3KNS4" "Endogenous retrovirus group K3 member 1 OS=Homo sapiens OX=9606 GN=ERVK3-1 PE=1 SV=1" "0.003" "False" "2.848" "13" "1" "1" "1" "109" "11.6" "7.78" "0.00" "1" "" "" "" "Pf15695" "" "ENSG00000142396" "ERVK3-1" "B3KNS4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4497117085705849008" "False" "High" "IsMasterProtein" "Q9UHY1" "Nuclear receptor-binding protein OS=Homo sapiens OX=9606 GN=NRBP1 PE=1 SV=1" "0.003" "False" "2.845" "2" "1" "1" "1" "535" "59.8" "5.08" "2.26" "1" "transport" "other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf07714" "29959" "ENSG00000115216" "NRBP1" "B3KV40; D6W558; hsa:29959; Q53FZ5; Q96SU3; Q9UHY1" "" "Nuclear Receptor transcription pathway" "1" "0" "0.945" "1.046" "1.086" "0.822" "1.068" "0.842" "1.615" "0.946" "0.838" "26.4" "25.0" "27.7" "28.7" "21.7" "28.2" "22.3" "42.7" "25.0" "22.2" "" "" "" "" "" "" "" "" "" "" "15.8" "13.0" "15.3" "13.5" "10.1" "14.5" "10.4" "19.2" "13.6" "22.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5049084120360688973" "False" "High" "IsMasterProtein" "Q6PL24" "Protein TMED8 OS=Homo sapiens OX=9606 GN=TMED8 PE=1 SV=1" "0.003" "False" "2.840" "5" "2" "2" "2" "325" "35.7" "4.74" "2.06" "2" "" "" "" "Pf13897" "283578" "ENSG00000100580" "TMED8" "B3KTI6; hsa:283578; Q3MJB0; Q6PL24; Q9P1V9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4223527727478599420" "False" "High" "IsMasterProtein" "Q9UBF8" "Phosphatidylinositol 4-kinase beta OS=Homo sapiens OX=9606 GN=PI4KB PE=1 SV=1" "0.003" "False" "2.840" "1" "1" "1" "1" "816" "91.3" "6.25" "2.08" "1" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00454, Pf21245" "5298" "ENSG00000143393" "PI4KB" "B4DGI2; hsa:5298; O15096; P78405; Q5VWB9; Q5VWC0; Q5VWC1; Q9BWR6; Q9UBF8" "" "Synthesis of PIPs at the Golgi membrane" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2364171353668644168" "False" "High" "IsMasterProtein" "Q00653" "Nuclear factor NF-kappa-B p100 subunit OS=Homo sapiens OX=9606 GN=NFKB2 PE=1 SV=4" "0.003" "False" "2.834" "1" "1" "1" "1" "900" "96.7" "6.25" "2.62" "1" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00023, Pf00531, Pf00554, Pf16179" "4791" "ENSG00000077150" "NFKB2" "A8K9D9; D3DR83; hsa:4791; Q00653; Q04860; Q9BU75; Q9H471; Q9H472" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Thymic stromal lymphopoietin (TSLP) signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; ApoE and miR-146 in inflammation and atherosclerosis; Ebola virus infection in host; Breast cancer pathway; Acute viral myocarditis; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; FGF23 signaling in hypophosphatemic rickets and related disorders; Mitochondrial immune response to SARS-CoV-2; Neuroinflammation and glutamatergic signaling; Network map of SARS-CoV-2 signaling pathway; Inclusion body myositis; GDNF signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; Interleukin-1 processing; SUMOylation of immune response proteins; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "43" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8582316469479536789" "False" "High" "IsMasterProtein" "Q92567" "Protein FAM168A OS=Homo sapiens OX=9606 GN=FAM168A PE=1 SV=2" "0.003" "False" "2.832" "3" "1" "2" "1" "244" "26.2" "8.98" "5.38" "1" "other biological processes" "" "" "Pf14944" "23201" "ENSG00000054965" "FAM168A" "A2ICY2; A2ID81; hsa:23201; Q86UG2; Q92567" "" "" "0" "0" "1.005" "0.863" "0.736" "0.963" "1.084" "0.856" "1.039" "0.892" "0.586" "198.3" "199.2" "171.1" "145.9" "190.9" "214.9" "169.6" "205.9" "176.9" "116.1" "" "" "" "" "" "" "" "" "" "" "118.7" "103.5" "94.7" "68.5" "88.5" "110.0" "78.9" "92.5" "96.0" "116.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4801504579459921117" "False" "High" "IsMasterProtein" "Q8IXQ3" "Uncharacterized protein C9orf40 OS=Homo sapiens OX=9606 GN=C9orf40 PE=1 SV=1" "0.003" "False" "2.830" "5" "1" "1" "1" "194" "21.1" "5.01" "2.19" "1" "" "" "" "Pf15017" "55071" "ENSG00000135045" "C9orf40" "hsa:55071; Q8IXQ3; Q9NWD3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6076277421311932307" "False" "High" "IsMasterProtein" "O43930" "Putative serine/threonine-protein kinase PRKY OS=Homo sapiens OX=9606 GN=PRKY PE=5 SV=1" "0.003" "False" "2.829" "3" "1" "1" "1" "277" "31.7" "6.96" "1.99" "1" "protein metabolism;other metabolic processes" "" "kinase activity;other molecular function" "Pf00069" "" "" "PRKY" "O15348; O15349; O43930" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1629654953317171872" "False" "High" "IsMasterProtein" "Q68CP9" "AT-rich interactive domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ARID2 PE=1 SV=2" "0.003" "False" "2.818" "0" "1" "1" "1" "1835" "197.3" "7.42" "2.22" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01388, Pf02257" "196528" "ENSG00000189079" "ARID2" "Q15KG9; Q5EB51; Q645I3; Q68CP9; Q6ZRY5; Q7Z3I5; Q86T28; Q96SJ6; Q9HCL5" "" "RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8390687985957490189" "False" "High" "IsMasterProtein" "Q5VTR2" "E3 ubiquitin-protein ligase BRE1A OS=Homo sapiens OX=9606 GN=RNF20 PE=1 SV=2" "0.003" "False" "2.807" "1" "1" "1" "1" "975" "113.6" "5.94" "2.89" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097" "56254" "ENSG00000155827" "RNF20" "A7MCT5; hsa:56254; Q2TB34; Q5VTR2; Q69YL5; Q6P527; Q8N3J4; Q96JD3; Q9H9Y7; Q9HA51; Q9NUR4; Q9NWQ3; Q9NX83" "ATM signaling in development and disease" "E3 ubiquitin ligases ubiquitinate target proteins; RHOBTB1 GTPase cycle" "3" "0" "1.425" "1.510" "1.432" "1.496" "1.240" "1.278" "0.781" "1.812" "4.028" "33.0" "47.1" "49.9" "47.3" "49.4" "41.0" "42.2" "25.8" "59.9" "133.0" "" "" "" "" "" "" "" "" "" "" "19.8" "24.5" "27.6" "22.2" "22.9" "21.0" "19.6" "11.6" "32.5" "133.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "577500699946211837" "False" "High" "IsMasterProtein" "Q8NFQ8" "Torsin-1A-interacting protein 2 OS=Homo sapiens OX=9606 GN=TOR1AIP2 PE=1 SV=1" "0.003" "False" "2.807" "2" "1" "1" "1" "470" "51.2" "4.96" "2.10" "1" "cell organization and biogenesis;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf05609, Pf20443" "163590" "ENSG00000169905" "TOR1AIP2" "hsa:163590; Q8NFQ8" "" "" "0" "0" "1.158" "1.079" "0.929" "1.109" "1.334" "1.256" "1.457" "1.097" "0.693" "27.0" "31.2" "29.1" "25.1" "29.9" "36.0" "33.9" "39.3" "29.6" "18.7" "" "" "" "" "" "" "" "" "" "" "16.2" "16.2" "16.1" "11.8" "13.9" "18.4" "15.8" "17.7" "16.1" "18.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6591516084365101626" "False" "High" "IsMasterProtein" "Q9H5X1" "Cytosolic iron-sulfur assembly component 2A OS=Homo sapiens OX=9606 GN=CIAO2A PE=1 SV=1" "0.003" "False" "2.806" "7" "1" "1" "1" "160" "18.3" "4.88" "2.95" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01883" "84191" "ENSG00000166797" "CIAO2A" "A6NKS1; B2R5F8; B7Z8Z5; hsa:84191; Q9H5X1" "2q11.2 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5516289566189376071" "False" "High" "IsMasterProtein" "Q13084" "Large ribosomal subunit protein bL28m OS=Homo sapiens OX=9606 GN=MRPL28 PE=1 SV=4" "0.003" "False" "2.805" "5" "1" "1" "1" "256" "30.1" "8.29" "0.00" "1" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "other molecular function" "Pf00830" "10573" "ENSG00000086504" "MRPL28" "B2RCM4; D3DU46; hsa:10573; Q13084; Q4TT39; Q96S26; Q9BQD8; Q9BR04" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1992212741193317441" "False" "High" "IsMasterProtein" "Q13247" "Serine/arginine-rich splicing factor 6 OS=Homo sapiens OX=9606 GN=SRSF6 PE=1 SV=2" "0.003" "False" "2.804" "3" "1" "1" "1" "344" "39.6" "11.43" "2.81" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076" "6431" "ENSG00000124193" "SRSF6" "B7Z6J3; E1P5W6; hsa:6431; Q13244; Q13245; Q13247; Q96J06; Q9UJB8; Q9Y3N7" "mRNA processing" "RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1899835700088576048" "False" "High" "IsMasterProtein" "O14656" "Torsin-1A OS=Homo sapiens OX=9606 GN=TOR1A PE=1 SV=1" "0.003" "False" "2.796" "3" "1" "1" "1" "332" "37.8" "6.99" "2.43" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf06309, Pf21376" "1861" "ENSG00000136827" "TOR1A" "B2RB58; hsa:1861; O14656; Q53Y64; Q96CA0" "" "Cargo recognition for clathrin-mediated endocytosis" "1" "0" "0.973" "0.934" "1.245" "1.310" "1.075" "0.843" "1.308" "0.798" "0.911" "27.2" "26.4" "25.4" "33.8" "35.6" "29.2" "22.9" "35.5" "21.7" "24.7" "" "" "" "" "" "" "" "" "" "" "16.3" "13.7" "14.0" "15.9" "16.5" "14.9" "10.6" "15.9" "11.8" "24.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8488452650529328010" "False" "High" "IsMasterProtein" "Q5VIR6" "Vacuolar protein sorting-associated protein 53 homolog OS=Homo sapiens OX=9606 GN=VPS53 PE=1 SV=2" "0.003" "False" "2.794" "1" "1" "1" "1" "832" "94.3" "6.70" "2.92" "1" "transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04100, Pf16854" "55275" "ENSG00000141252; ENSG00000283883" "VPS53" "A8K2S8; B3FH42; hsa:55275; Q5VIR6; Q8WYW3; Q9BRR2; Q9BY02; Q9NV25" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "1.004" "0.830" "1.493" "1.378" "1.156" "0.901" "0.188" "0.757" "5.200" "17.8" "17.9" "14.8" "26.6" "24.5" "20.6" "16.0" "3.3" "13.5" "92.6" "" "" "" "" "" "" "" "" "" "" "10.7" "9.3" "8.2" "12.5" "11.4" "10.5" "7.5" "1.5" "7.3" "92.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4696215040566855502" "False" "High" "IsMasterProtein" "Q9H446" "RWD domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RWDD1 PE=1 SV=1" "0.003" "False" "2.790" "3" "1" "1" "1" "243" "27.9" "4.20" "2.85" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other cell component" "" "Pf05773, Pf16543" "51389" "ENSG00000111832" "RWDD1" "A8K3W2; A8MT24; hsa:51389; Q9H446; Q9Y313; Q9Y6B3" "" "Protein hydroxylation" "1" "0" "1.168" "1.369" "1.229" "1.251" "1.181" "1.223" "1.229" "1.104" "1.069" "86.8" "101.4" "118.9" "106.7" "108.6" "102.6" "106.2" "106.7" "95.9" "92.8" "" "" "" "" "" "" "" "" "" "" "52.0" "52.7" "65.8" "50.1" "50.4" "52.5" "49.4" "47.9" "52.0" "92.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6983483800967602038" "False" "High" "IsMasterProtein" "Q9NVM9" "Integrator complex subunit 13 OS=Homo sapiens OX=9606 GN=INTS13 PE=1 SV=2" "0.003" "False" "2.790" "1" "1" "2" "1" "706" "80.2" "6.70" "5.42" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf10221" "55726" "ENSG00000064102" "INTS13" "B4DNK1; hsa:55726; Q86WE2; Q96HM2; Q9BTX2; Q9NTB6; Q9NVM5; Q9NVM9" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4453552053953244697" "False" "High" "IsMasterProtein" "P19634" "Sodium/hydrogen exchanger 1 OS=Homo sapiens OX=9606 GN=SLC9A1 PE=1 SV=2" "0.003" "False" "2.780" "3" "1" "1" "1" "815" "90.7" "7.21" "2.11" "1" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;nucleus;other cell component" "transporter activity;other molecular function" "Pf00999, Pf16644" "6548" "ENSG00000090020" "SLC9A1" "B1ALD6; D3DPL4; hsa:6548; P19634; Q96EM2" "Osteoclast signaling; G protein signaling pathways; Gastrin signaling pathway; Opioid receptor pathways; Regulation of actin cytoskeleton" "Hyaluronan uptake and degradation; Sodium/Proton exchangers" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "High" "High" "Not Found" "High" "Not Found" "High" "Not Found" "Not Found" "1" "" "-1716870644817082742" "False" "High" "IsMasterProtein" "Q15751" "Probable E3 ubiquitin-protein ligase HERC1 OS=Homo sapiens OX=9606 GN=HERC1 PE=1 SV=2" "0.003" "False" "2.775" "0" "1" "1" "1" "4861" "531.9" "6.04" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf00415, Pf00622, Pf00632" "8925" "ENSG00000103657" "HERC1" "hsa:8925; Q15751; Q8IW65" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "High" "High" "Not Found" "High" "High" "High" "High" "High" "1" "" "-383335111069342987" "False" "High" "IsMasterProtein" "Q6PD74" "Alpha- and gamma-adaptin-binding protein p34 OS=Homo sapiens OX=9606 GN=AAGAB PE=1 SV=1" "0.003" "False" "2.774" "3" "1" "1" "1" "315" "34.6" "4.64" "2.32" "1" "transport" "cytosol;nucleus;other cell component" "" "Pf10199" "79719" "ENSG00000103591" "AAGAB" "B4DG44; hsa:79719; Q6FI86; Q6PD74; Q7Z5X9; Q9H0P1; Q9HAK0" "" "" "0" "0" "1.143" "1.154" "0.952" "1.140" "1.071" "1.044" "0.601" "1.205" "5.228" "52.6" "60.1" "60.7" "50.1" "59.9" "56.3" "54.9" "31.6" "63.3" "274.9" "" "" "" "" "" "" "" "" "" "" "31.5" "31.2" "33.6" "23.5" "27.8" "28.8" "25.5" "14.2" "34.4" "274.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7997158032231502372" "False" "High" "IsMasterProtein" "Q9Y6D9" "Mitotic spindle assembly checkpoint protein MAD1 OS=Homo sapiens OX=9606 GN=MAD1L1 PE=1 SV=2" "0.003" "False" "2.768" "1" "1" "1" "1" "718" "83.0" "5.92" "2.53" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05557" "8379" "ENSG00000002822" "MAD1L1" "B3KR41; hsa:8379; Q13312; Q75MI0; Q86UM4; Q9UNH0; Q9Y6D9" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; Pleural mesothelioma; CCL18 signaling pathway" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "10" "0" "0.743" "0.953" "0.884" "1.056" "1.019" "0.678" "0.421" "0.841" "4.492" "35.0" "26.0" "33.4" "31.0" "37.0" "35.7" "23.7" "14.7" "29.5" "157.3" "" "" "" "" "" "" "" "" "" "" "21.0" "13.5" "18.5" "14.5" "17.1" "18.3" "11.0" "6.6" "16.0" "157.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3163667791895929702" "False" "High" "IsMasterProtein" "Q63ZY3" "KN motif and ankyrin repeat domain-containing protein 2 OS=Homo sapiens OX=9606 GN=KANK2 PE=1 SV=1" "0.003" "False" "2.765" "2" "1" "1" "1" "851" "91.1" "5.63" "0.00" "1" "cell organization and biogenesis;developmental processes;other biological processes" "mitochondrion;other cell component" "" "Pf12075, Pf12796" "25959" "ENSG00000197256" "KANK2" "B0I1P4; hsa:25959; Q3KQZ3; Q63ZY3; Q6GUF5; Q9H8S4; Q9NUP0; Q9P210" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "High" "High" "High" "1" "" "-8265724560765906942" "False" "High" "IsMasterProtein" "Q9BVP2" "Guanine nucleotide-binding protein-like 3 OS=Homo sapiens OX=9606 GN=GNL3 PE=1 SV=2" "0.003" "False" "2.764" "1" "1" "1" "1" "549" "62.0" "9.16" "2.49" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01926, Pf08701" "26354" "ENSG00000163938" "GNL3" "B2RDC1; hsa:26354; Q5PU80; Q96SV6; Q96SV7; Q9BVP2; Q9UJY0" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8213530415283437885" "False" "High" "IsMasterProtein" "Q9Y2R0" "Cytochrome c oxidase assembly factor 3 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=COA3 PE=1 SV=1" "0.003" "False" "2.763" "8" "1" "1" "1" "106" "11.7" "9.60" "2.79" "1" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "" "Pf09813" "28958" "ENSG00000183978" "COA3" "A8K498; hsa:28958; Q9Y2R0" "Mitochondrial complex IV assembly; Arsenic metabolism and reactive oxygen species generation" "" "2" "0" "1.098" "1.365" "1.066" "1.140" "1.502" "1.491" "1.373" "1.158" "0.790" "27.3" "30.0" "37.3" "29.1" "31.2" "41.1" "40.8" "37.5" "31.7" "21.6" "" "" "" "" "" "" "" "" "" "" "16.4" "15.6" "20.7" "13.7" "14.4" "21.0" "19.0" "16.8" "17.2" "21.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9004188409903141881" "False" "High" "IsMasterProtein" "P52758" "2-iminobutanoate/2-iminopropanoate deaminase OS=Homo sapiens OX=9606 GN=RIDA PE=1 SV=1" "0.003" "False" "2.762" "12" "1" "1" "1" "137" "14.5" "8.68" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01042" "10247" "ENSG00000132541" "RIDA" "hsa:10247; P52758; Q6FHU9; Q6IBG0" "" "Threonine catabolism" "1" "0" "1.022" "0.923" "1.087" "0.915" "0.971" "0.944" "1.063" "1.081" "0.668" "180.9" "184.8" "166.9" "196.5" "165.6" "175.6" "170.7" "192.3" "195.6" "120.8" "" "" "" "" "" "" "" "" "" "" "108.2" "96.0" "92.4" "92.3" "76.7" "89.9" "79.4" "86.3" "106.1" "120.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4502838028789951010" "False" "High" "IsMasterProtein" "P51397" "Death-associated protein 1 OS=Homo sapiens OX=9606 GN=DAP PE=1 SV=3" "0.003" "False" "2.757" "8" "1" "12" "1" "102" "11.2" "9.32" "13.42" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "" "other molecular function" "Pf15228" "1611" "ENSG00000112977" "DAP" "hsa:1611; P51397; Q6FGC3; Q9BUC9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5965687288212214297" "False" "High" "IsMasterProtein" "Q7L2H7" "Eukaryotic translation initiation factor 3 subunit M OS=Homo sapiens OX=9606 GN=EIF3M PE=1 SV=1" "0.003" "False" "2.756" "2" "1" "1" "1" "374" "42.5" "5.63" "3.35" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01399, Pf18005" "10480" "ENSG00000149100" "EIF3M" "A8K7X4; B4E2Q4; hsa:10480; O60735; Q2F836; Q53HL6; Q7L2H7; Q9BXW1" "" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "6" "0" "0.916" "1.235" "0.932" "1.078" "1.120" "0.786" "0.633" "1.033" "4.764" "59.8" "54.8" "73.9" "55.8" "64.5" "67.0" "47.0" "37.9" "61.8" "285.1" "" "" "" "" "" "" "" "" "" "" "35.8" "28.5" "40.9" "26.2" "29.9" "34.3" "21.9" "17.0" "33.5" "285.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5589324606331654897" "False" "High" "IsMasterProtein" "Q6P161" "Large ribosomal subunit protein mL54 OS=Homo sapiens OX=9606 GN=MRPL54 PE=1 SV=1" "0.003" "False" "2.754" "7" "1" "1" "1" "138" "15.8" "9.60" "2.28" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf08561" "116541" "ENSG00000183617" "MRPL54" "hsa:116541; Q6P161" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.774" "0.785" "1.102" "0.820" "0.977" "0.862" "0.843" "1.016" "0.622" "91.1" "70.5" "71.5" "100.4" "74.7" "89.0" "78.5" "76.8" "92.6" "56.6" "" "" "" "" "" "" "" "" "" "" "54.5" "36.6" "39.6" "47.1" "34.6" "45.6" "36.5" "34.5" "50.2" "56.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1428811385271777844" "False" "High" "IsMasterProtein" "Q9H488" "GDP-fucose protein O-fucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POFUT1 PE=1 SV=1" "0.003" "False" "2.744" "3" "1" "1" "1" "388" "43.9" "8.53" "2.43" "1" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf10250" "23509" "ENSG00000101346" "POFUT1" "A8K4R8; E1P5M4; hsa:23509; Q14685; Q5W185; Q9BW76; Q9H488" "" "Pre-NOTCH Processing in the Endoplasmic Reticulum" "1" "0" "1.235" "0.858" "0.948" "1.010" "0.990" "0.887" "1.025" "0.816" "0.587" "44.1" "54.4" "37.8" "41.8" "44.5" "43.6" "39.1" "45.2" "36.0" "25.9" "" "" "" "" "" "" "" "" "" "" "26.4" "28.3" "20.9" "19.6" "20.6" "22.3" "18.2" "20.3" "19.5" "25.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7436482478148807515" "False" "High" "IsMasterProtein" "Q86TB9" "Protein PAT1 homolog 1 OS=Homo sapiens OX=9606 GN=PATL1 PE=1 SV=2" "0.003" "False" "2.744" "1" "1" "1" "1" "770" "86.8" "6.67" "1.73" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf09770" "219988" "ENSG00000166889" "PATL1" "B3KXT9; hsa:219988; Q2TA86; Q6P166; Q86TB9; Q8N9M6; Q8NI63" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "0.959" "0.955" "1.419" "1.030" "1.202" "1.054" "1.222" "1.037" "4.596" "23.5" "22.6" "22.5" "33.4" "24.2" "28.3" "24.8" "28.8" "24.4" "108.2" "" "" "" "" "" "" "" "" "" "" "14.1" "11.7" "12.4" "15.7" "11.2" "14.5" "11.5" "12.9" "13.2" "108.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1508959840554036408" "False" "High" "IsMasterProtein" "Q969V6" "Myocardin-related transcription factor A OS=Homo sapiens OX=9606 GN=MRTFA PE=1 SV=1" "0.003" "False" "2.741" "1" "1" "1" "1" "931" "98.9" "5.86" "2.63" "1" "cell organization and biogenesis;stress response;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02037, Pf02755" "57591" "ENSG00000196588" "MRTFA" "hsa:57591; Q8TCL1; Q969V6; Q96SC5; Q96SC6; Q9P2B0" "" "RHO GTPases Activate Formins; SUMOylation of transcription cofactors" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9201189030336339183" "False" "High" "IsMasterProtein" "P62875" "DNA-directed RNA polymerases I, II, and III subunit RPABC5 OS=Homo sapiens OX=9606 GN=POLR2L PE=1 SV=1" "0.003" "False" "2.739" "13" "1" "2" "1" "67" "7.6" "7.77" "4.18" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01194" "5441" "ENSG00000177700" "POLR2L" "hsa:5441; P52436; P62875; Q6FHX3" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "56" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5229500280398030060" "False" "High" "IsMasterProtein" "Q9Y2E5" "Epididymis-specific alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2B2 PE=1 SV=4" "0.003" "False" "2.738" "1" "1" "1" "1" "1009" "113.9" "7.24" "2.32" "1" "other metabolic processes" "other cytoplasmic organelle" "other molecular function" "Pf01074, Pf07748, Pf09261" "23324" "ENSG00000013288" "MAN2B2" "hsa:23324; Q66MP2; Q86T67; Q9Y2E5" "" "Lysosomal oligosaccharide catabolism" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7472508916157269106" "False" "High" "IsMasterProtein" "Q9H9P8" "L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=L2HGDH PE=1 SV=3" "0.003" "False" "2.734" "2" "1" "2" "1" "463" "50.3" "8.15" "2.23" "1" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf01266" "79944" "ENSG00000087299" "L2HGDH" "hsa:79944; Q9BRR1; Q9H9P8" "Cerebral organic acidurias, including diseases" "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" "2" "0" "1.316" "1.178" "1.444" "1.447" "1.173" "1.479" "1.302" "1.247" "3.027" "94.5" "124.3" "111.3" "136.4" "136.7" "110.8" "139.7" "123.0" "117.8" "286.0" "" "" "" "" "" "" "" "" "" "" "56.5" "64.6" "61.6" "64.0" "63.4" "56.7" "65.0" "55.2" "63.9" "286.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6748145975597498784" "False" "High" "IsMasterProtein" "O75920" "Small EDRK-rich factor 1 OS=Homo sapiens OX=9606 GN=SERF1B PE=1 SV=1" "0.003" "False" "2.725" "8" "1" "1" "1" "110" "12.3" "9.76" "2.49" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04419" "728492; 8293" "ENSG00000172058; ENSG00000205572; ENSG00000275581; ENSG00000277429; ENSG00000278839" "SERF1A; SERF1B" "B7ZKM2; hsa:728492; hsa:8293; O75919; O75920; Q52LK5" "" "" "0" "0" "1.016" "1.154" "1.034" "0.915" "1.128" "1.289" "0.943" "1.015" "0.938" "37.8" "38.4" "43.6" "39.1" "34.6" "42.7" "48.7" "35.7" "38.4" "35.5" "" "" "" "" "" "" "" "" "" "" "22.6" "20.0" "24.2" "18.4" "16.0" "21.8" "22.7" "16.0" "20.8" "35.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-173769377935829106" "False" "High" "IsMasterProtein" "Cont_P15497" "Apolipoprotein A-I OS=Bos taurus OX=9913 GN=APOA1 PE=1 SV=3" "0.003" "True" "2.708" "4" "1" "1" "1" "265" "30.3" "5.97" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function" "Pf01442" "281631" "ENSBIXG00000010441; ENSBIXG00005004093; ENSBTAG00000002258" "APOA1" "A0A4W2DWW2; A5D7M9; bta:281631; P15497; Q3SZD9; V6F9A2" "Statin pathway; Folate metabolism; Vitamin B12 metabolism; Selenium micronutrient network" "Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Chylomicron assembly; Chylomicron remodeling; HDL remodeling; Retinoid metabolism and transport; HDL clearance; HDL assembly; Heme signaling; Scavenging by Class B Receptors" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4822956659812595428" "False" "High" "IsMasterProtein" "P17706" "Tyrosine-protein phosphatase non-receptor type 2 OS=Homo sapiens OX=9606 GN=PTPN2 PE=1 SV=2" "0.003" "False" "2.707" "2" "1" "1" "1" "415" "48.4" "8.29" "2.27" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00102" "5771" "ENSG00000175354" "PTPN2" "A8K955; A8MXU3; hsa:5771; K7ENG3; P17706; Q96AU5; Q96HR2" "Immune response to tuberculosis; 5q35 copy number variation" "PKR-mediated signaling; Negative regulation of MET activity; Interleukin-37 signaling" "5" "0" "1.006" "1.199" "2.053" "1.344" "1.163" "1.349" "1.099" "1.288" "4.025" "20.1" "20.2" "24.1" "41.2" "27.0" "23.3" "27.1" "22.1" "25.8" "80.8" "" "" "" "" "" "" "" "" "" "" "12.0" "10.5" "13.3" "19.3" "12.5" "11.9" "12.6" "9.9" "14.0" "80.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "514790625548438605" "False" "High" "IsMasterProtein" "Q8WUX2" "Glutathione-specific gamma-glutamylcyclotransferase 2 OS=Homo sapiens OX=9606 GN=CHAC2 PE=1 SV=1" "0.003" "False" "2.702" "5" "1" "3" "1" "184" "20.9" "5.43" "4.10" "1" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf04752" "494143" "ENSG00000143942" "CHAC2" "hsa:494143; Q8WUX2; Q8WVI8" "" "Glutathione synthesis and recycling" "1" "0" "1.094" "1.508" "1.048" "1.026" "1.249" "1.182" "0.858" "1.235" "1.436" "56.2" "61.5" "84.8" "58.9" "57.7" "70.2" "66.4" "48.2" "69.4" "80.7" "" "" "" "" "" "" "" "" "" "" "33.6" "32.0" "46.9" "27.6" "26.7" "35.9" "30.9" "21.6" "37.7" "80.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4875234499947995187" "False" "High" "IsMasterProtein" "Q93100" "Phosphorylase b kinase regulatory subunit beta OS=Homo sapiens OX=9606 GN=PHKB PE=1 SV=3" "0.003" "False" "2.699" "1" "1" "1" "1" "1093" "124.8" "6.95" "2.26" "1" "other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00723, Pf19292" "5257" "ENSG00000102893" "PHKB" "hsa:5257; Q8N4T5; Q93100" "Glycogen synthesis and degradation" "Glycogen breakdown (glycogenolysis)" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4336688759083416299" "False" "High" "IsMasterProtein" "Q15813" "Tubulin-specific chaperone E OS=Homo sapiens OX=9606 GN=TBCE PE=1 SV=1" "0.003" "False" "2.696" "2" "1" "1" "1" "527" "59.3" "6.76" "1.81" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf14560" "6905" "ENSG00000284770" "TBCE" "A8K8C2; B7Z3P1; Q15813" "" "Post-chaperonin tubulin folding pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4939366548436887845" "False" "High" "IsMasterProtein" "Q7L0Y3" "tRNA methyltransferase 10 homolog C OS=Homo sapiens OX=9606 GN=TRMT10C PE=1 SV=2" "0.003" "False" "2.688" "2" "1" "1" "1" "403" "47.3" "9.36" "2.19" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01746" "54931" "ENSG00000174173" "TRMT10C" "hsa:54931; Q7L0Y3; Q9NRG5; Q9NX54; Q9Y596" "" "tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5258302069466510735" "False" "High" "IsMasterProtein" "P56279" "T-cell leukemia/lymphoma protein 1A OS=Homo sapiens OX=9606 GN=TCL1A PE=1 SV=1" "0.003" "False" "2.682" "6" "1" "6" "1" "114" "13.5" "5.11" "17.07" "1" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01840" "8115" "ENSG00000100721" "TCL1A" "hsa:8115; P56279; Q6IBK7" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "" "2" "0" "1.027" "0.993" "0.973" "0.891" "1.066" "0.957" "0.985" "0.929" "0.759" "831.8" "854.1" "826.3" "809.3" "741.3" "886.8" "795.9" "819.2" "773.1" "631.4" "" "" "" "" "" "" "" "" "" "" "497.8" "443.9" "457.6" "379.9" "343.6" "454.0" "370.1" "367.8" "419.4" "631.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "984760743341076196" "False" "High" "IsMasterProtein" "Q9Y547" "Intraflagellar transport protein 25 homolog OS=Homo sapiens OX=9606 GN=IFT25 PE=1 SV=1" "0.003" "False" "2.682" "8" "1" "1" "1" "144" "16.3" "5.03" "2.52" "1" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00754" "51668" "ENSG00000081870" "IFT25" "A6NG57; D3DQ45; hsa:51668; Q9Y547; Q9Y684" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); GDNF/RET signaling axis; Alstrom syndrome" "Intraflagellar transport" "6" "0" "0.564" "0.903" "1.501" "1.252" "1.070" "0.758" "0.908" "1.481" "0.966" "21.4" "12.0" "19.3" "32.1" "26.7" "22.8" "16.2" "19.4" "31.6" "20.6" "" "" "" "" "" "" "" "" "" "" "12.8" "6.3" "10.7" "15.0" "12.4" "11.7" "7.5" "8.7" "17.2" "20.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8026992804565503724" "False" "High" "IsMasterProtein" "Q13257" "Mitotic spindle assembly checkpoint protein MAD2A OS=Homo sapiens OX=9606 GN=MAD2L1 PE=1 SV=1" "0.003" "False" "2.674" "4" "1" "4" "1" "205" "23.5" "5.08" "8.18" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf02301" "4085" "ENSG00000164109" "MAD2L1" "hsa:4085; Q13257; Q53F56; Q548X9; Q6IRW7; Q8IZX3" "Regulation of sister chromatid separation at the metaphase-anaphase transition; Pleural mesothelioma" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "13" "0" "1.011" "1.197" "1.174" "1.138" "1.159" "1.127" "0.874" "1.013" "3.446" "125.5" "126.9" "150.2" "147.4" "142.8" "145.4" "141.5" "109.7" "127.2" "432.4" "" "" "" "" "" "" "" "" "" "" "75.1" "66.0" "83.2" "69.2" "66.2" "74.4" "65.8" "49.3" "69.0" "432.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2957461368778197343" "False" "High" "IsMasterProtein" "Q96I51" "RCC1-like G exchanging factor-like protein OS=Homo sapiens OX=9606 GN=RCC1L PE=1 SV=3" "0.003" "False" "2.673" "2" "1" "1" "1" "464" "49.9" "8.29" "3.63" "1" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00415, Pf13540" "81554" "ENSG00000274523" "RCC1L" "D3DXK0; F5GX55; F5H6C7; hsa:81554; Q548B1; Q8IW88; Q8N572; Q96I51; Q9H0G7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4122244859069195901" "False" "High" "IsMasterProtein" "Q9NVM6" "DnaJ homolog subfamily C member 17 OS=Homo sapiens OX=9606 GN=DNAJC17 PE=1 SV=1" "0.003" "False" "2.672" "4" "1" "1" "1" "304" "34.7" "8.53" "1.72" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00226" "55192" "ENSG00000104129" "DNAJC17" "hsa:55192; Q9NVM6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2299067407351932215" "False" "High" "IsMasterProtein" "P28907" "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 OS=Homo sapiens OX=9606 GN=CD38 PE=1 SV=2" "0.003" "False" "2.671" "3" "1" "1" "1" "300" "34.3" "7.66" "2.44" "1" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf02267" "952" "ENSG00000004468" "CD38" "hsa:952; O00121; O00122; P28907; Q96HY4" "NAD+ metabolism; NAD+ biosynthetic pathways; Cell-type dependent selectivity of CCK2R signaling; Airway smooth muscle cell contraction" "Nicotinate metabolism" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "67998593382130798" "False" "High" "IsMasterProtein" "O15131" "Importin subunit alpha-6 OS=Homo sapiens OX=9606 GN=KPNA5 PE=1 SV=3" "0.003" "False" "2.670" "1" "1" "1" "1" "539" "60.6" "5.12" "2.58" "1" "transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3841" "ENSG00000196911" "KPNA5" "B2RAI5; hsa:3841; O15131; Q86X23" "" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4846678346596657924" "False" "High" "IsMasterProtein" "Q7L775" "EPM2A-interacting protein 1 OS=Homo sapiens OX=9606 GN=EPM2AIP1 PE=1 SV=1" "0.003" "False" "2.666" "1" "1" "1" "1" "607" "70.3" "6.11" "2.93" "1" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf18658" "9852" "ENSG00000178567" "EPM2AIP1" "hsa:9852; O94866; Q7L775; Q9H3L3" "" "" "0" "0" "1.184" "1.148" "0.996" "1.581" "1.302" "1.229" "1.029" "1.248" "1.929" "70.7" "83.6" "81.1" "70.4" "111.7" "92.0" "86.8" "72.7" "88.2" "136.3" "" "" "" "" "" "" "" "" "" "" "42.3" "43.5" "44.9" "33.1" "51.8" "47.1" "40.4" "32.7" "47.8" "136.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1314787517679089989" "False" "High" "IsMasterProtein" "Q8WUX9" "Charged multivesicular body protein 7 OS=Homo sapiens OX=9606 GN=CHMP7 PE=1 SV=1" "0.003" "False" "2.666" "2" "1" "1" "1" "453" "50.9" "5.35" "2.41" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf03357" "91782" "ENSG00000147457" "CHMP7" "B2RDT3; B4DKJ6; D3DSS1; hsa:91782; Q8NDM1; Q8WUX9; Q9BT50" "" "Late endosomal microautophagy; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5951829502980748262" "False" "High" "IsMasterProtein" "Q92989" "Polyribonucleotide 5'-hydroxyl-kinase Clp1 OS=Homo sapiens OX=9606 GN=CLP1 PE=1 SV=1" "0.003" "False" "2.665" "2" "1" "1" "1" "425" "47.6" "6.62" "2.58" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf06807, Pf16573, Pf16575" "10978" "ENSG00000172409" "CLP1" "B2R7J6; B4DTI8; hsa:10978; Q92989" "mRNA processing" "tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "6" "0" "1.051" "0.928" "1.112" "0.969" "1.171" "0.947" "1.182" "1.345" "3.793" "52.5" "55.2" "48.7" "58.5" "50.9" "61.5" "49.7" "62.1" "70.7" "199.3" "" "" "" "" "" "" "" "" "" "" "31.4" "28.7" "27.0" "27.4" "23.6" "31.5" "23.1" "27.9" "38.3" "199.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5558995711693310036" "False" "High" "IsMasterProtein" "Q9BWW4" "Single-stranded DNA-binding protein 3 OS=Homo sapiens OX=9606 GN=SSBP3 PE=1 SV=1" "0.003" "False" "2.664" "3" "1" "2" "1" "388" "40.4" "6.90" "4.69" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04503" "23648" "ENSG00000157216" "SSBP3" "A8K0A9; hsa:23648; Q5T860; Q5T861; Q9BTM0; Q9BWW3; Q9BWW4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3878380865412542485" "False" "High" "IsMasterProtein" "Q96G01" "Protein bicaudal D homolog 1 OS=Homo sapiens OX=9606 GN=BICD1 PE=1 SV=3" "0.003" "False" "2.663" "1" "1" "1" "1" "975" "110.7" "5.81" "0.00" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf09730" "636" "ENSG00000151746" "BICD1" "A8K2C3; F8W113; hsa:636; O43892; O43893; Q96G01" "" "COPI-independent Golgi-to-ER retrograde traffic" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-512652790618625432" "False" "High" "IsMasterProtein" "P40259" "B-cell antigen receptor complex-associated protein beta chain OS=Homo sapiens OX=9606 GN=CD79B PE=1 SV=1" "0.003" "False" "2.657" "5" "1" "1" "1" "229" "26.0" "5.92" "2.96" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf07686" "974" "ENSG00000007312" "CD79B" "hsa:974; P40259; Q53FS2; Q9BU06" "B cell receptor signaling pathway" "CD22 mediated BCR regulation; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "4" "0" "1.317" "1.349" "1.549" "1.362" "1.060" "1.385" "1.554" "1.995" "1.063" "75.5" "99.4" "101.8" "116.9" "102.8" "80.0" "104.5" "117.3" "150.5" "80.2" "" "" "" "" "" "" "" "" "" "" "45.2" "51.6" "56.4" "54.9" "47.6" "40.9" "48.6" "52.6" "81.7" "80.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4925331307854051957" "False" "High" "IsMasterProtein" "Q14739" "Delta(14)-sterol reductase LBR OS=Homo sapiens OX=9606 GN=LBR PE=1 SV=2" "0.003" "False" "2.653" "1" "1" "2" "1" "615" "70.7" "9.36" "5.42" "1" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01222, Pf09465" "3930" "ENSG00000143815" "LBR" "B2R5P3; hsa:3930; Q14739; Q14740; Q53GU7; Q59FE6" "Gastric cancer network 2; Envelope proteins and their potential roles in EDMD physiopathology; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "RHOC GTPase cycle; RHOA GTPase cycle; RHOD GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Regulation of MECP2 expression and activity; Initiation of Nuclear Envelope (NE) Reformation; Cholesterol biosynthesis" "18" "0" "0.959" "1.048" "0.945" "1.154" "0.808" "1.057" "0.878" "0.955" "1.641" "95.8" "91.8" "100.4" "90.5" "110.5" "77.4" "101.3" "84.1" "91.5" "157.1" "" "" "" "" "" "" "" "" "" "" "57.3" "47.7" "55.6" "42.5" "51.2" "39.6" "47.1" "37.8" "49.6" "157.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5234927014907967079" "False" "High" "IsMasterProtein" "Q9H0S4" "Probable ATP-dependent RNA helicase DDX47 OS=Homo sapiens OX=9606 GN=DDX47 PE=1 SV=1" "0.003" "False" "2.650" "2" "1" "1" "1" "455" "50.6" "9.10" "2.50" "1" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "nucleus" "other molecular function" "Pf00270, Pf00271" "51202" "ENSG00000213782" "DDX47" "B3KXP4; G5E955; hsa:51202; Q96GM0; Q96NV8; Q9H0S4; Q9UI98" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8200753479416328933" "False" "High" "IsMasterProtein" "Q8NF50" "Dedicator of cytokinesis protein 8 OS=Homo sapiens OX=9606 GN=DOCK8 PE=1 SV=3" "0.003" "False" "2.641" "0" "1" "1" "1" "2099" "238.4" "6.87" "2.57" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity" "Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "81704" "ENSG00000107099" "DOCK8" "A2A350; A2BDF2; A4FU78; B7ZLP0; E9PH09; hsa:81704; Q3MV16; Q5JPJ1; Q8NF50; Q8TEP1; Q8WUY2; Q9BYJ5; Q9H1Q2; Q9H1Q3; Q9H308; Q9H7P2" "" "CDC42 GTPase cycle; RHOJ GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production" "4" "0" "1.133" "0.768" "1.178" "1.127" "0.821" "1.225" "0.854" "1.043" "5.586" "35.5" "40.3" "27.3" "41.9" "40.0" "29.2" "43.5" "30.4" "37.1" "198.6" "" "" "" "" "" "" "" "" "" "" "21.3" "20.9" "15.1" "19.7" "18.6" "14.9" "20.2" "13.6" "20.1" "198.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5850236467978773586" "False" "High" "IsMasterProtein" "P40692" "DNA mismatch repair protein Mlh1 OS=Homo sapiens OX=9606 GN=MLH1 PE=1 SV=1" "0.003" "False" "2.640" "1" "1" "1" "1" "756" "84.5" "5.72" "2.02" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01119, Pf13589, Pf16413" "4292" "ENSG00000076242" "MLH1" "B4DI13; B4DQ11; E9PCU2; hsa:4292; P40692" "Ovarian infertility; Chromosomal and microsatellite instability in colorectal cancer ; Male infertility; DNA repair pathways, full network; p53 transcriptional gene network; DNA mismatch repair" "TP53 Regulates Transcription of DNA Repair Genes; Meiotic recombination; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MLH1; Defective Mismatch Repair Associated With PMS2" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1010665989767425721" "False" "High" "IsMasterProtein" "Q96CS3" "FAS-associated factor 2 OS=Homo sapiens OX=9606 GN=FAF2 PE=1 SV=2" "0.003" "False" "2.637" "2" "1" "1" "1" "445" "52.6" "5.62" "1.83" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00789, Pf14555, Pf21021" "23197" "ENSG00000113194" "FAF2" "hsa:23197; O94963; Q8IUF2; Q96CS3; Q9BRP2; Q9BVM7" "5q35 copy number variation" "RHOA GTPase cycle; Neutrophil degranulation" "3" "0" "0.812" "0.753" "0.980" "0.993" "1.139" "0.984" "1.001" "0.883" "0.950" "41.1" "33.3" "30.9" "40.3" "40.8" "46.8" "40.4" "41.1" "36.2" "39.0" "" "" "" "" "" "" "" "" "" "" "24.6" "17.3" "17.1" "18.9" "18.9" "24.0" "18.8" "18.4" "19.7" "39.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-985839782283071822" "False" "High" "IsMasterProtein" "P10619" "Lysosomal protective protein OS=Homo sapiens OX=9606 GN=CTSA PE=1 SV=2" "0.003" "False" "2.635" "3" "1" "1" "1" "480" "54.4" "6.61" "0.00" "1" "protein metabolism;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00450" "5476" "ENSG00000064601" "CTSA" "B2R798; hsa:5476; P10619; Q561W6; Q5JZH1; Q96KJ2; Q9BR08; Q9BW68" "Ciliary landscape" "MHC class II antigen presentation; Neutrophil degranulation; Sialic acid metabolism; Glycosphingolipid catabolism; Defective NEU1 causes sialidosis" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8654405548002230634" "False" "High" "IsMasterProtein" "Q49B96" "Cytochrome c oxidase assembly protein COX19 OS=Homo sapiens OX=9606 GN=COX19 PE=1 SV=1" "0.003" "False" "2.633" "11" "1" "2" "1" "90" "10.4" "8.72" "4.94" "1" "cell organization and biogenesis;other biological processes" "cytosol;mitochondrion" "" "Pf06747" "90639" "ENSG00000240230" "COX19" "A4FTX0; hsa:90639; Q49B96" "Mitochondrial complex IV assembly" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial protein import" "5" "0" "0.805" "0.762" "0.930" "0.898" "0.690" "0.974" "0.713" "0.752" "0.621" "71.8" "57.8" "54.7" "66.7" "64.5" "49.6" "69.9" "51.2" "54.0" "44.6" "" "" "" "" "" "" "" "" "" "" "43.0" "30.0" "30.3" "31.3" "29.9" "25.4" "32.5" "23.0" "29.3" "44.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6460139479284416051" "False" "High" "IsMasterProtein" "Q86UK7" "E3 ubiquitin-protein ligase ZNF598 OS=Homo sapiens OX=9606 GN=ZNF598 PE=1 SV=1" "0.004" "False" "2.622" "1" "1" "1" "1" "904" "98.6" "8.40" "1.92" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "translation activity;other molecular function" "" "90850" "" "ZNF598" "hsa:90850; Q86UK7; Q8IW49; Q8N3D9; Q96FG3; Q9H7J3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "Not Found" "Not Found" "High" "High" "High" "Not Found" "High" "1" "" "-6426734383600856074" "False" "High" "IsMasterProtein" "O75030" "Microphthalmia-associated transcription factor OS=Homo sapiens OX=9606 GN=MITF PE=1 SV=2" "0.004" "False" "2.621" "2" "1" "1" "1" "526" "58.8" "6.33" "2.77" "1" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf11851, Pf15951" "4286" "ENSG00000187098" "MITF" "B4DJL2; D3K197; E9PFN0; O75030; Q14841; Q9P2V0; Q9P2V1; Q9P2V2; Q9P2Y8" "RANKL/RANK signaling pathway; Neural crest differentiation; Kit receptor signaling pathway; Melanoma; GPR143 in melanocytes and retinal pigment epithelium cells; Autophagy in pancreatic ductal adenocarcinoma; 15q11q13 copy number variation; Prostaglandin synthesis and regulation" "SUMOylation of transcription factors" "9" "0" "0.940" "1.019" "1.080" "1.010" "1.135" "1.172" "0.747" "0.946" "1.814" "51.9" "48.8" "52.9" "56.0" "52.4" "58.9" "60.8" "38.7" "49.1" "94.1" "" "" "" "" "" "" "" "" "" "" "31.0" "25.3" "29.3" "26.3" "24.3" "30.2" "28.3" "17.4" "26.6" "94.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2238397026184103268" "False" "High" "IsMasterProtein" "Q9ULU4" "MYND-type zinc finger-containing chromatin reader ZMYND8 OS=Homo sapiens OX=9606 GN=ZMYND8 PE=1 SV=2" "0.004" "False" "2.620" "2" "1" "1" "1" "1186" "131.6" "7.20" "0.00" "1" "cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00439, Pf00628, Pf00855, Pf12064" "23613" "ENSG00000101040" "ZMYND8" "B3KVL2; B7Z2A8; B7Z3E0; B7Z680; B7ZM62; E1P5U5; F5H0X3; H7C0U2; hsa:23613; J3KPU3; Q13517; Q2HXV1; Q2HXV2; Q2HXV3; Q2HXV4; Q2HXV7; Q2HXV8; Q2HXV9; Q2HXW0; Q2HXW1; Q2HXW2; Q4JJ94; Q4JJ95; Q5TH09; Q5TH11; Q6MZM1; Q8WXC5; Q9H1F3; Q9H1F4; Q9H1F5; Q9H1L8; Q9H1L9; Q9H2G5; Q9NYN3; Q9UIX6; Q9ULU4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "High" "High" "1" "" "3065352799485715425" "False" "High" "IsMasterProtein" "Q9P0P0" "E3 ubiquitin-protein ligase RNF181 OS=Homo sapiens OX=9606 GN=RNF181 PE=1 SV=1" "0.004" "False" "2.617" "5" "1" "2" "1" "153" "17.9" "5.06" "4.18" "1" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf13639" "51255" "ENSG00000168894" "RNF181" "hsa:51255; Q53H81; Q9P0P0" "" "E3 ubiquitin ligases ubiquitinate target proteins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3476524128370901588" "False" "High" "IsMasterProtein" "P53634" "Dipeptidyl peptidase 1 OS=Homo sapiens OX=9606 GN=CTSC PE=1 SV=2" "0.004" "False" "2.617" "2" "1" "4" "1" "463" "51.8" "6.99" "10.68" "1" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00112, Pf08773" "1075" "ENSG00000109861" "CTSC" "A8K7V2; B5MDD5; hsa:1075; P53634; Q2HIY8; Q53G93; Q71E75; Q71E76; Q7M4N9; Q7Z3G7; Q7Z5U7; Q8WY99; Q8WYA7; Q8WYA8" "" "Neutrophil degranulation; MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER" "4" "0" "0.938" "1.004" "1.074" "0.991" "0.955" "0.913" "0.893" "0.877" "0.564" "201.1" "188.7" "201.9" "216.0" "199.3" "192.1" "183.7" "179.5" "176.3" "113.5" "" "" "" "" "" "" "" "" "" "" "120.4" "98.0" "111.8" "101.4" "92.4" "98.3" "85.4" "80.6" "95.7" "113.