"Proteins Unique Sequence ID" "Checked" "Protein FDR Confidence: Combined" "Master" "Accession" "Description" "Exp. q-value: Combined" "Contaminant" "Sum PEP Score" "Coverage [%]" "# Peptides" "# PSMs" "# Unique Peptides" "# AAs" "MW [kDa]" "calc. pI" "Score Sequest HT: Sequest HT" "# Peptides (by Search Engine): Sequest HT" "Biological Process" "Cellular Component" "Molecular Function" "Pfam IDs" "Entrez Gene ID" "Ensembl Gene ID" "Gene Symbol" "Gene ID" "WikiPathways" "Reactome Pathways" "# Protein Pathway Groups" "# Razor Peptides" "Abundance Ratio: (127N, 37C) / (126, 37C)" "Abundance Ratio: (127C, 37C) / (126, 37C)" "Abundance Ratio: (128N, 37C) / (126, 37C)" "Abundance Ratio: (128C, 37C) / (126, 37C)" "Abundance Ratio: (129N, 37C) / (126, 37C)" "Abundance Ratio: (129C, 37C) / (126, 37C)" "Abundance Ratio: (130N, 37C) / (126, 37C)" "Abundance Ratio: (130C, 37C) / (126, 37C)" "Abundance Ratio: (131, 37C) / (126, 37C)" "Abundances (Grouped): 126, 37C" "Abundances (Grouped): 127N, 37C" "Abundances (Grouped): 127C, 37C" "Abundances (Grouped): 128N, 37C" "Abundances (Grouped): 128C, 37C" "Abundances (Grouped): 129N, 37C" "Abundances (Grouped): 129C, 37C" "Abundances (Grouped): 130N, 37C" "Abundances (Grouped): 130C, 37C" "Abundances (Grouped): 131, 37C" "Abundances (Grouped) CV [%]: 126, 37C" "Abundances (Grouped) CV [%]: 127N, 37C" "Abundances (Grouped) CV [%]: 127C, 37C" "Abundances (Grouped) CV [%]: 128N, 37C" "Abundances (Grouped) CV [%]: 128C, 37C" "Abundances (Grouped) CV [%]: 129N, 37C" "Abundances (Grouped) CV [%]: 129C, 37C" "Abundances (Grouped) CV [%]: 130N, 37C" "Abundances (Grouped) CV [%]: 130C, 37C" "Abundances (Grouped) CV [%]: 131, 37C" "Abundance: F34: 126, Sample, 37C" "Abundance: F34: 127N, Sample, 37C" "Abundance: F34: 127C, Sample, 37C" "Abundance: F34: 128N, Sample, 37C" "Abundance: F34: 128C, Sample, 37C" "Abundance: F34: 129N, Sample, 37C" "Abundance: F34: 129C, Sample, 37C" "Abundance: F34: 130N, Sample, 37C" "Abundance: F34: 130C, Sample, 37C" "Abundance: F34: 131, Sample, 37C" "Abundances Count: F34: 126, Sample, 37C" "Abundances Count: F34: 127N, Sample, 37C" "Abundances Count: F34: 127C, Sample, 37C" "Abundances Count: F34: 128N, Sample, 37C" "Abundances Count: F34: 128C, Sample, 37C" "Abundances Count: F34: 129N, Sample, 37C" "Abundances Count: F34: 129C, Sample, 37C" "Abundances Count: F34: 130N, Sample, 37C" "Abundances Count: F34: 130C, Sample, 37C" "Abundances Count: F34: 131, Sample, 37C" "Found in Sample: [S301] F34: 126, Sample, 37C" "Found in Sample: [S302] F34: 127N, Sample, 37C" "Found in Sample: [S303] F34: 127C, Sample, 37C" "Found in Sample: [S304] F34: 128N, Sample, 37C" "Found in Sample: [S305] F34: 128C, Sample, 37C" "Found in Sample: [S306] F34: 129N, Sample, 37C" "Found in Sample: [S307] F34: 129C, Sample, 37C" "Found in Sample: [S308] F34: 130N, Sample, 37C" "Found in Sample: [S309] F34: 130C, Sample, 37C" "Found in Sample: [S310] F34: 131, Sample, 37C" "# Protein Groups" "Modifications" "5927523368410573672" "False" "High" "IsMasterProtein" "P78527" "DNA-dependent protein kinase catalytic subunit OS=Homo sapiens OX=9606 GN=PRKDC PE=1 SV=3" "0.000" "False" "466.910" "34" "135" "289" "135" "4128" "468.8" "7.12" "875.82" "135" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08163, Pf19704, Pf20502" "5591" "ENSG00000253729" "PRKDC" "hsa:5591; P78527; P78528; Q13327; Q13337; Q14175; Q59H99; Q7Z611; Q96SE6; Q9UME3" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Fas ligand pathway and stress induction of heat shock proteins; Pathways affected in adenoid cystic carcinoma; Non-homologous end joining; Osteoblast differentiation and related diseases; DNA repair pathways, full network; DNA damage response" "E3 ubiquitin ligases ubiquitinate target proteins; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); IRF3-mediated induction of type I IFN" "13" "0" "0.973" "1.004" "0.983" "0.956" "0.953" "0.914" "0.914" "0.942" "0.939" "29632.8" "28828.7" "29738.5" "29130.5" "28335.9" "28246.4" "27073.4" "27095.1" "27902.1" "27827.6" "" "" "" "" "" "" "" "" "" "" "27765.9" "23855.4" "27608.4" "22519.2" "24152.8" "26986.8" "24737.8" "24057.7" "27902.1" "26794.1" "104" "104" "104" "104" "104" "104" "104" "104" "104" "104" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2305783293341844831" "False" "High" "IsMasterProtein" "Q14204" "Cytoplasmic dynein 1 heavy chain 1 OS=Homo sapiens OX=9606 GN=DYNC1H1 PE=1 SV=5" "0.000" "False" "397.246" "26" "119" "195" "119" "4646" "532.1" "6.40" "624.10" "119" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf03028, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf17852, Pf18198, Pf18199" "1778" "ENSG00000197102" "DYNC1H1" "B0I1R0; hsa:1778; Q14204; Q6DKQ7; Q8WU28; Q92814; Q9Y4G5" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption; PAFAH1B1 copy number variation" "Neutrophil degranulation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "24" "0" "0.994" "0.979" "0.986" "0.975" "0.980" "0.914" "0.944" "0.946" "0.961" "21364.5" "21232.5" "20914.1" "21056.9" "20838.0" "20941.9" "19535.8" "20158.4" "20213.9" "20522.1" "" "" "" "" "" "" "" "" "" "" "20018.5" "17569.6" "19416.1" "16277.9" "17761.8" "20008.0" "17850.5" "17898.6" "20213.9" "19759.9" "85" "85" "85" "85" "85" "85" "85" "85" "85" "85" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3910954529377130988" "False" "High" "IsMasterProtein" "Q9UPN3" "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 OS=Homo sapiens OX=9606 GN=MACF1 PE=1 SV=4" "0.000" "False" "341.521" "17" "115" "137" "113" "7388" "837.8" "5.39" "428.85" "115" "cell-cell signaling;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf00681, Pf02187, Pf13499, Pf17902, Pf18373, Pf21019, Pf21020, Pf21097" "23499" "ENSG00000127603" "MACF1" "B1ALC5; E9PJT0; hsa:23499; O75053; Q5VW20; Q8WXY1; Q8WXY2; Q96PK2; Q9H540; Q9UKP0; Q9ULG9; Q9UPN3" "Mesodermal commitment pathway; Mesodermal commitment pathway" "" "2" "1" "0.993" "1.008" "1.068" "1.070" "1.051" "1.138" "1.146" "1.134" "1.082" "15892.3" "15781.0" "16025.0" "16970.8" "17010.7" "16698.9" "18093.2" "18207.1" "18021.3" "17188.1" "" "" "" "" "" "" "" "" "" "" "14891.0" "13058.6" "14877.2" "13119.2" "14499.5" "15954.2" "16532.4" "16166.1" "18021.3" "16549.8" "78" "78" "78" "78" "78" "78" "78" "78" "78" "78" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2962281166201317424" "False" "High" "IsMasterProtein" "P35579" "Myosin-9 OS=Homo sapiens OX=9606 GN=MYH9 PE=1 SV=4" "0.000" "False" "332.056" "46" "90" "190" "79" "1960" "226.4" "5.60" "631.22" "90" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00063, Pf01576, Pf02736" "4627" "ENSG00000100345" "MYH9" "A8K6E4; hsa:4627; O60805; P35579; Q60FE2; Q86T83" "Primary focal segmental glomerulosclerosis (FSGS); VEGFA-VEGFR2 signaling; Nephrotic syndrome; HDAC6 interactions in the central nervous system" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Signaling by ALK fusions and activated point mutants; RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; CD163 mediating an anti-inflammatory response" "17" "7" "1.049" "0.996" "0.975" "0.960" "0.978" "0.860" "0.868" "0.887" "0.933" "20505.2" "21504.9" "20416.7" "19986.3" "19688.9" "20051.1" "17632.1" "17796.3" "18183.4" "19127.2" "" "" "" "" "" "" "" "" "" "" "19213.3" "17795.0" "18954.3" "15450.3" "16782.3" "19157.0" "16111.1" "15801.4" "18183.4" "18416.8" "76" "76" "76" "76" "76" "76" "76" "76" "76" "76" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3650651295291502810" "False" "High" "IsMasterProtein" "O75369" "Filamin-B OS=Homo sapiens OX=9606 GN=FLNB PE=1 SV=2" "0.000" "False" "322.460" "41" "89" "160" "84" "2602" "278.0" "5.73" "531.70" "89" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00630" "2317" "ENSG00000136068" "FLNB" "B2ZZ83; B2ZZ84; B2ZZ85; C9JKE6; C9JMC4; hsa:2317; O75369; Q13706; Q59EC2; Q60FE7; Q6MZJ1; Q8WXS9; Q8WXT0; Q8WXT1; Q8WXT2; Q8WXT3; Q9NRB5; Q9NT26; Q9UEV9" "Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Ebola virus infection in host; NPHP1 deletion syndrome" "ISG15 antiviral mechanism" "6" "4" "1.009" "1.041" "1.026" "1.008" "0.994" "1.006" "1.038" "1.055" "1.009" "15630.5" "15773.7" "16275.2" "16032.9" "15752.0" "15531.5" "15729.9" "16225.3" "16493.0" "15763.6" "" "" "" "" "" "" "" "" "" "" "14645.7" "13052.5" "15109.4" "12394.2" "13426.6" "14838.9" "14372.9" "14406.5" "16493.0" "15178.2" "63" "63" "63" "63" "63" "63" "63" "63" "63" "63" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-66753491464337277" "False" "High" "IsMasterProtein" "Q13813" "Spectrin alpha chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTAN1 PE=1 SV=3" "0.000" "False" "301.605" "36" "85" "135" "85" "2472" "284.4" "5.35" "445.45" "85" "cell organization and biogenesis" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf00435, Pf08726, Pf13499" "6709" "ENSG00000197694" "SPTAN1" "hsa:6709; Q13186; Q13813; Q15324; Q16606; Q59EF1; Q5VXV5; Q5VXV6; Q7Z6M5; Q9P0V0" "Fas ligand pathway and stress induction of heat shock proteins" "RAF/MAP kinase cascade; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOV GTPase cycle; Neutrophil degranulation; RHOU GTPase cycle; Nephrin family interactions; NCAM signaling for neurite out-growth; Caspase-mediated cleavage of cytoskeletal proteins" "12" "0" "0.976" "1.022" "1.150" "1.148" "1.138" "1.390" "1.433" "1.384" "1.176" "12875.2" "12560.9" "13163.2" "14805.7" "14778.2" "14656.8" "17895.2" "18452.5" "17816.1" "15147.4" "" "" "" "" "" "" "" "" "" "" "12064.0" "10394.0" "12220.4" "11445.5" "12596.6" "14003.2" "16351.4" "16384.0" "17816.1" "14584.8" "64" "64" "64" "64" "64" "64" "64" "64" "64" "64" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5950667386624240413" "False" "High" "IsMasterProtein" "Q01082" "Spectrin beta chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTBN1 PE=1 SV=2" "0.000" "False" "282.157" "40" "86" "121" "78" "2364" "274.4" "5.57" "388.41" "86" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00307, Pf00435" "6711" "ENSG00000115306" "SPTBN1" "B2RP63; hsa:6711; O60837; Q01082; Q16057; Q53R99; Q59ER3; Q8IX99" "TGF-beta signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "RHOV GTPase cycle; RHOU GTPase cycle; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; COPI-mediated anterograde transport; Nephrin family interactions; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; Signaling by FLT3 fusion proteins" "12" "7" "0.985" "1.033" "1.113" "1.104" "1.120" "1.290" "1.328" "1.300" "1.141" "10939.9" "10779.7" "11305.5" "12170.8" "12080.9" "12256.9" "14109.6" "14532.8" "14219.1" "12481.0" "" "" "" "" "" "" "" "" "" "" "10250.6" "8920.0" "10495.7" "9408.6" "10297.4" "11710.4" "12892.4" "12903.7" "14219.1" "12017.5" "61" "61" "61" "61" "61" "61" "61" "61" "61" "61" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4615289327887409645" "False" "High" "IsMasterProtein" "Q9Y490" "Talin-1 OS=Homo sapiens OX=9606 GN=TLN1 PE=1 SV=3" "0.000" "False" "261.336" "36" "76" "123" "67" "2541" "269.6" "6.07" "435.46" "76" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00373, Pf01608, Pf08913, Pf09141, Pf16511, Pf21692" "7094" "ENSG00000137076" "TLN1" "A0A1S5UZ07; A6NMY0; hsa:7094; Q86YD0; Q9NZQ2; Q9UHH8; Q9UPX3; Q9Y490" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; TROP2 regulatory signaling" "Platelet degranulation ; Signaling by BRAF and RAF1 fusions; XBP1(S) activates chaperone genes; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins" "18" "8" "0.953" "0.940" "0.928" "0.927" "0.964" "0.894" "0.895" "0.918" "0.931" "12509.3" "11918.1" "11758.2" "11608.8" "11594.7" "12057.1" "11184.2" "11201.6" "11487.6" "11645.2" "" "" "" "" "" "" "" "" "" "" "11721.2" "9862.1" "10916.0" "8974.1" "9883.0" "11519.4" "10219.4" "9945.9" "11487.6" "11212.7" "55" "55" "55" "55" "55" "55" "55" "55" "55" "55" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6252367434931231115" "False" "High" "IsMasterProtein" "P49327" "Fatty acid synthase OS=Homo sapiens OX=9606 GN=FASN PE=1 SV=3" "0.000" "False" "251.170" "31" "66" "183" "65" "2511" "273.3" "6.44" "576.60" "66" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00107, Pf00109, Pf00550, Pf00698, Pf00975, Pf02801, Pf08242, Pf08659, Pf16197, Pf21089, Pf21149" "2194" "ENSG00000169710" "FASN" "hsa:2194; P49327; Q13479; Q16702; Q4LE83; Q6P4U5; Q6SS02; Q969R1; Q96C68; Q96IT0" "AMP-activated protein kinase signaling; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; FOXA2 pathway" "ChREBP activates metabolic gene expression; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Vitamin B5 (pantothenate) metabolism" "18" "0" "0.972" "0.982" "0.967" "0.964" "0.957" "0.911" "0.939" "0.971" "0.961" "15509.4" "15082.3" "15237.3" "14999.9" "14953.7" "14835.0" "14127.6" "14566.5" "15053.7" "14901.0" "" "" "" "" "" "" "" "" "" "" "14532.3" "12480.4" "14145.9" "11595.6" "12746.1" "14173.4" "12908.9" "12933.6" "15053.7" "14347.6" "56" "56" "56" "56" "56" "56" "56" "56" "56" "56" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7449371538365957033" "False" "High" "IsMasterProtein" "P12270" "Nucleoprotein TPR OS=Homo sapiens OX=9606 GN=TPR PE=1 SV=3" "0.000" "False" "245.416" "34" "74" "113" "73" "2363" "267.1" "5.02" "400.80" "74" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf07926" "7175" "ENSG00000047410" "TPR" "hsa:7175; P12270; Q15624; Q15655; Q5SWY0; Q99968" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signaling by ALK fusions and activated point mutants" "29" "1" "0.976" "1.015" "1.000" "1.018" "1.020" "1.055" "1.062" "1.059" "1.025" "13149.7" "12834.4" "13341.7" "13149.0" "13386.0" "13417.3" "13868.8" "13967.2" "13925.3" "13480.9" "" "" "" "" "" "" "" "" "" "" "12321.3" "10620.3" "12386.1" "10164.8" "11409.9" "12819.0" "12672.4" "12401.5" "13925.3" "12980.2" "55" "55" "55" "55" "55" "55" "55" "55" "55" "55" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-823981804521467878" "False" "High" "IsMasterProtein" "P46013" "Proliferation marker protein Ki-67 OS=Homo sapiens OX=9606 GN=MKI67 PE=1 SV=2" "0.000" "False" "231.120" "29" "71" "83" "71" "3256" "358.5" "9.45" "267.68" "71" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00498, Pf08065, Pf15276" "4288" "ENSG00000148773" "MKI67" "hsa:4288; P46013; Q5VWH2" "Primary focal segmental glomerulosclerosis (FSGS)" "" "1" "0" "1.031" "0.995" "1.201" "1.280" "1.178" "1.746" "1.847" "1.705" "1.339" "7943.8" "8190.7" "7903.3" "9543.8" "10169.1" "9359.4" "13866.2" "14673.6" "13543.1" "10638.4" "" "" "" "" "" "" "" "" "" "" "7443.3" "6777.7" "7337.3" "7377.8" "8667.9" "8942.0" "12670.0" "13028.7" "13543.1" "10243.3" "52" "52" "52" "52" "52" "52" "52" "52" "52" "52" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4567547795878987385" "False" "High" "IsMasterProtein" "P21333" "Filamin-A OS=Homo sapiens OX=9606 GN=FLNA PE=1 SV=4" "0.000" "False" "223.727" "29" "64" "101" "59" "2647" "280.6" "6.06" "358.90" "64" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00630" "2316" "ENSG00000196924" "FLNA" "E9KL45; hsa:2316; P21333; Q5HY53; Q5HY55; Q8NF52" "Androgen receptor signaling pathway; Prolactin signaling pathway; Focal adhesion; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; IL-4 signaling pathway; Ebola virus infection in host; Joubert syndrome; NPHP1 deletion syndrome" "OAS antiviral response; Platelet degranulation ; RHO GTPases activate PAKs; GP1b-IX-V activation signalling; Cell-extracellular matrix interactions" "14" "0" "0.959" "1.007" "1.022" "0.996" "1.018" "1.001" "1.018" "1.022" "1.010" "9501.2" "9108.9" "9566.4" "9709.1" "9466.7" "9672.7" "9515.1" "9669.2" "9711.5" "9599.7" "" "" "" "" "" "" "" "" "" "" "8902.6" "7537.5" "8881.2" "7505.6" "8069.2" "9241.3" "8694.2" "8585.2" "9711.5" "9243.2" "43" "43" "43" "43" "43" "43" "43" "43" "43" "43" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6210925912035566058" "False" "High" "IsMasterProtein" "Q14980" "Nuclear mitotic apparatus protein 1 OS=Homo sapiens OX=9606 GN=NUMA1 PE=1 SV=2" "0.000" "False" "209.265" "31" "63" "94" "63" "2115" "238.1" "5.78" "328.34" "63" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf21670" "4926" "ENSG00000137497" "NUMA1" "H0YH75; hsa:4926; Q14980; Q14981; Q9BTE9" "Ectoderm differentiation; Ectoderm differentiation; 8p23.1 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Mitotic Prophase" "5" "0" "0.973" "0.958" "1.054" "1.035" "0.977" "1.325" "1.335" "1.256" "1.106" "10957.4" "10666.2" "10501.5" "11552.6" "11343.3" "10704.0" "14515.1" "14627.2" "13759.6" "12119.5" "" "" "" "" "" "" "" "" "" "" "10267.1" "8826.2" "9749.3" "8930.7" "9668.7" "10226.6" "13262.9" "12987.5" "13759.6" "11669.4" "49" "49" "49" "49" "49" "49" "49" "49" "49" "49" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5866289401045489846" "False" "High" "IsMasterProtein" "Q92616" "Stalled ribosome sensor GCN1 OS=Homo sapiens OX=9606 GN=GCN1 PE=1 SV=7" "0.000" "False" "199.724" "25" "64" "95" "64" "2671" "292.5" "7.43" "302.12" "64" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function" "" "10985" "ENSG00000089154" "GCN1" "A8KAY1; hsa:10985; O95001; O95651; Q6P2S3; Q86X65; Q8N5I5; Q8WU80; Q92616; Q99736; Q9UE60" "" "Response of EIF2AK4 (GCN2) to amino acid deficiency" "1" "0" "0.991" "0.995" "0.994" "1.006" "0.993" "0.934" "0.927" "0.913" "0.974" "8122.0" "8046.4" "8081.5" "8074.2" "8169.0" "8063.6" "7588.0" "7527.7" "7411.6" "7909.9" "" "" "" "" "" "" "" "" "" "" "7610.3" "6658.3" "7502.7" "6241.7" "6963.0" "7704.0" "6933.4" "6683.9" "7411.6" "7616.1" "42" "42" "42" "42" "42" "42" "42" "42" "42" "42" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2220837361715177214" "False" "High" "IsMasterProtein" "P08238" "Heat shock protein HSP 90-beta OS=Homo sapiens OX=9606 GN=HSP90AB1 PE=1 SV=4" "0.000" "False" "190.756" "52" "39" "228" "22" "724" "83.2" "5.03" "728.87" "39" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "3326" "ENSG00000096384" "HSP90AB1" "B2R5P0; hsa:3326; P08238; Q5T9W7; Q9NQW0; Q9NTK6" "Nuclear receptors meta-pathway; NRF2 pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; Potential therapeutics for SARS; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Aryl hydrocarbon receptor signalling; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; DDX58/IFIH1-mediated induction of interferon-alpha/beta; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; RHOBTB2 GTPase cycle; Chaperone Mediated Autophagy; HSF1 activation; Attenuation phase; Uptake and function of diphtheria toxin; Assembly and release of respiratory syncytial virus (RSV) virions; Respiratory syncytial virus genome replication" "25" "1" "1.034" "1.041" "1.015" "0.994" "1.029" "0.967" "1.001" "1.027" "1.004" "8226.7" "8507.6" "8562.8" "8353.7" "8179.7" "8466.3" "7955.3" "8232.9" "8450.6" "8259.4" "" "" "" "" "" "" "" "" "" "" "7708.4" "7039.9" "7949.5" "6457.8" "6972.2" "8088.8" "7269.0" "7310.0" "8450.6" "7952.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8201100139023696608" "False" "High" "IsMasterProtein" "Q02952" "A-kinase anchor protein 12 OS=Homo sapiens OX=9606 GN=AKAP12 PE=1 SV=4" "0.000" "False" "183.088" "37" "52" "80" "52" "1782" "191.4" "4.41" "304.11" "52" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf03832, Pf10522" "9590" "ENSG00000131016" "AKAP12" "hsa:9590; O00310; O00498; Q02952; Q4LE68; Q5SZ80; Q5TGN1; Q68D82; Q99970" "G protein signaling pathways" "RHOD GTPase cycle; RHOF GTPase cycle" "3" "0" "1.058" "0.974" "0.944" "0.989" "1.017" "1.057" "1.074" "1.046" "1.010" "12434.5" "13160.5" "12112.1" "11743.1" "12301.7" "12644.3" "13143.8" "13357.4" "13008.6" "12562.8" "" "" "" "" "" "" "" "" "" "" "11651.1" "10890.2" "11244.6" "9077.9" "10485.6" "12080.4" "12010.0" "11860.1" "13008.6" "12096.2" "39" "39" "39" "39" "39" "39" "39" "39" "39" "39" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7065009906831580898" "False" "High" "IsMasterProtein" "P07900" "Heat shock protein HSP 90-alpha OS=Homo sapiens OX=9606 GN=HSP90AA1 PE=1 SV=5" "0.000" "False" "179.684" "50" "41" "221" "24" "732" "84.6" "5.02" "671.03" "41" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "3320" "ENSG00000080824" "HSP90AA1" "A8K500; B3KPJ9; hsa:3320; P07900; Q2PP14; Q5CAQ6; Q5CAQ7; Q9BVQ5" "Nucleotide-binding oligomerization domain (NOD) pathway; TNF-alpha signaling pathway; Corticotropin-releasing hormone signaling pathway; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Aryl hydrocarbon receptor pathway; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced AP-1 survival signaling; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Th17 cell differentiation pathway; HDAC6 interactions in the central nervous system" "Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; Potential therapeutics for SARS; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; vRNP Assembly; Estrogen-dependent gene expression; Regulation of necroptotic cell death; Interleukin-4 and Interleukin-13 signaling; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Sema3A PAK dependent Axon repulsion; DDX58/IFIH1-mediated induction of interferon-alpha/beta; PIWI-interacting RNA (piRNA) biogenesis; VEGFR2 mediated vascular permeability; RHOBTB2 GTPase cycle; Chaperone Mediated Autophagy; HSF1 activation; Attenuation phase; eNOS activation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Uptake and function of diphtheria toxin; Constitutive Signaling by Overexpressed ERBB2; Assembly and release of respiratory syncytial virus (RSV) virions; Respiratory syncytial virus genome replication; Scavenging by Class F Receptors; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "71" "16" "1.022" "0.994" "1.012" "1.015" "1.002" "0.973" "1.027" "1.070" "1.023" "19023.4" "19442.7" "18910.4" "19252.4" "19317.0" "19060.4" "18502.8" "19535.0" "20351.3" "19462.9" "" "" "" "" "" "" "" "" "" "" "17824.9" "16088.6" "17555.9" "14883.0" "16465.3" "18210.4" "16906.6" "17345.2" "20351.3" "18740.1" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6514754949609892250" "False" "High" "IsMasterProtein" "Q9UQE7" "Structural maintenance of chromosomes protein 3 OS=Homo sapiens OX=9606 GN=SMC3 PE=1 SV=2" "0.000" "False" "177.688" "43" "50" "79" "50" "1217" "141.5" "7.18" "267.19" "50" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "9126" "ENSG00000108055" "SMC3" "A8K156; hsa:9126; O60464; Q5T482; Q9UQE7" "Cell cycle; Retinoblastoma gene in cancer; MECP2 and associated Rett syndrome; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins; Meiotic synapsis; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "15" "0" "1.000" "1.025" "0.980" "0.986" "0.987" "0.995" "1.009" "1.017" "0.996" "9068.1" "9071.2" "9295.6" "8886.8" "8943.8" "8945.7" "9025.1" "9151.1" "9222.5" "9035.4" "" "" "" "" "" "" "" "" "" "" "8496.8" "7506.3" "8629.8" "6869.9" "7623.5" "8546.8" "8246.5" "8125.3" "9222.5" "8699.8" "39" "39" "39" "39" "39" "39" "39" "39" "39" "39" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8277375164580502172" "False" "High" "IsMasterProtein" "Q14683" "Structural maintenance of chromosomes protein 1A OS=Homo sapiens OX=9606 GN=SMC1A PE=1 SV=2" "0.000" "False" "171.689" "40" "54" "87" "54" "1233" "143.1" "7.64" "269.33" "54" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "8243" "ENSG00000072501" "SMC1A" "hsa:8243; O14995; Q14683; Q16351; Q2M228" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Pathways affected in adenoid cystic carcinoma; ATM signaling in development and disease ; mRNA processing; Regulation of sister chromatid separation at the metaphase-anaphase transition; Rett syndrome; CAMKK2 pathway; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation; DNA damage response" "Estrogen-dependent gene expression; Separation of Sister Chromatids; Meiotic synapsis; Resolution of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "22" "0" "0.975" "1.022" "0.955" "0.991" "0.985" "1.000" "1.005" "0.995" "0.982" "12050.7" "11745.5" "12312.6" "11509.4" "11944.6" "11875.3" "12050.9" "12113.9" "11989.0" "11834.9" "" "" "" "" "" "" "" "" "" "" "11291.5" "9719.2" "11430.7" "8897.3" "10181.3" "11345.7" "11011.3" "10755.9" "11989.0" "11395.3" "44" "44" "44" "44" "44" "44" "44" "44" "44" "44" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5594688980084840223" "False" "High" "IsMasterProtein" "Q63HN8" "E3 ubiquitin-protein ligase RNF213 OS=Homo sapiens OX=9606 GN=RNF213 PE=1 SV=3" "0.000" "False" "171.310" "11" "58" "70" "57" "5207" "591.0" "6.48" "209.81" "58" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097, Pf20173" "57674" "ENSG00000173821" "RNF213" "C9JCP4; D6RI12; F8WKS1; hsa:57674; Q63HN8; Q658P6; Q69YK7; Q6MZR1; Q8IWF4; Q8IZX1; Q8IZX2; Q8N406; Q8TEU0; Q9H6C9; Q9H6H9; Q9H6P3; Q9H8A9; Q9HCF4; Q9HCL8" "" "Antigen processing: Ubiquitination & Proteasome degradation; Signaling by ALK fusions and activated point mutants; Suppression of apoptosis" "3" "0" "1.041" "1.002" "1.052" "1.005" "1.004" "0.945" "0.952" "0.968" "1.014" "7625.1" "7935.0" "7643.7" "8020.1" "7666.8" "7652.1" "7202.5" "7259.3" "7380.1" "7733.0" "" "" "" "" "" "" "" "" "" "" "7144.7" "6566.1" "7096.2" "6199.9" "6535.0" "7310.8" "6581.2" "6445.5" "7380.1" "7445.8" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5864065326781896084" "False" "High" "IsMasterProtein" "P27708" "Multifunctional protein CAD OS=Homo sapiens OX=9606 GN=CAD PE=1 SV=3" "0.000" "False" "170.700" "25" "51" "91" "50" "2225" "242.8" "6.46" "287.18" "51" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00117, Pf00185, Pf00988, Pf01979, Pf02142, Pf02729, Pf02786, Pf02787" "790" "ENSG00000084774" "CAD" "D6W552; hsa:790; P27708; Q6P0Q0; Q96CK3" "Endothelin pathways; Amino acid metabolism; Pyrimidine metabolism" "Pyrimidine biosynthesis" "4" "0" "1.006" "1.005" "1.010" "0.988" "0.971" "0.893" "0.883" "0.891" "0.950" "8393.8" "8445.2" "8437.6" "8475.7" "8296.9" "8148.3" "7498.1" "7415.8" "7475.9" "7975.7" "" "" "" "" "" "" "" "" "" "" "7864.9" "6988.3" "7833.3" "6552.1" "7072.0" "7785.0" "6851.2" "6584.5" "7475.9" "7679.5" "40" "40" "40" "40" "40" "40" "40" "40" "40" "40" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8705476780399299386" "False" "High" "IsMasterProtein" "P46940" "Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens OX=9606 GN=IQGAP1 PE=1 SV=1" "0.000" "False" "170.163" "32" "46" "82" "44" "1657" "189.1" "6.48" "252.16" "46" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00307, Pf00612, Pf00616, Pf03836" "8826" "ENSG00000140575" "IQGAP1" "A7MBM3; hsa:8826; P46940" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; Ciliary landscape; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "Signaling by BRAF and RAF1 fusions; RHOV GTPase cycle; Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "25" "2" "0.996" "1.050" "1.001" "0.994" "1.007" "0.944" "0.993" "0.975" "0.982" "7034.3" "7003.7" "7389.4" "7042.6" "6993.4" "7080.6" "6637.8" "6985.8" "6857.8" "6909.1" "" "" "" "" "" "" "" "" "" "" "6591.1" "5795.5" "6860.2" "5444.2" "5961.0" "6764.8" "6065.2" "6202.6" "6857.8" "6652.4" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7834140751544997544" "False" "High" "IsMasterProtein" "Q7Z6Z7" "E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens OX=9606 GN=HUWE1 PE=1 SV=3" "0.000" "False" "166.311" "12" "55" "77" "55" "4374" "481.6" "5.22" "245.65" "55" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00627, Pf00632, Pf02825, Pf06012, Pf06025, Pf14377" "10075" "ENSG00000086758" "HUWE1" "hsa:10075; O15029; Q4G2Z2; Q5H961; Q6P4D0; Q7Z6Z7; Q8NG67; Q9BUI0; Q9HCJ4; Q9NSL6; Q9P0A9" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation" "2" "0" "0.970" "0.977" "0.939" "0.963" "0.956" "0.921" "0.907" "0.905" "0.945" "10832.0" "10504.1" "10587.4" "10176.1" "10428.5" "10350.0" "9978.9" "9829.0" "9806.7" "10240.9" "" "" "" "" "" "" "" "" "" "" "10149.5" "8692.0" "9829.0" "7866.6" "8889.0" "9888.5" "9118.1" "8727.2" "9806.7" "9860.6" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1039523901046503215" "False" "High" "IsMasterProtein" "P42704" "Leucine-rich PPR motif-containing protein, mitochondrial OS=Homo sapiens OX=9606 GN=LRPPRC PE=1 SV=3" "0.000" "False" "161.210" "35" "48" "92" "48" "1394" "157.8" "6.13" "274.13" "48" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf01535" "10128" "ENSG00000138095" "LRPPRC" "A0PJE3; A8K1V1; hsa:10128; P42704; Q53PC0; Q53QN7; Q6ZUD8; Q7Z7A6; Q96D84" "Ciliary landscape" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial RNA degradation" "5" "0" "0.980" "1.030" "0.971" "1.009" "1.030" "0.966" "1.018" "1.025" "1.015" "8661.2" "8483.8" "8919.4" "8413.7" "8739.1" "8919.9" "8369.0" "8820.7" "8874.6" "8791.2" "" "" "" "" "" "" "" "" "" "" "8115.5" "7020.2" "8280.5" "6504.2" "7449.0" "8522.1" "7647.0" "7831.9" "8874.6" "8464.7" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-951770295276680131" "False" "High" "IsMasterProtein" "P09874" "Poly [ADP-ribose] polymerase 1 OS=Homo sapiens OX=9606 GN=PARP1 PE=1 SV=4" "0.000" "False" "157.763" "39" "43" "89" "43" "1014" "113.0" "8.88" "284.87" "43" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf00644, Pf00645, Pf02877, Pf05406, Pf08063, Pf21728" "142" "ENSG00000143799" "PARP1" "B1ANJ4; hsa:142; P09874; Q8IUZ9" "Corticotropin-releasing hormone signaling pathway; Nanoparticle triggered regulated necrosis; Fas ligand pathway and stress induction of heat shock proteins; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Breast cancer pathway; Acute viral myocarditis; Joubert syndrome; Male infertility; Base excision repair; IL-18 signaling pathway; DNA repair pathways, full network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Progeria-associated lipodystrophy; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map" "SUMOylation of DNA damage response and repair proteins; Downregulation of SMAD2/3:SMAD4 transcriptional activity; HDR through MMEJ (alt-NHEJ); Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; vRNA Synthesis; POLB-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER" "25" "0" "1.013" "1.012" "1.019" "1.030" "1.021" "1.139" "1.213" "1.230" "1.093" "11816.2" "11974.9" "11958.3" "12041.2" "12167.1" "12062.0" "13463.2" "14330.0" "14528.6" "12912.4" "" "" "" "" "" "" "" "" "" "" "11071.8" "9909.1" "11101.8" "9308.4" "10370.9" "11524.1" "12301.8" "12723.6" "14528.6" "12432.8" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8891268094734712955" "False" "High" "IsMasterProtein" "Q13428" "Treacle protein OS=Homo sapiens OX=9606 GN=TCOF1 PE=1 SV=3" "0.000" "False" "157.651" "32" "46" "82" "46" "1488" "152.0" "9.04" "255.63" "46" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf03546" "6949" "ENSG00000070814" "TCOF1" "A0JLU0; B4E111; hsa:6949; Q13428; Q6SC72; Q7Z5W9; Q96A52; Q99408; Q99860" "" "" "0" "0" "0.989" "0.973" "0.933" "0.973" "0.932" "0.986" "0.951" "0.926" "0.953" "10140.6" "10024.1" "9865.1" "9463.2" "9869.1" "9447.6" "9999.5" "9643.1" "9386.9" "9663.8" "" "" "" "" "" "" "" "" "" "" "9501.7" "8294.8" "9158.5" "7315.5" "8412.2" "9026.3" "9136.9" "8562.1" "9386.9" "9304.9" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7752798674986433827" "False" "High" "IsMasterProtein" "Q5T4S7" "E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=1" "0.000" "False" "155.660" "10" "51" "66" "51" "5183" "573.5" "6.04" "216.55" "51" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf02207, Pf13764, Pf19423" "23352" "ENSG00000127481" "UBR4" "A8MPT2; A8MQ33; A8MQB1; O60646; O75050; Q4QRK5; Q5T4S7; Q5T4S8; Q5T4S9; Q5TBN8; Q5TBP2; Q6DKH8; Q6P4A4; Q7L8P7; Q8IXJ4; Q8TDN5; Q8WV67; Q9HA46; Q9P2N9; Q9UG82" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation" "2" "0" "0.971" "0.980" "0.984" "0.983" "0.983" "0.947" "0.928" "0.971" "0.986" "7510.2" "7294.1" "7359.0" "7391.0" "7381.6" "7382.4" "7112.3" "6968.1" "7291.5" "7408.0" "" "" "" "" "" "" "" "" "" "" "7037.1" "6035.8" "6831.9" "5713.6" "6291.9" "7053.1" "6498.8" "6187.0" "7291.5" "7132.9" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7303961078788059209" "False" "High" "IsMasterProtein" "P49792" "E3 SUMO-protein ligase RanBP2 OS=Homo sapiens OX=9606 GN=RANBP2 PE=1 SV=2" "0.000" "False" "153.817" "19" "49" "58" "48" "3224" "358.0" "6.20" "198.29" "49" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00160, Pf00638, Pf00641, Pf12185" "5903" "ENSG00000153201" "RANBP2" "hsa:5903; P49792; Q13074; Q15280; Q53TE2; Q59FH7" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; SARS-CoV-2 activates/modulates innate and adaptive immune responses; tRNA processing in the nucleus; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Signaling by ALK fusions and activated point mutants" "35" "1" "1.018" "1.012" "1.037" "1.040" "1.029" "1.110" "1.136" "1.091" "1.069" "8005.5" "8148.9" "8098.6" "8297.7" "8324.3" "8234.2" "8885.5" "9094.5" "8733.4" "8559.7" "" "" "" "" "" "" "" "" "" "" "7501.1" "6743.1" "7518.5" "6414.5" "7095.4" "7867.0" "8119.0" "8075.0" "8733.4" "8241.8" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2015185769260426388" "False" "High" "IsMasterProtein" "P53396" "ATP-citrate synthase OS=Homo sapiens OX=9606 GN=ACLY PE=1 SV=3" "0.000" "False" "146.675" "40" "41" "85" "41" "1101" "120.8" "7.33" "281.02" "41" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00285, Pf00549, Pf02629, Pf16114" "47" "ENSG00000131473" "ACLY" "B4DIM0; B4E3P0; hsa:47; P53396; Q13037; Q9BRL0" "Sterol regulatory element-binding proteins (SREBP) signaling; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Fatty acid biosynthesis; Amino acid metabolism; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer" "Neutrophil degranulation; ChREBP activates metabolic gene expression; Fatty acyl-CoA biosynthesis" "10" "0" "0.921" "0.947" "0.914" "0.900" "0.902" "0.899" "0.897" "0.897" "0.895" "12634.6" "11634.3" "11969.3" "11548.2" "11375.2" "11391.4" "11362.7" "11330.7" "11327.1" "11304.5" "" "" "" "" "" "" "" "" "" "" "11838.6" "9627.2" "11112.0" "8927.3" "9695.9" "10883.4" "10382.5" "10060.6" "11327.1" "10884.7" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1156142612126302656" "False" "High" "IsMasterProtein" "P07814" "Bifunctional glutamate/proline--tRNA ligase OS=Homo sapiens OX=9606 GN=EPRS1 PE=1 SV=5" "0.000" "False" "146.525" "31" "43" "75" "42" "1512" "170.5" "7.33" "251.97" "43" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00458, Pf00587, Pf00749, Pf03129, Pf03950, Pf09180, Pf20974" "2058" "ENSG00000136628" "EPRS1" "A0AVA9; B9EGH3; hsa:2058; P07814; Q05BP6; Q05DF8; Q5DSM1; Q5H9S5; Q6PD57; Q86X73" "Parkinson's disease pathway; VEGFA-VEGFR2 signaling; Amino acid metabolism" "tRNA modification in the nucleus and cytosol; Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "6" "1" "0.974" "0.999" "0.937" "0.961" "0.959" "0.912" "0.959" "1.026" "0.997" "11432.2" "11139.4" "11424.7" "10712.0" "10985.7" "10959.9" "10422.3" "10964.5" "11734.0" "11398.7" "" "" "" "" "" "" "" "" "" "" "10711.9" "9217.7" "10606.4" "8280.9" "9363.9" "10471.2" "9523.2" "9735.4" "11734.0" "10975.4" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "172904709922305924" "False" "High" "IsMasterProtein" "Q5UIP0" "Telomere-associated protein RIF1 OS=Homo sapiens OX=9606 GN=RIF1 PE=1 SV=2" "0.000" "False" "141.012" "20" "46" "54" "46" "2472" "274.3" "5.52" "183.67" "46" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "" "Pf12231" "55183" "ENSG00000080345" "RIF1" "A6NC27; C9JBR1; hsa:55183; Q5H9R3; Q5UIP0; Q5UIP2; Q66YK6; Q6PRU2; Q8TE94; Q99772; Q9H830; Q9H9B9; Q9NVP5; Q9Y4R4" "ATM signaling in development and disease ; 10q11.21q11.23 copy number variation syndrome" "Nonhomologous End-Joining (NHEJ)" "3" "0" "1.028" "1.032" "1.020" "1.047" "1.016" "1.052" "1.073" "1.038" "1.054" "6449.2" "6630.6" "6653.6" "6575.2" "6749.8" "6555.1" "6785.3" "6917.0" "6692.1" "6794.4" "" "" "" "" "" "" "" "" "" "" "6042.9" "5486.8" "6177.0" "5082.9" "5753.3" "6262.8" "6200.0" "6141.6" "6692.1" "6542.0" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7448021442665095265" "False" "High" "IsMasterProtein" "O95347" "Structural maintenance of chromosomes protein 2 OS=Homo sapiens OX=9606 GN=SMC2 PE=1 SV=2" "0.000" "False" "140.232" "32" "43" "56" "43" "1197" "135.6" "8.43" "195.54" "43" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "10592" "ENSG00000136824" "SMC2" "hsa:10592; O95347; Q6IEE0; Q9P1P2" "Retinoblastoma gene in cancer" "Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes" "3" "0" "0.983" "1.004" "0.954" "0.979" "0.956" "0.933" "0.921" "0.927" "0.978" "7269.7" "7144.3" "7298.3" "6933.8" "7118.4" "6950.4" "6784.1" "6694.6" "6739.8" "7107.0" "" "" "" "" "" "" "" "" "" "" "6811.7" "5911.8" "6775.6" "5360.2" "6067.6" "6640.5" "6198.9" "5944.2" "6739.8" "6843.0" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-772083225745130744" "False" "High" "IsMasterProtein" "P11142" "Heat shock cognate 71 kDa protein OS=Homo sapiens OX=9606 GN=HSPA8 PE=1 SV=1" "0.000" "False" "139.319" "54" "34" "178" "21" "646" "70.9" "5.52" "589.39" "34" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00012" "3312" "ENSG00000109971" "HSPA8" "hsa:3312; P11142; Q9H3R6" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Exercise-induced circadian regulation; Measles virus infection; Opioid receptor pathways; Extrafollicular and follicular B cell activation by SARS-CoV-2; 1p36 copy number variation syndrome; HDAC6 interactions in the central nervous system" "AUF1 (hnRNP D0) binds and destabilizes mRNA; Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Late endosomal microautophagy; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Regulation of HSF1-mediated heat shock response; Lysosome Vesicle Biogenesis; Clathrin-mediated endocytosis; mRNA Splicing - Major Pathway; CHL1 interactions; Interleukin-4 and Interleukin-13 signaling; GABA synthesis, release, reuptake and degradation; Lipophagy; Chaperone Mediated Autophagy; Protein methylation; Attenuation phase; Respiratory syncytial virus genome transcription" "27" "12" "1.043" "0.995" "1.031" "0.992" "0.979" "0.980" "1.015" "1.017" "0.995" "14015.3" "14617.6" "13938.6" "14443.1" "13903.5" "13727.3" "13737.7" "14219.8" "14260.5" "13946.4" "" "" "" "" "" "" "" "" "" "" "13132.3" "12095.9" "12940.3" "11165.2" "11851.0" "13115.1" "12552.6" "12625.8" "14260.5" "13428.4" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3757999433169180156" "False" "High" "IsMasterProtein" "Q9NTJ3" "Structural maintenance of chromosomes protein 4 OS=Homo sapiens OX=9606 GN=SMC4 PE=1 SV=2" "0.000" "False" "138.985" "33" "43" "58" "43" "1288" "147.1" "6.79" "174.62" "43" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "10051" "ENSG00000113810" "SMC4" "A6NLT9; D3DNL8; hsa:10051; O95752; Q8NDL4; Q9NTJ3; Q9UNT9" "Ciliary landscape" "Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes" "3" "0" "0.973" "0.971" "0.960" "0.967" "0.964" "0.908" "0.923" "0.905" "0.971" "7916.8" "7705.4" "7689.3" "7601.2" "7655.2" "7633.5" "7184.6" "7309.0" "7166.8" "7684.5" "" "" "" "" "" "" "" "" "" "" "7418.0" "6376.2" "7138.6" "5876.1" "6525.1" "7293.1" "6564.8" "6489.7" "7166.8" "7399.1" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4357852675593899782" "False" "High" "IsMasterProtein" "P25205" "DNA replication licensing factor MCM3 OS=Homo sapiens OX=9606 GN=MCM3 PE=1 SV=3" "0.000" "False" "138.538" "48" "37" "82" "37" "808" "90.9" "5.77" "236.41" "37" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4172" "ENSG00000112118" "MCM3" "B4DWW4; hsa:4172; P25205; Q92660; Q9BTR3; Q9NUE7" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "11" "0" "1.008" "1.033" "0.962" "0.942" "0.917" "0.898" "0.945" "0.968" "0.943" "6853.9" "6908.6" "7078.4" "6590.0" "6457.7" "6283.1" "6157.0" "6479.8" "6637.3" "6464.2" "" "" "" "" "" "" "" "" "" "" "6422.1" "5716.7" "6571.4" "5094.4" "5504.4" "6002.9" "5625.8" "5753.4" "6637.3" "6224.1" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4804495115062908755" "False" "High" "IsMasterProtein" "P41252" "Isoleucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=IARS1 PE=1 SV=2" "0.000" "False" "135.914" "32" "37" "69" "37" "1262" "144.4" "6.15" "209.18" "37" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00133, Pf08264, Pf19302" "3376" "ENSG00000196305; ENSG00000291356" "IARS1" "A8KAE9; hsa:3376; P41252; Q5TCD0; Q7Z3T4; Q9H588" "Amino acid metabolism" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "3" "0" "0.946" "0.995" "0.951" "0.977" "0.970" "0.942" "0.974" "0.972" "0.975" "5257.5" "4975.4" "5232.2" "4998.9" "5138.7" "5101.0" "4950.1" "5121.3" "5107.7" "5127.0" "" "" "" "" "" "" "" "" "" "" "4926.3" "4117.1" "4857.5" "3864.3" "4380.1" "4873.5" "4523.1" "4547.2" "5107.7" "4936.6" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3819136565778515185" "False" "High" "IsMasterProtein" "P13639" "Elongation factor 2 OS=Homo sapiens OX=9606 GN=EEF2 PE=1 SV=4" "0.000" "False" "130.936" "42" "35" "96" "34" "858" "95.3" "6.83" "288.44" "35" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "1938" "ENSG00000167658" "EEF2" "A0A384N6H1; B2RMP5; D6W618; hsa:1938; P13639; Q58J86" "Translation factors; AMP-activated protein kinase signaling; Brain-derived neurotrophic factor (BDNF) signaling pathway; IL-18 signaling pathway" "Neutrophil degranulation; Protein methylation; Uptake and function of diphtheria toxin; Peptide chain elongation; Synthesis of diphthamide-EEF2" "9" "1" "0.998" "1.018" "0.991" "0.997" "1.037" "0.959" "1.007" "1.050" "0.989" "13311.6" "13281.1" "13549.7" "13193.2" "13270.2" "13804.7" "12771.9" "13409.5" "13979.8" "13166.2" "" "" "" "" "" "" "" "" "" "" "12473.0" "10989.9" "12579.2" "10199.0" "11311.1" "13189.1" "11670.1" "11906.3" "13979.8" "12677.2" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "32097797701443302" "False" "High" "IsMasterProtein" "Q14008" "Cytoskeleton-associated protein 5 OS=Homo sapiens OX=9606 GN=CKAP5 PE=1 SV=3" "0.000" "False" "130.729" "20" "42" "68" "42" "2032" "225.4" "7.80" "182.73" "42" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02985, Pf12348, Pf21041" "9793" "ENSG00000175216" "CKAP5" "hsa:9793; Q05D70; Q0VAX7; Q0VAX8; Q14008; Q14668; Q2TA89; Q6NSH4" "4p16.3 copy number variation" "Separation of Sister Chromatids; Regulation of PLK1 Activity at G2/M Transition; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "14" "0" "0.991" "1.025" "0.973" "1.011" "0.996" "0.982" "0.995" "1.017" "1.016" "7031.1" "6967.6" "7209.3" "6841.6" "7106.4" "6999.9" "6904.7" "6995.9" "7152.3" "7140.8" "" "" "" "" "" "" "" "" "" "" "6588.1" "5765.6" "6692.9" "5288.9" "6057.3" "6687.8" "6309.1" "6211.7" "7152.3" "6875.5" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "682895518506643546" "False" "High" "IsMasterProtein" "P11021" "Endoplasmic reticulum chaperone BiP OS=Homo sapiens OX=9606 GN=HSPA5 PE=1 SV=2" "0.000" "False" "130.384" "54" "33" "97" "30" "654" "72.3" "5.16" "343.63" "33" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "translation activity;other molecular function" "Pf00012" "3309" "ENSG00000044574" "HSPA5" "B0QZ61; hsa:3309; P11021; Q2EF78; Q9NPF1; Q9UK02" "Parkin-ubiquitin proteasomal system pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Photodynamic therapy-induced unfolded protein response; Prion disease pathway; Unfolded protein response; Orexin receptor pathway" "Regulation of HSF1-mediated heat shock response; Platelet degranulation ; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ATF6B (ATF6-beta) activates chaperones; IRE1alpha activates chaperones; PERK regulates gene expression; ATF6 (ATF6-alpha) activates chaperone genes" "14" "0" "1.052" "1.011" "1.039" "1.020" "1.037" "0.957" "1.037" "1.053" "1.015" "8204.6" "8627.4" "8292.5" "8527.8" "8368.3" "8504.4" "7853.2" "8507.0" "8636.2" "8324.7" "" "" "" "" "" "" "" "" "" "" "7687.7" "7139.0" "7698.5" "6592.4" "7132.9" "8125.1" "7175.8" "7553.3" "8636.2" "8015.5" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4243510454319930112" "False" "High" "IsMasterProtein" "P33992" "DNA replication licensing factor MCM5 OS=Homo sapiens OX=9606 GN=MCM5 PE=1 SV=5" "0.000" "False" "130.199" "46" "33" "75" "33" "734" "82.2" "8.37" "231.19" "33" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4174" "ENSG00000100297" "MCM5" "hsa:4174; O60785; P33992; Q14578; Q9BTJ4; Q9BWL8" "Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "10" "0" "0.997" "1.008" "1.025" "1.015" "0.992" "1.004" "1.021" "1.036" "1.010" "5964.7" "5948.7" "6012.4" "6114.4" "6056.9" "5917.5" "5989.7" "6091.3" "6179.4" "6023.1" "" "" "" "" "" "" "" "" "" "" "5588.9" "4922.4" "5581.8" "4726.7" "5162.7" "5653.6" "5473.0" "5408.5" "6179.4" "5799.4" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5459324364456559330" "False" "High" "IsMasterProtein" "Q04637" "Eukaryotic translation initiation factor 4 gamma 1 OS=Homo sapiens OX=9606 GN=EIF4G1 PE=1 SV=4" "0.000" "False" "129.302" "26" "45" "104" "39" "1599" "175.4" "5.33" "232.81" "45" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02020, Pf02847, Pf02854" "1981" "ENSG00000114867" "EIF4G1" "D3DNT2; D3DNT4; D3DNT5; E9PFM1; G5E9S1; hsa:1981; O43177; O95066; Q04637; Q5HYG0; Q6ZN21; Q8N102" "Translation factors; VEGFA-VEGFR2 signaling; Acute viral myocarditis; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Pleural mesothelioma" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); AUF1 (hnRNP D0) binds and destabilizes mRNA; ISG15 antiviral mechanism; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "20" "2" "1.018" "1.013" "1.000" "1.015" "1.024" "0.948" "0.965" "0.998" "1.007" "8222.9" "8368.0" "8332.2" "8222.1" "8343.4" "8419.5" "7796.0" "7932.8" "8203.9" "8281.3" "" "" "" "" "" "" "" "" "" "" "7704.9" "6924.4" "7735.4" "6356.1" "7111.7" "8044.0" "7123.4" "7043.6" "8203.9" "7973.7" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4769002131436570839" "False" "High" "IsMasterProtein" "Q00610" "Clathrin heavy chain 1 OS=Homo sapiens OX=9606 GN=CLTC PE=1 SV=5" "0.000" "False" "128.401" "27" "38" "61" "38" "1675" "191.5" "5.69" "202.54" "38" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00637, Pf01394, Pf09268, Pf13838" "1213" "ENSG00000141367" "CLTC" "D3DU00; hsa:1213; Q00610; Q6N0A0; Q86TF2" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; Dengue-2 interactions with complement and coagulation cascades; Ebola virus infection in host; Fragile X syndrome; 7q11.23 copy number variation syndrome; Complement and coagulation cascades" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Recycling pathway of L1; MHC class II antigen presentation; RHOV GTPase cycle; Lysosome Vesicle Biogenesis; RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Entry of Influenza Virion into Host Cell via Endocytosis; Formation of annular gap junctions" "25" "0" "0.995" "1.083" "1.043" "1.085" "1.106" "1.088" "1.125" "1.099" "1.051" "4528.6" "4505.1" "4902.8" "4723.6" "4915.3" "5008.5" "4928.5" "5096.9" "4974.9" "4761.2" "" "" "" "" "" "" "" "" "" "" "4243.3" "3727.9" "4551.7" "3651.6" "4189.7" "4785.1" "4503.3" "4525.5" "4974.9" "4584.4" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6488855965708197639" "False" "High" "IsMasterProtein" "P14618" "Pyruvate kinase PKM OS=Homo sapiens OX=9606 GN=PKM PE=1 SV=4" "0.000" "False" "128.201" "60" "29" "124" "29" "531" "57.9" "7.84" "358.87" "29" "cell organization and biogenesis;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00224, Pf02887" "5315" "ENSG00000067225" "PKM" "A6NFK3; B2R5N8; B3KRY0; B4DFX8; B4DUU6; hsa:5315; P14618; P14786; Q53GK4; Q96E76; Q9BWB5; Q9UCV6; Q9UPF2" "Photodynamic therapy-induced HIF-1 survival signaling; Amino acid metabolism; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Neutrophil degranulation" "10" "0" "0.972" "0.987" "0.983" "0.956" "0.957" "0.946" "0.946" "0.964" "0.963" "8773.4" "8530.5" "8663.4" "8627.5" "8386.3" "8400.4" "8301.6" "8295.4" "8457.9" "8446.6" "" "" "" "" "" "" "" "" "" "" "8220.7" "7058.9" "8042.8" "6669.4" "7148.2" "8025.8" "7585.5" "7365.5" "8457.9" "8132.9" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6880355764133463335" "False" "High" "IsMasterProtein" "P26358" "DNA (cytosine-5)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=DNMT1 PE=1 SV=2" "0.000" "False" "128.075" "25" "37" "60" "37" "1616" "183.1" "7.75" "191.69" "37" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00145, Pf01426, Pf02008, Pf06464, Pf12047" "1786" "ENSG00000130816" "DNMT1" "A0AV63; B7ZLW6; hsa:1786; P26358; Q9UHG5; Q9ULA2; Q9UMZ6" "Trans-sulfuration pathway; One-carbon metabolism; Retinoblastoma gene in cancer; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency; Spina bifida" "SUMOylation of DNA methylation proteins; NoRC negatively regulates rRNA expression; STAT3 nuclear events downstream of ALK signaling; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; Nuclear events stimulated by ALK signaling in cancer" "13" "0" "1.019" "1.029" "1.007" "0.993" "1.001" "0.935" "0.955" "0.966" "0.998" "5907.8" "6020.3" "6076.4" "5948.9" "5865.9" "5915.8" "5523.1" "5642.3" "5705.0" "5895.2" "" "" "" "" "" "" "" "" "" "" "5535.6" "4981.8" "5641.1" "4598.8" "4999.9" "5652.0" "5046.6" "5009.8" "5705.0" "5676.3" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8533826193911874289" "False" "High" "IsMasterProtein" "Q86VP6" "Cullin-associated NEDD8-dissociated protein 1 OS=Homo sapiens OX=9606 GN=CAND1 PE=1 SV=2" "0.000" "False" "128.061" "33" "38" "68" "38" "1230" "136.3" "5.78" "196.29" "38" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf08623, Pf13513" "55832" "ENSG00000111530" "CAND1" "B2RAU3; hsa:55832; O94918; Q6PIY4; Q86VP6; Q8NDJ4; Q96JZ9; Q96T19; Q9BTC4; Q9H0G2; Q9P0H7; Q9UF85" "Endoderm differentiation" "Neutrophil degranulation; Neddylation; Iron uptake and transport" "4" "0" "0.993" "1.008" "1.005" "0.995" "1.001" "0.984" "0.998" "1.011" "0.975" "5740.3" "5702.7" "5786.7" "5771.1" "5714.2" "5746.4" "5647.5" "5726.5" "5802.4" "5597.2" "" "" "" "" "" "" "" "" "" "" "5378.6" "4718.9" "5372.3" "4461.3" "4870.6" "5490.2" "5160.3" "5084.6" "5802.4" "5389.3" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3453697574232543386" "False" "High" "IsMasterProtein" "O43707" "Alpha-actinin-4 OS=Homo sapiens OX=9606 GN=ACTN4 PE=1 SV=2" "0.000" "False" "127.698" "42" "36" "66" "27" "911" "104.8" "5.44" "215.52" "36" "cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00307, Pf00435, Pf08726" "81" "ENSG00000130402; ENSG00000282844" "ACTN4" "A4K467; D6PXK4; hsa:81; O43707; O76048" "Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Striated muscle contraction pathway; Ebola virus infection in host; Nephrotic syndrome; Alstrom syndrome" "Platelet degranulation ; Nephrin family interactions" "9" "6" "1.004" "1.033" "1.063" "1.062" "1.030" "1.052" "1.078" "1.101" "1.036" "4779.7" "4798.4" "4936.8" "5080.0" "5073.8" "4923.7" "5026.0" "5150.8" "5260.4" "4949.6" "" "" "" "" "" "" "" "" "" "" "4478.6" "3970.6" "4583.2" "3927.1" "4324.8" "4704.1" "4592.5" "4573.4" "5260.4" "4765.8" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8293079878251606526" "False" "High" "IsMasterProtein" "P14625" "Endoplasmin OS=Homo sapiens OX=9606 GN=HSP90B1 PE=1 SV=1" "0.000" "False" "127.671" "43" "34" "88" "33" "803" "92.4" "4.84" "294.41" "34" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "7184" "ENSG00000166598" "HSP90B1" "hsa:7184; P14625; Q96A97" "Photodynamic therapy-induced unfolded protein response; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; PI3K-Akt signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Interleukin-4 and Interleukin-13 signaling; Trafficking and processing of endosomal TLR; Scavenging by Class A Receptors; ATF6 (ATF6-alpha) activates chaperone genes" "11" "0" "1.064" "0.995" "1.023" "0.981" "0.975" "0.930" "0.988" "0.995" "0.969" "8996.6" "9573.8" "8954.0" "9206.3" "8827.7" "8771.3" "8364.6" "8885.1" "8951.9" "8719.3" "" "" "" "" "" "" "" "" "" "" "8429.8" "7922.2" "8312.6" "7116.9" "7524.5" "8380.1" "7643.0" "7889.1" "8951.9" "8395.4" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "626595147841982495" "False" "High" "IsMasterProtein" "Q92835" "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 OS=Homo sapiens OX=9606 GN=INPP5D PE=1 SV=2" "0.000" "False" "125.118" "34" "40" "53" "38" "1189" "133.2" "7.59" "170.67" "40" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "other molecular function" "Pf00017" "3635" "ENSG00000168918; ENSG00000281614" "INPP5D" "hsa:3635; O00145; Q13544; Q13545; Q6P5A4; Q92656; Q92835; Q9UE80" "B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; IL-4 signaling pathway; EGF/EGFR signaling pathway; Netrin-UNC5B signaling pathway; 5q35 copy number variation" "Downstream TCR signaling; Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Synthesis of IP3 and IP4 in the cytosol; PECAM1 interactions" "13" "1" "1.020" "1.039" "1.005" "1.024" "1.018" "0.980" "0.999" "1.018" "1.050" "5039.4" "5142.0" "5237.5" "5064.9" "5160.6" "5128.6" "4939.3" "5034.9" "5129.5" "5289.4" "" "" "" "" "" "" "" "" "" "" "4721.9" "4254.9" "4862.3" "3915.4" "4398.8" "4899.9" "4513.2" "4470.5" "5129.5" "5092.9" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2426861074950700078" "False" "High" "IsMasterProtein" "P22314" "Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens OX=9606 GN=UBA1 PE=1 SV=3" "0.000" "False" "124.256" "36" "32" "69" "32" "1058" "117.8" "5.76" "230.41" "32" "protein metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00899, Pf09358, Pf10585, Pf16190, Pf16191" "7317" "ENSG00000130985" "UBA1" "hsa:7317; P22314; Q5JRR8; Q96E13" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "5" "0" "0.994" "0.985" "1.011" "0.981" "0.954" "0.973" "0.972" "0.972" "0.973" "6482.8" "6445.3" "6385.7" "6554.8" "6358.4" "6183.1" "6306.2" "6303.0" "6299.5" "6308.5" "" "" "" "" "" "" "" "" "" "" "6074.4" "5333.4" "5928.3" "5067.1" "5419.8" "5907.4" "5762.1" "5596.4" "6299.5" "6074.2" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6996937188134376608" "False" "High" "IsMasterProtein" "Q16531" "DNA damage-binding protein 1 OS=Homo sapiens OX=9606 GN=DDB1 PE=1 SV=1" "0.000" "False" "123.092" "31" "34" "55" "34" "1140" "126.9" "5.26" "187.09" "34" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "1642" "ENSG00000167986" "DDB1" "A6NG77; B2R648; B4DG00; hsa:1642; O15176; Q13289; Q16531; Q58F96" "Hippo-Merlin signaling dysregulation; Hepatitis B infection; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER; Dual Incision in GG-NER" "14" "0" "0.978" "1.016" "1.002" "0.990" "1.001" "0.973" "1.011" "1.030" "0.993" "6776.8" "6625.7" "6883.7" "6789.8" "6709.6" "6781.4" "6595.5" "6849.2" "6977.1" "6729.4" "" "" "" "" "" "" "" "" "" "" "6349.9" "5482.7" "6390.6" "5248.9" "5719.1" "6479.0" "6026.5" "6081.4" "6977.1" "6479.4" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8215909947984891721" "False" "High" "IsMasterProtein" "P27816" "Microtubule-associated protein 4 OS=Homo sapiens OX=9606 GN=MAP4 PE=1 SV=3" "0.000" "False" "121.090" "35" "39" "63" "39" "1152" "120.9" "5.43" "195.31" "39" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00418" "4134" "ENSG00000047849" "MAP4" "P27816; Q13082; Q59FT2; Q68D74; Q6ZUW9; Q86V26; Q96A76; Q96NS9" "Splicing factor NOVA regulated synaptic proteins; 2q37 copy number variation syndrome" "" "2" "0" "1.022" "1.006" "0.976" "0.987" "0.976" "0.959" "1.013" "1.000" "0.991" "9680.8" "9894.8" "9738.6" "9444.5" "9552.1" "9451.5" "9286.4" "9804.7" "9684.2" "9591.6" "" "" "" "" "" "" "" "" "" "" "9070.9" "8187.9" "9041.1" "7301.0" "8142.0" "9030.0" "8485.3" "8705.6" "9684.2" "9235.4" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-613397371873318473" "False" "High" "IsMasterProtein" "P34932" "Heat shock 70 kDa protein 4 OS=Homo sapiens OX=9606 GN=HSPA4 PE=1 SV=4" "0.000" "False" "120.277" "42" "34" "78" "33" "840" "94.3" "5.19" "249.42" "34" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00012" "3308" "ENSG00000170606" "HSPA4" "hsa:3308; O95756; P34932; Q2TAL4; Q9BUK9" "Parkin-ubiquitin proteasomal system pathway; HDAC6 interactions in the central nervous system" "Regulation of HSF1-mediated heat shock response" "3" "1" "0.958" "0.972" "0.947" "0.923" "0.928" "0.939" "0.949" "0.961" "0.941" "11461.0" "10978.7" "11141.4" "10855.9" "10579.7" "10640.5" "10763.1" "10881.7" "11017.0" "10789.6" "" "" "" "" "" "" "" "" "" "" "10738.9" "9084.7" "10343.4" "8392.1" "9017.8" "10166.0" "9834.6" "9661.9" "11017.0" "10388.9" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4462152622631022902" "False" "High" "IsMasterProtein" "Q92922" "SWI/SNF complex subunit SMARCC1 OS=Homo sapiens OX=9606 GN=SMARCC1 PE=1 SV=3" "0.000" "False" "119.865" "33" "37" "62" "27" "1105" "122.8" "5.76" "193.96" "37" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf04433, Pf16495, Pf16496, Pf16498" "6599" "ENSG00000173473" "SMARCC1" "hsa:6599; Q17RS0; Q6P172; Q8IWH2; Q92922" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "6" "8" "1.120" "1.070" "1.027" "1.032" "1.016" "1.017" "1.039" "1.093" "1.053" "6460.2" "7232.9" "6913.5" "6633.8" "6669.9" "6566.4" "6567.2" "6714.5" "7064.1" "6805.7" "" "" "" "" "" "" "" "" "" "" "6053.2" "5985.1" "6418.3" "5128.2" "5685.2" "6273.6" "6000.6" "5961.8" "7064.1" "6552.9" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3453678624484122586" "False" "High" "IsMasterProtein" "Q8WUM4" "Programmed cell death 6-interacting protein OS=Homo sapiens OX=9606 GN=PDCD6IP PE=1 SV=1" "0.000" "False" "118.935" "38" "36" "63" "36" "868" "96.0" "6.52" "190.25" "36" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf03097, Pf13949" "10015" "ENSG00000170248" "PDCD6IP" "C5MQH7; E9PFU1; hsa:10015; Q6NUS1; Q8WUM4; Q9BX86; Q9NUN0; Q9P2H2; Q9UKL5" "Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells" "Budding and maturation of HIV virion; Regulation of necroptotic cell death; Uptake and function of anthrax toxins" "5" "0" "0.959" "0.984" "0.930" "0.946" "0.958" "0.920" "0.980" "0.950" "0.966" "9734.8" "9332.3" "9575.8" "9056.6" "9209.8" "9330.7" "8952.9" "9540.7" "9249.2" "9407.8" "" "" "" "" "" "" "" "" "" "" "9121.5" "7722.4" "8890.0" "7001.1" "7850.2" "8914.6" "8180.6" "8471.1" "9249.2" "9058.4" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6866488294459179487" "False" "High" "IsMasterProtein" "Q8NFC6" "Biorientation of chromosomes in cell division protein 1-like 1 OS=Homo sapiens OX=9606 GN=BOD1L1 PE=1 SV=2" "0.000" "False" "118.785" "14" "38" "40" "37" "3051" "330.3" "5.08" "135.28" "38" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "" "Pf05205" "259282" "ENSG00000038219" "BOD1L1" "hsa:259282; Q6P0M8; Q8NFC6; Q96AL1; Q9H6G0; Q9NTD6; Q9P2L9" "" "Formation of WDR5-containing histone-modifying complexes" "1" "0" "1.022" "0.974" "0.996" "1.011" "1.038" "1.041" "1.043" "1.028" "1.044" "4281.2" "4375.6" "4171.9" "4266.1" "4330.1" "4443.1" "4455.2" "4463.6" "4399.6" "4471.3" "" "" "" "" "" "" "" "" "" "" "4011.5" "3620.7" "3873.1" "3297.9" "3690.9" "4245.0" "4070.8" "3963.2" "4399.6" "4305.2" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5828511565450602241" "False" "High" "IsMasterProtein" "P46939" "Utrophin OS=Homo sapiens OX=9606 GN=UTRN PE=1 SV=2" "0.000" "False" "118.599" "13" "45" "54" "45" "3433" "394.2" "5.33" "146.31" "45" "cell-cell signaling;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf00569, Pf09068, Pf09069" "7402" "ENSG00000152818" "UTRN" "hsa:7402; P46939; Q5SYY1; Q5SZ57; Q9UJ40" "Primary focal segmental glomerulosclerosis (FSGS)" "EGR2 and SOX10-mediated initiation of Schwann cell myelination" "2" "0" "0.993" "1.024" "1.024" "1.019" "1.045" "1.000" "1.008" "1.019" "1.033" "4028.8" "4002.5" "4126.4" "4127.0" "4106.3" "4211.1" "4028.6" "4059.1" "4103.5" "4161.5" "" "" "" "" "" "" "" "" "" "" "3775.0" "3312.0" "3830.9" "3190.4" "3500.1" "4023.3" "3681.0" "3604.1" "4103.5" "4006.9" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3490068427957957642" "False" "High" "IsMasterProtein" "P49588" "Alanine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=AARS1 PE=1 SV=2" "0.000" "False" "118.251" "37" "31" "57" "31" "968" "106.7" "5.53" "183.21" "31" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01411, Pf02272, Pf07973" "16" "ENSG00000090861" "AARS1" "A6NF14; B4DR45; hsa:16; P49588; Q53GV7; Q96FA0" "IL-18 signaling pathway" "Cytosolic tRNA aminoacylation" "2" "0" "0.953" "0.975" "0.943" "0.959" "0.933" "0.902" "0.939" "0.909" "0.938" "8347.6" "7957.9" "8142.2" "7875.7" "8009.0" "7788.4" "7527.7" "7837.1" "7588.5" "7829.1" "" "" "" "" "" "" "" "" "" "" "7821.7" "6585.1" "7559.0" "6088.3" "6826.7" "7441.0" "6878.3" "6958.6" "7588.5" "7538.3" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5005343800474254733" "False" "High" "IsMasterProtein" "P13796" "Plastin-2 OS=Homo sapiens OX=9606 GN=LCP1 PE=1 SV=6" "0.000" "False" "116.549" "51" "28" "79" "22" "627" "70.2" "5.43" "244.38" "28" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00036, Pf00307" "3936" "ENSG00000136167" "LCP1" "B2R613; B4DUA0; hsa:3936; P13796; Q5TBN4" "" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "1" "4" "1.006" "0.971" "0.957" "0.942" "0.938" "0.929" "0.946" "0.973" "0.939" "8625.6" "8680.2" "8376.0" "8253.5" "8122.9" "8086.7" "8011.0" "8162.3" "8394.8" "8102.7" "" "" "" "" "" "" "" "" "" "" "8082.2" "7182.7" "7776.0" "6380.3" "6923.8" "7726.0" "7320.0" "7247.3" "8394.8" "7801.8" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5619484675981056092" "False" "High" "IsMasterProtein" "P10809" "60 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPD1 PE=1 SV=2" "0.000" "False" "116.342" "54" "25" "96" "25" "573" "61.0" "5.87" "305.36" "25" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00118" "3329" "ENSG00000144381" "HSPD1" "B2R5M6; B7Z712; hsa:3329; P10809; Q38L19; Q9UCR6" "Apoptosis-related network due to altered Notch3 in ovarian cancer; 8p23.1 copy number variation syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways" "Mitochondrial protein degradation; Mitochondrial protein import; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation" "6" "0" "1.004" "0.984" "0.943" "0.996" "0.981" "0.960" "1.009" "1.012" "0.949" "8730.7" "8768.5" "8588.6" "8231.4" "8693.6" "8564.7" "8381.1" "8805.3" "8832.1" "8283.8" "" "" "" "" "" "" "" "" "" "" "8180.6" "7255.8" "7973.4" "6363.2" "7410.2" "8182.7" "7658.1" "7818.2" "8832.1" "7976.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7576515921520274560" "False" "High" "IsMasterProtein" "P13667" "Protein disulfide-isomerase A4 OS=Homo sapiens OX=9606 GN=PDIA4 PE=1 SV=2" "0.000" "False" "116.198" "58" "33" "63" "33" "645" "72.9" "5.07" "199.51" "33" "protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;ER/Golgi;other cell component" "other molecular function" "Pf00085, Pf13848" "9601" "ENSG00000155660" "PDIA4" "A8K4K6; hsa:9601; P13667; Q549T6" "" "" "0" "0" "0.973" "0.989" "0.940" "0.975" "0.955" "0.903" "0.968" "0.981" "0.958" "7648.9" "7445.8" "7562.7" "7193.5" "7457.6" "7304.6" "6905.2" "7404.1" "7507.1" "7327.0" "" "" "" "" "" "" "" "" "" "" "7167.0" "6161.3" "7021.0" "5560.9" "6356.6" "6978.9" "6309.5" "6574.1" "7507.1" "7054.9" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8029242028913948624" "False" "High" "IsMasterProtein" "Q92614" "Unconventional myosin-XVIIIa OS=Homo sapiens OX=9606 GN=MYO18A PE=1 SV=3" "0.000" "False" "115.924" "18" "35" "48" "35" "2054" "233.0" "6.30" "166.25" "35" "cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00063, Pf00595, Pf01576" "399687" "ENSG00000196535" "MYO18A" "hsa:399687; Q5H9U3; Q5QD01; Q5W9F9; Q5W9G1; Q8IXP8; Q92614" "" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by FLT3 fusion proteins" "3" "0" "0.987" "0.980" "1.004" "0.988" "0.987" "0.985" "0.950" "0.963" "0.996" "6691.0" "6606.9" "6555.3" "6719.7" "6610.7" "6601.2" "6593.7" "6359.3" "6442.4" "6666.4" "" "" "" "" "" "" "" "" "" "" "6269.4" "5467.2" "6085.8" "5194.6" "5634.8" "6306.8" "6024.8" "5646.4" "6442.4" "6418.8" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3927890985374291245" "False" "High" "IsMasterProtein" "P11586" "C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=4" "0.000" "False" "115.379" "36" "32" "65" "31" "935" "101.5" "7.30" "212.88" "32" "other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00763, Pf01268, Pf02882" "4522" "ENSG00000100714" "MTHFD1" "A0A024R652; A0A384N5Y3; B2R5Y2; G3V2B8; hsa:4522; P11586; Q86VC9; Q9BVP5" "Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Male infertility; Spina bifida" "Metabolism of folate and pterines" "6" "1" "0.968" "0.986" "0.990" "0.991" "0.950" "0.962" "0.940" "0.931" "0.956" "6248.9" "6047.3" "6158.3" "6183.8" "6195.4" "5935.2" "6012.8" "5873.3" "5818.6" "5970.8" "" "" "" "" "" "" "" "" "" "" "5855.2" "5004.0" "5717.2" "4780.4" "5280.8" "5670.5" "5494.1" "5214.9" "5818.6" "5749.1" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1119286615561917853" "False" "High" "IsMasterProtein" "P00558" "Phosphoglycerate kinase 1 OS=Homo sapiens OX=9606 GN=PGK1 PE=1 SV=3" "0.000" "False" "113.652" "70" "25" "80" "21" "417" "44.6" "8.10" "273.80" "25" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;cytosol" "kinase activity;other molecular function" "Pf00162" "5230" "ENSG00000102144" "PGK1" "A8K4W6; B7Z7A9; hsa:5230; P00558; Q5J7W1; Q6IBT6; Q8NI87" "Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism" "13" "4" "1.007" "0.982" "0.979" "0.981" "0.950" "0.946" "0.975" "0.986" "0.958" "9117.6" "9184.3" "8957.2" "8923.3" "8943.0" "8658.6" "8626.9" "8893.3" "8992.4" "8735.9" "" "" "" "" "" "" "" "" "" "" "8543.2" "7599.9" "8315.6" "6898.1" "7622.8" "8272.5" "7882.7" "7896.4" "8992.4" "8411.4" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7224600777690592247" "False" "High" "IsMasterProtein" "P50991" "T-complex protein 1 subunit delta OS=Homo sapiens OX=9606 GN=CCT4 PE=1 SV=4" "0.000" "False" "112.844" "54" "26" "69" "25" "539" "57.9" "7.83" "229.07" "26" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00118" "10575" "ENSG00000115484" "CCT4" "B2R6I3; B7Z8B1; F5H5W3; hsa:10575; O14870; P50991; Q53QP9; Q96C51" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "7" "1" "0.979" "0.996" "1.001" "0.957" "0.979" "0.955" "0.978" "0.970" "0.945" "6682.0" "6541.6" "6657.0" "6686.5" "6394.6" "6544.4" "6381.7" "6531.9" "6478.8" "6317.4" "" "" "" "" "" "" "" "" "" "" "6261.0" "5413.1" "6180.2" "5169.0" "5450.6" "6252.6" "5831.2" "5799.7" "6478.8" "6082.8" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7054273267636823051" "False" "High" "IsMasterProtein" "Q08211" "ATP-dependent RNA helicase A OS=Homo sapiens OX=9606 GN=DHX9 PE=1 SV=4" "0.000" "False" "112.496" "27" "31" "54" "31" "1270" "140.9" "6.84" "189.61" "31" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00035, Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "1660" "ENSG00000135829" "DHX9" "B2RNV4; hsa:1660; Q05CI5; Q08211; Q12803; Q32Q22; Q5VY62; Q6PD69; Q99556" "MECP2 and associated Rett syndrome; mRNA processing" "mRNA Splicing - Major Pathway; PKR-mediated signaling; RIP-mediated NFkB activation via ZBP1; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "6" "0" "1.075" "1.157" "1.224" "1.193" "1.175" "1.291" "1.321" "1.368" "1.188" "4086.8" "4393.2" "4727.8" "5000.6" "4874.5" "4803.2" "5274.7" "5400.7" "5590.5" "4856.0" "" "" "" "" "" "" "" "" "" "" "3829.3" "3635.3" "4389.2" "3865.7" "4154.9" "4589.0" "4819.6" "4795.2" "5590.5" "4675.6" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8199308046116639924" "False" "High" "IsMasterProtein" "Q29RF7" "Sister chromatid cohesion protein PDS5 homolog A OS=Homo sapiens OX=9606 GN=PDS5A PE=1 SV=1" "0.000" "False" "111.800" "30" "37" "54" "33" "1337" "150.7" "7.91" "175.33" "37" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf20168" "23244" "ENSG00000121892" "PDS5A" "hsa:23244; Q29RF7; Q2TTR5; Q68DF7; Q8N7J4; Q8NG14; Q9Y4D4" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "6" "3" "1.013" "1.024" "1.024" "1.007" "0.996" "0.989" "1.016" "0.994" "1.029" "5409.3" "5480.5" "5536.8" "5538.2" "5444.7" "5385.3" "5349.4" "5495.7" "5375.2" "5564.7" "" "" "" "" "" "" "" "" "" "" "5068.5" "4535.0" "5140.2" "4281.3" "4640.9" "5145.1" "4887.9" "4879.6" "5375.2" "5358.0" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8112712839841425381" "False" "High" "IsMasterProtein" "Q8TAQ2" "SWI/SNF complex subunit SMARCC2 OS=Homo sapiens OX=9606 GN=SMARCC2 PE=1 SV=1" "0.000" "False" "111.712" "28" "34" "60" "24" "1214" "132.8" "5.69" "192.92" "34" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf04433, Pf16495, Pf16496, Pf16498" "6601" "ENSG00000139613" "SMARCC2" "F8VTJ5; hsa:6601; Q59GV3; Q8TAQ2; Q92923; Q96E12; Q96GY4" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome; 10q11.21q11.23 copy number variation syndrome" "RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "7" "0" "1.006" "0.993" "0.980" "1.004" "0.992" "1.029" "1.035" "1.023" "1.014" "5158.5" "5189.3" "5122.8" "5056.1" "5180.4" "5117.7" "5306.8" "5338.3" "5276.8" "5229.7" "" "" "" "" "" "" "" "" "" "" "4833.5" "4294.0" "4755.9" "3908.6" "4415.6" "4889.5" "4849.0" "4739.9" "5276.8" "5035.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-174490317750568225" "False" "High" "IsMasterProtein" "Cont_P60712" "Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1" "0.000" "True" "110.706" "63" "18" "182" "8" "375" "41.7" "5.48" "602.09" "18" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "100011313; 100011351; 100033878; 100078865; 100135470; 100173832; 100303677; 100654618; 100689477; 100919051; 101026869; 101098507; 101375328; 101813373; 101844587; 101941176; 101958638; 102030392; 102041442; 102067189; 102179831; 102286048; 102386754; 102744309; 102772396; 102884469; 103050159; 103077223; 103115297; 103197222; 105077471; 105294565; 105497365; 105551087; 105719490; 105868294; 105990935; 106497948; 107155983; 107515934; 108496585; 108538237; 109314696; 109380220; 109700700; 11461; 280979; 396526; 403580; 414396; 443052; 450133; 574285; 60; 81822" "ENSABRG00000002004; ENSACOG00000001373; ENSACUG00000014525; ENSAMEG00000019137; ENSAMEG00000025519; ENSAMEG00000030859; ENSANAG00000024575; ENSAPLG00020013590; ENSBIXG00000014387; ENSBIXG00005017151; ENSBJAG00000012824; ENSBOBG00000008860; ENSBTAG00000026199; ENSCABG00000005869; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCAFG00805000771; ENSCCEG00000022540; ENSCCNG00000030119; ENSCGRG00001015781; ENSCHIG00000013316; ENSCJAG00000074750; ENSCJAG00000083114; ENSCLAG00000013196; ENSCMUG00000004054; ENSCPBG00000020809; ENSCPGG00000001752; ENSCPOG00000013467; ENSCPRG00005016203; ENSCPVG00000014059; ENSCSRG00000014125; ENSCUSG00005013766; ENSDLEG00000020930; ENSFALG00000013828; ENSFCAG00000006788; ENSFTIG00000005623; ENSG00000075624; ENSGAGG00000004381; ENSGEVG00005007981; ENSGGOG00000001133; ENSJHYG00000006128; ENSJJAG00000018929; ENSLCNG00005020599; ENSMCSG00000014736; ENSMICG00000002791; ENSMLEG00000038914; ENSMMMG00000007553; ENSMMNG00015004465; ENSMMSG00000018023; ENSMMUG00000011153; ENSMNEG00000033949; ENSMODG00000002647; ENSMPUG00000016612; ENSMUGG00000013478; ENSMUNG00000007311; ENSMUSG00000029580; ENSNVIG00000005620; ENSOANG00000007716; ENSOARG00020008714; ENSOSUG00000006211; ENSPANG00000015700; ENSPCEG00000013440; ENSPCLG00000014414; ENSPCTG00005017252; ENSPEMG00000012952; ENSPLOG00000015512; ENSPPYG00000017336; ENSPSTG00000003558; ENSPTEG00000021167; ENSPTRG00000018890; ENSPTXG00000006649; ENSRBIG00000014104; ENSRFEG00010011816; ENSRNOG00000034254; ENSRNOG00055011660; ENSRNOG00060020294; ENSRNOG00065000139; ENSSBOG00000033859; ENSSHAG00000029431; ENSSHBG00005009495; ENSSOCG00000011957; ENSSSCG00000007585; ENSSSCG00005020690; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSUG00005004355; ENSSTOG00000014797; ENSSVLG00005024720; ENSTGEG00000001941; ENSTMTG00000013939; ENSVKKG00000006783; ENSVURG00010018277; ENSZALG00000007655; ENSZLMG00000002642" "Actb; ACTB; Actb_0; ACTL8; LOC101872991; LOC106497948; LOC111145734; LOC112063645; LOC117800408; LOC118142876; PS1TP5BP1" "A0A096NAA6; A0A098M1X5; A0A0B6VJU7; A0A0B8RRU9; A0A0B8RTY2; A0A1D9CFN7; A0A1S2ZVA4; A0A1S3FRD3; A0A1U7Q273; A0A1W7RJQ3; A0A218UWT5; A0A226NJ42; A0A250YGN4; A0A2D4GG12; A0A2J8KJN5; A0A2J8RAH6; A0A2K5CXD5; A0A2K5ZNV7; A0A2K6C9L8; A0A2K6JVX9; A0A2K6UUH3; A0A2P4SFV3; A0A2U3VHD6; A0A2U3XSJ3; A0A2Y9GE45; A0A2Y9JFQ8; A0A2Y9MFS3; A0A2Y9S868; A0A340WEU6; A0A341CY14; A0A384AHN3; A0A3Q7NCZ0; A0A452EGB1; A0A452GTY2; A0A4D9ENE9; A0A4W2DYQ2; A0A4X2LSI7; A0A5E4C6E9; A0A5J5MXV1; A0A5N3VUL9; A0A5N4CXK3; A0A663NBJ0; A0A667IZV1; A0A669QC85; A0A670YBF6; A0A671EW41; A0A672U7D6; A0A673TCM5; A0A674JEF6; A0A6B0SBF2; A0A6B2F1I3; A0A6B2FBI6; A0A6I9HGD1; A0A6J0H3K7; A0A6J0VYA4; A0A6J1Y0U5; A0A6J2ER79; A0A6J2G0V3; A0A6J2MYQ0; A0A6J3AFQ7; A0A6J3DTG2; A0A6J3GBY8; A0A6J3PXY9; A0A6P3QDF4; A0A6P5M7F0; A0A6P5PSI5; A0A6P9D9Q3; A0A7J7X8Z4; A0A7J8FJ79; A0A7J8I7K0; A0A7K4LHI1; A0A7K4PGF5; A0A7K4QS53; A0A7K4T128; A0A7K4TT29; A0A7K4VIP3; A0A7K4WM66; A0A7K4XNG5; A0A7K4Z9S9; A0A7K5AA34; A0A7K5AS89; A0A7K5BQ55; A0A7K5FSS5; A0A7K5H4P8; A0A7K5I2U8; A0A7K5K1W1; A0A7K5L347; A0A7K5MV66; A0A7K5NYG3; A0A7K5PUR4; A0A7K5QKD4; A0A7K5SEW2; A0A7K5SN56; A0A7K5UCA8; A0A7K5V0T3; A0A7K5W0A4; A0A7K5XZZ2; A0A7K5YRX7; A0A7K5ZQ33; A0A7K6AXY2; A0A7K6BYL2; A0A7K6FAZ8; A0A7K6H213; A0A7K6K8T2; A0A7K6M1I6; A0A7K6NUL4; A0A7K6QDF5; A0A7K6RH22; A0A7K6TM80; A0A7K6VD36; A0A7K6W7N1; A0A7K6X5J8; A0A7K6YU38; A0A7K7C2G9; A0A7K7EJS7; A0A7K7FS46; A0A7K7GD18; A0A7K7IBW8; A0A7K7K4W1; A0A7K7KKG3; A0A7K7MQH8; A0A7K7MV68; A0A7K7PD37; A0A7K7QM76; A0A7K7SE36; A0A7K7SKG2; A0A7K7VCN0; A0A7K7W887; A0A7K7XYY4; A0A7K7YKB8; A0A7K8CFW2; A0A7K8EJC7; A0A7K8FS78; A0A7K8G222; A0A7K8IUQ2; A0A7K8JZV4; A0A7K8LPI3; A0A7K8NBM6; A0A7K8PNA5; A0A7K8Q6L8; A0A7K8RIG2; A0A7K8SZY6; A0A7K8UAQ8; A0A7K8VV48; A0A7K8WC57; A0A7K8XP00; A0A7K8YCU6; A0A7K9A6Q1; A0A7K9CAW4; A0A7K9CTY4; A0A7K9E1U2; A0A7K9FBL7; A0A7K9GU20; A0A7K9HIF7; A0A7K9J0P9; A0A7K9JQ87; A0A7K9LVG6; A0A7K9R4T1; A0A7K9RUC2; A0A7K9T1K6; A0A7K9TJU9; A0A7K9VM54; A0A7K9W8F9; A0A7K9XJP5; A0A7K9YTX8; A0A7L0B981; A0A7L0CFC2; A0A7L0DK08; A0A7L0EE55; A0A7L0FB96; A0A7L0GQU8; A0A7L0IUJ7; A0A7L0K254; A0A7L0L680; A0A7L0MVK5; A0A7L0NBG6; A0A7L0Q6H1; A0A7L0RLK8; A0A7L0TBQ4; A0A7L0UF87; A0A7L0WJD4; A0A7L0ZXX6; A0A7L1D3E3; A0A7L1EEL1; A0A7L1EWI9; A0A7L1GDD0; A0A7L1I1H5; A0A7L1IUB6; A0A7L1K0S4; A0A7L1L6I1; A0A7L1MJS1; A0A7L1N7E9; A0A7L1QY43; A0A7L1R9N1; A0A7L1TFJ1; A0A7L1USL1; A0A7L1X2N1; A0A7L1YHH8; A0A7L1ZA36; A0A7L2AFK2; A0A7L2CBA6; A0A7L2DI04; A0A7L2E5K5; A0A7L2ETQ7; A0A7L2GZ90; A0A7L2HLP4; A0A7L2JI84; A0A7L2K9F9; A0A7L2LSR8; A0A7L2MKA1; A0A7L2NWG1; A0A7L2Q5Z6; A0A7L2TKF5; A0A7L2UQP2; A0A7L2WPM1; A0A7L3AB48; A0A7L3AEQ2; A0A7L3CBV1; A0A7L3GBT6; A0A7L3H4H6; A0A7L3I6Y5; A0A7L3KV16; A0A7L3L3C1; A0A7L3M5B9; A0A7L3NFE1; A0A7L3PPT4; A0A7L3QID2; A0A7L3RPI2; A0A7L3ST79; A0A7L3U378; A0A7L3VAR1; A0A7L3W396; A0A7L3X8C9; A0A7L3Z0M0; A0A7L4AJ46; A0A7L4BIP7; A0A7L4CC84; A0A7L4DQB0; A0A7L4EP40; A0A7L4HN55; A0A7L4J9W9; A0A7M4FIE6; A0A7N4PW14; A0A7T6ZK12; A0A811Z8F1; A0A850TFQ9; A0A850V5R2; A0A850W4N7; A0A850XKN3; A0A850YK23; A0A851A5U4; A0A851B4R4; A0A851CTC7; A0A851D320; A0A851E8C6; A0A851F1A8; A0A851JVZ7; A0A851K2P6; A0A851LU60; A0A851P5P0; A0A851R2P6; A0A851S6S6; A0A851T4V4; A0A851U0I3; A0A851VRP0; A0A851WCV5; A0A851Y321; A0A851Z9B4; A0A852A4Z3; A0A852AR86; A0A852BQ86; A0A852DLV7; A0A852E4W4; A0A852G2S2; A0A852L7H9; A0A852LWU6; A0A852MIU4; A0A852P924; A0A8B6ZZ93; A0A8B7FY80; A0A8B7JWS2; A0A8B7QXR8; A0A8B8VBY0; A0A8B9BC47; A0A8B9EY57; A0A8B9TCS0; A0A8C0BMH3; A0A8C0GIN8; A0A8C0IEG6; A0A8C0VMY6; A0A8C2VXZ2; A0A8C3I6V8; A0A8C3J5G4; A0A8C3QCS8; A0A8C3SWN5; A0A8C3V1H9; A0A8C4U9L8; A0A8C4W3F9; A0A8C5IQ83; A0A8C5L3Y8; A0A8C5UI70; A0A8C5Z473; A0A8C6AVT7; A0A8C6E309; A0A8C6J2B6; A0A8C7ELL8; A0A8C8AQ23; A0A8C8SAX1; A0A8C8TJI2; A0A8C9D802; A0A8C9EU06; A0A8C9HDT2; A0A8D0FEG6; A0A8D2DXS1; A0A8D2E312; A0A8D2J5F6; A0A8D2QDJ6; A0A8D2QMT1; A0A8I3W1I0; A0A8J4I2Z8; A0A8J4N6K5; A0A8J4NKS0; A0A8J4P196; A0A8J4U9Z8; A0A8K0BW04; A0A8K1GFZ5; A0A8M1G7Q7; A0A8S9EM85; A0A8V5H9G0; A0A973YLC1; A0A9F2R4N2; A0A9W2UUK2; A0A9W3F4H2; A0AA35L9Q0; A0AA40H6S4; A0AA40LS06; A5D961; A5PKA1; A6K1N6; aam:106497948; aful:116495117; aju:106984514; asn:102386754; B2RRX1; bacu:103015338; bom:102286048; bta:280979; ccan:109700700; cfa:403580; cfr:102514032; cpic:101941176; cpoc:100135470; cpoo:109314696; D5MU85; D7RIF5; dle:111170344; dord:105990935; ecb:100033878; elk:111145734; F6TIK4; F6UDX9; F7DIB7; fab:101813373; fca:101098507; G1MLH3; G3GVD0; G3QFP0; G8HY07; gfr:102041442; gga:396526; hai:109380220; hsa:60; I3MNL1; J3S3X5; J7H0T4; L5L2F8; L5LSF7; lav:100654618; lve:103077223; lww:102744309; M3WRZ7; M3YYU9; M7B7E7; maua:101844587; mcal:110295381; mcc:574285; mdo:100011313; mdo:100011351; mleu:105551087; mmu:11461; mmur:105868294; mni:105497365; mpuf:101686268; myd:102772396; nasi:112412020; nsu:110572001; O18840; oaa:100078865; oro:101375328; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pale:102884469; panu:101026869; pbi:103050159; pcad:112063645; pcw:110223114; pdic:114509151; pgut:117676791; pon:100173832; ptr:450133; pvp:105294565; Q11209; Q11211; Q1KLZ0; Q25PW9; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q58J72; Q5R1X3; Q5R582; Q5R6G0; Q5W9H6; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; R0LHA7; ray:107515934; rbb:108538237; rno:81822; S9YTS3; sbq:101037287; shr:100919051; ssc:414396; T1DP26; U3FXK3; U3KHC4; umr:103670086; V9P8F4; vpc:102534524; zab:102067189; zca:113932833" "FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling pathway; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; RHO GTPases activate IQGAPs; Cell-extracellular matrix interactions; MAP2K and MAPK activation; UCH proteinases; RHO GTPases Activate Formins; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; UCH proteinases; RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; EPHB-mediated forward signaling; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; RHO GTPases activate IQGAPs; RHOF GTPase cycle; B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; RHO GTPases Activate Formins; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Adherens junctions interactions; VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; MAP2K and MAPK activation; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; RHO GTPases activate IQGAPs; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; UCH proteinases; Adherens junctions interactions; RHO GTPases activate IQGAPs; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of annular gap junctions" "157" "11" "1.025" "1.008" "1.158" "1.043" "1.053" "1.087" "1.100" "1.094" "1.043" "10813.1" "11083.1" "10903.2" "12526.8" "11279.3" "11387.9" "11752.8" "11894.2" "11834.5" "11279.3" "" "" "" "" "" "" "" "" "" "" "10131.9" "9171.1" "10122.3" "9683.8" "9614.2" "10880.0" "10738.9" "10560.8" "11834.5" "10860.4" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-547053484993874983" "False" "High" "IsMasterProtein" "Q13085" "Acetyl-CoA carboxylase 1 OS=Homo sapiens OX=9606 GN=ACACA PE=1 SV=2" "0.000" "False" "109.726" "16" "35" "48" "35" "2346" "265.4" "6.37" "138.81" "35" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus" "other molecular function" "Pf00289, Pf00364, Pf01039, Pf02785, Pf02786, Pf08326, Pf21385" "31" "ENSG00000275176; ENSG00000278540" "ACACA" "B2RP68; B2ZZ90; hsa:31; Q13085; Q6KEV6; Q6XDA8; Q7Z2G8; Q7Z561; Q7Z563; Q7Z564; Q86WB2; Q86WB3" "AMP-activated protein kinase signaling; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Hereditary leiomyomatosis and renal cell carcinoma pathway; Mitochondrial fatty acid synthesis pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; 7q11.23 copy number variation syndrome; 17q12 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; ADHD and autism (ASD) linked metabolic pathways and SNP" "Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; ChREBP activates metabolic gene expression; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis" "24" "0" "1.004" "0.999" "1.017" "1.026" "1.015" "1.017" "0.994" "0.972" "0.997" "3974.7" "3991.0" "3972.0" "4040.9" "4077.7" "4033.9" "4043.7" "3951.3" "3863.1" "3960.9" "" "" "" "" "" "" "" "" "" "" "3724.2" "3302.5" "3687.5" "3123.8" "3475.7" "3854.0" "3694.9" "3508.4" "3863.1" "3813.8" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1518063030880020019" "False" "High" "IsMasterProtein" "P12814" "Alpha-actinin-1 OS=Homo sapiens OX=9606 GN=ACTN1 PE=1 SV=2" "0.000" "False" "108.657" "36" "29" "54" "20" "892" "103.0" "5.41" "170.12" "29" "cell adhesion;cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00307, Pf00435, Pf08726" "87" "ENSG00000072110" "ACTN1" "B3V8S3; B4DHH3; B7TY16; hsa:87; P12814; Q1HE25; Q9BTN1" "Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Ebola virus infection in host; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Regulation of actin cytoskeleton" "RHOD GTPase cycle; RHOF GTPase cycle; Platelet degranulation ; Nephrin family interactions; Syndecan interactions; RHOBTB2 GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "12" "0" "0.983" "1.013" "1.072" "1.026" "1.002" "1.025" "1.028" "1.059" "1.032" "3720.6" "3658.0" "3768.4" "3989.4" "3817.1" "3729.9" "3813.3" "3823.0" "3938.8" "3840.2" "" "" "" "" "" "" "" "" "" "" "3486.2" "3027.0" "3498.5" "3084.0" "3253.6" "3563.6" "3484.3" "3394.5" "3938.8" "3697.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1011353078992681906" "False" "High" "IsMasterProtein" "P49736" "DNA replication licensing factor MCM2 OS=Homo sapiens OX=9606 GN=MCM2 PE=1 SV=4" "0.000" "False" "108.354" "32" "27" "53" "27" "904" "101.8" "5.52" "151.92" "27" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf12619, Pf14551, Pf17207, Pf17855" "4171" "ENSG00000073111" "MCM2" "hsa:4171; P49736; Q14577; Q15023; Q8N2V1; Q969W7; Q96AE1; Q9BRM7" "Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication; 1p36 copy number variation syndrome" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "11" "0" "0.970" "0.947" "0.990" "0.952" "0.929" "1.017" "1.002" "1.013" "0.972" "4357.2" "4225.9" "4128.0" "4312.4" "4149.5" "4048.4" "4432.6" "4364.6" "4414.3" "4237.3" "" "" "" "" "" "" "" "" "" "" "4082.7" "3496.8" "3832.3" "3333.7" "3536.9" "3867.8" "4050.2" "3875.4" "4414.3" "4079.9" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5530158233237029042" "False" "High" "IsMasterProtein" "Q15075" "Early endosome antigen 1 OS=Homo sapiens OX=9606 GN=EEA1 PE=1 SV=2" "0.000" "False" "107.779" "25" "36" "40" "35" "1411" "162.4" "5.68" "138.64" "36" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363" "8411" "ENSG00000102189" "EEA1" "hsa:8411; Q14221; Q15075" "VEGFA-VEGFR2 signaling" "Toll Like Receptor 9 (TLR9) Cascade" "2" "0" "1.052" "0.969" "0.987" "1.059" "1.028" "1.013" "1.034" "1.034" "1.011" "4420.7" "4650.8" "4284.4" "4362.1" "4682.2" "4544.0" "4478.9" "4570.5" "4571.7" "4471.0" "" "" "" "" "" "" "" "" "" "" "4142.2" "3848.5" "3977.6" "3372.1" "3991.0" "4341.3" "4092.5" "4058.1" "4571.7" "4305.0" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7637669709604963095" "False" "High" "IsMasterProtein" "Q12888" "TP53-binding protein 1 OS=Homo sapiens OX=9606 GN=TP53BP1 PE=1 SV=2" "0.000" "False" "107.576" "21" "34" "40" "34" "1972" "213.4" "4.70" "145.27" "34" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09038, Pf18428" "7158" "ENSG00000067369" "TP53BP1" "F8VY86; hsa:7158; Q12888; Q2M1Z7; Q4LE46; Q5FWZ3; Q7Z3U4" "ATM signaling pathway; ATM signaling in development and disease" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); SUMOylation of transcription factors" "7" "0" "0.982" "0.966" "0.941" "1.006" "0.980" "0.968" "0.990" "0.997" "1.022" "5538.2" "5437.5" "5349.2" "5208.7" "5571.0" "5429.3" "5358.4" "5484.4" "5523.0" "5661.9" "" "" "" "" "" "" "" "" "" "" "5189.3" "4499.4" "4966.1" "4026.6" "4748.6" "5187.2" "4896.2" "4869.6" "5523.0" "5451.6" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-516006275001987462" "False" "High" "IsMasterProtein" "Q14566" "DNA replication licensing factor MCM6 OS=Homo sapiens OX=9606 GN=MCM6 PE=1 SV=1" "0.000" "False" "106.976" "40" "32" "51" "32" "821" "92.8" "5.41" "173.82" "32" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855, Pf18263" "4175" "ENSG00000076003" "MCM6" "B2R6H2; hsa:4175; Q13504; Q14566; Q99859" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "11" "0" "0.942" "0.995" "0.945" "0.929" "0.942" "0.947" "0.981" "0.960" "0.955" "4719.5" "4444.8" "4696.4" "4460.1" "4382.4" "4447.3" "4471.3" "4628.9" "4529.3" "4505.5" "" "" "" "" "" "" "" "" "" "" "4422.2" "3678.0" "4360.0" "3447.8" "3735.4" "4249.0" "4085.6" "4110.0" "4529.3" "4338.2" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6256395688163039861" "False" "High" "IsMasterProtein" "O75643" "U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Homo sapiens OX=9606 GN=SNRNP200 PE=1 SV=2" "0.000" "False" "106.031" "18" "38" "43" "37" "2136" "244.4" "6.06" "131.68" "38" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf02889, Pf18149, Pf21188" "23020" "ENSG00000144028" "SNRNP200" "hsa:23020; O75643; O94884; Q6NZY0; Q6PX59; Q8NBE6; Q96IF2; Q9H7S0" "2q11.2 copy number variation syndrome" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "1" "0.967" "1.031" "0.943" "0.955" "0.976" "1.025" "0.952" "0.959" "0.993" "6350.2" "6138.9" "6549.1" "5989.0" "6066.8" "6198.6" "6510.6" "6043.3" "6087.5" "6305.8" "" "" "" "" "" "" "" "" "" "" "5950.1" "5079.9" "6080.0" "4629.8" "5171.1" "5922.2" "5949.0" "5365.8" "6087.5" "6071.6" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2874142018275296018" "False" "High" "IsMasterProtein" "A6NHR9" "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SMCHD1 PE=1 SV=2" "0.000" "False" "105.148" "18" "36" "41" "36" "2005" "226.2" "7.30" "126.98" "36" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06470, Pf13589" "23347" "ENSG00000101596" "SMCHD1" "A6NHR9; O75141; Q6AHX6; Q6ZTQ8; Q9H6Q2; Q9UG39" "" "" "0" "0" "0.968" "1.019" "1.008" "1.024" "1.023" "1.006" "1.024" "1.020" "1.040" "5337.1" "5167.7" "5438.4" "5378.7" "5466.1" "5461.2" "5371.7" "5464.8" "5444.4" "5553.3" "" "" "" "" "" "" "" "" "" "" "5000.9" "4276.2" "5048.9" "4158.0" "4659.2" "5217.7" "4908.3" "4852.2" "5444.4" "5347.0" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-987846664266598251" "False" "High" "IsMasterProtein" "Q9NS87" "Kinesin-like protein KIF15 OS=Homo sapiens OX=9606 GN=KIF15 PE=1 SV=1" "0.000" "False" "103.891" "26" "37" "46" "37" "1388" "160.1" "6.00" "142.95" "37" "cell cycle OR cell proliferation;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00225, Pf15908" "56992" "ENSG00000163808; ENSG00000280610" "KIF15" "hsa:56992; Q17RV9; Q69YL6; Q96JX7; Q9H280; Q9NS87" "Gastric cancer network 1" "MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "4" "0" "0.993" "0.996" "1.024" "1.022" "0.993" "0.978" "0.960" "0.955" "1.017" "4158.7" "4128.8" "4140.3" "4259.4" "4250.2" "4129.2" "4068.0" "3992.4" "3973.1" "4230.6" "" "" "" "" "" "" "" "" "" "" "3896.7" "3416.5" "3843.7" "3292.7" "3622.8" "3945.0" "3717.1" "3544.9" "3973.1" "4073.5" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6634363274650926044" "False" "High" "IsMasterProtein" "Q14839" "Chromodomain-helicase-DNA-binding protein 4 OS=Homo sapiens OX=9606 GN=CHD4 PE=1 SV=2" "0.000" "False" "103.853" "19" "32" "47" "25" "1912" "217.9" "5.86" "146.07" "32" "cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf00628, Pf06461, Pf06465, Pf08073, Pf08074" "1108" "ENSG00000111642" "CHD4" "Q14839; Q8IXZ5" "Rett syndrome; Effect of progerin on genes involved in progeria" "Potential therapeutics for SARS; HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; NGF-stimulated transcription; RNA Polymerase I Transcription Initiation; Regulation of TP53 Activity through Acetylation" "9" "6" "0.944" "1.049" "0.900" "0.934" "0.913" "0.934" "0.881" "0.886" "0.967" "6810.1" "6430.3" "7143.7" "6130.3" "6362.1" "6216.9" "6361.3" "5999.1" "6035.7" "6584.7" "" "" "" "" "" "" "" "" "" "" "6381.1" "5321.0" "6632.0" "4739.0" "5422.9" "5939.6" "5812.6" "5326.6" "6035.7" "6340.1" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5926930809007955556" "False" "High" "IsMasterProtein" "Q92598" "Heat shock protein 105 kDa OS=Homo sapiens OX=9606 GN=HSPH1 PE=1 SV=1" "0.000" "False" "103.830" "34" "25" "45" "22" "858" "96.8" "5.39" "147.78" "25" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00012" "10808" "ENSG00000120694" "HSPH1" "B4DYH1; hsa:10808; O95739; Q5TBM6; Q5TBM7; Q5TBM8; Q92598; Q9UPC4" "" "Regulation of HSF1-mediated heat shock response; Scavenging by Class F Receptors" "2" "2" "0.958" "0.954" "0.968" "0.962" "0.970" "0.936" "0.958" "0.977" "0.985" "5170.0" "4952.4" "4931.2" "5006.3" "4974.5" "5014.4" "4841.2" "4953.6" "5051.2" "5092.3" "" "" "" "" "" "" "" "" "" "" "4844.2" "4098.0" "4578.0" "3870.1" "4240.2" "4790.7" "4423.5" "4398.3" "5051.2" "4903.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4874670657009698466" "False" "High" "IsMasterProtein" "Q6P2Q9" "Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens OX=9606 GN=PRPF8 PE=1 SV=2" "0.000" "False" "103.563" "14" "35" "47" "35" "2335" "273.4" "8.84" "135.79" "35" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01398, Pf08082, Pf08083, Pf08084, Pf10596, Pf10597, Pf10598, Pf12134" "10594" "ENSG00000174231; ENSG00000274442" "PRPF8" "hsa:10594; O14547; O75965; Q6P2Q9" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "0.984" "1.069" "0.974" "0.992" "1.015" "0.967" "0.965" "0.993" "1.038" "4427.9" "4356.5" "4734.6" "4311.3" "4394.0" "4492.4" "4281.5" "4274.2" "4398.7" "4597.4" "" "" "" "" "" "" "" "" "" "" "4148.9" "3605.0" "4395.5" "3332.8" "3745.3" "4292.1" "3912.1" "3795.1" "4398.7" "4426.6" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5561612098835552022" "False" "High" "IsMasterProtein" "P38646" "Stress-70 protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPA9 PE=1 SV=2" "0.000" "False" "103.232" "42" "25" "61" "24" "679" "73.6" "6.16" "202.56" "25" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00012" "3313" "ENSG00000113013" "HSPA9" "B2RCM1; hsa:3313; P30036; P31932; P38646; Q1HB43; Q53H23; Q6GU03; Q9BWB7; Q9UC56" "Parkin-ubiquitin proteasomal system pathway; Iron-sulfur cluster biogenesis" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Mitochondrial protein degradation; Mitochondrial protein import; Regulation of HSF1-mediated heat shock response; Cristae formation" "7" "0" "0.991" "0.984" "0.977" "0.999" "0.992" "0.962" "1.009" "1.012" "0.985" "5103.3" "5057.8" "5024.1" "4984.5" "5098.9" "5060.1" "4907.7" "5149.8" "5164.8" "5027.6" "" "" "" "" "" "" "" "" "" "" "4781.8" "4185.3" "4664.3" "3853.3" "4346.2" "4834.5" "4484.3" "4572.5" "5164.8" "4840.8" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2619416957405686977" "False" "High" "IsMasterProtein" "P49321" "Nuclear autoantigenic sperm protein OS=Homo sapiens OX=9606 GN=NASP PE=1 SV=2" "0.000" "False" "103.121" "37" "26" "52" "26" "788" "85.2" "4.30" "181.39" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10516" "4678" "ENSG00000132780" "NASP" "A8K6H2; B4DQP3; D3DQ07; F5H3J2; hsa:4678; P49321; Q53GW5; Q5T622; Q5T625; Q96A69; Q9BTW2" "" "" "0" "0" "1.051" "0.954" "0.950" "0.968" "1.002" "1.008" "1.041" "0.996" "1.001" "7331.8" "7705.7" "6998.2" "6964.6" "7098.0" "7344.8" "7392.4" "7634.0" "7303.7" "7336.4" "" "" "" "" "" "" "" "" "" "" "6869.9" "6376.3" "6496.9" "5383.9" "6050.2" "7017.3" "6754.7" "6778.2" "7303.7" "7063.9" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2651873567954206530" "False" "High" "IsMasterProtein" "Q9P2J5" "Leucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=LARS1 PE=1 SV=2" "0.000" "False" "102.930" "27" "30" "54" "30" "1176" "134.4" "7.30" "171.68" "30" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00133, Pf08264" "51520" "ENSG00000133706" "LARS1" "A2RRR4; A7E266; B4DJ10; hsa:51520; Q2TU79; Q9NSE1; Q9P2J5" "" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "2" "0" "0.987" "0.996" "0.988" "0.975" "1.007" "0.940" "0.953" "0.966" "0.969" "7078.0" "6982.5" "7048.4" "6992.2" "6902.0" "7129.1" "6652.5" "6742.0" "6835.4" "6859.7" "" "" "" "" "" "" "" "" "" "" "6632.1" "5777.9" "6543.5" "5405.3" "5883.1" "6811.2" "6078.6" "5986.3" "6835.4" "6604.9" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1213395878895108528" "False" "High" "IsMasterProtein" "P26038" "Moesin OS=Homo sapiens OX=9606 GN=MSN PE=1 SV=3" "0.000" "False" "101.803" "47" "34" "62" "25" "577" "67.8" "6.40" "179.59" "34" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "4478" "ENSG00000147065" "MSN" "hsa:4478; P26038" "Glial cell differentiation; AGE/RAGE pathway; Measles virus infection; 16p11.2 proximal deletion syndrome; Regulation of actin cytoskeleton" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Signaling by ALK fusions and activated point mutants" "10" "6" "1.055" "1.026" "0.993" "0.962" "0.966" "1.014" "1.010" "1.046" "0.989" "6956.1" "7336.4" "7137.8" "6904.2" "6694.3" "6717.0" "7055.7" "7029.0" "7272.6" "6882.6" "" "" "" "" "" "" "" "" "" "" "6517.8" "6070.8" "6626.6" "5337.3" "5706.1" "6417.5" "6447.0" "6241.1" "7272.6" "6627.0" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1034815253104013464" "False" "High" "IsMasterProtein" "P50990" "T-complex protein 1 subunit theta OS=Homo sapiens OX=9606 GN=CCT8 PE=1 SV=4" "0.000" "False" "101.554" "53" "26" "68" "26" "548" "59.6" "5.60" "224.15" "26" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00118" "10694" "ENSG00000156261; ENSG00000291533" "CCT8" "A6NN54; B4DEM7; B4DQH4; hsa:10694; P50990; Q4VBP8" "16p11.2 proximal deletion syndrome" "Neutrophil degranulation; Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "8" "0" "0.961" "0.975" "0.951" "0.944" "0.941" "0.924" "0.935" "0.955" "0.930" "7028.2" "6755.3" "6852.7" "6684.8" "6633.9" "6610.2" "6497.0" "6569.1" "6712.8" "6537.0" "" "" "" "" "" "" "" "" "" "" "6585.4" "5589.9" "6361.9" "5167.6" "5654.5" "6315.5" "5936.6" "5832.7" "6712.8" "6294.2" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4445993330794884217" "False" "High" "IsMasterProtein" "P54577" "Tyrosine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=YARS1 PE=1 SV=4" "0.000" "False" "100.761" "51" "26" "51" "26" "528" "59.1" "7.05" "171.67" "26" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00579, Pf01588" "8565" "ENSG00000134684" "YARS1" "B3KWK4; D3DPQ4; hsa:8565; O43276; P54577; Q53EN1" "Nephrotic syndrome" "Cytosolic tRNA aminoacylation" "2" "0" "0.988" "1.018" "0.988" "0.999" "0.993" "0.938" "0.991" "0.971" "1.003" "5647.4" "5580.6" "5751.7" "5579.7" "5643.9" "5609.5" "5295.1" "5598.4" "5486.0" "5664.8" "" "" "" "" "" "" "" "" "" "" "5291.6" "4617.8" "5339.7" "4313.4" "4810.7" "5359.3" "4838.3" "4970.8" "5486.0" "5454.5" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7881821209807726399" "False" "High" "IsMasterProtein" "O75153" "Clustered mitochondria protein homolog OS=Homo sapiens OX=9606 GN=CLUH PE=1 SV=2" "0.000" "False" "100.373" "24" "32" "51" "32" "1309" "146.6" "6.13" "159.28" "32" "cell organization and biogenesis" "other cell component" "nucleic acid binding activity" "Pf12807, Pf13236, Pf13374, Pf13424, Pf15044" "23277" "ENSG00000132361" "CLUH" "hsa:23277; O75153; Q6AHY2; Q6P3X7; Q6ZUG8; Q8N4U7; Q9BTA3; Q9H979" "Translation factors" "" "1" "0" "1.005" "0.993" "1.012" "0.983" "0.978" "0.966" "0.929" "0.939" "0.977" "3543.0" "3561.2" "3518.0" "3586.9" "3483.2" "3465.1" "3421.3" "3292.1" "3327.2" "3459.8" "" "" "" "" "" "" "" "" "" "" "3319.8" "2946.9" "3266.0" "2772.9" "2969.0" "3310.6" "3126.2" "2923.1" "3327.2" "3331.3" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3851021478040607723" "False" "High" "IsMasterProtein" "P31939" "Bifunctional purine biosynthesis protein ATIC OS=Homo sapiens OX=9606 GN=ATIC PE=1 SV=3" "0.000" "False" "100.314" "58" "27" "51" "27" "592" "64.6" "6.71" "167.31" "27" "other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf01808, Pf02142" "471" "ENSG00000138363" "ATIC" "A8K202; E9PBU3; hsa:471; P31939; Q13856; Q53S28" "One-carbon metabolism" "Signaling by ALK fusions and activated point mutants; Purine ribonucleoside monophosphate biosynthesis" "3" "0" "0.952" "0.997" "0.899" "0.969" "0.997" "0.876" "0.954" "1.010" "0.938" "4932.4" "4696.3" "4919.2" "4435.9" "4779.2" "4916.2" "4321.5" "4706.8" "4982.9" "4624.9" "" "" "" "" "" "" "" "" "" "" "4621.7" "3886.1" "4566.8" "3429.1" "4073.7" "4697.0" "3948.7" "4179.1" "4982.9" "4453.1" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6896953880380314494" "False" "High" "IsMasterProtein" "P55072" "Transitional endoplasmic reticulum ATPase OS=Homo sapiens OX=9606 GN=VCP PE=1 SV=4" "0.000" "False" "100.184" "39" "31" "53" "31" "806" "89.3" "5.26" "160.65" "31" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00004, Pf02359, Pf02933, Pf17862" "7415" "ENSG00000165280" "VCP" "B2R5T8; P55072; Q0V924; Q2TAI5; Q969G7; Q9UCD5; V9HW80" "Alstrom syndrome; Clock-controlled autophagy in bone metabolism; HDAC6 interactions in the central nervous system" "Neutrophil degranulation; ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; Neddylation; KEAP1-NFE2L2 pathway; RHOH GTPase cycle; E3 ubiquitin ligases ubiquitinate target proteins; Aggrephagy; Attachment and Entry; Attachment and Entry; Ovarian tumor domain proteases; Josephin domain DUBs; Protein methylation; HSF1 activation; Translesion Synthesis by POLH; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "21" "0" "0.986" "1.018" "1.011" "1.000" "0.972" "0.979" "0.985" "0.989" "0.972" "6467.5" "6374.2" "6585.3" "6539.9" "6466.3" "6288.7" "6332.2" "6370.5" "6393.9" "6288.3" "" "" "" "" "" "" "" "" "" "" "6060.1" "5274.6" "6113.6" "5055.6" "5511.7" "6008.2" "5786.0" "5656.4" "6393.9" "6054.8" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4773459124454051332" "False" "High" "IsMasterProtein" "P49915" "GMP synthase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=GMPS PE=1 SV=1" "0.000" "False" "100.118" "41" "25" "46" "25" "693" "76.7" "6.87" "138.76" "25" "other metabolic processes" "cytosol" "other molecular function" "Pf00117, Pf00958, Pf02540" "8833" "ENSG00000163655" "GMPS" "A8K639; B4DXV7; F8W720; hsa:8833; P49915" "" "Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "2" "0" "0.943" "1.010" "0.969" "0.954" "1.011" "0.970" "0.971" "0.981" "0.968" "3445.1" "3247.3" "3479.3" "3338.7" "3285.6" "3483.6" "3341.6" "3344.4" "3380.5" "3334.8" "" "" "" "" "" "" "" "" "" "" "3228.1" "2687.1" "3230.1" "2580.9" "2800.5" "3328.3" "3053.4" "2969.5" "3380.5" "3210.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9133260577685858014" "False" "High" "IsMasterProtein" "O00410" "Importin-5 OS=Homo sapiens OX=9606 GN=IPO5 PE=1 SV=4" "0.000" "False" "99.332" "31" "27" "48" "27" "1097" "123.6" "4.94" "155.92" "27" "transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02985, Pf18808, Pf18816, Pf18829" "3843" "ENSG00000065150" "IPO5" "B4DZA0; hsa:3843; O00410; O15257; Q5T578; Q86XC7" "" "vRNP Assembly" "1" "0" "0.984" "1.020" "1.031" "1.002" "0.996" "0.985" "0.999" "0.991" "0.999" "4833.4" "4754.1" "4931.1" "4981.3" "4842.8" "4815.3" "4759.0" "4828.8" "4789.1" "4827.0" "" "" "" "" "" "" "" "" "" "" "4528.9" "3934.0" "4577.9" "3850.7" "4127.9" "4600.6" "4348.4" "4287.5" "4789.1" "4647.7" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5753903603639706733" "False" "High" "IsMasterProtein" "Q15021" "Condensin complex subunit 1 OS=Homo sapiens OX=9606 GN=NCAPD2 PE=1 SV=3" "0.000" "False" "99.139" "25" "33" "42" "32" "1401" "157.1" "6.61" "141.94" "33" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12717, Pf12922" "9918" "ENSG00000010292" "NCAPD2" "D3DUR4; hsa:9918; Q15021; Q8N6U3" "" "Condensation of Prometaphase Chromosomes" "1" "1" "0.970" "1.016" "0.935" "0.961" "0.971" "0.887" "0.875" "0.908" "0.956" "6806.9" "6600.3" "6914.2" "6366.9" "6540.3" "6606.4" "6036.2" "5958.6" "6178.0" "6504.2" "" "" "" "" "" "" "" "" "" "" "6378.0" "5461.6" "6418.9" "4921.9" "5574.8" "6311.8" "5515.5" "5290.6" "6178.0" "6262.6" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5778599060552415361" "False" "High" "IsMasterProtein" "P52272" "Heterogeneous nuclear ribonucleoprotein M OS=Homo sapiens OX=9606 GN=HNRNPM PE=1 SV=3" "0.000" "False" "99.053" "41" "27" "82" "27" "730" "77.5" "8.70" "198.35" "27" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11532" "4670" "ENSG00000099783" "HNRNPM" "hsa:4670; P52272; Q15584; Q8WZ44; Q96H56; Q9BWL9; Q9Y492" "mRNA processing" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "4" "0" "1.029" "0.992" "1.025" "1.011" "0.996" "0.931" "0.882" "0.965" "1.001" "8993.6" "9258.4" "8918.8" "9221.2" "9088.6" "8961.6" "8376.2" "7932.8" "8677.4" "8999.9" "" "" "" "" "" "" "" "" "" "" "8427.0" "7661.2" "8279.9" "7128.4" "7746.9" "8561.9" "7653.6" "7043.5" "8677.4" "8665.7" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3973589334991488607" "False" "High" "IsMasterProtein" "Cont_P04264" "Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6" "0.000" "True" "98.927" "35" "27" "50" "20" "644" "66.0" "8.12" "154.95" "27" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038, Pf16208, Pf16210" "3848" "ENSG00000167768" "KRT1" "B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298" "Corticotropin-releasing hormone signaling pathway" "Formation of the cornified envelope; Neutrophil degranulation" "4" "7" "0.623" "0.259" "0.491" "0.306" "0.338" "2.947" "0.513" "0.145" "0.632" "8890.4" "5542.3" "2299.9" "4369.4" "2716.1" "3004.0" "26198.4" "4561.4" "1293.5" "5621.1" "" "" "" "" "" "" "" "" "" "" "8330.3" "4586.2" "2135.2" "3377.8" "2315.1" "2870.1" "23938.3" "4050.1" "1293.5" "5412.3" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4218486089971029806" "False" "High" "IsMasterProtein" "Q92608" "Dedicator of cytokinesis protein 2 OS=Homo sapiens OX=9606 GN=DOCK2 PE=1 SV=2" "0.000" "False" "98.356" "16" "29" "45" "29" "1830" "211.8" "6.87" "137.41" "29" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf06920, Pf07653, Pf14429, Pf16172, Pf20421, Pf20422" "1794" "ENSG00000134516" "DOCK2" "hsa:1794; Q2M3I0; Q92608; Q96AK7" "Chemokine signaling pathway" "Neutrophil degranulation; RHOA GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; Factors involved in megakaryocyte development and platelet production; Nef and signal transduction" "8" "0" "1.004" "1.046" "0.951" "0.993" "0.983" "0.837" "0.845" "0.861" "0.967" "5727.3" "5753.0" "5989.4" "5446.2" "5685.9" "5628.3" "4794.2" "4839.5" "4929.7" "5538.4" "" "" "" "" "" "" "" "" "" "" "5366.5" "4760.6" "5560.4" "4210.1" "4846.5" "5377.3" "4380.6" "4297.0" "4929.7" "5332.7" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7742249596596208262" "False" "High" "IsMasterProtein" "Q7KZF4" "Staphylococcal nuclease domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SND1 PE=1 SV=1" "0.000" "False" "98.334" "34" "30" "54" "30" "910" "101.9" "7.17" "174.04" "30" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00565, Pf00567" "27044" "ENSG00000197157" "SND1" "hsa:27044; Q13122; Q7KZF4; Q96AG0" "VEGFA-VEGFR2 signaling" "Signaling by BRAF and RAF1 fusions" "2" "0" "0.999" "1.036" "1.055" "1.049" "1.066" "1.117" "1.147" "1.118" "1.073" "4874.3" "4869.6" "5048.3" "5144.1" "5114.4" "5195.5" "5444.7" "5589.1" "5449.8" "5232.3" "" "" "" "" "" "" "" "" "" "" "4567.2" "4029.5" "4686.7" "3976.6" "4359.3" "4963.8" "4975.0" "4962.5" "5449.8" "5037.