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5119731611670534936" "False" "High" "IsMasterProtein" "O60610" "Protein diaphanous homolog 1 OS=Homo sapiens OX=9606 GN=DIAPH1 PE=1 SV=2" "0.004" "False" "2.616" "1" "1" "1" "1" "1272" "141.3" "5.41" "0.00" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02181, Pf06346, Pf06367, Pf06371" "1729" "ENSG00000131504" "DIAPH1" "A6NF18; B7ZKW2; E9PEZ2; hsa:1729; O60610; Q17RN4; Q59FH8; Q9UC76" "Microtubule cytoskeleton regulation; AGE/RAGE pathway; Focal adhesion; Type 2 papillary renal cell carcinoma; Regulation of actin cytoskeleton; G13 signaling pathway" "RHOC GTPase cycle; RHOA GTPase cycle; RHO GTPases Activate Formins; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; ERBB2 Regulates Cell Motility" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1799847195195984928" "False" "High" "IsMasterProtein" "Q5VYK3" "Proteasome adapter and scaffold protein ECM29 OS=Homo sapiens OX=9606 GN=ECPAS PE=1 SV=2" "0.004" "False" "2.610" "1" "1" "1" "1" "1845" "204.2" "7.12" "1.63" "1" "cell organization and biogenesis" "cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf12755, Pf13001" "23392" "ENSG00000136813" "ECPAS" "A0A804HJA4; B3KXF2; O15074; Q5VYK3; Q8WU82" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9155703229501675198" "False" "High" "IsMasterProtein" "P31751" "RAC-beta serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=AKT2 PE=1 SV=2" "0.004" "False" "2.606" "2" "1" "1" "1" "481" "55.7" "6.37" "2.04" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00169, Pf00433" "208" "ENSG00000105221" "AKT2" "B2RBD8; hsa:208; P31751; Q05BV0; Q0VAN0; Q0VAN1; Q68GC0" "AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; S1P receptor signal transduction; Cardiac hypertrophic response; Focal adhesion; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Lipid metabolism pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Congenital generalized lipodystrophy; Familial partial lipodystrophy; Alzheimer's disease; Acute myeloid leukemia; Sildenafil treatment; Female steroid hormones in cardiomyocyte energy metabolism; JAK-STAT signaling in the regulation of beta cells; Osteoarthritic chondrocyte hypertrophy; Artemisinin inhibition of uveal melanoma; ErbB signaling pathway; Toll-like receptor signaling pathway" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; Regulation of TP53 Degradation; CTLA4 inhibitory signaling; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; Deactivation of the beta-catenin transactivating complex; CD28 dependent PI3K/Akt signaling; TP53 Regulates Metabolic Genes; Downregulation of ERBB2:ERBB3 signaling; G beta:gamma signalling through PI3Kgamma; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; AKT phosphorylates targets in the cytosol; Regulation of TP53 Activity through Association with Co-factors; Activation of AKT2; VEGFR2 mediated vascular permeability; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; FLT3 Signaling; Negative regulation of the PI3K/AKT network; Regulation of TP53 Activity through Acetylation; RUNX2 regulates genes involved in cell migration; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry; Activation of BAD and translocation to mitochondria ; AKT-mediated inactivation of FOXO1A; PDE3B signalling; Inhibition of TSC complex formation by PKB" "83" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-618905356124197811" "False" "High" "IsMasterProtein" "Q9NQZ5" "StAR-related lipid transfer protein 7, mitochondrial OS=Homo sapiens OX=9606 GN=STARD7 PE=1 SV=2" "0.004" "False" "2.602" "2" "1" "1" "1" "370" "43.1" "8.95" "2.34" "1" "" "other membranes;mitochondrion" "other molecular function" "Pf01852" "56910" "ENSG00000084090" "STARD7" "D3DXG9; hsa:56910; Q53T44; Q6GU43; Q969M6; Q9NQZ5" "2q11.2 copy number variation syndrome" "Mitochondrial protein degradation; Synthesis of PC" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6897785543843873721" "False" "High" "IsMasterProtein" "Q7Z5J4" "Retinoic acid-induced protein 1 OS=Homo sapiens OX=9606 GN=RAI1 PE=1 SV=2" "0.004" "False" "2.600" "1" "1" "1" "1" "1906" "203.2" "8.79" "0.00" "1" "developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13771" "10743" "ENSG00000108557" "RAI1" "hsa:10743; Q7Z5J4; Q8N3B4; Q8ND08; Q8WU64; Q96JK5; Q9H1C1; Q9H1C2; Q9UF69" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Heme signaling; Circadian Clock" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "High" "High" "Not Found" "High" "Not Found" "High" "Not Found" "Not Found" "1" "" "-957867492455840150" "False" "High" "IsMasterProtein" "Q9NR82" "Potassium voltage-gated channel subfamily KQT member 5 OS=Homo sapiens OX=9606 GN=KCNQ5 PE=1 SV=3" "0.004" "False" "2.596" "1" "1" "1" "1" "932" "102.1" "9.48" "2.39" "1" "transport" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00520, Pf03520" "56479" "ENSG00000185760" "KCNQ5" "A6NKT6; A6PVT6; A8MSQ5; B4DS33; B5MC83; B7ZL37; F5GZV0; hsa:56479; Q17RE1; Q5VVP3; Q86W40; Q9NR82; Q9NRN0; Q9NYA6" "" "Voltage gated Potassium channels" "1" "0" "0.937" "0.928" "1.290" "1.201" "1.085" "1.293" "1.154" "1.053" "0.666" "77.0" "72.1" "71.5" "99.3" "92.5" "83.5" "99.6" "88.9" "81.1" "51.3" "" "" "" "" "" "" "" "" "" "" "46.1" "37.5" "39.6" "46.6" "42.9" "42.8" "46.3" "39.9" "44.0" "51.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8991505405555366750" "False" "High" "IsMasterProtein" "Q8TED0" "U3 small nucleolar RNA-associated protein 15 homolog OS=Homo sapiens OX=9606 GN=UTP15 PE=1 SV=3" "0.004" "False" "2.595" "2" "1" "1" "1" "518" "58.4" "9.11" "3.03" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "" "Pf00400, Pf09384" "84135" "ENSG00000164338" "UTP15" "B4DU75; B4DXK8; hsa:84135; Q6IA60; Q8TED0; Q96E08; Q9H9F8" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.073" "1.151" "1.100" "1.115" "1.213" "1.226" "1.142" "1.073" "0.769" "146.3" "157.0" "168.4" "160.9" "163.2" "177.5" "179.4" "167.1" "157.0" "112.6" "" "" "" "" "" "" "" "" "" "" "87.6" "81.6" "93.3" "75.5" "75.6" "90.9" "83.4" "75.0" "85.2" "112.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3537193466780696360" "False" "High" "IsMasterProtein" "P30047" "GTP cyclohydrolase 1 feedback regulatory protein OS=Homo sapiens OX=9606 GN=GCHFR PE=1 SV=3" "0.004" "False" "2.589" "10" "1" "3" "1" "84" "9.7" "6.54" "9.55" "1" "other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf06399" "2644" "ENSG00000137880" "GCHFR" "B2R4L6; B7ZLM8; hsa:2644; P30047; Q2M1Q2; Q99749" "" "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "1" "0" "0.957" "0.808" "0.963" "1.086" "0.968" "1.083" "1.062" "0.958" "0.561" "712.9" "682.1" "575.8" "686.7" "774.0" "689.8" "772.1" "757.3" "683.2" "399.7" "" "" "" "" "" "" "" "" "" "" "426.6" "354.5" "318.9" "322.4" "358.7" "353.1" "359.0" "340.0" "370.7" "399.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6535864909566568035" "False" "High" "IsMasterProtein" "O75367" "Core histone macro-H2A.1 OS=Homo sapiens OX=9606 GN=MACROH2A1 PE=1 SV=5" "0.004" "False" "2.587" "3" "1" "1" "1" "369" "39.2" "9.83" "2.15" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00125, Pf01661, Pf16211" "9555" "ENSG00000113648" "MACROH2A1" "hsa:9555; O75367; O75377; Q503A8; Q7Z5E3; Q96D41; Q9H8P3; Q9UP96" "H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "" "2" "0" "0.776" "1.112" "1.063" "0.972" "0.899" "1.109" "1.141" "1.197" "0.915" "52.9" "41.0" "58.9" "56.2" "51.4" "47.6" "58.7" "60.4" "63.4" "48.4" "" "" "" "" "" "" "" "" "" "" "31.7" "21.3" "32.6" "26.4" "23.8" "24.4" "27.3" "27.1" "34.4" "48.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3667791429140774240" "False" "High" "IsMasterProtein" "Q9NUM4" "Transmembrane protein 106B OS=Homo sapiens OX=9606 GN=TMEM106B PE=1 SV=2" "0.004" "False" "2.586" "3" "1" "1" "1" "274" "31.1" "6.99" "2.13" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf07092, Pf21002" "54664" "ENSG00000106460" "TMEM106B" "A4D108; hsa:54664; Q53FL9; Q8N4L0; Q9NUM4" "" "" "0" "0" "0.883" "0.982" "0.960" "0.906" "0.781" "0.987" "0.944" "0.982" "0.658" "68.4" "60.4" "67.1" "65.7" "62.0" "53.4" "67.5" "64.6" "67.1" "45.0" "" "" "" "" "" "" "" "" "" "" "40.9" "31.4" "37.2" "30.8" "28.7" "27.3" "31.4" "29.0" "36.4" "45.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8650406954565681421" "False" "High" "IsMasterProtein" "P48426" "Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha OS=Homo sapiens OX=9606 GN=PIP4K2A PE=1 SV=2" "0.004" "False" "2.580" "3" "1" "1" "1" "406" "46.2" "6.99" "2.42" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf01504" "5305" "ENSG00000150867" "PIP4K2A" "B0YJ66; B4DGX2; D3DRV1; hsa:5305; P48426; P53807; Q5VUX3" "Regulation of actin cytoskeleton; G13 signaling pathway" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3372054881013806202" "False" "High" "IsMasterProtein" "Q9NVZ3" "Adaptin ear-binding coat-associated protein 2 OS=Homo sapiens OX=9606 GN=NECAP2 PE=1 SV=1" "0.004" "False" "2.569" "3" "1" "1" "1" "263" "28.3" "8.38" "3.24" "1" "transport" "other membranes" "" "Pf07933" "55707" "ENSG00000157191; ENSG00000291380" "NECAP2" "B4DY19; E9PGQ8; hsa:55707; Q5VSU4; Q5VSU5; Q9H7L1; Q9H8L1; Q9NVZ3" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "0.966" "1.048" "0.839" "1.170" "1.049" "1.066" "0.946" "1.024" "1.421" "117.9" "113.9" "123.6" "98.9" "137.9" "123.7" "125.6" "111.6" "120.8" "167.6" "" "" "" "" "" "" "" "" "" "" "70.5" "59.2" "68.4" "46.4" "63.9" "63.3" "58.4" "50.1" "65.5" "167.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8657870357206849576" "False" "High" "IsMasterProtein" "Q9Y2Y0" "ADP-ribosylation factor-like protein 2-binding protein OS=Homo sapiens OX=9606 GN=ARL2BP PE=1 SV=1" "0.004" "False" "2.561" "7" "1" "1" "1" "163" "18.8" "4.35" "2.15" "1" "signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf11527" "23568" "ENSG00000102931" "ARL2BP" "B3KQJ5; hsa:23568; Q504R0; Q9Y2Y0" "Ciliopathies" "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8872418037025781977" "False" "High" "IsMasterProtein" "Q5VTB9" "E3 ubiquitin-protein ligase RNF220 OS=Homo sapiens OX=9606 GN=RNF220 PE=1 SV=1" "0.004" "False" "2.558" "2" "1" "1" "1" "566" "62.7" "6.04" "2.82" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13923, Pf15926" "55182" "ENSG00000187147" "RNF220" "B3KPJ3; B4DLZ9; E9PCS1; hsa:55182; Q4KMX2; Q5VTB9; Q9NVP6" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2974134927255505490" "False" "High" "IsMasterProtein" "Q6VY07" "Phosphofurin acidic cluster sorting protein 1 OS=Homo sapiens OX=9606 GN=PACS1 PE=1 SV=2" "0.004" "False" "2.557" "1" "1" "2" "1" "963" "104.8" "7.74" "1.63" "1" "other biological processes" "cytosol;ER/Golgi" "other molecular function" "Pf10254" "55690" "ENSG00000175115" "PACS1" "hsa:55690; Q6PJY6; Q6PKB6; Q6VY07; Q7Z590; Q7Z5W4; Q8N8K6; Q96MW0; Q9NW92; Q9ULP5" "" "Nef mediated downregulation of MHC class I complex cell surface expression" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7848338417616042821" "False" "High" "IsMasterProtein" "P35270" "Sepiapterin reductase OS=Homo sapiens OX=9606 GN=SPR PE=1 SV=1" "0.004" "False" "2.550" "3" "1" "1" "1" "261" "28.0" "8.05" "1.92" "1" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00106" "6697" "ENSG00000116096" "SPR" "A8K741; D6W5H2; hsa:6697; P35270; Q53GI9; Q9UBB1" "" "eNOS activation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "2" "0" "0.846" "0.903" "1.299" "1.394" "0.888" "1.657" "1.192" "0.740" "1.487" "19.2" "16.3" "17.3" "25.0" "26.8" "17.1" "31.8" "22.9" "14.2" "28.6" "" "" "" "" "" "" "" "" "" "" "11.5" "8.4" "9.6" "11.7" "12.4" "8.7" "14.8" "10.3" "7.7" "28.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5568233219206595783" "False" "High" "IsMasterProtein" "Q9ULT8" "E3 ubiquitin-protein ligase HECTD1 OS=Homo sapiens OX=9606 GN=HECTD1 PE=1 SV=4" "0.004" "False" "2.548" "1" "1" "1" "1" "2610" "289.2" "5.35" "0.00" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf00632, Pf06701, Pf07738, Pf12796, Pf18410" "25831" "ENSG00000092148" "HECTD1" "D3DS86; hsa:25831; Q6P445; Q86VJ1; Q96F34; Q9UFZ7; Q9ULT8" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "Not Found" "High" "High" "High" "High" "High" "High" "1" "" "-5140965250815444674" "False" "High" "IsMasterProtein" "Q9ULJ6" "Zinc finger MIZ domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZMIZ1 PE=1 SV=3" "0.004" "False" "2.542" "1" "1" "1" "1" "1067" "115.4" "7.46" "2.80" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02891, Pf18028" "57178" "ENSG00000108175" "ZMIZ1" "hsa:57178; Q5JSH9; Q7Z7E6; Q9ULJ6" "Androgen receptor signaling pathway" "" "1" "0" "1.293" "1.115" "1.204" "1.160" "1.193" "1.179" "1.227" "1.135" "0.961" "117.0" "151.3" "130.5" "140.9" "135.8" "139.7" "138.0" "143.6" "132.9" "112.4" "" "" "" "" "" "" "" "" "" "" "70.0" "78.6" "72.3" "66.1" "62.9" "71.5" "64.2" "64.5" "72.1" "112.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5703781762481200822" "False" "High" "IsMasterProtein" "Q04941" "Proteolipid protein 2 OS=Homo sapiens OX=9606 GN=PLP2 PE=1 SV=1" "0.004" "False" "2.534" "9" "1" "1" "1" "152" "16.7" "7.24" "0.00" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi" "transporter activity;other molecular function" "Pf01284" "5355" "ENSG00000102007" "PLP2" "A6NDT7; hsa:5355; Q04941; Q32MM8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5315083588279200367" "False" "High" "IsMasterProtein" "Q96FZ2" "Abasic site processing protein HMCES OS=Homo sapiens OX=9606 GN=HMCES PE=1 SV=1" "0.004" "False" "2.530" "4" "1" "1" "1" "354" "40.5" "8.15" "2.20" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf02586" "56941" "ENSG00000183624" "HMCES" "A6NJR9; hsa:56941; Q96FZ2; Q96G34; Q9NRP3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2135832377467312061" "False" "High" "IsMasterProtein" "Q9UHC7" "E3 ubiquitin-protein ligase makorin-1 OS=Homo sapiens OX=9606 GN=MKRN1 PE=1 SV=3" "0.004" "False" "2.527" "2" "1" "1" "1" "482" "53.3" "5.14" "1.93" "1" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00097, Pf14608, Pf15815, Pf18044" "23608" "ENSG00000133606" "MKRN1" "A4D1T7; B3KXB4; Q256Y7; Q59G11; Q6GSF1; Q9H0G0; Q9UEZ7; Q9UHC7; Q9UHW2" "" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of PTEN stability and activity; AKT phosphorylates targets in the cytosol" "3" "0" "0.909" "1.200" "0.572" "1.009" "0.875" "0.770" "0.801" "1.064" "0.856" "32.9" "29.9" "39.5" "18.8" "33.2" "28.8" "25.3" "26.3" "35.0" "28.2" "" "" "" "" "" "" "" "" "" "" "19.7" "15.5" "21.9" "8.8" "15.4" "14.7" "11.8" "11.8" "19.0" "28.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6046703873344704710" "False" "High" "IsMasterProtein" "Q9H1D9" "DNA-directed RNA polymerase III subunit RPC6 OS=Homo sapiens OX=9606 GN=POLR3F PE=1 SV=1" "0.005" "False" "2.523" "3" "1" "1" "1" "316" "35.7" "6.11" "2.32" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05158" "10621" "ENSG00000132664" "POLR3F" "A8K4C7; hsa:10621; O15319; Q9H1D9" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; TAR syndrome" "Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; RNA Polymerase III Chain Elongation" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8474719942598486325" "False" "High" "IsMasterProtein" "Q8WYA6" "Beta-catenin-like protein 1 OS=Homo sapiens OX=9606 GN=CTNNBL1 PE=1 SV=1" "0.005" "False" "2.520" "2" "1" "1" "1" "563" "65.1" "5.05" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08216" "56259" "ENSG00000132792" "CTNNBL1" "B4DE16; hsa:56259; Q0VAL9; Q0VAM0; Q53HI8; Q5JWZ2; Q5JWZ3; Q5JWZ7; Q5JWZ8; Q8N454; Q8NCL2; Q8TBD6; Q8WYA6; Q96KD2; Q9H7A5; Q9NQF9; Q9NTX0; Q9Y3M7" "" "mRNA Splicing - Major Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4245870540652335533" "False" "High" "IsMasterProtein" "Q8N8N7" "Prostaglandin reductase 2 OS=Homo sapiens OX=9606 GN=PTGR2 PE=1 SV=1" "0.005" "False" "2.519" "2" "1" "1" "1" "351" "38.5" "5.41" "2.30" "1" "other metabolic processes" "other cell component" "other molecular function" "Pf00107, Pf16884" "145482" "ENSG00000140043" "PTGR2" "hsa:145482; Q3L8A4; Q6MZH8; Q8N8N7" "Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-6-fatty acids in senescence" "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2014146262064774288" "False" "High" "IsMasterProtein" "P09001" "Large ribosomal subunit protein uL3m OS=Homo sapiens OX=9606 GN=MRPL3 PE=1 SV=1" "0.005" "False" "2.518" "3" "1" "1" "1" "348" "38.6" "9.48" "3.20" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00297" "11222" "ENSG00000114686" "MRPL3" "hsa:11222; P09001; Q6IBT2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2332005078854859868" "False" "High" "IsMasterProtein" "Q9BWT6" "Meiotic nuclear division protein 1 homolog OS=Homo sapiens OX=9606 GN=MND1 PE=1 SV=1" "0.005" "False" "2.517" "5" "1" "1" "1" "205" "23.7" "8.19" "2.17" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism" "nucleus" "nucleic acid binding activity" "Pf03962, Pf18517" "84057" "ENSG00000121211" "MND1" "B2R5F9; hsa:84057; Q9BWT6" "Primary ovarian insufficiency" "Meiotic recombination" "2" "0" "0.707" "0.963" "0.822" "1.378" "0.957" "1.058" "1.235" "0.829" "1.239" "32.8" "23.2" "31.6" "26.9" "45.1" "31.4" "34.7" "40.5" "27.2" "40.6" "" "" "" "" "" "" "" "" "" "" "19.6" "12.0" "17.5" "12.6" "20.9" "16.1" "16.1" "18.2" "14.7" "40.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5375440904508103637" "False" "High" "IsMasterProtein" "Q6ZSJ8" "Uncharacterized protein C1orf122 OS=Homo sapiens OX=9606 GN=C1orf122 PE=1 SV=2" "0.005" "False" "2.516" "8" "1" "1" "1" "110" "11.5" "6.73" "2.82" "1" "" "" "" "Pf15855" "127687" "ENSG00000197982" "C1orf122" "A2RQF4; E9PQ13; hsa:127687; Q56A71; Q6ZSJ8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3152037375536322199" "False" "High" "IsMasterProtein" "P68402" "Platelet-activating factor acetylhydrolase IB subunit alpha2 OS=Homo sapiens OX=9606 GN=PAFAH1B2 PE=1 SV=1" "0.005" "False" "2.513" "4" "1" "1" "1" "229" "25.6" "5.92" "2.53" "1" "other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf13472" "5049" "ENSG00000168092" "PAFAH1B2" "A8DPS5; A8DPS6; A8DPS7; E9PEJ5; E9PLP3; hsa:5049; O00687; P68402; Q29459; Q6IBR6" "PAFAH1B1 copy number variation" "Neutrophil degranulation; COPI-independent Golgi-to-ER retrograde traffic" "3" "0" "0.990" "1.322" "1.321" "1.574" "1.061" "1.088" "0.959" "1.138" "1.811" "40.7" "40.2" "53.8" "53.7" "64.0" "43.1" "44.3" "39.0" "46.3" "73.7" "" "" "" "" "" "" "" "" "" "" "24.3" "20.9" "29.8" "25.2" "29.7" "22.1" "20.6" "17.5" "25.1" "73.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2516739525907873838" "False" "High" "IsMasterProtein" "Q96RN5" "Mediator of RNA polymerase II transcription subunit 15 OS=Homo sapiens OX=9606 GN=MED15 PE=1 SV=2" "0.005" "False" "2.510" "2" "1" "1" "1" "788" "86.7" "9.42" "0.00" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09606, Pf21538, Pf21539" "51586" "ENSG00000099917" "MED15" "D3DX31; D3DX32; hsa:51586; O15413; Q6IC31; Q8NF16; Q96CT0; Q96IH7; Q96RN5; Q9P1T3" "Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; 22q11.2 copy number variation syndrome" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "High" "1" "" "-8332128719972757989" "False" "High" "IsMasterProtein" "Q8IY67" "Ribonucleoprotein PTB-binding 1 OS=Homo sapiens OX=9606 GN=RAVER1 PE=1 SV=1" "0.005" "False" "2.509" "3" "1" "1" "1" "606" "63.8" "8.48" "2.12" "1" "" "nucleus;other cell component" "" "Pf00076" "125950" "" "RAVER1" "A6NMU4; hsa:125950; Q8IY60; Q8IY67; Q8TF24" "" "" "0" "0" "0.957" "0.879" "0.926" "0.572" "1.144" "0.687" "0.790" "0.652" "2.081" "21.1" "20.2" "18.5" "19.5" "12.0" "24.1" "14.5" "16.7" "13.7" "43.9" "" "" "" "" "" "" "" "" "" "" "12.6" "10.5" "10.3" "9.2" "5.6" "12.3" "6.7" "7.5" "7.5" "43.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4412220755654312839" "False" "High" "IsMasterProtein" "Q15652" "Probable JmjC domain-containing histone demethylation protein 2C OS=Homo sapiens OX=9606 GN=JMJD1C PE=1 SV=2" "0.005" "False" "2.509" "0" "1" "1" "1" "2540" "284.3" "7.87" "2.20" "1" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "221037" "ENSG00000171988" "JMJD1C" "A0T124; hsa:221037; Q15652; Q5SQZ8; Q5SQZ9; Q5SR00; Q7Z3E7; Q8N3U0; Q96KB9; Q9P2G7" "Pathways affected in adenoid cystic carcinoma" "Factors involved in megakaryocyte development and platelet production" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-275352047723705183" "False" "High" "IsMasterProtein" "Q8TF09" "Dynein light chain roadblock-type 2 OS=Homo sapiens OX=9606 GN=DYNLRB2 PE=1 SV=1" "0.006" "False" "2.499" "13" "1" "1" "1" "96" "10.8" "7.50" "2.06" "1" "other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf03259" "83657" "ENSG00000168589" "DYNLRB2" "hsa:83657; Q8TF09" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome" "Intraflagellar transport" "4" "0" "0.851" "0.772" "0.918" "1.243" "1.041" "0.841" "0.720" "0.956" "0.317" "22.8" "19.4" "17.6" "21.0" "28.4" "23.8" "19.2" "16.4" "21.8" "7.2" "" "" "" "" "" "" "" "" "" "" "13.7" "10.1" "9.8" "9.8" "13.2" "12.2" "8.9" "7.4" "11.8" "7.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3718906404474103384" "False" "High" "IsMasterProtein" "P19174" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Homo sapiens OX=9606 GN=PLCG1 PE=1 SV=1" "0.006" "False" "2.496" "1" "1" "1" "1" "1290" "148.4" "6.05" "2.13" "1" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018, Pf00168, Pf00169, Pf00387, Pf00388" "5335" "ENSG00000124181" "PLCG1" "B7ZLY7; B9EGH4; E1P5W4; hsa:5335; P19174; Q2V575" "Angiogenesis; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; PDGF pathway; Primary focal segmental glomerulosclerosis (FSGS); T cell receptor and co-stimulatory signaling; Myometrial relaxation and contraction pathways; Kit receptor signaling pathway; MFAP5-mediated ovarian cancer cell motility and invasiveness; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; GPR40 pathway; PDGFR-beta pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling; Non-small cell lung cancer; EGF/EGFR signaling pathway; Resistin as a regulator of inflammation; Fragile X syndrome; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; mBDNF and proBDNF regulation of GABA neurotransmission; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis; GDNF signaling; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; ErbB signaling pathway; T-cell receptor signaling pathway" "ISG15 antiviral mechanism; Generation of second messenger molecules; Role of phospholipids in phagocytosis; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Signaling by ALK fusions and activated point mutants; RET signaling; Downstream signal transduction; Signaling by ALK; DAP12 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; EGFR interacts with phospholipase C-gamma; Signaling by FGFR1 in disease; Synthesis of IP3 and IP4 in the cytosol; Phospholipase C-mediated cascade: FGFR1; Phospholipase C-mediated cascade; FGFR2; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Phospholipase C-mediated cascade; FGFR3; Phospholipase C-mediated cascade; FGFR4; Signaling by FGFR3 in disease; DAG and IP3 signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Role of second messengers in netrin-1 signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; PLCG1 events in ERBB2 signaling; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; PLC-gamma1 signalling; PECAM1 interactions; Activated NTRK2 signals through PLCG1; Activated NTRK3 signals through PLCG1" "76" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8950408743700017704" "False" "High" "IsMasterProtein" "O60645" "Exocyst complex component 3 OS=Homo sapiens OX=9606 GN=EXOC3 PE=1 SV=3" "0.006" "False" "2.494" "1" "1" "1" "1" "745" "85.5" "6.29" "1.99" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf06046" "11336" "ENSG00000180104" "EXOC3" "hsa:11336; O60645; Q6P2E8; Q8TEN6; Q8WUW0; Q96DI4" "Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "945913478307562709" "False" "High" "IsMasterProtein" "Q9Y2Q9" "Small ribosomal subunit protein bS1m OS=Homo sapiens OX=9606 GN=MRPS28 PE=1 SV=1" "0.006" "False" "2.484" "5" "1" "1" "1" "187" "20.8" "9.10" "2.35" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf10246" "28957" "ENSG00000147586" "MRPS28" "B2RDZ7; hsa:28957; Q96Q21; Q9Y2Q9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2230295239776997928" "False" "High" "IsMasterProtein" "Q969W3" "Protein VCF1 OS=Homo sapiens OX=9606 GN=VCF1 PE=1 SV=2" "0.006" "False" "2.483" "13" "1" "1" "1" "186" "19.5" "11.27" "2.14" "1" "" "" "" "Pf15434" "84923" "ENSG00000133193" "VCF1" "B4E339; hsa:84923; Q969W3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8494734003636031426" "False" "High" "IsMasterProtein" "Q8N2Z9" "Centromere protein S OS=Homo sapiens OX=9606 GN=CENPS PE=1 SV=1" "0.006" "False" "2.479" "9" "1" "1" "1" "138" "15.9" "6.05" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15630" "100526739; 378708" "ENSG00000175279" "CENPS" "hsa:100526739; hsa:378708; Q8N2Z9; Q8NFE5; Q8NFG5" "DNA repair pathways, full network" "Fanconi Anemia Pathway; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PKR-mediated signaling; Deposition of new CENPA-containing nucleosomes at the centromere" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8560465734379748063" "False" "High" "IsMasterProtein" "Q9NP77" "RNA polymerase II subunit A C-terminal domain phosphatase SSU72 OS=Homo sapiens OX=9606 GN=SSU72 PE=1 SV=1" "0.006" "False" "2.478" "6" "1" "1" "1" "194" "22.6" "5.33" "1.84" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04722" "29101" "ENSG00000160075" "SSU72" "hsa:29101; Q9BZS6; Q9H933; Q9NP77" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "Not Found" "High" "High" "High" "1" "" "4671672968224421805" "False" "High" "IsMasterProtein" "Q9NVK5" "FGFR1 oncogene partner 2 OS=Homo sapiens OX=9606 GN=FGFR1OP2 PE=1 SV=1" "0.006" "False" "2.477" "6" "1" "1" "1" "253" "29.4" "6.00" "2.13" "1" "stress response" "cytosol" "other molecular function" "Pf05769" "26127" "ENSG00000111790" "FGFR1OP2" "hsa:26127; Q6R955; Q8N5L7; Q9NVK5; Q9P034; Q9UFK8" "" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "2" "0" "1.087" "1.273" "1.383" "1.221" "1.457" "1.033" "1.022" "1.176" "1.465" "24.7" "26.8" "31.4" "34.1" "30.1" "36.0" "25.5" "25.2" "29.0" "36.1" "" "" "" "" "" "" "" "" "" "" "14.8" "13.9" "17.4" "16.0" "14.0" "18.4" "11.9" "11.3" "15.7" "36.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7369433181564394735" "False" "High" "IsMasterProtein" "P08708" "Small ribosomal subunit protein eS17 OS=Homo sapiens OX=9606 GN=RPS17 PE=1 SV=2" "0.006" "False" "2.475" "7" "1" "2" "1" "135" "15.5" "9.85" "5.09" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00833" "6218" "ENSG00000182774; ENSG00000278229" "RPS17" "B2R4U4; hsa:6218; P08708; P0CW22" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.955" "0.865" "0.910" "1.079" "1.075" "0.965" "0.829" "0.858" "1.432" "354.6" "338.6" "306.9" "322.9" "382.7" "381.2" "342.4" "294.0" "304.4" "507.7" "" "" "" "" "" "" "" "" "" "" "212.2" "176.0" "170.0" "151.6" "177.4" "195.1" "159.2" "132.0" "165.2" "507.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6108137657648573585" "False" "High" "IsMasterProtein" "O95571" "Persulfide dioxygenase ETHE1, mitochondrial OS=Homo sapiens OX=9606 GN=ETHE1 PE=1 SV=2" "0.006" "False" "2.470" "6" "1" "1" "1" "254" "27.9" "6.83" "1.63" "1" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00753" "23474" "ENSG00000105755" "ETHE1" "hsa:23474; O95571; Q96HR0; Q9H001" "" "Sulfide oxidation to sulfate" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7521593605618506386" "False" "High" "IsMasterProtein" "Q02556" "Interferon regulatory factor 8 OS=Homo sapiens OX=9606 GN=IRF8 PE=1 SV=2" "0.006" "False" "2.470" "2" "1" "2" "1" "426" "48.3" "6.77" "4.54" "1" "other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3394" "ENSG00000140968" "IRF8" "A0AV82; hsa:3394; Q02556" "Vitamin D receptor pathway; Development of pulmonary dendritic cells and macrophage subsets; Extrafollicular and follicular B cell activation by SARS-CoV-2; 2q37 copy number variation syndrome; Type II interferon signaling" "Interferon gamma signaling; Interferon alpha/beta signaling" "7" "0" "1.051" "0.959" "0.955" "1.039" "0.913" "1.456" "0.962" "1.146" "2.663" "38.2" "40.1" "36.6" "36.5" "39.7" "34.9" "55.6" "36.7" "43.8" "101.7" "" "" "" "" "" "" "" "" "" "" "22.9" "20.9" "20.3" "17.1" "18.4" "17.9" "25.9" "16.5" "23.8" "101.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8618924530113613764" "False" "High" "IsMasterProtein" "Q9UPT6" "C-Jun-amino-terminal kinase-interacting protein 3 OS=Homo sapiens OX=9606 GN=MAPK8IP3 PE=1 SV=3" "0.006" "False" "2.470" "1" "1" "1" "1" "1336" "147.4" "5.40" "1.99" "1" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf09744, Pf16471, Pf19056" "23162" "ENSG00000138834" "MAPK8IP3" "A2A2B3; A7E2B3; hsa:23162; Q96RY4; Q9H4I4; Q9H7P1; Q9NUG0; Q9UPT6" "MAPK signaling pathway" "" "1" "0" "0.974" "1.094" "1.166" "1.766" "1.577" "1.231" "0.586" "1.076" "3.063" "13.1" "12.8" "14.4" "15.3" "23.2" "20.7" "16.2" "7.7" "14.1" "40.3" "" "" "" "" "" "" "" "" "" "" "7.9" "6.7" "8.0" "7.2" "10.8" "10.6" "7.5" "3.5" "7.7" "40.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2733253045392511170" "False" "High" "IsMasterProtein" "P23297" "Protein S100-A1 OS=Homo sapiens OX=9606 GN=S100A1 PE=1 SV=2" "0.006" "False" "2.469" "7" "1" "1" "1" "94" "10.5" "4.50" "2.29" "1" "signal transduction;other biological processes" "non-structural extracellular;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00036, Pf01023" "6271" "ENSG00000160678" "S100A1" "B2R5D9; hsa:6271; P23297; Q5T7Y3" "" "ER-Phagosome pathway; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1231047339708811007" "False" "High" "IsMasterProtein" "O00203" "AP-3 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP3B1 PE=1 SV=3" "0.006" "False" "2.467" "1" "1" "1" "1" "1094" "121.2" "6.04" "2.47" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf14796, Pf14797" "8546" "ENSG00000132842" "AP3B1" "E5RJ68; hsa:8546; O00203; O00580; Q7Z393; Q9HD66" "" "Golgi Associated Vesicle Biogenesis; Signaling by BRAF and RAF1 fusions" "2" "0" "0.977" "0.982" "0.909" "0.723" "1.230" "0.831" "0.738" "1.189" "3.519" "31.8" "31.1" "31.2" "28.9" "23.0" "39.2" "26.5" "23.5" "37.9" "112.0" "" "" "" "" "" "" "" "" "" "" "19.1" "16.2" "17.3" "13.6" "10.7" "20.0" "12.3" "10.6" "20.5" "112.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1371524125527115551" "False" "High" "IsMasterProtein" "Q9NZM3" "Intersectin-2 OS=Homo sapiens OX=9606 GN=ITSN2 PE=1 SV=3" "0.006" "False" "2.466" "0" "1" "1" "1" "1697" "193.3" "8.12" "2.79" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00168, Pf00621, Pf07653, Pf12763, Pf14604, Pf16652" "50618" "ENSG00000198399" "ITSN2" "O95062; Q15812; Q9HAK4; Q9NXE6; Q9NYG0; Q9NZM2; Q9NZM3; Q9ULG4" "" "Cargo recognition for clathrin-mediated endocytosis; RHOU GTPase cycle" "3" "0" "1.076" "1.541" "1.221" "0.876" "1.447" "1.543" "0.382" "0.926" "10.863" "27.2" "29.2" "41.9" "33.2" "23.8" "39.3" "41.9" "10.4" "25.2" "295.1" "" "" "" "" "" "" "" "" "" "" "16.3" "15.2" "23.2" "15.6" "11.0" "20.1" "19.5" "4.7" "13.7" "295.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1239693809215146352" "False" "High" "IsMasterProtein" "P37275" "Zinc finger E-box-binding homeobox 1 OS=Homo sapiens OX=9606 GN=ZEB1 PE=1 SV=2" "0.006" "False" "2.461" "1" "1" "1" "1" "1124" "124.0" "4.94" "2.08" "1" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf05605" "6935" "ENSG00000148516" "ZEB1" "B4DJV0; B4DUW9; E9PCM7; F5H4I8; hsa:6935; P37275; Q12924; Q13800; Q2KJ05; Q5T968; Q5VZ84; Q8NB68" "Hypoxia-mediated EMT and stemness; TGF-beta signaling pathway; Clear cell renal cell carcinoma pathways; Epithelial to mesenchymal transition in colorectal cancer; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; CCL18 signaling pathway; Hypertrophy model" "Interleukin-4 and Interleukin-13 signaling" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7491273576453503015" "False" "High" "IsMasterProtein" "Q9BYN0" "Sulfiredoxin-1 OS=Homo sapiens OX=9606 GN=SRXN1 PE=1 SV=2" "0.006" "False" "2.455" "7" "1" "1" "1" "137" "14.3" "8.19" "1.95" "1" "stress response;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "" "140809" "ENSG00000271303" "SRXN1" "B2R543; hsa:140809; Q8NDM3; Q96AK6; Q9BYN0" "Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling" "NFE2L2 regulating anti-oxidant/detoxification enzymes" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6481945204603063978" "False" "High" "IsMasterProtein" "Q9UBB6" "Neurochondrin OS=Homo sapiens OX=9606 GN=NCDN PE=1 SV=1" "0.006" "False" "2.453" "1" "1" "1" "1" "729" "78.8" "5.48" "2.68" "1" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf05536" "23154" "ENSG00000020129" "NCDN" "D3DPR9; hsa:23154; Q9UBB6; Q9UBY2; Q9Y4A6; Q9Y4D9" "Splicing factor NOVA regulated synaptic proteins" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5100891898626735389" "False" "High" "IsMasterProtein" "Q86WA6" "Valacyclovir hydrolase OS=Homo sapiens OX=9606 GN=BPHL PE=1 SV=1" "0.006" "False" "2.452" "2" "1" "1" "1" "291" "32.5" "9.14" "3.05" "1" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00561" "670" "ENSG00000137274" "BPHL" "hsa:670; Q00306; Q13855; Q3KP51; Q86WA6" "" "Phase I - Functionalization of compounds" "1" "0" "1.099" "0.916" "0.946" "1.019" "1.027" "1.029" "0.852" "0.943" "1.037" "206.7" "227.1" "189.3" "195.5" "210.5" "212.2" "212.7" "176.0" "195.0" "214.3" "" "" "" "" "" "" "" "" "" "" "123.7" "118.0" "104.8" "91.8" "97.6" "108.6" "98.9" "79.0" "105.8" "214.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5217952952055268548" "False" "High" "IsMasterProtein" "P49207" "Large ribosomal subunit protein eL34 OS=Homo sapiens OX=9606 GN=RPL34 PE=1 SV=3" "0.006" "False" "2.451" "7" "1" "1" "1" "117" "13.3" "11.47" "2.13" "1" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01199" "6164" "ENSG00000109475" "RPL34" "hsa:6164; P49207; Q6FG66; Q9BUZ2" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-212858070142576811" "False" "High" "IsMasterProtein" "Q86VX2" "COMM domain-containing protein 7 OS=Homo sapiens OX=9606 GN=COMMD7 PE=1 SV=2" "0.006" "False" "2.447" "4" "1" "1" "1" "200" "22.5" "5.92" "2.77" "1" "signal transduction;other biological processes" "other cell component" "other molecular function" "Pf07258, Pf21672" "149951" "ENSG00000149600" "COMMD7" "A2BHJ2; B3KTZ2; hsa:149951; Q5JYB0; Q86VX2; Q96SI7; Q9BW53" "" "Neddylation" "1" "0" "1.023" "1.129" "0.915" "0.950" "1.096" "1.032" "0.875" "0.977" "1.472" "127.0" "129.9" "143.4" "116.1" "120.6" "139.1" "131.0" "111.1" "124.0" "186.8" "" "" "" "" "" "" "" "" "" "" "76.0" "67.5" "79.4" "54.5" "55.9" "71.2" "60.9" "49.9" "67.3" "186.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3393024407889637945" "False" "High" "IsMasterProtein" "P63027" "Vesicle-associated membrane protein 2 OS=Homo sapiens OX=9606 GN=VAMP2 PE=1 SV=3" "0.006" "False" "2.447" "14" "1" "1" "1" "116" "12.7" "8.13" "0.00" "1" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00957" "6844" "ENSG00000220205" "VAMP2" "hsa:6844; P19065; P63027; Q9BUC2" "Synaptic vesicle pathway; Insulin signaling; 7q11.23 copy number variation syndrome; Galanin receptor pathway; Vasopressin-regulated water reabsorption; Sudden infant death syndrome (SIDS) susceptibility pathways" "Sensory processing of sound by inner hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Glutamate Neurotransmitter Release Cycle; Regulation of insulin secretion; Insulin processing; Cargo recognition for clathrin-mediated endocytosis; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; GABA synthesis, release, reuptake and degradation; Other interleukin signaling; Toxicity of tetanus toxin (tetX); Toxicity of botulinum toxin type B (botB); Toxicity of botulinum toxin type D (botD); Toxicity of botulinum toxin type G (botG); Toxicity of botulinum toxin type F (botF)" "28" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "Not Found" "Not Found" "High" "High" "Not Found" "High" "High" "High" "1" "" "1923018383904393967" "False" "High" "IsMasterProtein" "Q8TAP6" "Centrosomal protein of 76 kDa OS=Homo sapiens OX=9606 GN=CEP76 PE=1 SV=1" "0.006" "False" "2.440" "1" "1" "1" "1" "659" "74.4" "6.74" "2.46" "1" "other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf15627" "79959" "ENSG00000101624" "CEP76" "B0YJB2; B4DXG5; B4DZW1; hsa:79959; Q658N5; Q8TAP6; Q9H9U7" "Genes related to primary cilium development (based on CRISPR)" "Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2862738582169560407" "False" "High" "IsMasterProtein" "Q9H3S1" "Semaphorin-4A OS=Homo sapiens OX=9606 GN=SEMA4A PE=1 SV=2" "0.006" "False" "2.439" "1" "1" "1" "1" "761" "83.5" "6.84" "0.00" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes" "signal transduction activity or receptor binding" "Pf01403, Pf01437" "64218" "ENSG00000196189" "SEMA4A" "B2RDH8; B3KR76; hsa:64218; Q5TCI5; Q5TCJ6; Q8WUA9; Q9H3S1" "Neurogenesis regulation in the olfactory epithelium" "Other semaphorin interactions" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6342427626710048975" "False" "High" "IsMasterProtein" "Q96SW2" "Protein cereblon OS=Homo sapiens OX=9606 GN=CRBN PE=1 SV=1" "0.006" "False" "2.438" "3" "1" "1" "1" "442" "50.5" "5.63" "2.01" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf02190, Pf03226" "51185" "ENSG00000113851" "CRBN" "B2R6H4; C9IZA9; C9JAH6; hsa:51185; Q6AI62; Q6NVZ0; Q96SW2; Q9UHW4" "" "Potential therapeutics for SARS" "1" "0" "0.957" "0.783" "1.020" "1.246" "0.888" "1.142" "0.892" "0.794" "2.189" "33.7" "32.3" "26.4" "34.4" "42.0" "30.0" "38.6" "30.1" "26.8" "73.9" "" "" "" "" "" "" "" "" "" "" "20.2" "16.8" "14.6" "16.2" "19.5" "15.3" "17.9" "13.5" "14.5" "73.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5364683920046459506" "False" "High" "IsMasterProtein" "O75340" "Programmed cell death protein 6 OS=Homo sapiens OX=9606 GN=PDCD6 PE=1 SV=1" "0.006" "False" "2.435" "5" "1" "1" "1" "191" "21.9" "5.40" "2.22" "1" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13499" "10016" "ENSG00000249915" "PDCD6" "B2RD16; E7ESR3; hsa:10016; O75340; Q2YDC2; Q5TZS0" "Epithelial to mesenchymal transition in colorectal cancer" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9172177916429743793" "False" "High" "IsMasterProtein" "Q99816" "Tumor susceptibility gene 101 protein OS=Homo sapiens OX=9606 GN=TSG101 PE=1 SV=2" "0.006" "False" "2.432" "3" "1" "1" "1" "390" "43.9" "6.46" "2.06" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf05743, Pf09454" "7251" "ENSG00000074319" "TSG101" "hsa:7251; Q99816; Q9BUM5" "Ebola virus infection in host; 7q11.23 copy number variation syndrome" "HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3737855785058777273" "False" "High" "IsMasterProtein" "Q9NSP4" "Centromere protein M OS=Homo sapiens OX=9606 GN=CENPM PE=1 SV=1" "0.006" "False" "2.430" "6" "1" "1" "1" "180" "19.7" "7.20" "2.26" "1" "cell cycle OR cell proliferation" "cytosol;nucleus;other cell component" "" "Pf11111" "79019" "ENSG00000100162" "CENPM" "A7LM22; B1AHQ9; hsa:79019; Q6I9W3; Q9NSP4" "" "Separation of Sister Chromatids; Deposition of new CENPA-containing nucleosomes at the centromere; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7043642977461230788" "False" "High" "IsMasterProtein" "Q92575" "UBX domain-containing protein 4 OS=Homo sapiens OX=9606 GN=UBXN4 PE=1 SV=2" "0.006" "False" "2.429" "1" "1" "1" "1" "508" "56.7" "6.38" "2.52" "1" "stress response" "other membranes;cytosol;ER/Golgi;nucleus" "" "Pf00789" "23190" "ENSG00000144224" "UBXN4" "A8K9W4; hsa:23190; Q4ZG56; Q8IYM5; Q92575" "" "" "0" "0" "1.056" "1.013" "0.994" "1.299" "1.035" "1.129" "1.294" "1.013" "1.254" "82.2" "86.8" "83.3" "81.8" "106.8" "85.1" "92.9" "106.4" "83.3" "103.1" "" "" "" "" "" "" "" "" "" "" "49.2" "45.1" "46.1" "38.4" "49.5" "43.6" "43.2" "47.8" "45.2" "103.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2699158399968223668" "False" "High" "IsMasterProtein" "Q15311" "RalA-binding protein 1 OS=Homo sapiens OX=9606 GN=RALBP1 PE=1 SV=3" "0.006" "False" "2.424" "1" "1" "1" "1" "655" "76.0" "5.88" "0.00" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus" "transporter activity;enzyme regulator activity;other molecular function" "Pf00620, Pf20924" "10928" "ENSG00000017797" "RALBP1" "D3DUI0; hsa:10928; Q15311" "RalA downstream regulated genes; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "CDC42 GTPase cycle; RAC1 GTPase cycle" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7952691654267697192" "False" "High" "IsMasterProtein" "Q15067" "Peroxisomal acyl-coenzyme A oxidase 1 OS=Homo sapiens OX=9606 GN=ACOX1 PE=1 SV=3" "0.006" "False" "2.424" "1" "1" "1" "1" "660" "74.4" "8.16" "0.00" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;other cytoplasmic organelle" "other molecular function" "Pf01756, Pf02770, Pf14749" "51" "ENSG00000161533" "ACOX1" "A8K6X8; A8KAA0; B4DK61; F5GYQ8; hsa:51; Q12863; Q15067; Q15068; Q15101; Q16131; Q7Z3W5; Q9UD31" "Estrogen receptor pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-3 / omega-6 fatty acid synthesis" "TYSND1 cleaves peroxisomal proteins" "8" "0" "1.015" "1.282" "1.093" "1.213" "1.435" "1.317" "1.117" "1.442" "0.790" "24.7" "25.1" "31.6" "27.0" "29.9" "35.4" "32.5" "27.6" "35.6" "19.5" "" "" "" "" "" "" "" "" "" "" "14.8" "13.0" "17.5" "12.7" "13.9" "18.1" "15.1" "12.4" "19.3" "19.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1391272447933749932" "False" "High" "IsMasterProtein" "Q9UNI6" "Dual specificity protein phosphatase 12 OS=Homo sapiens OX=9606 GN=DUSP12 PE=1 SV=1" "0.006" "False" "2.424" "4" "1" "1" "1" "340" "37.7" "6.84" "2.51" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00782" "11266" "ENSG00000081721" "DUSP12" "hsa:11266; Q5VXA8; Q9UNI6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5281205603675225167" "False" "High" "IsMasterProtein" "Q9NX76" "CKLF-like MARVEL transmembrane domain-containing protein 6 OS=Homo sapiens OX=9606 GN=CMTM6 PE=1 SV=1" "0.006" "False" "2.422" "5" "1" "1" "1" "183" "20.4" "5.29" "2.16" "1" "transport;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "" "Pf01284" "54918" "ENSG00000091317" "CMTM6" "hsa:54918; Q6IAC4; Q9NX76" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4934809763916306973" "False" "High" "IsMasterProtein" "Q6ZS81" "WD repeat- and FYVE domain-containing protein 4 OS=Homo sapiens OX=9606 GN=WDFY4 PE=1 SV=3" "0.007" "False" "2.420" "0" "1" "1" "1" "3184" "353.4" "6.32" "2.59" "1" "other metabolic processes;other biological processes" "ER/Golgi;other cytoplasmic organelle" "" "Pf00400, Pf02138" "57705" "ENSG00000128815" "WDFY4" "B9ZVP2; hsa:57705; Q6ZS81; Q86WZ4; Q8N4A3; Q8TEN7; Q96BE1; Q9H7H8; Q9HCG5" "10q11.21q11.23 copy number variation syndrome" "" "1" "0" "0.957" "1.215" "1.848" "1.159" "1.143" "1.155" "0.889" "1.184" "4.026" "22.4" "21.4" "27.2" "41.3" "25.9" "25.6" "25.8" "19.9" "26.5" "90.1" "" "" "" "" "" "" "" "" "" "" "13.4" "11.1" "15.1" "19.4" "12.0" "13.1" "12.0" "8.9" "14.4" "90.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8018768357268208371" "False" "High" "IsMasterProtein" "Q9P1U0" "DNA-directed RNA polymerase I subunit RPA12 OS=Homo sapiens OX=9606 GN=POLR1H PE=1 SV=1" "0.007" "False" "2.419" "6" "1" "1" "1" "126" "13.9" "5.06" "2.81" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01096" "30834" "ENSG00000066379; ENSG00000206502; ENSG00000224859; ENSG00000233795; ENSG00000235176; ENSG00000235443; ENSG00000236808; ENSG00000236949" "POLR1H" "hsa:30834; Q9P1U0" "Pyrimidine metabolism; 2q13 copy number variation syndrome" "RNA Polymerase I Transcription Initiation; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-448736336253279631" "False" "High" "IsMasterProtein" "Q9Y2H0" "Disks large-associated protein 4 OS=Homo sapiens OX=9606 GN=DLGAP4 PE=1 SV=3" "0.007" "False" "2.419" "2" "1" "1" "1" "992" "107.9" "7.08" "0.00" "1" "other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf03359" "22839" "ENSG00000080845" "DLGAP4" "E1P5T5; hsa:22839; Q5QPG4; Q5T2Y4; Q5T2Y5; Q9H137; Q9H138; Q9H1L7; Q9Y2H0" "" "Neurexins and neuroligins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2756715641617958921" "False" "High" "IsMasterProtein" "Q8N0T1" "Ribosomal biogenesis factor OS=Homo sapiens OX=9606 GN=RBIS PE=1 SV=4" "0.007" "False" "2.412" "9" "1" "1" "1" "100" "11.4" "10.46" "2.30" "1" "other biological processes" "cytosol;nucleus" "" "Pf15679" "401466" "ENSG00000176731" "RBIS" "B2RXE7; E5RFW5; hsa:401466; Q8N0T1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-726538263945454181" "False" "High" "IsMasterProtein" "Q01459" "Di-N-acetylchitobiase OS=Homo sapiens OX=9606 GN=CTBS PE=1 SV=1" "0.007" "False" "2.411" "2" "1" "1" "1" "385" "43.7" "6.64" "2.16" "1" "other metabolic processes" "other cytoplasmic organelle" "other molecular function" "Pf00704" "1486" "ENSG00000117151" "CTBS" "hsa:1486; Q01459; Q5VX50" "" "" "0" "0" "1.152" "1.050" "1.223" "1.169" "0.893" "1.228" "1.279" "1.158" "0.690" "23.1" "26.6" "24.2" "28.2" "27.0" "20.6" "28.3" "29.5" "26.7" "15.9" "" "" "" "" "" "" "" "" "" "" "13.8" "13.8" "13.4" "13.3" "12.5" "10.5" "13.2" "13.3" "14.5" "15.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-374289036912732411" "False" "High" "IsMasterProtein" "Q15042" "Rab3 GTPase-activating protein catalytic subunit OS=Homo sapiens OX=9606 GN=RAB3GAP1 PE=1 SV=3" "0.007" "False" "2.409" "1" "1" "1" "1" "981" "110.5" "5.55" "0.00" "1" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf13890, Pf19533" "22930" "ENSG00000115839" "RAB3GAP1" "A6H8Z3; C9J837; hsa:22930; Q15042; Q659F5; Q8TBB4" "" "RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9074819377594512916" "False" "High" "IsMasterProtein" "Q9BQ67" "Glutamate-rich WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GRWD1 PE=1 SV=1" "0.007" "False" "2.409" "2" "1" "1" "1" "446" "49.4" "4.92" "2.85" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "83743" "ENSG00000105447" "GRWD1" "A0MNN5; hsa:83743; Q8TF59; Q9BQ67" "" "" "0" "0" "1.177" "1.003" "0.947" "1.130" "1.117" "1.016" "0.811" "1.049" "5.047" "59.1" "69.6" "59.3" "56.0" "66.8" "66.1" "60.1" "48.0" "62.0" "298.5" "" "" "" "" "" "" "" "" "" "" "35.4" "36.2" "32.8" "26.3" "31.0" "33.8" "27.9" "21.5" "33.6" "298.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1329067276742603011" "False" "High" "IsMasterProtein" "Q8WYP5" "Protein ELYS OS=Homo sapiens OX=9606 GN=AHCTF1 PE=1 SV=3" "0.007" "False" "2.407" "1" "1" "1" "1" "2266" "252.3" "6.60" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf13934, Pf16687" "25909" "ENSG00000153207" "AHCTF1" "A6NGM0; A8MSG9; A8MZ86; hsa:25909; Q7Z4E3; Q8IZA4; Q8WYP5; Q96EH9; Q9Y4Q6" "Gastric cancer network 2" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1837878793854205649" "False" "High" "IsMasterProtein" "Q9BVL2" "Nucleoporin p58/p45 OS=Homo sapiens OX=9606 GN=NUP58 PE=1 SV=1" "0.007" "False" "2.402" "1" "1" "1" "1" "599" "60.9" "9.33" "2.41" "1" "transport;other biological processes" "other membranes;nucleus" "other molecular function" "Pf15967" "9818" "ENSG00000139496" "NUP58" "A6NI12; B4DZJ1; hsa:9818; O43160; Q5JRG2; Q5JRG5; Q9BVL2" "" "" "0" "0" "0.928" "0.918" "0.878" "1.141" "0.975" "0.989" "1.161" "0.969" "1.128" "44.7" "41.5" "41.1" "39.3" "51.0" "43.6" "44.2" "51.9" "43.3" "50.4" "" "" "" "" "" "" "" "" "" "" "26.8" "21.6" "22.7" "18.4" "23.6" "22.3" "20.6" "23.3" "23.5" "50.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7463522735319849849" "False" "High" "IsMasterProtein" "O15031" "Plexin-B2 OS=Homo sapiens OX=9606 GN=PLXNB2 PE=1 SV=3" "0.007" "False" "2.402" "1" "1" "1" "1" "1838" "205.0" "6.24" "0.00" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf01403, Pf01437, Pf01833, Pf08337, Pf17960, Pf20170" "23654" "ENSG00000196576" "PLXNB2" "A6QRH0; hsa:23654; O15031; Q7KZU3; Q9BSU7" "2q11.2 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3066040936717898467" "False" "High" "IsMasterProtein" "Q8NC60" "Nitric oxide-associated protein 1 OS=Homo sapiens OX=9606 GN=NOA1 PE=1 SV=2" "0.007" "False" "2.401" "3" "1" "1" "1" "698" "78.4" "8.66" "0.00" "1" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf01926, Pf21516" "84273" "ENSG00000084092" "NOA1" "hsa:84273; Q8N7L6; Q8NC60; Q9BSQ9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "High" "Not Found" "Not Found" "High" "Not Found" "High" "High" "High" "1" "" "6594093010420554285" "False" "High" "IsMasterProtein" "Q9NWZ3" "Interleukin-1 receptor-associated kinase 4 OS=Homo sapiens OX=9606 GN=IRAK4 PE=1 SV=1" "0.007" "False" "2.396" "2" "1" "2" "1" "460" "51.5" "5.41" "4.78" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf07714" "51135" "ENSG00000198001" "IRAK4" "hsa:51135; Q69FE1; Q8TDF7; Q9NWZ3; Q9Y589" "IL-1 signaling pathway; AGE/RAGE pathway; Interleukin-1 (IL-1) structural pathway; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Fibrin complement receptor 3 signaling pathway; miRNA role in immune response in sepsis; LTF danger signal response pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Toll-like receptor signaling pathway" "Interleukin-1 signaling; PIP3 activates AKT signaling; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; IRAK4 deficiency (TLR2/4); PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; MyD88 cascade initiated on plasma membrane; IRAK4 deficiency (TLR5); TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "23" "0" "0.950" "1.061" "0.915" "1.344" "1.066" "0.999" "0.732" "1.063" "4.403" "50.2" "47.7" "53.3" "46.0" "67.6" "53.6" "50.2" "36.8" "53.4" "221.3" "" "" "" "" "" "" "" "" "" "" "30.1" "24.8" "29.5" "21.6" "31.3" "27.4" "23.4" "16.5" "29.0" "221.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6548984541792378367" "False" "High" "IsMasterProtein" "Q9Y5Y2" "Cytosolic Fe-S cluster assembly factor NUBP2 OS=Homo sapiens OX=9606 GN=NUBP2 PE=1 SV=1" "0.007" "False" "2.396" "4" "1" "1" "1" "271" "28.8" "5.83" "1.89" "1" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10609" "10101" "ENSG00000095906" "NUBP2" "D3DU80; hsa:10101; Q9NWB2; Q9Y5Y2" "Iron-sulfur cluster biogenesis" "Cytosolic iron-sulfur cluster assembly" "2" "0" "0.625" "0.527" "0.800" "0.914" "0.702" "0.772" "0.891" "0.738" "0.639" "28.9" "18.1" "15.2" "23.1" "26.5" "20.3" "22.3" "25.8" "21.3" "18.5" "" "" "" "" "" "" "" "" "" "" "17.3" "9.4" "8.4" "10.9" "12.3" "10.4" "10.4" "11.6" "11.6" "18.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2424139350801194209" "False" "High" "IsMasterProtein" "Q9NRG0" "Chromatin accessibility complex protein 1 OS=Homo sapiens OX=9606 GN=CHRAC1 PE=1 SV=1" "0.008" "False" "2.393" "6" "1" "8" "1" "131" "14.7" "5.10" "12.88" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "54108" "ENSG00000104472" "CHRAC1" "hsa:54108; Q9NRG0" "Acute viral myocarditis" "" "1" "0" "1.060" "1.069" "1.251" "1.333" "1.233" "1.105" "1.172" "1.054" "1.447" "265.4" "281.3" "283.7" "331.8" "353.8" "327.1" "293.3" "311.1" "279.8" "383.9" "" "" "" "" "" "" "" "" "" "" "158.8" "146.2" "157.1" "155.8" "164.0" "167.5" "136.4" "139.7" "151.8" "383.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3793795971274937654" "False" "High" "IsMasterProtein" "Q96S59" "Ran-binding protein 9 OS=Homo sapiens OX=9606 GN=RANBP9 PE=1 SV=1" "0.008" "False" "2.388" "1" "1" "1" "1" "729" "77.8" "6.79" "0.00" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00622, Pf08513, Pf10607" "10048" "ENSG00000010017" "RANBP9" "A0PJA2; B2R8E1; hsa:10048; O94764; Q6P3T7; Q7LBR2; Q7Z7F9; Q96S59" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Ciliary landscape" "RAF/MAP kinase cascade; L1CAM interactions; MET activates RAS signaling" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4962513167934133051" "False" "High" "IsMasterProtein" "P49643" "DNA primase large subunit OS=Homo sapiens OX=9606 GN=PRIM2 PE=1 SV=2" "0.008" "False" "2.386" "2" "1" "1" "1" "509" "58.8" "7.91" "1.94" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf04104" "5558" "ENSG00000146143" "PRIM2" "hsa:5558; P49643; Q53FJ8; Q6P1Q7; Q8WVL2; Q9H413" "Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "Activation of the pre-replicative complex; Defective pyroptosis; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate" "12" "0" "1.342" "1.161" "1.608" "1.351" "1.197" "1.410" "0.533" "1.282" "6.650" "15.4" "20.7" "17.9" "24.8" "20.9" "18.5" "21.8" "8.2" "19.8" "102.7" "" "" "" "" "" "" "" "" "" "" "9.2" "10.8" "9.9" "11.7" "9.7" "9.5" "10.1" "3.7" "10.7" "102.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7892185460647837485" "False" "High" "IsMasterProtein" "Q53RE8" "Ankyrin repeat domain-containing protein 39 OS=Homo sapiens OX=9606 GN=ANKRD39 PE=1 SV=1" "0.008" "False" "2.386" "6" "1" "1" "1" "183" "19.6" "6.89" "0.00" "1" "" "" "" "Pf12796" "51239" "ENSG00000213337" "ANKRD39" "hsa:51239; Q53RE8; Q59FU2; Q8N5X5; Q9P0S5" "2q11.2 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1042758646776431623" "False" "High" "IsMasterProtein" "Q9UQR0" "Sex comb on midleg-like protein 2 OS=Homo sapiens OX=9606 GN=SCML2 PE=1 SV=1" "0.008" "False" "2.382" "2" "1" "1" "1" "700" "77.2" "8.54" "1.73" "1" "other biological processes" "nucleus" "other molecular function" "Pf00536, Pf02820, Pf12140, Pf17208" "10389" "ENSG00000102098" "SCML2" "hsa:10389; Q5JXE6; Q86U98; Q8IWD0; Q8NDP2; Q9UGC5; Q9UQR0" "" "" "0" "0" "0.972" "1.832" "0.779" "1.698" "1.150" "1.026" "1.163" "1.162" "4.932" "13.8" "13.5" "25.4" "10.8" "23.5" "15.9" "14.2" "16.1" "16.1" "68.3" "" "" "" "" "" "" "" "" "" "" "8.3" "7.0" "14.1" "5.1" "10.9" "8.2" "6.6" "7.2" "8.7" "68.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8619075754329803082" "False" "High" "IsMasterProtein" "P17275" "Transcription factor JunB OS=Homo sapiens OX=9606 GN=JUNB PE=1 SV=1" "0.008" "False" "2.377" "3" "1" "1" "1" "347" "35.9" "9.22" "2.22" "1" "cell cycle OR cell proliferation;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf03957" "3726" "ENSG00000171223" "JUNB" "hsa:3726; P17275; Q96GH3" "Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Photodynamic therapy-induced AP-1 survival signaling; IL6 signaling pathway; TGF-beta signaling pathway; Oxidative stress response; Host-pathogen interaction of human coronaviruses - MAPK signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Orexin receptor pathway; Osteoarthritic chondrocyte hypertrophy" "NGF-stimulated transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Interleukin-4 and Interleukin-13 signaling; Nuclear events stimulated by ALK signaling in cancer" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6229866583710047273" "False" "High" "IsMasterProtein" "Q96C23" "Galactose mutarotase OS=Homo sapiens OX=9606 GN=GALM PE=1 SV=1" "0.008" "False" "2.367" "3" "1" "1" "1" "342" "37.7" "6.65" "2.14" "1" "other metabolic processes" "other cell component" "other molecular function" "Pf01263" "130589" "ENSG00000143891" "GALM" "hsa:130589; Q53RY1; Q8NIA2; Q96C23; V9HWA8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4792290450889044309" "False" "High" "IsMasterProtein" "Q96IV0" "Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Homo sapiens OX=9606 GN=NGLY1 PE=1 SV=1" "0.008" "False" "2.361" "1" "1" "1" "1" "654" "74.3" "6.89" "2.54" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01841, Pf04721, Pf09409" "55768" "ENSG00000151092" "NGLY1" "B4DJE9; hsa:55768; Q59FB1; Q6PJD8; Q96IV0; Q9BVR8; Q9NR70" "" "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "Not Found" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6769080269671987288" "False" "High" "IsMasterProtein" "Q9NVP1" "ATP-dependent RNA helicase DDX18 OS=Homo sapiens OX=9606 GN=DDX18 PE=1 SV=2" "0.008" "False" "2.360" "1" "1" "1" "1" "670" "75.4" "9.50" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf13959" "8886" "ENSG00000088205" "DDX18" "hsa:8886; Q6GTZ9; Q6IAU4; Q92732; Q9BQB7; Q9NVP1" "" "" "0" "0" "1.510" "1.399" "0.644" "0.944" "1.470" "1.204" "0.983" "0.718" "2.576" "15.1" "22.8" "21.1" "9.7" "14.3" "22.2" "18.2" "14.8" "10.8" "38.9" "" "" "" "" "" "" "" "" "" "" "9.0" "11.8" "11.7" "4.6" "6.6" "11.4" "8.4" "6.7" "5.9" "38.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9193624318579361527" "False" "High" "IsMasterProtein" "Q9UGI8" "Testin OS=Homo sapiens OX=9606 GN=TES PE=1 SV=1" "0.008" "False" "2.359" "2" "1" "1" "1" "421" "48.0" "7.68" "2.72" "1" "other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00412, Pf06297" "26136" "ENSG00000135269" "TES" "A4D0U6; hsa:26136; Q9GZQ1; Q9HAJ9; Q9UGI8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-569299239056590327" "False" "High" "IsMasterProtein" "Q9Y4F9" "Rho family-interacting cell polarization regulator 2 OS=Homo sapiens OX=9606 GN=RIPOR2 PE=1 SV=4" "0.008" "False" "2.347" "1" "1" "1" "1" "1068" "118.4" "5.41" "2.99" "1" "cell adhesion;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf15903" "9750" "ENSG00000111913" "RIPOR2" "A6NHP2; hsa:9750; Q13529; Q5VV37; Q5VV38; Q9BQ28; Q9Y4F9" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2811612656550812332" "False" "High" "IsMasterProtein" "O75019" "Leukocyte immunoglobulin-like receptor subfamily A member 1 OS=Homo sapiens OX=9606 GN=LILRA1 PE=1 SV=1" "0.008" "False" "2.347" "2" "1" "1" "1" "489" "53.2" "7.84" "1.96" "1" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf13895, Pf13927" "11024" "ENSG00000104974; ENSG00000274935; ENSG00000275525; ENSG00000277398" "LILRA1" "hsa:11024; O75018; O75019; Q3MJA6" "" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" "1" "0" "1.338" "0.923" "1.282" "2.167" "1.248" "1.434" "1.480" "1.305" "1.790" "19.8" "26.5" "18.3" "25.4" "42.9" "24.7" "28.4" "29.3" "25.8" "35.4" "" "" "" "" "" "" "" "" "" "" "11.9" "13.8" "10.1" "11.9" "19.9" "12.7" "13.2" "13.2" "14.0" "35.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4327969175985067622" "False" "High" "IsMasterProtein" "Q6I9Y2" "THO complex subunit 7 homolog OS=Homo sapiens OX=9606 GN=THOC7 PE=1 SV=3" "0.008" "False" "2.346" "6" "1" "1" "1" "204" "23.7" "5.67" "2.19" "1" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05615" "80145" "ENSG00000163634" "THOC7" "hsa:80145; Q6I9Y2; Q6P1L3; Q8WUF2; Q9H5H0" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8260092317082084293" "False" "High" "IsMasterProtein" "Q13362" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform OS=Homo sapiens OX=9606 GN=PPP2R5C PE=1 SV=3" "0.008" "False" "2.346" "2" "1" "2" "1" "524" "61.0" "6.87" "2.21" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf01603" "5527" "ENSG00000078304" "PPP2R5C" "B4DYJ8; B5BUA5; F5GWP3; hsa:5527; Q13362; Q14391; Q15060; Q15174; Q6ZN33" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; DNA damage response (only ATM dependent)" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; RAF activation; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling" "29" "0" "0.920" "1.252" "1.273" "1.033" "1.270" "1.100" "1.092" "1.031" "2.365" "25.4" "23.4" "31.8" "32.3" "26.2" "32.2" "27.9" "27.7" "26.2" "60.0" "" "" "" "" "" "" "" "" "" "" "15.2" "12.1" "17.6" "15.2" "12.2" "16.5" "13.0" "12.4" "14.2" "60.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4123477520333659496" "False" "High" "IsMasterProtein" "Q7Z4G4" "tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens OX=9606 GN=TRMT11 PE=1 SV=1" "0.008" "False" "2.342" "2" "1" "3" "1" "463" "53.4" "7.78" "7.64" "1" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "nucleic acid binding activity" "Pf01170" "60487" "ENSG00000066651" "TRMT11" "E1P570; hsa:60487; Q5JY11; Q6PGQ5; Q7Z4G4; Q9HC13" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.989" "0.973" "1.019" "1.043" "1.123" "1.008" "1.106" "1.039" "0.794" "432.7" "427.9" "421.2" "441.0" "451.4" "485.7" "436.1" "478.5" "449.6" "343.7" "" "" "" "" "" "" "" "" "" "" "258.9" "222.4" "233.2" "207.0" "209.2" "248.7" "202.8" "214.8" "243.9" "343.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8588512168019091393" "False" "High" "IsMasterProtein" "Q5FWF5" "N-acetyltransferase ESCO1 OS=Homo sapiens OX=9606 GN=ESCO1 PE=1 SV=3" "0.008" "False" "2.327" "1" "1" "1" "1" "840" "94.9" "9.16" "2.81" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13878, Pf13880" "114799" "ENSG00000141446" "ESCO1" "B0YJ11; B0YJ12; hsa:114799; Q5FWF5; Q69YG4; Q69YS3; Q6IMD7; Q8N3Z5; Q8NBG2; Q96PX7" "Cohesin complex - Cornelia de Lange syndrome" "Establishment of Sister Chromatid Cohesion" "2" "0" "1.266" "0.897" "1.023" "1.262" "0.977" "1.199" "1.136" "1.036" "1.123" "65.6" "83.1" "58.9" "67.1" "82.8" "64.1" "78.6" "74.5" "67.9" "73.6" "" "" "" "" "" "" "" "" "" "" "39.3" "43.2" "32.6" "31.5" "38.4" "32.8" "36.6" "33.4" "36.9" "73.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6438294564185077030" "False" "High" "IsMasterProtein" "Q9BPW8" "Protein NipSnap homolog 1 OS=Homo sapiens OX=9606 GN=NIPSNAP1 PE=1 SV=1" "0.008" "False" "2.323" "3" "1" "1" "1" "284" "33.3" "9.31" "2.11" "1" "other biological processes" "plasma membrane;other membranes;mitochondrion" "" "Pf07978" "8508" "ENSG00000184117" "NIPSNAP1" "B2RAY3; hsa:8508; O43800; Q9BPW8" "" "" "0" "0" "1.018" "0.831" "1.064" "0.971" "0.994" "0.941" "1.189" "0.762" "0.725" "63.7" "64.8" "52.9" "67.7" "61.9" "63.3" "59.9" "75.7" "48.5" "46.2" "" "" "" "" "" "" "" "" "" "" "38.1" "33.7" "29.3" "31.8" "28.7" "32.4" "27.9" "34.0" "26.3" "46.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7917759671781486439" "False" "High" "IsMasterProtein" "Q13627" "Dual specificity tyrosine-phosphorylation-regulated kinase 1A OS=Homo sapiens OX=9606 GN=DYRK1A PE=1 SV=2" "0.008" "False" "2.315" "2" "1" "1" "1" "763" "85.5" "8.75" "2.03" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "1859" "ENSG00000157540" "DYRK1A" "hsa:1859; O60769; Q13627; Q92582; Q92810; Q9UNM5" "T cell receptor and co-stimulatory signaling; DYRK1A involvement regarding cell proliferation in brain development" "G0 and Early G1" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4879216047058048587" "False" "High" "IsMasterProtein" "P81605" "Dermcidin OS=Homo sapiens OX=9606 GN=DCD PE=1 SV=2" "0.008" "False" "2.314" "6" "1" "2" "1" "110" "11.3" "6.54" "4.03" "1" "protein metabolism;stress response;transport" "non-structural extracellular;other membranes" "transporter activity;other molecular function" "Pf15291" "117159" "ENSG00000161634" "DCD" "A5JHP2; A5JHP3; hsa:117159; P58461; P81605; Q53YJ2" "" "Antimicrobial peptides" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4826507384630182713" "False" "High" "IsMasterProtein" "Q96IZ7" "Serine/Arginine-related protein 53 OS=Homo sapiens OX=9606 GN=RSRC1 PE=1 SV=1" "0.008" "False" "2.312" "2" "1" "1" "1" "334" "38.7" "11.08" "2.70" "1" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "" "" "51319" "ENSG00000174891" "RSRC1" "A8K2R9; hsa:51319; Q96IZ7; Q96QK2; Q9NZE5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3605806557374244366" "False" "High" "IsMasterProtein" "Q99766" "ATP synthase subunit s, mitochondrial OS=Homo sapiens OX=9606 GN=DMAC2L PE=1 SV=4" "0.008" "False" "2.307" "6" "1" "1" "1" "200" "23.2" "7.90" "1.75" "1" "other metabolic processes;transport" "other membranes;mitochondrion;other cell component" "transporter activity;other molecular function" "" "27109" "ENSG00000125375" "DMAC2L" "A0A2R8YDJ1; A0A5K1VW60; A8K1U3; D9N156; hsa:27109; Q8WWX3; Q96F77; Q99766" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "Cristae formation; Formation of ATP by chemiosmotic coupling" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7340986186018177511" "False" "High" "IsMasterProtein" "P05496" "ATP synthase F(0) complex subunit C1, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5MC1 PE=1 SV=2" "0.009" "False" "2.303" "5" "1" "1" "1" "136" "14.3" "9.74" "3.21" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00137" "516" "ENSG00000159199" "ATP5MC1" "hsa:516; P05496" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Mitochondrial protein import; Cristae formation; Formation of ATP by chemiosmotic coupling" "6" "0" "0.852" "1.062" "0.967" "0.989" "1.120" "0.877" "1.050" "1.071" "1.030" "198.0" "168.7" "210.2" "191.4" "195.7" "221.7" "173.7" "207.9" "212.0" "203.9" "" "" "" "" "" "" "" "" "" "" "118.5" "87.7" "116.4" "89.8" "90.7" "113.5" "80.7" "93.4" "115.0" "203.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1768771022967141070" "False" "High" "IsMasterProtein" "Q9Y4H4" "G-protein-signaling modulator 3 OS=Homo sapiens OX=9606 GN=GPSM3 PE=1 SV=1" "0.009" "False" "2.300" "14" "1" "1" "1" "160" "17.9" "4.97" "0.00" "1" "other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity" "Pf02188" "63940" "ENSG00000206314; ENSG00000213654; ENSG00000233490; ENSG00000234243; ENSG00000234508; ENSG00000236697; ENSG00000237052" "GPSM3" "A2BFJ3; hsa:63940; Q9Y4H4" "" "G alpha (i) signalling events" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "Not Found" "High" "High" "High" "High" "High" "Not Found" "High" "1" "" "-3114366665604462397" "False" "High" "IsMasterProtein" "Q9BZE2" "tRNA pseudouridine(38/39) synthase OS=Homo sapiens OX=9606 GN=PUS3 PE=1 SV=3" "0.009" "False" "2.297" "2" "1" "1" "1" "481" "55.6" "7.49" "1.70" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01416" "83480" "ENSG00000110060" "PUS3" "B2RAM0; hsa:83480; Q96D17; Q96J23; Q96NB4; Q9BZE2" "" "tRNA modification in the nucleus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-996241339141020167" "False" "High" "IsMasterProtein" "Q96SB8" "Structural maintenance of chromosomes protein 6 OS=Homo sapiens OX=9606 GN=SMC6 PE=1 SV=2" "0.009" "False" "2.294" "1" "1" "1" "1" "1091" "126.2" "6.99" "2.12" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13476" "79677" "ENSG00000163029" "SMC6" "A8K8Q6; D6W518; hsa:79677; Q05BV4; Q96SB8; Q9H0X3; Q9H6M0" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "1.210" "1.483" "2.207" "1.428" "1.392" "1.119" "1.290" "1.743" "8.794" "8.3" "10.1" "12.4" "18.4" "11.9" "11.6" "9.3" "10.8" "14.5" "73.4" "" "" "" "" "" "" "" "" "" "" "5.0" "5.2" "6.9" "8.6" "5.5" "5.9" "4.3" "4.8" "7.9" "73.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4235528814650407609" "False" "High" "IsMasterProtein" "Q96DT6" "Cysteine protease ATG4C OS=Homo sapiens OX=9606 GN=ATG4C PE=1 SV=1" "0.009" "False" "2.288" "2" "1" "1" "1" "458" "52.5" "5.97" "1.82" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "other cell component" "other molecular function" "Pf03416, Pf20166" "84938" "ENSG00000125703" "ATG4C" "A6NLR8; D3DQ58; hsa:84938; Q96DT6; Q96K04" "Clock-controlled autophagy in bone metabolism" "Macroautophagy" "2" "0" "1.288" "0.981" "1.206" "1.222" "0.948" "0.897" "0.800" "1.044" "2.463" "25.7" "33.1" "25.2" "31.0" "31.4" "24.4" "23.1" "20.6" "26.8" "63.3" "" "" "" "" "" "" "" "" "" "" "15.4" "17.2" "14.0" "14.6" "14.6" "12.5" "10.7" "9.2" "14.6" "63.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4968943538571685199" "False" "High" "IsMasterProtein" "Q96GC5" "Large ribosomal subunit protein mL48 OS=Homo sapiens OX=9606 GN=MRPL48 PE=1 SV=2" "0.009" "False" "2.287" "4" "1" "1" "1" "212" "23.9" "8.98" "2.48" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf00338" "51642" "ENSG00000175581" "MRPL48" "B4DN34; hsa:51642; Q49AK7; Q4U2Q4; Q96GC5; Q9P091; Q9Y5J0" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824590419555307181" "False" "High" "IsMasterProtein" "P63165" "Small ubiquitin-related modifier 1 OS=Homo sapiens OX=9606 GN=SUMO1 PE=1 SV=1" "0.009" "False" "2.284" "7" "1" "8" "1" "101" "11.6" "5.52" "22.01" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf11976" "7341" "ENSG00000116030" "SUMO1" "A8MUS8; B2R4I5; hsa:7341; P55856; P63165; Q6FGG0; Q6NZ62; Q93068" "Androgen receptor signaling pathway; TP53 network; TGF-beta signaling pathway; Exercise-induced circadian regulation" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of IFNG signaling; SUMOylation of DNA damage response and repair proteins; Formation of Incision Complex in GG-NER; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; PKR-mediated signaling; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; SUMOylation of nuclear envelope proteins; Maturation of nucleoprotein; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "27" "0" "0.995" "1.066" "1.004" "1.069" "0.933" "1.128" "0.886" "0.944" "1.624" "571.6" "569.0" "609.1" "573.8" "611.3" "533.3" "645.0" "506.4" "539.4" "928.5" "" "" "" "" "" "" "" "" "" "" "342.1" "295.7" "337.3" "269.4" "283.3" "273.0" "299.9" "227.3" "292.7" "928.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-832675095304565644" "False" "High" "IsMasterProtein" "Q8IY26" "Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 OS=Homo sapiens OX=9606 GN=PLPP6 PE=1 SV=3" "0.009" "False" "2.282" "3" "1" "1" "1" "295" "32.2" "9.99" "1.72" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus" "other molecular function" "Pf01569" "403313" "ENSG00000205808" "PLPP6" "B3KY05; hsa:403313; Q5JVJ6; Q8IY26; Q8NCK9" "" "Cholesterol biosynthesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8545546198445454404" "False" "High" "IsMasterProtein" "E5RHQ5" "Nuclear pore complex-interacting protein family member B11 OS=Homo sapiens OX=9606 GN=NPIPB11 PE=3 SV=1" "0.009" "False" "2.277" "1" "1" "1" "1" "1161" "129.1" "10.04" "2.67" "1" "" "other membranes" "" "Pf06409, Pf20885" "" "ENSG00000254206" "NPIPB11" "E5RHQ5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2331175161516182807" "False" "High" "IsMasterProtein" "Q6YN16" "Hydroxysteroid dehydrogenase-like protein 2 OS=Homo sapiens OX=9606 GN=HSDL2 PE=1 SV=1" "0.009" "False" "2.275" "2" "1" "1" "1" "418" "45.4" "7.99" "2.38" "1" "" "mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00106, Pf02036" "84263" "ENSG00000119471" "HSDL2" "A8K1L4; A8K8X1; A8MSV3; hsa:84263; Q658M8; Q6YN16; Q9BT58" "" "" "0" "0" "1.836" "1.436" "1.669" "1.319" "1.843" "1.333" "1.588" "1.819" "3.408" "32.3" "59.3" "46.4" "53.9" "42.6" "59.6" "43.1" "51.3" "58.8" "110.1" "" "" "" "" "" "" "" "" "" "" "19.3" "30.8" "25.7" "25.3" "19.8" "30.5" "20.0" "23.0" "31.9" "110.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1141936988023863748" "False" "High" "IsMasterProtein" "Q9NP61" "ADP-ribosylation factor GTPase-activating protein 3 OS=Homo sapiens OX=9606 GN=ARFGAP3 PE=1 SV=1" "0.009" "False" "2.273" "2" "1" "1" "1" "516" "56.9" "7.36" "0.00" "1" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf01412" "26286" "ENSG00000242247" "ARFGAP3" "E9PB03; hsa:26286; Q9BSC6; Q9H9J0; Q9NP61; Q9NT10; Q9NUP5; Q9Y4V3; Q9Y4V4" "Ciliary landscape" "COPI-mediated anterograde transport; CDC42 GTPase cycle; RHOG GTPase cycle; COPI-dependent Golgi-to-ER retrograde traffic" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2002470481848011023" "False" "High" "IsMasterProtein" "Q9P032" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 OS=Homo sapiens OX=9606 GN=NDUFAF4 PE=1 SV=1" "0.009" "False" "2.272" "5" "1" "1" "1" "175" "20.3" "8.82" "2.41" "1" "cell organization and biogenesis;stress response;other biological processes" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf06784" "29078" "ENSG00000123545" "NDUFAF4" "B2R4J5; hsa:29078; Q9P032" "" "Complex I biogenesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2766829585988969351" "False" "High" "IsMasterProtein" "O75190" "DnaJ homolog subfamily B member 6 OS=Homo sapiens OX=9606 GN=DNAJB6 PE=1 SV=2" "0.009" "False" "2.272" "2" "1" "1" "1" "326" "36.1" "9.16" "2.16" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00226" "10049" "ENSG00000105993" "DNAJB6" "A4D232; A8K7D8; A8KAG0; B4DN73; E9PCZ2; hsa:10049; O75190; O95806; Q53EN8; Q59EF2; Q6FIC8; Q75MA2; Q9UIK6" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "935705506060532462" "False" "High" "IsMasterProtein" "A0A0U1RRE5" "Negative regulator of P-body association OS=Homo sapiens OX=9606 GN=NBDY PE=1 SV=1" "0.009" "False" "2.269" "13" "1" "5" "1" "68" "7.0" "9.42" "4.80" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "" "" "550643" "ENSG00000204272" "NBDY" "A0A0U1RRE5" "" "" "0" "0" "1.080" "0.991" "1.120" "1.233" "1.281" "1.108" "1.355" "0.906" "0.682" "103.2" "111.5" "102.3" "115.6" "127.3" "132.2" "114.3" "139.8" "93.5" "70.4" "" "" "" "" "" "" "" "" "" "" "61.8" "57.9" "56.7" "54.3" "59.0" "67.7" "53.2" "62.8" "50.7" "70.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3715797868298302435" "False" "High" "IsMasterProtein" "Q5ST30" "Valine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=VARS2 PE=1 SV=2" "0.009" "False" "2.266" "1" "1" "1" "1" "1063" "118.4" "7.02" "2.10" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00133, Pf08264" "57176" "ENSG00000137411; ENSG00000223494" "VARS2" "A2ABL7; B4DET4; B4E3P5; F5GXJ0; F5H323; hsa:57176; Q2M2A0; Q59FI1; Q5SQ96; Q5SS98; Q5ST30; Q6DKJ5; Q6ZV24; Q96GN2; Q96H77; Q96Q02; Q9H6R2; Q9UFH7" "" "Mitochondrial tRNA aminoacylation" "1" "0" "0.973" "1.423" "1.191" "1.200" "1.384" "1.189" "0.876" "1.301" "1.708" "37.8" "36.8" "53.8" "45.0" "45.4" "52.3" "45.0" "33.1" "49.2" "64.6" "" "" "" "" "" "" "" "" "" "" "22.6" "19.1" "29.8" "21.1" "21.0" "26.8" "20.9" "14.9" "26.7" "64.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5687850324260335343" "False" "High" "IsMasterProtein" "Q16875" "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 OS=Homo sapiens OX=9606 GN=PFKFB3 PE=1 SV=1" "0.009" "False" "2.264" "2" "1" "1" "1" "520" "59.6" "8.21" "2.03" "1" "other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00300, Pf01591" "5209" "ENSG00000170525" "PFKFB3" "B7Z955; hsa:5209; O43622; O75902; Q16875; Q5VX15; Q5VX18; Q5VX19" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8004592446864816783" "False" "High" "IsMasterProtein" "O75688" "Protein phosphatase 1B OS=Homo sapiens OX=9606 GN=PPM1B PE=1 SV=1" "0.009" "False" "2.264" "2" "1" "1" "1" "479" "52.6" "5.05" "2.03" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf00481, Pf07830" "5495" "ENSG00000138032" "PPM1B" "hsa:5495; O75688; Q461Q2; Q4J6C1; Q4J6C2; Q658R4; Q96ER6; Q9HAY8" "MAPK signaling pathway" "ISG15 antiviral mechanism; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-293732230676877255" "False" "High" "IsMasterProtein" "P01909" "HLA class II histocompatibility antigen, DQ alpha 1 chain OS=Homo sapiens OX=9606 GN=HLA-DQA1 PE=1 SV=1" "0.009" "False" "2.261" "3" "1" "2" "1" "254" "27.8" "5.72" "5.38" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00993, Pf07654" "3117" "ENSG00000196735; ENSG00000206305; ENSG00000232062" "HLA-DQA1" "hsa:3117; O19630; O19706; P01907; P01908; P01909; P04225; P04226; P05536; P79553; Q06751; Q29876; Q29994; Q2Q6Y6; Q2Q6Y7; Q2Q6Y8; Q2WCM3; Q30064; Q30067; Q30068; Q30070; Q30071; Q30072; Q30073; Q30086; Q30101; Q5Y7D5; Q5Y7F5; Q6ICU6; Q6PR46; Q6QDB1; Q860W2; Q860W4; Q9BD37; Q9TPM3; Q9UM31" "Allograft rejection; Vitamin D receptor pathway; Ebola virus infection in host" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "10" "0" "1.166" "1.060" "1.065" "1.136" "0.985" "1.248" "1.326" "1.158" "0.501" "193.2" "225.3" "204.8" "205.7" "219.4" "190.2" "241.0" "256.2" "223.7" "96.8" "" "" "" "" "" "" "" "" "" "" "115.6" "117.1" "113.4" "96.6" "101.7" "97.4" "112.1" "115.0" "121.4" "96.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-749856808040687854" "False" "High" "IsMasterProtein" "Q8WTS6" "Histone-lysine N-methyltransferase SETD7 OS=Homo sapiens OX=9606 GN=SETD7 PE=1 SV=1" "0.009" "False" "2.259" "2" "1" "1" "1" "366" "40.7" "4.63" "2.51" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00856, Pf02493" "80854" "ENSG00000145391" "SETD7" "B5WWL3; hsa:80854; Q0VAH3; Q4W5A9; Q8WTS6; Q9C0E6" "Histone modifications" "PKMTs methylate histone lysines" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6960359147395003723" "False" "High" "IsMasterProtein" "P15498" "Proto-oncogene vav OS=Homo sapiens OX=9606 GN=VAV1 PE=1 SV=4" "0.009" "False" "2.252" "1" "1" "1" "1" "845" "98.3" "6.62" "2.36" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00017, Pf00018, Pf00130, Pf00169, Pf00307, Pf00621" "7409" "ENSG00000141968" "VAV1" "B4DVK9; hsa:7409; M0QXX6; P15498; Q15860" "Prolactin signaling pathway; B cell receptor signaling pathway; Hematopoietic stem cell differentiation; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL6 signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; EGF/EGFR signaling pathway; Modulators of TCR signaling and T cell activation; Regulation of actin cytoskeleton; Interferon type I signaling pathways; T-cell receptor signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; RHOA GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; Signaling by SCF-KIT; Azathioprine ADME; VEGFR2 mediated vascular permeability; Erythropoietin activates RAS; CD28 dependent Vav1 pathway" "38" "0" "0.951" "1.248" "1.248" "1.193" "1.218" "1.005" "0.986" "1.031" "5.282" "58.8" "55.9" "73.4" "73.3" "70.1" "71.6" "59.0" "58.0" "60.6" "310.4" "" "" "" "" "" "" "" "" "" "" "35.2" "29.0" "40.6" "34.4" "32.5" "36.7" "27.5" "26.0" "32.9" "310.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-348929784632102448" "False" "High" "IsMasterProtein" "O75306" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS2 PE=1 SV=2" "0.009" "False" "2.248" "2" "1" "1" "1" "463" "52.5" "7.55" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;mitochondrion;nucleus" "transporter activity;other molecular function" "Pf00346" "4720" "ENSG00000158864" "NDUFS2" "D3DVG7; hsa:4720; J3KPM7; O75306; Q5VTW0; Q969P3; Q9UEV3" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "718795190937465911" "False" "High" "IsMasterProtein" "Q9Y6V7" "Probable ATP-dependent RNA helicase DDX49 OS=Homo sapiens OX=9606 GN=DDX49 PE=1 SV=1" "0.009" "False" "2.240" "2" "1" "1" "1" "483" "54.2" "9.06" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00270, Pf00271" "54555" "ENSG00000105671" "DDX49" "E7ENA0; hsa:54555; Q53FJ1; Q9BVQ8; Q9Y6V7" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.901" "1.103" "1.447" "1.024" "1.134" "1.065" "1.336" "0.812" "1.003" "26.6" "24.0" "29.4" "38.5" "27.2" "30.2" "28.3" "35.5" "21.6" "26.7" "" "" "" "" "" "" "" "" "" "" "15.9" "12.5" "16.3" "18.1" "12.6" "15.4" "13.2" "16.0" "11.7" "26.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6462604528965410945" "False" "High" "IsMasterProtein" "O15392" "Baculoviral IAP repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=BIRC5 PE=1 SV=3" "0.009" "False" "2.235" "5" "1" "1" "1" "142" "16.4" "5.90" "2.56" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00653" "332" "ENSG00000089685" "BIRC5" "A2SUH6; B2R4R1; hsa:332; O15392; Q2I3N8; Q4VGX0; Q53F61; Q5MGC6; Q6FHL2; Q75SP2; Q9P2W8" "Apoptosis modulation and signaling; Interleukin-11 signaling pathway; Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Photodynamic therapy-induced NF-kB survival signaling; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; IL-4 signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Extracellular vesicles in the crosstalk of cardiac cells; Gastrin signaling pathway; Hepatitis B infection; HDAC6 interactions in the central nervous system" "Separation of Sister Chromatids; Neddylation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; SUMOylation of DNA replication proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Interleukin-4 and Interleukin-13 signaling; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "25" "0" "0.839" "1.027" "0.871" "1.235" "1.036" "1.029" "0.929" "0.909" "0.517" "83.6" "70.1" "85.9" "72.8" "103.2" "86.6" "86.0" "77.7" "76.0" "43.2" "" "" "" "" "" "" "" "" "" "" "50.0" "36.4" "47.6" "34.2" "47.9" "44.4" "40.0" "34.9" "41.2" "43.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4660808662127601060" "False" "High" "IsMasterProtein" "Q9NR09" "Baculoviral IAP repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=BIRC6 PE=1 SV=3" "0.009" "False" "2.234" "0" "1" "1" "1" "4857" "529.9" "6.05" "0.00" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00179, Pf00653, Pf12356" "57448" "ENSG00000115760" "BIRC6" "hsa:57448; Q9NR09; Q9ULD1" "" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1023835603968378243" "False" "High" "IsMasterProtein" "O75506" "Heat shock factor-binding protein 1 OS=Homo sapiens OX=9606 GN=HSBP1 PE=1 SV=1" "0.009" "False" "2.231" "14" "1" "1" "1" "76" "8.5" "4.36" "2.09" "1" "stress response;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06825" "3281" "ENSG00000230989" "HSBP1" "hsa:3281; O75506; Q53XA8; Q7Z5Z3" "" "HSF1 activation; Attenuation phase" "3" "0" "1.085" "1.123" "1.102" "1.169" "1.136" "1.165" "1.120" "1.275" "0.889" "92.3" "100.2" "103.7" "101.8" "107.9" "104.9" "107.6" "103.4" "117.7" "82.1" "" "" "" "" "" "" "" "" "" "" "55.3" "52.1" "57.4" "47.8" "50.0" "53.7" "50.0" "46.4" "63.9" "82.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8417235359346522376" "False" "High" "IsMasterProtein" "Q9NR12" "PDZ and LIM domain protein 7 OS=Homo sapiens OX=9606 GN=PDLIM7 PE=1 SV=1" "0.009" "False" "2.231" "2" "1" "1" "1" "457" "49.8" "8.41" "2.24" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595" "9260" "ENSG00000196923" "PDLIM7" "hsa:9260; Q14250; Q5XG82; Q6NVZ5; Q96C91; Q9BXB8; Q9BXB9; Q9NR12" "Ebstein-Barr virus LMP1 signaling; GDNF signaling; 5q35 copy number variation" "RET signaling" "4" "0" "0.733" "0.997" "0.933" "0.625" "0.802" "1.022" "0.655" "1.088" "1.568" "48.8" "35.8" "48.6" "45.5" "30.5" "39.1" "49.8" "31.9" "53.1" "76.5" "" "" "" "" "" "" "" "" "" "" "29.2" "18.6" "26.9" "21.4" "14.1" "20.0" "23.2" "14.3" "28.8" "76.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7106533515535511067" "False" "High" "IsMasterProtein" "Q969E8" "Pre-rRNA-processing protein TSR2 homolog OS=Homo sapiens OX=9606 GN=TSR2 PE=1 SV=1" "0.009" "False" "2.227" "4" "1" "4" "1" "191" "20.9" "4.39" "11.15" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf10273" "90121" "ENSG00000158526" "TSR2" "hsa:90121; Q969E8" "" "" "0" "0" "1.130" "1.059" "1.047" "1.200" "1.065" "1.097" "1.131" "1.118" "1.055" "358.8" "405.6" "379.9" "375.7" "430.5" "382.0" "393.6" "405.6" "401.1" "378.4" "" "" "" "" "" "" "" "" "" "" "214.7" "210.7" "210.4" "176.4" "199.5" "195.5" "183.0" "182.1" "217.6" "378.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2715683272122769400" "False" "High" "IsMasterProtein" "Q14197" "Large ribosomal subunit protein mL62 OS=Homo sapiens OX=9606 GN=MRPL58 PE=1 SV=1" "0.009" "False" "2.227" "6" "1" "1" "1" "206" "23.6" "10.07" "1.77" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "plasma membrane;other membranes;mitochondrion;translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "Pf00472" "3396" "ENSG00000167862" "MRPL58" "B2RAD1; hsa:3396; Q14197; Q53HM7; Q53Y11" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.870" "0.869" "0.858" "0.877" "1.189" "0.928" "0.824" "1.024" "2.001" "27.4" "23.9" "23.8" "23.6" "24.1" "32.6" "25.5" "22.6" "28.1" "54.9" "" "" "" "" "" "" "" "" "" "" "16.4" "12.4" "13.2" "11.1" "11.2" "16.7" "11.8" "10.2" "15.3" "54.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1991199370327280785" "False" "High" "IsMasterProtein" "Q9HD26" "Golgi-associated PDZ and coiled-coil motif-containing protein OS=Homo sapiens OX=9606 GN=GOPC PE=1 SV=1" "0.009" "False" "2.219" "2" "1" "1" "1" "462" "50.5" "5.92" "0.00" "1" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00595" "57120" "ENSG00000047932" "GOPC" "A6NM30; hsa:57120; Q59FS4; Q969U8; Q9HD26" "" "RHOQ GTPase cycle; RHO GTPases regulate CFTR trafficking" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3341461915485741514" "False" "High" "IsMasterProtein" "Q9HC36" "rRNA methyltransferase 3, mitochondrial OS=Homo sapiens OX=9606 GN=MRM3 PE=1 SV=2" "0.009" "False" "2.219" "2" "1" "1" "1" "420" "47.0" "8.73" "1.94" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00588" "55178" "ENSG00000171861" "MRM3" "hsa:55178; Q53GN1; Q86VC3; Q96F76; Q9HC36; Q9NVQ5" "" "rRNA modification in the mitochondrion" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1508097308804950005" "False" "High" "IsMasterProtein" "Q9NRP2" "COX assembly mitochondrial protein 2 homolog OS=Homo sapiens OX=9606 GN=CMC2 PE=1 SV=1" "0.009" "False" "2.217" "13" "1" "1" "1" "79" "9.5" "7.87" "1.76" "1" "" "mitochondrion" "" "Pf08583" "56942" "ENSG00000103121; ENSG00000291948" "CMC2" "D3DUK6; hsa:56942; Q9NRP2" "" "Mitochondrial protein import" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6865133109964514058" "False" "High" "IsMasterProtein" "Q9NVS2" "Large ribosomal subunit protein mL66 OS=Homo sapiens OX=9606 GN=MRPS18A PE=1 SV=1" "0.009" "False" "2.216" "5" "1" "1" "1" "196" "22.2" "10.33" "2.20" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf01084" "55168" "ENSG00000096080" "MRPS18A" "A6XND3; hsa:55168; Q5QPA4; Q9NVS2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3468928122779261644" "False" "High" "IsMasterProtein" "P51398" "Small ribosomal subunit protein mS29 OS=Homo sapiens OX=9606 GN=DAP3 PE=1 SV=1" "0.009" "False" "2.208" "4" "1" "1" "1" "398" "45.5" "8.88" "1.63" "1" "protein metabolism;other metabolic processes;signal transduction" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf10236" "7818" "ENSG00000132676" "DAP3" "B4DP59; B4DY62; E7EM60; hsa:7818; P51398; Q13044; Q68CT7; Q96Q20" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6795582567929622559" "False" "High" "IsMasterProtein" "P61916" "NPC intracellular cholesterol transporter 2 OS=Homo sapiens OX=9606 GN=NPC2 PE=1 SV=1" "0.009" "False" "2.200" "5" "1" "2" "1" "151" "16.6" "7.65" "5.22" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf02221" "10577" "ENSG00000119655" "NPC2" "B4DQV7; P61916; Q15668; Q29413" "TYROBP causal network in microglia; Degradation pathway of sphingolipids, including diseases; Ebola virus infection in host; Cholesterol metabolism; Fatty acids and lipoproteins transport in hepatocytes" "Neutrophil degranulation; LDL clearance" "7" "0" "1.069" "1.009" "1.043" "0.810" "1.072" "1.092" "1.099" "1.065" "0.674" "188.9" "202.0" "190.6" "197.1" "153.0" "202.5" "206.3" "207.7" "201.2" "127.3" "" "" "" "" "" "" "" "" "" "" "113.1" "105.0" "105.5" "92.5" "70.9" "103.7" "95.9" "93.2" "109.2" "127.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3574208382527803870" "False" "High" "IsMasterProtein" "Q9Y2X7" "ARF GTPase-activating protein GIT1 OS=Homo sapiens OX=9606 GN=GIT1 PE=1 SV=2" "0.010" "False" "2.196" "1" "1" "1" "1" "761" "84.3" "6.80" "0.00" "1" "transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf01412, Pf08518, Pf12205, Pf12796, Pf16559" "28964" "ENSG00000108262" "GIT1" "B4DGU9; B4DSV3; hsa:28964; Q86SS0; Q9BRJ4; Q9Y2X7" "CAMKK2 pathway; Regulation of actin cytoskeleton" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Ephrin signaling; Activation of RAC1 downstream of NMDARs" "12" "0" "0.941" "0.873" "0.860" "0.959" "0.928" "0.989" "0.445" "0.850" "2.565" "41.5" "39.1" "36.3" "35.8" "39.8" "38.6" "41.1" "18.5" "35.3" "106.6" "" "" "" "" "" "" "" "" "" "" "24.9" "20.3" "20.1" "16.8" "18.5" "19.7" "19.1" "8.3" "19.2" "106.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7829507115951982075" "False" "High" "IsMasterProtein" "P19387" "DNA-directed RNA polymerase II subunit RPB3 OS=Homo sapiens OX=9606 GN=POLR2C PE=1 SV=2" "0.010" "False" "2.190" "6" "1" "1" "1" "275" "31.4" "4.92" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01000, Pf01193" "5432" "ENSG00000102978" "POLR2C" "hsa:5432; O15161; P19387" "Pyrimidine metabolism; Eukaryotic transcription initiation; Primary ovarian insufficiency" "mRNA Splicing - Major Pathway; Transcriptional regulation by small RNAs; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Inhibition of DNA recombination at telomere; Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "44" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6599360429670756188" "False" "High" "IsMasterProtein" "Q92902" "BLOC-3 complex member HPS1 OS=Homo sapiens OX=9606 GN=HPS1 PE=1 SV=2" "0.010" "False" "2.182" "1" "1" "3" "1" "700" "79.2" "5.91" "8.15" "1" "cell organization and biogenesis;transport;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf19036, Pf19037, Pf19038" "3257" "ENSG00000107521" "HPS1" "A8MRT2; O15402; O15502; Q5TAA3; Q8WXE5; Q92902" "IL-18 signaling pathway" "RAB GEFs exchange GTP for GDP on RABs" "2" "0" "0.916" "0.794" "0.878" "0.837" "0.860" "0.845" "0.788" "0.889" "0.700" "326.3" "298.8" "259.0" "286.3" "273.1" "280.7" "275.8" "257.2" "290.1" "228.3" "" "" "" "" "" "" "" "" "" "" "195.3" "155.3" "143.4" "134.4" "126.6" "143.7" "128.3" "115.5" "157.4" "228.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1750728532915828857" "False" "High" "IsMasterProtein" "P26010" "Integrin beta-7 OS=Homo sapiens OX=9606 GN=ITGB7 PE=1 SV=1" "0.010" "False" "2.179" "1" "1" "1" "1" "798" "86.8" "6.04" "2.25" "1" "cell adhesion;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00362, Pf07974, Pf08725, Pf17205" "3695" "ENSG00000139626" "ITGB7" "hsa:3695; P26010; Q9UCP7; Q9UCS7" "Integrin-mediated cell adhesion; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5130532040742567239" "False" "High" "IsMasterProtein" "Q9HCN8" "Stromal cell-derived factor 2-like protein 1 OS=Homo sapiens OX=9606 GN=SDF2L1 PE=1 SV=2" "0.010" "False" "2.177" "4" "1" "3" "1" "221" "23.6" "7.03" "8.57" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf02815" "23753" "ENSG00000128228" "SDF2L1" "A2RUD3; hsa:23753; Q9BRI5; Q9HCN8" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.941" "0.980" "1.022" "0.979" "1.105" "1.088" "1.160" "1.040" "0.902" "473.9" "445.8" "464.3" "484.4" "464.0" "523.8" "515.9" "549.9" "492.8" "427.7" "" "" "" "" "" "" "" "" "" "" "283.6" "231.7" "257.1" "227.4" "215.1" "268.1" "239.9" "246.9" "267.4" "427.