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-795610127174802190" "False" "High" "IsMasterProtein" "P15311" "Ezrin OS=Homo sapiens OX=9606 GN=EZR PE=1 SV=4" "0.000" "False" "98.312" "38" "30" "66" "20" "586" "69.4" "6.27" "183.98" "30" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "7430" "ENSG00000092820" "EZR" "E1P5A8; hsa:7430; P15311; P23714; Q4VX75; Q96CU8; Q9NSJ4" "Pathogenic Escherichia coli infection; AGE/RAGE pathway; VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome; CCL18 signaling pathway; Regulation of actin cytoskeleton; GDNF signaling" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Netrin-1 signaling" "11" "1" "1.016" "1.020" "0.958" "0.929" "0.966" "0.990" "1.006" "1.022" "0.966" "5549.9" "5640.7" "5662.2" "5315.7" "5154.4" "5361.5" "5496.4" "5581.5" "5670.5" "5362.6" "" "" "" "" "" "" "" "" "" "" "5200.3" "4667.6" "5256.7" "4109.3" "4393.5" "5122.4" "5022.3" "4955.8" "5670.5" "5163.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6942352143814958774" "False" "High" "IsMasterProtein" "P49368" "T-complex protein 1 subunit gamma OS=Homo sapiens OX=9606 GN=CCT3 PE=1 SV=4" "0.000" "False" "97.998" "43" "23" "66" "23" "545" "60.5" "6.49" "200.60" "23" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "7203" "ENSG00000163468" "CCT3" "A6NE14; hsa:7203; P49368; Q5SZY1; Q9BR64" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "7" "0" "0.932" "0.948" "0.962" "0.934" "0.918" "0.916" "0.920" "0.891" "0.911" "7868.9" "7337.1" "7458.7" "7571.9" "7350.5" "7220.4" "7205.5" "7236.7" "7014.1" "7165.2" "" "" "" "" "" "" "" "" "" "" "7373.1" "6071.4" "6924.4" "5853.5" "6265.4" "6898.4" "6583.9" "6425.5" "7014.1" "6899.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6102726942936219024" "False" "High" "IsMasterProtein" "Q14152" "Eukaryotic translation initiation factor 3 subunit A OS=Homo sapiens OX=9606 GN=EIF3A PE=1 SV=1" "0.000" "False" "97.978" "30" "40" "64" "40" "1382" "166.5" "6.79" "162.02" "40" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01399" "8661" "ENSG00000107581" "EIF3A" "B1AMV5; B4DYS1; F5H335; hsa:8661; O00653; Q14152; Q15778" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; NF1 copy number variation syndrome" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "9" "0" "1.022" "1.021" "0.915" "0.915" "0.897" "1.164" "1.210" "1.131" "1.037" "5249.3" "5364.1" "5360.6" "4801.8" "4804.5" "4710.2" "6109.8" "6353.8" "5935.5" "5441.0" "" "" "" "" "" "" "" "" "" "" "4918.6" "4438.7" "4976.6" "3712.0" "4095.2" "4500.1" "5582.8" "5641.5" "5935.5" "5239.0" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6625268949045148761" "False" "High" "IsMasterProtein" "Q8N163" "Cell cycle and apoptosis regulator protein 2 OS=Homo sapiens OX=9606 GN=CCAR2 PE=1 SV=2" "0.000" "False" "97.919" "34" "30" "54" "30" "923" "102.8" "5.22" "162.07" "30" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf14443, Pf14444, Pf19256, Pf19257" "57805" "ENSG00000158941" "CCAR2" "A6NL03; B2RB79; D3DSR6; hsa:57805; Q6P0Q9; Q8N163; Q8N3G7; Q8N8M1; Q8TF34; Q9H9Q9; Q9HD12; Q9NT55" "TAR syndrome" "Regulation of HSF1-mediated heat shock response" "2" "0" "1.008" "0.977" "0.956" "0.969" "0.962" "0.929" "0.935" "0.949" "0.981" "6355.1" "6406.2" "6206.4" "6073.1" "6157.4" "6113.9" "5905.7" "5942.4" "6029.1" "6234.8" "" "" "" "" "" "" "" "" "" "" "5954.7" "5301.1" "5761.9" "4694.8" "5248.4" "5841.3" "5396.2" "5276.3" "6029.1" "6003.2" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6568070672358433938" "False" "High" "IsMasterProtein" "Q00341" "Vigilin OS=Homo sapiens OX=9606 GN=HDLBP PE=1 SV=3" "0.000" "False" "97.863" "26" "32" "40" "32" "1268" "141.4" "6.87" "129.68" "32" "other metabolic processes;transport" "non-structural extracellular;plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "3069" "ENSG00000115677" "HDLBP" "B4DTQ2; E7EM71; hsa:3069; Q00341; Q53QU2; Q9UCY3" "2q37 copy number variation syndrome" "HDL clearance" "2" "0" "0.990" "1.017" "0.993" "1.008" "1.033" "1.043" "1.019" "1.019" "1.026" "5894.0" "5837.0" "5993.9" "5854.4" "5942.6" "6088.0" "6147.3" "6004.6" "6005.5" "6046.5" "" "" "" "" "" "" "" "" "" "" "5522.6" "4830.1" "5564.6" "4525.7" "5065.3" "5816.5" "5617.0" "5331.5" "6005.5" "5821.9" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2890284807861643792" "False" "High" "IsMasterProtein" "P22102" "Trifunctional purine biosynthetic protein adenosine-3 OS=Homo sapiens OX=9606 GN=GART PE=1 SV=1" "0.000" "False" "97.406" "28" "27" "49" "27" "1010" "107.7" "6.70" "167.82" "27" "other metabolic processes;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00551, Pf00586, Pf01071, Pf02769, Pf02843, Pf02844" "2618" "ENSG00000159131; ENSG00000262473" "GART" "A8K945; A8KA32; D3DSF3; D3DSF4; hsa:2618; O14659; P22102; Q52M77" "Folate metabolism; One-carbon metabolism; Metabolic reprogramming in colon cancer" "Purine ribonucleoside monophosphate biosynthesis" "4" "0" "0.955" "0.991" "0.969" "0.954" "0.972" "0.918" "0.946" "0.959" "0.952" "6438.9" "6146.3" "6384.0" "6238.4" "6141.7" "6259.9" "5912.7" "6090.5" "6177.4" "6131.4" "" "" "" "" "" "" "" "" "" "" "6033.3" "5086.0" "5926.7" "4822.6" "5235.0" "5980.7" "5402.7" "5407.7" "6177.4" "5903.7" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2847148615950550488" "False" "High" "IsMasterProtein" "P20700" "Lamin-B1 OS=Homo sapiens OX=9606 GN=LMNB1 PE=1 SV=2" "0.000" "False" "96.547" "45" "25" "50" "23" "586" "66.4" "5.16" "154.39" "25" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;nucleus" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00038, Pf00932" "4001" "ENSG00000113368" "LMNB1" "B2R6J6; hsa:4001; P20700; Q3SYN7; Q96EI6" "Fas ligand pathway and stress induction of heat shock proteins; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "Meiotic synapsis; RHOD GTPase cycle; RHOF GTPase cycle; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina; Breakdown of the nuclear lamina; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "14" "1" "1.038" "1.061" "1.165" "1.182" "1.169" "1.696" "1.852" "1.787" "1.334" "3475.1" "3608.1" "3686.6" "4049.6" "4107.9" "4062.0" "5893.3" "6436.5" "6210.8" "4636.3" "" "" "" "" "" "" "" "" "" "" "3256.2" "2985.6" "3422.6" "3130.5" "3501.4" "3880.9" "5384.9" "5714.9" "6210.8" "4464.1" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8649453304125061400" "False" "High" "IsMasterProtein" "Q12906" "Interleukin enhancer-binding factor 3 OS=Homo sapiens OX=9606 GN=ILF3 PE=1 SV=3" "0.000" "False" "96.465" "34" "26" "48" "21" "894" "95.3" "8.76" "131.70" "26" "protein metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf07528, Pf20965" "3609" "ENSG00000129351" "ILF3" "A8K6F2; G5E9M5; hsa:3609; O43409; Q12906; Q6P1X1; Q86XY7; Q99544; Q99545; Q9BZH4; Q9BZH5; Q9NQ95; Q9NQ96; Q9NQ97; Q9NQ98; Q9NQ99; Q9NQA0; Q9NQA1; Q9NQA2; Q9NRN2; Q9NRN3; Q9NRN4; Q9UMZ9; Q9UN00; Q9UN84; Q9UNA2" "" "PKR-mediated signaling; Regulation of CDH11 gene transcription" "2" "3" "1.049" "1.070" "1.068" "1.046" "1.028" "0.980" "1.080" "1.083" "1.049" "4630.9" "4859.7" "4956.9" "4944.0" "4845.2" "4760.0" "4539.5" "5000.4" "5016.3" "4859.0" "" "" "" "" "" "" "" "" "" "" "4339.1" "4021.4" "4601.9" "3821.9" "4129.9" "4547.8" "4147.9" "4439.9" "5016.3" "4678.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8336959389003651340" "False" "High" "IsMasterProtein" "Q9NZJ4" "Sacsin OS=Homo sapiens OX=9606 GN=SACS PE=1 SV=2" "0.000" "False" "95.237" "7" "33" "38" "33" "4579" "520.8" "7.05" "109.59" "33" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00240, Pf05168" "26278" "ENSG00000151835" "SACS" "hsa:26278; O94835; Q5T9J5; Q5T9J7; Q5T9J8; Q68DF5; Q6MZR4; Q8NBF9; Q9NZJ4" "13q12.12 copy number variation" "" "1" "0" "0.987" "1.054" "1.083" "1.083" "1.071" "1.037" "1.055" "0.977" "1.037" "2422.3" "2390.4" "2553.9" "2623.9" "2622.7" "2593.7" "2512.7" "2555.5" "2367.2" "2511.1" "" "" "" "" "" "" "" "" "" "" "2269.7" "1978.0" "2371.0" "2028.4" "2235.5" "2478.0" "2295.9" "2269.0" "2367.2" "2417.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4347150339173577721" "False" "High" "IsMasterProtein" "Q92878" "DNA repair protein RAD50 OS=Homo sapiens OX=9606 GN=RAD50 PE=1 SV=1" "0.000" "False" "94.972" "23" "33" "44" "33" "1312" "153.8" "6.89" "134.98" "33" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04423, Pf13476, Pf13558" "10111" "ENSG00000113522" "RAD50" "B9EGF5; hsa:10111; O43254; Q6GMT7; Q6P5X3; Q92878; Q9UP86" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; Joubert syndrome; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; DNA damage response" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Sensing of DNA Double Strand Breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ)" "29" "0" "0.960" "1.006" "0.980" "0.999" "0.975" "0.970" "0.985" "0.980" "1.001" "4630.4" "4444.2" "4658.0" "4537.9" "4627.7" "4515.4" "4492.4" "4560.0" "4539.9" "4633.5" "" "" "" "" "" "" "" "" "" "" "4338.6" "3677.5" "4324.4" "3508.0" "3944.6" "4314.0" "4104.8" "4048.8" "4539.9" "4461.4" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5104969040472016970" "False" "High" "IsMasterProtein" "Q13576" "Ras GTPase-activating-like protein IQGAP2 OS=Homo sapiens OX=9606 GN=IQGAP2 PE=1 SV=4" "0.000" "False" "94.109" "20" "31" "39" "29" "1575" "180.5" "5.64" "122.79" "31" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00307, Pf00612, Pf00616, Pf03836" "10788" "ENSG00000145703" "IQGAP2" "A8K4V1; B7Z8A4; hsa:10788; J3KR91; Q13576" "Ciliary landscape; G13 signaling pathway" "Neutrophil degranulation; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RHO GTPases activate IQGAPs" "7" "0" "1.033" "1.059" "1.015" "1.017" "1.034" "0.997" "0.948" "0.989" "1.048" "2402.2" "2481.2" "2543.2" "2439.1" "2444.1" "2484.1" "2395.5" "2277.8" "2376.8" "2516.9" "" "" "" "" "" "" "" "" "" "" "2250.8" "2053.2" "2361.1" "1885.5" "2083.3" "2373.3" "2188.8" "2022.4" "2376.8" "2423.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4258123771778816743" "False" "High" "IsMasterProtein" "P55265" "Double-stranded RNA-specific adenosine deaminase OS=Homo sapiens OX=9606 GN=ADAR PE=1 SV=4" "0.000" "False" "94.030" "25" "28" "43" "28" "1226" "136.0" "8.65" "127.25" "28" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf02137, Pf02295" "103" "ENSG00000160710" "ADAR" "B1AQQ9; B1AQR0; D3DV76; hsa:103; O15223; O43859; O43860; P55265; Q9BYM3; Q9BYM4" "Measles virus infection; Cytosolic DNA-sensing pathway" "PKR-mediated signaling; Interferon alpha/beta signaling; C6 deamination of adenosine; Formation of editosomes by ADAR proteins" "6" "0" "0.995" "1.055" "1.023" "1.060" "1.072" "1.071" "1.042" "1.056" "1.056" "4508.8" "4486.1" "4757.0" "4611.2" "4781.3" "4834.3" "4830.1" "4699.5" "4759.8" "4760.3" "" "" "" "" "" "" "" "" "" "" "4224.8" "3712.2" "4416.3" "3564.7" "4075.4" "4618.7" "4413.4" "4172.7" "4759.8" "4583.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3418914028943411131" "False" "High" "IsMasterProtein" "P29144" "Tripeptidyl-peptidase 2 OS=Homo sapiens OX=9606 GN=TPP2 PE=1 SV=4" "0.000" "False" "93.831" "25" "29" "44" "29" "1249" "138.3" "6.32" "128.54" "29" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00082, Pf12580, Pf12583, Pf21223, Pf21316" "7174" "ENSG00000134900" "TPP2" "hsa:7174; P29144; Q5VZU8" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.988" "1.022" "0.979" "1.025" "1.003" "0.973" "1.011" "0.974" "0.982" "3434.2" "3391.8" "3508.2" "3363.5" "3521.0" "3445.4" "3341.8" "3470.4" "3343.8" "3371.4" "" "" "" "" "" "" "" "" "" "" "3217.8" "2806.6" "3256.9" "2600.1" "3001.2" "3291.7" "3053.5" "3081.4" "3343.8" "3246.2" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4952006714438079555" "False" "High" "IsMasterProtein" "Q9Y4L1" "Hypoxia up-regulated protein 1 OS=Homo sapiens OX=9606 GN=HYOU1 PE=1 SV=1" "0.000" "False" "93.539" "33" "29" "48" "29" "999" "111.3" "5.22" "155.72" "29" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "other molecular function" "Pf00012" "10525" "ENSG00000149428; ENSG00000280682" "HYOU1" "A8C1Z0; B7Z909; hsa:10525; Q2I204; Q53H25; Q9Y4L1" "VEGFA-VEGFR2 signaling" "XBP1(S) activates chaperone genes; Scavenging by Class F Receptors" "3" "0" "1.006" "0.996" "0.980" "0.971" "0.955" "0.914" "0.949" "0.962" "0.974" "5914.7" "5949.0" "5888.9" "5795.3" "5744.1" "5646.8" "5403.4" "5611.5" "5692.0" "5762.1" "" "" "" "" "" "" "" "" "" "" "5542.1" "4922.7" "5467.1" "4480.0" "4896.1" "5395.0" "4937.3" "4982.5" "5692.0" "5548.1" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-806880739347862445" "False" "High" "IsMasterProtein" "Q71U36" "Tubulin alpha-1A chain OS=Homo sapiens OX=9606 GN=TUBA1A PE=1 SV=1" "0.000" "False" "93.489" "58" "20" "97" "1" "451" "50.1" "5.06" "314.19" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7846" "ENSG00000167552" "TUBA1A" "A8K0B8; G3V1U9; hsa:7846; P04687; P05209; Q71U36" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease; PAFAH1B1 copy number variation" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Recycling pathway of L1; Aggrephagy; COPI-mediated anterograde transport; Intraflagellar transport; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Sealing of the nuclear envelope (NE) by ESCRT-III; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "42" "16" "1.006" "1.006" "0.990" "0.999" "1.017" "0.915" "0.909" "0.948" "0.967" "7547.8" "7591.5" "7592.5" "7474.9" "7539.4" "7677.8" "6910.0" "6863.9" "7152.2" "7296.4" "" "" "" "" "" "" "" "" "" "" "7072.3" "6281.9" "7048.7" "5778.5" "6426.3" "7335.5" "6313.9" "6094.5" "7152.2" "7025.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3002712347046388220" "False" "High" "IsMasterProtein" "P78371" "T-complex protein 1 subunit beta OS=Homo sapiens OX=9606 GN=CCT2 PE=1 SV=4" "0.000" "False" "93.455" "52" "23" "66" "23" "535" "57.5" "6.46" "193.35" "23" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00118" "10576" "ENSG00000166226" "CCT2" "A8K402; B5BTY7; B7Z243; B7Z7K4; B7ZAT2; hsa:10576; P78371; Q14D36; Q6IAT3" "16p11.2 proximal deletion syndrome" "Neutrophil degranulation; Formation of tubulin folding intermediates by CCT/TriC; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC; BBSome-mediated cargo-targeting to cilium; RHOBTB1 GTPase cycle" "10" "0" "0.921" "0.928" "0.915" "0.909" "0.970" "0.908" "0.935" "0.950" "0.927" "5955.1" "5484.9" "5528.7" "5447.5" "5414.2" "5773.8" "5405.7" "5566.7" "5659.9" "5521.8" "" "" "" "" "" "" "" "" "" "" "5579.9" "4538.7" "5132.7" "4211.2" "4614.9" "5516.3" "4939.4" "4942.7" "5659.9" "5316.7" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7115142250704838097" "False" "High" "IsMasterProtein" "P08670" "Vimentin OS=Homo sapiens OX=9606 GN=VIM PE=1 SV=4" "0.000" "False" "92.974" "59" "28" "57" "27" "466" "53.6" "5.12" "172.34" "28" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00038, Pf04732" "7431" "ENSG00000026025" "VIM" "B0YJC2; D3DRU4; hsa:7431; P08670; Q15867; Q15868; Q15869; Q548L2; Q6LER9; Q8N850; Q96ML2; Q9NTM3" "Allograft rejection; Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Mammary gland development pathway - Puberty (Stage 2 of 4); Apoptosis-related network due to altered Notch3 in ovarian cancer; Striated muscle contraction pathway; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Ciliary landscape; Burn wound healing; CCL18 signaling pathway; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; HDAC6 interactions in the central nervous system; T-cell receptor signaling pathway" "Aggrephagy; Interleukin-4 and Interleukin-13 signaling; Chaperone Mediated Autophagy; Late endosomal microautophagy; Striated Muscle Contraction; RHOBTB1 GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins" "21" "1" "1.030" "0.981" "1.179" "1.169" "1.193" "1.838" "1.888" "1.788" "1.298" "4825.6" "4972.2" "4731.6" "5688.9" "5640.5" "5758.2" "8869.7" "9111.6" "8628.3" "6265.3" "" "" "" "" "" "" "" "" "" "" "4521.6" "4114.4" "4392.7" "4397.8" "4807.8" "5501.4" "8104.5" "8090.2" "8628.3" "6032.6" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3629072451512354259" "False" "High" "IsMasterProtein" "P52701" "DNA mismatch repair protein Msh6 OS=Homo sapiens OX=9606 GN=MSH6 PE=1 SV=2" "0.000" "False" "92.841" "21" "27" "37" "27" "1360" "152.7" "6.90" "121.14" "27" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00488, Pf00855, Pf01624, Pf05188, Pf05190, Pf05192" "2956" "ENSG00000116062" "MSH6" "B4DF41; B4E3I4; F5H2F9; hsa:2956; O43706; O43917; P52701; Q8TCX4; Q9BTB5" "Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Chromosomal and microsatellite instability in colorectal cancer ; DNA repair pathways, full network; DNA mismatch repair" "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6" "8" "0" "0.975" "0.974" "0.955" "0.975" "0.969" "0.968" "0.938" "0.957" "0.981" "4514.2" "4403.2" "4398.0" "4312.6" "4401.0" "4374.3" "4369.9" "4232.8" "4319.4" "4428.7" "" "" "" "" "" "" "" "" "" "" "4229.8" "3643.6" "4083.0" "3333.8" "3751.3" "4179.2" "3992.9" "3758.3" "4319.4" "4264.2" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6625337675714682058" "False" "High" "IsMasterProtein" "P33176" "Kinesin-1 heavy chain OS=Homo sapiens OX=9606 GN=KIF5B PE=1 SV=1" "0.000" "False" "92.678" "30" "26" "43" "19" "963" "109.6" "6.51" "128.85" "26" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3799" "ENSG00000170759" "KIF5B" "A0AVB2; hsa:3799; P33176; Q5VZ85" "Alzheimer's disease and miRNA effects; Envelope proteins and their potential roles in EDMD physiopathology; Insulin signaling; CCL18 signaling pathway; Alzheimer's disease" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Signaling by ALK fusions and activated point mutants; Insulin processing; RHO GTPases activate KTN1" "11" "3" "1.008" "0.999" "1.003" "0.998" "0.981" "0.997" "0.989" "0.976" "0.990" "4318.0" "4352.4" "4314.0" "4330.7" "4310.7" "4234.1" "4306.9" "4270.6" "4212.2" "4273.5" "" "" "" "" "" "" "" "" "" "" "4045.9" "3601.5" "4005.0" "3347.8" "3674.3" "4045.3" "3935.3" "3791.9" "4212.2" "4114.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1205545228874989707" "False" "High" "IsMasterProtein" "Q92900" "Regulator of nonsense transcripts 1 OS=Homo sapiens OX=9606 GN=UPF1 PE=1 SV=2" "0.000" "False" "92.611" "30" "26" "38" "25" "1129" "124.3" "6.61" "128.69" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09416, Pf13086, Pf13087, Pf18141" "5976" "ENSG00000005007" "UPF1" "hsa:5976; O00239; O43343; Q86Z25; Q92842; Q92900" "Pathophysiological roles of DUX4 in FSHD1" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "3" "0" "1.054" "1.039" "1.058" "1.078" "1.049" "1.010" "0.993" "0.980" "1.029" "3177.7" "3348.8" "3301.2" "3360.7" "3425.8" "3334.9" "3210.3" "3156.9" "3115.5" "3268.3" "" "" "" "" "" "" "" "" "" "" "2977.5" "2771.1" "3064.8" "2598.0" "2920.1" "3186.2" "2933.4" "2803.0" "3115.5" "3146.9" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-885056090803738498" "False" "High" "IsMasterProtein" "P47897" "Glutamine--tRNA ligase OS=Homo sapiens OX=9606 GN=QARS1 PE=1 SV=1" "0.000" "False" "92.427" "40" "27" "38" "26" "775" "87.7" "7.15" "133.32" "27" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf00749, Pf03950, Pf04557, Pf04558, Pf20974" "5859" "ENSG00000172053" "QARS1" "B4DWJ2; hsa:5859; P47897" "" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "3" "0" "0.965" "1.021" "0.994" "1.002" "1.015" "0.969" "0.969" "0.979" "0.986" "4463.8" "4307.2" "4555.8" "4434.8" "4472.5" "4529.3" "4323.3" "4324.4" "4368.1" "4402.5" "" "" "" "" "" "" "" "" "" "" "4182.6" "3564.2" "4229.5" "3428.3" "3812.2" "4327.3" "3950.3" "3839.7" "4368.1" "4239.0" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2064522308959827201" "False" "High" "IsMasterProtein" "Q92841" "Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens OX=9606 GN=DDX17 PE=1 SV=2" "0.000" "False" "92.414" "39" "28" "47" "20" "729" "80.2" "8.27" "148.32" "28" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "10521" "ENSG00000100201" "DDX17" "B1AHM0; H3BLZ8; hsa:10521; Q69YT1; Q6ICD6; Q92841" "Novel intracellular components of RIG-I-like receptor pathway" "SUMOylation of transcription cofactors" "2" "7" "1.011" "1.081" "1.035" "1.083" "1.074" "1.102" "1.187" "1.153" "1.079" "4940.9" "4994.0" "5340.0" "5112.3" "5350.5" "5307.2" "5446.4" "5864.8" "5697.0" "5331.0" "" "" "" "" "" "" "" "" "" "" "4629.6" "4132.5" "4957.5" "3952.0" "4560.6" "5070.6" "4976.6" "5207.3" "5697.0" "5133.0" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3292354779633865334" "False" "High" "IsMasterProtein" "A5YKK6" "CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=2" "0.000" "False" "91.928" "13" "33" "43" "33" "2376" "266.8" "7.11" "128.45" "33" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04054, Pf12842, Pf16415, Pf16417, Pf16418" "23019" "ENSG00000125107" "CNOT1" "A5YKK6; hsa:23019; Q68DX7; Q7Z3K2; Q8IWB8; Q8TB53; Q9BVZ6; Q9UFR8; Q9UI27; Q9Y2L0" "Ciliary landscape" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "4" "0" "0.991" "1.023" "1.027" "1.043" "1.060" "1.018" "1.041" "1.039" "1.038" "4009.4" "3972.4" "4103.5" "4117.5" "4181.7" "4251.6" "4083.5" "4175.1" "4164.1" "4160.5" "" "" "" "" "" "" "" "" "" "" "3756.8" "3287.1" "3809.6" "3183.0" "3564.4" "4062.0" "3731.2" "3707.1" "4164.1" "4006.0" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2214005141303334461" "False" "High" "IsMasterProtein" "P12956" "X-ray repair cross-complementing protein 6 OS=Homo sapiens OX=9606 GN=XRCC6 PE=1 SV=2" "0.000" "False" "91.680" "37" "21" "64" "21" "609" "69.8" "6.64" "205.21" "21" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf02735, Pf03730, Pf03731" "2547" "ENSG00000196419" "XRCC6" "B1AHC8; hsa:2547; P12956; Q6FG89; Q9UCQ2; Q9UCQ3" "Non-homologous end joining; DNA repair pathways, full network; Primary ovarian insufficiency; HDAC6 interactions in the central nervous system" "Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN" "9" "0" "0.943" "1.025" "0.966" "0.963" "0.976" "0.949" "0.995" "0.985" "0.965" "5289.7" "4990.4" "5422.3" "5111.0" "5091.8" "5163.7" "5019.5" "5263.3" "5209.3" "5102.2" "" "" "" "" "" "" "" "" "" "" "4956.4" "4129.5" "5033.9" "3951.1" "4340.1" "4933.5" "4586.5" "4673.3" "5209.3" "4912.7" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3405025144750981774" "False" "High" "IsMasterProtein" "P52732" "Kinesin-like protein KIF11 OS=Homo sapiens OX=9606 GN=KIF11 PE=1 SV=2" "0.000" "False" "91.553" "27" "31" "41" "31" "1056" "119.1" "5.64" "128.20" "31" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf13931" "3832" "ENSG00000138160" "KIF11" "A0AV49; B2RMV3; hsa:3832; P52732; Q15716; Q5VWX0" "" "MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "3" "0" "0.972" "0.986" "0.962" "0.958" "0.951" "0.895" "0.891" "0.893" "0.967" "5759.3" "5598.1" "5680.0" "5543.2" "5519.0" "5479.1" "5153.4" "5130.4" "5145.2" "5569.1" "" "" "" "" "" "" "" "" "" "" "5396.4" "4632.3" "5273.2" "4285.2" "4704.2" "5234.7" "4708.8" "4555.3" "5145.2" "5362.2" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7379954125319751521" "False" "High" "IsMasterProtein" "P48643" "T-complex protein 1 subunit epsilon OS=Homo sapiens OX=9606 GN=CCT5 PE=1 SV=1" "0.000" "False" "91.377" "44" "25" "62" "24" "541" "59.6" "5.66" "188.89" "25" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00118" "22948" "ENSG00000150753" "CCT5" "A8JZY8; A8K2X8; B4DYD8; hsa:22948; P48643" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "7" "0" "0.968" "0.983" "0.961" "0.964" "0.941" "0.927" "0.959" "1.016" "0.966" "6532.1" "6321.3" "6420.1" "6276.0" "6298.0" "6148.7" "6052.4" "6261.7" "6635.3" "6309.3" "" "" "" "" "" "" "" "" "" "" "6120.6" "5230.8" "5960.2" "4851.6" "5368.3" "5874.5" "5530.2" "5559.7" "6635.3" "6074.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "868363632382073498" "False" "High" "IsMasterProtein" "Q6UB35" "Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD1L PE=1 SV=1" "0.000" "False" "91.301" "28" "26" "42" "25" "978" "105.7" "8.06" "133.55" "26" "other metabolic processes;developmental processes" "cytosol;mitochondrion" "other molecular function" "Pf00763, Pf01268, Pf02882" "25902" "ENSG00000120254" "MTHFD1L" "hsa:25902; Q2TBF3; Q6UB35; Q8WVW0; Q96HG8; Q9H789; Q9UFU8" "One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways" "Metabolism of folate and pterines" "3" "0" "1.023" "1.041" "1.038" "1.059" "1.036" "1.020" "1.007" "1.023" "1.047" "3357.9" "3435.2" "3497.2" "3484.6" "3557.6" "3479.0" "3426.1" "3381.9" "3434.1" "3515.6" "" "" "" "" "" "" "" "" "" "" "3146.4" "2842.6" "3246.7" "2693.7" "3032.4" "3323.8" "3130.5" "3002.8" "3434.1" "3385.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3283541064302857350" "False" "High" "IsMasterProtein" "O75533" "Splicing factor 3B subunit 1 OS=Homo sapiens OX=9606 GN=SF3B1 PE=1 SV=3" "0.000" "False" "91.102" "24" "26" "45" "26" "1304" "145.7" "7.09" "143.51" "26" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08920" "23451" "ENSG00000115524" "SF3B1" "E9PCH3; hsa:23451; O75533" "mRNA processing; 10q11.21q11.23 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "5" "0" "0.990" "1.051" "1.021" "1.027" "1.006" "1.100" "1.120" "1.100" "1.046" "4326.7" "4285.4" "4549.3" "4418.2" "4443.5" "4354.7" "4760.4" "4846.2" "4760.0" "4525.9" "" "" "" "" "" "" "" "" "" "" "4054.1" "3546.1" "4223.5" "3415.4" "3787.5" "4160.5" "4349.8" "4303.0" "4760.0" "4357.8" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5988193438521902409" "False" "High" "IsMasterProtein" "P26640" "Valine--tRNA ligase OS=Homo sapiens OX=9606 GN=VARS1 PE=1 SV=4" "0.000" "False" "90.636" "24" "27" "49" "27" "1264" "140.4" "7.59" "161.64" "27" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "other molecular function" "Pf00043, Pf00133, Pf08264" "7407" "ENSG00000096171; ENSG00000204394; ENSG00000224264; ENSG00000226589; ENSG00000231116" "VARS1" "B0V1N1; B4DZ61; hsa:7407; P26640; Q5JQ90; Q96E77; Q9UQM2" "Amino acid metabolism" "Cytosolic tRNA aminoacylation" "2" "0" "0.948" "1.015" "0.969" "0.960" "0.983" "0.919" "0.994" "0.967" "0.938" "4109.6" "3895.9" "4170.5" "3983.7" "3947.1" "4038.2" "3777.1" "4085.3" "3975.9" "3854.9" "" "" "" "" "" "" "" "" "" "" "3850.7" "3223.8" "3871.8" "3079.6" "3364.4" "3858.1" "3451.3" "3627.3" "3975.9" "3711.7" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8485182549121438413" "False" "High" "IsMasterProtein" "O14776" "Transcription elongation regulator 1 OS=Homo sapiens OX=9606 GN=TCERG1 PE=1 SV=2" "0.000" "False" "90.529" "23" "28" "44" "28" "1098" "123.8" "8.65" "135.98" "28" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00397, Pf01846" "10915" "ENSG00000113649" "TCERG1" "hsa:10915; O14776; Q2NKN2; Q59EA1" "" "mRNA Splicing - Major Pathway" "1" "0" "1.034" "0.961" "0.957" "0.983" "0.990" "0.944" "1.030" "1.035" "0.984" "6665.3" "6892.0" "6407.8" "6376.4" "6550.6" "6596.6" "6292.7" "6865.6" "6895.7" "6555.8" "" "" "" "" "" "" "" "" "" "" "6245.4" "5703.1" "5948.8" "4929.2" "5583.6" "6302.4" "5749.8" "6096.0" "6895.7" "6312.3" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2329486021897558917" "False" "High" "IsMasterProtein" "P78347" "General transcription factor II-I OS=Homo sapiens OX=9606 GN=GTF2I PE=1 SV=2" "0.000" "False" "90.011" "28" "25" "43" "25" "998" "112.3" "6.39" "139.96" "25" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02946" "2969" "ENSG00000263001" "GTF2I" "hsa:2969; O14743; O15359; O43546; O43588; O43589; P78347; Q75M85; Q75M86; Q75M87; Q75M88; Q86U51; Q9BSZ4" "B cell receptor signaling pathway; 7q11.23 copy number variation syndrome; Genetic causes of porto-sinusoidal vascular disease" "" "3" "0" "1.005" "1.026" "1.005" "1.018" "1.012" "1.013" "1.007" "1.049" "1.026" "4720.8" "4745.8" "4844.8" "4745.5" "4805.1" "4778.9" "4782.4" "4753.6" "4951.6" "4842.8" "" "" "" "" "" "" "" "" "" "" "4423.3" "3927.1" "4497.8" "3668.5" "4095.7" "4565.7" "4369.8" "4220.7" "4951.6" "4662.9" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2050551167936510610" "False" "High" "IsMasterProtein" "Q01813" "ATP-dependent 6-phosphofructokinase, platelet type OS=Homo sapiens OX=9606 GN=PFKP PE=1 SV=2" "0.000" "False" "89.653" "36" "25" "47" "20" "784" "85.5" "7.55" "145.32" "25" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00365" "5214" "ENSG00000067057" "PFKP" "B3KS15; hsa:5214; Q01813; Q5VSR7; Q5VSR8" "Cori cycle; Clear cell renal cell carcinoma pathways; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis" "6" "3" "1.014" "0.985" "1.010" "0.976" "0.964" "0.949" "0.960" "1.010" "0.981" "4520.3" "4585.5" "4450.9" "4567.6" "4412.6" "4356.2" "4291.7" "4339.0" "4565.1" "4434.0" "" "" "" "" "" "" "" "" "" "" "4235.5" "3794.4" "4132.1" "3531.0" "3761.2" "4161.9" "3921.5" "3852.6" "4565.1" "4269.3" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7382790352375516909" "False" "High" "IsMasterProtein" "Q15393" "Splicing factor 3B subunit 3 OS=Homo sapiens OX=9606 GN=SF3B3 PE=1 SV=4" "0.000" "False" "89.630" "23" "28" "46" "28" "1217" "135.5" "5.26" "151.85" "28" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "23450" "ENSG00000189091" "SF3B3" "hsa:23450; Q15393; Q6NTI8; Q96GC0; Q9BPY2; Q9UFX7; Q9UJ29" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "0.984" "1.037" "1.038" "1.007" "0.988" "1.056" "1.038" "1.048" "1.031" "4432.0" "4362.9" "4597.2" "4599.7" "4462.8" "4379.9" "4680.7" "4600.6" "4646.4" "4568.6" "" "" "" "" "" "" "" "" "" "" "4152.8" "3610.3" "4267.9" "3555.8" "3804.0" "4184.6" "4277.0" "4084.9" "4646.4" "4398.9" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5211801014996619812" "False" "High" "IsMasterProtein" "O43143" "ATP-dependent RNA helicase DHX15 OS=Homo sapiens OX=9606 GN=DHX15 PE=1 SV=2" "0.000" "False" "89.269" "34" "26" "45" "26" "795" "90.9" "7.46" "129.87" "26" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "1665" "ENSG00000109606" "DHX15" "hsa:1665; O43143; Q9NQT7" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.008" "1.009" "1.041" "1.031" "0.999" "1.054" "1.053" "1.057" "1.012" "4397.8" "4435.0" "4437.0" "4577.2" "4534.6" "4394.2" "4636.3" "4629.1" "4648.7" "4451.8" "" "" "" "" "" "" "" "" "" "" "4120.7" "3669.9" "4119.2" "3538.4" "3865.2" "4198.2" "4236.3" "4110.2" "4648.7" "4286.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6973941838255417452" "False" "High" "IsMasterProtein" "P56192" "Methionine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=MARS1 PE=1 SV=2" "0.000" "False" "88.889" "30" "22" "37" "22" "900" "101.1" "6.16" "136.14" "22" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00043, Pf00458, Pf09334, Pf18485, Pf19303" "4141" "ENSG00000166986" "MARS1" "B3KVK7; hsa:4141; P56192; Q14895; Q53H14; Q96A15; Q96BZ0; Q9NSE0" "" "Cytosolic tRNA aminoacylation; Selenoamino acid metabolism" "2" "0" "0.946" "0.967" "1.015" "0.965" "0.942" "0.971" "0.926" "0.928" "0.949" "3763.6" "3561.4" "3640.5" "3821.4" "3633.1" "3545.8" "3654.1" "3484.7" "3490.9" "3572.1" "" "" "" "" "" "" "" "" "" "" "3526.5" "2947.0" "3379.7" "2954.1" "3096.7" "3387.7" "3338.9" "3094.1" "3490.9" "3439.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3038689840563559267" "False" "High" "IsMasterProtein" "Q8WWM7" "Ataxin-2-like protein OS=Homo sapiens OX=9606 GN=ATXN2L PE=1 SV=2" "0.000" "False" "88.754" "28" "26" "37" "25" "1075" "113.3" "8.59" "135.85" "26" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf06741, Pf07145, Pf14438" "11273" "ENSG00000168488" "ATXN2L" "A8K1R6; B9EGM2; E9PAR9; hsa:11273; O95135; Q63ZY4; Q6NVJ8; Q6PJW6; Q8IU61; Q8IU95; Q8WWM3; Q8WWM4; Q8WWM5; Q8WWM6; Q8WWM7; Q99703" "16p11.2 distal deletion syndrome" "" "1" "0" "1.018" "1.008" "1.009" "1.046" "1.030" "1.012" "1.067" "1.027" "1.018" "5487.8" "5585.1" "5530.1" "5538.4" "5740.5" "5651.9" "5556.2" "5853.4" "5634.3" "5588.0" "" "" "" "" "" "" "" "" "" "" "5142.1" "4621.6" "5134.0" "4281.4" "4893.0" "5399.8" "5076.9" "5197.2" "5634.3" "5380.4" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604627173476332081" "False" "High" "IsMasterProtein" "O75534" "Cold shock domain-containing protein E1 OS=Homo sapiens OX=9606 GN=CSDE1 PE=1 SV=2" "0.000" "False" "88.506" "38" "28" "43" "28" "798" "88.8" "6.25" "132.91" "28" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "nucleic acid binding activity" "Pf00313, Pf12901" "7812" "ENSG00000009307" "CSDE1" "A8K281; E9PGZ0; G5E9Q2; hsa:7812; O75534; O94961; Q5TF04; Q5TF05; Q68DF1; Q68DI9; Q9Y2S4" "" "" "0" "0" "0.956" "1.009" "0.979" "0.962" "0.973" "0.915" "0.940" "0.937" "0.971" "5268.5" "5035.9" "5316.9" "5158.8" "5070.9" "5124.7" "4818.1" "4952.9" "4936.9" "5118.0" "" "" "" "" "" "" "" "" "" "" "4936.6" "4167.1" "4936.1" "3988.0" "4322.3" "4896.1" "4402.4" "4397.7" "4936.9" "4927.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8200753479416328933" "False" "High" "IsMasterProtein" "Q8NF50" "Dedicator of cytokinesis protein 8 OS=Homo sapiens OX=9606 GN=DOCK8 PE=1 SV=3" "0.000" "False" "88.387" "15" "33" "40" "32" "2099" "238.4" "6.87" "115.04" "33" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity" "Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "81704" "ENSG00000107099" "DOCK8" "A2A350; A2BDF2; A4FU78; B7ZLP0; E9PH09; hsa:81704; Q3MV16; Q5JPJ1; Q8NF50; Q8TEP1; Q8WUY2; Q9BYJ5; Q9H1Q2; Q9H1Q3; Q9H308; Q9H7P2" "" "Factors involved in megakaryocyte development and platelet production; CDC42 GTPase cycle; RHOJ GTPase cycle; RAC1 GTPase cycle" "4" "1" "1.039" "1.029" "1.068" "1.046" "1.071" "1.030" "1.047" "1.014" "1.074" "3186.3" "3311.7" "3278.7" "3403.7" "3331.6" "3413.2" "3282.6" "3335.2" "3232.1" "3422.3" "" "" "" "" "" "" "" "" "" "" "2985.5" "2740.4" "3043.8" "2631.2" "2839.8" "3261.0" "2999.5" "2961.3" "3232.1" "3295.2" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8835450799000805125" "False" "High" "IsMasterProtein" "Q8N1F7" "Nuclear pore complex protein Nup93 OS=Homo sapiens OX=9606 GN=NUP93 PE=1 SV=2" "0.000" "False" "88.057" "37" "30" "39" "30" "819" "93.4" "5.72" "116.48" "30" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf04097" "9688" "ENSG00000102900" "NUP93" "B3KPQ8; hsa:9688; Q14705; Q8N1F7" "" "ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Early Events; Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "0.981" "1.029" "1.000" "1.037" "1.062" "1.045" "1.065" "1.107" "1.060" "4735.2" "4645.2" "4872.5" "4735.4" "4910.6" "5030.1" "4949.0" "5042.2" "5240.6" "5017.1" "" "" "" "" "" "" "" "" "" "" "4436.9" "3843.8" "4523.5" "3660.7" "4185.7" "4805.7" "4522.0" "4476.9" "5240.6" "4830.7" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7014036665860809700" "False" "High" "IsMasterProtein" "Q13459" "Unconventional myosin-IXb OS=Homo sapiens OX=9606 GN=MYO9B PE=1 SV=3" "0.000" "False" "87.469" "14" "32" "36" "32" "2157" "243.2" "8.75" "105.52" "32" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf00620, Pf00788" "4650" "ENSG00000099331" "MYO9B" "hsa:4650; O75314; Q13459; Q9NUJ2; Q9UHN0" "Vitamin D receptor pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHOA GTPase cycle; RAC1 GTPase cycle; RHOC GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle; RHOF GTPase cycle; SLIT2:ROBO1 increases RHOA activity" "10" "0" "0.967" "0.972" "0.949" "0.964" "0.947" "0.887" "0.879" "0.861" "0.954" "5460.4" "5279.8" "5307.9" "5183.7" "5265.6" "5173.1" "4842.4" "4800.7" "4702.3" "5209.6" "" "" "" "" "" "" "" "" "" "" "5116.4" "4369.0" "4927.7" "4007.2" "4488.3" "4942.4" "4424.7" "4262.6" "4702.3" "5016.1" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1074215629290594570" "False" "High" "IsMasterProtein" "P22626" "Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Homo sapiens OX=9606 GN=HNRNPA2B1 PE=1 SV=2" "0.000" "False" "87.374" "65" "21" "132" "18" "353" "37.4" "8.95" "405.12" "21" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11627" "3181" "ENSG00000122566" "HNRNPA2B1" "A0A024RA27; A0A024RA61; A8K064; hsa:3181; P22626; P22627; Q9UC98; Q9UDJ2" "mRNA processing" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "4" "3" "1.074" "1.035" "1.022" "1.031" "1.025" "0.985" "1.027" "1.090" "1.040" "9548.6" "10253.0" "9879.9" "9761.0" "9839.9" "9782.9" "9401.5" "9804.5" "10410.7" "9934.4" "" "" "" "" "" "" "" "" "" "" "8947.0" "8484.2" "9172.2" "7545.7" "8387.3" "9346.7" "8590.5" "8705.4" "10410.7" "9565.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8217852517475646555" "False" "High" "IsMasterProtein" "Q9H3U1" "Protein unc-45 homolog A OS=Homo sapiens OX=9606 GN=UNC45A PE=1 SV=1" "0.000" "False" "87.137" "30" "28" "37" "28" "944" "103.0" "6.07" "109.22" "28" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf11701, Pf13181" "55898" "ENSG00000140553" "UNC45A" "A8K6F7; hsa:55898; Q7L3Y6; Q9H3U1; Q9H3U8; Q9NSE8; Q9NSE9" "" "" "0" "0" "1.016" "1.009" "1.022" "1.000" "0.981" "0.959" "0.979" "0.988" "1.017" "4575.8" "4648.3" "4616.8" "4678.0" "4576.1" "4490.3" "4388.9" "4478.8" "4519.1" "4655.1" "" "" "" "" "" "" "" "" "" "" "4287.5" "3846.4" "4286.2" "3616.3" "3900.5" "4290.0" "4010.3" "3976.7" "4519.1" "4482.2" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-515522588376759980" "False" "High" "IsMasterProtein" "O60506" "Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens OX=9606 GN=SYNCRIP PE=1 SV=2" "0.000" "False" "86.980" "39" "20" "52" "13" "623" "69.6" "8.59" "155.34" "20" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf18360" "10492" "ENSG00000135316" "SYNCRIP" "E1P501; E1P502; hsa:10492; O60506; Q53H05; Q5TCG2; Q5TCG3; Q8IW78; Q8N599; Q96LC1; Q96LC2; Q9Y583" "" "" "0" "0" "0.964" "0.971" "0.957" "0.959" "0.947" "0.952" "0.962" "1.014" "0.933" "2464.5" "2376.7" "2393.4" "2359.3" "2363.8" "2333.6" "2346.9" "2370.3" "2499.5" "2300.6" "" "" "" "" "" "" "" "" "" "" "2309.3" "1966.7" "2222.0" "1823.8" "2014.8" "2229.5" "2144.4" "2104.6" "2499.5" "2215.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3353104297975983136" "False" "High" "IsMasterProtein" "O43242" "26S proteasome non-ATPase regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PSMD3 PE=1 SV=2" "0.000" "False" "86.724" "45" "24" "55" "24" "534" "60.9" "8.44" "149.15" "24" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01399, Pf08375" "5709" "ENSG00000108344" "PSMD3" "B3KMW9; B4DT72; hsa:5709; O43242; Q96EI2; Q9BQA4" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "0.995" "1.018" "1.004" "1.033" "0.993" "0.985" "1.023" "1.000" "1.009" "4454.9" "4432.1" "4533.3" "4474.6" "4602.5" "4424.3" "4388.6" "4557.1" "4456.1" "4495.7" "" "" "" "" "" "" "" "" "" "" "4174.3" "3667.5" "4208.6" "3459.1" "3923.1" "4227.0" "4010.0" "4046.3" "4456.1" "4328.7" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8321804652329171157" "False" "High" "IsMasterProtein" "Q9BXJ9" "N-alpha-acetyltransferase 15, NatA auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA15 PE=1 SV=1" "0.000" "False" "86.689" "30" "29" "46" "25" "866" "101.2" "7.42" "140.13" "29" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf12569, Pf13181" "80155" "ENSG00000164134" "NAA15" "D3DNY6; Q52LG9; Q8IWH4; Q8NEV2; Q9BXJ9; Q9H8P6" "" "" "0" "3" "0.888" "0.981" "0.935" "0.940" "0.922" "0.909" "0.928" "0.907" "0.935" "7443.2" "6609.0" "7298.3" "6958.1" "6996.4" "6863.2" "6766.6" "6908.7" "6753.3" "6956.5" "" "" "" "" "" "" "" "" "" "" "6974.2" "5468.8" "6775.5" "5378.9" "5963.5" "6557.1" "6182.9" "6134.2" "6753.3" "6698.1" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6674387397432112473" "False" "High" "IsMasterProtein" "P68371" "Tubulin beta-4B chain OS=Homo sapiens OX=9606 GN=TUBB4B PE=1 SV=1" "0.000" "False" "86.652" "49" "18" "95" "1" "445" "49.8" "4.89" "257.41" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00091, Pf03953" "10383" "ENSG00000188229" "TUBB4B" "A2BFA2; hsa:10383; P05217; P68371" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "MHC class II antigen presentation; COPI-mediated anterograde transport; HCMV Early Events; PKR-mediated signaling; Formation of tubulin folding intermediates by CCT/TriC; Prefoldin mediated transfer of substrate to CCT/TriC; Neutrophil degranulation; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Hedgehog 'off' state" "42" "14" "1.006" "0.994" "1.004" "0.979" "0.962" "0.878" "0.887" "1.004" "0.975" "7234.6" "7277.3" "7188.7" "7264.5" "7081.1" "6956.7" "6353.3" "6418.6" "7263.2" "7054.0" "" "" "" "" "" "" "" "" "" "" "6778.8" "6021.9" "6673.8" "5615.8" "6035.8" "6646.4" "5805.2" "5699.1" "7263.2" "6792.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1941852327752543049" "False" "High" "IsMasterProtein" "Q93009" "Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens OX=9606 GN=USP7 PE=1 SV=2" "0.000" "False" "86.570" "26" "27" "45" "27" "1102" "128.2" "5.55" "128.47" "27" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf00917, Pf12436, Pf14533" "7874" "ENSG00000187555" "USP7" "A6NMY8; B7Z815; H0Y3G8; hsa:7874; Q93009" "Nucleotide excision repair in xeroderma pigmentosum ; Warburg effect modulated by deubiquitinating enzymes and their substrates" "Ub-specific processing proteases; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of TP53 Degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Formation of TC-NER Pre-Incision Complex; Regulation of PTEN localization" "10" "0" "0.973" "0.999" "0.987" "0.985" "1.024" "0.973" "1.026" "0.988" "0.999" "5290.3" "5148.8" "5284.9" "5221.7" "5212.4" "5414.8" "5146.9" "5425.8" "5224.5" "5284.2" "" "" "" "" "" "" "" "" "" "" "4957.0" "4260.5" "4906.3" "4036.6" "4442.9" "5173.4" "4702.9" "4817.6" "5224.5" "5088.0" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4912222715256496910" "False" "High" "IsMasterProtein" "O43390" "Heterogeneous nuclear ribonucleoprotein R OS=Homo sapiens OX=9606 GN=HNRNPR PE=1 SV=1" "0.000" "False" "86.564" "37" "20" "44" "13" "633" "70.9" "8.13" "140.33" "20" "RNA metabolism OR transcription;other metabolic processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf18360" "10236" "ENSG00000125944; ENSG00000282958" "HNRNPR" "hsa:10236; O43390; Q2L7G6; Q5TEH1; Q9BV64; S4R3J4" "mRNA processing" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "3" "6" "0.943" "1.035" "0.940" "0.920" "0.935" "0.924" "0.941" "1.007" "0.945" "4459.5" "4204.1" "4617.2" "4192.2" "4103.0" "4171.0" "4119.4" "4197.3" "4491.5" "4215.9" "" "" "" "" "" "" "" "" "" "" "4178.5" "3478.8" "4286.5" "3240.8" "3497.3" "3985.0" "3764.1" "3726.8" "4491.5" "4059.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5449770128653317074" "False" "High" "IsMasterProtein" "Cont_P15636" "Protease 1 OS=Achromobacter lyticus OX=224 PE=1 SV=1" "0.000" "True" "86.476" "20" "14" "143" "14" "653" "68.1" "7.24" "580.26" "14" "protein metabolism" "non-structural extracellular" "other molecular function" "Pf01483, Pf18911" "" "" "" "" "" "" "0" "0" "0.999" "0.990" "1.061" "0.991" "1.129" "0.977" "1.017" "0.981" "1.053" "12175.5" "12161.6" "12050.8" "12920.0" "12071.4" "13741.7" "11896.7" "12382.5" "11941.8" "12821.4" "" "" "" "" "" "" "" "" "" "" "11408.4" "10063.5" "11187.7" "9987.8" "10289.3" "13128.9" "10870.4" "10994.5" "11941.8" "12345.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-256091368978195991" "False" "High" "IsMasterProtein" "Q32MZ4" "Leucine-rich repeat flightless-interacting protein 1 OS=Homo sapiens OX=9606 GN=LRRFIP1 PE=1 SV=2" "0.000" "False" "86.435" "33" "24" "44" "23" "808" "89.2" "4.65" "152.29" "24" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09738" "9208" "ENSG00000124831" "LRRFIP1" "E9PGZ2; hsa:9208; O75766; O75799; Q32MZ4; Q32MZ5; Q53T49; Q6PKG2; Q9Y607" "IL-18 signaling pathway; 2q37 copy number variation syndrome" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production" "5" "1" "1.058" "0.971" "0.960" "0.984" "1.004" "0.992" "1.014" "0.996" "0.990" "6328.1" "6693.2" "6143.9" "6074.3" "6224.4" "6352.7" "6279.8" "6417.1" "6303.5" "6263.6" "" "" "" "" "" "" "" "" "" "" "5929.4" "5538.5" "5703.9" "4695.7" "5305.5" "6069.4" "5738.0" "5697.7" "6303.5" "6030.9" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8676466481375871245" "False" "High" "IsMasterProtein" "P08133" "Annexin A6 OS=Homo sapiens OX=9606 GN=ANXA6 PE=1 SV=3" "0.000" "False" "86.085" "40" "25" "40" "25" "673" "75.8" "5.60" "128.96" "25" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00191" "309" "ENSG00000197043" "ANXA6" "B7Z8A7; D3DQH4; E9PGK1; hsa:309; P08133; Q6ZT79" "Calcium regulation in cardiac cells; Prostaglandin synthesis and regulation" "Smooth Muscle Contraction" "3" "0" "1.043" "1.074" "1.010" "1.061" "1.046" "0.993" "1.029" "0.950" "1.029" "3314.6" "3457.9" "3561.2" "3347.2" "3516.8" "3466.0" "3291.0" "3409.4" "3149.6" "3411.7" "" "" "" "" "" "" "" "" "" "" "3105.8" "2861.4" "3306.1" "2587.5" "2997.6" "3311.5" "3007.1" "3027.2" "3149.6" "3284.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5949671281598126574" "False" "High" "IsMasterProtein" "Q13464" "Rho-associated protein kinase 1 OS=Homo sapiens OX=9606 GN=ROCK1 PE=1 SV=1" "0.000" "False" "85.752" "21" "31" "34" "29" "1354" "158.1" "5.90" "103.07" "31" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08912" "6093" "ENSG00000067900" "ROCK1" "B0YJ91; hsa:6093; Q13464; Q2KHM4; Q59GZ4" "Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Gastrin signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; GDNF signaling; G13 signaling pathway" "RND3 GTPase cycle; RHOBTB1 GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; Neutrophil degranulation; VEGFA-VEGFR2 Pathway; Potential therapeutics for SARS; RHOC GTPase cycle; RHOB GTPase cycle; EPHB-mediated forward signaling; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOH GTPase cycle; Apoptotic cleavage of cellular proteins" "35" "2" "0.952" "0.975" "0.965" "0.991" "0.972" "0.958" "0.977" "0.957" "1.003" "5057.0" "4815.8" "4928.1" "4877.7" "5013.6" "4914.1" "4844.2" "4940.1" "4841.0" "5071.9" "" "" "" "" "" "" "" "" "" "" "4738.4" "3985.0" "4575.2" "3770.7" "4273.5" "4694.9" "4426.3" "4386.3" "4841.0" "4883.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4535556334998408323" "False" "High" "IsMasterProtein" "P49411" "Elongation factor Tu, mitochondrial OS=Homo sapiens OX=9606 GN=TUFM PE=1 SV=3" "0.000" "False" "85.666" "61" "23" "48" "23" "455" "49.8" "7.61" "160.94" "23" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "7284" "ENSG00000178952" "TUFM" "hsa:7284; O15276; P49411" "16p11.2 distal deletion syndrome" "Mitochondrial translation elongation; SARS-CoV-2 modulates autophagy" "3" "0" "0.973" "1.016" "0.947" "0.975" "1.018" "0.924" "0.979" "0.973" "0.995" "4103.1" "3993.5" "4168.9" "3884.8" "4000.8" "4178.0" "3792.5" "4018.6" "3992.0" "4083.2" "" "" "" "" "" "" "" "" "" "" "3844.6" "3304.6" "3870.3" "3003.1" "3410.1" "3991.7" "3465.3" "3568.1" "3992.0" "3931.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8796563562417500540" "False" "High" "IsMasterProtein" "P51532" "Transcription activator BRG1 OS=Homo sapiens OX=9606 GN=SMARCA4 PE=1 SV=2" "0.000" "False" "85.610" "19" "29" "45" "18" "1647" "184.5" "7.88" "129.02" "29" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf14619" "6597" "ENSG00000127616" "SMARCA4" "B1A8Z4; B1A8Z5; B1A8Z6; B1A8Z7; E9PBR8; hsa:6597; O95052; P51532; Q9HBD3" "Androgen receptor network in prostate cancer; Pre-implantation embryo; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Tumor suppressor activity of SMARCB1; Rett syndrome; Thermogenesis; Kleefstra syndrome" "Formation of the beta-catenin:TCF transactivating complex; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Interleukin-7 signaling; RMTs methylate histone arginines; EGR2 and SOX10-mediated initiation of Schwann cell myelination" "13" "6" "0.999" "1.012" "0.957" "0.990" "0.994" "0.915" "0.909" "0.924" "0.997" "4592.4" "4590.0" "4647.3" "4395.7" "4547.8" "4563.9" "4203.1" "4174.9" "4242.1" "4579.7" "" "" "" "" "" "" "" "" "" "" "4303.1" "3798.2" "4314.4" "3398.1" "3876.4" "4360.3" "3840.5" "3706.9" "4242.1" "4409.6" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3930283768056647308" "False" "High" "IsMasterProtein" "P31948" "Stress-induced-phosphoprotein 1 OS=Homo sapiens OX=9606 GN=STIP1 PE=1 SV=1" "0.000" "False" "85.456" "44" "28" "59" "28" "543" "62.6" "6.80" "164.00" "28" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00515, Pf13181, Pf17830" "10963" "ENSG00000168439" "STIP1" "B4DM70; F5H0T1; G3XAD8; hsa:10963; P31948; Q3ZCU9; Q5TZU9" "VEGFA-VEGFR2 signaling" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RND1 GTPase cycle" "3" "0" "1.014" "0.940" "0.862" "0.963" "0.992" "0.947" "0.995" "0.948" "0.940" "7551.4" "7657.0" "7096.1" "6505.6" "7273.5" "7489.8" "7149.0" "7512.0" "7160.2" "7097.1" "" "" "" "" "" "" "" "" "" "" "7075.6" "6336.1" "6587.8" "5029.1" "6199.7" "7155.8" "6532.2" "6669.9" "7160.2" "6833.5" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6576828257658518084" "False" "High" "IsMasterProtein" "Q9BQE3" "Tubulin alpha-1C chain OS=Homo sapiens OX=9606 GN=TUBA1C PE=1 SV=1" "0.000" "False" "85.290" "48" "18" "86" "1" "449" "49.9" "5.10" "283.50" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "84790" "ENSG00000167553" "TUBA1C" "hsa:84790; Q9BQE3" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling; Alzheimer's disease; HDAC6 interactions in the central nervous system" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; HCMV Early Events; Intraflagellar transport; Recycling pathway of L1; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "37" "0" "1.185" "0.954" "1.091" "1.228" "1.002" "1.006" "0.995" "0.963" "1.005" "65.4" "77.5" "62.4" "71.4" "80.4" "65.6" "65.9" "65.1" "63.0" "65.8" "" "" "" "" "" "" "" "" "" "" "61.3" "64.1" "58.0" "55.2" "68.5" "62.6" "60.2" "57.8" "63.0" "63.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7460100142715479081" "False" "High" "IsMasterProtein" "P09960" "Leukotriene A-4 hydrolase OS=Homo sapiens OX=9606 GN=LTA4H PE=1 SV=2" "0.000" "False" "84.615" "44" "24" "56" "24" "611" "69.2" "6.18" "175.63" "24" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01433, Pf09127, Pf17900" "4048" "ENSG00000111144" "LTA4H" "B4DNQ9; F8VV40; hsa:4048; P09960; Q6IAT6; Q9UCT7" "Eicosanoid metabolism via lipooxygenases (LOX); Prostaglandin and leukotriene metabolism in senescence ; Leukotriene metabolic pathway; Prostaglandin and leukotriene metabolism in senescence ; Omega-6-fatty acids in senescence" "Neutrophil degranulation; Biosynthesis of protectins; Synthesis of Leukotrienes (LT) and Eoxins (EX); Biosynthesis of D-series resolvins; Biosynthesis of E-series 18(S)-resolvins; Biosynthesis of aspirin-triggered D-series resolvins; Biosynthesis of E-series 18(R)-resolvins" "12" "0" "0.933" "0.986" "0.947" "0.964" "0.962" "0.946" "0.961" "0.991" "0.942" "5645.9" "5268.4" "5565.6" "5348.2" "5443.7" "5432.9" "5340.3" "5426.3" "5593.7" "5319.1" "" "" "" "" "" "" "" "" "" "" "5290.2" "4359.6" "5166.9" "4134.4" "4640.0" "5190.6" "4879.6" "4818.0" "5593.7" "5121.6" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4342326397945372791" "False" "High" "IsMasterProtein" "O75150" "E3 ubiquitin-protein ligase BRE1B OS=Homo sapiens OX=9606 GN=RNF40 PE=1 SV=5" "0.000" "False" "84.600" "28" "25" "35" "23" "1001" "113.6" "6.29" "121.67" "25" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097" "9810" "ENSG00000103549" "RNF40" "A0A024QZG0; hsa:9810; O75150; Q6AHZ6; Q6N005; Q7L3T6; Q8N615; Q96T18; Q9BSV9; Q9HC82" "ATM signaling in development and disease" "E3 ubiquitin ligases ubiquitinate target proteins" "2" "1" "1.015" "0.982" "1.061" "1.017" "1.015" "1.031" "0.966" "0.987" "1.032" "2145.5" "2177.1" "2106.9" "2276.6" "2182.7" "2176.9" "2211.0" "2072.6" "2117.3" "2213.6" "" "" "" "" "" "" "" "" "" "" "2010.4" "1801.5" "1956.0" "1759.9" "1860.5" "2079.8" "2020.3" "1840.3" "2117.3" "2131.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6011940264998513028" "False" "High" "IsMasterProtein" "O00429" "Dynamin-1-like protein OS=Homo sapiens OX=9606 GN=DNM1L PE=1 SV=2" "0.000" "False" "84.501" "33" "26" "38" "26" "736" "81.8" "6.81" "128.35" "26" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00350, Pf01031, Pf02212" "10059" "ENSG00000087470" "DNM1L" "A8K4X9; B4DGC9; B4DSU8; G8JLD5; hsa:10059; J3KPI2; O00429; O14541; O60709; Q59GN9; Q7L6B3; Q8TBT7; Q9BWM1; Q9Y5J2" "Synaptic vesicle pathway; CAMKK2 pathway" "Apoptotic execution phase" "3" "0" "0.952" "0.983" "0.973" "0.968" "0.948" "0.948" "0.955" "0.944" "0.939" "5585.4" "5315.9" "5490.0" "5434.1" "5408.3" "5293.0" "5297.1" "5333.0" "5270.5" "5243.9" "" "" "" "" "" "" "" "" "" "" "5233.5" "4398.9" "5096.8" "4200.8" "4609.9" "5056.9" "4840.1" "4735.2" "5270.5" "5049.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6718063858029524947" "False" "High" "IsMasterProtein" "P50395" "Rab GDP dissociation inhibitor beta OS=Homo sapiens OX=9606 GN=GDI2 PE=1 SV=2" "0.000" "False" "84.186" "54" "20" "35" "15" "445" "50.6" "6.47" "102.19" "20" "transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "2665" "ENSG00000057608" "GDI2" "hsa:2665; O43928; P50395; Q5SX88; Q9UQM6" "" "RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation" "2" "3" "0.939" "0.967" "0.957" "0.953" "0.940" "0.925" "0.927" "1.031" "0.951" "3539.4" "3324.4" "3422.0" "3385.9" "3371.5" "3326.4" "3272.6" "3280.6" "3649.1" "3365.1" "" "" "" "" "" "" "" "" "" "" "3316.4" "2750.9" "3176.9" "2617.5" "2873.8" "3178.1" "2990.3" "2912.9" "3649.1" "3240.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "627927697280554035" "False" "High" "IsMasterProtein" "O60841" "Eukaryotic translation initiation factor 5B OS=Homo sapiens OX=9606 GN=EIF5B PE=1 SV=4" "0.000" "False" "84.117" "24" "27" "34" "26" "1220" "138.7" "5.49" "115.70" "27" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf11987, Pf14578" "9669" "ENSG00000158417" "EIF5B" "hsa:9669; O60841; O95805; Q53RV7; Q53SI8; Q9UF81; Q9UMN7" "Translation factors; Ciliary landscape" "GTP hydrolysis and joining of the 60S ribosomal subunit" "3" "0" "0.993" "1.044" "1.031" "1.067" "1.038" "1.119" "1.163" "1.094" "1.058" "4534.1" "4501.5" "4732.0" "4675.9" "4838.4" "4705.6" "5073.1" "5272.8" "4960.0" "4795.2" "" "" "" "" "" "" "" "" "" "" "4248.4" "3724.9" "4393.0" "3614.7" "4124.1" "4495.8" "4635.5" "4681.7" "4960.0" "4617.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1866201622056559647" "False" "High" "IsMasterProtein" "Q13263" "Transcription intermediary factor 1-beta OS=Homo sapiens OX=9606 GN=TRIM28 PE=1 SV=5" "0.000" "False" "84.013" "34" "25" "54" "25" "835" "88.5" "5.77" "171.51" "25" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00628, Pf00643, Pf14634" "10155" "ENSG00000130726" "TRIM28" "hsa:10155; O00677; Q13263; Q7Z632; Q93040; Q96IM1" "Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; ATM signaling in development and disease" "HCMV Early Events; SUMOylation of transcription cofactors; Generic Transcription Pathway" "6" "0" "1.009" "0.984" "0.996" "0.997" "0.986" "0.931" "0.935" "0.977" "0.974" "6664.7" "6723.3" "6558.0" "6634.9" "6642.2" "6573.4" "6207.1" "6228.6" "6512.9" "6494.1" "" "" "" "" "" "" "" "" "" "" "6244.8" "5563.5" "6088.3" "5129.0" "5661.6" "6280.3" "5671.6" "5530.4" "6512.9" "6252.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4008936127769007747" "False" "High" "IsMasterProtein" "O43314" "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 OS=Homo sapiens OX=9606 GN=PPIP5K2 PE=1 SV=3" "0.000" "False" "83.879" "22" "27" "33" "21" "1243" "140.3" "8.22" "105.64" "27" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf00328, Pf18086" "23262" "ENSG00000145725" "PPIP5K2" "A1NI53; A6NGS8; hsa:23262; O43314; Q8TB50" "" "Synthesis of pyrophosphates in the cytosol" "1" "6" "0.993" "0.993" "0.997" "0.998" "1.008" "0.899" "0.883" "0.888" "0.984" "4270.2" "4240.6" "4240.8" "4258.5" "4260.4" "4303.5" "3837.4" "3768.8" "3791.6" "4202.0" "" "" "" "" "" "" "" "" "" "" "4001.1" "3509.0" "3937.1" "3292.0" "3631.5" "4111.6" "3506.3" "3346.3" "3791.6" "4045.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8235165147539186554" "False" "High" "IsMasterProtein" "Q16666" "Gamma-interferon-inducible protein 16 OS=Homo sapiens OX=9606 GN=IFI16 PE=1 SV=3" "0.000" "False" "83.841" "37" "24" "59" "22" "785" "88.2" "9.28" "183.70" "24" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02758, Pf02760" "3428" "ENSG00000163565" "IFI16" "A0A346JEQ3; B4DJT8; H3BLV7; hsa:3428; Q16666; Q59GX0; Q5T3W7; Q5T3W8; Q5T3X0; Q5T3X1; Q5T3X2; Q8N9E5; Q8NEQ7; Q96AJ5; Q9UH78" "" "IRF3-mediated induction of type I IFN" "2" "2" "0.983" "1.052" "1.019" "1.012" "1.024" "1.085" "1.032" "1.057" "1.047" "6829.3" "6716.2" "7186.8" "6961.5" "6910.2" "6995.9" "7406.8" "7048.8" "7220.0" "7151.9" "" "" "" "" "" "" "" "" "" "" "6399.0" "5557.6" "6672.1" "5381.6" "5890.1" "6683.9" "6767.9" "6258.6" "7220.0" "6886.3" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "945585302651271031" "False" "High" "IsMasterProtein" "P43243" "Matrin-3 OS=Homo sapiens OX=9606 GN=MATR3 PE=1 SV=2" "0.000" "False" "83.713" "34" "26" "43" "26" "847" "94.6" "6.25" "135.42" "26" "stress response;developmental processes;other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "" "9782" "ENSG00000015479" "MATR3" "B7ZAV5; D3DQC3; hsa:9782; P43243; Q9UHW0; Q9UQ27" "" "" "0" "0" "1.063" "1.102" "1.023" "1.031" "1.023" "1.061" "1.115" "1.172" "1.088" "5629.4" "5983.7" "6203.5" "5756.9" "5801.5" "5759.2" "5973.3" "6279.3" "6595.3" "6125.3" "" "" "" "" "" "" "" "" "" "" "5274.8" "4951.4" "5759.2" "4450.3" "4945.1" "5502.4" "5458.0" "5575.3" "6595.3" "5897.8" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7904029165854268952" "False" "High" "IsMasterProtein" "P62191" "26S proteasome regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMC1 PE=1 SV=1" "0.000" "False" "83.623" "51" "23" "39" "22" "440" "49.2" "6.21" "129.22" "23" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5700" "ENSG00000100764" "PSMC1" "B4DR63; hsa:5700; P49014; P62191; Q03527; Q6IAW0; Q6NW36; Q96AZ3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "64" "0" "0.994" "0.986" "0.960" "0.955" "0.945" "0.906" "0.931" "0.956" "0.926" "4938.9" "4908.9" "4869.7" "4739.0" "4717.6" "4667.4" "4474.6" "4600.3" "4720.5" "4572.7" "" "" "" "" "" "" "" "" "" "" "4627.7" "4062.0" "4520.9" "3663.4" "4021.1" "4459.2" "4088.6" "4084.6" "4720.5" "4402.9" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6656401588938308742" "False" "High" "IsMasterProtein" "Q14676" "Mediator of DNA damage checkpoint protein 1 OS=Homo sapiens OX=9606 GN=MDC1 PE=1 SV=3" "0.000" "False" "83.605" "16" "26" "33" "26" "2089" "226.5" "5.47" "121.46" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00498, Pf16589, Pf16770" "9656" "ENSG00000137337; ENSG00000206481; ENSG00000224587; ENSG00000225589; ENSG00000228575; ENSG00000231135; ENSG00000234012; ENSG00000237095" "MDC1" "A2AB04; A2BF04; A2RRA8; A7YY86; B0S8A2; hsa:9656; Q0EFC2; Q14676; Q2L6H7; Q2TAZ4; Q5JP55; Q5JP56; Q5ST83; Q68CQ3; Q86Z06; Q96QC2" "ATM signaling in development and disease ; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of DNA damage response and repair proteins; TP53 Regulates Transcription of DNA Repair Genes; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "9" "0" "1.041" "1.002" "1.084" "1.076" "1.044" "1.127" "1.132" "1.111" "1.075" "3022.8" "3146.0" "3030.3" "3275.4" "3251.3" "3156.0" "3406.8" "3420.4" "3358.3" "3249.1" "" "" "" "" "" "" "" "" "" "" "2832.3" "2603.3" "2813.2" "2532.0" "2771.3" "3015.3" "3112.9" "3037.0" "3358.3" "3128.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6480137070562712140" "False" "High" "IsMasterProtein" "Cont_Q2KJD0" "Tubulin beta-5 chain OS=Bos taurus OX=9913 GN=TUBB5 PE=2 SV=1" "0.000" "True" "83.484" "45" "17" "95" "2" "444" "49.6" "4.89" "256.13" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "100022562; 100172938; 100303606; 100598146; 100689091; 100718713; 100918219; 100998701; 101034943; 101095657; 101129890; 101318992; 101341456; 101365832; 101593768; 101827904; 101925816; 101965993; 102168953; 102382532; 102506772; 102536943; 102568349; 102831964; 102882060; 102926495; 102963307; 103014346; 103053177; 103080542; 103205965; 103221819; 103261319; 103665004; 104666199; 105074100; 105087494; 105308138; 105498618; 105513957; 105553127; 105600022; 105704569; 105817283; 105855398; 105996956; 106553108; 106825507; 106966617; 107160457; 107498082; 108520633; 108522550; 109249509; 109693530; 203068; 22154; 29214; 396254; 471960; 474830; 574113; 615087; 733686" "ENSACCG00020016918; ENSAMEG00000014418; ENSANAG00000034194; ENSANIG00000003763; ENSAOWG00000004252; ENSBGRG00000008599; ENSBIXG00000008022; ENSBIXG00005015569; ENSBMSG00010013877; ENSBTAG00000006969; ENSCABG00000008181; ENSCAFG00000000443; ENSCAFG00040015599; ENSCAFG00845007927; ENSCANG00000012112; ENSCATG00000014335; ENSCCNG00000028823; ENSCGRG00000007995; ENSCGRG00001023930; ENSCGRG00015028239; ENSCHIG00000025610; ENSCJAG00000048479; ENSCMUG00000016892; ENSCPOG00000035463; ENSCRFG00000007002; ENSCSAG00000008279; ENSCWAG00000006690; ENSEASG00005019680; ENSFCAG00000027444; ENSG00000183311; ENSG00000196230; ENSG00000224156; ENSG00000227739; ENSG00000229684; ENSG00000232421; ENSG00000232575; ENSG00000235067; ENSGAGG00000007027; ENSGGOG00000022655; ENSJJAG00000024145; ENSLCNG00005007041; ENSMFAG00000044340; ENSMICG00000010647; ENSMLEG00000037482; ENSMMMG00000020216; ENSMMNG00015000200; ENSMMNG00015000533; ENSMMNG00015004763; ENSMMSG00000005300; ENSMMUG00000030028; ENSMNEG00000044824; ENSMODG00000023805; ENSMSIG00000015128; ENSMUSG00000001525; ENSNLEG00000005348; ENSOANG00000004061; ENSOARG00000011626; ENSPANG00000015954; ENSPCLG00000013695; ENSPCOG00000022809; ENSPCTG00005009625; ENSPEMG00000025556; ENSPLOG00000016488; ENSPPYG00000016419; ENSPSNG00000012487; ENSPTEG00000030284; ENSPTIG00000006316; ENSPTRG00000017675; ENSRBIG00000034281; ENSRFEG00010000368; ENSRNOG00000061216; ENSRNOG00055006845; ENSRNOG00060003580; ENSRNOG00065029671; ENSRROG00000035442; ENSSBOG00000020987; ENSSDAG00000016166; ENSSHAG00000028751; ENSSHBG00005000940; ENSSOCG00000016453; ENSSSCG00000001379; ENSSSCG00015022877; ENSSSCG00025077784; ENSSSCG00030060370; ENSSSCG00035060189; ENSSSCG00040067819; ENSSSCG00050020383; ENSSSCG00055030461; ENSSSCG00060047808; ENSSSCG00065051381; ENSSSCG00070024618; ENSSSUG00005002289; ENSSTOG00000023492; ENSSVLG00005006345; ENSTGEG00000009306; ENSTGEG00000012139; ENSTGUG00000029087; ENSTSYG00000035292; ENSUAMG00000026276; ENSUMAG00000019678; ENSUPAG00010003937; ENSVURG00010001582; ENSVVUG00000009892; ENSZLMG00000006871" "LOC101341456; LOC106553108; LOC111152509; LOC112622444; LOC114901775; LOC115493080; LOC116436919; TBB7; Tubb; TUBB; Tubb5; TUBB5" "A0A0B8RPP1; A0A0D9R7E7; A0A151MZH9; A0A1S3GEI3; A0A1U7R7I2; A0A1U7SI21; A0A1U7TVN8; A0A1V4L0F2; A0A1W7RC49; A0A218U794; A0A286XDY8; A0A2D4LT52; A0A2D4PSK3; A0A2I3MS98; A0A2J8NXA1; A0A2J8SJF9; A0A2K5EIS8; A0A2K5HGL3; A0A2K5KT86; A0A2K5WBU4; A0A2K5ZFW6; A0A2K6E8N3; A0A2K6G5S3; A0A2K6LAT7; A0A2K6Q336; A0A2K6SLG3; A0A2U3V2D1; A0A2U3WJT7; A0A2Y9EAZ4; A0A2Y9EP82; A0A2Y9HLQ0; A0A2Y9K0M9; A0A2Y9MS78; A0A340WI11; A0A341AY80; A0A384BFD0; A0A384C9R0; A0A387L8L1; A0A3Q7RLV2; A0A3Q7S184; A0A452G3S8; A0A452H2Z1; A0A452SPC5; A0A480TK33; A0A485NK51; A0A4D9DG40; A0A4W2C297; A0A4X2JR93; A0A5E4AVV9; A0A5N3VZ42; A0A5N3WG73; A0A5N4CSN6; A0A663FK44; A0A667GBL5; A0A669QEL9; A0A671DQJ6; A0A672TGM1; A0A673T1T3; A0A674HV74; A0A6B2F8Z8; A0A6B2F9Q6; A0A6I9ILN3; A0A6I9MI92; A0A6I9YS87; A0A6I9ZH14; A0A6J0V952; A0A6J0X5U3; A0A6J1VI28; A0A6J2LA47; A0A6J3H9X1; A0A6P3EF00; A0A6P3RZ49; A0A6P5RBI7; A0A6P6HAZ1; A0A6P7XJA2; A0A6P8P8N4; A0A6P9CC67; A0A6P9FE20; A0A7J7R527; A0A7J7RLA9; A0A7J8GU45; A0A7J8KJ46; A0A7N4PPV2; A0A811YN81; A0A8B7ATI1; A0A8B7EBT6; A0A8B7VFP4; A0A8B9M868; A0A8B9P6J0; A0A8B9X0N8; A0A8C0I1Y2; A0A8C0IPC0; A0A8C0SSP9; A0A8C3VZK5; A0A8C3XAR0; A0A8C4PT60; A0A8C5LKQ9; A0A8C6AUQ3; A0A8C6EXU6; A0A8C6FHM7; A0A8C6MWA3; A0A8C8XQA1; A0A8C9BZ32; A0A8C9I594; A0A8C9J767; A0A8C9USK8; A0A8D0FX24; A0A8D2B3E9; A0A8D2EVN1; A0A8D2GXX0; A0A8D2P6S2; A0A8I3N9K0; A0A8K1G105; A0A8U0NH48; A0A8U7NRV1; A0A9B0X0S4; A0A9F2WGG8; A0A9V1E7C8; A0A9W3GX28; A0A9X9LVU0; A0AA35K0A2; A5D9A3; A6KT85; aju:106966617; amj:102568349; asn:102382532; B1B178; bacu:103014346; bta:615087; caty:105600022; ccan:109693530; cdk:105087494; cfa:474830; cfr:102506772; cge:100689091; chx:102168953; cpoc:100718713; csab:103221819; csyr:103261319; dle:111170669; dord:105996956; F6TYN8; F7F082; fca:101095657; G1LKN6; G1R063; G3HQP8; G3SB76; gga:396254; ggo:101129890; gsh:117346094; hsa:203068; I3ND93; J3S5D8; L5KK71; M3X7Z9; maua:101827904; mcal:110312171; mcc:574113; mdo:100022562; mmu:22154; mmur:105855398; mni:105498618; mpuf:101674529; muo:115466267; nasi:112395403; nle:100598146; nss:113423183; nsu:110586671; oas:100303606; oro:101365832; P05218; P07437; P09244; P69893; P69895; P69897; P99024; pale:102882060; panu:100998701; pbi:103053177; pcad:102979859; pcoq:105817283; pdic:114493854; pgut:117667950; pon:100172938; ptg:102963307; ptr:471960; pvp:105308138; pvt:110090161; Q1XHT6; Q2KJD0; Q3TFB6; Q3THH9; Q3TIL1; Q3UAV4; Q3UF52; Q5R943; Q5SU16; Q5TM69; Q6P9X8; Q767L7; Q7JJU6; Q8WUC1; Q9CY33; ray:107498082; rbb:108520633; rbb:108522550; rno:29214; rro:104666199; S9WJD1; sbq:101034943; shr:100918219; ssc:733686; T1DHR5; tmu:101341456; tsr:106553108; U3FAQ9; U3FM57; umr:103665004; vpc:102536943; vvp:112913571; W5PPT6; zca:113927996" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Opioid receptor pathways; Alzheimer's disease; HDAC6 interactions in the central nervous system" "Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Potential therapeutics for SARS; Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2" "57" "2" "0.976" "0.995" "1.000" "1.001" "1.030" "0.881" "0.845" "0.890" "0.970" "1288.8" "1258.1" "1282.4" "1288.7" "1289.8" "1327.8" "1135.8" "1088.5" "1147.5" "1250.7" "" "" "" "" "" "" "" "" "" "" "1207.6" "1041.0" "1190.6" "996.2" "1099.4" "1268.6" "1037.9" "966.5" "1147.5" "1204.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9171365705039643338" "False" "High" "IsMasterProtein" "P45974" "Ubiquitin carboxyl-terminal hydrolase 5 OS=Homo sapiens OX=9606 GN=USP5 PE=1 SV=2" "0.000" "False" "83.458" "25" "21" "34" "21" "858" "95.7" "5.03" "119.69" "21" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf00443, Pf00627, Pf02148, Pf17807" "8078" "ENSG00000111667" "USP5" "D3DUS7; D3DUS8; hsa:8078; P45974; Q96J22" "IL-18 signaling pathway" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Ub-specific processing proteases" "3" "0" "0.939" "0.998" "0.956" "0.945" "0.966" "0.928" "0.944" "0.937" "0.969" "4706.7" "4417.7" "4699.0" "4501.3" "4449.0" "4544.6" "4369.2" "4445.4" "4409.0" "4559.7" "" "" "" "" "" "" "" "" "" "" "4410.2" "3655.6" "4362.4" "3479.7" "3792.2" "4341.9" "3992.3" "3947.0" "4409.0" "4390.4" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "528371413836643526" "False" "High" "IsMasterProtein" "Q92945" "Far upstream element-binding protein 2 OS=Homo sapiens OX=9606 GN=KHSRP PE=1 SV=4" "0.000" "False" "83.449" "37" "24" "44" "22" "711" "73.1" "7.30" "140.61" "24" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf09005" "8570" "ENSG00000088247" "KHSRP" "hsa:8570; O00301; Q59EZ9; Q5U4P6; Q92945; Q9UNT5; Q9UQH5" "Pre-implantation embryo" "ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA" "3" "1" "1.149" "1.021" "1.046" "1.051" "1.016" "1.019" "1.018" "1.026" "1.016" "2852.8" "3277.9" "2911.7" "2985.4" "2997.6" "2897.4" "2907.0" "2905.1" "2925.8" "2899.5" "" "" "" "" "" "" "" "" "" "" "2673.1" "2712.4" "2703.1" "2307.8" "2555.1" "2768.2" "2656.2" "2579.5" "2925.8" "2791.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5579729439990208910" "False" "High" "IsMasterProtein" "P06733" "Alpha-enolase OS=Homo sapiens OX=9606 GN=ENO1 PE=1 SV=2" "0.000" "False" "83.263" "45" "18" "75" "8" "434" "47.1" "7.39" "235.89" "18" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00113, Pf03952" "2023" "ENSG00000074800" "ENO1" "B2RD59; hsa:2023; P06733; P22712; Q16704; Q4TUS4; Q53FT9; Q53HR3; Q658M5; Q6GMP2; Q71V37; Q7Z3V6; Q8WU71; Q96GV1; Q9BT62; Q9UCH6; Q9UM55" "Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; IL-18 signaling pathway; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism" "9" "6" "0.982" "0.978" "1.029" "0.949" "1.031" "0.923" "0.984" "0.964" "0.952" "6288.2" "6173.4" "6148.8" "6468.8" "5968.3" "6481.3" "5806.6" "6190.1" "6063.4" "5983.7" "" "" "" "" "" "" "" "" "" "" "5892.0" "5108.4" "5708.4" "5000.7" "5087.3" "6192.3" "5305.7" "5496.2" "6063.4" "5761.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602445909866352508" "False" "High" "IsMasterProtein" "P19338" "Nucleolin OS=Homo sapiens OX=9606 GN=NCL PE=1 SV=3" "0.000" "False" "83.160" "33" "27" "55" "27" "710" "76.6" "4.70" "154.91" "27" "developmental processes;other biological processes" "plasma membrane;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "4691" "ENSG00000115053" "NCL" "hsa:4691; P19338; Q53SK1; Q8NB06; Q9UCF0; Q9UDG1" "Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling" "Major pathway of rRNA processing in the nucleolus and cytosol; Respiratory syncytial virus (RSV) attachment and entry" "4" "0" "1.040" "1.086" "0.816" "0.825" "0.766" "1.084" "1.073" "1.070" "0.958" "5984.2" "6225.1" "6498.1" "4884.9" "4936.6" "4581.1" "6484.2" "6419.5" "6403.8" "5730.7" "" "" "" "" "" "" "" "" "" "" "5607.2" "5151.2" "6032.7" "3776.3" "4207.9" "4376.8" "5924.8" "5699.9" "6403.8" "5517.9" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4636491781207187808" "False" "High" "IsMasterProtein" "P14868" "Aspartate--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=DARS1 PE=1 SV=2" "0.000" "False" "83.086" "56" "27" "43" "27" "501" "57.1" "6.55" "136.82" "27" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00152, Pf01336" "1615" "ENSG00000115866" "DARS1" "A8K3J2; D3DP77; hsa:1615; P14868; Q2TNI3; Q32Q69; Q53HV4; Q53YC5; Q68CR9; Q9BW52" "Alanine and aspartate metabolism" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "3" "0" "0.952" "0.976" "0.963" "0.965" "0.951" "0.920" "0.942" "0.950" "0.952" "6133.7" "5836.8" "5985.9" "5907.9" "5918.0" "5833.5" "5643.6" "5776.3" "5827.4" "5837.9" "" "" "" "" "" "" "" "" "" "" "5747.2" "4829.9" "5557.1" "4567.1" "5044.3" "5573.3" "5156.7" "5128.8" "5827.4" "5621.1" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8012908085941337264" "False" "High" "IsMasterProtein" "Q99832" "T-complex protein 1 subunit eta OS=Homo sapiens OX=9606 GN=CCT7 PE=1 SV=2" "0.000" "False" "83.071" "43" "23" "58" "23" "543" "59.3" "7.65" "165.87" "23" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "10574" "ENSG00000135624" "CCT7" "A8K7E6; A8MWI8; B7WNW9; B7Z4T9; B7Z4Z7; hsa:10574; O14871; Q6FI26; Q99832" "VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; RHOBTB1 GTPase cycle; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC" "9" "0" "0.954" "0.963" "0.956" "0.934" "0.941" "0.930" "0.968" "0.980" "0.940" "4922.0" "4693.2" "4741.8" "4706.8" "4594.9" "4631.8" "4576.4" "4765.2" "4823.2" "4626.4" "" "" "" "" "" "" "" "" "" "" "4611.9" "3883.6" "4402.2" "3638.6" "3916.6" "4425.3" "4181.6" "4231.0" "4823.2" "4454.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4397536938893978881" "False" "High" "IsMasterProtein" "O43491" "Band 4.1-like protein 2 OS=Homo sapiens OX=9606 GN=EPB41L2 PE=1 SV=1" "0.000" "False" "82.888" "27" "26" "40" "25" "1005" "112.5" "5.44" "118.21" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" "2037" "ENSG00000079819" "EPB41L2" "B4DHI8; E9PPD9; hsa:2037; O43491; Q5T4F0; Q68DV2" "Splicing factor NOVA regulated synaptic proteins" "Neurexins and neuroligins" "2" "1" "0.982" "1.004" "1.001" "0.996" "0.960" "0.967" "0.995" "0.959" "0.981" "3662.4" "3595.8" "3678.5" "3664.3" "3646.9" "3515.7" "3542.9" "3645.9" "3510.6" "3592.0" "" "" "" "" "" "" "" "" "" "" "3431.7" "2975.4" "3415.0" "2832.7" "3108.5" "3358.9" "3237.3" "3237.2" "3510.6" "3458.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3988284594388072596" "False" "High" "IsMasterProtein" "Q92974" "Rho guanine nucleotide exchange factor 2 OS=Homo sapiens OX=9606 GN=ARHGEF2 PE=1 SV=4" "0.000" "False" "82.822" "28" "26" "34" "26" "986" "111.5" "7.27" "114.88" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00621, Pf17838" "9181" "ENSG00000116584" "ARHGEF2" "D3DVA6; hsa:9181; O75142; Q15079; Q5VY92; Q8TDA3; Q8WUG4; Q92974; Q9H023" "Pathogenic Escherichia coli infection" "RHOA GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle" "5" "0" "1.041" "1.045" "1.056" "1.035" "0.997" "0.975" "0.953" "0.924" "1.015" "3608.1" "3757.6" "3768.9" "3809.0" "3736.1" "3597.2" "3519.2" "3439.8" "3335.3" "3660.9" "" "" "" "" "" "" "" "" "" "" "3380.8" "3109.4" "3499.0" "2944.5" "3184.5" "3436.8" "3215.6" "3054.2" "3335.3" "3524.9" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5299836175419688438" "False" "High" "IsMasterProtein" "P42166" "Lamina-associated polypeptide 2, isoform alpha OS=Homo sapiens OX=9606 GN=TMPO PE=1 SV=2" "0.000" "False" "81.957" "38" "21" "33" "21" "694" "75.4" "7.66" "118.72" "21" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03020, Pf08198, Pf11560" "7112" "ENSG00000120802" "TMPO" "P08918; P08919; P42166; Q14860; Q16295" "Envelope proteins and their potential roles in EDMD physiopathology; Overlap between signal transduction pathways contributing to LMNA laminopathies" "" "2" "0" "1.013" "1.027" "0.966" "1.007" "1.021" "0.979" "1.024" "1.053" "1.014" "2931.7" "2971.1" "3012.2" "2830.6" "2952.6" "2994.7" "2871.2" "3001.0" "3085.9" "2973.0" "" "" "" "" "" "" "" "" "" "" "2747.0" "2458.5" "2796.5" "2188.2" "2516.7" "2861.2" "2623.5" "2664.6" "3085.9" "2862.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1968544072233028588" "False" "High" "IsMasterProtein" "P23246" "Splicing factor, proline- and glutamine-rich OS=Homo sapiens OX=9606 GN=SFPQ PE=1 SV=2" "0.000" "False" "81.819" "30" "20" "75" "19" "707" "76.1" "9.44" "223.26" "20" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08075" "6421" "ENSG00000116560" "SFPQ" "hsa:6421; P23246; P30808; Q5SZ71" "mRNA processing; Type 2 papillary renal cell carcinoma" "Suppression of apoptosis; PTK6 Regulates Proteins Involved in RNA Processing" "4" "0" "0.993" "1.037" "0.982" "1.011" "1.023" "1.047" "1.081" "1.162" "1.039" "5371.2" "5331.7" "5570.8" "5274.2" "5432.2" "5496.0" "5624.7" "5807.8" "6239.9" "5581.5" "" "" "" "" "" "" "" "" "" "" "5032.8" "4411.9" "5171.8" "4077.2" "4630.3" "5250.9" "5139.5" "5156.8" "6239.9" "5374.2" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4230777369959258810" "False" "High" "IsMasterProtein" "O95239" "Chromosome-associated kinesin KIF4A OS=Homo sapiens OX=9606 GN=KIF4A PE=1 SV=3" "0.000" "False" "81.745" "22" "26" "33" "25" "1232" "139.8" "6.27" "111.85" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;transport" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00225" "24137" "ENSG00000090889" "KIF4A" "B2R7V5; D3DVU4; hsa:24137; O95239; Q86TN3; Q86XX7; Q9NNY6; Q9NY24; Q9UMW3" "Retinoblastoma gene in cancer" "Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins" "5" "1" "0.998" "0.986" "1.015" "1.021" "0.984" "0.975" "0.963" "0.972" "1.007" "4173.7" "4165.2" "4113.9" "4237.7" "4260.4" "4105.8" "4071.2" "4021.3" "4056.3" "4203.5" "" "" "" "" "" "" "" "" "" "" "3910.8" "3446.7" "3819.3" "3275.9" "3631.5" "3922.7" "3720.0" "3570.5" "4056.3" "4047.4" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93138434393619496" "False" "High" "IsMasterProtein" "Q9NTI5" "Sister chromatid cohesion protein PDS5 homolog B OS=Homo sapiens OX=9606 GN=PDS5B PE=1 SV=1" "0.000" "False" "81.492" "19" "27" "41" "23" "1447" "164.6" "8.47" "130.26" "27" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf20168" "23047" "ENSG00000083642" "PDS5B" "hsa:23047; Q5R3S3; Q5W0K8; Q6NSC3; Q8IXT6; Q9H5N8; Q9NTI5; Q9Y2I5; Q9Y451" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "6" "0" "0.973" "1.065" "1.027" "1.016" "0.980" "1.010" "1.038" "1.031" "1.039" "3357.8" "3268.4" "3577.6" "3448.5" "3411.2" "3289.1" "3392.1" "3485.0" "3460.4" "3487.6" "" "" "" "" "" "" "" "" "" "" "3146.2" "2704.6" "3321.3" "2665.8" "2907.6" "3142.5" "3099.5" "3094.3" "3460.4" "3358.0" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-291186294764485320" "False" "High" "IsMasterProtein" "P33993" "DNA replication licensing factor MCM7 OS=Homo sapiens OX=9606 GN=MCM7 PE=1 SV=4" "0.000" "False" "81.432" "33" "22" "49" "22" "719" "81.3" "6.46" "176.36" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4176" "ENSG00000166508" "MCM7" "A4D2A1; A4D2A2; E9PGN9; hsa:4176; P33993; Q15076; Q96D34; Q96GL1" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "12" "0" "1.045" "1.033" "1.005" "1.033" "0.998" "0.977" "1.015" "1.044" "1.017" "3158.9" "3302.0" "3261.6" "3173.6" "3262.8" "3152.5" "3085.1" "3206.3" "3296.8" "3212.8" "" "" "" "" "" "" "" "" "" "" "2959.9" "2732.4" "3028.0" "2453.4" "2781.1" "3011.9" "2819.0" "2846.8" "3296.8" "3093.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7017874985935534894" "False" "High" "IsMasterProtein" "P18206" "Vinculin OS=Homo sapiens OX=9606 GN=VCL PE=1 SV=4" "0.000" "False" "80.818" "22" "25" "34" "25" "1134" "123.7" "5.66" "94.15" "25" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01044" "7414" "ENSG00000035403" "VCL" "hsa:7414; P18206; Q16450; Q5SWX2; Q7Z3B8; Q8IXU7" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; VEGFA-VEGFR2 signaling; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Melanoma; Regulation of actin cytoskeleton" "Neutrophil degranulation; Platelet degranulation ; Signaling by BRAF and RAF1 fusions; Signaling by ALK fusions and activated point mutants; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "18" "0" "0.974" "0.989" "0.989" "0.999" "0.998" "0.977" "0.984" "0.990" "1.005" "2278.5" "2220.0" "2252.5" "2252.6" "2275.8" "2273.7" "2226.8" "2241.8" "2255.9" "2290.3" "" "" "" "" "" "" "" "" "" "" "2135.0" "1837.0" "2091.1" "1741.4" "1939.8" "2172.3" "2034.7" "1990.5" "2255.9" "2205.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6444296704773161539" "False" "High" "IsMasterProtein" "Q9NSD9" "Phenylalanine--tRNA ligase beta subunit OS=Homo sapiens OX=9606 GN=FARSB PE=1 SV=3" "0.000" "False" "80.736" "40" "24" "40" "24" "589" "66.1" "6.84" "122.05" "24" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf03483, Pf03484, Pf17759, Pf18262" "10056" "ENSG00000116120" "FARSB" "B4DFM0; hsa:10056; O95708; Q4ZFX1; Q57ZJ5; Q9NSD9; Q9NZZ6" "VEGFA-VEGFR2 signaling; Amino acid metabolism" "Cytosolic tRNA aminoacylation" "3" "0" "0.993" "1.005" "0.979" "0.967" "0.970" "0.955" "0.954" "0.982" "0.982" "4742.9" "4710.5" "4768.6" "4641.5" "4585.4" "4600.7" "4528.4" "4522.7" "4657.5" "4657.4" "" "" "" "" "" "" "" "" "" "" "4444.0" "3897.9" "4427.0" "3588.1" "3908.5" "4395.6" "4137.7" "4015.7" "4657.5" "4484.4" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2260804329009372873" "False" "High" "IsMasterProtein" "Q13045" "Protein flightless-1 homolog OS=Homo sapiens OX=9606 GN=FLII PE=1 SV=2" "0.000" "False" "80.733" "19" "24" "33" "24" "1269" "144.7" "6.05" "106.33" "24" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00560, Pf00626, Pf12799, Pf13855" "2314" "ENSG00000177731; ENSG00000284571" "FLII" "B4DIL0; F5H407; hsa:2314; J3QLG3; Q13045" "VEGFA-VEGFR2 signaling; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "" "2" "0" "1.005" "1.026" "0.972" "0.975" "0.984" "0.957" "0.973" "1.025" "0.996" "6302.9" "6335.2" "6468.3" "6126.7" "6144.8" "6202.3" "6028.8" "6134.5" "6458.3" "6277.0" "" "" "" "" "" "" "" "" "" "" "5905.8" "5242.3" "6005.0" "4736.2" "5237.7" "5925.7" "5508.7" "5446.8" "6458.3" "6043.9" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9169618704545618170" "False" "High" "IsMasterProtein" "P04075" "Fructose-bisphosphate aldolase A OS=Homo sapiens OX=9606 GN=ALDOA PE=1 SV=2" "0.000" "False" "80.531" "52" "22" "77" "17" "364" "39.4" "8.09" "250.27" "22" "cell organization and biogenesis;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00274" "226" "ENSG00000149925" "ALDOA" "B4DXI7; hsa:226; P04075; Q6FH76; Q6FI10; Q96B15; Q9BWD9; Q9UCN2" "VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; 16p11.2 proximal deletion syndrome; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "Neutrophil degranulation; Glycolysis; Gluconeogenesis; Platelet degranulation" "11" "3" "1.018" "0.945" "0.935" "0.921" "0.925" "0.881" "0.950" "1.007" "0.936" "6381.5" "6499.2" "6029.5" "5968.0" "5876.2" "5901.1" "5620.5" "6061.3" "6425.1" "5972.4" "" "" "" "" "" "" "" "" "" "" "5979.5" "5378.0" "5597.6" "4613.5" "5008.7" "5637.9" "5135.6" "5381.9" "6425.1" "5750.6" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4399142244827454415" "False" "High" "IsMasterProtein" "Q8NFD5" "AT-rich interactive domain-containing protein 1B OS=Homo sapiens OX=9606 GN=ARID1B PE=1 SV=3" "0.000" "False" "80.272" "13" "27" "35" "27" "2319" "243.8" "6.90" "106.39" "27" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01388, Pf12031" "57492" "ENSG00000049618" "ARID1B" "hsa:57492; Q5JRD1; Q5VYC4; Q8IZY8; Q8NFD5; Q8TEV0; Q8TF02; Q99491; Q9ULI5" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "6" "0" "1.050" "1.043" "0.991" "1.023" "0.989" "1.000" "1.005" "1.010" "1.037" "3084.9" "3240.4" "3218.3" "3058.7" "3154.6" "3050.0" "3084.6" "3100.9" "3114.8" "3200.2" "" "" "" "" "" "" "" "" "" "" "2890.6" "2681.4" "2987.8" "2364.5" "2688.9" "2914.0" "2818.5" "2753.3" "3114.8" "3081.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4595887854081889880" "False" "High" "IsMasterProtein" "Q99460" "26S proteasome non-ATPase regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PSMD1 PE=1 SV=2" "0.000" "False" "79.844" "29" "22" "35" "22" "953" "105.8" "5.39" "120.00" "22" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf01851, Pf13646, Pf18004, Pf21505" "5707" "ENSG00000173692" "PSMD1" "B8ZZH9; hsa:5707; Q24JU0; Q53TI2; Q6GMU5; Q6P2P4; Q6PJM7; Q6PKG9; Q86VU1; Q8IV79; Q99460" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Downstream TCR signaling; Orc1 removal from chromatin; Assembly of the pre-replicative complex; Separation of Sister Chromatids; Neutrophil degranulation; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Cross-presentation of soluble exogenous antigens (endosomes); Regulation of ornithine decarboxylase (ODC); Somitogenesis" "64" "0" "0.943" "0.963" "0.961" "0.985" "0.977" "0.928" "0.959" "0.967" "0.955" "5057.2" "4769.2" "4872.1" "4861.1" "4982.3" "4941.4" "4695.1" "4850.0" "4888.1" "4830.3" "" "" "" "" "" "" "" "" "" "" "4738.6" "3946.5" "4523.1" "3757.8" "4246.8" "4721.0" "4290.1" "4306.3" "4888.1" "4650.9" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1414691960117410819" "False" "High" "IsMasterProtein" "P33991" "DNA replication licensing factor MCM4 OS=Homo sapiens OX=9606 GN=MCM4 PE=1 SV=5" "0.000" "False" "79.822" "29" "24" "42" "24" "863" "96.5" "6.74" "136.04" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855, Pf21128" "4173" "ENSG00000104738" "MCM4" "hsa:4173; P33991; Q8NEH1; Q99658" "Cell cycle; Gastric cancer network 1; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "12" "0" "0.950" "0.984" "0.906" "0.908" "0.930" "0.926" "0.921" "0.947" "0.927" "5071.6" "4820.1" "4989.3" "4597.0" "4606.5" "4714.8" "4695.8" "4673.2" "4800.7" "4699.7" "" "" "" "" "" "" "" "" "" "" "4752.0" "3988.6" "4632.0" "3553.7" "3926.4" "4504.6" "4290.7" "4149.3" "4800.7" "4525.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8288854614025876019" "False" "High" "IsMasterProtein" "P62258" "14-3-3 protein epsilon OS=Homo sapiens OX=9606 GN=YWHAE PE=1 SV=1" "0.000" "False" "79.734" "69" "18" "90" "15" "255" "29.2" "4.74" "250.28" "18" "stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00244" "7531" "ENSG00000108953; ENSG00000274474" "YWHAE" "B3KY71; D3DTH5; hsa:7531; P29360; P42655; P62258; Q4VJB6; Q53XZ5; Q63631; Q7M4R4" "Cell cycle; Myometrial relaxation and contraction pathways; VEGFA-VEGFR2 signaling; Calcium regulation in cardiac cells; 17p13.3 (YWHAE) copy number variation; Sudden infant death syndrome (SIDS) susceptibility pathways" "RAB GEFs exchange GTP for GDP on RABs; Regulation of HSF1-mediated heat shock response; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; TP53 Regulates Metabolic Genes; Signaling by Hippo; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; HSF1 activation; NADE modulates death signalling; Activation of BAD and translocation to mitochondria" "26" "3" "1.013" "0.961" "0.933" "0.938" "0.946" "0.926" "0.969" "1.109" "0.955" "8040.8" "8141.8" "7725.1" "7499.6" "7540.8" "7602.8" "7448.8" "7789.0" "8919.6" "7679.8" "" "" "" "" "" "" "" "" "" "" "7534.2" "6737.3" "7171.7" "5797.5" "6427.6" "7263.8" "6806.2" "6915.9" "8919.6" "7394.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5783897718523636057" "False" "High" "IsMasterProtein" "O95602" "DNA-directed RNA polymerase I subunit RPA1 OS=Homo sapiens OX=9606 GN=POLR1A PE=1 SV=2" "0.000" "False" "79.591" "19" "27" "31" "26" "1720" "194.7" "7.03" "95.10" "27" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04997, Pf04998, Pf05000" "25885" "ENSG00000068654" "POLR1A" "B7Z7T0; D6W5M0; hsa:25885; O95602; Q0VG05; Q9UEH0; Q9UFT9" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "8" "1" "1.010" "1.018" "1.037" "1.031" "1.014" "1.061" "1.080" "1.074" "1.066" "2867.5" "2895.6" "2918.6" "2972.8" "2957.1" "2908.7" "3043.7" "3097.9" "3079.6" "3056.4" "" "" "" "" "" "" "" "" "" "" "2686.9" "2396.1" "2709.5" "2298.1" "2520.6" "2779.0" "2781.1" "2750.6" "3079.6" "2942.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5119731611670534936" "False" "High" "IsMasterProtein" "O60610" "Protein diaphanous homolog 1 OS=Homo sapiens OX=9606 GN=DIAPH1 PE=1 SV=2" "0.000" "False" "79.535" "20" "27" "44" "27" "1272" "141.3" "5.41" "134.75" "27" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02181, Pf06346, Pf06367, Pf06371" "1729" "ENSG00000131504" "DIAPH1" "A6NF18; B7ZKW2; E9PEZ2; hsa:1729; O60610; Q17RN4; Q59FH8; Q9UC76" "Microtubule cytoskeleton regulation; AGE/RAGE pathway; Focal adhesion; Type 2 papillary renal cell carcinoma; Regulation of actin cytoskeleton; G13 signaling pathway" "RHOC GTPase cycle; RHOA GTPase cycle; RHO GTPases Activate Formins; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; ERBB2 Regulates Cell Motility" "14" "0" "0.955" "0.958" "0.924" "0.932" "0.968" "0.932" "0.925" "0.927" "0.960" "4832.6" "4617.5" "4632.0" "4467.6" "4504.5" "4679.5" "4503.9" "4470.7" "4481.2" "4639.8" "" "" "" "" "" "" "" "" "" "" "4528.1" "3820.9" "4300.2" "3453.7" "3839.5" "4470.8" "4115.4" "3969.5" "4481.2" "4467.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7970699774180839953" "False" "High" "IsMasterProtein" "Q9Y230" "RuvB-like 2 OS=Homo sapiens OX=9606 GN=RUVBL2 PE=1 SV=3" "0.000" "False" "79.481" "47" "18" "40" "18" "463" "51.1" "5.64" "128.62" "18" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06068, Pf17856" "10856" "ENSG00000183207" "RUVBL2" "B3KQ59; E7ETE5; hsa:10856; Q6FIB9; Q6PK27; Q9Y230; Q9Y361" "" "HATs acetylate histones; Telomere Extension By Telomerase" "2" "0" "0.978" "1.014" "0.993" "1.020" "0.998" "0.970" "0.981" "0.994" "1.011" "4026.2" "3935.8" "4080.6" "3998.9" "4107.4" "4017.3" "3904.9" "3950.6" "4003.2" "4068.7" "" "" "" "" "" "" "" "" "" "" "3772.6" "3256.8" "3788.4" "3091.3" "3501.0" "3838.1" "3568.0" "3507.7" "4003.2" "3917.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562319574892213792" "False" "High" "IsMasterProtein" "P04406" "Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens OX=9606 GN=GAPDH PE=1 SV=3" "0.000" "False" "79.315" "55" "16" "86" "16" "335" "36.0" "8.46" "240.17" "16" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00044, Pf02800" "2597" "ENSG00000111640" "GAPDH" "E7EUT4; hsa:2597; P00354; P04406; Q53X65" "Cori cycle; Alzheimer's disease and miRNA effects; HIF1A and PPARG regulation of glycolysis; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; 7q11.23 copy number variation syndrome; Glycolysis in senescence; Alzheimer's disease; Sildenafil treatment; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "Glycolysis; Gluconeogenesis" "16" "0" "1.063" "0.967" "1.011" "0.986" "0.987" "0.969" "0.942" "1.039" "0.972" "6229.5" "6621.0" "6026.5" "6295.9" "6143.3" "6150.5" "6037.5" "5866.3" "6473.7" "6052.0" "" "" "" "" "" "" "" "" "" "" "5837.0" "5478.8" "5594.8" "4867.1" "5236.4" "5876.2" "5516.7" "5208.7" "6473.7" "5827.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3988620745573507049" "False" "High" "IsMasterProtein" "P55786" "Puromycin-sensitive aminopeptidase OS=Homo sapiens OX=9606 GN=NPEPPS PE=1 SV=2" "0.000" "False" "79.225" "28" "25" "41" "25" "919" "103.2" "5.72" "125.14" "25" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "9520" "ENSG00000141279" "NPEPPS" "B7Z463; hsa:9520; P55786; Q6P145; Q9NP16; Q9UEM2" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.969" "0.997" "0.996" "0.989" "0.961" "0.949" "0.968" "1.001" "0.974" "3951.4" "3829.1" "3941.3" "3936.4" "3908.0" "3798.4" "3749.5" "3824.4" "3956.6" "3848.7" "" "" "" "" "" "" "" "" "" "" "3702.4" "3168.6" "3659.0" "3043.0" "3331.1" "3629.0" "3426.0" "3395.7" "3956.6" "3705.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4137218576109141814" "False" "High" "IsMasterProtein" "Q06210" "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 OS=Homo sapiens OX=9606 GN=GFPT1 PE=1 SV=3" "0.000" "False" "79.015" "39" "24" "37" "24" "699" "78.8" "7.11" "116.99" "24" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01380, Pf13522" "2673" "ENSG00000198380" "GFPT1" "hsa:2673; Q06210; Q53QE6; Q9BXF8" "UDP-derived sugars synthesis in fibroblasts" "XBP1(S) activates chaperone genes; Synthesis of UDP-N-acetyl-glucosamine; Defective GFPT1 causes CMSTA1" "4" "0" "0.960" "0.996" "0.969" "0.976" "0.991" "0.936" "0.956" "0.937" "0.971" "3921.2" "3763.4" "3904.2" "3798.1" "3827.0" "3886.4" "3668.4" "3748.0" "3674.1" "3807.1" "" "" "" "" "" "" "" "" "" "" "3674.2" "3114.2" "3624.6" "2936.1" "3262.0" "3713.1" "3352.0" "3327.8" "3674.1" "3665.7" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2262993958771163174" "False" "High" "IsMasterProtein" "P40926" "Malate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=MDH2 PE=1 SV=3" "0.000" "False" "78.554" "62" "18" "43" "18" "338" "35.5" "8.68" "143.30" "18" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "4191" "ENSG00000146701" "MDH2" "A8K414; B2RE78; B4DE44; E9PDB2; O43682; P40926" "Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; 7q11.23 distal copy number variation; TCA cycle (aka Krebs or citric acid cycle)" "Mitochondrial protein degradation; Gluconeogenesis; Citric acid cycle (TCA cycle)" "10" "0" "1.024" "0.987" "0.982" "0.974" "1.007" "0.916" "1.009" "1.003" "0.961" "3397.1" "3479.3" "3354.3" "3337.6" "3308.1" "3420.8" "3112.7" "3429.1" "3407.4" "3264.4" "" "" "" "" "" "" "" "" "" "" "3183.0" "2879.1" "3114.0" "2580.1" "2819.7" "3268.3" "2844.2" "3044.7" "3407.4" "3143.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93919318191628628" "False" "High" "IsMasterProtein" "Q92499" "ATP-dependent RNA helicase DDX1 OS=Homo sapiens OX=9606 GN=DDX1 PE=1 SV=2" "0.000" "False" "77.888" "32" "22" "37" "22" "740" "82.4" "7.23" "116.76" "22" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00622" "1653" "ENSG00000079785" "DDX1" "B4DME8; B4DPN6; hsa:1653; Q92499" "DDX1 as a regulatory component of the Drosha microprocessor; mRNA processing" "tRNA processing in the nucleus" "3" "0" "0.969" "1.030" "0.996" "1.010" "1.057" "1.028" "1.051" "1.050" "1.031" "3806.1" "3687.0" "3920.6" "3789.6" "3845.2" "4023.4" "3913.5" "4001.7" "3995.2" "3925.9" "" "" "" "" "" "" "" "" "" "" "3566.3" "3051.0" "3639.8" "2929.6" "3277.6" "3844.0" "3575.9" "3553.1" "3995.2" "3780.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-985965989456980911" "False" "High" "IsMasterProtein" "Q8TEQ6" "Gem-associated protein 5 OS=Homo sapiens OX=9606 GN=GEMIN5 PE=1 SV=3" "0.000" "False" "77.868" "18" "27" "39" "27" "1508" "168.5" "6.62" "114.58" "27" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf00400, Pf12894, Pf21720" "25929" "ENSG00000082516" "GEMIN5" "Q14CV0; Q8TEQ6; Q8WWV4; Q969W4; Q9H9K3; Q9UFI5" "" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "2" "0" "0.981" "0.988" "1.007" "0.967" "0.992" "0.920" "0.920" "0.921" "0.966" "3883.7" "3809.1" "3838.0" "3909.6" "3754.3" "3853.4" "3572.2" "3572.0" "3575.1" "3749.8" "" "" "" "" "" "" "" "" "" "" "3639.0" "3151.9" "3563.1" "3022.3" "3200.0" "3681.5" "3264.1" "3171.6" "3575.1" "3610.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-165801227635855458" "False" "High" "IsMasterProtein" "Q00839" "Heterogeneous nuclear ribonucleoprotein U OS=Homo sapiens OX=9606 GN=HNRNPU PE=1 SV=6" "0.000" "False" "77.722" "25" "22" "61" "22" "825" "90.5" "6.00" "199.28" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00622, Pf02037, Pf13671" "3192" "ENSG00000153187" "HNRNPU" "hsa:3192; O75507; Q00839; Q8N174; Q96HY9; Q9BQ09" "mRNA processing; lncRNA in canonical Wnt signaling and colorectal cancer" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "4" "0" "1.044" "1.072" "1.058" "1.039" "1.023" "0.989" "1.006" "1.090" "1.058" "3993.1" "4168.0" "4280.2" "4223.0" "4149.2" "4083.8" "3949.2" "4017.0" "4352.0" "4224.8" "" "" "" "" "" "" "" "" "" "" "3741.5" "3448.9" "3973.7" "3264.5" "3536.7" "3901.7" "3608.6" "3566.7" "4352.0" "4067.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6605193621902288169" "False" "High" "IsMasterProtein" "Cont_P35908" "Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2" "0.000" "True" "77.634" "32" "21" "32" "14" "639" "65.4" "8.00" "99.00" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3849" "ENSG00000172867" "KRT2" "hsa:3849; P35908; Q4VAQ2" "" "Formation of the cornified envelope" "2" "2" "0.918" "0.478" "0.816" "0.520" "0.546" "3.044" "0.611" "0.417" "0.953" "2888.4" "2651.2" "1380.5" "2358.0" "1502.8" "1578.0" "8792.7" "1765.0" "1203.3" "2753.7" "" "" "" "" "" "" "" "" "" "" "2706.4" "2193.8" "1281.6" "1822.8" "1280.9" "1507.6" "8034.2" "1567.1" "1203.3" "2651.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7589685267009723312" "False" "High" "IsMasterProtein" "Q9H0D6" "5'-3' exoribonuclease 2 OS=Homo sapiens OX=9606 GN=XRN2 PE=1 SV=1" "0.000" "False" "77.547" "26" "22" "32" "22" "950" "108.5" "7.47" "107.48" "22" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03159, Pf17846" "22803" "ENSG00000088930" "XRN2" "hsa:22803; Q3L8N4; Q6KGZ9; Q9BQL1; Q9H0D6; Q9NTW0; Q9NXS6; Q9UL53" "mRNA processing" "Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis" "3" "0" "1.015" "1.030" "1.075" "1.014" "0.993" "1.106" "1.082" "1.084" "1.015" "3145.9" "3193.1" "3239.2" "3381.6" "3191.4" "3122.8" "3478.8" "3404.6" "3409.9" "3194.1" "" "" "" "" "" "" "" "" "" "" "2947.7" "2642.2" "3007.2" "2614.1" "2720.3" "2983.5" "3178.7" "3022.9" "3409.9" "3075.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1734790582977372175" "False" "High" "IsMasterProtein" "P54136" "Arginine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=RARS1 PE=1 SV=2" "0.000" "False" "77.351" "37" "25" "32" "25" "660" "75.3" "6.68" "103.28" "25" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00750, Pf03485, Pf05746" "5917" "ENSG00000113643" "RARS1" "B2RBS9; hsa:5917; P54136; Q53GY4; Q9BWA1" "Amino acid metabolism" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "3" "0" "0.983" "1.018" "1.009" "1.025" "1.005" "0.981" "1.026" "1.030" "1.007" "3998.5" "3932.2" "4069.7" "4035.1" "4098.9" "4017.9" "3923.6" "4103.6" "4117.7" "4027.0" "" "" "" "" "" "" "" "" "" "" "3746.6" "3253.9" "3778.2" "3119.3" "3493.8" "3838.8" "3585.1" "3643.5" "4117.7" "3877.4" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4862457629609710254" "False" "High" "IsMasterProtein" "Q5SW79" "Centrosomal protein of 170 kDa OS=Homo sapiens OX=9606 GN=CEP170 PE=1 SV=1" "0.000" "False" "77.302" "16" "24" "33" "24" "1584" "175.2" "7.11" "109.46" "24" "" "cytosol;cytoskeleton;other cell component" "" "Pf00498, Pf15308" "9859" "ENSG00000143702; ENSG00000276725" "CEP170" "hsa:9859; O75058; Q5SW77; Q5SW78; Q5SW79; Q7LGA9; Q86W31; Q9UQ08; Q9UQ09" "Ciliary landscape" "" "1" "0" "1.069" "1.037" "1.009" "1.022" "0.990" "1.105" "1.055" "1.097" "1.045" "3058.7" "3268.8" "3171.4" "3085.1" "3126.0" "3028.4" "3378.6" "3227.3" "3356.8" "3197.0" "" "" "" "" "" "" "" "" "" "" "2866.0" "2704.9" "2944.3" "2384.9" "2664.5" "2893.3" "3087.2" "2865.5" "3356.8" "3078.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3959572878681588940" "False" "High" "IsMasterProtein" "P17987" "T-complex protein 1 subunit alpha OS=Homo sapiens OX=9606 GN=TCP1 PE=1 SV=1" "0.000" "False" "77.218" "38" "18" "31" "18" "556" "60.3" "6.11" "111.74" "18" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00118" "6950" "ENSG00000120438" "TCP1" "E1P5B2; hsa:6950; P17987; Q15556; Q5TCM3" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "8" "0" "1.026" "1.006" "1.032" "1.027" "0.998" "0.999" "0.994" "1.054" "0.984" "3084.3" "3165.0" "3103.3" "3181.8" "3167.6" "3077.6" "3079.9" "3065.2" "3250.8" "3033.9" "" "" "" "" "" "" "" "" "" "" "2890.0" "2619.0" "2881.0" "2459.7" "2700.0" "2940.4" "2814.2" "2721.6" "3250.8" "2921.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3877327812570757942" "False" "High" "IsMasterProtein" "P50570" "Dynamin-2 OS=Homo sapiens OX=9606 GN=DNM2 PE=1 SV=2" "0.000" "False" "77.207" "30" "26" "41" "26" "870" "98.0" "7.44" "120.39" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00350, Pf01031, Pf02212" "1785" "ENSG00000079805" "DNM2" "A8K1B6; E7EV30; E9PEQ4; hsa:1785; K7ESI9; P50570; Q5I0Y0; Q7Z5S3; Q9UPH4" "Synaptic vesicle pathway; Fragile X syndrome; Intracellular trafficking proteins involved in CMT neuropathy" "Clathrin-mediated endocytosis; Recycling pathway of L1; MHC class II antigen presentation; Lysosome Vesicle Biogenesis; NGF-stimulated transcription; Golgi Associated Vesicle Biogenesis; Toll Like Receptor 4 (TLR4) Cascade; NOSTRIN mediated eNOS trafficking; Retrograde neurotrophin signalling; Formation of annular gap junctions" "14" "0" "1.015" "1.028" "1.011" "1.036" "1.030" "0.977" "0.989" "0.990" "1.009" "3420.5" "3471.9" "3516.6" "3459.7" "3544.0" "3523.7" "3342.5" "3384.2" "3387.4" "3450.3" "" "" "" "" "" "" "" "" "" "" "3205.0" "2873.0" "3264.7" "2674.5" "3020.8" "3366.6" "3054.1" "3004.8" "3387.4" "3322.2" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5341813448089902722" "False" "High" "IsMasterProtein" "P16885" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 OS=Homo sapiens OX=9606 GN=PLCG2 PE=1 SV=4" "0.000" "False" "77.138" "21" "28" "43" "28" "1265" "147.8" "6.64" "120.33" "28" "cell-cell signaling;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00017, Pf00018, Pf00168, Pf00387, Pf00388, Pf16457" "5336" "ENSG00000197943" "PLCG2" "D3DUL3; hsa:5336; P16885; Q3ZTS2; Q59H45; Q969T5" "Leptin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; Microglia pathogen phagocytosis pathway; GPR40 pathway; Ras signaling; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; EGFR tyrosine kinase inhibitor resistance; GDNF signaling; 2q13 copy number variation syndrome; ErbB signaling pathway" "Generation of second messenger molecules; Role of phospholipids in phagocytosis; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; CLEC7A (Dectin-1) signaling; Toll Like Receptor 4 (TLR4) Cascade; GPVI-mediated activation cascade; DAP12 signaling; Synthesis of IP3 and IP4 in the cytosol; Signaling by CSF1 (M-CSF) in myeloid cells; Erythropoietin activates Phospholipase C gamma (PLCG); Dectin-2 family" "30" "0" "0.988" "0.996" "0.938" "0.969" "0.965" "0.900" "0.944" "0.966" "0.995" "5412.6" "5346.2" "5391.9" "5076.3" "5244.1" "5225.6" "4872.4" "5110.4" "5231.2" "5383.2" "" "" "" "" "" "" "" "" "" "" "5071.5" "4423.9" "5005.7" "3924.2" "4469.9" "4992.6" "4452.0" "4537.5" "5231.2" "5183.3" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1936662048644361405" "False" "High" "IsMasterProtein" "P55060" "Exportin-2 OS=Homo sapiens OX=9606 GN=CSE1L PE=1 SV=3" "0.000" "False" "76.981" "28" "25" "37" "25" "971" "110.3" "5.77" "114.85" "25" "transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf03378, Pf03810, Pf08506" "1434" "ENSG00000124207" "CSE1L" "A3RLL6; B2R5T4; E1P5Y0; F8W904; hsa:1434; O75432; P55060; Q32M40; Q9H5B7; Q9NTS0; Q9UP98; Q9UP99; Q9UPA0" "" "" "0" "0" "1.013" "1.016" "1.028" "1.015" "1.004" "1.024" "0.998" "1.053" "1.015" "3816.2" "3867.7" "3877.5" "3922.8" "3873.2" "3831.9" "3906.8" "3808.3" "4016.7" "3873.6" "" "" "" "" "" "" "" "" "" "" "3575.8" "3200.4" "3599.8" "3032.5" "3301.4" "3661.0" "3569.7" "3381.4" "4016.7" "3729.7" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7978508680545557598" "False" "High" "IsMasterProtein" "Q1KMD3" "Heterogeneous nuclear ribonucleoprotein U-like protein 2 OS=Homo sapiens OX=9606 GN=HNRNPUL2 PE=1 SV=1" "0.000" "False" "76.869" "32" "20" "34" "20" "747" "85.1" "4.91" "108.25" "20" "" "nucleus;other cell component" "" "Pf00622, Pf02037, Pf13671" "221092" "ENSG00000214753" "HNRNPUL2" "hsa:221092; Q1KMD3; Q8N3B3" "" "" "0" "0" "0.966" "1.071" "0.914" "0.928" "0.933" "0.913" "0.882" "0.906" "0.962" "3904.2" "3772.2" "4181.6" "3568.6" "3621.6" "3640.9" "3566.2" "3443.3" "3537.8" "3756.3" "" "" "" "" "" "" "" "" "" "" "3658.2" "3121.4" "3882.1" "2758.7" "3087.0" "3478.6" "3258.6" "3057.3" "3537.8" "3616.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2128989799875943394" "False" "High" "IsMasterProtein" "Q92888" "Rho guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=ARHGEF1 PE=1 SV=2" "0.000" "False" "76.587" "28" "24" "30" "24" "912" "102.4" "5.66" "93.15" "24" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf00621, Pf09128, Pf17838" "9138" "ENSG00000076928" "ARHGEF1" "hsa:9138; O00513; Q6NX52; Q8N4J4; Q92888; Q96BF4; Q96F17; Q9BSB1" "G protein signaling pathways; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "9" "0" "1.005" "1.018" "1.028" "0.999" "0.973" "0.974" "0.956" "0.955" "0.993" "4067.1" "4086.1" "4139.1" "4179.2" "4062.4" "3958.3" "3961.3" "3886.2" "3885.7" "4038.3" "" "" "" "" "" "" "" "" "" "" "3810.8" "3381.2" "3842.6" "3230.7" "3462.7" "3781.8" "3619.6" "3450.6" "3885.7" "3888.3" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-915816600694735360" "False" "High" "IsMasterProtein" "O14980" "Exportin-1 OS=Homo sapiens OX=9606 GN=XPO1 PE=1 SV=1" "0.000" "False" "76.529" "24" "24" "47" "24" "1071" "123.3" "6.06" "144.18" "24" "other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf08767, Pf18777, Pf18784, Pf18787" "7514" "ENSG00000082898" "XPO1" "A6NL14; A8K1K5; D6W5E2; hsa:7514; O14980; Q63HP8; Q68CP3; Q99433" "eIF5A regulation in response to inhibition of the nuclear export system; 22q11.2 copy number variation syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; MAPK6/MAPK4 signaling; NPAS4 regulates expression of target genes; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Heme signaling; Deactivation of the beta-catenin transactivating complex; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Downregulation of TGF-beta receptor signaling; HuR (ELAVL1) binds and stabilizes mRNA; Cyclin A/B1/B2 associated events during G2/M transition; Maturation of hRSV A proteins" "19" "0" "0.968" "1.015" "0.975" "0.994" "1.004" "1.021" "0.989" "1.038" "0.995" "3751.6" "3633.0" "3806.6" "3659.2" "3730.2" "3768.0" "3828.9" "3711.4" "3892.7" "3734.4" "" "" "" "" "" "" "" "" "" "" "3515.2" "3006.3" "3534.0" "2828.7" "3179.5" "3599.9" "3498.6" "3295.3" "3892.7" "3595.