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4314325281228425264" "False" "Medium" "IsMasterProtein" "O15382" "Branched-chain-amino-acid aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=BCAT2 PE=1 SV=2" "0.010" "False" "2.172" "2" "1" "1" "1" "392" "44.3" "8.65" "2.01" "1" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf01063" "587" "ENSG00000105552" "BCAT2" "B2RB87; hsa:587; O00269; O15382; Q96KG1; Q9BTB6; Q9BUU6" "Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways" "Branched-chain amino acid catabolism" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6821127370945399140" "False" "Medium" "IsMasterProtein" "Q5JVF3" "PCI domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PCID2 PE=1 SV=2" "0.010" "False" "2.172" "2" "1" "1" "1" "399" "46.0" "8.53" "2.30" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01399" "55795" "ENSG00000126226" "PCID2" "A6NK09; hsa:55795; Q3ZCX1; Q5JVF3; Q5TC57; Q5TC58; Q9H7K1; Q9HBZ7; Q9NUK6; Q9NVY1; Q9NW44; Q9NWH3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3275196182656961977" "False" "Medium" "IsMasterProtein" "Q8WXB1" "Protein N-lysine methyltransferase METTL21A OS=Homo sapiens OX=9606 GN=METTL21A PE=1 SV=2" "0.010" "False" "2.169" "3" "1" "1" "1" "218" "24.6" "6.27" "2.16" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf10294" "151194" "ENSG00000144401" "METTL21A" "hsa:151194; Q53RV0; Q8N1Z9; Q8WXB1; Q96GH6" "" "Protein methylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1940772277811891477" "False" "Medium" "IsMasterProtein" "Q96PM5" "RING finger and CHY zinc finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCHY1 PE=1 SV=1" "0.010" "False" "2.168" "4" "1" "1" "1" "261" "30.1" "6.71" "0.00" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05495, Pf13639, Pf14599" "25898" "ENSG00000163743" "RCHY1" "B3KRG3; C7E541; C7E542; C7E543; D3YRV2; E7EMC8; E7ETW5; J3KPI0; Q2KN33; Q59GN7; Q86X26; Q96PM5; Q96PR5" "Measles virus infection" "Antigen processing: Ubiquitination & Proteasome degradation; Translesion Synthesis by POLH" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1585817169106109779" "False" "Medium" "IsMasterProtein" "Q9P2D1" "Chromodomain-helicase-DNA-binding protein 7 OS=Homo sapiens OX=9606 GN=CHD7 PE=1 SV=3" "0.010" "False" "2.167" "0" "1" "1" "1" "2997" "335.7" "6.34" "0.00" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf07533" "55636" "ENSG00000171316" "CHD7" "D0VBA5; E9PNZ2; hsa:55636; Q05DI5; Q2TAN4; Q66K35; Q7Z6C0; Q7Z7Q2; Q9NXA0; Q9NXA3; Q9P2D1" "Kallmann syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "Not Found" "High" "High" "High" "1" "" "-7897691878290275966" "False" "Medium" "IsMasterProtein" "Q9Y680" "Peptidyl-prolyl cis-trans isomerase FKBP7 OS=Homo sapiens OX=9606 GN=FKBP7 PE=1 SV=2" "0.010" "False" "2.166" "5" "1" "1" "1" "222" "25.8" "6.32" "0.00" "1" "protein metabolism;other metabolic processes" "ER/Golgi" "other molecular function" "Pf00254, Pf13202" "51661" "ENSG00000079150" "FKBP7" "hsa:51661; Q4ZG70; Q6V3B2; Q86U65; Q96DA4; Q9Y680; Q9Y6B0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2858962051142088186" "False" "Medium" "IsMasterProtein" "Q8WXE1" "ATR-interacting protein OS=Homo sapiens OX=9606 GN=ATRIP PE=1 SV=1" "0.010" "False" "2.163" "1" "1" "2" "1" "791" "85.8" "6.32" "4.05" "1" "DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "other molecular function" "" "84126" "ENSG00000164053" "ATRIP" "A8K6A3; A8K714; B2RCE7; B4DU92; B5MEB7; hsa:84126; Q69YK9; Q8NHQ2; Q8WUG7; Q8WXE1; Q96CL3; Q9HA30" "miRNA regulation of DNA damage response; ATR signaling; DNA damage response" "Fanconi Anemia Pathway; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "11" "0" "0.952" "0.950" "1.113" "1.073" "0.894" "1.175" "0.911" "0.973" "0.606" "150.0" "142.7" "142.5" "166.9" "161.0" "134.1" "176.2" "136.7" "145.9" "91.0" "" "" "" "" "" "" "" "" "" "" "89.8" "74.2" "78.9" "78.4" "74.6" "68.6" "81.9" "61.4" "79.1" "91.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3408450596310404748" "False" "Medium" "IsMasterProtein" "Q9UHA4" "Ragulator complex protein LAMTOR3 OS=Homo sapiens OX=9606 GN=LAMTOR3 PE=1 SV=1" "0.010" "False" "2.163" "6" "1" "1" "1" "124" "13.6" "7.34" "2.72" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf08923" "8649" "ENSG00000109270" "LAMTOR3" "B2R4A1; hsa:8649; J3KMX4; Q9H364; Q9UHA4" "MAPK signaling pathway; MAPK cascade; Gastrin signaling pathway; Melanoma" "Neutrophil degranulation; Amino acids regulate mTORC1; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; MAP2K and MAPK activation; Regulation of PTEN gene transcription; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "13" "0" "0.847" "0.902" "0.857" "0.915" "0.940" "1.017" "0.878" "1.052" "0.821" "190.9" "161.7" "172.2" "163.5" "174.8" "179.4" "194.1" "167.6" "200.8" "156.8" "" "" "" "" "" "" "" "" "" "" "114.2" "84.0" "95.3" "76.8" "81.0" "91.8" "90.3" "75.2" "108.9" "156.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3867715510256549408" "False" "Medium" "IsMasterProtein" "P49757" "Protein numb homolog OS=Homo sapiens OX=9606 GN=NUMB PE=1 SV=2" "0.010" "False" "2.158" "2" "1" "1" "1" "651" "70.8" "8.51" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00640, Pf06311" "8650" "ENSG00000133961" "NUMB" "B1P2N5; B1P2N6; B1P2N7; B1P2N8; B1P2N9; B4E2B1; hsa:8650; P49757; Q6NUQ7; Q86SY1; Q8WW73; Q9UBG1; Q9UEQ4; Q9UKE8; Q9UKE9; Q9UKF0; Q9UQJ4" "Notch signaling; VEGFA-VEGFR2 signaling; Head and neck squamous cell carcinoma; Neurogenesis regulation in the olfactory epithelium; TROP2 regulatory signaling; Notch signaling pathway" "Recycling pathway of L1; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus" "10" "0" "1.252" "1.624" "0.997" "1.484" "0.759" "1.489" "1.493" "1.317" "1.739" "20.6" "25.8" "33.5" "20.5" "30.6" "15.6" "30.7" "30.7" "27.1" "35.8" "" "" "" "" "" "" "" "" "" "" "12.3" "13.4" "18.5" "9.6" "14.2" "8.0" "14.3" "13.8" "14.7" "35.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3564822305630524625" "False" "Medium" "IsMasterProtein" "Q96M27" "Protein PRRC1 OS=Homo sapiens OX=9606 GN=PRRC1 PE=1 SV=1" "0.010" "False" "2.154" "2" "1" "1" "1" "445" "46.7" "5.83" "2.51" "1" "" "ER/Golgi;other cell component" "other molecular function" "Pf01931" "133619" "ENSG00000164244" "PRRC1" "hsa:133619; Q69YM8; Q7L2U7; Q86Y42; Q8IVJ4; Q8IVL4; Q8NEZ7; Q96AJ3; Q96M27" "" "" "0" "0" "0.959" "0.921" "0.970" "0.977" "1.106" "0.863" "0.940" "0.981" "0.880" "199.8" "191.6" "183.9" "193.7" "195.2" "220.9" "172.3" "187.9" "195.9" "175.8" "" "" "" "" "" "" "" "" "" "" "119.5" "99.5" "101.8" "90.9" "90.5" "113.1" "80.1" "84.3" "106.3" "175.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2957906910240928632" "False" "Medium" "IsMasterProtein" "P22033" "Methylmalonyl-CoA mutase, mitochondrial OS=Homo sapiens OX=9606 GN=MMUT PE=1 SV=4" "0.010" "False" "2.151" "1" "1" "1" "1" "750" "83.1" "6.93" "2.04" "1" "other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf01642, Pf02310" "4594" "ENSG00000146085" "MMUT" "A8K953; hsa:4594; P22033; Q5SYZ3; Q96B11; Q9UD64" "Vitamin B12 metabolism; Amino acid metabolism" "Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM; Cobalamin (Cbl) metabolism" "6" "0" "1.133" "1.128" "1.138" "2.197" "1.372" "0.923" "1.200" "1.103" "2.682" "12.4" "14.1" "14.0" "14.1" "27.3" "17.1" "11.5" "14.9" "13.7" "33.3" "" "" "" "" "" "" "" "" "" "" "7.4" "7.3" "7.8" "6.6" "12.7" "8.7" "5.3" "6.7" "7.4" "33.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-180619704287479053" "False" "Medium" "IsMasterProtein" "P01137" "Transforming growth factor beta-1 proprotein OS=Homo sapiens OX=9606 GN=TGFB1 PE=1 SV=3" "0.010" "False" "2.147" "2" "1" "1" "1" "390" "44.3" "8.53" "2.57" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00019, Pf00688" "7040" "ENSG00000105329" "TGFB1" "A8K792; hsa:7040; P01137; Q9UCG4" "MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Cell cycle; Allograft rejection; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Cardiac progenitor differentiation; Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Cardiac hypertrophic response; Mammary gland development pathway - Embryonic development (Stage 1 of 4); Pluripotent stem cell differentiation pathway; Endoderm differentiation; Dopaminergic neurogenesis; IL-3 signaling pathway; Extracellular vesicle-mediated signaling in recipient cells; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Lung fibrosis; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Interactions between LOXL4 and oxidative stress pathway; MAPK signaling pathway; Canonical and non-canonical TGF-B signaling; Clear cell renal cell carcinoma pathways; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Type 2 papillary renal cell carcinoma; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Neovascularization processes; Nonalcoholic fatty liver disease; Platelet-mediated interactions with vascular and circulating cells; Control of immune tolerance by vasoactive intestinal peptide; Selective expression of chemokine receptors during T-cell polarization; Signal transduction through IL1R; Envelope proteins and their potential roles in EDMD physiopathology; Interactions between immune cells and microRNAs in tumor microenvironment; Hepatitis B infection; Endochondral ossification; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Overlap between signal transduction pathways contributing to LMNA laminopathies; 3q29 copy number variation syndrome; Angiotensin II receptor type 1 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; T cell modulation in pancreatic cancer; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Complement system in neuronal development and plasticity; Overview of proinflammatory and profibrotic mediators; CCL18 signaling pathway; Progeria-associated lipodystrophy; Th17 cell differentiation pathway; Urotensin-II-mediated signaling pathway; Ulcerative colitis signaling; Inflammatory bowel disease signaling; Clock-controlled autophagy in bone metabolism; Markers of kidney cell lineage; Comprehensive IL-17A signaling; Cell interactions of the pancreatic cancer microenvironment; Immune infiltration in pancreatic cancer; Cytokines and inflammatory response; 1p36 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; Affected pathways in Duchenne muscular dystrophy; IL-19 signaling pathway; ACE inhibitor pathway; TGF-beta receptor signaling; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "Transcriptional regulation of white adipocyte differentiation; Cell surface interactions at the vascular wall; UCH proteinases; ECM proteoglycans; Platelet degranulation ; Regulation of RUNX3 expression and activity; Interleukin-4 and Interleukin-13 signaling; Syndecan interactions; Downregulation of TGF-beta receptor signaling; Molecules associated with elastic fibres; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; RUNX3 regulates p14-ARF; Influenza Virus Induced Apoptosis; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); TGFBR2 MSI Frameshift Mutants in Cancer; TGFBR2 Kinase Domain Mutants in Cancer; TGFBR1 LBD Mutants in Cancer; RUNX3 regulates CDKN1A transcription" "95" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "660513057168003161" "False" "Medium" "IsMasterProtein" "Q99805" "Transmembrane 9 superfamily member 2 OS=Homo sapiens OX=9606 GN=TM9SF2 PE=1 SV=1" "0.010" "False" "2.147" "1" "1" "1" "1" "663" "75.7" "7.44" "0.00" "1" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle" "" "Pf02990" "9375" "ENSG00000125304" "TM9SF2" "A8K399; hsa:9375; Q2TAY5; Q99805" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "582663252060756755" "False" "Medium" "IsMasterProtein" "Q9NVX7" "Kelch repeat and BTB domain-containing protein 4 OS=Homo sapiens OX=9606 GN=KBTBD4 PE=1 SV=4" "0.010" "False" "2.137" "1" "1" "1" "1" "534" "59.9" "5.77" "2.16" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3551068469878704149" "False" "Medium" "IsMasterProtein" "Q9H0U6" "Large ribosomal subunit protein uL18m OS=Homo sapiens OX=9606 GN=MRPL18 PE=1 SV=1" "0.010" "False" "2.134" "4" "1" "1" "1" "180" "20.6" "9.54" "2.00" "1" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00861" "29074" "ENSG00000112110" "MRPL18" "hsa:29074; Q5TAP9; Q9H0U6; Q9NZW8" "" "Mitochondrial translation elongation; Mitochondrial translation initiation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7021380242978739287" "False" "Medium" "IsMasterProtein" "Q92797" "Symplekin OS=Homo sapiens OX=9606 GN=SYMPK PE=1 SV=2" "0.010" "False" "2.133" "1" "1" "1" "1" "1274" "141.1" "6.13" "1.91" "1" "cell adhesion;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf11935, Pf12295" "8189" "ENSG00000125755" "SYMPK" "hsa:8189; O00521; O00689; O00733; Q59GT5; Q8N2U5; Q92797" "" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.585" "1.216" "1.392" "1.366" "1.763" "1.426" "0.800" "1.518" "3.447" "16.5" "26.2" "20.1" "23.0" "22.5" "29.1" "23.5" "13.2" "25.1" "56.9" "" "" "" "" "" "" "" "" "" "" "9.9" "13.6" "11.1" "10.8" "10.5" "14.9" "10.9" "5.9" "13.6" "56.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "680199301258843894" "False" "Medium" "IsMasterProtein" "O95229" "ZW10 interactor OS=Homo sapiens OX=9606 GN=ZWINT PE=1 SV=2" "0.010" "False" "2.133" "4" "1" "1" "1" "277" "31.3" "5.15" "1.69" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf15556" "11130" "ENSG00000122952" "ZWINT" "A6NNV6; hsa:11130; O95229; Q0D2I3; Q9BWD0" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.240" "2.214" "2.008" "1.059" "1.272" "2.144" "1.788" "1.569" "2.832" "13.8" "17.1" "30.5" "27.6" "14.6" "17.5" "29.5" "24.6" "21.6" "39.0" "" "" "" "" "" "" "" "" "" "" "8.2" "8.9" "16.9" "13.0" "6.8" "9.0" "13.7" "11.0" "11.7" "39.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6857356928160301149" "False" "Medium" "IsMasterProtein" "Q9C0E8" "Endoplasmic reticulum junction formation protein lunapark OS=Homo sapiens OX=9606 GN=LNPK PE=1 SV=2" "0.010" "False" "2.131" "2" "1" "1" "1" "428" "47.7" "5.11" "1.74" "1" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf10058" "80856" "ENSG00000144320" "LNPK" "B7ZLA8; hsa:80856; Q2M2V8; Q2YD99; Q658W8; Q8N5V9; Q96MS5; Q9C0E8" "" "" "0" "0" "0.781" "0.838" "1.114" "1.059" "0.725" "1.188" "1.481" "1.125" "0.386" "27.3" "21.3" "22.9" "30.4" "28.9" "19.8" "32.4" "40.4" "30.7" "10.5" "" "" "" "" "" "" "" "" "" "" "16.3" "11.1" "12.7" "14.3" "13.4" "10.1" "15.1" "18.2" "16.7" "10.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8700335326144916466" "False" "Medium" "IsMasterProtein" "Q9UET6" "tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase OS=Homo sapiens OX=9606 GN=FTSJ1 PE=1 SV=2" "0.011" "False" "2.128" "3" "1" "1" "1" "329" "36.1" "5.69" "0.00" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01728" "24140" "ENSG00000068438" "FTSJ1" "B2RCJ0; hsa:24140; O75670; Q9UET6" "" "tRNA modification in the nucleus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5151232376153751801" "False" "Medium" "IsMasterProtein" "Q9UIM3" "FK506-binding protein-like OS=Homo sapiens OX=9606 GN=FKBPL PE=1 SV=1" "0.011" "False" "2.128" "2" "1" "1" "1" "349" "38.2" "5.50" "1.79" "1" "other biological processes" "non-structural extracellular;cytosol" "" "Pf00515" "63943" "ENSG00000204315; ENSG00000223666; ENSG00000224200; ENSG00000230907" "FKBPL" "A8K5V3; B0UYX8; hsa:63943; Q9H5G3; Q9UIM3" "" "The role of GTSE1 in G2/M progression after G2 checkpoint" "1" "0" "0.964" "0.903" "1.209" "0.856" "0.780" "0.923" "1.017" "0.923" "0.864" "44.7" "43.1" "40.4" "54.1" "38.3" "34.9" "41.3" "45.4" "41.3" "38.6" "" "" "" "" "" "" "" "" "" "" "26.8" "22.4" "22.3" "25.4" "17.7" "17.9" "19.2" "20.4" "22.4" "38.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2814878339460431936" "False" "Medium" "IsMasterProtein" "O43819" "Protein SCO2 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=SCO2 PE=1 SV=3" "0.011" "False" "2.128" "4" "1" "1" "1" "266" "29.8" "8.85" "0.00" "1" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "other membranes;cytoskeleton;mitochondrion" "other molecular function" "Pf02630" "9997" "ENSG00000284194" "SCO2" "hsa:9997; O43819; Q3T1B5; Q9UK87" "p53 transcriptional gene network" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4874670657009698466" "False" "Medium" "IsMasterProtein" "Q6P2Q9" "Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens OX=9606 GN=PRPF8 PE=1 SV=2" "0.011" "False" "2.125" "0" "1" "1" "1" "2335" "273.4" "8.84" "2.17" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01398, Pf08082, Pf08083, Pf08084, Pf10596, Pf10597, Pf10598, Pf12134" "10594" "ENSG00000174231; ENSG00000274442" "PRPF8" "hsa:10594; O14547; O75965; Q6P2Q9" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3567391987631389580" "False" "Medium" "IsMasterProtein" "Q9BZA7" "Protocadherin-11 X-linked OS=Homo sapiens OX=9606 GN=PCDH11X PE=1 SV=1" "0.011" "False" "2.121" "1" "1" "1" "1" "1347" "147.5" "5.21" "2.23" "1" "cell adhesion" "plasma membrane;other membranes" "other molecular function" "Pf00028, Pf08266, Pf08374" "27328" "ENSG00000102290" "PCDH11X" "A6NIQ4; hsa:27328; Q2TJH0; Q2TJH1; Q2TJH3; Q5JVZ0; Q70LR8; Q70LS7; Q70LS8; Q70LS9; Q70LT7; Q70LT8; Q70LT9; Q70LU0; Q70LU1; Q96RV4; Q96RW0; Q9BZA6; Q9BZA7; Q9H4E0; Q9P2M0; Q9P2X5" "" "" "0" "0" "1.049" "0.958" "0.949" "1.159" "0.894" "0.791" "1.120" "0.629" "0.611" "98.9" "103.8" "94.7" "93.8" "114.7" "88.4" "78.2" "110.8" "62.2" "60.4" "" "" "" "" "" "" "" "" "" "" "59.2" "53.9" "52.5" "44.0" "53.1" "45.2" "36.4" "49.7" "33.7" "60.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518810540954697302" "False" "Medium" "IsMasterProtein" "Q8TAT6" "Nuclear protein localization protein 4 homolog OS=Homo sapiens OX=9606 GN=NPLOC4 PE=1 SV=3" "0.011" "False" "2.115" "1" "1" "1" "1" "608" "68.1" "6.38" "2.98" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf05020, Pf05021, Pf11543" "55666" "ENSG00000182446" "NPLOC4" "hsa:55666; Q8N3J1; Q8TAT6; Q9H8V2; Q9H964; Q9NWR5; Q9P229" "" "Neddylation; KEAP1-NFE2L2 pathway; Translesion Synthesis by POLH" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7175242905837588229" "False" "Medium" "IsMasterProtein" "O95747" "Serine/threonine-protein kinase OSR1 OS=Homo sapiens OX=9606 GN=OXSR1 PE=1 SV=1" "0.011" "False" "2.110" "2" "1" "1" "1" "527" "58.0" "6.43" "2.09" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12202" "9943" "ENSG00000172939" "OXSR1" "hsa:9943; O95747; Q3LR53; Q7Z501; Q9UPQ1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5146194763557846941" "False" "Medium" "IsMasterProtein" "Q9Y613" "FH1/FH2 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FHOD1 PE=1 SV=3" "0.011" "False" "2.102" "2" "1" "1" "1" "1164" "126.5" "6.39" "0.00" "1" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02181, Pf18382" "29109" "ENSG00000135723" "FHOD1" "hsa:29109; Q59F76; Q6Y1F2; Q76MS8; Q8N521; Q9Y613" "VEGFA-VEGFR2 signaling" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "Not Found" "High" "High" "High" "1" "" "4173136633731686100" "False" "Medium" "IsMasterProtein" "P29590" "Protein PML OS=Homo sapiens OX=9606 GN=PML PE=1 SV=3" "0.011" "False" "2.098" "1" "1" "1" "1" "882" "97.5" "6.21" "2.18" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097, Pf00643, Pf12126" "5371" "ENSG00000140464" "PML" "E9PBR7; hsa:5371; P29590; P29591; P29592; P29593; Q00755; Q15959; Q59FP9; Q8WUA0; Q96S41; Q9BPW2; Q9BWP7; Q9BZX6; Q9BZX7; Q9BZX8; Q9BZX9; Q9BZY0; Q9BZY2; Q9BZY3" "miRNA regulation of DNA damage response; Wnt/beta-catenin signaling pathway in leukemia; TGF-beta signaling pathway; p53 transcriptional gene network; Acute myeloid leukemia; DNA damage response" "Interferon gamma signaling; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Regulation of TP53 Activity through Acetylation; Regulation of PTEN localization; Regulation of RUNX1 Expression and Activity" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4145241579063427930" "False" "Medium" "IsMasterProtein" "P68400" "Casein kinase II subunit alpha OS=Homo sapiens OX=9606 GN=CSNK2A1 PE=1 SV=1" "0.011" "False" "2.094" "2" "1" "1" "1" "391" "45.1" "7.74" "2.25" "1" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1457" "ENSG00000101266" "CSNK2A1" "B4DYS6; D3DVV8; hsa:1457; P19138; P20426; P68400; Q14013; Q5U065" "Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Pleural mesothelioma; Alzheimer's disease" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC" "22" "0" "0.827" "0.735" "1.004" "0.693" "0.763" "0.742" "0.823" "0.937" "1.998" "82.8" "68.5" "60.9" "83.1" "57.4" "63.2" "61.5" "68.2" "77.6" "165.6" "" "" "" "" "" "" "" "" "" "" "49.6" "35.6" "33.7" "39.0" "26.6" "32.4" "28.6" "30.6" "42.1" "165.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9053740260663860944" "False" "Medium" "IsMasterProtein" "Q9NZN8" "CCR4-NOT transcription complex subunit 2 OS=Homo sapiens OX=9606 GN=CNOT2 PE=1 SV=1" "0.011" "False" "2.094" "2" "1" "1" "1" "540" "59.7" "7.66" "2.44" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04153" "4848" "ENSG00000111596" "CNOT2" "hsa:4848; Q9H3E0; Q9NSX5; Q9NWR6; Q9NZN8; Q9P028" "" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5219962160653880547" "False" "Medium" "IsMasterProtein" "Q15785" "Mitochondrial import receptor subunit TOM34 OS=Homo sapiens OX=9606 GN=TOMM34 PE=1 SV=2" "0.011" "False" "2.092" "3" "1" "1" "1" "309" "34.5" "8.98" "2.46" "1" "other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00515" "10953" "ENSG00000025772" "TOMM34" "hsa:10953; Q15785; Q53GH9; Q6IBN7; Q9NTZ3" "" "" "0" "0" "1.113" "1.247" "0.854" "1.105" "0.854" "1.167" "0.189" "1.313" "9.776" "30.5" "34.0" "38.1" "26.1" "33.7" "26.1" "35.6" "5.8" "40.1" "298.6" "" "" "" "" "" "" "" "" "" "" "18.3" "17.7" "21.1" "12.2" "15.6" "13.3" "16.6" "2.6" "21.8" "298.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5322570357493023656" "False" "Medium" "IsMasterProtein" "Q8IUQ0" "Clavesin-1 OS=Homo sapiens OX=9606 GN=CLVS1 PE=1 SV=1" "0.011" "False" "2.088" "4" "1" "1" "1" "354" "40.8" "7.20" "0.00" "1" "cell organization and biogenesis" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00650, Pf03765" "157807" "ENSG00000177182" "CLVS1" "B2R7M5; C8UZT3; Q8IUQ0; Q8NB32" "Ectoderm differentiation" "Lysosome Vesicle Biogenesis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2737319948807008641" "False" "Medium" "IsMasterProtein" "Q9H8G2" "Caspase activity and apoptosis inhibitor 1 OS=Homo sapiens OX=9606 GN=CAAP1 PE=1 SV=2" "0.011" "False" "2.087" "2" "1" "1" "1" "361" "38.3" "4.72" "2.00" "1" "other biological processes" "" "" "Pf15335" "79886" "ENSG00000120159" "CAAP1" "B4DWT4; D3DRK4; hsa:79886; Q5VY32; Q6IPE6; Q96C59; Q9H8G2" "Acute viral myocarditis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3253297407861631258" "False" "Medium" "IsMasterProtein" "O95155" "Ubiquitin conjugation factor E4 B OS=Homo sapiens OX=9606 GN=UBE4B PE=1 SV=1" "0.011" "False" "2.086" "1" "1" "1" "1" "1302" "146.1" "6.55" "2.09" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04564, Pf10408" "10277" "ENSG00000130939" "UBE4B" "A8K8S9; G0ZJH6; O75169; O95155; O95338; Q5SZ12; Q5SZ16; Q96QD4; Q9BYI7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-572232975925861742" "False" "Medium" "IsMasterProtein" "P46779" "Large ribosomal subunit protein eL28 OS=Homo sapiens OX=9606 GN=RPL28 PE=1 SV=3" "0.011" "False" "2.083" "5" "1" "1" "1" "137" "15.7" "12.02" "1.84" "1" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01778" "6158" "ENSG00000108107" "RPL28" "B2R4A6; B4DEP9; C9JB50; E9PB24; G5E9L2; hsa:6158; P46779; Q6IAY0; Q96FX1; Q9BWQ0" "Cytoplasmic ribosomal proteins" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.217" "1.067" "0.948" "1.033" "1.210" "1.178" "0.859" "1.129" "0.874" "37.6" "45.8" "40.1" "35.7" "38.9" "45.5" "44.3" "32.3" "42.5" "32.9" "" "" "" "" "" "" "" "" "" "" "22.5" "23.8" "22.2" "16.7" "18.0" "23.3" "20.6" "14.5" "23.0" "32.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2213964009562645664" "False" "Medium" "IsMasterProtein" "Q9Y221" "60S ribosome subunit biogenesis protein NIP7 homolog OS=Homo sapiens OX=9606 GN=NIP7 PE=1 SV=1" "0.011" "False" "2.082" "4" "1" "1" "1" "180" "20.4" "8.51" "2.98" "1" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "Pf03657, Pf17833" "51388" "ENSG00000132603" "NIP7" "B2RD04; hsa:51388; Q9NZZ0; Q9Y221" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5986352754293277242" "False" "Medium" "IsMasterProtein" "P61513" "Large ribosomal subunit protein eL43 OS=Homo sapiens OX=9606 GN=RPL37A PE=1 SV=2" "0.011" "False" "2.081" "9" "1" "1" "1" "92" "10.3" "10.43" "2.68" "1" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01780" "6168" "ENSG00000197756" "RPL37A" "hsa:6168; P12751; P61513; Q6FGF5" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Selenocysteine synthesis; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4946696058487786946" "False" "Medium" "IsMasterProtein" "Q9UHJ6" "Sedoheptulokinase OS=Homo sapiens OX=9606 GN=SHPK PE=1 SV=4" "0.011" "False" "2.081" "3" "1" "1" "1" "478" "51.5" "6.83" "2.14" "1" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00370" "23729" "ENSG00000197417" "SHPK" "B2R640; Q8WUH3; Q9UHJ6" "" "Pentose phosphate pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9163044576809599647" "False" "Medium" "IsMasterProtein" "P0DPB6" "DNA-directed RNA polymerases I and III subunit RPAC2 OS=Homo sapiens OX=9606 GN=POLR1D PE=1 SV=1" "0.011" "False" "2.080" "10" "1" "1" "1" "133" "15.2" "5.80" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01193, Pf13656" "51082" "ENSG00000186184" "POLR1D" "hsa:51082; P0DPB6; Q5TBX2; Q96BR3; Q9Y2S0" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "" "4" "0" "0.499" "0.508" "1.318" "0.758" "0.526" "1.212" "0.010" "0.497" "5.696" "13.5" "6.7" "6.9" "17.8" "10.2" "7.1" "16.3" "0.0" "6.7" "76.8" "" "" "" "" "" "" "" "" "" "" "8.1" "3.5" "3.8" "8.3" "4.7" "3.6" "7.6" "0.0" "3.6" "76.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "Not Found" "High" "High" "1" "" "5954226143684266914" "False" "Medium" "IsMasterProtein" "P10398" "Serine/threonine-protein kinase A-Raf OS=Homo sapiens OX=9606 GN=ARAF PE=1 SV=2" "0.011" "False" "2.080" "2" "1" "1" "1" "606" "67.5" "9.01" "2.09" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00130, Pf02196, Pf07714" "369" "ENSG00000078061" "ARAF" "hsa:369; P07557; P10398; Q5H9B2; Q5H9B3" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; Common pathways underlying drug addiction; Bladder cancer; MAPK signaling pathway; Embryonic stem cell pluripotency pathways; Endometrial cancer; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Fragile X syndrome; Hepatitis B infection; Melanoma; EGFR tyrosine kinase inhibitor resistance; Alzheimer's disease; Acute myeloid leukemia; ErbB signaling pathway" "Signaling by BRAF and RAF1 fusions; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "33" "0" "0.857" "0.991" "0.816" "0.950" "0.789" "0.854" "0.715" "0.801" "3.584" "20.9" "17.9" "20.7" "17.1" "19.8" "16.5" "17.9" "14.9" "16.8" "74.9" "" "" "" "" "" "" "" "" "" "" "12.5" "9.3" "11.5" "8.0" "9.2" "8.4" "8.3" "6.7" "9.1" "74.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5319872679741064952" "False" "Medium" "IsMasterProtein" "P22570" "NADPH:adrenodoxin oxidoreductase, mitochondrial OS=Homo sapiens OX=9606 GN=FDXR PE=1 SV=3" "0.011" "False" "2.078" "2" "1" "1" "1" "491" "53.8" "8.44" "2.52" "1" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf07992" "2232" "ENSG00000161513" "FDXR" "B4DDI7; B4DHX5; B4DQQ4; B4DX24; B7Z7G2; E7EQC1; hsa:2232; P22570; Q13716; Q4PJI0; Q9BU12" "Iron-sulfur cluster biogenesis" "Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6253369152743795153" "False" "Medium" "IsMasterProtein" "Q8TD16" "Protein bicaudal D homolog 2 OS=Homo sapiens OX=9606 GN=BICD2 PE=1 SV=1" "0.011" "False" "2.078" "1" "1" "1" "1" "824" "93.5" "5.44" "2.13" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf09730" "23299" "ENSG00000185963" "BICD2" "hsa:23299; O75181; Q5TBQ2; Q5TBQ3; Q8TD16; Q96LH2; Q9BT84; Q9H561" "" "COPI-independent Golgi-to-ER retrograde traffic" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8005883181375695291" "False" "Medium" "IsMasterProtein" "Q9P260" "RAB11-binding protein RELCH OS=Homo sapiens OX=9606 GN=RELCH PE=1 SV=2" "0.011" "False" "2.076" "1" "1" "1" "1" "1216" "134.5" "5.45" "0.00" "1" "transport" "ER/Golgi;other cytoplasmic organelle" "" "" "57614" "ENSG00000134444" "RELCH" "hsa:57614; Q9P260" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "High" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "High" "1" "" "1808249622791758823" "False" "Medium" "IsMasterProtein" "Q92794" "Histone acetyltransferase KAT6A OS=Homo sapiens OX=9606 GN=KAT6A PE=1 SV=2" "0.011" "False" "2.075" "0" "1" "1" "1" "2004" "224.9" "5.68" "2.45" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00628, Pf01853, Pf17772, Pf21524" "7994" "ENSG00000083168" "KAT6A" "hsa:7994; Q76L81; Q92794" "Pathways affected in adenoid cystic carcinoma" "HATs acetylate histones; Regulation of TP53 Activity through Acetylation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4676575217961373957" "False" "Medium" "IsMasterProtein" "P63098" "Calcineurin subunit B type 1 OS=Homo sapiens OX=9606 GN=PPP3R1 PE=1 SV=2" "0.011" "False" "2.072" "4" "1" "2" "1" "170" "19.3" "4.81" "5.74" "1" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13499" "5534" "ENSG00000221823" "PPP3R1" "B2RC10; B5MDU4; hsa:5534; P06705; P15117; P63098; Q08044; Q53SL0" "Energy metabolism; Transcription factors regulate miRNAs related to cardiac hypertrophy; Alzheimer's disease and miRNA effects; Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; Wnt signaling; Vitamin D in inflammatory diseases; Regucalcin in proximal tubule epithelial kidney cells; Alzheimer's disease" "FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; DARPP-32 events; Activation of BAD and translocation to mitochondria" "15" "0" "0.915" "1.007" "0.975" "0.938" "1.092" "0.961" "0.946" "0.971" "1.480" "223.9" "204.9" "225.5" "218.3" "210.0" "244.5" "215.0" "211.7" "217.4" "331.4" "" "" "" "" "" "" "" "" "" "" "134.0" "106.5" "124.9" "102.5" "97.3" "125.2" "100.0" "95.0" "117.9" "331.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7634397569492690707" "False" "Medium" "IsMasterProtein" "Q96HY7" "2-oxoadipate dehydrogenase complex component E1 OS=Homo sapiens OX=9606 GN=DHTKD1 PE=1 SV=2" "0.011" "False" "2.071" "1" "1" "1" "1" "919" "103.0" "6.93" "2.07" "1" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00676, Pf02779, Pf16870" "55526" "ENSG00000181192" "DHTKD1" "hsa:55526; Q68CU5; Q96HY7; Q9BUM8; Q9HCE2" "" "Glyoxylate metabolism and glycine degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2108703214608144017" "False" "Medium" "IsMasterProtein" "Q7Z591" "Microtubule organization protein AKNA OS=Homo sapiens OX=9606 GN=AKNA PE=1 SV=2" "0.011" "False" "2.066" "1" "1" "1" "1" "1439" "155.0" "6.32" "0.00" "1" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf12443" "80709" "ENSG00000106948" "AKNA" "hsa:80709; Q05BK5; Q5T535; Q5T536; Q5T537; Q64FX6; Q64FX7; Q64FX8; Q64FY2; Q6ZMK0; Q6ZNL2; Q6ZTX0; Q7Z591; Q8TET1; Q8TF33; Q96RR9; Q9H7P7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "High" "High" "1" "" "3780943028693763467" "False" "Medium" "IsMasterProtein" "Q9H009" "Nascent polypeptide-associated complex subunit alpha-2 OS=Homo sapiens OX=9606 GN=NACA2 PE=1 SV=1" "0.011" "False" "2.062" "4" "1" "2" "1" "215" "23.2" "4.73" "1.63" "1" "other biological processes" "translational apparatus;nucleus;other cell component" "other molecular function" "Pf01849, Pf19026" "342538" "ENSG00000253506" "NACA2" "hsa:342538; Q2VIR9; Q9H009" "" "" "0" "0" "0.850" "1.076" "1.515" "0.945" "1.147" "1.360" "0.785" "1.191" "1.320" "17.6" "14.9" "18.9" "26.6" "16.6" "20.2" "23.9" "13.8" "20.9" "23.2" "" "" "" "" "" "" "" "" "" "" "10.5" "7.8" "10.5" "12.5" "7.7" "10.3" "11.1" "6.2" "11.4" "23.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7104112355135180301" "False" "Medium" "IsMasterProtein" "Q9UL26" "Ras-related protein Rab-22A OS=Homo sapiens OX=9606 GN=RAB22A PE=1 SV=2" "0.011" "False" "2.057" "6" "1" "3" "1" "194" "21.8" "8.15" "0.00" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "57403" "ENSG00000124209" "RAB22A" "B3KR86; E1P605; hsa:57403; Q8TF12; Q9H4E6; Q9UL26" "" "RAB geranylgeranylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4186316132273188222" "False" "Medium" "IsMasterProtein" "Q92538" "Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=GBF1 PE=1 SV=3" "0.011" "False" "2.053" "0" "1" "1" "1" "1860" "206.4" "5.73" "2.01" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf01369, Pf12783" "8729" "ENSG00000107862" "GBF1" "A0A7P0RGV0; hsa:8729; Q149P0; Q149P1; Q5VXX3; Q92538; Q96CK6; Q96HZ3; Q9H473" "" "VxPx cargo-targeting to cilium; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; trans-Golgi Network Vesicle Budding" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3570243634590463313" "False" "Medium" "IsMasterProtein" "Q86XI8" "Uncharacterized protein ZSWIM9 OS=Homo sapiens OX=9606 GN=ZSWIM9 PE=1 SV=2" "0.012" "False" "2.050" "1" "1" "3" "1" "627" "70.0" "8.57" "7.05" "1" "" "" "" "Pf17738, Pf20783, Pf20784" "374920" "ENSG00000185453" "ZSWIM9" "A0A087WWL5; hsa:374920; Q86XI8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7262378899326464303" "False" "Medium" "IsMasterProtein" "Q9BRX5" "DNA replication complex GINS protein PSF3 OS=Homo sapiens OX=9606 GN=GINS3 PE=1 SV=1" "0.012" "False" "2.048" "4" "1" "1" "1" "216" "24.5" "5.34" "1.84" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "nucleus" "" "Pf05916" "64785" "ENSG00000181938" "GINS3" "B2RDP3; E9PB21; hsa:64785; Q9BRX5; Q9H870" "" "Unwinding of DNA" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "487381900913570393" "False" "Medium" "IsMasterProtein" "Q9H8Y8" "Golgi reassembly-stacking protein 2 OS=Homo sapiens OX=9606 GN=GORASP2 PE=1 SV=3" "0.012" "False" "2.048" "2" "1" "1" "1" "452" "47.1" "4.82" "2.93" "1" "cell organization and biogenesis;stress response;other biological processes" "other membranes;ER/Golgi" "" "Pf04495" "26003" "ENSG00000115806" "GORASP2" "B4DKT0; hsa:26003; Q53TE3; Q96I74; Q96K84; Q9H8Y8; Q9H946; Q9UFW4" "" "Golgi Cisternae Pericentriolar Stack Reorganization" "1" "0" "1.754" "1.597" "1.259" "1.335" "1.243" "1.367" "1.413" "1.397" "2.532" "49.2" "86.3" "78.5" "61.9" "65.7" "61.1" "67.3" "69.5" "68.7" "124.5" "" "" "" "" "" "" "" "" "" "" "29.4" "44.8" "43.5" "29.1" "30.4" "31.3" "31.3" "31.2" "37.3" "124.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6342560622817440014" "False" "Medium" "IsMasterProtein" "Q96PU8" "KH domain-containing RNA-binding protein QKI OS=Homo sapiens OX=9606 GN=QKI PE=1 SV=1" "0.012" "False" "2.041" "2" "1" "1" "1" "341" "37.6" "8.56" "2.07" "1" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf16544, Pf16551" "9444" "ENSG00000112531" "QKI" "hsa:9444; Q2I375; Q5MJQ1; Q969L9; Q96EJ3; Q96KA3; Q96PU6; Q96PU7; Q96PU8; Q9P0X6; Q9P0X7; Q9P0X8; Q9P0X9; Q9P0Y0; Q9P0Y1" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation" "Signaling by BRAF and RAF1 fusions" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8300178027695563917" "False" "Medium" "IsMasterProtein" "P34059" "N-acetylgalactosamine-6-sulfatase OS=Homo sapiens OX=9606 GN=GALNS PE=1 SV=1" "0.012" "False" "2.041" "2" "1" "1" "1" "522" "58.0" "6.74" "2.44" "1" "" "non-structural extracellular;other cytoplasmic organelle" "other molecular function" "Pf00884, Pf14707" "2588" "ENSG00000141012" "GALNS" "hsa:2588; P34059; Q86VK3" "Glycosaminoglycan degradation" "Neutrophil degranulation; Keratan sulfate degradation; MPS IV - Morquio syndrome A" "4" "0" "0.856" "0.936" "1.003" "0.979" "0.799" "1.062" "0.777" "1.054" "0.657" "92.4" "79.1" "86.5" "92.7" "90.4" "73.8" "98.1" "71.8" "97.4" "60.7" "" "" "" "" "" "" "" "" "" "" "55.3" "41.1" "47.9" "43.5" "41.9" "37.8" "45.6" "32.2" "52.9" "60.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2311185762453524816" "False" "Medium" "IsMasterProtein" "O95905" "Protein ecdysoneless homolog OS=Homo sapiens OX=9606 GN=ECD PE=1 SV=1" "0.012" "False" "2.036" "1" "1" "1" "1" "644" "72.7" "4.87" "2.15" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07093" "11319" "ENSG00000122882" "ECD" "C9JX46; E9PAW8; hsa:11319; O95905" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5489281537849050427" "False" "Medium" "IsMasterProtein" "Q9UEU0" "Vesicle transport through interaction with t-SNAREs homolog 1B OS=Homo sapiens OX=9606 GN=VTI1B PE=1 SV=3" "0.012" "False" "2.035" "5" "1" "1" "1" "232" "26.7" "9.04" "0.00" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05008, Pf12352" "10490" "ENSG00000100568" "VTI1B" "hsa:10490; O43547; Q96J28; Q9UEU0" "" "Platelet degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5268900827420386620" "False" "Medium" "IsMasterProtein" "Q96N46" "Tetratricopeptide repeat protein 14 OS=Homo sapiens OX=9606 GN=TTC14 PE=1 SV=1" "0.012" "False" "2.035" "2" "1" "1" "1" "770" "88.3" "8.63" "0.00" "1" "" "" "nucleic acid binding activity" "Pf13414" "151613" "ENSG00000163728" "TTC14" "G5E9X0; hsa:151613; Q6UWJ7; Q8TF22; Q96N46" "Ectoderm differentiation; Ectoderm differentiation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2095194651549531862" "False" "Medium" "IsMasterProtein" "O95487" "Protein transport protein Sec24B OS=Homo sapiens OX=9606 GN=SEC24B PE=1 SV=2" "0.012" "False" "2.032" "1" "1" "1" "1" "1268" "137.3" "6.67" "0.00" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10427" "ENSG00000138802" "SEC24B" "B7ZKM8; B7ZKN4; hsa:10427; O95487; Q0VG08" "Sterol regulatory element-binding proteins (SREBP) signaling" "COPII-mediated vesicle transport; MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "7" "0" "0.765" "0.988" "0.873" "0.835" "1.045" "0.832" "0.341" "1.126" "4.038" "17.8" "13.6" "17.6" "15.5" "14.9" "18.6" "14.8" "6.1" "20.0" "71.9" "" "" "" "" "" "" "" "" "" "" "10.7" "7.1" "9.7" "7.3" "6.9" "9.5" "6.9" "2.7" "10.9" "71.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8015084779346645449" "False" "Medium" "IsMasterProtein" "Q8IY34" "Solute carrier family 15 member 3 OS=Homo sapiens OX=9606 GN=SLC15A3 PE=1 SV=2" "0.012" "False" "2.024" "2" "1" "1" "1" "581" "63.5" "9.06" "0.00" "1" "stress response;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "transporter activity" "Pf00854" "51296" "ENSG00000110446" "SLC15A3" "hsa:51296; Q8IY34; Q9P2X9" "" "Proton/oligopeptide cotransporters" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8207864549745438201" "False" "Medium" "IsMasterProtein" "Q96T76" "MMS19 nucleotide excision repair protein homolog OS=Homo sapiens OX=9606 GN=MMS19 PE=1 SV=2" "0.012" "False" "2.021" "1" "1" "1" "1" "1030" "113.2" "6.35" "2.50" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf12460, Pf14500" "64210" "ENSG00000155229" "MMS19" "B0QZ75; B3KPE5; B4DQX2; B4E2I3; D3DR55; F8W9Y2; hsa:64210; Q17RZ8; Q5T455; Q66K82; Q7L4W8; Q969Z1; Q96DF1; Q96MR1; Q96RK5; Q96SK1; Q96T76; Q9BUE2; Q9BYS9" "2q11.2 copy number variation syndrome" "Cytosolic iron-sulfur cluster assembly" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4732323992224053242" "False" "Medium" "IsMasterProtein" "Q9NU22" "Midasin OS=Homo sapiens OX=9606 GN=MDN1 PE=1 SV=2" "0.012" "False" "2.021" "0" "1" "1" "1" "5596" "632.4" "5.68" "0.00" "1" "cell organization and biogenesis;transport" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07728, Pf17865, Pf17867, Pf21108" "23195" "ENSG00000112159" "MDN1" "hsa:23195; O15019; Q5T794; Q9NU22" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4733081690105890722" "False" "Medium" "IsMasterProtein" "Q9UKN8" "General transcription factor 3C polypeptide 4 OS=Homo sapiens OX=9606 GN=GTF3C4 PE=1 SV=2" "0.012" "False" "2.020" "2" "1" "1" "1" "822" "91.9" "6.65" "1.62" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf12657, Pf12660, Pf19336" "9329" "ENSG00000125484" "GTF3C4" "hsa:9329; Q5VZJ7; Q9UKN8" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "3" "0" "1.146" "1.195" "1.166" "1.197" "0.991" "1.218" "0.838" "1.250" "3.737" "112.8" "129.2" "134.7" "131.5" "135.0" "111.7" "137.3" "94.5" "141.0" "421.4" "" "" "" "" "" "" "" "" "" "" "67.5" "67.1" "74.6" "61.8" "62.6" "57.2" "63.9" "42.4" "76.5" "421.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7300234986245447524" "False" "Medium" "IsMasterProtein" "Cont_P01045" "Kininogen-2 OS=Bos taurus OX=9913 GN=KNG2 PE=1 SV=1" "0.012" "True" "2.019" "1" "1" "1" "1" "619" "68.7" "6.57" "3.40" "1" "stress response;other biological processes" "non-structural extracellular" "enzyme regulator activity" "Pf00031" "280833" "" "KNG2" "bta:280833; P01045; P01047" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6945972540220555835" "False" "Medium" "IsMasterProtein" "Q96ST3" "Paired amphipathic helix protein Sin3a OS=Homo sapiens OX=9606 GN=SIN3A PE=1 SV=2" "0.012" "False" "2.017" "1" "1" "1" "1" "1273" "145.1" "7.25" "2.41" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02671, Pf08295, Pf16879" "25942" "ENSG00000169375" "SIN3A" "B2RNS5; Q8N8N4; Q8NC83; Q8WV18; Q96L98; Q96ST3; Q9UFQ1" "Androgen receptor signaling pathway; Retinoblastoma gene in cancer; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; Transcription co-factors SKI and SKIL protein partners; Hedgehog signaling pathway; 15q11q13 copy number variation" "Cytoprotection by HMOX1; Factors involved in megakaryocyte development and platelet production; NoRC negatively regulates rRNA expression; STAT3 nuclear events downstream of ALK signaling; Regulation of lipid metabolism by PPARalpha; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SUMOylation of transcription cofactors; MECP2 regulates transcription of neuronal ligands; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of MECP2 expression and activity; MECP2 regulates neuronal receptors and channels; Loss of MECP2 binding ability to 5mC-DNA" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "458112700230117025" "False" "Medium" "IsMasterProtein" "Q8NG06" "E3 ubiquitin-protein ligase TRIM58 OS=Homo sapiens OX=9606 GN=TRIM58 PE=1 SV=2" "0.012" "False" "2.011" "3" "1" "1" "1" "486" "54.7" "6.19" "2.13" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13765, Pf15227" "25893" "ENSG00000162722" "TRIM58" "hsa:25893; Q6B0H9; Q8NG06" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2007985770655079458" "False" "Medium" "IsMasterProtein" "Q9BPX6" "Calcium uptake protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=MICU1 PE=1 SV=1" "0.012" "False" "2.011" "2" "1" "1" "1" "476" "54.3" "8.41" "2.01" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf13202" "10367" "ENSG00000107745" "MICU1" "A8MV96; B3KN20; B4DJH9; B4DPI1; B5MBY3; D3YTJ3; hsa:10367; O75785; Q9BPX6; Q9H9N6; Q9UFX0" "" "Processing of SMDT1" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2989774251317297794" "False" "Medium" "IsMasterProtein" "Q9H2G4" "Testis-specific Y-encoded-like protein 2 OS=Homo sapiens OX=9606 GN=TSPYL2 PE=1 SV=1" "0.012" "False" "2.010" "2" "1" "1" "1" "693" "79.4" "4.58" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00956" "64061" "ENSG00000184205" "TSPYL2" "hsa:64061; O94799; Q96DG7; Q9BZW6; Q9H2G4" "" "XBP1(S) activates chaperone genes" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7223228418441482962" "False" "Medium" "IsMasterProtein" "Q15648" "Mediator of RNA polymerase II transcription subunit 1 OS=Homo sapiens OX=9606 GN=MED1 PE=1 SV=4" "0.012" "False" "2.009" "1" "1" "1" "1" "1581" "168.4" "8.73" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf10744" "5469" "ENSG00000125686" "MED1" "A2RRQ6; hsa:5469; O43810; O75447; Q15648; Q6P9H7; Q6PK58; Q9HD39" "Energy metabolism; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Non-genomic actions of 1,25 dihydroxyvitamin D3; 17q12 copy number variation syndrome" "Cytoprotection by HMOX1; Estrogen-dependent gene expression; PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Transcriptional activation of mitochondrial biogenesis; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nuclear Receptor transcription pathway; RORA activates gene expression" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7625852785660981987" "False" "Medium" "IsMasterProtein" "Q15126" "Phosphomevalonate kinase OS=Homo sapiens OX=9606 GN=PMVK PE=1 SV=3" "0.012" "False" "2.006" "4" "1" "1" "1" "192" "22.0" "5.73" "2.18" "1" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "kinase activity;other molecular function" "Pf04275" "10654" "ENSG00000163344" "PMVK" "Q15126; Q5TZW9" "Cholesterol biosynthesis pathway; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "8" "0" "0.997" "1.259" "1.297" "0.809" "0.961" "0.881" "0.058" "1.409" "9.729" "26.3" "26.2" "33.1" "34.1" "21.3" "25.3" "23.2" "1.5" "37.1" "255.8" "" "" "" "" "" "" "" "" "" "" "15.7" "13.6" "18.3" "16.0" "9.9" "12.9" "10.8" "0.7" "20.1" "255.