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2586862151232699530" "False" "High" "IsMasterProtein" "P07237" "Protein disulfide-isomerase OS=Homo sapiens OX=9606 GN=P4HB PE=1 SV=3" "0.000" "False" "76.298" "43" "24" "47" "24" "508" "57.1" "4.87" "145.14" "24" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00085, Pf13848" "5034" "ENSG00000185624" "P4HB" "B2RDQ2; hsa:5034; P07237; P30037; P32079; Q15205; Q6LDE5" "VEGFA-VEGFR2 signaling; Type I collagen synthesis in the context of osteogenesis imperfecta" "Hedgehog ligand biogenesis; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Chylomicron assembly; VLDL assembly; LDL remodeling; Collagen biosynthesis and modifying enzymes; Detoxification of Reactive Oxygen Species; Insulin processing; Interleukin-12 signaling; Interleukin-23 signaling" "13" "0" "0.970" "0.969" "0.932" "0.931" "0.970" "0.913" "0.989" "0.939" "0.930" "4938.9" "4792.9" "4785.3" "4602.7" "4598.6" "4793.2" "4509.9" "4887.0" "4638.9" "4593.8" "" "" "" "" "" "" "" "" "" "" "4627.8" "3966.1" "4442.5" "3558.1" "3919.7" "4579.4" "4120.8" "4339.2" "4638.9" "4423.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5982542769367786087" "False" "High" "IsMasterProtein" "O75116" "Rho-associated protein kinase 2 OS=Homo sapiens OX=9606 GN=ROCK2 PE=1 SV=4" "0.000" "False" "76.275" "17" "25" "30" "23" "1388" "160.8" "6.02" "86.94" "25" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08912" "9475" "ENSG00000134318" "ROCK2" "hsa:9475; O75116; Q53QZ0; Q53SJ7; Q9UQN5" "Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Pathogenic Escherichia coli infection; Spinal cord injury; Focal adhesion; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Wnt signaling; Airway smooth muscle cell contraction; Regulation of actin cytoskeleton; GDNF signaling; G13 signaling pathway" "Potential therapeutics for SARS; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle" "27" "0" "0.986" "0.979" "0.984" "0.971" "0.998" "0.974" "0.957" "0.974" "1.003" "2821.1" "2782.1" "2762.9" "2776.1" "2740.0" "2816.7" "2748.0" "2700.1" "2747.3" "2828.8" "" "" "" "" "" "" "" "" "" "" "2643.3" "2302.2" "2565.0" "2146.0" "2335.5" "2691.1" "2511.0" "2397.4" "2747.3" "2723.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6560846777174153588" "False" "High" "IsMasterProtein" "P53621" "Coatomer subunit alpha OS=Homo sapiens OX=9606 GN=COPA PE=1 SV=2" "0.000" "False" "76.057" "21" "27" "40" "27" "1224" "138.3" "7.66" "121.29" "27" "transport;signal transduction" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00400, Pf04053, Pf06957" "1314" "ENSG00000122218" "COPA" "hsa:1314; P53621; Q5T201; Q8IXZ9" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "0.941" "1.003" "0.940" "0.969" "0.956" "0.925" "0.924" "0.926" "0.948" "5000.0" "4704.3" "5017.3" "4697.9" "4844.3" "4780.0" "4625.7" "4621.7" "4629.8" "4739.6" "" "" "" "" "" "" "" "" "" "" "4685.0" "3892.8" "4657.9" "3631.7" "4129.2" "4566.8" "4226.7" "4103.6" "4629.8" "4563.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "361994698644895597" "False" "High" "IsMasterProtein" "P07355" "Annexin A2 OS=Homo sapiens OX=9606 GN=ANXA2 PE=1 SV=2" "0.000" "False" "76.036" "55" "18" "31" "18" "339" "38.6" "7.75" "111.96" "18" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00191" "302" "ENSG00000182718" "ANXA2" "hsa:302; P07355; Q567R4; Q6N0B3; Q8TBV2; Q96DD5; Q9UDH8" "Gastrin signaling pathway; CCL18 signaling pathway; Prostaglandin synthesis and regulation" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Smooth Muscle Contraction; Dissolution of Fibrin Clot" "7" "0" "0.948" "1.026" "0.912" "1.004" "1.024" "0.963" "1.038" "1.025" "0.986" "3381.0" "3205.5" "3469.6" "3083.9" "3395.3" "3463.2" "3257.5" "3510.9" "3466.3" "3333.8" "" "" "" "" "" "" "" "" "" "" "3167.9" "2652.5" "3221.1" "2384.0" "2894.0" "3308.8" "2976.5" "3117.4" "3466.3" "3210.0" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-45443448741042807" "False" "High" "IsMasterProtein" "P24928" "DNA-directed RNA polymerase II subunit RPB1 OS=Homo sapiens OX=9606 GN=POLR2A PE=1 SV=2" "0.000" "False" "75.724" "15" "28" "35" "28" "1970" "217.0" "7.37" "98.76" "28" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04990, Pf04992, Pf04997, Pf04998, Pf05000, Pf05001" "5430" "" "POLR2A" "A6NN93; B9EH88; hsa:5430; P24928; Q6NX41" "Pyrimidine metabolism; Eukaryotic transcription initiation; mRNA processing" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "44" "0" "0.984" "1.028" "1.008" "0.984" "0.975" "0.993" "0.966" "0.959" "0.983" "3020.1" "2973.2" "3104.6" "3045.7" "2971.7" "2943.8" "2998.1" "2918.7" "2894.9" "2968.3" "" "" "" "" "" "" "" "" "" "" "2829.9" "2460.2" "2882.3" "2354.5" "2533.0" "2812.5" "2739.4" "2591.5" "2894.9" "2858.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8484028389043526679" "False" "High" "IsMasterProtein" "P13010" "X-ray repair cross-complementing protein 5 OS=Homo sapiens OX=9606 GN=XRCC5 PE=1 SV=3" "0.000" "False" "75.504" "29" "21" "33" "21" "732" "82.7" "5.81" "111.19" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf02735, Pf03730, Pf03731, Pf08785" "7520" "ENSG00000079246" "XRCC5" "A8K3X5; hsa:7520; P13010; Q0Z7V0; Q4VBQ5; Q53HH7; Q7M4N0; Q9UCQ0; Q9UCQ1" "Non-homologous end joining; Male infertility; DNA repair pathways, full network; p53 transcriptional gene network" "Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN" "9" "0" "1.013" "1.048" "0.982" "1.026" "0.987" "0.990" "0.998" "1.063" "1.003" "4857.7" "4922.3" "5092.1" "4770.1" "4986.4" "4794.1" "4807.0" "4847.2" "5164.3" "4871.1" "" "" "" "" "" "" "" "" "" "" "4551.6" "4073.2" "4727.4" "3687.5" "4250.2" "4580.3" "4392.3" "4303.8" "5164.3" "4690.1" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7263541365096533312" "False" "High" "IsMasterProtein" "Q13435" "Splicing factor 3B subunit 2 OS=Homo sapiens OX=9606 GN=SF3B2 PE=1 SV=2" "0.000" "False" "75.438" "27" "24" "33" "24" "895" "100.2" "5.67" "109.87" "24" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02037, Pf04037, Pf04046" "10992" "ENSG00000087365" "SF3B2" "A8K485; B4DT19; hsa:10992; Q13435; Q7L4T5; Q7Z627; Q969K1; Q96CM6; Q9BWD2" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "1.019" "1.023" "1.012" "1.014" "0.985" "1.128" "1.111" "1.091" "1.022" "3659.7" "3730.7" "3744.6" "3703.1" "3710.9" "3604.2" "4129.7" "4066.7" "3992.3" "3739.9" "" "" "" "" "" "" "" "" "" "" "3429.1" "3087.1" "3476.4" "2862.7" "3163.1" "3443.5" "3773.4" "3610.9" "3992.3" "3601.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3936589147855356359" "False" "High" "IsMasterProtein" "P54886" "Delta-1-pyrroline-5-carboxylate synthase OS=Homo sapiens OX=9606 GN=ALDH18A1 PE=1 SV=2" "0.000" "False" "75.349" "27" "21" "38" "21" "795" "87.2" "7.12" "121.10" "21" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf00171, Pf00696" "5832" "ENSG00000059573" "ALDH18A1" "B2R5Q4; B7Z350; B7Z5X8; B7ZLP1; D3DR44; hsa:5832; O95952; P54886; Q3KQU2; Q5T566; Q5T567; Q9UM72" "Amino acid metabolism" "Mitochondrial protein degradation" "2" "0" "1.039" "1.031" "1.044" "1.053" "1.053" "1.049" "1.043" "1.040" "1.022" "4157.0" "4318.7" "4286.7" "4339.5" "4376.5" "4377.2" "4360.3" "4337.2" "4325.0" "4248.7" "" "" "" "" "" "" "" "" "" "" "3895.1" "3573.6" "3979.6" "3354.6" "3730.4" "4182.0" "3984.1" "3851.0" "4325.0" "4090.9" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5868182849043771837" "False" "High" "IsMasterProtein" "Q15084" "Protein disulfide-isomerase A6 OS=Homo sapiens OX=9606 GN=PDIA6 PE=1 SV=1" "0.000" "False" "75.258" "39" "14" "41" "14" "440" "48.1" "5.08" "146.83" "14" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00085" "10130" "ENSG00000143870" "PDIA6" "B3KY95; B5MCQ5; B7Z254; B7Z4M8; F8WA83; hsa:10130; Q15084; Q53RC7; Q6ZSH5; Q99778" "Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes" "5" "0" "1.014" "0.991" "1.106" "1.019" "1.030" "1.013" "1.000" "0.978" "1.014" "3315.3" "3362.4" "3285.2" "3666.0" "3379.6" "3415.7" "3359.4" "3314.7" "3243.8" "3361.1" "" "" "" "" "" "" "" "" "" "" "3106.4" "2782.3" "3049.9" "2834.0" "2880.7" "3263.3" "3069.6" "2943.1" "3243.8" "3236.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6735907081845110604" "False" "High" "IsMasterProtein" "Q9Y2L1" "Exosome complex exonuclease RRP44 OS=Homo sapiens OX=9606 GN=DIS3 PE=1 SV=2" "0.000" "False" "75.254" "24" "22" "29" "22" "958" "108.9" "7.14" "97.07" "22" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00773, Pf13638, Pf17215, Pf17216, Pf17849" "22894" "ENSG00000083520" "DIS3" "A6NI21; B2RBL2; hsa:22894; Q5W0P7; Q5W0P8; Q658Z7; Q7Z481; Q8WWI2; Q9UG36; Q9Y2L1" "" "ATF4 activates genes in response to endoplasmic reticulum stress; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; Major pathway of rRNA processing in the nucleolus and cytosol; KSRP (KHSRP) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "0.961" "0.983" "0.973" "0.986" "0.980" "0.983" "0.963" "1.005" "0.998" "3381.9" "3249.6" "3322.9" "3291.1" "3334.6" "3315.2" "3325.7" "3256.3" "3398.9" "3373.5" "" "" "" "" "" "" "" "" "" "" "3168.9" "2689.0" "3084.9" "2544.2" "2842.3" "3167.4" "3038.8" "2891.2" "3398.9" "3248.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4501130865097894528" "False" "High" "IsMasterProtein" "O60763" "General vesicular transport factor p115 OS=Homo sapiens OX=9606 GN=USO1 PE=1 SV=2" "0.000" "False" "75.119" "27" "23" "32" "23" "962" "107.8" "4.91" "113.33" "23" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "" "Pf04869, Pf04871, Pf18770" "8615" "ENSG00000138768" "USO1" "B2RAQ0; hsa:8615; O60763; Q6PK63; Q86TB8; Q8N592" "" "COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization" "3" "0" "0.977" "0.992" "0.971" "0.998" "0.990" "0.971" "0.973" "0.966" "0.991" "3893.9" "3803.4" "3862.9" "3781.4" "3887.4" "3856.1" "3780.0" "3787.5" "3761.1" "3860.7" "" "" "" "" "" "" "" "" "" "" "3648.5" "3147.3" "3586.2" "2923.2" "3313.6" "3684.2" "3453.9" "3362.9" "3761.1" "3717.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1547781430018805415" "False" "High" "IsMasterProtein" "P30101" "Protein disulfide-isomerase A3 OS=Homo sapiens OX=9606 GN=PDIA3 PE=1 SV=4" "0.000" "False" "74.888" "38" "18" "45" "18" "505" "56.7" "6.35" "147.89" "18" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00085, Pf13848" "2923" "ENSG00000167004" "PDIA3" "hsa:2923; P30101; Q13453; Q14255; Q8IYF8; Q9UMU7" "Prion disease pathway" "ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle" "4" "0" "1.038" "1.022" "0.925" "0.997" "1.035" "0.894" "1.024" "1.048" "1.020" "4077.3" "4230.8" "4166.2" "3769.8" "4066.3" "4221.5" "3644.6" "4173.5" "4273.6" "4157.5" "" "" "" "" "" "" "" "" "" "" "3820.4" "3500.9" "3867.8" "2914.3" "3466.0" "4033.3" "3330.2" "3705.7" "4273.6" "4003.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2749950876556130584" "False" "High" "IsMasterProtein" "P0DMV9" "Heat shock 70 kDa protein 1B OS=Homo sapiens OX=9606 GN=HSPA1B PE=1 SV=1" "0.000" "False" "74.811" "32" "20" "54" "11" "641" "70.0" "5.66" "174.16" "20" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00012" "3303; 3304" "ENSG00000204388; ENSG00000212866; ENSG00000224501; ENSG00000231555; ENSG00000232804" "HSPA1B" "B4E3B6; hsa:3303; hsa:3304; P08107; P0DMV9; P19790; Q5JQI4; Q5SP17; Q9UQL9; Q9UQM0" "Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling; Measles virus infection" "PKR-mediated signaling; Neutrophil degranulation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Regulation of HSF1-mediated heat shock response; Attenuation phase" "12" "4" "1.040" "0.996" "1.025" "1.003" "0.996" "0.990" "1.013" "1.032" "1.013" "2726.0" "2835.0" "2714.3" "2795.3" "2733.7" "2715.7" "2699.9" "2760.4" "2813.1" "2762.5" "" "" "" "" "" "" "" "" "" "" "2554.3" "2346.0" "2519.9" "2160.9" "2330.1" "2594.6" "2466.9" "2451.0" "2813.1" "2659.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-109273256828227415" "False" "High" "IsMasterProtein" "Q07866" "Kinesin light chain 1 OS=Homo sapiens OX=9606 GN=KLC1 PE=1 SV=2" "0.000" "False" "74.746" "35" "21" "31" "18" "573" "65.3" "6.20" "100.23" "21" "cell adhesion;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00515, Pf13374, Pf13424" "3831" "ENSG00000126214" "KLC1" "A6NF62; F8VTM4; hsa:3831; Q07866; Q7RTM2; Q7RTM3; Q7RTM5; Q7RTP9; Q7RTQ3; Q7RTQ5; Q7RTQ6; Q86SF5; Q86TF5; Q86V74; Q86V75; Q86V76; Q86V77; Q86V78; Q86V79; Q96H62" "Alzheimer's disease and miRNA effects; IL-18 signaling pathway; Alzheimer's disease" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Signaling by ALK fusions and activated point mutants; RHO GTPases activate KTN1" "8" "2" "0.954" "0.996" "0.964" "1.007" "1.047" "0.980" "0.986" "0.993" "0.996" "3083.5" "2942.6" "3071.2" "2972.5" "3105.9" "3227.8" "3022.0" "3041.8" "3061.9" "3071.3" "" "" "" "" "" "" "" "" "" "" "2889.2" "2435.0" "2851.2" "2297.9" "2647.4" "3083.9" "2761.3" "2700.8" "3061.9" "2957.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7667668452715930583" "False" "High" "IsMasterProtein" "O60264" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 OS=Homo sapiens OX=9606 GN=SMARCA5 PE=1 SV=1" "0.000" "False" "74.647" "21" "24" "34" "24" "1052" "121.8" "8.09" "110.00" "24" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf09110, Pf09111" "8467" "ENSG00000153147" "SMARCA5" "hsa:8467; O60264" "10q11.21q11.23 copy number variation syndrome" "Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression" "5" "0" "0.994" "1.030" "1.012" "1.049" "1.033" "1.050" "1.035" "1.054" "1.042" "3794.3" "3770.1" "3909.9" "3841.6" "3979.0" "3920.2" "3982.2" "3927.9" "3997.3" "3954.6" "" "" "" "" "" "" "" "" "" "" "3555.2" "3119.7" "3629.9" "2969.7" "3391.6" "3745.3" "3638.7" "3487.6" "3997.3" "3807.7" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3936479494832144237" "False" "High" "IsMasterProtein" "Q8TCS8" "Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PNPT1 PE=1 SV=2" "0.000" "False" "74.491" "34" "27" "37" "27" "783" "85.9" "7.77" "115.73" "27" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00575, Pf01138, Pf03725, Pf03726" "87178" "ENSG00000138035" "PNPT1" "hsa:87178; Q53SU0; Q68CN1; Q7Z7D1; Q8IWX1; Q8TCS8; Q96T05; Q9BRU3; Q9BVX0" "Pyrimidine metabolism; miRNA degrading enzymes" "Mitochondrial RNA degradation" "3" "0" "0.983" "1.047" "0.978" "1.045" "1.066" "1.014" "1.014" "1.017" "1.026" "4939.0" "4856.9" "5170.4" "4829.4" "5159.6" "5266.4" "5007.9" "5009.0" "5023.7" "5067.9" "" "" "" "" "" "" "" "" "" "" "4627.8" "4019.0" "4800.1" "3733.4" "4397.9" "5031.5" "4575.9" "4447.5" "5023.7" "4879.7" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6546682892855641805" "False" "High" "IsMasterProtein" "P12268" "Inosine-5'-monophosphate dehydrogenase 2 OS=Homo sapiens OX=9606 GN=IMPDH2 PE=1 SV=2" "0.000" "False" "74.236" "41" "20" "42" "18" "514" "55.8" "6.90" "145.34" "20" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00478, Pf00571" "3615" "ENSG00000178035" "IMPDH2" "hsa:3615; P12268; Q6LEF3" "Rett syndrome" "Neutrophil degranulation; Potential therapeutics for SARS; Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "5" "2" "0.964" "1.014" "0.976" "0.964" "0.995" "0.901" "0.951" "1.000" "0.979" "4540.2" "4378.7" "4605.0" "4432.8" "4378.0" "4517.5" "4092.7" "4316.5" "4542.5" "4445.1" "" "" "" "" "" "" "" "" "" "" "4254.2" "3623.3" "4275.1" "3426.8" "3731.7" "4316.1" "3739.6" "3832.6" "4542.5" "4280.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7001879318500673012" "False" "High" "IsMasterProtein" "P11940" "Polyadenylate-binding protein 1 OS=Homo sapiens OX=9606 GN=PABPC1 PE=1 SV=2" "0.000" "False" "74.229" "30" "18" "53" "14" "636" "70.6" "9.50" "157.05" "18" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00658" "26986" "ENSG00000070756" "PABPC1" "hsa:26986; P11940; Q15097; Q93004" "Translation factors; Endoderm differentiation; VEGFA-VEGFR2 signaling; Acute viral myocarditis" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "13" "4" "1.004" "1.019" "1.049" "0.989" "0.984" "0.993" "0.978" "1.096" "0.985" "7601.5" "7634.8" "7748.0" "7971.8" "7515.1" "7477.4" "7544.6" "7432.9" "8328.2" "7487.6" "" "" "" "" "" "" "" "" "" "" "7122.6" "6317.7" "7193.1" "6162.6" "6405.7" "7143.9" "6893.8" "6599.7" "8328.2" "7209.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6441918618070782743" "False" "High" "IsMasterProtein" "P51610" "Host cell factor 1 OS=Homo sapiens OX=9606 GN=HCFC1 PE=1 SV=2" "0.000" "False" "74.084" "12" "23" "35" "23" "2035" "208.6" "7.46" "114.77" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01344, Pf13415, Pf13854" "3054" "ENSG00000172534" "HCFC1" "hsa:3054; P51610; Q6P4G5" "Mitochondrial gene expression; Pleural mesothelioma" "UCH proteinases; Formation of WDR5-containing histone-modifying complexes; Transcriptional activation of mitochondrial biogenesis; HATs acetylate histones" "6" "0" "0.987" "0.984" "0.989" "0.996" "0.984" "0.957" "1.016" "1.018" "0.989" "4588.7" "4528.3" "4517.4" "4538.7" "4571.9" "4515.0" "4392.5" "4663.9" "4670.3" "4537.0" "" "" "" "" "" "" "" "" "" "" "4299.6" "3747.1" "4193.8" "3508.6" "3897.0" "4313.7" "4013.5" "4141.1" "4670.3" "4368.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "565785606400917725" "False" "High" "IsMasterProtein" "P26639" "Threonine--tRNA ligase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TARS1 PE=1 SV=3" "0.000" "False" "74.066" "33" "23" "38" "22" "723" "83.4" "6.67" "118.10" "23" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf00587, Pf02824, Pf03129, Pf07973" "6897" "ENSG00000113407" "TARS1" "A8K8I1; B4DEG8; hsa:6897; P26639; Q96FP5; Q9BWA6" "" "Cytosolic tRNA aminoacylation" "1" "1" "0.939" "0.999" "0.924" "0.934" "0.955" "0.911" "0.939" "0.944" "0.941" "4521.9" "4247.1" "4517.9" "4177.0" "4223.5" "4318.9" "4119.3" "4244.6" "4270.6" "4253.6" "" "" "" "" "" "" "" "" "" "" "4237.0" "3514.4" "4194.3" "3229.0" "3600.0" "4126.3" "3764.0" "3768.8" "4270.6" "4095.6" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1511702505276588775" "False" "High" "IsMasterProtein" "Q12931" "Heat shock protein 75 kDa, mitochondrial OS=Homo sapiens OX=9606 GN=TRAP1 PE=1 SV=3" "0.000" "False" "73.984" "32" "20" "52" "19" "704" "80.1" "8.21" "175.57" "20" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00183" "10131" "ENSG00000126602" "TRAP1" "B4DR68; D3DUC8; F5H897; hsa:10131; O43642; O75235; Q12931; Q9UHL5" "TNF-alpha signaling pathway; TGF-beta signaling pathway; Clock-controlled autophagy in bone metabolism" "Respiratory electron transport" "4" "0" "0.987" "0.993" "0.958" "0.979" "1.004" "0.954" "1.004" "0.982" "0.950" "4371.6" "4316.3" "4343.0" "4190.0" "4280.2" "4390.2" "4168.8" "4390.8" "4294.4" "4151.0" "" "" "" "" "" "" "" "" "" "" "4096.2" "3571.7" "4032.0" "3239.1" "3648.4" "4194.4" "3809.1" "3898.6" "4294.4" "3996.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4471349255838518587" "False" "High" "IsMasterProtein" "P23526" "Adenosylhomocysteinase OS=Homo sapiens OX=9606 GN=AHCY PE=1 SV=4" "0.000" "False" "73.430" "44" "20" "54" "18" "432" "47.7" "6.34" "151.71" "20" "other metabolic processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00670, Pf05221" "191" "ENSG00000101444" "AHCY" "A8K307; B3KUN3; E1P5P2; F5H737; hsa:191; P23526; Q96A36" "Folate metabolism; Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; Ethanol effects on histone modifications; Spina bifida" "Methylation; Sulfur amino acid metabolism; Metabolism of ingested SeMet, Sec, MeSec into H2Se; Defective AHCY causes HMAHCHD" "11" "1" "1.013" "1.018" "0.980" "0.987" "0.986" "0.959" "0.979" "0.983" "0.975" "5855.0" "5931.6" "5958.4" "5738.9" "5776.5" "5775.8" "5612.1" "5731.2" "5755.8" "5706.5" "" "" "" "" "" "" "" "" "" "" "5486.1" "4908.3" "5531.6" "4436.4" "4923.7" "5518.3" "5128.0" "5088.7" "5755.8" "5494.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8574312361860662093" "False" "High" "IsMasterProtein" "Q92620" "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 OS=Homo sapiens OX=9606 GN=DHX38 PE=1 SV=2" "0.000" "False" "73.413" "21" "23" "35" "23" "1227" "140.4" "6.54" "105.47" "23" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "9785" "ENSG00000140829" "DHX38" "B4DVG8; D3DWS7; hsa:9785; O75212; Q92620; Q96HN7" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "5" "0" "0.996" "0.933" "0.990" "0.962" "0.975" "1.113" "0.926" "0.914" "0.985" "4029.9" "4013.5" "3760.5" "3990.2" "3878.0" "3928.3" "4484.2" "3731.0" "3683.1" "3970.1" "" "" "" "" "" "" "" "" "" "" "3776.0" "3321.2" "3491.2" "3084.6" "3305.5" "3753.1" "4097.3" "3312.7" "3683.1" "3822.7" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7740854368523393254" "False" "High" "IsMasterProtein" "Q9NR30" "Nucleolar RNA helicase 2 OS=Homo sapiens OX=9606 GN=DDX21 PE=1 SV=5" "0.000" "False" "73.384" "29" "22" "28" "20" "783" "87.3" "9.28" "92.40" "22" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08152" "9188" "ENSG00000165732" "DDX21" "B2RDL0; hsa:9188; Q13436; Q5VX41; Q68D35; Q9NR30" "10q11.21q11.23 copy number variation syndrome; Rubinstein-Taybi syndrome 1" "B-WICH complex positively regulates rRNA expression; Major pathway of rRNA processing in the nucleolus and cytosol" "4" "2" "1.017" "1.112" "1.014" "1.144" "1.123" "1.207" "1.340" "1.224" "1.192" "2071.3" "2106.8" "2304.2" "2100.5" "2368.8" "2327.0" "2500.0" "2774.6" "2536.1" "2468.8" "" "" "" "" "" "" "" "" "" "" "1940.8" "1743.4" "2139.2" "1623.8" "2019.1" "2223.3" "2284.3" "2463.6" "2536.1" "2377.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1799847195195984928" "False" "High" "IsMasterProtein" "Q5VYK3" "Proteasome adapter and scaffold protein ECM29 OS=Homo sapiens OX=9606 GN=ECPAS PE=1 SV=2" "0.000" "False" "73.140" "15" "24" "34" "24" "1845" "204.2" "7.12" "99.62" "24" "cell organization and biogenesis" "cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf12755, Pf13001" "23392" "ENSG00000136813" "ECPAS" "A0A804HJA4; B3KXF2; O15074; Q5VYK3; Q8WU82" "" "" "0" "0" "0.974" "0.997" "0.996" "0.968" "0.962" "0.953" "0.973" "1.013" "0.985" "3016.8" "2937.9" "3007.2" "3005.7" "2920.4" "2902.9" "2874.3" "2934.6" "3057.5" "2972.0" "" "" "" "" "" "" "" "" "" "" "2826.7" "2431.0" "2791.8" "2323.6" "2489.2" "2773.5" "2626.4" "2605.6" "3057.5" "2861.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4081821255654730279" "False" "High" "IsMasterProtein" "Q13618" "Cullin-3 OS=Homo sapiens OX=9606 GN=CUL3 PE=1 SV=2" "0.000" "False" "73.036" "30" "24" "28" "24" "768" "88.9" "8.48" "89.43" "24" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00888, Pf10557" "8452" "ENSG00000036257" "CUL3" "A8K536; B8ZZC3; hsa:8452; O75415; Q13618; Q569L3; Q9UBI8; Q9UET7" "Hereditary leiomyomatosis and renal cell carcinoma pathway; Hedgehog signaling pathway; NRF2-ARE regulation; 22q11.2 copy number variation syndrome; Head and neck squamous cell carcinoma; 1p36 copy number variation syndrome" "Potential therapeutics for SARS; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Degradation of DVL; Hedgehog 'on' state; Regulation of RAS by GAPs; KEAP1-NFE2L2 pathway; RHOBTB3 ATPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "16" "0" "0.951" "0.994" "0.997" "0.984" "0.981" "0.975" "0.961" "0.973" "0.977" "2882.2" "2741.5" "2864.9" "2873.1" "2836.4" "2828.9" "2810.7" "2769.8" "2803.6" "2816.5" "" "" "" "" "" "" "" "" "" "" "2700.6" "2268.6" "2659.7" "2221.0" "2417.6" "2702.7" "2568.3" "2459.3" "2803.6" "2711.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1612190288293860915" "False" "High" "IsMasterProtein" "P60842" "Eukaryotic initiation factor 4A-I OS=Homo sapiens OX=9606 GN=EIF4A1 PE=1 SV=1" "0.000" "False" "72.961" "36" "17" "57" "9" "406" "46.1" "5.48" "163.56" "17" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1973" "ENSG00000161960" "EIF4A1" "B2R6L8; D3DTP9; hsa:1973; J3QLC4; P04765; P60842; Q5U018; Q61516" "Translation factors; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Interferon type I signaling pathways" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "13" "6" "1.006" "1.039" "1.036" "1.010" "1.007" "0.959" "0.988" "1.053" "1.019" "4797.2" "4825.2" "4983.0" "4971.3" "4844.8" "4830.4" "4601.1" "4737.5" "5049.3" "4889.1" "" "" "" "" "" "" "" "" "" "" "4495.0" "3992.8" "4626.1" "3843.0" "4129.6" "4615.0" "4204.1" "4206.4" "5049.3" "4707.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-253239951813173210" "False" "High" "IsMasterProtein" "Q9H2M9" "Rab3 GTPase-activating protein non-catalytic subunit OS=Homo sapiens OX=9606 GN=RAB3GAP2 PE=1 SV=1" "0.000" "False" "72.886" "17" "22" "31" "21" "1393" "155.9" "5.62" "86.73" "22" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf14655, Pf14656" "25782" "ENSG00000118873" "RAB3GAP2" "A6H8V0; hsa:25782; O75872; Q9H2M9; Q9HAB0; Q9UFJ7; Q9UQ15" "" "RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic" "2" "1" "1.034" "1.002" "1.052" "1.038" "1.040" "1.006" "0.993" "0.971" "1.013" "2455.1" "2538.1" "2461.0" "2582.8" "2547.7" "2552.2" "2470.0" "2437.0" "2384.2" "2486.1" "" "" "" "" "" "" "" "" "" "" "2300.4" "2100.3" "2284.7" "1996.6" "2171.6" "2438.4" "2256.9" "2163.8" "2384.2" "2393.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3405603430523799899" "False" "High" "IsMasterProtein" "P52888" "Thimet oligopeptidase OS=Homo sapiens OX=9606 GN=THOP1 PE=1 SV=2" "0.000" "False" "72.845" "36" "24" "35" "24" "689" "78.8" "6.05" "113.69" "24" "protein metabolism;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01432" "7064" "ENSG00000172009" "THOP1" "B3KSE2; hsa:7064; P52888; Q9UCB3" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.026" "0.986" "0.991" "0.968" "0.979" "0.938" "0.991" "1.035" "0.975" "3461.7" "3550.1" "3412.2" "3431.3" "3352.4" "3390.7" "3245.7" "3430.9" "3581.7" "3375.5" "" "" "" "" "" "" "" "" "" "" "3243.6" "2937.7" "3167.8" "2652.5" "2857.5" "3239.5" "2965.7" "3046.3" "3581.7" "3250.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5903683586191117105" "False" "High" "IsMasterProtein" "Q13200" "26S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PSMD2 PE=1 SV=3" "0.000" "False" "72.712" "22" "20" "45" "20" "908" "100.1" "5.20" "130.75" "20" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01851, Pf17781, Pf18051" "5708" "ENSG00000175166" "PSMD2" "B4DX07; B4DXY1; E7EW34; E9PCS3; hsa:5708; Q12932; Q13200; Q15321; Q53XQ4; Q96I12" "Proteasome degradation; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "0.973" "1.012" "0.938" "0.984" "0.985" "0.909" "0.974" "1.033" "0.978" "4418.8" "4297.9" "4471.9" "4146.1" "4349.1" "4353.8" "4015.0" "4303.5" "4563.5" "4319.7" "" "" "" "" "" "" "" "" "" "" "4140.4" "3556.5" "4151.6" "3205.1" "3707.0" "4159.7" "3668.6" "3821.1" "4563.5" "4159.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7405227159340641842" "False" "High" "IsMasterProtein" "P62195" "26S proteasome regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMC5 PE=1 SV=1" "0.000" "False" "72.226" "48" "17" "32" "16" "406" "45.6" "7.55" "116.64" "17" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00004, Pf16450, Pf17862" "5705" "ENSG00000087191" "PSMC5" "A8K3Z3; A8K763; hsa:5705; O35051; O43208; P47210; P52915; P52916; P62195" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Alzheimer's disease" "Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "0.957" "0.974" "1.003" "0.998" "0.967" "0.966" "0.992" "0.945" "0.971" "2427.0" "2322.6" "2363.9" "2434.9" "2423.0" "2346.5" "2344.3" "2406.9" "2294.4" "2356.5" "" "" "" "" "" "" "" "" "" "" "2274.1" "1921.9" "2194.6" "1882.3" "2065.3" "2241.9" "2142.1" "2137.1" "2294.4" "2269.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4113768837461094803" "False" "High" "IsMasterProtein" "A0AVT1" "Ubiquitin-like modifier-activating enzyme 6 OS=Homo sapiens OX=9606 GN=UBA6 PE=1 SV=1" "0.000" "False" "71.952" "21" "22" "34" "22" "1052" "117.9" "6.14" "101.77" "22" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00899, Pf09358, Pf10585, Pf16190, Pf16191" "55236" "ENSG00000033178" "UBA6" "A0AVT1; A6N8M7; B2RAV3; hsa:55236; Q4W5K0; Q6UV21; Q86T78; Q86TC7; Q8N5T3; Q8N9E4; Q9H3T7; Q9NVC9" "" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "0.941" "0.986" "0.979" "0.972" "0.945" "0.937" "0.953" "0.972" "0.981" "4244.8" "3993.3" "4183.6" "4157.7" "4124.1" "4013.2" "3978.4" "4046.0" "4123.9" "4165.3" "" "" "" "" "" "" "" "" "" "" "3977.4" "3304.4" "3883.9" "3214.1" "3515.2" "3834.3" "3635.2" "3592.4" "4123.9" "4010.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1764632123327779223" "False" "High" "IsMasterProtein" "P46060" "Ran GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RANGAP1 PE=1 SV=1" "0.000" "False" "71.411" "30" "16" "30" "16" "587" "63.5" "4.68" "102.29" "16" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf07834, Pf13516" "5905" "ENSG00000100401" "RANGAP1" "hsa:5905; P46060; Q96JJ2" "22q11.2 copy number variation syndrome; IL-18 signaling pathway" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Rev-mediated nuclear export of HIV RNA; SUMOylation of DNA replication proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of nuclear envelope proteins" "12" "0" "0.997" "1.022" "1.025" "1.021" "1.004" "1.015" "1.006" "0.989" "1.020" "2894.2" "2884.8" "2957.1" "2966.4" "2955.4" "2905.2" "2937.7" "2910.7" "2863.7" "2951.2" "" "" "" "" "" "" "" "" "" "" "2711.9" "2387.1" "2745.3" "2293.2" "2519.1" "2775.6" "2684.3" "2584.4" "2863.7" "2841.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3394918450034897638" "False" "High" "IsMasterProtein" "P55884" "Eukaryotic translation initiation factor 3 subunit B OS=Homo sapiens OX=9606 GN=EIF3B PE=1 SV=3" "0.000" "False" "71.312" "27" "19" "30" "19" "814" "92.4" "5.00" "98.30" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08662" "8662" "ENSG00000106263" "EIF3B" "A4D208; hsa:8662; P55884; Q2NL77; Q9UMF9" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "0.981" "1.014" "0.968" "0.965" "0.938" "1.062" "1.043" "1.048" "1.012" "2397.3" "2352.2" "2430.3" "2319.4" "2313.1" "2247.7" "2545.4" "2499.5" "2511.2" "2426.6" "" "" "" "" "" "" "" "" "" "" "2246.2" "1946.4" "2256.2" "1793.0" "1971.6" "2147.4" "2325.8" "2219.3" "2511.2" "2336.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9124965961007810906" "False" "High" "IsMasterProtein" "P11387" "DNA topoisomerase 1 OS=Homo sapiens OX=9606 GN=TOP1 PE=1 SV=2" "0.000" "False" "71.197" "29" "24" "39" "24" "765" "90.7" "9.31" "108.60" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf01028, Pf02919, Pf14370" "7150" "ENSG00000198900" "TOP1" "A8KA78; E1P5W3; hsa:7150; O43256; P11387; Q12855; Q12856; Q15610; Q5TFY3; Q9UJN0" "Ebola virus infection in host; 15q25 copy number variation" "SUMOylation of DNA replication proteins" "3" "0" "0.965" "1.038" "1.073" "1.090" "1.055" "1.160" "1.230" "1.113" "1.081" "4119.5" "3975.5" "4275.3" "4419.8" "4489.3" "4344.4" "4780.4" "5067.7" "4586.5" "4454.8" "" "" "" "" "" "" "" "" "" "" "3859.9" "3289.6" "3969.1" "3416.7" "3826.6" "4150.7" "4368.0" "4499.6" "4586.5" "4289.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3527140061799616806" "False" "High" "IsMasterProtein" "Q9BW19" "Kinesin-like protein KIFC1 OS=Homo sapiens OX=9606 GN=KIFC1 PE=1 SV=2" "0.000" "False" "71.057" "34" "19" "27" "19" "673" "73.7" "8.98" "97.01" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cytoplasmic organelle" "cytoskeletal activity;other molecular function" "Pf00225" "3833" "ENSG00000204197; ENSG00000233450; ENSG00000237649" "KIFC1" "hsa:3833; O60887; Q14834; Q4KMP0; Q5SU09; Q6GMS7; Q6P4A5; Q9BW19; Q9UQP7" "" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "2" "0" "1.032" "1.009" "1.116" "1.027" "1.048" "1.028" "0.991" "0.982" "1.052" "2630.5" "2713.6" "2654.3" "2935.3" "2702.9" "2757.1" "2704.4" "2607.2" "2583.1" "2768.4" "" "" "" "" "" "" "" "" "" "" "2464.8" "2245.5" "2464.2" "2269.1" "2303.8" "2634.2" "2471.1" "2314.9" "2583.1" "2665.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5335677543697524354" "False" "High" "IsMasterProtein" "P17844" "Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens OX=9606 GN=DDX5 PE=1 SV=1" "0.000" "False" "70.953" "33" "21" "38" "14" "614" "69.1" "8.92" "119.64" "21" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08061" "1655" "ENSG00000108654" "DDX5" "B4DLW8; B5BU21; D3DU32; E7ETL9; hsa:1655; O75681; P17844; Q53Y61" "Ciliary landscape" "Estrogen-dependent gene expression; SUMOylation of transcription cofactors; mRNA Splicing - Major Pathway; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome" "6" "0" "0.987" "1.058" "0.973" "1.034" "1.074" "1.057" "1.125" "1.048" "1.029" "4049.2" "3995.3" "4285.3" "3939.5" "4186.2" "4346.8" "4280.8" "4556.1" "4244.9" "4166.8" "" "" "" "" "" "" "" "" "" "" "3794.1" "3306.1" "3978.4" "3045.4" "3568.2" "4153.0" "3911.5" "4045.4" "4244.9" "4012.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4377208032786879179" "False" "High" "IsMasterProtein" "P51858" "Hepatoma-derived growth factor OS=Homo sapiens OX=9606 GN=HDGF PE=1 SV=1" "0.000" "False" "70.747" "67" "17" "40" "16" "240" "26.8" "4.73" "137.77" "17" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00855" "3068" "ENSG00000143321" "HDGF" "B3KU21; D3DVC9; P51858; Q5SZ07; Q5SZ08; Q5SZ09" "IL-18 signaling pathway" "XBP1(S) activates chaperone genes" "2" "0" "0.995" "0.946" "0.897" "0.903" "0.902" "0.907" "0.903" "0.947" "0.925" "7554.3" "7515.9" "7142.8" "6779.2" "6821.1" "6814.9" "6852.2" "6823.3" "7156.0" "6991.2" "" "" "" "" "" "" "" "" "" "" "7078.3" "6219.4" "6631.2" "5240.6" "5814.2" "6511.0" "6261.1" "6058.4" "7156.0" "6731.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4054510205684443302" "False" "High" "IsMasterProtein" "Q9Y6X8" "Zinc fingers and homeoboxes protein 2 OS=Homo sapiens OX=9606 GN=ZHX2 PE=1 SV=1" "0.000" "False" "70.627" "31" "22" "27" "22" "837" "92.3" "6.86" "92.08" "22" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf18387" "22882" "ENSG00000178764" "ZHX2" "hsa:22882; Q9Y6X8" "" "" "0" "0" "0.944" "0.988" "0.961" "0.996" "0.980" "0.942" "0.950" "0.946" "0.990" "3287.1" "3101.6" "3247.6" "3159.9" "3275.3" "3221.5" "3097.6" "3122.1" "3111.2" "3252.7" "" "" "" "" "" "" "" "" "" "" "3080.0" "2566.5" "3015.0" "2442.7" "2791.8" "3077.8" "2830.4" "2772.1" "3111.2" "3131.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6973365880698085835" "False" "High" "IsMasterProtein" "Q9UHD8" "Septin-9 OS=Homo sapiens OX=9606 GN=SEPTIN9 PE=1 SV=2" "0.000" "False" "70.543" "35" "21" "45" "21" "586" "65.4" "8.97" "134.55" "21" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00735" "10801" "ENSG00000184640" "SEPTIN9" "A8K2V3; B3KPM0; B4DTL9; B4E0N2; B4E274; B7Z654; hsa:10801; Q96QF3; Q96QF4; Q96QF5; Q9HA04; Q9UG40; Q9UHD8; Q9Y5W4" "" "" "0" "0" "0.986" "0.983" "0.964" "0.930" "0.926" "0.918" "0.928" "0.949" "0.933" "4856.9" "4787.6" "4776.5" "4684.0" "4516.3" "4498.7" "4456.9" "4505.9" "4608.8" "4532.3" "" "" "" "" "" "" "" "" "" "" "4550.9" "3961.6" "4434.3" "3621.0" "3849.6" "4298.1" "4072.4" "4000.8" "4608.8" "4364.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5372925708799750934" "False" "High" "IsMasterProtein" "Q15046" "Lysine--tRNA ligase OS=Homo sapiens OX=9606 GN=KARS1 PE=1 SV=3" "0.000" "False" "70.443" "33" "21" "36" "21" "597" "68.0" "6.35" "123.04" "21" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336" "3735" "ENSG00000065427" "KARS1" "A8MSK1; D3DUK4; hsa:3735; O14946; Q15046; Q96J25; Q9HB23" "" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "3" "0" "1.009" "1.014" "0.972" "0.977" "0.973" "0.958" "0.971" "1.039" "0.983" "4313.6" "4350.5" "4374.5" "4191.7" "4215.3" "4195.4" "4132.8" "4190.6" "4480.3" "4242.0" "" "" "" "" "" "" "" "" "" "" "4041.8" "3600.0" "4061.1" "3240.4" "3593.0" "4008.3" "3776.3" "3720.8" "4480.3" "4084.5" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5486623488286150829" "False" "High" "IsMasterProtein" "Q9UBT2" "SUMO-activating enzyme subunit 2 OS=Homo sapiens OX=9606 GN=UBA2 PE=1 SV=2" "0.000" "False" "69.889" "32" "18" "39" "18" "640" "71.2" "5.29" "123.07" "18" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00899, Pf14732, Pf16195" "10054" "ENSG00000126261" "UBA2" "B3KWB9; hsa:10054; O95605; Q59H87; Q6IBP6; Q9NTJ1; Q9UBT2; Q9UED2" "" "SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "2" "0" "0.975" "0.981" "0.966" "0.956" "0.941" "0.968" "0.983" "0.967" "0.946" "4433.2" "4323.2" "4347.6" "4284.3" "4236.6" "4173.4" "4293.4" "4355.6" "4285.9" "4192.3" "" "" "" "" "" "" "" "" "" "" "4153.9" "3577.4" "4036.2" "3312.0" "3611.2" "3987.3" "3923.1" "3867.3" "4285.9" "4036.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8291794919948140528" "False" "High" "IsMasterProtein" "Q14203" "Dynactin subunit 1 OS=Homo sapiens OX=9606 GN=DCTN1 PE=1 SV=3" "0.000" "False" "69.875" "19" "22" "25" "22" "1278" "141.6" "5.81" "83.29" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf12455" "1639" "ENSG00000204843" "DCTN1" "A8MY36; B4DM45; E9PFS5; E9PGE1; G5E9H4; hsa:1639; O95296; Q14203; Q6IQ37; Q9BRM9; Q9UIU1; Q9UIU2" "Vasopressin-regulated water reabsorption; HDAC6 interactions in the central nervous system" "Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; XBP1(S) activates chaperone genes" "8" "0" "0.995" "0.998" "1.030" "1.037" "0.994" "0.993" "0.979" "0.979" "1.022" "3180.8" "3163.7" "3175.8" "3277.5" "3297.5" "3161.3" "3158.2" "3115.0" "3112.9" "3251.2" "" "" "" "" "" "" "" "" "" "" "2980.4" "2617.9" "2948.3" "2533.7" "2810.7" "3020.4" "2885.7" "2765.8" "3112.9" "3130.4" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8957423501143175457" "False" "High" "IsMasterProtein" "Cont_P81948" "Tubulin alpha-4A chain OS=Bos taurus OX=9913 GN=TUBA4A PE=1 SV=2" "0.000" "True" "69.664" "49" "18" "49" "4" "448" "49.9" "5.06" "154.29" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "100151951; 100302357; 100354352; 100400294; 100449357; 100734500; 100767686; 100995882; 101006121; 101095277; 101148853; 101379814; 101569770; 101606396; 101677236; 101838478; 101926805; 101969889; 102012828; 102177846; 102532857; 102746509; 102841369; 102928867; 102962068; 103007004; 103072784; 103110543; 103217904; 103261248; 103662744; 103727749; 104660054; 105064041; 105481257; 105504700; 105528059; 105587029; 105808789; 105857673; 105996598; 107138719; 107516732; 109265033; 109571050; 22145; 316531; 470654; 478918; 702583; 7277; 777775" "ENSANAG00000028048; ENSBIXG00005021445; ENSBMSG00010001061; ENSBTAG00000030974; ENSCAFG00000015209; ENSCAFG00020027000; ENSCAFG00030011006; ENSCAFG00845029842; ENSCANG00000024607; ENSCATG00000033332; ENSCGRG00001024425; ENSCHIG00000002435; ENSCJAG00000070762; ENSCLAG00000011603; ENSCPOG00000037151; ENSCSAG00000008100; ENSFCAG00000038881; ENSG00000127824; ENSGGOG00000023578; ENSJJAG00000011005; ENSLCNG00005009789; ENSMFAG00000007541; ENSMICG00000035827; ENSMLEG00000029671; ENSMMMG00000020450; ENSMMSG00000019327; ENSMMUG00000019628; ENSMNEG00000039170; ENSMSIG00000018170; ENSMUSG00000026202; ENSNGAG00000020443; ENSNLEG00000027445; ENSOARG00000020020; ENSOCUG00000026994; ENSPANG00000041659; ENSPCOG00000023925; ENSPEMG00000029240; ENSPLOG00000016209; ENSPPAG00000011142; ENSPPYG00000013203; ENSPSMG00000025346; ENSPSNG00000018656; ENSPTEG00000039375; ENSPTIG00000021758; ENSPTRG00000012949; ENSRNOG00000003597; ENSRNOG00055010434; ENSRNOG00060007884; ENSRNOG00065008885; ENSRROG00000044949; ENSSSCG00000016216; ENSSSCG00025016272; ENSSSCG00035020742; ENSSSCG00040017674; ENSSSCG00050039745; ENSSSCG00070016481; ENSSTOG00000019497; ENSSVLG00005016017; ENSTGEG00000012532; ENSTSYG00000011750; ENSUMAG00000018763; ENSUPAG00010012836; ENSVVUG00000025771" "LOC101334183; LOC102532857; LOC102746509; LOC103662744; LOC106970047; LOC109265033; LOC111143142; LOC111171848; LOC112411846; LOC112838391; LOC112872268; LOC112922524; LOC113920876; LOC114495658; LOC118898366; Tuba4a; TUBA4A" "A0A0D9R6X5; A0A1S2ZI83; A0A1S3GBQ2; A0A1U7Q653; A0A1U7TVH0; A0A286ZNY1; A0A2I2UZ20; A0A2I2YM80; A0A2J8NG28; A0A2J8TUH3; A0A2K5DHU1; A0A2K5HTH7; A0A2K5M1H8; A0A2K5Y6I3; A0A2K6D749; A0A2K6GBF8; A0A2K6RS93; A0A2R8ZC21; A0A2U3W3Z0; A0A2U3YH71; A0A2Y9IV09; A0A2Y9N2F1; A0A340WE79; A0A341CW34; A0A384AKZ1; A0A384C1E6; A0A3Q7QMN7; A0A3Q7SCG6; A0A452DNE3; A0A484GTP9; A0A485MVS4; A0A4W2GGR2; A0A4X1UG19; A0A5N3WUA1; A0A663D8Z2; A0A667GI79; A0A6D2XJT6; A0A6I9I9T5; A0A6I9L693; A0A6J1YN80; A0A6J2LL95; A0A6J3RLQ7; A0A6P3CX09; A0A6P3FIC2; A0A6P5D399; A0A6P6ISG9; A0A6P9F8Q5; A0A7J8JNJ1; A0A811ZBS6; A0A8B7EMV4; A0A8B7KBC2; A0A8B8XXA4; A0A8C0LT90; A0A8C0MZ87; A0A8C2N284; A0A8C2VS48; A0A8C5KB95; A0A8C6E681; A0A8C6EXI3; A0A8C6HJF8; A0A8C6RPC4; A0A8C8XN00; A0A8C9ASB4; A0A8C9CIF4; A0A8C9IX37; A0A8C9KT44; A0A8D2D621; A0A8D2K0Z6; A0A8D2KIE8; A0A8I3Q1H9; A0A8I5NZD6; A0A8U0N0J8; A0A9B0TPY2; A0A9V1FEX0; A0A9W3GNM5; A6JVZ9; A8MUB1; aju:106970047; B3KNQ6; biu:109571050; bta:777775; C5ISA2; caty:105587029; cfr:102522237; chx:102177846; cjc:100400294; cpoc:100734500; csyr:103261248; dle:111171848; dord:105996598; elk:111143142; F6QRE8; F7HZP3; fca:101095277; G1RDQ0; G1TR82; H0V3I8; H2P8P0; H2QJG6; hsa:7277; I3NHW3; K9IKB3; lww:102746509; maua:101838478; mcf:101926805; mmu:22145; mmur:105857673; mpuf:101677236; nasi:112411846; ngi:103727749; oas:100302357; ocu:100354352; oro:101379814; P05215; P68366; P68367; P68368; P81948; panu:101006121; pcoo:112872268; pdic:114495658; pon:100449357; pps:100995882; ptg:102962068; Q17QT1; Q3TY31; Q5E986; Q5XIF6; ray:107516732; rno:316531; rro:104660054; ssc:100151951; umr:103662744; vpc:102532857; vvp:112922524" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease; HDAC6 interactions in the central nervous system" "Platelet degranulation ; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Intraflagellar transport; COPI-mediated anterograde transport; The role of GTSE1 in G2/M progression after G2 checkpoint; Carboxyterminal post-translational modifications of tubulin; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; PKR-mediated signaling; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Intraflagellar transport; PKR-mediated signaling; Recycling pathway of L1; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Platelet degranulation ; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state; Platelet degranulation ; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation; COPI-mediated anterograde transport; Separation of Sister Chromatids; Anchoring of the basal body to the plasma membrane; PKR-mediated signaling; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; AURKA Activation by TPX2; EML4 and NUDC in mitotic spindle formation; Intraflagellar transport; Carboxyterminal post-translational modifications of tubulin; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recycling pathway of L1; Hedgehog 'off' state; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; The role of GTSE1 in G2/M progression after G2 checkpoint; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Platelet degranulation ; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; The role of GTSE1 in G2/M progression after G2 checkpoint; MHC class II antigen presentation; RHO GTPases Activate Formins; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Intraflagellar transport; Separation of Sister Chromatids; EML4 and NUDC in mitotic spindle formation; Hedgehog 'off' state; Loss of Nlp from mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Kinesins; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; RHO GTPases activate IQGAPs; Carboxyterminal post-translational modifications of tubulin; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; MHC class II antigen presentation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; COPI-independent Golgi-to-ER retrograde traffic; Anchoring of the basal body to the plasma membrane; Platelet degranulation ; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-dependent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Kinesins; PKR-mediated signaling; COPI-mediated anterograde transport; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Hedgehog 'off' state; Intraflagellar transport; Carboxyterminal post-translational modifications of tubulin; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Sealing of the nuclear envelope (NE) by ESCRT-III; Aggrephagy; Recycling pathway of L1; RHO GTPases activate IQGAPs; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane" "160" "0" "0.994" "1.060" "1.009" "1.013" "1.010" "0.892" "0.893" "0.868" "0.947" "421.1" "418.5" "446.4" "424.8" "426.4" "425.2" "375.7" "376.1" "365.5" "398.9" "" "" "" "" "" "" "" "" "" "" "394.6" "346.3" "414.4" "328.4" "363.5" "406.2" "343.3" "333.9" "365.5" "384.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7479442399663165637" "False" "High" "IsMasterProtein" "Cont_P02769" "Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4" "0.000" "True" "69.623" "36" "22" "34" "21" "607" "69.2" "6.18" "108.54" "22" "stress response;other biological processes" "non-structural extracellular;other cell component" "nucleic acid binding activity;other molecular function" "Pf00273" "280717" "" "ALB" "A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2" "" "" "0" "1" "1.000" "0.939" "1.098" "1.372" "1.460" "1.318" "1.310" "1.427" "1.176" "2448.8" "2448.6" "2299.5" "2689.6" "3360.6" "3574.5" "3227.6" "3208.7" "3495.2" "2880.4" "" "" "" "" "" "" "" "" "" "" "2294.6" "2026.2" "2134.8" "2079.2" "2864.5" "3415.1" "2949.2" "2849.0" "3495.2" "2773.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5568233219206595783" "False" "High" "IsMasterProtein" "Q9ULT8" "E3 ubiquitin-protein ligase HECTD1 OS=Homo sapiens OX=9606 GN=HECTD1 PE=1 SV=4" "0.000" "False" "69.477" "10" "24" "27" "24" "2610" "289.2" "5.35" "81.19" "24" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf00632, Pf06701, Pf07738, Pf12796, Pf18410" "25831" "ENSG00000092148" "HECTD1" "D3DS86; hsa:25831; Q6P445; Q86VJ1; Q96F34; Q9UFZ7; Q9ULT8" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.033" "0.993" "1.040" "1.010" "1.013" "1.000" "0.964" "0.972" "1.035" "1529.8" "1579.7" "1518.8" "1591.6" "1545.7" "1550.0" "1529.4" "1474.7" "1486.3" "1583.0" "" "" "" "" "" "" "" "" "" "" "1433.4" "1307.2" "1410.0" "1230.4" "1317.5" "1480.9" "1397.5" "1309.4" "1486.3" "1524.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4900440247780228765" "False" "High" "IsMasterProtein" "Q13616" "Cullin-1 OS=Homo sapiens OX=9606 GN=CUL1 PE=1 SV=2" "0.000" "False" "69.005" "25" "20" "33" "20" "776" "89.6" "8.00" "102.65" "20" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8454" "ENSG00000055130" "CUL1" "D3DWG3; hsa:8454; O60719; Q08AL6; Q13616; Q8IYW1" "Cell cycle; TNF-alpha signaling pathway; Parkin-ubiquitin proteasomal system pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; Pleural mesothelioma; Notch signaling pathway" "Iron uptake and transport; Circadian Clock; Antigen processing: Ubiquitination & Proteasome degradation; Orc1 removal from chromatin; Regulation of RUNX2 expression and activity; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; Cyclin D associated events in G1; Regulation of BACH1 activity; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Nuclear events stimulated by ALK signaling in cancer; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "41" "0" "0.954" "1.014" "0.956" "0.995" "1.011" "0.949" "1.002" "1.007" "0.992" "4274.0" "4078.7" "4335.1" "4084.9" "4253.0" "4319.5" "4055.4" "4281.7" "4302.1" "4239.5" "" "" "" "" "" "" "" "" "" "" "4004.7" "3375.1" "4024.6" "3157.8" "3625.2" "4126.9" "3705.6" "3801.7" "4302.1" "4082.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7048585715635486560" "False" "High" "IsMasterProtein" "Q13885" "Tubulin beta-2A chain OS=Homo sapiens OX=9606 GN=TUBB2A PE=1 SV=1" "0.000" "False" "68.889" "41" "15" "82" "1" "445" "49.9" "4.89" "222.96" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7280" "ENSG00000137267" "TUBB2A" "hsa:7280; Q13885; Q6FGZ8; Q8IWR2" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; MHC class II antigen presentation; HCMV Early Events; Formation of tubulin folding intermediates by CCT/TriC; Prefoldin mediated transfer of substrate to CCT/TriC; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Hedgehog 'off' state" "35" "0" "0.997" "1.026" "0.969" "0.972" "0.954" "0.950" "0.945" "0.874" "0.982" "137.3" "136.9" "140.8" "133.1" "133.4" "130.9" "130.4" "129.8" "119.9" "134.7" "" "" "" "" "" "" "" "" "" "" "128.6" "113.3" "130.7" "102.9" "113.7" "125.1" "119.1" "115.2" "119.9" "129.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6707926075363841764" "False" "High" "IsMasterProtein" "Q99798" "Aconitate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ACO2 PE=1 SV=2" "0.000" "False" "68.840" "32" "21" "28" "21" "780" "85.4" "7.61" "89.65" "21" "other metabolic processes;stress response;developmental processes" "cytosol;mitochondrion" "other molecular function" "Pf00330, Pf00694" "50" "ENSG00000100412" "ACO2" "hsa:50; O75809; Q5JZ41; Q6FHX0; Q8TAQ6; Q99798" "Amino acid metabolism; Metabolic reprogramming in colon cancer; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein import; Mitochondrial protein degradation" "7" "0" "0.984" "1.012" "0.974" "0.964" "0.968" "0.962" "0.958" "0.955" "0.964" "2842.2" "2795.9" "2875.6" "2767.6" "2740.7" "2751.7" "2734.1" "2723.2" "2713.0" "2740.0" "" "" "" "" "" "" "" "" "" "" "2663.2" "2313.6" "2669.7" "2139.5" "2336.1" "2629.0" "2498.2" "2417.9" "2713.0" "2638.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4943408873611006946" "False" "High" "IsMasterProtein" "Q02790" "Peptidyl-prolyl cis-trans isomerase FKBP4 OS=Homo sapiens OX=9606 GN=FKBP4 PE=1 SV=3" "0.000" "False" "68.582" "46" "22" "51" "22" "459" "51.8" "5.43" "154.22" "22" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00254, Pf00515" "2288" "ENSG00000004478" "FKBP4" "D3DUQ1; hsa:2288; Q02790; Q9UCP1; Q9UCV7" "Androgen receptor signaling pathway" "Estrogen-dependent gene expression; Potential therapeutics for SARS; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase" "6" "0" "0.951" "0.984" "0.977" "0.985" "0.945" "0.976" "0.973" "0.955" "0.960" "5025.0" "4780.8" "4947.0" "4911.0" "4947.1" "4748.9" "4903.3" "4887.5" "4798.4" "4823.4" "" "" "" "" "" "" "" "" "" "" "4708.4" "3956.0" "4592.7" "3796.4" "4216.8" "4537.1" "4480.4" "4339.6" "4798.4" "4644.3" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8390687985957490189" "False" "High" "IsMasterProtein" "Q5VTR2" "E3 ubiquitin-protein ligase BRE1A OS=Homo sapiens OX=9606 GN=RNF20 PE=1 SV=2" "0.000" "False" "68.493" "23" "19" "24" "17" "975" "113.6" "5.94" "84.37" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097" "56254" "ENSG00000155827" "RNF20" "A7MCT5; hsa:56254; Q2TB34; Q5VTR2; Q69YL5; Q6P527; Q8N3J4; Q96JD3; Q9H9Y7; Q9HA51; Q9NUR4; Q9NWQ3; Q9NX83" "ATM signaling in development and disease" "E3 ubiquitin ligases ubiquitinate target proteins; RHOBTB1 GTPase cycle" "3" "0" "0.996" "0.996" "1.050" "1.035" "1.025" "1.017" "1.019" "1.005" "1.025" "2518.1" "2507.6" "2508.7" "2644.6" "2606.4" "2581.8" "2560.4" "2565.5" "2531.2" "2580.2" "" "" "" "" "" "" "" "" "" "" "2359.5" "2075.0" "2329.0" "2044.4" "2221.6" "2466.6" "2339.6" "2277.9" "2531.2" "2484.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "338610440228744590" "False" "High" "IsMasterProtein" "Q13620" "Cullin-4B OS=Homo sapiens OX=9606 GN=CUL4B PE=1 SV=4" "0.000" "False" "68.411" "22" "23" "31" "14" "913" "103.9" "7.37" "94.74" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8450" "ENSG00000158290" "CUL4B" "B1APK5; B3KVX4; B7Z5K8; hsa:8450; Q13620; Q6PIE4; Q6UP07; Q7Z673; Q9BY37; Q9UEB7; Q9UED7" "Mesodermal commitment pathway; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER; Dual Incision in GG-NER" "13" "7" "0.963" "0.987" "0.959" "0.964" "0.972" "0.972" "0.932" "0.977" "0.986" "3357.5" "3233.1" "3313.5" "3219.3" "3238.2" "3265.0" "3264.2" "3130.8" "3280.2" "3309.6" "" "" "" "" "" "" "" "" "" "" "3146.0" "2675.4" "3076.2" "2488.7" "2760.1" "3119.4" "2982.6" "2779.8" "3280.2" "3186.7" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9100750251972445181" "False" "High" "IsMasterProtein" "Q14C86" "GTPase-activating protein and VPS9 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GAPVD1 PE=1 SV=2" "0.000" "False" "68.289" "17" "23" "27" "23" "1478" "164.9" "5.22" "88.98" "23" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00616, Pf02204, Pf18151" "26130" "ENSG00000165219" "GAPVD1" "A8MYK3; B0QZ62; B0QZ63; B0QZ64; hsa:26130; Q14C76; Q14C86; Q2Q1W1; Q8ND92; Q8WU86; Q96CZ4; Q9NXQ1; Q9P207; Q9Y4N0" "" "RAB GEFs exchange GTP for GDP on RABs; Clathrin-mediated endocytosis" "2" "0" "0.992" "1.014" "1.032" "1.036" "1.048" "0.996" "0.953" "0.993" "1.025" "1962.2" "1946.6" "1989.9" "2024.9" "2032.1" "2055.6" "1955.2" "1870.3" "1948.3" "2012.0" "" "" "" "" "" "" "" "" "" "" "1838.5" "1610.8" "1847.4" "1565.4" "1732.1" "1963.9" "1786.6" "1660.6" "1948.3" "1937.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8375301801822560127" "False" "High" "IsMasterProtein" "P36776" "Lon protease homolog, mitochondrial OS=Homo sapiens OX=9606 GN=LONP1 PE=1 SV=2" "0.000" "False" "68.159" "26" "21" "33" "21" "959" "106.4" "6.39" "108.39" "21" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00004, Pf02190, Pf05362" "9361" "ENSG00000196365" "LONP1" "B3KPH8; D6W635; E5KMH8; F5GZ27; hsa:9361; P36776; P36777; Q8N8K8; Q9UQ95" "" "Mitochondrial protein degradation" "1" "0" "0.968" "1.042" "0.972" "1.029" "1.036" "0.982" "1.016" "1.044" "1.020" "4037.9" "3910.3" "4207.7" "3925.5" "4153.4" "4181.9" "3966.9" "4102.2" "4216.5" "4118.4" "" "" "" "" "" "" "" "" "" "" "3783.5" "3235.7" "3906.3" "3034.6" "3540.2" "3995.4" "3624.6" "3642.3" "4216.5" "3965.4" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3588526575422441763" "False" "High" "IsMasterProtein" "P42285" "Exosome RNA helicase MTR4 OS=Homo sapiens OX=9606 GN=MTREX PE=1 SV=3" "0.000" "False" "68.039" "18" "20" "31" "20" "1042" "117.7" "6.52" "94.11" "20" "RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf08148, Pf13234, Pf21408" "23517" "ENSG00000039123" "MTREX" "hsa:23517; P42285; Q2M386; Q6MZZ8; Q6P170; Q8N5R0; Q8TAG2" "" "mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol" "2" "0" "0.981" "1.031" "1.030" "1.033" "1.028" "1.045" "1.065" "1.030" "1.019" "4460.0" "4377.4" "4599.8" "4594.4" "4608.1" "4586.4" "4661.6" "4747.8" "4592.6" "4544.8" "" "" "" "" "" "" "" "" "" "" "4179.0" "3622.2" "4270.3" "3551.7" "3927.8" "4381.9" "4259.4" "4215.6" "4592.6" "4376.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6400995593712089390" "False" "High" "IsMasterProtein" "Q9NYU2" "UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3" "0.000" "False" "67.882" "13" "22" "39" "22" "1555" "177.1" "5.63" "112.87" "22" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf06427, Pf18400, Pf18401, Pf18402, Pf18403, Pf18404" "56886" "ENSG00000136731" "UGGT1" "hsa:56886; Q53QP2; Q53SL3; Q8IW30; Q9H8I4; Q9NYU2" "IL-18 signaling pathway" "ER Quality Control Compartment (ERQC)" "2" "0" "0.961" "1.020" "0.990" "1.012" "1.006" "0.982" "0.993" "0.967" "0.993" "3046.9" "2929.3" "3106.7" "3015.9" "3082.3" "3064.8" "2992.9" "3025.3" "2945.2" "3024.5" "" "" "" "" "" "" "" "" "" "" "2855.0" "2424.0" "2884.2" "2331.4" "2627.3" "2928.2" "2734.7" "2686.2" "2945.2" "2912.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7989790464056543145" "False" "High" "IsMasterProtein" "Cont_P35527" "Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3" "0.000" "True" "67.827" "33" "18" "33" "17" "623" "62.0" "5.24" "111.60" "18" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00038" "3857; 454664" "ENSG00000171403; ENSPTRG00000009169" "KRT9" "A0A2J8KG96; A0A6D2VYW7; H2QCZ6; hsa:3857; O00109; P35527; ptr:454664; Q0IJ47; Q14665" "" "Formation of the cornified envelope" "2" "0" "0.596" "0.266" "0.304" "0.330" "0.395" "3.202" "0.626" "0.156" "0.557" "6040.1" "3601.7" "1607.6" "1835.3" "1994.5" "2385.5" "19341.2" "3779.3" "941.4" "3362.8" "" "" "" "" "" "" "" "" "" "" "5659.6" "2980.4" "1492.4" "1418.7" "1700.0" "2279.2" "17672.7" "3355.7" "941.4" "3237.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8732346175470674622" "False" "High" "IsMasterProtein" "Q86UP2" "Kinectin OS=Homo sapiens OX=9606 GN=KTN1 PE=1 SV=1" "0.000" "False" "67.766" "17" "24" "27" "24" "1357" "156.2" "5.64" "77.34" "24" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi" "cytoskeletal activity" "Pf05104" "3895" "ENSG00000126777" "KTN1" "B4DZ88; hsa:3895; Q13999; Q14707; Q15387; Q17RZ5; Q5GGW3; Q86UP2; Q86W57" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "CDC42 GTPase cycle; RAC1 GTPase cycle; RND2 GTPase cycle; RND3 GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; RHO GTPases activate KTN1" "11" "0" "1.001" "0.993" "1.116" "1.147" "1.178" "1.398" "1.374" "1.384" "1.180" "1536.2" "1537.5" "1526.1" "1714.9" "1761.9" "1809.6" "2147.0" "2111.0" "2126.0" "1812.8" "" "" "" "" "" "" "" "" "" "" "1439.5" "1272.3" "1416.8" "1325.7" "1501.8" "1728.9" "1961.8" "1874.4" "2126.0" "1745.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8408211072324921186" "False" "High" "IsMasterProtein" "P78344" "Eukaryotic translation initiation factor 4 gamma 2 OS=Homo sapiens OX=9606 GN=EIF4G2 PE=1 SV=1" "0.000" "False" "67.629" "25" "23" "30" "23" "907" "102.3" "7.14" "96.24" "23" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf02020, Pf02847, Pf02854" "1982" "ENSG00000110321" "EIF4G2" "hsa:1982; O60877; P78344; P78404; Q0VH00; Q0VH01; Q2NKW9; Q49A79; Q53EU1; Q58EZ2; Q8NI71; Q96C16" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation; Acute viral myocarditis" "ISG15 antiviral mechanism" "4" "0" "1.030" "1.021" "1.020" "1.048" "1.060" "1.049" "1.060" "1.045" "1.047" "3488.1" "3593.9" "3562.6" "3558.8" "3655.8" "3695.9" "3660.5" "3696.3" "3644.5" "3653.7" "" "" "" "" "" "" "" "" "" "" "3268.4" "2973.9" "3307.4" "2751.1" "3116.1" "3531.1" "3344.7" "3281.9" "3644.5" "3518.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9022416781062355686" "False" "High" "IsMasterProtein" "Q9UPU5" "Ubiquitin carboxyl-terminal hydrolase 24 OS=Homo sapiens OX=9606 GN=USP24 PE=1 SV=3" "0.000" "False" "67.627" "9" "24" "28" "24" "2620" "294.2" "6.14" "91.21" "24" "protein metabolism" "cytosol;nucleus" "other molecular function" "Pf00443" "23358" "ENSG00000162402" "USP24" "hsa:23358; Q6ZSY2; Q8N2Y4; Q9NXD1; Q9UPU5" "" "Ub-specific processing proteases" "1" "0" "0.991" "1.016" "1.014" "1.006" "1.021" "1.045" "0.998" "0.999" "1.033" "3513.5" "3483.2" "3571.1" "3561.5" "3534.7" "3585.8" "3672.3" "3506.4" "3509.5" "3630.4" "" "" "" "" "" "" "" "" "" "" "3292.1" "2882.3" "3315.3" "2753.2" "3012.9" "3425.9" "3355.5" "3113.4" "3509.5" "3495.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2100878916131084887" "False" "High" "IsMasterProtein" "P36871" "Phosphoglucomutase-1 OS=Homo sapiens OX=9606 GN=PGM1 PE=1 SV=3" "0.000" "False" "67.548" "38" "20" "41" "20" "562" "61.4" "6.76" "125.75" "20" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf02878, Pf02879, Pf02880" "5236" "ENSG00000079739" "PGM1" "B2R5N9; B4DPV0; hsa:5236; P36871; Q16105; Q16106; Q5BKZ9; Q6NW22; Q86U74; Q96J40; Q9NTY4" "Ectoderm differentiation; Clear cell renal cell carcinoma pathways; Glycogen synthesis and degradation; Opioid receptor pathways; Disorders of galactose metabolism ; Disorders of fructose metabolism; UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "Neutrophil degranulation; Glycogen synthesis; Glycogen breakdown (glycogenolysis); Galactose catabolism; Defective PGM1 causes PGM1-CDG" "13" "0" "0.935" "0.950" "0.922" "0.938" "0.944" "0.891" "0.941" "0.964" "0.957" "4081.2" "3814.8" "3878.7" "3761.3" "3827.6" "3852.0" "3636.6" "3838.5" "3933.8" "3906.0" "" "" "" "" "" "" "" "" "" "" "3824.1" "3156.7" "3600.9" "2907.7" "3262.5" "3680.2" "3322.8" "3408.2" "3933.8" "3760.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1047119725647514999" "False" "High" "IsMasterProtein" "P23588" "Eukaryotic translation initiation factor 4B OS=Homo sapiens OX=9606 GN=EIF4B PE=1 SV=2" "0.000" "False" "67.542" "33" "22" "40" "22" "611" "69.1" "5.73" "121.80" "22" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "nucleic acid binding activity" "Pf00076" "1975" "ENSG00000063046" "EIF4B" "B4DS13; hsa:1975; P23588; Q4G0E3; Q53HQ2; Q6GPH5; Q6IB46; Q8WYK5" "Translation factors; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; Interferon type I signaling pathways" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "16" "0" "1.028" "1.028" "1.025" "1.003" "0.982" "0.998" "0.960" "0.960" "0.972" "4968.8" "5108.0" "5108.8" "5091.9" "4984.1" "4879.2" "4960.3" "4771.5" "4769.9" "4829.0" "" "" "" "" "" "" "" "" "" "" "4655.8" "4226.8" "4742.8" "3936.3" "4248.3" "4661.6" "4532.4" "4236.6" "4769.9" "4649.7" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-566189082840404496" "False" "High" "IsMasterProtein" "Q8WVM7" "Cohesin subunit SA-1 OS=Homo sapiens OX=9606 GN=STAG1 PE=1 SV=3" "0.000" "False" "67.514" "18" "22" "29" "16" "1258" "144.3" "5.59" "94.07" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08514, Pf21581" "10274" "ENSG00000118007" "STAG1" "hsa:10274; O00539; Q6P275; Q8WVM7" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; 10q22q23 copy number variation" "Meiotic synapsis; Estrogen-dependent gene expression; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "10" "5" "0.989" "1.008" "1.038" "0.997" "0.986" "1.024" "0.991" "1.006" "1.011" "2681.3" "2652.6" "2702.4" "2784.1" "2673.4" "2644.5" "2744.8" "2656.4" "2696.1" "2711.7" "" "" "" "" "" "" "" "" "" "" "2512.4" "2195.0" "2508.8" "2152.2" "2278.7" "2526.6" "2508.0" "2358.6" "2696.1" "2610.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4287058177622287432" "False" "High" "IsMasterProtein" "O95757" "Heat shock 70 kDa protein 4L OS=Homo sapiens OX=9606 GN=HSPA4L PE=1 SV=3" "0.000" "False" "67.083" "29" "22" "33" "20" "839" "94.5" "5.88" "101.32" "22" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00012" "22824" "ENSG00000164070" "HSPA4L" "A2ICT2; hsa:22824; O95757; Q4W5M5; Q8IWA2" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "1.037" "1.009" "1.045" "1.019" "0.999" "0.967" "1.002" "1.003" "1.020" "3505.2" "3636.4" "3535.3" "3663.9" "3572.0" "3501.2" "3391.1" "3513.4" "3516.8" "3576.9" "" "" "" "" "" "" "" "" "" "" "3284.4" "3009.1" "3282.1" "2832.4" "3044.7" "3345.0" "3098.6" "3119.6" "3516.8" "3444.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7845595134204648988" "False" "High" "IsMasterProtein" "Q8NE71" "ATP-binding cassette sub-family F member 1 OS=Homo sapiens OX=9606 GN=ABCF1 PE=1 SV=2" "0.000" "False" "66.940" "26" "19" "32" "19" "845" "95.9" "6.80" "107.03" "19" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00005" "23" "ENSG00000204574; ENSG00000206490; ENSG00000225989; ENSG00000231129; ENSG00000232169; ENSG00000236149; ENSG00000236342" "ABCF1" "A2BF75; hsa:23; O14897; Q69YP6; Q8NE71" "IL-18 signaling pathway" "ABC-family proteins mediated transport" "2" "0" "0.965" "1.049" "0.961" "0.970" "0.962" "0.947" "0.949" "0.970" "0.979" "4029.4" "3889.0" "4226.2" "3870.6" "3909.9" "3874.5" "3815.8" "3825.1" "3907.0" "3943.8" "" "" "" "" "" "" "" "" "" "" "3775.6" "3218.1" "3923.4" "2992.1" "3332.7" "3701.7" "3486.6" "3396.3" "3907.0" "3797.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "964900113043376779" "False" "High" "IsMasterProtein" "Q9Y265" "RuvB-like 1 OS=Homo sapiens OX=9606 GN=RUVBL1 PE=1 SV=1" "0.000" "False" "66.654" "45" "17" "25" "17" "456" "50.2" "6.42" "92.25" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06068, Pf17856" "8607" "ENSG00000175792" "RUVBL1" "B2R5S0; hsa:8607; P82276; Q1KMR0; Q53HK5; Q53HL7; Q53Y27; Q9BSX9; Q9Y265" "Gastric cancer network 1; lncRNA in canonical Wnt signaling and colorectal cancer" "Formation of the beta-catenin:TCF transactivating complex; Ub-specific processing proteases; UCH proteinases; Deposition of new CENPA-containing nucleosomes at the centromere; Telomere Extension By Telomerase; HATs acetylate histones; DNA Damage Recognition in GG-NER" "9" "0" "0.999" "0.982" "0.970" "0.989" "0.957" "0.945" "0.968" "0.956" "0.984" "3104.2" "3102.3" "3047.7" "3012.4" "3068.7" "2970.9" "2933.7" "3006.2" "2966.3" "3054.3" "" "" "" "" "" "" "" "" "" "" "2908.6" "2567.1" "2829.4" "2328.7" "2615.7" "2838.4" "2680.6" "2669.2" "2966.3" "2940.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5845152794455651809" "False" "High" "IsMasterProtein" "O75179" "Ankyrin repeat domain-containing protein 17 OS=Homo sapiens OX=9606 GN=ANKRD17 PE=1 SV=3" "0.000" "False" "66.653" "8" "18" "28" "11" "2603" "274.1" "6.52" "78.00" "18" "stress response;developmental processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf00013, Pf12796, Pf13637" "26057" "ENSG00000132466" "ANKRD17" "E7EUV3; G5E964; hsa:26057; O75179; Q6PJ85; Q6PK85; Q6PKA2; Q86XI3; Q8NDR5; Q96I86; Q9H288; Q9H6J9" "" "" "0" "0" "1.060" "1.009" "1.078" "1.060" "0.986" "1.010" "0.984" "0.958" "1.026" "1177.7" "1248.4" "1187.8" "1270.1" "1247.9" "1161.2" "1189.4" "1158.8" "1128.8" "1207.8" "" "" "" "" "" "" "" "" "" "" "1103.5" "1033.1" "1102.8" "981.8" "1063.6" "1109.4" "1086.8" "1028.9" "1128.8" "1162.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8785242188080332383" "False" "High" "IsMasterProtein" "P28838" "Cytosol aminopeptidase OS=Homo sapiens OX=9606 GN=LAP3 PE=1 SV=3" "0.000" "False" "66.585" "39" "18" "33" "18" "519" "56.1" "7.93" "90.19" "18" "protein metabolism" "other cell component" "other molecular function" "Pf00883, Pf02789" "51056" "ENSG00000002549" "LAP3" "B3KMQ3; hsa:51056; P28838; Q6IAM6; Q6P0L6; Q9UQE3" "" "" "0" "0" "0.976" "0.928" "1.003" "0.936" "1.006" "0.947" "0.973" "1.021" "0.968" "1990.4" "1941.8" "1846.2" "1996.9" "1863.5" "2002.9" "1884.7" "1936.4" "2032.8" "1926.8" "" "" "" "" "" "" "" "" "" "" "1865.0" "1606.8" "1713.9" "1543.7" "1588.4" "1913.6" "1722.1" "1719.3" "2032.8" "1855.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3028691531671689044" "False" "High" "IsMasterProtein" "Q14697" "Neutral alpha-glucosidase AB OS=Homo sapiens OX=9606 GN=GANAB PE=1 SV=3" "0.000" "False" "66.582" "23" "21" "46" "21" "944" "106.8" "6.14" "157.24" "21" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf01055, Pf13802, Pf21365" "23193" "ENSG00000089597" "GANAB" "A6NC20; hsa:23193; Q14697; Q8WTS9; Q9P0X0" "N-glycan biosynthesis" "Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "5" "0" "0.955" "0.983" "0.944" "0.921" "0.959" "0.913" "0.951" "0.955" "0.943" "6436.6" "6147.5" "6325.3" "6075.0" "5929.3" "6169.5" "5877.8" "6120.3" "6147.1" "6072.1" "" "" "" "" "" "" "" "" "" "" "6031.1" "5087.0" "5872.3" "4696.3" "5054.0" "5894.4" "5370.8" "5434.2" "6147.1" "5846.5" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8769135798573244061" "False" "High" "IsMasterProtein" "P35658" "Nuclear pore complex protein Nup214 OS=Homo sapiens OX=9606 GN=NUP214 PE=1 SV=2" "0.000" "False" "66.426" "11" "21" "25" "21" "2090" "213.5" "7.47" "85.69" "21" "other metabolic processes;transport;other biological processes" "cytosol;nucleus" "other molecular function" "Pf18617" "8021" "ENSG00000126883" "NUP214" "A6NFQ0; hsa:8021; P35658; Q15010; Q3KQZ0; Q5JUP7; Q75R47; Q86XD3" "TGF-beta signaling pathway" "SUMOylation of DNA replication proteins; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HuR (ELAVL1) binds and stabilizes mRNA" "30" "0" "1.001" "1.022" "1.016" "1.042" "1.005" "0.997" "1.007" "1.040" "1.037" "3597.7" "3602.3" "3675.6" "3656.0" "3748.2" "3614.9" "3586.4" "3623.7" "3743.0" "3730.5" "" "" "" "" "" "" "" "" "" "" "3371.0" "2980.8" "3412.3" "2826.2" "3194.9" "3453.7" "3277.0" "3217.5" "3743.0" "3591.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-469021931412063719" "False" "High" "IsMasterProtein" "P53618" "Coatomer subunit beta OS=Homo sapiens OX=9606 GN=COPB1 PE=1 SV=3" "0.000" "False" "66.328" "23" "19" "30" "19" "953" "107.1" "6.05" "81.31" "19" "transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01602, Pf07718, Pf14806" "1315" "ENSG00000129083" "COPB1" "D3DQX0; hsa:1315; P53618; Q6GTT7; Q9NTK2; Q9UNW7" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Neutrophil degranulation" "3" "0" "0.945" "1.026" "0.951" "0.962" "0.961" "0.944" "0.943" "0.946" "0.951" "3349.2" "3163.7" "3435.2" "3185.2" "3220.7" "3217.1" "3163.0" "3157.8" "3167.1" "3184.4" "" "" "" "" "" "" "" "" "" "" "3138.2" "2618.0" "3189.2" "2462.3" "2745.2" "3073.6" "2890.1" "2803.8" "3167.1" "3066.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5165886701298417594" "False" "High" "IsMasterProtein" "Q15459" "Splicing factor 3A subunit 1 OS=Homo sapiens OX=9606 GN=SF3A1 PE=1 SV=1" "0.000" "False" "66.155" "27" "21" "31" "21" "793" "88.8" "5.22" "100.41" "21" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00240, Pf01805, Pf12230" "10291" "ENSG00000099995" "SF3A1" "E9PAW1; hsa:10291; Q15459" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.934" "1.004" "1.008" "1.010" "1.033" "1.068" "1.109" "1.063" "1.015" "2788.9" "2605.4" "2800.2" "2812.5" "2818.2" "2882.0" "2977.7" "3093.6" "2965.4" "2829.9" "" "" "" "" "" "" "" "" "" "" "2613.2" "2156.0" "2599.7" "2174.2" "2402.1" "2753.5" "2720.8" "2746.8" "2965.4" "2724.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2537127350626285919" "False" "High" "IsMasterProtein" "P49959" "Double-strand break repair protein MRE11 OS=Homo sapiens OX=9606 GN=MRE11 PE=1 SV=3" "0.000" "False" "66.094" "29" "20" "31" "20" "708" "80.5" "5.90" "97.48" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00149, Pf04152" "4361" "ENSG00000020922" "MRE11" "B3KTC7; hsa:4361; O43475; P49959" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; Breast cancer pathway; Joubert syndrome; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Neurogenesis regulation in the olfactory epithelium; DNA damage response" "Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Cytosolic sensors of pathogen-associated DNA ; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks; IRF3-mediated induction of type I IFN" "31" "0" "0.981" "0.994" "0.962" "1.009" "0.986" "0.993" "0.996" "0.976" "0.996" "3333.5" "3270.9" "3312.0" "3206.8" "3365.1" "3287.3" "3311.4" "3319.7" "3251.8" "3321.2" "" "" "" "" "" "" "" "" "" "" "3123.5" "2706.6" "3074.8" "2479.0" "2868.3" "3140.7" "3025.7" "2947.6" "3251.8" "3197.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2254798804738061271" "False" "High" "IsMasterProtein" "O60271" "C-Jun-amino-terminal kinase-interacting protein 4 OS=Homo sapiens OX=9606 GN=SPAG9 PE=1 SV=4" "0.000" "False" "66.023" "18" "21" "26" "21" "1321" "146.1" "5.15" "89.09" "21" "transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf09744, Pf16471, Pf19056" "9043" "ENSG00000008294" "SPAG9" "A6H8U5; A8MSX0; B4DHH2; hsa:9043; O60271; O60905; Q3KQU8; Q3MKM7; Q86WC7; Q86WC8; Q8IZX7; Q96II0; Q9H811" "" "Myogenesis" "1" "0" "0.976" "0.998" "0.949" "0.945" "0.948" "0.928" "0.956" "0.925" "0.977" "3608.4" "3523.2" "3602.2" "3425.8" "3409.3" "3419.0" "3348.3" "3449.7" "3339.4" "3525.4" "" "" "" "" "" "" "" "" "" "" "3381.1" "2915.4" "3344.2" "2648.3" "2906.0" "3266.5" "3059.4" "3063.0" "3339.4" "3394.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5003304044033613110" "False" "High" "IsMasterProtein" "O43175" "D-3-phosphoglycerate dehydrogenase OS=Homo sapiens OX=9606 GN=PHGDH PE=1 SV=4" "0.000" "False" "65.970" "34" "15" "43" "15" "533" "56.6" "6.71" "157.33" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00389, Pf02826, Pf19304" "26227" "ENSG00000092621" "PHGDH" "B2RD08; hsa:26227; O43175; Q5SZU3; Q9BQ01" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "Serine biosynthesis" "5" "0" "0.937" "0.978" "0.978" "0.955" "0.946" "0.923" "0.924" "0.936" "0.956" "5523.5" "5176.2" "5402.0" "5403.6" "5272.9" "5225.1" "5098.4" "5101.3" "5168.2" "5281.9" "" "" "" "" "" "" "" "" "" "" "5175.5" "4283.2" "5015.0" "4177.2" "4494.5" "4992.1" "4658.6" "4529.4" "5168.2" "5085.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2726683976815450871" "False" "High" "IsMasterProtein" "P00338" "L-lactate dehydrogenase A chain OS=Homo sapiens OX=9606 GN=LDHA PE=1 SV=2" "0.000" "False" "65.908" "41" "15" "82" "13" "332" "36.7" "8.27" "234.29" "15" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "3939" "ENSG00000134333; ENSG00000288299" "LDHA" "B4DKQ2; B7Z5E3; D3DQY3; F8W819; hsa:3939; P00338; Q53G53; Q6IBM7; Q6ZNV1; Q9UDE8; Q9UDE9" "Cori cycle; HIF1A and PPARG regulation of glycolysis; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Amino acid metabolism; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Orexin receptor pathway; CCL18 signaling pathway; Glucose metabolism in triple-negative breast cancer cells; Warburg effect modulated by deubiquitinating enzymes and their substrates; Lactate shuttle in glial cells; Glycolysis and gluconeogenesis; Macrophage-stimulating protein (MSP) signaling network map; Metabolic Epileptic Disorders" "Pyruvate metabolism" "20" "2" "0.963" "0.985" "1.008" "0.932" "0.949" "0.948" "0.959" "0.983" "0.949" "5434.3" "5235.1" "5355.1" "5479.2" "5065.2" "5158.9" "5154.4" "5211.5" "5342.6" "5155.3" "" "" "" "" "" "" "" "" "" "" "5092.0" "4332.0" "4971.5" "4235.6" "4317.4" "4928.9" "4709.8" "4627.3" "5342.6" "4963.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8788439396421035672" "False" "High" "IsMasterProtein" "Q92621" "Nuclear pore complex protein Nup205 OS=Homo sapiens OX=9606 GN=NUP205 PE=1 SV=3" "0.000" "False" "65.884" "10" "21" "28" "21" "2012" "227.8" "6.19" "84.31" "21" "cell organization and biogenesis;transport" "other membranes;cytosol;nucleus" "other molecular function" "Pf11894" "23165" "ENSG00000155561" "NUP205" "A6H8X3; hsa:23165; Q86YC1; Q92621" "" "SUMOylation of DNA replication proteins; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "29" "0" "1.019" "1.044" "1.057" "1.077" "1.052" "1.063" "1.085" "1.023" "1.041" "2404.9" "2450.5" "2510.9" "2541.2" "2589.4" "2529.1" "2556.8" "2610.3" "2460.1" "2503.9" "" "" "" "" "" "" "" "" "" "" "2253.4" "2027.8" "2331.0" "1964.5" "2207.2" "2416.3" "2336.2" "2317.7" "2460.1" "2410.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5521793610303513807" "False" "High" "IsMasterProtein" "P52789" "Hexokinase-2 OS=Homo sapiens OX=9606 GN=HK2 PE=1 SV=2" "0.000" "False" "65.855" "25" "20" "26" "18" "917" "102.3" "6.05" "85.80" "20" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00349, Pf03727" "3099" "ENSG00000159399" "HK2" "D6W5J2; hsa:3099; P52789; Q8WU87; Q9UN82" "Clear cell renal cell carcinoma pathways; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Macrophage-stimulating protein (MSP) signaling network map; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts" "Glycolysis" "7" "0" "0.977" "1.066" "1.000" "1.038" "0.991" "1.001" "1.007" "1.026" "1.039" "1940.7" "1896.3" "2068.6" "1940.5" "2015.1" "1923.4" "1943.4" "1953.9" "1991.9" "2016.5" "" "" "" "" "" "" "" "" "" "" "1818.4" "1569.1" "1920.4" "1500.1" "1717.6" "1837.7" "1775.8" "1734.8" "1991.9" "1941.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6737848688669361571" "False" "High" "IsMasterProtein" "Q9UNZ2" "NSFL1 cofactor p47 OS=Homo sapiens OX=9606 GN=NSFL1C PE=1 SV=2" "0.000" "False" "65.639" "51" "16" "27" "16" "370" "40.5" "5.10" "102.54" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00789, Pf08059, Pf14555" "55968" "ENSG00000088833" "NSFL1C" "A2A2L1; B2RD74; hsa:55968; Q5JXA4; Q5JXA5; Q7Z533; Q9H102; Q9NVL9; Q9UI06; Q9UNZ2" "Alstrom syndrome" "RHOH GTPase cycle" "2" "0" "1.046" "1.008" "0.993" "1.033" "1.042" "0.985" "1.062" "1.009" "1.036" "2768.9" "2897.1" "2790.9" "2750.9" "2861.6" "2884.5" "2728.5" "2941.1" "2794.7" "2869.1" "" "" "" "" "" "" "" "" "" "" "2594.5" "2397.3" "2591.0" "2126.6" "2439.2" "2755.8" "2493.1" "2611.4" "2794.7" "2762.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3614500297026839647" "False" "High" "IsMasterProtein" "Q9Y266" "Nuclear migration protein nudC OS=Homo sapiens OX=9606 GN=NUDC PE=1 SV=1" "0.000" "False" "65.586" "58" "18" "37" "18" "331" "38.2" "5.38" "119.22" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04969, Pf14050, Pf16273" "10726" "ENSG00000090273" "NUDC" "hsa:10726; Q5QP31; Q5QP35; Q9H0N2; Q9Y266; Q9Y2B6" "Ciliary landscape; PAFAH1B1 copy number variation" "RND2 GTPase cycle; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "9" "0" "0.993" "0.961" "0.965" "0.988" "0.996" "0.930" "0.949" "0.935" "0.952" "5328.9" "5291.5" "5120.7" "5140.9" "5264.2" "5308.6" "4953.9" "5058.8" "4981.2" "5072.5" "" "" "" "" "" "" "" "" "" "" "4993.2" "4378.6" "4754.0" "3974.2" "4487.0" "5071.9" "4526.6" "4491.7" "4981.2" "4884.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3249429330709182822" "False" "High" "IsMasterProtein" "Cont_P68138" "Actin, alpha skeletal muscle OS=Bos taurus OX=9913 GN=ACTA1 PE=1 SV=1" "0.000" "True" "65.544" "34" "12" "123" "2" "377" "42.0" "5.39" "364.83" "12" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "100065454; 100154254; 100172818; 100395910; 100426612; 100542212; 100566789; 100609865; 100661558; 100716933; 100926492; 100955023; 100987270; 101018268; 101107662; 101316902; 101345310; 101371004; 101561057; 101607063; 101822895; 101878061; 101942538; 101972057; 102017886; 102121165; 102446120; 102836098; 102922102; 102943964; 103051164; 103127961; 103195041; 103624093; 103744113; 103818506; 104131026; 104291844; 104300855; 104488844; 104860683; 104987264; 105499142; 105505494; 105722343; 105823179; 105871143; 106543751; 106843698; 108498591; 108537854; 109248958; 109372851; 109689807; 11459; 281592; 29437; 58" "ENSABRG00000018240; ENSACAG00000001104; ENSACCG00020004955; ENSACDG00005004064; ENSACOG00000015573; ENSAMEG00000005186; ENSANAG00000033052; ENSANIG00000015411; ENSAOWG00000018027; ENSAPLG00000004146; ENSAPLG00020002125; ENSBGRG00000020862; ENSBIXG00000012362; ENSBIXG00005025901; ENSBMSG00010014761; ENSBTAG00000046332; ENSCABG00000013181; ENSCAFG00000008253; ENSCAFG00020027254; ENSCAFG00030012637; ENSCANG00000033017; ENSCCAG00000035682; ENSCCNG00000030664; ENSCGRG00001016859; ENSCJAG00000011114; ENSCLAG00000003307; ENSCMMG00000014710; ENSCMUG00000000473; ENSCPBG00000006129; ENSCPGG00000000824; ENSCPIG00010005220; ENSCPOG00000032187; ENSCPVG00000014620; ENSCSRG00000013784; ENSCUSG00005000547; ENSCWAG00000013028; ENSDLEG00000008382; ENSDNVG00000014331; ENSEASG00005031337; ENSEGOG00005009171; ENSFCAG00000030433; ENSFDAG00000018383; ENSFTIG00000004572; ENSG00000143632; ENSGAGG00000007922; ENSGEVG00005016044; ENSJHYG00000007552; ENSJJAG00000019369; ENSLAFG00000006306; ENSLCNG00005015654; ENSLLTG00000003642; ENSMCSG00000014926; ENSMFAG00000002280; ENSMGAG00000012010; ENSMICG00000007460; ENSMMNG00015014953; ENSMMSG00000010015; ENSMMUG00000022086; ENSMNEG00000003684; ENSMSIG00000009031; ENSMUNG00000016766; ENSMUSG00000031972; ENSNGAG00000008844; ENSNVIG00000023437; ENSOANG00000012845; ENSOARG00000003044; ENSOGAG00000016005; ENSOSUG00000015814; ENSPANG00000005524; ENSPCEG00000011384; ENSPCLG00000000773; ENSPCOG00000022008; ENSPCTG00005016061; ENSPEMG00000019882; ENSPLOG00000020512; ENSPMRG00000005431; ENSPPAG00000033916; ENSPPYG00000000127; ENSPSIG00000002854; ENSPSNG00000011648; ENSPSTG00000017705; ENSPTRG00000002086; ENSRBIG00000037124; ENSRFEG00010013727; ENSRNOG00000017786; ENSRNOG00055021900; ENSRNOG00060017592; ENSRNOG00065018197; ENSSCAG00000003577; ENSSHAG00000014035; ENSSHBG00005006730; ENSSMRG00000022024; ENSSOCG00000011564; ENSSSCG00000010190; ENSSSCG00015047339; ENSSSCG00040044916; ENSSSCG00055024685; ENSSSCG00065076746; ENSSSUG00005003524; ENSSTOG00000024222; ENSSVLG00005008349; ENSTGEG00000010273; ENSTGUG00000010041; ENSUAMG00000015031; ENSUPAG00010000311; ENSVKKG00000017431; ENSVURG00010000907; ENSVURG00010001203" "Acta1; ACTA1; LOC101345310; LOC101878061; LOC103127961; LOC103661861; LOC111160482; LOC112807841" "A0A090BWQ4; A0A091DQ28; A0A091EBT4; A0A091GSF2; A0A091GVU0; A0A091JKH4; A0A093GLM6; A0A096N2Y2; A0A098M1X6; A0A0A0AU99; A0A1S3APV3; A0A1U7QEW4; A0A1W7RJM3; A0A218VBM4; A0A226MSL5; A0A250XZP0; A0A2I0UAK3; A0A2J8M6H1; A0A2J8R810; A0A2K5EBS2; A0A2K5IRF2; A0A2K5S578; A0A2K5TYP0; A0A2K6ANM2; A0A2K6G1G8; A0A2K6LSJ0; A0A2P4SXB1; A0A2R9AZU8; A0A2U3W9D6; A0A2U4BVD6; A0A2Y9E0P7; A0A2Y9HE43; A0A2Y9L6W7; A0A2Y9LGX2; A0A2Y9S7L7; A0A3L7I1B1; A0A3L8S8G5; A0A3M0KHK7; A0A3Q7NT51; A0A452H615; A0A452RJE1; A0A480QNI6; A0A4U1EEU3; A0A4W2GZT5; A0A4X2JWN6; A0A5J5MT96; A0A5N3VLN8; A0A663E501; A0A667HAA9; A0A669PGX8; A0A670I895; A0A671F3Z0; A0A672U2N2; A0A673SW94; A0A6B2F569; A0A6B2F5D9; A0A6D2XHK8; A0A6I9M0F0; A0A6I9XXG7; A0A6J0HG37; A0A6J0T852; A0A6J1U9U4; A0A6J1YDW3; A0A6J2GP26; A0A6J2NA43; A0A6J3CTV5; A0A6J3EY96; A0A6P3ERW2; A0A6P3FJ88; A0A6P3HAS4; A0A6P5LDM6; A0A6P9CIM0; A0A6P9EZA5; A0A7J7EZ09; A0A7J7RJI6; A0A7J7RTV4; A0A7J8B841; A0A7J8BL15; A0A7K4JPE4; A0A7K4PSI7; A0A7K4QY10; A0A7K4RLR4; A0A7K4UDE9; A0A7K4UY42; A0A7K4W696; A0A7K4XA22; A0A7K4Y8W8; A0A7K4ZFF1; A0A7K5BDX3; A0A7K5D428; A0A7K5GNW3; A0A7K5HRK1; A0A7K5IK78; A0A7K5JXK4; A0A7K5KX43; A0A7K5MSI7; A0A7K5NP28; A0A7K5PKH5; A0A7K5QIU3; A0A7K5S142; A0A7K5SPK9; A0A7K5UC76; A0A7K5W8H5; A0A7K5XD37; A0A7K5Y7M0; A0A7K5ZW11; A0A7K6B2F8; A0A7K6BQV7; A0A7K6DCL1; A0A7K6EXZ1; A0A7K6FLR8; A0A7K6GNU4; A0A7K6HR31; A0A7K6J4T9; A0A7K6K4L6; A0A7K6LWQ9; A0A7K6M0L3; A0A7K6P948; A0A7K6RCV4; A0A7K6TEI2; A0A7K6VY88; A0A7K6XPH0; A0A7K6Z9M8; A0A7K6ZR93; A0A7K7AYM3; A0A7K7C659; A0A7K7DZL3; A0A7K7EWS4; A0A7K7G760; A0A7K7IH73; A0A7K7KDI8; A0A7K7KKJ6; A0A7K7MNF7; A0A7K7NEW8; A0A7K7PM04; A0A7K7QH90; A0A7K7RDG5; A0A7K7TAJ1; A0A7K7U609; A0A7K7XKX1; A0A7K8AQB9; A0A7K8BQL5; A0A7K8CRX7; A0A7K8EFR7; A0A7K8FRF9; A0A7K8GQ26; A0A7K8HWN9; A0A7K8ISA9; A0A7K8JPZ4; A0A7K8KS65; A0A7K8M0C5; A0A7K8N2Y9; A0A7K8PDY4; A0A7K8QME0; A0A7K8S6K4; A0A7K8T8U7; A0A7K8U5E0; A0A7K8VJC8; A0A7K8WMV3; A0A7K8Y2D4; A0A7K8YWW6; A0A7K8ZV32; A0A7K9AJ30; A0A7K9BS34; A0A7K9D6V1; A0A7K9EI05; A0A7K9FLR9; A0A7K9I701; A0A7K9IMC9; A0A7K9KC93; A0A7K9MVB8; A0A7K9NB46; A0A7K9PEG9; A0A7K9RST5; A0A7K9TK91; A0A7K9V843; A0A7K9W2K2; A0A7K9WX62; A0A7L0AFU5; A0A7L0BDS5; A0A7L0CIB3; A0A7L0EPL5; A0A7L0FCD1; A0A7L0G7Q5; A0A7L0HND8; A0A7L0II88; A0A7L0KT22; A0A7L0LSN2; A0A7L0NLS0; A0A7L0P7X4; A0A7L0RUG0; A0A7L0SJQ9; A0A7L0UGT7; A0A7L0XTP2; A0A7L0ZS39; A0A7L1B939; A0A7L1BT59; A0A7L1DMI6; A0A7L1DWR3; A0A7L1F253; A0A7L1GIR7; A0A7L1HPS8; A0A7L1IC62; A0A7L1K5Y1; A0A7L1L5V3; A0A7L1M7T5; A0A7L1NKU4; A0A7L1R8Z0; A0A7L1T000; A0A7L1U068; A0A7L1XCH6; A0A7L1YLD6; A0A7L2B7P4; A0A7L2BR48; A0A7L2CKL5; A0A7L2ESG9; A0A7L2FHP9; A0A7L2FY76; A0A7L2HHD4; A0A7L2IA74; A0A7L2JHG8; A0A7L2KMU3; A0A7L2LNS8; A0A7L2P8R5; A0A7L2QEC4; A0A7L2RU84; A0A7L2TB66; A0A7L2UV13; A0A7L2XQZ8; A0A7L2Z1X6; A0A7L2ZLP6; A0A7L3CN30; A0A7L3D9C1; A0A7L3GMY1; A0A7L3GYG9; A0A7L3ID24; A0A7L3IXN1; A0A7L3KUM5; A0A7L3LJJ7; A0A7L3M3X9; A0A7L3PPQ0; A0A7L3QHZ1; A0A7L3RH67; A0A7L3SGI7; A0A7L3U4P6; A0A7L3VNT2; A0A7L3WD55; A0A7L3Y1G6; A0A7L3YVD7; A0A7L3ZS54; A0A7L4AN29; A0A7L4CQM9; A0A7L4D5C7; A0A7L4DZI8; A0A7L4G527; A0A7L4GV55; A0A7L4IYY1; A0A7L4JN17; A0A7L4KJ61; A0A7L4MPA2; A0A7L4NEP2; A0A835NXC8; A0A850U7W3; A0A850V3D3; A0A850XEM6; A0A850Y843; A0A850ZDL2; A0A851BEY3; A0A851CN67; A0A851DTB7; A0A851EK28; A0A851FDE8; A0A851J837; A0A851KA41; A0A851LW39; A0A851NRY4; A0A851QJ25; A0A851RNA5; A0A851U848; A0A851VUC7; A0A851WKT2; A0A851XT74; A0A851YL06; A0A851ZBL2; A0A852BHA9; A0A852CRR6; A0A852D425; A0A852E1V9; A0A852F792; A0A852GJG7; A0A852IBF3; A0A852JDC5; A0A852JR42; A0A852KVX0; A0A852LXY4; A0A852NS61; A0A8B6ZNK4; A0A8B7GBR5; A0A8B7Q300; A0A8B8TZT0; A0A8B9CLG9; A0A8B9DEA1; A0A8B9GFW6; A0A8B9NJE6; A0A8B9QKT1; A0A8B9SHJ3; A0A8B9Y7Y7; A0A8C0DED2; A0A8C0H293; A0A8C0LYE1; A0A8C0N2I3; A0A8C2UWB6; A0A8C3CSU8; A0A8C3FFU4; A0A8C3L8M1; A0A8C3PH13; A0A8C3QCR3; A0A8C3SQW8; A0A8C3TNI9; A0A8C3WY11; A0A8C4PR70; A0A8C4U1I2; A0A8C4YAW6; A0A8C5IXG8; A0A8C5P2E0; A0A8C5RKR8; A0A8C5UFH7; A0A8C6FKL7; A0A8C6GS76; A0A8C6NGV1; A0A8C6QM24; A0A8C7BWL1; A0A8C8BUD5; A0A8C8S3P8; A0A8C8Y8T7; A0A8C9C427; A0A8C9LFS5; A0A8C9MJH4; A0A8D0E9T9; A0A8D0FGF9; A0A8D2B3M6; A0A8D2F0S7; A0A8D2GFE7; A0A8D2LUT0; A0A8J4MUQ6; A0A8J4N2X1; A0A8J4NK31; A0A8J4NVY9; A0A8J4PAG4; A0A8K0BNH4; A0A8K1LSE9; A0A8M1FCK6; A0A8P0NAG9; A0A8S9F5P5; A0A8U0V7M2; A0A9B0WSP0; A0A9F2KUS3; A0A9Q0Y593; A0A9V1E5M8; A0AA35K559; A0AA40L2Y5; A0AA41N2J4; acs:100566789; aful:116488210; aju:106984378; bbis:104987264; brhi:104488844; bta:281592; cang:105505494; cbrc:103624093; ccan:109689807; cfr:102507445; cjc:100395910; cmy:102943964; cpic:101942538; cpoc:100716933; cuca:104060336; cvf:104291844; dle:111163953; dpub:104300855; ecb:100065454; egz:104131026; elk:111160482; F7E1F2; F7FWZ0; F7HNV4; G1K932; G1LEZ5; G1NHJ8; G3SXX7; G3WM41; gga:421534; H0UXP6; H0XEG0; H0ZIF5; H2Q1A9; hai:109372851; hsa:58; I3N266; J3SBR4; K7F4I9; lav:100661558; M3XC93; M7AKZ6; maua:101822895; mcc:100426612; mcf:102121165; mgp:100542212; mmu:11459; mmur:105871143; mni:105499142; ngi:103744113; nss:113413315; nsu:110582311; oas:101107662; oga:100955023; oro:101371004; P02568; P68133; P68134; P68135; P68136; P68137; P68138; P68139; P99020; panu:101018268; pbi:103051164; pcad:102976743; pcoq:105823179; pcw:110217891; pdic:114512380; pgut:117672003; pon:100172818; pps:100987270; pss:102446120; ptr:100609865; pvt:110075363; Q3ZCG3; Q5R9Q5; Q5T8M9; rbb:108537854; rno:29437; scan:103818506; shr:100926492; ssc:100154254; T1E7F6; tmu:101345310; tsr:106543751; U3EUL6; U3I8T6; umr:103661861; V8NV61; W5NYJ1; zca:113923883" "FAS pathway and stress induction of HSP regulation; Hypothetical network for drug addiction; Myometrial relaxation and contraction pathways; Myometrial relaxation and contraction pathways; Fas ligand pathway and stress induction of heat shock proteins; Striated muscle contraction; Myometrial relaxation and contraction pathways; Physico-chemical features and toxicity-associated pathways; Striated muscle contraction pathway; Myometrial relaxation and contraction pathways; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; IL-18 signaling pathway; Burn wound healing; Pleural mesothelioma; Comprehensive IL-17A signaling; Striated muscle contraction" "Striated Muscle Contraction; Striated Muscle Contraction; Striated Muscle Contraction; Striated Muscle Contraction; Striated Muscle Contraction; Striated Muscle Contraction" "22" "0" "0.955" "1.052" "1.018" "1.069" "1.038" "1.017" "1.089" "1.094" "1.029" "942.6" "899.9" "991.2" "960.0" "1007.6" "978.8" "958.6" "1026.2" "1030.9" "969.6" "" "" "" "" "" "" "" "" "" "" "883.2" "744.6" "920.2" "742.1" "858.9" "935.1" "875.9" "911.2" "1030.9" "933.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7944368975479606522" "False" "High" "IsMasterProtein" "O94979" "Protein transport protein Sec31A OS=Homo sapiens OX=9606 GN=SEC31A PE=1 SV=3" "0.000" "False" "65.519" "20" "21" "32" "21" "1220" "132.9" "6.89" "112.13" "21" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf12931" "22872" "ENSG00000138674" "SEC31A" "B4DIW6; B7ZKZ7; B7ZL00; H7C2W3; hsa:22872; O94979; Q17RR5; Q5H9P6; Q5XG74; Q659G7; Q6ZU90; Q7LCX9; Q86TJ0; Q8IZH4; Q9P048; Q9P0A6; Q9UM05; Q9UM06" "Sterol regulatory element-binding proteins (SREBP) signaling" "Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "6" "0" "0.992" "1.016" "1.027" "1.033" "1.027" "0.979" "0.969" "0.976" "1.016" "3214.7" "3188.6" "3267.4" "3302.4" "3319.4" "3301.0" "3145.9" "3116.3" "3137.8" "3266.1" "" "" "" "" "" "" "" "" "" "" "3012.2" "2638.6" "3033.4" "2552.9" "2829.4" "3153.8" "2874.5" "2767.0" "3137.8" "3144.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5250221047475229599" "False" "High" "IsMasterProtein" "Q7LBC6" "Lysine-specific demethylase 3B OS=Homo sapiens OX=9606 GN=KDM3B PE=1 SV=2" "0.000" "False" "65.450" "14" "23" "31" "21" "1761" "191.5" "7.18" "82.40" "23" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "51780" "ENSG00000120733" "KDM3B" "A6H8X7; hsa:51780; Q7LBC6; Q9BVH6; Q9BW93; Q9BZ52; Q9NYF4; Q9UPS0" "Thermogenesis" "HDMs demethylate histones" "2" "0" "1.018" "0.986" "0.998" "1.016" "1.015" "0.995" "0.998" "0.982" "1.049" "2135.2" "2172.9" "2105.9" "2130.6" "2169.3" "2168.1" "2124.4" "2130.2" "2097.5" "2240.4" "" "" "" "" "" "" "" "" "" "" "2000.7" "1798.1" "1955.0" "1647.1" "1849.1" "2071.4" "1941.1" "1891.4" "2097.5" "2157.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8198738028437086806" "False" "High" "IsMasterProtein" "Q7Z2W4" "Zinc finger CCCH-type antiviral protein 1 OS=Homo sapiens OX=9606 GN=ZC3HAV1 PE=1 SV=3" "0.000" "False" "65.373" "27" "22" "36" "22" "902" "101.4" "8.40" "95.53" "22" "stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00644, Pf02825, Pf18606, Pf18633" "56829" "ENSG00000105939" "ZC3HAV1" "A4D1R2; A4D1S4; hsa:56829; Q7Z2W4; Q8IW57; Q8TAJ3; Q96N79; Q9H8R9; Q9P0Y7" "" "Signaling by BRAF and RAF1 fusions" "1" "0" "1.021" "1.041" "1.031" "1.046" "1.033" "1.028" "0.994" "0.997" "1.047" "2499.9" "2552.4" "2601.5" "2578.3" "2613.9" "2583.4" "2571.0" "2484.2" "2493.6" "2617.7" "" "" "" "" "" "" "" "" "" "" "2342.4" "2112.1" "2415.2" "1993.1" "2228.0" "2468.2" "2349.3" "2205.7" "2493.6" "2520.5" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5207555211981118816" "False" "High" "IsMasterProtein" "Q08J23" "RNA cytosine C(5)-methyltransferase NSUN2 OS=Homo sapiens OX=9606 GN=NSUN2 PE=1 SV=2" "0.000" "False" "65.220" "32" "20" "33" "20" "767" "86.4" "6.77" "110.96" "20" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01189" "54888" "ENSG00000037474" "NSUN2" "A8K529; B2RNR4; B3KP09; B4DQW2; G3V1R4; hsa:54888; Q08J23; Q9BVN4; Q9H858; Q9NXD9" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.021" "0.996" "0.963" "0.977" "0.974" "0.914" "0.973" "1.073" "1.025" "2584.2" "2637.7" "2573.4" "2489.0" "2525.9" "2517.1" "2361.3" "2515.5" "2772.6" "2647.8" "" "" "" "" "" "" "" "" "" "" "2421.4" "2182.7" "2389.1" "1924.1" "2153.0" "2404.9" "2157.6" "2233.5" "2772.6" "2549.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7238306351176714360" "False" "High" "IsMasterProtein" "Q14974" "Importin subunit beta-1 OS=Homo sapiens OX=9606 GN=KPNB1 PE=1 SV=2" "0.000" "False" "65.191" "22" "16" "36" "16" "876" "97.1" "4.78" "109.89" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00514, Pf03810" "3837" "ENSG00000108424" "KPNB1" "B7ZAV6; D3DTT3; hsa:3837; Q14637; Q14974; Q53XN2; Q96J27" "Sterol regulatory element-binding proteins (SREBP) signaling; 22q11.2 copy number variation syndrome" "Neutrophil degranulation; Apoptosis induced DNA fragmentation; Interferon alpha/beta signaling; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Nuclear import of Rev protein; Regulation of cholesterol biosynthesis by SREBP (SREBF); SARS-CoV-1 activates/modulates innate immune responses; Assembly of the ORC complex at the origin of replication; Initiation of Nuclear Envelope (NE) Reformation; Postmitotic nuclear pore complex (NPC) reformation; Inhibition of nitric oxide production" "15" "0" "1.004" "0.969" "1.128" "1.037" "0.974" "1.102" "1.029" "0.953" "1.014" "1991.7" "1999.7" "1929.2" "2246.0" "2065.0" "1939.2" "2194.5" "2049.7" "1898.0" "2020.2" "" "" "" "" "" "" "" "" "" "" "1866.2" "1654.7" "1791.0" "1736.3" "1760.2" "1852.7" "2005.2" "1819.9" "1898.0" "1945.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7972522835468462088" "False" "High" "IsMasterProtein" "O43432" "Eukaryotic translation initiation factor 4 gamma 3 OS=Homo sapiens OX=9606 GN=EIF4G3 PE=1 SV=2" "0.000" "False" "65.018" "13" "23" "25" "16" "1585" "176.5" "5.38" "72.40" "23" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf02020, Pf02847, Pf02854" "8672" "ENSG00000075151" "EIF4G3" "B9EGQ7; hsa:8672; O43432; Q15597; Q504Z1; Q5SWC3; Q8NEN1" "Translation factors; Translation inhibitors in chronically activated PDGFRA cells" "ISG15 antiviral mechanism" "3" "0" "0.991" "0.991" "0.998" "0.985" "1.022" "0.963" "0.986" "0.970" "1.010" "2576.0" "2553.2" "2553.2" "2572.1" "2538.4" "2633.7" "2481.5" "2540.6" "2498.9" "2603.0" "" "" "" "" "" "" "" "" "" "" "2413.7" "2112.7" "2370.4" "1988.3" "2163.6" "2516.2" "2267.4" "2255.8" "2498.9" "2506.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-160533791377362281" "False" "High" "IsMasterProtein" "P07195" "L-lactate dehydrogenase B chain OS=Homo sapiens OX=9606 GN=LDHB PE=1 SV=2" "0.000" "False" "64.962" "44" "15" "70" "13" "334" "36.6" "6.05" "203.76" "15" "other metabolic processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "3945" "ENSG00000111716" "LDHB" "hsa:3945; P07195" "Clear cell renal cell carcinoma pathways; CCL18 signaling pathway; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Pyruvate metabolism" "5" "0" "0.869" "0.944" "0.896" "0.897" "0.935" "0.897" "0.913" "0.927" "0.898" "6070.9" "5274.0" "5729.8" "5440.0" "5445.8" "5673.4" "5444.3" "5541.7" "5628.1" "5449.4" "" "" "" "" "" "" "" "" "" "" "5688.4" "4364.2" "5319.4" "4205.4" "4641.9" "5420.4" "4974.7" "4920.4" "5628.1" "5247.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4305624722430213023" "False" "High" "IsMasterProtein" "Q9H4A3" "Serine/threonine-protein kinase WNK1 OS=Homo sapiens OX=9606 GN=WNK1 PE=1 SV=2" "0.000" "False" "64.843" "10" "24" "35" "24" "2382" "250.6" "6.34" "96.82" "24" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf12202" "65125" "ENSG00000060237" "WNK1" "A1L4B0; C5HTZ5; C5HTZ6; C5HTZ7; H6WZW3; hsa:65125; O15052; P54963; Q4VBX9; Q6IFS5; Q86WL5; Q8N673; Q96CZ6; Q9H4A3; Q9P1S9" "Ciliary landscape" "Stimuli-sensing channels" "2" "0" "1.066" "0.996" "1.071" "1.005" "0.963" "0.959" "0.989" "0.990" "1.007" "3277.4" "3494.5" "3263.8" "3508.8" "3294.1" "3156.7" "3141.9" "3241.0" "3244.9" "3301.2" "" "" "" "" "" "" "" "" "" "" "3070.9" "2891.6" "3030.1" "2712.4" "2807.8" "3015.9" "2870.9" "2877.6" "3244.9" "3178.6" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1882334441137329574" "False" "High" "IsMasterProtein" "Q9BUJ2" "Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Homo sapiens OX=9606 GN=HNRNPUL1 PE=1 SV=2" "0.000" "False" "64.813" "21" "18" "32" "18" "856" "95.7" "6.92" "103.34" "18" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00622, Pf02037, Pf13671" "11100" "ENSG00000105323" "HNRNPUL1" "B3KMW7; hsa:11100; O76022; Q6ZSZ0; Q7L8P4; Q8N6Z4; Q96G37; Q9BUJ2; Q9HAL3; Q9UG75" "" "" "0" "0" "0.988" "1.015" "1.002" "1.072" "1.204" "1.036" "1.109" "1.074" "1.069" "3957.9" "3909.7" "4019.2" "3965.9" "4242.0" "4764.3" "4101.5" "4389.9" "4251.6" "4232.3" "" "" "" "" "" "" "" "" "" "" "3708.6" "3235.3" "3731.3" "3065.8" "3615.8" "4551.9" "3747.7" "3897.8" "4251.6" "4075.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1978266596079071295" "False" "High" "IsMasterProtein" "Q01518" "Adenylyl cyclase-associated protein 1 OS=Homo sapiens OX=9606 GN=CAP1 PE=1 SV=5" "0.000" "False" "64.809" "34" "16" "44" "9" "475" "51.9" "8.06" "121.67" "16" "cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf01213, Pf08603" "10487" "ENSG00000131236" "CAP1" "hsa:10487; Q01518; Q53HR7; Q5T0S1; Q5T0S2; Q6I9U6" "Angiopoietin-like protein 8 regulatory pathway; Insulin signaling; Complement system in neuronal development and plasticity; Opioid receptor pathways" "Neutrophil degranulation; Platelet degranulation ; Role of ABL in ROBO-SLIT signaling" "7" "7" "0.974" "1.008" "0.917" "0.950" "0.959" "0.923" "0.946" "0.981" "0.914" "3206.2" "3123.7" "3232.5" "2941.3" "3044.9" "3075.7" "2960.1" "3033.9" "3145.8" "2931.6" "" "" "" "" "" "" "" "" "" "" "3004.2" "2584.8" "3000.9" "2273.8" "2595.4" "2938.5" "2704.8" "2693.8" "3145.8" "2822.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6048249212605468111" "False" "High" "IsMasterProtein" "P30876" "DNA-directed RNA polymerase II subunit RPB2 OS=Homo sapiens OX=9606 GN=POLR2B PE=1 SV=1" "0.000" "False" "64.754" "20" "22" "25" "22" "1174" "133.8" "6.87" "80.83" "22" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04566, Pf04567" "5431" "ENSG00000047315" "POLR2B" "A8K1A8; hsa:5431; P30876; Q8IZ61" "Pyrimidine metabolism; Eukaryotic transcription initiation" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "43" "0" "0.980" "0.993" "1.011" "0.965" "0.968" "0.947" "0.947" "0.946" "0.950" "4302.3" "4218.2" "4274.2" "4350.2" "4153.5" "4164.7" "4075.0" "4075.3" "4070.9" "4087.3" "" "" "" "" "" "" "" "" "" "" "4031.2" "3490.5" "3968.0" "3362.9" "3540.4" "3979.0" "3723.5" "3618.5" "4070.9" "3935.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1618262664170988145" "False" "High" "IsMasterProtein" "P61978" "Heterogeneous nuclear ribonucleoprotein K OS=Homo sapiens OX=9606 GN=HNRNPK PE=1 SV=1" "0.000" "False" "64.706" "40" "17" "79" "17" "463" "50.9" "5.54" "233.05" "17" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf08067" "3190" "ENSG00000165119" "HNRNPK" "hsa:3190; P61978; Q07244; Q15671; Q59F98; Q5T6W4; Q60577; Q6IBN1; Q922Y7; Q96J62" "mRNA processing; lncRNA in canonical Wnt signaling and colorectal cancer" "mRNA Splicing - Major Pathway; HCMV Late Events; SUMOylation of RNA binding proteins; Processing of Capped Intron-Containing Pre-mRNA" "6" "0" "0.978" "0.976" "1.012" "0.968" "0.971" "0.986" "0.960" "1.016" "0.964" "8876.0" "8676.7" "8658.8" "8986.0" "8594.5" "8618.7" "8754.4" "8521.0" "9014.8" "8553.6" "" "" "" "" "" "" "" "" "" "" "8316.8" "7179.9" "8038.6" "6946.6" "7325.7" "8234.4" "7999.2" "7565.8" "9014.8" "8235.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7902692244369353681" "False" "High" "IsMasterProtein" "Q9Y6G9" "Cytoplasmic dynein 1 light intermediate chain 1 OS=Homo sapiens OX=9606 GN=DYNC1LI1 PE=1 SV=3" "0.000" "False" "64.682" "39" "18" "31" "18" "523" "56.5" "6.42" "105.70" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05783" "51143" "ENSG00000144635" "DYNC1LI1" "A2RRG7; hsa:51143; Q53HC8; Q53HK7; Q9Y6G9" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption" "MHC class II antigen presentation; Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "16" "0" "0.937" "1.007" "0.941" "0.983" "0.986" "0.879" "0.952" "0.952" "0.974" "3329.1" "3120.6" "3352.1" "3132.9" "3271.7" "3282.4" "2926.3" "3170.7" "3168.0" "3243.4" "" "" "" "" "" "" "" "" "" "" "3119.4" "2582.3" "3112.0" "2421.9" "2788.7" "3136.1" "2673.9" "2815.3" "3168.0" "3123.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1042042739323188079" "False" "High" "IsMasterProtein" "Q9UQ35" "Serine/arginine repetitive matrix protein 2 OS=Homo sapiens OX=9606 GN=SRRM2 PE=1 SV=2" "0.000" "False" "64.679" "10" "21" "23" "21" "2752" "299.4" "12.06" "69.38" "21" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08312" "23524" "ENSG00000167978" "SRRM2" "A6NKB9; D3DU97; hsa:23524; O15038; O94803; Q6NSL3; Q6PIM3; Q6PK40; Q8IW17; Q96GY7; Q9P0G1; Q9UHA8; Q9UQ35; Q9UQ36; Q9UQ37; Q9UQ38; Q9UQ40" "" "mRNA Splicing - Major Pathway" "1" "0" "1.014" "1.058" "1.098" "1.108" "1.103" "1.392" "1.373" "1.343" "1.208" "1934.5" "1961.0" "2046.4" "2124.9" "2143.8" "2134.5" "2692.3" "2655.5" "2597.9" "2336.2" "" "" "" "" "" "" "" "" "" "" "1812.6" "1622.7" "1899.8" "1642.7" "1827.3" "2039.3" "2460.1" "2357.9" "2597.9" "2249.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3348063048302493190" "False" "High" "IsMasterProtein" "P50851" "Lipopolysaccharide-responsive and beige-like anchor protein OS=Homo sapiens OX=9606 GN=LRBA PE=1 SV=4" "0.000" "False" "64.615" "8" "23" "31" "23" "2863" "318.9" "5.60" "93.54" "23" "cell organization and biogenesis;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf02138, Pf06469, Pf13385, Pf14844, Pf15787, Pf20425, Pf20426" "987" "ENSG00000198589" "LRBA" "hsa:987; P50851; Q4W5J4; Q4W5L6; Q8NFQ0; Q9H2U3; Q9H2U4" "" "" "0" "0" "0.968" "0.994" "1.007" "1.018" "0.993" "0.969" "0.972" "0.962" "0.998" "3035.2" "2936.7" "3015.9" "3056.4" "3089.0" "3012.6" "2941.4" "2951.1" "2921.1" "3027.8" "" "" "" "" "" "" "" "" "" "" "2844.0" "2430.1" "2799.8" "2362.7" "2632.9" "2878.2" "2687.7" "2620.3" "2921.1" "2915.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7785579833791404998" "False" "High" "IsMasterProtein" "P17980" "26S proteasome regulatory subunit 6A OS=Homo sapiens OX=9606 GN=PSMC3 PE=1 SV=3" "0.000" "False" "64.510" "41" "16" "35" "16" "439" "49.2" "5.24" "109.01" "16" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5702" "ENSG00000165916" "PSMC3" "B2R8V1; hsa:5702; P17980; Q3B757; Q3B865; Q53HU5; Q6GPG8; Q6IBS1; Q96HD3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; MAPK6/MAPK4 signaling; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "1.000" "1.028" "0.983" "1.006" "1.010" "0.935" "0.989" "1.010" "0.993" "4948.2" "4946.4" "5085.2" "4862.7" "4978.7" "4996.0" "4625.9" "4894.8" "4998.4" "4915.5" "" "" "" "" "" "" "" "" "" "" "4636.5" "4093.1" "4721.0" "3759.1" "4243.7" "4773.2" "4226.8" "4346.1" "4998.4" "4732.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1657262686538344528" "False" "High" "IsMasterProtein" "O75717" "WD repeat and HMG-box DNA-binding protein 1 OS=Homo sapiens OX=9606 GN=WDHD1 PE=1 SV=1" "0.000" "False" "64.392" "19" "20" "25" "20" "1129" "125.9" "5.62" "83.60" "20" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12341, Pf12894, Pf20946" "11169" "ENSG00000198554" "WDHD1" "C9JW18; F6W0U7; hsa:11169; O75717" "Mesodermal commitment pathway" "" "1" "0" "1.006" "0.991" "0.981" "0.971" "0.968" "0.983" "0.956" "0.971" "0.983" "2824.1" "2840.5" "2799.6" "2770.3" "2743.0" "2732.7" "2776.4" "2700.4" "2743.2" "2775.6" "" "" "" "" "" "" "" "" "" "" "2646.2" "2350.5" "2599.1" "2141.6" "2338.1" "2610.8" "2536.9" "2397.7" "2743.2" "2672.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-410325427073227732" "False" "High" "IsMasterProtein" "Cont_P68103" "Elongation factor 1-alpha 1 OS=Bos taurus OX=9913 GN=EEF1A1 PE=1 SV=1" "0.000" "True" "64.337" "31" "15" "83" "15" "462" "50.1" "9.01" "254.39" "15" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "100009189; 100137407; 100173928; 100415334; 100455760; 100583632; 100720380; 100860780; 100894850; 100978974; 101016039; 101102857; 101114018; 101120236; 101143481; 101427577; 101925273; 102283704; 102540473; 102729396; 102952660; 102986013; 103243896; 104657006; 104668174; 104669279; 104675330; 105064770; 105589208; 108529199; 108538073; 109248229; 109261840; 109563706; 1915; 282220; 403506; 493922; 494136; 574059; 716010" "ENSBGRG00000009070; ENSBIXG00000015018; ENSBIXG00005015547; ENSBMUG00000019814; ENSBTAG00000014534; ENSCABG00000013336; ENSCAFG00000002656; ENSCAFG00000054475; ENSCAFG00000056088; ENSCAFG00000057183; ENSCAFG00030004385; ENSCAFG00030013393; ENSCAFG00030013497; ENSCAFG00030026219; ENSCAFG00040018088; ENSCAFG00845012150; ENSCATG00000039727; ENSCCAG00000033087; ENSCHIG00000010087; ENSCJAG00000083200; ENSCPOG00000004067; ENSCSAG00000014041; ENSCWAG00000008166; ENSEASG00005004328; ENSEASG00005023174; ENSFCAG00000030977; ENSG00000156508; ENSGGOG00000025675; ENSLCNG00005010676; ENSMMUG00000004852; ENSNLEG00000035164; ENSOARG00000006149; ENSOARG00000007762; ENSOARG00000011616; ENSOCUG00000008481; ENSPANG00000006932; ENSPCTG00005022294; ENSPLOG00000016117; ENSPPAG00000038736; ENSPPYG00000016777; ENSPTEG00000025546; ENSPTIG00000007871; ENSPTRG00000018347; ENSRBIG00000028957; ENSRROG00000044652; ENSSSCG00005007871; ENSSSCG00015021824; ENSSSCG00035049336; ENSSSCG00060027448; ENSSSCG00065043427; ENSSSCG00070013256; ENSTGEG00000013204" "EEF1A; Eef1a1; EEF1A1; LOC102523342; LOC102540473; LOC105064770; LOC105879067; LOC111096123; LOC111152497; LOC112630422; LOC118356941; RABEFLA2" "A0A096NSJ4; A0A0D9RNJ1; A0A2I3HHP9; A0A2J8PVY3; A0A2J8RYS8; A0A2K5N7Z5; A0A2K5RPQ1; A0A2K6KG30; A0A2K6RQ54; A0A2R9BYN3; A0A2U3XB66; A0A2Y9F799; A0A2Y9HH84; A0A2Y9K0L0; A0A452E2H7; A0A485PKI5; A0A4W2G2H2; A0A4X1U102; A0A5N4BZH2; A0A663DJ63; A0A667H9L1; A0A6I9I937; A0A6J0YU90; A0A6J1ZA85; A0A6J3HMT0; A0A6P5CAS0; A0A6P6HZ37; A0A6P7EC07; A0A6P7EG13; A0A6P9FBB6; A0A811YU57; A0A8B7HCC5; A0A8B8RGI1; A0A8B9X6G1; A0A8C0H2M0; A0A8C0NJT4; A0A8C3W2U9; A0A8C4L5X9; A0A8C8XSK7; A0A8C9HVZ6; A0A8C9JCC1; A0A8D0I6I6; A0A8D2F6F8; A0A8D8FTM6; A0A8H2XW05; A0A8I3VX86; A0A8M1H472; A0A8U0UW05; A0A9L0JZA8; A0A9V1E3R7; A0A9W3GP67; A5PK01; A9X189; aju:106980206; B1MTF5; B7NZC3; biu:109563706; bom:102283704; bta:282220; C3PT41; caty:105589208; cfa:403506; cfr:102523342; chx:100860780; cjc:100415334; cjc:100894850; cpoc:100720380; csab:103243896; dnm:101427577; elk:111152497; F1RQG6; F2Z4P4; F6VFC8; F7AW94; fca:493922; G2HFA2; G3S518; ggo:101143481; H0V2B3; hsa:1915; L8I7U3; lww:102729396; mcc:716010; mcf:101925273; mmur:105879067; mpuf:101672541; nle:100583632; nsu:110583033; oas:101102857; oas:101114018; oas:101120236; ocu:100009189; P04719; P04720; P68103; P68104; P68105; panu:100137407; panu:101016039; pcad:102986013; pcoo:112862036; pon:100173928; pon:100455760; pps:100978974; ptg:102952660; ptr:494136; Q0PY11; Q2KJJ3; Q4R5K0; Q5NVF3; Q5R1X2; Q5R4R8; Q66RN5; Q6IPS9; Q6IQ15; rbb:108529199; rbb:108538073; rro:104657006; rro:104668174; rro:104669279; rro:104675330; ssc:574059; umr:103657393; vpc:102540473; W5PD15; zca:118356820; zca:118356941" "Translation factors; EGFR1 signaling pathway; Fragile X syndrome; 2q37 copy number variation syndrome; EGFR1 signaling pathway" "Neutrophil degranulation; Protein methylation; HSF1 activation; Eukaryotic Translation Elongation; Peptide chain elongation; Neutrophil degranulation; Neutrophil degranulation; Protein methylation; Eukaryotic Translation Elongation; HSF1 activation; Chaperone Mediated Autophagy; Protein methylation; HSF1 activation; SARS-CoV-1 modulates host translation machinery" "20" "0" "1.020" "1.037" "1.013" "0.985" "1.026" "0.907" "0.987" "0.993" "0.995" "10326.7" "10529.5" "10705.3" "10457.3" "10167.1" "10595.2" "9367.3" "10191.8" "10252.2" "10275.6" "" "" "" "" "" "" "" "" "" "" "9676.1" "8713.0" "9938.5" "8084.0" "8666.2" "10122.7" "8559.2" "9049.3" "10252.2" "9894.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1710957495581241362" "False" "High" "IsMasterProtein" "Q15276" "Rab GTPase-binding effector protein 1 OS=Homo sapiens OX=9606 GN=RABEP1 PE=1 SV=2" "0.000" "False" "64.326" "25" "22" "28" "22" "862" "99.2" "5.01" "92.61" "22" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf03528, Pf09311" "9135" "ENSG00000029725" "RABEP1" "B2RAG7; hsa:9135; O95369; Q15276; Q8IVX3" "GDNF signaling" "TBC/RABGAPs" "2" "0" "0.978" "0.965" "0.979" "0.999" "1.022" "1.024" "0.978" "0.958" "1.008" "3319.9" "3245.8" "3202.3" "3248.9" "3316.1" "3392.5" "3400.8" "3247.3" "3181.1" "3346.4" "" "" "" "" "" "" "" "" "" "" "3110.7" "2685.9" "2973.0" "2511.5" "2826.5" "3241.2" "3107.4" "2883.2" "3181.1" "3222.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3779865839115366179" "False" "High" "IsMasterProtein" "P00367" "Glutamate dehydrogenase 1, mitochondrial OS=Homo sapiens OX=9606 GN=GLUD1 PE=1 SV=2" "0.000" "False" "64.296" "35" "18" "30" "18" "558" "61.4" "7.80" "97.37" "18" "other metabolic processes;other biological processes" "mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00208, Pf02812" "2746" "ENSG00000148672" "GLUD1" "B3KV55; B4DGN5; hsa:2746; P00367; Q5TBU3" "VEGFA-VEGFR2 signaling; Amino acid metabolism; Metabolic reprogramming in colon cancer; 22q11.2 copy number variation syndrome; Amino acid metabolism pathway excerpt: histidine catabolism extension; 10q22q23 copy number variation" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation; Glutamate and glutamine metabolism" "9" "0" "0.968" "1.027" "0.980" "1.015" "0.982" "1.015" "0.970" "0.999" "0.984" "4251.3" "4115.8" "4366.8" "4167.3" "4316.9" "4173.6" "4316.9" "4125.0" "4245.0" "4185.0" "" "" "" "" "" "" "" "" "" "" "3983.5" "3405.8" "4054.1" "3221.5" "3679.6" "3987.4" "3944.5" "3662.5" "4245.0" "4029.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2158743068394578481" "False" "High" "IsMasterProtein" "P29401" "Transketolase OS=Homo sapiens OX=9606 GN=TKT PE=1 SV=3" "0.000" "False" "64.140" "29" "17" "50" "17" "623" "67.8" "7.66" "166.77" "17" "other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf00456, Pf02779, Pf02780" "7086" "ENSG00000163931" "TKT" "A8K089; B4DE31; E7EPA7; hsa:7086; P29401; Q8TBA3; Q96HH3" "Pentose phosphate metabolism; VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways" "NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate" "7" "0" "1.067" "0.979" "1.007" "0.953" "1.037" "0.928" "1.010" "1.028" "0.963" "4017.7" "4286.0" "3933.8" "4045.7" "3829.1" "4166.7" "3730.2" "4057.5" "4128.3" "3868.4" "" "" "" "" "" "" "" "" "" "" "3764.6" "3546.6" "3652.1" "3127.5" "3263.9" "3980.9" "3408.4" "3602.6" "4128.3" "3724.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4630001761870027344" "False" "High" "IsMasterProtein" "P34897" "Serine hydroxymethyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=SHMT2 PE=1 SV=3" "0.000" "False" "64.122" "39" "19" "35" "18" "504" "56.0" "8.53" "110.08" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00464" "6472" "ENSG00000182199" "SHMT2" "B7Z9F1; E7EQ19; E7EU43; hsa:6472; O00740; P34897; Q8N1A5" "Glycine metabolism; Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Metabolic Epileptic Disorders" "RHOG GTPase cycle; Mitochondrial protein degradation; Metabolism of folate and pterines" "13" "1" "1.084" "1.026" "0.971" "1.007" "1.033" "0.931" "1.040" "1.084" "0.990" "3303.2" "3581.2" "3388.6" "3208.1" "3326.7" "3412.6" "3074.9" "3436.8" "3579.7" "3269.6" "" "" "" "" "" "" "" "" "" "" "3095.1" "2963.4" "3145.8" "2480.0" "2835.6" "3260.4" "2809.7" "3051.5" "3579.7" "3148.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1477701677307109055" "False" "High" "IsMasterProtein" "P27694" "Replication protein A 70 kDa DNA-binding subunit OS=Homo sapiens OX=9606 GN=RPA1 PE=1 SV=2" "0.000" "False" "64.111" "36" "20" "26" "20" "616" "68.1" "7.21" "83.06" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01336, Pf04057, Pf08646, Pf16900" "6117" "ENSG00000132383" "RPA1" "A8K0Y9; hsa:6117; P27694; Q59ES9" "Homologous recombination; Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "SUMOylation of DNA damage response and repair proteins; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Meiotic recombination; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "38" "0" "0.956" "1.023" "0.963" "0.948" "0.968" "0.976" "1.020" "1.019" "0.994" "3738.1" "3571.8" "3822.6" "3598.1" "3545.5" "3619.7" "3649.5" "3814.0" "3810.3" "3714.9" "" "" "" "" "" "" "" "" "" "" "3502.6" "2955.6" "3548.8" "2781.5" "3022.1" "3458.3" "3334.7" "3386.5" "3810.3" "3576.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-242309002880936469" "False" "High" "IsMasterProtein" "Q8NI27" "THO complex subunit 2 OS=Homo sapiens OX=9606 GN=THOC2 PE=1 SV=2" "0.000" "False" "64.085" "13" "23" "30" "23" "1593" "182.7" "8.44" "91.76" "23" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf11262, Pf11732, Pf16134" "57187" "ENSG00000125676" "THOC2" "A6NM50; hsa:57187; Q5JZ12; Q6IN92; Q8NI27; Q9H8I6" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "0.989" "1.051" "1.037" "1.136" "1.109" "1.216" "1.293" "1.210" "1.122" "3158.2" "3123.9" "3319.5" "3274.4" "3586.7" "3502.1" "3840.5" "4085.0" "3822.4" "3544.6" "" "" "" "" "" "" "" "" "" "" "2959.3" "2585.0" "3081.7" "2531.3" "3057.2" "3346.0" "3509.2" "3627.1" "3822.4" "3413.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2468696703933973892" "False" "High" "IsMasterProtein" "P23921" "Ribonucleoside-diphosphate reductase large subunit OS=Homo sapiens OX=9606 GN=RRM1 PE=1 SV=1" "0.000" "False" "64.043" "27" "21" "39" "21" "792" "90.0" "7.15" "114.18" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00317, Pf02867, Pf03477" "6240" "ENSG00000167325" "RRM1" "hsa:6240; P23921; Q9UNN2" "Fluoropyrimidine activity; Retinoblastoma gene in cancer; Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "4" "0" "1.022" "1.061" "0.988" "1.009" "1.037" "0.940" "1.010" "1.051" "1.024" "3357.8" "3432.5" "3563.5" "3317.5" "3388.0" "3480.6" "3156.9" "3390.9" "3527.5" "3438.8" "" "" "" "" "" "" "" "" "" "" "3146.3" "2840.4" "3308.3" "2564.6" "2887.9" "3325.3" "2884.6" "3010.8" "3527.5" "3311.1" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "623640857413414358" "False" "High" "IsMasterProtein" "P61981" "14-3-3 protein gamma OS=Homo sapiens OX=9606 GN=YWHAG PE=1 SV=2" "0.000" "False" "63.876" "62" "14" "85" "9" "247" "28.3" "4.89" "213.73" "14" "stress response;signal transduction;other biological processes" "cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00244" "7532" "ENSG00000170027" "YWHAG" "hsa:7532; O70457; P35214; P61981; Q6FH52; Q9UDP2; Q9UN99" "Cell cycle; Prolactin signaling pathway; Myometrial relaxation and contraction pathways; Disruption of postsynaptic signaling by CNV; Calcium regulation in cardiac cells; 7q11.23 distal copy number variation; Sudden infant death syndrome (SIDS) susceptibility pathways" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "22" "1" "1.271" "0.993" "1.012" "0.957" "0.973" "0.857" "1.005" "1.255" "1.006" "2740.9" "3482.7" "2721.9" "2772.6" "2621.9" "2666.2" "2349.1" "2756.0" "3439.4" "2757.7" "" "" "" "" "" "" "" "" "" "" "2568.2" "2881.9" "2527.0" "2143.3" "2234.8" "2547.3" "2146.4" "2447.0" "3439.4" "2655.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2613471079569612470" "False" "High" "IsMasterProtein" "P14866" "Heterogeneous nuclear ribonucleoprotein L OS=Homo sapiens OX=9606 GN=HNRNPL PE=1 SV=2" "0.000" "False" "63.756" "38" "17" "56" "17" "589" "64.1" "8.22" "177.71" "17" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "3191" "ENSG00000104824; ENSG00000282947" "HNRNPL" "A6ND69; A6NIT8; hsa:3191; P14866; Q9H3P3" "mRNA processing; Hippocampal synaptogenesis and neurogenesis" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "4" "0" "1.004" "1.063" "1.050" "1.041" "1.058" "1.048" "1.068" "1.134" "1.065" "3282.2" "3296.4" "3489.7" "3446.5" "3416.0" "3471.2" "3440.3" "3504.9" "3720.7" "3495.4" "" "" "" "" "" "" "" "" "" "" "3075.4" "2727.7" "3239.7" "2664.3" "2911.7" "3316.4" "3143.5" "3112.0" "3720.7" "3365.5" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4678846149867540289" "False" "High" "IsMasterProtein" "Q9H4A4" "Aminopeptidase B OS=Homo sapiens OX=9606 GN=RNPEP PE=1 SV=2" "0.000" "False" "63.686" "32" "17" "29" "17" "650" "72.5" "5.74" "96.09" "17" "protein metabolism" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf01433, Pf09127, Pf17900" "6051" "ENSG00000176393" "RNPEP" "hsa:6051; Q9BVM9; Q9H1D4; Q9H4A4; Q9NPT7" "" "" "0" "0" "0.942" "1.003" "0.978" "1.008" "1.001" "0.972" "1.001" "0.996" "1.036" "2355.0" "2219.3" "2361.9" "2303.9" "2373.0" "2356.5" "2288.9" "2357.5" "2346.0" "2439.0" "" "" "" "" "" "" "" "" "" "" "2206.6" "1836.4" "2192.7" "1781.0" "2022.7" "2251.4" "2091.4" "2093.2" "2346.0" "2348.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5646758734319931850" "False" "High" "IsMasterProtein" "Q16555" "Dihydropyrimidinase-related protein 2 OS=Homo sapiens OX=9606 GN=DPYSL2 PE=1 SV=1" "0.000" "False" "63.468" "39" "17" "37" "17" "572" "62.3" "6.38" "136.03" "17" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "other molecular function" "Pf01979" "1808" "ENSG00000092964" "DPYSL2" "A8K5H2; B4DR31; D3DSS7; hsa:1808; O00424; Q16555" "Microtubule cytoskeleton regulation; Brain-derived neurotrophic factor (BDNF) signaling pathway" "Recycling pathway of L1; CRMPs in Sema3A signaling" "4" "0" "1.027" "1.004" "1.024" "0.999" "0.999" "1.008" "0.998" "1.084" "0.998" "2798.0" "2872.3" "2809.5" "2865.5" "2794.0" "2795.9" "2819.0" "2791.5" "3033.9" "2791.9" "" "" "" "" "" "" "" "" "" "" "2621.7" "2376.8" "2608.3" "2215.1" "2381.5" "2671.2" "2575.8" "2478.6" "3033.9" "2688.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2355880035621835112" "False" "High" "IsMasterProtein" "O15067" "Phosphoribosylformylglycinamidine synthase OS=Homo sapiens OX=9606 GN=PFAS PE=1 SV=4" "0.000" "False" "63.333" "16" "20" "32" "20" "1338" "144.6" "5.76" "105.78" "20" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf02769, Pf13507, Pf18072, Pf18076" "5198" "ENSG00000178921" "PFAS" "A6H8V8; hsa:5198; O15067" "" "Purine ribonucleoside monophosphate biosynthesis" "1" "0" "0.964" "0.950" "0.989" "0.959" "0.943" "0.958" "0.945" "0.931" "0.942" "3252.0" "3136.1" "3088.6" "3215.4" "3118.4" "3066.4" "3116.6" "3073.6" "3028.1" "3062.9" "" "" "" "" "" "" "" "" "" "" "3047.1" "2595.1" "2867.4" "2485.7" "2658.0" "2929.6" "2847.8" "2729.1" "3028.1" "2949.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6465314109903613014" "False" "High" "IsMasterProtein" "Q99615" "DnaJ homolog subfamily C member 7 OS=Homo sapiens OX=9606 GN=DNAJC7 PE=1 SV=2" "0.000" "False" "63.300" "45" "22" "31" "22" "494" "56.4" "6.96" "92.21" "22" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00226" "7266" "ENSG00000168259" "DNAJC7" "hsa:7266; Q7Z784; Q99615" "Constitutive androstane receptor pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway" "Regulation of HSF1-mediated heat shock response" "4" "0" "0.998" "1.000" "0.936" "0.983" "1.034" "1.031" "0.948" "0.964" "1.005" "3974.7" "3965.1" "3976.3" "3719.2" "3906.8" "4108.7" "4097.7" "3768.4" "3832.8" "3996.1" "" "" "" "" "" "" "" "" "" "" "3724.3" "3281.0" "3691.5" "2875.1" "3330.1" "3925.5" "3744.2" "3345.9" "3832.8" "3847.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1683899515612259900" "False" "High" "IsMasterProtein" "O94776" "Metastasis-associated protein MTA2 OS=Homo sapiens OX=9606 GN=MTA2 PE=1 SV=1" "0.000" "False" "63.300" "30" "20" "34" "17" "668" "75.0" "9.66" "108.13" "20" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "9219" "ENSG00000149480" "MTA2" "hsa:9219; O94776; Q68DB1; Q9UQB5" "Effect of progerin on genes involved in progeria" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "7" "2" "1.038" "1.021" "0.999" "0.995" "0.956" "1.005" "0.966" "0.956" "0.993" "3262.5" "3385.1" "3332.3" "3258.5" "3244.6" "3119.5" "3277.4" "3152.0" "3118.2" "3239.9" "" "" "" "" "" "" "" "" "" "" "3056.9" "2801.1" "3093.6" "2519.0" "2765.6" "2980.4" "2994.6" "2798.7" "3118.2" "3119.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7997158032231502372" "False" "High" "IsMasterProtein" "Q9Y6D9" "Mitotic spindle assembly checkpoint protein MAD1 OS=Homo sapiens OX=9606 GN=MAD1L1 PE=1 SV=2" "0.000" "False" "63.284" "30" "21" "26" "21" "718" "83.0" "5.92" "86.88" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05557" "8379" "ENSG00000002822" "MAD1L1" "B3KR41; hsa:8379; Q13312; Q75MI0; Q86UM4; Q9UNH0; Q9Y6D9" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; Pleural mesothelioma; CCL18 signaling pathway" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "10" "0" "1.017" "0.999" "1.051" "1.044" "1.021" "0.993" "0.973" "0.958" "1.024" "3566.3" "3626.2" "3564.3" "3748.7" "3722.6" "3640.7" "3541.9" "3471.6" "3415.6" "3652.4" "" "" "" "" "" "" "" "" "" "" "3341.6" "3000.6" "3309.0" "2897.9" "3173.1" "3478.4" "3236.4" "3082.5" "3415.6" "3516.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4468909642596951639" "False" "High" "IsMasterProtein" "Q15020" "Squamous cell carcinoma antigen recognized by T-cells 3 OS=Homo sapiens OX=9606 GN=SART3 PE=1 SV=1" "0.000" "False" "63.212" "22" "22" "33" "22" "963" "109.9" "5.57" "106.52" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf05391, Pf16605" "9733" "ENSG00000075856" "SART3" "A8K2E4; B7ZKM0; hsa:9733; Q15020; Q2M2H0; Q58F06; Q8IUS1; Q96J95" "" "" "0" "0" "0.963" "1.014" "0.955" "0.978" "0.949" "0.963" "0.948" "0.990" "0.968" "4335.3" "4176.2" "4394.6" "4139.7" "4239.0" "4114.7" "4173.4" "4111.1" "4291.2" "4197.7" "" "" "" "" "" "" "" "" "" "" "4062.1" "3455.8" "4079.8" "3200.2" "3613.2" "3931.2" "3813.4" "3650.3" "4291.2" "4041.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2402053168044673171" "False" "High" "IsMasterProtein" "P06576" "ATP synthase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1B PE=1 SV=3" "0.000" "False" "63.200" "38" "15" "31" "15" "529" "56.5" "5.40" "107.16" "15" "other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00006, Pf02874" "506" "ENSG00000110955" "ATP5F1B" "A8K4X0; hsa:506; P06576; Q14283" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein import; Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "8" "0" "1.034" "1.033" "1.089" "1.057" "1.053" "1.080" "1.095" "1.036" "1.045" "2065.2" "2134.4" "2133.7" "2249.0" "2182.4" "2174.0" "2229.8" "2261.4" "2139.1" "2159.1" "" "" "" "" "" "" "" "" "" "" "1935.1" "1766.2" "1980.8" "1738.6" "1860.2" "2077.1" "2037.5" "2007.9" "2139.1" "2078.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2002757993896463050" "False" "High" "IsMasterProtein" "Q9NQW6" "Anillin OS=Homo sapiens OX=9606 GN=ANLN PE=1 SV=2" "0.000" "False" "63.124" "18" "21" "26" "21" "1124" "124.1" "8.07" "80.53" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00169, Pf08174, Pf16018" "54443" "ENSG00000011426" "ANLN" "hsa:54443; Q5CZ78; Q6NSK5; Q9H8Y4; Q9NQW6; Q9NVN9; Q9NVP0" "Retinoblastoma gene in cancer; Nephrotic syndrome" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle" "5" "0" "0.964" "1.005" "0.947" "0.994" "1.015" "0.943" "0.976" "0.962" "1.004" "2791.7" "2692.5" "2805.8" "2644.4" "2775.4" "2832.9" "2631.7" "2723.9" "2685.6" "2802.8" "" "" "" "" "" "" "" "" "" "" "2615.8" "2228.0" "2604.9" "2044.2" "2365.6" "2706.6" "2404.7" "2418.5" "2685.6" "2698.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2914348929085593862" "False" "High" "IsMasterProtein" "Q96F07" "Cytoplasmic FMR1-interacting protein 2 OS=Homo sapiens OX=9606 GN=CYFIP2 PE=1 SV=2" "0.000" "False" "63.036" "17" "21" "27" "11" "1278" "148.3" "7.31" "85.35" "21" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05994, Pf07159" "26999" "ENSG00000055163" "CYFIP2" "A6NLT2; D3DQJ3; hsa:26999; Q53EN5; Q96F07; Q9NTK4; Q9ULQ2; Q9UN29" "Fragile X syndrome; Regulation of actin cytoskeleton" "RAC1 GTPase cycle; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "7" "9" "0.974" "1.005" "0.979" "0.988" "0.975" "0.932" "0.967" "0.935" "0.971" "4200.7" "4090.9" "4219.7" "4111.9" "4149.4" "4097.7" "3913.1" "4063.1" "3926.3" "4079.7" "" "" "" "" "" "" "" "" "" "" "3936.1" "3385.1" "3917.5" "3178.7" "3536.8" "3915.0" "3575.5" "3607.7" "3926.3" "3928.2" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7558389581764573434" "False" "High" "IsMasterProtein" "P18858" "DNA ligase 1 OS=Homo sapiens OX=9606 GN=LIG1 PE=1 SV=1" "0.000" "False" "62.854" "25" "21" "30" "21" "919" "101.7" "5.62" "106.57" "21" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01068, Pf04675, Pf04679" "3978" "ENSG00000105486" "LIG1" "B2RAI8; B4DTU4; hsa:3978; P18858; Q2TB12; Q32P23" "Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Gap-filling DNA repair synthesis and ligation in TC-NER; Early Phase of HIV Life Cycle; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Processive synthesis on the lagging strand; Gap-filling DNA repair synthesis and ligation in GG-NER; Processive synthesis on the C-strand of the telomere; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "14" "0" "1.001" "1.030" "0.982" "0.990" "1.018" "0.954" "0.992" "1.020" "1.057" "3070.1" "3073.6" "3160.7" "3016.3" "3040.0" "3124.5" "2927.4" "3045.3" "3131.0" "3245.5" "" "" "" "" "" "" "" "" "" "" "2876.7" "2543.4" "2934.3" "2331.8" "2591.2" "2985.2" "2674.9" "2703.9" "3131.0" "3125.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7081455264055243390" "False" "High" "IsMasterProtein" "Q16658" "Fascin OS=Homo sapiens OX=9606 GN=FSCN1 PE=1 SV=3" "0.000" "False" "62.734" "34" "17" "36" "17" "493" "54.5" "7.24" "115.04" "17" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf06268" "6624" "ENSG00000075618" "FSCN1" "A6NI89; B2RE97; hsa:6624; Q16658; Q96IC5; Q96IH1; Q9BRF1" "VEGFA-VEGFR2 signaling; Urotensin-II-mediated signaling pathway" "Interleukin-4 and Interleukin-13 signaling" "3" "0" "1.010" "1.018" "1.021" "0.978" "0.980" "0.989" "1.033" "0.999" "0.981" "2043.9" "2065.1" "2081.0" "2087.4" "1997.9" "2003.1" "2020.6" "2112.0" "2042.4" "2005.3" "" "" "" "" "" "" "" "" "" "" "1915.1" "1708.8" "1932.0" "1613.6" "1703.0" "1913.7" "1846.3" "1875.2" "2042.4" "1930.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8980263924004467581" "False" "High" "IsMasterProtein" "P28340" "DNA polymerase delta catalytic subunit OS=Homo sapiens OX=9606 GN=POLD1 PE=1 SV=2" "0.000" "False" "62.378" "19" "22" "32" "21" "1107" "123.6" "7.03" "101.41" "22" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00136, Pf03104, Pf14260" "5424" "ENSG00000062822" "POLD1" "hsa:5424; P28340; Q8NER3; Q96H98" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Progeria-associated lipodystrophy; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Cytosolic iron-sulfur cluster assembly; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "27" "0" "0.965" "0.967" "0.973" "1.000" "0.960" "0.917" "0.905" "0.916" "0.958" "3160.0" "3048.4" "3056.3" "3074.6" "3158.8" "3034.9" "2896.3" "2860.5" "2895.2" "3028.6" "" "" "" "" "" "" "" "" "" "" "2960.9" "2522.6" "2837.4" "2376.8" "2692.5" "2899.6" "2646.4" "2539.8" "2895.2" "2916.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1479790111935506116" "False" "High" "IsMasterProtein" "Q9P258" "Protein RCC2 OS=Homo sapiens OX=9606 GN=RCC2 PE=1 SV=2" "0.000" "False" "62.206" "36" "17" "31" "17" "522" "56.0" "8.78" "103.42" "17" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00415" "55920" "ENSG00000179051; ENSG00000281540" "RCC2" "hsa:55920; Q8IVL9; Q9BSN6; Q9NPV8; Q9P258" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.079" "1.032" "1.064" "0.999" "1.028" "1.012" "1.018" "1.031" "1.016" "3988.1" "4302.4" "4115.4" "4243.8" "3983.1" "4101.7" "4036.7" "4058.4" "4112.2" "4052.8" "" "" "" "" "" "" "" "" "" "" "3736.8" "3560.2" "3820.7" "3280.7" "3395.1" "3918.8" "3688.5" "3603.5" "4112.2" "3902.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8488092828150113306" "False" "High" "IsMasterProtein" "Q86UX7" "Fermitin family homolog 3 OS=Homo sapiens OX=9606 GN=FERMT3 PE=1 SV=1" "0.000" "False" "61.856" "31" "17" "34" "17" "667" "75.9" "6.98" "122.66" "17" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00169, Pf00373, Pf18124" "83706" "ENSG00000149781" "FERMT3" "hsa:83706; Q86UX7; Q8IUA1; Q8N207; Q9BT48" "Leukocyte-intrinsic Hippo pathway functions" "Platelet degranulation" "2" "0" "0.981" "1.049" "0.937" "1.013" "1.019" "0.913" "0.990" "1.028" "0.995" "3195.8" "3136.1" "3352.1" "2995.8" "3238.9" "3257.9" "2917.3" "3164.9" "3286.7" "3180.4" "" "" "" "" "" "" "" "" "" "" "2994.5" "2595.1" "3112.0" "2315.9" "2760.8" "3112.6" "2665.6" "2810.1" "3286.7" "3062.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8610404900026586522" "False" "High" "IsMasterProtein" "P27797" "Calreticulin OS=Homo sapiens OX=9606 GN=CALR PE=1 SV=1" "0.000" "False" "61.677" "35" "20" "45" "20" "417" "48.1" "4.44" "148.03" "20" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00262" "811" "ENSG00000179218" "CALR" "hsa:811; P27797; Q6IAT4; Q9UDG2" "Androgen receptor signaling pathway; Complement system; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling; GDNF signaling; Calcium regulation in cardiac cells" "ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Scavenging by Class A Receptors; Assembly of Viral Components at the Budding Site; Scavenging by Class F Receptors; ATF6 (ATF6-alpha) activates chaperone genes; Calnexin/calreticulin cycle" "13" "0" "0.957" "0.974" "0.918" "0.946" "0.963" "0.939" "0.990" "0.916" "0.973" "8316.0" "7958.3" "8099.6" "7634.4" "7870.0" "8006.7" "7804.9" "8232.0" "7618.8" "8094.8" "" "" "" "" "" "" "" "" "" "" "7792.1" "6585.4" "7519.4" "5901.7" "6708.2" "7649.6" "7131.6" "7309.1" "7618.8" "7794.2" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2037005348220660879" "False" "High" "IsMasterProtein" "O00151" "PDZ and LIM domain protein 1 OS=Homo sapiens OX=9606 GN=PDLIM1 PE=1 SV=4" "0.000" "False" "61.546" "51" "14" "39" "14" "329" "36.0" "7.02" "147.49" "14" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595, Pf15936" "9124" "ENSG00000107438" "PDLIM1" "B2RBS6; hsa:9124; O00151; Q5VZH5; Q9BPZ9" "" "" "0" "0" "1.075" "1.043" "1.086" "1.013" "0.929" "0.999" "0.999" "0.956" "1.006" "3780.3" "4065.5" "3944.7" "4106.9" "3829.2" "3513.4" "3776.8" "3778.1" "3615.6" "3801.5" "" "" "" "" "" "" "" "" "" "" "3542.2" "3364.1" "3662.1" "3174.8" "3263.9" "3356.7" "3451.0" "3354.5" "3615.6" "3660.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8154313858001218704" "False" "High" "IsMasterProtein" "Q8IWZ3" "Ankyrin repeat and KH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKHD1 PE=1 SV=1" "0.000" "False" "61.511" "8" "19" "23" "13" "2542" "269.3" "5.73" "71.11" "19" "stress response" "other cell component" "" "Pf00013, Pf12796, Pf13637" "404734; 54882" "ENSG00000131503" "ANKHD1" "A6NH85; hsa:404734; hsa:54882; Q149P2; Q8IWZ2; Q8IWZ3; Q8WY90; Q96G77; Q96GK0; Q9H2U0; Q9HA95; Q9NWG4; Q9UPR7" "" "" "0" "4" "0.995" "1.004" "1.053" "1.033" "1.005" "1.091" "1.060" "1.033" "1.043" "1734.5" "1726.1" "1740.9" "1826.2" "1791.8" "1743.7" "1891.5" "1838.7" "1791.9" "1808.3" "" "" "" "" "" "" "" "" "" "" "1625.2" "1428.3" "1616.2" "1411.7" "1527.3" "1666.0" "1728.3" "1632.6" "1791.9" "1741.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8372900262212064526" "False" "High" "IsMasterProtein" "P09651" "Heterogeneous nuclear ribonucleoprotein A1 OS=Homo sapiens OX=9606 GN=HNRNPA1 PE=1 SV=5" "0.000" "False" "61.407" "44" "15" "94" "11" "372" "38.7" "9.13" "279.31" "15" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11627" "3178" "ENSG00000135486" "HNRNPA1" "A8K4Z8; hsa:3178; P09651; Q3MIB7; Q6PJZ7" "mRNA processing" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; SARS-CoV-1-host interactions; SARS-CoV-1 modulates host translation machinery" "6" "0" "1.105" "0.999" "1.114" "1.041" "0.982" "1.014" "0.986" "1.025" "1.017" "3542.5" "3914.3" "3537.9" "3944.6" "3688.7" "3477.0" "3593.0" "3493.1" "3629.8" "3604.4" "" "" "" "" "" "" "" "" "" "" "3319.3" "3239.1" "3284.5" "3049.4" "3144.1" "3322.0" "3283.0" "3101.5" "3629.8" "3470.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5070657134179306573" "False" "High" "IsMasterProtein" "P55160" "Nck-associated protein 1-like OS=Homo sapiens OX=9606 GN=NCKAP1L PE=1 SV=3" "0.000" "False" "61.379" "19" "21" "29" "21" "1127" "128.1" "6.86" "84.40" "21" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf09735" "3071" "ENSG00000123338" "NCKAP1L" "B4DUT5; hsa:3071; P55160; Q52LW0" "Hematopoietic stem cell differentiation; Microglia pathogen phagocytosis pathway; TYROBP causal network in microglia" "Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "11" "0" "1.018" "1.065" "1.034" "1.042" "1.008" "0.999" "1.016" "1.029" "1.051" "2093.0" "2131.2" "2229.8" "2164.4" "2181.2" "2109.6" "2091.4" "2126.3" "2153.1" "2200.7" "" "" "" "" "" "" "" "" "" "" "1961.1" "1763.6" "2070.1" "1673.2" "1859.2" "2015.5" "1911.0" "1888.0" "2153.1" "2118.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6174842833444890787" "False" "High" "IsMasterProtein" "Q99613" "Eukaryotic translation initiation factor 3 subunit C OS=Homo sapiens OX=9606 GN=EIF3C PE=1 SV=1" "0.000" "False" "61.241" "20" "20" "29" "19" "913" "105.3" "5.68" "98.35" "20" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf01399, Pf05470" "8663" "ENSG00000184110" "EIF3C" "A8K7Z0; B2RXG3; B4E1D5; H3BRV0; hsa:8663; O00215; Q99613; Q9BW98" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "1" "1.015" "0.995" "0.956" "0.919" "0.894" "1.256" "1.147" "1.083" "1.037" "3231.2" "3279.3" "3216.5" "3089.5" "2968.0" "2890.2" "4058.6" "3706.2" "3499.0" "3349.8" "" "" "" "" "" "" "" "" "" "" "3027.7" "2713.6" "2986.1" "2388.3" "2529.8" "2761.3" "3708.5" "3290.8" "3499.0" "3225.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4685450292699183556" "False" "High" "IsMasterProtein" "P43246" "DNA mismatch repair protein Msh2 OS=Homo sapiens OX=9606 GN=MSH2 PE=1 SV=1" "0.000" "False" "61.222" "21" "21" "33" "21" "934" "104.7" "5.77" "104.47" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00488, Pf01624, Pf05188, Pf05190, Pf05192" "4436" "ENSG00000095002" "MSH2" "B4E2Z2; hsa:4436; O75488; P43246" "RAC1/PAK1/p38/MMP2 pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ciliary landscape; DNA repair pathways, full network; p53 transcriptional gene network; DNA mismatch repair" "TP53 Regulates Transcription of DNA Repair Genes; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6" "12" "0" "0.986" "0.996" "0.983" "0.990" "0.973" "0.974" "0.992" "0.984" "1.013" "3352.0" "3305.1" "3339.0" "3296.2" "3318.2" "3261.0" "3265.4" "3324.9" "3298.1" "3397.0" "" "" "" "" "" "" "" "" "" "" "3140.8" "2734.9" "3099.8" "2548.1" "2828.4" "3115.6" "2983.7" "2952.2" "3298.1" "3270.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9204758010535676815" "False" "High" "IsMasterProtein" "Q641Q2" "WASH complex subunit 2A OS=Homo sapiens OX=9606 GN=WASHC2A PE=1 SV=3" "0.000" "False" "61.075" "19" "19" "24" "4" "1341" "147.1" "4.81" "75.02" "19" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15255" "387680" "ENSG00000099290" "WASHC2A" "A2A3S2; A2A3U6; hsa:387680; Q5SNT6; Q641Q2; Q6DHY0" "" "" "0" "11" "1.019" "1.023" "1.013" "1.022" "0.982" "1.012" "1.010" "1.020" "1.059" "1919.8" "1956.0" "1963.7" "1944.0" "1962.1" "1885.4" "1943.2" "1938.3" "1959.1" "2033.9" "" "" "" "" "" "" "" "" "" "" "1798.9" "1618.6" "1823.1" "1502.8" "1672.4" "1801.4" "1775.6" "1721.0" "1959.1" "1958.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5279545747934132258" "False" "High" "IsMasterProtein" "P04350" "Tubulin beta-4A chain OS=Homo sapiens OX=9606 GN=TUBB4A PE=1 SV=2" "0.000" "False" "61.074" "36" "14" "75" "1" "444" "49.6" "4.88" "188.28" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "10382" "ENSG00000104833" "TUBB4A" "B3KQP4; hsa:10382; P04350; Q969E5" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "41" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5909350322516910922" "False" "High" "IsMasterProtein" "P40222" "Alpha-taxilin OS=Homo sapiens OX=9606 GN=TXLNA PE=1 SV=3" "0.000" "False" "60.878" "36" "20" "27" "20" "546" "61.9" "6.52" "86.27" "20" "transport;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf09728" "200081" "ENSG00000084652" "TXLNA" "D3DPP6; hsa:200081; P40222; Q5TFJ6; Q66K62; Q86T54; Q86T85; Q86T86; Q86Y86; Q86YW3; Q8N2Y3" "" "Other interleukin signaling" "1" "0" "1.052" "0.991" "0.968" "1.032" "1.014" "1.018" "0.988" "0.939" "0.980" "2950.6" "3103.8" "2925.2" "2857.6" "3044.8" "2990.8" "3003.3" "2915.5" "2770.7" "2892.8" "" "" "" "" "" "" "" "" "" "" "2764.7" "2568.3" "2715.6" "2209.0" "2595.3" "2857.4" "2744.2" "2588.7" "2770.7" "2785.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951583387108982266" "False" "High" "IsMasterProtein" "P11171" "Protein 4.1 OS=Homo sapiens OX=9606 GN=EPB41 PE=1 SV=4" "0.000" "False" "60.848" "20" "17" "24" "16" "864" "97.0" "5.58" "72.64" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" "2035" "ENSG00000159023" "EPB41" "B1ALH8; B1ALH9; D3DPM9; D3DPN0; hsa:2035; P11171; P11176; Q14245; Q5TB35; Q5VXN8; Q8IXV9; Q9Y578; Q9Y579" "VEGFA-VEGFR2 signaling; Splicing factor NOVA regulated synaptic proteins; IL-18 signaling pathway" "Neurexins and neuroligins" "4" "0" "0.945" "0.993" "0.930" "0.980" "0.972" "0.915" "0.920" "0.950" "0.964" "2871.4" "2712.3" "2850.0" "2671.0" "2813.5" "2791.6" "2626.1" "2641.8" "2728.3" "2767.8" "" "" "" "" "" "" "" "" "" "" "2690.5" "2244.4" "2645.9" "2064.8" "2398.1" "2667.1" "2399.5" "2345.6" "2728.3" "2665.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7021380242978739287" "False" "High" "IsMasterProtein" "Q92797" "Symplekin OS=Homo sapiens OX=9606 GN=SYMPK PE=1 SV=2" "0.000" "False" "60.784" "16" "22" "28" "22" "1274" "141.1" "6.13" "95.11" "22" "cell adhesion;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf11935, Pf12295" "8189" "ENSG00000125755" "SYMPK" "hsa:8189; O00521; O00689; O00733; Q59GT5; Q8N2U5; Q92797" "" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "0.944" "0.988" "1.039" "1.057" "1.062" "1.179" "1.191" "1.140" "1.104" "3469.4" "3276.0" "3429.1" "3605.5" "3667.2" "3684.0" "4089.6" "4131.6" "3956.5" "3829.8" "" "" "" "" "" "" "" "" "" "" "3250.8" "2710.8" "3183.5" "2787.3" "3125.9" "3519.7" "3736.8" "3668.4" "3956.5" "3687.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8282495750123490209" "False" "High" "IsMasterProtein" "Q96AE4" "Far upstream element-binding protein 1 OS=Homo sapiens OX=9606 GN=FUBP1 PE=1 SV=3" "0.000" "False" "60.773" "30" "19" "38" "15" "644" "67.5" "7.61" "119.96" "19" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00013, Pf09005" "8880" "ENSG00000162613" "FUBP1" "hsa:8880; Q12828; Q96AE4" "" "" "0" "1" "1.088" "0.971" "0.944" "0.987" "1.024" "1.036" "1.017" "0.974" "0.982" "4434.5" "4824.8" "4304.8" "4185.7" "4379.0" "4541.4" "4595.7" "4511.7" "4317.1" "4353.4" "" "" "" "" "" "" "" "" "" "" "4155.1" "3992.5" "3996.5" "3235.7" "3732.5" "4338.9" "4199.3" "4005.9" "4317.1" "4191.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562361449972294003" "False" "High" "IsMasterProtein" "O00425" "Insulin-like growth factor 2 mRNA-binding protein 3 OS=Homo sapiens OX=9606 GN=IGF2BP3 PE=1 SV=2" "0.000" "False" "60.679" "34" "19" "29" "19" "579" "63.7" "8.87" "100.16" "19" "protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00076" "10643" "ENSG00000136231" "IGF2BP3" "A0A4Z5; hsa:10643; O00425; Q63HM0; Q6MZZ2; Q86VB1" "" "Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA" "1" "0" "0.983" "1.000" "0.955" "0.995" "0.962" "0.855" "0.866" "0.915" "0.981" "2936.4" "2885.1" "2935.0" "2803.7" "2921.8" "2823.5" "2509.6" "2542.6" "2686.9" "2879.8" "" "" "" "" "" "" "" "" "" "" "2751.4" "2387.4" "2724.7" "2167.4" "2490.5" "2697.6" "2293.1" "2257.5" "2686.9" "2772.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5198752139468277763" "False" "High" "IsMasterProtein" "Q96PK6" "RNA-binding protein 14 OS=Homo sapiens OX=9606 GN=RBM14 PE=1 SV=2" "0.000" "False" "60.647" "28" "19" "35" "19" "669" "69.4" "9.67" "99.27" "19" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00076" "100526737; 10432" "ENSG00000239306" "RBM14" "B0LM41; B3KMN4; D6RGD8; hsa:100526737; hsa:10432; O75932; Q2PYN1; Q53GV1; Q68DQ9; Q96PK5; Q96PK6" "Ciliary landscape" "RUNX2 regulates bone development" "2" "0" "0.985" "1.026" "0.988" "1.032" "1.058" "0.973" "1.012" "1.019" "1.039" "2784.5" "2743.5" "2856.6" "2750.0" "2873.6" "2945.6" "2708.1" "2817.9" "2838.0" "2893.2" "" "" "" "" "" "" "" "" "" "" "2609.1" "2270.3" "2652.0" "2125.9" "2449.4" "2814.2" "2474.5" "2502.0" "2838.0" "2785.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "454806171855366482" "False" "High" "IsMasterProtein" "P40939" "Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=HADHA PE=1 SV=2" "0.000" "False" "60.543" "26" "19" "27" "19" "763" "82.9" "9.04" "77.41" "19" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00378, Pf00725, Pf02737" "3030" "ENSG00000084754" "HADHA" "B2R7L4; B4DYP2; hsa:3030; P40939; Q16679; Q53T69; Q53TA2; Q96GT7; Q9UQC5" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Valproic acid pathway; Mitochondrial fatty acid oxidation disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "Acyl chain remodeling of CL; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "13" "0" "0.978" "0.998" "0.927" "0.994" "1.012" "0.948" "0.971" "0.963" "0.989" "3670.8" "3591.4" "3664.2" "3403.7" "3647.9" "3715.9" "3479.4" "3565.3" "3535.9" "3630.0" "" "" "" "" "" "" "" "" "" "" "3439.5" "2971.9" "3401.8" "2631.2" "3109.4" "3550.2" "3179.3" "3165.6" "3535.9" "3495.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "715968340642640214" "False" "High" "IsMasterProtein" "Q9H9A6" "Leucine-rich repeat-containing protein 40 OS=Homo sapiens OX=9606 GN=LRRC40 PE=1 SV=1" "0.000" "False" "60.534" "36" "20" "26" "20" "602" "68.2" "6.43" "92.41" "20" "signal transduction" "" "" "Pf00560, Pf13855" "55631" "ENSG00000066557" "LRRC40" "hsa:55631; Q9BTR7; Q9H9A6; Q9NSK1; Q9NXC1" "" "" "0" "0" "0.983" "1.016" "0.997" "1.011" "1.008" "0.985" "0.980" "0.983" "1.011" "3201.8" "3147.4" "3252.7" "3191.3" "3238.5" "3229.0" "3154.3" "3138.0" "3147.8" "3236.9" "" "" "" "" "" "" "" "" "" "" "3000.1" "2604.4" "3019.7" "2467.1" "2760.4" "3085.0" "2882.2" "2786.3" "3147.8" "3116.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3995603134814959224" "False" "High" "IsMasterProtein" "Q9NRL2" "Bromodomain adjacent to zinc finger domain protein 1A OS=Homo sapiens OX=9606 GN=BAZ1A PE=1 SV=2" "0.000" "False" "60.520" "13" "20" "26" "20" "1556" "178.6" "6.60" "76.38" "20" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf02791, Pf10537, Pf15612, Pf15613" "11177" "ENSG00000198604" "BAZ1A" "hsa:11177; Q9NRL2; Q9NZ15; Q9P065; Q9UIG1; Q9Y3V3" "Ectoderm differentiation" "" "1" "0" "1.004" "1.080" "1.031" "1.060" "1.053" "1.027" "1.004" "1.016" "1.070" "2595.8" "2606.9" "2804.7" "2675.2" "2752.8" "2733.0" "2666.6" "2606.2" "2638.2" "2776.5" "" "" "" "" "" "" "" "" "" "" "2432.3" "2157.2" "2603.8" "2068.0" "2346.4" "2611.1" "2436.6" "2314.0" "2638.2" "2673.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8840476301148053294" "False" "High" "IsMasterProtein" "Q9NVI1" "Fanconi anemia group I protein OS=Homo sapiens OX=9606 GN=FANCI PE=1 SV=4" "0.000" "False" "60.415" "16" "19" "26" "19" "1328" "149.2" "6.74" "85.99" "19" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf14674, Pf14675, Pf14676, Pf14677, Pf14678, Pf14679, Pf14680" "55215" "ENSG00000140525" "FANCI" "A4ZVE4; A5YMH4; A6NJZ0; hsa:55215; Q96JN1; Q96ST0; Q9BT96; Q9NVI1" "Gastric cancer network 2; DNA repair pathways, full network; 15q11q13 copy number variation" "Fanconi Anemia Pathway; TP53 Regulates Transcription of DNA Repair Genes" "5" "0" "0.967" "0.978" "0.962" "0.999" "0.987" "0.963" "0.966" "0.961" "0.986" "3059.3" "2958.0" "2990.5" "2941.7" "3056.9" "3019.7" "2945.1" "2955.3" "2941.1" "3017.9" "" "" "" "" "" "" "" "" "" "" "2866.6" "2447.7" "2776.3" "2274.0" "2605.6" "2885.0" "2691.1" "2624.0" "2941.1" "2905.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4866414538171077072" "False" "High" "IsMasterProtein" "P31146" "Coronin-1A OS=Homo sapiens OX=9606 GN=CORO1A PE=1 SV=4" "0.000" "False" "60.309" "32" "17" "35" "17" "461" "51.0" "6.68" "119.63" "17" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf08954, Pf16300" "11151" "ENSG00000102879" "CORO1A" "B2RBL1; hsa:11151; P31146; Q2YD73" "16p11.2 proximal deletion syndrome" "Prevention of phagosomal-lysosomal fusion" "2" "0" "1.055" "1.003" "0.995" "0.955" "0.982" "0.956" "1.004" "0.975" "0.980" "3877.5" "4090.2" "3889.9" "3859.7" "3701.5" "3807.0" "3707.6" "3892.3" "3778.7" "3799.4" "" "" "" "" "" "" "" "" "" "" "3633.2" "3384.6" "3611.2" "2983.7" "3155.1" "3637.2" "3387.7" "3456.0" "3778.7" "3658.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5216339322949848557" "False" "High" "IsMasterProtein" "Q96PZ0" "Pseudouridylate synthase 7 homolog OS=Homo sapiens OX=9606 GN=PUS7 PE=1 SV=2" "0.000" "False" "60.289" "34" "19" "24" "19" "661" "75.0" "6.37" "78.07" "19" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01142" "54517" "ENSG00000091127" "PUS7" "hsa:54517; Q75MG4; Q96PZ0; Q9NX19" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.131" "1.029" "1.043" "1.052" "1.037" "0.985" "1.020" "1.093" "1.045" "2434.7" "2754.4" "2506.3" "2539.9" "2561.7" "2524.4" "2398.9" "2482.3" "2660.3" "2545.3" "" "" "" "" "" "" "" "" "" "" "2281.3" "2279.2" "2326.7" "1963.5" "2183.6" "2411.8" "2192.0" "2204.0" "2660.3" "2450.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4621514541592481866" "False" "High" "IsMasterProtein" "O75376" "Nuclear receptor corepressor 1 OS=Homo sapiens OX=9606 GN=NCOR1 PE=1 SV=2" "0.000" "False" "59.834" "8" "21" "25" "19" "2440" "270.0" "7.11" "79.76" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf15784" "9611" "ENSG00000141027" "NCOR1" "B3DLF8; E9PGV6; hsa:9611; O75376; Q86YY0; Q9UPV5; Q9UQ18" "Androgen receptor signaling pathway; Adipogenesis; Ovarian infertility; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Rett syndrome; 22q11.2 copy number variation syndrome; Notch signaling pathway" "HDACs deacetylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Nuclear signaling by ERBB4; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NR1D1 (REV-ERBA) represses gene expression; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis" "30" "1" "0.993" "1.008" "1.008" "1.043" "1.004" "0.986" "0.957" "0.937" "0.998" "2135.3" "2120.6" "2152.8" "2152.7" "2226.6" "2143.9" "2104.9" "2042.4" "2000.9" "2131.9" "" "" "" "" "" "" "" "" "" "" "2000.8" "1754.8" "1998.6" "1664.1" "1897.9" "2048.3" "1923.4" "1813.4" "2000.9" "2052.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4010508153477037857" "False" "High" "IsMasterProtein" "Q14103" "Heterogeneous nuclear ribonucleoprotein D0 OS=Homo sapiens OX=9606 GN=HNRNPD PE=1 SV=1" "0.000" "False" "59.722" "38" "15" "44" "12" "355" "38.4" "7.81" "120.42" "15" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08143" "3184" "ENSG00000138668" "HNRNPD" "A8K9J2; hsa:3184; P07029; Q01858; Q14100; Q14101; Q14102; Q14103; Q4W5A1; Q9UCE8; Q9UCE9" "mRNA processing" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "3" "3" "1.192" "1.011" "1.098" "1.025" "0.989" "1.114" "1.026" "1.073" "1.010" "3176.0" "3786.8" "3211.0" "3488.8" "3253.8" "3142.1" "3536.9" "3258.7" "3409.2" "3207.9" "" "" "" "" "" "" "" "" "" "" "2975.9" "3133.5" "2981.0" "2697.0" "2773.5" "3002.0" "3231.8" "2893.4" "3409.2" "3088.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4155367153969888648" "False" "High" "IsMasterProtein" "Cont_P13645" "Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6" "0.000" "True" "59.694" "33" "19" "26" "15" "584" "58.8" "5.21" "80.61" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038" "3858" "ENSG00000186395" "KRT10" "hsa:3858; P13645; Q14664; Q8N175" "" "Formation of the cornified envelope" "2" "2" "0.856" "0.373" "0.979" "0.411" "0.402" "3.258" "0.413" "0.294" "0.869" "3283.2" "2809.5" "1223.4" "3214.8" "1348.9" "1319.9" "10695.2" "1357.4" "965.1" "2853.3" "" "" "" "" "" "" "" "" "" "" "3076.4" "2324.8" "1135.8" "2485.2" "1149.7" "1261.0" "9772.5" "1205.2" "965.1" "2747.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7722253779426460975" "False" "High" "IsMasterProtein" "O00571" "ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=3" "0.000" "False" "59.503" "28" "18" "32" "16" "662" "73.2" "7.18" "89.03" "18" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1654" "ENSG00000215301" "DDX3X" "A8K538; B4E3E8; hsa:1654; O00571; O15536" "Novel intracellular components of RIG-I-like receptor pathway; Hepatitis B infection" "Neutrophil degranulation" "3" "1" "1.041" "1.079" "1.150" "1.116" "1.115" "1.230" "1.285" "1.142" "1.111" "2151.6" "2238.8" "2320.9" "2474.4" "2400.2" "2399.6" "2645.8" "2765.9" "2457.1" "2390.3" "" "" "" "" "" "" "" "" "" "" "2016.0" "1852.6" "2154.7" "1912.9" "2045.9" "2292.6" "2417.5" "2455.8" "2457.1" "2301.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6184402302268645522" "False" "High" "IsMasterProtein" "Q5JRX3" "Presequence protease, mitochondrial OS=Homo sapiens OX=9606 GN=PITRM1 PE=1 SV=3" "0.000" "False" "59.129" "18" "19" "29" "19" "1037" "117.3" "6.92" "94.39" "19" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "enzyme regulator activity;other molecular function" "Pf00675, Pf05193, Pf08367" "10531" "ENSG00000107959" "PITRM1" "B3KMJ6; B4E0J8; C9JSL2; E7ES23; hsa:10531; O95204; Q2M2G6; Q4VBR1; Q5JRW7; Q5JRX3; Q7L5Z7; Q9BSI6; Q9BVJ5; Q9UPP8" "" "Mitochondrial protein import" "1" "0" "0.997" "1.009" "1.037" "1.051" "0.974" "1.050" "1.026" "1.016" "1.007" "2489.3" "2482.5" "2511.7" "2581.4" "2616.5" "2425.4" "2612.7" "2554.7" "2528.6" "2507.0" "" "" "" "" "" "" "" "" "" "" "2332.4" "2054.2" "2331.8" "1995.5" "2230.2" "2317.2" "2387.3" "2268.3" "2528.6" "2413.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7738217365816998519" "False" "High" "IsMasterProtein" "P41250" "Glycine--tRNA ligase OS=Homo sapiens OX=9606 GN=GARS1 PE=1 SV=3" "0.000" "False" "59.016" "23" "19" "36" "19" "739" "83.1" "7.03" "115.36" "19" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "non-structural extracellular;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00458, Pf00587, Pf03129" "2617" "ENSG00000106105" "GARS1" "A0A090N8G0; B3KQA2; B4DIA0; hsa:2617; P41250; Q969Y1" "HDAC6 interactions in the central nervous system" "Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "3" "0" "1.032" "0.990" "0.979" "0.944" "0.954" "0.912" "0.931" "0.985" "0.949" "3603.5" "3718.4" "3567.5" "3526.3" "3402.1" "3438.6" "3285.4" "3355.7" "3550.4" "3419.9" "" "" "" "" "" "" "" "" "" "" "3376.4" "3076.9" "3311.9" "2726.0" "2899.8" "3285.3" "3002.0" "2979.5" "3550.4" "3292.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6945972540220555835" "False" "High" "IsMasterProtein" "Q96ST3" "Paired amphipathic helix protein Sin3a OS=Homo sapiens OX=9606 GN=SIN3A PE=1 SV=2" "0.000" "False" "58.999" "16" "20" "25" "20" "1273" "145.1" "7.25" "75.68" "20" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02671, Pf08295, Pf16879" "25942" "ENSG00000169375" "SIN3A" "B2RNS5; Q8N8N4; Q8NC83; Q8WV18; Q96L98; Q96ST3; Q9UFQ1" "Androgen receptor signaling pathway; Retinoblastoma gene in cancer; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; Transcription co-factors SKI and SKIL protein partners; Hedgehog signaling pathway; 15q11q13 copy number variation" "Factors involved in megakaryocyte development and platelet production; NoRC negatively regulates rRNA expression; STAT3 nuclear events downstream of ALK signaling; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SUMOylation of transcription cofactors; Cytoprotection by HMOX1; MECP2 regulates transcription of neuronal ligands; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of lipid metabolism by PPARalpha; Regulation of MECP2 expression and activity; MECP2 regulates neuronal receptors and channels; Loss of MECP2 binding ability to 5mC-DNA" "19" "0" "0.981" "1.019" "0.967" "1.027" "0.981" "1.004" "0.993" "0.979" "0.992" "3079.5" "3020.5" "3139.3" "2978.6" "3162.0" "3020.6" "3092.2" "3059.0" "3016.2" "3056.2" "" "" "" "" "" "" "" "" "" "" "2885.5" "2499.4" "2914.5" "2302.6" "2695.2" "2885.9" "2825.4" "2716.1" "3016.2" "2942.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174373993236338878" "False" "High" "IsMasterProtein" "Q15233" "Non-POU domain-containing octamer-binding protein OS=Homo sapiens OX=9606 GN=NONO PE=1 SV=4" "0.000" "False" "58.967" "31" "16" "61" "14" "471" "54.2" "8.95" "153.85" "16" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08075" "4841" "ENSG00000147140" "NONO" "B7Z4C2; D3DVV4; F5GYZ3; hsa:4841; O00201; P30807; Q12786; Q15233; Q9BQC5" "mRNA processing" "" "1" "0" "1.023" "1.066" "1.092" "1.027" "1.000" "1.014" "1.014" "1.083" "1.042" "3355.6" "3431.7" "3578.3" "3663.8" "3446.5" "3354.8" "3401.1" "3403.7" "3635.1" "3495.2" "" "" "" "" "" "" "" "" "" "" "3144.2" "2839.7" "3322.0" "2832.3" "2937.7" "3205.2" "3107.7" "3022.1" "3635.1" "3365.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7233412111740596343" "False" "High" "IsMasterProtein" "P19367" "Hexokinase-1 OS=Homo sapiens OX=9606 GN=HK1 PE=1 SV=3" "0.000" "False" "58.930" "22" "20" "26" "18" "917" "102.4" "6.80" "70.84" "20" "other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00349, Pf03727" "3098" "ENSG00000156515" "HK1" "E9PCK0; hsa:3098; O43443; O43444; O75574; P19367; Q5VTC3; Q96HC8; Q9NNZ4; Q9NNZ5" "Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Disorders of fructose metabolism; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "Glycolysis; Defective HK1 causes hexokinase deficiency (HK deficiency)" "12" "2" "1.039" "1.049" "1.052" "1.032" "1.067" "1.058" "1.058" "1.093" "1.040" "2466.3" "2563.2" "2587.0" "2595.2" "2545.0" "2632.0" "2609.2" "2610.0" "2695.3" "2565.6" "" "" "" "" "" "" "" "" "" "" "2311.0" "2121.0" "2401.7" "2006.2" "2169.3" "2514.7" "2384.1" "2317.4" "2695.3" "2470.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "117262061430317364" "False" "High" "IsMasterProtein" "Q96T88" "E3 ubiquitin-protein ligase UHRF1 OS=Homo sapiens OX=9606 GN=UHRF1 PE=1 SV=1" "0.000" "False" "58.927" "28" "18" "29" "18" "793" "89.8" "7.56" "98.33" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00628, Pf02182, Pf12148" "29128" "ENSG00000276043" "UHRF1" "A0JBR2; A8K024; B2RBA9; Q2HIX7; Q8J022; Q96T88; Q9H6S6; Q9P115; Q9P1U7" "Pathways affected in adenoid cystic carcinoma; Pleural mesothelioma" "Chromatin modifications during the maternal to zygotic transition (MZT); DNA methylation" "4" "0" "1.074" "1.050" "1.068" "1.074" "1.020" "1.157" "1.125" "1.122" "1.062" "2541.8" "2729.5" "2668.1" "2715.8" "2728.9" "2591.5" "2941.9" "2860.6" "2852.6" "2700.1" "" "" "" "" "" "" "" "" "" "" "2381.7" "2258.6" "2477.0" "2099.4" "2326.0" "2475.9" "2688.1" "2539.9" "2852.6" "2599.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8312610725791659305" "False" "High" "IsMasterProtein" "P17812" "CTP synthase 1 OS=Homo sapiens OX=9606 GN=CTPS1 PE=1 SV=2" "0.000" "False" "58.740" "28" "18" "25" "15" "591" "66.6" "6.46" "87.02" "18" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00117, Pf06418, Pf07722" "1503" "ENSG00000171793" "CTPS1" "B4DR64; D3DPW1; hsa:1503; P17812; Q5VW67; Q96GK6" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "3" "0.985" "0.962" "0.948" "0.940" "0.956" "0.928" "0.933" "0.946" "0.942" "3893.4" "3833.3" "3746.6" "3691.2" "3660.9" "3722.0" "3614.7" "3630.6" "3681.6" "3667.0" "" "" "" "" "" "" "" "" "" "" "3648.1" "3172.0" "3478.3" "2853.4" "3120.4" "3556.0" "3302.9" "3223.6" "3681.6" "3530.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8117017983706301691" "False" "High" "IsMasterProtein" "P27348" "14-3-3 protein theta OS=Homo sapiens OX=9606 GN=YWHAQ PE=1 SV=1" "0.000" "False" "58.669" "66" "15" "69" "9" "245" "27.7" "4.78" "174.72" "15" "signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00244" "10971" "ENSG00000134308" "YWHAQ" "D6W4Z5; hsa:10971; P27348; Q567U5; Q5TZU8; Q9UP48" "Cell cycle; Pathogenic Escherichia coli infection; Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Leukocyte-intrinsic Hippo pathway functions; Hepatitis B infection; Opioid receptor pathways; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "19" "2" "1.019" "0.982" "0.922" "0.928" "0.967" "0.954" "0.992" "1.072" "1.000" "1208.9" "1231.9" "1187.4" "1114.8" "1122.4" "1168.5" "1153.5" "1198.9" "1296.3" "1208.5" "" "" "" "" "" "" "" "" "" "" "1132.7" "1019.4" "1102.4" "861.8" "956.7" "1116.4" "1054.0" "1064.5" "1296.3" "1163.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4996428185622591073" "False" "High" "IsMasterProtein" "Q9NZB2" "Constitutive coactivator of PPAR-gamma-like protein 1 OS=Homo sapiens OX=9606 GN=FAM120A PE=1 SV=2" "0.000" "False" "58.623" "18" "16" "22" "16" "1118" "121.8" "8.88" "77.68" "16" "" "plasma membrane;other membranes;cytosol;nucleus" "" "" "23196" "ENSG00000048828" "FAM120A" "A6NGU0; C4AMC6; hsa:23196; O60649; Q14688; Q4VXF4; Q4VXF5; Q4VXG2; Q86V69; Q96I21; Q9NZB1; Q9NZB2" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.022" "1.043" "0.970" "1.048" "0.999" "0.951" "0.929" "0.982" "1.052" "1470.2" "1503.2" "1532.8" "1426.4" "1541.0" "1468.2" "1398.8" "1365.7" "1443.7" "1546.6" "" "" "" "" "" "" "" "" "" "" "1377.5" "1243.9" "1423.0" "1102.7" "1313.5" "1402.7" "1278.1" "1212.6" "1443.7" "1489.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8760607610450426056" "False" "High" "IsMasterProtein" "P35251" "Replication factor C subunit 1 OS=Homo sapiens OX=9606 GN=RFC1 PE=1 SV=4" "0.000" "False" "58.501" "18" "19" "21" "19" "1148" "128.2" "9.36" "65.84" "19" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00004, Pf00533, Pf08519" "5981" "ENSG00000035928" "RFC1" "A8K6E7; hsa:5981; P35251; Q5XKF5; Q6PKU0; Q86V41; Q86V46" "miRNA regulation of DNA damage response; DNA replication; Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair; DNA damage response" "PCNA-Dependent Long Patch Base Excision Repair; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "22" "0" "0.990" "1.037" "0.961" "1.018" "1.014" "0.963" "0.989" "0.987" "1.015" "3090.8" "3061.2" "3204.9" "2969.1" "3147.2" "3132.6" "2977.1" "3055.8" "3049.7" "3137.7" "" "" "" "" "" "" "" "" "" "" "2896.1" "2533.1" "2975.3" "2295.3" "2682.6" "2992.9" "2720.3" "2713.3" "3049.7" "3021.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4363739394428502664" "False" "High" "IsMasterProtein" "O75330" "Hyaluronan mediated motility receptor OS=Homo sapiens OX=9606 GN=HMMR PE=1 SV=2" "0.000" "False" "58.438" "24" "20" "22" "20" "724" "84.0" "5.83" "69.74" "20" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf15905, Pf15908" "3161" "ENSG00000072571" "HMMR" "A8K3G2; B4E114; D3DQK9; D3DQL0; E9PCS0; hsa:3161; O75330; Q32N02; Q92767" "" "AURKA Activation by TPX2; Hyaluronan uptake and degradation" "2" "0" "1.030" "1.000" "1.002" "1.040" "1.044" "0.943" "0.927" "0.917" "1.023" "2310.2" "2380.6" "2311.3" "2315.2" "2403.3" "2411.1" "2178.7" "2141.4" "2119.6" "2363.3" "" "" "" "" "" "" "" "" "" "" "2164.7" "1969.9" "2145.8" "1789.7" "2048.5" "2303.6" "1990.8" "1901.4" "2119.6" "2275.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7273803465605434037" "False" "High" "IsMasterProtein" "P05455" "Lupus La protein OS=Homo sapiens OX=9606 GN=SSB PE=1 SV=2" "0.000" "False" "58.327" "45" "18" "37" "18" "408" "46.8" "7.12" "104.14" "18" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf05383, Pf08777" "6741" "ENSG00000138385" "SSB" "hsa:6741; P05455; Q15367; Q53XJ4" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination" "2" "0" "0.981" "0.974" "0.990" "0.931" "0.931" "0.952" "0.970" "0.990" "0.954" "3930.6" "3854.7" "3829.5" "3892.7" "3658.2" "3659.3" "3741.4" "3812.9" "3892.4" "3750.3" "" "" "" "" "" "" "" "" "" "" "3683.0" "3189.7" "3555.2" "3009.3" "3118.1" "3496.1" "3418.6" "3385.5" "3892.4" "3611.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6978617919950458725" "False" "High" "IsMasterProtein" "O43592" "Exportin-T OS=Homo sapiens OX=9606 GN=XPOT PE=1 SV=2" "0.000" "False" "58.298" "19" "18" "28" "18" "962" "109.9" "5.39" "78.93" "18" "transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf19282" "11260" "ENSG00000184575" "XPOT" "A6NLH1; hsa:11260; O43592; O43784; Q8WUG2; Q9BVS7" "" "tRNA processing in the nucleus" "1" "0" "0.969" "1.009" "1.037" "0.997" "0.981" "1.034" "0.990" "1.071" "1.042" "1802.9" "1747.3" "1819.5" "1869.9" "1796.9" "1768.6" "1863.8" "1784.8" "1931.5" "1878.5" "" "" "" "" "" "" "" "" "" "" "1689.3" "1445.9" "1689.2" "1445.5" "1531.6" "1689.8" "1703.0" "1584.7" "1931.5" "1808.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2770447616449315305" "False" "High" "IsMasterProtein" "Q9Y678" "Coatomer subunit gamma-1 OS=Homo sapiens OX=9606 GN=COPG1 PE=1 SV=1" "0.000" "False" "58.157" "22" "18" "32" "17" "874" "97.7" "5.47" "97.51" "18" "transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf01602, Pf08752, Pf16381" "22820" "ENSG00000181789" "COPG1" "A8K6M8; B3KMF6; hsa:22820; Q54AC4; Q9Y678" "VEGFA-VEGFR2 signaling" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "3" "1" "0.972" "1.018" "1.018" "0.985" "0.985" "0.971" "0.961" "0.978" "0.976" "3431.5" "3335.8" "3495.0" "3494.7" "3378.9" "3380.8" "3332.6" "3298.5" "3355.6" "3348.5" "" "" "" "" "" "" "" "" "" "" "3215.4" "2760.3" "3244.7" "2701.6" "2880.1" "3230.0" "3045.1" "2928.7" "3355.6" "3224.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2399497510241032173" "False" "High" "IsMasterProtein" "P25705" "ATP synthase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1A PE=1 SV=1" "0.000" "False" "58.087" "35" "18" "30" "18" "553" "59.7" "9.13" "97.34" "18" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00006, Pf00306, Pf02874" "498" "ENSG00000152234" "ATP5F1A" "A8K092; B4DY56; hsa:498; K7ENP3; P25705; Q53XX6; Q8IXV2; Q96FB4; Q96HW2; Q96IR6; Q9BTV8" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Mitochondrial protein import; Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "7" "0" "1.044" "1.035" "1.015" "1.042" "1.031" "1.108" "1.063" "1.044" "1.015" "3123.7" "3259.8" "3232.6" "3171.2" "3253.8" "3219.4" "3462.0" "3320.3" "3262.2" "3171.6" "" "" "" "" "" "" "" "" "" "" "2926.9" "2697.5" "3001.1" "2451.5" "2773.5" "3075.8" "3163.3" "2948.1" "3262.2" "3053.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6929162783006905550" "False" "High" "IsMasterProtein" "P20042" "Eukaryotic translation initiation factor 2 subunit 2 OS=Homo sapiens OX=9606 GN=EIF2S2 PE=1 SV=2" "0.000" "False" "58.056" "41" "13" "26" "13" "333" "38.4" "5.80" "83.43" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01873" "8894" "ENSG00000125977" "EIF2S2" "hsa:8894; P20042; Q9BVU0; Q9UJE4" "Translation factors; Brain-derived neurotrophic factor (BDNF) signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Primary ovarian insufficiency" "ABC-family proteins mediated transport; PKR-mediated signaling; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "16" "0" "0.951" "0.998" "0.966" "1.013" "0.979" "0.953" "0.960" "1.015" "1.010" "3138.3" "2984.3" "3131.9" "3031.5" "3179.8" "3073.0" "2991.0" "3012.2" "3185.6" "3169.7" "" "" "" "" "" "" "" "" "" "" "2940.5" "2469.5" "2907.5" "2343.5" "2710.4" "2936.0" "2732.9" "2674.6" "3185.6" "3051.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7200124319077870265" "False" "High" "IsMasterProtein" "P35998" "26S proteasome regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMC2 PE=1 SV=3" "0.000" "False" "57.694" "39" "16" "29" "16" "433" "48.6" "5.95" "90.49" "16" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf17862, Pf21236" "5701" "ENSG00000161057" "PSMC2" "A4D0Q1; B7Z5E2; hsa:5701; P35998; Q3LIA5; Q9UDI3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Separation of Sister Chromatids; Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Downstream TCR signaling; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "0.957" "0.946" "0.997" "0.965" "0.954" "0.931" "0.966" "0.919" "0.937" "2968.0" "2840.8" "2808.9" "2957.9" "2863.4" "2832.6" "2761.9" "2866.3" "2726.5" "2779.7" "" "" "" "" "" "" "" "" "" "" "2781.0" "2350.7" "2607.7" "2286.6" "2440.7" "2706.3" "2523.6" "2545.0" "2726.5" "2676.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9142633453092605073" "False" "High" "IsMasterProtein" "Cont_P63103" "14-3-3 protein zeta/delta OS=Bos taurus OX=9913 GN=YWHAZ PE=1 SV=1" "0.000" "True" "57.564" "62" "14" "70" "9" "245" "27.7" "4.79" "192.29" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00244" "100030704; 100056060; 100127113; 100173609; 100411134; 100484483; 100596460; 100672224; 100727182; 100913480; 100977477; 101012101; 101021050; 101151099; 101331119; 101351914; 101384625; 101687663; 101721954; 101968271; 102019696; 102115184; 102175223; 102283808; 102742022; 102765675; 103004481; 103085559; 103121925; 103191924; 103261347; 103732836; 105005492; 105302907; 105476048; 105504209; 105542098; 105586543; 105719669; 105869900; 106847839; 107142838; 107512228; 109277999; 109382800; 109568481; 109697135; 287022; 472830; 475864; 709723; 7534; 780440" "ENSAMEG00000000328; ENSANAG00000027160; ENSBGRG00000009704; ENSBIXG00000019500; ENSBIXG00005001276; ENSBMSG00010017904; ENSBTAG00000000236; ENSCAFG00000000580; ENSCAFG00845028920; ENSCANG00000043345; ENSCATG00000024186; ENSCCAG00000037757; ENSCCNG00000015730; ENSCHIG00000020223; ENSCJAG00000015844; ENSCLAG00000004303; ENSCPOG00000040522; ENSCWAG00000015721; ENSDLEG00000002530; ENSEASG00005002806; ENSECAG00000021882; ENSFCAG00000037073; ENSG00000164924; ENSGGOG00000022133; ENSHGLG00100048437; ENSLAFG00000004944; ENSMFAG00000001740; ENSMICG00000034946; ENSMLEG00000033187; ENSMMMG00000016188; ENSMMNG00015011551; ENSMMSG00000002669; ENSMMUG00000006489; ENSMNEG00000041365; ENSMODG00000006158; ENSMPUG00000015158; ENSNGAG00000006289; ENSNLEG00000030006; ENSPANG00000010317; ENSPANG00000042694; ENSPEMG00000021714; ENSPPAG00000038734; ENSPPYG00000018791; ENSPSMG00000012736; ENSPSNG00000018640; ENSPTEG00000005862; ENSPTIG00000021410; ENSPTRG00000048115; ENSRFEG00010019368; ENSSBOG00000021820; ENSSDAG00000019504; ENSSHAG00000012671; ENSSSCG00000006062; ENSSSCG00015031811; ENSSSCG00025071491; ENSSSCG00035013965; ENSSSCG00045030109; ENSSSCG00050034502; ENSSSCG00055001784; ENSSSCG00060049326; ENSSSCG00070011887; ENSSSUG00005013206; ENSSTOG00000023864; ENSSVLG00005003330; ENSTSYG00000026493; ENSTTRG00000015906; ENSUAMG00000024432; ENSUMAG00000017568; ENSVURG00010007014; ENSVVUG00000013173" "LOC101351914; LOC111146608; Ywhaz; YWHAZ" "A0A096NQ71; A0A097C2Z1; A0A1D5QAJ7; A0A1S3ABR1; A0A1U7TL92; A0A250XWX3; A0A286XIL7; A0A2I2UD77; A0A2I3GBB0; A0A2J8PMJ1; A0A2J8UFH0; A0A2K5DCH7; A0A2K5KE38; A0A2K5L5H7; A0A2K5SHP3; A0A2K5TVK5; A0A2K5YR93; A0A2K6DL02; A0A2K6SRG4; A0A2R9BQD0; A0A2U3W322; A0A2U3YQG6; A0A2U4AHZ7; A0A2Y9GYG0; A0A2Y9JAB1; A0A2Y9PAR8; A0A2Y9QK13; A0A340XXA5; A0A344MNR9; A0A383ZE89; A0A384BYY2; A0A3Q7NYD6; A0A3Q7S418; A0A452SHE3; A0A480PLY3; A0A4W2CSD8; A0A4X1TV95; A0A4X2KB08; A0A518J2H6; A0A5E4AK25; A0A671FTZ7; A0A673UG86; A0A6B0SHT8; A0A6D2XVW1; A0A6J0W154; A0A6J1ZUX6; A0A6J2B9D9; A0A6J2NBP1; A0A6J3FPA9; A0A6P3J5F7; A0A6P3R2S0; A0A6P5CUI6; A0A6P5ISH5; A0A6P6HS74; A0A7J7TL19; A0A7J7VNU9; A0A7J8C4Y7; A0A7J8DUV8; A0A7N4P7P6; A0A7N5KS25; A0A8B6ZD59; A0A8B7G6A9; A0A8B7RAL2; A0A8B8VLP3; A0A8B9X1D7; A0A8C2UZS6; A0A8C3WSB1; A0A8C4KZ72; A0A8C5ZR25; A0A8C6BH51; A0A8C6CXQ8; A0A8C6QKN2; A0A8C8U9V5; A0A8C8ZIR5; A0A8C9E7Q2; A0A8C9GP54; A0A8C9KQT4; A0A8C9Q7D7; A0A8D2CLR5; A0A8I3Q1P7; A0A8J8XBY4; A0A8J8Y9Q2; A0A8P0S6K0; A0A9V1GJ83; A0A9X9LZ30; A8K1N0; aju:106980045; aml:100484483; B7Z465; bacu:103004481; bbis:105005492; biu:109568481; bom:102283808; bta:287022; cang:105504209; caty:105586543; ccan:109697135; cfa:475864; chx:102175223; cjc:100411134; cpoc:100727182; csyr:103261347; D0PNI1; dle:111180376; elk:111146608; F6XEB4; F7BS95; F7EFF6; F7G9D2; F7HBD4; fca:100127113; G3RS45; G3SV87; G5AP01; G7MZV8; G7PCF6; ggo:101151099; hai:109382800; hgl:101721954; hsa:7534; I3N206; K7DDM2; L5M3G8; lav:100672224; lve:103085559; lww:102742022; M3WVC7; M3YUN9; mcc:709723; mcf:102115184; mdo:100030704; mleu:105542098; mmur:105869900; mni:105476048; mpuf:101687663; myd:102765675; ngi:103732836; nle:100596460; nsu:110579154; oro:101384625; P29213; P29312; P63103; P63104; panu:101012101; panu:101021050; pcoo:112859599; pcw:110196285; pdic:114514896; pon:100173609; pps:100977477; ptg:102966103; ptr:472830; pvp:105302907; Q32P43; Q3ZCF9; Q5R651; Q5XJ08; Q6GPI2; Q6IN74; Q6NUR9; Q6P3U9; Q86V33; ray:107512228; sbq:101047958; shr:100913480; tmu:101351914; U3E3R3; umr:103661509; vvp:112916971; zca:113910054" "Calcium regulation in cardiac cell; Cell cycle; Cell cycle; Prolactin signaling pathway; Pathogenic Escherichia coli infection; Myometrial relaxation and contraction pathways; SIDS susceptibility pathways; Pathogenic Escherichia coli infection; Myometrial relaxation and contraction pathways; Hepatitis B infection; GDNF signaling; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways; Calcium regulation in cardiac cells" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; Deactivation of the beta-catenin transactivating complex; TP53 Regulates Metabolic Genes; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria ; TP53 Regulates Metabolic Genes; Interleukin-3, Interleukin-5 and GM-CSF signaling; Activation of BAD and translocation to mitochondria ; Rap1 signalling; RHO GTPases activate PKNs; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Regulation of localization of FOXO transcription factors; Deactivation of the beta-catenin transactivating complex; KSRP (KHSRP) binds and destabilizes mRNA; GP1b-IX-V activation signalling; NOTCH4 Activation and Transmission of Signal to the Nucleus; Negative regulation of NOTCH4 signaling; Interleukin-3, Interleukin-5 and GM-CSF signaling; NOTCH4 Activation and Transmission of Signal to the Nucleus; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Rap1 signalling; KSRP (KHSRP) binds and destabilizes mRNA; GP1b-IX-V activation signalling" "40" "0" "1.049" "1.016" "0.897" "1.034" "0.991" "0.910" "1.031" "1.118" "1.021" "1745.8" "1832.1" "1774.5" "1565.9" "1805.8" "1730.9" "1588.1" "1800.4" "1952.2" "1781.8" "" "" "" "" "" "" "" "" "" "" "1635.8" "1516.0" "1647.4" "1210.5" "1539.2" "1653.7" "1451.1" "1598.6" "1952.2" "1715.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7216673517695953879" "False" "High" "IsMasterProtein" "Q8TDZ2" "[F-actin]-monooxygenase MICAL1 OS=Homo sapiens OX=9606 GN=MICAL1 PE=1 SV=2" "0.000" "False" "57.432" "18" "18" "24" "18" "1067" "117.8" "6.40" "74.98" "18" "cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00412, Pf01494, Pf12130" "64780" "ENSG00000135596" "MICAL1" "B7Z3R5; E1P5F0; Q7Z633; Q8IVS9; Q8TDZ2; Q96G47; Q9H6X6; Q9H7I0; Q9HAA1; Q9UFF7" "" "Factors involved in megakaryocyte development and platelet production" "1" "0" "0.967" "0.966" "0.943" "0.972" "0.978" "0.930" "0.852" "0.857" "0.928" "2655.2" "2566.9" "2565.3" "2502.8" "2581.8" "2597.8" "2469.5" "2262.9" "2275.0" "2462.8" "" "" "" "" "" "" "" "" "" "" "2487.9" "2124.1" "2381.5" "1934.8" "2200.7" "2482.0" "2256.5" "2009.3" "2275.0" "2371.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6804108956499343623" "False" "High" "IsMasterProtein" "Q96G03" "Phosphopentomutase OS=Homo sapiens OX=9606 GN=PGM2 PE=1 SV=4" "0.000" "False" "57.427" "27" "16" "23" "15" "612" "68.2" "6.73" "75.49" "16" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf02878, Pf02879, Pf02880" "55276" "ENSG00000169299" "PGM2" "B4E0G8; hsa:55276; Q53FP5; Q5QTR0; Q96G03; Q9H0P9; Q9NV22" "Clear cell renal cell carcinoma pathways; Glucuronidation" "Neutrophil degranulation; Pentose phosphate pathway" "4" "1" "0.974" "0.999" "0.995" "0.939" "0.968" "0.922" "0.959" "0.960" "0.946" "3839.6" "3741.3" "3835.2" "3821.9" "3605.2" "3716.4" "3539.1" "3680.5" "3685.9" "3631.4" "" "" "" "" "" "" "" "" "" "" "3597.7" "3095.9" "3560.5" "2954.5" "3072.9" "3550.7" "3233.8" "3267.9" "3685.9" "3496.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1964707792463719030" "False" "High" "IsMasterProtein" "O43776" "Asparagine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=NARS1 PE=1 SV=1" "0.000" "False" "57.189" "33" "19" "34" "19" "548" "62.9" "6.25" "107.13" "19" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00152, Pf01336, Pf20917" "4677" "ENSG00000134440" "NARS1" "B4DG16; hsa:4677; O43776; Q53GU6" "Photodynamic therapy-induced unfolded protein response" "Cytosolic tRNA aminoacylation" "2" "0" "1.017" "0.958" "0.917" "0.934" "0.920" "0.917" "0.919" "0.947" "0.922" "3196.1" "3250.6" "3060.9" "2929.3" "2986.0" "2939.9" "2930.2" "2936.1" "3025.2" "2947.9" "" "" "" "" "" "" "" "" "" "" "2994.7" "2689.9" "2841.7" "2264.5" "2545.2" "2808.8" "2677.4" "2607.0" "3025.2" "2838.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5545156882891984968" "False" "High" "IsMasterProtein" "P07954" "Fumarate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=FH PE=1 SV=3" "0.000" "False" "57.164" "35" "15" "27" "15" "510" "54.6" "8.76" "83.54" "15" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00206, Pf10415" "2271" "ENSG00000091483" "FH" "B1ANK7; hsa:2271; P07954" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Krebs cycle disorders; Type 2 papillary renal cell carcinoma; Metabolic reprogramming in colon cancer; TCA cycle in senescence; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "9" "0" "0.965" "1.005" "0.929" "0.959" "0.967" "0.943" "0.985" "0.965" "0.940" "3527.7" "3402.5" "3544.5" "3278.7" "3383.8" "3412.2" "3326.4" "3474.4" "3403.0" "3314.5" "" "" "" "" "" "" "" "" "" "" "3305.4" "2815.5" "3290.7" "2534.6" "2884.3" "3260.1" "3039.4" "3084.9" "3403.0" "3191.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2006906941817689569" "False" "High" "IsMasterProtein" "Q9Y520" "Protein PRRC2C OS=Homo sapiens OX=9606 GN=PRRC2C PE=1 SV=4" "0.000" "False" "56.980" "6" "18" "26" "16" "2896" "316.7" "9.13" "81.29" "18" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "" "Pf07001" "23215" "ENSG00000117523" "PRRC2C" "hsa:23215; Q05DM8; Q49A39; Q6PD54; Q9H2N2; Q9HA05; Q9NSM8; Q9NXL3; Q9UF29; Q9UPQ6; Q9Y520" "VEGFA-VEGFR2 signaling" "" "1" "2" "1.021" "1.011" "1.034" "1.055" "1.027" "1.226" "1.226" "1.193" "1.102" "2983.5" "3046.5" "3017.5" "3084.1" "3147.8" "3064.8" "3657.7" "3657.3" "3560.5" "3287.8" "" "" "" "" "" "" "" "" "" "" "2795.5" "2521.0" "2801.3" "2384.2" "2683.1" "2928.2" "3342.2" "3247.3" "3560.5" "3165.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4594033010686828793" "False" "High" "IsMasterProtein" "P48637" "Glutathione synthetase OS=Homo sapiens OX=9606 GN=GSS PE=1 SV=1" "0.000" "False" "56.672" "40" "17" "25" "17" "474" "52.4" "5.92" "81.93" "17" "other metabolic processes;stress response;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf03199, Pf03917" "2937" "ENSG00000100983" "GSS" "B2R697; B6F210; E1P5P9; hsa:2937; P48637; Q4TTD9" "Glutathione metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways; Ferroptosis; Metapathway biotransformation Phase I and II" "Glutathione synthesis and recycling; Defective GSS causes GSS deficiency" "8" "0" "0.967" "0.991" "0.985" "0.986" "0.977" "0.959" "0.989" "0.972" "0.990" "2242.4" "2169.0" "2221.4" "2208.7" "2210.4" "2190.1" "2150.3" "2216.7" "2178.8" "2218.9" "" "" "" "" "" "" "" "" "" "" "2101.1" "1794.8" "2062.3" "1707.4" "1884.1" "2092.4" "1964.8" "1968.2" "2178.8" "2136.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4780754661784181438" "False" "High" "IsMasterProtein" "O95373" "Importin-7 OS=Homo sapiens OX=9606 GN=IPO7 PE=1 SV=1" "0.000" "False" "56.529" "21" "17" "25" "17" "1038" "119.4" "4.82" "79.60" "17" "stress response;transport;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf03810, Pf08506" "10527" "ENSG00000205339" "IPO7" "A6NNM5; B2R786; hsa:10527; O95373; Q1RMF7; Q9H177; Q9NTE3" "" "" "0" "0" "0.917" "0.980" "0.956" "0.939" "0.937" "0.916" "0.918" "0.936" "0.954" "4096.4" "3757.8" "4012.5" "3914.7" "3845.5" "3838.8" "3751.6" "3759.1" "3834.3" "3909.1" "" "" "" "" "" "" "" "" "" "" "3838.3" "3109.6" "3725.1" "3026.2" "3277.8" "3667.6" "3428.0" "3337.7" "3834.3" "3763.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5219195248541824635" "False" "High" "IsMasterProtein" "Q92609" "TBC1 domain family member 5 OS=Homo sapiens OX=9606 GN=TBC1D5 PE=1 SV=1" "0.000" "False" "56.440" "25" "17" "28" "17" "795" "88.9" "6.54" "92.01" "17" "other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00566" "9779" "ENSG00000131374" "TBC1D5" "A6NP25; C9JP52; hsa:9779; Q92609" "" "" "0" "0" "1.151" "1.007" "1.049" "1.083" "1.084" "0.993" "0.979" "1.012" "1.037" "1480.8" "1704.2" "1491.2" "1552.9" "1603.4" "1604.7" "1470.8" "1449.5" "1498.7" "1535.8" "" "" "" "" "" "" "" "" "" "" "1387.5" "1410.2" "1384.4" "1200.4" "1366.7" "1533.1" "1343.9" "1287.0" "1498.7" "1478.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1422761924457517511" "False" "High" "IsMasterProtein" "A3KN83" "Protein strawberry notch homolog 1 OS=Homo sapiens OX=9606 GN=SBNO1 PE=1 SV=1" "0.000" "False" "56.368" "16" "18" "22" "18" "1393" "154.2" "7.88" "66.26" "18" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13871, Pf13872" "55206" "ENSG00000139697" "SBNO1" "A3KN83; Q05C06; Q3ZTS3; Q9H3T8; Q9NVB2" "" "" "0" "0" "0.983" "0.992" "1.055" "1.036" "1.052" "1.018" "1.044" "1.023" "1.054" "1270.3" "1248.2" "1260.6" "1340.0" "1315.9" "1336.9" "1292.7" "1326.6" "1299.4" "1339.3" "" "" "" "" "" "" "" "" "" "" "1190.2" "1032.9" "1170.3" "1035.9" "1121.6" "1277.3" "1181.2" "1177.9" "1299.4" "1289.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4128551820349889228" "False" "High" "IsMasterProtein" "P51531" "Probable global transcription activator SNF2L2 OS=Homo sapiens OX=9606 GN=SMARCA2 PE=1 SV=2" "0.000" "False" "56.310" "12" "19" "24" "8" "1590" "181.2" "7.20" "69.23" "19" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf14619" "6595" "ENSG00000080503" "SMARCA2" "B1ALG3; B1ALG4; D3DRH4; D3DRH5; hsa:6595; P51531" "Retinoblastoma gene in cancer; Pathways affected in adenoid cystic carcinoma; VEGFA-VEGFR2 signaling; Rett syndrome; Thermogenesis; Kleefstra syndrome" "RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "8" "0" "0.994" "0.976" "0.944" "0.946" "0.960" "0.892" "0.909" "0.906" "0.960" "2036.8" "2024.5" "1987.2" "1923.7" "1926.4" "1955.1" "1816.0" "1850.7" "1845.9" "1955.9" "" "" "" "" "" "" "" "" "" "" "1908.5" "1675.2" "1844.9" "1487.1" "1642.0" "1867.9" "1659.3" "1643.2" "1845.9" "1883.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6066576864868279087" "False" "High" "IsMasterProtein" "Q9Y263" "Phospholipase A-2-activating protein OS=Homo sapiens OX=9606 GN=PLAA PE=1 SV=2" "0.000" "False" "56.291" "24" "16" "26" "16" "795" "87.1" "6.37" "76.13" "16" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf08324, Pf09070" "9373" "ENSG00000137055" "PLAA" "hsa:9373; Q53EU5; Q5VY33; Q9NUL8; Q9NVE9; Q9UF53; Q9Y263; Q9Y5L1" "" "" "0" "0" "0.999" "1.023" "1.029" "1.026" "1.028" "1.017" "0.998" "1.033" "1.033" "2237.3" "2235.1" "2287.8" "2301.8" "2295.7" "2300.8" "2275.4" "2232.3" "2311.8" "2312.1" "" "" "" "" "" "" "" "" "" "" "2096.3" "1849.5" "2124.0" "1779.4" "1956.8" "2198.2" "2079.1" "1982.0" "2311.8" "2226.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4232598259152992278" "False" "High" "IsMasterProtein" "Q86Y56" "Dynein axonemal assembly factor 5 OS=Homo sapiens OX=9606 GN=DNAAF5 PE=1 SV=4" "0.000" "False" "56.275" "23" "17" "27" "17" "855" "93.5" "6.42" "86.32" "17" "cell organization and biogenesis;other biological processes" "other cell component" "other molecular function" "Pf02985" "54919" "ENSG00000164818" "DNAAF5" "hsa:54919; Q69YL1; Q86Y56; Q96FI9; Q9NX75" "Ciliopathies" "" "1" "0" "0.978" "1.006" "1.067" "1.004" "0.994" "1.008" "0.972" "0.974" "1.031" "2140.2" "2093.2" "2152.2" "2284.0" "2148.2" "2128.2" "2157.2" "2079.6" "2083.8" "2205.6" "" "" "" "" "" "" "" "" "" "" "2005.4" "1732.1" "1998.0" "1765.6" "1831.1" "2033.3" "1971.1" "1846.4" "2083.8" "2123.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1176127761844367310" "False" "High" "IsMasterProtein" "Q9H2G2" "STE20-like serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=SLK PE=1 SV=1" "0.000" "False" "56.152" "16" "19" "22" "18" "1235" "142.6" "5.15" "77.87" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12474" "9748" "ENSG00000065613" "SLK" "D3DRA0; D3DRA1; hsa:9748; O00211; Q6P1Z4; Q86WU7; Q86WW1; Q92603; Q9H2G2; Q9NQL0; Q9NQL1" "TAR syndrome" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle" "4" "0" "1.027" "0.994" "0.993" "1.034" "1.005" "0.968" "1.004" "0.992" "1.010" "2688.7" "2760.9" "2671.7" "2670.2" "2778.9" "2701.0" "2601.4" "2699.9" "2667.8" "2716.3" "" "" "" "" "" "" "" "" "" "" "2519.3" "2284.6" "2480.3" "2064.2" "2368.6" "2580.5" "2377.0" "2397.3" "2667.8" "2615.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2986049448252169894" "False" "High" "IsMasterProtein" "Q8N3U4" "Cohesin subunit SA-2 OS=Homo sapiens OX=9606 GN=STAG2 PE=1 SV=3" "0.000" "False" "56.077" "16" "20" "28" "14" "1231" "141.2" "5.43" "87.58" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08514, Pf21581" "10735" "ENSG00000101972" "STAG2" "B1AMT5; D3DTF5; hsa:10735; O00540; Q5JTI6; Q68DE9; Q8N3U4; Q9H1N8" "Cell cycle; Cohesin complex - Cornelia de Lange syndrome" "SUMOylation of DNA damage response and repair proteins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "9" "0" "0.943" "1.036" "0.921" "0.898" "0.939" "0.937" "0.924" "0.937" "0.930" "2994.3" "2823.7" "3100.7" "2757.0" "2689.0" "2811.0" "2806.5" "2767.3" "2804.3" "2785.5" "" "" "" "" "" "" "" "" "" "" "2805.6" "2336.6" "2878.6" "2131.3" "2292.0" "2685.6" "2564.4" "2457.0" "2804.3" "2682.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4058456233631452436" "False" "High" "IsMasterProtein" "Q06830" "Peroxiredoxin-1 OS=Homo sapiens OX=9606 GN=PRDX1 PE=1 SV=1" "0.000" "False" "56.042" "51" "11" "60" "7" "199" "22.1" "8.13" "188.08" "11" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00578, Pf10417" "5052" "ENSG00000117450" "PRDX1" "B5BU26; D3DPZ8; hsa:5052; P35703; Q06830; Q2V576; Q5T154; Q5T155" "Androgen receptor signaling pathway; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway; HDAC6 interactions in the central nervous system" "Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes; NFE2L2 regulating anti-oxidant/detoxification enzymes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "9" "4" "1.001" "0.972" "0.970" "0.948" "0.969" "0.943" "0.967" "0.991" "0.953" "6400.6" "6408.1" "6224.3" "6208.5" "6068.1" "6200.0" "6037.5" "6189.2" "6342.7" "6097.0" "" "" "" "" "" "" "" "" "" "" "5997.3" "5302.6" "5778.4" "4799.5" "5172.3" "5923.5" "5516.7" "5495.4" "6342.7" "5870.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7815504497160521648" "False" "High" "IsMasterProtein" "Q01826" "DNA-binding protein SATB1 OS=Homo sapiens OX=9606 GN=SATB1 PE=1 SV=1" "0.000" "False" "55.935" "23" "17" "30" "17" "763" "85.9" "6.54" "105.75" "17" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf02376, Pf16534, Pf16557" "6304" "ENSG00000182568" "SATB1" "B3KXF1; C9JTR6; hsa:6304; Q01826; Q59EQ0" "Vitamin D receptor pathway" "SUMOylation of chromatin organization proteins; Apoptotic cleavage of cellular proteins" "3" "0" "0.936" "1.004" "0.936" "0.975" "0.964" "0.951" "0.994" "0.938" "0.968" "3668.7" "3435.7" "3682.4" "3433.1" "3576.2" "3538.4" "3489.0" "3646.7" "3442.3" "3549.8" "" "" "" "" "" "" "" "" "" "" "3437.6" "2843.0" "3418.7" "2653.9" "3048.3" "3380.7" "3188.0" "3237.9" "3442.3" "3417.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7129667850847229200" "False" "High" "IsMasterProtein" "P52209" "6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens OX=9606 GN=PGD PE=1 SV=3" "0.000" "False" "55.905" "30" "14" "32" "14" "483" "53.1" "7.23" "100.36" "14" "other metabolic processes" "cytosol" "other molecular function" "Pf00393, Pf03446" "5226" "ENSG00000142657" "PGD" "A8K2Y9; B4DQJ8; hsa:5226; P52209; Q9BWD8" "Pentose phosphate metabolism; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer" "NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway" "7" "0" "0.893" "0.957" "0.927" "0.905" "0.914" "0.888" "0.932" "0.898" "0.892" "3759.3" "3355.8" "3596.5" "3485.7" "3400.4" "3437.4" "3338.3" "3502.3" "3376.2" "3352.7" "" "" "" "" "" "" "" "" "" "" "3522.4" "2776.8" "3338.9" "2694.6" "2898.4" "3284.1" "3050.3" "3109.7" "3376.2" "3228.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1037069693652576559" "False" "High" "IsMasterProtein" "P31943" "Heterogeneous nuclear ribonucleoprotein H OS=Homo sapiens OX=9606 GN=HNRNPH1 PE=1 SV=4" "0.000" "False" "55.777" "42" "14" "38" "6" "449" "49.2" "6.30" "138.08" "14" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08080" "3187" "ENSG00000169045; ENSG00000284254" "HNRNPH1" "B3KW86; D3DWQ2; P31943; Q6IBM4" "MECP2 and associated Rett syndrome; mRNA processing; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "6" "7" "0.992" "1.024" "1.046" "1.041" "1.048" "0.957" "0.983" "1.031" "1.038" "2169.1" "2152.5" "2221.6" "2269.6" "2257.1" "2272.4" "2075.2" "2131.6" "2235.9" "2251.6" "" "" "" "" "" "" "" "" "" "" "2032.4" "1781.2" "2062.5" "1754.5" "1923.9" "2171.0" "1896.2" "1892.6" "2235.9" "2168.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6653265809957974706" "False" "High" "IsMasterProtein" "Q14157" "Ubiquitin-associated protein 2-like OS=Homo sapiens OX=9606 GN=UBAP2L PE=1 SV=2" "0.000" "False" "55.739" "22" "17" "24" "17" "1087" "114.5" "7.11" "83.59" "17" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf12478" "9898" "ENSG00000143569" "UBAP2L" "B4E0U8; hsa:9898; Q14157; Q5VU75; Q5VU76; Q9BTU3; Q9UGL2; Q9UGL3; Q9UGL4; Q9UGL5" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.053" "1.030" "0.942" "1.009" "0.989" "0.983" "0.993" "0.975" "0.998" "3343.2" "3522.0" "3442.0" "3150.3" "3372.7" "3305.4" "3287.4" "3320.2" "3258.8" "3336.3" "" "" "" "" "" "" "" "" "" "" "3132.6" "2914.4" "3195.5" "2435.4" "2874.8" "3158.0" "3003.8" "2948.0" "3258.8" "3212.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1718244645714628913" "False" "High" "IsMasterProtein" "Q9UIA9" "Exportin-7 OS=Homo sapiens OX=9606 GN=XPO7 PE=1 SV=3" "0.000" "False" "55.671" "18" "19" "23" "19" "1087" "123.8" "6.32" "75.00" "19" "transport" "nucleus;other cell component" "other molecular function" "Pf03810" "23039" "ENSG00000130227" "XPO7" "hsa:23039; O94846; Q6PJK9; Q8NEK7; Q9UIA9" "" "" "0" "0" "0.965" "0.901" "1.057" "0.949" "0.915" "1.227" "0.933" "0.907" "0.961" "3844.0" "3707.8" "3462.4" "4064.3" "3648.3" "3517.5" "4714.9" "3588.1" "3485.6" "3693.9" "" "" "" "" "" "" "" "" "" "" "3601.8" "3068.2" "3214.4" "3141.9" "3109.7" "3360.7" "4308.2" "3185.9" "3485.6" "3556.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1669243048092869257" "False" "High" "IsMasterProtein" "Q8WU90" "Zinc finger CCCH domain-containing protein 15 OS=Homo sapiens OX=9606 GN=ZC3H15 PE=1 SV=1" "0.000" "False" "55.605" "34" "15" "26" "15" "426" "48.6" "5.31" "87.87" "15" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00642, Pf16543" "55854" "ENSG00000065548" "ZC3H15" "B4DMW2; D3DPG7; hsa:55854; Q5QTQ4; Q8WU90; Q8WZ06; Q9NUZ3; Q9NZ37; Q9P079" "VEGFA-VEGFR2 signaling" "Protein hydroxylation" "2" "0" "1.086" "0.990" "0.927" "0.965" "0.993" "0.937" "0.952" "0.974" "0.949" "2606.2" "2831.3" "2580.3" "2415.7" "2515.3" "2588.1" "2443.1" "2480.3" "2539.5" "2472.7" "" "" "" "" "" "" "" "" "" "" "2442.0" "2342.9" "2395.5" "1867.5" "2144.0" "2472.6" "2232.4" "2202.3" "2539.5" "2380.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3741204735065001472" "False" "High" "IsMasterProtein" "Q8WXF1" "Paraspeckle component 1 OS=Homo sapiens OX=9606 GN=PSPC1 PE=1 SV=1" "0.000" "False" "55.553" "37" "18" "31" "17" "523" "58.7" "6.67" "96.29" "18" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08075" "55269" "ENSG00000121390" "PSPC1" "hsa:55269; Q5JTQ3; Q8NCZ9; Q8WXE8; Q8WXF1; Q9NV36" "" "" "0" "1" "1.060" "1.061" "1.050" "1.028" "1.043" "1.027" "1.108" "1.073" "1.058" "2508.3" "2658.4" "2662.4" "2632.4" "2578.8" "2616.3" "2575.3" "2779.4" "2690.5" "2653.8" "" "" "" "" "" "" "" "" "" "" "2350.2" "2199.8" "2471.7" "2035.0" "2198.1" "2499.6" "2353.2" "2467.8" "2690.5" "2555.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7644877244443849971" "False" "High" "IsMasterProtein" "Q13177" "Serine/threonine-protein kinase PAK 2 OS=Homo sapiens OX=9606 GN=PAK2 PE=1 SV=3" "0.000" "False" "55.544" "28" "13" "31" "13" "524" "58.0" "5.96" "94.76" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00786" "5062" "ENSG00000180370" "PAK2" "hsa:5062; Q13154; Q13177; Q6ISC3" "Integrin-mediated cell adhesion; Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; MET in type 1 papillary renal cell carcinoma; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 3q29 copy number variation syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway" "FCERI mediated MAPK activation; Regulation of activated PAK-2p34 by proteasome mediated degradation; MAPK6/MAPK4 signaling; RHOU GTPase cycle; RHOV GTPase cycle; Smooth Muscle Contraction; Generation of second messenger molecules; Regulation of PAK-2p34 activity by PS-GAP/RHG10; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Ephrin signaling; Sema3A PAK dependent Axon repulsion; RHO GTPases activate PAKs; VEGFR2 mediated vascular permeability; Activation of RAC1; RHOH GTPase cycle; CD209 (DC-SIGN) signaling; CD28 dependent Vav1 pathway; Nef and signal transduction; Stimulation of the cell death response by PAK-2p34" "45" "0" "1.005" "1.023" "0.926" "0.987" "0.978" "0.905" "0.977" "0.968" "0.963" "3733.8" "3751.4" "3820.9" "3458.2" "3684.8" "3650.8" "3380.8" "3648.4" "3615.7" "3594.3" "" "" "" "" "" "" "" "" "" "" "3498.6" "3104.2" "3547.2" "2673.4" "3140.8" "3488.0" "3089.1" "3239.4" "3615.7" "3460.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951923410761951319" "False" "High" "IsMasterProtein" "Q9UQ80" "Proliferation-associated protein 2G4 OS=Homo sapiens OX=9606 GN=PA2G4 PE=1 SV=3" "0.000" "False" "55.515" "38" "15" "32" "15" "394" "43.8" "6.55" "91.25" "15" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00557" "5036" "ENSG00000170515" "PA2G4" "hsa:5036; O43846; Q9UM59; Q9UQ80" "" "Neutrophil degranulation" "1" "0" "1.001" "1.037" "1.076" "1.096" "1.093" "1.104" "1.167" "1.134" "1.068" "3513.9" "3518.9" "3642.3" "3779.7" "3851.1" "3842.2" "3877.9" "4101.4" "3985.0" "3751.8" "" "" "" "" "" "" "" "" "" "" "3292.5" "2911.9" "3381.4" "2921.8" "3282.6" "3670.9" "3543.4" "3641.6" "3985.0" "3612.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5836622772794954890" "False" "High" "IsMasterProtein" "P06400" "Retinoblastoma-associated protein OS=Homo sapiens OX=9606 GN=RB1 PE=1 SV=2" "0.000" "False" "55.514" "21" "19" "25" "19" "928" "106.1" "7.94" "87.93" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01857, Pf01858, Pf08934, Pf11934" "5925" "ENSG00000139687" "RB1" "A8K5E3; hsa:5925; P06400; P78499; Q5VW46; Q8IZL4" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Adipogenesis; Spinal cord injury; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor pathway; Bladder cancer; Fas ligand pathway and stress induction of heat shock proteins; Photodynamic therapy-induced AP-1 survival signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Effect of progerin on genes involved in progeria; Ciliary landscape; G1 to S cell cycle control; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Overlap between signal transduction pathways contributing to LMNA laminopathies; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; Sphingolipid metabolism in senescence; Prostaglandin and leukotriene metabolism in senescence ; ID signaling pathway; TROP2 regulatory signaling; Prostaglandin and leukotriene metabolism in senescence ; 8q11.23 (RB1CC1) copy number variation; Omega-6-fatty acids in senescence; DNA damage response" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Aberrant regulation of mitotic exit in cancer due to RB1 defects; RUNX2 regulates osteoblast differentiation; Condensation of Prophase Chromosomes; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; Cyclin A:Cdk2-associated events at S phase entry; Formation of Senescence-Associated Heterochromatin Foci (SAHF); Inhibition of replication initiation of damaged DNA by RB1/E2F1; Defective translocation of RB1 mutants to the nucleus; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome; Nuclear events stimulated by ALK signaling in cancer" "51" "0" "0.965" "1.028" "0.968" "0.961" "0.981" "0.909" "0.931" "0.951" "0.952" "4700.2" "4535.2" "4831.0" "4550.4" "4516.5" "4610.1" "4270.3" "4374.8" "4468.8" "4474.4" "" "" "" "" "" "" "" "" "" "" "4404.1" "3752.8" "4485.0" "3517.7" "3849.7" "4404.5" "3901.9" "3884.4" "4468.8" "4308.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8428260618384848940" "False" "High" "IsMasterProtein" "Q15029" "116 kDa U5 small nuclear ribonucleoprotein component OS=Homo sapiens OX=9606 GN=EFTUD2 PE=1 SV=1" "0.000" "False" "55.514" "17" "17" "24" "16" "972" "109.4" "5.00" "74.41" "17" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492, Pf16004" "9343" "ENSG00000108883" "EFTUD2" "B4DK30; B4DMC0; D3DX58; hsa:9343; K7EJ81; Q15029; Q9BUR0" "mRNA processing; Ciliary landscape" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "4" "0" "1.011" "1.060" "1.003" "0.983" "0.989" "0.995" "0.995" "0.983" "0.994" "2622.4" "2652.2" "2779.6" "2629.8" "2578.4" "2592.4" "2609.8" "2608.7" "2577.2" "2606.8" "" "" "" "" "" "" "" "" "" "" "2457.2" "2194.7" "2580.5" "2033.0" "2197.8" "2476.8" "2384.7" "2316.3" "2577.2" "2510.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7550232429458165552" "False" "High" "IsMasterProtein" "Q9NRZ9" "Lymphoid-specific helicase OS=Homo sapiens OX=9606 GN=HELLS PE=1 SV=1" "0.000" "False" "55.458" "18" "16" "21" "16" "838" "97.0" "7.93" "60.89" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00176, Pf00271" "3070" "ENSG00000119969" "HELLS" "B2RB41; hsa:3070; Q3LID1; Q6I7N7; Q76H76; Q76H77; Q76H78; Q76H79; Q76H80; Q76H81; Q7Z397; Q7Z5X2; Q8N6P4; Q9H4P5; Q9NRZ9" "Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer" "" "2" "0" "1.038" "1.049" "1.028" "1.037" "1.070" "0.973" "0.977" "0.972" "1.036" "1710.7" "1776.0" "1795.2" "1759.0" "1773.6" "1830.3" "1664.5" "1671.1" "1662.5" "1772.3" "" "" "" "" "" "" "" "" "" "" "1602.9" "1469.6" "1666.6" "1359.8" "1511.7" "1748.7" "1520.9" "1483.7" "1662.5" "1706.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "144982604897555779" "False" "High" "IsMasterProtein" "P52306" "Rap1 GTPase-GDP dissociation stimulator 1 OS=Homo sapiens OX=9606 GN=RAP1GDS1 PE=1 SV=3" "0.000" "False" "55.352" "29" "16" "32" "15" "607" "66.3" "5.31" "85.14" "16" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;ER/Golgi;nucleus" "enzyme regulator activity" "Pf00514" "5910" "ENSG00000138698" "RAP1GDS1" "E9PH06; G5E9P9; hsa:5910; P52306; Q499L7; Q4KMV2; Q4QQI8; Q9BUW9; Q9BUX6; Q9NYM2; Q9NZA8" "" "RHOT2 GTPase cycle; RHOT1 GTPase cycle" "2" "0" "0.964" "0.985" "0.997" "0.988" "0.960" "0.949" "0.936" "0.918" "0.972" "3223.1" "3107.1" "3176.1" "3214.2" "3183.1" "3093.3" "3058.4" "3016.4" "2959.7" "3132.7" "" "" "" "" "" "" "" "" "" "" "3020.1" "2571.1" "2948.6" "2484.7" "2713.2" "2955.3" "2794.6" "2678.3" "2959.7" "3016.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2123612860387903516" "False" "High" "IsMasterProtein" "P08243" "Asparagine synthetase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=ASNS PE=1 SV=4" "0.000" "False" "55.185" "33" "17" "32" "17" "561" "64.3" "6.86" "83.39" "17" "other metabolic processes;stress response;other biological processes" "cytosol" "other molecular function" "Pf00733, Pf13537" "440" "ENSG00000070669" "ASNS" "A4D1I8; B4DXZ1; B7ZAA9; D6W5R3; E9PCI3; E9PCX6; hsa:440; P08184; P08243; Q15666; Q549T9; Q96HD0" "Photodynamic therapy-induced unfolded protein response; Amino acid metabolism" "Aspartate and asparagine metabolism; Response of EIF2AK1 (HRI) to heme deficiency; ATF4 activates genes in response to endoplasmic reticulum stress; Response of EIF2AK4 (GCN2) to amino acid deficiency" "6" "0" "1.046" "1.042" "1.072" "1.034" "1.039" "1.002" "1.029" "1.048" "1.032" "1612.8" "1686.2" "1681.3" "1728.6" "1668.1" "1675.4" "1616.1" "1659.8" "1689.5" "1663.7" "" "" "" "" "" "" "" "" "" "" "1511.2" "1395.3" "1560.9" "1336.3" "1421.8" "1600.7" "1476.7" "1473.7" "1689.5" "1601.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1828229649447777005" "False" "High" "IsMasterProtein" "P31153" "S-adenosylmethionine synthase isoform type-2 OS=Homo sapiens OX=9606 GN=MAT2A PE=1 SV=1" "0.000" "False" "55.169" "44" "16" "27" "16" "395" "43.6" "6.48" "90.89" "16" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00438, Pf02772, Pf02773" "4144" "ENSG00000168906" "MAT2A" "A8K511; B4DN45; D6W5L1; hsa:4144; P31153; Q53SP5" "Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Methylation pathways" "Methylation" "5" "0" "0.978" "0.958" "0.991" "0.948" "0.985" "0.929" "0.950" "0.970" "0.973" "2539.4" "2484.3" "2432.9" "2517.2" "2407.9" "2501.5" "2360.1" "2413.6" "2462.8" "2469.9" "" "" "" "" "" "" "" "" "" "" "2379.4" "2055.7" "2258.6" "1945.9" "2052.4" "2390.0" "2156.5" "2143.1" "2462.8" "2378.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2706346813500612186" "False" "High" "IsMasterProtein" "Q9C0C9" "(E3-independent) E2 ubiquitin-conjugating enzyme OS=Homo sapiens OX=9606 GN=UBE2O PE=1 SV=3" "0.000" "False" "55.167" "16" "19" "24" "19" "1292" "141.2" "5.12" "70.13" "19" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "63893" "ENSG00000175931" "UBE2O" "A6NDU5; hsa:63893; Q69YP4; Q6PIZ2; Q86UA4; Q8N425; Q8TBN1; Q9BSW1; Q9C0C9; Q9H6E6; Q9H7E4; Q9H9B2" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.957" "1.009" "0.984" "0.989" "0.988" "0.959" "0.948" "0.918" "0.964" "2951.1" "2824.4" "2977.3" "2903.2" "2918.1" "2916.4" "2829.3" "2797.4" "2709.7" "2844.6" "" "" "" "" "" "" "" "" "" "" "2765.2" "2337.1" "2764.0" "2244.3" "2487.3" "2786.3" "2585.3" "2483.8" "2709.7" "2738.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088102652964782572" "False" "High" "IsMasterProtein" "Q13310" "Polyadenylate-binding protein 4 OS=Homo sapiens OX=9606 GN=PABPC4 PE=1 SV=1" "0.000" "False" "55.151" "25" "15" "34" "11" "644" "70.7" "9.26" "91.96" "15" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00658" "8761" "ENSG00000090621" "PABPC4" "B1ANQ8; hsa:8761; Q13310; Q4VC03; Q6P0N3" "" "" "0" "0" "0.968" "1.041" "1.050" "1.021" "1.017" "0.942" "0.990" "0.975" "0.992" "1597.0" "1546.3" "1662.6" "1676.7" "1631.2" "1624.5" "1504.5" "1580.3" "1556.9" "1584.8" "" "" "" "" "" "" "" "" "" "" "1496.4" "1279.5" "1543.6" "1296.2" "1390.4" "1552.0" "1374.7" "1403.2" "1556.9" "1525.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1304014562382960910" "False" "High" "IsMasterProtein" "O60216" "Double-strand-break repair protein rad21 homolog OS=Homo sapiens OX=9606 GN=RAD21 PE=1 SV=2" "0.000" "False" "55.144" "33" "16" "27" "16" "631" "71.6" "4.65" "86.74" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04824, Pf04825" "5885" "ENSG00000164754" "RAD21" "A8K0E0; hsa:5885; O60216; Q15001; Q99568" "Cell cycle; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "13" "0" "0.995" "1.031" "1.004" "0.977" "0.991" "0.969" "0.973" "1.020" "0.994" "2620.4" "2606.2" "2701.7" "2629.7" "2561.0" "2597.9" "2538.6" "2549.3" "2673.6" "2603.7" "" "" "" "" "" "" "" "" "" "" "2455.3" "2156.6" "2508.2" "2032.9" "2183.0" "2482.1" "2319.6" "2263.5" "2673.6" "2507.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4972619903535100006" "False" "High" "IsMasterProtein" "P49916" "DNA ligase 3 OS=Homo sapiens OX=9606 GN=LIG3 PE=1 SV=2" "0.000" "False" "55.134" "19" "17" "20" "17" "1009" "112.8" "9.01" "64.81" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00645, Pf01068, Pf04675, Pf04679, Pf16759" "3980" "ENSG00000005156" "LIG3" "E5KLB5; E5KLB6; hsa:3980; P49916; Q16714; Q6NVK3" "Base excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 17q12 copy number variation syndrome" "HDR through MMEJ (alt-NHEJ); Gap-filling DNA repair synthesis and ligation in TC-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; Resolution of AP sites via the single-nucleotide replacement pathway" "9" "0" "0.980" "1.032" "0.970" "1.005" "1.019" "0.956" "0.981" "1.017" "1.072" "2511.8" "2462.7" "2591.4" "2435.7" "2523.9" "2559.2" "2400.0" "2463.9" "2553.5" "2692.4" "" "" "" "" "" "" "" "" "" "" "2353.5" "2037.8" "2405.8" "1882.9" "2151.3" "2445.1" "2193.0" "2187.7" "2553.5" "2592.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2657182436335150623" "False" "High" "IsMasterProtein" "Q9Y3I0" "RNA-splicing ligase RtcB homolog OS=Homo sapiens OX=9606 GN=RTCB PE=1 SV=1" "0.000" "False" "55.047" "32" "15" "30" "15" "505" "55.2" "7.23" "91.55" "15" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01139" "51493" "ENSG00000100220" "RTCB" "B2R6A8; hsa:51493; Q6IAI0; Q9BWL4; Q9NTH1; Q9P037; Q9P0J3; Q9Y3I0" "Unfolded protein response" "tRNA processing in the nucleus" "2" "0" "0.986" "1.033" "1.041" "1.013" "1.006" "0.990" "1.049" "1.031" "1.016" "2739.1" "2701.0" "2830.4" "2850.7" "2773.4" "2755.9" "2710.7" "2873.7" "2823.9" "2782.9" "" "" "" "" "" "" "" "" "" "" "2566.5" "2235.1" "2627.7" "2203.7" "2364.0" "2633.0" "2476.9" "2551.5" "2823.9" "2679.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1534536598926653536" "False" "High" "IsMasterProtein" "P05198" "Eukaryotic translation initiation factor 2 subunit 1 OS=Homo sapiens OX=9606 GN=EIF2S1 PE=1 SV=3" "0.000" "False" "55.014" "55" "16" "28" "16" "315" "36.1" "5.08" "93.74" "16" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf00575, Pf07541" "1965" "ENSG00000134001" "EIF2S1" "hsa:1965; P05198" "Translation factors; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebola virus infection in host; Nonalcoholic fatty liver disease; Measles virus infection; Unfolded protein response; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Alzheimer's disease" "ABC-family proteins mediated transport; PKR-mediated signaling; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "21" "0" "0.980" "1.029" "0.998" "1.001" "1.031" "0.968" "0.969" "1.002" "0.996" "2266.6" "2221.5" "2333.4" "2261.5" "2268.7" "2337.2" "2193.3" "2196.6" "2272.2" "2257.0" "" "" "" "" "" "" "" "" "" "" "2123.8" "1838.2" "2166.3" "1748.3" "1933.8" "2233.0" "2004.0" "1950.3" "2272.2" "2173.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6529775950404904251" "False" "High" "IsMasterProtein" "Q9UBC2" "Epidermal growth factor receptor substrate 15-like 1 OS=Homo sapiens OX=9606 GN=EPS15L1 PE=1 SV=1" "0.000" "False" "54.895" "23" "19" "22" "19" "864" "94.2" "5.11" "65.29" "19" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12763" "58513" "ENSG00000127527" "EPS15L1" "A2RRF3; A5PL29; B4DKA3; hsa:58513; Q9UBC2" "EGF/EGFR signaling pathway" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation" "4" "0" "1.046" "1.025" "1.080" "1.056" "1.063" "1.057" "1.059" "1.052" "1.036" "1791.0" "1872.8" "1834.9" "1934.0" "1891.4" "1903.1" "1892.9" "1897.3" "1885.0" "1855.7" "" "" "" "" "" "" "" "" "" "" "1678.1" "1549.7" "1703.5" "1495.1" "1612.2" "1818.2" "1729.6" "1684.6" "1885.0" "1786.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1724337932377857957" "False" "High" "IsMasterProtein" "Q13619" "Cullin-4A OS=Homo sapiens OX=9606 GN=CUL4A PE=1 SV=3" "0.000" "False" "54.893" "21" "19" "23" "10" "759" "87.6" "8.13" "69.22" "19" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8451" "ENSG00000139842" "CUL4A" "A2A2W2; hsa:8451; O75834; Q13619; Q589T6; Q5TC62; Q6UP08; Q9UP17" "Hippo-Merlin signaling dysregulation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Formation of Incision Complex in GG-NER; Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER; Dual Incision in GG-NER" "13" "0" "0.969" "1.005" "0.995" "0.997" "0.982" "0.982" "0.987" "0.970" "1.024" "1669.3" "1617.2" "1677.3" "1660.3" "1664.1" "1638.6" "1639.1" "1647.2" "1619.6" "1709.7" "" "" "" "" "" "" "" "" "" "" "1564.1" "1338.2" "1557.1" "1283.5" "1418.4" "1565.5" "1497.7" "1462.6" "1619.6" "1646.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8642503759764886067" "False" "High" "IsMasterProtein" "P49454" "Centromere protein F OS=Homo sapiens OX=9606 GN=CENPF PE=1 SV=3" "0.000" "False" "54.869" "6" "22" "22" "22" "3114" "357.3" "5.10" "60.16" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10473, Pf10481, Pf10490" "1063" "ENSG00000117724" "CENPF" "hsa:1063; P49454; Q13171; Q13246; Q5VVM7" "Gastric cancer network 1; Ciliopathies" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Polo-like kinase mediated events" "9" "0" "1.017" "0.993" "1.038" "1.005" "1.006" "1.031" "1.045" "1.006" "1.024" "1376.5" "1399.6" "1367.4" "1429.1" "1383.3" "1384.9" "1418.7" "1438.3" "1384.1" "1409.7" "" "" "" "" "" "" "" "" "" "" "1289.8" "1158.1" "1269.4" "1104.8" "1179.1" "1323.2" "1296.3" "1277.1" "1384.1" "1357.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5384337703464320291" "False" "High" "IsMasterProtein" "Q16822" "Phosphoenolpyruvate carboxykinase [GTP], mitochondrial OS=Homo sapiens OX=9606 GN=PCK2 PE=1 SV=4" "0.000" "False" "54.838" "29" "17" "28" "17" "640" "70.7" "7.62" "83.90" "17" "other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00821, Pf17297" "5106" "ENSG00000100889; ENSG00000285241" "PCK2" "B4DW73; hsa:5106; O43253; Q16822; Q86U01; Q9BV62" "Adipogenesis; Transcription factor regulation in adipogenesis; PPAR signaling pathway; PI3K-Akt signaling pathway; Krebs cycle disorders; DNA damage response (only ATM dependent)" "Gluconeogenesis" "7" "0" "0.988" "1.004" "1.021" "1.008" "1.028" "0.977" "0.957" "0.958" "0.984" "1726.9" "1706.5" "1733.2" "1763.0" "1741.1" "1775.3" "1686.5" "1653.0" "1655.0" "1698.9" "" "" "" "" "" "" "" "" "" "" "1618.1" "1412.1" "1609.1" "1362.9" "1484.1" "1696.2" "1541.0" "1467.7" "1655.0" "1635.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2868702294912813046" "False" "High" "IsMasterProtein" "P60174" "Triosephosphate isomerase OS=Homo sapiens OX=9606 GN=TPI1 PE=1 SV=4" "0.000" "False" "54.778" "68" "15" "32" "15" "249" "26.7" "6.90" "115.28" "15" "other metabolic processes" "cytosol" "other molecular function" "Pf00121" "7167" "ENSG00000111669" "TPI1" "B7Z5D8; D3DUS9; hsa:7167; P00938; P60174; Q6FHP9; Q6IS07; Q8WWD0; Q96AG5" "Fatty acid beta-oxidation; Cori cycle; HIF1A and PPARG regulation of glycolysis; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis" "10" "0" "0.998" "0.980" "1.015" "0.986" "0.995" "0.944" "0.986" "0.964" "0.987" "3560.7" "3554.8" "3490.4" "3613.1" "3510.0" "3544.7" "3360.1" "3509.2" "3430.8" "3514.9" "" "" "" "" "" "" "" "" "" "" "3336.4" "2941.6" "3240.4" "2793.1" "2991.8" "3386.6" "3070.3" "3115.8" "3430.8" "3384.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2064458318068970757" "False" "High" "IsMasterProtein" "Q96QK1" "Vacuolar protein sorting-associated protein 35 OS=Homo sapiens OX=9606 GN=VPS35 PE=1 SV=2" "0.000" "False" "54.770" "21" "16" "36" "16" "796" "91.6" "5.49" "121.23" "16" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding" "Pf03635" "55737" "ENSG00000069329" "VPS35" "hsa:55737; Q561W2; Q96QK1; Q9H016; Q9H096; Q9H4P3; Q9H8J0; Q9NRS7; Q9NVG2; Q9NX80; Q9NZK2" "" "WNT ligand biogenesis and trafficking" "1" "0" "1.005" "1.064" "1.073" "1.034" "1.034" "1.037" "1.062" "1.057" "1.048" "2933.9" "2947.9" "3120.4" "3147.4" "3032.5" "3032.7" "3041.8" "3115.7" "3101.8" "3073.4" "" "" "" "" "" "" "" "" "" "" "2749.1" "2439.3" "2896.9" "2433.1" "2584.8" "2897.4" "2779.4" "2766.4" "3101.8" "2959.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3080832168399393297" "False" "High" "IsMasterProtein" "Q9Y6D6" "Brefeldin A-inhibited guanine nucleotide-exchange protein 1 OS=Homo sapiens OX=9606 GN=ARFGEF1 PE=1 SV=2" "0.000" "False" "54.715" "11" "21" "25" "13" "1849" "208.6" "5.85" "77.92" "21" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf01369, Pf09324, Pf12783, Pf16213, Pf20252" "10565" "ENSG00000066777" "ARFGEF1" "hsa:10565; Q9NV46; Q9UFV2; Q9UNL0; Q9Y6D6" "" "" "0" "4" "1.004" "1.003" "1.012" "1.008" "1.017" "0.935" "0.902" "0.921" "0.991" "2756.8" "2767.1" "2764.5" "2789.2" "2777.9" "2804.4" "2576.7" "2486.4" "2539.0" "2732.3" "" "" "" "" "" "" "" "" "" "" "2583.1" "2289.7" "2566.5" "2156.2" "2367.8" "2679.3" "2354.4" "2207.7" "2539.0" "2630.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5095696648215945885" "False" "High" "IsMasterProtein" "P09972" "Fructose-bisphosphate aldolase C OS=Homo sapiens OX=9606 GN=ALDOC PE=1 SV=2" "0.000" "False" "54.636" "51" "18" "47" "13" "364" "39.4" "6.87" "177.68" "18" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00274" "230" "ENSG00000109107" "ALDOC" "B2R5R3; hsa:230; P09972; Q3SYL3; Q6FH94; Q6P0L5" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Neutrophil degranulation; Glycolysis; Gluconeogenesis" "6" "0" "1.111" "1.017" "1.202" "1.098" "1.026" "1.030" "1.031" "1.056" "1.028" "1237.7" "1375.6" "1259.3" "1487.2" "1358.4" "1269.3" "1275.4" "1276.4" "1306.7" "1272.8" "" "" "" "" "" "" "" "" "" "" "1159.7" "1138.3" "1169.1" "1149.7" "1157.8" "1212.7" "1165.4" "1133.3" "1306.7" "1225.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6373190460563601224" "False" "High" "IsMasterProtein" "Q7L014" "Probable ATP-dependent RNA helicase DDX46 OS=Homo sapiens OX=9606 GN=DDX46 PE=1 SV=2" "0.000" "False" "54.591" "16" "18" "23" "18" "1031" "117.3" "9.29" "70.34" "18" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;nucleus" "other molecular function" "Pf00270, Pf00271" "9879" "ENSG00000145833" "DDX46" "hsa:9879; O94894; Q7L014; Q96EI0; Q9Y658" "" "mRNA Splicing - Major Pathway" "1" "0" "1.065" "1.077" "0.978" "0.999" "1.048" "1.145" "1.198" "1.219" "1.155" "1510.1" "1608.2" "1626.4" "1476.9" "1508.6" "1582.5" "1729.4" "1809.0" "1840.8" "1743.7" "" "" "" "" "" "" "" "" "" "" "1415.0" "1330.8" "1509.9" "1141.7" "1285.9" "1512.0" "1580.3" "1606.2" "1840.8" "1679.