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7563735417890983721" "False" "Medium" "IsMasterProtein" "P41208" "Centrin-2 OS=Homo sapiens OX=9606 GN=CETN2 PE=1 SV=1" "0.012" "False" "2.002" "4" "1" "1" "1" "172" "19.7" "5.00" "2.39" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf13499" "1069" "ENSG00000147400; ENSG00000292191" "CETN2" "B2R4T4; hsa:1069; P41208; Q53XW1" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Recruitment of NuMA to mitotic centrosomes; SUMOylation of DNA damage response and repair proteins; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2882906632265539377" "False" "Medium" "IsMasterProtein" "Q9NQV6" "PR domain zinc finger protein 10 OS=Homo sapiens OX=9606 GN=PRDM10 PE=1 SV=3" "0.012" "False" "2.002" "1" "1" "1" "1" "1147" "130.1" "6.74" "2.18" "1" "other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf12874, Pf21549" "56980" "ENSG00000170325" "PRDM10" "B7ZL71; G3XAE5; hsa:56980; J3KP23; Q17R90; Q2KHR4; Q863Z2; Q9NQV6; Q9NXI4; Q9ULI9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3564377166653415060" "False" "Medium" "IsMasterProtein" "Q5JS54" "Proteasome assembly chaperone 4 OS=Homo sapiens OX=9606 GN=PSMG4 PE=1 SV=2" "0.012" "False" "1.996" "7" "1" "2" "1" "123" "13.8" "6.52" "1.85" "1" "cell organization and biogenesis" "other cell component" "other molecular function" "Pf16093" "389362" "ENSG00000180822" "PSMG4" "C9J2F8; F8WBZ2; hsa:389362; Q5JS53; Q5JS54; Q5JS56" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8599582728715422228" "False" "Medium" "IsMasterProtein" "Q01432" "AMP deaminase 3 OS=Homo sapiens OX=9606 GN=AMPD3 PE=1 SV=1" "0.012" "False" "1.992" "1" "1" "1" "1" "767" "88.8" "6.98" "0.00" "1" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf19326" "272" "ENSG00000133805" "AMPD3" "A0AUX0; B7Z2S2; B7Z763; B7Z877; hsa:272; Q01432" "" "Neutrophil degranulation; Purine salvage" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7022499983038261226" "False" "Medium" "IsMasterProtein" "Q1ED39" "Lysine-rich nucleolar protein 1 OS=Homo sapiens OX=9606 GN=KNOP1 PE=1 SV=1" "0.012" "False" "1.991" "4" "1" "1" "1" "458" "51.6" "9.86" "0.00" "1" "" "nucleus" "" "Pf15477" "400506" "ENSG00000103550" "KNOP1" "O43328; Q1ED39; Q5FWF3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "Not Found" "High" "High" "High" "High" "High" "1" "" "-4782042828393349132" "False" "Medium" "IsMasterProtein" "P52756" "RNA-binding protein 5 OS=Homo sapiens OX=9606 GN=RBM5 PE=1 SV=2" "0.012" "False" "1.989" "1" "1" "1" "1" "815" "92.1" "6.28" "1.61" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641, Pf01585, Pf17780" "10181" "ENSG00000003756" "RBM5" "B2RA45; B4DM16; B4DMF9; B4DZ63; hsa:10181; P52756; Q93021; Q9BU14; Q9HDA6; Q9UKY8; Q9UL24" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9158641874839162528" "False" "Medium" "IsMasterProtein" "Q5JYT7" "Uncharacterized protein KIAA1755 OS=Homo sapiens OX=9606 GN=KIAA1755 PE=1 SV=2" "0.012" "False" "1.986" "1" "1" "1" "1" "1200" "130.8" "6.37" "2.39" "1" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity" "" "85449" "ENSG00000149633" "KIAA1755" "Q5JYT7; Q9C0A8" "" "" "0" "0" "1.035" "1.089" "0.936" "0.824" "0.799" "1.084" "0.924" "1.074" "0.671" "281.6" "291.5" "306.8" "263.5" "232.0" "225.1" "305.3" "260.1" "302.5" "189.0" "" "" "" "" "" "" "" "" "" "" "168.5" "151.5" "169.9" "123.7" "107.5" "115.2" "141.9" "116.8" "164.1" "189.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1072346070458958756" "False" "Medium" "IsMasterProtein" "Q8N2H3" "Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PYROXD2 PE=1 SV=2" "0.012" "False" "1.978" "1" "1" "1" "1" "581" "63.0" "6.95" "0.00" "1" "cell organization and biogenesis" "mitochondrion" "other molecular function" "Pf01593, Pf13450" "84795" "ENSG00000119943" "PYROXD2" "D3DR61; hsa:84795; Q5TAA9; Q8N2H3; Q9BRQ1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3969710029576412220" "False" "Medium" "IsMasterProtein" "Q9Y3T6" "R3H and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=R3HCC1 PE=1 SV=3" "0.012" "False" "1.977" "2" "1" "1" "1" "440" "49.1" "5.63" "0.00" "1" "" "" "nucleic acid binding activity" "Pf01424" "203069" "ENSG00000104679" "R3HCC1" "B7ZLI1; hsa:203069; Q9Y3T6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6706033477145549001" "False" "Medium" "IsMasterProtein" "A7XYQ1" "Sine oculis-binding protein homolog OS=Homo sapiens OX=9606 GN=SOBP PE=1 SV=2" "0.012" "False" "1.974" "1" "1" "1" "1" "873" "92.6" "7.68" "1.84" "1" "developmental processes;other biological processes" "nucleus" "other molecular function" "Pf15279" "55084" "ENSG00000112320" "SOBP" "A7XYQ1; B0QZ12; hsa:55084; Q5BJD4; Q8N2B2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1415915778275113183" "False" "Medium" "IsMasterProtein" "Q7L273" "BTB/POZ domain-containing protein KCTD9 OS=Homo sapiens OX=9606 GN=KCTD9 PE=1 SV=1" "0.012" "False" "1.974" "3" "1" "1" "1" "389" "42.5" "6.37" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction" "" "other molecular function" "Pf00805, Pf02214, Pf11834" "54793" "ENSG00000104756" "KCTD9" "hsa:54793; Q6NUM8; Q7L273; Q9NXV4" "" "" "0" "0" "1.079" "1.507" "1.522" "0.914" "1.274" "1.376" "1.651" "1.421" "0.678" "21.7" "23.4" "32.7" "33.0" "19.8" "27.6" "29.8" "35.8" "30.8" "14.7" "" "" "" "" "" "" "" "" "" "" "13.0" "12.1" "18.1" "15.5" "9.2" "14.1" "13.9" "16.1" "16.7" "14.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2429714834335380006" "False" "Medium" "IsMasterProtein" "P40818" "Ubiquitin carboxyl-terminal hydrolase 8 OS=Homo sapiens OX=9606 GN=USP8 PE=1 SV=1" "0.012" "False" "1.974" "1" "1" "1" "1" "1118" "127.4" "8.51" "1.75" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00443, Pf00581, Pf08969, Pf20625" "9101" "ENSG00000138592" "USP8" "B4DKA8; hsa:9101; P40818; Q2TB31; Q7Z3U2; Q86VA0; Q8IWI7" "EGF/EGFR signaling pathway; Male infertility" "Ub-specific processing proteases; Negative regulation of MET activity; Downregulation of ERBB2:ERBB3 signaling; Regulation of FZD by ubiquitination" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "524672605360435536" "False" "Medium" "IsMasterProtein" "O95273" "Cyclin-D1-binding protein 1 OS=Homo sapiens OX=9606 GN=CCNDBP1 PE=1 SV=2" "0.013" "False" "1.973" "3" "1" "1" "1" "360" "40.2" "4.82" "2.20" "1" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "" "Pf13324, Pf20936" "23582" "ENSG00000166946" "CCNDBP1" "A8K3Q0; A8K3U2; hsa:23582; O95273; Q6ZQN9; Q7Z519; Q8NBS7; Q8NBY2; Q9NS19; Q9NYH3; Q9UHX9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4301094259953391883" "False" "Medium" "IsMasterProtein" "Q86VZ1" "P2Y purinoceptor 8 OS=Homo sapiens OX=9606 GN=P2RY8 PE=1 SV=1" "0.013" "False" "1.961" "6" "1" "1" "1" "359" "40.6" "9.50" "0.00" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00001" "286530" "ENSG00000182162; ENSG00000292333" "P2RY8" "hsa:286530; Q86VZ1" "Purinergic signaling" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8444524107574200916" "False" "Medium" "IsMasterProtein" "Q9UH73" "Transcription factor COE1 OS=Homo sapiens OX=9606 GN=EBF1 PE=1 SV=2" "0.013" "False" "1.960" "1" "1" "1" "1" "591" "64.4" "8.76" "1.78" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01833, Pf16422, Pf16423" "1879" "ENSG00000164330" "EBF1" "hsa:1879; Q8IW11; Q9UH73" "Adipogenesis; Prion disease pathway; White fat cell differentiation" "Transcriptional regulation of white adipocyte differentiation; Expression and translocation of olfactory receptors" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6107104793922959907" "False" "Medium" "IsMasterProtein" "O94832" "Unconventional myosin-Id OS=Homo sapiens OX=9606 GN=MYO1D PE=1 SV=2" "0.014" "False" "1.953" "1" "1" "3" "1" "1006" "116.1" "9.39" "8.03" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf06017" "4642" "ENSG00000176658" "MYO1D" "A6H8V3; hsa:4642; O94832; Q8NHP9" "" "" "0" "0" "1.135" "0.966" "0.920" "1.003" "1.104" "1.177" "1.078" "0.918" "0.333" "142.1" "161.2" "137.2" "130.7" "142.5" "156.9" "167.2" "153.2" "130.4" "47.3" "" "" "" "" "" "" "" "" "" "" "85.0" "83.8" "76.0" "61.3" "66.1" "80.3" "77.8" "68.8" "70.7" "47.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8590032029601755120" "False" "Medium" "IsMasterProtein" "O75935" "Dynactin subunit 3 OS=Homo sapiens OX=9606 GN=DCTN3 PE=1 SV=1" "0.014" "False" "1.951" "5" "1" "1" "1" "186" "21.1" "5.47" "1.98" "1" "cell cycle OR cell proliferation;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07426" "11258" "ENSG00000137100" "DCTN3" "A6NII7; B2RBM5; hsa:11258; O75935; Q5T1I5; Q5T1I7; Q5T8G3; Q9BPU8" "" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "11" "0" "1.010" "0.810" "0.887" "0.961" "1.158" "1.197" "1.307" "1.092" "3.195" "33.3" "33.7" "27.0" "29.6" "32.0" "38.6" "39.9" "43.6" "36.4" "106.5" "" "" "" "" "" "" "" "" "" "" "19.9" "17.5" "14.9" "13.9" "14.8" "19.8" "18.6" "19.6" "19.7" "106.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3365400803270847395" "False" "Medium" "IsMasterProtein" "Q8N6F7" "Germinal center-associated signaling and motility protein OS=Homo sapiens OX=9606 GN=GCSAM PE=1 SV=1" "0.014" "False" "1.950" "12" "1" "1" "1" "178" "21.0" "6.52" "0.00" "1" "other biological processes" "plasma membrane;other membranes;other cell component" "cytoskeletal activity;other molecular function" "Pf15666" "257144" "ENSG00000174500; ENSG00000284925" "GCSAM" "C9JD17; C9JUG6; hsa:257144; Q8N6F7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "Not Found" "Not Found" "High" "High" "High" "1" "" "-8139328666383470964" "False" "Medium" "IsMasterProtein" "Q8IZH2" "5'-3' exoribonuclease 1 OS=Homo sapiens OX=9606 GN=XRN1 PE=1 SV=1" "0.014" "False" "1.948" "1" "1" "1" "1" "1706" "194.0" "7.21" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03159, Pf17846, Pf18129, Pf18332, Pf18334" "54464" "ENSG00000114127" "XRN1" "hsa:54464; Q4G0S3; Q68D88; Q6AI24; Q6MZS8; Q86WS7; Q8IZH2; Q8N8U4; Q9UF39" "miRNA degrading enzymes" "mRNA decay by 5' to 3' exoribonuclease; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2848165254260814565" "False" "Medium" "IsMasterProtein" "Q6ZQQ2" "Spermatogenesis-associated protein 31D1 OS=Homo sapiens OX=9606 GN=SPATA31D1 PE=1 SV=1" "0.014" "False" "1.947" "1" "1" "1" "1" "1576" "175.5" "8.85" "2.03" "1" "other biological processes" "other membranes" "" "Pf14650, Pf15371" "389763" "ENSG00000214929" "SPATA31D1" "hsa:389763; Q6ZQQ2" "" "" "0" "0" "0.881" "0.833" "0.992" "0.740" "0.754" "0.737" "1.029" "0.894" "0.388" "65.9" "58.1" "54.9" "65.4" "48.8" "49.7" "48.6" "67.9" "59.0" "25.6" "" "" "" "" "" "" "" "" "" "" "39.5" "30.2" "30.4" "30.7" "22.6" "25.4" "22.6" "30.5" "32.0" "25.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1107540500627023376" "False" "Medium" "IsMasterProtein" "Q96EE3" "Nucleoporin SEH1 OS=Homo sapiens OX=9606 GN=SEH1L PE=1 SV=3" "0.014" "False" "1.947" "2" "1" "1" "1" "360" "39.6" "8.09" "2.56" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "81929" "ENSG00000085415" "SEH1L" "A8K5B1; hsa:81929; Q8NFU6; Q96EE3; Q96MH3; Q9C069" "" "Amino acids regulate mTORC1" "1" "0" "1.149" "1.077" "1.114" "1.107" "1.077" "1.200" "1.240" "1.242" "1.122" "176.7" "203.0" "190.3" "196.8" "195.5" "190.3" "211.9" "219.1" "219.4" "198.3" "" "" "" "" "" "" "" "" "" "" "105.7" "105.5" "105.4" "92.4" "90.6" "97.4" "98.5" "98.4" "119.0" "198.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-440443550218758408" "False" "Medium" "IsMasterProtein" "Q5JU67" "Cilia- and flagella-associated protein 157 OS=Homo sapiens OX=9606 GN=CFAP157 PE=1 SV=1" "0.014" "False" "1.945" "2" "1" "1" "1" "520" "60.5" "8.81" "0.00" "1" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "" "286207" "ENSG00000160401" "CFAP157" "A5D8T9; Q5JU67" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "Not Found" "High" "High" "High" "High" "High" "Not Found" "High" "1" "" "-8285905538601848760" "False" "Medium" "IsMasterProtein" "Q9H0E9" "Bromodomain-containing protein 8 OS=Homo sapiens OX=9606 GN=BRD8 PE=1 SV=2" "0.014" "False" "1.943" "1" "1" "1" "1" "1235" "135.3" "4.60" "2.52" "1" "cell organization and biogenesis;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00439" "10902" "ENSG00000112983" "BRD8" "hsa:10902; O43178; Q15355; Q58AB0; Q59GN0; Q969M9; Q9H0E9" "" "HATs acetylate histones" "1" "0" "0.895" "0.761" "0.911" "1.071" "1.084" "0.792" "0.893" "0.999" "1.046" "83.6" "74.8" "63.6" "76.2" "89.5" "90.6" "66.2" "74.7" "83.6" "87.5" "" "" "" "" "" "" "" "" "" "" "50.0" "38.9" "35.2" "35.8" "41.5" "46.4" "30.8" "33.5" "45.3" "87.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7682312476163043373" "False" "Medium" "IsMasterProtein" "P82914" "Small ribosomal subunit protein uS15m OS=Homo sapiens OX=9606 GN=MRPS15 PE=1 SV=1" "0.014" "False" "1.942" "3" "1" "1" "1" "257" "29.8" "10.48" "2.02" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00312" "64960" "ENSG00000116898" "MRPS15" "B2RD82; hsa:64960; P82914; Q9H2K1" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5897019344324903703" "False" "Medium" "IsMasterProtein" "Q9NP79" "Vacuolar protein sorting-associated protein VTA1 homolog OS=Homo sapiens OX=9606 GN=VTA1 PE=1 SV=1" "0.014" "False" "1.942" "3" "1" "1" "1" "307" "33.9" "6.29" "2.24" "1" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04652, Pf18097" "51534" "ENSG00000009844" "VTA1" "B4DW55; E1P594; E7ETQ7; hsa:51534; Q5TGM1; Q6IAE8; Q9H0R2; Q9H3K9; Q9NP79; Q9P0Q0" "" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4054510205684443302" "False" "Medium" "IsMasterProtein" "Q9Y6X8" "Zinc fingers and homeoboxes protein 2 OS=Homo sapiens OX=9606 GN=ZHX2 PE=1 SV=1" "0.014" "False" "1.940" "1" "1" "1" "1" "837" "92.3" "6.86" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf18387" "22882" "ENSG00000178764" "ZHX2" "hsa:22882; Q9Y6X8" "" "" "0" "0" "0.904" "1.128" "1.176" "1.124" "1.179" "0.960" "0.616" "0.866" "3.305" "21.1" "19.1" "23.8" "24.8" "23.8" "24.9" "20.3" "13.0" "18.3" "69.8" "" "" "" "" "" "" "" "" "" "" "12.6" "9.9" "13.2" "11.7" "11.0" "12.8" "9.4" "5.8" "9.9" "69.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7212838211136634633" "False" "Medium" "IsMasterProtein" "Q9NYY8" "FAST kinase domain-containing protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=FASTKD2 PE=1 SV=1" "0.014" "False" "1.937" "2" "1" "1" "1" "710" "81.4" "8.05" "1.84" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "nucleic acid binding activity" "Pf06743, Pf08368, Pf08373" "22868" "ENSG00000118246" "FASTKD2" "hsa:22868; Q9NVX6; Q9NYY8; Q9Y2H7" "" "FASTK family proteins regulate processing and stability of mitochondrial RNAs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7162777822988383217" "False" "Medium" "IsMasterProtein" "A0AAG2TU83" "Uncharacterized protein OS=Homo sapiens OX=9606 PE=4 SV=1" "0.014" "False" "1.937" "10" "1" "1" "1" "120" "13.7" "9.38" "2.09" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "1.074" "1.342" "1.056" "1.884" "1.184" "1.311" "1.192" "1.081" "0.876" "21.5" "23.1" "28.8" "22.7" "40.5" "25.4" "28.2" "25.6" "23.2" "18.8" "" "" "" "" "" "" "" "" "" "" "12.9" "12.0" "16.0" "10.6" "18.8" "13.0" "13.1" "11.5" "12.6" "18.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7454062146017555339" "False" "Medium" "IsMasterProtein" "P32019" "Type II inositol 1,4,5-trisphosphate 5-phosphatase OS=Homo sapiens OX=9606 GN=INPP5B PE=1 SV=4" "0.014" "False" "1.936" "1" "1" "1" "1" "993" "112.8" "5.57" "2.73" "1" "other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00620, Pf16776, Pf21310" "3633" "ENSG00000204084" "INPP5B" "C9J6U5; hsa:3633; P32019; Q5VSG9; Q5VSH0; Q5VSH1; Q658Q5; Q6P6D4; Q6PD53; Q86YE1" "" "Synthesis of IP2, IP, and Ins in the cytosol; Synthesis of IP3 and IP4 in the cytosol" "2" "0" "0.949" "0.887" "0.878" "1.219" "0.996" "1.078" "0.550" "0.878" "3.080" "79.4" "75.3" "70.4" "69.6" "96.7" "79.1" "85.5" "43.7" "69.7" "244.4" "" "" "" "" "" "" "" "" "" "" "47.5" "39.1" "39.0" "32.7" "44.8" "40.5" "39.8" "19.6" "37.8" "244.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8184976527645465360" "False" "Medium" "IsMasterProtein" "Q8N5M4" "Tetratricopeptide repeat protein 9C OS=Homo sapiens OX=9606 GN=TTC9C PE=1 SV=1" "0.014" "False" "1.933" "5" "1" "1" "1" "171" "20.0" "8.92" "1.60" "1" "" "" "" "Pf14559" "283237" "ENSG00000162222" "TTC9C" "hsa:283237; Q8N5M4; Q8WYY7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4617078502424805251" "False" "Medium" "IsMasterProtein" "Q9H857" "5'-nucleotidase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NT5DC2 PE=1 SV=1" "0.014" "False" "1.931" "2" "1" "1" "1" "520" "60.7" "6.77" "1.66" "1" "" "" "other molecular function" "Pf05761" "64943" "ENSG00000168268" "NT5DC2" "C9JTZ6; E9PAL9; hsa:64943; O95888; Q96C80; Q9H857; Q9H9Z8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1009047956554057166" "False" "Medium" "IsMasterProtein" "Q12756" "Kinesin-like protein KIF1A OS=Homo sapiens OX=9606 GN=KIF1A PE=1 SV=2" "0.014" "False" "1.924" "1" "1" "1" "1" "1690" "190.9" "6.21" "3.02" "1" "transport;other biological processes" "other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00225, Pf00498, Pf12423, Pf12473, Pf16183" "547" "ENSG00000130294" "KIF1A" "B0I1S5; F5H045; hsa:547; O95068; Q12756; Q13355; Q14752; Q2NKJ6; Q4LE42; Q53T78; Q59GH1; Q63Z40; Q6P1R9; Q7KZ57" "2q37 copy number variation syndrome" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "3" "0" "1.059" "1.036" "1.136" "1.084" "1.221" "0.969" "1.155" "0.994" "0.849" "85.7" "90.8" "88.8" "97.4" "92.9" "104.7" "83.0" "99.0" "85.2" "72.8" "" "" "" "" "" "" "" "" "" "" "51.3" "47.2" "49.2" "45.7" "43.1" "53.6" "38.6" "44.5" "46.2" "72.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3069559242831628546" "False" "Medium" "IsMasterProtein" "Q7Z460" "CLIP-associating protein 1 OS=Homo sapiens OX=9606 GN=CLASP1 PE=1 SV=1" "0.014" "False" "1.921" "1" "1" "1" "1" "1538" "169.3" "9.03" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf02985, Pf12348, Pf21040" "23332" "ENSG00000074054" "CLASP1" "A2RU21; B7ZLX3; F5GWS0; hsa:23332; O75118; Q2KHQ9; Q5H9P0; Q7Z460; Q8N5B8; Q9BQT5" "Microtubule cytoskeleton regulation; Splicing factor NOVA regulated synaptic proteins; 7q11.23 copy number variation syndrome" "Separation of Sister Chromatids; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Role of ABL in ROBO-SLIT signaling" "17" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "High" "Not Found" "High" "High" "High" "Not Found" "High" "1" "" "-8098039391314381890" "False" "Medium" "IsMasterProtein" "Q92503" "SEC14-like protein 1 OS=Homo sapiens OX=9606 GN=SEC14L1 PE=1 SV=2" "0.014" "False" "1.921" "2" "1" "1" "1" "715" "81.2" "6.43" "0.00" "1" "stress response;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00650, Pf03765, Pf04707" "6397" "ENSG00000129657" "SEC14L1" "A8K4E8; B4DDI5; D5G3K1; hsa:6397; Q92503; Q99780" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3994856410542386969" "False" "Medium" "IsMasterProtein" "Q9BW92" "Threonine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=TARS2 PE=1 SV=1" "0.014" "False" "1.920" "1" "1" "1" "1" "718" "81.0" "7.30" "1.74" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00587, Pf02824, Pf03129, Pf07973" "80222" "ENSG00000143374" "TARS2" "hsa:80222; Q53GW7; Q96I50; Q9BW92; Q9H9V2" "" "Mitochondrial tRNA aminoacylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5564485370032939878" "False" "Medium" "IsMasterProtein" "Q9UBV8" "Peflin OS=Homo sapiens OX=9606 GN=PEF1 PE=1 SV=1" "0.014" "False" "1.919" "4" "1" "1" "1" "284" "30.4" "6.54" "0.00" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf13405, Pf13499" "553115" "ENSG00000162517" "PEF1" "hsa:553115; Q9UBV8" "" "" "0" "0" "1.170" "1.255" "1.425" "1.173" "1.412" "1.484" "1.281" "1.729" "1.646" "39.4" "46.1" "49.5" "56.2" "46.2" "55.7" "58.5" "50.5" "68.2" "64.9" "" "" "" "" "" "" "" "" "" "" "23.6" "24.0" "27.4" "26.4" "21.4" "28.5" "27.2" "22.7" "37.0" "64.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4334840059881177708" "False" "Medium" "IsMasterProtein" "Q16864" "V-type proton ATPase subunit F OS=Homo sapiens OX=9606 GN=ATP6V1F PE=1 SV=2" "0.014" "False" "1.916" "8" "1" "1" "1" "119" "13.4" "5.52" "1.87" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "transporter activity" "Pf01990" "9296" "ENSG00000128524" "ATP6V1F" "C9J2K4; hsa:9296; Q16864; Q6IBA8" "Proximal tubule transport" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3445317151605985554" "False" "Medium" "IsMasterProtein" "Q13356" "RING-type E3 ubiquitin-protein ligase PPIL2 OS=Homo sapiens OX=9606 GN=PPIL2 PE=1 SV=1" "0.014" "False" "1.910" "2" "1" "1" "1" "520" "58.8" "8.78" "1.85" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00160" "23759" "ENSG00000100023" "PPIL2" "Q13356; Q13357; Q8TAH2; Q9BWR8" "" "mRNA Splicing - Major Pathway; Basigin interactions" "2" "0" "0.891" "0.704" "0.771" "0.819" "0.760" "1.116" "0.743" "0.877" "2.045" "39.1" "34.9" "27.5" "30.2" "32.0" "29.7" "43.7" "29.0" "34.3" "80.0" "" "" "" "" "" "" "" "" "" "" "23.4" "18.1" "15.2" "14.2" "14.8" "15.2" "20.3" "13.0" "18.6" "80.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4833474538863443704" "False" "Medium" "IsMasterProtein" "Q9NXZ2" "Probable ATP-dependent RNA helicase DDX43 OS=Homo sapiens OX=9606 GN=DDX43 PE=1 SV=2" "0.014" "False" "1.910" "2" "1" "1" "1" "648" "72.8" "8.75" "1.81" "1" "" "" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00270, Pf00271" "55510" "ENSG00000080007" "DDX43" "B4E0C8; hsa:55510; Q6NXR1; Q9NXZ2" "" "" "0" "0" "1.099" "0.767" "1.041" "1.037" "1.000" "0.950" "1.183" "0.779" "0.729" "81.8" "89.9" "62.7" "85.1" "84.8" "81.7" "77.7" "96.7" "63.7" "59.6" "" "" "" "" "" "" "" "" "" "" "48.9" "46.7" "34.7" "40.0" "39.3" "41.8" "36.1" "43.4" "34.6" "59.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93736052394886069" "False" "Medium" "IsMasterProtein" "P50583" "Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] OS=Homo sapiens OX=9606 GN=NUDT2 PE=1 SV=3" "0.014" "False" "1.896" "5" "1" "1" "1" "147" "16.8" "5.35" "2.55" "1" "other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf00293" "318" "ENSG00000164978" "NUDT2" "D3DRM0; hsa:318; P50583; Q5T589" "" "Detoxification of Reactive Oxygen Species" "1" "0" "0.982" "1.056" "1.202" "1.187" "1.106" "1.153" "0.896" "1.281" "3.098" "82.4" "80.9" "87.0" "99.0" "97.8" "91.1" "95.0" "73.8" "105.6" "255.3" "" "" "" "" "" "" "" "" "" "" "49.3" "42.0" "48.2" "46.5" "45.3" "46.6" "44.2" "33.1" "57.3" "255.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7857445100061984594" "False" "Medium" "IsMasterProtein" "Q8WVY7" "Ubiquitin-like domain-containing CTD phosphatase 1 OS=Homo sapiens OX=9606 GN=UBLCP1 PE=1 SV=2" "0.014" "False" "1.886" "3" "1" "2" "1" "318" "36.8" "6.46" "0.00" "1" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00240, Pf03031" "134510" "ENSG00000164332" "UBLCP1" "D3DQJ7; hsa:134510; Q8WVY7; Q96DK5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1268754787209103028" "False" "Medium" "IsMasterProtein" "O14795" "Protein unc-13 homolog B OS=Homo sapiens OX=9606 GN=UNC13B PE=1 SV=2" "0.014" "False" "1.881" "1" "1" "1" "1" "1591" "180.6" "5.99" "0.00" "1" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00130, Pf00168, Pf06292" "10497" "ENSG00000198722" "UNC13B" "hsa:10497; O14795; Q2NKJ5; Q5VYM8" "Synaptic vesicle pathway; 16p11.2 proximal deletion syndrome; Monoamine transport" "Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7945611468628581935" "False" "Medium" "IsMasterProtein" "Q96I25" "Splicing factor 45 OS=Homo sapiens OX=9606 GN=RBM17 PE=1 SV=1" "0.014" "False" "1.875" "2" "1" "1" "1" "401" "44.9" "5.97" "1.75" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf01585" "84991" "ENSG00000134453" "RBM17" "hsa:84991; Q96GY6; Q96I25" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1978965257736533934" "False" "Medium" "IsMasterProtein" "Q9NYK5" "Large ribosomal subunit protein mL39 OS=Homo sapiens OX=9606 GN=MRPL39 PE=1 SV=3" "0.014" "False" "1.873" "3" "1" "1" "1" "338" "38.7" "7.65" "0.00" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "" "54148" "ENSG00000154719" "MRPL39" "C9JYA5; hsa:54148; Q32Q74; Q5QTR3; Q96Q65; Q9BSQ7; Q9BZV6; Q9NX44; Q9NYK5" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.794" "1.141" "0.891" "1.961" "1.797" "1.257" "0.696" "1.309" "4.493" "15.4" "27.7" "17.6" "13.8" "30.3" "27.8" "19.4" "10.8" "20.2" "69.4" "" "" "" "" "" "" "" "" "" "" "9.2" "14.4" "9.8" "6.5" "14.0" "14.2" "9.0" "4.8" "11.0" "69.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2021642276248058836" "False" "Medium" "IsMasterProtein" "Q8TD30" "Alanine aminotransferase 2 OS=Homo sapiens OX=9606 GN=GPT2 PE=1 SV=1" "0.014" "False" "1.872" "2" "1" "1" "1" "523" "57.9" "7.71" "2.08" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00155" "84706" "ENSG00000166123" "GPT2" "hsa:84706; Q8N9E2; Q8TD30" "Amino acid metabolism; Amino acid metabolism pathway excerpt: histidine catabolism extension" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7155113845635909290" "False" "Medium" "IsMasterProtein" "P61601" "Neurocalcin-delta OS=Homo sapiens OX=9606 GN=NCALD PE=1 SV=2" "0.015" "False" "1.866" "4" "1" "1" "1" "193" "22.2" "5.35" "1.76" "1" "transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi" "cytoskeletal activity;other molecular function" "Pf00036, Pf13499" "83988" "ENSG00000104490" "NCALD" "hsa:83988; P29554; P61601; Q8IYC3; Q9H0W2" "" "Activation of Ca-permeable Kainate Receptor" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3992202401745413050" "False" "Medium" "IsMasterProtein" "O75044" "SLIT-ROBO Rho GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=SRGAP2 PE=1 SV=3" "0.015" "False" "1.858" "1" "1" "1" "1" "1071" "120.8" "6.70" "2.30" "1" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00611, Pf00620" "23380" "ENSG00000266028" "SRGAP2" "A2RUF3; hsa:23380; O75044" "" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases Activate Formins; RAC3 GTPase cycle; RHOF GTPase cycle; RHOU GTPase cycle; Inactivation of CDC42 and RAC1" "8" "0" "1.137" "1.002" "1.456" "1.074" "1.140" "1.051" "0.988" "0.991" "2.365" "20.0" "22.8" "20.1" "29.1" "21.5" "22.8" "21.0" "19.8" "19.8" "47.3" "" "" "" "" "" "" "" "" "" "" "12.0" "11.8" "11.1" "13.7" "10.0" "11.7" "9.8" "8.9" "10.8" "47.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1860543310075142412" "False" "Medium" "IsMasterProtein" "Q02413" "Desmoglein-1 OS=Homo sapiens OX=9606 GN=DSG1 PE=1 SV=2" "0.015" "False" "1.855" "1" "1" "1" "1" "1049" "113.7" "5.03" "0.00" "1" "cell adhesion;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00028, Pf01049" "1828" "ENSG00000134760" "DSG1" "B7Z845; hsa:1828; Q02413" "" "Neutrophil degranulation; Formation of the cornified envelope; RND2 GTPase cycle; RND3 GTPase cycle; Apoptotic cleavage of cell adhesion proteins" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2414375605373432376" "False" "Medium" "IsMasterProtein" "Q8TCU4" "Centrosome-associated protein ALMS1 OS=Homo sapiens OX=9606 GN=ALMS1 PE=1 SV=4" "0.015" "False" "1.854" "0" "1" "2" "1" "4168" "460.8" "6.28" "0.00" "1" "transport;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf15309, Pf18727" "7840" "ENSG00000116127" "ALMS1" "A0A087WZY3; hsa:7840; Q53S05; Q580Q8; Q86VP9; Q8TCU4; Q9Y4G4" "Ciliopathies; Alstrom syndrome" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8586045646890195007" "False" "Medium" "IsMasterProtein" "P20020" "Plasma membrane calcium-transporting ATPase 1 OS=Homo sapiens OX=9606 GN=ATP2B1 PE=1 SV=4" "0.015" "False" "1.853" "2" "1" "1" "1" "1220" "134.6" "5.91" "0.00" "1" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00122, Pf00689, Pf00690, Pf00702, Pf12424, Pf13246" "490" "ENSG00000070961" "ATP2B1" "hsa:490; P20020; Q12992; Q12993; Q13819; Q13820; Q13821; Q16504; Q93082" "Vitamin D receptor pathway; Splicing factor NOVA regulated synaptic proteins; Vitamin D-sensitive calcium signaling in depression; Calcium regulation in cardiac cells" "Sensory processing of sound by inner hair cells of the cochlea; Ion homeostasis; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "Not Found" "Not Found" "Not Found" "High" "Not Found" "Not Found" "High" "Not Found" "1" "" "-5845419377566949929" "False" "Medium" "IsMasterProtein" "P61077" "Ubiquitin-conjugating enzyme E2 D3 OS=Homo sapiens OX=9606 GN=UBE2D3 PE=1 SV=1" "0.015" "False" "1.849" "7" "1" "1" "1" "147" "16.7" "7.80" "1.79" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00179" "7323" "ENSG00000109332" "UBE2D3" "A6NJ93; A6NJB1; A6NM99; P47986; P61077; Q6IB88; Q6NXS4; Q8N924" "Proteasome degradation" "Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation; E3 ubiquitin ligases ubiquitinate target proteins; Peroxisomal protein import; IKK complex recruitment mediated by RIP1; Signaling by BMP; Inactivation of CSF3 (G-CSF) signaling; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "13" "0" "0.894" "0.671" "0.857" "0.717" "0.855" "0.674" "0.531" "0.697" "1.079" "78.0" "69.7" "52.3" "66.8" "55.9" "66.7" "52.5" "41.4" "54.3" "84.1" "" "" "" "" "" "" "" "" "" "" "46.7" "36.2" "29.0" "31.4" "25.9" "34.1" "24.4" "18.6" "29.5" "84.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1730131359197889533" "False" "Medium" "IsMasterProtein" "Q8IVU3" "Probable E3 ubiquitin-protein ligase HERC6 OS=Homo sapiens OX=9606 GN=HERC6 PE=1 SV=2" "0.015" "False" "1.848" "1" "1" "5" "1" "1022" "115.1" "7.96" "8.62" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00415, Pf00632, Pf13540" "55008" "ENSG00000138642" "HERC6" "B4DIY5; hsa:55008; Q5GC90; Q5GRH3; Q5HYM6; Q5JPB6; Q6PIF4; Q8IVU3; Q8NAN3; Q9NWS4" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.318" "0.986" "1.342" "0.979" "1.288" "0.955" "1.203" "1.025" "1.365" "193.2" "254.7" "190.5" "259.3" "189.2" "249.0" "184.6" "232.4" "198.0" "263.8" "" "" "" "" "" "" "" "" "" "" "115.6" "132.4" "105.5" "121.7" "87.7" "127.5" "85.8" "104.4" "107.4" "263.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3954168667574221268" "False" "Medium" "IsMasterProtein" "Q9H1J1" "Regulator of nonsense transcripts 3A OS=Homo sapiens OX=9606 GN=UPF3A PE=1 SV=1" "0.015" "False" "1.847" "1" "1" "1" "1" "476" "54.7" "9.03" "0.00" "1" "transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf03467" "65110" "ENSG00000169062" "UPF3A" "A2A366; hsa:65110; Q5T8C3; Q5T8C9; Q7Z6N3; Q86YK1; Q9BZI8; Q9H1J1" "" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6445951316860718443" "False" "Medium" "IsMasterProtein" "O60343" "TBC1 domain family member 4 OS=Homo sapiens OX=9606 GN=TBC1D4 PE=1 SV=2" "0.016" "False" "1.843" "1" "1" "1" "1" "1298" "146.5" "7.01" "0.00" "1" "transport;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00566, Pf00640, Pf11830" "9882" "ENSG00000136111" "TBC1D4" "A7E2X8; B4DU25; B4E235; B6ETN8; B6ETN9; hsa:9882; O60343; Q5W0B9; Q68D14" "Ciliary landscape; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8256721828910616389" "False" "Medium" "IsMasterProtein" "P55196" "Afadin OS=Homo sapiens OX=9606 GN=AFDN PE=1 SV=3" "0.016" "False" "1.842" "0" "1" "1" "1" "1824" "206.7" "6.47" "1.97" "1" "cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00498, Pf00595, Pf00788, Pf01843" "4301" "ENSG00000130396" "AFDN" "O75087; O75088; O75089; P55196; Q59FP0; Q5TIG6; Q5TIG7; Q9NSN7; Q9NU92" "VEGFA-VEGFR2 signaling; Ras signaling; 1q21.1 copy number variation syndrome" "" "3" "0" "1.416" "1.665" "1.373" "1.684" "1.396" "1.496" "0.761" "1.648" "1.658" "17.6" "24.9" "29.3" "24.1" "29.6" "24.5" "26.3" "13.4" "29.0" "29.1" "" "" "" "" "" "" "" "" "" "" "10.5" "12.9" "16.2" "11.3" "13.7" "12.6" "12.2" "6.0" "15.7" "29.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2262786275028472849" "False" "Medium" "IsMasterProtein" "Q9Y421" "Protein FAM32A OS=Homo sapiens OX=9606 GN=FAM32A PE=1 SV=2" "0.016" "False" "1.841" "8" "1" "1" "1" "112" "13.2" "9.99" "0.00" "1" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf08555" "26017" "ENSG00000105058" "FAM32A" "hsa:26017; Q9BT02; Q9Y421" "" "mRNA Splicing - Major Pathway" "1" "0" "1.165" "1.035" "1.070" "1.223" "0.850" "0.952" "1.216" "0.978" "0.464" "35.7" "41.6" "36.9" "38.2" "43.7" "30.4" "34.0" "43.4" "34.9" "16.6" "" "" "" "" "" "" "" "" "" "" "21.4" "21.6" "20.5" "17.9" "20.2" "15.5" "15.8" "19.5" "18.9" "16.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1583521273813264514" "False" "Medium" "IsMasterProtein" "P35236" "Tyrosine-protein phosphatase non-receptor type 7 OS=Homo sapiens OX=9606 GN=PTPN7 PE=1 SV=3" "0.016" "False" "1.840" "3" "1" "1" "1" "360" "40.5" "6.79" "2.23" "1" "protein metabolism;other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00102" "5778" "ENSG00000143851" "PTPN7" "B3KXE1; hsa:5778; P35236; Q53XK4; Q5SXQ0; Q5SXQ1; Q9BV05" "MAPK signaling pathway; IL-18 signaling pathway" "Negative regulation of MAPK pathway; Interleukin-37 signaling" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4003826422992493976" "False" "Medium" "IsMasterProtein" "Q9Y3D0" "Cytosolic iron-sulfur assembly component 2B OS=Homo sapiens OX=9606 GN=CIAO2B PE=1 SV=1" "0.016" "False" "1.837" "4" "1" "1" "1" "163" "17.7" "5.19" "2.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf01883" "51647" "ENSG00000166595" "CIAO2B" "hsa:51647; Q9Y3D0" "Iron-sulfur cluster biogenesis; 2q11.2 copy number variation syndrome" "Cytosolic iron-sulfur cluster assembly" "3" "0" "0.794" "1.080" "1.159" "1.424" "0.856" "1.004" "1.069" "1.057" "1.524" "53.5" "42.5" "57.8" "62.0" "76.2" "45.8" "53.7" "57.2" "56.5" "81.5" "" "" "" "" "" "" "" "" "" "" "32.0" "22.1" "32.0" "29.1" "35.3" "23.4" "25.0" "25.7" "30.7" "81.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2743146227967072639" "False" "Medium" "IsMasterProtein" "Q86WP2" "Vasculin OS=Homo sapiens OX=9606 GN=GPBP1 PE=1 SV=1" "0.016" "False" "1.834" "3" "1" "1" "1" "473" "53.3" "7.05" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15337" "65056" "ENSG00000062194" "GPBP1" "A6NKW3; hsa:65056; Q6NSH6; Q86WP2; Q9H0D4; Q9H785; Q9NSN4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "Not Found" "High" "High" "Not Found" "High" "Not Found" "High" "High" "1" "" "4950317330528062097" "False" "Medium" "IsMasterProtein" "Q92466" "DNA damage-binding protein 2 OS=Homo sapiens OX=9606 GN=DDB2 PE=1 SV=1" "0.016" "False" "1.830" "2" "1" "1" "1" "427" "47.8" "9.47" "2.13" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "1643" "ENSG00000134574" "DDB2" "B2R875; hsa:1643; Q76E54; Q76E55; Q76E56; Q76E57; Q92466" "miRNA regulation of DNA damage response; miRNA regulation of p53 pathway in prostate cancer; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Small cell lung cancer; Hepatitis B infection; Melanoma; Nucleotide excision repair; DNA repair pathways, full network; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum ; DNA damage response" "Neddylation; Ub-specific processing proteases; TP53 Regulates Transcription of DNA Repair Genes; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; Dual Incision in GG-NER" "21" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6273876737902892662" "False" "Medium" "IsMasterProtein" "P83876" "Thioredoxin-like protein 4A OS=Homo sapiens OX=9606 GN=TXNL4A PE=1 SV=1" "0.016" "False" "1.829" "5" "1" "3" "1" "142" "16.8" "5.85" "8.52" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf02966" "10907" "ENSG00000141759" "TXNL4A" "B2RC18; hsa:10907; O14834; P83876" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "1.099" "1.153" "1.131" "1.118" "1.111" "1.091" "1.217" "1.121" "0.889" "753.5" "827.8" "869.0" "852.1" "842.3" "837.0" "821.8" "917.0" "844.9" "669.5" "" "" "" "" "" "" "" "" "" "" "450.9" "430.2" "481.2" "400.0" "390.4" "428.5" "382.1" "411.7" "458.4" "669.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7667124068451477843" "False" "Medium" "IsMasterProtein" "P04035" "3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Homo sapiens OX=9606 GN=HMGCR PE=1 SV=1" "0.016" "False" "1.828" "1" "1" "1" "1" "888" "97.4" "6.74" "0.00" "1" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00368, Pf12349" "3156" "ENSG00000113161" "HMGCR" "B7Z3Y9; hsa:3156; P04035; Q8N190" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Mevalonate pathway; Statin inhibition of cholesterol production; Ferroptosis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "EGR2 and SOX10-mediated initiation of Schwann cell myelination" "14" "0" "1.378" "0.982" "0.924" "1.155" "1.161" "1.112" "1.105" "1.406" "0.958" "38.3" "52.8" "37.6" "35.4" "44.2" "44.5" "42.6" "42.3" "53.9" "36.7" "" "" "" "" "" "" "" "" "" "" "22.9" "27.4" "20.8" "16.6" "20.5" "22.8" "19.8" "19.0" "29.2" "36.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8080322362920288108" "False" "Medium" "IsMasterProtein" "Q7Z7F0" "KH homology domain-containing protein 4 OS=Homo sapiens OX=9606 GN=KHDC4 PE=1 SV=1" "0.016" "False" "1.827" "1" "1" "1" "1" "614" "64.8" "8.73" "2.41" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "" "22889" "ENSG00000132680" "KHDC4" "hsa:22889; O94981; Q7L7Q2; Q7Z7E9; Q7Z7F0; Q8TBQ0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4827998788629081219" "False" "Medium" "IsMasterProtein" "Q12834" "Cell division cycle protein 20 homolog OS=Homo sapiens OX=9606 GN=CDC20 PE=1 SV=2" "0.016" "False" "1.827" "2" "1" "1" "1" "499" "54.7" "9.23" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf12894" "991" "ENSG00000117399" "CDC20" "B2R6Z6; D3DPJ1; hsa:991; Q12834; Q5JUY4; Q9BW56; Q9UQI9" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; HDAC6 interactions in the central nervous system" "Antigen processing: Ubiquitination & Proteasome degradation; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Ub-specific processing proteases; Resolution of Sister Chromatid Cohesion; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of Emi1; APC-Cdc20 mediated degradation of Nek2A; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase" "23" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8981469479003528624" "False" "Medium" "IsMasterProtein" "Q9BZE1" "Large ribosomal subunit protein mL37 OS=Homo sapiens OX=9606 GN=MRPL37 PE=1 SV=2" "0.016" "False" "1.827" "2" "1" "1" "1" "423" "48.1" "8.59" "2.42" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf07147" "51253" "ENSG00000116221" "MRPL37" "hsa:51253; Q96Q67; Q9BWR1; Q9BZE1; Q9P0P3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.925" "1.079" "1.075" "1.083" "1.020" "0.880" "0.898" "0.948" "1.726" "79.3" "73.4" "85.6" "85.3" "85.9" "80.9" "69.8" "71.2" "75.2" "136.9" "" "" "" "" "" "" "" "" "" "" "47.5" "38.1" "47.4" "40.0" "39.8" "41.4" "32.5" "32.0" "40.8" "136.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4152940501784174244" "False" "Medium" "IsMasterProtein" "Q8TF61" "F-box only protein 41 OS=Homo sapiens OX=9606 GN=FBXO41 PE=1 SV=5" "0.016" "False" "1.825" "1" "1" "2" "1" "875" "94.4" "8.24" "3.81" "1" "" "cytosol" "" "Pf12937" "150726" "ENSG00000163013" "FBXO41" "G3V0Z7; hsa:150726; Q2M1V8; Q8TF61" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "0.785" "0.757" "0.643" "0.800" "0.698" "0.773" "0.776" "0.625" "0.125" "325.0" "255.2" "245.9" "209.1" "259.9" "226.7" "251.1" "252.2" "203.3" "40.8" "" "" "" "" "" "" "" "" "" "" "194.5" "132.6" "136.2" "98.1" "120.5" "116.1" "116.8" "113.2" "110.3" "40.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4231086194268643311" "False" "Medium" "IsMasterProtein" "Q8N6R0" "eEF1A lysine and N-terminal methyltransferase OS=Homo sapiens OX=9606 GN=METTL13 PE=1 SV=1" "0.016" "False" "1.823" "1" "1" "1" "1" "699" "78.7" "6.73" "1.91" "1" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01564, Pf13847" "51603" "ENSG00000010165" "METTL13" "A6NFK0; A8K6S5; hsa:51603; O94940; Q53EZ6; Q5TGP9; Q5TGQ0; Q8N2P8; Q8N6R0; Q96J11; Q96SQ0; Q9Y2Z1; Q9Y3M6" "" "" "0" "0" "0.973" "1.059" "0.978" "0.967" "1.266" "1.037" "0.517" "0.790" "3.450" "41.9" "40.8" "44.4" "41.0" "40.5" "53.1" "43.5" "21.7" "33.1" "144.7" "" "" "" "" "" "" "" "" "" "" "25.1" "21.2" "24.6" "19.2" "18.8" "27.2" "20.2" "9.7" "18.0" "144.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2093622572460603588" "False" "Medium" "IsMasterProtein" "Q8NBF6" "Late secretory pathway protein AVL9 homolog OS=Homo sapiens OX=9606 GN=AVL9 PE=1 SV=1" "0.016" "False" "1.822" "2" "1" "1" "1" "648" "71.9" "6.21" "0.00" "1" "other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf09794" "23080" "ENSG00000105778" "AVL9" "hsa:23080; Q8NBF6; Q92573" "" "" "0" "0" "1.216" "1.356" "1.319" "1.176" "1.572" "1.431" "1.426" "1.177" "1.290" "32.1" "39.1" "43.6" "42.4" "37.8" "50.5" "46.0" "45.8" "37.8" "41.5" "" "" "" "" "" "" "" "" "" "" "19.2" "20.3" "24.1" "19.9" "17.5" "25.9" "21.4" "20.6" "20.5" "41.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5229408047793123568" "False" "Medium" "IsMasterProtein" "O75155" "Cullin-associated NEDD8-dissociated protein 2 OS=Homo sapiens OX=9606 GN=CAND2 PE=1 SV=3" "0.016" "False" "1.817" "1" "1" "1" "1" "1236" "135.2" "5.68" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf08623" "23066" "ENSG00000144712" "CAND2" "B9EGM9; E9KL24; hsa:23066; O75155" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "436282700212558245" "False" "Medium" "IsMasterProtein" "P17676" "CCAAT/enhancer-binding protein beta OS=Homo sapiens OX=9606 GN=CEBPB PE=1 SV=2" "0.016" "False" "1.814" "3" "1" "1" "1" "345" "36.1" "8.31" "0.00" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07716" "1051" "ENSG00000172216" "CEBPB" "A8K671; hsa:1051; P17676; Q96IH2; Q9H4Z5" "Folate-alcohol and cancer pathway hypotheses; IL-17 signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Differentiation of white and brown adipocyte; Transcriptional activation by NRF2 in response to phytochemicals; Ovarian infertility; Transcription factor regulation in adipogenesis; Lung fibrosis; IL-4 signaling pathway; Exercise-induced circadian regulation; White fat cell differentiation; Transcriptional cascade regulating adipogenesis; NRF2-ARE regulation; IL-18 signaling pathway; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; GDNF signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "Transcriptional regulation of white adipocyte differentiation; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Transcriptional regulation of granulopoiesis; Response of EIF2AK1 (HRI) to heme deficiency; ATF4 activates genes in response to endoplasmic reticulum stress; Response of EIF2AK4 (GCN2) to amino acid deficiency; Nuclear events stimulated by ALK signaling in cancer" "28" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6059650845564073715" "False" "Medium" "IsMasterProtein" "Q5SRH9" "Tetratricopeptide repeat protein 39A OS=Homo sapiens OX=9606 GN=TTC39A PE=1 SV=1" "0.016" "False" "1.814" "1" "1" "4" "1" "613" "69.7" "7.47" "7.28" "1" "" "cytoskeleton" "" "Pf10300" "22996" "ENSG00000085831" "TTC39A" "B7Z782; E7EQY9; G3XAF8; hsa:22996; O43417; O75040; Q5SRH5; Q5SRH6; Q5SRH7; Q5SRH8; Q5SRH9; Q5SRI0; Q5SRI1; Q5SRI2; Q5T7S1; Q6PIU8; Q9BT24" "" "" "0" "0" "0.984" "0.954" "0.973" "0.891" "1.031" "0.927" "1.000" "0.962" "0.712" "175.8" "172.9" "167.8" "171.0" "156.6" "181.2" "163.0" "175.7" "169.1" "125.2" "" "" "" "" "" "" "" "" "" "" "105.2" "89.9" "92.9" "80.3" "72.6" "92.8" "75.8" "78.9" "91.8" "125.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3757021002134428310" "False" "Medium" "IsMasterProtein" "Q8TBM8" "DnaJ homolog subfamily B member 14 OS=Homo sapiens OX=9606 GN=DNAJB14 PE=1 SV=1" "0.016" "False" "1.811" "2" "1" "1" "1" "379" "42.5" "8.59" "1.65" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf00226, Pf09320" "79982" "ENSG00000164031" "DNAJB14" "hsa:79982; Q6UXN1; Q7Z3P0; Q86TA7; Q86TM0; Q8TBM8; Q9GZU9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7489520263377738348" "False" "Medium" "IsMasterProtein" "Q96DI7" "U5 small nuclear ribonucleoprotein 40 kDa protein OS=Homo sapiens OX=9606 GN=SNRNP40 PE=1 SV=1" "0.016" "False" "1.811" "3" "1" "3" "1" "357" "39.3" "8.10" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00400" "9410" "ENSG00000060688" "SNRNP40" "B4DQJ1; hsa:9410; O75938; O95320; Q96DI7" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6910081975799465505" "False" "Medium" "IsMasterProtein" "O15042" "U2 snRNP-associated SURP motif-containing protein OS=Homo sapiens OX=9606 GN=U2SURP PE=1 SV=2" "0.016" "False" "1.811" "3" "1" "1" "1" "1029" "118.2" "8.47" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00076, Pf01805, Pf04818, Pf08312" "23350" "ENSG00000163714" "U2SURP" "A0PJ60; hsa:23350; O15042; Q0D2M1; Q2NKQ7; Q9BR70" "" "mRNA Splicing - Major Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "High" "1" "" "-3796638279955905475" "False" "Medium" "IsMasterProtein" "Q9NZ32" "Actin-related protein 10 OS=Homo sapiens OX=9606 GN=ACTR10 PE=1 SV=1" "0.016" "False" "1.810" "2" "1" "1" "1" "417" "46.3" "7.37" "1.89" "1" "transport" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "" "Pf00022" "55860" "ENSG00000131966" "ACTR10" "hsa:55860; Q9H9Y5; Q9NWY2; Q9NZ32" "" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation" "5" "0" "0.951" "0.930" "0.921" "1.042" "0.953" "0.949" "0.998" "0.852" "0.610" "33.2" "31.6" "30.9" "30.6" "34.6" "31.6" "31.5" "33.1" "28.3" "20.3" "" "" "" "" "" "" "" "" "" "" "19.9" "16.4" "17.1" "14.4" "16.0" "16.2" "14.7" "14.9" "15.3" "20.