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4807008432777767819" "False" "High" "IsMasterProtein" "Q9NTZ6" "RNA-binding protein 12 OS=Homo sapiens OX=9606 GN=RBM12 PE=1 SV=1" "0.000" "False" "54.547" "20" "17" "26" "17" "932" "97.3" "8.63" "79.32" "17" "other biological processes" "nucleus;other cell component" "" "Pf00076" "10137" "ENSG00000244462" "RBM12" "B3KRU2; E1P5R6; hsa:10137; O94865; Q8N3B1; Q9H196; Q9NTZ6" "" "" "0" "0" "0.952" "0.969" "0.976" "0.964" "0.957" "0.983" "0.990" "0.974" "0.979" "3540.5" "3370.6" "3432.3" "3453.9" "3413.2" "3387.9" "3479.4" "3506.1" "3450.1" "3467.4" "" "" "" "" "" "" "" "" "" "" "3317.5" "2789.2" "3186.5" "2670.0" "2909.3" "3236.9" "3179.2" "3113.1" "3450.1" "3338.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9088967002815659299" "False" "High" "IsMasterProtein" "P26641" "Elongation factor 1-gamma OS=Homo sapiens OX=9606 GN=EEF1G PE=1 SV=3" "0.000" "False" "54.529" "33" "16" "44" "16" "437" "50.1" "6.67" "134.93" "16" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf00043, Pf00647, Pf02798" "1937" "ENSG00000254772" "EEF1G" "B4DTG2; hsa:1937; P26641; Q6PJ62; Q6PK31; Q96CU2; Q9P196" "Translation factors" "Signaling by ALK fusions and activated point mutants; Eukaryotic Translation Elongation" "3" "0" "1.036" "1.020" "1.029" "0.977" "0.956" "0.912" "0.975" "0.993" "0.964" "4112.4" "4260.0" "4196.3" "4231.9" "4018.1" "3932.4" "3748.5" "4010.3" "4082.2" "3962.7" "" "" "" "" "" "" "" "" "" "" "3853.3" "3525.1" "3895.7" "3271.5" "3424.9" "3757.0" "3425.1" "3560.7" "4082.2" "3815.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "769140260772308897" "False" "High" "IsMasterProtein" "P07910" "Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Homo sapiens OX=9606 GN=HNRNPC PE=1 SV=4" "0.000" "False" "54.510" "43" "16" "28" "16" "306" "33.7" "5.08" "93.55" "16" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "3183" "ENSG00000092199" "HNRNPC" "D3DS19; D3DS22; hsa:3183; P07910; P22628; Q53EX2; Q59FD3; Q5FWE8; Q86SF8; Q86U45; Q96HK7; Q96HM4; Q96IY5; Q9BTS3" "mRNA processing" "SUMOylation of RNA binding proteins; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "6" "0" "1.305" "1.309" "1.043" "0.729" "0.747" "0.980" "0.778" "0.998" "0.993" "3060.9" "3995.2" "4007.9" "3191.5" "2232.4" "2285.8" "3000.6" "2382.1" "3055.6" "3040.5" "" "" "" "" "" "" "" "" "" "" "2868.0" "3306.0" "3720.8" "2467.2" "1902.8" "2183.9" "2741.8" "2115.1" "3055.6" "2927.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6072286448447602827" "False" "High" "IsMasterProtein" "Q9UBE0" "SUMO-activating enzyme subunit 1 OS=Homo sapiens OX=9606 GN=SAE1 PE=1 SV=1" "0.000" "False" "54.475" "51" "16" "26" "16" "346" "38.4" "5.30" "86.20" "16" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00899" "10055" "ENSG00000142230" "SAE1" "B2RDP5; B3KMQ2; F5GXX7; G3XAK6; hsa:10055; O95717; Q9P020; Q9UBE0" "" "SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "2" "0" "0.939" "0.974" "0.944" "0.929" "0.925" "0.911" "0.943" "0.930" "0.925" "2570.4" "2413.3" "2504.3" "2425.4" "2387.6" "2377.1" "2342.6" "2424.7" "2389.2" "2377.8" "" "" "" "" "" "" "" "" "" "" "2408.5" "1997.0" "2324.9" "1874.9" "2035.1" "2271.1" "2140.5" "2152.9" "2389.2" "2289.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1892947756111346869" "False" "High" "IsMasterProtein" "P42345" "Serine/threonine-protein kinase mTOR OS=Homo sapiens OX=9606 GN=MTOR PE=1 SV=1" "0.000" "False" "54.438" "8" "22" "25" "22" "2549" "288.7" "7.17" "66.02" "22" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "translation activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08771, Pf11865" "2475" "ENSG00000198793" "MTOR" "hsa:2475; P42345; Q4LE76; Q5TER1; Q6LE87; Q96QG3; Q9Y4I3" "AMP-activated protein kinase signaling; Target of rapamycin signaling; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Polycystic kidney disease pathway; Cardiac hypertrophic response; Extracellular vesicle-mediated signaling in recipient cells; TSLP signaling pathway; Ovarian infertility; MECP2 and associated Rett syndrome; Wnt signaling pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; ATM signaling in development and disease ; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Caloric restriction and aging; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Thermogenesis; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Joubert syndrome; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; CAMKK2 pathway; Neuroinflammation; Autophagy; p53 transcriptional gene network; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Network map of SARS-CoV-2 signaling pathway; Sphingolipid metabolism in senescence; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Clock-controlled autophagy in bone metabolism; Warburg effect modulated by deubiquitinating enzymes and their substrates; Acute myeloid leukemia; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map; JAK-STAT signaling in the regulation of beta cells; ADHD and autism (ASD) linked metabolic pathways and SNP; GNAQ pathways in port-wine stain; Artemisinin inhibition of uveal melanoma; Interferon type I signaling pathways; ErbB signaling pathway" "Amino acids regulate mTORC1; Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; Regulation of PTEN gene transcription; mTORC1-mediated signalling; CD28 dependent PI3K/Akt signaling; TP53 Regulates Metabolic Genes; VEGFR2 mediated vascular permeability; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; HSF1-dependent transactivation" "92" "0" "1.006" "1.008" "0.993" "1.015" "1.000" "0.970" "0.968" "1.015" "1.002" "1802.8" "1812.9" "1816.5" "1790.1" "1829.9" "1803.6" "1748.5" "1745.7" "1829.9" "1806.9" "" "" "" "" "" "" "" "" "" "" "1689.2" "1500.2" "1686.4" "1383.9" "1559.8" "1723.1" "1597.6" "1550.0" "1829.9" "1739.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8586713697824146806" "False" "High" "IsMasterProtein" "P46379" "Large proline-rich protein BAG6 OS=Homo sapiens OX=9606 GN=BAG6 PE=1 SV=2" "0.000" "False" "54.430" "16" "15" "25" "15" "1132" "119.3" "5.60" "90.36" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;translation activity;other molecular function" "Pf00240, Pf12057, Pf20960" "7917" "ENSG00000096155; ENSG00000204463; ENSG00000227761; ENSG00000228760; ENSG00000229524; ENSG00000233348; ENSG00000234651" "BAG6" "A2ADJ7; A3KQ42; A3KQ44; A6NGY6; A6PWF7; B0UX84; B4DZ12; B4E3V4; E7EMZ4; F8VXY4; hsa:7917; O95874; P46379; Q5HYL9; Q5SQ35; Q5SQ36; Q5SQ37; Q5SQ41; Q5SRP8; Q5SRP9; Q5STC1; Q5STX1; Q5STX3; Q96SA6; Q9BCN4" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "0.968" "0.995" "1.011" "0.976" "0.991" "0.999" "1.012" "0.979" "0.970" "2258.3" "2185.7" "2247.3" "2282.8" "2204.0" "2237.2" "2255.0" "2284.8" "2211.5" "2189.6" "" "" "" "" "" "" "" "" "" "" "2116.0" "1808.7" "2086.3" "1764.7" "1878.7" "2137.4" "2060.5" "2028.6" "2211.5" "2108.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3535367266353514153" "False" "High" "IsMasterProtein" "O00160" "Unconventional myosin-If OS=Homo sapiens OX=9606 GN=MYO1F PE=1 SV=3" "0.000" "False" "54.413" "15" "18" "21" "18" "1098" "124.8" "9.11" "65.75" "18" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf00063, Pf06017" "4542" "ENSG00000142347" "MYO1F" "O00160; Q8WWN7" "" "" "0" "0" "0.991" "1.024" "1.022" "1.017" "1.065" "0.978" "1.004" "1.048" "1.037" "2639.4" "2614.7" "2702.1" "2696.8" "2684.1" "2811.1" "2581.5" "2651.0" "2765.0" "2737.4" "" "" "" "" "" "" "" "" "" "" "2473.1" "2163.7" "2508.5" "2084.7" "2287.9" "2685.7" "2358.8" "2353.8" "2765.0" "2635.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3093573351125982310" "False" "High" "IsMasterProtein" "Q86WJ1" "Chromodomain-helicase-DNA-binding protein 1-like OS=Homo sapiens OX=9606 GN=CHD1L PE=1 SV=3" "0.000" "False" "54.410" "21" "18" "23" "18" "897" "100.9" "6.90" "75.83" "18" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00176, Pf00271" "9557" "ENSG00000131778" "CHD1L" "A5YM64; B4DDE1; B5MDZ7; Q53EZ3; Q5VXX7; Q6DD94; Q6PK83; Q86WJ1; Q86XH3; Q96HF7; Q96SP3; Q9BVJ1; Q9NVV8" "1q21.1 copy number variation syndrome; Nucleotide excision repair in xeroderma pigmentosum" "Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "4" "0" "1.000" "1.014" "1.030" "1.061" "1.044" "1.012" "1.037" "1.013" "1.032" "2249.7" "2249.1" "2280.4" "2316.8" "2387.6" "2348.4" "2276.2" "2331.9" "2278.4" "2322.1" "" "" "" "" "" "" "" "" "" "" "2108.0" "1861.1" "2117.0" "1791.0" "2035.2" "2243.7" "2079.8" "2070.5" "2278.4" "2235.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6844923263172623256" "False" "High" "IsMasterProtein" "Q9BXP5" "Serrate RNA effector molecule homolog OS=Homo sapiens OX=9606 GN=SRRT PE=1 SV=1" "0.000" "False" "54.393" "18" "17" "24" "17" "876" "100.6" "5.96" "76.80" "17" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04959, Pf12066" "51593" "ENSG00000087087" "SRRT" "A4D2E5; A4D2E6; A6NK22; B4DJL4; B4DZA6; hsa:51593; O95808; Q32MI4; Q6NT74; Q8TDQ5; Q9BWP6; Q9BXP4; Q9BXP5; Q9Y4S4" "" "mRNA Splicing - Major Pathway; RNA polymerase II transcribes snRNA genes" "2" "0" "0.914" "1.048" "1.001" "1.097" "1.062" "1.212" "1.246" "1.140" "1.087" "3188.7" "2914.1" "3342.4" "3193.5" "3497.8" "3387.3" "3864.2" "3973.5" "3635.1" "3465.0" "" "" "" "" "" "" "" "" "" "" "2987.8" "2411.4" "3103.0" "2468.7" "2981.5" "3236.2" "3530.8" "3528.0" "3635.1" "3336.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1811724669038293962" "False" "High" "IsMasterProtein" "Q96RP9" "Elongation factor G, mitochondrial OS=Homo sapiens OX=9606 GN=GFM1 PE=1 SV=2" "0.000" "False" "54.321" "23" "17" "26" "17" "751" "83.4" "7.01" "81.09" "17" "protein metabolism;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "85476" "ENSG00000168827" "GFM1" "A6NCI9; B2RCB9; B3KRW1; hsa:85476; Q6GTN2; Q96RP9; Q96T39" "" "Mitochondrial translation elongation" "1" "0" "0.960" "1.031" "0.918" "0.976" "0.990" "0.946" "0.971" "0.974" "0.984" "2896.4" "2781.4" "2985.2" "2658.2" "2826.7" "2868.0" "2739.8" "2813.3" "2820.9" "2849.0" "" "" "" "" "" "" "" "" "" "" "2713.9" "2301.6" "2771.3" "2054.9" "2409.4" "2740.1" "2503.5" "2498.0" "2820.9" "2743.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4830366311257218609" "False" "High" "IsMasterProtein" "P48147" "Prolyl endopeptidase OS=Homo sapiens OX=9606 GN=PREP PE=1 SV=2" "0.000" "False" "54.286" "25" "16" "21" "16" "710" "80.6" "5.86" "69.51" "16" "protein metabolism" "cytosol;nucleus;other cell component" "other molecular function" "Pf00326, Pf02897" "5550" "ENSG00000085377" "PREP" "hsa:5550; P48147; Q8N6D4" "" "" "0" "0" "0.967" "1.004" "0.979" "0.988" "0.980" "0.959" "0.992" "0.985" "0.977" "2784.2" "2691.2" "2795.7" "2726.6" "2751.3" "2729.0" "2671.3" "2761.7" "2741.6" "2719.1" "" "" "" "" "" "" "" "" "" "" "2608.8" "2227.0" "2595.5" "2107.8" "2345.1" "2607.3" "2440.9" "2452.1" "2741.6" "2618.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4107495286689168051" "False" "High" "IsMasterProtein" "P42566" "Epidermal growth factor receptor substrate 15 OS=Homo sapiens OX=9606 GN=EPS15 PE=1 SV=2" "0.000" "False" "54.278" "21" "18" "23" "18" "896" "98.6" "4.64" "70.12" "18" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "" "2060" "ENSG00000085832" "EPS15" "B2R8J7; D3DPJ2; hsa:2060; P42566; Q5SRH4" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; EGF/EGFR signaling pathway" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "8" "0" "1.010" "0.999" "0.966" "1.009" "1.005" "0.989" "0.987" "0.990" "1.010" "3577.6" "3613.2" "3573.6" "3457.1" "3608.6" "3594.1" "3539.5" "3531.4" "3540.8" "3612.3" "" "" "" "" "" "" "" "" "" "" "3352.2" "2989.9" "3317.6" "2672.5" "3075.9" "3433.8" "3234.1" "3135.5" "3540.8" "3478.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8256721828910616389" "False" "High" "IsMasterProtein" "P55196" "Afadin OS=Homo sapiens OX=9606 GN=AFDN PE=1 SV=3" "0.000" "False" "54.096" "11" "18" "23" "18" "1824" "206.7" "6.47" "74.29" "18" "cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00498, Pf00595, Pf00788, Pf01843" "4301" "ENSG00000130396" "AFDN" "O75087; O75088; O75089; P55196; Q59FP0; Q5TIG6; Q5TIG7; Q9NSN7; Q9NU92" "VEGFA-VEGFR2 signaling; Ras signaling; 1q21.1 copy number variation syndrome" "" "3" "0" "1.024" "1.076" "1.056" "1.069" "1.060" "1.094" "1.105" "1.069" "1.081" "1369.9" "1403.3" "1473.5" "1446.1" "1465.1" "1452.4" "1498.8" "1513.3" "1464.5" "1481.0" "" "" "" "" "" "" "" "" "" "" "1283.6" "1161.2" "1368.0" "1117.9" "1248.8" "1387.7" "1369.5" "1343.7" "1464.5" "1426.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8809117759024256443" "False" "High" "IsMasterProtein" "P29692" "Elongation factor 1-delta OS=Homo sapiens OX=9606 GN=EEF1D PE=1 SV=5" "0.000" "False" "53.922" "60" "14" "30" "12" "281" "31.1" "5.01" "99.45" "14" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00736, Pf10587" "1936" "ENSG00000104529; ENSG00000273594" "EEF1D" "B4DDU4; D3DWK3; E9PBQ9; hsa:1936; P29692; Q4VBZ6; Q969J1; Q96I38" "Translation factors" "Eukaryotic Translation Elongation" "2" "2" "0.965" "0.963" "0.969" "0.960" "0.939" "0.927" "0.949" "0.975" "0.960" "2304.1" "2223.8" "2218.9" "2231.9" "2213.1" "2163.4" "2136.5" "2186.6" "2247.0" "2212.9" "" "" "" "" "" "" "" "" "" "" "2159.0" "1840.1" "2060.0" "1725.4" "1886.4" "2066.9" "1952.1" "1941.5" "2247.0" "2130.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1853475733980272119" "False" "High" "IsMasterProtein" "P17858" "ATP-dependent 6-phosphofructokinase, liver type OS=Homo sapiens OX=9606 GN=PFKL PE=1 SV=6" "0.000" "False" "53.769" "23" "19" "32" "13" "780" "85.0" "7.50" "86.71" "19" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "kinase activity;other molecular function" "Pf00365" "5211" "ENSG00000141959" "PFKL" "hsa:5211; P17858; Q96A64; Q96IH4; Q9BR91" "Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Insulin signaling; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Neutrophil degranulation; Glycolysis" "9" "1" "1.015" "1.009" "1.024" "1.019" "1.045" "0.995" "0.983" "0.969" "0.977" "1706.9" "1732.1" "1721.5" "1747.3" "1739.7" "1784.0" "1699.0" "1677.4" "1654.6" "1666.9" "" "" "" "" "" "" "" "" "" "" "1599.4" "1433.3" "1598.2" "1350.7" "1482.9" "1704.5" "1552.4" "1489.4" "1654.6" "1605.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "500586164942944818" "False" "High" "IsMasterProtein" "P67809" "Y-box-binding protein 1 OS=Homo sapiens OX=9606 GN=YBX1 PE=1 SV=3" "0.000" "False" "53.737" "52" "12" "23" "9" "324" "35.9" "9.88" "84.19" "12" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00313" "4904" "ENSG00000065978" "YBX1" "hsa:4904; P16990; P16991; P67809; Q14972; Q15325; Q5FVF0" "Brain-derived neurotrophic factor (BDNF) signaling pathway; MECP2 and associated Rett syndrome; mRNA processing; Sudden infant death syndrome (SIDS) susceptibility pathways" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Interferon gamma signaling; Noncanonical activation of NOTCH3" "10" "3" "1.059" "1.062" "1.010" "0.999" "0.974" "0.973" "0.926" "0.987" "1.001" "2482.6" "2629.0" "2635.4" "2508.6" "2479.1" "2418.8" "2414.6" "2299.7" "2450.0" "2484.1" "" "" "" "" "" "" "" "" "" "" "2326.2" "2175.4" "2446.6" "1939.2" "2113.2" "2311.0" "2206.3" "2041.9" "2450.0" "2391.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4598318327767700223" "False" "High" "IsMasterProtein" "Q96SI9" "Spermatid perinuclear RNA-binding protein OS=Homo sapiens OX=9606 GN=STRBP PE=1 SV=1" "0.000" "False" "53.692" "24" "16" "27" "11" "672" "73.6" "8.72" "87.41" "16" "other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity" "Pf00035, Pf07528, Pf20965" "55342" "ENSG00000165209" "STRBP" "hsa:55342; Q32NB9; Q96SI9; Q9BUE1; Q9BXG4; Q9H0B4; Q9H7V1; Q9NUK4" "" "" "0" "0" "0.964" "1.001" "0.982" "1.030" "1.041" "0.984" "1.060" "1.032" "1.050" "1533.1" "1478.2" "1534.1" "1504.9" "1579.4" "1596.5" "1509.3" "1624.9" "1582.6" "1610.2" "" "" "" "" "" "" "" "" "" "" "1436.5" "1223.2" "1424.3" "1163.4" "1346.2" "1525.4" "1379.1" "1442.8" "1582.6" "1550.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7060921209574590531" "False" "High" "IsMasterProtein" "Q01780" "Exosome complex component 10 OS=Homo sapiens OX=9606 GN=EXOSC10 PE=1 SV=2" "0.000" "False" "53.641" "22" "21" "24" "21" "885" "100.8" "8.46" "66.60" "21" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00570, Pf01612, Pf08066" "5394" "ENSG00000171824" "EXOSC10" "B1AKQ0; B1AKQ1; hsa:5394; Q01780; Q15158" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.008" "0.997" "0.985" "1.052" "1.022" "1.028" "1.028" "0.998" "1.041" "2657.6" "2679.5" "2649.9" "2618.7" "2795.0" "2717.2" "2731.2" "2732.2" "2651.3" "2766.5" "" "" "" "" "" "" "" "" "" "" "2490.2" "2217.2" "2460.1" "2024.3" "2382.4" "2596.0" "2495.6" "2425.9" "2651.3" "2663.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4660808662127601060" "False" "High" "IsMasterProtein" "Q9NR09" "Baculoviral IAP repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=BIRC6 PE=1 SV=3" "0.000" "False" "53.502" "4" "23" "26" "23" "4857" "529.9" "6.05" "69.25" "23" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00179, Pf00653, Pf12356" "57448" "ENSG00000115760" "BIRC6" "hsa:57448; Q9NR09; Q9ULD1" "" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "2" "0" "0.973" "0.971" "0.993" "0.982" "0.971" "0.932" "0.915" "0.924" "0.982" "2964.4" "2883.4" "2879.2" "2943.1" "2910.7" "2878.1" "2762.7" "2711.6" "2738.2" "2909.9" "" "" "" "" "" "" "" "" "" "" "2777.7" "2386.0" "2673.0" "2275.1" "2481.0" "2749.7" "2524.3" "2407.6" "2738.2" "2801.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1017068245716453317" "False" "High" "IsMasterProtein" "O95782" "AP-2 complex subunit alpha-1 OS=Homo sapiens OX=9606 GN=AP2A1 PE=1 SV=3" "0.000" "False" "53.221" "19" "20" "33" "13" "977" "107.5" "7.03" "84.80" "20" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01602, Pf02296, Pf02883" "160" "ENSG00000196961" "AP2A1" "hsa:160; O95782; Q96CI7; Q96PP6; Q96PP7; Q9H070" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission; Cell lineage map for neuronal differentiation" "Potential therapeutics for SARS; Recycling pathway of L1; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Trafficking of GluR2-containing AMPA receptors; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "21" "5" "0.963" "1.050" "1.002" "1.007" "1.021" "1.035" "1.019" "1.030" "1.005" "4064.1" "3914.0" "4268.1" "4070.9" "4091.6" "4148.0" "4207.4" "4141.6" "4187.2" "4082.7" "" "" "" "" "" "" "" "" "" "" "3808.0" "3238.8" "3962.4" "3147.0" "3487.6" "3963.0" "3844.5" "3677.3" "4187.2" "3931.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "376281410555249272" "False" "High" "IsMasterProtein" "O75592" "E3 ubiquitin-protein ligase MYCBP2 OS=Homo sapiens OX=9606 GN=MYCBP2 PE=1 SV=4" "0.000" "False" "53.210" "4" "21" "26" "21" "4678" "513.3" "7.02" "77.96" "21" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00415, Pf03256, Pf08005, Pf13540" "23077" "ENSG00000005810" "MYCBP2" "A6NJC6; O75592; Q5JSX8; Q5VZN6; Q6PIB6; Q9UQ11; Q9Y6E4" "3q29 copy number variation syndrome" "" "1" "0" "0.966" "0.989" "1.015" "0.980" "0.928" "0.878" "0.846" "0.866" "0.987" "1193.4" "1152.6" "1180.0" "1211.5" "1168.9" "1107.0" "1047.7" "1009.6" "1033.2" "1177.5" "" "" "" "" "" "" "" "" "" "" "1118.2" "953.7" "1095.5" "936.6" "996.4" "1057.6" "957.4" "896.4" "1033.2" "1133.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7082716862048425116" "False" "High" "IsMasterProtein" "Q9BPX3" "Condensin complex subunit 3 OS=Homo sapiens OX=9606 GN=NCAPG PE=1 SV=1" "0.000" "False" "53.143" "21" "18" "24" "18" "1015" "114.3" "5.59" "77.84" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "Pf12719" "64151" "ENSG00000109805" "NCAPG" "hsa:64151; Q3MJE0; Q96SV9; Q9BPX3; Q9BUR3; Q9BVY1; Q9H914; Q9H9Z6; Q9HBI9" "" "Condensation of Prometaphase Chromosomes" "1" "0" "0.958" "0.988" "0.939" "0.948" "0.957" "0.867" "0.865" "0.864" "0.931" "3862.2" "3701.4" "3816.6" "3627.4" "3662.6" "3694.8" "3346.7" "3342.6" "3337.2" "3596.3" "" "" "" "" "" "" "" "" "" "" "3618.9" "3062.8" "3543.2" "2804.2" "3121.9" "3530.0" "3058.0" "2967.9" "3337.2" "3462.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "479686062085054609" "False" "High" "IsMasterProtein" "Q15365" "Poly(rC)-binding protein 1 OS=Homo sapiens OX=9606 GN=PCBP1 PE=1 SV=2" "0.000" "False" "53.115" "46" "12" "24" "7" "356" "37.5" "7.09" "89.27" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "5093" "ENSG00000169564" "PCBP1" "hsa:5093; Q13157; Q14975; Q15365" "Ferroptosis" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "3" "5" "0.953" "1.003" "0.958" "0.931" "0.945" "0.934" "0.965" "0.934" "0.917" "3265.2" "3111.5" "3274.4" "3128.9" "3041.5" "3085.5" "3048.3" "3151.3" "3049.5" "2993.0" "" "" "" "" "" "" "" "" "" "" "3059.5" "2574.8" "3039.9" "2418.8" "2592.5" "2947.9" "2785.3" "2798.1" "3049.5" "2881.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1449875230825116072" "False" "High" "IsMasterProtein" "Q03252" "Lamin-B2 OS=Homo sapiens OX=9606 GN=LMNB2 PE=1 SV=4" "0.000" "False" "52.987" "27" "17" "25" "15" "620" "69.9" "5.59" "69.16" "17" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00038, Pf00932" "84823" "ENSG00000176619" "LMNB2" "hsa:84823; O75292; Q03252; Q14734; Q96DF6" "Gastric cancer network 2; Fas ligand pathway and stress induction of heat shock proteins; IL-18 signaling pathway; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "" "6" "0" "1.038" "1.013" "1.186" "1.184" "1.100" "1.938" "1.923" "1.851" "1.342" "1232.8" "1279.1" "1248.7" "1462.5" "1459.5" "1356.1" "2389.4" "2371.1" "2281.3" "1654.2" "" "" "" "" "" "" "" "" "" "" "1155.1" "1058.4" "1159.2" "1130.6" "1244.0" "1295.6" "2183.2" "2105.3" "2281.3" "1592.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2337219862284108106" "False" "High" "IsMasterProtein" "Q9Y262" "Eukaryotic translation initiation factor 3 subunit L OS=Homo sapiens OX=9606 GN=EIF3L PE=1 SV=1" "0.000" "False" "52.926" "31" "16" "20" "16" "564" "66.7" "6.34" "75.36" "16" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf10255" "51386" "ENSG00000100129" "EIF3L" "B2RDG6; B4DYB2; G8JLH4; hsa:51386; Q53HQ1; Q53HT4; Q5QTR1; Q5TI15; Q6ICD2; Q9Y262" "" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "6" "0" "0.956" "1.016" "0.928" "0.904" "0.881" "1.114" "1.123" "1.076" "0.990" "3155.6" "3015.8" "3205.9" "2927.9" "2852.2" "2779.8" "3515.9" "3543.8" "3395.7" "3123.0" "" "" "" "" "" "" "" "" "" "" "2956.8" "2495.5" "2976.3" "2263.4" "2431.1" "2655.9" "3212.6" "3146.6" "3395.7" "3007.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819248738273411506" "False" "High" "IsMasterProtein" "O14981" "TATA-binding protein-associated factor 172 OS=Homo sapiens OX=9606 GN=BTAF1 PE=1 SV=2" "0.000" "False" "52.879" "10" "18" "19" "18" "1849" "206.8" "6.52" "53.36" "18" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf12054" "9044" "ENSG00000095564" "BTAF1" "B4E0W6; hsa:9044; O14981; O43578" "" "" "0" "0" "0.987" "0.971" "1.061" "1.006" "0.988" "0.969" "0.961" "0.978" "0.997" "2782.3" "2744.9" "2702.5" "2952.7" "2798.7" "2748.8" "2695.6" "2673.9" "2720.4" "2774.9" "" "" "" "" "" "" "" "" "" "" "2607.0" "2271.4" "2508.9" "2282.6" "2385.5" "2626.2" "2463.1" "2374.1" "2720.4" "2671.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "92352165089450524" "False" "High" "IsMasterProtein" "O15355" "Protein phosphatase 1G OS=Homo sapiens OX=9606 GN=PPM1G PE=1 SV=1" "0.000" "False" "52.784" "31" "16" "23" "16" "546" "59.2" "4.36" "77.22" "16" "protein metabolism;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf00481" "5496" "ENSG00000115241" "PPM1G" "hsa:5496; O15355" "VEGFA-VEGFR2 signaling; mRNA processing" "" "2" "0" "1.005" "1.000" "0.965" "1.002" "0.988" "0.968" "1.025" "1.004" "0.999" "3046.5" "3062.5" "3047.2" "2940.8" "3051.4" "3011.0" "2949.1" "3121.3" "3058.1" "3043.9" "" "" "" "" "" "" "" "" "" "" "2854.6" "2534.2" "2828.9" "2273.4" "2600.9" "2876.7" "2694.7" "2771.4" "3058.1" "2930.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3541019235990541605" "False" "High" "IsMasterProtein" "Q9UNM6" "26S proteasome non-ATPase regulatory subunit 13 OS=Homo sapiens OX=9606 GN=PSMD13 PE=1 SV=2" "0.000" "False" "52.755" "47" "17" "26" "17" "376" "42.9" "5.81" "82.89" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01399" "5719" "ENSG00000185627" "PSMD13" "B3KT15; hsa:5719; O75831; Q53XU2; Q9UNM6; Q9UNV3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "0.884" "0.954" "0.934" "0.924" "0.916" "0.901" "0.917" "0.904" "0.911" "3804.7" "3362.4" "3628.0" "3554.3" "3513.9" "3486.5" "3426.4" "3489.3" "3441.1" "3466.0" "" "" "" "" "" "" "" "" "" "" "3565.0" "2782.4" "3368.2" "2747.7" "2995.1" "3331.0" "3130.8" "3098.1" "3441.1" "3337.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5197563919464376950" "False" "High" "IsMasterProtein" "Q9BTC0" "Death-inducer obliterator 1 OS=Homo sapiens OX=9606 GN=DIDO1 PE=1 SV=5" "0.000" "False" "52.654" "8" "19" "20" "19" "2240" "243.7" "7.88" "66.21" "19" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00628, Pf07500, Pf07744" "11083" "ENSG00000101191" "DIDO1" "A8MY65; B9EH82; E1P5I1; hsa:11083; O15043; Q3ZTL7; Q3ZTL8; Q4VXS1; Q4VXS2; Q4VXV8; Q4VXV9; Q96D72; Q9BQW0; Q9BTC0; Q9BW03; Q9H4G6; Q9H4G7; Q9NTU8; Q9NUM8; Q9UFB6" "" "" "0" "0" "1.062" "1.039" "1.016" "1.050" "1.023" "1.051" "1.128" "1.075" "1.062" "1721.6" "1829.0" "1788.0" "1749.3" "1806.9" "1761.2" "1809.4" "1941.9" "1851.2" "1828.1" "" "" "" "" "" "" "" "" "" "" "1613.1" "1513.5" "1659.9" "1352.3" "1540.1" "1682.6" "1653.3" "1724.2" "1851.2" "1760.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6460139479284416051" "False" "High" "IsMasterProtein" "Q86UK7" "E3 ubiquitin-protein ligase ZNF598 OS=Homo sapiens OX=9606 GN=ZNF598 PE=1 SV=1" "0.000" "False" "52.583" "20" "16" "20" "16" "904" "98.6" "8.40" "63.48" "16" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "translation activity;other molecular function" "" "90850" "" "ZNF598" "hsa:90850; Q86UK7; Q8IW49; Q8N3D9; Q96FG3; Q9H7J3" "" "" "0" "0" "1.050" "1.066" "1.065" "1.058" "1.061" "1.085" "1.099" "1.096" "1.099" "1602.6" "1682.8" "1708.5" "1707.1" "1696.1" "1700.4" "1738.2" "1761.1" "1756.5" "1761.8" "" "" "" "" "" "" "" "" "" "" "1501.7" "1392.5" "1586.2" "1319.7" "1445.7" "1624.5" "1588.3" "1563.7" "1756.5" "1696.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3813032805198607075" "False" "High" "IsMasterProtein" "Q9NVA2" "Septin-11 OS=Homo sapiens OX=9606 GN=SEPTIN11 PE=1 SV=3" "0.000" "False" "52.548" "31" "12" "27" "4" "429" "49.4" "6.81" "86.29" "12" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00735" "55752" "ENSG00000138758" "SEPTIN11" "B7Z7Z6; E9KL32; hsa:55752; Q4W5G1; Q7L4N1; Q96SP1; Q9NVA2; Q9UFY9" "22q11.2 copy number variation syndrome" "" "1" "1" "1.006" "1.017" "0.992" "0.983" "0.991" "0.951" "0.947" "0.994" "0.978" "1556.4" "1566.2" "1582.8" "1543.4" "1529.9" "1543.1" "1479.6" "1473.4" "1547.3" "1521.8" "" "" "" "" "" "" "" "" "" "" "1458.3" "1296.0" "1469.5" "1193.2" "1304.0" "1474.3" "1352.0" "1308.2" "1547.3" "1465.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "170444545631699205" "False" "High" "IsMasterProtein" "Q9Y4E1" "WASH complex subunit 2C OS=Homo sapiens OX=9606 GN=WASHC2C PE=1 SV=5" "0.000" "False" "52.416" "16" "16" "20" "1" "1341" "147.1" "4.81" "59.61" "16" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15255" "253725" "ENSG00000172661" "WASHC2C" "A0A096LPC5; B4DZQ6; B9EK53; F5H0J6; F5H871; hsa:253725; Q5SQU4; Q5SQU5; Q7L521; Q9UG79; Q9Y4E1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200179838073860903" "False" "High" "IsMasterProtein" "O76031" "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial OS=Homo sapiens OX=9606 GN=CLPX PE=1 SV=2" "0.000" "False" "52.285" "27" "16" "19" "16" "633" "69.2" "7.58" "66.34" "16" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf07724, Pf10431" "10845" "ENSG00000166855" "CLPX" "A1L428; A8K8F1; B9EGI8; hsa:10845; O76031; Q9H4D9" "" "Mitochondrial protein degradation" "1" "0" "1.059" "1.124" "1.059" "1.146" "1.148" "1.073" "1.082" "1.080" "1.103" "1770.6" "1875.6" "1990.7" "1875.9" "2029.0" "2033.0" "1899.9" "1915.4" "1912.7" "1953.4" "" "" "" "" "" "" "" "" "" "" "1659.0" "1552.0" "1848.1" "1450.2" "1729.5" "1942.4" "1736.0" "1700.6" "1912.7" "1880.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-681400762000750361" "False" "High" "IsMasterProtein" "O60749" "Sorting nexin-2 OS=Homo sapiens OX=9606 GN=SNX2 PE=1 SV=2" "0.000" "False" "52.283" "29" "12" "19" "10" "519" "58.4" "5.12" "67.29" "12" "cell organization and biogenesis;transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf03700, Pf09325" "6643" "ENSG00000205302" "SNX2" "B3KN44; B4DEK4; B7Z408; hsa:6643; O43650; O60749; P82862; Q53XK8; Q597H6; Q9BTS8" "" "Golgi Associated Vesicle Biogenesis" "1" "2" "0.980" "1.030" "0.972" "1.007" "1.020" "0.989" "1.006" "1.029" "1.002" "2407.4" "2360.1" "2480.2" "2340.3" "2424.2" "2456.8" "2380.5" "2423.0" "2477.4" "2411.0" "" "" "" "" "" "" "" "" "" "" "2255.7" "1953.0" "2302.5" "1809.1" "2066.3" "2347.2" "2175.1" "2151.3" "2477.4" "2321.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-374289036912732411" "False" "High" "IsMasterProtein" "Q15042" "Rab3 GTPase-activating protein catalytic subunit OS=Homo sapiens OX=9606 GN=RAB3GAP1 PE=1 SV=3" "0.000" "False" "52.276" "18" "18" "20" "18" "981" "110.5" "5.55" "59.84" "18" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf13890, Pf19533" "22930" "ENSG00000115839" "RAB3GAP1" "A6H8Z3; C9J837; hsa:22930; Q15042; Q659F5; Q8TBB4" "" "RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic" "2" "0" "1.012" "1.013" "0.939" "1.000" "1.005" "0.937" "0.958" "0.983" "1.031" "3042.1" "3078.6" "3081.2" "2855.3" "3042.1" "3057.6" "2849.9" "2915.5" "2991.7" "3136.6" "" "" "" "" "" "" "" "" "" "" "2850.4" "2547.5" "2860.5" "2207.3" "2593.0" "2921.2" "2604.0" "2588.7" "2991.7" "3020.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1796554414882976290" "False" "High" "IsMasterProtein" "Q8TCG1" "Protein CIP2A OS=Homo sapiens OX=9606 GN=CIP2A PE=1 SV=2" "0.000" "False" "52.234" "17" "18" "20" "18" "905" "102.1" "6.23" "66.39" "18" "cell organization and biogenesis;stress response" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf21044" "57650" "ENSG00000163507" "CIP2A" "A1L4J7; B9EGC3; hsa:57650; Q6P4G6; Q8TCG1; Q8WVP8; Q96PI2; Q9H9C6; Q9P204" "Netrin-UNC5B signaling pathway" "" "1" "0" "0.963" "0.964" "0.957" "0.966" "0.959" "0.925" "0.923" "0.905" "0.975" "4386.6" "4226.5" "4227.2" "4196.8" "4237.1" "4206.6" "4056.8" "4049.8" "3968.2" "4276.5" "" "" "" "" "" "" "" "" "" "" "4110.2" "3497.3" "3924.4" "3244.4" "3611.6" "4019.0" "3706.8" "3595.8" "3968.2" "4117.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5794386193398091018" "False" "High" "IsMasterProtein" "Q9NY33" "Dipeptidyl peptidase 3 OS=Homo sapiens OX=9606 GN=DPP3 PE=1 SV=2" "0.000" "False" "52.234" "26" "17" "25" "17" "737" "82.5" "5.10" "81.70" "17" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf03571" "10072" "ENSG00000254986" "DPP3" "B2RDB5; B4DLX4; F5H8L6; hsa:10072; O95748; Q969H2; Q9BV67; Q9HAL6; Q9NY33" "" "Neddylation; KEAP1-NFE2L2 pathway" "2" "0" "0.965" "0.987" "0.953" "0.967" "0.952" "0.920" "0.954" "0.938" "0.963" "2835.2" "2736.0" "2797.5" "2701.7" "2740.5" "2699.6" "2607.4" "2703.4" "2660.3" "2730.5" "" "" "" "" "" "" "" "" "" "" "2656.6" "2264.0" "2597.1" "2088.6" "2335.9" "2579.2" "2382.5" "2400.3" "2660.3" "2629.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5760728246443025630" "False" "High" "IsMasterProtein" "Q99707" "Methionine synthase OS=Homo sapiens OX=9606 GN=MTR PE=1 SV=2" "0.000" "False" "52.087" "14" "18" "21" "18" "1265" "140.4" "5.58" "57.94" "18" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00809, Pf02310, Pf02574, Pf02607, Pf02965" "4548" "ENSG00000116984" "MTR" "A1L4N8; A9Z1W4; B7ZLW7; B9EGF7; hsa:4548; Q99707; Q99713; Q99723" "Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Folate metabolism; Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Vitamin B12 disorders; Male infertility; Spina bifida" "RHOH GTPase cycle; Methylation; Cobalamin (Cbl) metabolism; Sulfur amino acid metabolism; Defective MTRR causes HMAE; Defective MTR causes HMAG" "19" "0" "1.028" "1.027" "1.053" "1.030" "1.027" "0.926" "0.952" "0.937" "1.031" "2122.7" "2181.3" "2181.0" "2234.3" "2187.2" "2180.7" "1966.1" "2020.5" "1988.9" "2187.6" "" "" "" "" "" "" "" "" "" "" "1989.0" "1805.0" "2024.8" "1727.2" "1864.3" "2083.5" "1796.5" "1794.0" "1988.9" "2106.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3977231737757699064" "False" "High" "IsMasterProtein" "Q6JBY9" "CapZ-interacting protein OS=Homo sapiens OX=9606 GN=RCSD1 PE=1 SV=1" "0.000" "False" "52.041" "43" "16" "32" "16" "416" "44.5" "5.40" "109.05" "16" "stress response;transport;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf05177, Pf15255" "92241" "ENSG00000198771" "RCSD1" "B1AK48; hsa:92241; Q4G0E7; Q6IN93; Q6JBY9; Q8IZM2; Q96DX0; Q9NST4" "" "" "0" "0" "1.170" "1.011" "0.971" "0.955" "0.936" "0.910" "0.959" "0.963" "0.936" "4179.4" "4889.8" "4225.9" "4058.2" "3990.7" "3913.1" "3801.1" "4009.0" "4024.3" "3912.4" "" "" "" "" "" "" "" "" "" "" "3916.0" "4046.3" "3923.2" "3137.2" "3401.6" "3738.6" "3473.2" "3559.6" "4024.3" "3767.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6920554993800994285" "False" "High" "IsMasterProtein" "Q02880" "DNA topoisomerase 2-beta OS=Homo sapiens OX=9606 GN=TOP2B PE=1 SV=3" "0.000" "False" "51.926" "10" "17" "23" "11" "1626" "183.2" "8.00" "65.37" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00204, Pf00521, Pf01751, Pf02518, Pf08070, Pf16898" "7155" "ENSG00000077097" "TOP2B" "hsa:7155; Q02880; Q13600; Q9UMG8; Q9UQP8" "" "SUMOylation of DNA replication proteins" "1" "6" "0.985" "0.999" "1.034" "1.090" "1.034" "1.185" "1.248" "1.250" "1.130" "3164.2" "3115.9" "3160.4" "3270.3" "3447.5" "3270.9" "3748.8" "3949.4" "3955.2" "3574.1" "" "" "" "" "" "" "" "" "" "" "2964.9" "2578.4" "2934.0" "2528.1" "2938.6" "3125.0" "3425.4" "3506.7" "3955.2" "3441.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8321925279742634811" "False" "High" "IsMasterProtein" "Q9Y6Y8" "SEC23-interacting protein OS=Homo sapiens OX=9606 GN=SEC23IP PE=1 SV=1" "0.000" "False" "51.919" "20" "19" "23" "18" "1000" "111.0" "5.54" "64.25" "19" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00536, Pf02825, Pf02862" "11196" "ENSG00000107651" "SEC23IP" "D3DRD2; hsa:11196; Q8IXH5; Q9BUK5; Q9Y6Y8" "" "COPII-mediated vesicle transport" "1" "1" "1.028" "1.009" "0.969" "0.962" "0.953" "0.891" "0.936" "0.952" "0.977" "2478.8" "2548.8" "2500.8" "2401.4" "2383.9" "2362.0" "2207.6" "2319.8" "2358.6" "2422.2" "" "" "" "" "" "" "" "" "" "" "2322.6" "2109.1" "2321.7" "1856.4" "2032.0" "2256.7" "2017.2" "2059.8" "2358.6" "2332.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-719373628240286726" "False" "High" "IsMasterProtein" "O00231" "26S proteasome non-ATPase regulatory subunit 11 OS=Homo sapiens OX=9606 GN=PSMD11 PE=1 SV=3" "0.000" "False" "51.908" "37" "15" "25" "15" "422" "47.4" "6.48" "83.76" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01399, Pf18055, Pf18503" "5717" "ENSG00000108671" "PSMD11" "A8K3I7; E1P663; hsa:5717; O00231; O00495; Q53FT5" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling" "Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "1.039" "1.036" "1.018" "1.028" "0.991" "0.984" "0.978" "0.991" "1.009" "2028.8" "2107.2" "2101.6" "2065.3" "2084.7" "2010.3" "1995.5" "1983.7" "2010.3" "2046.7" "" "" "" "" "" "" "" "" "" "" "1900.9" "1743.7" "1951.1" "1596.6" "1776.9" "1920.6" "1823.4" "1761.3" "2010.3" "1970.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5808192534094495875" "False" "High" "IsMasterProtein" "Q9HC35" "Echinoderm microtubule-associated protein-like 4 OS=Homo sapiens OX=9606 GN=EML4 PE=1 SV=3" "0.000" "False" "51.906" "16" "14" "17" "14" "981" "108.8" "6.40" "57.05" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451" "27436" "ENSG00000143924" "EML4" "A6H8Y6; A6P4T4; A6P4V4; B2RBK3; B2RTW7; B5MCW9; hsa:27436; Q3SWW0; Q53R29; Q53TW8; Q6PJ45; Q9HC35; Q9NV40" "Non-small cell lung cancer" "EML4 and NUDC in mitotic spindle formation; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "4" "0" "0.973" "1.001" "0.965" "0.972" "0.965" "0.962" "0.945" "0.956" "0.977" "3145.1" "3060.1" "3147.0" "3036.1" "3058.0" "3036.2" "3025.4" "2970.9" "3007.6" "3071.4" "" "" "" "" "" "" "" "" "" "" "2946.9" "2532.2" "2921.6" "2347.0" "2606.6" "2900.8" "2764.4" "2637.9" "3007.6" "2957.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-729542664091126034" "False" "High" "IsMasterProtein" "Q93008" "Ubiquitin carboxyl-terminal hydrolase 9X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=4" "0.000" "False" "51.829" "7" "18" "19" "18" "2554" "290.3" "5.80" "54.19" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00443, Pf12030" "8239" "ENSG00000124486" "USP9X" "hsa:8239; O75550; Q8WWT3; Q8WX12; Q93008" "Ciliopathies; Bardet-Biedl syndrome" "Ub-specific processing proteases; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Amyloid fiber formation; Peroxisomal protein import; RHOV GTPase cycle; RHOU GTPase cycle; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "9" "0" "0.951" "0.989" "0.981" "0.968" "0.985" "0.966" "0.960" "0.958" "0.964" "2290.5" "2177.6" "2264.5" "2247.8" "2216.3" "2257.2" "2212.6" "2197.9" "2193.4" "2208.5" "" "" "" "" "" "" "" "" "" "" "2146.2" "1801.9" "2102.3" "1737.6" "1889.1" "2156.6" "2021.7" "1951.6" "2193.4" "2126.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4642176776796334220" "False" "High" "IsMasterProtein" "P35580" "Myosin-10 OS=Homo sapiens OX=9606 GN=MYH10 PE=1 SV=3" "0.000" "False" "51.827" "8" "17" "24" "6" "1976" "228.9" "5.54" "74.76" "17" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00063, Pf00612, Pf01576, Pf02736" "4628" "ENSG00000133026" "MYH10" "B2RWP9; D3DTS1; F8VTL3; hsa:4628; P35580; Q12989; Q149N3; Q149N4; Q16087; Q4LE45; Q6PK16; Q9BWG0" "Regulation of actin cytoskeleton" "EPHA-mediated growth cone collapse; RHO GTPases activate CIT; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "7" "0" "1.021" "0.948" "1.210" "1.039" "1.041" "0.973" "0.987" "0.977" "1.043" "241.9" "246.9" "229.4" "292.6" "251.4" "251.9" "235.3" "238.7" "236.4" "252.3" "" "" "" "" "" "" "" "" "" "" "226.7" "204.3" "213.0" "226.2" "214.3" "240.6" "215.0" "211.9" "236.4" "242.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5428916693947129614" "False" "High" "IsMasterProtein" "Q92556" "Engulfment and cell motility protein 1 OS=Homo sapiens OX=9606 GN=ELMO1 PE=1 SV=2" "0.000" "False" "51.827" "22" "17" "31" "17" "727" "83.8" "6.28" "98.98" "17" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf04727, Pf11841, Pf16457" "9844" "ENSG00000155849" "ELMO1" "A4D1X6; hsa:9844; Q29R79; Q6ZTJ0; Q92556; Q96PB0; Q9H0I1" "Chemokine signaling pathway; CCL18 signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Nef and signal transduction" "7" "0" "0.961" "1.002" "0.976" "0.950" "0.979" "0.934" "0.963" "0.997" "0.979" "4232.2" "4067.0" "4240.3" "4132.4" "4022.4" "4142.3" "3952.9" "4076.2" "4219.5" "4141.7" "" "" "" "" "" "" "" "" "" "" "3965.6" "3365.4" "3936.6" "3194.5" "3428.6" "3957.6" "3611.9" "3619.2" "4219.5" "3987.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1748573463469303870" "False" "High" "IsMasterProtein" "Q99661" "Kinesin-like protein KIF2C OS=Homo sapiens OX=9606 GN=KIF2C PE=1 SV=2" "0.000" "False" "51.806" "25" "15" "18" "13" "725" "81.3" "7.83" "63.79" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00225" "11004" "ENSG00000142945" "KIF2C" "B3ITR9; hsa:11004; Q5JR88; Q6ICU1; Q96C18; Q96HB8; Q99661; Q9BWV8" "Microtubule cytoskeleton regulation" "Resolution of Sister Chromatid Cohesion; MHC class II antigen presentation; RHO GTPases Activate Formins; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "10" "0" "1.033" "1.048" "1.024" "1.048" "0.982" "0.983" "0.965" "0.966" "1.027" "2408.4" "2488.7" "2522.9" "2466.5" "2522.9" "2364.6" "2366.4" "2324.5" "2326.1" "2474.1" "" "" "" "" "" "" "" "" "" "" "2256.7" "2059.3" "2342.2" "1906.7" "2150.4" "2259.1" "2162.2" "2063.9" "2326.1" "2382.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3509050462547548554" "False" "High" "IsMasterProtein" "Q04917" "14-3-3 protein eta OS=Homo sapiens OX=9606 GN=YWHAH PE=1 SV=4" "0.000" "False" "51.802" "50" "12" "57" "8" "246" "28.2" "4.84" "146.89" "12" "other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00244" "7533" "ENSG00000128245" "YWHAH" "hsa:7533; Q04917" "Cell cycle; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "11" "0" "1.025" "0.966" "0.902" "0.951" "0.989" "0.906" "0.982" "1.016" "0.989" "2112.5" "2165.1" "2040.3" "1905.7" "2009.7" "2089.3" "1913.5" "2073.8" "2145.5" "2088.9" "" "" "" "" "" "" "" "" "" "" "1979.4" "1791.6" "1894.1" "1473.2" "1713.0" "1996.1" "1748.4" "1841.3" "2145.5" "2011.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1739284738644474323" "False" "High" "IsMasterProtein" "P25098" "Beta-adrenergic receptor kinase 1 OS=Homo sapiens OX=9606 GN=GRK2 PE=1 SV=2" "0.000" "False" "51.615" "27" "18" "28" "18" "689" "79.5" "7.28" "84.30" "18" "cell-cell signaling;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00615" "156" "ENSG00000173020" "GRK2" "B0ZBE1; hsa:156; P25098; Q13837; Q6GTT3" "Chemokine signaling pathway; Hedgehog signaling pathway; Hedgehog signaling pathway; HDAC6 interactions in the central nervous system" "G alpha (q) signalling events; Activation of SMO; G alpha (s) signalling events; Cargo recognition for clathrin-mediated endocytosis; Calmodulin induced events" "9" "0" "1.019" "1.014" "0.991" "0.982" "0.990" "1.008" "0.965" "0.966" "0.970" "2055.1" "2095.0" "2084.1" "2037.3" "2018.8" "2033.5" "2071.4" "1982.2" "1985.1" "1993.0" "" "" "" "" "" "" "" "" "" "" "1925.6" "1733.6" "1934.8" "1574.9" "1720.7" "1942.9" "1892.7" "1760.0" "1985.1" "1919.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4532618803689773049" "False" "High" "IsMasterProtein" "P00491" "Purine nucleoside phosphorylase OS=Homo sapiens OX=9606 GN=PNP PE=1 SV=2" "0.000" "False" "51.132" "42" "10" "32" "10" "289" "32.1" "6.95" "100.92" "10" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf01048" "4860" "ENSG00000198805; ENSG00000291814" "PNP" "B2R8S5; D3DS00; hsa:4860; P00491; Q15160; Q5PZ03" "VEGFA-VEGFR2 signaling" "Neutrophil degranulation; Purine catabolism; Ribavirin ADME; Purine salvage; Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine" "6" "0" "1.047" "1.011" "1.099" "1.039" "0.994" "1.063" "1.016" "1.119" "1.036" "1943.2" "2034.1" "1964.5" "2135.9" "2019.4" "1931.1" "2065.5" "1975.2" "2173.6" "2013.9" "" "" "" "" "" "" "" "" "" "" "1820.7" "1683.2" "1823.8" "1651.2" "1721.3" "1844.9" "1887.3" "1753.8" "2173.6" "1939.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4905591351439676835" "False" "High" "IsMasterProtein" "P50995" "Annexin A11 OS=Homo sapiens OX=9606 GN=ANXA11 PE=1 SV=1" "0.000" "False" "51.127" "32" "15" "21" "15" "505" "54.4" "7.65" "73.70" "15" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00191" "311" "ENSG00000122359" "ANXA11" "B4DVE7; hsa:311; P50995" "" "" "0" "0" "1.044" "1.027" "1.078" "1.090" "1.074" "1.100" "1.068" "1.034" "1.043" "1980.7" "2066.9" "2033.5" "2135.9" "2158.3" "2126.8" "2179.5" "2114.5" "2048.5" "2065.3" "" "" "" "" "" "" "" "" "" "" "1855.9" "1710.3" "1887.8" "1651.1" "1839.7" "2031.9" "1991.5" "1877.4" "2048.5" "1988.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2867565850229162791" "False" "High" "IsMasterProtein" "P12081" "Histidine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=HARS1 PE=1 SV=2" "0.000" "False" "51.125" "26" "15" "25" "10" "509" "57.4" "5.88" "82.27" "15" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00458, Pf03129, Pf13393" "3035" "ENSG00000170445" "HARS1" "B4DHQ1; B4DY73; D6REN6; hsa:3035; J3KNE5; P12081" "Allograft rejection" "Cytosolic tRNA aminoacylation" "2" "4" "0.967" "0.950" "1.042" "0.946" "0.916" "0.964" "0.974" "0.908" "0.915" "2917.6" "2821.6" "2771.4" "3040.4" "2761.2" "2672.6" "2813.1" "2841.8" "2648.9" "2671.0" "" "" "" "" "" "" "" "" "" "" "2733.8" "2334.8" "2572.9" "2350.3" "2353.5" "2553.5" "2570.4" "2523.2" "2648.9" "2571.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8364348392468163032" "False" "High" "IsMasterProtein" "P04040" "Catalase OS=Homo sapiens OX=9606 GN=CAT PE=1 SV=3" "0.000" "False" "51.065" "33" "16" "23" "16" "527" "59.7" "7.39" "80.00" "16" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00199, Pf06628" "847" "ENSG00000121691" "CAT" "A8K6C0; B2RCZ9; D3DR07; hsa:847; P04040; Q2M1U4; Q4VXX5; Q9BWT9; Q9UC85" "Selenium micronutrient network; Folate metabolism; Amyotrophic lateral sclerosis (ALS); Oxidative stress response; Tryptophan metabolism; Male infertility; Arsenic metabolism and reactive oxygen species generation; DNA damage response (only ATM dependent)" "Neutrophil degranulation; Peroxisomal protein import; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Detoxification of Reactive Oxygen Species" "12" "0" "1.017" "0.967" "1.057" "1.006" "1.092" "0.960" "0.979" "0.971" "0.977" "3249.4" "3304.6" "3143.4" "3434.4" "3270.5" "3548.9" "3120.5" "3181.5" "3154.9" "3176.0" "" "" "" "" "" "" "" "" "" "" "3044.7" "2734.5" "2918.3" "2654.9" "2787.7" "3390.7" "2851.3" "2824.8" "3154.9" "3058.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "965270540937199853" "False" "High" "IsMasterProtein" "Q14151" "Scaffold attachment factor B2 OS=Homo sapiens OX=9606 GN=SAFB2 PE=1 SV=1" "0.000" "False" "51.010" "18" "18" "19" "12" "953" "107.4" "6.16" "58.28" "18" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02037" "9667" "ENSG00000130254" "SAFB2" "B4DKG3; hsa:9667; Q14151; Q8TB13" "" "" "0" "3" "1.078" "1.077" "1.128" "1.121" "1.100" "1.396" "1.239" "1.310" "1.190" "877.6" "946.4" "945.6" "989.9" "983.7" "965.4" "1225.2" "1086.9" "1149.7" "1044.4" "" "" "" "" "" "" "" "" "" "" "822.3" "783.1" "877.8" "765.2" "838.5" "922.4" "1119.5" "965.1" "1149.7" "1005.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3820767575237366491" "False" "High" "IsMasterProtein" "Q9HAU5" "Regulator of nonsense transcripts 2 OS=Homo sapiens OX=9606 GN=UPF2 PE=1 SV=1" "0.000" "False" "50.679" "14" "19" "20" "19" "1272" "147.7" "5.69" "65.21" "19" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02854, Pf04050" "26019" "ENSG00000151461" "UPF2" "A6NLJ5; D3DRS0; hsa:26019; Q14BM1; Q5W0J4; Q8N8U1; Q9H1J2; Q9HAU5; Q9NWL1; Q9P2D9; Q9Y4M9" "" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "2" "0" "0.977" "1.042" "1.050" "1.031" "1.028" "1.014" "0.995" "1.013" "1.042" "2156.1" "2106.5" "2246.6" "2264.7" "2223.2" "2217.4" "2186.3" "2146.0" "2184.8" "2246.2" "" "" "" "" "" "" "" "" "" "" "2020.3" "1743.1" "2085.7" "1750.7" "1895.0" "2118.5" "1997.7" "1905.4" "2184.8" "2162.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8359022296663299879" "False" "High" "IsMasterProtein" "Q14258" "E3 ubiquitin/ISG15 ligase TRIM25 OS=Homo sapiens OX=9606 GN=TRIM25 PE=1 SV=2" "0.000" "False" "50.666" "22" "15" "21" "15" "630" "70.9" "8.09" "73.42" "15" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00622, Pf13445, Pf13765" "7706" "ENSG00000121060" "TRIM25" "hsa:7706; Q14258" "Novel intracellular components of RIG-I-like receptor pathway; Cytosolic DNA-sensing pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; 1p36 copy number variation syndrome" "SARS-CoV-1 activates/modulates innate immune responses; ISG15 antiviral mechanism; Interferon gamma signaling; RSV-host interactions; PKR-mediated signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses" "19" "0" "0.952" "0.982" "0.920" "0.947" "0.970" "0.883" "0.925" "0.911" "0.951" "2884.5" "2746.0" "2831.5" "2652.5" "2732.8" "2796.9" "2546.4" "2666.9" "2628.5" "2744.1" "" "" "" "" "" "" "" "" "" "" "2702.7" "2272.3" "2628.7" "2050.5" "2329.4" "2672.2" "2326.7" "2368.0" "2628.5" "2642.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1054050603788689952" "False" "High" "IsMasterProtein" "Q86YV0" "RAS protein activator like-3 OS=Homo sapiens OX=9606 GN=RASAL3 PE=1 SV=2" "0.000" "False" "50.635" "17" "16" "19" "16" "1011" "111.8" "8.75" "64.66" "16" "other biological processes" "other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00616" "64926" "ENSG00000105122" "RASAL3" "hsa:64926; Q86YV0; Q8N2T9; Q9H735" "Ras signaling" "Regulation of RAS by GAPs" "2" "0" "1.023" "1.001" "1.047" "1.034" "1.022" "0.975" "0.926" "0.937" "0.979" "2157.9" "2208.2" "2160.3" "2259.7" "2230.9" "2205.2" "2103.8" "1998.8" "2022.7" "2113.6" "" "" "" "" "" "" "" "" "" "" "2022.0" "1827.2" "2005.6" "1746.9" "1901.5" "2106.8" "1922.3" "1774.7" "2022.7" "2035.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2580326738670543746" "False" "High" "IsMasterProtein" "O60341" "Lysine-specific histone demethylase 1A OS=Homo sapiens OX=9606 GN=KDM1A PE=1 SV=2" "0.000" "False" "50.561" "19" "15" "20" "15" "852" "92.8" "6.52" "58.83" "15" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01593, Pf04433" "23028" "ENSG00000004487" "KDM1A" "A8MWP9; hsa:23028; O60341; Q5TH94; Q5TH95; Q86VT7; Q8IXK4; Q8NDP6; Q8TAZ3; Q96AW4" "Androgen receptor signaling pathway; Effect of progerin on genes involved in progeria; Thermogenesis; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Neurogenesis regulation in the olfactory epithelium" "Estrogen-dependent gene expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3" "14" "0" "0.963" "1.029" "0.937" "1.012" "1.022" "0.969" "1.003" "1.029" "1.024" "2017.5" "1941.9" "2076.6" "1891.1" "2042.6" "2062.7" "1955.8" "2023.3" "2076.4" "2065.2" "" "" "" "" "" "" "" "" "" "" "1890.4" "1606.9" "1927.8" "1461.9" "1741.0" "1970.7" "1787.1" "1796.5" "2076.4" "1988.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6681537936157474887" "False" "High" "IsMasterProtein" "Q9UH65" "Switch-associated protein 70 OS=Homo sapiens OX=9606 GN=SWAP70 PE=1 SV=1" "0.000" "False" "50.494" "23" "16" "22" "15" "585" "69.0" "5.87" "68.08" "16" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00169" "23075" "ENSG00000133789" "SWAP70" "D3DQV1; hsa:23075; O75135; Q7LCY6; Q9P061; Q9P0Z8; Q9UH65" "" "RAC1 GTPase cycle; RAC3 GTPase cycle; RAC2 GTPase cycle" "3" "1" "0.935" "0.962" "0.927" "0.944" "0.957" "0.942" "0.944" "0.944" "0.945" "3422.6" "3199.1" "3291.5" "3174.3" "3232.1" "3276.5" "3224.3" "3229.5" "3230.6" "3235.9" "" "" "" "" "" "" "" "" "" "" "3207.0" "2647.2" "3055.8" "2453.9" "2755.0" "3130.4" "2946.2" "2867.4" "3230.6" "3115.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5365621191326057651" "False" "High" "IsMasterProtein" "P54819" "Adenylate kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=AK2 PE=1 SV=2" "0.000" "False" "50.461" "54" "12" "35" "12" "239" "26.5" "7.81" "106.35" "12" "other metabolic processes" "cytoskeleton;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "204" "ENSG00000004455" "AK2" "A8K6L1; B4DHH7; B4DL64; hsa:204; P54819; Q16856; Q5EB54; Q5TIF7; Q8TCY2; Q8TCY3" "" "Interconversion of nucleotide di- and triphosphates" "1" "0" "1.107" "0.983" "1.024" "1.046" "1.002" "1.005" "1.011" "1.048" "1.002" "3691.2" "4086.4" "3629.3" "3780.9" "3862.0" "3699.4" "3709.7" "3730.4" "3868.7" "3697.4" "" "" "" "" "" "" "" "" "" "" "3458.7" "3381.5" "3369.3" "2922.8" "3291.8" "3534.5" "3389.7" "3312.2" "3868.7" "3560.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8320203953169685442" "False" "High" "IsMasterProtein" "Q9NZL9" "Methionine adenosyltransferase 2 subunit beta OS=Homo sapiens OX=9606 GN=MAT2B PE=1 SV=1" "0.000" "False" "50.410" "48" "14" "24" "14" "334" "37.5" "7.36" "81.08" "14" "other metabolic processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04321" "27430" "ENSG00000038274" "MAT2B" "B2R5Y6; hsa:27430; Q1WAI7; Q27J92; Q3LIE8; Q567T7; Q6NYC7; Q9BS89; Q9H3E1; Q9NZL9; Q9UJ54" "Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; Spina bifida; Methylation pathways" "Ub-specific processing proteases; Methylation" "8" "0" "0.979" "0.969" "1.015" "1.001" "0.988" "0.987" "1.002" "0.991" "0.987" "2430.3" "2380.4" "2355.6" "2466.3" "2431.9" "2402.3" "2399.2" "2434.9" "2408.5" "2397.7" "" "" "" "" "" "" "" "" "" "" "2277.2" "1969.8" "2186.9" "1906.6" "2072.9" "2295.1" "2192.3" "2161.9" "2408.5" "2308.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2887047081584333281" "False" "High" "IsMasterProtein" "P54652" "Heat shock-related 70 kDa protein 2 OS=Homo sapiens OX=9606 GN=HSPA2 PE=1 SV=1" "0.000" "False" "50.410" "18" "14" "70" "1" "639" "70.0" "5.74" "236.61" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00012" "3306" "ENSG00000126803" "HSPA2" "hsa:3306; P54652; Q15508; Q53XM3; Q9UE78" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Measles virus infection; 7q11.23 copy number variation syndrome; Urotensin-II-mediated signaling pathway" "Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Meiotic synapsis; Attenuation phase" "10" "0" "0.811" "0.972" "0.840" "0.858" "0.976" "0.856" "1.137" "0.876" "0.990" "912.0" "739.6" "886.1" "765.8" "782.6" "890.3" "780.3" "1036.6" "799.3" "902.5" "" "" "" "" "" "" "" "" "" "" "854.5" "612.0" "822.6" "592.0" "667.1" "850.6" "713.0" "920.4" "799.3" "869.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6965600281876429507" "False" "High" "IsMasterProtein" "P46063" "ATP-dependent DNA helicase Q1 OS=Homo sapiens OX=9606 GN=RECQL PE=1 SV=3" "0.000" "False" "50.343" "26" "16" "25" "15" "649" "73.4" "7.88" "70.65" "16" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf16124" "5965" "ENSG00000004700" "RECQL" "A8K6G2; P46063" "Progeria-associated lipodystrophy" "" "1" "1" "0.956" "0.970" "0.962" "0.957" "0.967" "0.976" "0.974" "0.976" "0.954" "2993.6" "2860.5" "2904.8" "2879.2" "2865.4" "2896.0" "2921.7" "2916.1" "2920.5" "2855.4" "" "" "" "" "" "" "" "" "" "" "2805.0" "2367.0" "2696.7" "2225.7" "2442.4" "2766.8" "2669.6" "2589.2" "2920.5" "2749.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6826541305752528518" "False" "High" "IsMasterProtein" "P23381" "Tryptophan--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=WARS1 PE=1 SV=2" "0.000" "False" "50.270" "32" "14" "29" "14" "471" "53.1" "6.23" "82.69" "14" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00458, Pf00579" "7453" "ENSG00000140105" "WARS1" "A6NGN1; A6NID3; hsa:7453; P23381; P78535; Q502Y0; Q53XB6; Q9UDI5; Q9UDL3" "Photodynamic therapy-induced unfolded protein response; Amino acid metabolism" "Cytosolic tRNA aminoacylation" "3" "0" "0.927" "0.991" "0.919" "0.924" "0.965" "0.928" "0.943" "0.919" "0.925" "3465.4" "3213.2" "3434.5" "3183.2" "3202.5" "3343.7" "3217.2" "3267.1" "3184.0" "3204.3" "" "" "" "" "" "" "" "" "" "" "3247.1" "2658.9" "3188.5" "2460.8" "2729.7" "3194.6" "2939.7" "2900.9" "3184.0" "3085.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1302469806401564563" "False" "High" "IsMasterProtein" "P49748" "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADVL PE=1 SV=1" "0.000" "False" "50.262" "25" "14" "18" "14" "655" "70.3" "8.75" "62.47" "14" "other metabolic processes;stress response;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00441, Pf02770, Pf02771, Pf21343" "37" "ENSG00000072778" "ACADVL" "B4DEB6; F5H2A9; hsa:37; O76056; P49748; Q8WUL0" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation" "XBP1(S) activates chaperone genes; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "4" "0" "1.016" "1.031" "1.002" "1.060" "1.033" "0.984" "0.978" "1.014" "0.995" "1572.9" "1597.6" "1621.9" "1576.8" "1668.0" "1624.4" "1547.4" "1537.9" "1595.2" "1564.4" "" "" "" "" "" "" "" "" "" "" "1473.8" "1322.0" "1505.7" "1219.0" "1421.7" "1552.0" "1413.9" "1365.5" "1595.2" "1506.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3549742544018315320" "False" "High" "IsMasterProtein" "O14744" "Protein arginine N-methyltransferase 5 OS=Homo sapiens OX=9606 GN=PRMT5 PE=1 SV=4" "0.000" "False" "50.249" "30" "17" "33" "17" "637" "72.6" "6.29" "93.32" "17" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05185, Pf17285, Pf17286" "10419" "ENSG00000100462" "PRMT5" "A8MTP3; A8MZ91; B4DX49; B4DY30; B5BU10; D3DS33; E2QRE7; hsa:10419; O14744; Q6IBR1; Q9UKH1" "Transcription co-factors SKI and SKIL protein partners; Nitric oxide metabolism in cystic fibrosis" "snRNP Assembly; RMTs methylate histone arginines; Regulation of TP53 Activity through Methylation" "5" "0" "0.973" "1.004" "0.994" "0.986" "0.990" "1.000" "1.016" "1.013" "0.977" "2950.3" "2871.0" "2962.5" "2932.5" "2908.6" "2920.3" "2950.9" "2996.4" "2989.3" "2883.4" "" "" "" "" "" "" "" "" "" "" "2764.4" "2375.8" "2750.3" "2267.0" "2479.2" "2790.1" "2696.3" "2660.5" "2989.3" "2776.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4459435427997336669" "False" "High" "IsMasterProtein" "O60231" "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 OS=Homo sapiens OX=9606 GN=DHX16 PE=1 SV=2" "0.000" "False" "50.191" "18" "16" "21" "16" "1041" "119.2" "6.80" "66.10" "16" "RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "8449" "ENSG00000204560; ENSG00000206486; ENSG00000226171; ENSG00000231377; ENSG00000233049; ENSG00000233418; ENSG00000233561" "DHX16" "hsa:8449; O60231; O60322; Q5JP45; Q969X7; Q96QC1" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.267" "1.029" "1.125" "1.126" "1.166" "1.141" "1.053" "1.238" "1.142" "2398.4" "3038.3" "2468.2" "2697.1" "2699.6" "2797.4" "2737.7" "2526.7" "2970.0" "2738.8" "" "" "" "" "" "" "" "" "" "" "2247.3" "2514.2" "2291.4" "2085.0" "2301.1" "2672.7" "2501.5" "2243.4" "2970.0" "2637.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2832146552711634492" "False" "High" "IsMasterProtein" "Q02218" "2-oxoglutarate dehydrogenase complex component E1 OS=Homo sapiens OX=9606 GN=OGDH PE=1 SV=3" "0.000" "False" "50.064" "16" "15" "22" "15" "1023" "115.9" "6.86" "72.37" "15" "protein metabolism;other metabolic processes;developmental processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00676, Pf02779, Pf16078, Pf16870" "4967" "ENSG00000105953" "OGDH" "B4E2U9; D3DVL0; E9PBM1; hsa:4967; Q02218; Q96DD3; Q9UDX0" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Thiamine metabolic pathways; 7q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)" "Lysine catabolism; Glyoxylate metabolism and glycine degradation; Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "9" "0" "1.044" "1.048" "1.021" "1.059" "1.082" "1.004" "1.030" "1.030" "1.009" "2842.3" "2968.7" "2979.3" "2900.9" "3010.0" "3074.6" "2854.1" "2928.2" "2926.6" "2867.8" "" "" "" "" "" "" "" "" "" "" "2663.2" "2456.6" "2765.9" "2242.5" "2565.6" "2937.5" "2607.9" "2600.0" "2926.6" "2761.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4669002677123591675" "False" "High" "IsMasterProtein" "P06493" "Cyclin-dependent kinase 1 OS=Homo sapiens OX=9606 GN=CDK1 PE=1 SV=3" "0.000" "False" "49.931" "46" "12" "24" "10" "297" "34.1" "8.40" "79.00" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "983" "ENSG00000170312" "CDK1" "A8K7C4; C9J497; hsa:983; O60764; P06493" "miRNA regulation of DNA damage response; Cell cycle; Microtubule cytoskeleton regulation; Spinal cord injury; Retinoblastoma gene in cancer; ATM signaling pathway; PPAR-alpha pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; G1 to S cell cycle control; Cohesin complex - Cornelia de Lange syndrome; Urotensin-II-mediated signaling pathway; DNA damage response" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; PKR-mediated signaling; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of TP53 Degradation; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of the APC/C; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Transcriptional regulation by RUNX2; Ovarian tumor domain proteases; MASTL Facilitates Mitotic Progression; E2F-enabled inhibition of pre-replication complex formation; MAPK3 (ERK1) activation; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; G1/S-Specific Transcription; Initiation of Nuclear Envelope (NE) Reformation; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Depolymerization of the Nuclear Lamina; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes; Phosphorylation of Emi1" "50" "1" "0.967" "0.976" "0.953" "0.955" "0.933" "0.895" "0.889" "0.944" "0.982" "3311.0" "3201.0" "3231.6" "3157.0" "3163.5" "3089.8" "2963.2" "2943.1" "3125.3" "3249.9" "" "" "" "" "" "" "" "" "" "" "3102.4" "2648.8" "3000.1" "2440.5" "2696.5" "2952.0" "2707.6" "2613.2" "3125.3" "3129.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1964393919908826502" "False" "High" "IsMasterProtein" "Q96I99" "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG2 PE=1 SV=2" "0.000" "False" "49.823" "38" "16" "24" "15" "432" "46.5" "6.39" "73.93" "16" "other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf00549, Pf08442" "8801" "ENSG00000172340" "SUCLG2" "C9JVT2; hsa:8801; O95195; Q6NUH7; Q86VX8; Q8WUQ1; Q96I99" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Metabolic reprogramming in colon cancer; TCA cycle (aka Krebs or citric acid cycle)" "Mitochondrial protein degradation; Citric acid cycle (TCA cycle)" "5" "1" "0.949" "0.955" "0.921" "0.948" "0.981" "0.909" "0.926" "0.925" "0.933" "3458.3" "3283.2" "3302.1" "3186.4" "3278.6" "3394.2" "3143.7" "3201.6" "3200.5" "3228.2" "" "" "" "" "" "" "" "" "" "" "3240.5" "2716.8" "3065.6" "2463.2" "2794.6" "3242.9" "2872.5" "2842.7" "3200.5" "3108.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "92619424180281671" "False" "High" "IsMasterProtein" "Q14141" "Septin-6 OS=Homo sapiens OX=9606 GN=SEPTIN6 PE=1 SV=4" "0.000" "False" "49.815" "36" "13" "24" "6" "434" "49.7" "6.67" "75.06" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "23157" "ENSG00000125354" "SEPTIN6" "hsa:23157; Q14141; Q5JTK0; Q969W5; Q96A13; Q96GR1; Q96P86; Q96P87" "2q37 copy number variation syndrome" "" "1" "4" "1.064" "1.036" "1.042" "1.059" "1.043" "0.967" "1.005" "1.047" "1.048" "1624.5" "1728.3" "1682.6" "1692.4" "1721.1" "1694.5" "1571.6" "1632.4" "1700.7" "1703.0" "" "" "" "" "" "" "" "" "" "" "1522.2" "1430.1" "1562.1" "1308.3" "1467.0" "1618.9" "1436.1" "1449.4" "1700.7" "1639.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6088825967158896660" "False" "High" "IsMasterProtein" "O43290" "U4/U6.U5 tri-snRNP-associated protein 1 OS=Homo sapiens OX=9606 GN=SART1 PE=1 SV=1" "0.000" "False" "49.735" "23" "15" "18" "15" "800" "90.2" "6.13" "65.68" "15" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf03343, Pf19252" "9092" "ENSG00000175467" "SART1" "A6NDN1; hsa:9092; O43290; Q53GB5" "" "mRNA Splicing - Major Pathway" "1" "0" "1.030" "1.087" "1.140" "1.135" "1.068" "1.244" "1.280" "1.206" "1.110" "2589.3" "2666.3" "2815.0" "2952.1" "2938.9" "2764.9" "3221.5" "3313.3" "3122.5" "2874.8" "" "" "" "" "" "" "" "" "" "" "2426.1" "2206.4" "2613.4" "2282.1" "2505.0" "2641.6" "2943.6" "2941.9" "3122.5" "2768.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6979633451004201219" "False" "High" "IsMasterProtein" "P31946" "14-3-3 protein beta/alpha OS=Homo sapiens OX=9606 GN=YWHAB PE=1 SV=3" "0.000" "False" "49.644" "61" "13" "71" "6" "246" "28.1" "4.83" "166.09" "13" "signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00244" "7529" "ENSG00000166913" "YWHAB" "A8K9K2; E1P616; hsa:7529; P31946" "Cell cycle; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Hepatitis B infection; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Regulation of localization of FOXO transcription factors; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Signaling by Hippo; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Rap1 signalling; Negative regulation of MAPK pathway; Frs2-mediated activation; ARMS-mediated activation; Activation of BAD and translocation to mitochondria ; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "33" "0" "1.136" "1.041" "0.937" "1.026" "1.046" "0.969" "1.030" "1.091" "1.015" "768.6" "873.2" "799.9" "719.9" "788.9" "803.9" "744.8" "791.5" "838.4" "780.3" "" "" "" "" "" "" "" "" "" "" "720.2" "722.5" "742.6" "556.5" "672.5" "768.0" "680.5" "702.7" "838.4" "751.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5468069501493151827" "False" "High" "IsMasterProtein" "P37837" "Transaldolase OS=Homo sapiens OX=9606 GN=TALDO1 PE=1 SV=2" "0.000" "False" "49.559" "41" "15" "24" "15" "337" "37.5" "6.81" "69.65" "15" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00923" "6888" "ENSG00000177156" "TALDO1" "B2R8M2; hsa:6888; O00751; P37837; Q8WV32; Q8WZ45" "Pentose phosphate metabolism; Cori cycle; Metabolic reprogramming in colon cancer" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate; TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P; TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P" "9" "0" "0.958" "0.958" "0.947" "0.925" "0.928" "0.918" "0.968" "0.969" "0.943" "4780.4" "4577.7" "4579.2" "4525.1" "4422.8" "4435.1" "4387.4" "4625.4" "4630.9" "4506.0" "" "" "" "" "" "" "" "" "" "" "4479.2" "3788.0" "4251.2" "3498.1" "3769.9" "4237.3" "4008.9" "4106.9" "4630.9" "4338.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8048199414682788645" "False" "High" "IsMasterProtein" "Q06323" "Proteasome activator complex subunit 1 OS=Homo sapiens OX=9606 GN=PSME1 PE=1 SV=1" "0.000" "False" "49.554" "51" "13" "30" "13" "249" "28.7" "6.02" "88.72" "13" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf02251, Pf02252" "5720" "ENSG00000092010; ENSG00000284916" "PSME1" "A6NJG9; H0YNE3; hsa:5720; Q06323; Q6IBM2; Q9UEF4" "Proteasome degradation" "Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "60" "0" "1.002" "0.897" "0.905" "0.889" "1.011" "0.896" "0.979" "1.052" "0.962" "4053.0" "4059.6" "3637.4" "3669.5" "3601.8" "4097.6" "3633.3" "3968.6" "4264.0" "3900.7" "" "" "" "" "" "" "" "" "" "" "3797.7" "3359.2" "3376.8" "2836.7" "3070.1" "3914.9" "3319.8" "3523.7" "4264.0" "3755.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3259999118554299265" "False" "High" "IsMasterProtein" "Q16181" "Septin-7 OS=Homo sapiens OX=9606 GN=SEPTIN7 PE=1 SV=2" "0.000" "False" "49.506" "30" "13" "39" "12" "437" "50.6" "8.63" "95.95" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00735" "989" "ENSG00000122545" "SEPTIN7" "hsa:989; Q16181; Q52M76; Q6NX50" "" "MAPK6/MAPK4 signaling" "1" "1" "1.019" "0.992" "1.023" "0.987" "0.967" "0.969" "0.957" "0.993" "0.970" "4053.1" "4131.5" "4021.2" "4146.6" "4000.0" "3919.3" "3929.1" "3876.8" "4024.1" "3929.5" "" "" "" "" "" "" "" "" "" "" "3797.7" "3418.8" "3733.2" "3205.5" "3409.5" "3744.5" "3590.2" "3442.2" "4024.1" "3783.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7058356130293402746" "False" "High" "IsMasterProtein" "Q6ZRS2" "Helicase SRCAP OS=Homo sapiens OX=9606 GN=SRCAP PE=1 SV=3" "0.000" "False" "49.485" "5" "16" "17" "16" "3230" "343.3" "5.96" "56.50" "16" "cell organization and biogenesis;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf07529" "10847" "ENSG00000080603" "SRCAP" "B0JZA6; hsa:10847; O15026; Q6ZRS2; Q7Z744; Q9Y5L9" "Pathways affected in adenoid cystic carcinoma" "" "1" "0" "1.004" "0.978" "1.076" "1.054" "0.994" "0.989" "0.944" "0.972" "1.014" "1764.9" "1771.5" "1726.3" "1898.7" "1859.7" "1754.5" "1745.2" "1666.6" "1715.1" "1789.7" "" "" "" "" "" "" "" "" "" "" "1653.7" "1465.9" "1602.7" "1467.8" "1585.1" "1676.3" "1594.6" "1479.7" "1715.1" "1723.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7835862942369075388" "False" "High" "IsMasterProtein" "P06753" "Tropomyosin alpha-3 chain OS=Homo sapiens OX=9606 GN=TPM3 PE=1 SV=2" "0.000" "False" "49.443" "39" "14" "39" "4" "285" "32.9" "4.72" "113.58" "14" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf00261" "7170" "ENSG00000143549" "TPM3" "D3DV71; hsa:7170; P06753; P12324; Q2QD06; Q5VU58; Q5VU63; Q5VU66; Q5VU71; Q5VU72; Q8TCG3; Q969Q2; Q9NQH8" "Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Striated muscle contraction pathway; VEGFA-VEGFR2 signaling" "RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; Smooth Muscle Contraction; Striated Muscle Contraction" "7" "0" "1.087" "1.047" "1.119" "1.068" "1.052" "1.068" "1.006" "0.990" "1.039" "1067.6" "1161.0" "1117.9" "1194.2" "1140.7" "1123.0" "1140.2" "1074.1" "1056.7" "1108.9" "" "" "" "" "" "" "" "" "" "" "1000.4" "960.7" "1037.8" "923.2" "972.3" "1072.9" "1041.8" "953.7" "1056.7" "1067.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1141422113329583141" "False" "High" "IsMasterProtein" "Q04446" "1,4-alpha-glucan-branching enzyme OS=Homo sapiens OX=9606 GN=GBE1 PE=1 SV=3" "0.000" "False" "49.399" "24" "17" "24" "17" "702" "80.4" "6.32" "71.10" "17" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00128, Pf02806, Pf02922" "2632" "ENSG00000114480" "GBE1" "B3KWV3; hsa:2632; Q04446; Q96EN0" "Glycogen synthesis and degradation; Disorders of galactose metabolism" "Glycogen synthesis; Glycogen storage disease type IV (GBE1)" "4" "0" "0.897" "0.950" "0.875" "0.915" "0.942" "0.906" "0.961" "0.959" "0.950" "2128.4" "1908.6" "2022.8" "1862.5" "1948.1" "2005.9" "1928.5" "2045.4" "2041.7" "2021.7" "" "" "" "" "" "" "" "" "" "" "1994.3" "1579.4" "1877.9" "1439.8" "1660.5" "1916.5" "1762.2" "1816.1" "2041.7" "1946.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5852345656663566721" "False" "High" "IsMasterProtein" "Q5JSL3" "Dedicator of cytokinesis protein 11 OS=Homo sapiens OX=9606 GN=DOCK11 PE=1 SV=2" "0.000" "False" "49.394" "9" "19" "21" "19" "2073" "237.5" "7.74" "67.86" "19" "signal transduction;other biological processes" "cytosol" "enzyme regulator activity;other molecular function" "Pf00169, Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "139818" "ENSG00000147251" "DOCK11" "A6NMF0; hsa:139818; Q5JSL3; Q66M66; Q6ZUJ5; Q86VU8; Q96MN3" "" "Factors involved in megakaryocyte development and platelet production; CDC42 GTPase cycle; RAC1 GTPase cycle" "3" "0" "0.981" "1.005" "1.010" "1.001" "1.002" "0.996" "0.979" "1.029" "1.032" "2358.9" "2314.0" "2370.7" "2382.1" "2361.5" "2363.2" "2349.7" "2310.6" "2427.0" "2435.4" "" "" "" "" "" "" "" "" "" "" "2210.3" "1914.8" "2200.9" "1841.5" "2012.8" "2257.8" "2147.0" "2051.5" "2427.0" "2345.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2531564844693564972" "False" "High" "IsMasterProtein" "O75475" "PC4 and SFRS1-interacting protein OS=Homo sapiens OX=9606 GN=PSIP1 PE=1 SV=1" "0.000" "False" "49.257" "33" "18" "25" "17" "530" "60.1" "9.13" "68.19" "18" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00855, Pf11467" "11168" "ENSG00000164985" "PSIP1" "D3DRI9; hsa:11168; O00256; O75475; O95368; Q6P391; Q86YB9; Q9NZI3; Q9UER6" "MECP2 and associated Rett syndrome" "Vpr-mediated nuclear import of PICs; Formation of WDR5-containing histone-modifying complexes; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection" "8" "1" "1.044" "1.059" "1.021" "1.034" "1.043" "1.026" "1.031" "1.037" "1.045" "2973.0" "3103.7" "3148.1" "3034.0" "3074.6" "3102.2" "3050.4" "3064.7" "3083.3" "3107.7" "" "" "" "" "" "" "" "" "" "" "2785.7" "2568.3" "2922.6" "2345.4" "2620.7" "2963.8" "2787.3" "2721.2" "3083.3" "2992.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4288023909312929848" "False" "High" "IsMasterProtein" "P06744" "Glucose-6-phosphate isomerase OS=Homo sapiens OX=9606 GN=GPI PE=1 SV=4" "0.000" "False" "49.211" "33" "17" "28" "17" "558" "63.1" "8.32" "86.91" "17" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00342" "2821" "ENSG00000105220" "GPI" "B4DG39; hsa:2821; P06744; Q9BRD3; Q9BSK5; Q9UHE6" "Cori cycle; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; N-glycan biosynthesis; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts" "Glycolysis; Gluconeogenesis; Neutrophil degranulation; TP53 Regulates Metabolic Genes" "13" "0" "0.996" "0.963" "0.970" "0.916" "0.900" "0.902" "0.909" "0.955" "0.941" "3535.4" "3522.2" "3404.4" "3429.3" "3238.3" "3182.3" "3189.0" "3214.9" "3374.9" "3328.1" "" "" "" "" "" "" "" "" "" "" "3312.7" "2914.6" "3160.5" "2651.0" "2760.2" "3040.4" "2913.9" "2854.5" "3374.9" "3204.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3531814392904203237" "False" "High" "IsMasterProtein" "P09884" "DNA polymerase alpha catalytic subunit OS=Homo sapiens OX=9606 GN=POLA1 PE=1 SV=2" "0.000" "False" "49.186" "13" "17" "19" "17" "1462" "165.8" "5.85" "50.53" "17" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00136, Pf03104, Pf08996, Pf12254" "5422" "ENSG00000101868" "POLA1" "hsa:5422; P09884; Q86UQ7" "Retinoblastoma gene in cancer; Pyrimidine metabolism; DNA replication" "Activation of the pre-replicative complex; Defective pyroptosis; G1/S-Specific Transcription; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate" "13" "0" "0.957" "0.981" "0.983" "0.969" "0.956" "0.965" "0.949" "0.913" "0.961" "1643.4" "1573.0" "1611.9" "1616.1" "1592.7" "1571.7" "1585.9" "1559.2" "1499.7" "1580.1" "" "" "" "" "" "" "" "" "" "" "1539.9" "1301.6" "1496.4" "1249.3" "1357.6" "1501.6" "1449.1" "1384.4" "1499.7" "1521.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6037717816811945701" "False" "High" "IsMasterProtein" "Q5T8P6" "RNA-binding protein 26 OS=Homo sapiens OX=9606 GN=RBM26 PE=1 SV=3" "0.000" "False" "49.145" "15" "15" "18" "14" "1007" "113.5" "9.16" "61.24" "15" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf01480" "64062" "ENSG00000139746" "RBM26" "B4DZE0; hsa:64062; Q2NKM2; Q2NKQ2; Q5CZH8; Q5T8P5; Q5T8P6; Q5T8P8; Q5U5P5; Q5W0G7; Q8N3H5; Q96K92; Q96SZ3; Q9H2F8; Q9H7F9; Q9P1G7" "" "" "0" "1" "1.022" "1.034" "1.096" "1.077" "1.066" "1.095" "1.108" "1.093" "1.104" "2369.0" "2421.3" "2450.7" "2597.2" "2550.6" "2525.0" "2593.8" "2625.6" "2588.3" "2616.2" "" "" "" "" "" "" "" "" "" "" "2219.8" "2003.6" "2275.2" "2007.8" "2174.0" "2412.4" "2370.1" "2331.3" "2588.3" "2519.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8360736340109521171" "False" "High" "IsMasterProtein" "P57737" "Coronin-7 OS=Homo sapiens OX=9606 GN=CORO7 PE=1 SV=2" "0.000" "False" "49.126" "21" "18" "21" "18" "925" "100.5" "5.80" "60.03" "18" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "cytoskeletal activity" "Pf00400, Pf08953, Pf16300" "79585" "ENSG00000262246; ENSG00000282725" "CORO7" "B4DFD6; B4DL18; hsa:79585; I3L416; P57737; Q17RK4" "" "" "0" "0" "1.073" "1.027" "1.043" "1.028" "1.025" "0.999" "0.947" "0.990" "1.032" "1487.4" "1596.5" "1527.3" "1551.0" "1528.6" "1525.2" "1485.9" "1408.5" "1472.3" "1535.1" "" "" "" "" "" "" "" "" "" "" "1393.7" "1321.0" "1417.9" "1199.0" "1302.9" "1457.2" "1357.7" "1250.6" "1472.3" "1478.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6180366262275080504" "False" "High" "IsMasterProtein" "P00505" "Aspartate aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=GOT2 PE=1 SV=3" "0.000" "False" "49.084" "30" "13" "29" "13" "430" "47.5" "9.01" "86.18" "13" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;mitochondrion" "other molecular function" "Pf00155" "2806" "ENSG00000125166" "GOT2" "B4DJA6; E7ERW2; hsa:2806; P00505; Q53FL3; Q9BWA3" "Alanine and aspartate metabolism; Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glyoxylate metabolism and glycine degradation; Gluconeogenesis; Aspartate and asparagine metabolism; Glutamate and glutamine metabolism; Degradation of cysteine and homocysteine" "11" "0" "0.969" "0.978" "0.967" "0.926" "1.068" "0.914" "0.968" "0.912" "0.941" "4574.7" "4434.3" "4472.2" "4424.7" "4235.6" "4887.0" "4181.0" "4429.5" "4173.6" "4303.1" "" "" "" "" "" "" "" "" "" "" "4286.5" "3669.4" "4151.9" "3420.5" "3610.4" "4669.1" "3820.3" "3933.0" "4173.6" "4143.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "479793662138796228" "False" "High" "IsMasterProtein" "P61221" "ATP-binding cassette sub-family E member 1 OS=Homo sapiens OX=9606 GN=ABCE1 PE=1 SV=1" "0.000" "False" "49.077" "21" "13" "23" "13" "599" "67.3" "8.34" "69.17" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;mitochondrion;translational apparatus;other cell component" "enzyme regulator activity;translation activity;other molecular function" "Pf00005, Pf00037, Pf04068" "6059" "ENSG00000164163" "ABCE1" "hsa:6059; O88793; P61221; Q13181; Q13864; Q6NR76; Q96AL0; Q96B10; Q99K66" "" "OAS antiviral response; Interferon alpha/beta signaling" "2" "0" "0.985" "0.983" "0.915" "0.936" "0.951" "0.953" "0.976" "0.970" "0.923" "2524.2" "2486.7" "2481.7" "2310.8" "2362.2" "2399.6" "2405.4" "2463.6" "2447.6" "2330.5" "" "" "" "" "" "" "" "" "" "" "2365.2" "2057.7" "2303.9" "1786.4" "2013.5" "2292.6" "2197.9" "2187.4" "2447.6" "2244.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5264367170864335030" "False" "High" "IsMasterProtein" "Q96K76" "Ubiquitin carboxyl-terminal hydrolase 47 OS=Homo sapiens OX=9606 GN=USP47 PE=1 SV=3" "0.000" "False" "49.076" "13" "16" "21" "16" "1375" "157.2" "5.08" "60.54" "16" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf19718" "55031" "ENSG00000170242" "USP47" "B3KXF5; E9PM46; hsa:55031; Q658U0; Q86Y73; Q8TEP6; Q96K76; Q9BWI0; Q9NWN1" "" "Ub-specific processing proteases" "1" "0" "1.044" "1.042" "1.052" "1.115" "1.116" "1.061" "1.062" "1.096" "1.109" "1627.8" "1699.5" "1696.3" "1712.8" "1814.3" "1816.9" "1727.2" "1729.1" "1784.4" "1805.2" "" "" "" "" "" "" "" "" "" "" "1525.3" "1406.3" "1574.8" "1324.1" "1546.5" "1735.8" "1578.2" "1535.3" "1784.4" "1738.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6123184333862718981" "False" "High" "IsMasterProtein" "Q96BY6" "Dedicator of cytokinesis protein 10 OS=Homo sapiens OX=9606 GN=DOCK10 PE=1 SV=3" "0.000" "False" "49.072" "8" "18" "20" "18" "2186" "249.4" "7.14" "63.99" "18" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "55619" "ENSG00000135905" "DOCK10" "B3FL70; hsa:55619; O75178; Q68DA4; Q96BY6; Q9NW06; Q9NXI8" "" "Factors involved in megakaryocyte development and platelet production; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle" "5" "0" "0.961" "0.999" "0.941" "0.977" "0.986" "0.933" "0.939" "0.953" "0.958" "1714.2" "1647.2" "1712.7" "1613.5" "1674.7" "1690.6" "1598.7" "1609.3" "1633.2" "1641.8" "" "" "" "" "" "" "" "" "" "" "1606.2" "1363.0" "1590.0" "1247.3" "1427.4" "1615.2" "1460.8" "1428.9" "1633.2" "1580.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6612546022737726869" "False" "High" "IsMasterProtein" "P80303" "Nucleobindin-2 OS=Homo sapiens OX=9606 GN=NUCB2 PE=1 SV=3" "0.000" "False" "49.051" "42" "15" "22" "15" "420" "50.2" "5.12" "62.53" "15" "signal transduction" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf13499" "4925" "ENSG00000070081" "NUCB2" "A8K642; D3DQX5; hsa:4925; P80303; Q8NFT5; V9HW75" "" "" "0" "0" "1.039" "0.976" "1.028" "0.995" "1.053" "1.038" "1.093" "1.039" "1.017" "1550.0" "1611.1" "1513.5" "1593.8" "1541.8" "1632.5" "1609.1" "1693.9" "1609.8" "1576.5" "" "" "" "" "" "" "" "" "" "" "1452.4" "1333.1" "1405.1" "1232.1" "1314.2" "1559.7" "1470.3" "1504.0" "1609.8" "1518.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2273417600798469774" "False" "High" "IsMasterProtein" "Q10570" "Cleavage and polyadenylation specificity factor subunit 1 OS=Homo sapiens OX=9606 GN=CPSF1 PE=1 SV=2" "0.000" "False" "49.004" "13" "18" "22" "18" "1443" "160.8" "6.40" "71.27" "18" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "29894" "ENSG00000071894; ENSG00000285049" "CPSF1" "hsa:29894; Q10570; Q96AF0" "mRNA processing" "Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "7" "0" "0.973" "1.004" "1.159" "1.169" "1.130" "1.413" "1.405" "1.350" "1.175" "1787.0" "1738.1" "1794.6" "2070.4" "2088.1" "2020.1" "2524.9" "2511.5" "2413.0" "2098.9" "" "" "" "" "" "" "" "" "" "" "1674.4" "1438.2" "1666.0" "1600.5" "1779.9" "1930.0" "2307.1" "2230.0" "2413.0" "2021.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6590851508053806454" "False" "High" "IsMasterProtein" "Q9BQ52" "Zinc phosphodiesterase ELAC protein 2 OS=Homo sapiens OX=9606 GN=ELAC2 PE=1 SV=2" "0.000" "False" "48.836" "20" "15" "21" "15" "826" "92.2" "7.90" "63.53" "15" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf12706, Pf13691" "60528" "ENSG00000006744" "ELAC2" "B4DPL9; hsa:60528; Q6IA94; Q9BQ52; Q9HAS8; Q9HAS9; Q9NVT1" "" "tRNA processing in the nucleus; tRNA processing in the mitochondrion; rRNA processing in the mitochondrion; tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis" "4" "0" "0.964" "0.992" "1.001" "0.952" "0.972" "1.000" "0.990" "0.997" "0.978" "1889.4" "1821.3" "1874.5" "1891.2" "1798.8" "1836.3" "1889.0" "1869.6" "1883.7" "1847.8" "" "" "" "" "" "" "" "" "" "" "1770.4" "1507.1" "1740.2" "1462.0" "1533.3" "1754.4" "1726.0" "1660.0" "1883.7" "1779.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1231047339708811007" "False" "High" "IsMasterProtein" "O00203" "AP-3 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP3B1 PE=1 SV=3" "0.000" "False" "48.794" "14" "17" "24" "17" "1094" "121.2" "6.04" "70.45" "17" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf14796, Pf14797" "8546" "ENSG00000132842" "AP3B1" "E5RJ68; hsa:8546; O00203; O00580; Q7Z393; Q9HD66" "" "Golgi Associated Vesicle Biogenesis; Signaling by BRAF and RAF1 fusions" "2" "0" "0.938" "0.998" "0.976" "0.971" "0.995" "0.937" "0.921" "0.942" "0.986" "2206.5" "2069.9" "2202.0" "2153.0" "2143.4" "2195.5" "2067.8" "2031.9" "2079.5" "2175.8" "" "" "" "" "" "" "" "" "" "" "2067.5" "1712.8" "2044.3" "1664.4" "1827.0" "2097.6" "1889.4" "1804.1" "2079.5" "2094.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2454508349601298395" "False" "High" "IsMasterProtein" "Q99447" "Ethanolamine-phosphate cytidylyltransferase OS=Homo sapiens OX=9606 GN=PCYT2 PE=1 SV=1" "0.000" "False" "48.621" "35" "13" "24" "13" "389" "43.8" "6.92" "68.78" "13" "other metabolic processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01467" "5833" "ENSG00000185813" "PCYT2" "B7Z7A5; B7ZAS0; F5H8B1; hsa:5833; Q6IBM3; Q96G08; Q99447" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids" "Synthesis of PE" "5" "0" "0.971" "0.980" "0.991" "0.985" "0.974" "0.940" "0.964" "0.936" "0.956" "2271.0" "2205.1" "2225.1" "2250.6" "2236.3" "2211.2" "2133.8" "2189.1" "2124.7" "2170.2" "" "" "" "" "" "" "" "" "" "" "2127.9" "1824.7" "2065.7" "1739.8" "1906.1" "2112.6" "1949.7" "1943.7" "2124.7" "2089.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2411801021050745689" "False" "High" "IsMasterProtein" "Q9NSE4" "Isoleucine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=IARS2 PE=1 SV=2" "0.000" "False" "48.617" "15" "14" "27" "14" "1012" "113.7" "7.20" "72.00" "14" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00133, Pf06827, Pf08264" "55699" "ENSG00000067704" "IARS2" "B2RPG8; hsa:55699; Q1M2P9; Q6PI85; Q7L439; Q86WU9; Q96D91; Q9H9Q8; Q9NSE4; Q9NW42" "" "Mitochondrial protein degradation; Mitochondrial tRNA aminoacylation" "2" "0" "0.966" "1.020" "0.957" "1.004" "1.021" "0.939" "1.010" "0.961" "0.993" "2719.4" "2626.0" "2772.9" "2602.9" "2730.2" "2776.1" "2554.7" "2747.7" "2614.7" "2700.2" "" "" "" "" "" "" "" "" "" "" "2548.1" "2173.0" "2574.2" "2012.1" "2327.2" "2652.3" "2334.3" "2439.7" "2614.7" "2599.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3269209104434095274" "False" "High" "IsMasterProtein" "P40227" "T-complex protein 1 subunit zeta OS=Homo sapiens OX=9606 GN=CCT6A PE=1 SV=3" "0.000" "False" "48.577" "25" "14" "30" "14" "531" "58.0" "6.68" "85.72" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "908" "ENSG00000146731" "CCT6A" "A6NCD2; hsa:908; P40227; Q3KP28; Q75LP4; Q96S46" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC" "7" "0" "0.958" "0.961" "0.954" "0.949" "0.928" "0.935" "0.975" "0.924" "0.925" "2681.5" "2568.8" "2575.6" "2559.4" "2546.1" "2487.4" "2507.5" "2614.1" "2478.6" "2479.8" "" "" "" "" "" "" "" "" "" "" "2512.6" "2125.6" "2391.2" "1978.5" "2170.2" "2376.5" "2291.1" "2321.1" "2478.6" "2387.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "114843226561293462" "False" "High" "IsMasterProtein" "P67936" "Tropomyosin alpha-4 chain OS=Homo sapiens OX=9606 GN=TPM4 PE=1 SV=3" "0.000" "False" "48.527" "45" "15" "37" "5" "248" "28.5" "4.69" "110.08" "15" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00261" "7171" "ENSG00000167460" "TPM4" "hsa:7171; P07226; P67936; Q15659; Q5U0D9; Q9BU85; Q9H8Q3; Q9UCS1; Q9UCS2; Q9UCS3; Q9UCS4" "Striated muscle contraction pathway" "Signaling by ALK fusions and activated point mutants; RHOV GTPase cycle; Smooth Muscle Contraction; Striated Muscle Contraction" "5" "9" "1.129" "0.989" "1.013" "0.989" "0.953" "0.956" "0.999" "0.976" "0.950" "4951.8" "5590.8" "4897.5" "5015.6" "4897.3" "4719.4" "4735.4" "4947.8" "4831.3" "4704.1" "" "" "" "" "" "" "" "" "" "" "4639.8" "4626.4" "4546.7" "3877.3" "4174.3" "4509.0" "4326.9" "4393.2" "4831.3" "4529.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5224017387005900556" "False" "High" "IsMasterProtein" "Q9Y4A5" "Transformation/transcription domain-associated protein OS=Homo sapiens OX=9606 GN=TRRAP PE=1 SV=3" "0.000" "False" "48.472" "4" "17" "18" "17" "3859" "437.3" "8.19" "54.57" "17" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00454, Pf02259, Pf20175, Pf20206" "8295" "ENSG00000196367" "TRRAP" "A4D265; hsa:8295; O75218; Q9Y4A5; Q9Y631; Q9Y6H4" "Rett syndrome" "Ub-specific processing proteases; Formation of the beta-catenin:TCF transactivating complex; HATs acetylate histones" "4" "0" "1.003" "1.002" "1.025" "1.023" "0.988" "0.974" "0.968" "0.985" "1.024" "2232.5" "2238.2" "2236.2" "2288.9" "2284.2" "2206.4" "2173.4" "2161.3" "2199.9" "2287.1" "" "" "" "" "" "" "" "" "" "" "2091.8" "1852.1" "2076.0" "1769.4" "1947.0" "2108.0" "1985.9" "1919.0" "2199.9" "2202.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4773020118127395212" "False" "High" "IsMasterProtein" "P30740" "Leukocyte elastase inhibitor OS=Homo sapiens OX=9606 GN=SERPINB1 PE=1 SV=1" "0.000" "False" "48.467" "38" "13" "25" "13" "379" "42.7" "6.28" "85.93" "13" "cell cycle OR cell proliferation;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf00079" "1992" "ENSG00000021355" "SERPINB1" "A8K5L2; B4DNT0; hsa:1992; P30740; Q53FB9; Q5W0E1; Q9UDF8" "Vitamin D receptor pathway" "Neutrophil degranulation" "2" "0" "0.965" "1.013" "1.024" "1.001" "1.012" "0.979" "1.004" "1.015" "1.043" "2111.7" "2037.5" "2139.7" "2162.9" "2114.1" "2137.6" "2067.9" "2119.6" "2143.9" "2203.2" "" "" "" "" "" "" "" "" "" "" "1978.6" "1686.0" "1986.5" "1672.0" "1802.0" "2042.2" "1889.5" "1882.0" "2143.9" "2121.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1529174177095472519" "False" "High" "IsMasterProtein" "O14777" "Kinetochore protein NDC80 homolog OS=Homo sapiens OX=9606 GN=NDC80 PE=1 SV=1" "0.000" "False" "48.448" "22" "16" "17" "16" "642" "73.9" "5.60" "57.38" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03801, Pf18077" "10403" "ENSG00000080986" "NDC80" "hsa:10403; O14777; Q6PJX2" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.013" "1.011" "0.953" "0.966" "0.984" "0.871" "0.867" "0.887" "0.993" "2920.8" "2959.4" "2952.9" "2783.5" "2820.4" "2873.3" "2545.4" "2533.7" "2590.4" "2900.3" "" "" "" "" "" "" "" "" "" "" "2736.8" "2448.9" "2741.4" "2151.8" "2404.1" "2745.2" "2325.8" "2249.6" "2590.4" "2792.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6585678134614880292" "False" "High" "IsMasterProtein" "Q9NTK5" "Obg-like ATPase 1 OS=Homo sapiens OX=9606 GN=OLA1 PE=1 SV=2" "0.000" "False" "48.424" "36" "14" "21" "14" "396" "44.7" "7.81" "62.84" "14" "other metabolic processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "translation activity;other molecular function" "Pf01926, Pf06071" "29789" "ENSG00000138430" "OLA1" "D7EHM2; hsa:29789; Q5BJD7; Q8NCI8; Q96CU1; Q96SV2; Q9NTK5; Q9P1D3; Q9UNY9; Q9Y6G4" "" "Platelet degranulation" "1" "0" "0.987" "1.011" "0.984" "0.958" "0.954" "0.931" "0.950" "0.985" "0.974" "4264.6" "4209.2" "4310.9" "4196.4" "4087.4" "4067.5" "3970.8" "4052.8" "4200.5" "4151.9" "" "" "" "" "" "" "" "" "" "" "3995.9" "3483.1" "4002.1" "3244.0" "3484.0" "3886.1" "3628.2" "3598.4" "4200.5" "3997.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4186316132273188222" "False" "High" "IsMasterProtein" "Q92538" "Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=GBF1 PE=1 SV=3" "0.000" "False" "48.324" "9" "16" "19" "16" "1860" "206.4" "5.73" "50.76" "16" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf01369, Pf12783" "8729" "ENSG00000107862" "GBF1" "A0A7P0RGV0; hsa:8729; Q149P0; Q149P1; Q5VXX3; Q92538; Q96CK6; Q96HZ3; Q9H473" "" "VxPx cargo-targeting to cilium; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; trans-Golgi Network Vesicle Budding" "4" "0" "1.035" "1.017" "1.050" "1.051" "1.024" "0.986" "0.912" "0.952" "1.024" "2108.1" "2181.0" "2144.8" "2213.2" "2215.2" "2158.8" "2078.2" "1921.9" "2007.2" "2158.3" "" "" "" "" "" "" "" "" "" "" "1975.3" "1804.7" "1991.1" "1710.9" "1888.2" "2062.6" "1898.9" "1706.4" "2007.2" "2078.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5201863361074030149" "False" "High" "IsMasterProtein" "O95071" "E3 ubiquitin-protein ligase UBR5 OS=Homo sapiens OX=9606 GN=UBR5 PE=1 SV=2" "0.000" "False" "48.245" "7" "18" "20" "18" "2799" "309.2" "5.85" "47.72" "18" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00632, Pf00658, Pf11547" "51366" "ENSG00000104517" "UBR5" "B2RP24; hsa:51366; J3KMW7; O94970; O95071; Q9NPL3" "Mesodermal commitment pathway" "" "1" "0" "1.037" "0.976" "0.974" "0.975" "0.961" "0.904" "0.830" "0.878" "0.965" "1654.1" "1715.7" "1613.7" "1611.3" "1613.3" "1589.4" "1494.6" "1372.2" "1453.1" "1595.7" "" "" "" "" "" "" "" "" "" "" "1549.9" "1419.7" "1498.1" "1245.6" "1375.1" "1518.5" "1365.7" "1218.4" "1453.1" "1536.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7470161461111362497" "False" "High" "IsMasterProtein" "Q7Z4S6" "Kinesin-like protein KIF21A OS=Homo sapiens OX=9606 GN=KIF21A PE=1 SV=2" "0.000" "False" "48.220" "10" "16" "20" "13" "1674" "187.1" "6.42" "59.74" "16" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf00400" "55605" "ENSG00000139116" "KIF21A" "A8MX28; B0I1R9; B9EGE4; F5H0C3; F5H219; hsa:55605; Q2UVF1; Q6UKL9; Q7Z4S6; Q7Z668; Q86WZ5; Q8IVZ8; Q9C0F5; Q9NXU4; Q9Y590" "" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "2" "0" "1.047" "1.011" "1.061" "1.066" "1.018" "0.974" "0.950" "0.995" "1.005" "1342.3" "1405.3" "1357.1" "1424.5" "1430.8" "1367.1" "1306.8" "1275.7" "1335.6" "1349.5" "" "" "" "" "" "" "" "" "" "" "1257.7" "1162.9" "1259.9" "1101.2" "1219.5" "1306.1" "1194.0" "1132.7" "1335.6" "1299.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8008274239603490952" "False" "High" "IsMasterProtein" "P51991" "Heterogeneous nuclear ribonucleoprotein A3 OS=Homo sapiens OX=9606 GN=HNRNPA3 PE=1 SV=2" "0.000" "False" "48.178" "38" "16" "42" "14" "378" "39.6" "9.01" "120.76" "16" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "220988" "ENSG00000170144" "HNRNPA3" "D3DPF4; hsa:220988; P51991; Q53RW7; Q6URK5" "" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "2" "0" "1.289" "1.011" "1.185" "1.067" "0.950" "1.089" "0.989" "1.135" "1.081" "1405.0" "1811.3" "1420.1" "1665.1" "1498.7" "1334.3" "1529.5" "1389.8" "1594.8" "1518.7" "" "" "" "" "" "" "" "" "" "" "1316.5" "1498.8" "1318.3" "1287.2" "1277.4" "1274.8" "1397.6" "1234.0" "1594.8" "1462.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1721823371863977969" "False" "High" "IsMasterProtein" "Q92973" "Transportin-1 OS=Homo sapiens OX=9606 GN=TNPO1 PE=1 SV=2" "0.000" "False" "48.159" "19" "15" "20" "10" "898" "102.3" "4.98" "57.09" "15" "transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf02985, Pf03810, Pf13513" "3842" "ENSG00000083312" "TNPO1" "B4DVC6; hsa:3842; Q92957; Q92973; Q92975" "22q11.2 copy number variation syndrome" "Postmitotic nuclear pore complex (NPC) reformation; Intraflagellar transport; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA" "4" "4" "0.980" "1.017" "0.997" "0.998" "1.013" "0.987" "1.003" "0.975" "1.003" "2270.5" "2224.1" "2308.5" "2262.8" "2265.9" "2300.3" "2241.5" "2276.2" "2214.6" "2278.4" "" "" "" "" "" "" "" "" "" "" "2127.4" "1840.4" "2143.2" "1749.3" "1931.4" "2197.7" "2048.1" "2021.0" "2214.6" "2193.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-108024960006830899" "False" "High" "IsMasterProtein" "Q99873" "Protein arginine N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=PRMT1 PE=1 SV=3" "0.000" "False" "48.116" "35" "12" "37" "12" "371" "42.4" "5.35" "72.56" "12" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13649" "3276" "ENSG00000126457" "PRMT1" "A0A087X1W2; B4E3C3; G5E9B6; H7C2I1; hsa:3276; Q15529; Q2VP93; Q6LEU5; Q8WUW5; Q99872; Q99873; Q99874; Q9NZ04; Q9NZ05; Q9NZ06" "Energy metabolism; mRNA processing; Nitric oxide metabolism in cystic fibrosis; 16p11.2 distal deletion syndrome; Interferon type I signaling pathways" "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Extra-nuclear estrogen signaling; Estrogen-dependent gene expression; RMTs methylate histone arginines; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Maturation of nucleoprotein" "11" "0" "0.977" "1.055" "1.004" "1.007" "0.982" "0.982" "1.020" "1.038" "1.001" "1672.0" "1632.9" "1763.8" "1679.0" "1683.9" "1641.7" "1642.3" "1705.5" "1735.5" "1673.8" "" "" "" "" "" "" "" "" "" "" "1566.6" "1351.2" "1637.5" "1297.9" "1435.3" "1568.5" "1500.6" "1514.3" "1735.5" "1611.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3390977729729594241" "False" "High" "IsMasterProtein" "P14735" "Insulin-degrading enzyme OS=Homo sapiens OX=9606 GN=IDE PE=1 SV=4" "0.000" "False" "48.107" "16" "17" "19" "17" "1019" "117.9" "6.61" "62.66" "17" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00675, Pf05193, Pf16187" "3416" "ENSG00000119912" "IDE" "B2R721; B7ZAU2; D3DR35; hsa:3416; P14735; Q5T5N2" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "Ub-specific processing proteases; Peroxisomal protein import; Insulin receptor recycling" "5" "0" "0.923" "0.997" "0.963" "1.015" "1.016" "0.951" "1.034" "0.988" "1.025" "2678.3" "2471.2" "2670.9" "2578.9" "2717.6" "2721.7" "2546.1" "2769.8" "2645.2" "2744.4" "" "" "" "" "" "" "" "" "" "" "2509.5" "2044.9" "2479.6" "1993.6" "2316.4" "2600.3" "2326.5" "2459.3" "2645.2" "2642.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1403066018753267541" "False" "High" "IsMasterProtein" "Q96RU3" "Formin-binding protein 1 OS=Homo sapiens OX=9606 GN=FNBP1 PE=1 SV=2" "0.000" "False" "48.034" "24" "15" "24" "15" "617" "71.3" "5.72" "66.25" "15" "transport;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00611" "23048" "ENSG00000187239" "FNBP1" "B7ZL12; E9PGQ4; hsa:23048; O60301; Q3MIN8; Q5TC87; Q5TC88; Q6P658; Q7LGG2; Q96RU3; Q9H8H8; Q9NWD1" "" "Clathrin-mediated endocytosis; CDC42 GTPase cycle; RND2 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle" "5" "0" "1.070" "1.023" "0.977" "1.065" "1.051" "1.038" "1.029" "0.999" "1.036" "2289.6" "2449.7" "2343.3" "2237.7" "2438.2" "2407.4" "2376.5" "2357.0" "2286.8" "2372.2" "" "" "" "" "" "" "" "" "" "" "2145.3" "2027.1" "2175.4" "1729.8" "2078.3" "2300.0" "2171.5" "2092.7" "2286.8" "2284.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "325736081283403068" "False" "High" "IsMasterProtein" "P35637" "RNA-binding protein FUS OS=Homo sapiens OX=9606 GN=FUS PE=1 SV=1" "0.000" "False" "48.005" "20" "8" "27" "6" "526" "53.4" "9.36" "76.01" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641" "2521" "ENSG00000089280" "FUS" "hsa:2521; P35637; Q9H4A8" "MECP2 and associated Rett syndrome; mRNA processing; HDAC6 interactions in the central nervous system" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "5" "2" "1.083" "1.069" "1.058" "1.080" "1.133" "1.042" "1.149" "1.062" "1.085" "1901.7" "2058.8" "2032.9" "2011.4" "2054.0" "2155.0" "1981.8" "2185.2" "2020.1" "2063.3" "" "" "" "" "" "" "" "" "" "" "1781.9" "1703.6" "1887.3" "1554.9" "1750.8" "2058.9" "1810.8" "1940.3" "2020.1" "1986.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1146438711958021826" "False" "High" "IsMasterProtein" "Q16851" "UTP--glucose-1-phosphate uridylyltransferase OS=Homo sapiens OX=9606 GN=UGP2 PE=1 SV=5" "0.000" "False" "47.924" "28" "15" "26" "15" "508" "56.9" "8.15" "77.02" "15" "other metabolic processes;developmental processes" "cytosol;other cell component" "other molecular function" "Pf01704" "7360" "ENSG00000169764" "UGP2" "hsa:7360; Q07131; Q0P6K2; Q16851; Q86Y81; Q9BU15" "Exercise-induced circadian regulation; Glycogen synthesis and degradation; Glucuronidation" "Glycogen synthesis; Formation of the active cofactor, UDP-glucuronate" "5" "0" "0.955" "0.939" "0.944" "0.930" "0.916" "0.924" "0.939" "0.920" "0.939" "2906.2" "2775.1" "2729.0" "2743.4" "2703.5" "2662.7" "2684.8" "2728.8" "2673.5" "2730.1" "" "" "" "" "" "" "" "" "" "" "2723.1" "2296.3" "2533.6" "2120.8" "2304.4" "2544.0" "2453.2" "2422.9" "2673.5" "2628.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8579706144891720478" "False" "High" "IsMasterProtein" "O00267" "Transcription elongation factor SPT5 OS=Homo sapiens OX=9606 GN=SUPT5H PE=1 SV=1" "0.000" "False" "47.743" "15" "15" "18" "15" "1087" "120.9" "5.06" "56.11" "15" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00467, Pf03439, Pf11942" "6829" "ENSG00000196235" "SUPT5H" "hsa:6829; O00267; O43279; Q59G52; Q99639" "Initiation of transcription and translation elongation at the HIV-1 LTR; mRNA processing" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "20" "0" "0.987" "1.027" "0.962" "0.943" "0.915" "0.962" "0.882" "0.989" "0.965" "1945.8" "1919.6" "1998.6" "1871.6" "1834.6" "1780.6" "1871.8" "1715.5" "1923.6" "1877.2" "" "" "" "" "" "" "" "" "" "" "1823.2" "1588.5" "1855.4" "1446.8" "1563.8" "1701.2" "1710.3" "1523.2" "1923.6" "1807.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3668723528538727638" "False" "High" "IsMasterProtein" "Q9UDT6" "CAP-Gly domain-containing linker protein 2 OS=Homo sapiens OX=9606 GN=CLIP2 PE=1 SV=1" "0.000" "False" "47.700" "14" "16" "19" "13" "1046" "115.8" "6.73" "56.23" "16" "cell organization and biogenesis" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf01302" "7461" "ENSG00000106665" "CLIP2" "hsa:7461; O14527; O43611; Q9UDT6" "7q11.23 copy number variation syndrome" "" "1" "2" "1.028" "0.960" "1.085" "0.983" "0.972" "0.954" "0.931" "0.948" "0.952" "2598.1" "2671.2" "2493.1" "2818.2" "2554.8" "2525.9" "2477.9" "2419.6" "2461.8" "2472.6" "" "" "" "" "" "" "" "" "" "" "2434.4" "2210.3" "2314.6" "2178.6" "2177.7" "2413.3" "2264.1" "2148.4" "2461.8" "2380.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6241342632728061571" "False" "High" "IsMasterProtein" "O43148" "mRNA cap guanine-N7 methyltransferase OS=Homo sapiens OX=9606 GN=RNMT PE=1 SV=1" "0.000" "False" "47.699" "37" "15" "19" "15" "476" "54.8" "6.61" "59.08" "15" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03291" "8731" "ENSG00000101654" "RNMT" "B0YJ90; D3DUJ5; hsa:8731; O43148; O94996; Q9UIJ9" "mRNA processing; 15q25 copy number variation" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "5" "0" "0.992" "1.051" "1.004" "0.988" "0.985" "0.936" "1.024" "1.011" "0.984" "2393.1" "2373.6" "2514.3" "2403.7" "2365.2" "2357.0" "2238.9" "2449.5" "2419.0" "2355.5" "" "" "" "" "" "" "" "" "" "" "2242.3" "1964.1" "2334.2" "1858.2" "2016.1" "2251.9" "2045.8" "2174.9" "2419.0" "2268.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2260332764015544813" "False" "High" "IsMasterProtein" "Q9BTW9" "Tubulin-specific chaperone D OS=Homo sapiens OX=9606 GN=TBCD PE=1 SV=2" "0.000" "False" "47.616" "14" "14" "22" "14" "1192" "132.5" "6.19" "68.91" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf12612" "6904" "ENSG00000141556" "TBCD" "hsa:6904; O95458; Q7L8K1; Q8IXP6; Q8NAX0; Q8WYH4; Q96E74; Q9BTW9; Q9UF82; Q9UG46; Q9Y2J3" "" "Post-chaperonin tubulin folding pathway" "1" "0" "0.927" "0.978" "0.991" "0.991" "0.964" "0.923" "0.952" "0.935" "0.976" "1692.4" "1569.6" "1654.3" "1677.5" "1677.2" "1630.8" "1562.5" "1611.5" "1582.5" "1652.2" "" "" "" "" "" "" "" "" "" "" "1585.7" "1298.8" "1535.8" "1296.8" "1429.6" "1558.1" "1427.7" "1430.9" "1582.5" "1590.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7326537803977903766" "False" "High" "IsMasterProtein" "P02786" "Transferrin receptor protein 1 OS=Homo sapiens OX=9606 GN=TFRC PE=1 SV=2" "0.000" "False" "47.586" "19" "14" "16" "14" "760" "84.8" "6.61" "57.18" "14" "stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf02225, Pf04253, Pf04389" "7037" "ENSG00000072274" "TFRC" "D3DXB0; hsa:7037; P02786; Q1HE24; Q59G55; Q9UCN0; Q9UCU5; Q9UDF9; Q9UK21" "Iron metabolism in placenta; Ferroptosis; 3q29 copy number variation syndrome; Iron metabolism disorders" "RHOC GTPase cycle; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; Golgi Associated Vesicle Biogenesis; RND1 GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; Transferrin endocytosis and recycling; RHOH GTPase cycle" "21" "0" "0.952" "1.009" "0.931" "0.935" "0.960" "0.842" "0.857" "0.889" "0.928" "2602.2" "2476.4" "2625.6" "2422.2" "2433.4" "2498.5" "2192.2" "2230.9" "2313.7" "2413.8" "" "" "" "" "" "" "" "" "" "" "2438.3" "2049.2" "2437.5" "1872.5" "2074.1" "2387.0" "2003.1" "1980.8" "2313.7" "2324.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7543503445909431130" "False" "High" "IsMasterProtein" "P13798" "Acylamino-acid-releasing enzyme OS=Homo sapiens OX=9606 GN=APEH PE=1 SV=4" "0.000" "False" "47.554" "21" "13" "22" "13" "732" "81.2" "5.48" "76.95" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00326, Pf19283" "327" "ENSG00000164062" "APEH" "hsa:327; P13798; Q9BQ33; Q9P0Y2" "" "Neutrophil degranulation; Eukaryotic Translation Termination" "2" "0" "0.998" "0.979" "1.003" "0.975" "0.990" "0.967" "0.946" "0.960" "0.975" "2772.8" "2767.2" "2713.4" "2781.6" "2703.4" "2744.2" "2680.4" "2622.6" "2662.4" "2703.5" "" "" "" "" "" "" "" "" "" "" "2598.1" "2289.8" "2519.1" "2150.3" "2304.3" "2621.8" "2449.2" "2328.6" "2662.4" "2603.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "61926280635528933" "False" "High" "IsMasterProtein" "O60885" "Bromodomain-containing protein 4 OS=Homo sapiens OX=9606 GN=BRD4 PE=1 SV=2" "0.000" "False" "47.504" "13" "16" "19" "12" "1362" "152.1" "9.19" "65.13" "16" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00439, Pf17035, Pf17105" "23476" "ENSG00000141867" "BRD4" "hsa:23476; O60433; O60885; Q4G0X8; Q86YS8; Q96PD3" "VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome" "Potential therapeutics for SARS" "3" "2" "0.999" "1.009" "0.969" "1.048" "0.981" "1.021" "1.058" "1.038" "1.045" "1926.9" "1924.9" "1944.2" "1867.5" "2019.6" "1891.2" "1967.1" "2038.2" "2000.8" "2013.4" "" "" "" "" "" "" "" "" "" "" "1805.5" "1592.8" "1804.9" "1443.7" "1721.5" "1806.9" "1797.4" "1809.7" "2000.8" "1938.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7522921008615735421" "False" "High" "IsMasterProtein" "O75152" "Zinc finger CCCH domain-containing protein 11A OS=Homo sapiens OX=9606 GN=ZC3H11A PE=1 SV=3" "0.000" "False" "47.472" "20" "16" "22" "16" "810" "89.1" "8.37" "63.05" "16" "other metabolic processes;transport" "nucleus" "other molecular function" "Pf15663" "9877" "ENSG00000058673" "ZC3H11A" "hsa:9877; O75152; Q6AHY4; Q6AHY9; Q6AW79; Q6AWA1; Q6PJK4; Q86XZ7" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "1.054" "1.033" "1.116" "1.161" "1.142" "1.217" "1.231" "1.165" "1.156" "1325.0" "1396.7" "1369.1" "1479.0" "1538.7" "1512.8" "1613.2" "1630.9" "1544.0" "1531.3" "" "" "" "" "" "" "" "" "" "" "1241.6" "1155.8" "1271.0" "1143.3" "1311.5" "1445.3" "1474.0" "1448.1" "1544.0" "1474.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8135854214922228039" "False" "High" "IsMasterProtein" "Q9BY44" "Eukaryotic translation initiation factor 2A OS=Homo sapiens OX=9606 GN=EIF2A PE=1 SV=3" "0.000" "False" "47.304" "28" "14" "20" "14" "585" "64.9" "8.87" "73.43" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity" "Pf08662" "83939" "ENSG00000144895" "EIF2A" "A8MPS6; B4DF96; B4DQ14; D3DNI9; hsa:83939; Q5QTR2; Q7Z4E9; Q8NFM1; Q96EW9; Q96K81; Q9BY44" "Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome" "" "3" "0" "1.006" "1.034" "0.986" "1.019" "1.028" "0.955" "1.010" "1.018" "0.976" "3045.1" "3062.8" "3149.3" "3002.6" "3102.0" "3130.8" "2908.6" "3075.9" "3099.9" "2970.8" "" "" "" "" "" "" "" "" "" "" "2853.2" "2534.4" "2923.7" "2321.1" "2644.1" "2991.2" "2657.7" "2731.1" "3099.9" "2860.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6099589946817253427" "False" "High" "IsMasterProtein" "Q7Z417" "FMR1-interacting protein NUFIP2 OS=Homo sapiens OX=9606 GN=NUFIP2 PE=1 SV=1" "0.000" "False" "47.217" "24" "12" "17" "12" "695" "76.1" "8.70" "61.15" "12" "" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf15293" "57532" "ENSG00000108256" "NUFIP2" "A1L3A6; A1L3A7; hsa:57532; Q7Z417; Q9P2M5" "" "" "0" "0" "1.014" "0.993" "1.112" "1.104" "1.121" "1.161" "1.155" "1.164" "1.094" "1588.7" "1610.4" "1577.2" "1766.3" "1754.5" "1781.3" "1844.9" "1835.4" "1848.8" "1737.6" "" "" "" "" "" "" "" "" "" "" "1488.6" "1332.6" "1464.2" "1365.5" "1495.5" "1701.9" "1685.7" "1629.7" "1848.8" "1673.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3873794915793825420" "False" "High" "IsMasterProtein" "Q9BYT8" "Neurolysin, mitochondrial OS=Homo sapiens OX=9606 GN=NLN PE=1 SV=1" "0.000" "False" "47.216" "23" "16" "18" "16" "704" "80.6" "6.64" "57.03" "16" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf01432" "57486" "ENSG00000123213" "NLN" "hsa:57486; Q9BYT8; Q9ULJ4" "" "Peptide ligand-binding receptors" "1" "0" "0.971" "0.978" "0.969" "0.942" "0.959" "0.932" "0.934" "0.942" "0.938" "1853.6" "1800.1" "1813.1" "1795.5" "1746.2" "1777.9" "1727.9" "1731.5" "1747.0" "1739.3" "" "" "" "" "" "" "" "" "" "" "1736.8" "1489.5" "1683.2" "1388.0" "1488.4" "1698.7" "1578.8" "1537.4" "1747.0" "1674.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2120449807322374936" "False" "High" "IsMasterProtein" "Q9Y2Z0" "Protein SGT1 homolog OS=Homo sapiens OX=9606 GN=SUGT1 PE=1 SV=3" "0.000" "False" "47.088" "38" "12" "21" "12" "365" "41.0" "5.16" "69.73" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04969, Pf05002" "10910" "ENSG00000165416" "SUGT1" "A2A303; hsa:10910; Q5JAK5; Q5TAM6; Q6VXY6; Q9Y2Z0" "Nucleotide-binding oligomerization domain (NOD) pathway" "The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection" "3" "0" "1.025" "1.000" "0.953" "1.017" "1.020" "0.963" "1.005" "1.000" "1.005" "2018.1" "2068.5" "2017.5" "1922.4" "2053.2" "2057.9" "1943.4" "2028.9" "2018.8" "2027.5" "" "" "" "" "" "" "" "" "" "" "1890.9" "1711.7" "1873.0" "1486.1" "1750.1" "1966.1" "1775.7" "1801.5" "2018.8" "1952.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5990763445808986334" "False" "High" "IsMasterProtein" "O75083" "WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=WDR1 PE=1 SV=4" "0.000" "False" "47.033" "28" "13" "19" "13" "606" "66.2" "6.65" "76.32" "13" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00400" "9948" "ENSG00000071127" "WDR1" "A8K6E9; A8MPU4; hsa:9948; O75083; O75313; Q8N6E5; Q9UG05; Q9UG78; Q9UQE0" "Hypertrophy model" "Platelet degranulation" "2" "0" "0.955" "1.049" "0.971" "0.997" "1.009" "0.937" "1.029" "1.006" "1.004" "2225.6" "2124.7" "2333.8" "2161.3" "2218.7" "2246.5" "2086.1" "2290.6" "2238.3" "2234.8" "" "" "" "" "" "" "" "" "" "" "2085.4" "1758.2" "2166.6" "1670.8" "1891.2" "2146.3" "1906.1" "2033.9" "2238.3" "2151.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1365252663665012706" "False" "High" "IsMasterProtein" "P49589" "Cysteine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=CARS1 PE=1 SV=3" "0.000" "False" "47.015" "21" "14" "24" "14" "748" "85.4" "6.76" "76.01" "14" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01406" "833" "ENSG00000110619; ENSG00000278191" "CARS1" "hsa:833; P49589; Q53XI8; Q5HYE4; Q9HD24; Q9HD25" "" "Signaling by ALK fusions and activated point mutants; Cytosolic tRNA aminoacylation" "2" "0" "1.021" "1.004" "0.998" "0.972" "0.969" "0.944" "0.917" "0.934" "0.947" "1702.6" "1738.4" "1709.9" "1698.5" "1655.7" "1650.0" "1607.9" "1561.7" "1590.5" "1612.5" "" "" "" "" "" "" "" "" "" "" "1595.4" "1438.5" "1587.4" "1313.0" "1411.3" "1576.5" "1469.2" "1386.6" "1590.5" "1552.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5833035186099414895" "False" "High" "IsMasterProtein" "Q96KR1" "Zinc finger RNA-binding protein OS=Homo sapiens OX=9606 GN=ZFR PE=1 SV=2" "0.000" "False" "46.885" "17" "18" "22" "18" "1074" "116.9" "9.04" "58.64" "18" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07528, Pf12874, Pf20965" "51663" "ENSG00000056097" "ZFR" "B2RNR5; hsa:51663; Q05C08; Q3B7X5; Q6P5A3; Q86UA0; Q96KR1; Q9H6V4; Q9NTI1; Q9Y687" "Exercise-induced circadian regulation" "" "1" "0" "0.983" "0.969" "0.926" "0.955" "0.966" "0.945" "0.931" "0.929" "0.959" "1730.0" "1700.2" "1676.4" "1601.2" "1652.0" "1671.6" "1635.1" "1611.0" "1606.9" "1659.8" "" "" "" "" "" "" "" "" "" "" "1621.0" "1406.9" "1556.4" "1237.8" "1408.1" "1597.0" "1494.1" "1430.4" "1606.9" "1598.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5761790178817742854" "False" "High" "IsMasterProtein" "Q96P70" "Importin-9 OS=Homo sapiens OX=9606 GN=IPO9 PE=1 SV=3" "0.000" "False" "46.802" "13" "14" "26" "14" "1041" "115.9" "4.81" "83.93" "14" "transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03810" "55705" "ENSG00000198700" "IPO9" "B1ASV5; hsa:55705; Q8N1Y1; Q8N3I2; Q8NCG9; Q96P70; Q96SU6; Q9NW01; Q9P0A8; Q9ULM8" "" "" "0" "0" "0.933" "0.967" "0.928" "0.932" "0.938" "0.907" "0.931" "0.930" "0.920" "3136.5" "2927.7" "3032.4" "2911.9" "2921.9" "2943.6" "2846.1" "2920.1" "2918.4" "2885.4" "" "" "" "" "" "" "" "" "" "" "2938.9" "2422.6" "2815.2" "2251.0" "2490.6" "2812.3" "2600.6" "2592.8" "2918.4" "2778.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5122002380756434681" "False" "High" "IsMasterProtein" "Q9Y6E2" "eIF5-mimic protein 1 OS=Homo sapiens OX=9606 GN=BZW2 PE=1 SV=1" "0.000" "False" "46.780" "33" "15" "32" "14" "419" "48.1" "6.68" "115.83" "15" "other biological processes" "other cell component" "" "Pf02020" "28969" "ENSG00000136261" "BZW2" "A4D123; hsa:28969; Q3B779; Q96JW5; Q9H3F7; Q9Y6E2" "" "" "0" "1" "0.954" "0.986" "0.946" "0.973" "0.950" "0.948" "0.941" "0.940" "0.945" "6238.1" "5951.3" "6153.1" "5900.6" "6071.9" "5924.8" "5915.9" "5870.2" "5862.4" "5896.2" "" "" "" "" "" "" "" "" "" "" "5845.1" "4924.6" "5712.4" "4561.4" "5175.5" "5660.6" "5405.5" "5212.1" "5862.4" "5677.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7811403610276720073" "False" "High" "IsMasterProtein" "Q99543" "DnaJ homolog subfamily C member 2 OS=Homo sapiens OX=9606 GN=DNAJC2 PE=1 SV=4" "0.000" "False" "46.778" "24" "14" "17" "14" "621" "72.0" "8.70" "57.60" "14" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "translation activity;other molecular function" "Pf00226, Pf00249, Pf16717" "27000" "ENSG00000105821" "DNAJC2" "A4VCI0; hsa:27000; Q99543; Q9BVX1" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "1.023" "0.969" "0.991" "1.006" "0.979" "0.950" "0.983" "0.952" "0.987" "3632.1" "3716.0" "3520.9" "3597.8" "3654.8" "3554.9" "3449.2" "3570.9" "3457.2" "3585.0" "" "" "" "" "" "" "" "" "" "" "3403.3" "3075.0" "3268.7" "2781.2" "3115.3" "3396.3" "3151.6" "3170.6" "3457.2" "3451.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3813799245873050122" "False" "High" "IsMasterProtein" "Q96L91" "E1A-binding protein p400 OS=Homo sapiens OX=9606 GN=EP400 PE=1 SV=4" "0.000" "False" "46.775" "6" "17" "17" "17" "3159" "343.3" "9.19" "43.80" "17" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf07529, Pf15790" "57634" "ENSG00000183495" "EP400" "hsa:57634; O15411; Q6P2F5; Q8N8Q7; Q8NE05; Q96JK7; Q96L91; Q9P230" "HDAC6 interactions in the central nervous system" "Formation of Senescence-Associated Heterochromatin Foci (SAHF); HATs acetylate histones" "4" "0" "0.989" "0.951" "1.007" "1.028" "0.979" "0.977" "0.930" "0.945" "1.009" "2251.9" "2226.0" "2142.4" "2268.5" "2314.2" "2204.9" "2200.0" "2094.9" "2127.7" "2273.2" "" "" "" "" "" "" "" "" "" "" "2110.0" "1842.0" "1988.9" "1753.7" "1972.6" "2106.6" "2010.2" "1860.1" "2127.7" "2188.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2636434062481616227" "False" "High" "IsMasterProtein" "P42858" "Huntingtin OS=Homo sapiens OX=9606 GN=HTT PE=1 SV=2" "0.000" "False" "46.666" "6" "17" "18" "17" "3142" "347.4" "6.20" "50.36" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf20925, Pf20926, Pf20927" "3064" "ENSG00000197386" "HTT" "hsa:3064; P42858; Q9UQB7" "Mesodermal commitment pathway; Mesodermal commitment pathway; ERK pathway in Huntington's disease; Rett syndrome; 15q25 copy number variation; HDAC6 interactions in the central nervous system" "Regulation of MECP2 expression and activity" "7" "0" "0.996" "0.995" "1.032" "0.992" "0.983" "0.977" "0.952" "0.967" "1.014" "1892.4" "1884.4" "1882.5" "1952.5" "1877.7" "1859.6" "1849.0" "1801.1" "1829.1" "1919.1" "" "" "" "" "" "" "" "" "" "" "1773.2" "1559.3" "1747.7" "1509.4" "1600.5" "1776.6" "1689.4" "1599.2" "1829.1" "1847.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3000409602916512702" "False" "High" "IsMasterProtein" "O15357" "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 OS=Homo sapiens OX=9606 GN=INPPL1 PE=1 SV=2" "0.000" "False" "46.657" "12" "15" "19" "13" "1258" "138.5" "6.54" "55.27" "15" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00017, Pf00536" "3636" "ENSG00000165458" "INPPL1" "B2RTX5; hsa:3636; O15357; Q13577; Q13578" "EGF/EGFR signaling pathway; Insulin signaling" "Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Synthesis of IP3 and IP4 in the cytosol; Signaling by CSF1 (M-CSF) in myeloid cells" "6" "0" "1.027" "0.992" "1.061" "1.031" "1.029" "0.998" "1.004" "0.989" "0.988" "1127.7" "1158.0" "1118.7" "1196.7" "1162.7" "1160.0" "1125.6" "1132.4" "1114.8" "1114.2" "" "" "" "" "" "" "" "" "" "" "1056.6" "958.2" "1038.5" "925.1" "991.1" "1108.3" "1028.5" "1005.4" "1114.8" "1072.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6184092773991491015" "False" "High" "IsMasterProtein" "P39748" "Flap endonuclease 1 OS=Homo sapiens OX=9606 GN=FEN1 PE=1 SV=1" "0.000" "False" "46.648" "39" "12" "22" "12" "380" "42.6" "8.62" "80.23" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00752, Pf00867" "2237" "ENSG00000168496" "FEN1" "hsa:2237; P39748" "Base excision repair; DNA repair pathways, full network" "HDR through MMEJ (alt-NHEJ); Early Phase of HIV Life Cycle; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Removal of the Flap Intermediate; Removal of the Flap Intermediate from the C-strand" "8" "0" "1.005" "1.036" "1.029" "1.013" "1.023" "1.033" "1.015" "0.978" "1.016" "1611.1" "1619.1" "1668.5" "1657.4" "1631.7" "1648.4" "1664.8" "1635.3" "1576.1" "1637.6" "" "" "" "" "" "" "" "" "" "" "1509.6" "1339.8" "1548.9" "1281.3" "1390.8" "1574.9" "1521.2" "1452.0" "1576.1" "1576.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4323933511445947970" "False" "High" "IsMasterProtein" "P43405" "Tyrosine-protein kinase SYK OS=Homo sapiens OX=9606 GN=SYK PE=1 SV=1" "0.000" "False" "46.625" "24" "13" "21" "12" "635" "72.0" "8.25" "64.52" "13" "cell adhesion;cell-cell signaling;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00017, Pf07714" "6850" "ENSG00000165025" "SYK" "hsa:6850; P43405" "IL-5 signaling pathway; RANKL/RANK signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Microglia pathogen phagocytosis pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; IL-2 signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; CLEC7A (Dectin-1) signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; DAP12 signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Integrin signaling; Interleukin-2 signaling; Dectin-2 family; FLT3 signaling through SRC family kinases" "30" "0" "0.929" "1.023" "1.003" "1.050" "0.962" "0.996" "0.948" "0.938" "1.018" "1272.1" "1181.2" "1301.3" "1275.8" "1335.9" "1223.3" "1266.5" "1206.0" "1193.4" "1295.5" "" "" "" "" "" "" "" "" "" "" "1192.0" "977.4" "1208.1" "986.3" "1138.7" "1168.7" "1157.3" "1070.8" "1193.4" "1247.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "397277040626667291" "False" "High" "IsMasterProtein" "Q9UBB4" "Ataxin-10 OS=Homo sapiens OX=9606 GN=ATXN10 PE=1 SV=1" "0.000" "False" "46.621" "35" "15" "19" "15" "475" "53.5" "5.25" "58.02" "15" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf09759" "25814" "ENSG00000130638" "ATXN10" "A6NLC4; B4DG05; hsa:25814; O14998; O15009; Q6I9X4; Q9UBB4" "Ciliopathies" "" "1" "0" "1.046" "1.055" "1.066" "1.091" "1.085" "1.051" "1.028" "1.055" "1.053" "1472.1" "1539.5" "1553.7" "1569.9" "1605.7" "1597.8" "1547.1" "1513.1" "1552.6" "1549.7" "" "" "" "" "" "" "" "" "" "" "1379.3" "1273.9" "1442.4" "1213.6" "1368.7" "1526.5" "1413.6" "1343.5" "1552.6" "1492.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "506200805167063951" "False" "High" "IsMasterProtein" "P42229" "Signal transducer and activator of transcription 5A OS=Homo sapiens OX=9606 GN=STAT5A PE=1 SV=1" "0.000" "False" "46.614" "16" "14" "21" "4" "794" "90.6" "6.39" "63.24" "14" "other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf21354" "6776" "ENSG00000126561" "STAT5A" "hsa:6776; P42229; Q1KLZ6" "IL-5 signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Puberty (Stage 2 of 4); Hematopoietic stem cell differentiation; IL-3 signaling pathway; Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; TYROBP causal network in microglia; IL-4 signaling pathway; PDGFR-beta pathway; White fat cell differentiation; Non-small cell lung cancer; EGF/EGFR signaling pathway; Measles virus infection; Hepatitis B infection; IL-2 signaling pathway; 3q29 copy number variation syndrome; FOXP3 in COVID-19; Th17 cell differentiation pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; Acute myeloid leukemia; JAK-STAT signaling in the regulation of beta cells; EPO receptor signaling; Interferon type I signaling pathways; ErbB signaling pathway" "Signaling by cytosolic FGFR1 fusion mutants; Nuclear events stimulated by ALK signaling in cancer; Interleukin-3, Interleukin-5 and GM-CSF signaling; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Growth hormone receptor signaling; Nuclear signaling by ERBB4; Signaling by Leptin; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Prolactin receptor signaling; Interleukin-20 family signaling; Erythropoietin activates STAT5; Signaling by FLT3 fusion proteins; Interleukin-2 signaling; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling; STAT5 Activation" "54" "7" "0.951" "0.980" "0.929" "0.956" "0.993" "0.931" "0.953" "0.929" "0.984" "2720.0" "2586.6" "2665.1" "2527.0" "2601.1" "2699.7" "2533.2" "2591.1" "2527.0" "2676.9" "" "" "" "" "" "" "" "" "" "" "2548.7" "2140.4" "2474.2" "1953.5" "2217.1" "2579.3" "2314.7" "2300.6" "2527.0" "2577.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "549572925276105069" "False" "High" "IsMasterProtein" "P11274" "Breakpoint cluster region protein OS=Homo sapiens OX=9606 GN=BCR PE=1 SV=2" "0.000" "False" "46.606" "13" "15" "18" "13" "1271" "142.7" "7.03" "50.27" "15" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00168, Pf00620, Pf00621, Pf09036, Pf19057" "613" "ENSG00000186716" "BCR" "hsa:613; P11274; P78501; Q12842; Q4LE80; Q6NZI3" "Imatinib and chronic myeloid leukemia; Extrafollicular and follicular B cell activation by SARS-CoV-2" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "11" "1" "1.072" "1.042" "1.146" "1.066" "1.060" "1.024" "1.020" "1.031" "1.095" "1140.8" "1222.9" "1188.2" "1307.9" "1215.7" "1209.4" "1167.8" "1163.5" "1176.2" "1249.5" "" "" "" "" "" "" "" "" "" "" "1068.9" "1011.9" "1103.1" "1011.1" "1036.3" "1155.5" "1067.1" "1033.0" "1176.2" "1203.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7100532501288988865" "False" "High" "IsMasterProtein" "P55795" "Heterogeneous nuclear ribonucleoprotein H2 OS=Homo sapiens OX=9606 GN=HNRNPH2 PE=1 SV=1" "0.000" "False" "46.542" "37" "13" "26" "6" "449" "49.2" "6.30" "86.14" "13" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf00076, Pf08080" "3188" "ENSG00000126945" "HNRNPH2" "A1L400; P55795; Q9HHA7" "mRNA processing" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "3" "0" "1.119" "1.021" "1.078" "1.123" "1.051" "0.982" "0.986" "1.040" "1.072" "946.8" "1059.5" "966.3" "1020.7" "1063.8" "994.7" "929.5" "934.0" "984.9" "1015.1" "" "" "" "" "" "" "" "" "" "" "887.2" "876.7" "897.1" "789.0" "906.7" "950.4" "849.3" "829.3" "984.9" "977.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "721169718826189063" "False" "High" "IsMasterProtein" "Q8IX12" "Cell division cycle and apoptosis regulator protein 1 OS=Homo sapiens OX=9606 GN=CCAR1 PE=1 SV=2" "0.000" "False" "46.522" "13" "16" "22" "16" "1150" "132.7" "5.76" "67.09" "16" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf14443, Pf14444, Pf19256, Pf19257" "55749" "ENSG00000060339" "CCAR1" "A0JLT7; A1L4P7; A8K9D4; B4DNP8; B4DRK8; hsa:55749; Q32NE3; Q5EBM3; Q5VUP6; Q6PIZ0; Q6X935; Q8IX12; Q9H8N4; Q9NVA7; Q9NVQ0; Q9NWM6" "" "mRNA Splicing - Major Pathway" "1" "0" "0.996" "1.036" "1.028" "1.064" "1.077" "1.154" "1.181" "1.159" "1.088" "1751.1" "1743.7" "1813.7" "1799.5" "1862.9" "1885.2" "2021.0" "2068.7" "2030.1" "1904.4" "" "" "" "" "" "" "" "" "" "" "1640.8" "1442.9" "1683.8" "1391.1" "1587.9" "1801.1" "1846.7" "1836.8" "2030.1" "1833.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-478504765432675351" "False" "High" "IsMasterProtein" "P30520" "Adenylosuccinate synthetase isozyme 2 OS=Homo sapiens OX=9606 GN=ADSS2 PE=1 SV=3" "0.000" "False" "46.515" "32" "12" "18" "12" "456" "50.1" "6.55" "54.86" "12" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00709" "159" "ENSG00000035687" "ADSS2" "B1AQM5; hsa:159; P30520; Q96EG7" "" "Purine ribonucleoside monophosphate biosynthesis" "1" "0" "0.904" "0.971" "0.917" "0.921" "0.943" "0.866" "0.941" "0.956" "0.902" "1670.0" "1508.9" "1621.6" "1531.5" "1538.4" "1574.2" "1447.0" "1572.0" "1597.0" "1506.5" "" "" "" "" "" "" "" "" "" "" "1564.8" "1248.6" "1505.4" "1184.0" "1311.3" "1504.0" "1322.2" "1395.8" "1597.0" "1450.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4306036841848923980" "False" "High" "IsMasterProtein" "Q08752" "Peptidyl-prolyl cis-trans isomerase D OS=Homo sapiens OX=9606 GN=PPID PE=1 SV=3" "0.000" "False" "46.515" "37" "14" "25" "13" "370" "40.7" "7.21" "81.36" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00160" "5481" "ENSG00000171497" "PPID" "B2R9V2; hsa:5481; Q08752" "Alzheimer's disease and miRNA effects; NO/cGMP/PKG mediated neuroprotection; Alzheimer's disease" "ESR-mediated signaling" "4" "0" "0.989" "0.980" "0.985" "0.979" "1.002" "0.938" "0.981" "0.989" "1.006" "3598.7" "3560.4" "3525.1" "3545.7" "3524.9" "3607.3" "3377.2" "3530.4" "3558.2" "3620.1" "" "" "" "" "" "" "" "" "" "" "3372.0" "2946.2" "3272.6" "2741.0" "3004.5" "3446.5" "3085.8" "3134.6" "3558.2" "3485.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-294736394566280624" "False" "High" "IsMasterProtein" "Q16204" "Coiled-coil domain-containing protein 6 OS=Homo sapiens OX=9606 GN=CCDC6 PE=1 SV=2" "0.000" "False" "46.501" "34" "15" "17" "15" "474" "53.3" "7.34" "56.80" "15" "cell organization and biogenesis" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf09755" "8030" "ENSG00000108091" "CCDC6" "hsa:8030; Q15250; Q16204; Q6GSG7" "Retinoblastoma gene in cancer; Mesodermal commitment pathway; 16p11.2 proximal deletion syndrome" "" "3" "0" "1.042" "1.012" "1.073" "1.069" "1.068" "1.044" "1.044" "1.017" "1.034" "1738.6" "1812.3" "1760.0" "1865.8" "1859.1" "1856.9" "1814.8" "1815.2" "1768.5" "1796.9" "" "" "" "" "" "" "" "" "" "" "1629.1" "1499.6" "1633.9" "1442.3" "1584.7" "1774.1" "1658.3" "1611.7" "1768.5" "1730.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1585817169106109779" "False" "High" "IsMasterProtein" "Q9P2D1" "Chromodomain-helicase-DNA-binding protein 7 OS=Homo sapiens OX=9606 GN=CHD7 PE=1 SV=3" "0.000" "False" "46.499" "6" "18" "20" "13" "2997" "335.7" "6.34" "53.68" "18" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf07533" "55636" "ENSG00000171316" "CHD7" "D0VBA5; E9PNZ2; hsa:55636; Q05DI5; Q2TAN4; Q66K35; Q7Z6C0; Q7Z7Q2; Q9NXA0; Q9NXA3; Q9P2D1" "Kallmann syndrome" "" "1" "3" "1.012" "1.018" "1.051" "1.037" "0.997" "1.028" "0.992" "0.980" "1.026" "1778.7" "1800.4" "1811.5" "1868.8" "1844.6" "1772.6" "1829.2" "1764.2" "1742.5" "1824.4" "" "" "" "" "" "" "" "" "" "" "1666.6" "1489.8" "1681.8" "1444.7" "1572.2" "1693.6" "1671.4" "1566.5" "1742.5" "1756.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7462216625703255168" "False" "High" "IsMasterProtein" "O43847" "Nardilysin OS=Homo sapiens OX=9606 GN=NRDC PE=1 SV=3" "0.000" "False" "46.477" "13" "16" "22" "16" "1151" "131.6" "4.98" "69.17" "16" "protein metabolism;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00675, Pf05193, Pf16187" "4898" "ENSG00000078618" "NRDC" "A6NI41; hsa:4898; O15241; O15242; O43847; Q5VUL0; Q96HB2; Q9NU57" "" "" "0" "0" "0.989" "1.002" "1.015" "1.025" "1.008" "1.046" "1.036" "0.998" "1.015" "1863.1" "1842.3" "1866.9" "1891.9" "1909.1" "1878.4" "1948.9" "1929.9" "1859.1" "1891.3" "" "" "" "" "" "" "" "" "" "" "1745.7" "1524.4" "1733.2" "1462.5" "1627.3" "1794.6" "1780.8" "1713.5" "1859.1" "1821.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6370225409205057848" "False" "High" "IsMasterProtein" "Q9UHX1" "Poly(U)-binding-splicing factor PUF60 OS=Homo sapiens OX=9606 GN=PUF60 PE=1 SV=1" "0.000" "False" "46.472" "31" "13" "22" "13" "559" "59.8" "5.29" "74.37" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "22827" "ENSG00000179950" "PUF60" "A8K8K8; hsa:22827; Q969E7; Q96D94; Q96H63; Q99628; Q9NZA0; Q9UHX1; Q9UJY7" "" "mRNA Splicing - Major Pathway" "1" "0" "1.062" "1.173" "1.100" "1.015" "1.022" "1.121" "1.048" "1.077" "1.101" "1220.1" "1295.3" "1431.1" "1341.6" "1238.1" "1246.7" "1367.3" "1278.3" "1313.7" "1343.3" "" "" "" "" "" "" "" "" "" "" "1143.2" "1071.9" "1328.6" "1037.1" "1055.4" "1191.1" "1249.4" "1135.0" "1313.7" "1293.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2420827179212213562" "False" "High" "IsMasterProtein" "P30622" "CAP-Gly domain-containing linker protein 1 OS=Homo sapiens OX=9606 GN=CLIP1 PE=1 SV=2" "0.000" "False" "46.349" "11" "15" "18" "12" "1438" "162.1" "5.36" "56.20" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf16641" "6249" "ENSG00000130779" "CLIP1" "A0AVD3; hsa:6249; P30622; Q17RS4; Q29RG0" "Microtubule cytoskeleton regulation; PAFAH1B1 copy number variation" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases activate IQGAPs; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "9" "0" "1.031" "1.005" "1.069" "1.067" "1.028" "1.022" "1.042" "1.014" "0.993" "1973.6" "2035.8" "1983.5" "2109.5" "2106.0" "2029.6" "2017.3" "2055.9" "2000.5" "1960.5" "" "" "" "" "" "" "" "" "" "" "1849.3" "1684.6" "1841.5" "1630.7" "1795.1" "1939.1" "1843.2" "1825.4" "2000.5" "1887.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8415712224574136193" "False" "High" "IsMasterProtein" "P26196" "Probable ATP-dependent RNA helicase DDX6 OS=Homo sapiens OX=9606 GN=DDX6 PE=1 SV=2" "0.000" "False" "46.289" "34" "14" "22" "14" "483" "54.4" "8.66" "67.82" "14" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1656" "ENSG00000110367" "DDX6" "hsa:1656; P26196; Q5D048" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "0.983" "1.005" "1.025" "0.994" "1.025" "0.997" "1.032" "0.976" "1.004" "1631.1" "1603.3" "1639.3" "1671.9" "1621.3" "1672.5" "1625.6" "1682.7" "1592.7" "1637.8" "" "" "" "" "" "" "" "" "" "" "1528.4" "1326.7" "1521.9" "1292.5" "1381.9" "1597.9" "1485.4" "1494.0" "1592.7" "1577.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6317068778034787864" "False" "High" "IsMasterProtein" "Q9BTE3" "Mini-chromosome maintenance complex-binding protein OS=Homo sapiens OX=9606 GN=MCMBP PE=1 SV=2" "0.000" "False" "46.228" "22" "14" "19" "14" "642" "72.9" "5.87" "56.47" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09739" "79892" "ENSG00000197771" "MCMBP" "B3KSP7; hsa:79892; Q6IA56; Q9BTE3; Q9BVT9; Q9H916" "" "" "0" "0" "0.984" "1.028" "1.008" "1.013" "1.047" "1.000" "1.033" "1.041" "1.045" "1343.5" "1321.8" "1380.9" "1354.5" "1360.6" "1406.0" "1343.7" "1388.1" "1398.7" "1403.9" "" "" "" "" "" "" "" "" "" "" "1258.8" "1093.7" "1282.0" "1047.1" "1159.7" "1343.3" "1227.7" "1232.5" "1398.7" "1351.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4642544614061212331" "False" "High" "IsMasterProtein" "P38159" "RNA-binding motif protein, X chromosome OS=Homo sapiens OX=9606 GN=RBMX PE=1 SV=3" "0.000" "False" "46.147" "37" "16" "27" "16" "391" "42.3" "10.05" "74.75" "16" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08081" "27316" "ENSG00000147274" "RBMX" "B4E3U4; D3DWH0; E9PG86; hsa:27316; P38159; Q5JQ67; Q8N8Y7; Q969R3" "mRNA processing" "RND2 GTPase cycle; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; RND3 GTPase cycle; RND1 GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "8" "0" "1.086" "1.086" "1.171" "1.155" "1.184" "2.201" "2.350" "2.199" "1.487" "1653.6" "1795.1" "1795.2" "1936.9" "1910.0" "1957.2" "3640.3" "3885.9" "3636.3" "2459.3" "" "" "" "" "" "" "" "" "" "" "1549.4" "1485.4" "1666.6" "1497.3" "1628.1" "1870.0" "3326.3" "3450.3" "3636.3" "2367.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2015286030572761336" "False" "High" "IsMasterProtein" "P24752" "Acetyl-CoA acetyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAT1 PE=1 SV=1" "0.000" "False" "46.072" "29" "12" "23" "12" "427" "45.2" "8.85" "75.80" "12" "other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion;ER/Golgi" "other molecular function" "Pf00108, Pf02803" "38" "ENSG00000075239" "ACAT1" "B2R6H1; G3XAB4; hsa:38; P24752; Q96FG8" "Fatty acid beta-oxidation; Tryptophan metabolism; SARS-CoV-2 and COVID-19 pathway" "Mitochondrial protein degradation; Branched-chain amino acid catabolism; Utilization of Ketone Bodies; Synthesis of Ketone Bodies" "7" "0" "0.924" "0.993" "0.857" "0.949" "0.981" "0.891" "0.996" "0.963" "0.937" "3223.8" "2980.2" "3199.6" "2763.6" "3058.5" "3161.7" "2872.6" "3212.0" "3104.4" "3020.7" "" "" "" "" "" "" "" "" "" "" "3020.7" "2466.1" "2970.5" "2136.4" "2607.0" "3020.7" "2624.8" "2851.9" "3104.4" "2908.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8781846477469752128" "False" "High" "IsMasterProtein" "P38606" "V-type proton ATPase catalytic subunit A OS=Homo sapiens OX=9606 GN=ATP6V1A PE=1 SV=2" "0.000" "False" "46.070" "26" "14" "21" "14" "617" "68.3" "5.52" "61.62" "14" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00006, Pf02874, Pf16886" "523" "ENSG00000114573" "ATP6V1A" "B2RBR8; B7Z1R5; D3DN75; hsa:523; P38606; Q53YD9; Q96DY6; Q9UHY3" "Proximal tubule transport" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "6" "0" "0.923" "0.982" "0.911" "0.959" "0.974" "0.916" "0.973" "0.961" "0.940" "2922.7" "2697.3" "2870.9" "2661.9" "2801.8" "2846.8" "2675.9" "2845.1" "2809.1" "2747.3" "" "" "" "" "" "" "" "" "" "" "2738.6" "2232.0" "2665.3" "2057.8" "2388.2" "2719.9" "2445.1" "2526.2" "2809.1" "2645.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4234558439794556747" "False" "High" "IsMasterProtein" "Q8N6H7" "ADP-ribosylation factor GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=ARFGAP2 PE=1 SV=1" "0.000" "False" "46.049" "29" "14" "16" "14" "521" "56.7" "7.99" "53.77" "14" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf01412" "84364" "ENSG00000149182" "ARFGAP2" "B4DX29; B7Z9M7; D3DQQ9; hsa:84364; Q3LIF2; Q8N3I1; Q8N6H7; Q96SX7" "IL-18 signaling pathway; 5q35 copy number variation" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; CDC42 GTPase cycle" "5" "0" "1.025" "1.032" "0.959" "1.007" "1.003" "0.909" "0.950" "0.921" "0.991" "2268.0" "2325.7" "2341.1" "2174.1" "2284.3" "2274.5" "2061.4" "2155.2" "2088.0" "2247.3" "" "" "" "" "" "" "" "" "" "" "2125.1" "1924.5" "2173.4" "1680.7" "1947.1" "2173.0" "1883.6" "1913.6" "2088.0" "2163.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8716615983158352243" "False" "High" "IsMasterProtein" "P27695" "DNA repair nuclease/redox regulator APEX1 OS=Homo sapiens OX=9606 GN=APEX1 PE=1 SV=2" "0.000" "False" "46.048" "26" "8" "18" "8" "318" "35.5" "8.12" "67.33" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372" "328" "ENSG00000100823; ENSG00000291796" "APEX1" "hsa:328; P27695; Q969L5; Q99775" "Thyroid stimulating hormone (TSH) signaling pathway; Spinal cord injury; Base excision repair; DNA repair pathways, full network" "Displacement of DNA glycosylase by APEX1; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway" "10" "0" "1.128" "0.980" "1.043" "1.009" "0.911" "1.001" "1.021" "1.040" "1.005" "3597.1" "4057.4" "3524.6" "3753.5" "3628.5" "3276.3" "3602.0" "3672.4" "3742.3" "3615.9" "" "" "" "" "" "" "" "" "" "" "3370.4" "3357.4" "3272.2" "2901.6" "3092.8" "3130.2" "3291.2" "3260.7" "3742.3" "3481.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8114162095880212588" "False" "High" "IsMasterProtein" "Q9H3S7" "Tyrosine-protein phosphatase non-receptor type 23 OS=Homo sapiens OX=9606 GN=PTPN23 PE=1 SV=1" "0.000" "False" "46.037" "10" "18" "23" "18" "1636" "178.9" "6.92" "65.33" "18" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00102, Pf03097, Pf13949" "25930" "ENSG00000076201" "PTPN23" "A8K0D7; hsa:25930; Q7KZF8; Q8N6Z5; Q9BSR5; Q9H3S7; Q9P257; Q9UG03; Q9UMZ4" "" "Interleukin-37 signaling" "1" "0" "1.002" "1.010" "1.044" "1.014" "1.052" "1.003" "1.009" "0.993" "1.013" "2053.1" "2057.9" "2073.3" "2143.1" "2082.6" "2159.0" "2059.4" "2071.7" "2038.6" "2080.6" "" "" "" "" "" "" "" "" "" "" "1923.7" "1702.9" "1924.8" "1656.7" "1775.2" "2062.7" "1881.8" "1839.4" "2038.6" "2003.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3418505594273786343" "False" "High" "IsMasterProtein" "P48735" "Isocitrate dehydrogenase [NADP], mitochondrial OS=Homo sapiens OX=9606 GN=IDH2 PE=1 SV=2" "0.000" "False" "46.017" "31" "13" "27" "12" "452" "50.9" "8.69" "82.19" "13" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00180" "3418" "ENSG00000182054" "IDH2" "B2R6L6; B4DFL2; hsa:3418; P48735; Q96GT3" "VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer; Cerebral organic acidurias, including diseases; TCA cycle (aka Krebs or citric acid cycle)" "Transcriptional activation of mitochondrial biogenesis; Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "7" "0" "0.948" "1.001" "0.969" "0.941" "0.954" "0.946" "0.941" "0.907" "0.935" "2540.7" "2407.5" "2542.0" "2461.3" "2389.9" "2423.2" "2404.5" "2391.9" "2303.6" "2376.8" "" "" "" "" "" "" "" "" "" "" "2380.6" "1992.2" "2360.0" "1902.7" "2037.1" "2315.2" "2197.1" "2123.8" "2303.6" "2288.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-658594625945977388" "False" "High" "IsMasterProtein" "O00139" "Kinesin-like protein KIF2A OS=Homo sapiens OX=9606 GN=KIF2A PE=1 SV=3" "0.000" "False" "46.015" "23" "17" "21" "15" "706" "79.9" "6.68" "61.32" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3796" "ENSG00000068796" "KIF2A" "A5YM42; A5YM54; B4DY54; D3DW97; E9PB70; hsa:3796; O00139; Q7Z5I3; Q8N5Q7" "" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "9" "2" "1.039" "1.060" "0.979" "1.028" "1.018" "1.052" "1.065" "1.056" "1.048" "2181.5" "2265.9" "2312.0" "2135.9" "2243.3" "2220.9" "2295.8" "2324.2" "2302.9" "2287.2" "" "" "" "" "" "" "" "" "" "" "2044.1" "1875.0" "2146.4" "1651.1" "1912.1" "2121.8" "2097.7" "2063.7" "2302.9" "2202.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3959098677357932626" "False" "High" "IsMasterProtein" "O43747" "AP-1 complex subunit gamma-1 OS=Homo sapiens OX=9606 GN=AP1G1 PE=1 SV=5" "0.000" "False" "45.944" "18" "17" "25" "16" "822" "91.3" "6.80" "74.64" "17" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf01602, Pf02883" "164" "ENSG00000166747" "AP1G1" "hsa:164; O43747; O75709; O75842; Q9UG09; Q9Y3U4" "" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "4" "1" "0.977" "0.998" "1.009" "1.011" "1.004" "1.013" "0.980" "0.988" "1.003" "3611.9" "3528.9" "3604.5" "3644.7" "3652.1" "3628.1" "3657.3" "3540.6" "3567.7" "3623.9" "" "" "" "" "" "" "" "" "" "" "3384.3" "2920.2" "3346.4" "2817.5" "3112.9" "3466.3" "3341.8" "3143.7" "3567.7" "3489.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6019619507196981202" "False" "High" "IsMasterProtein" "P61158" "Actin-related protein 3 OS=Homo sapiens OX=9606 GN=ACTR3 PE=1 SV=3" "0.000" "False" "45.942" "31" "12" "27" "9" "418" "47.3" "5.88" "86.24" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "10096" "ENSG00000115091" "ACTR3" "hsa:10096; P32391; P61158; Q53QM2" "Physico-chemical features and toxicity-associated pathways" "EPHB-mediated forward signaling; FCGR3A-mediated phagocytosis; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis" "6" "2" "1.009" "1.035" "1.008" "0.982" "0.988" "0.991" "0.967" "1.020" "0.990" "3203.0" "3230.9" "3314.2" "3229.3" "3144.9" "3163.7" "3174.4" "3096.6" "3267.6" "3170.3" "" "" "" "" "" "" "" "" "" "" "3001.2" "2673.6" "3076.8" "2496.4" "2680.6" "3022.6" "2900.5" "2749.5" "3267.6" "3052.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5986296192720168781" "False" "High" "IsMasterProtein" "Q9Y617" "Phosphoserine aminotransferase OS=Homo sapiens OX=9606 GN=PSAT1 PE=1 SV=2" "0.000" "False" "45.931" "37" "14" "25" "14" "370" "40.4" "7.66" "72.03" "14" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00266" "29968" "ENSG00000135069" "PSAT1" "hsa:29968; Q5T7G5; Q5T7G6; Q96AW2; Q9BQ12; Q9Y617" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Male infertility; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "Serine biosynthesis" "7" "0" "1.030" "1.015" "1.021" "1.002" "1.007" "0.922" "0.974" "1.031" "0.983" "2110.6" "2173.9" "2143.2" "2154.4" "2115.8" "2126.2" "1945.6" "2055.8" "2176.2" "2074.3" "" "" "" "" "" "" "" "" "" "" "1977.6" "1798.9" "1989.7" "1665.4" "1803.5" "2031.4" "1777.8" "1825.4" "2176.2" "1997.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5023215591343920566" "False" "High" "IsMasterProtein" "Q12768" "WASH complex subunit 5 OS=Homo sapiens OX=9606 GN=WASHC5 PE=1 SV=1" "0.000" "False" "45.912" "14" "15" "16" "15" "1159" "134.2" "6.98" "50.74" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf10266" "9897" "ENSG00000164961" "WASHC5" "A8K4R7; hsa:9897; Q12768; Q3KQX5; Q8TBQ2" "" "" "0" "0" "0.986" "1.013" "0.976" "1.003" "0.968" "0.933" "0.939" "0.968" "1.007" "1673.4" "1649.5" "1695.7" "1633.3" "1678.3" "1620.6" "1561.6" "1570.6" "1619.7" "1685.3" "" "" "" "" "" "" "" "" "" "" "1568.0" "1365.0" "1574.3" "1262.6" "1430.5" "1548.4" "1426.9" "1394.5" "1619.7" "1622.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9099132526023132947" "False" "High" "IsMasterProtein" "Q9Y6D5" "Brefeldin A-inhibited guanine nucleotide-exchange protein 2 OS=Homo sapiens OX=9606 GN=ARFGEF2 PE=1 SV=3" "0.000" "False" "45.897" "8" "18" "23" "10" "1785" "201.9" "6.33" "66.45" "18" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf01369, Pf09324, Pf12783, Pf16213, Pf20252" "10564" "ENSG00000124198" "ARFGEF2" "hsa:10564; Q5TFT9; Q9NTS1; Q9Y6D5" "" "Association of TriC/CCT with target proteins during biosynthesis" "1" "0" "0.986" "0.995" "1.101" "1.015" "1.006" "0.944" "0.915" "0.907" "1.005" "1381.1" "1361.9" "1373.7" "1521.1" "1401.7" "1389.1" "1303.8" "1264.0" "1253.1" "1387.9" "" "" "" "" "" "" "" "" "" "" "1294.1" "1126.9" "1275.3" "1175.9" "1194.8" "1327.1" "1191.3" "1122.3" "1253.1" "1336.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-175952193399053833" "False" "High" "IsMasterProtein" "P50748" "Kinetochore-associated protein 1 OS=Homo sapiens OX=9606 GN=KNTC1 PE=1 SV=1" "0.000" "False" "45.842" "8" "19" "20" "19" "2209" "250.6" "5.97" "60.08" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10493" "9735" "ENSG00000184445" "KNTC1" "A7E2C4; B3KSG2; hsa:9735; P50748" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.009" "1.009" "1.058" "1.019" "1.006" "1.010" "0.957" "0.957" "1.009" "1565.6" "1579.2" "1579.9" "1657.1" "1595.3" "1575.3" "1581.2" "1498.0" "1497.9" "1579.0" "" "" "" "" "" "" "" "" "" "" "1466.9" "1306.8" "1466.8" "1281.0" "1359.8" "1505.0" "1444.8" "1330.1" "1497.9" "1520.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5272993671693515484" "False" "High" "IsMasterProtein" "Q15181" "Inorganic pyrophosphatase OS=Homo sapiens OX=9606 GN=PPA1 PE=1 SV=2" "0.000" "False" "45.832" "52" "13" "29" "12" "289" "32.6" "5.86" "100.76" "13" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00719" "5464" "ENSG00000180817" "PPA1" "hsa:5464; Q15181; Q2M348; Q5SQT7; Q6P7P4; Q9UQJ5; Q9Y5B1" "" "Cytosolic tRNA aminoacylation; Pyrophosphate hydrolysis" "2" "1" "1.036" "1.014" "1.012" "1.072" "1.044" "1.011" "1.038" "1.089" "1.027" "2111.4" "2187.0" "2140.6" "2136.9" "2262.5" "2205.0" "2134.5" "2192.6" "2299.1" "2168.8" "" "" "" "" "" "" "" "" "" "" "1978.3" "1809.8" "1987.3" "1651.9" "1928.5" "2106.7" "1950.4" "1946.8" "2299.1" "2088.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6733467377289635687" "False" "High" "IsMasterProtein" "Q13838" "Spliceosome RNA helicase DDX39B OS=Homo sapiens OX=9606 GN=DDX39B PE=1 SV=1" "0.000" "False" "45.722" "31" "14" "30" "5" "428" "49.0" "5.67" "96.03" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "7919" "ENSG00000198563; ENSG00000215425; ENSG00000225073; ENSG00000225859; ENSG00000229496; ENSG00000230624; ENSG00000235439" "DDX39B" "B0S8C0; hsa:7919; O43496; Q0EFA1; Q13838; Q2L6F9; Q53GL9; Q5RJ64; Q5RJ66; Q5ST94; Q5STB4; Q5STB5; Q5STB7; Q5STB8; Q5STU4; Q5STU5; Q5STU6; Q5STU8; Q71V76" "" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RHOBTB2 GTPase cycle" "5" "6" "0.959" "1.011" "1.037" "1.042" "1.005" "1.042" "1.059" "1.043" "0.998" "2336.0" "2241.0" "2362.0" "2422.5" "2435.1" "2348.0" "2435.0" "2475.0" "2437.5" "2330.7" "" "" "" "" "" "" "" "" "" "" "2188.8" "1854.4" "2192.8" "1872.7" "2075.6" "2243.3" "2224.9" "2197.5" "2437.5" "2244.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1633285367868477603" "False" "High" "IsMasterProtein" "P35241" "Radixin OS=Homo sapiens OX=9606 GN=RDX PE=1 SV=1" "0.000" "False" "45.658" "23" "16" "26" "5" "583" "68.5" "6.37" "85.38" "16" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "5962" "ENSG00000137710" "RDX" "A7YIJ8; A7YIK0; A7YIK3; B7Z9U6; F5H1A7; hsa:5962; P35241; Q86Y61" "Regulation of actin cytoskeleton" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "4" "1" "0.964" "0.922" "0.895" "0.903" "0.985" "1.005" "0.965" "0.951" "0.944" "852.0" "821.3" "785.4" "762.2" "769.0" "839.5" "856.0" "822.6" "810.3" "804.6" "" "" "" "" "" "" "" "" "" "" "798.4" "679.6" "729.2" "589.2" "655.5" "802.1" "782.1" "730.4" "810.3" "774.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9139942290346830630" "False" "High" "IsMasterProtein" "P30084" "Enoyl-CoA hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ECHS1 PE=1 SV=4" "0.000" "False" "45.585" "41" "11" "24" "11" "290" "31.4" "8.07" "83.95" "11" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00378" "1892" "ENSG00000127884" "ECHS1" "hsa:1892; O00739; P30084; Q5VWY1; Q96H54" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Ciliary landscape; Tryptophan metabolism" "Branched-chain amino acid catabolism; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA" "10" "0" "0.962" "0.980" "0.945" "0.974" "0.984" "0.975" "0.953" "1.012" "0.962" "5924.0" "5697.8" "5804.9" "5596.0" "5770.1" "5826.7" "5773.5" "5643.3" "5997.8" "5701.6" "" "" "" "" "" "" "" "" "" "" "5550.8" "4714.8" "5389.1" "4326.0" "4918.3" "5566.9" "5275.4" "5010.7" "5997.8" "5489.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1011976368699827672" "False" "High" "IsMasterProtein" "P41091" "Eukaryotic translation initiation factor 2 subunit 3 OS=Homo sapiens OX=9606 GN=EIF2S3 PE=1 SV=3" "0.000" "False" "45.562" "29" "13" "24" "13" "472" "51.1" "8.40" "74.42" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144, Pf09173" "1968" "ENSG00000130741" "EIF2S3" "A0A024RBY4; A8K2Y2; B2R5N2; B5BTZ4; hsa:1968; P41091; Q53HK3" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; PKR-mediated signaling; Formation of the ternary complex, and subsequently, the 43S complex; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "14" "0" "0.994" "1.064" "1.052" "1.064" "1.049" "0.987" "1.046" "1.031" "1.059" "2868.1" "2851.7" "3050.9" "3017.9" "3052.8" "3008.0" "2830.7" "2999.2" "2958.2" "3037.9" "" "" "" "" "" "" "" "" "" "" "2687.4" "2359.7" "2832.4" "2333.0" "2602.2" "2873.9" "2586.5" "2663.0" "2958.2" "2925.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3084200639085863850" "False" "High" "IsMasterProtein" "O14497" "AT-rich interactive domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ARID1A PE=1 SV=3" "0.000" "False" "45.554" "7" "14" "16" "14" "2285" "241.9" "6.70" "59.20" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01388, Pf12031" "8289" "ENSG00000117713" "ARID1A" "D3DPL1; hsa:8289; O14497; Q53FK9; Q5T0W1; Q5T0W2; Q5T0W3; Q8NFD6; Q96T89; Q9BY33; Q9HBJ5; Q9UPZ1" "Androgen receptor network in prostate cancer; Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "7" "0" "1.000" "1.038" "0.995" "1.031" "1.017" "0.999" "0.996" "1.012" "1.055" "2562.3" "2563.4" "2659.6" "2549.5" "2642.3" "2606.2" "2559.9" "2552.1" "2593.6" "2703.2" "" "" "" "" "" "" "" "" "" "" "2400.9" "2121.2" "2469.1" "1970.9" "2252.2" "2490.0" "2339.0" "2266.0" "2593.6" "2602.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-216911938682189755" "False" "High" "IsMasterProtein" "Q27J81" "Inverted formin-2 OS=Homo sapiens OX=9606 GN=INF2 PE=1 SV=2" "0.000" "False" "45.516" "13" "15" "20" "15" "1249" "135.5" "5.38" "60.07" "15" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02181, Pf02205, Pf06367, Pf06371" "64423" "ENSG00000203485" "INF2" "hsa:64423; Q27J81; Q27J83; Q69YL8; Q6P1X7; Q6PK22; Q86TR7; Q9BRM1; Q9H6N1" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome" "" "2" "0" "1.037" "0.966" "1.070" "1.056" "1.013" "0.968" "0.955" "0.945" "0.986" "1350.0" "1400.2" "1304.3" "1443.9" "1425.7" "1367.2" "1306.9" "1289.5" "1276.3" "1330.5" "" "" "" "" "" "" "" "" "" "" "1265.0" "1158.7" "1210.9" "1116.2" "1215.2" "1306.2" "1194.1" "1145.0" "1276.3" "1281.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1908270249902800016" "False" "High" "IsMasterProtein" "P35573" "Glycogen debranching enzyme OS=Homo sapiens OX=9606 GN=AGL PE=1 SV=3" "0.000" "False" "45.515" "10" "16" "20" "16" "1532" "174.7" "6.76" "55.23" "16" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06202, Pf14699, Pf14701, Pf14702" "178" "ENSG00000162688" "AGL" "A6NCX7; A6NEK2; D3DT51; hsa:178; P35573; P78354; P78544; Q59H92; Q6AZ90; Q9UF08" "Glycogen synthesis and degradation" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis)" "3" "0" "0.943" "0.956" "0.940" "0.958" "0.959" "0.938" "0.980" "0.928" "0.963" "1869.8" "1764.0" "1787.6" "1757.1" "1791.6" "1793.3" "1753.3" "1831.8" "1735.7" "1801.0" "" "" "" "" "" "" "" "" "" "" "1752.0" "1459.7" "1659.6" "1358.3" "1527.1" "1713.4" "1602.1" "1626.4" "1735.7" "1734.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7719784497129908869" "False" "High" "IsMasterProtein" "O60566" "Mitotic checkpoint serine/threonine-protein kinase BUB1 beta OS=Homo sapiens OX=9606 GN=BUB1B PE=1 SV=3" "0.000" "False" "45.505" "14" "15" "16" "15" "1050" "119.5" "5.27" "46.63" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf08311" "701" "ENSG00000156970" "BUB1B" "B2R6U0; B4DL09; B4DLG3; hsa:701; O60501; O60566; O60627; O60758; O75389; Q59HH6; Q8WV50; Q96KM4" "Regulation of sister chromatid separation at the metaphase-anaphase transition; 10q22q23 copy number variation" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "12" "0" "0.950" "0.958" "0.902" "0.935" "0.931" "0.829" "0.859" "0.843" "0.941" "2730.2" "2594.1" "2615.8" "2463.5" "2553.3" "2542.8" "2262.1" "2344.7" "2302.1" "2568.9" "" "" "" "" "" "" "" "" "" "" "2558.1" "2146.6" "2428.5" "1904.4" "2176.4" "2429.4" "2067.0" "2081.9" "2302.1" "2473.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-16918109513615625" "False" "High" "IsMasterProtein" "P51149" "Ras-related protein Rab-7a OS=Homo sapiens OX=9606 GN=RAB7A PE=1 SV=1" "0.000" "False" "45.499" "53" "9" "18" "9" "207" "23.5" "6.70" "56.58" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "7879" "ENSG00000075785" "RAB7A" "A8K3V6; hsa:7879; P51149; Q9NWJ0; Q9UPB0" "Ebola virus infection in host; Autosomal recessive osteopetrosis pathways; Intracellular trafficking proteins involved in CMT neuropathy" "RHOG GTPase cycle; TBC/RABGAPs; Neutrophil degranulation; Prevention of phagosomal-lysosomal fusion; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; MHC class II antigen presentation; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Suppression of autophagy; RHOH GTPase cycle" "20" "0" "0.954" "0.997" "1.050" "0.920" "0.930" "0.963" "0.942" "0.925" "0.955" "1040.7" "992.4" "1037.5" "1092.9" "957.2" "968.3" "1002.0" "980.7" "962.3" "994.2" "" "" "" "" "" "" "" "" "" "" "975.2" "821.2" "963.2" "844.9" "815.9" "925.2" "915.6" "870.7" "962.3" "957.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4743606762570339993" "False" "High" "IsMasterProtein" "P43403" "Tyrosine-protein kinase ZAP-70 OS=Homo sapiens OX=9606 GN=ZAP70 PE=1 SV=1" "0.000" "False" "45.498" "22" "13" "20" "12" "619" "69.8" "7.69" "63.05" "13" "cell adhesion;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00017, Pf07714" "7535" "ENSG00000115085; ENSG00000291603" "ZAP70" "A6NFP4; P43403; Q6PIA4; Q8IXD6; Q9UBS6" "Prolactin signaling pathway; T cell receptor and co-stimulatory signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Ras signaling; MicroRNA network associated with chronic lymphocytic leukemia; Inflammatory response pathway; Cancer immunotherapy by PD-1 blockade; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis; Interferon type I signaling pathways; T-cell receptor signaling pathway" "Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; RHOH GTPase cycle; Nuclear events stimulated by ALK signaling in cancer" "18" "1" "0.968" "0.977" "0.996" "0.956" "0.990" "0.926" "0.940" "0.947" "0.987" "2069.0" "2003.2" "2021.5" "2059.9" "1978.8" "2047.6" "1915.7" "1943.9" "1960.0" "2042.7" "" "" "" "" "" "" "" "" "" "" "1938.7" "1657.6" "1876.7" "1592.4" "1686.7" "1956.3" "1750.4" "1726.0" "1960.0" "1966.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2641060010654775307" "False" "High" "IsMasterProtein" "O00232" "26S proteasome non-ATPase regulatory subunit 12 OS=Homo sapiens OX=9606 GN=PSMD12 PE=1 SV=3" "0.000" "False" "45.432" "31" "15" "23" "15" "456" "52.9" "7.65" "64.00" "15" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01399, Pf18098" "5718" "ENSG00000197170" "PSMD12" "A6NP15; hsa:5718; O00232; Q53HA2; Q6P053" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "1.026" "0.995" "1.037" "1.000" "0.983" "0.963" "0.974" "1.068" "1.013" "2679.8" "2748.9" "2667.6" "2778.7" "2678.8" "2633.0" "2581.2" "2610.6" "2861.5" "2714.1" "" "" "" "" "" "" "" "" "" "" "2510.9" "2274.7" "2476.5" "2148.1" "2283.4" "2515.6" "2358.6" "2318.0" "2861.5" "2613.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4369524592651400068" "False" "High" "IsMasterProtein" "P43490" "Nicotinamide phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAMPT PE=1 SV=1" "0.000" "False" "45.432" "28" "14" "21" "14" "491" "55.5" "7.15" "65.28" "14" "cell-cell signaling;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04095, Pf18127" "10135" "ENSG00000105835" "NAMPT" "A4D0Q9; A4D0R0; hsa:10135; P43490; Q3KQV0; Q8WW95" "Adipogenesis; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Caloric restriction and aging; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence" "NPAS4 regulates expression of target genes; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nicotinamide salvaging" "9" "0" "0.987" "1.034" "0.999" "0.985" "1.033" "0.970" "0.977" "1.009" "1.081" "1231.8" "1215.6" "1274.0" "1230.0" "1213.1" "1272.9" "1195.0" "1203.6" "1243.4" "1331.7" "" "" "" "" "" "" "" "" "" "" "1154.2" "1005.9" "1182.7" "950.8" "1034.0" "1216.1" "1091.9" "1068.7" "1243.4" "1282.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-537602968940689111" "False" "High" "IsMasterProtein" "P30153" "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R1A PE=1 SV=4" "0.000" "False" "45.322" "23" "14" "33" "12" "589" "65.3" "5.11" "96.36" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02985" "5518" "ENSG00000105568" "PPP2R1A" "hsa:5518; P30153; Q13773; Q6ICQ3; Q96DH3" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "RAF activation; Negative regulation of MAPK pathway; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; PKR-mediated signaling; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "50" "2" "0.975" "0.986" "1.009" "0.947" "0.943" "0.961" "0.941" "0.964" "0.928" "4088.2" "3985.5" "4030.7" "4126.8" "3873.4" "3853.8" "3928.4" "3848.0" "3941.8" "3792.8" "" "" "" "" "" "" "" "" "" "" "3830.6" "3297.9" "3742.0" "3190.2" "3301.6" "3682.0" "3589.5" "3416.6" "3941.8" "3652.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1199984255511246690" "False" "High" "IsMasterProtein" "P85037" "Forkhead box protein K1 OS=Homo sapiens OX=9606 GN=FOXK1 PE=1 SV=1" "0.000" "False" "45.290" "26" "18" "25" "15" "733" "75.4" "9.32" "68.41" "18" "other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf00498" "221937" "ENSG00000164916" "FOXK1" "hsa:221937; P85037" "" "UCH proteinases" "1" "2" "0.975" "0.967" "0.967" "0.954" "0.942" "0.946" "0.946" "0.956" "0.971" "2610.6" "2546.0" "2523.8" "2523.5" "2489.7" "2459.6" "2468.9" "2470.8" "2494.8" "2534.0" "" "" "" "" "" "" "" "" "" "" "2446.1" "2106.8" "2343.0" "1950.8" "2122.1" "2349.9" "2255.9" "2193.9" "2494.8" "2439.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5870318523395655526" "False" "High" "IsMasterProtein" "P49591" "Serine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=SARS1 PE=1 SV=3" "0.000" "False" "45.288" "29" "13" "23" "13" "514" "58.7" "6.43" "74.33" "13" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00587, Pf02403" "6301" "ENSG00000031698" "SARS1" "B2R6Y9; hsa:6301; P49591; Q5T5C8; Q9NSE3" "VEGFA-VEGFR2 signaling" "Cytosolic tRNA aminoacylation; Selenocysteine synthesis" "3" "0" "0.968" "0.980" "0.951" "0.972" "0.980" "0.935" "0.967" "0.914" "0.935" "2521.3" "2440.5" "2470.9" "2396.9" "2450.3" "2470.9" "2356.6" "2438.6" "2303.4" "2356.5" "" "" "" "" "" "" "" "" "" "" "2362.5" "2019.5" "2293.9" "1852.9" "2088.5" "2360.7" "2153.3" "2165.2" "2303.4" "2269.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2550625188107110862" "False" "High" "IsMasterProtein" "P14550" "Aldo-keto reductase family 1 member A1 OS=Homo sapiens OX=9606 GN=AKR1A1 PE=1 SV=3" "0.000" "False" "45.252" "42" "13" "26" "13" "325" "36.6" "6.79" "71.37" "13" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00248" "10327" "ENSG00000117448" "AKR1A1" "A8KAL8; D3DQ04; hsa:10327; P14550; Q6IAZ4" "Benzo(a)pyrene metabolism; Metapathway biotransformation Phase I and II" "Glutathione conjugation; Formation of xylulose-5-phosphate" "4" "0" "0.958" "0.946" "0.931" "0.937" "0.944" "0.933" "0.943" "0.946" "0.910" "1932.1" "1850.8" "1827.9" "1798.8" "1810.8" "1824.2" "1803.3" "1821.9" "1828.4" "1757.3" "" "" "" "" "" "" "" "" "" "" "1810.4" "1531.5" "1697.0" "1390.6" "1543.5" "1742.9" "1647.7" "1617.7" "1828.4" "1692.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5118939103406682552" "False" "High" "IsMasterProtein" "Q8TEX9" "Importin-4 OS=Homo sapiens OX=9606 GN=IPO4 PE=1 SV=2" "0.000" "False" "45.206" "16" "14" "23" "14" "1081" "118.6" "4.96" "65.10" "14" "transport;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03810, Pf13513" "79711" "ENSG00000196497; ENSG00000285248" "IPO4" "B2RN95; hsa:79711; Q2NL96; Q86TZ9; Q8NCG8; Q8TEX9; Q96SJ3; Q9BTI4; Q9H5L0" "" "" "0" "0" "1.045" "1.009" "1.105" "1.078" "1.033" "1.024" "0.995" "1.004" "1.060" "1298.4" "1356.5" "1310.4" "1434.3" "1400.0" "1340.8" "1329.6" "1291.6" "1303.1" "1375.8" "" "" "" "" "" "" "" "" "" "" "1216.6" "1122.5" "1216.6" "1108.8" "1193.3" "1281.0" "1214.9" "1146.8" "1303.1" "1324.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3259776130493618651" "False" "High" "IsMasterProtein" "Q6PI48" "Aspartate--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=DARS2 PE=1 SV=1" "0.000" "False" "45.181" "25" "16" "27" "16" "645" "73.5" "8.02" "82.60" "16" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336, Pf02938" "55157" "ENSG00000117593" "DARS2" "hsa:55157; Q6PI48" "" "Mitochondrial tRNA aminoacylation" "1" "0" "1.018" "1.020" "1.007" "1.022" "1.000" "0.988" "1.007" "0.979" "0.997" "3854.7" "3922.8" "3931.4" "3883.5" "3940.6" "3853.9" "3810.0" "3880.9" "3772.3" "3843.8" "" "" "" "" "" "" "" "" "" "" "3611.8" "3246.1" "3649.8" "3002.1" "3358.9" "3682.1" "3481.3" "3445.9" "3772.3" "3701.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7033934706938727348" "False" "High" "IsMasterProtein" "Q9UNY4" "Transcription termination factor 2 OS=Homo sapiens OX=9606 GN=TTF2 PE=1 SV=2" "0.000" "False" "45.174" "13" "16" "19" "16" "1162" "129.5" "8.37" "65.13" "16" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf06839" "8458" "ENSG00000116830" "TTF2" "A8K4Q2; hsa:8458; O75921; Q5T2K7; Q5VVU8; Q8N6I8; Q9UNY4" "Thyroid stimulating hormone (TSH) signaling pathway; Thyroid hormones production and peripheral downstream signaling effects" "" "2" "0" "0.983" "1.029" "0.962" "0.971" "0.978" "0.878" "0.899" "0.923" "0.979" "2787.5" "2738.7" "2868.5" "2681.1" "2707.9" "2727.0" "2447.3" "2504.6" "2573.7" "2728.5" "" "" "" "" "" "" "" "" "" "" "2611.9" "2266.2" "2663.1" "2072.6" "2308.2" "2605.4" "2236.1" "2223.8" "2573.7" "2627.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5357648313694038384" "False" "High" "IsMasterProtein" "Q8IUD2" "ELKS/Rab6-interacting/CAST family member 1 OS=Homo sapiens OX=9606 GN=ERC1 PE=1 SV=1" "0.000" "False" "45.173" "15" "17" "21" "17" "1116" "128.0" "5.97" "53.22" "17" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf09457, Pf10174" "23085" "ENSG00000082805" "ERC1" "A2RU77; A7E295; D3DUP7; D3DUP8; hsa:23085; Q6NVK2; Q8IUD2; Q8IUD3; Q8IUD4; Q8IUD5; Q8NAS1; Q9NXN5; Q9UIK7; Q9UPS1" "Cell lineage map for neuronal differentiation" "" "1" "0" "1.075" "1.014" "1.067" "1.056" "1.040" "1.050" "1.058" "1.039" "1.060" "1217.0" "1308.6" "1234.6" "1298.0" "1284.6" "1265.6" "1277.4" "1287.8" "1264.6" "1290.3" "" "" "" "" "" "" "" "" "" "" "1140.4" "1082.8" "1146.1" "1003.5" "1095.0" "1209.1" "1167.2" "1143.4" "1264.6" "1242.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4212925493234983848" "False" "High" "IsMasterProtein" "Q14289" "Protein-tyrosine kinase 2-beta OS=Homo sapiens OX=9606 GN=PTK2B PE=1 SV=2" "0.000" "False" "45.134" "18" "17" "19" "17" "1009" "115.8" "6.25" "59.10" "17" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "transporter activity;kinase activity;other molecular function" "Pf00373, Pf03623, Pf07714, Pf18038, Pf21477" "2185" "ENSG00000120899" "PTK2B" "D3DST0; hsa:2185; Q13475; Q14289; Q14290; Q16709; Q6PID4" "IL-7 signaling pathway; Androgen receptor network in prostate cancer; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Hepatocyte growth factor receptor signaling; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-2 signaling pathway; CCL18 signaling pathway; NPHP1 deletion syndrome; 8q11.23 (RB1CC1) copy number variation; HDAC6 interactions in the central nervous system; T-cell receptor signaling pathway" "Interleukin-2 signaling; Signal regulatory protein family interactions; RHOU GTPase cycle; VEGFA-VEGFR2 Pathway" "21" "0" "0.970" "0.987" "0.985" "0.981" "0.963" "0.934" "0.948" "0.923" "0.972" "2882.3" "2796.0" "2844.5" "2838.2" "2827.7" "2774.7" "2693.4" "2731.9" "2659.0" "2802.6" "" "" "" "" "" "" "" "" "" "" "2700.7" "2313.6" "2640.8" "2194.0" "2410.3" "2650.9" "2461.1" "2425.7" "2659.0" "2698.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "868843744032576337" "False" "High" "IsMasterProtein" "P48444" "Coatomer subunit delta OS=Homo sapiens OX=9606 GN=ARCN1 PE=1 SV=1" "0.000" "False" "45.075" "29" "14" "21" "14" "511" "57.2" "6.21" "62.51" "14" "transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf00928, Pf01217" "372" "ENSG00000095139" "ARCN1" "B4E1X2; E9PEU4; hsa:372; P48444; Q52M80" "miR-517 relationship with ARCN1 and USP1" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "3" "0" "0.960" "1.000" "0.982" "1.012" "1.003" "1.020" "0.988" "0.967" "0.982" "2990.4" "2869.8" "2990.8" "2935.3" "3027.4" "2998.0" "3051.1" "2953.2" "2892.7" "2937.6" "" "" "" "" "" "" "" "" "" "" "2802.0" "2374.7" "2776.6" "2269.1" "2580.5" "2864.3" "2787.9" "2622.1" "2892.7" "2828.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4697106387219567458" "False" "High" "IsMasterProtein" "Q6P2E9" "Enhancer of mRNA-decapping protein 4 OS=Homo sapiens OX=9606 GN=EDC4 PE=1 SV=1" "0.000" "False" "44.909" "11" "16" "22" "16" "1401" "151.6" "5.86" "64.28" "16" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf16529, Pf21289" "23644" "ENSG00000038358" "EDC4" "A6NGM1; A8K4T4; hsa:23644; Q13025; Q13826; Q6P2E9; Q6ZR12; Q7Z6H7" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "0.979" "1.031" "1.048" "1.050" "1.057" "1.002" "0.999" "1.003" "1.032" "2300.0" "2250.6" "2370.3" "2409.8" "2414.7" "2430.2" "2304.5" "2297.0" "2306.0" "2374.1" "" "" "" "" "" "" "" "" "" "" "2155.1" "1862.3" "2200.5" "1862.8" "2058.2" "2321.8" "2105.7" "2039.5" "2306.0" "2285.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5232006824815591416" "False" "High" "IsMasterProtein" "P14317" "Hematopoietic lineage cell-specific protein OS=Homo sapiens OX=9606 GN=HCLS1 PE=1 SV=3" "0.000" "False" "44.783" "29" "14" "29" "14" "486" "54.0" "4.81" "97.80" "14" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf02218" "3059" "ENSG00000180353" "HCLS1" "B4DQ69; hsa:3059; P14317; Q53Y93; Q6IBK9; Q9UDK0" "Pathogenic Escherichia coli infection; B cell receptor signaling pathway; TYROBP causal network in microglia" "" "3" "0" "1.074" "1.053" "0.993" "1.020" "1.030" "0.939" "0.996" "1.086" "1.011" "3016.5" "3240.2" "3177.4" "2994.5" "3075.6" "3107.7" "2833.6" "3003.2" "3276.1" "3048.9" "" "" "" "" "" "" "" "" "" "" "2826.4" "2681.3" "2949.8" "2314.9" "2621.6" "2969.1" "2589.2" "2666.5" "3276.1" "2935.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7906499553592381403" "False" "High" "IsMasterProtein" "Q7Z5L9" "Interferon regulatory factor 2-binding protein 2 OS=Homo sapiens OX=9606 GN=IRF2BP2 PE=1 SV=2" "0.000" "False" "44.778" "28" "13" "23" "11" "587" "61.0" "8.69" "85.06" "13" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf11261" "359948" "ENSG00000168264" "IRF2BP2" "B1AM35; B1AM36; hsa:359948; Q6P083; Q7Z5L8; Q7Z5L9; Q8N351; Q8WUH8" "" "" "0" "1" "1.010" "1.011" "1.065" "1.037" "1.014" "0.990" "1.046" "1.063" "1.046" "1961.0" "1981.1" "1981.9" "2088.3" "2033.6" "1989.1" "1940.5" "2051.7" "2084.1" "2050.4" "" "" "" "" "" "" "" "" "" "" "1837.5" "1639.4" "1840.0" "1614.3" "1733.4" "1900.4" "1773.1" "1821.7" "2084.1" "1974.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3313635736816900772" "False" "High" "IsMasterProtein" "O96019" "Actin-like protein 6A OS=Homo sapiens OX=9606 GN=ACTL6A PE=1 SV=1" "0.000" "False" "44.749" "32" "11" "19" "11" "429" "47.4" "5.60" "59.25" "11" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00022" "86" "ENSG00000136518" "ACTL6A" "B3KMN1; D3DNR9; hsa:86; O96019; Q8TAE5; Q9BVS8; Q9H0W6" "Androgen receptor network in prostate cancer; Gastric cancer network 1; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RMTs methylate histone arginines; UCH proteinases; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; HATs acetylate histones; DNA Damage Recognition in GG-NER" "10" "0" "0.956" "1.006" "0.927" "0.939" "0.941" "0.920" "0.965" "0.955" "0.954" "2880.5" "2752.4" "2898.9" "2669.2" "2705.9" "2711.5" "2651.0" "2780.7" "2750.2" "2747.9" "" "" "" "" "" "" "" "" "" "" "2699.0" "2277.6" "2691.3" "2063.4" "2306.4" "2590.6" "2422.3" "2469.0" "2750.2" "2645.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1741293636862823993" "False" "High" "IsMasterProtein" "Q5T1M5" "FK506-binding protein 15 OS=Homo sapiens OX=9606 GN=FKBP15 PE=1 SV=2" "0.000" "False" "44.728" "12" "14" "16" "14" "1219" "133.5" "5.20" "58.31" "14" "transport" "other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00254" "23307" "ENSG00000119321" "FKBP15" "hsa:23307; Q05DK8; Q5T1M2; Q5T1M5; Q6DD85; Q9Y4D0" "TYROBP causal network in microglia" "" "1" "0" "1.012" "1.002" "1.009" "1.038" "1.007" "0.971" "0.957" "0.955" "1.031" "2081.0" "2105.2" "2085.8" "2100.2" "2159.1" "2094.6" "2019.9" "1992.5" "1988.0" "2146.5" "" "" "" "" "" "" "" "" "" "" "1949.9" "1742.0" "1936.4" "1623.6" "1840.4" "2001.2" "1845.6" "1769.1" "1988.0" "2066.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8736083768290238180" "False" "High" "IsMasterProtein" "Cont_P13647" "Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3" "0.000" "True" "44.624" "20" "16" "22" "8" "590" "62.3" "7.74" "60.02" "16" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;cytoskeletal activity;other molecular function" "Pf00038, Pf16208" "3852" "ENSG00000186081" "KRT5" "hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91" "" "Formation of the cornified envelope; Type I hemidesmosome assembly" "3" "1" "0.882" "0.464" "0.609" "0.536" "0.496" "2.101" "0.630" "0.417" "0.703" "1709.8" "1508.7" "792.8" "1041.6" "916.5" "848.6" "3591.8" "1077.4" "712.3" "1202.5" "" "" "" "" "" "" "" "" "" "" "1602.1" "1248.5" "736.0" "805.2" "781.2" "810.7" "3281.9" "956.6" "712.3" "1157.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6836075231128367811" "False" "High" "IsMasterProtein" "Q15008" "26S proteasome non-ATPase regulatory subunit 6 OS=Homo sapiens OX=9606 GN=PSMD6 PE=1 SV=1" "0.000" "False" "44.616" "34" "13" "21" "13" "389" "45.5" "5.62" "74.55" "13" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01399, Pf10602, Pf21154" "9861" "ENSG00000163636" "PSMD6" "A8K2E0; E9PHI9; hsa:9861; Q15008; Q6UV22" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "FCERI mediated NF-kB activation; ABC-family proteins mediated transport; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Neutrophil degranulation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "0.917" "0.960" "0.958" "0.914" "0.920" "0.905" "0.946" "0.890" "0.933" "3611.9" "3311.3" "3467.0" "3459.3" "3301.5" "3322.5" "3268.7" "3416.1" "3214.6" "3370.2" "" "" "" "" "" "" "" "" "" "" "3384.4" "2740.1" "3218.7" "2674.2" "2814.1" "3174.3" "2986.7" "3033.1" "3214.6" "3245.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3480641512252917896" "False" "High" "IsMasterProtein" "Q9NRF8" "CTP synthase 2 OS=Homo sapiens OX=9606 GN=CTPS2 PE=1 SV=1" "0.000" "False" "44.521" "24" "14" "19" "11" "586" "65.6" "6.90" "60.69" "14" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00117, Pf06418, Pf07722" "56474" "ENSG00000047230" "CTPS2" "B3KWM2; hsa:56474; Q9BRI0; Q9H809; Q9H8K9; Q9NRF8" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "0.929" "0.986" "0.971" "0.943" "0.919" "0.947" "0.921" "0.934" "0.937" "1570.6" "1458.4" "1549.3" "1525.2" "1480.5" "1443.4" "1487.1" "1446.9" "1467.6" "1472.4" "" "" "" "" "" "" "" "" "" "" "1471.6" "1206.8" "1438.4" "1179.0" "1261.9" "1379.0" "1358.8" "1284.7" "1467.6" "1417.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5506725299494211183" "False" "High" "IsMasterProtein" "P25786" "Proteasome subunit alpha type-1 OS=Homo sapiens OX=9606 GN=PSMA1 PE=1 SV=1" "0.000" "False" "44.504" "52" "14" "28" "14" "263" "29.5" "6.61" "86.35" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00227, Pf10584" "5682" "ENSG00000129084" "PSMA1" "A8K400; hsa:5682; P25786; Q53YE8; Q9BRV9" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Neddylation; MAPK6/MAPK4 signaling; Antigen processing: Ubiquitination & Proteasome degradation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; UCH proteinases; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.963" "0.981" "0.976" "0.936" "0.982" "0.937" "0.980" "0.979" "0.970" "3767.4" "3629.6" "3695.7" "3677.1" "3527.8" "3699.5" "3529.1" "3692.9" "3689.2" "3652.5" "" "" "" "" "" "" "" "" "" "" "3530.1" "3003.5" "3431.0" "2842.5" "3007.0" "3534.5" "3224.6" "3278.9" "3689.2" "3516.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3504989653461023373" "False" "High" "IsMasterProtein" "P51570" "Galactokinase OS=Homo sapiens OX=9606 GN=GALK1 PE=1 SV=1" "0.000" "False" "44.497" "32" "12" "18" "12" "392" "42.2" "6.46" "63.33" "12" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00288, Pf08544, Pf10509" "2584" "ENSG00000108479" "GALK1" "B2RC07; B4E1G6; hsa:2584; P51570" "Disorders of galactose metabolism" "Galactose catabolism; Defective GALK1 causes GALCT2" "3" "0" "0.994" "0.978" "1.041" "1.021" "0.979" "0.980" "1.000" "0.987" "0.998" "1037.5" "1030.8" "1014.2" "1080.2" "1058.8" "1015.5" "1016.8" "1037.8" "1023.8" "1035.7" "" "" "" "" "" "" "" "" "" "" "972.1" "853.0" "941.5" "835.1" "902.5" "970.2" "929.0" "921.5" "1023.8" "997.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1511141278890819027" "False" "High" "IsMasterProtein" "O14802" "DNA-directed RNA polymerase III subunit RPC1 OS=Homo sapiens OX=9606 GN=POLR3A PE=1 SV=2" "0.000" "False" "44.476" "13" "18" "19" "17" "1390" "155.5" "8.48" "53.86" "18" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04997, Pf04998, Pf05000" "11128" "ENSG00000148606" "POLR3A" "hsa:11128; O14802; Q8IW34; Q8TCW5" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "9" "0" "0.965" "1.044" "1.035" "1.067" "1.011" "0.991" "1.024" "1.047" "1.038" "1453.8" "1403.3" "1518.5" "1505.3" "1551.5" "1469.9" "1440.0" "1488.8" "1521.9" "1509.4" "" "" "" "" "" "" "" "" "" "" "1362.2" "1161.2" "1409.7" "1163.7" "1322.4" "1404.4" "1315.8" "1321.9" "1521.9" "1453.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7212172965787635527" "False" "High" "IsMasterProtein" "Q15031" "Leucine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=LARS2 PE=1 SV=2" "0.000" "False" "44.465" "14" "14" "17" "14" "903" "101.9" "8.22" "49.76" "14" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00133, Pf08264, Pf13603" "23395" "ENSG00000011376" "LARS2" "hsa:23395; Q15031" "Amino acid metabolism; IL-18 signaling pathway; Primary ovarian insufficiency" "Mitochondrial tRNA aminoacylation" "4" "0" "0.985" "1.037" "1.000" "1.013" "1.041" "0.997" "0.986" "1.033" "1.017" "1669.6" "1644.6" "1731.0" "1668.9" "1692.0" "1737.3" "1664.6" "1646.2" "1724.7" "1698.0" "" "" "" "" "" "" "" "" "" "" "1564.4" "1360.9" "1607.1" "1290.1" "1442.2" "1659.8" "1521.0" "1461.7" "1724.7" "1635.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5434950316255047491" "False" "High" "IsMasterProtein" "P42224" "Signal transducer and activator of transcription 1-alpha/beta OS=Homo sapiens OX=9606 GN=STAT1 PE=1 SV=2" "0.000" "False" "44.420" "22" "14" "24" "14" "750" "87.3" "6.05" "70.55" "14" "cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf12162, Pf21354" "6772" "ENSG00000115415" "STAT1" "A8K989; B2RCA0; D2KFR8; D3DPI7; hsa:6772; P42224; Q53S88; Q53XW4; Q68D00; Q9UDL5" "IL-5 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Type III interferon signaling; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Allograft rejection; Interleukin-11 signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Endoderm differentiation; Kit receptor signaling pathway; IL6 signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; p38 MAPK signaling pathway; Immune response to tuberculosis; Ebola virus infection in host; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; IL-10 anti-inflammatory signaling pathway ; Overview of interferons-mediated signaling pathway; Measles virus infection; Tryptophan metabolism; Hepatitis B infection; Endochondral ossification; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; IL-2 signaling pathway; SARS coronavirus and innate immunity; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; CCL18 signaling pathway; Th17 cell differentiation pathway; Inflammatory bowel disease signaling; 2q13 copy number variation syndrome; TROP2 regulatory signaling; IL-26 signaling pathways; JAK-STAT signaling in the regulation of beta cells; IL-19 signaling pathway; TGF-beta receptor signaling; EPO receptor signaling; Interferon type I signaling pathways; Type II interferon signaling; Toll-like receptor signaling pathway" "Growth hormone receptor signaling; PKR-mediated signaling; Interleukin-4 and Interleukin-13 signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Regulation of RUNX2 expression and activity; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signaling by ALK fusions and activated point mutants; Signaling by SCF-KIT; Downstream signal transduction; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Interleukin-6 signaling; Interferon alpha/beta signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; NOTCH3 Intracellular Domain Regulates Transcription; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-27 signaling; Interleukin-9 signaling; Interleukin-21 signaling" "83" "0" "1.009" "0.994" "1.002" "1.034" "1.051" "0.964" "1.016" "0.977" "1.042" "937.0" "945.1" "931.7" "939.1" "969.0" "985.2" "902.8" "952.0" "915.9" "976.3" "" "" "" "" "" "" "" "" "" "" "878.0" "782.1" "865.0" "726.0" "825.9" "941.2" "825.0" "845.3" "915.9" "940.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3497794903438612376" "False" "High" "IsMasterProtein" "Q92541" "RNA polymerase-associated protein RTF1 homolog OS=Homo sapiens OX=9606 GN=RTF1 PE=1 SV=4" "0.000" "False" "44.410" "21" "16" "21" "16" "710" "80.3" "8.15" "60.88" "16" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus" "nucleic acid binding activity" "Pf03126" "23168" "ENSG00000137815" "RTF1" "hsa:23168; Q92541; Q96BX6" "Endoderm differentiation" "RNA Polymerase II Pre-transcription Events; E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex" "5" "0" "0.990" "0.969" "0.916" "0.967" "0.957" "0.957" "0.970" "1.004" "0.983" "2500.4" "2474.2" "2423.9" "2290.4" "2417.5" "2392.0" "2392.1" "2426.4" "2509.8" "2458.8" "" "" "" "" "" "" "" "" "" "" "2342.9" "2047.4" "2250.3" "1770.6" "2060.6" "2285.3" "2185.7" "2154.4" "2509.8" "2367.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5381937792581256012" "False" "High" "IsMasterProtein" "Q9UKW4" "Guanine nucleotide exchange factor VAV3 OS=Homo sapiens OX=9606 GN=VAV3 PE=1 SV=1" "0.000" "False" "44.355" "17" "16" "17" "16" "847" "97.7" "7.05" "51.40" "16" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00130, Pf00169, Pf00307, Pf00621, Pf07653" "10451" "ENSG00000134215" "VAV3" "B1AMM0; B1APV5; B4E232; B7ZLR1; E9PQ97; hsa:10451; O60498; O95230; Q9UKW4; Q9Y5X8" "Integrin-mediated cell adhesion; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mesodermal commitment pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; EGF/EGFR signaling pathway; T-cell receptor signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; FCERI mediated MAPK activation; RAC1 GTPase cycle; NRAGE signals death through JNK; GPVI-mediated activation cascade; DAP12 signaling; EPH-ephrin mediated repulsion of cells; Azathioprine ADME; VEGFR2 mediated vascular permeability; RHOA GTPase cycle; CDC42 GTPase cycle; RHOG GTPase cycle; FCERI mediated Ca+2 mobilization; G alpha (12/13) signalling events; RAC2 GTPase cycle" "26" "0" "0.936" "0.951" "0.955" "0.966" "0.993" "0.932" "0.915" "0.939" "0.952" "2534.8" "2372.0" "2410.4" "2419.5" "2448.6" "2515.9" "2361.7" "2320.1" "2379.5" "2412.9" "" "" "" "" "" "" "" "" "" "" "2375.1" "1962.8" "2237.8" "1870.4" "2087.2" "2403.7" "2157.9" "2060.0" "2379.5" "2323.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3994958122545782914" "False" "High" "IsMasterProtein" "Cont_Q9XSJ4" "Alpha-enolase OS=Bos taurus OX=9913 GN=ENO1 PE=1 SV=4" "0.000" "True" "44.290" "28" "11" "42" "1" "434" "47.3" "6.80" "123.93" "11" "other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00113, Pf03952" "281141" "" "ENO1" "bta:281141; Q3SYW4; Q9XSJ4" "" "" "0" "0" "1.060" "0.834" "1.120" "1.021" "0.882" "1.040" "1.014" "0.979" "0.795" "39.6" "42.0" "33.0" "44.4" "40.4" "34.9" "41.2" "40.2" "38.8" "31.5" "" "" "" "" "" "" "" "" "" "" "37.1" "34.7" "30.7" "34.3" "34.5" "33.4" "37.7" "35.7" "38.8" "30.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8220013005457955452" "False" "High" "IsMasterProtein" "Q15424" "Scaffold attachment factor B1 OS=Homo sapiens OX=9606 GN=SAFB PE=1 SV=4" "0.000" "False" "44.227" "16" "15" "17" "9" "915" "102.6" "5.47" "52.93" "15" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02037" "6294" "ENSG00000160633" "SAFB" "A0AV56; B7Z5B6; B7ZLP6; F5H0H3; hsa:6294; O60406; Q15424; Q59HH8" "Interleukin-1 (IL-1) structural pathway" "SUMOylation of transcription cofactors" "2" "0" "1.131" "1.041" "1.051" "1.040" "1.035" "1.274" "1.399" "1.407" "1.143" "1119.7" "1266.6" "1165.3" "1176.4" "1164.1" "1158.5" "1426.0" "1566.9" "1574.9" "1280.3" "" "" "" "" "" "" "" "" "" "" "1049.2" "1048.1" "1081.8" "909.4" "992.3" "1106.8" "1303.0" "1391.2" "1574.9" "1232.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1246838135834817893" "False" "High" "IsMasterProtein" "O75362" "Zinc finger protein 217 OS=Homo sapiens OX=9606 GN=ZNF217 PE=1 SV=1" "0.000" "False" "44.188" "17" "16" "20" "16" "1048" "115.2" "8.48" "59.60" "16" "other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "7764" "ENSG00000171940" "ZNF217" "E1P5Y6; hsa:7764; O75362; Q14DB8" "" "Estrogen-dependent gene expression" "1" "0" "0.995" "1.016" "0.946" "1.028" "1.043" "0.992" "0.982" "1.008" "0.998" "1153.5" "1147.9" "1171.7" "1091.2" "1185.3" "1203.6" "1144.9" "1132.3" "1162.6" "1151.6" "" "" "" "" "" "" "" "" "" "" "1080.9" "949.9" "1087.8" "843.5" "1010.3" "1150.0" "1046.1" "1005.3" "1162.6" "1108.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2320605404870657198" "False" "High" "IsMasterProtein" "Q8NC51" "SERPINE1 mRNA-binding protein 1 OS=Homo sapiens OX=9606 GN=SERBP1 PE=1 SV=2" "0.000" "False" "44.018" "35" "12" "20" "12" "408" "44.9" "8.65" "67.22" "12" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04774, Pf16174" "26135" "ENSG00000142864" "SERBP1" "hsa:26135; Q5VU19; Q5VU20; Q5VU22; Q8NC51; Q8WUH0; Q96SE2; Q9BTY3; Q9BUM4; Q9Y367; Q9Y4S3" "Apoptosis-related network due to altered Notch3 in ovarian cancer" "" "1" "0" "1.130" "1.045" "1.091" "1.192" "1.186" "1.314" "1.400" "1.270" "1.189" "1474.9" "1666.4" "1540.9" "1608.7" "1757.5" "1748.9" "1938.2" "2064.2" "1872.7" "1753.5" "" "" "" "" "" "" "" "" "" "" "1382.0" "1379.0" "1430.6" "1243.6" "1498.0" "1670.9" "1771.0" "1832.8" "1872.7" "1688.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "412989267492622894" "False" "High" "IsMasterProtein" "Q12874" "Splicing factor 3A subunit 3 OS=Homo sapiens OX=9606 GN=SF3A3 PE=1 SV=1" "0.000" "False" "43.973" "28" "12" "22" "12" "501" "58.8" "5.38" "81.69" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf11931, Pf12108, Pf13297, Pf16837" "10946" "ENSG00000183431" "SF3A3" "D3DPT5; hsa:10946; Q12874; Q15460; Q5VT87" "Exercise-induced circadian regulation; mRNA processing" "mRNA Splicing - Major Pathway" "3" "0" "1.035" "1.033" "1.045" "1.060" "1.104" "1.069" "1.120" "1.128" "1.084" "1805.0" "1868.1" "1864.4" "1885.7" "1912.5" "1993.2" "1930.3" "2021.2" "2036.8" "1957.4" "" "" "" "" "" "" "" "" "" "" "1691.3" "1545.8" "1730.9" "1457.7" "1630.1" "1904.3" "1763.8" "1794.6" "2036.8" "1884.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6716088986514922399" "False" "High" "IsMasterProtein" "Q13617" "Cullin-2 OS=Homo sapiens OX=9606 GN=CUL2 PE=1 SV=2" "0.000" "False" "43.966" "18" "15" "24" "15" "745" "86.9" "6.92" "70.07" "15" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8453" "ENSG00000108094" "CUL2" "B3KT95; B7Z6K8; D3DRY6; G3V1S2; hsa:8453; O00200; Q13617; Q5T2B6; Q9UNF9" "Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2" "Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation" "6" "0" "0.981" "1.033" "0.967" "0.978" "1.006" "0.960" "0.976" "1.037" "1.000" "3515.8" "3448.3" "3633.4" "3400.5" "3438.7" "3535.9" "3374.1" "3430.3" "3645.5" "3514.3" "" "" "" "" "" "" "" "" "" "" "3294.3" "2853.4" "3373.2" "2628.8" "2931.0" "3378.3" "3083.0" "3045.8" "3645.5" "3383.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2229585917492551052" "False" "High" "IsMasterProtein" "P53992" "Protein transport protein Sec24C OS=Homo sapiens OX=9606 GN=SEC24C PE=1 SV=3" "0.000" "False" "43.934" "15" "14" "19" "13" "1094" "118.2" "7.06" "67.70" "14" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "9632" "ENSG00000176986" "SEC24C" "B4DZT4; hsa:9632; P53992; Q8WV25" "Sterol regulatory element-binding proteins (SREBP) signaling" "COPII-mediated vesicle transport; MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "7" "0" "1.002" "1.064" "1.077" "1.052" "1.053" "0.983" "1.031" "1.049" "1.054" "1618.9" "1621.8" "1722.1" "1743.0" "1702.4" "1705.0" "1591.7" "1669.0" "1698.5" "1706.6" "" "" "" "" "" "" "" "" "" "" "1516.9" "1342.0" "1598.7" "1347.4" "1451.1" "1629.0" "1454.4" "1481.9" "1698.5" "1643.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5310524526174993710" "False" "High" "IsMasterProtein" "P51003" "Poly(A) polymerase alpha OS=Homo sapiens OX=9606 GN=PAPOLA PE=1 SV=4" "0.000" "False" "43.906" "21" "12" "20" "12" "745" "82.8" "7.37" "59.16" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04926, Pf04928, Pf20750" "10914" "ENSG00000090060" "PAPOLA" "hsa:10914; P51003; Q86SX4; Q86TV0; Q8IYF5; Q9BVU2" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.079" "1.046" "1.011" "1.314" "1.015" "1.061" "1.015" "1.091" "1.057" "1012.3" "1091.9" "1058.7" "1023.6" "1330.1" "1027.6" "1073.9" "1027.1" "1104.2" "1070.3" "" "" "" "" "" "" "" "" "" "" "948.5" "903.6" "982.8" "791.3" "1133.7" "981.7" "981.2" "912.0" "1104.2" "1030.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8545908257350266971" "False" "High" "IsMasterProtein" "O15144" "Actin-related protein 2/3 complex subunit 2 OS=Homo sapiens OX=9606 GN=ARPC2 PE=1 SV=1" "0.000" "False" "43.903" "41" "13" "22" "13" "300" "34.3" "7.36" "60.58" "13" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf04045" "10109" "ENSG00000163466" "ARPC2" "hsa:10109; O15144; Q92801; Q9P1D4" "Pathogenic Escherichia coli infection" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "6" "0" "0.935" "1.054" "0.958" "0.972" "0.999" "0.942" "1.001" "1.016" "1.012" "1537.8" "1437.5" "1621.1" "1472.8" "1495.3" "1536.4" "1449.3" "1539.6" "1562.2" "1555.7" "" "" "" "" "" "" "" "" "" "" "1440.9" "1189.5" "1505.0" "1138.5" "1274.5" "1467.9" "1324.3" "1367.0" "1562.2" "1497.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2256235105362563928" "False" "High" "IsMasterProtein" "P62937" "Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens OX=9606 GN=PPIA PE=1 SV=2" "0.000" "False" "43.903" "51" "11" "74" "10" "165" "18.0" "7.81" "175.38" "11" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00160" "5478" "ENSG00000196262" "PPIA" "A8K220; hsa:5478; P05092; P62937; Q3KQW3; Q567Q0; Q6IBU5; Q96IX3; Q9BRU4; Q9BTY9; Q9UC61" "Prolactin signaling pathway" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Budding and maturation of HIV virion; Platelet degranulation ; Basigin interactions; SARS-CoV-1 activates/modulates innate immune responses; Integration of provirus; APOBEC3G mediated resistance to HIV-1 infection; Calcineurin activates NFAT; Binding and entry of HIV virion; Assembly Of The HIV Virion; Uncoating of the HIV Virion; Minus-strand DNA synthesis; Plus-strand DNA synthesis" "16" "0" "1.044" "0.966" "1.034" "0.983" "1.072" "0.976" "0.955" "0.980" "1.013" "6393.3" "6674.8" "6178.6" "6609.5" "6284.0" "6851.3" "6242.3" "6106.6" "6263.5" "6475.0" "" "" "" "" "" "" "" "" "" "" "5990.5" "5523.3" "5736.1" "5109.4" "5356.3" "6545.8" "5703.8" "5422.1" "6263.5" "6234.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-877235499680530927" "False" "High" "IsMasterProtein" "Q15366" "Poly(rC)-binding protein 2 OS=Homo sapiens OX=9606 GN=PCBP2 PE=1 SV=1" "0.000" "False" "43.849" "35" "10" "25" "4" "365" "38.6" "6.79" "90.42" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "5094" "ENSG00000197111" "PCBP2" "A8K7X6; B4DXP5; F8VYL7; G3V0E8; hsa:5094; I6L8F9; Q15366; Q32Q82; Q59HD4; Q68Y55; Q6IPF4; Q6PKG5" "mRNA processing; Ferroptosis; Modulators of TCR signaling and T cell activation" "mRNA Splicing - Major Pathway; Negative regulators of DDX58/IFIH1 signaling; Processing of Capped Intron-Containing Pre-mRNA; SARS-CoV-1 activates/modulates innate immune responses" "7" "0" "1.022" "1.020" "1.050" "1.063" "0.997" "1.006" "0.951" "1.161" "1.020" "1131.9" "1157.3" "1154.7" "1188.0" "1203.7" "1128.2" "1138.7" "1076.0" "1314.7" "1154.4" "" "" "" "" "" "" "" "" "" "" "1060.6" "957.6" "1072.0" "918.4" "1026.0" "1077.9" "1040.5" "955.4" "1314.7" "1111.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6639457363078970209" "False" "High" "IsMasterProtein" "P35659" "Protein DEK OS=Homo sapiens OX=9606 GN=DEK PE=1 SV=1" "0.000" "False" "43.692" "32" "13" "25" "13" "375" "42.6" "8.56" "76.78" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf08766" "7913" "ENSG00000124795" "DEK" "B2R6K6; B4DN37; hsa:7913; P35659; Q5TGV4; Q5TGV5" "IL-18 signaling pathway; 10q11.21q11.23 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; Transcriptional regulation of granulopoiesis; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors" "5" "0" "1.048" "1.002" "1.149" "1.084" "1.049" "1.048" "1.146" "1.112" "1.075" "3423.3" "3586.9" "3429.6" "3933.2" "3711.8" "3592.6" "3587.5" "3921.4" "3807.8" "3678.7" "" "" "" "" "" "" "" "" "" "" "3207.6" "2968.1" "3183.9" "3040.5" "3163.9" "3432.4" "3278.0" "3481.8" "3807.8" "3542.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6222929657638767461" "False" "High" "IsMasterProtein" "P23284" "Peptidyl-prolyl cis-trans isomerase B OS=Homo sapiens OX=9606 GN=PPIB PE=1 SV=2" "0.000" "False" "43.666" "55" "13" "31" "12" "216" "23.7" "9.41" "77.82" "13" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00160" "5479" "ENSG00000166794" "PPIB" "A8K534; hsa:5479; P23284; Q6IBH5; Q9BVK5" "Prolactin signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta" "Collagen biosynthesis and modifying enzymes; SARS-CoV-1 activates/modulates innate immune responses" "4" "1" "1.094" "0.978" "1.040" "1.053" "1.175" "0.947" "1.028" "0.992" "1.061" "4277.7" "4679.3" "4182.1" "4447.4" "4505.3" "5026.4" "4051.7" "4397.7" "4244.5" "4538.3" "" "" "" "" "" "" "" "" "" "" "4008.2" "3872.0" "3882.5" "3438.1" "3840.2" "4802.2" "3702.1" "3904.8" "4244.5" "4369.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2598946853791074460" "False" "High" "IsMasterProtein" "Q9Y295" "Developmentally-regulated GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=DRG1 PE=1 SV=1" "0.000" "False" "43.660" "35" "12" "20" "11" "367" "40.5" "8.90" "58.76" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01926, Pf02824, Pf16897" "4733" "ENSG00000185721" "DRG1" "B2RDS8; hsa:4733; Q6FGP8; Q8WW69; Q9UGF2; Q9Y295" "" "Protein hydroxylation" "1" "1" "1.012" "1.007" "0.998" "1.020" "1.014" "0.973" "0.990" "0.975" "0.988" "2255.0" "2282.2" "2271.2" "2250.9" "2300.7" "2287.0" "2194.2" "2231.5" "2198.4" "2227.4" "" "" "" "" "" "" "" "" "" "" "2112.9" "1888.5" "2108.5" "1740.0" "1961.0" "2185.0" "2005.0" "1981.4" "2198.4" "2144.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1108045160068185156" "False" "High" "IsMasterProtein" "P20073" "Annexin A7 OS=Homo sapiens OX=9606 GN=ANXA7 PE=1 SV=3" "0.000" "False" "43.654" "27" "12" "29" "12" "488" "52.7" "5.68" "90.07" "12" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00191" "310" "ENSG00000138279" "ANXA7" "hsa:310; P20073; Q5F2H3; Q5T0M6; Q5T0M7" "" "" "0" "0" "1.010" "1.012" "1.020" "1.025" "1.052" "1.002" "1.045" "1.052" "1.003" "2575.7" "2600.9" "2605.3" "2627.9" "2640.1" "2710.4" "2581.9" "2691.1" "2708.8" "2583.5" "" "" "" "" "" "" "" "" "" "" "2413.4" "2152.2" "2418.7" "2031.5" "2250.4" "2589.5" "2359.2" "2389.4" "2708.8" "2487.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4044629129436372468" "False" "High" "IsMasterProtein" "Q14160" "Protein scribble homolog OS=Homo sapiens OX=9606 GN=SCRIB PE=1 SV=5" "0.000" "False" "43.614" "10" "15" "19" "15" "1630" "174.8" "5.07" "51.81" "15" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00560, Pf00595, Pf13855" "23513" "ENSG00000180900; ENSG00000274287" "SCRIB" "hsa:23513; Q14160; Q6P496; Q7Z5D1; Q8WWV8; Q96C69; Q96GG1" "Thyroid stimulating hormone (TSH) signaling pathway; Complement system in neuronal development and plasticity" "RND2 GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; Asymmetric localization of PCP proteins; RHOJ GTPase cycle; RND3 GTPase cycle" "8" "0" "1.015" "0.995" "1.061" "1.005" "1.012" "1.017" "1.022" "0.992" "1.030" "1399.6" "1421.2" "1392.2" "1484.3" "1406.4" "1416.0" "1423.7" "1430.8" "1388.8" "1440.9" "" "" "" "" "" "" "" "" "" "" "1311.5" "1176.0" "1292.5" "1147.4" "1198.8" "1352.8" "1300.9" "1270.4" "1388.8" "1387.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6199563702112544119" "False" "High" "IsMasterProtein" "Q86XP3" "ATP-dependent RNA helicase DDX42 OS=Homo sapiens OX=9606 GN=DDX42 PE=1 SV=1" "0.000" "False" "43.501" "16" "15" "18" "15" "938" "102.9" "7.02" "54.47" "15" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "11325" "ENSG00000198231" "DDX42" "A6NML1; A8KA43; hsa:11325; O75619; Q68G51; Q86XP3; Q96BK1; Q96HR7; Q9Y3V8" "" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "2" "0" "0.972" "1.011" "0.950" "1.005" "1.024" "1.041" "1.114" "1.124" "1.069" "1784.9" "1734.9" "1804.6" "1696.3" "1793.6" "1827.1" "1857.4" "1987.8" "2006.6" "1907.4" "" "" "" "" "" "" "" "" "" "" "1672.5" "1435.6" "1675.4" "1311.3" "1528.8" "1745.7" "1697.2" "1765.0" "2006.6" "1836.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1051331415144919391" "False" "High" "IsMasterProtein" "P49189" "4-trimethylaminobutyraldehyde dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH9A1 PE=1 SV=3" "0.000" "False" "43.480" "27" "12" "21" "12" "494" "53.8" "5.87" "65.99" "12" "cell organization and biogenesis;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00171" "223" "ENSG00000143149" "ALDH9A1" "B2R6X1; B4DXY7; B9EKV4; hsa:223; P49189; Q5VV90; Q6LCL1; Q9NZT7" "GABA receptor signaling; Fluoroacetic acid toxicity; Opioid receptor pathways" "Carnitine synthesis" "4" "0" "0.953" "0.973" "0.975" "0.945" "0.931" "0.933" "0.927" "0.948" "0.913" "2394.3" "2281.9" "2330.4" "2334.2" "2262.7" "2228.1" "2233.5" "2219.3" "2269.9" "2185.9" "" "" "" "" "" "" "" "" "" "" "2243.4" "1888.2" "2163.5" "1804.4" "1928.7" "2128.8" "2040.8" "1970.5" "2269.9" "2104.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-767357545140157834" "False" "High" "IsMasterProtein" "P51784" "Ubiquitin carboxyl-terminal hydrolase 11 OS=Homo sapiens OX=9606 GN=USP11 PE=1 SV=3" "0.000" "False" "43.463" "13" "13" "22" "12" "963" "109.7" "5.45" "59.47" "13" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf06337, Pf14533, Pf14836" "" "ENSG00000102226" "USP11" "B2RTX1; P51784; Q8IUG6; Q9BWE1" "" "Ub-specific processing proteases; Association of TriC/CCT with target proteins during biosynthesis" "2" "0" "1.074" "0.976" "1.057" "1.032" "1.016" "1.013" "0.890" "0.941" "1.002" "1306.2" "1402.5" "1275.3" "1380.7" "1348.4" "1327.6" "1322.9" "1161.9" "1228.6" "1308.2" "" "" "" "" "" "" "" "" "" "" "1223.9" "1160.5" "1184.0" "1067.3" "1149.3" "1268.4" "1208.8" "1031.7" "1228.6" "1259.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3232925650926593770" "False" "High" "IsMasterProtein" "Q9C0C2" "182 kDa tankyrase-1-binding protein OS=Homo sapiens OX=9606 GN=TNKS1BP1 PE=1 SV=4" "0.000" "False" "43.462" "8" "14" "18" "14" "1729" "181.7" "4.86" "53.82" "14" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15327" "85456" "ENSG00000149115" "TNKS1BP1" "A7E2F8; hsa:85456; Q6PJ35; Q6ZV74; Q9C0C2" "Ciliary landscape" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "4" "0" "1.053" "1.041" "1.040" "1.077" "1.101" "1.136" "1.114" "1.178" "1.086" "569.8" "600.0" "593.1" "592.8" "613.4" "627.5" "647.1" "634.6" "671.4" "619.0" "" "" "" "" "" "" "" "" "" "" "533.9" "496.5" "550.7" "458.3" "522.8" "599.5" "591.2" "563.5" "671.4" "596.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5190108194104216904" "False" "High" "IsMasterProtein" "O43615" "Mitochondrial import inner membrane translocase subunit TIM44 OS=Homo sapiens OX=9606 GN=TIMM44 PE=1 SV=2" "0.000" "False" "43.440" "30" "13" "17" "13" "452" "51.3" "8.32" "62.78" "13" "transport;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf04280" "10469" "ENSG00000104980" "TIMM44" "A8K0R9; D6W664; hsa:10469; O43615; Q8N193" "" "Mitochondrial protein import" "1" "0" "1.022" "0.998" "0.954" "1.076" "1.070" "1.017" "0.965" "0.997" "1.034" "1392.4" "1423.6" "1389.4" "1328.5" "1498.4" "1490.2" "1415.7" "1344.0" "1388.7" "1439.7" "" "" "" "" "" "" "" "" "" "" "1304.7" "1178.0" "1289.9" "1027.0" "1277.2" "1423.7" "1293.6" "1193.3" "1388.7" "1386.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9117117300834082613" "False" "High" "IsMasterProtein" "Q9H5N1" "Rab GTPase-binding effector protein 2 OS=Homo sapiens OX=9606 GN=RABEP2 PE=1 SV=2" "0.000" "False" "43.439" "21" "13" "16" "13" "569" "63.5" "4.78" "55.16" "13" "cell organization and biogenesis;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf03528, Pf09311" "79874" "ENSG00000177548" "RABEP2" "hsa:79874; Q9H5N1" "Ciliary landscape; 16p11.2 distal deletion syndrome" "" "2" "0" "1.094" "0.984" "1.112" "1.065" "1.085" "0.994" "0.951" "1.027" "1.063" "749.9" "820.5" "737.5" "834.1" "798.8" "813.8" "745.0" "712.9" "770.1" "797.1" "" "" "" "" "" "" "" "" "" "" "702.6" "678.9" "684.7" "644.8" "680.9" "777.5" "680.7" "632.9" "770.1" "767.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4143955501491186019" "False" "High" "IsMasterProtein" "P55084" "Trifunctional enzyme subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=HADHB PE=1 SV=3" "0.000" "False" "43.420" "29" "12" "17" "12" "474" "51.3" "9.41" "53.24" "12" "other metabolic processes;other biological processes" "other membranes;mitochondrion;ER/Golgi" "nucleic acid binding activity;other molecular function" "Pf00108, Pf02803" "3032" "ENSG00000138029" "HADHB" "B2RB16; B4E2W0; hsa:3032; O14969; P55084; Q53TA6; Q96C77; Q9H3F5; Q9T2V8" "Fatty acid beta-oxidation; Valproic acid pathway; Female steroid hormones in cardiomyocyte energy metabolism; Sudden infant death syndrome (SIDS) susceptibility pathways" "Acyl chain remodeling of CL; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "12" "0" "1.020" "1.083" "0.959" "1.050" "1.082" "0.973" "1.044" "1.048" "1.023" "946.4" "965.4" "1024.7" "907.4" "993.7" "1023.7" "920.9" "987.6" "992.2" "968.0" "" "" "" "" "" "" "" "" "" "" "886.7" "798.9" "951.3" "701.4" "847.0" "978.0" "841.5" "876.9" "992.2" "932.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7388585802174213380" "False" "High" "IsMasterProtein" "Q06187" "Tyrosine-protein kinase BTK OS=Homo sapiens OX=9606 GN=BTK PE=1 SV=3" "0.000" "False" "43.376" "20" "13" "19" "13" "659" "76.2" "7.77" "62.23" "13" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf00169, Pf00779, Pf07714" "695" "ENSG00000010671" "BTK" "B2RAW1; hsa:695; Q06187; Q32ML5" "IL-5 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; Kit receptor signaling pathway; 7q11.23 copy number variation syndrome; Genetic causes of porto-sinusoidal vascular disease" "FCGR3A-mediated phagocytosis; ER-Phagosome pathway; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated Ca+2 mobilization; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; G alpha (12/13) signalling events; G alpha (q) signalling events; RHO GTPases Activate WASPs and WAVEs; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); DAP12 signaling; G beta:gamma signalling through BTK" "20" "0" "0.939" "1.029" "0.985" "0.981" "0.988" "0.920" "0.924" "0.934" "0.994" "4653.2" "4368.9" "4786.1" "4585.2" "4565.8" "4598.1" "4281.5" "4298.5" "4346.7" "4625.9" "" "" "" "" "" "" "" "" "" "" "4360.0" "3615.2" "4443.3" "3544.6" "3891.8" "4393.0" "3912.1" "3816.6" "4346.7" "4454.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1873273852874603797" "False" "High" "IsMasterProtein" "Q709C8" "Intermembrane lipid transfer protein VPS13C OS=Homo sapiens OX=9606 GN=VPS13C PE=1 SV=1" "0.000" "False" "43.337" "4" "15" "16" "15" "3753" "422.1" "6.83" "48.64" "15" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf06650, Pf09333, Pf12624, Pf16908, Pf16909, Pf16910, Pf21679" "54832" "ENSG00000129003" "VPS13C" "hsa:54832; Q6ISR4; Q702P2; Q702P3; Q709C8; Q709C9; Q9NXN8; Q9P2C6" "" "" "0" "0" "1.002" "0.948" "1.034" "1.094" "1.014" "1.084" "1.059" "1.056" "1.044" "1968.8" "1973.5" "1867.2" "2036.3" "2154.4" "1996.3" "2134.6" "2084.5" "2079.9" "2056.1" "" "" "" "" "" "" "" "" "" "" "1844.8" "1633.0" "1733.4" "1574.2" "1836.3" "1907.2" "1950.5" "1850.8" "2079.9" "1979.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4087674429968217888" "False" "High" "IsMasterProtein" "P63010" "AP-2 complex subunit beta OS=Homo sapiens OX=9606 GN=AP2B1 PE=1 SV=1" "0.000" "False" "43.284" "16" "15" "24" "7" "937" "104.5" "5.38" "73.65" "15" "transport;developmental processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02883, Pf09066" "163" "ENSG00000006125" "AP2B1" "A6NJP3; hsa:163; P21851; P63010; Q7Z451; Q96J19" "Synaptic vesicle pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission; Markers of kidney cell lineage; 17q12 copy number variation syndrome" "MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; Potential therapeutics for SARS; Recycling pathway of L1; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "20" "6" "0.969" "1.061" "1.000" "1.021" "1.060" "1.015" "1.033" "1.051" "1.020" "3457.8" "3350.2" "3669.2" "3459.2" "3532.0" "3666.4" "3510.2" "3573.6" "3635.5" "3527.9" "" "" "" "" "" "" "" "" "" "" "3240.0" "2772.3" "3406.4" "2674.1" "3010.6" "3502.9" "3207.4" "3173.0" "3635.5" "3396.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2244898098371361519" "False" "High" "IsMasterProtein" "Q86VS8" "Protein Hook homolog 3 OS=Homo sapiens OX=9606 GN=HOOK3 PE=1 SV=2" "0.000" "False" "43.217" "19" "15" "21" "15" "718" "83.1" "5.17" "62.43" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf05622, Pf19047" "84376" "ENSG00000168172" "HOOK3" "D3DSY8; hsa:84376; Q86VS8; Q8NBH0; Q9BY13" "" "" "0" "0" "1.065" "1.051" "1.030" "1.063" "1.068" "1.057" "0.978" "0.945" "1.026" "1279.2" "1362.8" "1343.8" "1318.1" "1359.4" "1365.6" "1351.5" "1251.5" "1208.7" "1312.1" "" "" "" "" "" "" "" "" "" "" "1198.6" "1127.7" "1247.5" "1019.0" "1158.7" "1304.7" "1234.9" "1111.2" "1208.7" "1263.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8070677658803742602" "False" "High" "IsMasterProtein" "P20585" "DNA mismatch repair protein Msh3 OS=Homo sapiens OX=9606 GN=MSH3 PE=1 SV=4" "0.000" "False" "43.203" "12" "13" "14" "13" "1137" "127.3" "8.02" "47.82" "13" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00488, Pf01624, Pf05188, Pf05192" "4437" "ENSG00000113318" "MSH3" "A1L480; A1L482; A6NMM6; hsa:4437; P20585; Q6PJT5; Q86UQ6; Q92867" "Chromosomal and microsatellite instability in colorectal cancer ; DNA repair pathways, full network" "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2" "5" "0" "1.001" "1.013" "1.023" "1.020" "0.972" "1.048" "0.943" "0.969" "1.026" "1152.7" "1153.3" "1167.5" "1179.3" "1175.8" "1120.8" "1208.0" "1086.6" "1116.5" "1182.9" "" "" "" "" "" "" "" "" "" "" "1080.1" "954.4" "1083.9" "911.7" "1002.2" "1070.8" "1103.8" "964.8" "1116.5" "1139.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4733081690105890722" "False" "High" "IsMasterProtein" "Q9UKN8" "General transcription factor 3C polypeptide 4 OS=Homo sapiens OX=9606 GN=GTF3C4 PE=1 SV=2" "0.000" "False" "43.194" "20" "14" "24" "14" "822" "91.9" "6.65" "65.18" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf12657, Pf12660, Pf19336" "9329" "ENSG00000125484" "GTF3C4" "hsa:9329; Q5VZJ7; Q9UKN8" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "3" "0" "0.994" "1.023" "1.111" "1.002" "1.031" "1.009" "0.996" "0.965" "1.000" "1597.9" "1589.1" "1635.3" "1775.0" "1601.8" "1647.7" "1613.1" "1591.9" "1542.4" "1597.4" "" "" "" "" "" "" "" "" "" "" "1497.3" "1315.0" "1518.2" "1372.1" "1365.3" "1574.2" "1473.9" "1413.4" "1542.4" "1538.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2163956888383823018" "False" "High" "IsMasterProtein" "Q96A65" "Exocyst complex component 4 OS=Homo sapiens OX=9606 GN=EXOC4 PE=1 SV=1" "0.000" "False" "43.067" "16" "14" "16" "14" "974" "110.4" "6.49" "52.10" "14" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf04048, Pf20652" "60412" "ENSG00000131558" "EXOC4" "E9PED2; hsa:60412; Q541U8; Q96A65; Q9C0G4; Q9H9K0; Q9P102" "Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "4" "0" "0.954" "1.007" "0.957" "1.009" "0.977" "0.915" "0.931" "0.962" "1.019" "2605.8" "2485.4" "2625.2" "2494.1" "2629.7" "2545.2" "2385.1" "2425.2" "2506.5" "2654.0" "" "" "" "" "" "" "" "" "" "" "2441.7" "2056.6" "2437.2" "1928.1" "2241.5" "2431.7" "2179.4" "2153.3" "2506.5" "2555.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2859585786570282431" "False" "High" "IsMasterProtein" "P08237" "ATP-dependent 6-phosphofructokinase, muscle type OS=Homo sapiens OX=9606 GN=PFKM PE=1 SV=2" "0.000" "False" "43.061" "22" "15" "21" "12" "780" "85.1" "7.99" "64.91" "15" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "kinase activity;other molecular function" "Pf00365" "5213" "ENSG00000152556" "PFKM" "hsa:5213; J3KNX3; P08237; Q16814; Q16815; Q6ZTT1" "Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Insulin signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis" "6" "0" "1.003" "1.015" "1.042" "0.988" "0.988" "1.003" "0.956" "0.951" "0.937" "1459.7" "1464.7" "1481.0" "1521.0" "1441.9" "1442.5" "1464.1" "1394.8" "1388.4" "1368.4" "" "" "" "" "" "" "" "" "" "" "1367.7" "1212.0" "1375.0" "1175.8" "1229.0" "1378.1" "1337.8" "1238.5" "1388.4" "1317.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4495210949063335174" "False" "High" "IsMasterProtein" "Q7L576" "Cytoplasmic FMR1-interacting protein 1 OS=Homo sapiens OX=9606 GN=CYFIP1 PE=1 SV=1" "0.000" "False" "43.042" "12" "14" "17" "4" "1253" "145.1" "6.90" "51.85" "14" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf05994, Pf07159" "23191" "ENSG00000273749; ENSG00000288461" "CYFIP1" "A8K6D9; hsa:23191; Q14467; Q5IED0; Q6ZSX1; Q7L576; Q9BSD9; Q9BVC7" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Prader-Willi and Angelman syndrome; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; 15q11.2 copy number variation syndrome; G13 signaling pathway" "Neutrophil degranulation; VEGFA-VEGFR2 Pathway; RAC1 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHOG GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle" "15" "0" "1.242" "1.197" "1.304" "1.218" "1.115" "1.151" "1.315" "1.120" "1.155" "63.6" "79.0" "76.2" "83.0" "77.5" "70.9" "73.2" "83.7" "71.3" "73.5" "" "" "" "" "" "" "" "" "" "" "59.6" "65.4" "70.7" "64.1" "66.0" "67.8" "66.9" "74.3" "71.3" "70.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3079074271338885879" "False" "High" "IsMasterProtein" "P16403" "Histone H1.2 OS=Homo sapiens OX=9606 GN=H1-2 PE=1 SV=2" "0.000" "False" "43.015" "39" "11" "23" "4" "213" "21.4" "10.93" "79.54" "11" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3006" "ENSG00000187837" "H1-2" "A8K4I2; hsa:3006; P16403" "" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "2" "7" "1.093" "1.073" "0.901" "1.030" "0.976" "0.994" "1.014" "0.996" "0.979" "3080.2" "3366.1" "3304.2" "2775.1" "3172.3" "3007.2" "3062.6" "3123.9" "3067.2" "3015.2" "" "" "" "" "" "" "" "" "" "" "2886.1" "2785.4" "3067.6" "2145.3" "2703.9" "2873.1" "2798.4" "2773.7" "3067.2" "2903.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5285928462194255524" "False" "High" "IsMasterProtein" "Q9H6T3" "RNA polymerase II-associated protein 3 OS=Homo sapiens OX=9606 GN=RPAP3 PE=1 SV=2" "0.000" "False" "43.014" "23" "14" "17" "14" "665" "75.7" "6.84" "54.31" "14" "other biological processes" "cytosol;other cell component" "" "Pf00515, Pf13181, Pf13877" "79657" "ENSG00000005175" "RPAP3" "B4DRW9; hsa:79657; Q6PHR5; Q9H6T3" "" "" "0" "0" "0.957" "1.010" "0.995" "0.992" "0.993" "0.974" "0.965" "0.983" "1.010" "1945.8" "1862.4" "1964.8" "1935.2" "1930.5" "1932.7" "1896.0" "1877.9" "1912.6" "1965.4" "" "" "" "" "" "" "" "" "" "" "1823.2" "1541.1" "1824.0" "1496.0" "1645.5" "1846.5" "1732.5" "1667.4" "1912.6" "1892.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5359713146649655482" "False" "High" "IsMasterProtein" "P31150" "Rab GDP dissociation inhibitor alpha OS=Homo sapiens OX=9606 GN=GDI1 PE=1 SV=2" "0.000" "False" "42.933" "34" "12" "17" "7" "447" "50.6" "5.14" "51.11" "12" "cell organization and biogenesis;transport;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "2664" "ENSG00000203879" "GDI1" "hsa:2664; P31150; P50394; Q6FG50; Q7Z2G6; Q7Z2G9; Q7Z2H5; Q7Z2I6" "Ciliary landscape; Airway smooth muscle cell contraction" "RAB GEFs exchange GTP for GDP on RABs" "3" "0" "0.985" "0.923" "1.070" "0.991" "1.010" "1.005" "0.974" "0.987" "0.979" "447.2" "440.5" "413.0" "478.4" "443.1" "451.7" "449.2" "435.5" "441.2" "437.6" "" "" "" "" "" "" "" "" "" "" "419.0" "364.5" "383.4" "369.8" "377.7" "431.5" "410.5" "386.7" "441.2" "421.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6980948205033410350" "False" "High" "IsMasterProtein" "Q8WXI9" "Transcriptional repressor p66-beta OS=Homo sapiens OX=9606 GN=GATAD2B PE=1 SV=1" "0.000" "False" "42.916" "27" "15" "16" "15" "593" "65.2" "9.70" "48.84" "15" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00320, Pf16563" "57459" "ENSG00000143614; ENSG00000261992" "GATAD2B" "D3DUZ2; hsa:57459; Q5VUR2; Q7LG68; Q8WXI9; Q9ULS0" "" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "6" "0" "1.008" "1.017" "0.912" "1.003" "0.959" "0.893" "0.942" "0.942" "1.019" "2408.7" "2429.1" "2448.6" "2196.7" "2417.1" "2309.2" "2152.1" "2268.5" "2268.9" "2454.0" "" "" "" "" "" "" "" "" "" "" "2256.9" "2010.0" "2273.2" "1698.2" "2060.2" "2206.2" "1966.5" "2014.2" "2268.9" "2362.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5021829867861972309" "False" "High" "IsMasterProtein" "Q14671" "Pumilio homolog 1 OS=Homo sapiens OX=9606 GN=PUM1 PE=1 SV=3" "0.000" "False" "42.885" "12" "14" "18" "10" "1186" "126.4" "6.84" "51.92" "14" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00806" "9698" "ENSG00000134644" "PUM1" "A8K6W4; B4DG92; D3DPN3; E9PCJ0; hsa:9698; Q14671; Q53HH5; Q5VXY7; Q9HAN1" "" "Golgi Associated Vesicle Biogenesis" "1" "2" "0.968" "1.015" "0.943" "1.008" "1.021" "0.930" "0.937" "0.905" "0.974" "2579.0" "2496.1" "2618.3" "2430.9" "2600.9" "2634.2" "2398.9" "2416.9" "2334.4" "2513.1" "" "" "" "" "" "" "" "" "" "" "2416.5" "2065.5" "2430.7" "1879.2" "2216.9" "2516.7" "2192.0" "2145.9" "2334.4" "2419.