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-776165374606149247" "False" "Medium" "IsMasterProtein" "Q99547" "M-phase phosphoprotein 6 OS=Homo sapiens OX=9606 GN=MPHOSPH6 PE=1 SV=2" "0.017" "False" "1.804" "4" "1" "1" "1" "160" "19.0" "5.20" "2.75" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf10175" "10200" "ENSG00000135698" "MPHOSPH6" "B2RAF0; hsa:10200; Q99547" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6661052113090988194" "False" "Medium" "IsMasterProtein" "O95153" "Peripheral-type benzodiazepine receptor-associated protein 1 OS=Homo sapiens OX=9606 GN=TSPOAP1 PE=1 SV=2" "0.017" "False" "1.801" "1" "1" "2" "1" "1857" "199.9" "5.11" "0.00" "1" "transport" "cytosol;mitochondrion;other cell component" "signal transduction activity or receptor binding;transporter activity" "Pf07653, Pf14604" "9256" "ENSG00000005379" "TSPOAP1" "hsa:9256; O75111; O95153; Q8N5W3" "" "Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Pregnenolone biosynthesis" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-263352969811880337" "False" "Medium" "IsMasterProtein" "Q13432" "Protein unc-119 homolog A OS=Homo sapiens OX=9606 GN=UNC119 PE=1 SV=1" "0.017" "False" "1.798" "4" "1" "1" "1" "240" "26.9" "6.42" "1.63" "1" "cell-cell signaling;cell cycle OR cell proliferation;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf05351" "9094" "ENSG00000109103" "UNC119" "A8K8G4; F1T095; hsa:9094; O95126; Q13432" "Joubert syndrome; Ciliopathies" "" "2" "0" "1.048" "1.094" "1.320" "1.721" "1.205" "2.657" "0.538" "1.385" "3.955" "16.9" "17.7" "18.5" "22.3" "29.0" "20.3" "44.8" "9.1" "23.4" "66.7" "" "" "" "" "" "" "" "" "" "" "10.1" "9.2" "10.2" "10.5" "13.5" "10.4" "20.8" "4.1" "12.7" "66.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2600718552513118007" "False" "Medium" "IsMasterProtein" "Q86VR2" "Reticulophagy regulator 3 OS=Homo sapiens OX=9606 GN=RETREG3 PE=1 SV=1" "0.017" "False" "1.787" "2" "1" "1" "1" "466" "51.4" "4.97" "1.80" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "" "162427" "ENSG00000141699" "RETREG3" "B3KR75; hsa:162427; Q86VR2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8485123881553311665" "False" "Medium" "IsMasterProtein" "Q8TEB1" "DDB1- and CUL4-associated factor 11 OS=Homo sapiens OX=9606 GN=DCAF11 PE=1 SV=1" "0.017" "False" "1.787" "2" "1" "1" "1" "546" "61.6" "6.40" "0.00" "1" "protein metabolism;other metabolic processes" "nucleus;other cell component" "" "Pf00400" "80344" "ENSG00000100897; ENSG00000284796" "DCAF11" "B3KQ83; D3DS56; hsa:80344; Q5D039; Q86U00; Q86U39; Q8NDN2; Q8TEB1; Q9H2J0; Q9H3A3; Q9H5C9" "Ciliary landscape" "Neddylation" "2" "0" "0.831" "1.041" "0.974" "1.262" "1.154" "1.009" "1.063" "1.048" "0.812" "30.2" "25.1" "31.4" "29.4" "38.1" "34.8" "30.5" "32.1" "31.7" "24.5" "" "" "" "" "" "" "" "" "" "" "18.1" "13.0" "17.4" "13.8" "17.7" "17.8" "14.2" "14.4" "17.2" "24.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-421733537835387635" "False" "Medium" "IsMasterProtein" "Q9NPE2" "Neugrin OS=Homo sapiens OX=9606 GN=NGRN PE=1 SV=2" "0.017" "False" "1.786" "3" "1" "1" "1" "291" "32.4" "9.10" "1.95" "1" "cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf06413" "51335" "ENSG00000182768" "NGRN" "B2R6M8; hsa:51335; Q4V9L7; Q9HBL4; Q9NPE2" "" "" "0" "0" "1.367" "1.208" "1.102" "1.508" "1.231" "1.341" "1.004" "1.120" "0.786" "20.1" "27.4" "24.2" "22.1" "30.3" "24.7" "26.9" "20.1" "22.5" "15.8" "" "" "" "" "" "" "" "" "" "" "12.0" "14.3" "13.4" "10.4" "14.0" "12.6" "12.5" "9.0" "12.2" "15.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5006011140067138200" "False" "Medium" "IsMasterProtein" "Q9Y287" "Integral membrane protein 2B OS=Homo sapiens OX=9606 GN=ITM2B PE=1 SV=1" "0.017" "False" "1.786" "4" "1" "1" "1" "266" "30.3" "5.14" "2.14" "1" "developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04089" "9445" "ENSG00000136156" "ITM2B" "Q5W0A3; Q96B24; Q9NYH1; Q9Y287" "" "Amyloid fiber formation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8766767178054047588" "False" "Medium" "IsMasterProtein" "Q9BYC9" "Large ribosomal subunit protein bL20m OS=Homo sapiens OX=9606 GN=MRPL20 PE=1 SV=1" "0.017" "False" "1.785" "5" "1" "1" "1" "149" "17.4" "10.86" "2.08" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00453" "55052" "ENSG00000242485" "MRPL20" "B2RE41; B7Z746; hsa:55052; Q9BYC9" "1p36 copy number variation syndrome" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5494004990375454112" "False" "Medium" "IsMasterProtein" "Q9ULH0" "Kinase D-interacting substrate of 220 kDa OS=Homo sapiens OX=9606 GN=KIDINS220 PE=1 SV=3" "0.017" "False" "1.783" "1" "1" "1" "1" "1771" "196.4" "6.62" "1.63" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf07693, Pf12796" "57498" "ENSG00000134313" "KIDINS220" "A1L4N4; Q4VC08; Q6MZU2; Q9H889; Q9H9E4; Q9NT37; Q9UF42; Q9ULH0" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Neural crest cell migration in cancer" "RND2 GTPase cycle; RND1 GTPase cycle; ARMS-mediated activation" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-345522786131708725" "False" "Medium" "IsMasterProtein" "Q14571" "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 OS=Homo sapiens OX=9606 GN=ITPR2 PE=1 SV=2" "0.017" "False" "1.780" "0" "1" "4" "1" "2701" "307.9" "6.43" "9.32" "1" "stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00520, Pf01365, Pf02815, Pf08454, Pf08709" "3709" "ENSG00000123104" "ITPR2" "hsa:3709; O94773; Q14571" "Alzheimer's disease and miRNA effects; Myometrial relaxation and contraction pathways; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Alzheimer's disease; GDNF signaling; Calcium regulation in cardiac cells" "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Ion homeostasis; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Ca2+ pathway; VEGFR2 mediated cell proliferation; Elevation of cytosolic Ca2+ levels; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation; Effects of PIP2 hydrolysis" "21" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1384123657554198198" "False" "Medium" "IsMasterProtein" "Q8NHQ9" "ATP-dependent RNA helicase DDX55 OS=Homo sapiens OX=9606 GN=DDX55 PE=1 SV=3" "0.017" "False" "1.780" "2" "1" "1" "1" "600" "68.5" "9.25" "0.00" "1" "" "cytosol;nucleus" "other molecular function" "Pf00270, Pf00271, Pf13959" "57696" "ENSG00000111364" "DDX55" "hsa:57696; Q658L6; Q8IYH0; Q8NHQ9; Q9HCH7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6875111383431957192" "False" "Medium" "IsMasterProtein" "Q8IYW5" "E3 ubiquitin-protein ligase RNF168 OS=Homo sapiens OX=9606 GN=RNF168 PE=1 SV=1" "0.017" "False" "1.774" "1" "1" "1" "1" "571" "65.0" "7.96" "1.72" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097" "165918" "ENSG00000163961" "RNF168" "hsa:165918; Q8IYW5; Q8NA67; Q96NS4" "ATM signaling in development and disease ; 3q29 copy number variation syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome" "Processing of DNA double-strand break ends; SUMOylation of DNA damage response and repair proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5573566891233996467" "False" "Medium" "IsMasterProtein" "Q96FV2" "Secernin-2 OS=Homo sapiens OX=9606 GN=SCRN2 PE=1 SV=3" "0.017" "False" "1.773" "3" "1" "1" "1" "425" "46.6" "5.67" "0.00" "1" "protein metabolism" "" "other molecular function" "Pf03577" "90507" "ENSG00000141295" "SCRN2" "A8K3N1; B7Z8S7; E9PBV5; hsa:90507; Q96AC3; Q96FV2; Q9BU04" "" "" "0" "0" "1.482" "1.711" "1.544" "1.296" "1.171" "1.309" "1.579" "1.494" "1.998" "20.7" "30.7" "35.4" "32.0" "26.8" "24.2" "27.1" "32.7" "30.9" "41.4" "" "" "" "" "" "" "" "" "" "" "12.4" "15.9" "19.6" "15.0" "12.4" "12.4" "12.6" "14.7" "16.8" "41.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "29627463948576905" "False" "Medium" "IsMasterProtein" "Q9NUQ8" "ATP-binding cassette sub-family F member 3 OS=Homo sapiens OX=9606 GN=ABCF3 PE=1 SV=2" "0.017" "False" "1.773" "1" "1" "2" "1" "709" "79.7" "6.34" "1.78" "1" "stress response" "" "other molecular function" "Pf00005, Pf12848" "55324" "ENSG00000161204" "ABCF3" "A8K241; hsa:55324; Q86UA2; Q8NAN1; Q96GS8; Q9H7A8; Q9NUQ8" "" "" "0" "0" "1.199" "0.976" "0.729" "1.260" "1.727" "1.265" "0.553" "1.085" "3.893" "15.5" "18.6" "15.2" "11.3" "19.6" "26.8" "19.7" "8.6" "16.9" "60.5" "" "" "" "" "" "" "" "" "" "" "9.3" "9.7" "8.4" "5.3" "9.1" "13.7" "9.1" "3.9" "9.1" "60.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7469427958651967746" "False" "Medium" "IsMasterProtein" "Q9GZL7" "Ribosome biogenesis protein WDR12 OS=Homo sapiens OX=9606 GN=WDR12 PE=1 SV=2" "0.017" "False" "1.773" "2" "1" "1" "1" "423" "47.7" "5.90" "2.60" "1" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf08154" "55759" "ENSG00000138442" "WDR12" "B3KPA9; hsa:55759; Q96HU0; Q9GZL7; Q9NV80; Q9NYI8" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6084938480373239837" "False" "Medium" "IsMasterProtein" "O15525" "Transcription factor MafG OS=Homo sapiens OX=9606 GN=MAFG PE=1 SV=1" "0.018" "False" "1.766" "6" "1" "1" "1" "162" "17.8" "10.04" "1.68" "1" "developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03131" "4097" "ENSG00000197063" "MAFG" "hsa:4097; O15525" "Quercetin and Nf-kB / AP-1 induced apoptosis; Nuclear receptors meta-pathway; NRF2 pathway; Ethanol metabolism production of ROS by CYP2E1; Rubinstein-Taybi syndrome 1" "Factors involved in megakaryocyte development and platelet production; Nuclear events mediated by NFE2L2; NFE2L2 regulates pentose phosphate pathway genes" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1054198857384115692" "False" "Medium" "IsMasterProtein" "O14492" "SH2B adapter protein 2 OS=Homo sapiens OX=9606 GN=SH2B2 PE=1 SV=2" "0.018" "False" "1.762" "2" "1" "1" "1" "632" "67.7" "6.27" "0.00" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00169, Pf08916" "10603" "ENSG00000160999" "SH2B2" "A0A0A0MTI2; A6ND74; O14492" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; Insulin signaling" "Regulation of KIT signaling; Factors involved in megakaryocyte development and platelet production" "5" "0" "1.152" "1.302" "1.184" "1.734" "0.846" "0.930" "1.036" "0.881" "4.365" "16.7" "19.2" "21.7" "19.8" "28.9" "14.1" "15.5" "17.3" "14.7" "72.9" "" "" "" "" "" "" "" "" "" "" "10.0" "10.0" "12.0" "9.3" "13.4" "7.2" "7.2" "7.8" "8.0" "72.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5390707735378390925" "False" "Medium" "IsMasterProtein" "Q8IYB3" "Serine/arginine repetitive matrix protein 1 OS=Homo sapiens OX=9606 GN=SRRM1 PE=1 SV=2" "0.018" "False" "1.761" "1" "1" "1" "1" "904" "102.3" "11.84" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf01480" "10250" "ENSG00000133226" "SRRM1" "hsa:10250; O60585; Q5VVN4; Q8IYB3" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "7" "0" "0.996" "0.784" "1.178" "0.952" "1.115" "0.768" "0.906" "0.999" "0.431" "25.7" "25.6" "20.1" "30.3" "24.5" "28.7" "19.8" "23.3" "25.7" "11.1" "" "" "" "" "" "" "" "" "" "" "15.4" "13.3" "11.2" "14.2" "11.3" "14.7" "9.2" "10.5" "13.9" "11.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8013804065466167884" "False" "Medium" "IsMasterProtein" "Q3B7T1" "Erythroid differentiation-related factor 1 OS=Homo sapiens OX=9606 GN=EDRF1 PE=1 SV=1" "0.018" "False" "1.758" "1" "1" "1" "1" "1238" "138.4" "6.33" "0.00" "1" "other biological processes" "nucleus" "" "" "26098" "ENSG00000107938" "EDRF1" "B2RC65; hsa:26098; Q3B7T1; Q3KR40; Q4G190; Q5VZQ4; Q8IZ74; Q9Y3W4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3859888159614048527" "False" "Medium" "IsMasterProtein" "Q9NRP4" "Succinate dehydrogenase assembly factor 3, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF3 PE=1 SV=1" "0.018" "False" "1.755" "7" "1" "1" "1" "125" "14.6" "9.07" "0.00" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "mitochondrion" "" "Pf13233" "57001" "ENSG00000196636" "SDHAF3" "A4D1J3; hsa:57001; Q75MD6; Q9NRP4" "Mitochondrial complex II assembly" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4669719094448447392" "False" "Medium" "IsMasterProtein" "Q9BSJ8" "Extended synaptotagmin-1 OS=Homo sapiens OX=9606 GN=ESYT1 PE=1 SV=1" "0.018" "False" "1.754" "1" "1" "1" "1" "1104" "122.8" "5.83" "2.20" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;ER/Golgi" "transporter activity;other molecular function" "Pf00168, Pf17047" "23344" "ENSG00000139641" "ESYT1" "A0FGR7; A8K2S2; hsa:23344; O94848; Q6PJN4; Q9BSJ8; Q9H6J1; Q9H6W2; Q9Y416" "" "RHOG GTPase cycle; Glycosphingolipid transport; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4999747194437679436" "False" "Medium" "IsMasterProtein" "Q969M7" "NEDD8-conjugating enzyme UBE2F OS=Homo sapiens OX=9606 GN=UBE2F PE=1 SV=1" "0.018" "False" "1.750" "5" "1" "1" "1" "185" "21.1" "6.79" "1.62" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179" "140739" "ENSG00000184182" "UBE2F" "A8K1Z8; B4DDT9; B4DFI1; B4DMK3; B4DZU2; B8ZZG2; C9J212; H9KVB9; Q969M7" "2q37 copy number variation syndrome" "Neddylation; Antigen processing: Ubiquitination & Proteasome degradation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7153575726197497326" "False" "Medium" "IsMasterProtein" "Q7Z6B0" "Coiled-coil domain-containing protein 91 OS=Homo sapiens OX=9606 GN=CCDC91 PE=1 SV=2" "0.018" "False" "1.748" "2" "1" "1" "1" "441" "49.9" "5.07" "0.00" "1" "transport" "other membranes;cytosol;ER/Golgi;nucleus" "" "" "55297" "ENSG00000123106" "CCDC91" "B3KSA3; C9JR07; hsa:55297; Q68D43; Q6IA78; Q7Z6B0; Q8NEN7; Q9NUW9" "" "" "0" "0" "1.229" "1.159" "1.053" "1.185" "1.044" "0.946" "1.013" "1.225" "1.254" "24.1" "29.7" "28.0" "25.4" "28.6" "25.2" "22.8" "24.5" "29.6" "30.3" "" "" "" "" "" "" "" "" "" "" "14.5" "15.4" "15.5" "11.9" "13.3" "12.9" "10.6" "11.0" "16.0" "30.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9198167910452048535" "False" "Medium" "IsMasterProtein" "P18887" "DNA repair protein XRCC1 OS=Homo sapiens OX=9606 GN=XRCC1 PE=1 SV=3" "0.018" "False" "1.748" "2" "1" "1" "1" "633" "69.5" "6.28" "2.19" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf01834" "7515" "ENSG00000073050" "XRCC1" "hsa:7515; P18887; Q6IBS4; Q9HCB1" "Base excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Gap-filling DNA repair synthesis and ligation in TC-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; HDR through MMEJ (alt-NHEJ); Resolution of AP sites via the single-nucleotide replacement pathway; Gap-filling DNA repair synthesis and ligation in GG-NER" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7453155325725910333" "False" "Medium" "IsMasterProtein" "Q9Y2K2" "Serine/threonine-protein kinase SIK3 OS=Homo sapiens OX=9606 GN=SIK3 PE=1 SV=4" "0.018" "False" "1.744" "2" "1" "1" "1" "1321" "144.8" "6.79" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069" "23387" "ENSG00000160584" "SIK3" "A1A5A8; H0Y494; hsa:23387; J3KPC8; Q59FY2; Q5M9N1; Q6P3R6; Q8IYM8; Q9HA50; Q9Y2K2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "High" "1" "" "-7073332157955076013" "False" "Medium" "IsMasterProtein" "P50914" "Large ribosomal subunit protein eL14 OS=Homo sapiens OX=9606 GN=RPL14 PE=1 SV=4" "0.019" "False" "1.742" "6" "1" "1" "1" "215" "23.4" "10.93" "0.00" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01929" "9045" "ENSG00000188846" "RPL14" "hsa:9045; P50914; Q45RF0; Q53G20; Q8TBD5; Q8WUT0; Q92579; Q96GR0; Q9BSB8; Q9BW65; Q9BYF6" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8392578490847645683" "False" "Medium" "IsMasterProtein" "Q9NR33" "DNA polymerase epsilon subunit 4 OS=Homo sapiens OX=9606 GN=POLE4 PE=1 SV=2" "0.019" "False" "1.741" "9" "1" "1" "1" "117" "12.2" "4.92" "0.00" "1" "DNA metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "56655" "ENSG00000115350" "POLE4" "Q53TR2; Q9NR33" "Pyrimidine metabolism; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "PCNA-Dependent Long Patch Base Excision Repair; Activation of the pre-replicative complex; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; DNA replication initiation; Gap-filling DNA repair synthesis and ligation in GG-NER" "16" "0" "0.494" "0.793" "1.132" "1.154" "1.228" "1.013" "0.801" "1.413" "1.829" "17.5" "8.6" "13.9" "19.8" "20.2" "21.5" "17.7" "14.0" "24.7" "32.0" "" "" "" "" "" "" "" "" "" "" "10.5" "4.5" "7.7" "9.3" "9.3" "11.0" "8.2" "6.3" "13.4" "32.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2774466273942528480" "False" "Medium" "IsMasterProtein" "O43379" "WD repeat-containing protein 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=4" "0.019" "False" "1.737" "1" "1" "1" "1" "1518" "165.8" "5.91" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus" "" "Pf00400" "284403" "ENSG00000075702" "WDR62" "hsa:284403; O43379; Q63HP9; Q659D7; Q8NBF7; Q96AD9" "Primary ovarian insufficiency" "" "1" "0" "1.118" "0.803" "0.407" "0.892" "0.921" "0.751" "0.782" "0.985" "2.622" "17.8" "19.9" "14.3" "7.3" "15.9" "16.4" "13.4" "13.9" "17.6" "46.7" "" "" "" "" "" "" "" "" "" "" "10.7" "10.3" "7.9" "3.4" "7.4" "8.4" "6.2" "6.3" "9.5" "46.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-694609227641095706" "False" "Medium" "IsMasterProtein" "Q5T8I3" "EEIG family member 2 OS=Homo sapiens OX=9606 GN=EEIG2 PE=1 SV=2" "0.019" "False" "1.737" "4" "1" "1" "1" "360" "39.3" "7.02" "0.00" "1" "" "" "" "Pf10358" "284611" "ENSG00000162636" "EEIG2" "A1L1A1; B0QZ46; B0QZ47; hsa:284611; Q5T8I3; Q68DH7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7971569862806086425" "False" "Medium" "IsMasterProtein" "Q9Y2Z4" "Tyrosine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=YARS2 PE=1 SV=2" "0.019" "False" "1.735" "2" "1" "1" "1" "477" "53.2" "8.98" "1.81" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00579" "51067" "ENSG00000139131" "YARS2" "D3DUW8; hsa:51067; Q9H817; Q9Y2Z4" "Orexin receptor pathway" "Mitochondrial tRNA aminoacylation" "2" "0" "0.584" "0.976" "0.820" "1.032" "0.849" "0.946" "0.600" "0.871" "2.298" "72.4" "42.3" "70.7" "59.4" "74.7" "61.5" "68.5" "43.5" "63.1" "166.4" "" "" "" "" "" "" "" "" "" "" "43.3" "22.0" "39.1" "27.9" "34.6" "31.5" "31.8" "19.5" "34.2" "166.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4534228375388649933" "False" "Medium" "IsMasterProtein" "P52948" "Nuclear pore complex protein Nup98-Nup96 OS=Homo sapiens OX=9606 GN=NUP98 PE=1 SV=4" "0.019" "False" "1.730" "1" "1" "1" "1" "1817" "197.5" "6.40" "0.00" "1" "cell organization and biogenesis;protein metabolism;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04096, Pf12110, Pf21240" "4928" "ENSG00000110713" "NUP98" "hsa:4928; P52948; Q8IUT2; Q8WYB0; Q96E54; Q9H3Q4; Q9NT02; Q9UF57; Q9UHX0; Q9Y6J4; Q9Y6J5" "SARS-CoV-2 innate immunity evasion and cell-specific immune response" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7340038753290804182" "False" "Medium" "IsMasterProtein" "Q9Y5B9" "FACT complex subunit SPT16 OS=Homo sapiens OX=9606 GN=SUPT16H PE=1 SV=1" "0.019" "False" "1.727" "1" "1" "1" "1" "1047" "119.8" "5.66" "1.68" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00557, Pf08512, Pf08644, Pf14826, Pf21091" "11198" "ENSG00000092201" "SUPT16H" "hsa:11198; Q6GMT8; Q6P2F1; Q6PJM1; Q9NRX0; Q9Y5B9" "" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8065453246646173554" "False" "Medium" "IsMasterProtein" "O15231" "Zinc finger protein 185 OS=Homo sapiens OX=9606 GN=ZNF185 PE=1 SV=3" "0.019" "False" "1.727" "1" "1" "1" "1" "689" "73.5" "7.01" "1.95" "1" "" "cytoskeleton;other cell component" "other molecular function" "" "7739" "ENSG00000147394; ENSG00000292196" "ZNF185" "A4FTV3; A6NME5; B4DLE9; B7Z771; B8K2L9; B8K2M0; B8K2M1; B8K2M2; E9PFR6; F5GXF7; F5GZL4; F8W8V7; H0Y4M8; hsa:7739; O00345; O15231; Q8N1R8; Q9NSD2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4014732936272449079" "False" "Medium" "IsMasterProtein" "Q53EL6" "Programmed cell death protein 4 OS=Homo sapiens OX=9606 GN=PDCD4 PE=1 SV=2" "0.019" "False" "1.727" "3" "1" "1" "1" "469" "51.7" "5.21" "1.70" "1" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02847" "27250" "ENSG00000150593" "PDCD4" "B2RCV4; B5ME91; hsa:27250; O15501; Q53EL6; Q5VZS6; Q6PJI5; Q8TAR5; Q99834" "Translation inhibitors in chronically activated PDGFRA cells; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-912573818931081677" "False" "Medium" "IsMasterProtein" "P48736" "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform OS=Homo sapiens OX=9606 GN=PIK3CG PE=1 SV=3" "0.019" "False" "1.726" "1" "1" "1" "1" "1102" "126.4" "7.50" "0.00" "1" "cell adhesion;cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792, Pf00794, Pf19710" "5294" "ENSG00000105851" "PIK3CG" "A4D0Q6; hsa:5294; P48736; Q8IV23; Q9BZC8" "IL-5 signaling pathway; AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Prolactin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; BDNF-TrkB signaling; Amplification and expansion of oncogenic pathways as metastatic traits; Physico-chemical features and toxicity-associated pathways; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; Microglia pathogen phagocytosis pathway; PI3K-Akt signaling pathway; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; Osteoblast differentiation and related diseases; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Prostaglandin signaling; Opioid receptor pathways; Regulation of actin cytoskeleton; EPO receptor signaling; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "Synthesis of PIPs at the plasma membrane; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); GPVI-mediated activation cascade; G beta:gamma signalling through PI3Kgamma; Signaling by CSF1 (M-CSF) in myeloid cells" "40" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6359108141380896600" "False" "Medium" "IsMasterProtein" "Q86W50" "RNA N6-adenosine-methyltransferase METTL16 OS=Homo sapiens OX=9606 GN=METTL16 PE=1 SV=2" "0.019" "False" "1.717" "2" "1" "1" "1" "562" "63.6" "7.85" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05971" "79066" "ENSG00000127804" "METTL16" "D3DTI8; hsa:79066; Q86TE5; Q86W50; Q96T16; Q9BVG7" "" "" "0" "0" "1.137" "1.021" "1.385" "1.306" "1.082" "0.514" "1.160" "0.511" "3.890" "12.9" "14.6" "13.1" "17.8" "16.8" "13.9" "6.6" "14.9" "6.6" "50.0" "" "" "" "" "" "" "" "" "" "" "7.7" "7.6" "7.3" "8.4" "7.8" "7.1" "3.1" "6.7" "3.6" "50.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4596787228496680093" "False" "Medium" "IsMasterProtein" "Q9BV86" "N-terminal Xaa-Pro-Lys N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=NTMT1 PE=1 SV=3" "0.019" "False" "1.714" "4" "1" "1" "1" "223" "25.4" "5.52" "2.46" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05891" "28989" "ENSG00000148335" "NTMT1" "A8K4J2; A8K8G7; hsa:28989; Q5SZB9; Q9BV86; Q9UI28" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "795128292940512142" "False" "Medium" "IsMasterProtein" "Q96IU2" "Zinc finger BED domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZBED3 PE=1 SV=1" "0.019" "False" "1.712" "3" "1" "1" "1" "234" "25.1" "8.31" "0.00" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf02892" "84327" "ENSG00000132846" "ZBED3" "hsa:84327; Q96IU2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5148486115263509013" "False" "Medium" "IsMasterProtein" "Q9C0B0" "RING finger protein unkempt homolog OS=Homo sapiens OX=9606 GN=UNK PE=1 SV=2" "0.019" "False" "1.710" "1" "1" "1" "1" "810" "88.0" "6.86" "2.75" "1" "developmental processes;other biological processes" "other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00642, Pf18384" "85451" "ENSG00000132478" "UNK" "hsa:85451; Q9C0B0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8965718931841673636" "False" "Medium" "IsMasterProtein" "Q9Y496" "Kinesin-like protein KIF3A OS=Homo sapiens OX=9606 GN=KIF3A PE=1 SV=4" "0.019" "False" "1.705" "2" "1" "1" "1" "699" "80.0" "6.54" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "11127" "ENSG00000131437" "KIF3A" "A8MSW9; hsa:11127; Q59EN1; Q86XE9; Q9Y496; Q9Y6V4" "Hedgehog signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Insulin signaling" "Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Kinesins; Hedgehog 'off' state; Activation of SMO" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "High" "Not Found" "Not Found" "Not Found" "Not Found" "High" "Not Found" "High" "1" "" "3609131082227720096" "False" "Medium" "IsMasterProtein" "O15499" "Homeobox protein goosecoid-2 OS=Homo sapiens OX=9606 GN=GSC2 PE=1 SV=1" "0.019" "False" "1.705" "5" "1" "2" "1" "205" "21.5" "10.55" "4.35" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046" "2928" "ENSG00000063515" "GSC2" "hsa:2928; O15499" "22q11.2 copy number variation syndrome" "" "1" "0" "0.972" "0.891" "0.963" "1.038" "0.960" "0.987" "1.053" "0.914" "0.744" "313.4" "304.7" "279.2" "301.9" "325.4" "301.0" "309.3" "329.9" "286.6" "233.3" "" "" "" "" "" "" "" "" "" "" "187.6" "158.3" "154.6" "141.7" "150.8" "154.1" "143.8" "148.1" "155.5" "233.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-411341991637906360" "False" "Medium" "IsMasterProtein" "P27448" "MAP/microtubule affinity-regulating kinase 3 OS=Homo sapiens OX=9606 GN=MARK3 PE=1 SV=5" "0.019" "False" "1.703" "1" "1" "1" "1" "753" "84.4" "9.57" "0.00" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00627, Pf02149" "4140" "ENSG00000075413" "MARK3" "A0A0A0MQR8; A0A0A0MST9; A0A0A0MT23; hsa:4140; O60219; P27448; Q86TT8; Q8TB41; Q8WX83; Q96RG1; Q9UMY9; Q9UN34" "Complement system in neuronal development and plasticity" "Signaling by BRAF and RAF1 fusions; RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "10" "0" "0.848" "0.657" "0.804" "0.745" "0.713" "1.075" "1.462" "0.657" "2.255" "16.6" "14.1" "10.9" "13.3" "12.3" "11.8" "17.8" "24.2" "10.9" "37.4" "" "" "" "" "" "" "" "" "" "" "9.9" "7.3" "6.0" "6.3" "5.7" "6.1" "8.3" "10.9" "5.9" "37.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-775611795353196892" "False" "Medium" "IsMasterProtein" "Q86XI2" "Condensin-2 complex subunit G2 OS=Homo sapiens OX=9606 GN=NCAPG2 PE=1 SV=1" "0.019" "False" "1.701" "1" "1" "1" "1" "1143" "130.9" "6.87" "1.76" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12422" "54892" "ENSG00000146918" "NCAPG2" "A4D228; hsa:54892; Q7Z3J9; Q86XI2; Q8WUG8; Q9BRX6; Q9H8S2; Q9H9K6" "Mesodermal commitment pathway" "Condensation of Prophase Chromosomes" "2" "0" "1.466" "1.034" "1.525" "1.419" "1.362" "1.640" "0.981" "1.270" "3.691" "41.0" "60.1" "42.4" "62.5" "58.2" "55.9" "67.3" "40.2" "52.1" "151.4" "" "" "" "" "" "" "" "" "" "" "24.5" "31.2" "23.5" "29.4" "27.0" "28.6" "31.3" "18.1" "28.3" "151.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9194436757358923865" "False" "Medium" "IsMasterProtein" "Q5W0V3" "FHF complex subunit HOOK interacting protein 2A OS=Homo sapiens OX=9606 GN=FHIP2A PE=1 SV=1" "0.019" "False" "1.700" "2" "1" "1" "1" "765" "86.5" "5.29" "0.00" "1" "" "" "" "Pf10257, Pf19311, Pf19314" "57700" "ENSG00000151553" "FHIP2A" "Q5H9P7; Q5W0V2; Q5W0V3; Q8IY76; Q9HCH2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6395049123037932349" "False" "Medium" "IsMasterProtein" "P30793" "GTP cyclohydrolase 1 OS=Homo sapiens OX=9606 GN=GCH1 PE=1 SV=1" "0.019" "False" "1.698" "3" "1" "1" "1" "250" "27.9" "8.56" "2.40" "1" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf01227" "2643" "ENSG00000131979" "GCH1" "hsa:2643; P30793; Q6FHY7; Q9Y4I8" "Ferroptosis" "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3509057874585176951" "False" "Medium" "IsMasterProtein" "Q9GZS1" "DNA-directed RNA polymerase I subunit RPA49 OS=Homo sapiens OX=9606 GN=POLR1E PE=1 SV=3" "0.019" "False" "1.694" "2" "1" "1" "1" "419" "47.2" "8.94" "1.88" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06870" "64425" "ENSG00000137054" "POLR1E" "hsa:64425; Q5VZT3; Q8NBA9; Q96L20; Q9GZS1" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome; Rubinstein-Taybi syndrome 1" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination" "9" "0" "1.082" "0.969" "0.588" "1.541" "1.551" "1.235" "0.897" "0.931" "3.261" "18.2" "19.7" "17.6" "10.7" "28.1" "28.2" "22.5" "16.3" "16.9" "59.3" "" "" "" "" "" "" "" "" "" "" "10.9" "10.2" "9.8" "5.0" "13.0" "14.5" "10.5" "7.3" "9.2" "59.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7222165964987125403" "False" "Medium" "IsMasterProtein" "P36954" "DNA-directed RNA polymerase II subunit RPB9 OS=Homo sapiens OX=9606 GN=POLR2I PE=1 SV=1" "0.019" "False" "1.694" "6" "1" "1" "1" "125" "14.5" "5.14" "0.00" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf02150" "5438" "ENSG00000105258" "POLR2I" "B2R5J2; hsa:5438; P36954; Q6NW05" "Pyrimidine metabolism; Eukaryotic transcription initiation" "mRNA Splicing - Major Pathway; Estrogen-dependent gene expression; PIWI-interacting RNA (piRNA) biogenesis; Processing of Capped Intron-Containing Pre-mRNA; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; MicroRNA (miRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "43" "0" "0.920" "1.121" "1.024" "1.211" "1.189" "1.330" "1.446" "1.369" "0.742" "19.9" "18.3" "22.3" "20.4" "24.1" "23.6" "26.4" "28.8" "27.2" "14.8" "" "" "" "" "" "" "" "" "" "" "11.9" "9.5" "12.3" "9.6" "11.2" "12.1" "12.3" "12.9" "14.8" "14.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1333795596038477477" "False" "Medium" "IsMasterProtein" "P62877" "E3 ubiquitin-protein ligase RBX1 OS=Homo sapiens OX=9606 GN=RBX1 PE=1 SV=1" "0.019" "False" "1.684" "7" "1" "3" "1" "108" "12.3" "6.96" "7.21" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12678" "9978" "ENSG00000100387" "RBX1" "B2RDY1; hsa:9978; P62877; Q8N6Z8; Q9D1S2; Q9WUK9; Q9Y254" "Cell cycle; Dual hijack model of Vif in HIV infection; TGF-beta signaling pathway; Type 2 papillary renal cell carcinoma; NRF2-ARE regulation; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Nucleotide excision repair; Hijack of ubiquitination by SARS-CoV-2; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 1p36 copy number variation syndrome" "Potential therapeutics for SARS; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Degradation of DVL; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of BACH1 activity; NOTCH1 Intracellular Domain Regulates Transcription; Formation of TC-NER Pre-Incision Complex; Prolactin receptor signaling; Evasion by RSV of host interferon responses; DNA Damage Recognition in GG-NER; Nuclear events stimulated by ALK signaling in cancer; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "48" "0" "1.187" "1.080" "1.180" "1.060" "1.061" "1.089" "1.248" "1.003" "0.719" "165.7" "196.7" "179.0" "195.4" "175.6" "175.9" "180.5" "206.8" "166.2" "119.1" "" "" "" "" "" "" "" "" "" "" "99.2" "102.2" "99.1" "91.8" "81.4" "90.0" "83.9" "92.8" "90.2" "119.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5271819707192533656" "False" "Medium" "IsMasterProtein" "Q9H7E9" "UPF0488 protein C8orf33 OS=Homo sapiens OX=9606 GN=C8orf33 PE=1 SV=1" "0.019" "False" "1.682" "5" "1" "1" "1" "229" "25.0" "9.95" "0.00" "1" "" "" "" "Pf15393" "65265" "ENSG00000182307; ENSG00000291362" "C8orf33" "A6NGC0; hsa:65265; Q96BT8; Q9H7E9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5356528915824417311" "False" "Medium" "IsMasterProtein" "Q7RTS9" "Dymeclin OS=Homo sapiens OX=9606 GN=DYM PE=1 SV=1" "0.019" "False" "1.681" "1" "1" "1" "1" "669" "75.9" "5.86" "0.00" "1" "cell organization and biogenesis;developmental processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf09742" "54808" "ENSG00000141627" "DYM" "A8K5I8; B2RCF9; B4DKI7; hsa:54808; Q3ZTS8; Q6P2P5; Q7RTS9; Q8N2M0; Q9BVE9; Q9NPU7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3465113943003846718" "False" "Medium" "IsMasterProtein" "Q5T9S5" "Coiled-coil domain-containing protein 18 OS=Homo sapiens OX=9606 GN=CCDC18 PE=1 SV=1" "0.019" "False" "1.681" "1" "1" "1" "1" "1454" "168.9" "5.66" "0.00" "1" "" "cytoskeleton;other cell component" "" "" "343099" "ENSG00000122483" "CCDC18" "hsa:343099; Q5T9S5; Q6ZU17" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8251896987743937176" "False" "Medium" "IsMasterProtein" "P53680" "AP-2 complex subunit sigma OS=Homo sapiens OX=9606 GN=AP2S1 PE=1 SV=2" "0.019" "False" "1.680" "5" "1" "2" "1" "142" "17.0" "6.18" "5.40" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "1175" "ENSG00000042753" "AP2S1" "B2R4Z4; hsa:1175; O75977; P53680; Q6PK67" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome" "MHC class II antigen presentation; Potential therapeutics for SARS; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "18" "0" "1.047" "0.954" "1.095" "1.073" "1.070" "1.059" "1.102" "1.062" "1.419" "206.0" "215.7" "196.6" "225.6" "221.0" "220.3" "218.1" "227.0" "218.8" "292.2" "" "" "" "" "" "" "" "" "" "" "123.3" "112.1" "108.9" "105.9" "102.5" "112.8" "101.4" "101.9" "118.7" "292.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3450691866042293765" "False" "Medium" "IsMasterProtein" "A2RRP1" "NBAS subunit of NRZ tethering complex OS=Homo sapiens OX=9606 GN=NBAS PE=1 SV=2" "0.019" "False" "1.679" "1" "1" "1" "1" "2371" "268.4" "5.96" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf08314, Pf15492" "51594" "ENSG00000151779" "NBAS" "A2RRP1; hsa:51594; O95790; Q2VPJ7; Q53TK6; Q86V39; Q8NFY8; Q9Y3W5" "" "COPI-dependent Golgi-to-ER retrograde traffic" "1" "0" "1.240" "1.108" "1.204" "1.623" "1.801" "0.767" "1.686" "1.096" "0.563" "20.4" "25.3" "22.6" "24.6" "33.1" "36.8" "15.7" "34.4" "22.4" "11.5" "" "" "" "" "" "" "" "" "" "" "12.2" "13.2" "12.5" "11.5" "15.4" "18.8" "7.3" "15.5" "12.1" "11.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8546786530734250007" "False" "Medium" "IsMasterProtein" "Q00325" "Solute carrier family 25 member 3 OS=Homo sapiens OX=9606 GN=SLC25A3 PE=1 SV=2" "0.019" "False" "1.674" "2" "1" "1" "1" "362" "40.1" "9.38" "2.19" "1" "transport" "plasma membrane;other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00153" "5250" "ENSG00000075415" "SLC25A3" "B3KS34; hsa:5250; Q00325; Q7Z7N7; Q96A03" "" "" "0" "0" "0.850" "0.971" "0.915" "1.077" "1.163" "0.875" "1.132" "1.112" "0.629" "86.8" "73.8" "84.3" "79.4" "93.5" "100.9" "75.9" "98.3" "96.5" "54.6" "" "" "" "" "" "" "" "" "" "" "51.9" "38.4" "46.7" "37.3" "43.4" "51.7" "35.3" "44.1" "52.4" "54.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5959854138225624200" "False" "Medium" "IsMasterProtein" "Q7Z6E9" "E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens OX=9606 GN=RBBP6 PE=1 SV=1" "0.019" "False" "1.669" "1" "1" "1" "1" "1792" "201.4" "9.64" "0.00" "1" "protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04564, Pf08783, Pf13696" "5930" "ENSG00000122257" "RBBP6" "Q147T5; Q15290; Q6DKH4; Q6P4C2; Q6YNC9; Q7Z6E8; Q7Z6E9; Q8N0V2; Q96PH3; Q9H3I8; Q9H5M5; Q9NPX4" "" "Antigen processing: Ubiquitination & Proteasome degradation; RHOBTB1 GTPase cycle" "2" "0" "1.206" "1.121" "1.410" "1.187" "1.191" "1.449" "1.504" "1.333" "0.890" "26.5" "31.9" "29.7" "37.3" "31.4" "31.5" "38.3" "39.8" "35.3" "23.6" "" "" "" "" "" "" "" "" "" "" "15.8" "16.6" "16.4" "17.5" "14.6" "16.1" "17.8" "17.9" "19.1" "23.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7727085808198553563" "False" "Medium" "IsMasterProtein" "P30291" "Wee1-like protein kinase OS=Homo sapiens OX=9606 GN=WEE1 PE=1 SV=2" "0.019" "False" "1.664" "2" "1" "1" "1" "646" "71.6" "6.77" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "7465" "ENSG00000166483" "WEE1" "B3KVE1; D3DQV0; hsa:7465; P30291" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control" "Factors involved in megakaryocyte development and platelet production; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Cyclin A/B1/B2 associated events during G2/M transition; Polo-like kinase mediated events; G2/M DNA replication checkpoint; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8034699390765478794" "False" "Medium" "IsMasterProtein" "Q9UID3" "Vacuolar protein sorting-associated protein 51 homolog OS=Homo sapiens OX=9606 GN=VPS51 PE=1 SV=2" "0.019" "False" "1.660" "2" "1" "1" "1" "782" "86.0" "6.47" "0.00" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08700" "738" "ENSG00000149823" "VPS51" "hsa:738; Q6PJV5; Q7L8A6; Q8WZ35; Q96DF4; Q96GR3; Q9UID3" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "1.365" "1.013" "0.724" "0.838" "1.097" "1.059" "0.287" "0.567" "5.286" "11.3" "15.4" "11.4" "8.2" "9.4" "12.3" "11.9" "3.2" "6.4" "59.5" "" "" "" "" "" "" "" "" "" "" "6.7" "8.0" "6.3" "3.8" "4.4" "6.3" "5.5" "1.4" "3.5" "59.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6366471573816439068" "False" "Medium" "IsMasterProtein" "P52179" "Myomesin-1 OS=Homo sapiens OX=9606 GN=MYOM1 PE=1 SV=2" "0.020" "False" "1.658" "1" "1" "3" "1" "1685" "187.5" "6.93" "5.86" "1" "developmental processes;signal transduction;other biological processes" "cytoskeleton" "other molecular function" "Pf00041, Pf07679" "8736" "ENSG00000101605" "MYOM1" "hsa:8736; P52179; Q14BD6; Q6H969; Q6ZUU0" "Striated muscle contraction pathway" "" "1" "0" "0.648" "0.690" "0.785" "0.531" "0.802" "0.629" "0.706" "0.569" "0.612" "65.2" "42.3" "45.0" "51.2" "34.6" "52.2" "41.0" "46.0" "37.1" "39.9" "" "" "" "" "" "" "" "" "" "" "39.0" "22.0" "24.9" "24.0" "16.0" "26.7" "19.1" "20.6" "20.1" "39.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4778122268276291111" "False" "Medium" "IsMasterProtein" "P49406" "Large ribosomal subunit protein bL19m OS=Homo sapiens OX=9606 GN=MRPL19 PE=1 SV=2" "0.020" "False" "1.658" "3" "1" "1" "1" "292" "33.5" "9.50" "1.67" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf01245" "9801" "ENSG00000115364" "MRPL19" "hsa:9801; P49406; Q53TX9; Q96Q52" "Cytoplasmic ribosomal proteins" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "1.272" "1.188" "1.151" "1.235" "0.858" "1.223" "0.711" "1.104" "2.628" "20.1" "25.5" "23.8" "23.1" "24.8" "17.2" "24.5" "14.3" "22.2" "52.7" "" "" "" "" "" "" "" "" "" "" "12.0" "13.3" "13.2" "10.8" "11.5" "8.8" "11.4" "6.4" "12.0" "52.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8242626749563967556" "False" "Medium" "IsMasterProtein" "Q9Y606" "Pseudouridylate synthase 1 homolog OS=Homo sapiens OX=9606 GN=PUS1 PE=1 SV=3" "0.020" "False" "1.656" "2" "1" "1" "1" "427" "47.4" "8.41" "2.53" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01416" "80324" "ENSG00000177192" "PUS1" "A8K877; B3KQC1; hsa:80324; Q8WYT2; Q9BU44; Q9Y606" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8076936007263184808" "False" "Medium" "IsMasterProtein" "O60662" "Kelch-like protein 41 OS=Homo sapiens OX=9606 GN=KLHL41 PE=1 SV=2" "0.020" "False" "1.654" "1" "1" "1" "1" "606" "68.0" "5.29" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "" "Pf00651, Pf01344, Pf07707" "10324" "ENSG00000239474" "KLHL41" "hsa:10324; O60662; Q53R42" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6341136208215643454" "False" "Medium" "IsMasterProtein" "Q6GYQ0" "Ral GTPase-activating protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=RALGAPA1 PE=1 SV=1" "0.020" "False" "1.648" "0" "1" "2" "1" "2036" "229.7" "6.19" "1.90" "1" "other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02145, Pf20412" "253959" "ENSG00000174373" "RALGAPA1" "A6NMA4; B9EK38; C5NU19; hsa:253959; O94960; Q6GYP9; Q6GYQ0; Q6ZT23; Q86YF3; Q86YF5; Q8ND69" "" "RHOH GTPase cycle" "1" "0" "1.136" "1.027" "1.193" "0.812" "0.988" "1.121" "1.037" "1.209" "0.791" "74.0" "84.0" "75.9" "88.2" "60.1" "73.1" "82.9" "76.7" "89.5" "58.5" "" "" "" "" "" "" "" "" "" "" "44.3" "43.7" "42.1" "41.4" "27.8" "37.4" "38.6" "34.4" "48.5" "58.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3191297454369684242" "False" "Medium" "IsMasterProtein" "Q8WZ42" "Titin OS=Homo sapiens OX=9606 GN=TTN PE=1 SV=4" "0.020" "False" "1.646" "0" "1" "4" "1" "34350" "3813.7" "6.35" "8.92" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus" "cytoskeletal activity;kinase activity;other molecular function" "Pf00041, Pf00069, Pf02818, Pf07679, Pf09042, Pf18362" "7273" "ENSG00000155657" "TTN" "A6NKB1; E7EQE6; E7ET18; hsa:7273; K7ENY1; Q10465; Q10466; Q15598; Q2XUS3; Q32Q60; Q4U1Z6; Q4ZG20; Q6NSG0; Q6PDB1; Q6PJP0; Q7KYM2; Q7KYN4; Q7KYN5; Q7LDM3; Q7Z2X3; Q8TCG8; Q8WZ42; Q8WZ51; Q8WZ52; Q8WZ53; Q8WZB3; Q92761; Q92762; Q9UD97; Q9UP84; Q9Y6L9" "Striated muscle contraction pathway; Cardiomyocyte signaling pathways converging on titin" "Platelet degranulation ; Striated Muscle Contraction" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3349657221176052038" "False" "Medium" "IsMasterProtein" "O00750" "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta OS=Homo sapiens OX=9606 GN=PIK3C2B PE=1 SV=2" "0.021" "False" "1.643" "1" "1" "1" "1" "1634" "184.7" "7.30" "0.00" "1" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00168, Pf00454, Pf00613, Pf00787, Pf00792, Pf00794" "5287" "ENSG00000133056" "PIK3C2B" "hsa:5287; O00750; O95666; Q5SW99" "Glioblastoma signaling pathways; S1P receptor signal transduction; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)" "Synthesis of PIPs at the plasma membrane" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9207268972416967358" "False" "Medium" "IsMasterProtein" "O15066" "Kinesin-like protein KIF3B OS=Homo sapiens OX=9606 GN=KIF3B PE=1 SV=1" "0.021" "False" "1.643" "1" "1" "1" "1" "747" "85.1" "7.69" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "9371" "ENSG00000101350" "KIF3B" "B2RMP4; B4DSR5; E1P5M5; hsa:9371; O15066" "" "Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Kinesins" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1788576308263676540" "False" "Medium" "IsMasterProtein" "Q9BUK6" "Protein misato homolog 1 OS=Homo sapiens OX=9606 GN=MSTO1 PE=1 SV=1" "0.021" "False" "1.641" "2" "1" "1" "1" "570" "61.8" "6.11" "1.61" "1" "cell organization and biogenesis" "other membranes;cytosol;mitochondrion;other cell component" "" "Pf10644, Pf14881" "55154" "ENSG00000125459" "MSTO1" "hsa:55154; Q53GR8; Q5CZ69; Q5T717; Q68CT6; Q7LBZ8; Q7Z3M7; Q7Z558; Q8TE05; Q9BUK6; Q9NQX2; Q9NVU4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-979600656900959777" "False" "Medium" "IsMasterProtein" "Q9HD40" "O-phosphoseryl-tRNA(Sec) selenium transferase OS=Homo sapiens OX=9606 GN=SEPSECS PE=1 SV=2" "0.021" "False" "1.637" "2" "1" "1" "1" "501" "55.7" "8.05" "0.00" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05889" "51091" "ENSG00000109618" "SEPSECS" "A8K8W1; hsa:51091; Q0D2P3; Q17RT1; Q9HD40; Q9NXZ5; Q9UGM9; Q9Y353" "Selenium metabolism and selenoproteins" "Selenocysteine synthesis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-352840310732152978" "False" "Medium" "IsMasterProtein" "Q8NFU3" "Thiosulfate:glutathione sulfurtransferase OS=Homo sapiens OX=9606 GN=TSTD1 PE=1 SV=3" "0.021" "False" "1.637" "6" "1" "1" "1" "115" "12.5" "6.07" "2.30" "1" "other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00581" "100131187" "ENSG00000215845" "TSTD1" "hsa:100131187; Q5SY48; Q5SY49; Q5SY50; Q5SY51; Q8NFU2; Q8NFU3; Q9BV22" "" "Sulfide oxidation to sulfate" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8995657341512938219" "False" "Medium" "IsMasterProtein" "P47914" "Large ribosomal subunit protein eL29 OS=Homo sapiens OX=9606 GN=RPL29 PE=1 SV=2" "0.021" "False" "1.634" "5" "1" "1" "1" "159" "17.7" "11.66" "2.26" "1" "protein metabolism;other metabolic processes;developmental processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01779" "6159" "ENSG00000162244" "RPL29" "A8K0H3; B2R4M8; hsa:6159; P47914; Q6IPY3" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4887773767884950166" "False" "Medium" "IsMasterProtein" "Q68DK7" "Male-specific lethal 1 homolog OS=Homo sapiens OX=9606 GN=MSL1 PE=1 SV=3" "0.022" "False" "1.625" "2" "1" "1" "1" "614" "67.1" "8.92" "0.00" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15275, Pf16801" "339287" "ENSG00000188895" "MSL1" "hsa:339287; Q0VF46; Q68DK7; Q69Z03" "" "HATs acetylate histones" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "High" "High" "1" "" "-646999670011784093" "False" "Medium" "IsMasterProtein" "Q96S55" "ATPase WRNIP1 OS=Homo sapiens OX=9606 GN=WRNIP1 PE=1 SV=2" "0.022" "False" "1.625" "2" "1" "1" "1" "665" "72.1" "6.10" "0.00" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00004, Pf12002, Pf16193, Pf18279" "56897" "ENSG00000124535" "WRNIP1" "B2RDB0; hsa:56897; Q53EP6; Q59ET8; Q5W0E2; Q5W0E4; Q8WV26; Q96S55; Q9H681; Q9NRJ6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4873150472968897924" "False" "Medium" "IsMasterProtein" "Q68DE3" "Basic helix-loop-helix domain-containing protein USF3 OS=Homo sapiens OX=9606 GN=USF3 PE=1 SV=4" "0.022" "False" "1.623" "0" "1" "1" "1" "2245" "241.5" "7.61" "2.26" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00010" "205717" "ENSG00000176542" "USF3" "hsa:205717; Q68DE3; Q7Z3L9; Q8IVF3; Q9H8T4" "" "" "0" "0" "1.132" "1.141" "1.072" "1.059" "1.096" "1.015" "1.154" "0.964" "0.832" "157.2" "178.0" "179.3" "168.5" "166.4" "172.3" "159.4" "181.3" "151.4" "130.7" "" "" "" "" "" "" "" "" "" "" "94.1" "92.5" "99.3" "79.1" "77.1" "88.2" "74.1" "81.4" "82.2" "130.