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2799145337949175211" "False" "High" "IsMasterProtein" "O15294" "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Homo sapiens OX=9606 GN=OGT PE=1 SV=3" "0.000" "False" "42.861" "12" "14" "17" "14" "1046" "116.9" "6.70" "50.44" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00515, Pf13181, Pf13414, Pf13424, Pf13844" "8473" "ENSG00000147162" "OGT" "hsa:8473; O15294; Q7Z3K0; Q8WWM8; Q96CC1; Q9UG57" "Ectoderm differentiation; Ectoderm differentiation; Pleural mesothelioma" "UCH proteinases; Formation of WDR5-containing histone-modifying complexes; Regulation of necroptotic cell death; HATs acetylate histones" "8" "0" "0.973" "0.996" "1.004" "1.005" "1.004" "0.973" "0.991" "1.025" "1.012" "3068.3" "2984.6" "3057.2" "3081.8" "3084.5" "3080.4" "2985.6" "3039.4" "3144.7" "3103.8" "" "" "" "" "" "" "" "" "" "" "2875.0" "2469.7" "2838.3" "2382.4" "2629.2" "2943.1" "2728.1" "2698.7" "3144.7" "2988.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5053375512568543969" "False" "High" "IsMasterProtein" "Q0VDF9" "Heat shock 70 kDa protein 14 OS=Homo sapiens OX=9606 GN=HSPA14 PE=1 SV=1" "0.000" "False" "42.852" "26" "13" "19" "13" "509" "54.8" "5.59" "54.01" "13" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00012" "51182" "ENSG00000187522" "HSPA14" "A8K8F8; B0YIY9; hsa:51182; Q0VDF9; Q9P0X2; Q9UI07" "Parkin-ubiquitin proteasomal system pathway" "Regulation of HSF1-mediated heat shock response" "2" "0" "1.014" "0.976" "0.969" "0.975" "0.960" "0.965" "0.880" "0.949" "0.943" "2767.9" "2808.0" "2700.3" "2682.7" "2700.0" "2656.5" "2670.6" "2434.8" "2626.8" "2609.9" "" "" "" "" "" "" "" "" "" "" "2593.5" "2323.6" "2506.9" "2073.8" "2301.5" "2538.0" "2440.2" "2161.8" "2626.8" "2513.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6919500497101416540" "False" "High" "IsMasterProtein" "Q9UJU6" "Drebrin-like protein OS=Homo sapiens OX=9606 GN=DBNL PE=1 SV=1" "0.000" "False" "42.837" "32" "11" "18" "11" "430" "48.2" "5.05" "72.09" "11" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241, Pf14604" "28988" "ENSG00000136279" "DBNL" "A4D2I9; B4DDP6; B4DEM2; C9J7P1; hsa:28988; P84070; Q6IAI8; Q96F30; Q96K74; Q9HBN8; Q9NR72; Q9UJU6" "T-cell receptor signaling pathway" "Neutrophil degranulation; Neurexins and neuroligins; Caspase-mediated cleavage of cytoskeletal proteins" "4" "0" "0.993" "0.991" "1.008" "0.995" "0.970" "0.993" "0.980" "0.958" "0.990" "2209.0" "2192.8" "2189.2" "2226.6" "2198.6" "2142.3" "2194.1" "2165.4" "2116.4" "2186.5" "" "" "" "" "" "" "" "" "" "" "2069.9" "1814.5" "2032.3" "1721.3" "1874.0" "2046.7" "2004.8" "1922.6" "2116.4" "2105.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832137807520605002" "False" "High" "IsMasterProtein" "O60934" "Nibrin OS=Homo sapiens OX=9606 GN=NBN PE=1 SV=1" "0.000" "False" "42.784" "21" "14" "15" "14" "754" "84.9" "6.90" "50.45" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00498, Pf00533, Pf08599, Pf16508" "4683" "ENSG00000104320" "NBN" "B2R626; B2RNC5; hsa:4683; O60672; O60934; Q32NF7; Q53FM6; Q63HR6; Q7LDM2" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Primary ovarian insufficiency; DNA damage response" "Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks" "29" "0" "1.041" "1.018" "0.971" "1.022" "0.981" "0.993" "0.992" "0.986" "1.022" "2203.7" "2293.0" "2243.7" "2140.6" "2252.7" "2162.2" "2189.0" "2186.2" "2173.2" "2251.7" "" "" "" "" "" "" "" "" "" "" "2064.9" "1897.4" "2083.0" "1654.8" "1920.1" "2065.8" "2000.2" "1941.1" "2173.2" "2168.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6692075332981007833" "False" "High" "IsMasterProtein" "Q13451" "Peptidyl-prolyl cis-trans isomerase FKBP5 OS=Homo sapiens OX=9606 GN=FKBP5 PE=1 SV=2" "0.000" "False" "42.782" "29" "12" "21" "12" "457" "51.2" "5.90" "78.02" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00254, Pf00515" "2289" "ENSG00000096060" "FKBP5" "F5H7R1; hsa:2289; Q13451; Q59EB8; Q5TGM6" "Androgen receptor network in prostate cancer; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; MECP2 and associated Rett syndrome" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; ESR-mediated signaling; MECP2 regulates neuronal receptors and channels" "7" "0" "0.937" "0.973" "0.940" "0.962" "0.964" "0.975" "0.966" "0.973" "0.988" "3905.4" "3660.3" "3798.1" "3671.7" "3758.4" "3765.7" "3807.5" "3774.6" "3800.3" "3859.6" "" "" "" "" "" "" "" "" "" "" "3659.4" "3028.8" "3526.1" "2838.4" "3203.6" "3597.8" "3479.0" "3351.5" "3800.3" "3716.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6939588679820243468" "False" "High" "IsMasterProtein" "P23193" "Transcription elongation factor A protein 1 OS=Homo sapiens OX=9606 GN=TCEA1 PE=1 SV=2" "0.000" "False" "42.766" "45" "12" "21" "10" "301" "33.9" "8.38" "59.82" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf07500, Pf08711" "6917" "ENSG00000187735" "TCEA1" "A6NF25; A8K339; hsa:6917; P23193; Q15563; Q6FG87" "" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "15" "1" "1.080" "1.007" "1.020" "1.064" "1.080" "1.055" "1.087" "0.995" "1.025" "2220.2" "2396.9" "2235.8" "2265.5" "2362.1" "2397.3" "2342.1" "2413.0" "2209.0" "2274.8" "" "" "" "" "" "" "" "" "" "" "2080.3" "1983.4" "2075.7" "1751.3" "2013.4" "2290.4" "2140.1" "2142.5" "2209.0" "2190.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7462391840116260305" "False" "High" "IsMasterProtein" "Q05086" "Ubiquitin-protein ligase E3A OS=Homo sapiens OX=9606 GN=UBE3A PE=1 SV=4" "0.000" "False" "42.753" "16" "14" "15" "14" "875" "100.6" "5.22" "47.50" "14" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00632, Pf16558" "7337" "ENSG00000114062" "UBE3A" "A8K8Z9; hsa:7337; P78355; Q05086; Q93066; Q9UEP4; Q9UEP5; Q9UEP6; Q9UEP7; Q9UEP8; Q9UEP9" "Androgen receptor signaling pathway; MECP2 and associated Rett syndrome; Prader-Willi and Angelman syndrome; Synaptic signaling pathways associated with autism spectrum disorder" "Antigen processing: Ubiquitination & Proteasome degradation" "5" "0" "0.966" "0.990" "0.997" "0.999" "0.943" "0.983" "0.983" "0.964" "0.960" "2073.5" "2004.0" "2052.6" "2067.9" "2070.5" "1954.7" "2037.3" "2038.3" "1997.9" "1990.5" "" "" "" "" "" "" "" "" "" "" "1942.8" "1658.3" "1905.6" "1598.6" "1764.8" "1867.6" "1861.6" "1809.8" "1997.9" "1916.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2943690132932996841" "False" "High" "IsMasterProtein" "P10412" "Histone H1.4 OS=Homo sapiens OX=9606 GN=H1-4 PE=1 SV=2" "0.000" "False" "42.751" "41" "11" "23" "3" "219" "21.9" "11.03" "81.09" "11" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3008" "ENSG00000168298" "H1-4" "hsa:3008; P10412; Q4VB25" "Pathways affected in adenoid cystic carcinoma" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "3" "0" "0.925" "0.957" "0.894" "0.965" "0.866" "1.105" "0.872" "0.845" "0.925" "403.5" "373.4" "386.3" "360.7" "389.4" "349.5" "445.7" "352.1" "341.0" "373.1" "" "" "" "" "" "" "" "" "" "" "378.1" "309.0" "358.6" "278.8" "331.9" "333.9" "407.3" "312.6" "341.0" "359.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5656635003875974689" "False" "High" "IsMasterProtein" "Q13111" "Chromatin assembly factor 1 subunit A OS=Homo sapiens OX=9606 GN=CHAF1A PE=1 SV=3" "0.000" "False" "42.679" "16" "14" "19" "14" "956" "106.8" "5.94" "61.67" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf11600, Pf12253, Pf15539, Pf15557" "10036" "ENSG00000167670" "CHAF1A" "hsa:10036; Q13111; Q6NXG5; Q7Z7K3; Q9UJY8" "Nanoparticle triggered autophagic cell death" "" "1" "0" "1.030" "1.036" "1.034" "1.042" "0.970" "1.002" "0.959" "0.919" "0.995" "1819.9" "1875.0" "1885.6" "1881.9" "1896.0" "1766.2" "1823.0" "1745.8" "1673.2" "1810.5" "" "" "" "" "" "" "" "" "" "" "1705.2" "1551.5" "1750.6" "1454.8" "1616.1" "1687.4" "1665.7" "1550.1" "1673.2" "1743.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8790717896449630852" "False" "High" "IsMasterProtein" "Q9UPT8" "Zinc finger CCCH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=ZC3H4 PE=1 SV=3" "0.000" "False" "42.510" "14" "13" "17" "12" "1303" "140.2" "6.27" "59.34" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608, Pf18044" "23211" "ENSG00000130749" "ZC3H4" "hsa:23211; Q9UPT8; Q9Y420" "" "" "0" "0" "1.131" "1.184" "1.113" "1.120" "1.011" "1.359" "1.407" "1.333" "1.192" "1401.5" "1585.4" "1659.4" "1560.2" "1570.2" "1417.5" "1905.0" "1971.3" "1868.7" "1671.1" "" "" "" "" "" "" "" "" "" "" "1313.2" "1311.9" "1540.5" "1206.1" "1338.4" "1354.3" "1740.7" "1750.3" "1868.7" "1609.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3931502688338012469" "False" "High" "IsMasterProtein" "P35249" "Replication factor C subunit 4 OS=Homo sapiens OX=9606 GN=RFC4 PE=1 SV=2" "0.000" "False" "42.504" "40" "13" "20" "13" "363" "39.7" "8.02" "64.88" "13" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5984" "ENSG00000163918" "RFC4" "B4DM41; D3DNV2; hsa:5984; P35249; Q6FHX7" "Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Activation of ATR in response to replication stress; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "28" "0" "1.031" "0.966" "1.045" "1.003" "1.005" "0.969" "0.957" "0.994" "0.963" "2683.0" "2765.0" "2592.0" "2802.7" "2691.9" "2695.5" "2599.4" "2567.4" "2666.8" "2584.7" "" "" "" "" "" "" "" "" "" "" "2513.9" "2288.0" "2406.3" "2166.6" "2294.5" "2575.3" "2375.2" "2279.6" "2666.8" "2488.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5656717572997732758" "False" "High" "IsMasterProtein" "P30566" "Adenylosuccinate lyase OS=Homo sapiens OX=9606 GN=ADSL PE=1 SV=2" "0.000" "False" "42.474" "26" "13" "21" "13" "484" "54.9" "7.11" "66.97" "13" "other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00206, Pf10397" "158" "ENSG00000239900" "ADSL" "B0QY76; hsa:158; O75495; P30566; Q5TI34" "" "Purine ribonucleoside monophosphate biosynthesis" "1" "0" "0.972" "0.997" "0.972" "0.986" "0.977" "0.946" "0.971" "0.952" "0.961" "2655.0" "2581.7" "2645.9" "2581.3" "2617.9" "2593.0" "2510.5" "2577.3" "2527.2" "2551.4" "" "" "" "" "" "" "" "" "" "" "2487.8" "2136.3" "2456.4" "1995.5" "2231.4" "2477.4" "2293.9" "2288.4" "2527.2" "2456.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9177231757861531522" "False" "High" "IsMasterProtein" "P25685" "DnaJ homolog subfamily B member 1 OS=Homo sapiens OX=9606 GN=DNAJB1 PE=1 SV=4" "0.000" "False" "42.441" "38" "14" "21" "14" "340" "38.0" "8.63" "61.04" "14" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00226, Pf01556" "3337" "ENSG00000132002" "DNAJB1" "B4DX52; hsa:3337; P25685" "Nuclear receptors meta-pathway; NRF2 pathway" "MAPK6/MAPK4 signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Regulation of HSF1-mediated heat shock response; Attenuation phase" "7" "0" "0.979" "1.011" "0.977" "1.021" "1.036" "0.992" "0.978" "0.994" "0.978" "3067.7" "3002.8" "3101.6" "2997.4" "3132.7" "3178.6" "3044.7" "3001.5" "3050.5" "2998.7" "" "" "" "" "" "" "" "" "" "" "2874.4" "2484.8" "2879.4" "2317.2" "2670.2" "3036.8" "2782.0" "2665.0" "3050.5" "2887.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2946380844768102927" "False" "High" "IsMasterProtein" "Q96I24" "Far upstream element-binding protein 3 OS=Homo sapiens OX=9606 GN=FUBP3 PE=1 SV=2" "0.000" "False" "42.406" "24" "15" "24" "11" "572" "61.6" "8.38" "72.17" "15" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf00013" "8939" "ENSG00000107164" "FUBP3" "A3KFK8; A3KFL0; hsa:8939; Q92946; Q96I24; Q9BVB6" "" "" "0" "0" "1.008" "1.008" "0.978" "0.975" "0.978" "0.953" "0.965" "0.974" "0.978" "1888.1" "1902.8" "1902.6" "1846.1" "1841.3" "1847.1" "1798.9" "1822.2" "1839.5" "1847.4" "" "" "" "" "" "" "" "" "" "" "1769.1" "1574.5" "1766.3" "1427.1" "1569.5" "1764.7" "1643.7" "1617.9" "1839.5" "1778.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7286073100971465543" "False" "High" "IsMasterProtein" "O95466" "Formin-like protein 1 OS=Homo sapiens OX=9606 GN=FMNL1 PE=1 SV=3" "0.000" "False" "42.319" "14" "15" "16" "15" "1100" "121.8" "5.72" "45.76" "15" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "cytoskeletal activity;other molecular function" "Pf02181, Pf06367, Pf06371" "752" "ENSG00000184922" "FMNL1" "D2DGW2; hsa:752; O95466; Q6DKG5; Q6IBP3; Q86UH1; Q8N671; Q8TDH1; Q96H10" "" "RHO GTPases Activate Formins; CDC42 GTPase cycle; RAC1 GTPase cycle" "3" "0" "0.961" "0.967" "0.972" "0.939" "0.980" "0.962" "0.916" "0.926" "0.967" "1167.1" "1121.4" "1128.0" "1134.6" "1096.1" "1143.4" "1123.2" "1069.1" "1081.0" "1129.1" "" "" "" "" "" "" "" "" "" "" "1093.5" "927.9" "1047.2" "877.1" "934.3" "1092.4" "1026.3" "949.2" "1081.0" "1087.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1392727006884078861" "False" "High" "IsMasterProtein" "P51692" "Signal transducer and activator of transcription 5B OS=Homo sapiens OX=9606 GN=STAT5B PE=1 SV=2" "0.000" "False" "42.309" "15" "12" "19" "2" "787" "89.8" "6.05" "60.15" "12" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf21354" "6777" "ENSG00000173757" "STAT5B" "hsa:6777; P51692; Q8WWS8" "IL-5 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Chemokine signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; White fat cell differentiation; Non-small cell lung cancer; EGF/EGFR signaling pathway; Measles virus infection; Hepatitis B infection; Endochondral ossification; Endochondral ossification with skeletal dysplasias; IL-2 signaling pathway; 3q29 copy number variation syndrome; FOXP3 in COVID-19; Familial partial lipodystrophy; Acute myeloid leukemia; JAK-STAT signaling in the regulation of beta cells; EPO receptor signaling; ErbB signaling pathway" "Interleukin-3, Interleukin-5 and GM-CSF signaling; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Growth hormone receptor signaling; Signaling by Leptin; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; Prolactin receptor signaling; Interleukin-20 family signaling; Erythropoietin activates STAT5; Signaling by FLT3 fusion proteins; Interleukin-2 signaling; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling; STAT5 Activation" "51" "0" "1.119" "1.191" "1.317" "1.168" "1.074" "1.203" "1.227" "0.983" "1.059" "39.5" "44.2" "47.0" "52.0" "46.1" "42.4" "47.5" "48.4" "38.8" "41.8" "" "" "" "" "" "" "" "" "" "" "37.0" "36.5" "43.6" "40.2" "39.3" "40.5" "43.4" "43.0" "38.8" "40.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6930052097087835026" "False" "High" "IsMasterProtein" "Q15003" "Condensin complex subunit 2 OS=Homo sapiens OX=9606 GN=NCAPH PE=1 SV=3" "0.000" "False" "42.292" "20" "13" "19" "13" "741" "82.5" "5.06" "64.37" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05786" "23397" "ENSG00000121152" "NCAPH" "B4E189; hsa:23397; Q15003; Q8TB87" "2q11.2 copy number variation syndrome" "Condensation of Prometaphase Chromosomes" "2" "0" "0.957" "0.968" "0.957" "0.970" "0.961" "0.886" "0.891" "0.848" "0.935" "2131.1" "2038.4" "2063.3" "2039.6" "2066.3" "2047.2" "1888.1" "1899.0" "1807.8" "1993.6" "" "" "" "" "" "" "" "" "" "" "1996.8" "1686.8" "1915.5" "1576.7" "1761.3" "1955.9" "1725.2" "1686.1" "1807.8" "1919.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5974744531153524067" "False" "High" "IsMasterProtein" "Q01581" "Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=HMGCS1 PE=1 SV=2" "0.000" "False" "42.247" "23" "11" "19" "11" "520" "57.3" "5.41" "61.77" "11" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01154, Pf08540" "3157" "ENSG00000112972" "HMGCS1" "B2RDL8; hsa:3157; Q01581" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "13" "0" "0.986" "0.986" "1.010" "0.941" "0.969" "0.940" "0.977" "0.948" "0.934" "2197.7" "2165.9" "2166.4" "2219.2" "2068.6" "2129.5" "2066.7" "2146.3" "2083.9" "2053.2" "" "" "" "" "" "" "" "" "" "" "2059.3" "1792.2" "2011.3" "1715.6" "1763.2" "2034.5" "1888.4" "1905.7" "2083.9" "1976.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6209477172492729631" "False" "High" "IsMasterProtein" "Q9UPN6" "SR-related and CTD-associated factor 8 OS=Homo sapiens OX=9606 GN=SCAF8 PE=1 SV=1" "0.000" "False" "42.243" "11" "14" "18" "13" "1271" "140.4" "8.29" "48.90" "14" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf04818" "22828" "ENSG00000213079" "SCAF8" "B7Z888; hsa:22828; Q5TBU6; Q6NSK3; Q9BQN8; Q9BX43; Q9UPN6" "" "" "0" "1" "1.019" "0.995" "0.970" "1.013" "1.064" "1.013" "0.985" "1.032" "1.041" "1514.2" "1543.1" "1506.1" "1469.1" "1534.2" "1611.2" "1534.6" "1491.1" "1562.2" "1576.0" "" "" "" "" "" "" "" "" "" "" "1418.8" "1276.9" "1398.2" "1135.7" "1307.7" "1539.3" "1402.2" "1323.9" "1562.2" "1517.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9162404171034655345" "False" "High" "IsMasterProtein" "Q9Y223" "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase OS=Homo sapiens OX=9606 GN=GNE PE=1 SV=1" "0.000" "False" "42.220" "17" "11" "16" "11" "722" "79.2" "6.80" "49.25" "11" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf00480, Pf02350" "10020" "ENSG00000159921" "GNE" "A6PZH2; A6PZH3; A7UNU7; B2R6E1; B7Z372; B7Z428; D3DRP7; F5H499; H0YFA7; hsa:10020; Q0VA94; Q9Y223" "Sialylation" "Sialic acid metabolism; Defective GNE causes sialuria, NK and IBM2" "3" "0" "1.013" "1.053" "1.034" "1.011" "0.961" "1.006" "0.968" "0.995" "0.987" "1022.2" "1035.2" "1076.7" "1056.8" "1033.9" "982.7" "1028.5" "989.8" "1016.7" "1008.5" "" "" "" "" "" "" "" "" "" "" "957.8" "856.6" "999.6" "817.0" "881.3" "938.9" "939.8" "878.9" "1016.7" "971.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7657012177295081485" "False" "High" "IsMasterProtein" "O43684" "Mitotic checkpoint protein BUB3 OS=Homo sapiens OX=9606 GN=BUB3 PE=1 SV=1" "0.000" "False" "42.063" "30" "9" "22" "9" "328" "37.1" "6.84" "79.18" "9" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "9184" "ENSG00000154473" "BUB3" "A6NJ42; B2R6E7; D3DRE9; hsa:9184; O43684; O43685" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "12" "0" "1.020" "1.048" "1.089" "0.993" "1.033" "1.017" "1.048" "1.117" "1.009" "2387.2" "2434.0" "2500.9" "2599.4" "2370.4" "2465.8" "2426.8" "2500.6" "2666.8" "2409.3" "" "" "" "" "" "" "" "" "" "" "2236.8" "2014.1" "2321.8" "2009.5" "2020.4" "2355.8" "2217.4" "2220.3" "2666.8" "2319.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "29627463948576905" "False" "High" "IsMasterProtein" "Q9NUQ8" "ATP-binding cassette sub-family F member 3 OS=Homo sapiens OX=9606 GN=ABCF3 PE=1 SV=2" "0.000" "False" "41.988" "19" "13" "16" "13" "709" "79.7" "6.34" "50.83" "13" "stress response" "" "other molecular function" "Pf00005, Pf12848" "55324" "ENSG00000161204" "ABCF3" "A8K241; hsa:55324; Q86UA2; Q8NAN1; Q96GS8; Q9H7A8; Q9NUQ8" "" "" "0" "0" "1.011" "0.978" "1.092" "1.031" "1.015" "1.002" "0.986" "0.986" "1.009" "1080.4" "1091.9" "1056.8" "1179.5" "1114.1" "1096.7" "1083.1" "1065.3" "1065.1" "1090.5" "" "" "" "" "" "" "" "" "" "" "1012.4" "903.5" "981.1" "911.8" "949.6" "1047.8" "989.7" "945.9" "1065.1" "1050.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-65550439794871329" "False" "High" "IsMasterProtein" "Q9BXS5" "AP-1 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP1M1 PE=1 SV=3" "0.000" "False" "41.953" "39" "15" "17" "15" "423" "48.6" "7.30" "53.09" "15" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00928, Pf01217" "8907" "ENSG00000072958" "AP1M1" "hsa:8907; Q4TTY5; Q9BXS5" "" "MHC class II antigen presentation; Neutrophil degranulation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "5" "0" "0.968" "1.039" "1.021" "1.001" "1.014" "0.998" "1.005" "0.999" "0.999" "3047.9" "2951.5" "3166.9" "3111.5" "3049.9" "3090.0" "3042.6" "3064.5" "3044.8" "3043.6" "" "" "" "" "" "" "" "" "" "" "2855.9" "2442.4" "2940.1" "2405.4" "2599.6" "2952.2" "2780.1" "2721.0" "3044.8" "2930.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5518628090009250384" "False" "High" "IsMasterProtein" "Q3V6T2" "Girdin OS=Homo sapiens OX=9606 GN=CCDC88A PE=1 SV=2" "0.000" "False" "41.897" "8" "17" "20" "17" "1871" "215.9" "6.21" "46.29" "17" "cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf19047" "55704" "ENSG00000115355" "CCDC88A" "A1IGE7; B7ZM78; C9JG83; hsa:55704; Q3V6T2; Q53SF1; Q581G3; Q5HYD0; Q7Z339; Q7Z3C5" "Mesodermal commitment pathway" "RND3 GTPase cycle; RND1 GTPase cycle" "3" "0" "1.004" "1.020" "1.021" "1.032" "0.993" "0.948" "0.962" "0.946" "1.027" "1675.7" "1682.8" "1708.9" "1710.9" "1728.7" "1663.1" "1589.0" "1612.2" "1585.9" "1720.6" "" "" "" "" "" "" "" "" "" "" "1570.1" "1392.5" "1586.5" "1322.6" "1473.5" "1588.9" "1451.9" "1431.5" "1585.9" "1656.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8717421015690566095" "False" "High" "IsMasterProtein" "Q9NQR4" "Omega-amidase NIT2 OS=Homo sapiens OX=9606 GN=NIT2 PE=1 SV=1" "0.000" "False" "41.866" "49" "13" "23" "13" "276" "30.6" "7.21" "75.27" "13" "other metabolic processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00795" "56954" "ENSG00000114021" "NIT2" "B2R9A3; D3DN47; hsa:56954; Q8WUF0; Q9NQR4" "" "Neutrophil degranulation" "1" "0" "0.976" "0.966" "0.951" "0.899" "0.946" "0.867" "0.962" "0.964" "0.962" "2758.5" "2691.9" "2664.5" "2622.2" "2479.5" "2609.2" "2392.2" "2654.2" "2659.8" "2652.4" "" "" "" "" "" "" "" "" "" "" "2584.7" "2227.5" "2473.7" "2027.1" "2113.5" "2492.9" "2185.8" "2356.7" "2659.8" "2553.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1917909410339364485" "False" "High" "IsMasterProtein" "Q96QC0" "Serine/threonine-protein phosphatase 1 regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PPP1R10 PE=1 SV=1" "0.000" "False" "41.844" "14" "14" "16" "14" "940" "99.0" "9.17" "50.39" "14" "transport;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00642, Pf08711" "5514" "ENSG00000204569; ENSG00000206489; ENSG00000227804; ENSG00000230995; ENSG00000231737; ENSG00000235291; ENSG00000238104" "PPP1R10" "hsa:5514; O00405; Q96QC0" "" "" "0" "0" "0.986" "1.012" "0.985" "1.030" "1.085" "1.043" "1.083" "1.074" "1.046" "2856.3" "2816.1" "2889.8" "2813.8" "2943.0" "3099.3" "2978.2" "3091.9" "3067.5" "2986.5" "" "" "" "" "" "" "" "" "" "" "2676.3" "2330.3" "2682.8" "2175.2" "2508.5" "2961.1" "2721.3" "2745.3" "3067.5" "2875.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7607180034342260294" "False" "High" "IsMasterProtein" "Q6P179" "Endoplasmic reticulum aminopeptidase 2 OS=Homo sapiens OX=9606 GN=ERAP2 PE=1 SV=2" "0.000" "False" "41.798" "15" "15" "23" "15" "960" "110.4" "6.71" "60.16" "15" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "64167" "ENSG00000164308" "ERAP2" "hsa:64167; Q6P179; Q7Z5K1; Q8TD32; Q8WVJ4; Q9HBX2" "" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "1" "0" "1.047" "0.988" "1.049" "1.027" "1.004" "1.011" "0.955" "1.056" "0.995" "2035.9" "2131.9" "2011.2" "2136.5" "2091.7" "2043.6" "2057.6" "1943.3" "2149.4" "2025.7" "" "" "" "" "" "" "" "" "" "" "1907.6" "1764.1" "1867.1" "1651.6" "1782.9" "1952.5" "1880.1" "1725.4" "2149.4" "1950.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8117558468974038429" "False" "High" "IsMasterProtein" "Q96Q11" "CCA tRNA nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=TRNT1 PE=1 SV=2" "0.000" "False" "41.662" "36" "15" "19" "15" "434" "50.1" "8.10" "60.63" "15" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf01743, Pf12627" "51095" "ENSG00000072756" "TRNT1" "A8K2Z6; B7WP13; C9JKA2; hsa:51095; Q8ND57; Q96Q11; Q9BS97; Q9Y362" "" "tRNA processing in the nucleus; tRNA processing in the mitochondrion" "2" "0" "1.042" "1.002" "0.971" "1.011" "0.979" "0.978" "0.989" "1.021" "0.992" "2097.6" "2184.8" "2101.0" "2037.3" "2120.2" "2052.8" "2051.4" "2074.9" "2142.0" "2081.1" "" "" "" "" "" "" "" "" "" "" "1965.4" "1807.9" "1950.5" "1575.0" "1807.2" "1961.2" "1874.4" "1842.3" "2142.0" "2003.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8372926252788997109" "False" "High" "IsMasterProtein" "Q5JTZ9" "Alanine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=AARS2 PE=1 SV=1" "0.000" "False" "41.651" "15" "14" "20" "14" "985" "107.3" "6.27" "69.23" "14" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf01411, Pf07973" "57505" "ENSG00000124608" "AARS2" "A2RRN5; hsa:57505; Q5JTZ9; Q8N198; Q96D02; Q9ULF0" "Primary ovarian insufficiency" "Mitochondrial tRNA aminoacylation" "2" "0" "1.045" "0.959" "1.073" "1.039" "1.035" "0.980" "0.965" "0.943" "0.982" "1967.6" "2056.4" "1887.2" "2111.5" "2044.3" "2036.9" "1928.9" "1898.0" "1855.1" "1932.1" "" "" "" "" "" "" "" "" "" "" "1843.6" "1701.7" "1752.1" "1632.3" "1742.5" "1946.0" "1762.5" "1685.3" "1855.1" "1860.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8097806180956091720" "False" "High" "IsMasterProtein" "Q16576" "Histone-binding protein RBBP7 OS=Homo sapiens OX=9606 GN=RBBP7 PE=1 SV=1" "0.000" "False" "41.634" "35" "12" "23" "7" "425" "47.8" "5.05" "68.44" "12" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "5931" "ENSG00000102054" "RBBP7" "hsa:5931; Q16576; Q5JP00" "Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Effect of progerin on genes involved in progeria" "Transcriptional Regulation by E2F6; Activation of anterior HOX genes in hindbrain development during early embryogenesis; HCMV Early Events; Neddylation; Potential therapeutics for SARS; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; HDACs deacetylate histones; RMTs methylate histone arginines; PKMTs methylate histone lysines; HATs acetylate histones; RNA Polymerase I Transcription Initiation; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "20" "4" "0.961" "1.014" "0.915" "0.963" "0.970" "0.942" "0.999" "1.011" "0.964" "2508.6" "2409.8" "2542.9" "2296.5" "2414.9" "2432.7" "2362.7" "2507.1" "2535.6" "2418.8" "" "" "" "" "" "" "" "" "" "" "2350.5" "1994.0" "2360.8" "1775.3" "2058.4" "2324.2" "2158.9" "2226.1" "2535.6" "2329.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8527092773428768711" "False" "High" "IsMasterProtein" "Q13561" "Dynactin subunit 2 OS=Homo sapiens OX=9606 GN=DCTN2 PE=1 SV=4" "0.000" "False" "41.619" "37" "13" "15" "13" "401" "44.2" "5.21" "56.30" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04912" "10540" "ENSG00000175203" "DCTN2" "B2RBK5; hsa:10540; Q13561; Q86YN2; Q9BW17" "Vasopressin-regulated water reabsorption" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "12" "0" "1.070" "1.035" "1.090" "1.065" "1.090" "0.998" "1.017" "1.042" "1.051" "1809.0" "1935.8" "1872.6" "1972.6" "1926.2" "1971.3" "1805.3" "1839.8" "1884.5" "1902.1" "" "" "" "" "" "" "" "" "" "" "1695.0" "1601.8" "1738.4" "1524.9" "1641.9" "1883.4" "1649.6" "1633.6" "1884.5" "1831.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6534553132144552728" "False" "High" "IsMasterProtein" "Q09028" "Histone-binding protein RBBP4 OS=Homo sapiens OX=9606 GN=RBBP4 PE=1 SV=3" "0.000" "False" "41.557" "28" "10" "20" "5" "425" "47.6" "4.89" "68.22" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "5928" "ENSG00000162521" "RBBP4" "B2R6G9; B4DRH0; D3DPQ3; hsa:5928; P31149; Q09028; Q53H02; Q96BV9" "Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; Effect of progerin on genes involved in progeria; Pleural mesothelioma; DYRK1A involvement regarding cell proliferation in brain development" "RNA Polymerase I Transcription Initiation; Potential therapeutics for SARS; HCMV Early Events; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; G1/S-Specific Transcription; Regulation of TP53 Activity through Acetylation; Polo-like kinase mediated events; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "28" "0" "1.059" "1.056" "0.960" "0.986" "0.989" "0.976" "1.046" "1.072" "1.030" "909.5" "963.0" "960.3" "873.4" "896.5" "899.6" "887.9" "951.2" "974.7" "936.6" "" "" "" "" "" "" "" "" "" "" "852.2" "796.9" "891.5" "675.2" "764.2" "859.5" "811.3" "844.6" "974.7" "901.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5564362200897381814" "False" "High" "IsMasterProtein" "Q9P2N5" "RNA-binding protein 27 OS=Homo sapiens OX=9606 GN=RBM27 PE=1 SV=2" "0.000" "False" "41.504" "11" "12" "17" "11" "1060" "118.6" "9.19" "56.71" "12" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00076, Pf00642, Pf01480" "54439" "ENSG00000091009" "RBM27" "hsa:54439; Q8IYW9; Q9P2N5" "" "" "0" "0" "1.022" "1.063" "1.020" "1.060" "1.060" "1.138" "1.169" "1.179" "1.113" "1167.6" "1193.7" "1241.1" "1190.8" "1238.2" "1237.7" "1328.2" "1364.7" "1376.6" "1299.1" "" "" "" "" "" "" "" "" "" "" "1094.0" "987.8" "1152.2" "920.5" "1055.4" "1182.5" "1213.6" "1211.7" "1376.6" "1250.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3787459776374465912" "False" "High" "IsMasterProtein" "Q9Y5L0" "Transportin-3 OS=Homo sapiens OX=9606 GN=TNPO3 PE=1 SV=3" "0.000" "False" "41.484" "15" "12" "16" "12" "923" "104.1" "5.57" "49.72" "12" "transport" "other membranes;nucleus;other cell component" "other molecular function" "Pf08389" "23534" "ENSG00000064419" "TNPO3" "A4D1K9; C9IZM0; hsa:23534; Q6NUM1; Q96G71; Q96GU9; Q9Y3R2; Q9Y5L0" "" "" "0" "0" "0.992" "1.029" "1.043" "1.017" "1.012" "1.064" "1.025" "1.005" "0.974" "1691.0" "1676.9" "1739.7" "1763.4" "1719.8" "1710.7" "1799.9" "1733.8" "1698.8" "1646.7" "" "" "" "" "" "" "" "" "" "" "1584.5" "1387.7" "1615.1" "1363.2" "1465.9" "1634.4" "1644.6" "1539.4" "1698.8" "1585.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4375122853346024923" "False" "High" "IsMasterProtein" "Q9C0E2" "Exportin-4 OS=Homo sapiens OX=9606 GN=XPO4 PE=1 SV=2" "0.000" "False" "41.479" "12" "14" "18" "13" "1151" "130.1" "5.05" "53.03" "14" "transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08767" "64328" "ENSG00000132953" "XPO4" "hsa:64328; Q5VUZ5; Q8N3V6; Q9C0E2; Q9H934" "eIF5A regulation in response to inhibition of the nuclear export system" "" "1" "0" "0.889" "1.004" "1.031" "1.009" "1.026" "1.038" "0.982" "1.007" "0.987" "1329.1" "1181.1" "1334.0" "1370.9" "1340.8" "1363.4" "1379.5" "1305.1" "1338.5" "1311.7" "" "" "" "" "" "" "" "" "" "" "1245.4" "977.4" "1238.5" "1059.8" "1142.9" "1302.6" "1260.5" "1158.8" "1338.5" "1263.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5554010069989842743" "False" "High" "IsMasterProtein" "Q9BZZ5" "Apoptosis inhibitor 5 OS=Homo sapiens OX=9606 GN=API5 PE=1 SV=3" "0.000" "False" "41.478" "22" "11" "27" "11" "524" "59.0" "7.34" "74.58" "11" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf05918" "8539" "ENSG00000166181" "API5" "B4DGR0; B4DRJ2; B4E283; D3DR21; G3V1C3; hsa:8539; O15441; Q9BZZ5; Q9Y4J7" "" "" "0" "0" "1.018" "1.048" "1.043" "1.044" "1.055" "1.070" "1.085" "1.071" "1.040" "1383.2" "1408.1" "1450.3" "1443.3" "1443.7" "1458.7" "1480.2" "1501.3" "1481.2" "1438.6" "" "" "" "" "" "" "" "" "" "" "1296.1" "1165.2" "1346.4" "1115.7" "1230.6" "1393.7" "1352.5" "1333.0" "1481.2" "1385.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1322674044200343444" "False" "High" "IsMasterProtein" "Q12789" "General transcription factor 3C polypeptide 1 OS=Homo sapiens OX=9606 GN=GTF3C1 PE=1 SV=4" "0.000" "False" "41.432" "7" "17" "21" "17" "2109" "238.7" "7.30" "59.99" "17" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04182" "2975" "ENSG00000077235" "GTF3C1" "B2RP21; hsa:2975; Q12789; Q12838; Q6DKN9; Q9Y4W9" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "3" "0" "0.994" "1.026" "0.972" "1.016" "0.999" "0.960" "0.884" "0.903" "0.990" "2181.0" "2167.3" "2237.9" "2119.9" "2215.8" "2179.8" "2093.6" "1926.9" "1969.5" "2160.1" "" "" "" "" "" "" "" "" "" "" "2043.6" "1793.4" "2077.6" "1638.8" "1888.7" "2082.6" "1913.0" "1710.9" "1969.5" "2079.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3599424746602695209" "False" "High" "IsMasterProtein" "Q9ULE6" "Paladin OS=Homo sapiens OX=9606 GN=PALD1 PE=1 SV=3" "0.000" "False" "41.408" "13" "12" "14" "12" "856" "96.7" "6.54" "46.71" "12" "" "cytosol;other cell component" "other molecular function" "Pf14566" "27143" "ENSG00000107719" "PALD1" "B2RMS1; B9EGC6; hsa:27143; Q5JTK7; Q5JTK8; Q9ULE6" "" "" "0" "0" "1.017" "1.022" "1.047" "1.029" "1.036" "0.984" "0.993" "1.000" "1.002" "1660.2" "1687.6" "1696.2" "1737.4" "1707.9" "1719.2" "1633.1" "1647.8" "1660.2" "1662.8" "" "" "" "" "" "" "" "" "" "" "1555.6" "1396.5" "1574.7" "1343.1" "1455.8" "1642.5" "1492.2" "1463.1" "1660.2" "1601.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4934809763916306973" "False" "High" "IsMasterProtein" "Q6ZS81" "WD repeat- and FYVE domain-containing protein 4 OS=Homo sapiens OX=9606 GN=WDFY4 PE=1 SV=3" "0.000" "False" "41.402" "5" "15" "16" "15" "3184" "353.4" "6.32" "46.31" "15" "other metabolic processes;other biological processes" "ER/Golgi;other cytoplasmic organelle" "" "Pf00400, Pf02138" "57705" "ENSG00000128815" "WDFY4" "B9ZVP2; hsa:57705; Q6ZS81; Q86WZ4; Q8N4A3; Q8TEN7; Q96BE1; Q9H7H8; Q9HCG5" "10q11.21q11.23 copy number variation syndrome" "" "1" "0" "1.033" "1.010" "1.091" "1.009" "0.973" "0.987" "0.896" "0.966" "0.992" "1297.0" "1340.0" "1309.4" "1415.4" "1308.5" "1262.4" "1279.7" "1162.2" "1253.0" "1286.2" "" "" "" "" "" "" "" "" "" "" "1215.3" "1108.8" "1215.6" "1094.2" "1115.4" "1206.1" "1169.3" "1031.9" "1253.0" "1238.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4797790429512717329" "False" "High" "IsMasterProtein" "O75874" "Isocitrate dehydrogenase [NADP] cytoplasmic OS=Homo sapiens OX=9606 GN=IDH1 PE=1 SV=2" "0.000" "False" "41.352" "32" "13" "22" "12" "414" "46.6" "7.01" "53.35" "13" "other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00180" "3417" "ENSG00000138413" "IDH1" "hsa:3417; O75874; Q567U4; Q6FHQ6; Q7Z3V0; Q93090; Q9NTJ9; Q9UKW8" "Glutathione metabolism; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism" "Peroxisomal protein import; Neutrophil degranulation; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; NADPH regeneration; NFE2L2 regulating TCA cycle genes" "8" "0" "0.993" "0.972" "0.985" "0.986" "0.997" "0.957" "0.983" "0.992" "0.977" "2058.4" "2044.5" "2000.5" "2027.3" "2029.7" "2052.4" "1970.2" "2023.4" "2042.3" "2010.5" "" "" "" "" "" "" "" "" "" "" "1928.7" "1691.8" "1857.2" "1567.2" "1730.1" "1960.9" "1800.3" "1796.6" "2042.3" "1935.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2836831182499166141" "False" "High" "IsMasterProtein" "O00148" "ATP-dependent RNA helicase DDX39A OS=Homo sapiens OX=9606 GN=DDX39A PE=1 SV=2" "0.000" "False" "41.292" "31" "14" "27" "5" "427" "49.1" "5.68" "83.02" "14" "RNA metabolism OR transcription;other metabolic processes;transport" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271" "10212" "ENSG00000123136" "DDX39A" "B1Q2N1; hsa:10212; O00148; Q8N5M0; Q9BVP6; Q9H5W0" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "1.055" "1.103" "1.139" "1.147" "1.097" "1.145" "1.140" "1.117" "1.117" "686.8" "724.4" "757.6" "782.5" "788.1" "753.6" "786.3" "782.9" "767.0" "767.0" "" "" "" "" "" "" "" "" "" "" "643.6" "599.5" "703.3" "604.9" "671.8" "720.0" "718.5" "695.2" "767.0" "738.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3252394429536465777" "False" "High" "IsMasterProtein" "Q32P41" "tRNA (guanine(37)-N1)-methyltransferase OS=Homo sapiens OX=9606 GN=TRMT5 PE=1 SV=3" "0.000" "False" "41.265" "26" "14" "19" "14" "509" "58.2" "8.62" "50.60" "14" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf02475" "57570" "ENSG00000126814" "TRMT5" "B2RN19; hsa:57570; Q32P41; Q9P2F4" "" "Synthesis of wybutosine at G37 of tRNA(Phe)" "1" "0" "0.918" "1.007" "0.976" "0.986" "0.973" "0.978" "0.979" "1.003" "1.006" "2647.2" "2431.0" "2666.3" "2584.9" "2610.9" "2576.3" "2588.4" "2591.3" "2655.8" "2664.1" "" "" "" "" "" "" "" "" "" "" "2480.4" "2011.6" "2475.3" "1998.3" "2225.5" "2461.4" "2365.1" "2300.8" "2655.8" "2565.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7688952667704275831" "False" "High" "IsMasterProtein" "O14818" "Proteasome subunit alpha type-7 OS=Homo sapiens OX=9606 GN=PSMA7 PE=1 SV=1" "0.000" "False" "41.232" "39" "10" "18" "10" "248" "27.9" "8.46" "58.52" "10" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf10584" "5688" "ENSG00000101182" "PSMA7" "B2R515; hsa:5688; O14818; Q5JXJ2; Q9BR53; Q9H4K5; Q9UEU8" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.953" "0.977" "0.901" "0.933" "0.990" "0.929" "0.922" "0.994" "0.924" "1829.6" "1744.0" "1787.4" "1649.1" "1707.5" "1812.2" "1698.9" "1687.1" "1818.6" "1691.1" "" "" "" "" "" "" "" "" "" "" "1714.4" "1443.2" "1659.3" "1274.8" "1455.5" "1731.3" "1552.3" "1498.0" "1818.6" "1628.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9080862626962095597" "False" "High" "IsMasterProtein" "O75312" "Zinc finger protein ZPR1 OS=Homo sapiens OX=9606 GN=ZPR1 PE=1 SV=1" "0.000" "False" "41.091" "31" "13" "17" "13" "459" "50.9" "4.73" "61.34" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf03367" "8882" "ENSG00000109917" "ZPR1" "hsa:8882; O75312; Q2TAA0" "" "" "0" "0" "1.088" "0.951" "1.001" "1.029" "1.022" "1.015" "1.075" "1.054" "1.005" "2410.4" "2621.9" "2291.3" "2412.4" "2480.2" "2463.0" "2445.5" "2591.8" "2541.1" "2422.2" "" "" "" "" "" "" "" "" "" "" "2258.6" "2169.6" "2127.2" "1864.9" "2114.1" "2353.2" "2234.6" "2301.3" "2541.1" "2332.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7171410217774938332" "False" "High" "IsMasterProtein" "Q96T51" "RUN and FYVE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RUFY1 PE=1 SV=2" "0.000" "False" "41.040" "22" "16" "22" "16" "708" "79.8" "5.74" "65.07" "16" "transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf02759" "80230" "ENSG00000176783; ENSG00000284260" "RUFY1" "hsa:80230; Q59FF3; Q71S93; Q96T51; Q9H6I3" "" "Synthesis of PIPs at the plasma membrane" "1" "0" "1.011" "1.001" "0.984" "1.028" "1.057" "0.976" "1.022" "0.971" "1.028" "2301.3" "2327.1" "2302.9" "2265.2" "2366.9" "2432.6" "2245.4" "2351.1" "2234.7" "2364.9" "" "" "" "" "" "" "" "" "" "" "2156.3" "1925.7" "2137.9" "1751.1" "2017.5" "2324.1" "2051.7" "2087.5" "2234.7" "2277.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5432753500567823498" "False" "High" "IsMasterProtein" "O75390" "Citrate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=CS PE=1 SV=2" "0.000" "False" "41.004" "25" "11" "22" "11" "466" "51.7" "8.32" "56.69" "11" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00285" "1431" "ENSG00000062485" "CS" "hsa:1431; O75390; Q71UT9; Q7KZH0; Q96FZ8; Q9BWN8" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein import; Mitochondrial protein degradation" "7" "0" "0.949" "0.997" "0.924" "0.990" "1.020" "0.902" "0.985" "0.997" "0.939" "1497.1" "1420.3" "1493.2" "1382.8" "1482.8" "1526.4" "1350.7" "1475.3" "1492.5" "1406.2" "" "" "" "" "" "" "" "" "" "" "1402.8" "1175.2" "1386.3" "1069.0" "1263.9" "1458.3" "1234.2" "1309.9" "1492.5" "1354.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2769761607326504072" "False" "High" "IsMasterProtein" "Q9Y3P9" "Rab GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RABGAP1 PE=1 SV=3" "0.000" "False" "40.893" "14" "14" "15" "14" "1069" "121.7" "5.25" "44.59" "14" "cell cycle OR cell proliferation;other biological processes" "cytosol;cytoskeleton" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00566, Pf00640, Pf12473" "23637" "ENSG00000011454" "RABGAP1" "B9A6L2; hsa:23637; Q05CW2; Q6ZMY1; Q9HA28; Q9P0E2; Q9UG67; Q9Y3P9" "" "TBC/RABGAPs" "1" "0" "0.986" "0.972" "0.977" "1.020" "1.024" "0.962" "0.985" "0.980" "1.032" "1874.9" "1847.8" "1822.1" "1831.4" "1913.1" "1920.5" "1804.6" "1846.6" "1836.7" "1934.0" "" "" "" "" "" "" "" "" "" "" "1756.8" "1529.0" "1691.6" "1415.8" "1630.7" "1834.8" "1648.9" "1639.6" "1836.7" "1862.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8479889696518381262" "False" "High" "IsMasterProtein" "P37802" "Transgelin-2 OS=Homo sapiens OX=9606 GN=TAGLN2 PE=1 SV=3" "0.000" "False" "40.791" "50" "9" "48" "9" "199" "22.4" "8.25" "133.93" "9" "cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton" "cytoskeletal activity" "Pf00307, Pf00402" "8407" "ENSG00000158710" "TAGLN2" "E9KL39; hsa:8407; P37802; Q5JRQ6; Q5JRQ7; Q6FGI1; Q9BUH5; Q9H4P0" "" "Platelet degranulation" "1" "0" "1.094" "0.981" "0.999" "0.981" "0.975" "0.947" "0.956" "1.081" "0.997" "4142.9" "4530.4" "4063.6" "4140.0" "4064.6" "4039.5" "3921.9" "3960.7" "4476.6" "4131.6" "" "" "" "" "" "" "" "" "" "" "3881.9" "3748.8" "3772.5" "3200.4" "3464.5" "3859.4" "3583.6" "3516.7" "4476.6" "3978.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-684970281821863116" "False" "High" "IsMasterProtein" "Q9BXW9" "Fanconi anemia group D2 protein OS=Homo sapiens OX=9606 GN=FANCD2 PE=1 SV=2" "0.000" "False" "40.733" "10" "14" "19" "14" "1451" "164.0" "5.88" "57.89" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf14631" "2177" "ENSG00000144554" "FANCD2" "hsa:2177; Q2LA86; Q69YP9; Q6PJN7; Q9BQ06; Q9BXW9; Q9H9T9" "miRNA regulation of DNA damage response; 15q13.3 copy number variation syndrome; DNA repair pathways, full network; 15q11q13 copy number variation; DNA damage response" "TP53 Regulates Transcription of DNA Repair Genes; Fanconi Anemia Pathway" "7" "0" "0.986" "0.995" "0.909" "0.988" "1.021" "0.908" "0.970" "0.955" "0.990" "2685.8" "2648.7" "2672.6" "2442.6" "2653.6" "2742.4" "2437.9" "2604.3" "2565.8" "2657.8" "" "" "" "" "" "" "" "" "" "" "2516.6" "2191.8" "2481.1" "1888.3" "2261.9" "2620.1" "2227.6" "2312.4" "2565.8" "2559.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "882715983706929749" "False" "High" "IsMasterProtein" "Q9NZ08" "Endoplasmic reticulum aminopeptidase 1 OS=Homo sapiens OX=9606 GN=ERAP1 PE=1 SV=3" "0.000" "False" "40.691" "12" "12" "18" "12" "941" "107.2" "6.46" "53.37" "12" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01433, Pf11838, Pf17900" "51752" "ENSG00000164307" "ERAP1" "hsa:51752; O60278; Q6UWY6; Q8NEL4; Q8TAD0; Q9NZ08; Q9UHF8; Q9UKY2" "" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "1" "0" "0.940" "1.003" "0.910" "0.980" "1.015" "0.880" "0.951" "0.965" "0.975" "2327.5" "2188.3" "2334.5" "2117.3" "2280.8" "2362.6" "2048.3" "2213.2" "2246.4" "2269.1" "" "" "" "" "" "" "" "" "" "" "2180.9" "1810.8" "2167.3" "1636.8" "1944.1" "2257.3" "1871.6" "1965.1" "2246.4" "2184.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5850236467978773586" "False" "High" "IsMasterProtein" "P40692" "DNA mismatch repair protein Mlh1 OS=Homo sapiens OX=9606 GN=MLH1 PE=1 SV=1" "0.000" "False" "40.691" "20" "15" "17" "15" "756" "84.5" "5.72" "46.70" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01119, Pf13589, Pf16413" "4292" "ENSG00000076242" "MLH1" "B4DI13; B4DQ11; E9PCU2; hsa:4292; P40692" "Ovarian infertility; Chromosomal and microsatellite instability in colorectal cancer ; Male infertility; DNA repair pathways, full network; p53 transcriptional gene network; DNA mismatch repair" "TP53 Regulates Transcription of DNA Repair Genes; Meiotic recombination; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MLH1; Defective Mismatch Repair Associated With PMS2" "12" "0" "0.996" "1.020" "0.976" "0.964" "0.969" "0.919" "0.927" "0.924" "0.977" "1590.4" "1583.4" "1621.8" "1551.9" "1532.7" "1541.8" "1461.4" "1474.1" "1469.0" "1553.8" "" "" "" "" "" "" "" "" "" "" "1490.2" "1310.3" "1505.7" "1199.7" "1306.4" "1473.1" "1335.3" "1308.8" "1469.0" "1496.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3994856410542386969" "False" "High" "IsMasterProtein" "Q9BW92" "Threonine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=TARS2 PE=1 SV=1" "0.000" "False" "40.652" "19" "14" "17" "14" "718" "81.0" "7.30" "52.19" "14" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00587, Pf02824, Pf03129, Pf07973" "80222" "ENSG00000143374" "TARS2" "hsa:80222; Q53GW7; Q96I50; Q9BW92; Q9H9V2" "" "Mitochondrial tRNA aminoacylation" "1" "0" "0.974" "0.973" "0.955" "0.992" "0.969" "0.936" "0.944" "0.959" "0.975" "1954.7" "1904.8" "1901.4" "1866.9" "1938.1" "1893.7" "1830.4" "1844.6" "1874.2" "1905.5" "" "" "" "" "" "" "" "" "" "" "1831.6" "1576.2" "1765.2" "1443.2" "1652.0" "1809.3" "1672.5" "1637.8" "1874.2" "1834.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1343514979661683430" "False" "High" "IsMasterProtein" "P22234" "Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase OS=Homo sapiens OX=9606 GN=PAICS PE=1 SV=3" "0.000" "False" "40.648" "28" "10" "23" "10" "425" "47.0" "7.23" "77.63" "10" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00731, Pf01259" "10606" "ENSG00000128050" "PAICS" "E9PDH9; hsa:10606; P22234; Q68CQ5" "Metabolic reprogramming in colon cancer" "Purine ribonucleoside monophosphate biosynthesis" "2" "0" "0.971" "0.983" "0.989" "0.971" "0.946" "0.932" "0.929" "0.963" "0.935" "2517.8" "2444.9" "2474.8" "2490.1" "2445.3" "2380.9" "2347.7" "2339.7" "2423.8" "2354.6" "" "" "" "" "" "" "" "" "" "" "2359.2" "2023.2" "2297.5" "1924.9" "2084.3" "2274.7" "2145.2" "2077.4" "2423.8" "2267.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4267649636453152821" "False" "High" "IsMasterProtein" "P16949" "Stathmin OS=Homo sapiens OX=9606 GN=STMN1 PE=1 SV=3" "0.000" "False" "40.626" "46" "8" "47" "8" "149" "17.3" "5.97" "138.74" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00836" "3925" "ENSG00000117632" "STMN1" "A2A2D1; B2R4E7; B7Z8N4; D3DPJ5; hsa:3925; P16949" "Microtubule cytoskeleton regulation; Retinoblastoma gene in cancer; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; IL-18 signaling pathway" "Nuclear signaling by ERBB4" "7" "0" "1.013" "0.981" "0.938" "0.951" "0.908" "0.880" "0.944" "0.896" "0.912" "3680.4" "3727.1" "3611.9" "3452.2" "3501.4" "3343.0" "3239.5" "3474.5" "3297.6" "3355.4" "" "" "" "" "" "" "" "" "" "" "3448.5" "3084.1" "3353.2" "2668.7" "2984.5" "3193.9" "2960.0" "3085.0" "3297.6" "3230.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8496601930648358283" "False" "High" "IsMasterProtein" "Q5T6F2" "Ubiquitin-associated protein 2 OS=Homo sapiens OX=9606 GN=UBAP2 PE=1 SV=1" "0.000" "False" "40.557" "13" "13" "16" "13" "1119" "117.0" "7.34" "54.39" "13" "other biological processes" "nucleus;other cell component" "" "Pf12478" "55833" "ENSG00000137073" "UBAP2" "hsa:55833; Q2M2R4; Q5JV03; Q5T6F2; Q6PK34; Q8NC94; Q9P237" "" "" "0" "0" "0.977" "0.981" "0.942" "0.998" "0.968" "0.972" "0.987" "0.992" "0.963" "2450.6" "2394.2" "2403.8" "2309.6" "2446.4" "2373.2" "2382.7" "2418.9" "2432.0" "2359.4" "" "" "" "" "" "" "" "" "" "" "2296.2" "1981.2" "2231.6" "1785.4" "2085.3" "2267.4" "2177.1" "2147.7" "2432.0" "2271.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3985188646102169391" "False" "High" "IsMasterProtein" "P53041" "Serine/threonine-protein phosphatase 5 OS=Homo sapiens OX=9606 GN=PPP5C PE=1 SV=1" "0.000" "False" "40.527" "28" "12" "15" "12" "499" "56.8" "6.28" "46.14" "12" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00149, Pf00515, Pf08321" "5536" "ENSG00000011485" "PPP5C" "hsa:5536; P53041; Q16722; Q53XV2" "MAPK signaling pathway; ATM signaling in development and disease" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Negative regulation of MAPK pathway; ESR-mediated signaling" "5" "0" "1.000" "0.965" "0.995" "0.931" "1.064" "0.933" "0.924" "0.994" "1.017" "1387.1" "1386.5" "1338.8" "1380.0" "1290.8" "1476.2" "1293.6" "1281.9" "1378.3" "1410.9" "" "" "" "" "" "" "" "" "" "" "1299.7" "1147.3" "1242.9" "1066.8" "1100.2" "1410.4" "1182.0" "1138.2" "1378.3" "1358.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1229807806236447203" "False" "High" "IsMasterProtein" "Q7Z7L1" "Schlafen family member 11 OS=Homo sapiens OX=9606 GN=SLFN11 PE=1 SV=2" "0.000" "False" "40.480" "17" "15" "16" "12" "901" "102.8" "7.77" "46.77" "15" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04326, Pf09848, Pf17057, Pf21026" "91607" "ENSG00000172716" "SLFN11" "E1P643; hsa:91607; Q7Z7L1; Q8N3S8; Q8N762; Q8TEE0" "17q12 copy number variation syndrome" "" "1" "2" "1.012" "1.036" "0.952" "0.994" "1.070" "0.917" "0.946" "0.963" "1.026" "2604.9" "2636.4" "2697.5" "2478.8" "2588.4" "2787.2" "2388.2" "2465.0" "2509.6" "2672.8" "" "" "" "" "" "" "" "" "" "" "2440.8" "2181.6" "2504.3" "1916.3" "2206.3" "2662.9" "2182.2" "2188.7" "2509.6" "2573.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2495561624923528868" "False" "High" "IsMasterProtein" "Q10567" "AP-1 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP1B1 PE=1 SV=3" "0.000" "False" "40.477" "15" "13" "20" "5" "949" "104.5" "5.06" "66.02" "13" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02883, Pf09066" "162" "ENSG00000100280" "AP1B1" "C9JRD1; F8WDL0; hsa:162; P78436; Q10567; Q20WL3; Q86X54" "" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "4" "0" "1.072" "1.047" "1.086" "1.051" "1.052" "1.086" "1.048" "1.100" "1.045" "410.4" "439.8" "429.7" "445.7" "431.3" "431.5" "445.7" "429.9" "451.2" "428.6" "" "" "" "" "" "" "" "" "" "" "384.5" "363.9" "398.9" "344.6" "367.6" "412.3" "407.2" "381.7" "451.2" "412.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4945442823809026460" "False" "High" "IsMasterProtein" "O95861" "3'(2'),5'-bisphosphate nucleotidase 1 OS=Homo sapiens OX=9606 GN=BPNT1 PE=1 SV=1" "0.000" "False" "40.464" "31" "9" "18" "9" "308" "33.4" "5.69" "56.87" "9" "other metabolic processes;developmental processes" "cytosol" "other molecular function" "Pf00459" "10380" "ENSG00000162813" "BPNT1" "A8K7C8; B4DPS5; B4DUS9; D3DTA9; hsa:10380; O95861; Q8WVL5; Q9UGJ3" "" "Cytosolic sulfonation of small molecules" "1" "0" "0.912" "0.951" "0.913" "0.919" "0.950" "0.908" "0.945" "0.941" "0.935" "1544.7" "1409.1" "1468.9" "1410.1" "1419.9" "1468.2" "1403.3" "1459.6" "1453.2" "1444.6" "" "" "" "" "" "" "" "" "" "" "1447.4" "1166.0" "1363.7" "1090.1" "1210.3" "1402.7" "1282.2" "1295.9" "1453.2" "1390.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1756983135160374971" "False" "High" "IsMasterProtein" "Q8NBJ5" "Procollagen galactosyltransferase 1 OS=Homo sapiens OX=9606 GN=COLGALT1 PE=1 SV=1" "0.000" "False" "40.459" "25" "16" "18" "16" "622" "71.6" "7.31" "48.40" "16" "cell organization and biogenesis;other biological processes" "ER/Golgi" "other molecular function" "Pf01755, Pf13704" "79709" "ENSG00000130309" "COLGALT1" "hsa:79709; Q8NBJ5; Q8NC64" "Type I collagen synthesis in the context of osteogenesis imperfecta" "Collagen biosynthesis and modifying enzymes" "2" "0" "1.018" "0.998" "1.080" "1.031" "0.981" "0.996" "0.972" "0.959" "0.996" "2033.7" "2070.9" "2030.4" "2195.6" "2096.4" "1995.6" "2024.9" "1976.8" "1951.0" "2025.5" "" "" "" "" "" "" "" "" "" "" "1905.6" "1713.6" "1885.0" "1697.3" "1786.9" "1906.6" "1850.2" "1755.2" "1951.0" "1950.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-917642798524543660" "False" "High" "IsMasterProtein" "P52566" "Rho GDP-dissociation inhibitor 2 OS=Homo sapiens OX=9606 GN=ARHGDIB PE=1 SV=3" "0.000" "False" "40.457" "57" "12" "41" "12" "201" "23.0" "5.21" "119.09" "12" "signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf02115" "397" "ENSG00000111348" "ARHGDIB" "B5BU79; hsa:397; P52566" "Fas ligand pathway and stress induction of heat shock proteins; Vasopressin-regulated water reabsorption; G13 signaling pathway" "RHOA GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; CDC42 GTPase cycle; RAC3 GTPase cycle; RHOH GTPase cycle" "9" "0" "0.990" "0.965" "0.894" "0.972" "0.949" "0.815" "0.888" "0.898" "0.922" "3640.2" "3604.9" "3514.4" "3254.1" "3539.5" "3455.0" "2967.6" "3233.4" "3270.0" "3354.9" "" "" "" "" "" "" "" "" "" "" "3410.9" "2983.0" "3262.6" "2515.5" "3017.0" "3301.0" "2711.6" "2871.0" "3270.0" "3230.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "654081652263858131" "False" "High" "IsMasterProtein" "Q12905" "Interleukin enhancer-binding factor 2 OS=Homo sapiens OX=9606 GN=ILF2 PE=1 SV=2" "0.000" "False" "40.402" "31" "11" "21" "11" "390" "43.0" "5.26" "85.84" "11" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf07528, Pf20965" "3608" "ENSG00000143621" "ILF2" "A6NDB0; B2R8G7; hsa:3608; Q12905; Q5SR10; Q5SR11; Q7L7R3; Q9BWD4; Q9P1N0" "B cell receptor signaling pathway" "Neutrophil degranulation; PKR-mediated signaling" "3" "0" "1.135" "1.030" "1.029" "1.069" "1.101" "0.972" "1.110" "1.147" "1.065" "1180.0" "1338.8" "1215.2" "1213.6" "1260.9" "1298.9" "1147.5" "1310.0" "1353.2" "1256.2" "" "" "" "" "" "" "" "" "" "" "1105.6" "1107.8" "1128.1" "938.2" "1074.7" "1241.0" "1048.5" "1163.2" "1353.2" "1209.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7926750901402698685" "False" "High" "IsMasterProtein" "Q9UKG1" "DCC-interacting protein 13-alpha OS=Homo sapiens OX=9606 GN=APPL1 PE=1 SV=1" "0.000" "False" "40.338" "22" "12" "14" "12" "709" "79.6" "5.41" "48.42" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00640, Pf16746" "26060" "ENSG00000157500" "APPL1" "hsa:26060; Q9P2B9; Q9UKG1" "Follicle stimulating hormone (FSH) signaling pathway; Chromosomal and microsatellite instability in colorectal cancer" "Caspase activation via Dependence Receptors in the absence of ligand" "3" "0" "0.925" "0.955" "0.966" "0.957" "0.979" "0.957" "0.934" "0.895" "0.939" "1211.3" "1120.9" "1156.2" "1170.5" "1159.3" "1185.4" "1158.7" "1131.6" "1083.8" "1137.7" "" "" "" "" "" "" "" "" "" "" "1135.0" "927.5" "1073.4" "904.8" "988.2" "1132.5" "1058.8" "1004.7" "1083.8" "1095.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4858909322532710110" "False" "High" "IsMasterProtein" "Q16881" "Thioredoxin reductase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TXNRD1 PE=1 SV=3" "0.000" "False" "40.334" "19" "11" "19" "11" "649" "70.9" "7.39" "62.19" "11" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00462, Pf02852, Pf07992" "7296" "ENSG00000198431" "TXNRD1" "B7Z1F4; B7Z3Y8; B7Z904; E9PMY9; F5H780; hsa:7296; Q16881; Q6FI31; Q6VB40; Q6VB41; Q6VB42; Q6VBP2; Q6VBP3; Q6VBP4; Q6VBP5; Q6VBP9; Q6VBQ0; Q6YNQ1; Q76P53; Q7LA96; Q8WVC8; Q99475; Q9UES8; Q9UH79" "Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Selenium metabolism and selenoproteins; Nuclear receptors meta-pathway; NRF2 pathway; Oxidative stress response; Ferroptosis" "PPARA activates gene expression; Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates; NFE2L2 regulating anti-oxidant/detoxification enzymes; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se; Uptake and function of diphtheria toxin; Metabolism of ingested MeSeO2H into MeSeH" "16" "0" "0.923" "0.959" "0.975" "0.937" "0.913" "0.907" "0.950" "0.900" "0.920" "2700.2" "2492.4" "2590.1" "2633.2" "2528.9" "2464.0" "2447.9" "2565.5" "2431.4" "2483.9" "" "" "" "" "" "" "" "" "" "" "2530.1" "2062.5" "2404.5" "2035.6" "2155.6" "2354.1" "2236.8" "2277.9" "2431.4" "2391.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1447147241946060131" "False" "High" "IsMasterProtein" "P61604" "10 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPE1 PE=1 SV=2" "0.000" "False" "40.325" "79" "10" "37" "10" "102" "10.9" "8.92" "104.88" "10" "protein metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf00166" "3336" "ENSG00000115541" "HSPE1" "hsa:3336; O95421; P61604; Q04984; Q53X54; Q9UDH0" "" "RHOG GTPase cycle" "1" "0" "1.046" "1.020" "0.988" "0.997" "0.944" "1.006" "1.022" "0.980" "0.954" "4323.9" "4520.7" "4409.4" "4270.5" "4311.0" "4083.6" "4347.7" "4418.5" "4237.3" "4124.9" "" "" "" "" "" "" "" "" "" "" "4051.5" "3740.8" "4093.5" "3301.3" "3674.6" "3901.5" "3972.7" "3923.2" "4237.3" "3971.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4317219429199659424" "False" "High" "IsMasterProtein" "Q9H6Z4" "Ran-binding protein 3 OS=Homo sapiens OX=9606 GN=RANBP3 PE=1 SV=1" "0.000" "False" "40.288" "26" "12" "17" "12" "567" "60.2" "4.78" "59.23" "12" "transport" "nucleus;other cell component" "other molecular function" "Pf00638" "8498" "ENSG00000031823" "RANBP3" "B2RAT8; hsa:8498; O60405; O75759; O75760; Q9BT47; Q9H6Z4; Q9UG74" "" "" "0" "0" "1.014" "0.992" "1.009" "1.009" "1.009" "1.021" "1.006" "1.019" "0.980" "2472.0" "2507.6" "2451.3" "2493.4" "2494.2" "2494.6" "2523.4" "2486.3" "2520.2" "2423.7" "" "" "" "" "" "" "" "" "" "" "2316.3" "2075.0" "2275.7" "1927.5" "2126.0" "2383.3" "2305.8" "2207.6" "2520.2" "2333.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "523405854747225660" "False" "High" "IsMasterProtein" "Q16222" "UDP-N-acetylhexosamine pyrophosphorylase OS=Homo sapiens OX=9606 GN=UAP1 PE=1 SV=3" "0.000" "False" "40.285" "27" "13" "26" "11" "522" "58.7" "6.33" "81.11" "13" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf01704" "6675" "ENSG00000117143" "UAP1" "B2R6R8; hsa:6675; Q16222; Q5VTA9; Q5VTB0; Q5VTB1; Q96GM2" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "1" "0.898" "0.954" "0.919" "0.904" "0.928" "0.918" "0.893" "0.905" "0.908" "1634.6" "1467.7" "1558.8" "1501.8" "1477.0" "1516.7" "1500.4" "1460.1" "1478.7" "1484.5" "" "" "" "" "" "" "" "" "" "" "1531.6" "1214.5" "1447.1" "1161.0" "1259.0" "1449.0" "1371.0" "1296.4" "1478.7" "1429.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2292593222020041360" "False" "High" "IsMasterProtein" "Q92925" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 OS=Homo sapiens OX=9606 GN=SMARCD2 PE=1 SV=3" "0.000" "False" "40.247" "28" "12" "17" "10" "531" "58.9" "9.64" "47.93" "12" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02201" "6603" "ENSG00000108604" "SMARCD2" "A5PLL5; A6NNQ7; B4DV56; B4E1R6; hsa:6603; Q7L2I6; Q92925; Q9UHZ1" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "6" "0" "0.927" "1.019" "1.014" "1.007" "0.939" "0.986" "0.990" "1.006" "0.981" "1354.6" "1255.8" "1381.0" "1373.3" "1363.8" "1271.8" "1335.2" "1341.0" "1362.2" "1329.1" "" "" "" "" "" "" "" "" "" "" "1269.3" "1039.2" "1282.0" "1061.6" "1162.5" "1215.1" "1220.0" "1190.7" "1362.2" "1279.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5370453687865171634" "False" "High" "IsMasterProtein" "P39880" "Homeobox protein cut-like 1 OS=Homo sapiens OX=9606 GN=CUX1 PE=1 SV=3" "0.000" "False" "40.194" "8" "13" "16" "13" "1505" "164.1" "5.90" "46.98" "13" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf02376" "1523" "ENSG00000257923" "CUX1" "B3KV79; J3KQV9; P39880; Q6NYH4; Q75LE5; Q75MT2; Q75MT3; Q86UJ7; Q9UEV5" "" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "2" "0" "0.997" "1.015" "1.061" "1.081" "1.050" "1.014" "1.050" "0.994" "1.040" "1146.0" "1142.4" "1163.2" "1215.5" "1238.9" "1203.6" "1161.9" "1203.0" "1139.3" "1192.0" "" "" "" "" "" "" "" "" "" "" "1073.8" "945.3" "1079.9" "939.6" "1056.0" "1149.9" "1061.7" "1068.1" "1139.3" "1147.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3428809261446700766" "False" "High" "IsMasterProtein" "Q9UNN5" "FAS-associated factor 1 OS=Homo sapiens OX=9606 GN=FAF1 PE=1 SV=2" "0.000" "False" "40.134" "20" "14" "21" "14" "650" "73.9" "4.88" "63.37" "14" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00789, Pf14555, Pf21021" "11124" "ENSG00000185104" "FAF1" "hsa:11124; Q549F0; Q9UF34; Q9UNN5; Q9UNT3; Q9Y2Z3" "Retinoblastoma gene in cancer; Fas ligand pathway and stress induction of heat shock proteins; VEGFA-VEGFR2 signaling" "" "3" "0" "0.956" "0.991" "0.985" "0.988" "0.981" "0.954" "0.991" "0.962" "0.971" "2385.0" "2279.4" "2362.3" "2349.7" "2356.4" "2339.9" "2274.8" "2364.0" "2294.2" "2316.7" "" "" "" "" "" "" "" "" "" "" "2234.7" "1886.2" "2193.1" "1816.4" "2008.5" "2235.6" "2078.5" "2099.0" "2294.2" "2230.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2458252490920426752" "False" "High" "IsMasterProtein" "P16402" "Histone H1.3 OS=Homo sapiens OX=9606 GN=H1-3 PE=1 SV=2" "0.000" "False" "40.129" "40" "11" "23" "4" "221" "22.3" "11.02" "82.37" "11" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3007" "ENSG00000124575" "H1-3" "B2R751; hsa:3007; P16402; Q2M2I2" "" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "2" "0" "1.029" "0.913" "0.782" "0.944" "0.934" "0.922" "0.920" "0.919" "0.929" "351.1" "361.1" "320.6" "274.7" "331.3" "328.0" "323.7" "322.9" "322.5" "326.1" "" "" "" "" "" "" "" "" "" "" "328.9" "298.8" "297.7" "212.4" "282.4" "313.4" "295.7" "286.7" "322.5" "314.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8623682461858759698" "False" "High" "IsMasterProtein" "P54578" "Ubiquitin carboxyl-terminal hydrolase 14 OS=Homo sapiens OX=9606 GN=USP14 PE=1 SV=3" "0.000" "False" "40.061" "27" "12" "21" "12" "494" "56.0" "5.30" "65.48" "12" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00443" "9097" "ENSG00000101557" "USP14" "B7Z4N8; hsa:9097; J3QRZ5; P54578; Q53XY5" "" "Ub-specific processing proteases; Regulation of NF-kappa B signaling" "2" "0" "0.943" "0.970" "0.937" "0.952" "0.939" "0.945" "0.929" "0.963" "0.937" "2513.8" "2370.5" "2439.5" "2355.5" "2392.9" "2360.1" "2375.0" "2336.5" "2420.3" "2356.6" "" "" "" "" "" "" "" "" "" "" "2355.5" "1961.6" "2264.7" "1820.9" "2039.6" "2254.9" "2170.1" "2074.6" "2420.3" "2269.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1567690974661695744" "False" "High" "IsMasterProtein" "Q9NY65" "Tubulin alpha-8 chain OS=Homo sapiens OX=9606 GN=TUBA8 PE=1 SV=1" "0.000" "False" "40.059" "27" "10" "30" "1" "449" "50.1" "5.06" "98.94" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "51807" "ENSG00000183785" "TUBA8" "B2RCX2; B3KPW9; B4DWG3; hsa:51807; Q2M3N4; Q9NY65" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; MHC class II antigen presentation; RHO GTPases Activate Formins; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; HCMV Early Events; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; EML4 and NUDC in mitotic spindle formation; Kinesins; Recycling pathway of L1; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; Cilium Assembly; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; PKR-mediated signaling" "32" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "516954531369469772" "False" "High" "IsMasterProtein" "P60900" "Proteasome subunit alpha type-6 OS=Homo sapiens OX=9606 GN=PSMA6 PE=1 SV=1" "0.000" "False" "40.044" "44" "10" "23" "10" "246" "27.4" "6.76" "78.95" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00227, Pf10584" "5687" "ENSG00000100902" "PSMA6" "B2R7J9; B4DQR4; B4DXJ9; hsa:5687; P34062; P60900; Q6IB60" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Neddylation; KEAP1-NFE2L2 pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.989" "0.993" "0.951" "0.933" "0.981" "0.897" "0.954" "1.002" "0.949" "3294.1" "3256.3" "3271.0" "3133.3" "3074.1" "3230.7" "2954.6" "3141.8" "3299.5" "3126.3" "" "" "" "" "" "" "" "" "" "" "3086.5" "2694.5" "3036.7" "2422.2" "2620.3" "3086.6" "2699.7" "2789.6" "3299.5" "3010.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2009427819375188157" "False" "High" "IsMasterProtein" "P62333" "26S proteasome regulatory subunit 10B OS=Homo sapiens OX=9606 GN=PSMC6 PE=1 SV=1" "0.000" "False" "40.021" "42" "14" "17" "14" "389" "44.1" "7.49" "53.24" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5706" "ENSG00000100519" "PSMC6" "B2R975; hsa:5706; P49719; P62333; Q6IBU3; Q92524" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "Ub-specific processing proteases; Antigen processing: Ubiquitination & Proteasome degradation; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; SARS-CoV-1 targets host intracellular signalling and regulatory pathways" "65" "0" "1.000" "0.979" "1.017" "0.991" "0.990" "0.991" "0.988" "0.942" "0.929" "1358.0" "1358.3" "1329.2" "1381.4" "1345.9" "1344.0" "1345.2" "1341.2" "1279.2" "1261.5" "" "" "" "" "" "" "" "" "" "" "1272.4" "1124.0" "1234.0" "1067.9" "1147.2" "1284.0" "1229.2" "1190.9" "1279.2" "1214.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6148920523022948324" "False" "High" "IsMasterProtein" "P35606" "Coatomer subunit beta' OS=Homo sapiens OX=9606 GN=COPB2 PE=1 SV=2" "0.000" "False" "40.018" "15" "13" "21" "13" "906" "102.4" "5.27" "53.51" "13" "transport" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00400, Pf04053" "9276" "ENSG00000184432" "COPB2" "B4DZI8; hsa:9276; P35606" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "0.966" "1.039" "0.974" "0.997" "0.992" "0.965" "0.953" "0.969" "1.000" "2213.1" "2138.9" "2300.4" "2156.3" "2206.0" "2195.8" "2135.6" "2108.1" "2145.1" "2213.5" "" "" "" "" "" "" "" "" "" "" "2073.7" "1769.9" "2135.6" "1666.9" "1880.4" "2097.9" "1951.3" "1871.8" "2145.1" "2131.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4751284344252295029" "False" "High" "IsMasterProtein" "P06748" "Nucleophosmin OS=Homo sapiens OX=9606 GN=NPM1 PE=1 SV=2" "0.000" "False" "40.002" "41" "11" "34" "11" "294" "32.6" "4.78" "98.25" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function" "Pf03066, Pf16276" "4869" "ENSG00000181163" "NPM1" "A8K3N7; B5BU00; D3DQL6; hsa:4869; P06748; P08693; Q12826; Q13440; Q13441; Q14115; Q5EU94; Q5EU95; Q5EU96; Q5EU97; Q5EU98; Q5EU99; Q6V962; Q8WTW5; Q96AT6; Q96DC4; Q96EA5; Q9BYG9; Q9UDJ7" "" "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; PKR-mediated signaling; Nuclear import of Rev protein; Deposition of new CENPA-containing nucleosomes at the centromere; SUMOylation of transcription cofactors; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; Nuclear events stimulated by ALK signaling in cancer; SARS-CoV-1-host interactions" "10" "0" "1.098" "1.086" "1.001" "1.125" "1.071" "1.057" "1.130" "1.018" "1.045" "1834.6" "2013.7" "1992.4" "1836.9" "2064.8" "1965.3" "1938.9" "2072.8" "1868.5" "1917.8" "" "" "" "" "" "" "" "" "" "" "1719.0" "1666.3" "1849.7" "1420.0" "1760.0" "1877.6" "1771.6" "1840.4" "1868.5" "1846.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6490484038664760531" "False" "High" "IsMasterProtein" "Q13283" "Ras GTPase-activating protein-binding protein 1 OS=Homo sapiens OX=9606 GN=G3BP1 PE=1 SV=1" "0.000" "False" "39.896" "32" "11" "29" "11" "466" "52.1" "5.52" "89.48" "11" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00076, Pf02136" "10146" "ENSG00000145907" "G3BP1" "hsa:10146; Q13283; Q5HYE9" "7q11.23 distal copy number variation; HDAC6 interactions in the central nervous system" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "3" "0" "1.041" "1.047" "1.078" "1.068" "1.084" "1.031" "1.058" "1.063" "1.051" "1468.8" "1529.2" "1538.6" "1584.0" "1568.0" "1591.5" "1513.8" "1553.3" "1561.0" "1543.4" "" "" "" "" "" "" "" "" "" "" "1376.3" "1265.4" "1428.4" "1224.5" "1336.5" "1520.6" "1383.2" "1379.1" "1561.0" "1486.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3249613255715037073" "False" "High" "IsMasterProtein" "P30041" "Peroxiredoxin-6 OS=Homo sapiens OX=9606 GN=PRDX6 PE=1 SV=3" "0.000" "False" "39.895" "48" "10" "27" "10" "224" "25.0" "6.38" "82.67" "10" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00578, Pf10417" "9588" "ENSG00000117592" "PRDX6" "A8JZY7; hsa:9588; P30041; P32077; Q5TAH4; Q5ZEZ8" "Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling" "Neutrophil degranulation; Detoxification of Reactive Oxygen Species" "5" "0" "0.906" "0.964" "0.939" "0.956" "0.992" "0.887" "0.942" "0.933" "0.931" "2918.0" "2642.2" "2812.1" "2740.6" "2788.3" "2895.0" "2586.8" "2749.5" "2721.7" "2715.3" "" "" "" "" "" "" "" "" "" "" "2734.1" "2186.4" "2610.7" "2118.6" "2376.6" "2765.9" "2363.7" "2441.3" "2721.7" "2614.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3565723958770546681" "False" "High" "IsMasterProtein" "Q08378" "Golgin subfamily A member 3 OS=Homo sapiens OX=9606 GN=GOLGA3 PE=1 SV=2" "0.000" "False" "39.871" "9" "12" "13" "12" "1498" "167.3" "5.44" "48.56" "12" "" "other membranes;cytosol;ER/Golgi;nucleus" "" "" "2802" "ENSG00000090615" "GOLGA3" "A5PKX6; hsa:2802; O43241; Q08378; Q6P9C7; Q86XW3; Q8TDA9; Q8WZA3" "" "RND2 GTPase cycle" "1" "0" "1.013" "0.945" "1.062" "1.038" "1.036" "1.035" "1.022" "0.968" "1.049" "1181.9" "1197.3" "1117.2" "1255.5" "1226.4" "1224.9" "1222.7" "1208.5" "1144.4" "1239.3" "" "" "" "" "" "" "" "" "" "" "1107.4" "990.8" "1037.1" "970.5" "1045.3" "1170.2" "1117.2" "1073.0" "1144.4" "1193.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5029706333006790084" "False" "High" "IsMasterProtein" "Q5VT52" "Regulation of nuclear pre-mRNA domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RPRD2 PE=1 SV=1" "0.000" "False" "39.867" "12" "14" "16" "14" "1461" "155.9" "7.42" "54.12" "14" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04818" "23248" "ENSG00000163125" "RPRD2" "A8K6N8; B3KPT1; B4E2Q6; hsa:23248; O75048; Q5VT51; Q5VT52; Q5VT53; Q6MZL4; Q86XD2; Q9P0D7" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "1.014" "0.981" "1.027" "1.107" "1.099" "1.099" "1.092" "1.092" "1.099" "2140.6" "2171.4" "2100.1" "2197.6" "2370.0" "2352.5" "2352.9" "2338.1" "2338.1" "2352.0" "" "" "" "" "" "" "" "" "" "" "2005.7" "1796.8" "1949.7" "1698.8" "2020.1" "2247.6" "2150.0" "2076.0" "2338.1" "2264.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7029493779746441827" "False" "High" "IsMasterProtein" "Q7L1Q6" "eIF5-mimic protein 2 OS=Homo sapiens OX=9606 GN=BZW1 PE=1 SV=1" "0.000" "False" "39.853" "27" "13" "29" "12" "419" "48.0" "5.92" "89.02" "13" "other biological processes" "other cell component" "" "Pf02020" "9689" "ENSG00000082153" "BZW1" "B4DLZ8; B4DWF7; hsa:9689; Q14281; Q15394; Q7L1Q6; Q9BUY0" "" "" "0" "0" "0.975" "1.029" "0.960" "0.946" "0.952" "0.915" "0.963" "0.966" "0.951" "3112.7" "3036.2" "3202.3" "2989.7" "2945.2" "2963.3" "2849.6" "2998.1" "3007.1" "2960.1" "" "" "" "" "" "" "" "" "" "" "2916.6" "2512.4" "2972.9" "2311.1" "2510.4" "2831.1" "2603.8" "2662.0" "3007.1" "2850.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7622231560690593168" "False" "High" "IsMasterProtein" "Q13043" "Serine/threonine-protein kinase 4 OS=Homo sapiens OX=9606 GN=STK4 PE=1 SV=2" "0.000" "False" "39.791" "26" "11" "19" "4" "487" "55.6" "5.07" "49.65" "11" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf11629" "6789" "ENSG00000101109" "STK4" "B2RCR8; hsa:6789; Q13043; Q15802; Q4G156; Q5H982; Q6PD60; Q9BR32; Q9NTZ4" "MAPK signaling pathway; Ras signaling; Non-small cell lung cancer" "Signaling by Hippo" "4" "6" "1.006" "1.005" "1.107" "1.019" "1.021" "1.001" "0.983" "0.974" "1.025" "1431.5" "1440.7" "1439.2" "1585.2" "1458.1" "1460.8" "1432.8" "1407.0" "1394.2" "1467.9" "" "" "" "" "" "" "" "" "" "" "1341.3" "1192.2" "1336.1" "1225.5" "1242.9" "1395.7" "1309.2" "1249.3" "1394.2" "1413.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7480340352347879805" "False" "High" "IsMasterProtein" "Q99459" "Cell division cycle 5-like protein OS=Homo sapiens OX=9606 GN=CDC5L PE=1 SV=2" "0.000" "False" "39.777" "18" "12" "13" "12" "802" "92.2" "8.18" "44.60" "12" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11831, Pf13921" "988" "ENSG00000096401" "CDC5L" "hsa:988; Q76N46; Q99459; Q99974" "" "mRNA Splicing - Major Pathway" "1" "0" "0.997" "1.049" "1.025" "1.067" "1.033" "1.170" "1.189" "1.162" "1.120" "872.3" "870.1" "914.7" "894.0" "930.5" "901.2" "1020.9" "1036.8" "1014.1" "977.2" "" "" "" "" "" "" "" "" "" "" "817.4" "720.0" "849.2" "691.1" "793.1" "861.0" "932.9" "920.6" "1014.1" "940.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4078763853778873139" "False" "High" "IsMasterProtein" "O95816" "BAG family molecular chaperone regulator 2 OS=Homo sapiens OX=9606 GN=BAG2 PE=1 SV=1" "0.000" "False" "39.760" "48" "11" "21" "11" "211" "23.8" "6.70" "64.10" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "" "9532" "ENSG00000112208" "BAG2" "B4DXE2; hsa:9532; O95816; Q08AS9; Q6FID0" "Pleural mesothelioma" "Regulation of HSF1-mediated heat shock response" "2" "0" "1.002" "0.953" "0.990" "0.968" "1.039" "0.926" "0.937" "0.943" "0.972" "2363.1" "2367.6" "2251.5" "2338.9" "2288.4" "2454.1" "2188.7" "2214.6" "2227.8" "2295.8" "" "" "" "" "" "" "" "" "" "" "2214.2" "1959.1" "2090.2" "1808.1" "1950.6" "2344.7" "1999.9" "1966.3" "2227.8" "2210.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4886602285452216196" "False" "High" "IsMasterProtein" "Q92696" "Geranylgeranyl transferase type-2 subunit alpha OS=Homo sapiens OX=9606 GN=RABGGTA PE=1 SV=2" "0.000" "False" "39.745" "21" "13" "16" "13" "567" "65.0" "5.67" "49.94" "13" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00560, Pf01239, Pf07711" "5875" "ENSG00000100949; ENSG00000285193" "RABGGTA" "A8K5N2; D3DS69; hsa:5875; Q92696" "" "RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "2" "0" "1.058" "1.012" "1.053" "1.001" "0.966" "0.984" "0.996" "0.989" "0.997" "554.0" "585.9" "560.8" "583.2" "554.7" "535.3" "544.9" "551.5" "547.9" "552.3" "" "" "" "" "" "" "" "" "" "" "519.1" "484.9" "520.6" "450.8" "472.8" "511.4" "497.9" "489.7" "547.9" "531.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1487358643357756863" "False" "High" "IsMasterProtein" "P41214" "Eukaryotic translation initiation factor 2D OS=Homo sapiens OX=9606 GN=EIF2D PE=1 SV=3" "0.000" "False" "39.733" "29" "13" "15" "13" "584" "64.7" "7.65" "49.06" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01253, Pf17832" "1939" "ENSG00000143486" "EIF2D" "hsa:1939; P41214; Q5SY40; Q8IXV3; Q96DG3; Q96TG7; Q9NR27; Q9NSN0; Q9NV18; Q9NZ21" "" "" "0" "0" "0.932" "0.963" "0.954" "0.971" "0.990" "0.877" "0.869" "0.850" "0.958" "1557.0" "1450.5" "1500.1" "1484.9" "1512.5" "1541.3" "1364.8" "1353.8" "1323.4" "1490.9" "" "" "" "" "" "" "" "" "" "" "1458.9" "1200.3" "1392.6" "1147.9" "1289.2" "1472.6" "1247.1" "1202.1" "1323.4" "1435.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7075703887839209806" "False" "High" "IsMasterProtein" "Q14CX7" "N-alpha-acetyltransferase 25, NatB auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA25 PE=1 SV=1" "0.000" "False" "39.716" "16" "16" "24" "16" "972" "112.2" "6.64" "54.61" "16" "" "cytosol;ER/Golgi;other cell component" "" "Pf09797" "80018" "ENSG00000111300" "NAA25" "A0JLU7; hsa:80018; Q14CX7; Q6MZH1; Q7Z4N6; Q9H911" "" "" "0" "0" "0.929" "0.974" "0.973" "0.955" "0.979" "0.974" "0.980" "0.953" "0.970" "2623.6" "2436.9" "2554.5" "2554.1" "2504.9" "2568.7" "2555.6" "2572.3" "2501.5" "2545.0" "" "" "" "" "" "" "" "" "" "" "2458.3" "2016.5" "2371.5" "1974.4" "2135.1" "2454.1" "2335.1" "2283.9" "2501.5" "2450.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1412779903324820773" "False" "High" "IsMasterProtein" "Q8TF42" "Ubiquitin-associated and SH3 domain-containing protein B OS=Homo sapiens OX=9606 GN=UBASH3B PE=1 SV=2" "0.000" "False" "39.697" "22" "13" "19" "13" "649" "72.6" "6.93" "61.42" "13" "cell adhesion;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00300, Pf00627, Pf14604" "84959" "ENSG00000154127" "UBASH3B" "hsa:84959; Q53GT5; Q53GT8; Q8NBV7; Q8TF42; Q96IG9; Q96NZ2" "" "" "0" "0" "0.944" "1.009" "0.967" "0.989" "0.942" "0.994" "0.929" "0.973" "0.952" "1772.1" "1672.2" "1788.3" "1713.8" "1752.6" "1668.9" "1762.3" "1645.8" "1724.4" "1687.8" "" "" "" "" "" "" "" "" "" "" "1660.5" "1383.7" "1660.2" "1324.9" "1493.9" "1594.5" "1610.3" "1461.3" "1724.4" "1625.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5905184492137342602" "False" "High" "IsMasterProtein" "P08559" "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Homo sapiens OX=9606 GN=PDHA1 PE=1 SV=3" "0.000" "False" "39.697" "30" "13" "22" "13" "390" "43.3" "8.06" "60.63" "13" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00676" "5160" "ENSG00000131828" "PDHA1" "A5YVE9; B2R5P7; B7Z3T7; B7Z3X5; hsa:5160; P08559; Q53H41; Q5JPT8; Q9NP12; Q9UBJ8; Q9UBU0; Q9UNG4; Q9UNG5" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Lipid metabolism pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways; TCA cycle in senescence; Neuroinflammation and glutamatergic signaling; Acetylcholine synthesis; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "17" "0" "0.979" "1.016" "1.042" "1.024" "1.035" "0.977" "1.031" "0.972" "1.006" "2041.2" "1997.3" "2074.1" "2127.3" "2090.5" "2113.6" "1994.3" "2105.1" "1984.1" "2053.4" "" "" "" "" "" "" "" "" "" "" "1912.6" "1652.8" "1925.6" "1644.5" "1781.9" "2019.3" "1822.3" "1869.1" "1984.1" "1977.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3468928122779261644" "False" "High" "IsMasterProtein" "P51398" "Small ribosomal subunit protein mS29 OS=Homo sapiens OX=9606 GN=DAP3 PE=1 SV=1" "0.000" "False" "39.649" "28" "10" "16" "10" "398" "45.5" "8.88" "51.32" "10" "protein metabolism;other metabolic processes;signal transduction" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf10236" "7818" "ENSG00000132676" "DAP3" "B4DP59; B4DY62; E7EM60; hsa:7818; P51398; Q13044; Q68CT7; Q96Q20" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.056" "1.084" "1.035" "1.029" "1.114" "1.020" "0.937" "1.007" "1.068" "703.1" "742.1" "762.2" "728.0" "723.4" "783.3" "717.0" "659.0" "708.2" "750.9" "" "" "" "" "" "" "" "" "" "" "658.8" "614.1" "707.6" "562.8" "616.6" "748.4" "655.1" "585.1" "708.2" "723.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-558081350695480590" "False" "High" "IsMasterProtein" "O43172" "U4/U6 small nuclear ribonucleoprotein Prp4 OS=Homo sapiens OX=9606 GN=PRPF4 PE=1 SV=2" "0.000" "False" "39.634" "25" "12" "13" "12" "522" "58.4" "7.42" "42.56" "12" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00400, Pf08799" "9128" "ENSG00000136875" "PRPF4" "hsa:9128; O43172; O43445; O43864; Q5T1M8; Q96DG2; Q96IK4" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.976" "1.059" "1.008" "1.030" "1.032" "1.053" "1.065" "1.036" "1.068" "2182.2" "2130.3" "2311.4" "2200.0" "2247.4" "2251.8" "2298.4" "2323.2" "2260.9" "2330.2" "" "" "" "" "" "" "" "" "" "" "2044.7" "1762.8" "2145.8" "1700.7" "1915.6" "2151.4" "2100.1" "2062.7" "2260.9" "2243.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6238619609280539619" "False" "High" "IsMasterProtein" "Q9NZW5" "Protein PALS2 OS=Homo sapiens OX=9606 GN=PALS2 PE=1 SV=2" "0.000" "False" "39.610" "24" "13" "17" "13" "540" "61.1" "6.18" "55.28" "13" "cell organization and biogenesis" "plasma membrane;other membranes;other cell component" "" "Pf00595, Pf00625, Pf02828, Pf07653" "51678" "ENSG00000105926" "PALS2" "A4D157; hsa:51678; Q9H0E1; Q9NZW5" "" "" "0" "0" "0.974" "1.014" "1.046" "1.013" "0.990" "0.992" "1.006" "0.973" "1.015" "2002.3" "1950.4" "2030.5" "2095.1" "2028.5" "1982.1" "1985.5" "2014.3" "1948.2" "2032.8" "" "" "" "" "" "" "" "" "" "" "1876.2" "1613.9" "1885.1" "1619.6" "1729.1" "1893.7" "1814.2" "1788.5" "1948.2" "1957.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1217217274349295091" "False" "High" "IsMasterProtein" "Q9Y4E8" "Ubiquitin carboxyl-terminal hydrolase 15 OS=Homo sapiens OX=9606 GN=USP15 PE=1 SV=3" "0.000" "False" "39.592" "14" "15" "19" "13" "981" "112.3" "5.22" "55.20" "15" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00443, Pf06337, Pf14533, Pf14836" "9958" "ENSG00000135655" "USP15" "hsa:9958; Q08AL5; Q9H8G9; Q9HCA6; Q9UNP0; Q9Y4E8; Q9Y5B5" "" "Ub-specific processing proteases; UCH proteinases; Downregulation of TGF-beta receptor signaling" "3" "1" "1.031" "1.036" "1.016" "1.002" "1.044" "0.958" "0.972" "0.989" "1.001" "2538.6" "2616.4" "2630.2" "2579.8" "2544.8" "2650.5" "2431.0" "2468.6" "2511.1" "2540.2" "" "" "" "" "" "" "" "" "" "" "2378.7" "2165.1" "2441.8" "1994.3" "2169.1" "2532.3" "2221.3" "2191.9" "2511.1" "2445.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5135985212415519925" "False" "High" "IsMasterProtein" "P43686" "26S proteasome regulatory subunit 6B OS=Homo sapiens OX=9606 GN=PSMC4 PE=1 SV=2" "0.000" "False" "39.561" "29" "13" "21" "13" "418" "47.3" "5.21" "71.63" "13" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5704" "ENSG00000013275; ENSG00000281221" "PSMC4" "hsa:5704; P43686; Q96FV5; Q9UBM3; Q9UEX3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "Assembly of the pre-replicative complex; Regulation of RAS by GAPs; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "1.007" "1.001" "1.004" "1.000" "1.024" "0.950" "1.011" "0.974" "1.000" "2139.9" "2155.3" "2143.2" "2147.9" "2139.6" "2191.5" "2032.5" "2163.3" "2083.3" "2141.0" "" "" "" "" "" "" "" "" "" "" "2005.1" "1783.5" "1989.6" "1660.4" "1823.7" "2093.7" "1857.2" "1920.8" "2083.3" "2061.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8109670193418590883" "False" "High" "IsMasterProtein" "O14641" "Segment polarity protein dishevelled homolog DVL-2 OS=Homo sapiens OX=9606 GN=DVL2 PE=1 SV=1" "0.000" "False" "39.490" "20" "12" "15" "8" "736" "78.9" "6.02" "50.11" "12" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00595, Pf00610, Pf00778, Pf02377, Pf12316" "1856" "ENSG00000004975" "DVL2" "D3DTN3; hsa:1856; O14641; Q53XM0" "Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Type 2 papillary renal cell carcinoma; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)" "Asymmetric localization of PCP proteins; Degradation of DVL; RHO GTPases Activate Formins; Cargo recognition for clathrin-mediated endocytosis; WNT mediated activation of DVL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping; Signaling by Hippo; WNT5A-dependent internalization of FZD4" "29" "4" "0.942" "0.962" "0.933" "0.938" "0.945" "1.036" "0.919" "0.869" "0.981" "2115.2" "1993.5" "2035.6" "1972.7" "1983.8" "1998.7" "2192.2" "1943.5" "1838.9" "2075.5" "" "" "" "" "" "" "" "" "" "" "1981.9" "1649.6" "1889.8" "1525.0" "1690.9" "1909.6" "2003.1" "1725.6" "1838.9" "1998.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "193290723324093172" "False" "High" "IsMasterProtein" "P33316" "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=DUT PE=1 SV=4" "0.000" "False" "39.386" "42" "9" "20" "9" "252" "26.5" "9.36" "69.14" "9" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "mitochondrion;nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf00692" "1854" "ENSG00000128951" "DUT" "A8K650; B4DPR5; hsa:1854; O14785; P33316; Q16708; Q16860; Q6FHN1; Q6NSA3; Q96Q81" "Pyrimidine metabolism" "" "1" "0" "1.545" "1.046" "1.290" "1.236" "0.779" "1.034" "1.056" "1.291" "1.134" "1175.7" "1816.9" "1229.3" "1516.9" "1453.6" "915.3" "1215.8" "1241.8" "1518.1" "1333.0" "" "" "" "" "" "" "" "" "" "" "1101.6" "1503.4" "1141.2" "1172.6" "1239.0" "874.5" "1110.9" "1102.6" "1518.1" "1283.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1852571755298916304" "False" "High" "IsMasterProtein" "Q9UKX7" "Nuclear pore complex protein Nup50 OS=Homo sapiens OX=9606 GN=NUP50 PE=1 SV=2" "0.000" "False" "39.380" "33" "14" "18" "14" "468" "50.1" "7.06" "51.10" "14" "transport" "other membranes;nucleus" "" "Pf00638, Pf08911" "10762" "ENSG00000093000" "NUP50" "B1AHA4; B2RB15; hsa:10762; O75644; Q8N6V5; Q9NPM9; Q9NPR6; Q9P1K5; Q9UKX7" "" "Rev-mediated nuclear export of HIV RNA; SUMOylation of DNA replication proteins; Regulation of HSF1-mediated heat shock response; snRNP Assembly; ISG15 antiviral mechanism; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "28" "0" "0.980" "1.047" "0.977" "1.061" "0.974" "1.078" "1.109" "1.145" "1.042" "1368.7" "1341.0" "1432.6" "1337.4" "1451.7" "1333.3" "1475.9" "1518.0" "1567.0" "1426.6" "" "" "" "" "" "" "" "" "" "" "1282.4" "1109.7" "1330.0" "1033.8" "1237.4" "1273.9" "1348.5" "1347.8" "1567.0" "1373.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3533447776593040930" "False" "High" "IsMasterProtein" "P26599" "Polypyrimidine tract-binding protein 1 OS=Homo sapiens OX=9606 GN=PTBP1 PE=1 SV=2" "0.000" "False" "39.362" "23" "13" "38" "10" "557" "59.6" "9.16" "108.89" "13" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "5725" "ENSG00000011304" "PTBP1" "hsa:5725; P26599; Q9BUQ0" "mir-124 predicted interactions with cell cycle and differentiation ; mRNA processing" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "5" "3" "0.966" "0.977" "0.969" "0.937" "0.959" "0.948" "0.928" "0.952" "0.970" "2414.8" "2333.7" "2358.8" "2340.1" "2263.2" "2316.8" "2289.2" "2241.5" "2298.6" "2341.6" "" "" "" "" "" "" "" "" "" "" "2262.7" "1931.1" "2189.9" "1809.0" "1929.1" "2213.4" "2091.7" "1990.2" "2298.6" "2254.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6452221919959736930" "False" "High" "IsMasterProtein" "O75122" "CLIP-associating protein 2 OS=Homo sapiens OX=9606 GN=CLASP2 PE=1 SV=3" "0.000" "False" "39.314" "10" "12" "17" "9" "1294" "141.0" "8.40" "52.80" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf12348, Pf21040" "23122" "ENSG00000163539" "CLASP2" "B2RTR1; F5H604; hsa:23122; O75122; Q7L8F6; Q8N6R6; Q9BQT3; Q9BQT4; Q9H7A3; Q9NSZ2" "7q11.23 copy number variation syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Role of ABL in ROBO-SLIT signaling" "8" "0" "1.029" "1.014" "1.002" "0.987" "0.980" "0.940" "0.923" "0.930" "1.008" "1656.7" "1705.0" "1679.5" "1660.1" "1634.4" "1624.3" "1557.8" "1529.3" "1540.9" "1670.0" "" "" "" "" "" "" "" "" "" "" "1552.3" "1410.9" "1559.2" "1283.3" "1393.1" "1551.9" "1423.4" "1357.9" "1540.9" "1608.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7630142415015692295" "False" "High" "IsMasterProtein" "P14314" "Glucosidase 2 subunit beta OS=Homo sapiens OX=9606 GN=PRKCSH PE=1 SV=2" "0.000" "False" "39.309" "24" "11" "28" "11" "528" "59.4" "4.41" "81.84" "11" "protein metabolism;other metabolic processes;developmental processes;signal transduction" "ER/Golgi;other cell component" "other molecular function" "Pf12999, Pf13015, Pf13202" "5589" "ENSG00000130175" "PRKCSH" "A8K318; hsa:5589; P14314; Q96BU9; Q96D06; Q9P0W9" "" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Advanced glycosylation endproduct receptor signaling; Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "7" "0" "1.024" "0.949" "0.953" "1.002" "0.978" "0.942" "1.014" "0.971" "0.983" "2945.4" "3014.8" "2795.6" "2807.2" "2951.7" "2881.3" "2773.6" "2987.2" "2860.5" "2894.3" "" "" "" "" "" "" "" "" "" "" "2759.8" "2494.7" "2595.3" "2170.1" "2516.0" "2752.8" "2534.4" "2652.4" "2860.5" "2786.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5539470002617871814" "False" "High" "IsMasterProtein" "Q9P2R7" "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLA2 PE=1 SV=3" "0.000" "False" "39.299" "25" "12" "17" "12" "463" "50.3" "7.42" "49.16" "12" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00549, Pf08442" "8803" "ENSG00000136143" "SUCLA2" "B2RDE7; hsa:8803; O95194; Q5T9Q4; Q5T9Q6; Q9NV21; Q9NVP7; Q9P2R7" "" "Citric acid cycle (TCA cycle)" "1" "0" "0.958" "1.037" "0.970" "1.011" "1.016" "0.978" "1.002" "0.994" "1.031" "1033.4" "990.1" "1072.1" "1002.3" "1044.6" "1049.8" "1010.2" "1035.0" "1027.7" "1065.3" "" "" "" "" "" "" "" "" "" "" "968.3" "819.3" "995.3" "774.8" "890.4" "1003.0" "923.1" "919.0" "1027.7" "1025.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5100342078982033337" "False" "High" "IsMasterProtein" "Q8N684" "Cleavage and polyadenylation specificity factor subunit 7 OS=Homo sapiens OX=9606 GN=CPSF7 PE=1 SV=1" "0.000" "False" "39.263" "28" "13" "21" "13" "471" "52.0" "8.00" "64.24" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "79869" "ENSG00000149532" "CPSF7" "B3KU04; C9K0Q4; hsa:79869; Q7Z3H9; Q8N684; Q9H025; Q9H9V1" "" "RHOBTB1 GTPase cycle; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.078" "1.005" "1.016" "1.109" "1.126" "1.110" "1.169" "1.202" "1.090" "1722.6" "1857.3" "1730.7" "1750.1" "1911.1" "1940.4" "1911.6" "2013.9" "2070.3" "1878.2" "" "" "" "" "" "" "" "" "" "" "1614.1" "1536.9" "1606.7" "1352.9" "1628.9" "1853.9" "1746.7" "1788.1" "2070.3" "1808.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6787199481091963945" "False" "High" "IsMasterProtein" "P04053" "DNA nucleotidylexotransferase OS=Homo sapiens OX=9606 GN=DNTT PE=1 SV=3" "0.000" "False" "39.211" "26" "14" "19" "14" "509" "58.5" "8.43" "50.76" "14" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf01909, Pf10391, Pf14716, Pf14791" "1791" "ENSG00000107447" "DNTT" "hsa:1791; P04053; Q53FH1; Q5W103; Q96E50" "" "" "0" "0" "0.960" "1.016" "0.995" "1.003" "1.016" "0.950" "0.954" "0.959" "1.026" "1701.9" "1633.6" "1729.4" "1693.1" "1706.5" "1729.0" "1616.7" "1623.4" "1632.7" "1746.5" "" "" "" "" "" "" "" "" "" "" "1594.7" "1351.8" "1605.5" "1308.9" "1454.6" "1651.9" "1477.3" "1441.4" "1632.7" "1681.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3366486650245995426" "False" "High" "IsMasterProtein" "P10515" "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLAT PE=1 SV=3" "0.000" "False" "39.206" "21" "12" "18" "12" "647" "69.0" "7.84" "55.05" "12" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00198, Pf00364, Pf02817" "1737" "ENSG00000150768" "DLAT" "hsa:1737; P10515; Q16783; Q53EP3" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "8" "0" "0.968" "1.030" "1.016" "1.006" "1.007" "1.011" "1.006" "0.969" "0.984" "1775.4" "1719.5" "1828.5" "1803.7" "1785.9" "1788.1" "1795.2" "1785.7" "1720.2" "1747.6" "" "" "" "" "" "" "" "" "" "" "1663.6" "1422.9" "1697.5" "1394.3" "1522.3" "1708.4" "1640.3" "1585.5" "1720.2" "1682.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-775611795353196892" "False" "High" "IsMasterProtein" "Q86XI2" "Condensin-2 complex subunit G2 OS=Homo sapiens OX=9606 GN=NCAPG2 PE=1 SV=1" "0.000" "False" "39.206" "12" "12" "14" "12" "1143" "130.9" "6.87" "43.05" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12422" "54892" "ENSG00000146918" "NCAPG2" "A4D228; hsa:54892; Q7Z3J9; Q86XI2; Q8WUG8; Q9BRX6; Q9H8S2; Q9H9K6" "Mesodermal commitment pathway" "Condensation of Prophase Chromosomes" "2" "0" "1.017" "1.007" "1.025" "1.010" "1.038" "0.949" "0.961" "1.046" "1.030" "1024.0" "1041.2" "1031.2" "1049.8" "1034.0" "1063.3" "971.3" "983.8" "1071.1" "1054.3" "" "" "" "" "" "" "" "" "" "" "959.5" "861.6" "957.3" "811.6" "881.3" "1015.9" "887.5" "873.5" "1071.1" "1015.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1351774447437735542" "False" "High" "IsMasterProtein" "Q9NQW7" "Xaa-Pro aminopeptidase 1 OS=Homo sapiens OX=9606 GN=XPNPEP1 PE=1 SV=3" "0.000" "False" "39.171" "21" "14" "23" "13" "623" "69.9" "5.67" "64.49" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00557, Pf01321, Pf16188, Pf16189" "7511" "ENSG00000108039" "XPNPEP1" "A8K071; G5E9Y2; G8JLB2; hsa:7511; O15250; Q53EX6; Q8N3Q0; Q96D23; Q9NQW7" "" "" "0" "0" "0.924" "0.962" "0.962" "0.942" "0.929" "0.931" "0.924" "0.912" "0.941" "2078.7" "1921.3" "1999.8" "1999.3" "1957.3" "1931.4" "1935.6" "1921.6" "1895.1" "1955.5" "" "" "" "" "" "" "" "" "" "" "1947.8" "1589.8" "1856.5" "1545.6" "1668.4" "1845.3" "1768.7" "1706.2" "1895.1" "1882.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4754969911618934256" "False" "High" "IsMasterProtein" "Q5H9R7" "Serine/threonine-protein phosphatase 6 regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PPP6R3 PE=1 SV=2" "0.000" "False" "39.141" "18" "13" "15" "13" "873" "97.6" "4.60" "46.38" "13" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf04499" "55291" "ENSG00000110075" "PPP6R3" "hsa:55291; Q3B7I1; Q3I4Y0; Q3KR35; Q5H9R7; Q68CR3; Q7L4R8; Q8N3B2; Q96MB2; Q9H2K5; Q9H2K6; Q9HCL4; Q9NUY3" "" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "2" "0" "1.048" "0.955" "1.079" "1.002" "0.998" "0.948" "0.961" "0.968" "0.991" "1318.4" "1381.6" "1258.9" "1422.3" "1320.7" "1315.2" "1250.2" "1266.7" "1276.6" "1307.1" "" "" "" "" "" "" "" "" "" "" "1235.4" "1143.2" "1168.7" "1099.5" "1125.8" "1256.6" "1142.3" "1124.7" "1276.6" "1258.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6101173507286650100" "False" "High" "IsMasterProtein" "O43852" "Calumenin OS=Homo sapiens OX=9606 GN=CALU PE=1 SV=2" "0.000" "False" "39.140" "35" "9" "17" "9" "315" "37.1" "4.64" "55.94" "9" "" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf13202" "813" "ENSG00000128595" "CALU" "B3KPG9; D6QS48; D6QS49; D6QS50; D6QS51; D6QS52; D6QS53; D6QS54; D6QS55; D6QS56; D6QS57; D6QS58; D6QS59; F5H1Q9; F5H879; hsa:813; O43852; O60456; Q6FHB9; Q96RL3; Q9NR43" "NOTCH1 regulation of endothelial cell calcification; VEGFA-VEGFR2 signaling" "Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "5" "0" "1.010" "1.008" "0.980" "1.030" "0.986" "0.939" "1.001" "1.001" "1.002" "1368.8" "1382.7" "1380.0" "1341.6" "1410.1" "1350.0" "1285.6" "1370.5" "1369.6" "1371.0" "" "" "" "" "" "" "" "" "" "" "1282.6" "1144.2" "1281.1" "1037.1" "1201.9" "1289.8" "1174.7" "1216.8" "1369.6" "1320.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7172207260123364247" "False" "High" "IsMasterProtein" "P11172" "Uridine 5'-monophosphate synthase OS=Homo sapiens OX=9606 GN=UMPS PE=1 SV=1" "0.000" "False" "39.118" "26" "14" "22" "14" "480" "52.2" "7.24" "72.36" "14" "other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00156, Pf00215" "7372" "ENSG00000114491" "UMPS" "B5LY68; B5LY72; hsa:7372; O00758; O00759; O00760; P11172; Q16862; Q9H3Q2; Q9UG49" "Fluoropyrimidine activity; Pyrimidine metabolism" "Pyrimidine biosynthesis" "3" "0" "0.916" "0.937" "0.925" "0.955" "0.976" "0.938" "0.944" "0.933" "0.949" "1931.4" "1769.2" "1809.8" "1785.9" "1844.0" "1885.3" "1811.4" "1824.1" "1801.2" "1832.7" "" "" "" "" "" "" "" "" "" "" "1809.7" "1464.0" "1680.1" "1380.5" "1571.8" "1801.2" "1655.1" "1619.6" "1801.2" "1764.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1398033593130895886" "False" "High" "IsMasterProtein" "O43264" "Centromere/kinetochore protein zw10 homolog OS=Homo sapiens OX=9606 GN=ZW10 PE=1 SV=3" "0.000" "False" "39.073" "15" "12" "13" "12" "779" "88.8" "6.27" "39.63" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf06248, Pf20665, Pf20666" "9183" "ENSG00000086827" "ZW10" "A1A528; hsa:9183; O43264" "" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "0.977" "1.053" "1.101" "1.001" "1.063" "1.010" "1.040" "0.963" "0.991" "917.2" "896.1" "966.3" "1009.8" "918.5" "975.1" "926.2" "954.1" "883.6" "908.8" "" "" "" "" "" "" "" "" "" "" "859.5" "741.5" "897.1" "780.7" "782.9" "931.7" "846.3" "847.1" "883.6" "875.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6100436114582122401" "False" "High" "IsMasterProtein" "Q93034" "Cullin-5 OS=Homo sapiens OX=9606 GN=CUL5 PE=1 SV=4" "0.000" "False" "39.059" "17" "15" "19" "15" "780" "90.9" "7.94" "57.73" "15" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;signal transduction" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf00888, Pf10557" "8065" "ENSG00000166266" "CUL5" "A8K960; O14766; Q93034; Q9BZC6" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Dual hijack model of Vif in HIV infection; Modulators of TCR signaling and T cell activation; 10q11.21q11.23 copy number variation syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling; Downregulation of ERBB2 signaling; Evasion by RSV of host interferon responses" "10" "0" "0.960" "0.952" "0.999" "0.983" "0.970" "0.975" "0.975" "0.931" "0.959" "2577.5" "2474.5" "2454.8" "2574.2" "2533.1" "2499.3" "2513.7" "2512.7" "2400.8" "2471.4" "" "" "" "" "" "" "" "" "" "" "2415.1" "2047.6" "2279.0" "1990.0" "2159.1" "2387.8" "2296.9" "2231.0" "2400.8" "2379.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3530888468156294697" "False" "High" "IsMasterProtein" "O00541" "Pescadillo homolog OS=Homo sapiens OX=9606 GN=PES1 PE=1 SV=1" "0.000" "False" "39.033" "23" "12" "14" "12" "588" "68.0" "7.33" "47.26" "12" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06732, Pf16589" "23481" "ENSG00000100029" "PES1" "hsa:23481; O00541; Q6IC29" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.029" "1.047" "1.177" "1.133" "1.175" "1.121" "1.069" "1.111" "1.107" "840.0" "864.1" "879.5" "988.7" "952.0" "987.1" "941.5" "898.3" "933.3" "929.6" "" "" "" "" "" "" "" "" "" "" "787.1" "715.0" "816.5" "764.3" "811.4" "943.1" "860.3" "797.6" "933.3" "895.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1938619972574952291" "False" "High" "IsMasterProtein" "Q9ULW0" "Targeting protein for Xklp2 OS=Homo sapiens OX=9606 GN=TPX2 PE=1 SV=2" "0.000" "False" "39.032" "17" "14" "20" "14" "747" "85.6" "9.23" "53.22" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06886, Pf09041, Pf12214" "22974" "ENSG00000088325" "TPX2" "hsa:22974; Q96RR5; Q9H1R4; Q9NRA3; Q9UFN9; Q9UL00; Q9ULW0; Q9Y2M1" "Gastric cancer network 1" "Regulation of TP53 Activity through Phosphorylation; AURKA Activation by TPX2" "3" "0" "0.988" "1.009" "0.973" "1.041" "0.989" "0.968" "0.988" "0.971" "0.992" "2003.6" "1979.3" "2022.2" "1949.2" "2084.8" "1980.7" "1939.8" "1979.7" "1944.6" "1987.7" "" "" "" "" "" "" "" "" "" "" "1877.3" "1637.8" "1877.4" "1506.9" "1777.0" "1892.3" "1772.5" "1757.8" "1944.6" "1913.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6575553270224251994" "False" "High" "IsMasterProtein" "P55010" "Eukaryotic translation initiation factor 5 OS=Homo sapiens OX=9606 GN=EIF5 PE=1 SV=2" "0.000" "False" "39.027" "31" "14" "19" "13" "431" "49.2" "5.58" "51.36" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01873, Pf02020" "1983" "ENSG00000100664" "EIF5" "hsa:1983; P55010; Q53XB3; Q9H5N2; Q9UG48" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "4" "1" "0.977" "1.045" "0.997" "1.026" "1.065" "0.992" "1.031" "1.013" "1.027" "2315.4" "2261.8" "2420.1" "2308.7" "2376.7" "2465.8" "2297.1" "2388.3" "2346.1" "2378.5" "" "" "" "" "" "" "" "" "" "" "2169.6" "1871.6" "2246.7" "1784.7" "2025.9" "2355.9" "2099.0" "2120.6" "2346.1" "2290.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-938207872866175487" "False" "High" "IsMasterProtein" "Q00534" "Cyclin-dependent kinase 6 OS=Homo sapiens OX=9606 GN=CDK6 PE=1 SV=1" "0.000" "False" "38.981" "41" "12" "18" "11" "326" "36.9" "6.46" "60.69" "12" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1021" "ENSG00000105810" "CDK6" "A4D1G0; hsa:1021; Q00534" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Metastatic brain tumor; Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Wnt signaling pathway; PI3K-Akt signaling pathway; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Influence of laminopathies on Wnt signaling; DYRK1A involvement regarding cell proliferation in brain development; DNA damage response" "Oxidative Stress Induced Senescence; Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Senescence-Associated Secretory Phenotype (SASP); Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Drug-mediated inhibition of CDK4/CDK6 activity; Regulation of RUNX1 Expression and Activity" "30" "1" "0.928" "0.989" "0.931" "0.928" "0.943" "0.847" "0.860" "0.868" "0.946" "2898.9" "2690.9" "2868.3" "2698.2" "2690.3" "2733.4" "2456.3" "2493.9" "2515.9" "2741.6" "" "" "" "" "" "" "" "" "" "" "2716.2" "2226.7" "2662.8" "2085.9" "2293.1" "2611.5" "2244.4" "2214.4" "2515.9" "2639.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-199396300438152648" "False" "High" "IsMasterProtein" "P25788" "Proteasome subunit alpha type-3 OS=Homo sapiens OX=9606 GN=PSMA3 PE=1 SV=2" "0.000" "False" "38.958" "37" "11" "21" "11" "255" "28.4" "5.33" "70.28" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf10584" "5684" "ENSG00000100567" "PSMA3" "B2RCK6; hsa:5684; P25788; Q86U83; Q8N1D8; Q9BS70" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Interleukin-1 signaling; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; UCH proteinases; Regulation of RUNX3 expression and activity; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.985" "0.967" "0.918" "0.925" "1.017" "0.890" "0.943" "1.013" "0.951" "3532.1" "3479.9" "3416.4" "3243.3" "3266.0" "3591.6" "3143.9" "3332.1" "3577.0" "3359.5" "" "" "" "" "" "" "" "" "" "" "3309.6" "2879.6" "3171.6" "2507.2" "2783.8" "3431.5" "2872.7" "2958.5" "3577.0" "3234.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-792882720935006206" "False" "High" "IsMasterProtein" "Q9HAV4" "Exportin-5 OS=Homo sapiens OX=9606 GN=XPO5 PE=1 SV=1" "0.000" "False" "38.948" "12" "15" "20" "15" "1204" "136.2" "5.80" "51.38" "15" "RNA metabolism OR transcription;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf19273" "57510" "ENSG00000124571" "XPO5" "hsa:57510; Q5JTE6; Q96G48; Q96HN3; Q9BWM6; Q9BZV5; Q9H9M4; Q9HAV4; Q9NT89; Q9NW39; Q9ULC9" "miRNA biogenesis; exRNA mechanism of action and biogenesis; Primary ovarian insufficiency" "MicroRNA (miRNA) biogenesis" "4" "0" "0.955" "1.004" "1.021" "1.013" "0.948" "0.946" "0.941" "0.975" "0.969" "2253.8" "2151.3" "2262.1" "2301.0" "2283.8" "2137.4" "2132.1" "2119.7" "2197.0" "2183.3" "" "" "" "" "" "" "" "" "" "" "2111.8" "1780.2" "2100.0" "1778.8" "1946.7" "2042.1" "1948.2" "1882.1" "2197.0" "2102.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3933333122988886366" "False" "High" "IsMasterProtein" "Q6ZNJ1" "Neurobeachin-like protein 2 OS=Homo sapiens OX=9606 GN=NBEAL2 PE=1 SV=2" "0.000" "False" "38.930" "5" "15" "17" "15" "2754" "302.3" "6.38" "49.50" "15" "other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "other molecular function" "Pf02138, Pf14844, Pf15787, Pf16057, Pf20425, Pf20426" "23218" "ENSG00000160796" "NBEAL2" "hsa:23218; O60288; Q6P994; Q6UX91; Q6ZNJ1; Q8NAC9" "" "Neutrophil degranulation" "1" "0" "1.008" "1.026" "1.091" "1.086" "1.044" "1.064" "1.010" "0.992" "1.023" "1374.2" "1385.1" "1409.5" "1499.1" "1492.5" "1434.6" "1462.2" "1388.5" "1362.9" "1405.5" "" "" "" "" "" "" "" "" "" "" "1287.7" "1146.2" "1308.5" "1158.9" "1272.2" "1370.7" "1336.1" "1232.9" "1362.9" "1353.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "370565265455321105" "False" "High" "IsMasterProtein" "Q8IU81" "Interferon regulatory factor 2-binding protein 1 OS=Homo sapiens OX=9606 GN=IRF2BP1 PE=1 SV=1" "0.000" "False" "38.885" "25" "14" "17" "14" "584" "61.6" "8.18" "51.29" "14" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11261" "26145" "ENSG00000170604" "IRF2BP1" "Q53EL7; Q6DC95; Q8IU81; Q9BRZ9; Q9Y4P4" "" "" "0" "0" "1.027" "1.001" "1.077" "1.082" "1.055" "1.067" "1.013" "1.011" "1.037" "954.0" "979.9" "954.8" "1027.1" "1032.6" "1006.0" "1017.5" "966.1" "964.5" "988.8" "" "" "" "" "" "" "" "" "" "" "893.9" "810.9" "886.4" "794.0" "880.1" "961.1" "929.7" "857.8" "964.5" "952.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-466153880284673871" "False" "High" "IsMasterProtein" "Q12873" "Chromodomain-helicase-DNA-binding protein 3 OS=Homo sapiens OX=9606 GN=CHD3 PE=1 SV=3" "0.000" "False" "38.875" "8" "13" "18" "6" "2000" "226.5" "7.30" "48.63" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf00628, Pf06461, Pf06465, Pf08073, Pf08074" "1107" "ENSG00000170004" "CHD3" "D3DTQ9; E9PG89; hsa:1107; Q12873; Q9Y4I0" "Effect of progerin on genes involved in progeria" "HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Potential therapeutics for SARS; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; Regulation of TP53 Activity through Acetylation" "8" "0" "0.917" "1.040" "1.101" "0.995" "0.965" "1.013" "0.947" "0.875" "0.939" "587.3" "538.4" "610.6" "646.8" "584.4" "566.7" "594.8" "556.0" "513.7" "551.6" "" "" "" "" "" "" "" "" "" "" "550.3" "445.5" "566.9" "500.0" "498.2" "541.4" "543.5" "493.7" "513.7" "531.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6719730535871434509" "False" "High" "IsMasterProtein" "P16989" "Y-box-binding protein 3 OS=Homo sapiens OX=9606 GN=YBX3 PE=1 SV=4" "0.000" "False" "38.854" "36" "10" "17" "7" "372" "40.1" "9.77" "54.61" "10" "stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00313" "8531" "ENSG00000060138" "YBX3" "B2RBW6; hsa:8531; P16989; Q14121; Q969N6; Q96B76" "RalA downstream regulated genes; Apoptosis-related network due to altered Notch3 in ovarian cancer" "" "2" "0" "0.978" "0.977" "0.985" "0.949" "0.921" "0.921" "0.914" "0.899" "0.920" "703.9" "688.8" "687.5" "693.1" "668.1" "648.1" "648.3" "643.3" "632.5" "647.9" "" "" "" "" "" "" "" "" "" "" "659.6" "569.9" "638.2" "535.8" "569.5" "619.2" "592.4" "571.1" "632.5" "623.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6888826320597161834" "False" "High" "IsMasterProtein" "Q16630" "Cleavage and polyadenylation specificity factor subunit 6 OS=Homo sapiens OX=9606 GN=CPSF6 PE=1 SV=2" "0.000" "False" "38.839" "22" "11" "24" "11" "551" "59.2" "7.15" "70.22" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00076" "11052" "ENSG00000111605" "CPSF6" "A8K7K9; hsa:11052; Q16630; Q53ES1; Q9BSJ7; Q9BW18" "" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "2" "0" "1.034" "1.050" "1.089" "1.138" "1.171" "1.082" "1.198" "1.162" "1.098" "1457.1" "1506.8" "1529.4" "1586.6" "1657.8" "1705.5" "1576.0" "1745.3" "1692.6" "1599.6" "" "" "" "" "" "" "" "" "" "" "1365.3" "1246.8" "1419.8" "1226.5" "1413.0" "1629.4" "1440.1" "1549.6" "1692.6" "1540.