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7270530672924286629" "False" "Medium" "IsMasterProtein" "Q86TM6" "E3 ubiquitin-protein ligase synoviolin OS=Homo sapiens OX=9606 GN=SYVN1 PE=1 SV=2" "0.022" "False" "1.620" "1" "1" "1" "1" "617" "67.6" "6.95" "1.83" "1" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf13639" "84447" "ENSG00000162298" "SYVN1" "hsa:84447; Q86TM6; Q8N3K3; Q8N6E8; Q96JL5; Q96PK3" "" "Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; ER Quality Control Compartment (ERQC); XBP1(S) activates chaperone genes" "4" "0" "0.943" "1.222" "0.975" "1.392" "1.109" "1.127" "1.242" "1.012" "0.756" "56.5" "53.2" "69.0" "55.0" "78.6" "62.6" "63.7" "70.1" "57.1" "42.7" "" "" "" "" "" "" "" "" "" "" "33.8" "27.7" "38.2" "25.8" "36.4" "32.1" "29.6" "31.5" "31.0" "42.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8750052983451588697" "False" "Medium" "IsMasterProtein" "O43166" "Signal-induced proliferation-associated 1-like protein 1 OS=Homo sapiens OX=9606 GN=SIPA1L1 PE=1 SV=4" "0.022" "False" "1.619" "1" "1" "2" "1" "1804" "199.9" "8.19" "0.00" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf00595, Pf02145, Pf11881, Pf21022" "26037" "ENSG00000197555" "SIPA1L1" "hsa:26037; J3KP19; O43166; O95321; Q9UDU4; Q9UNU4" "" "Neurexins and neuroligins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "High" "High" "Not Found" "1" "" "7327599600572382898" "False" "Medium" "IsMasterProtein" "P08473" "Neprilysin OS=Homo sapiens OX=9606 GN=MME PE=1 SV=2" "0.022" "False" "1.615" "1" "1" "1" "1" "750" "85.5" "5.73" "2.06" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01431, Pf05649" "4311" "ENSG00000196549" "MME" "A8K6U6; D3DNJ9; hsa:4311; P08473; Q3MIX4" "Alzheimer's disease and miRNA effects; Primary focal segmental glomerulosclerosis (FSGS); Alzheimer's disease" "Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins; Physiological factors" "6" "0" "0.997" "0.741" "1.387" "1.273" "1.162" "1.430" "1.289" "1.505" "0.806" "37.3" "37.2" "27.6" "51.7" "47.5" "43.3" "53.3" "48.0" "56.1" "30.1" "" "" "" "" "" "" "" "" "" "" "22.3" "19.3" "15.3" "24.3" "22.0" "22.2" "24.8" "21.6" "30.4" "30.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5224017387005900556" "False" "Medium" "IsMasterProtein" "Q9Y4A5" "Transformation/transcription domain-associated protein OS=Homo sapiens OX=9606 GN=TRRAP PE=1 SV=3" "0.022" "False" "1.612" "0" "1" "2" "1" "3859" "437.3" "8.19" "0.00" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00454, Pf02259, Pf20175, Pf20206" "8295" "ENSG00000196367" "TRRAP" "A4D265; hsa:8295; O75218; Q9Y4A5; Q9Y631; Q9Y6H4" "Rett syndrome" "Ub-specific processing proteases; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7072278322173443531" "False" "Medium" "IsMasterProtein" "Q8N371" "Bifunctional peptidase and arginyl-hydroxylase JMJD5 OS=Homo sapiens OX=9606 GN=KDM8 PE=1 SV=1" "0.022" "False" "1.612" "2" "1" "1" "1" "416" "47.2" "5.80" "1.71" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13621" "79831" "ENSG00000155666" "KDM8" "B4DLU9; hsa:79831; Q6VAK5; Q8N371; Q9H8B1" "" "Protein hydroxylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2915900051500808840" "False" "Medium" "IsMasterProtein" "Q5SXH7" "Pleckstrin homology domain-containing family S member 1 OS=Homo sapiens OX=9606 GN=PLEKHS1 PE=1 SV=4" "0.022" "False" "1.609" "2" "1" "1" "1" "465" "52.4" "5.20" "0.00" "1" "" "" "" "Pf00169" "79949" "ENSG00000148735" "PLEKHS1" "A8KA02; B3KX00; B6EDE1; hsa:79949; Q5SXH7; Q5SXH8; Q5SXI0; Q6ZQR5; Q8NE42; Q9H5D9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1413134168628784763" "False" "Medium" "IsMasterProtein" "Q9Y2Q0" "Phospholipid-transporting ATPase IA OS=Homo sapiens OX=9606 GN=ATP8A1 PE=1 SV=1" "0.022" "False" "1.600" "1" "1" "1" "1" "1164" "131.3" "6.84" "1.67" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00122, Pf13246, Pf16209, Pf16212" "10396" "ENSG00000124406" "ATP8A1" "hsa:10396; Q32M35; Q32M36; Q4W5J7; Q4W5P2; Q9Y2Q0" "Peptide GPCRs" "Neutrophil degranulation; Ion transport by P-type ATPases" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3683679323439236664" "False" "Medium" "IsMasterProtein" "Q6IPR3" "tRNA wybutosine-synthesizing protein 3 homolog OS=Homo sapiens OX=9606 GN=TYW3 PE=1 SV=2" "0.022" "False" "1.599" "4" "1" "1" "1" "259" "29.8" "7.68" "2.02" "1" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf02676" "127253" "ENSG00000162623" "TYW3" "B4DSP9; E9PGR7; hsa:127253; Q5HYJ0; Q6IPR3; Q8N7L1" "" "Synthesis of wybutosine at G37 of tRNA(Phe)" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2541081725476023529" "False" "Medium" "IsMasterProtein" "Q8NBJ7" "Inactive C-alpha-formylglycine-generating enzyme 2 OS=Homo sapiens OX=9606 GN=SUMF2 PE=1 SV=2" "0.022" "False" "1.599" "4" "1" "1" "1" "301" "33.8" "8.00" "0.00" "1" "" "ER/Golgi" "other molecular function" "Pf03781" "25870" "ENSG00000129103" "SUMF2" "B4DU41; B4DWQ0; hsa:25870; Q14DW5; Q53ZE3; Q8NBJ7; Q96BH2; Q9BRN3; Q9BWI1; Q9Y405" "" "Glycosphingolipid catabolism; The activation of arylsulfatases" "2" "0" "1.107" "1.114" "1.532" "1.334" "1.790" "1.378" "0.729" "1.474" "4.006" "16.3" "18.1" "18.2" "25.0" "21.8" "29.2" "22.5" "11.9" "24.1" "65.4" "" "" "" "" "" "" "" "" "" "" "9.8" "9.4" "10.1" "11.7" "10.1" "15.0" "10.5" "5.3" "13.1" "65.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8976168612742678464" "False" "Medium" "IsMasterProtein" "Q13243" "Serine/arginine-rich splicing factor 5 OS=Homo sapiens OX=9606 GN=SRSF5 PE=1 SV=1" "0.022" "False" "1.592" "3" "1" "1" "1" "272" "31.2" "11.59" "2.80" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf00076" "6430" "ENSG00000100650" "SRSF5" "hsa:6430; O14797; Q13243; Q16662; Q49AD6; Q6FGE0" "mRNA processing" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "6" "0" "0.705" "0.810" "0.834" "0.767" "0.913" "0.716" "0.831" "0.789" "0.509" "53.1" "37.4" "43.0" "44.2" "40.7" "48.5" "38.0" "44.1" "41.8" "27.0" "" "" "" "" "" "" "" "" "" "" "31.8" "19.4" "23.8" "20.8" "18.9" "24.8" "17.7" "19.8" "22.7" "27.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1379432049065423837" "False" "Medium" "IsMasterProtein" "O75143" "Autophagy-related protein 13 OS=Homo sapiens OX=9606 GN=ATG13 PE=1 SV=1" "0.023" "False" "1.591" "4" "1" "1" "1" "517" "56.5" "5.12" "0.00" "1" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf10033" "9776" "ENSG00000175224" "ATG13" "B4DFI4; D3DQQ1; D3DQQ2; E9PQZ8; hsa:9776; O75143; Q53EN6; Q9BRL3; Q9H8B0" "Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Host-pathogen interaction of human coronaviruses - autophagy; Autophagy; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "7547815190032953500" "False" "Medium" "IsMasterProtein" "Q5JXC2" "Migration and invasion-inhibitory protein OS=Homo sapiens OX=9606 GN=MIIP PE=1 SV=3" "0.023" "False" "1.583" "3" "1" "1" "1" "388" "42.8" "8.34" "0.00" "1" "other biological processes" "" "" "Pf15734" "60672" "ENSG00000116691" "MIIP" "C0KL22; hsa:60672; Q5JXC2; Q96HU6; Q9H839; Q9HA00" "HDAC6 interactions in the central nervous system" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4297435359722797915" "False" "Medium" "IsMasterProtein" "Q99755" "Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha OS=Homo sapiens OX=9606 GN=PIP5K1A PE=1 SV=1" "0.023" "False" "1.582" "2" "1" "1" "1" "562" "62.6" "8.21" "0.00" "1" "cell adhesion;cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01504" "8394" "ENSG00000143398" "PIP5K1A" "A8K4Q0; B4DIN0; hsa:8394; Q99754; Q99755; Q99756" "B cell receptor signaling pathway; Regulation of actin cytoskeleton" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "Not Found" "High" "High" "High" "High" "1" "" "-4875148632163355861" "False" "Medium" "IsMasterProtein" "Q9Y3D2" "Methionine-R-sulfoxide reductase B2, mitochondrial OS=Homo sapiens OX=9606 GN=MSRB2 PE=1 SV=2" "0.023" "False" "1.576" "5" "1" "1" "1" "182" "19.5" "8.63" "2.05" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf01641" "22921" "ENSG00000148450" "MSRB2" "hsa:22921; Q17R44; Q4G1C7; Q9Y3D2; Q9Y5W6" "Sulindac metabolic pathway; Methionine de novo and salvage pathway" "Protein repair" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4045429465415994492" "False" "Medium" "IsMasterProtein" "Q3ZCQ8" "Mitochondrial import inner membrane translocase subunit TIM50 OS=Homo sapiens OX=9606 GN=TIMM50 PE=1 SV=2" "0.023" "False" "1.573" "3" "1" "1" "1" "353" "39.6" "8.37" "2.02" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction" "other membranes;mitochondrion;nucleus" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf03031" "92609" "ENSG00000105197" "TIMM50" "hsa:92609; Q330K1; Q3ZCQ8; Q6QA00; Q96FJ5; Q96GY2; Q9H370" "" "Mitochondrial protein import" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "Not Found" "High" "High" "High" "1" "" "8206347650273111002" "False" "Medium" "IsMasterProtein" "Q9H7C9" "Mth938 domain-containing protein OS=Homo sapiens OX=9606 GN=AAMDC PE=1 SV=1" "0.023" "False" "1.572" "6" "1" "1" "1" "122" "13.3" "8.46" "1.69" "1" "other biological processes" "other cell component" "" "Pf04430" "28971" "ENSG00000087884" "AAMDC" "hsa:28971; Q96AQ4; Q9H7C9; Q9Y6B1" "" "" "0" "0" "0.978" "1.099" "0.894" "0.853" "1.205" "0.801" "1.127" "1.119" "0.656" "69.3" "67.8" "76.2" "62.0" "59.1" "83.5" "55.5" "78.1" "77.6" "45.5" "" "" "" "" "" "" "" "" "" "" "41.5" "35.2" "42.2" "29.1" "27.4" "42.8" "25.8" "35.1" "42.1" "45.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5667017434232915728" "False" "Medium" "IsMasterProtein" "Q9Y618" "Nuclear receptor corepressor 2 OS=Homo sapiens OX=9606 GN=NCOR2 PE=1 SV=3" "0.023" "False" "1.568" "0" "1" "1" "1" "2514" "273.5" "7.59" "0.00" "1" "transport;developmental processes;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00249, Pf15784" "9612" "ENSG00000196498" "NCOR2" "hsa:9612; O00613; O15416; O15421; Q13354; Q56D06; Q59GM0; Q9Y5U0; Q9Y618" "Androgen receptor signaling pathway; Adipogenesis; Aryl hydrocarbon receptor pathway; Notch signaling; Rett syndrome; Notch signaling pathway" "Cytoprotection by HMOX1; SUMOylation of transcription cofactors; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; HDACs deacetylate histones; Nuclear Receptor transcription pathway; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis" "23" "0" "1.265" "0.958" "1.943" "1.330" "1.297" "1.302" "0.954" "1.191" "1.051" "28.9" "36.6" "27.7" "56.2" "38.5" "37.5" "37.6" "27.6" "34.4" "30.4" "" "" "" "" "" "" "" "" "" "" "17.3" "19.0" "15.3" "26.4" "17.8" "19.2" "17.5" "12.4" "18.7" "30.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7513240538999229112" "False" "Medium" "IsMasterProtein" "O95136" "Sphingosine 1-phosphate receptor 2 OS=Homo sapiens OX=9606 GN=S1PR2 PE=1 SV=2" "0.023" "False" "1.565" "3" "1" "1" "1" "353" "38.8" "8.97" "0.00" "1" "cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00001" "9294" "ENSG00000267534" "S1PR2" "hsa:9294; O95136; Q86UN8" "Small ligand GPCRs; S1P receptor signal transduction; Sphingolipid metabolism in senescence" "G alpha (i) signalling events; Lysosphingolipid and LPA receptors" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200038646673232615" "False" "Medium" "IsMasterProtein" "Q9P287" "BRCA2 and CDKN1A-interacting protein OS=Homo sapiens OX=9606 GN=BCCIP PE=1 SV=1" "0.023" "False" "1.563" "2" "1" "1" "1" "314" "36.0" "4.61" "3.27" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus" "enzyme regulator activity;cytoskeletal activity" "Pf13862" "56647" "ENSG00000107949" "BCCIP" "B3KP45; hsa:56647; Q8ND15; Q96GC4; Q9P287; Q9P288" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7674938862773320945" "False" "Medium" "IsMasterProtein" "A3KMH1" "von Willebrand factor A domain-containing protein 8 OS=Homo sapiens OX=9606 GN=VWA8 PE=1 SV=2" "0.023" "False" "1.556" "0" "1" "1" "1" "1905" "214.7" "7.40" "0.00" "1" "" "mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07728" "23078" "ENSG00000102763" "VWA8" "A3KMH1; hsa:23078; O60310; Q5JTP6; Q5VW08; Q7Z6I9; Q86YC9; Q8N3E4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "121458031031999340" "False" "Medium" "IsMasterProtein" "P35232" "Prohibitin 1 OS=Homo sapiens OX=9606 GN=PHB1 PE=1 SV=1" "0.023" "False" "1.555" "3" "1" "1" "1" "272" "29.8" "5.76" "0.00" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01145" "5245" "ENSG00000167085" "PHB1" "B4DY47; hsa:5245; P35232; Q4VBQ0" "" "RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Processing of SMDT1" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2898803308841595735" "False" "Medium" "IsMasterProtein" "O00182" "Galectin-9 OS=Homo sapiens OX=9606 GN=LGALS9 PE=1 SV=2" "0.024" "False" "1.552" "2" "1" "1" "1" "355" "39.5" "9.17" "0.00" "1" "stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00337" "3965" "ENSG00000168961" "LGALS9" "A7VJG6; F8W9W4; hsa:3965; O00182; O14532; O75028; Q3B8N1; Q53FQ0; Q8WYQ7; Q9NQ58" "Vitamin D receptor pathway; Pleural mesothelioma; Immune infiltration in pancreatic cancer" "Interleukin-2 family signaling" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8268221381324165575" "False" "Medium" "IsMasterProtein" "Q96B96" "Lipid droplet assembly factor 1 OS=Homo sapiens OX=9606 GN=LDAF1 PE=1 SV=2" "0.024" "False" "1.551" "5" "1" "1" "1" "161" "17.5" "5.06" "2.08" "1" "cell organization and biogenesis" "other membranes;ER/Golgi;other cell component" "" "Pf16015" "57146" "ENSG00000011638" "LDAF1" "A6NMA9; B4DEC1; hsa:57146; O00323; Q96B96" "" "" "0" "0" "0.867" "0.838" "0.936" "0.874" "0.957" "0.832" "1.124" "1.023" "0.852" "39.4" "34.1" "33.0" "36.9" "34.4" "37.7" "32.8" "44.3" "40.3" "33.6" "" "" "" "" "" "" "" "" "" "" "23.6" "17.7" "18.3" "17.3" "16.0" "19.3" "15.2" "19.9" "21.9" "33.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5572152547917971737" "False" "Medium" "IsMasterProtein" "Q5T3J3" "Ligand-dependent nuclear receptor-interacting factor 1 OS=Homo sapiens OX=9606 GN=LRIF1 PE=1 SV=1" "0.024" "False" "1.551" "1" "1" "2" "1" "769" "84.5" "9.72" "3.74" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus" "other molecular function" "Pf15741" "55791" "ENSG00000121931" "LRIF1" "hsa:55791; Q5T3J3; Q86XS4; Q8N3B6; Q96HT4; Q9NUM5; Q9NV32" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4929708673540461466" "False" "Medium" "IsMasterProtein" "Q9UHP3" "Ubiquitin carboxyl-terminal hydrolase 25 OS=Homo sapiens OX=9606 GN=USP25 PE=1 SV=4" "0.024" "False" "1.550" "1" "1" "2" "1" "1055" "122.1" "5.34" "3.36" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf00443, Pf02809" "29761" "ENSG00000155313" "USP25" "C0LSZ0; hsa:29761; Q6DHZ9; Q9H9W1; Q9UHP3" "" "Ub-specific processing proteases" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1831156275587946455" "False" "Medium" "IsMasterProtein" "Q7Z401" "C-myc promoter-binding protein OS=Homo sapiens OX=9606 GN=DENND4A PE=1 SV=2" "0.024" "False" "1.549" "1" "1" "1" "1" "1863" "209.1" "7.31" "1.77" "1" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf02141, Pf03455, Pf03456" "10260" "ENSG00000174485" "DENND4A" "E7EPL3; hsa:10260; Q14655; Q7Z401; Q86T77; Q8IVX2; Q8NB93" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "0.814" "1.141" "1.149" "1.334" "0.870" "1.295" "1.067" "1.155" "1.239" "26.5" "21.5" "30.2" "30.4" "35.3" "23.0" "34.3" "28.2" "30.5" "32.8" "" "" "" "" "" "" "" "" "" "" "15.8" "11.2" "16.7" "14.3" "16.4" "11.8" "15.9" "12.7" "16.6" "32.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6652011194005899795" "False" "Medium" "IsMasterProtein" "P29083" "General transcription factor IIE subunit 1 OS=Homo sapiens OX=9606 GN=GTF2E1 PE=1 SV=2" "0.024" "False" "1.546" "2" "1" "1" "1" "439" "49.4" "4.82" "1.84" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf02002, Pf08271, Pf11521" "2960" "ENSG00000153767" "GTF2E1" "hsa:2960; P29083; Q16103" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5196394549713774835" "False" "Medium" "IsMasterProtein" "Q69YU5" "Ubiquinol-cytochrome c reductase complex assembly factor 6 OS=Homo sapiens OX=9606 GN=UQCC6 PE=1 SV=2" "0.024" "False" "1.546" "10" "1" "1" "1" "71" "8.0" "9.16" "1.68" "1" "cell organization and biogenesis" "other membranes;mitochondrion" "" "Pf14990" "728568" "ENSG00000204954" "UQCC6" "hsa:728568; Q69YU5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1353658345851562217" "False" "Medium" "IsMasterProtein" "Q9BR76" "Coronin-1B OS=Homo sapiens OX=9606 GN=CORO1B PE=1 SV=1" "0.024" "False" "1.545" "1" "1" "1" "1" "489" "54.2" "5.88" "2.45" "1" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf16300" "57175" "ENSG00000172725" "CORO1B" "B2RD45; hsa:57175; Q9BR76" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "67481981950008454" "False" "Medium" "IsMasterProtein" "Q7Z2Q7" "Leucine-rich repeat-containing protein 70 OS=Homo sapiens OX=9606 GN=LRRC70 PE=1 SV=1" "0.024" "False" "1.540" "3" "1" "1" "1" "622" "70.3" "8.76" "0.00" "1" "other biological processes" "plasma membrane;other membranes" "" "Pf13855" "100130733" "ENSG00000186105" "LRRC70" "hsa:100130733; Q6ZWI5; Q7Z2Q7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4845049006096107700" "False" "Medium" "IsMasterProtein" "Q8TCT7" "Signal peptide peptidase-like 2B OS=Homo sapiens OX=9606 GN=SPPL2B PE=1 SV=2" "0.024" "False" "1.539" "2" "1" "1" "1" "592" "64.6" "8.32" "0.00" "1" "protein metabolism;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf02225, Pf04258" "56928" "ENSG00000005206" "SPPL2B" "D6W609; hsa:56928; O60365; Q567S3; Q8IUH9; Q8TCT7; Q9BUY6; Q9H3M4; Q9NPN2; Q9P1Z6" "" "Regulation of TNFR1 signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "Not Found" "High" "High" "High" "High" "High" "High" "Not Found" "1" "" "4345096920380690584" "False" "Medium" "IsMasterProtein" "Q68CZ6" "HAUS augmin-like complex subunit 3 OS=Homo sapiens OX=9606 GN=HAUS3 PE=1 SV=1" "0.024" "False" "1.538" "2" "1" "1" "1" "603" "69.6" "5.55" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf14932" "79441" "ENSG00000214367" "HAUS3" "B4DF64; hsa:79441; O43606; Q68CZ6; Q8TAZ5; Q9BTJ9" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8250154090209623680" "False" "Medium" "IsMasterProtein" "Q9H2W6" "Large ribosomal subunit protein mL46 OS=Homo sapiens OX=9606 GN=MRPL46 PE=1 SV=1" "0.024" "False" "1.538" "3" "1" "1" "1" "279" "31.7" "7.05" "2.03" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "other molecular function" "Pf11788" "26589" "ENSG00000259494" "MRPL46" "B2RD75; hsa:26589; Q9H2W6; Q9HBU8" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3239366280692976916" "False" "Medium" "IsMasterProtein" "O14920" "Inhibitor of nuclear factor kappa-B kinase subunit beta OS=Homo sapiens OX=9606 GN=IKBKB PE=1 SV=1" "0.024" "False" "1.534" "1" "1" "1" "1" "756" "86.5" "5.78" "2.57" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf12179, Pf18397" "3551" "ENSG00000104365" "IKBKB" "B4DZ30; B4E0U4; hsa:3551; O14920; O75327" "Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; Apoptosis; Polycystic kidney disease pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Nonalcoholic fatty liver disease; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; Acute myeloid leukemia; T-cell receptor signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; PKR-mediated signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling" "91" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1706468280429092974" "False" "Medium" "IsMasterProtein" "Q9Y3S2" "Zinc finger protein 330 OS=Homo sapiens OX=9606 GN=ZNF330 PE=1 SV=1" "0.024" "False" "1.533" "3" "1" "1" "1" "320" "36.2" "6.16" "0.00" "1" "" "nucleus;other cell component" "other molecular function" "Pf06524" "27309" "ENSG00000109445" "ZNF330" "B2RDA3; hsa:27309; Q9Y3S2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1010351863231639578" "False" "Medium" "IsMasterProtein" "Q8IW41" "MAP kinase-activated protein kinase 5 OS=Homo sapiens OX=9606 GN=MAPKAPK5 PE=1 SV=2" "0.024" "False" "1.533" "4" "1" "1" "1" "473" "54.2" "7.78" "0.00" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8550" "ENSG00000089022" "MAPKAPK5" "B3KVA5; hsa:8550; O60491; Q86X46; Q8IW41; Q9BVX9; Q9UG86" "MAPK signaling pathway; VEGFA-VEGFR2 signaling; p38 MAPK signaling pathway" "MAPK6/MAPK4 signaling; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7072952226669663131" "False" "Medium" "IsMasterProtein" "P08648" "Integrin alpha-5 OS=Homo sapiens OX=9606 GN=ITGA5 PE=1 SV=2" "0.024" "False" "1.530" "1" "1" "1" "1" "1049" "114.5" "5.77" "0.00" "1" "cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01839, Pf08441, Pf20805, Pf20806" "3678" "ENSG00000161638" "ITGA5" "hsa:3678; P08648; Q96HA5" "Integrin-mediated cell adhesion; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ebola virus infection in host; Epithelial to mesenchymal transition in colorectal cancer; CCL18 signaling pathway; GDNF signaling; TROP2 regulatory signaling" "Cell surface interactions at the vascular wall; Integrin cell surface interactions; GPER1 signaling; Signal transduction by L1; RUNX2 regulates genes involved in cell migration; Fibronectin matrix formation; Elastic fibre formation" "17" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2299489419539549984" "False" "Medium" "IsMasterProtein" "Q9HCE3" "Zinc finger protein 532 OS=Homo sapiens OX=9606 GN=ZNF532 PE=1 SV=2" "0.025" "False" "1.526" "1" "1" "1" "1" "1301" "141.6" "8.65" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13912, Pf16622" "55205" "ENSG00000074657" "ZNF532" "hsa:55205; Q4G0V6; Q7L7Z7; Q96QR7; Q9HCE3; Q9NVJ6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3245620141315838438" "False" "Medium" "IsMasterProtein" "P17036" "Zinc finger protein 3 OS=Homo sapiens OX=9606 GN=ZNF3 PE=1 SV=3" "0.025" "False" "1.526" "4" "1" "1" "1" "446" "50.9" "7.52" "2.27" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "7551" "ENSG00000166526" "ZNF3" "D6W5U0; hsa:7551; P13683; P17036; Q9HBR4; Q9NNX8; Q9NXJ1; Q9UC15; Q9UC16" "" "Generic Transcription Pathway" "1" "0" "1.051" "0.739" "0.730" "0.994" "1.161" "0.503" "1.104" "0.878" "0.398" "30.2" "31.7" "22.3" "22.0" "30.0" "35.0" "15.2" "33.3" "26.5" "12.0" "" "" "" "" "" "" "" "" "" "" "18.0" "16.5" "12.3" "10.3" "13.9" "17.9" "7.1" "15.0" "14.4" "12.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2204752013873116397" "False" "Medium" "IsMasterProtein" "Q8IV20" "Purine nucleoside phosphorylase LACC1 OS=Homo sapiens OX=9606 GN=LACC1 PE=1 SV=1" "0.025" "False" "1.525" "3" "1" "1" "1" "430" "47.7" "7.06" "1.67" "1" "stress response;signal transduction;other biological processes" "ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf02578" "144811" "ENSG00000179630" "LACC1" "A2A3Z6; hsa:144811; Q8IV20; Q8N8X5" "" "" "0" "0" "1.329" "0.918" "1.288" "1.388" "1.309" "1.396" "1.425" "0.952" "1.452" "22.1" "29.4" "20.3" "28.5" "30.7" "29.0" "30.9" "31.5" "21.1" "32.1" "" "" "" "" "" "" "" "" "" "" "13.2" "15.3" "11.3" "13.4" "14.2" "14.8" "14.4" "14.2" "11.4" "32.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3879752315455634749" "False" "Medium" "IsMasterProtein" "O43822" "Cilia- and flagella-associated protein 410 OS=Homo sapiens OX=9606 GN=CFAP410 PE=1 SV=1" "0.025" "False" "1.525" "6" "1" "4" "1" "256" "28.3" "7.34" "0.00" "1" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "" "" "755" "ENSG00000160226" "CFAP410" "A8MPS9; O14993; O43822; Q8N5X6; Q99837; Q99838" "Ciliopathies; Bardet-Biedl syndrome" "" "2" "0" "1.067" "1.132" "1.809" "1.619" "1.615" "1.280" "1.353" "1.428" "1.064" "16.2" "17.3" "18.3" "29.3" "26.2" "26.1" "20.7" "21.9" "23.1" "17.2" "" "" "" "" "" "" "" "" "" "" "9.7" "9.0" "10.2" "13.7" "12.1" "13.4" "9.6" "9.8" "12.5" "17.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "575665869234459474" "False" "Medium" "IsMasterProtein" "P42331" "Rho GTPase-activating protein 25 OS=Homo sapiens OX=9606 GN=ARHGAP25 PE=1 SV=2" "0.025" "False" "1.525" "2" "1" "1" "1" "645" "73.4" "6.37" "0.00" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane" "enzyme regulator activity" "Pf00169, Pf00620" "9938" "ENSG00000163219" "ARHGAP25" "A8K2Y1; B7Z498; E9PFQ7; G5E9G2; hsa:9938; P42331; Q8IXQ2" "" "RAC1 GTPase cycle" "1" "0" "0.697" "0.968" "1.217" "1.106" "0.681" "1.169" "0.444" "1.151" "4.395" "13.9" "9.7" "13.5" "16.9" "15.4" "9.5" "16.3" "6.2" "16.0" "61.1" "" "" "" "" "" "" "" "" "" "" "8.3" "5.0" "7.5" "8.0" "7.1" "4.9" "7.6" "2.8" "8.7" "61.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7425401848780502306" "False" "Medium" "IsMasterProtein" "Q8NDW4" "Zinc finger protein 248 OS=Homo sapiens OX=9606 GN=ZNF248 PE=1 SV=1" "0.025" "False" "1.524" "2" "1" "1" "1" "579" "67.0" "8.25" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "57209" "ENSG00000198105" "ZNF248" "hsa:57209; Q8NDV8; Q8NDW4; Q9UMP3" "" "Generic Transcription Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5057410005729893010" "False" "Medium" "IsMasterProtein" "Q7Z4Q2" "HEAT repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=HEATR3 PE=1 SV=2" "0.025" "False" "1.503" "1" "1" "1" "1" "680" "74.5" "5.11" "2.07" "1" "transport;other biological processes" "" "other molecular function" "Pf13513" "55027" "ENSG00000155393" "HEATR3" "A8K1N4; hsa:55027; Q7Z4Q2; Q8N525; Q8WV56; Q96CC9; Q9NWN7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4097484419734302186" "False" "Medium" "IsMasterProtein" "Q9UBL3" "Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Homo sapiens OX=9606 GN=ASH2L PE=1 SV=1" "0.025" "False" "1.501" "1" "1" "1" "1" "628" "68.7" "5.69" "1.93" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00622, Pf21198, Pf21257" "9070" "ENSG00000129691" "ASH2L" "A8K7C3; D3DSW9; hsa:9070; O60659; O60660; Q96B62; Q9UBL3" "Kleefstra syndrome" "Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "7" "0" "0.968" "1.013" "1.313" "0.945" "1.303" "0.994" "1.273" "1.315" "2.739" "32.1" "31.1" "32.5" "42.2" "30.4" "41.9" "31.9" "40.9" "42.3" "88.0" "" "" "" "" "" "" "" "" "" "" "19.2" "16.2" "18.0" "19.8" "14.1" "21.4" "14.8" "18.4" "22.9" "88.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1619272264168287387" "False" "Medium" "IsMasterProtein" "Q8WVT3" "Trafficking protein particle complex subunit 12 OS=Homo sapiens OX=9606 GN=TRAPPC12 PE=1 SV=3" "0.025" "False" "1.497" "2" "1" "1" "1" "735" "79.3" "4.91" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf13174, Pf14559" "51112" "ENSG00000171853" "TRAPPC12" "B3KV01; D6W4Y2; hsa:51112; Q8WVT3; Q8WVW1; Q9Y395" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "0.879" "1.340" "1.100" "1.038" "1.021" "1.193" "0.900" "1.213" "1.908" "17.6" "15.4" "23.5" "19.3" "18.2" "18.0" "21.0" "15.8" "21.3" "33.5" "" "" "" "" "" "" "" "" "" "" "10.5" "8.0" "13.0" "9.1" "8.5" "9.2" "9.8" "7.1" "11.6" "33.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4311553193835580120" "False" "Medium" "IsMasterProtein" "P56556" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 OS=Homo sapiens OX=9606 GN=NDUFA6 PE=1 SV=4" "0.025" "False" "1.496" "6" "1" "1" "1" "128" "15.1" "9.98" "1.68" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport" "other membranes;mitochondrion" "transporter activity" "Pf13233" "4700" "ENSG00000184983; ENSG00000272765; ENSG00000273397; ENSG00000277365; ENSG00000281013" "NDUFA6" "B2RE54; hsa:4700; O43675; P56556; Q6FGW0; Q6IBT8; Q6IC39" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7748730165992048021" "False" "Medium" "IsMasterProtein" "Q6UWE0" "E3 ubiquitin-protein ligase LRSAM1 OS=Homo sapiens OX=9606 GN=LRSAM1 PE=1 SV=1" "0.025" "False" "1.494" "1" "1" "1" "1" "723" "83.5" "5.94" "0.00" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf07647, Pf13855, Pf13920" "90678" "ENSG00000148356" "LRSAM1" "Q5VVV0; Q6UWE0; Q8NB40; Q96GT5; Q96MX5; Q96MZ7" "Intracellular trafficking proteins involved in CMT neuropathy" "Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3689423794866279404" "False" "Medium" "IsMasterProtein" "Q8N8A2" "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B OS=Homo sapiens OX=9606 GN=ANKRD44 PE=1 SV=3" "0.025" "False" "1.490" "1" "1" "1" "1" "993" "107.5" "6.30" "0.00" "1" "" "" "" "Pf12796" "91526" "ENSG00000065413" "ANKRD44" "hsa:91526; Q53SL9; Q6P480; Q86VL5; Q8IZ72; Q8N8A2; Q9UFA4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1063370880291225048" "False" "Medium" "IsMasterProtein" "Q9UNN4" "TFIIA-alpha and beta-like factor OS=Homo sapiens OX=9606 GN=GTF2A1L PE=1 SV=2" "0.025" "False" "1.490" "1" "1" "1" "1" "478" "52.4" "4.73" "2.05" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03153" "11036" "ENSG00000242441" "GTF2A1L" "B4DY14; hsa:11036; Q53FD9; Q5D050; Q9UNN4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5357648313694038384" "False" "Medium" "IsMasterProtein" "Q8IUD2" "ELKS/Rab6-interacting/CAST family member 1 OS=Homo sapiens OX=9606 GN=ERC1 PE=1 SV=1" "0.026" "False" "1.476" "1" "1" "1" "1" "1116" "128.0" "5.97" "0.00" "1" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf09457, Pf10174" "23085" "ENSG00000082805" "ERC1" "A2RU77; A7E295; D3DUP7; D3DUP8; hsa:23085; Q6NVK2; Q8IUD2; Q8IUD3; Q8IUD4; Q8IUD5; Q8NAS1; Q9NXN5; Q9UIK7; Q9UPS1" "Cell lineage map for neuronal differentiation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2036911108115043510" "False" "Medium" "IsMasterProtein" "Q96F86" "Enhancer of mRNA-decapping protein 3 OS=Homo sapiens OX=9606 GN=EDC3 PE=1 SV=1" "0.026" "False" "1.474" "2" "1" "2" "1" "508" "56.0" "7.11" "1.77" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf03853, Pf09532, Pf12701, Pf16598" "80153" "ENSG00000179151" "EDC3" "B3KPH0; D3DW61; hsa:80153; Q96F86; Q9H797" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5869916031675078190" "False" "Medium" "IsMasterProtein" "O95486" "Protein transport protein Sec24A OS=Homo sapiens OX=9606 GN=SEC24A PE=1 SV=2" "0.026" "False" "1.473" "1" "1" "1" "1" "1093" "119.7" "7.66" "1.90" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10802" "ENSG00000113615" "SEC24A" "A8MVW3; hsa:10802; O95486; Q8WUV2; Q96GP7" "Sterol regulatory element-binding proteins (SREBP) signaling" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3414895648230328268" "False" "Medium" "IsMasterProtein" "Q92667" "A-kinase anchor protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=AKAP1 PE=1 SV=1" "0.026" "False" "1.472" "2" "1" "1" "1" "903" "97.3" "4.94" "0.00" "1" "stress response;other biological processes" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf00013, Pf00567" "8165" "ENSG00000121057" "AKAP1" "A8K8Q1; D3DTZ0; hsa:8165; Q13320; Q92667; Q9BW14" "G protein signaling pathways" "Factors involved in megakaryocyte development and platelet production; Mitochondrial calcium ion transport" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-203379576220599078" "False" "Medium" "IsMasterProtein" "Q13158" "FAS-associated death domain protein OS=Homo sapiens OX=9606 GN=FADD PE=1 SV=1" "0.026" "False" "1.471" "3" "1" "1" "1" "208" "23.3" "5.69" "2.45" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00531, Pf01335" "8772" "ENSG00000168040" "FADD" "hsa:8772; Q13158; Q14866; Q6IBR4" "TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Nanoparticle triggered regulated necrosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Alzheimer's disease; Toll-like receptor signaling pathway" "Regulation of TNFR1 signaling; TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TRAIL signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TLR3-mediated TICAM1-dependent programmed cell death; TNFR1-induced proapoptotic signaling; FasL/ CD95L signaling; Defective RIPK1-mediated regulated necrosis" "33" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9103143806185528671" "False" "Medium" "IsMasterProtein" "Q86UA1" "Pre-mRNA-processing factor 39 OS=Homo sapiens OX=9606 GN=PRPF39 PE=1 SV=3" "0.027" "False" "1.467" "1" "1" "1" "1" "669" "78.4" "5.40" "1.88" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "" "55015" "ENSG00000185246" "PRPF39" "hsa:55015; Q08AL1; Q08AL2; Q86UA1; Q9NUU5" "" "" "0" "0" "1.229" "1.116" "1.556" "0.857" "1.323" "1.281" "0.956" "1.234" "4.467" "35.9" "44.1" "40.0" "55.8" "30.7" "47.5" "46.0" "34.3" "44.3" "160.2" "" "" "" "" "" "" "" "" "" "" "21.5" "22.9" "22.2" "26.2" "14.2" "24.3" "21.4" "15.4" "24.0" "160.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1167802630562767288" "False" "Medium" "IsMasterProtein" "P42857" "Neuronal vesicle trafficking-associated protein 1 OS=Homo sapiens OX=9606 GN=NSG1 PE=1 SV=1" "0.027" "False" "1.466" "4" "1" "1" "1" "185" "20.9" "5.72" "1.96" "1" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf06387" "27065" "ENSG00000168824" "NSG1" "B4DXC5; hsa:27065; P42857; Q49AQ1" "" "" "0" "0" "0.998" "1.062" "1.519" "1.198" "1.207" "1.463" "1.179" "1.280" "0.572" "32.0" "31.9" "34.0" "48.6" "38.3" "38.6" "46.8" "37.7" "40.9" "18.3" "" "" "" "" "" "" "" "" "" "" "19.1" "16.6" "18.8" "22.8" "17.8" "19.8" "21.7" "16.9" "22.2" "18.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8312057505130700222" "False" "Medium" "IsMasterProtein" "P06865" "Beta-hexosaminidase subunit alpha OS=Homo sapiens OX=9606 GN=HEXA PE=1 SV=2" "0.027" "False" "1.465" "1" "1" "1" "1" "529" "60.7" "5.16" "2.42" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00728, Pf14845" "3073" "ENSG00000213614" "HEXA" "B4DKE7; E7ENH7; hsa:3073; P06865; Q53HS8; Q6AI32" "Degradation pathway of sphingolipids, including diseases; Glycosaminoglycan degradation" "CS/DS degradation; Hyaluronan uptake and degradation; Glycosphingolipid catabolism; Keratan sulfate degradation; Defective HEXA causes GM2G1" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4701389145220405334" "False" "Medium" "IsMasterProtein" "Q7RTY7" "Ovochymase-1 OS=Homo sapiens OX=9606 GN=OVCH1 PE=1 SV=3" "0.027" "False" "1.463" "1" "1" "3" "1" "1134" "124.9" "8.37" "0.00" "1" "protein metabolism" "non-structural extracellular" "other molecular function" "Pf00089, Pf00431" "" "ENSG00000187950" "OVCH1" "H0YH00; Q7RTY7" "" "" "0" "0" "0.898" "0.774" "1.738" "1.484" "1.301" "1.935" "0.838" "0.870" "1.273" "15.5" "13.9" "12.0" "27.0" "23.0" "20.2" "30.0" "13.0" "13.5" "19.8" "" "" "" "" "" "" "" "" "" "" "9.3" "7.2" "6.7" "12.7" "10.7" "10.3" "14.0" "5.8" "7.3" "19.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6098713629868852920" "False" "Medium" "IsMasterProtein" "Q12772" "Sterol regulatory element-binding protein 2 OS=Homo sapiens OX=9606 GN=SREBF2 PE=1 SV=2" "0.027" "False" "1.458" "1" "1" "1" "1" "1141" "123.6" "8.40" "0.00" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "6721" "ENSG00000198911" "SREBF2" "hsa:6721; Q05BD5; Q12772; Q6GTH7; Q86V36; Q9UH04" "Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Angiopoietin-like protein 8 regulatory pathway; 22q11.2 copy number variation syndrome; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways" "Activation of gene expression by SREBF (SREBP); PPARA activates gene expression; Cholesterol biosynthesis; Transcriptional regulation of white adipocyte differentiation; EGR2 and SOX10-mediated initiation of Schwann cell myelination" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-501406145012788137" "False" "Medium" "IsMasterProtein" "Q9H2K0" "Translation initiation factor IF-3, mitochondrial OS=Homo sapiens OX=9606 GN=MTIF3 PE=1 SV=4" "0.028" "False" "1.456" "3" "1" "1" "1" "278" "31.7" "9.69" "1.86" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "translation activity;nucleic acid binding activity" "Pf05198" "219402" "ENSG00000122033" "MTIF3" "hsa:219402; Q05BL8; Q5W0V0; Q86X68; Q9H2K0" "" "Mitochondrial translation initiation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2592776449693665757" "False" "Medium" "IsMasterProtein" "O95455" "dTDP-D-glucose 4,6-dehydratase OS=Homo sapiens OX=9606 GN=TGDS PE=1 SV=1" "0.028" "False" "1.455" "2" "1" "1" "1" "350" "40.2" "6.60" "2.23" "1" "other metabolic processes" "" "other molecular function" "Pf16363" "23483" "ENSG00000088451" "TGDS" "hsa:23483; O95455; Q05DQ3; Q2TU31; Q5T3Z2; Q9H1T9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7273003467290879098" "False" "Medium" "IsMasterProtein" "Q9UNE7" "E3 ubiquitin-protein ligase CHIP OS=Homo sapiens OX=9606 GN=STUB1 PE=1 SV=2" "0.028" "False" "1.453" "4" "1" "1" "1" "303" "34.8" "5.87" "0.00" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf04564, Pf12895, Pf18391" "10273" "ENSG00000103266" "STUB1" "A2IDB9; O60526; Q969U2; Q9HBT1; Q9UNE7" "Androgen receptor signaling pathway; Parkin-ubiquitin proteasomal system pathway; HDAC6 interactions in the central nervous system" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of TNFR1 signaling; Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Downregulation of TGF-beta receptor signaling" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9086652691068798717" "False" "Medium" "IsMasterProtein" "P51970" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 OS=Homo sapiens OX=9606 GN=NDUFA8 PE=1 SV=3" "0.028" "False" "1.452" "4" "1" "1" "1" "172" "20.1" "7.65" "2.94" "1" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf06747" "4702" "ENSG00000119421" "NDUFA8" "B1AM93; hsa:4702; P51970; Q9Y6N0" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "0.999" "1.161" "1.036" "1.193" "0.914" "1.197" "0.946" "1.082" "2.000" "219.8" "219.6" "255.3" "227.8" "262.2" "200.9" "263.1" "207.9" "237.8" "439.6" "" "" "" "" "" "" "" "" "" "" "131.5" "114.1" "141.4" "106.9" "121.5" "102.8" "122.3" "93.3" "129.0" "439.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2869722740218249638" "False" "Medium" "IsMasterProtein" "Q9Y6M4" "Casein kinase I isoform gamma-3 OS=Homo sapiens OX=9606 GN=CSNK1G3 PE=1 SV=2" "0.028" "False" "1.451" "2" "1" "1" "1" "447" "51.4" "9.22" "2.13" "1" "cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12605" "1456" "ENSG00000151292" "CSNK1G3" "A8K040; B4DSH2; B7Z9Q4; E7EVD0; hsa:1456; Q86WZ7; Q9Y6M3; Q9Y6M4" "Hedgehog signaling pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "433749903708797592" "False" "Medium" "IsMasterProtein" "Q8NB46" "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C OS=Homo sapiens OX=9606 GN=ANKRD52 PE=1 SV=3" "0.028" "False" "1.451" "1" "1" "1" "1" "1076" "115.0" "6.48" "1.78" "1" "" "" "" "Pf00023, Pf12796" "283373" "ENSG00000139645" "ANKRD52" "A6NE79; B1Q2K2; hsa:283373; Q8NB46" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2974291959383986730" "False" "Medium" "IsMasterProtein" "Q9UL33" "Trafficking protein particle complex subunit 2-like protein OS=Homo sapiens OX=9606 GN=TRAPPC2L PE=1 SV=1" "0.028" "False" "1.451" "6" "1" "1" "1" "140" "16.1" "6.77" "2.00" "1" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04628" "51693" "ENSG00000167515" "TRAPPC2L" "B2R4M9; hsa:51693; Q6ZTA7; Q9NZZ4; Q9UL33" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "0.967" "1.034" "1.104" "0.834" "0.952" "1.004" "1.187" "0.918" "3.279" "49.0" "47.3" "50.6" "54.0" "40.8" "46.6" "49.1" "58.1" "45.0" "160.5" "" "" "" "" "" "" "" "" "" "" "29.3" "24.6" "28.0" "25.4" "18.9" "23.9" "22.9" "26.1" "24.4" "160.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2298765926132750268" "False" "Medium" "IsMasterProtein" "Q86XX4" "Extracellular matrix organizing protein FRAS1 OS=Homo sapiens OX=9606 GN=FRAS1 PE=1 SV=2" "0.028" "False" "1.450" "0" "1" "4" "1" "4008" "442.9" "5.57" "7.66" "1" "transport;developmental processes;other biological processes" "extracellular matrix;plasma membrane;other membranes" "extracellular structural activity;other molecular function" "Pf00093, Pf03160, Pf16184" "80144" "ENSG00000138759" "FRAS1" "A2RRR8; hsa:80144; Q86UZ4; Q86XX4; Q8N3U9; Q8NAU7; Q96JW7; Q9H6N9; Q9P228" "Development of ureteric collection system" "" "1" "0" "1.132" "0.996" "1.017" "1.041" "1.106" "0.982" "1.132" "1.051" "0.809" "211.6" "239.5" "210.8" "215.2" "220.2" "234.0" "207.8" "239.5" "222.4" "171.2" "" "" "" "" "" "" "" "" "" "" "126.6" "124.5" "116.7" "101.0" "102.1" "119.8" "96.6" "107.5" "120.6" "171.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2233856679390389012" "False" "Medium" "IsMasterProtein" "Q8NBZ9" "Putative uncharacterized protein NEXN-AS1 OS=Homo sapiens OX=9606 GN=NEXN-AS1 PE=5 SV=1" "0.028" "False" "1.447" "4" "1" "1" "1" "246" "25.1" "10.68" "0.00" "1" "" "" "" "" "" "" "NEXN-AS1" "Q8NBZ9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1911741891991956456" "False" "Medium" "IsMasterProtein" "Q9NX14" "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFB11 PE=1 SV=1" "0.028" "False" "1.447" "5" "1" "2" "1" "153" "17.3" "5.22" "4.24" "1" "cell organization and biogenesis;other metabolic processes" "other membranes;mitochondrion" "" "Pf10183" "54539" "ENSG00000147123" "NDUFB11" "hsa:54539; Q5JRR3; Q5JRR4; Q6IAB6; Q8WZ96; Q9BXX9; Q9NX14" "Nonalcoholic fatty liver disease" "Complex I biogenesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2427980612750648457" "False" "Medium" "IsMasterProtein" "P21359" "Neurofibromin OS=Homo sapiens OX=9606 GN=NF1 PE=1 SV=2" "0.029" "False" "1.436" "0" "1" "2" "1" "2839" "319.2" "7.39" "5.58" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00616, Pf13716" "4763" "ENSG00000196712" "NF1" "hsa:4763; O00662; P21359; Q14284; Q14930; Q14931; Q9UMK3" "Pilocytic astrocytoma; Glioblastoma signaling pathways; Aryl hydrocarbon receptor pathway; MECP2 and associated Rett syndrome; MAPK signaling pathway; Ras signaling; Transcription co-factors SKI and SKIL protein partners; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Melanoma; EGFR tyrosine kinase inhibitor resistance; NF1 copy number variation syndrome" "Regulation of RAS by GAPs; RAS signaling downstream of NF1 loss-of-function variants" "14" "0" "0.967" "1.064" "1.178" "0.975" "1.003" "0.894" "1.240" "1.079" "0.521" "631.6" "610.8" "671.9" "743.8" "615.8" "633.2" "564.4" "783.3" "681.3" "329.0" "" "" "" "" "" "" "" "" "" "" "378.0" "317.4" "372.1" "349.2" "285.4" "324.2" "262.5" "351.7" "369.7" "329.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7482733620363159602" "False" "Medium" "IsMasterProtein" "Q9BVS5" "tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=TRMT61B PE=1 SV=2" "0.029" "False" "1.435" "1" "1" "1" "1" "477" "52.9" "6.62" "2.50" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf08704" "55006" "ENSG00000171103" "TRMT61B" "hsa:55006; Q9BVS5; Q9H0Q9; Q9NWS7" "" "tRNA modification in the mitochondrion" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3252394429536465777" "False" "Medium" "IsMasterProtein" "Q32P41" "tRNA (guanine(37)-N1)-methyltransferase OS=Homo sapiens OX=9606 GN=TRMT5 PE=1 SV=3" "0.029" "False" "1.432" "2" "1" "1" "1" "509" "58.2" "8.62" "1.88" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf02475" "57570" "ENSG00000126814" "TRMT5" "B2RN19; hsa:57570; Q32P41; Q9P2F4" "" "Synthesis of wybutosine at G37 of tRNA(Phe)" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7542471958177645128" "False" "Medium" "IsMasterProtein" "Q8TBC3" "SH3KBP1-binding protein 1 OS=Homo sapiens OX=9606 GN=SHKBP1 PE=1 SV=2" "0.030" "False" "1.429" "2" "1" "1" "1" "707" "76.3" "8.28" "1.69" "1" "cell organization and biogenesis;other biological processes" "other cytoplasmic organelle" "other molecular function" "Pf02214" "92799" "ENSG00000160410" "SHKBP1" "Q8N2I6; Q8TBC3; Q8WY93; Q96IB8" "" "CDC42 GTPase cycle" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9120451514636770754" "False" "Medium" "IsMasterProtein" "Q12979" "Active breakpoint cluster region-related protein OS=Homo sapiens OX=9606 GN=ABR PE=1 SV=2" "0.030" "False" "1.427" "1" "1" "1" "1" "859" "97.5" "6.55" "0.00" "1" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00168, Pf00620, Pf00621" "29" "ENSG00000159842; ENSG00000276016; ENSG00000278741" "ABR" "B3KW89; B7Z6H7; D3DTH3; D3DTH4; F5H3S2; F5H8B3; hsa:29; Q12979; Q13693; Q13694" "" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC3 GTPase cycle; RHOC GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RAC2 GTPase cycle; RHOB GTPase cycle" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7790719821386758100" "False" "Medium" "IsMasterProtein" "O43520" "Phospholipid-transporting ATPase IC OS=Homo sapiens OX=9606 GN=ATP8B1 PE=1 SV=3" "0.030" "False" "1.421" "1" "1" "1" "1" "1251" "143.6" "7.15" "0.00" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00122, Pf13246, Pf16209, Pf16212" "5205" "ENSG00000081923" "ATP8B1" "hsa:5205; O43520; Q9BTP8" "Complement system in neuronal development and plasticity; Disorders of bile acid synthesis and biliary transport" "Ion transport by P-type ATPases" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4125655909395712746" "False" "Medium" "IsMasterProtein" "Q8IUR7" "Armadillo repeat-containing protein 8 OS=Homo sapiens OX=9606 GN=ARMC8 PE=1 SV=2" "0.030" "False" "1.420" "2" "1" "1" "1" "673" "75.5" "6.73" "0.00" "1" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00514" "25852" "ENSG00000114098" "ARMC8" "A8K0L2; B7Z441; B7Z453; D3DNE6; F5GWK4; hsa:25852; Q6PIL2; Q8IUR7; Q96D19; Q96HZ5; Q9NV02; Q9NV94; Q9Y4R9" "Ciliary landscape" "Neutrophil degranulation" "2" "0" "0.664" "0.892" "1.001" "1.327" "0.808" "1.220" "0.823" "1.020" "1.729" "23.0" "15.2" "20.5" "23.0" "30.5" "18.6" "28.0" "18.9" "23.4" "39.7" "" "" "" "" "" "" "" "" "" "" "13.7" "7.9" "11.4" "10.8" "14.1" "9.5" "13.0" "8.5" "12.7" "39.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2264903312611257722" "False" "Medium" "IsMasterProtein" "Q05469" "Hormone-sensitive lipase OS=Homo sapiens OX=9606 GN=LIPE PE=1 SV=4" "0.030" "False" "1.419" "1" "1" "1" "1" "1076" "116.5" "6.70" "1.68" "1" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf06350, Pf07859" "3991" "ENSG00000079435" "LIPE" "hsa:3991; Q05469; Q3LRT2; Q6NSL7" "AMP-activated protein kinase signaling; Fatty acid beta-oxidation; Adipogenesis; Triacylglyceride synthesis; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Lipid metabolism pathway; Thermogenesis; Insulin signaling; Orexin receptor pathway; Familial partial lipodystrophy" "Triglyceride catabolism" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6137891794897938593" "False" "Medium" "IsMasterProtein" "Q8NEF9" "Serum response factor-binding protein 1 OS=Homo sapiens OX=9606 GN=SRFBP1 PE=1 SV=1" "0.030" "False" "1.417" "2" "1" "1" "1" "429" "48.6" "9.58" "1.62" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf09073" "153443" "ENSG00000151304" "SRFBP1" "hsa:153443; Q5QFI2; Q8NEF9; Q96AH4; Q96DK2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7880299812085229449" "False" "Medium" "IsMasterProtein" "P11049" "Leukocyte antigen CD37 OS=Homo sapiens OX=9606 GN=CD37 PE=1 SV=2" "0.031" "False" "1.413" "3" "1" "2" "1" "281" "31.7" "7.94" "4.56" "1" "" "plasma membrane" "" "Pf00335" "951" "ENSG00000104894" "CD37" "B4DVC1; hsa:951; P11049; Q3KPF9" "TYROBP causal network in microglia" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4016914513787807059" "False" "Medium" "IsMasterProtein" "Q9P2N2" "Rho GTPase-activating protein 28 OS=Homo sapiens OX=9606 GN=ARHGAP28 PE=1 SV=3" "0.032" "False" "1.410" "1" "1" "1" "1" "729" "82.0" "7.75" "1.83" "1" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf00620" "" "ENSG00000088756" "ARHGAP28" "A8MQB7; A8MU88; Q6P160; Q8N4T3; Q9NW53; Q9P2N2" "" "RHOA GTPase cycle" "1" "0" "0.827" "0.850" "0.844" "0.788" "1.014" "0.861" "0.927" "0.847" "0.711" "110.7" "91.6" "94.1" "93.4" "87.3" "112.3" "95.4" "102.6" "93.8" "78.7" "" "" "" "" "" "" "" "" "" "" "66.3" "47.6" "52.1" "43.9" "40.5" "57.5" "44.4" "46.1" "50.9" "78.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5401388015032906251" "False" "Medium" "IsMasterProtein" "O95402" "Mediator of RNA polymerase II transcription subunit 26 OS=Homo sapiens OX=9606 GN=MED26 PE=1 SV=2" "0.032" "False" "1.409" "2" "1" "1" "1" "600" "65.4" "9.16" "0.00" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf08711, Pf15693, Pf15694" "9441" "ENSG00000105085" "MED26" "A1A4S3; hsa:9441; O95402; Q0VGB6" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-946118222351064345" "False" "Medium" "IsMasterProtein" "Q6DD87" "Zinc finger protein 787 OS=Homo sapiens OX=9606 GN=ZNF787 PE=1 SV=4" "0.032" "False" "1.408" "2" "1" "1" "1" "382" "40.4" "7.96" "2.67" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13465, Pf13912" "126208" "ENSG00000142409" "ZNF787" "A0A087WUD1; hsa:126208; O00455; Q6DD87" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2950951748836187489" "False" "Medium" "IsMasterProtein" "Q96MG7" "Non-structural maintenance of chromosomes element 3 homolog OS=Homo sapiens OX=9606 GN=NSMCE3 PE=1 SV=1" "0.032" "False" "1.407" "6" "1" "1" "1" "304" "34.3" "9.28" "0.00" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01454" "56160" "ENSG00000185115; ENSG00000282130" "NSMCE3" "hsa:56160; Q8IW16; Q8TEI6; Q96MG7; Q9H214" "15q11q13 copy number variation" "SUMOylation of DNA damage response and repair proteins" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "High" "High" "High" "High" "Not Found" "Not Found" "High" "High" "1" "" "-8855468257255932724" "False" "Medium" "IsMasterProtein" "Q96MI6" "Protein phosphatase 1M OS=Homo sapiens OX=9606 GN=PPM1M PE=1 SV=2" "0.032" "False" "1.405" "3" "1" "1" "1" "459" "51.1" "5.82" "0.00" "1" "protein metabolism;other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00481" "132160" "ENSG00000164088" "PPM1M" "B7XGB9; F8W976; hsa:132160; Q8N8J9; Q96DB8; Q96MI6" "" "" "0" "0" "0.960" "0.872" "0.969" "0.995" "0.904" "1.151" "0.826" "0.711" "0.801" "107.2" "102.9" "93.5" "103.9" "106.6" "96.9" "123.4" "88.5" "76.2" "85.9" "" "" "" "" "" "" "" "" "" "" "64.1" "53.5" "51.8" "48.8" "49.4" "49.6" "57.4" "39.7" "41.3" "85.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7576893625228470779" "False" "Medium" "IsMasterProtein" "Q9H410" "Kinetochore-associated protein DSN1 homolog OS=Homo sapiens OX=9606 GN=DSN1 PE=1 SV=2" "0.032" "False" "1.403" "4" "1" "1" "1" "356" "40.0" "7.05" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08202" "79980" "ENSG00000149636" "DSN1" "B4DWT2; E1P5U9; hsa:79980; Q5JW55; Q5JW56; Q9H410; Q9H8P4" "" "Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1188171081040075064" "False" "Medium" "IsMasterProtein" "Q92817" "Envoplakin OS=Homo sapiens OX=9606 GN=EVPL PE=1 SV=3" "0.032" "False" "1.402" "0" "1" "1" "1" "2033" "231.5" "6.96" "2.22" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00681, Pf17902, Pf21020" "2125" "ENSG00000167880" "EVPL" "A0AUV5; hsa:2125; Q92817" "" "Formation of the cornified envelope" "1" "0" "1.480" "1.007" "2.332" "1.562" "0.768" "2.209" "1.674" "1.001" "0.674" "52.2" "77.2" "52.5" "121.7" "81.5" "40.1" "115.3" "87.3" "52.2" "35.2" "" "" "" "" "" "" "" "" "" "" "31.2" "40.1" "29.1" "57.1" "37.8" "20.5" "53.6" "39.2" "28.3" "35.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5300611953044969662" "False" "Medium" "IsMasterProtein" "Q9BSJ5" "Mitochondrial nucleoid-associated protein 1 OS=Homo sapiens OX=9606 GN=MTNAP1 PE=1 SV=2" "0.032" "False" "1.402" "2" "1" "2" "1" "609" "67.3" "9.16" "0.00" "1" "" "other membranes" "" "" "55028" "ENSG00000141219" "C17orf80" "A8K9X3; Q5JB45; Q6YAU3; Q9BSJ5; Q9H0L9; Q9H5E6; Q9NWN5" "" "" "0" "0" "0.992" "0.748" "0.484" "0.797" "0.725" "0.687" "0.820" "0.657" "0.535" "37.0" "36.7" "27.7" "17.9" "29.5" "26.9" "25.5" "30.4" "24.3" "19.8" "" "" "" "" "" "" "" "" "" "" "22.2" "19.1" "15.3" "8.4" "13.7" "13.7" "11.8" "13.6" "13.2" "19.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1677605172328813102" "False" "Medium" "IsMasterProtein" "Q6IAA8" "Ragulator complex protein LAMTOR1 OS=Homo sapiens OX=9606 GN=LAMTOR1 PE=1 SV=2" "0.032" "False" "1.401" "15" "1" "1" "1" "161" "17.7" "5.15" "0.00" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15454" "55004" "ENSG00000149357" "LAMTOR1" "hsa:55004; Q6IAA8; Q8WZ09; Q9NWT0" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "Macroautophagy; Regulation of PTEN gene transcription; Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; Amino acids regulate mTORC1; RHOJ GTPase cycle; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Energy dependent regulation of mTOR by LKB1-AMPK; RHOH GTPase cycle" "17" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "-3310116821494939621" "False" "Medium" "IsMasterProtein" "O00584" "Ribonuclease T2 OS=Homo sapiens OX=9606 GN=RNASET2 PE=1 SV=2" "0.032" "False" "1.401" "4" "1" "1" "1" "256" "29.5" "7.08" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;stress response" "non-structural extracellular;mitochondrion;ER/Golgi;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00445" "8635" "ENSG00000026297" "RNASET2" "B2RDA7; E1P5C3; hsa:8635; O00584; Q5T8Q0; Q8TCU2; Q9BZ46; Q9BZ47" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2780012699029809096" "False" "Medium" "IsMasterProtein" "Q9H9J2" "Large ribosomal subunit protein mL44 OS=Homo sapiens OX=9606 GN=MRPL44 PE=1 SV=1" "0.033" "False" "1.399" "2" "1" "1" "1" "332" "37.5" "8.40" "1.71" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;mitochondrion;translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "" "65080" "ENSG00000135900" "MRPL44" "hsa:65080; Q53S16; Q6IA62; Q9H821; Q9H9J2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.025" "1.028" "1.030" "1.191" "1.175" "0.924" "0.950" "1.304" "2.414" "60.4" "61.9" "62.0" "62.2" "71.9" "70.9" "55.8" "57.4" "78.7" "145.7" "" "" "" "" "" "" "" "" "" "" "36.1" "32.2" "34.4" "29.2" "33.3" "36.3" "25.9" "25.8" "42.7" "145.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4549685978582378632" "False" "Medium" "IsMasterProtein" "Q9Y399" "Small ribosomal subunit protein uS2m OS=Homo sapiens OX=9606 GN=MRPS2 PE=1 SV=1" "0.033" "False" "1.398" "6" "1" "1" "1" "296" "33.2" "9.26" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00318" "51116" "ENSG00000122140" "MRPS2" "hsa:51116; Q5T899; Q9BSQ4; Q9Y399" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination; Mitochondrial protein degradation" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2098721597077854322" "False" "Medium" "IsMasterProtein" "Q9NTJ4" "Alpha-mannosidase 2C1 OS=Homo sapiens OX=9606 GN=MAN2C1 PE=1 SV=1" "0.033" "False" "1.398" "1" "1" "2" "1" "1040" "115.8" "6.57" "0.00" "1" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01074, Pf07748, Pf09261, Pf17677" "4123" "ENSG00000140400" "MAN2C1" "H3BMX2; H3BQY8; H3BUT6; hsa:4123; Q13358; Q68EM8; Q9NTJ4; Q9UL64" "" "Lysosomal oligosaccharide catabolism" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3380259188437483549" "False" "Medium" "IsMasterProtein" "Q9NQ88" "Fructose-2,6-bisphosphatase TIGAR OS=Homo sapiens OX=9606 GN=TIGAR PE=1 SV=1" "0.034" "False" "1.394" "3" "1" "2" "1" "270" "30.0" "7.69" "5.03" "1" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00300" "57103" "ENSG00000078237" "TIGAR" "B2R840; hsa:57103; Q9NQ88" "Metabolic reprogramming in colon cancer; p53 transcriptional gene network" "TP53 Regulates Metabolic Genes" "3" "0" "1.213" "1.188" "0.959" "1.408" "1.304" "1.008" "0.621" "1.167" "6.325" "70.1" "85.1" "83.3" "67.3" "98.7" "91.5" "70.7" "43.6" "81.8" "443.6" "" "" "" "" "" "" "" "" "" "" "42.0" "44.2" "46.1" "31.6" "45.8" "46.8" "32.9" "19.6" "44.4" "443.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2035928158488886696" "False" "Medium" "IsMasterProtein" "P05160" "Coagulation factor XIII B chain OS=Homo sapiens OX=9606 GN=F13B PE=1 SV=3" "0.034" "False" "1.392" "2" "1" "1" "1" "661" "75.5" "6.39" "0.00" "1" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;other cell component" "" "Pf00084" "2165" "ENSG00000143278; ENSG00000291998" "F13B" "A8K3E5; hsa:2165; P05160; Q5VYL5" "Androgen receptor network in prostate cancer; Blood clotting cascade; Dengue-2 interactions with complement and coagulation cascades; Steroid biosynthesis; Complement and coagulation cascades" "Common Pathway of Fibrin Clot Formation" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2687201697740038391" "False" "Medium" "IsMasterProtein" "Q9NP92" "Large ribosomal subunit protein mL65 OS=Homo sapiens OX=9606 GN=MRPS30 PE=1 SV=2" "0.035" "False" "1.390" "2" "1" "1" "1" "439" "50.3" "7.97" "2.39" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf07147" "10884" "ENSG00000112996" "MRPS30" "hsa:10884; Q96I91; Q96Q19; Q9H0P8; Q9NP92; Q9NSF9; Q9NZ76" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3746726776146342350" "False" "Medium" "IsMasterProtein" "Q7Z2D5" "Phospholipid phosphatase-related protein type 4 OS=Homo sapiens OX=9606 GN=PLPPR4 PE=1 SV=1" "0.035" "False" "1.388" "2" "1" "1" "1" "763" "82.9" "8.73" "2.03" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf01569" "9890" "ENSG00000117600" "PLPPR4" "E7EPS1; hsa:9890; O75043; Q5T9R9; Q7Z2D5; Q86XQ5; Q8N3F1; Q96MP0" "" "Lysosphingolipid and LPA receptors" "1" "0" "1.068" "1.188" "0.914" "1.008" "1.229" "0.894" "1.126" "1.081" "0.813" "115.4" "123.3" "137.1" "105.5" "116.3" "141.8" "103.2" "130.0" "124.8" "93.8" "" "" "" "" "" "" "" "" "" "" "69.1" "64.1" "75.9" "49.5" "53.9" "72.6" "48.0" "58.4" "67.7" "93.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8682712823667695648" "False" "Medium" "IsMasterProtein" "Q7Z2E3" "Aprataxin OS=Homo sapiens OX=9606 GN=APTX PE=1 SV=2" "0.035" "False" "1.386" "2" "1" "1" "1" "356" "40.7" "9.17" "0.00" "1" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11969, Pf16278, Pf17913" "54840" "ENSG00000137074" "APTX" "A8MTN4; D3DRK9; D3DRL0; hsa:54840; Q0P662; Q5T781; Q5T782; Q5T784; Q6JV81; Q6JV82; Q6JV85; Q7Z2E3; Q7Z2F3; Q7Z336; Q7Z5R5; Q7Z6V7; Q7Z6V8; Q9NXM5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3864201792584752389" "False" "Medium" "IsMasterProtein" "Q03188" "Centromere protein C OS=Homo sapiens OX=9606 GN=CENPC PE=1 SV=2" "0.035" "False" "1.385" "1" "1" "1" "1" "943" "106.8" "9.39" "2.01" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11699, Pf15620, Pf15622" "1060" "ENSG00000145241" "CENPC" "hsa:1060; Q03188; Q6PIR0; Q8IW27; Q9P0M5" "" "Separation of Sister Chromatids; Deposition of new CENPA-containing nucleosomes at the centromere; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2837359330570591993" "False" "Medium" "IsMasterProtein" "Q15022" "Polycomb protein SUZ12 OS=Homo sapiens OX=9606 GN=SUZ12 PE=1 SV=3" "0.035" "False" "1.385" "1" "1" "1" "1" "739" "83.0" "8.81" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf09733" "23512" "ENSG00000178691" "SUZ12" "hsa:23512; Q15022; Q96BD9" "Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma; NF1 copy number variation syndrome" "HCMV Early Events; Oxidative Stress Induced Senescence; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; Defective pyroptosis; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PKMTs methylate histone lysines" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5621842442587442909" "False" "Medium" "IsMasterProtein" "Q6ZNA5" "Ferric-chelate reductase 1 OS=Homo sapiens OX=9606 GN=FRRS1 PE=1 SV=2" "0.036" "False" "1.379" "1" "1" "2" "1" "592" "66.1" "7.47" "4.67" "1" "other biological processes" "other membranes" "other molecular function" "Pf02014, Pf03351" "391059" "ENSG00000156869" "FRRS1" "A6NLN7; hsa:391059; Q6ZNA5" "" "" "0" "0" "1.349" "1.092" "1.388" "1.035" "1.277" "1.166" "1.278" "1.241" "0.877" "106.3" "143.3" "116.0" "147.5" "110.0" "135.7" "123.9" "135.8" "131.9" "93.2" "" "" "" "" "" "" "" "" "" "" "63.6" "74.5" "64.2" "69.3" "51.0" "69.5" "57.6" "60.9" "71.6" "93.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4962531905740651297" "False" "Medium" "IsMasterProtein" "Q99715" "Collagen alpha-1(XII) chain OS=Homo sapiens OX=9606 GN=COL12A1 PE=1 SV=2" "0.036" "False" "1.378" "0" "1" "1" "1" "3063" "332.9" "5.53" "0.00" "1" "cell adhesion;cell organization and biogenesis;developmental processes" "extracellular matrix;ER/Golgi" "extracellular structural activity" "Pf00041, Pf00092, Pf01391" "1303" "ENSG00000111799" "COL12A1" "hsa:1303; O43853; Q15955; Q5VYK1; Q5VYK2; Q71UR3; Q99715; Q99716" "" "Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization" "4" "0" "0.696" "0.919" "0.756" "1.178" "0.902" "0.670" "0.672" "0.689" "0.512" "32.6" "22.7" "30.0" "24.7" "38.4" "29.4" "21.9" "21.9" "22.5" "16.7" "" "" "" "" "" "" "" "" "" "" "19.5" "11.8" "16.6" "11.6" "17.8" "15.1" "10.2" "9.8" "12.2" "16.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4629432555354117988" "False" "Medium" "IsMasterProtein" "P78537" "Biogenesis of lysosome-related organelles complex 1 subunit 1 OS=Homo sapiens OX=9606 GN=BLOC1S1 PE=1 SV=2" "0.037" "False" "1.374" "5" "1" "1" "1" "153" "17.3" "9.33" "2.27" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "" "Pf06320" "2647" "ENSG00000135441" "BLOC1S1" "A1L4Q9; hsa:2647; P78537; Q6NZ45" "Alstrom syndrome" "Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6104193342643375019" "False" "Medium" "IsMasterProtein" "O95714" "E3 ubiquitin-protein ligase HERC2 OS=Homo sapiens OX=9606 GN=HERC2 PE=1 SV=2" "0.037" "False" "1.374" "0" "1" "1" "1" "4834" "526.9" "6.28" "0.00" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00173, Pf00415, Pf00569, Pf00632, Pf03256, Pf06701, Pf11515" "8924" "ENSG00000128731" "HERC2" "hsa:8924; O95714; Q86SV7; Q86SV8; Q86SV9; Q86YY3; Q86YY4; Q86YY5; Q86YY6; Q86YY7; Q86YY8; Q86YY9; Q86YZ0; Q86YZ1" "Prader-Willi and Angelman syndrome" "SUMOylation of DNA damage response and repair proteins; Antigen processing: Ubiquitination & Proteasome degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3447640502128280284" "False" "Medium" "IsMasterProtein" "Q9C098" "Serine/threonine-protein kinase DCLK3 OS=Homo sapiens OX=9606 GN=DCLK3 PE=1 SV=2" "0.037" "False" "1.372" "2" "1" "1" "1" "648" "73.8" "8.84" "0.00" "1" "other metabolic processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "85443" "ENSG00000163673" "DCLK3" "hsa:85443; Q9C098" "" "" "0" "0" "0.951" "0.972" "0.994" "1.147" "1.115" "0.896" "1.543" "1.144" "0.941" "20.0" "19.0" "19.4" "19.9" "22.9" "22.3" "17.9" "30.8" "22.9" "18.8" "" "" "" "" "" "" "" "" "" "" "12.0" "9.9" "10.8" "9.3" "10.6" "11.4" "8.3" "13.8" "12.4" "18.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4123953138095996018" "False" "Medium" "IsMasterProtein" "O95398" "Rap guanine nucleotide exchange factor 3 OS=Homo sapiens OX=9606 GN=RAPGEF3 PE=1 SV=6" "0.037" "False" "1.371" "1" "1" "1" "1" "923" "103.7" "7.56" "2.56" "1" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf00610, Pf00617, Pf00618" "10411" "ENSG00000079337" "RAPGEF3" "A8K2G5; E7EQC8; hsa:10411; O95398; O95634; Q8WVN0" "Corticotropin-releasing hormone signaling pathway; EPAC1 and PKA reduction of retinal inflammation" "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Integrin signaling; Rap1 signalling" "6" "0" "1.107" "0.881" "1.009" "0.804" "1.389" "1.061" "1.713" "0.872" "0.707" "170.9" "189.2" "150.6" "172.4" "137.3" "237.4" "181.2" "292.6" "148.9" "120.8" "" "" "" "" "" "" "" "" "" "" "102.3" "98.3" "83.4" "81.0" "63.6" "121.5" "84.3" "131.4" "80.8" "120.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3452513591771994158" "False" "Medium" "IsMasterProtein" "Q6ICG6" "Uncharacterized protein KIAA0930 OS=Homo sapiens OX=9606 GN=KIAA0930 PE=1 SV=1" "0.037" "False" "1.370" "3" "1" "1" "1" "404" "45.8" "7.94" "0.00" "1" "" "" "" "Pf09741" "23313" "ENSG00000100364" "KIAA0930" "B0QY17; B0QY19; B3KT48; hsa:23313; Q6ICG6; Q6ZVE5; Q7Z6K9; Q8IZ76; Q9Y2E2" "" "" "0" "0" "0.692" "0.804" "1.006" "0.846" "1.109" "0.753" "0.743" "0.830" "1.164" "19.7" "13.6" "15.8" "19.8" "16.6" "21.8" "14.8" "14.6" "16.3" "22.9" "" "" "" "" "" "" "" "" "" "" "11.8" "7.1" "8.8" "9.3" "7.7" "11.2" "6.9" "6.6" "8.9" "22.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8647818692013054076" "False" "Medium" "IsMasterProtein" "Q05516" "Zinc finger and BTB domain-containing protein 16 OS=Homo sapiens OX=9606 GN=ZBTB16 PE=1 SV=2" "0.037" "False" "1.369" "1" "1" "1" "1" "673" "74.2" "6.47" "0.00" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00096, Pf00651, Pf13912" "7704" "ENSG00000109906" "ZBTB16" "hsa:7704; Q05516; Q8TAL4" "Hair follicle development: cytodifferentiation - part 3 of 3; Ectoderm differentiation; Ectoderm differentiation; Wnt/beta-catenin signaling pathway in leukemia; Development and heterogeneity of the ILC family; Acute myeloid leukemia" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7842510788255330312" "False" "Medium" "IsMasterProtein" "O75896" "Tumor suppressor candidate 2 OS=Homo sapiens OX=9606 GN=TUSC2 PE=1 SV=3" "0.037" "False" "1.366" "8" "1" "1" "1" "110" "12.1" "9.69" "0.00" "1" "cell cycle OR cell proliferation;stress response;transport;other biological processes" "mitochondrion" "" "Pf15000" "11334" "ENSG00000114383" "TUSC2" "B2R4Y9; hsa:11334; O75896" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5318017384069718868" "False" "Medium" "IsMasterProtein" "Q9Y5B0" "RNA polymerase II subunit A C-terminal domain phosphatase OS=Homo sapiens OX=9606 GN=CTDP1 PE=1 SV=3" "0.037" "False" "1.363" "1" "1" "1" "1" "961" "104.3" "5.27" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00533, Pf03031, Pf09309" "9150" "ENSG00000060069" "CTDP1" "A8MY97; hsa:9150; Q7Z644; Q96BZ1; Q9Y5B0; Q9Y6F5" "" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8727669707947595879" "False" "Medium" "IsMasterProtein" "Q15058" "Kinesin-like protein KIF14 OS=Homo sapiens OX=9606 GN=KIF14 PE=1 SV=1" "0.037" "False" "1.362" "1" "1" "2" "1" "1648" "186.4" "7.91" "0.00" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf00498, Pf16183" "9928" "ENSG00000118193" "KIF14" "hsa:9928; Q14CI8; Q15058; Q4G0A5; Q5T1W3" "" "RHO GTPases activate CIT; RND2 GTPase cycle; RND1 GTPase cycle" "3" "0" "0.910" "1.014" "1.274" "1.171" "1.223" "0.933" "1.341" "0.942" "0.458" "90.4" "82.3" "91.6" "115.2" "105.9" "110.6" "84.4" "121.2" "85.1" "41.4" "" "" "" "" "" "" "" "" "" "" "54.1" "42.8" "50.7" "54.1" "49.1" "56.6" "39.2" "54.4" "46.2" "41.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5936229442522610236" "False" "Medium" "IsMasterProtein" "Q9H204" "Mediator of RNA polymerase II transcription subunit 28 OS=Homo sapiens OX=9606 GN=MED28 PE=1 SV=1" "0.037" "False" "1.360" "4" "1" "1" "1" "178" "19.5" "5.58" "2.56" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytoskeleton;nucleus" "cytoskeletal activity" "Pf11594" "80306" "ENSG00000118579" "MED28" "hsa:80306; Q9BZJ5; Q9H204" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "3" "0" "1.116" "1.011" "1.076" "1.152" "1.040" "1.399" "1.061" "1.184" "1.680" "154.5" "172.5" "156.3" "166.2" "178.0" "160.7" "216.1" "163.9" "183.0" "259.6" "" "" "" "" "" "" "" "" "" "" "92.5" "89.6" "86.5" "78.0" "82.5" "82.3" "100.5" "73.6" "99.3" "259.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7854793599328837284" "False" "Medium" "IsMasterProtein" "Q8N8Q3" "Endonuclease V OS=Homo sapiens OX=9606 GN=ENDOV PE=1 SV=1" "0.037" "False" "1.359" "3" "1" "1" "1" "282" "30.8" "8.03" "2.34" "1" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04493" "284131" "ENSG00000173818" "ENDOV" "hsa:284131; I3L3S4; Q6P2G2; Q86X99; Q8N8Q3; Q8NAK0" "" "" "0" "0" "1.210" "1.383" "1.202" "1.317" "1.519" "1.388" "1.221" "1.209" "4.587" "84.0" "101.6" "116.1" "100.9" "110.6" "127.6" "116.6" "102.6" "101.5" "385.2" "" "" "" "" "" "" "" "" "" "" "50.3" "52.8" "64.3" "47.4" "51.3" "65.3" "54.2" "46.0" "55.1" "385.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2619952528215347024" "False" "Medium" "IsMasterProtein" "P09326" "CD48 antigen OS=Homo sapiens OX=9606 GN=CD48 PE=1 SV=2" "0.037" "False" "1.359" "3" "1" "1" "1" "243" "27.7" "8.07" "0.00" "1" "stress response" "plasma membrane;other membranes" "" "Pf07686, Pf13895" "962" "ENSG00000117091" "CD48" "hsa:962; P09326; Q5U055; Q8MGR0" "Gastric cancer network 2" "Cell surface interactions at the vascular wall" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6207742459099857160" "False" "Medium" "IsMasterProtein" "Q9UJ41" "Rab5 GDP/GTP exchange factor OS=Homo sapiens OX=9606 GN=RABGEF1 PE=1 SV=3" "0.037" "False" "1.357" "2" "1" "1" "1" "491" "56.9" "7.02" "0.00" "1" "transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01754, Pf02204, Pf18151" "27342" "ENSG00000154710" "RABGEF1" "B4DZM7; hsa:27342; Q3HKR2; Q3HKR3; Q53FG0; Q9UJ41" "16p11.2 distal deletion syndrome" "RAB GEFs exchange GTP for GDP on RABs; TBC/RABGAPs" "3" "0" "1.067" "1.175" "1.248" "1.307" "1.075" "1.188" "0.999" "0.994" "1.491" "18.5" "19.7" "21.7" "23.0" "24.1" "19.9" "21.9" "18.4" "18.4" "27.5" "" "" "" "" "" "" "" "" "" "" "11.1" "10.2" "12.0" "10.8" "11.2" "10.2" "10.2" "8.3" "10.0" "27.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4573891914704923062" "False" "Medium" "IsMasterProtein" "Q9BTE1" "Dynactin subunit 5 OS=Homo sapiens OX=9606 GN=DCTN5 PE=1 SV=1" "0.037" "False" "1.357" "4" "1" "6" "1" "182" "20.1" "8.02" "1.67" "1" "developmental processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf21711" "84516" "ENSG00000166847" "DCTN5" "A8K9X8; H3BN51; H3BQA4; hsa:84516; Q9BTE1" "Vasopressin-regulated water reabsorption" "COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8285089334394207834" "False" "Medium" "IsMasterProtein" "Q12959" "Disks large homolog 1 OS=Homo sapiens OX=9606 GN=DLG1 PE=1 SV=2" "0.037" "False" "1.357" "1" "1" "1" "1" "904" "100.4" "5.76" "1.85" "1" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00018, Pf00595, Pf00625, Pf09058, Pf10600, Pf10608" "1739" "ENSG00000075711" "DLG1" "A5YKK7; B4DGU1; B4DGZ8; B7ZMM0; B9EIQ5; D3DXB8; D3DXB9; E7EWL7; E9PG21; hsa:1739; Q12958; Q12959" "Brain-derived neurotrophic factor (BDNF) signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Disruption of postsynaptic signaling by CNV; 3q29 copy number variation syndrome; Cell lineage map for neuronal differentiation" "Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; NrCAM interactions; Activation of Ca-permeable Kainate Receptor" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5058641913772226661" "False" "Medium" "IsMasterProtein" "Q68CJ6" "Nuclear GTPase SLIP-GC OS=Homo sapiens OX=9606 GN=NUGGC PE=1 SV=3" "0.037" "False" "1.357" "1" "1" "1" "1" "796" "91.1" "8.63" "0.00" "1" "other biological processes" "nucleus" "other molecular function" "Pf00350" "389643" "ENSG00000189233" "NUGGC" "hsa:389643; Q68CJ6; Q6ZP73" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "Not Found" "High" "High" "High" "High" "High" "High" "1" "" "-4219783111601557579" "False" "Medium" "IsMasterProtein" "Q13216" "DNA excision repair protein ERCC-8 OS=Homo sapiens OX=9606 GN=ERCC8 PE=1 SV=1" "0.037" "False" "1.357" "2" "1" "1" "1" "396" "44.0" "6.35" "0.00" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400" "1161" "ENSG00000049167" "ERCC8" "B2RB64; hsa:1161; Q13216; Q6FHX5; Q96GB9" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 10q11.21q11.23 copy number variation syndrome" "Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "9" "0" "0.867" "1.014" "1.080" "1.234" "1.066" "0.805" "1.047" "1.138" "0.689" "54.8" "47.6" "55.6" "59.2" "67.7" "58.5" "44.1" "57.4" "62.4" "37.8" "" "" "" "" "" "" "" "" "" "" "32.8" "24.7" "30.8" "27.8" "31.4" "29.9" "20.5" "25.8" "33.9" "37.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3652671627369165893" "False" "Medium" "IsMasterProtein" "Q9HBM1" "Kinetochore protein Spc25 OS=Homo sapiens OX=9606 GN=SPC25 PE=1 SV=1" "0.037" "False" "1.355" "4" "1" "1" "1" "224" "26.1" "8.00" "1.75" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf08234" "57405" "ENSG00000152253; ENSG00000277909" "SPC25" "A8K4X8; D3DPC0; hsa:57405; Q9HBM1" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.167" "1.114" "0.762" "1.388" "1.269" "0.668" "0.404" "1.199" "8.298" "14.6" "17.0" "16.2" "11.1" "20.2" "18.5" "9.7" "5.9" "17.5" "120.8" "" "" "" "" "" "" "" "" "" "" "8.7" "8.8" "9.0" "5.2" "9.4" "9.5" "4.5" "2.6" "9.5" "120.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6530118680274496318" "False" "Medium" "IsMasterProtein" "Q9UHB7" "AF4/FMR2 family member 4 OS=Homo sapiens OX=9606 GN=AFF4 PE=1 SV=1" "0.037" "False" "1.354" "1" "1" "1" "1" "1163" "127.4" "9.31" "0.00" "1" "stress response;other biological processes" "nucleus;other cell component" "" "Pf05110, Pf18875, Pf18876" "27125" "ENSG00000072364" "AFF4" "B2RP19; B7WPD2; hsa:27125; Q498B2; Q59FB3; Q6P592; Q8TDR1; Q9P0E4; Q9UHB7" "" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4381387929152042020" "False" "Medium" "IsMasterProtein" "Q9ULX3" "RNA-binding protein NOB1 OS=Homo sapiens OX=9606 GN=NOB1 PE=1 SV=1" "0.038" "False" "1.350" "2" "1" "1" "1" "412" "46.6" "7.18" "2.45" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08772, Pf15017, Pf17146" "28987" "ENSG00000141101" "NOB1" "hsa:28987; Q7L6B7; Q7M4M4; Q7Z4B5; Q9NWB0; Q9ULX3" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9014625147701874173" "False" "Medium" "IsMasterProtein" "Q5T160" "Probable arginine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=RARS2 PE=1 SV=1" "0.038" "False" "1.349" "1" "1" "1" "1" "578" "65.5" "8.21" "2.01" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf00750, Pf05746" "57038" "ENSG00000146282" "RARS2" "B2RDT7; hsa:57038; Q5T160; Q96FU5; Q9H8K8" "" "Mitochondrial tRNA aminoacylation" "1" "0" "0.983" "1.092" "1.179" "1.004" "1.068" "0.925" "1.049" "1.019" "1.077" "72.2" "70.9" "78.8" "85.1" "72.4" "77.1" "66.8" "75.7" "73.6" "77.8" "" "" "" "" "" "" "" "" "" "" "43.2" "36.9" "43.6" "40.0" "33.6" "39.5" "31.0" "34.0" "39.9" "77.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6831775040715791940" "False" "Medium" "IsMasterProtein" "Q15043" "Metal cation symporter ZIP14 OS=Homo sapiens OX=9606 GN=SLC39A14 PE=1 SV=3" "0.038" "False" "1.348" "2" "1" "1" "1" "492" "54.2" "5.33" "0.00" "1" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "transporter activity" "Pf02535" "23516" "ENSG00000104635" "SLC39A14" "A6NH98; B4DIW3; B6EU88; D3DSR4; hsa:23516; Q15043; Q6ZME8; Q96BB3" "Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis; Ferroptosis" "Zinc influx into cells by the SLC39 gene family" "5" "0" "1.478" "0.963" "1.043" "1.365" "1.096" "0.845" "1.543" "1.469" "0.271" "25.6" "37.9" "24.7" "26.7" "35.0" "28.1" "21.7" "39.6" "37.7" "6.9" "" "" "" "" "" "" "" "" "" "" "15.3" "19.7" "13.7" "12.5" "16.2" "14.4" "10.1" "17.8" "20.4" "6.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2618679762531220374" "False" "Medium" "IsMasterProtein" "Cont_Q14533" "Keratin, type II cuticular Hb1 OS=Homo sapiens OX=9606 GN=KRT81 PE=1 SV=3" "0.038" "True" "1.346" "3" "1" "1" "1" "505" "54.9" "5.47" "0.00" "1" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "bone, tooth or skin structural activity" "Pf00038, Pf16208" "3887" "ENSG00000205426" "KRT81" "hsa:3887; Q14533; Q14846; Q16274; Q17R48; Q8WU52; Q9BR74" "" "Formation of the cornified envelope" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "255502416772388513" "False" "Medium" "IsMasterProtein" "Q07075" "Glutamyl aminopeptidase OS=Homo sapiens OX=9606 GN=ENPEP PE=1 SV=3" "0.038" "False" "1.343" "1" "1" "1" "1" "957" "109.2" "5.47" "0.00" "1" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "2028" "ENSG00000138792" "ENPEP" "hsa:2028; Q07075; Q504U2" "" "Metabolism of Angiotensinogen to Angiotensins" "1" "0" "1.282" "1.081" "1.331" "1.471" "1.417" "1.365" "1.334" "1.415" "0.925" "51.8" "66.5" "56.0" "69.0" "76.2" "73.5" "70.8" "69.2" "73.4" "48.0" "" "" "" "" "" "" "" "" "" "" "31.0" "34.5" "31.0" "32.4" "35.3" "37.6" "32.9" "31.1" "39.8" "48.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "551510042259004717" "False" "Medium" "IsMasterProtein" "Q70J99" "Protein unc-13 homolog D OS=Homo sapiens OX=9606 GN=UNC13D PE=1 SV=1" "0.038" "False" "1.342" "1" "1" "1" "1" "1090" "123.2" "6.65" "0.00" "1" "stress response;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf06292" "201294" "ENSG00000092929" "UNC13D" "B4DWG9; hsa:201294; Q70J99; Q9H7K5" "Deregulation of Rab and Rab effector genes in bladder cancer" "Neutrophil degranulation" "2" "0" "1.214" "0.952" "1.244" "1.383" "1.118" "1.476" "0.992" "1.065" "0.807" "37.1" "45.0" "35.3" "46.1" "51.3" "41.4" "54.7" "36.8" "39.5" "29.9" "" "" "" "" "" "" "" "" "" "" "22.2" "23.4" "19.5" "21.6" "23.8" "21.2" "25.4" "16.5" "21.4" "29.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3431457210334272148" "False" "Medium" "IsMasterProtein" "Q75QN2" "Integrator complex subunit 8 OS=Homo sapiens OX=9606 GN=INTS8 PE=1 SV=1" "0.038" "False" "1.342" "1" "1" "1" "1" "995" "113.0" "7.05" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "" "55656" "ENSG00000164941" "INTS8" "B2RN92; hsa:55656; Q5RKZ3; Q6P1R5; Q75QN2; Q7Z314; Q9NVS6; Q9NWY7" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2454475807514495149" "False" "Medium" "IsMasterProtein" "P27487" "Dipeptidyl peptidase 4 OS=Homo sapiens OX=9606 GN=DPP4 PE=1 SV=2" "0.039" "False" "1.342" "1" "1" "1" "1" "766" "88.2" "6.04" "0.00" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00326, Pf00930" "1803" "ENSG00000197635" "DPP4" "hsa:1803; P27487; Q53TN1" "Ferroptosis" "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4839778628978400801" "False" "Medium" "IsMasterProtein" "Q86WG5" "Myotubularin-related protein 13 OS=Homo sapiens OX=9606 GN=SBF2 PE=1 SV=1" "0.039" "False" "1.340" "1" "1" "1" "1" "1849" "208.3" "7.06" "0.00" "1" "other metabolic processes;developmental processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf02141, Pf02893, Pf03456, Pf06602, Pf12335" "81846" "ENSG00000133812" "SBF2" "hsa:81846; Q3MJF0; Q68DQ3; Q6P459; Q6PJD1; Q7Z325; Q7Z621; Q86VE2; Q86WG5; Q96FE2; Q9C097" "Intracellular trafficking proteins involved in CMT neuropathy" "RAB GEFs exchange GTP for GDP on RABs; Synthesis of PIPs at the plasma membrane" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4302480931010321759" "False" "Medium" "IsMasterProtein" "Q8N2B8" "Putative uncharacterized protein FLJ33534 OS=Homo sapiens OX=9606 PE=2 SV=1" "0.039" "False" "1.340" "6" "1" "2" "1" "174" "19.1" "11.58" "4.46" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8586835114254671768" "False" "Medium" "IsMasterProtein" "Q49MI3" "Ceramide kinase-like protein OS=Homo sapiens OX=9606 GN=CERKL PE=1 SV=1" "0.039" "False" "1.339" "2" "1" "1" "1" "558" "62.6" "8.27" "0.00" "1" "other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00781, Pf19280" "375298" "ENSG00000188452" "CERKL" "B2RPL2; B4DEY1; hsa:375298; Q49MH9; Q49MI0; Q49MI1; Q49MI2; Q49MI3; Q5DVJ2; Q5DVJ4; Q5DVJ5; Q6UZF6; Q6ZP59" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7565000807875479095" "False" "Medium" "IsMasterProtein" "Q9H7T0" "Cation channel sperm-associated auxiliary subunit beta OS=Homo sapiens OX=9606 GN=CATSPERB PE=1 SV=2" "0.038" "False" "1.337" "1" "1" "1" "1" "1116" "126.8" "7.17" "0.00" "1" "other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "" "Pf15149, Pf21541, Pf21548" "79820" "ENSG00000133962; ENSG00000274338" "CATSPERB" "A0AV51; hsa:79820; Q9H7T0" "" "Sperm Motility And Taxes" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4485661638841027145" "False" "Medium" "IsMasterProtein" "P24043" "Laminin subunit alpha-2 OS=Homo sapiens OX=9606 GN=LAMA2 PE=1 SV=4" "0.039" "False" "1.335" "0" "1" "1" "1" "3122" "343.7" "6.40" "2.51" "1" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00052, Pf00053, Pf00054, Pf00055, Pf02210, Pf06008, Pf06009" "3908" "ENSG00000196569" "LAMA2" "P24043; Q14736; Q5VUM2; Q93022" "Arrhythmogenic right ventricular cardiomyopathy; Alpha 6 beta 4 signaling pathway; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Acute viral myocarditis; Small cell lung cancer; Pleural mesothelioma; Orexin receptor pathway" "ECM proteoglycans; Non-integrin membrane-ECM interactions; Laminin interactions; MET activates PTK2 signaling; EGR2 and SOX10-mediated initiation of Schwann cell myelination" "14" "0" "1.129" "1.087" "1.129" "1.030" "1.174" "1.090" "1.136" "1.017" "0.883" "147.9" "167.0" "160.7" "167.0" "152.4" "173.7" "161.3" "168.0" "150.5" "130.6" "" "" "" "" "" "" "" "" "" "" "88.5" "86.8" "89.0" "78.4" "70.6" "88.9" "75.0" "75.4" "81.7" "130.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2803114814399122734" "False" "Medium" "IsMasterProtein" "Q8NFI3" "Cytosolic endo-beta-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=ENGASE PE=1 SV=1" "0.039" "False" "1.333" "1" "1" "1" "1" "743" "83.9" "6.79" "0.00" "1" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf03644" "64772" "ENSG00000167280" "ENGASE" "hsa:64772; Q659F0; Q8NFI3; Q8TB86; Q9H6U4" "" "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7923817397987579375" "False" "Medium" "IsMasterProtein" "P04198" "N-myc proto-oncogene protein OS=Homo sapiens OX=9606 GN=MYCN PE=1 SV=2" "0.039" "False" "1.332" "2" "1" "3" "1" "464" "49.5" "5.66" "7.31" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf01056" "4613" "ENSG00000134323" "MYCN" "hsa:4613; P04198; Q53XS5; Q6LDT9" "Pathways affected in adenoid cystic carcinoma; Development of ureteric collection system; GDNF signaling" "Signaling by ALK" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2084727974235455938" "False" "Medium" "IsMasterProtein" "P02462" "Collagen alpha-1(IV) chain OS=Homo sapiens OX=9606 GN=COL4A1 PE=1 SV=4" "0.039" "False" "1.331" "1" "1" "1" "1" "1669" "160.5" "8.28" "0.00" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;ER/Golgi" "extracellular structural activity;other molecular function" "Pf01391, Pf01413" "1282" "ENSG00000187498" "COL4A1" "A7E2W4; B1AM70; F5H5K0; P02462; Q1P9S9; Q5VWF6; Q86X41; Q8NF88; Q9NYC5" "Spinal cord injury; miRNA targets in ECM and membrane receptors; Focal adhesion; Overview of nanoparticle effects; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; Small cell lung cancer; Pleural mesothelioma; Macrophage-stimulating protein (MSP) signaling network map" "Collagen degradation; Signaling by PDGF; Integrin cell surface interactions; ECM proteoglycans; NCAM1 interactions; Collagen chain trimerization; Non-integrin membrane-ECM interactions; Laminin interactions; Anchoring fibril formation; Crosslinking of collagen fibrils; Scavenging by Class A Receptors" "24" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1227550599144237947" "False" "Medium" "IsMasterProtein" "Q6SPF0" "Sterile alpha motif domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SAMD1 PE=1 SV=1" "0.039" "False" "1.331" "2" "1" "2" "1" "538" "56.0" "7.58" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "other molecular function" "Pf00536, Pf21524" "90378" "ENSG00000288488" "SAMD1" "hsa:90378; Q6P0R3; Q6PIS7; Q6SPF0; Q96IM4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3231455898363948540" "False" "Medium" "IsMasterProtein" "Q15833" "Syntaxin-binding protein 2 OS=Homo sapiens OX=9606 GN=STXBP2 PE=1 SV=2" "0.039" "False" "1.329" "1" "1" "1" "1" "593" "66.4" "6.55" "0.00" "1" "cell-cell signaling;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00995" "6813" "ENSG00000076944" "STXBP2" "B4E175; E7EQD5; hsa:6813; Q15833; Q9BU65" "Splicing factor NOVA regulated synaptic proteins; Insulin signaling" "Platelet degranulation ; Other interleukin signaling" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3328900627537449382" "False" "Medium" "IsMasterProtein" "Q03111" "Protein ENL OS=Homo sapiens OX=9606 GN=MLLT1 PE=1 SV=2" "0.039" "False" "1.328" "2" "1" "1" "1" "559" "62.0" "8.59" "2.04" "1" "other biological processes" "cytosol;nucleus" "other molecular function" "Pf03366, Pf17793" "4298" "ENSG00000130382" "MLLT1" "hsa:4298; Q03111; Q14768" "" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3254824567455471781" "False" "Medium" "IsMasterProtein" "Q6NSI4" "RPA-related protein RADX OS=Homo sapiens OX=9606 GN=RADX PE=1 SV=2" "0.039" "False" "1.327" "2" "1" "1" "1" "855" "97.5" "8.41" "0.00" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf17659" "55086" "ENSG00000147231" "RADX" "H7BY89; hsa:55086; Q4G0L7; Q5JQS1; Q5JRF9; Q6NSI4; Q6PHY5; Q6PII9; Q6PJU8; Q9H7W5; Q9NWA6" "" "" "0" "0" "1.568" "1.298" "1.905" "1.299" "1.152" "1.719" "1.478" "1.076" "0.586" "21.1" "33.1" "27.4" "40.3" "27.4" "24.3" "36.3" "31.2" "22.7" "12.4" "" "" "" "" "" "" "" "" "" "" "12.6" "17.2" "15.2" "18.9" "12.7" "12.5" "16.9" "14.0" "12.3" "12.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8413974576400389324" "False" "Medium" "IsMasterProtein" "Q9NQT5" "Exosome complex component RRP40 OS=Homo sapiens OX=9606 GN=EXOSC3 PE=1 SV=3" "0.039" "False" "1.327" "3" "1" "2" "1" "275" "29.6" "8.10" "1.87" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf15985, Pf21261, Pf21262" "51010" "ENSG00000107371" "EXOSC3" "A8K0K6; hsa:51010; Q5QP85; Q9NQT5; Q9Y3A8" "" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1636757598255095772" "False" "Medium" "IsMasterProtein" "Q9P2H5" "Ubiquitin carboxyl-terminal hydrolase 35 OS=Homo sapiens OX=9606 GN=USP35 PE=1 SV=3" "0.040" "False" "1.318" "1" "1" "1" "1" "1018" "113.3" "5.57" "0.00" "1" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00443, Pf21246" "57558" "ENSG00000118369" "USP35" "hsa:57558; Q9P2H5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-643190933540835554" "False" "Medium" "IsMasterProtein" "Q05586" "Glutamate receptor ionotropic, NMDA 1 OS=Homo sapiens OX=9606 GN=GRIN1 PE=1 SV=1" "0.040" "False" "1.317" "1" "1" "1" "1" "938" "105.3" "8.88" "0.00" "1" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf00060, Pf00497, Pf01094, Pf10613" "2902" "ENSG00000176884" "GRIN1" "A6NLK7; A6NLR1; C9K0X1; hsa:2902; P35437; Q05586; Q12867; Q12868; Q5VSF3; Q5VSF4; Q5VSF5; Q5VSF6; Q5VSF7; Q5VSF8; Q9UPF8; Q9UPF9" "Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Common pathways underlying drug addiction; MECP2 and associated Rett syndrome; BDNF-TrkB signaling; NO/cGMP/PKG mediated neuroprotection; Splicing factor NOVA regulated synaptic proteins; Phosphodiesterases in neuronal function; Ras signaling; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Vitamin D-sensitive calcium signaling in depression; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Orexin receptor pathway; Alzheimer's disease; 5q35 copy number variation; NRXN1 deletion syndrome; Cell lineage map for neuronal differentiation; Sudden infant death syndrome (SIDS) susceptibility pathways" "Assembly and cell surface presentation of NMDA receptors; EPHB-mediated forward signaling; RAF/MAP kinase cascade; Neurexins and neuroligins; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation" "30" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8781078747776304120" "False" "Medium" "IsMasterProtein" "Q9NY12" "H/ACA ribonucleoprotein complex subunit 1 OS=Homo sapiens OX=9606 GN=GAR1 PE=1 SV=1" "0.040" "False" "1.317" "3" "1" "1" "1" "217" "22.3" "10.92" "1.73" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf04410" "54433" "ENSG00000109534" "GAR1" "hsa:54433; Q5MJQ2; Q9NY12" "" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8385719763609438508" "False" "Medium" "IsMasterProtein" "Q8N1P7" "Beta/gamma crystallin domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CRYBG2 PE=1 SV=2" "0.041" "False" "1.312" "1" "1" "1" "1" "1661" "177.8" "6.05" "0.00" "1" "" "" "other molecular function" "Pf00030, Pf00652" "55057" "ENSG00000176092" "CRYBG2" "B2RNG3; hsa:55057; Q5T137; Q5T150; Q8N1P7" "" "" "0" "0" "0.995" "0.855" "0.956" "0.996" "0.758" "0.932" "0.951" "0.794" "0.434" "95.6" "95.1" "81.7" "91.4" "95.2" "72.4" "89.1" "90.9" "75.9" "41.4" "" "" "" "" "" "" "" "" "" "" "57.2" "49.4" "45.2" "42.9" "44.1" "37.1" "41.4" "40.8" "41.2" "41.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5511373002517738364" "False" "Medium" "IsMasterProtein" "Q9HBM6" "Transcription initiation factor TFIID subunit 9B OS=Homo sapiens OX=9606 GN=TAF9B PE=1 SV=1" "0.041" "False" "1.311" "3" "1" "1" "1" "251" "27.6" "9.55" "1.84" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf02291" "51616" "ENSG00000187325" "TAF9B" "B2RUZ9; hsa:51616; Q9HBM6; Q9Y2S3" "" "Ub-specific processing proteases; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4147874032451066507" "False" "Medium" "IsMasterProtein" "Q15036" "Sorting nexin-17 OS=Homo sapiens OX=9606 GN=SNX17 PE=1 SV=1" "0.041" "False" "1.310" "3" "1" "1" "1" "470" "52.9" "7.46" "0.00" "1" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf18116, Pf21271, Pf21273" "9784" "ENSG00000115234" "SNX17" "B4DQM7; hsa:9784; Q15036; Q53HN7; Q6IAS3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "Not Found" "High" "High" "High" "High" "High" "High" "1" ""