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6124389197736880790" "False" "High" "IsMasterProtein" "P40925" "Malate dehydrogenase, cytoplasmic OS=Homo sapiens OX=9606 GN=MDH1 PE=1 SV=4" "0.000" "False" "38.829" "31" "11" "33" "11" "334" "36.4" "7.36" "86.17" "11" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00056, Pf02866" "4190" "ENSG00000014641" "MDH1" "B2R5V5; B4DUN2; B7Z3I7; F5H098; hsa:4190; P40925; Q6I9V0" "Sterol regulatory element-binding proteins (SREBP) signaling; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Clear cell renal cell carcinoma pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; TCA cycle in senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; HDAC6 interactions in the central nervous system" "Gluconeogenesis" "10" "0" "0.902" "0.949" "0.907" "0.873" "0.902" "0.902" "0.889" "0.917" "0.879" "5664.3" "5110.6" "5373.5" "5135.2" "4946.9" "5110.6" "5108.0" "5033.8" "5195.7" "4978.2" "" "" "" "" "" "" "" "" "" "" "5307.4" "4229.0" "4988.6" "3969.7" "4216.6" "4882.7" "4667.3" "4469.5" "5195.7" "4793.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3364177795992672609" "False" "High" "IsMasterProtein" "P42765" "3-ketoacyl-CoA thiolase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAA2 PE=1 SV=2" "0.000" "False" "38.817" "36" "11" "16" "11" "397" "41.9" "8.09" "55.13" "11" "cell organization and biogenesis;other metabolic processes;stress response;transport" "mitochondrion" "other molecular function" "Pf00108, Pf02803" "10449" "ENSG00000167315" "ACAA2" "hsa:10449; P42765; Q9BUT6" "Fatty acid biosynthesis" "Mitochondrial Fatty Acid Beta-Oxidation" "2" "0" "0.965" "0.994" "0.941" "0.975" "0.983" "0.885" "0.957" "0.931" "0.943" "1497.8" "1444.8" "1488.5" "1408.8" "1460.1" "1472.9" "1326.1" "1433.7" "1394.7" "1412.1" "" "" "" "" "" "" "" "" "" "" "1403.4" "1195.6" "1381.9" "1089.0" "1244.6" "1407.2" "1211.7" "1272.9" "1394.7" "1359.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1645614495321622240" "False" "High" "IsMasterProtein" "P57678" "Gem-associated protein 4 OS=Homo sapiens OX=9606 GN=GEMIN4 PE=1 SV=2" "0.000" "False" "38.795" "11" "12" "16" "12" "1058" "120.0" "6.04" "52.45" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "" "50628" "ENSG00000179409" "GEMIN4" "hsa:50628; P57678; Q9NZS7; Q9UG32; Q9Y4Q2" "" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "2" "0" "1.073" "1.084" "1.101" "1.101" "1.078" "1.007" "0.917" "0.999" "1.047" "901.7" "967.7" "977.1" "993.0" "992.9" "971.6" "907.9" "826.8" "900.8" "944.0" "" "" "" "" "" "" "" "" "" "" "844.9" "800.8" "907.1" "767.7" "846.4" "928.3" "829.5" "734.1" "900.8" "908.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4461868117343589472" "False" "High" "IsMasterProtein" "Q66K14" "TBC1 domain family member 9B OS=Homo sapiens OX=9606 GN=TBC1D9B PE=1 SV=3" "0.000" "False" "38.785" "10" "13" "16" "13" "1250" "140.4" "5.25" "53.02" "13" "" "other membranes" "enzyme regulator activity;other molecular function" "Pf00566, Pf02893" "23061" "ENSG00000197226; ENSG00000284400" "TBC1D9B" "D3DWQ5; D3DWQ6; hsa:23061; O75163; Q53EY0; Q66K14; Q6MZI2; Q96H49" "" "" "0" "0" "1.013" "1.027" "0.985" "1.050" "1.063" "1.028" "0.993" "1.008" "1.038" "1271.2" "1287.3" "1306.0" "1252.6" "1335.0" "1351.8" "1306.6" "1262.4" "1281.6" "1319.9" "" "" "" "" "" "" "" "" "" "" "1191.1" "1065.2" "1212.5" "968.3" "1137.9" "1291.5" "1193.9" "1120.9" "1281.6" "1270.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8648350258145669710" "False" "High" "IsMasterProtein" "Q15717" "ELAV-like protein 1 OS=Homo sapiens OX=9606 GN=ELAVL1 PE=1 SV=2" "0.000" "False" "38.760" "34" "10" "24" "10" "326" "36.1" "9.17" "77.33" "10" "cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "1994" "ENSG00000066044" "ELAVL1" "B4DVB8; hsa:1994; Q15717; Q53XN6; Q9BTT1" "AMP-activated protein kinase signaling; Endoderm differentiation; Pre-implantation embryo; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Gastrin signaling pathway; IL-18 signaling pathway; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; 1p36 copy number variation syndrome" "HuR (ELAVL1) binds and stabilizes mRNA" "10" "0" "0.940" "0.959" "0.986" "0.948" "0.961" "0.936" "0.912" "0.924" "0.941" "2566.0" "2412.1" "2462.0" "2529.7" "2433.1" "2467.0" "2402.8" "2339.5" "2371.8" "2415.4" "" "" "" "" "" "" "" "" "" "" "2404.3" "1996.0" "2285.7" "1955.6" "2073.9" "2357.0" "2195.6" "2077.2" "2371.8" "2325.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8900163226744829744" "False" "High" "IsMasterProtein" "Q99590" "Protein SCAF11 OS=Homo sapiens OX=9606 GN=SCAF11 PE=1 SV=2" "0.000" "False" "38.726" "9" "12" "16" "12" "1463" "164.6" "8.41" "51.33" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf13639" "9169" "ENSG00000139218" "SCAF11" "A6NEU9; A6NLW5; hsa:9169; Q8IW59; Q99590" "Apoptosis" "" "1" "0" "1.058" "1.057" "1.085" "1.104" "1.078" "1.215" "1.268" "1.224" "1.166" "1376.2" "1455.3" "1454.5" "1493.8" "1518.8" "1484.2" "1672.0" "1744.3" "1683.8" "1604.2" "" "" "" "" "" "" "" "" "" "" "1289.5" "1204.3" "1350.3" "1154.8" "1294.6" "1418.0" "1527.7" "1548.8" "1683.8" "1544.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1166927996766443346" "False" "High" "IsMasterProtein" "P28482" "Mitogen-activated protein kinase 1 OS=Homo sapiens OX=9606 GN=MAPK1 PE=1 SV=3" "0.000" "False" "38.697" "35" "13" "19" "10" "360" "41.4" "6.98" "53.80" "13" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "5594" "ENSG00000100030" "MAPK1" "A8CZ64; hsa:5594; P28482" "IL-5 signaling pathway; Osteopontin signaling; Physiological and pathological hypertrophy of the heart; Angiogenesis; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; Heart development; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Endothelin pathways; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; PDGF pathway; Aryl hydrocarbon receptor pathway; S1P receptor signal transduction; Ebstein-Barr virus LMP1 signaling; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; TCA cycle nutrient use and invasiveness of ovarian cancer; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; IL6 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; ERK pathway in Huntington's disease; Toll-like receptor signaling related to MyD88; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; Prion disease pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Neovascularization processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Bile acids synthesis and enterohepatic circulation ; LTF danger signal response pathway; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Regulatory circuits of the STAT3 signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; Kisspeptin/kisspeptin receptor system in the ovary; MAP3K1 role in promoting and blocking gonadal determination; CAMKK2 pathway; Disruption of postsynaptic signaling by CNV; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; RAS and bradykinin pathways in COVID-19; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Sphingolipid metabolism in senescence; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; 2q11.2 copy number variation syndrome; 2q13 copy number variation syndrome; Hippocampal synaptogenesis and neurogenesis; Comprehensive IL-17A signaling; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; Female steroid hormones in cardiomyocyte energy metabolism; Cardiomyocyte signaling pathways converging on titin; 8p23.1 copy number variation syndrome; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; Osteoarthritic chondrocyte hypertrophy; NPHP1 deletion syndrome; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Vitamin A and carotenoid metabolism; Toll-like receptor signaling pathway" "Recycling pathway of L1; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCGR3A-mediated phagocytosis; NPAS4 regulates expression of target genes; RHO GTPases Activate WASPs and WAVEs; Regulation of HSF1-mediated heat shock response; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Signaling by NODAL; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Interferon gamma signaling; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Growth hormone receptor signaling; Regulation of the apoptosome activity; Signal transduction by L1; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; RUNX2 regulates osteoblast differentiation; RSK activation; Estrogen-stimulated signaling through PRKCZ; Spry regulation of FGF signaling; Suppression of apoptosis; MAPK1 (ERK2) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; IFNG signaling activates MAPKs; Golgi Cisternae Pericentriolar Stack Reorganization; Signaling by Activin; Activation of the AP-1 family of transcription factors; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Signal attenuation; Gastrin-CREB signalling pathway via PKC and MAPK; ESR-mediated signaling; Negative feedback regulation of MAPK pathway; Advanced glycosylation endproduct receptor signaling; RHO GTPases Activate NADPH Oxidases; Nuclear events stimulated by ALK signaling in cancer; ERKs are inactivated; Signaling by MAP2K mutants; phospho-PLA2 pathway; Signaling by MAPK mutants" "208" "2" "0.936" "0.956" "0.994" "0.949" "0.969" "0.935" "0.953" "0.906" "0.938" "2607.9" "2440.2" "2494.2" "2591.0" "2475.7" "2526.1" "2438.5" "2486.4" "2363.3" "2447.5" "" "" "" "" "" "" "" "" "" "" "2443.6" "2019.2" "2315.6" "2003.0" "2110.3" "2413.4" "2228.2" "2207.7" "2363.3" "2356.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2107690767117566608" "False" "High" "IsMasterProtein" "P04150" "Glucocorticoid receptor OS=Homo sapiens OX=9606 GN=NR3C1 PE=1 SV=1" "0.000" "False" "38.687" "18" "12" "14" "12" "777" "85.6" "6.38" "53.74" "12" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105, Pf02155" "2908" "ENSG00000113580" "NR3C1" "A0ZXF9; B0LPG8; D3DQF4; F5ATB7; hsa:2908; P04150; P04151; Q53EP5; Q6N0A4" "Nuclear receptors; Adipogenesis; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Endoderm differentiation; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; White fat cell differentiation; Vitamin D in inflammatory diseases; 16p11.2 proximal deletion syndrome; HDAC6 interactions in the central nervous system; Sudden infant death syndrome (SIDS) susceptibility pathways; Serotonin receptor 4/6/7 and NR3C signaling" "Potential therapeutics for SARS; Regulation of RUNX2 expression and activity; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Circadian Clock; SUMOylation of intracellular receptors; PTK6 Expression; Regulation of NPAS4 gene transcription" "21" "0" "1.019" "0.970" "0.890" "0.932" "0.916" "0.797" "0.833" "0.851" "0.936" "1911.4" "1946.8" "1853.5" "1700.7" "1782.3" "1750.3" "1523.3" "1591.7" "1626.0" "1788.3" "" "" "" "" "" "" "" "" "" "" "1791.0" "1610.9" "1720.7" "1314.8" "1519.2" "1672.3" "1391.9" "1413.2" "1626.0" "1721.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4845069297566421061" "False" "High" "IsMasterProtein" "P35221" "Catenin alpha-1 OS=Homo sapiens OX=9606 GN=CTNNA1 PE=1 SV=1" "0.000" "False" "38.677" "15" "12" "14" "12" "906" "100.0" "6.29" "47.28" "12" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01044" "1495" "ENSG00000044115" "CTNNA1" "hsa:1495; P35221; Q12795; Q8N1C0" "Arrhythmogenic right ventricular cardiomyopathy; Apoptosis-related network due to altered Notch3 in ovarian cancer; VEGFA-VEGFR2 signaling; White fat cell differentiation; Endometrial cancer; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Pleural mesothelioma" "RHO GTPases activate IQGAPs; Myogenesis; VEGFR2 mediated vascular permeability; Adherens junctions interactions; Regulation of CDH11 function; Regulation of CDH19 Expression and Function; CDH11 homotypic and heterotypic interactions" "15" "0" "0.987" "1.029" "0.986" "1.003" "1.017" "0.962" "0.953" "0.972" "1.001" "1763.7" "1740.4" "1814.7" "1739.8" "1769.7" "1793.2" "1696.5" "1681.6" "1714.8" "1766.3" "" "" "" "" "" "" "" "" "" "" "1652.6" "1440.2" "1684.7" "1344.9" "1508.4" "1713.2" "1550.2" "1493.1" "1714.8" "1700.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6789229082663828317" "False" "High" "IsMasterProtein" "Q6ZUJ8" "Phosphoinositide 3-kinase adapter protein 1 OS=Homo sapiens OX=9606 GN=PIK3AP1 PE=1 SV=2" "0.000" "False" "38.546" "19" "12" "19" "12" "805" "90.3" "5.40" "52.66" "12" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "signal transduction activity or receptor binding;other molecular function" "Pf14545, Pf18567" "118788" "ENSG00000155629" "PIK3AP1" "hsa:118788; Q5TB56; Q5VXJ9; Q6ZUJ8; Q8N6J6; Q8NAC8" "B cell receptor signaling pathway; PI3K-Akt signaling pathway" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer" "6" "0" "0.986" "0.971" "0.979" "1.012" "1.004" "0.937" "0.911" "0.908" "0.981" "1412.0" "1392.7" "1370.6" "1382.9" "1428.7" "1417.6" "1323.6" "1286.2" "1282.4" "1385.2" "" "" "" "" "" "" "" "" "" "" "1323.0" "1152.4" "1272.4" "1069.0" "1217.8" "1354.4" "1209.4" "1142.0" "1282.4" "1333.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6470269132294442760" "False" "High" "IsMasterProtein" "Q8WUM0" "Nuclear pore complex protein Nup133 OS=Homo sapiens OX=9606 GN=NUP133 PE=1 SV=2" "0.000" "False" "38.539" "12" "13" "13" "13" "1156" "128.9" "5.10" "40.34" "13" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03177" "55746" "ENSG00000069248" "NUP133" "B2RAZ8; hsa:55746; Q5T8N0; Q8WUM0; Q9H9W2; Q9NV71; Q9NVC4" "Ciliary landscape" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Transport of Mature mRNA derived from an Intron-Containing Transcript; Separation of Sister Chromatids; Regulation of HSF1-mediated heat shock response; snRNP Assembly; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "36" "0" "0.963" "0.946" "1.014" "1.000" "0.983" "0.985" "0.938" "0.905" "0.940" "1193.8" "1149.4" "1129.9" "1210.4" "1194.0" "1173.1" "1175.5" "1119.5" "1080.2" "1122.2" "" "" "" "" "" "" "" "" "" "" "1118.6" "951.2" "1049.0" "935.7" "1017.7" "1120.8" "1074.1" "994.0" "1080.2" "1080.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7405730642826192701" "False" "High" "IsMasterProtein" "P00390" "Glutathione reductase, mitochondrial OS=Homo sapiens OX=9606 GN=GSR PE=1 SV=2" "0.000" "False" "38.538" "25" "11" "19" "11" "522" "56.2" "8.50" "56.70" "11" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf00070, Pf02852" "2936" "ENSG00000104687" "GSR" "C8KIL8; C8KIL9; C8KIM0; D3DSV3; hsa:2936; P00390; Q7Z5C9; Q9NP63" "Glutathione metabolism; Selenium micronutrient network; Trans-sulfuration, one-carbon metabolism and related pathways; Nuclear receptors meta-pathway; NRF2 pathway; Amino acid metabolism; One-carbon metabolism and related pathways; Oxidative stress response; Vitamin D-sensitive calcium signaling in depression; Sulfation biotransformation reaction; Metapathway biotransformation Phase I and II" "" "11" "0" "0.983" "0.963" "1.025" "0.939" "1.072" "0.895" "0.993" "0.956" "0.960" "1416.7" "1393.3" "1364.9" "1452.7" "1330.7" "1518.3" "1268.4" "1406.8" "1353.8" "1359.4" "" "" "" "" "" "" "" "" "" "" "1327.5" "1152.9" "1267.2" "1123.0" "1134.3" "1450.6" "1159.0" "1249.1" "1353.8" "1309.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8471595991882746273" "False" "High" "IsMasterProtein" "P35612" "Beta-adducin OS=Homo sapiens OX=9606 GN=ADD2 PE=1 SV=3" "0.000" "False" "38.488" "21" "13" "15" "12" "726" "80.8" "5.92" "47.23" "13" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "119" "ENSG00000075340" "ADD2" "A8K4P2; B4DM17; D6W5G7; D6W5G8; hsa:119; P35612; Q13482; Q16412; Q59G82; Q5U5P4; Q6P0P2; Q6PGQ4; Q7Z688; Q7Z689; Q7Z690; Q7Z691" "" "Miscellaneous transport and binding events" "1" "1" "0.989" "1.013" "1.064" "1.018" "0.990" "0.987" "1.023" "0.929" "1.010" "2041.6" "2019.8" "2069.1" "2171.4" "2077.7" "2021.2" "2015.0" "2087.9" "1896.7" "2061.6" "" "" "" "" "" "" "" "" "" "" "1913.0" "1671.4" "1920.9" "1678.6" "1771.0" "1931.0" "1841.2" "1853.9" "1896.7" "1985.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1535897714363242613" "False" "High" "IsMasterProtein" "Q15019" "Septin-2 OS=Homo sapiens OX=9606 GN=SEPTIN2 PE=1 SV=1" "0.000" "False" "38.487" "37" "11" "19" "11" "361" "41.5" "6.60" "54.69" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00735" "4735" "ENSG00000168385" "SEPTIN2" "B4DGE8; hsa:4735; Q14132; Q15019; Q53QU3; Q8IUK9; Q96CB0" "2q37 copy number variation syndrome" "Anchoring of the basal body to the plasma membrane" "2" "0" "0.929" "0.975" "0.951" "0.925" "0.920" "0.931" "0.963" "0.881" "0.909" "1589.7" "1476.9" "1550.0" "1512.6" "1470.7" "1462.1" "1479.3" "1531.5" "1400.7" "1444.8" "" "" "" "" "" "" "" "" "" "" "1489.6" "1222.1" "1438.9" "1169.3" "1253.6" "1396.9" "1351.6" "1359.8" "1400.7" "1391.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5275540959932174837" "False" "High" "IsMasterProtein" "Q14847" "LIM and SH3 domain protein 1 OS=Homo sapiens OX=9606 GN=LASP1 PE=1 SV=2" "0.000" "False" "38.408" "44" "11" "18" "11" "261" "29.7" "7.05" "52.02" "11" "transport" "cytoskeleton;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00412, Pf00880, Pf14604" "3927" "ENSG00000002834" "LASP1" "B4DGQ0; hsa:3927; Q14847; Q96ED2; Q96IG0" "17q12 copy number variation syndrome" "" "1" "0" "1.091" "1.036" "0.970" "1.007" "0.911" "0.867" "0.934" "0.906" "0.941" "2143.8" "2338.6" "2219.9" "2080.2" "2158.2" "1953.1" "1858.7" "2003.1" "1941.4" "2017.1" "" "" "" "" "" "" "" "" "" "" "2008.7" "1935.1" "2060.9" "1608.1" "1839.6" "1866.0" "1698.3" "1778.6" "1941.4" "1942.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2566135857611723126" "False" "High" "IsMasterProtein" "P23743" "Diacylglycerol kinase alpha OS=Homo sapiens OX=9606 GN=DGKA PE=1 SV=3" "0.000" "False" "38.407" "20" "13" "16" "13" "735" "82.6" "6.73" "46.44" "13" "other metabolic processes;stress response;signal transduction" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf00130, Pf00609, Pf00781, Pf14513" "1606" "ENSG00000065357" "DGKA" "hsa:1606; O75481; O75482; O75483; O95217; P23743; Q3ZE25; Q8IZ56; Q8N5Q2" "Modulators of TCR signaling and T cell activation" "Effects of PIP2 hydrolysis" "2" "0" "0.994" "1.032" "1.022" "1.031" "1.010" "0.983" "1.013" "0.956" "1.003" "2393.3" "2379.1" "2471.1" "2445.5" "2467.0" "2417.2" "2352.3" "2425.3" "2287.9" "2401.6" "" "" "" "" "" "" "" "" "" "" "2242.5" "1968.7" "2294.1" "1890.5" "2102.8" "2309.4" "2149.4" "2153.4" "2287.9" "2312.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "714954485545523239" "False" "High" "IsMasterProtein" "P27986" "Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Homo sapiens OX=9606 GN=PIK3R1 PE=1 SV=2" "0.000" "False" "38.371" "17" "12" "14" "12" "724" "83.5" "6.16" "48.24" "12" "cell adhesion;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00620, Pf16454" "5295" "ENSG00000145675" "PIK3R1" "B3KT19; D3DWA0; E7EX19; hsa:5295; P27986; Q15747; Q4VBZ7; Q53EM6; Q8IXA2; Q8N1C5" "IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Apoptosis; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; PDGFR-beta pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Overview of interferons-mediated signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; IL-18 signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; Interferon type I signaling pathways; Notch signaling pathway; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; RHOC GTPase cycle; Downstream TCR signaling; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; G alpha (q) signalling events; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; RHOU GTPase cycle; Synthesis of PIPs at the plasma membrane; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; RAF/MAP kinase cascade; PI3K Cascade; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle; Interleukin-4 and Interleukin-13 signaling; PI3K events in ERBB4 signaling; PI3K events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; GAB1 signalosome; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by CSF1 (M-CSF) in myeloid cells; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; Signaling by FGFR2 in disease; PI-3K cascade:FGFR3; PI-3K cascade:FGFR4; Signaling by FGFR3 in disease; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; GP1b-IX-V activation signalling; MET activates PI3K/AKT signaling; Activated NTRK3 signals through PI3K; Activated NTRK2 signals through PI3K" "154" "0" "0.954" "1.006" "0.973" "0.964" "0.988" "0.977" "1.009" "0.972" "0.979" "2962.0" "2826.1" "2980.6" "2881.1" "2855.7" "2927.4" "2895.1" "2989.5" "2878.1" "2900.7" "" "" "" "" "" "" "" "" "" "" "2775.4" "2338.6" "2767.1" "2227.3" "2434.1" "2796.8" "2645.4" "2654.3" "2878.1" "2792.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "439747598683617185" "False" "High" "IsMasterProtein" "Q9UI10" "Translation initiation factor eIF2B subunit delta OS=Homo sapiens OX=9606 GN=EIF2B4 PE=1 SV=2" "0.000" "False" "38.359" "24" "11" "15" "11" "523" "57.5" "9.38" "47.61" "11" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "8890" "ENSG00000115211" "EIF2B4" "hsa:8890; Q53RY7; Q5BJF4; Q9BUV9; Q9UBG4; Q9UI10; Q9UIQ9; Q9UJ95" "Translation factors; Primary ovarian insufficiency" "Recycling of eIF2:GDP" "3" "0" "1.052" "1.031" "1.072" "1.047" "1.029" "1.009" "0.960" "1.008" "1.024" "757.0" "796.0" "780.2" "811.4" "792.4" "778.7" "763.9" "727.1" "762.8" "775.1" "" "" "" "" "" "" "" "" "" "" "709.3" "658.7" "724.3" "627.3" "675.4" "744.0" "698.0" "645.6" "762.8" "746.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8876035733125179295" "False" "High" "IsMasterProtein" "Q96D71" "RalBP1-associated Eps domain-containing protein 1 OS=Homo sapiens OX=9606 GN=REPS1 PE=1 SV=3" "0.000" "False" "38.344" "18" "13" "17" "13" "796" "86.6" "5.69" "46.81" "13" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12763" "85021" "ENSG00000135597" "REPS1" "B7ZBZ8; B7ZBZ9; B7ZC00; hsa:85021; J3KP76; Q5JWJ5; Q5JWJ6; Q5JWJ7; Q8NDR7; Q8WU62; Q96D71; Q9BXY9" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "1.009" "1.001" "1.069" "1.003" "1.035" "1.006" "1.027" "1.058" "1.056" "472.3" "476.7" "472.9" "504.7" "473.8" "488.6" "475.0" "485.2" "499.6" "498.8" "" "" "" "" "" "" "" "" "" "" "442.5" "394.5" "439.0" "390.2" "403.8" "466.9" "434.0" "430.8" "499.6" "480.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-797188196996991140" "False" "High" "IsMasterProtein" "P15170" "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A OS=Homo sapiens OX=9606 GN=GSPT1 PE=1 SV=1" "0.000" "False" "38.334" "27" "13" "22" "13" "499" "55.7" "5.62" "58.10" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "2935" "ENSG00000103342" "GSPT1" "hsa:2935; J3KQG6; P15170; Q96GF2" "" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "4" "0" "0.915" "0.990" "0.956" "0.926" "0.920" "0.937" "0.921" "0.889" "0.906" "2577.4" "2357.7" "2552.8" "2464.6" "2387.0" "2370.3" "2415.5" "2373.7" "2292.4" "2336.4" "" "" "" "" "" "" "" "" "" "" "2415.0" "1951.0" "2370.0" "1905.2" "2034.7" "2264.6" "2207.1" "2107.6" "2292.4" "2249.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-990721738298047914" "False" "High" "IsMasterProtein" "O00299" "Chloride intracellular channel protein 1 OS=Homo sapiens OX=9606 GN=CLIC1 PE=1 SV=4" "0.000" "False" "38.299" "58" "11" "16" "11" "241" "26.9" "5.17" "55.70" "11" "transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "transporter activity" "Pf13409, Pf13410" "1192" "ENSG00000206394; ENSG00000213719; ENSG00000223639; ENSG00000226248; ENSG00000226417; ENSG00000226651; ENSG00000230685" "CLIC1" "hsa:1192; O00299; Q15089; Q502X1" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.164" "0.937" "1.107" "0.963" "0.893" "0.748" "1.017" "1.112" "0.975" "1257.1" "1463.2" "1177.4" "1391.8" "1210.9" "1122.4" "940.5" "1278.5" "1397.6" "1225.0" "" "" "" "" "" "" "" "" "" "" "1177.9" "1210.8" "1093.1" "1075.9" "1032.1" "1072.3" "859.4" "1135.2" "1397.6" "1179.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4664258247594329003" "False" "High" "IsMasterProtein" "Q9H9B1" "Histone-lysine N-methyltransferase EHMT1 OS=Homo sapiens OX=9606 GN=EHMT1 PE=1 SV=4" "0.000" "False" "38.284" "12" "12" "18" "11" "1298" "141.4" "5.76" "55.75" "12" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00856, Pf05033, Pf12796, Pf21533" "79813" "ENSG00000181090" "EHMT1" "B1AQ58; B1AQ59; hsa:79813; Q86X08; Q8TCN7; Q96F53; Q96JF1; Q96KH4; Q9H9B1" "Histone modifications; MTHFR deficiency; Kleefstra syndrome" "PKMTs methylate histone lysines; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by E2F6; Transcriptional Regulation by VENTX; Regulation of TP53 Activity through Methylation" "8" "1" "1.033" "1.035" "1.084" "1.069" "1.079" "1.038" "1.068" "1.067" "1.056" "1156.0" "1194.2" "1196.9" "1252.9" "1235.8" "1246.9" "1200.4" "1235.0" "1233.2" "1220.6" "" "" "" "" "" "" "" "" "" "" "1083.2" "988.2" "1111.1" "968.6" "1053.3" "1191.3" "1096.8" "1096.5" "1233.2" "1175.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-560084501499272066" "False" "High" "IsMasterProtein" "Q8IY18" "Structural maintenance of chromosomes protein 5 OS=Homo sapiens OX=9606 GN=SMC5 PE=1 SV=2" "0.000" "False" "38.278" "13" "14" "14" "14" "1101" "128.7" "8.38" "42.50" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463" "23137" "ENSG00000198887" "SMC5" "A6NM81; hsa:23137; O60335; Q05D92; Q5VZ60; Q8IY18; Q96SB9" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "0.940" "0.997" "1.040" "1.042" "1.019" "0.979" "1.021" "0.987" "1.080" "750.4" "705.7" "748.5" "780.5" "781.6" "764.9" "734.4" "765.8" "740.3" "810.7" "" "" "" "" "" "" "" "" "" "" "703.1" "583.9" "694.9" "603.3" "666.2" "730.7" "671.0" "680.0" "740.3" "780.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8818107332528144144" "False" "High" "IsMasterProtein" "Q9H4E7" "Differentially expressed in FDCP 6 homolog OS=Homo sapiens OX=9606 GN=DEF6 PE=1 SV=1" "0.000" "False" "38.263" "20" "13" "16" "13" "631" "73.9" "6.05" "55.76" "13" "transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00169" "50619" "ENSG00000023892" "DEF6" "hsa:50619; Q86VF4; Q9H4E7" "" "CDC42 GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle" "4" "0" "1.071" "0.997" "1.020" "1.046" "1.040" "1.008" "1.021" "1.020" "1.046" "1637.7" "1753.3" "1633.4" "1671.2" "1712.3" "1703.0" "1650.5" "1672.2" "1669.9" "1712.9" "" "" "" "" "" "" "" "" "" "" "1534.5" "1450.8" "1516.4" "1291.9" "1459.5" "1627.1" "1508.1" "1484.7" "1669.9" "1649.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5487682516941207466" "False" "High" "IsMasterProtein" "P98171" "Rho GTPase-activating protein 4 OS=Homo sapiens OX=9606 GN=ARHGAP4 PE=1 SV=2" "0.000" "False" "38.222" "15" "14" "16" "14" "946" "105.0" "6.34" "50.56" "14" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00611, Pf00620, Pf14604" "393" "ENSG00000089820" "ARHGAP4" "hsa:393; P98171; Q14144; Q86UY3" "Clock-controlled autophagy in bone metabolism" "RAC1 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle" "4" "0" "1.001" "1.040" "0.989" "1.037" "1.046" "0.966" "0.979" "0.973" "1.003" "1980.7" "1982.5" "2059.6" "1959.1" "2053.5" "2071.5" "1912.9" "1939.0" "1927.1" "1986.9" "" "" "" "" "" "" "" "" "" "" "1855.9" "1640.5" "1912.0" "1514.5" "1750.4" "1979.1" "1747.9" "1721.7" "1927.1" "1913.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5288684708523747991" "False" "High" "IsMasterProtein" "Q14240" "Eukaryotic initiation factor 4A-II OS=Homo sapiens OX=9606 GN=EIF4A2 PE=1 SV=2" "0.000" "False" "38.218" "29" "12" "35" "4" "407" "46.4" "5.48" "91.96" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1974" "ENSG00000156976" "EIF4A2" "D3DNU9; hsa:1974; Q14240; Q53XJ6; Q96B90; Q96EA8" "Translation factors; Translation inhibitors in chronically activated PDGFRA cells" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; Z-decay: degradation of maternal mRNAs by zygotically expressed factors; Translation initiation complex formation; Ribosomal scanning and start codon recognition" "11" "0" "0.935" "1.014" "0.951" "1.008" "0.973" "0.989" "0.987" "1.040" "0.994" "1007.8" "942.3" "1022.4" "958.2" "1015.6" "980.7" "996.9" "994.5" "1048.4" "1001.5" "" "" "" "" "" "" "" "" "" "" "944.3" "779.7" "949.2" "740.7" "865.6" "936.9" "910.9" "883.0" "1048.4" "964.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-997186877852076993" "False" "High" "IsMasterProtein" "Q9NYL9" "Tropomodulin-3 OS=Homo sapiens OX=9606 GN=TMOD3 PE=1 SV=1" "0.000" "False" "38.212" "39" "13" "18" "13" "352" "39.6" "5.19" "53.22" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton" "cytoskeletal activity" "Pf03250" "29766" "ENSG00000138594" "TMOD3" "B2R6G7; hsa:29766; Q9NT43; Q9NYL9; Q9NZR0" "VEGFA-VEGFR2 signaling" "Striated Muscle Contraction; RND3 GTPase cycle; RHOBTB2 GTPase cycle" "4" "0" "1.034" "1.017" "1.044" "1.070" "1.127" "1.029" "1.081" "1.094" "1.099" "1869.0" "1933.2" "1900.1" "1952.0" "2000.1" "2105.8" "1923.7" "2020.1" "2045.4" "2053.3" "" "" "" "" "" "" "" "" "" "" "1751.3" "1599.7" "1764.0" "1508.9" "1704.8" "2011.9" "1757.7" "1793.6" "2045.4" "1977.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2179215368678635356" "False" "High" "IsMasterProtein" "Q8IYB8" "ATP-dependent RNA helicase SUPV3L1, mitochondrial OS=Homo sapiens OX=9606 GN=SUPV3L1 PE=1 SV=1" "0.000" "False" "38.195" "15" "10" "17" "10" "786" "87.9" "7.99" "56.95" "10" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00271, Pf12513, Pf18114, Pf18147" "6832" "ENSG00000156502" "SUPV3L1" "A8K301; hsa:6832; O43630; Q8IYB8" "" "Mitochondrial RNA degradation" "1" "0" "1.048" "1.120" "1.183" "1.179" "1.185" "1.157" "1.214" "1.194" "1.158" "794.2" "832.2" "889.5" "939.3" "936.5" "941.3" "919.2" "964.5" "948.4" "919.6" "" "" "" "" "" "" "" "" "" "" "744.1" "688.6" "825.8" "726.1" "798.2" "899.3" "839.9" "856.4" "948.4" "885.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1687384969150092260" "False" "High" "IsMasterProtein" "Q96B97" "SH3 domain-containing kinase-binding protein 1 OS=Homo sapiens OX=9606 GN=SH3KBP1 PE=1 SV=2" "0.000" "False" "38.173" "23" "13" "18" "13" "665" "73.1" "6.62" "49.52" "13" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf14604" "30011" "ENSG00000147010" "SH3KBP1" "B7Z1D5; hsa:30011; Q5JPT4; Q5JPT5; Q8IWX6; Q8IX98; Q96B97; Q96RN4; Q9NYR0" "EGF/EGFR signaling pathway" "Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Reelin signalling pathway" "9" "0" "1.035" "1.033" "1.023" "1.072" "1.051" "1.031" "1.072" "1.027" "1.067" "1464.6" "1515.2" "1512.2" "1498.5" "1570.4" "1538.6" "1510.7" "1570.4" "1504.0" "1563.1" "" "" "" "" "" "" "" "" "" "" "1372.3" "1253.8" "1403.9" "1158.4" "1338.5" "1470.0" "1380.4" "1394.3" "1504.0" "1505.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5005223025872710581" "False" "High" "IsMasterProtein" "O60524" "Ribosome quality control complex subunit NEMF OS=Homo sapiens OX=9606 GN=NEMF PE=1 SV=4" "0.000" "False" "38.165" "12" "13" "19" "13" "1076" "122.9" "6.35" "56.47" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf05670, Pf05833, Pf11923" "9147" "ENSG00000165525" "NEMF" "A0JLQ3; B3KSK1; B4DDL3; B4DHA9; B4E3F3; hsa:9147; O60524; Q32Q66; Q8WW70; Q9NWG1" "" "" "0" "0" "0.985" "1.042" "1.012" "1.075" "1.059" "0.964" "1.027" "0.990" "1.075" "1363.3" "1342.4" "1420.0" "1380.3" "1465.5" "1443.8" "1313.6" "1399.6" "1349.9" "1465.0" "" "" "" "" "" "" "" "" "" "" "1277.4" "1110.8" "1318.3" "1067.1" "1249.2" "1379.4" "1200.3" "1242.7" "1349.9" "1410.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "467994795181612484" "False" "High" "IsMasterProtein" "Q92793" "CREB-binding protein OS=Homo sapiens OX=9606 GN=CREBBP PE=1 SV=3" "0.000" "False" "38.057" "6" "15" "19" "8" "2442" "265.2" "8.53" "49.57" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00569, Pf02135, Pf02172, Pf06001, Pf08214, Pf09030" "1387" "ENSG00000005339" "CREBBP" "D3DUC9; O00147; Q16376; Q4LE28; Q92793" "Androgen receptor signaling pathway; Angiogenesis; TNF-alpha signaling pathway; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; IL6 signaling pathway; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; miRNA regulation of prostate cancer signaling pathways; Wnt signaling pathway and pluripotency; Clear cell renal cell carcinoma pathways; Ebola virus infection in host; Type 2 papillary renal cell carcinoma; Ciliary landscape; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; 15q13.3 copy number variation syndrome; Urotensin-II-mediated signaling pathway; Rubinstein-Taybi syndrome 1; 15q11q13 copy number variation; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "Heme signaling; NFE2L2 regulating anti-oxidant/detoxification enzymes; Transcriptional regulation of white adipocyte differentiation; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Zygotic genome activation (ZGA); PPARA activates gene expression; NPAS4 regulates expression of target genes; Formation of the beta-catenin:TCF transactivating complex; SUMOylation of transcription cofactors; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); HATs acetylate histones; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; NFE2L2 regulating MDR associated enzymes; Nuclear events mediated by NFE2L2; NFE2L2 regulates pentose phosphate pathway genes; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; NFE2L2 regulating inflammation associated genes; NFE2L2 regulating tumorigenic genes; NFE2L2 regulating ER-stress associated genes; Regulation of NFE2L2 gene expression; RORA activates gene expression; Attenuation phase; CD209 (DC-SIGN) signaling; Activation of the TFAP2 (AP-2) family of transcription factors; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; Regulation of gene expression by Hypoxia-inducible Factor; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production" "74" "5" "0.901" "0.905" "0.924" "0.916" "0.918" "0.921" "0.931" "0.870" "0.917" "2417.9" "2178.4" "2187.6" "2234.9" "2215.7" "2219.1" "2227.4" "2251.2" "2104.1" "2218.4" "" "" "" "" "" "" "" "" "" "" "2265.6" "1802.6" "2030.9" "1727.7" "1888.6" "2120.2" "2035.3" "1998.8" "2104.1" "2136.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1437948072660631583" "False" "High" "IsMasterProtein" "O60664" "Perilipin-3 OS=Homo sapiens OX=9606 GN=PLIN3 PE=1 SV=3" "0.000" "False" "38.052" "33" "11" "19" "11" "434" "47.0" "5.44" "63.32" "11" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf03036" "10226" "ENSG00000105355" "PLIN3" "A8K4Y9; hsa:10226; K7EQF4; O60664; Q53G77; Q9BS03; Q9UBD7; Q9UP92" "" "Late endosomal microautophagy; Triglyceride catabolism; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle; Lipophagy; Chaperone Mediated Autophagy" "6" "0" "1.002" "0.932" "0.968" "0.977" "1.039" "1.097" "1.096" "1.079" "0.982" "1806.0" "1810.4" "1683.5" "1748.1" "1764.6" "1876.4" "1981.9" "1979.6" "1947.9" "1773.8" "" "" "" "" "" "" "" "" "" "" "1692.2" "1498.1" "1562.9" "1351.3" "1504.1" "1792.7" "1811.0" "1757.7" "1947.9" "1707.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4877503792566385355" "False" "High" "IsMasterProtein" "O75822" "Eukaryotic translation initiation factor 3 subunit J OS=Homo sapiens OX=9606 GN=EIF3J PE=1 SV=2" "0.000" "False" "38.052" "45" "11" "18" "10" "258" "29.0" "4.83" "65.00" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08597" "8669" "ENSG00000104131" "EIF3J" "B4DUI3; F5H425; hsa:8669; O75822; Q9BUD2; Q9H8Q2; Q9UI65" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "1.023" "0.942" "0.920" "0.974" "0.980" "1.120" "1.092" "1.028" "0.995" "2421.3" "2476.5" "2281.8" "2227.1" "2358.4" "2373.5" "2711.3" "2643.5" "2488.1" "2409.1" "" "" "" "" "" "" "" "" "" "" "2268.7" "2049.3" "2118.4" "1721.6" "2010.3" "2267.7" "2477.4" "2347.1" "2488.1" "2319.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2819385337701029723" "False" "High" "IsMasterProtein" "Q9UHB9" "Signal recognition particle subunit SRP68 OS=Homo sapiens OX=9606 GN=SRP68 PE=1 SV=2" "0.000" "False" "38.045" "22" "12" "14" "12" "627" "70.7" "8.56" "42.82" "12" "other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf16969" "6730" "ENSG00000167881" "SRP68" "B3KUU5; B3KWY7; G3V1U4; hsa:6730; Q8NCJ4; Q8WUK2; Q9UHB9" "" "SRP-dependent cotranslational protein targeting to membrane" "1" "0" "0.999" "0.991" "1.085" "1.029" "0.949" "1.029" "0.943" "0.964" "0.974" "929.8" "928.9" "921.6" "1008.4" "956.5" "882.3" "956.5" "876.5" "896.1" "905.6" "" "" "" "" "" "" "" "" "" "" "871.2" "768.6" "855.6" "779.6" "815.3" "842.9" "873.9" "778.2" "896.1" "872.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7573385717766537595" "False" "High" "IsMasterProtein" "Q9GZT9" "Egl nine homolog 1 OS=Homo sapiens OX=9606 GN=EGLN1 PE=1 SV=1" "0.000" "False" "38.018" "32" "11" "14" "11" "426" "46.0" "8.53" "49.35" "11" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01753, Pf13640" "54583" "ENSG00000135766" "EGLN1" "hsa:54583; Q8N3M8; Q9BZS8; Q9BZT0; Q9GZT9" "Photodynamic therapy-induced HIF-1 survival signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Type 2 papillary renal cell carcinoma; Markers of kidney cell lineage" "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha" "5" "0" "1.102" "1.001" "0.999" "1.010" "0.992" "0.929" "0.971" "1.000" "1.021" "1581.9" "1743.4" "1583.8" "1580.0" "1597.0" "1569.5" "1469.1" "1535.4" "1581.4" "1615.3" "" "" "" "" "" "" "" "" "" "" "1482.2" "1442.7" "1470.3" "1221.4" "1361.3" "1499.5" "1342.3" "1363.3" "1581.4" "1555.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4157182932771800811" "False" "High" "IsMasterProtein" "Q07955" "Serine/arginine-rich splicing factor 1 OS=Homo sapiens OX=9606 GN=SRSF1 PE=1 SV=2" "0.000" "False" "37.873" "45" "10" "19" "10" "248" "27.7" "10.36" "52.95" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6426" "ENSG00000136450" "SRSF1" "B2R6Z7; D3DTZ3; hsa:6426; Q07955; Q13809" "mRNA processing" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "7" "0" "1.067" "1.097" "0.998" "0.989" "1.002" "0.977" "0.933" "0.895" "0.974" "1690.0" "1802.5" "1853.9" "1686.7" "1670.9" "1694.2" "1651.9" "1576.3" "1512.8" "1645.4" "" "" "" "" "" "" "" "" "" "" "1583.6" "1491.5" "1721.2" "1303.9" "1424.2" "1618.7" "1509.4" "1399.6" "1512.8" "1584.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "419048109363271085" "False" "High" "IsMasterProtein" "Q10713" "Mitochondrial-processing peptidase subunit alpha OS=Homo sapiens OX=9606 GN=PMPCA PE=1 SV=2" "0.000" "False" "37.862" "24" "12" "20" "12" "525" "58.2" "6.92" "55.62" "12" "protein metabolism;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf00675, Pf05193" "23203" "ENSG00000165688" "PMPCA" "B4DKL3; E7ET61; hsa:23203; Q10713; Q16639; Q5SXM9; Q8N513" "" "Mitochondrial protein import; Mitochondrial protein degradation; Processing of SMDT1" "3" "0" "1.014" "1.039" "1.082" "1.061" "1.038" "1.012" "1.030" "1.076" "1.053" "1190.1" "1207.2" "1236.6" "1288.0" "1263.2" "1235.5" "1204.9" "1226.3" "1281.1" "1253.3" "" "" "" "" "" "" "" "" "" "" "1115.1" "999.0" "1148.0" "995.7" "1076.8" "1180.4" "1101.0" "1088.9" "1281.1" "1206.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3574208382527803870" "False" "High" "IsMasterProtein" "Q9Y2X7" "ARF GTPase-activating protein GIT1 OS=Homo sapiens OX=9606 GN=GIT1 PE=1 SV=2" "0.000" "False" "37.849" "18" "14" "20" "11" "761" "84.3" "6.80" "58.83" "14" "transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf01412, Pf08518, Pf12205, Pf12796, Pf16559" "28964" "ENSG00000108262" "GIT1" "B4DGU9; B4DSV3; hsa:28964; Q86SS0; Q9BRJ4; Q9Y2X7" "CAMKK2 pathway; Regulation of actin cytoskeleton" "RHOJ GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Ephrin signaling; Activation of RAC1 downstream of NMDARs" "12" "2" "1.038" "0.995" "1.017" "1.033" "1.023" "0.972" "0.986" "0.990" "1.024" "1645.9" "1709.2" "1637.8" "1674.6" "1701.0" "1683.3" "1599.0" "1622.4" "1629.3" "1685.8" "" "" "" "" "" "" "" "" "" "" "1542.2" "1414.4" "1520.5" "1294.5" "1449.9" "1608.2" "1461.1" "1440.6" "1629.3" "1623.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4354305271704446850" "False" "High" "IsMasterProtein" "O95248" "Myotubularin-related protein 5 OS=Homo sapiens OX=9606 GN=SBF1 PE=1 SV=4" "0.000" "False" "37.837" "8" "13" "14" "13" "1868" "208.3" "6.90" "39.49" "13" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf02141, Pf02893, Pf03456, Pf06602, Pf12335" "6305" "ENSG00000100241" "SBF1" "A0A024R4Z9; A6PVG9; G5E933; hsa:6305; O60228; O95248; Q5JXD8; Q5PPM2; Q96GR9; Q9UGB8" "" "RAB GEFs exchange GTP for GDP on RABs; Synthesis of PIPs at the ER membrane" "2" "0" "0.998" "0.989" "1.010" "0.990" "0.953" "1.000" "0.947" "0.918" "0.959" "1311.5" "1308.4" "1296.7" "1325.3" "1299.0" "1249.3" "1312.1" "1242.2" "1203.5" "1257.2" "" "" "" "" "" "" "" "" "" "" "1228.9" "1082.7" "1203.8" "1024.5" "1107.3" "1193.6" "1198.9" "1103.0" "1203.5" "1210.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2703376622299265366" "False" "High" "IsMasterProtein" "Q9UKF6" "Cleavage and polyadenylation specificity factor subunit 3 OS=Homo sapiens OX=9606 GN=CPSF3 PE=1 SV=1" "0.000" "False" "37.832" "19" "12" "13" "12" "684" "77.4" "5.60" "42.98" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07521, Pf10996, Pf11718, Pf16661" "51692" "ENSG00000119203" "CPSF3" "hsa:51692; O14769; Q53RS2; Q96F36; Q9UKF6" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Transport of Mature mRNA Derived from an Intronless Transcript" "6" "0" "0.969" "0.997" "1.060" "1.046" "1.045" "1.116" "1.137" "1.053" "1.060" "1350.1" "1307.8" "1346.4" "1430.9" "1412.3" "1411.4" "1506.9" "1534.9" "1421.3" "1431.1" "" "" "" "" "" "" "" "" "" "" "1265.0" "1082.2" "1249.9" "1106.2" "1203.8" "1348.4" "1376.9" "1362.8" "1421.3" "1378.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2021642276248058836" "False" "High" "IsMasterProtein" "Q8TD30" "Alanine aminotransferase 2 OS=Homo sapiens OX=9606 GN=GPT2 PE=1 SV=1" "0.000" "False" "37.821" "26" "12" "16" "12" "523" "57.9" "7.71" "51.86" "12" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00155" "84706" "ENSG00000166123" "GPT2" "hsa:84706; Q8N9E2; Q8TD30" "Amino acid metabolism; Amino acid metabolism pathway excerpt: histidine catabolism extension" "" "2" "0" "1.017" "0.993" "0.986" "1.015" "1.033" "0.978" "1.017" "0.986" "1.036" "1460.9" "1485.7" "1450.6" "1440.1" "1482.2" "1509.6" "1429.4" "1486.2" "1439.9" "1513.1" "" "" "" "" "" "" "" "" "" "" "1368.9" "1229.4" "1346.7" "1113.2" "1263.4" "1442.3" "1306.1" "1319.6" "1439.9" "1456.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6626039175338175676" "False" "High" "IsMasterProtein" "Q9NXH9" "tRNA (guanine(26)-N(2))-dimethyltransferase OS=Homo sapiens OX=9606 GN=TRMT1 PE=1 SV=1" "0.000" "False" "37.761" "21" "13" "16" "13" "659" "72.2" "7.64" "54.19" "13" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00642, Pf02005" "55621" "ENSG00000104907" "TRMT1" "hsa:55621; O76103; Q548Y5; Q8WVA6; Q9NXH9" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.050" "0.985" "1.025" "1.016" "0.975" "1.038" "1.004" "0.996" "0.955" "1375.5" "1444.3" "1354.7" "1409.4" "1397.4" "1341.4" "1427.5" "1380.6" "1369.6" "1314.3" "" "" "" "" "" "" "" "" "" "" "1288.9" "1195.1" "1257.7" "1089.5" "1191.1" "1281.6" "1304.4" "1225.8" "1369.6" "1265.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2098807042560158640" "False" "High" "IsMasterProtein" "P13489" "Ribonuclease inhibitor OS=Homo sapiens OX=9606 GN=RNH1 PE=1 SV=2" "0.000" "False" "37.668" "30" "12" "16" "12" "461" "49.9" "4.82" "56.35" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf13516, Pf18779" "6050" "ENSG00000023191; ENSG00000276230" "RNH1" "hsa:6050; P13489; Q8IZK8; Q96FD7; Q9BQ80; Q9UDK6" "" "" "0" "0" "1.028" "0.994" "1.066" "0.996" "0.975" "0.991" "0.977" "0.978" "0.978" "2233.3" "2294.7" "2218.9" "2381.7" "2223.7" "2176.8" "2213.8" "2181.4" "2183.8" "2185.0" "" "" "" "" "" "" "" "" "" "" "2092.6" "1898.8" "2059.9" "1841.1" "1895.4" "2079.7" "2022.8" "1936.9" "2183.8" "2103.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5810129024139572187" "False" "High" "IsMasterProtein" "P34931" "Heat shock 70 kDa protein 1-like OS=Homo sapiens OX=9606 GN=HSPA1L PE=1 SV=2" "0.000" "False" "37.658" "18" "11" "41" "1" "641" "70.3" "6.02" "132.10" "11" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00012" "3305" "ENSG00000204390; ENSG00000206383; ENSG00000234258; ENSG00000236251" "HSPA1L" "A6NNB0; B0UXW8; hsa:3305; O75634; P34931; Q2HXR3; Q8NE72; Q96QC9; Q9UQM1" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Measles virus infection" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Regulation of HSF1-mediated heat shock response; Attenuation phase" "8" "0" "1.066" "1.000" "1.370" "1.154" "0.909" "1.306" "0.938" "0.961" "1.046" "384.9" "410.4" "384.7" "527.2" "444.1" "349.7" "502.6" "361.1" "369.8" "402.4" "" "" "" "" "" "" "" "" "" "" "360.6" "339.6" "357.1" "407.5" "378.5" "334.1" "459.2" "320.6" "369.8" "387.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8431694603937659134" "False" "High" "IsMasterProtein" "P15531" "Nucleoside diphosphate kinase A OS=Homo sapiens OX=9606 GN=NME1 PE=1 SV=1" "0.000" "False" "37.652" "58" "9" "34" "4" "152" "17.1" "6.19" "120.87" "9" "DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "translation activity;kinase activity;other molecular function" "Pf00334" "4830" "ENSG00000239672" "NME1" "hsa:4830; P15531; Q6FGK3; Q86XQ2; Q9UDJ6" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates; Azathioprine ADME; Ribavirin ADME" "4" "0" "0.939" "1.006" "0.929" "0.944" "0.989" "0.919" "0.960" "1.009" "1.006" "1739.1" "1632.3" "1749.9" "1615.4" "1641.4" "1719.8" "1598.6" "1669.2" "1754.6" "1749.3" "" "" "" "" "" "" "" "" "" "" "1629.5" "1350.7" "1624.6" "1248.7" "1399.1" "1643.1" "1460.7" "1482.1" "1754.6" "1684.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7309351128836490355" "False" "High" "IsMasterProtein" "P26583" "High mobility group protein B2 OS=Homo sapiens OX=9606 GN=HMGB2 PE=1 SV=2" "0.000" "False" "37.631" "43" "10" "33" "9" "209" "24.0" "7.81" "93.60" "10" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "3148" "ENSG00000164104" "HMGB2" "B2R4K8; D3DP37; hsa:3148; P26583; Q5U072" "Retinoblastoma gene in cancer; Ectoderm differentiation; Ectoderm differentiation" "Apoptosis induced DNA fragmentation" "4" "1" "1.094" "1.052" "1.046" "1.004" "1.007" "1.026" "1.011" "1.079" "1.061" "3700.1" "4047.0" "3892.5" "3869.2" "3715.5" "3726.8" "3796.2" "3742.4" "3992.7" "3924.4" "" "" "" "" "" "" "" "" "" "" "3467.0" "3348.8" "3613.7" "2991.1" "3167.0" "3560.6" "3468.7" "3322.9" "3992.7" "3778.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4997024104720897707" "False" "High" "IsMasterProtein" "Q9BZK7" "F-box-like/WD repeat-containing protein TBL1XR1 OS=Homo sapiens OX=9606 GN=TBL1XR1 PE=1 SV=1" "0.000" "False" "37.627" "25" "10" "14" "6" "514" "55.6" "5.55" "48.87" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf08513" "79718" "ENSG00000177565" "TBL1XR1" "D3DNQ9; hsa:79718; Q14DC3; Q9BZK7; Q9H2I1; Q9H9A1" "Rett syndrome" "Heme signaling; Transcriptional activation of mitochondrial biogenesis; HCMV Early Events; HDACs deacetylate histones; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression" "20" "2" "0.952" "1.031" "0.982" "1.014" "0.974" "0.964" "1.010" "1.053" "0.985" "1674.4" "1594.6" "1725.5" "1644.6" "1697.7" "1631.3" "1614.8" "1690.4" "1763.4" "1649.2" "" "" "" "" "" "" "" "" "" "" "1568.9" "1319.5" "1601.9" "1271.3" "1447.0" "1558.5" "1475.5" "1500.9" "1763.4" "1588.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7670404762929313903" "False" "High" "IsMasterProtein" "Q9BYW2" "Histone-lysine N-methyltransferase SETD2 OS=Homo sapiens OX=9606 GN=SETD2 PE=1 SV=3" "0.000" "False" "37.585" "6" "16" "18" "16" "2564" "287.4" "6.14" "49.81" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00397, Pf00856, Pf08236, Pf17907" "29072" "ENSG00000181555" "SETD2" "hsa:29072; O75397; O75405; Q17RW8; Q5BKS9; Q5QGN2; Q69YI5; Q6IN64; Q6ZN53; Q6ZS25; Q8N3R0; Q8TCN0; Q9BYW2; Q9C0D1; Q9H696; Q9NZW9" "Histone modifications; Mesodermal commitment pathway; Mesodermal commitment pathway; Pathways affected in adenoid cystic carcinoma; Clear cell renal cell carcinoma pathways; Type 2 papillary renal cell carcinoma; Pleural mesothelioma" "PKMTs methylate histone lysines" "8" "0" "1.007" "1.019" "1.054" "1.105" "1.103" "1.166" "1.162" "1.146" "1.107" "1513.3" "1523.3" "1541.8" "1594.5" "1671.6" "1669.2" "1764.4" "1758.6" "1734.1" "1675.2" "" "" "" "" "" "" "" "" "" "" "1417.9" "1260.5" "1431.4" "1232.6" "1424.8" "1594.8" "1612.2" "1561.4" "1734.1" "1613.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8165870367093882655" "False" "High" "IsMasterProtein" "Q86TI2" "Dipeptidyl peptidase 9 OS=Homo sapiens OX=9606 GN=DPP9 PE=1 SV=3" "0.000" "False" "37.569" "14" "12" "18" "11" "863" "98.2" "6.46" "54.85" "12" "protein metabolism;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00326, Pf00930, Pf19520" "91039" "ENSG00000142002" "DPP9" "hsa:91039; O75273; O75868; Q1ZZB8; Q6AI37; Q6UAL0; Q6ZMT2; Q6ZNJ5; Q86TI2; Q8N2J7; Q8N3F5; Q8WXD8; Q96NT8; Q9BVR3" "Lung fibrosis" "" "1" "1" "0.906" "1.024" "0.996" "0.980" "0.980" "1.018" "1.037" "1.022" "1.006" "2870.4" "2600.4" "2940.4" "2859.3" "2811.5" "2813.8" "2922.1" "2976.0" "2932.7" "2888.4" "" "" "" "" "" "" "" "" "" "" "2689.5" "2151.8" "2729.8" "2210.4" "2396.5" "2688.3" "2670.0" "2642.4" "2932.7" "2781.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8621700409293052339" "False" "High" "IsMasterProtein" "P23368" "NAD-dependent malic enzyme, mitochondrial OS=Homo sapiens OX=9606 GN=ME2 PE=1 SV=1" "0.000" "False" "37.565" "22" "12" "18" "12" "584" "65.4" "7.61" "51.89" "12" "other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00390, Pf03949" "4200" "ENSG00000082212" "ME2" "B2R8J2; hsa:4200; P23368; Q9BWL6; Q9BYG1; Q9H4B2" "TCA cycle in senescence" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "3" "0" "1.051" "1.078" "1.029" "1.093" "1.075" "1.036" "1.094" "1.069" "1.071" "1521.4" "1598.7" "1640.8" "1566.2" "1662.7" "1635.9" "1576.4" "1665.1" "1626.0" "1629.4" "" "" "" "" "" "" "" "" "" "" "1425.6" "1322.9" "1523.2" "1210.7" "1417.3" "1562.9" "1440.4" "1478.4" "1626.0" "1568.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4326632445175340721" "False" "High" "IsMasterProtein" "P55209" "Nucleosome assembly protein 1-like 1 OS=Homo sapiens OX=9606 GN=NAP1L1 PE=1 SV=1" "0.000" "False" "37.557" "26" "6" "17" "5" "391" "45.3" "4.46" "61.88" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00956" "4673" "ENSG00000187109" "NAP1L1" "B3KNT8; B3KV44; hsa:4673; P55209" "VEGFA-VEGFR2 signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "" "2" "0" "1.054" "1.115" "0.998" "1.074" "1.109" "0.949" "1.082" "0.970" "1.026" "914.4" "964.2" "1019.4" "912.2" "981.9" "1013.9" "867.9" "989.0" "886.8" "937.9" "" "" "" "" "" "" "" "" "" "" "856.8" "797.8" "946.4" "705.1" "837.0" "968.7" "793.1" "878.2" "886.8" "903.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6077570543552496726" "False" "High" "IsMasterProtein" "Q8N1G4" "Leucine-rich repeat-containing protein 47 OS=Homo sapiens OX=9606 GN=LRRC47 PE=1 SV=1" "0.000" "False" "37.541" "22" "12" "17" "12" "583" "63.4" "8.28" "60.52" "12" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00560, Pf13855" "57470" "ENSG00000130764" "LRRC47" "hsa:57470; Q8N1G4; Q9ULN5" "" "" "0" "0" "0.996" "1.019" "0.995" "1.002" "1.028" "0.997" "1.004" "0.991" "0.991" "1941.8" "1933.8" "1978.9" "1931.8" "1945.7" "1995.4" "1935.7" "1950.3" "1923.9" "1924.2" "" "" "" "" "" "" "" "" "" "" "1819.4" "1600.2" "1837.2" "1493.4" "1658.4" "1906.4" "1768.7" "1731.7" "1923.9" "1852.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7002487047349753336" "False" "High" "IsMasterProtein" "P22392" "Nucleoside diphosphate kinase B OS=Homo sapiens OX=9606 GN=NME2 PE=1 SV=1" "0.000" "False" "37.511" "59" "10" "40" "1" "152" "17.3" "8.41" "124.56" "10" "cell adhesion;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00334" "4831; 654364" "ENSG00000243678" "NME2" "A8MWA3; hsa:4831; hsa:654364; P22392; Q1WM23; Q6LCT6" "Pyrimidine metabolism" "Azathioprine ADME; Neutrophil degranulation; Interconversion of nucleotide di- and triphosphates; Ribavirin ADME" "5" "9" "1.050" "0.951" "1.005" "0.955" "0.999" "0.913" "0.959" "1.040" "0.958" "3908.4" "4104.6" "3718.1" "3929.2" "3734.4" "3905.6" "3569.6" "3749.7" "4065.0" "3744.9" "" "" "" "" "" "" "" "" "" "" "3662.2" "3396.5" "3451.8" "3037.4" "3183.1" "3731.5" "3261.7" "3329.3" "4065.0" "3605.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4198310778640922638" "False" "High" "IsMasterProtein" "Q9Y3F4" "Serine-threonine kinase receptor-associated protein OS=Homo sapiens OX=9606 GN=STRAP PE=1 SV=1" "0.000" "False" "37.487" "37" "11" "16" "11" "350" "38.4" "5.12" "61.14" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00400" "11171" "ENSG00000023734" "STRAP" "B2R5S5; B4DNJ6; hsa:11171; Q5TZT4; Q9NTK0; Q9UQC8; Q9Y3F4" "TGF-beta signaling pathway; Epithelial to mesenchymal transition in colorectal cancer" "Downregulation of TGF-beta receptor signaling" "3" "0" "0.907" "1.018" "0.946" "0.972" "1.012" "0.917" "0.958" "0.982" "1.011" "2545.9" "2308.9" "2590.8" "2408.1" "2475.6" "2576.0" "2335.2" "2437.9" "2500.4" "2573.3" "" "" "" "" "" "" "" "" "" "" "2385.5" "1910.6" "2405.2" "1861.6" "2110.2" "2461.1" "2133.8" "2164.6" "2500.4" "2477.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1619484696952214884" "False" "High" "IsMasterProtein" "P24534" "Elongation factor 1-beta OS=Homo sapiens OX=9606 GN=EEF1B2 PE=1 SV=3" "0.000" "False" "37.459" "47" "9" "26" "7" "225" "24.7" "4.67" "85.53" "9" "protein metabolism;other metabolic processes" "cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf00736, Pf10587" "1933" "ENSG00000114942; ENSG00000283391" "EEF1B2" "A8K795; hsa:1933; P24534; Q6IBH9" "Translation factors" "Eukaryotic Translation Elongation" "2" "0" "0.960" "1.018" "0.835" "0.937" "0.976" "0.890" "0.971" "0.926" "0.948" "2050.3" "1967.4" "2087.9" "1712.1" "1920.3" "2000.3" "1824.4" "1990.0" "1899.0" "1944.4" "" "" "" "" "" "" "" "" "" "" "1921.1" "1628.0" "1938.4" "1323.5" "1636.8" "1911.1" "1667.0" "1767.0" "1899.0" "1872.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5557556089384344895" "False" "High" "IsMasterProtein" "Q9UN86" "Ras GTPase-activating protein-binding protein 2 OS=Homo sapiens OX=9606 GN=G3BP2 PE=1 SV=2" "0.000" "False" "37.404" "23" "12" "29" "12" "482" "54.1" "5.55" "64.36" "12" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02136" "9908" "ENSG00000138757" "G3BP2" "A8K6X1; hsa:9908; O60606; O75149; Q9UN86; Q9UPA1" "" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "1" "0" "1.021" "1.035" "1.026" "1.061" "1.044" "1.020" "1.075" "1.003" "1.035" "3247.3" "3314.7" "3359.5" "3331.9" "3446.4" "3390.5" "3313.7" "3490.4" "3256.5" "3359.5" "" "" "" "" "" "" "" "" "" "" "3042.7" "2742.8" "3118.8" "2575.7" "2937.6" "3239.3" "3027.8" "3099.1" "3256.5" "3234.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8782574511401724651" "False" "High" "IsMasterProtein" "Q06124" "Tyrosine-protein phosphatase non-receptor type 11 OS=Homo sapiens OX=9606 GN=PTPN11 PE=1 SV=3" "0.000" "False" "37.378" "22" "13" "19" "13" "593" "68.0" "7.30" "62.96" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00102" "5781" "ENSG00000179295" "PTPN11" "A8K1D9; hsa:5781; Q06124; Q96HD7" "IL-5 signaling pathway; Heart development; IL-1 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Pilocytic astrocytoma; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; Embryonic stem cell pluripotency pathways; IL-4 signaling pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Cancer immunotherapy by CTLA4 blockade; Cancer immunotherapy by PD-1 blockade; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; Insulin signaling; IL-2 signaling pathway; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Orexin receptor pathway; GDNF signaling; Interferon type I signaling pathways; Type II interferon signaling; T-cell receptor signaling pathway" "PIP3 activates AKT signaling; GPVI-mediated activation cascade; SARS-CoV-2 activates/modulates innate and adaptive immune responses; PD-1 signaling; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Signal regulatory protein family interactions; Constitutive Signaling by Aberrant PI3K in Cancer; Interleukin-3, Interleukin-5 and GM-CSF signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; PI3K Cascade; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Signaling by CSF3 (G-CSF); GAB1 signalosome; Signaling by CSF1 (M-CSF) in myeloid cells; PI-3K cascade:FGFR1; FRS-mediated FGFR1 signaling; PI-3K cascade:FGFR2; FRS-mediated FGFR2 signaling; FRS-mediated FGFR3 signaling; PI-3K cascade:FGFR3; FRS-mediated FGFR4 signaling; PI-3K cascade:FGFR4; Activated NTRK2 signals through FRS2 and FRS3; Spry regulation of FGF signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; Interleukin-20 family signaling; Netrin mediated repulsion signals; Interleukin-37 signaling; Signaling by FLT3 ITD and TKD mutants; Platelet sensitization by LDL; PECAM1 interactions; CTLA4 inhibitory signaling; MET activates PTPN11; STAT5 activation downstream of FLT3 ITD mutants; Regulation of RUNX1 Expression and Activity; STAT5 Activation" "91" "0" "0.968" "0.993" "0.981" "0.974" "0.973" "0.895" "0.987" "1.026" "0.996" "1514.4" "1465.9" "1503.4" "1485.9" "1475.1" "1473.5" "1355.8" "1495.0" "1553.6" "1508.6" "" "" "" "" "" "" "" "" "" "" "1419.0" "1213.0" "1395.7" "1148.7" "1257.3" "1407.8" "1238.8" "1327.4" "1553.6" "1452.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8479423548841098522" "False" "High" "IsMasterProtein" "P21283" "V-type proton ATPase subunit C 1 OS=Homo sapiens OX=9606 GN=ATP6V1C1 PE=1 SV=4" "0.000" "False" "37.333" "37" "15" "22" "15" "382" "43.9" "7.46" "66.05" "15" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity" "Pf03223" "528" "ENSG00000155097" "ATP6V1C1" "hsa:528; P21283" "Proximal tubule transport" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "6" "0" "1.002" "1.007" "0.951" "1.026" "1.062" "0.954" "0.998" "1.016" "1.059" "1880.7" "1884.4" "1893.1" "1788.1" "1929.4" "1996.7" "1793.3" "1876.2" "1911.3" "1992.1" "" "" "" "" "" "" "" "" "" "" "1762.2" "1559.3" "1757.5" "1382.3" "1644.6" "1907.7" "1638.6" "1665.9" "1911.3" "1918.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602347345364685954" "False" "High" "IsMasterProtein" "P09429" "High mobility group protein B1 OS=Homo sapiens OX=9606 GN=HMGB1 PE=1 SV=3" "0.000" "False" "37.324" "27" "8" "26" "7" "215" "24.9" "5.74" "82.92" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "3146" "ENSG00000189403" "HMGB1" "A5D8W9; hsa:3146; P09429; Q14321; Q5T7C3; Q6IBE1" "Retinoblastoma gene in cancer; VEGFA-VEGFR2 signaling; Suppression of HMGB1-mediated inflammation by THBD; Base excision repair; DNA repair pathways, full network; Pleural mesothelioma; Clock-controlled autophagy in bone metabolism; Autophagy in pancreatic ductal adenocarcinoma; DNA damage response (only ATM dependent)" "ER-Phagosome pathway; Neutrophil degranulation; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Apoptosis induced DNA fragmentation; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation; Pyroptosis; Advanced glycosylation endproduct receptor signaling" "20" "0" "1.410" "1.144" "1.110" "1.095" "1.059" "0.952" "1.097" "1.293" "1.100" "1405.5" "1981.0" "1607.3" "1559.9" "1539.5" "1487.8" "1337.3" "1542.1" "1817.1" "1546.7" "" "" "" "" "" "" "" "" "" "" "1316.9" "1639.3" "1492.2" "1205.8" "1312.2" "1421.4" "1222.0" "1369.2" "1817.1" "1489.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4181332469245940194" "False" "High" "IsMasterProtein" "Q9UMR2" "ATP-dependent RNA helicase DDX19B OS=Homo sapiens OX=9606 GN=DDX19B PE=1 SV=1" "0.000" "False" "37.321" "25" "10" "17" "1" "479" "53.9" "6.30" "51.23" "10" "other metabolic processes;transport" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "11269" "ENSG00000157349" "DDX19B" "B3KNE9; B4DXS6; E7EMK4; hsa:11269; Q6FIB7; Q6IAE0; Q96KE7; Q9H0U0; Q9UMR2" "" "" "0" "0" "1.026" "0.836" "1.194" "0.998" "0.926" "1.149" "0.916" "0.916" "0.918" "28.1" "28.8" "23.5" "33.6" "28.0" "26.0" "32.3" "25.7" "25.7" "25.8" "" "" "" "" "" "" "" "" "" "" "26.3" "23.9" "21.8" "26.0" "23.9" "24.9" "29.5" "22.9" "25.7" "24.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1200242617848963307" "False" "High" "IsMasterProtein" "P31749" "RAC-alpha serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=AKT1 PE=1 SV=2" "0.000" "False" "37.305" "29" "14" "16" "11" "480" "55.7" "6.07" "39.86" "14" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00433" "207" "ENSG00000142208" "AKT1" "B2RAM5; B7Z5R1; hsa:207; P31749; Q9BWB6" "IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase signaling; Target of rapamycin signaling; Angiogenesis; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Apoptosis; Primary focal segmental glomerulosclerosis (FSGS); T cell receptor and co-stimulatory signaling; S1P receptor signal transduction; Cardiac hypertrophic response; Mammary gland development pathway - Embryonic development (Stage 1 of 4); IL-3 signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Extracellular vesicle-mediated signaling in recipient cells; Kit receptor signaling pathway; Focal adhesion; Copper homeostasis; RAC1/PAK1/p38/MMP2 pathway; Ovarian infertility; MECP2 and associated Rett syndrome; Wnt signaling pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Pathways affected in adenoid cystic carcinoma; Wnt/beta-catenin signaling pathway in leukemia; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Fibrin complement receptor 3 signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Endometrial cancer; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Caloric restriction and aging; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Neovascularization processes; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Endochondral ossification; Netrin-UNC5B signaling pathway; EGFR tyrosine kinase inhibitor resistance; Endochondral ossification with skeletal dysplasias; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; Kisspeptin/kisspeptin receptor system in the ovary; IL-2 signaling pathway; 3q29 copy number variation syndrome; Modulators of TCR signaling and T cell activation; Kallmann syndrome; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Opioid receptor pathways; CCL18 signaling pathway; Alzheimer's disease; GDNF signaling; Roles of ceramides in development of insulin resistance; Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Clock-controlled autophagy in bone metabolism; Warburg effect modulated by deubiquitinating enzymes and their substrates; Comprehensive IL-17A signaling; Acute myeloid leukemia; Sildenafil treatment; Primary ovarian insufficiency; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; JAK-STAT signaling in the regulation of beta cells; Osteoarthritic chondrocyte hypertrophy; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; Artemisinin inhibition of uveal melanoma; EPO receptor signaling; Notch signaling pathway; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response; Estrogen signaling pathway; Toll-like receptor signaling pathway" "Deactivation of the beta-catenin transactivating complex; TP53 Regulates Metabolic Genes; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Negative regulation of NOTCH4 signaling; RAB GEFs exchange GTP for GDP on RABs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; Regulation of TP53 Degradation; CD28 dependent PI3K/Akt signaling; Interleukin-4 and Interleukin-13 signaling; Downregulation of ERBB2:ERBB3 signaling; G beta:gamma signalling through PI3Kgamma; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; AKT phosphorylates targets in the cytosol; Regulation of TP53 Activity through Association with Co-factors; Integrin signaling; VEGFR2 mediated vascular permeability; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; MTOR signalling; FLT3 Signaling; eNOS activation; Regulation of TP53 Activity through Acetylation; KSRP (KHSRP) binds and destabilizes mRNA; RUNX2 regulates genes involved in cell migration; Cyclin E associated events during G1/S transition ; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Cyclin A:Cdk2-associated events at S phase entry; CTLA4 inhibitory signaling; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Activation of BAD and translocation to mitochondria ; AKT-mediated inactivation of FOXO1A; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "179" "2" "0.942" "0.984" "0.997" "1.010" "1.007" "0.923" "0.953" "0.959" "1.003" "1840.5" "1733.4" "1810.9" "1834.4" "1858.8" "1854.2" "1698.2" "1753.7" "1765.7" "1846.2" "" "" "" "" "" "" "" "" "" "" "1724.5" "1434.4" "1681.2" "1418.1" "1584.4" "1771.5" "1551.7" "1557.1" "1765.7" "1777.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7324571001266765675" "False" "High" "IsMasterProtein" "P29350" "Tyrosine-protein phosphatase non-receptor type 6 OS=Homo sapiens OX=9606 GN=PTPN6 PE=1 SV=1" "0.000" "False" "37.300" "24" "13" "15" "13" "595" "67.5" "7.78" "40.20" "13" "cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00017, Pf00102" "5777" "ENSG00000111679" "PTPN6" "A8K306; G3V0F8; hsa:5777; P29350; Q969V8; Q9UK67" "Prolactin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; IL-3 signaling pathway; Kit receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Cancer immunotherapy by CTLA4 blockade; Modulators of TCR signaling and T cell activation; Interferon type I signaling pathways" "Neutrophil degranulation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; PD-1 signaling; CD22 mediated BCR regulation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Signal regulatory protein family interactions; Interleukin receptor SHC signaling; GPVI-mediated activation cascade; Signaling by ALK; Regulation of KIT signaling; Growth hormone receptor signaling; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Interleukin-37 signaling; Platelet sensitization by LDL; PECAM1 interactions; Nuclear events stimulated by ALK signaling in cancer" "33" "0" "0.994" "1.018" "1.047" "1.045" "1.025" "1.053" "1.005" "0.997" "1.027" "1015.9" "1010.2" "1034.4" "1064.2" "1062.0" "1041.0" "1069.8" "1020.8" "1012.6" "1043.5" "" "" "" "" "" "" "" "" "" "" "951.9" "835.9" "960.3" "822.6" "905.3" "994.6" "977.5" "906.4" "1012.6" "1004.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7575182119282234217" "False" "High" "IsMasterProtein" "P18669" "Phosphoglycerate mutase 1 OS=Homo sapiens OX=9606 GN=PGAM1 PE=1 SV=2" "0.000" "False" "37.274" "46" "9" "31" "9" "254" "28.8" "7.18" "93.07" "9" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf00300" "5223" "ENSG00000171314" "PGAM1" "hsa:5223; P18669; Q9BWC0" "Cori cycle; Metabolic reprogramming in colon cancer; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Neutrophil degranulation; Glycolysis; Gluconeogenesis" "8" "0" "1.012" "1.031" "1.009" "0.966" "0.995" "0.939" "1.004" "0.977" "1.001" "2214.4" "2241.7" "2282.7" "2234.0" "2140.0" "2204.2" "2078.7" "2223.5" "2162.5" "2217.6" "" "" "" "" "" "" "" "" "" "" "2074.9" "1855.0" "2119.2" "1727.0" "1824.1" "2105.9" "1899.3" "1974.2" "2162.5" "2135.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5991678768207076864" "False" "High" "IsMasterProtein" "Q9UNF1" "Melanoma-associated antigen D2 OS=Homo sapiens OX=9606 GN=MAGED2 PE=1 SV=2" "0.000" "False" "37.252" "19" "13" "14" "13" "606" "64.9" "9.32" "47.16" "13" "transport;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01454" "10916" "ENSG00000102316" "MAGED2" "A6NMX0; hsa:10916; O76058; Q5BJF3; Q8NAL6; Q9H218; Q9P0U9; Q9UM52; Q9UNF1" "" "Platelet degranulation" "1" "0" "0.998" "0.970" "0.953" "0.981" "0.970" "0.902" "0.883" "0.913" "0.986" "3324.3" "3316.8" "3223.8" "3166.7" "3261.4" "3223.5" "2997.8" "2935.5" "3035.6" "3279.2" "" "" "" "" "" "" "" "" "" "" "3114.9" "2744.6" "2992.9" "2448.0" "2780.0" "3079.7" "2739.2" "2606.4" "3035.6" "3157.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8487408262660345487" "False" "High" "IsMasterProtein" "P11388" "DNA topoisomerase 2-alpha OS=Homo sapiens OX=9606 GN=TOP2A PE=1 SV=3" "0.000" "False" "37.244" "8" "13" "17" "7" "1531" "174.3" "8.72" "49.87" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00204, Pf00521, Pf01751, Pf02518, Pf08070, Pf16898" "7153" "ENSG00000131747" "TOP2A" "B2RTS1; hsa:7153; P11388; Q71UN1; Q71UQ5; Q9HB24; Q9HB25; Q9HB26; Q9UP44; Q9UQP9" "Gastric cancer network 1; Gastric cancer network 2; Retinoblastoma gene in cancer" "SUMOylation of DNA replication proteins; Transcription of E2F targets under negative control by DREAM complex" "5" "0" "0.970" "1.004" "1.088" "1.084" "1.011" "1.374" "1.486" "1.387" "1.162" "1027.1" "995.9" "1031.2" "1117.1" "1113.8" "1038.1" "1411.6" "1526.2" "1424.2" "1194.0" "" "" "" "" "" "" "" "" "" "" "962.4" "824.1" "957.3" "863.5" "949.3" "991.8" "1289.8" "1355.1" "1424.2" "1149.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7973813700341614243" "False" "High" "IsMasterProtein" "Q96SB4" "SRSF protein kinase 1 OS=Homo sapiens OX=9606 GN=SRPK1 PE=1 SV=2" "0.000" "False" "37.192" "17" "11" "13" "8" "655" "74.3" "6.16" "43.06" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6732" "ENSG00000096063" "SRPK1" "B4DS61; hsa:6732; Q12890; Q5R364; Q5R365; Q8IY12; Q96SB4" "VEGFA-VEGFR2 signaling; mRNA processing" "Replacement of protamines by nucleosomes in the male pronucleus; Maturation of nucleoprotein" "4" "3" "1.032" "1.086" "1.034" "1.006" "1.026" "1.045" "0.989" "1.018" "1.010" "1779.3" "1836.8" "1932.0" "1839.0" "1789.5" "1824.9" "1858.8" "1759.6" "1811.8" "1797.4" "" "" "" "" "" "" "" "" "" "" "1667.2" "1519.9" "1793.6" "1421.6" "1525.3" "1743.5" "1698.5" "1562.4" "1811.8" "1730.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5690407567518484702" "False" "High" "IsMasterProtein" "Q9HCS7" "Pre-mRNA-splicing factor SYF1 OS=Homo sapiens OX=9606 GN=XAB2 PE=1 SV=2" "0.000" "False" "37.152" "15" "14" "18" "14" "855" "99.9" "6.23" "48.38" "14" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes" "nucleus;other cell component" "" "Pf13181" "56949" "ENSG00000076924" "XAB2" "hsa:56949; Q8TET6; Q96HB0; Q96IW0; Q9HCS7; Q9NRG6; Q9ULP3" "Rett syndrome; Nucleotide excision repair in xeroderma pigmentosum" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "7" "0" "0.998" "0.978" "1.032" "1.033" "1.038" "1.060" "1.000" "1.061" "1.011" "893.9" "891.9" "874.5" "922.3" "923.1" "928.2" "947.4" "894.0" "948.2" "904.1" "" "" "" "" "" "" "" "" "" "" "837.6" "738.0" "811.9" "713.0" "786.8" "886.8" "865.7" "793.8" "948.2" "870.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3705631994362769923" "False" "High" "IsMasterProtein" "P11413" "Glucose-6-phosphate 1-dehydrogenase OS=Homo sapiens OX=9606 GN=G6PD PE=1 SV=4" "0.000" "False" "37.148" "24" "12" "16" "12" "515" "59.2" "6.84" "51.12" "12" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00479, Pf02781" "2539" "ENSG00000160211" "G6PD" "D3DWX9; hsa:2539; P11413; Q16000; Q16765; Q8IU70; Q8IU88; Q8IUA6; Q96PQ2" "Glutathione metabolism; Pentose phosphate metabolism; Cori cycle; Vitamin D receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; ATM signaling in development and disease ; Metabolic reprogramming in colon cancer; Vitamin D-sensitive calcium signaling in depression; Pentose phosphate pathway in senescent cells; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; Sulfation biotransformation reaction" "TP53 Regulates Metabolic Genes; NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway" "16" "0" "0.920" "0.998" "0.922" "0.955" "0.971" "0.911" "0.975" "0.965" "0.960" "2181.2" "2007.1" "2176.6" "2010.0" "2083.6" "2118.1" "1986.8" "2127.1" "2105.6" "2092.9" "" "" "" "" "" "" "" "" "" "" "2043.8" "1660.8" "2020.7" "1553.8" "1776.0" "2023.7" "1815.4" "1888.7" "2105.6" "2015.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1757040485264551221" "False" "High" "IsMasterProtein" "Q9Y6A5" "Transforming acidic coiled-coil-containing protein 3 OS=Homo sapiens OX=9606 GN=TACC3 PE=1 SV=1" "0.000" "False" "37.054" "17" "13" "15" "13" "838" "90.3" "5.05" "51.93" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf05010" "10460" "ENSG00000013810" "TACC3" "hsa:10460; Q2NKK4; Q3KQS5; Q9UMQ1; Q9Y6A5" "4p16.3 copy number variation" "NOTCH3 Activation and Transmission of Signal to the Nucleus; Negative regulation of NOTCH4 signaling" "3" "0" "1.016" "0.945" "0.942" "0.965" "0.995" "0.898" "0.896" "0.899" "0.947" "2063.8" "2097.8" "1949.3" "1943.7" "1991.2" "2054.0" "1852.6" "1848.3" "1854.6" "1953.9" "" "" "" "" "" "" "" "" "" "" "1933.7" "1735.9" "1809.7" "1502.5" "1697.2" "1962.4" "1692.7" "1641.1" "1854.6" "1881.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8210818149912646419" "False" "High" "IsMasterProtein" "P11216" "Glycogen phosphorylase, brain form OS=Homo sapiens OX=9606 GN=PYGB PE=1 SV=5" "0.000" "False" "37.005" "16" "14" "17" "14" "843" "96.6" "6.86" "54.98" "14" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00343" "5834" "ENSG00000100994" "PYGB" "hsa:5834; P11216; Q96AK1; Q9NPX8" "IL-18 signaling pathway; Glycogen synthesis and degradation" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis)" "4" "0" "0.951" "0.949" "1.034" "0.952" "0.970" "0.959" "0.995" "0.957" "0.966" "1176.4" "1118.3" "1116.2" "1216.0" "1120.1" "1141.3" "1128.5" "1170.3" "1125.5" "1136.9" "" "" "" "" "" "" "" "" "" "" "1102.3" "925.4" "1036.3" "940.0" "954.8" "1090.4" "1031.2" "1039.1" "1125.5" "1094.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3834517730795482410" "False" "High" "IsMasterProtein" "Q05655" "Protein kinase C delta type OS=Homo sapiens OX=9606 GN=PRKCD PE=1 SV=2" "0.000" "False" "36.989" "20" "14" "18" "14" "676" "77.5" "7.75" "53.84" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00130, Pf00433, Pf21494" "5580" "ENSG00000163932" "PRKCD" "B0KZ81; B2R834; hsa:5580; Q05655; Q15144; Q86XJ6" "Type II diabetes mellitus; Glioblastoma signaling pathways; B cell receptor signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; IL6 signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Wnt signaling pathway and pluripotency; Pancreatic adenocarcinoma pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Galanin receptor pathway; Orexin receptor pathway; CCL18 signaling pathway; Chronic hyperglycemia impairment of neuron function; TROP2 regulatory signaling; Calcium regulation in cardiac cells; Type II interferon signaling; T-cell receptor signaling pathway" "Neutrophil degranulation; CLEC7A (Dectin-1) signaling; KEAP1-NFE2L2 pathway; Role of phospholipids in phagocytosis; G alpha (z) signalling events; Interferon gamma signaling; SHC1 events in ERBB2 signaling; HuR (ELAVL1) binds and stabilizes mRNA; VEGFR2 mediated cell proliferation; DAG and IP3 signaling; Effects of PIP2 hydrolysis; RHO GTPases Activate NADPH Oxidases; Calmodulin induced events; Apoptotic cleavage of cellular proteins" "47" "0" "0.936" "0.976" "0.906" "0.959" "0.977" "0.847" "0.872" "0.862" "0.922" "2937.8" "2748.6" "2866.9" "2661.5" "2817.5" "2870.1" "2489.5" "2563.2" "2533.6" "2710.0" "" "" "" "" "" "" "" "" "" "" "2752.7" "2274.4" "2661.5" "2057.5" "2401.5" "2742.2" "2274.8" "2275.9" "2533.6" "2609.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3284671458686948130" "False" "High" "IsMasterProtein" "Q14498" "RNA-binding protein 39 OS=Homo sapiens OX=9606 GN=RBM39 PE=1 SV=2" "0.000" "False" "36.932" "18" "8" "15" "8" "530" "59.3" "10.10" "47.81" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00076, Pf15519" "9584" "ENSG00000131051" "RBM39" "A2RRD3; A5D8W2; B0BLV3; E1P5S0; E1P5S1; hsa:9584; Q14498; Q14499" "VEGFA-VEGFR2 signaling; mRNA processing" "mRNA Splicing - Major Pathway" "3" "0" "1.183" "1.160" "1.105" "1.052" "1.059" "0.998" "0.971" "1.042" "1.101" "570.8" "675.6" "662.0" "630.9" "600.4" "604.3" "569.7" "554.3" "594.7" "628.7" "" "" "" "" "" "" "" "" "" "" "534.9" "559.0" "614.6" "487.7" "511.7" "577.3" "520.5" "492.2" "594.7" "605.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8242626749563967556" "False" "High" "IsMasterProtein" "Q9Y606" "Pseudouridylate synthase 1 homolog OS=Homo sapiens OX=9606 GN=PUS1 PE=1 SV=3" "0.000" "False" "36.916" "27" "11" "18" "11" "427" "47.4" "8.41" "49.11" "11" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01416" "80324" "ENSG00000177192" "PUS1" "A8K877; B3KQC1; hsa:80324; Q8WYT2; Q9BU44; Q9Y606" "" "" "0" "0" "0.961" "0.977" "0.982" "0.956" "0.967" "0.942" "0.953" "1.032" "0.972" "1315.1" "1263.8" "1284.8" "1291.9" "1256.9" "1271.9" "1238.9" "1253.1" "1357.0" "1277.7" "" "" "" "" "" "" "" "" "" "" "1232.2" "1045.7" "1192.8" "998.7" "1071.3" "1215.2" "1132.0" "1112.7" "1357.0" "1230.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7577661902964436810" "False" "High" "IsMasterProtein" "Q3LXA3" "Triokinase/FMN cyclase OS=Homo sapiens OX=9606 GN=TKFC PE=1 SV=2" "0.000" "False" "36.851" "20" "10" "16" "10" "575" "58.9" "7.49" "45.92" "10" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf02733, Pf02734" "26007" "ENSG00000149476" "TKFC" "hsa:26007; Q2L9C1; Q3LXA3; Q53EQ9; Q9BVA7; Q9H895" "Novel intracellular components of RIG-I-like receptor pathway" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; DDX58/IFIH1-mediated induction of interferon-alpha/beta; SARS-CoV-1 activates/modulates innate immune responses; Fructose catabolism" "5" "0" "0.979" "0.952" "0.967" "0.946" "0.948" "0.932" "0.915" "0.949" "0.945" "1528.7" "1496.2" "1454.8" "1478.0" "1446.6" "1449.3" "1424.6" "1399.5" "1450.8" "1445.2" "" "" "" "" "" "" "" "" "" "" "1432.4" "1238.1" "1350.6" "1142.5" "1233.1" "1384.6" "1301.7" "1242.6" "1450.8" "1391.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4988285782465549683" "False" "High" "IsMasterProtein" "Q9NYB0" "Telomeric repeat-binding factor 2-interacting protein 1 OS=Homo sapiens OX=9606 GN=TERF2IP PE=1 SV=1" "0.000" "False" "36.796" "29" "10" "13" "10" "399" "44.2" "4.73" "46.74" "10" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08914, Pf11626, Pf16589" "54386" "ENSG00000166848" "TERF2IP" "B4DQN4; hsa:54386; Q4W4Y2; Q8WYZ3; Q9NWR2; Q9NYB0" "Splicing factor NOVA regulated synaptic proteins; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "DNA Damage/Telomere Stress Induced Senescence; Meiotic synapsis; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Telomere Extension By Telomerase; Removal of the Flap Intermediate from the C-strand" "16" "0" "1.083" "1.022" "0.957" "1.014" "1.057" "1.011" "1.067" "1.063" "1.021" "2164.7" "2345.2" "2212.4" "2071.2" "2195.0" "2288.4" "2187.8" "2310.1" "2302.1" "2210.8" "" "" "" "" "" "" "" "" "" "" "2028.4" "1940.6" "2053.9" "1601.1" "1871.0" "2186.3" "1999.1" "2051.1" "2302.1" "2128.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7512060777885112035" "False" "High" "IsMasterProtein" "P63244" "Small ribosomal subunit protein RACK1 OS=Homo sapiens OX=9606 GN=RACK1 PE=1 SV=3" "0.000" "False" "36.748" "32" "10" "19" "10" "317" "35.1" "7.69" "63.38" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;cytosol;mitochondrion;translational apparatus;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;translation activity;other molecular function" "Pf00400" "10399" "ENSG00000204628" "RACK1" "B3KTJ0; D3DWS0; hsa:10399; P25388; P63244; P99049; Q53HU2; Q5J8M6; Q5VLR4; Q6FH47" "Androgen receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; Measles virus infection; Angiotensin II receptor type 1 pathway; TROP2 regulatory signaling; Interferon type I signaling pathways" "Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-mediated ceramide production" "10" "0" "1.045" "1.070" "1.064" "1.079" "1.086" "1.233" "1.250" "1.198" "1.081" "2161.9" "2258.7" "2312.5" "2301.3" "2333.6" "2347.1" "2666.4" "2702.2" "2589.4" "2336.1" "" "" "" "" "" "" "" "" "" "" "2025.7" "1869.1" "2146.8" "1779.0" "1989.1" "2242.4" "2436.4" "2399.3" "2589.4" "2249.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2666399162137355267" "False" "High" "IsMasterProtein" "P38117" "Electron transfer flavoprotein subunit beta OS=Homo sapiens OX=9606 GN=ETFB PE=1 SV=3" "0.000" "False" "36.715" "50" "12" "22" "12" "255" "27.8" "8.10" "71.67" "12" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01012" "2109" "ENSG00000105379" "ETFB" "A8K766; B3KNY2; hsa:2109; P38117; Q6IBH7; Q71RF6; Q9Y3S7" "" "Respiratory electron transport; Protein methylation" "2" "0" "0.944" "0.979" "0.961" "0.951" "0.971" "0.922" "0.960" "0.916" "0.934" "2658.7" "2509.9" "2602.2" "2554.2" "2527.3" "2582.2" "2450.7" "2551.1" "2435.1" "2482.5" "" "" "" "" "" "" "" "" "" "" "2491.2" "2076.9" "2415.8" "1974.5" "2154.2" "2467.1" "2239.3" "2265.1" "2435.1" "2390.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7210504404319708374" "False" "High" "IsMasterProtein" "P33240" "Cleavage stimulation factor subunit 2 OS=Homo sapiens OX=9606 GN=CSTF2 PE=1 SV=1" "0.000" "False" "36.692" "24" "11" "15" "7" "577" "60.9" "6.83" "49.45" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf14304, Pf14327" "1478" "ENSG00000101811" "CSTF2" "hsa:1478; P33240; Q5H951; Q6LA74; Q8N502" "mRNA processing" "tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "6" "3" "1.057" "1.016" "1.126" "1.102" "1.080" "1.218" "1.235" "1.183" "1.061" "1236.3" "1306.8" "1256.2" "1392.3" "1361.9" "1335.6" "1505.3" "1526.9" "1462.4" "1311.8" "" "" "" "" "" "" "" "" "" "" "1158.4" "1081.4" "1166.3" "1076.3" "1160.9" "1276.1" "1375.4" "1355.7" "1462.4" "1263.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5219962160653880547" "False" "High" "IsMasterProtein" "Q15785" "Mitochondrial import receptor subunit TOM34 OS=Homo sapiens OX=9606 GN=TOMM34 PE=1 SV=2" "0.000" "False" "36.582" "41" "11" "15" "11" "309" "34.5" "8.98" "54.94" "11" "other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00515" "10953" "ENSG00000025772" "TOMM34" "hsa:10953; Q15785; Q53GH9; Q6IBN7; Q9NTZ3" "" "" "0" "0" "0.974" "1.009" "0.986" "0.999" "1.008" "0.973" "0.981" "0.965" "0.994" "2925.7" "2848.7" "2951.8" "2885.1" "2921.5" "2948.9" "2847.3" "2870.9" "2821.9" "2907.3" "" "" "" "" "" "" "" "" "" "" "2741.3" "2357.3" "2740.4" "2230.3" "2490.2" "2817.4" "2601.6" "2549.1" "2821.9" "2799.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8528417393103392868" "False" "High" "IsMasterProtein" "Q9BQ04" "RNA-binding protein 4B OS=Homo sapiens OX=9606 GN=RBM4B PE=1 SV=1" "0.000" "False" "36.579" "40" "13" "18" "2" "359" "40.1" "6.74" "50.26" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00076, Pf00098" "83759" "ENSG00000173914" "RBM4B" "B3KT83; hsa:83759; Q9BQ04" "" "" "0" "6" "0.956" "0.982" "0.929" "0.981" "0.995" "0.876" "0.927" "0.912" "0.960" "1934.8" "1849.2" "1900.8" "1797.0" "1898.8" "1924.9" "1695.6" "1793.9" "1764.3" "1857.8" "" "" "" "" "" "" "" "" "" "" "1812.9" "1530.2" "1764.6" "1389.2" "1618.5" "1839.0" "1549.3" "1592.8" "1764.3" "1788.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-629472087456424791" "False" "High" "IsMasterProtein" "Q09472" "Histone acetyltransferase p300 OS=Homo sapiens OX=9606 GN=EP300 PE=1 SV=2" "0.000" "False" "36.567" "5" "14" "19" "7" "2414" "264.0" "8.50" "54.74" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00439, Pf00569, Pf02135, Pf02172, Pf06001, Pf08214, Pf09030" "2033" "ENSG00000100393" "EP300" "B1AKC2; hsa:2033; Q09472" "Androgen receptor signaling pathway; Energy metabolism; Cell cycle; Glioblastoma signaling pathways; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; IL-4 signaling pathway; Wnt signaling pathway and pluripotency; Prion disease pathway; Clear cell renal cell carcinoma pathways; Ebola virus infection in host; Type 2 papillary renal cell carcinoma; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; CAMKK2 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; CCL18 signaling pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis; Urotensin-II-mediated signaling pathway; Pathophysiological roles of DUX4 in FSHD1; HDAC6 interactions in the central nervous system; TGF-beta receptor signaling; Notch signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "Regulation of RUNX3 expression and activity; Heme signaling; STAT3 nuclear events downstream of ALK signaling; Attenuation phase; Zygotic genome activation (ZGA); PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NGF-stimulated transcription; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; SUMOylation of transcription cofactors; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Metalloprotease DUBs; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of TP53 Activity through Methylation; NFE2L2 regulating anti-oxidant/detoxification enzymes; HATs acetylate histones; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; NOTCH1 Intracellular Domain Regulates Transcription; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NFE2L2 regulating MDR associated enzymes; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Nuclear events mediated by NFE2L2; NFE2L2 regulates pentose phosphate pathway genes; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; NOTCH3 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NFE2L2 regulating inflammation associated genes; NFE2L2 regulating tumorigenic genes; NFE2L2 regulating ER-stress associated genes; Regulation of NFE2L2 gene expression; Transcriptional regulation of granulopoiesis; RORA activates gene expression; CD209 (DC-SIGN) signaling; Polo-like kinase mediated events; Activation of the TFAP2 (AP-2) family of transcription factors; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; RUNX3 regulates p14-ARF; Regulation of gene expression by Hypoxia-inducible Factor; PI5P Regulates TP53 Acetylation; NOTCH2 intracellular domain regulates transcription; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "91" "0" "1.023" "0.950" "0.894" "1.021" "0.906" "0.902" "0.987" "0.991" "0.961" "414.9" "424.3" "394.1" "371.0" "423.8" "376.1" "374.1" "409.7" "411.4" "398.6" "" "" "" "" "" "" "" "" "" "" "388.8" "351.1" "365.9" "286.8" "361.2" "359.3" "341.8" "363.7" "411.4" "383.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4457645785715096452" "False" "High" "IsMasterProtein" "Q9BS26" "Endoplasmic reticulum resident protein 44 OS=Homo sapiens OX=9606 GN=ERP44 PE=1 SV=1" "0.000" "False" "36.546" "31" "12" "16" "11" "406" "46.9" "5.26" "47.51" "12" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00085, Pf13848" "23071" "ENSG00000023318" "ERP44" "hsa:23071; O60319; Q4VXC1; Q5VWZ7; Q6UW14; Q8WX67; Q9BS26" "" "Neutrophil degranulation" "1" "1" "0.954" "0.970" "0.957" "0.970" "0.990" "0.923" "1.002" "0.931" "0.963" "2182.4" "2082.8" "2117.1" "2089.5" "2116.6" "2161.5" "2013.6" "2186.6" "2031.5" "2102.5" "" "" "" "" "" "" "" "" "" "" "2044.9" "1723.5" "1965.4" "1615.3" "1804.2" "2065.1" "1839.9" "1941.5" "2031.5" "2024.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4723246947420564514" "False" "High" "IsMasterProtein" "O94915" "Protein furry homolog-like OS=Homo sapiens OX=9606 GN=FRYL PE=1 SV=2" "0.000" "False" "36.498" "4" "16" "18" "15" "3013" "339.4" "5.58" "46.79" "16" "cell organization and biogenesis;developmental processes;other biological processes" "other cell component" "" "Pf14222, Pf14225, Pf14228, Pf19421" "285527" "ENSG00000075539" "FRYL" "hsa:285527; O94915; O95640; Q8WTZ5; Q9NT40" "" "" "0" "0" "0.955" "0.935" "0.958" "0.915" "0.910" "0.904" "0.853" "0.898" "0.968" "925.0" "883.2" "864.6" "886.4" "846.1" "842.1" "836.0" "788.6" "830.4" "895.7" "" "" "" "" "" "" "" "" "" "" "866.7" "730.8" "802.7" "685.2" "721.2" "804.5" "763.9" "700.2" "830.4" "862.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8444524107574200916" "False" "High" "IsMasterProtein" "Q9UH73" "Transcription factor COE1 OS=Homo sapiens OX=9606 GN=EBF1 PE=1 SV=2" "0.000" "False" "36.470" "21" "11" "13" "11" "591" "64.4" "8.76" "41.33" "11" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01833, Pf16422, Pf16423" "1879" "ENSG00000164330" "EBF1" "hsa:1879; Q8IW11; Q9UH73" "Adipogenesis; Prion disease pathway; White fat cell differentiation" "Transcriptional regulation of white adipocyte differentiation; Expression and translocation of olfactory receptors" "5" "0" "1.006" "0.959" "0.954" "1.048" "1.028" "0.968" "0.986" "1.019" "1.006" "1157.9" "1164.3" "1110.4" "1104.5" "1213.2" "1190.8" "1120.7" "1141.5" "1179.3" "1164.7" "" "" "" "" "" "" "" "" "" "" "1084.9" "963.4" "1030.9" "853.9" "1034.1" "1137.7" "1024.1" "1013.6" "1179.3" "1121.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1597744866915900932" "False" "High" "IsMasterProtein" "P51114" "RNA-binding protein FXR1 OS=Homo sapiens OX=9606 GN=FXR1 PE=1 SV=3" "0.000" "False" "36.446" "18" "11" "14" "9" "621" "69.7" "6.15" "50.07" "11" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16096, Pf16097, Pf17904, Pf18336" "8087" "ENSG00000114416" "FXR1" "A8K9B8; hsa:8087; P51114; Q7Z450; Q8N6R8" "Bile acids synthesis and enterohepatic circulation" "Signaling by BRAF and RAF1 fusions" "2" "2" "0.976" "1.039" "1.030" "1.037" "1.081" "1.077" "1.049" "1.099" "1.031" "2148.7" "2097.2" "2233.2" "2213.4" "2227.8" "2323.4" "2313.7" "2254.4" "2362.1" "2215.3" "" "" "" "" "" "" "" "" "" "" "2013.3" "1735.4" "2073.2" "1711.0" "1899.0" "2219.8" "2114.1" "2001.7" "2362.1" "2133.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6750207652327358618" "False" "High" "IsMasterProtein" "O43719" "17S U2 SnRNP complex component HTATSF1 OS=Homo sapiens OX=9606 GN=HTATSF1 PE=1 SV=1" "0.000" "False" "36.435" "18" "15" "16" "15" "755" "85.8" "4.40" "45.22" "15" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00076" "27336" "ENSG00000102241" "HTATSF1" "D3DWG9; hsa:27336; O43719; Q59G06; Q99730" "" "mRNA Splicing - Major Pathway" "1" "0" "0.947" "1.012" "0.862" "0.857" "0.815" "0.879" "0.802" "0.815" "0.909" "2354.6" "2228.8" "2383.1" "2030.5" "2017.8" "1917.9" "2068.5" "1888.4" "1918.6" "2141.3" "" "" "" "" "" "" "" "" "" "" "2206.2" "1844.3" "2212.4" "1569.7" "1719.9" "1832.3" "1890.1" "1676.7" "1918.6" "2061.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8559290960834017297" "False" "High" "IsMasterProtein" "O14976" "Cyclin-G-associated kinase OS=Homo sapiens OX=9606 GN=GAK PE=1 SV=2" "0.000" "False" "36.425" "10" "12" "13" "12" "1311" "143.1" "5.73" "41.46" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf10409" "2580" "ENSG00000178950" "GAK" "hsa:2580; O14976; Q5U4P5; Q9BVY6" "" "Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis" "2" "0" "1.049" "1.023" "1.000" "1.072" "1.161" "0.931" "1.033" "1.032" "1.092" "794.4" "833.5" "812.7" "794.4" "851.7" "922.1" "739.5" "820.4" "820.0" "867.4" "" "" "" "" "" "" "" "" "" "" "744.4" "689.7" "754.5" "614.1" "725.9" "881.0" "675.7" "728.4" "820.0" "835.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "866424040394030727" "False" "High" "IsMasterProtein" "Q15052" "Rho guanine nucleotide exchange factor 6 OS=Homo sapiens OX=9606 GN=ARHGEF6 PE=1 SV=2" "0.000" "False" "36.398" "15" "12" "16" "11" "776" "87.4" "6.05" "43.83" "12" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00169, Pf00307, Pf00621, Pf07653, Pf16523, Pf16614, Pf16615" "9459" "ENSG00000129675" "ARHGEF6" "A6NMW9; A8K6S7; B1AL37; hsa:9459; Q15052; Q15396; Q5JQ66; Q7Z3W1; Q86XH0" "Pancreatic adenocarcinoma pathway; Regulation of actin cytoskeleton" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOU GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; G beta:gamma signalling through CDC42; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "9" "0" "1.023" "1.010" "1.014" "1.015" "1.001" "0.968" "0.951" "0.904" "1.001" "1615.4" "1651.9" "1632.3" "1638.7" "1639.8" "1617.8" "1563.2" "1536.3" "1461.1" "1616.7" "" "" "" "" "" "" "" "" "" "" "1513.6" "1366.9" "1515.4" "1266.8" "1397.7" "1545.7" "1428.3" "1364.1" "1461.1" "1556.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7031077161766424227" "False" "High" "IsMasterProtein" "Q4V328" "GRIP1-associated protein 1 OS=Homo sapiens OX=9606 GN=GRIPAP1 PE=1 SV=2" "0.000" "False" "36.376" "13" "12" "14" "12" "841" "95.9" "5.11" "42.98" "12" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "" "56850" "ENSG00000068400; ENSG00000292219" "GRIPAP1" "A6NL78; hsa:56850; Q3MJ75; Q4V327; Q4V328; Q4V330; Q5HYG1; Q6N046; Q96DH8; Q9NQ43; Q9ULQ3" "" "" "0" "0" "1.080" "0.984" "1.090" "1.077" "1.110" "0.977" "0.978" "1.002" "1.047" "1447.9" "1564.3" "1425.4" "1579.0" "1559.9" "1607.2" "1414.6" "1415.8" "1450.6" "1516.1" "" "" "" "" "" "" "" "" "" "" "1356.7" "1294.4" "1323.3" "1220.6" "1329.7" "1535.6" "1292.6" "1257.1" "1450.6" "1459.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4038126070754837566" "False" "High" "IsMasterProtein" "Cont_Q3SYV4" "Adenylyl cyclase-associated protein 1 OS=Bos taurus OX=9913 GN=CAP1 PE=2 SV=3" "0.000" "True" "36.370" "25" "9" "27" "2" "472" "51.2" "7.52" "67.07" "9" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "cytoskeletal activity;other molecular function" "Pf01213, Pf08603" "109556455; 504519" "" "CAP1" "A0A6P5BIK1; biu:109556455; bta:504519; Q3SYV4" "" "" "0" "0" "1.071" "1.053" "0.980" "1.060" "1.074" "1.022" "1.096" "1.056" "1.063" "262.0" "280.5" "275.8" "256.8" "277.7" "281.3" "267.7" "287.2" "276.5" "278.4" "" "" "" "" "" "" "" "" "" "" "245.5" "232.1" "256.0" "198.5" "236.7" "268.8" "244.6" "255.0" "276.5" "268.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5526079506929447963" "False" "High" "IsMasterProtein" "O14617" "AP-3 complex subunit delta-1 OS=Homo sapiens OX=9606 GN=AP3D1 PE=1 SV=1" "0.000" "False" "36.356" "12" "13" "14" "13" "1153" "130.1" "8.48" "39.41" "13" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01602, Pf06375" "8943" "ENSG00000065000" "AP3D1" "O00202; O14617; O75262; Q59HF5; Q96G11; Q9H3C6" "" "" "0" "0" "1.037" "1.063" "1.054" "1.054" "0.974" "1.024" "0.968" "0.988" "0.994" "485.2" "503.2" "515.9" "511.5" "511.4" "472.5" "497.0" "469.8" "479.4" "482.0" "" "" "" "" "" "" "" "" "" "" "454.6" "416.4" "479.0" "395.4" "435.9" "451.4" "454.1" "417.1" "479.4" "464.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8396121455567897427" "False" "High" "IsMasterProtein" "Q9Y4K1" "Beta/gamma crystallin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CRYBG1 PE=1 SV=4" "0.000" "False" "36.352" "6" "11" "13" "11" "2131" "231.6" "5.81" "45.76" "11" "" "" "other molecular function" "Pf00030, Pf00652" "" "ENSG00000112297" "CRYBG1" "A0A0J9YWL0" "" "" "0" "0" "0.995" "1.035" "1.079" "1.082" "1.035" "1.107" "1.058" "1.046" "1.063" "1587.9" "1580.1" "1643.3" "1713.4" "1718.3" "1643.8" "1757.4" "1679.4" "1660.9" "1688.6" "" "" "" "" "" "" "" "" "" "" "1487.8" "1307.5" "1525.6" "1324.5" "1464.7" "1570.5" "1605.8" "1491.2" "1660.9" "1625.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-355239685975103350" "False" "High" "IsMasterProtein" "O14578" "Citron Rho-interacting kinase OS=Homo sapiens OX=9606 GN=CIT PE=1 SV=2" "0.000" "False" "36.329" "6" "14" "15" "14" "2027" "231.3" "6.57" "41.24" "14" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;other biological processes" "cytosol" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00433, Pf00780" "11113" "ENSG00000122966" "CIT" "hsa:11113; O14578; Q2M5E1; Q6XUH8; Q86UQ9; Q9UPZ7" "Pleural mesothelioma; G13 signaling pathway" "RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RHO GTPases activate CIT" "7" "0" "1.042" "1.055" "1.149" "1.134" "1.138" "1.173" "1.143" "1.138" "1.111" "844.2" "879.7" "890.7" "970.3" "957.0" "960.3" "989.9" "964.9" "961.0" "937.6" "" "" "" "" "" "" "" "" "" "" "791.0" "727.9" "826.9" "750.1" "815.8" "917.4" "904.5" "856.8" "961.0" "902.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-91982353768306611" "False" "High" "IsMasterProtein" "P00492" "Hypoxanthine-guanine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=HPRT1 PE=1 SV=2" "0.000" "False" "36.247" "48" "9" "19" "9" "218" "24.6" "6.68" "52.82" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00156" "3251" "ENSG00000165704" "HPRT1" "A6NHF0; B2R8M9; hsa:3251; P00492" "Mesodermal commitment pathway" "Azathioprine ADME; Purine salvage; Defective HPRT1 disrupts guanine and hypoxanthine salvage" "4" "0" "0.943" "0.965" "0.952" "0.946" "0.940" "0.874" "0.943" "1.020" "0.942" "2119.1" "1998.2" "2045.1" "2018.2" "2004.6" "1992.1" "1853.1" "1998.7" "2160.9" "1996.5" "" "" "" "" "" "" "" "" "" "" "1985.6" "1653.5" "1898.6" "1560.2" "1708.7" "1903.3" "1693.3" "1774.7" "2160.9" "1922.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7312941423538826307" "False" "High" "IsMasterProtein" "P31350" "Ribonucleoside-diphosphate reductase subunit M2 OS=Homo sapiens OX=9606 GN=RRM2 PE=1 SV=1" "0.000" "False" "36.175" "34" "12" "16" "10" "389" "44.8" "5.38" "46.95" "12" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00268" "6241" "ENSG00000171848" "RRM2" "B2R9B5; hsa:6241; J3KP43; P31350; Q5WRU7" "Fluoropyrimidine activity; Retinoblastoma gene in cancer; Hepatitis C and hepatocellular carcinoma; Pyrimidine metabolism; Orexin receptor pathway" "Transcriptional Regulation by E2F6; Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription" "8" "2" "0.999" "1.012" "0.982" "1.016" "1.029" "0.946" "0.938" "0.948" "0.965" "2318.4" "2316.9" "2346.4" "2275.6" "2356.3" "2385.8" "2193.4" "2175.1" "2197.1" "2237.0" "" "" "" "" "" "" "" "" "" "" "2172.4" "1917.2" "2178.4" "1759.2" "2008.5" "2279.4" "2004.2" "1931.3" "2197.1" "2153.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "513337833647549896" "False" "High" "IsMasterProtein" "P11717" "Cation-independent mannose-6-phosphate receptor OS=Homo sapiens OX=9606 GN=IGF2R PE=1 SV=3" "0.000" "False" "36.136" "5" "12" "15" "12" "2491" "274.2" "5.94" "41.04" "12" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00040, Pf00878" "3482" "ENSG00000197081" "IGF2R" "hsa:3482; P11717; Q7Z7G9; Q96PT5" "TROP2 regulatory signaling" "Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network" "6" "0" "1.033" "0.994" "1.002" "1.012" "1.025" "1.059" "0.960" "1.062" "1.042" "805.6" "832.3" "800.9" "807.0" "815.4" "825.5" "852.7" "773.7" "855.3" "839.2" "" "" "" "" "" "" "" "" "" "" "754.8" "688.7" "743.5" "623.9" "695.0" "788.7" "779.2" "687.0" "855.3" "808.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-504997331308259812" "False" "High" "IsMasterProtein" "P17174" "Aspartate aminotransferase, cytoplasmic OS=Homo sapiens OX=9606 GN=GOT1 PE=1 SV=3" "0.000" "False" "36.122" "25" "10" "19" "10" "413" "46.2" "7.01" "65.27" "10" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00155" "2805" "ENSG00000120053" "GOT1" "B2R6R7; B7Z7E9; hsa:2805; P17174; Q5VW80" "Alanine and aspartate metabolism; Trans-sulfuration pathway; Amino acid metabolism; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; TCA cycle in senescence; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Gluconeogenesis; Aspartate and asparagine metabolism; Methionine salvage pathway" "11" "0" "0.982" "0.987" "0.981" "0.960" "0.994" "1.008" "0.923" "0.899" "0.913" "2141.4" "2102.0" "2113.5" "2100.6" "2054.7" "2128.1" "2158.7" "1976.4" "1924.9" "1956.1" "" "" "" "" "" "" "" "" "" "" "2006.5" "1739.4" "1962.1" "1623.9" "1751.4" "2033.2" "1972.5" "1754.9" "1924.9" "1883.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2546736599525709996" "False" "High" "IsMasterProtein" "Q8N1G2" "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=CMTR1 PE=1 SV=1" "0.000" "False" "36.085" "16" "15" "18" "15" "835" "95.3" "7.05" "45.50" "15" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01585, Pf01728" "23070" "ENSG00000137200" "CMTR1" "A8K949; hsa:23070; Q14670; Q8N1G2; Q96FJ9" "" "" "0" "0" "1.014" "1.010" "1.033" "1.031" "1.040" "1.023" "1.039" "1.042" "1.063" "1920.6" "1946.8" "1940.5" "1983.3" "1980.4" "1998.1" "1964.1" "1995.1" "2001.9" "2040.7" "" "" "" "" "" "" "" "" "" "" "1799.6" "1611.0" "1801.5" "1533.2" "1688.0" "1909.0" "1794.7" "1771.5" "2001.9" "1964.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6669951735420197648" "False" "High" "IsMasterProtein" "O00154" "Cytosolic acyl coenzyme A thioester hydrolase OS=Homo sapiens OX=9606 GN=ACOT7 PE=1 SV=3" "0.000" "False" "36.031" "31" "10" "20" "10" "380" "41.8" "8.54" "57.52" "10" "other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf03061" "11332" "ENSG00000097021" "ACOT7" "A8K0K7; A8K232; A8K6B8; A8K837; B3KQ12; hsa:11332; O00154; O43703; Q53Y78; Q5JYL2; Q5JYL3; Q5JYL4; Q5JYL5; Q5JYL6; Q5TGR4; Q9UJM9; Q9Y539; Q9Y540" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "0.992" "0.981" "0.989" "0.963" "0.956" "0.996" "0.939" "0.971" "0.984" "1610.3" "1597.0" "1579.6" "1592.1" "1550.1" "1539.4" "1603.9" "1512.2" "1564.1" "1583.8" "" "" "" "" "" "" "" "" "" "" "1508.8" "1321.5" "1466.5" "1230.7" "1321.2" "1470.7" "1465.6" "1342.7" "1564.1" "1525.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-154777414140805672" "False" "High" "IsMasterProtein" "P20810" "Calpastatin OS=Homo sapiens OX=9606 GN=CAST PE=1 SV=4" "0.000" "False" "36.021" "18" "12" "16" "12" "708" "76.5" "5.07" "55.15" "12" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00748" "831" "ENSG00000153113" "CAST" "B7Z468; G5E946; G5E9D3; hsa:831; O95360; P20810; Q05DE8; Q7Z4K0; Q96D08; Q9H1Z5" "" "Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "2" "0" "1.099" "0.978" "1.032" "1.004" "1.016" "1.057" "1.004" "0.949" "1.040" "1827.0" "2008.6" "1785.9" "1886.1" "1833.5" "1855.9" "1930.4" "1834.4" "1733.3" "1899.7" "" "" "" "" "" "" "" "" "" "" "1711.9" "1662.1" "1658.0" "1458.1" "1562.8" "1773.2" "1763.9" "1628.7" "1733.3" "1829.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7629412907813045008" "False" "High" "IsMasterProtein" "Q14997" "Proteasome activator complex subunit 4 OS=Homo sapiens OX=9606 GN=PSME4 PE=1 SV=2" "0.000" "False" "35.977" "7" "13" "13" "13" "1843" "211.2" "6.90" "41.31" "13" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf11919, Pf16507" "23198" "ENSG00000068878" "PSME4" "hsa:23198; Q14997; Q1XBG4; Q1XBG5; Q1XBG6; Q2M1Z0; Q6IPR2; Q86XF8" "" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway" "52" "0" "0.961" "0.996" "1.034" "1.016" "1.012" "1.007" "0.987" "0.941" "0.990" "1562.5" "1502.3" "1556.8" "1616.0" "1587.5" "1581.3" "1574.1" "1541.9" "1469.8" "1546.2" "" "" "" "" "" "" "" "" "" "" "1464.1" "1243.1" "1445.3" "1249.2" "1353.1" "1510.7" "1438.3" "1369.0" "1469.8" "1488.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1264593624988505849" "False" "High" "IsMasterProtein" "Q14694" "Ubiquitin carboxyl-terminal hydrolase 10 OS=Homo sapiens OX=9606 GN=USP10 PE=1 SV=2" "0.000" "False" "35.842" "14" "11" "15" "11" "798" "87.1" "5.31" "56.94" "11" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00443, Pf07145" "9100" "ENSG00000103194" "USP10" "B2RDJ8; B4DS84; hsa:9100; Q14694; Q9BWG7; Q9NSL7" "VEGFA-VEGFR2 signaling" "Ub-specific processing proteases; Termination of translesion DNA synthesis" "3" "0" "1.017" "1.092" "1.020" "1.070" "1.144" "1.030" "1.142" "1.129" "1.040" "1440.7" "1465.9" "1573.0" "1469.0" "1542.1" "1648.7" "1483.7" "1645.9" "1626.1" "1497.9" "" "" "" "" "" "" "" "" "" "" "1349.9" "1213.0" "1460.3" "1135.6" "1314.4" "1575.2" "1355.7" "1461.4" "1626.1" "1442.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6424990256346318104" "False" "High" "IsMasterProtein" "P04792" "Heat shock protein beta-1 OS=Homo sapiens OX=9606 GN=HSPB1 PE=1 SV=2" "0.000" "False" "35.833" "45" "9" "20" "9" "205" "22.8" "6.40" "69.10" "9" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00011" "3315" "ENSG00000106211" "HSPB1" "B2R4N8; hsa:3315; P04792; Q6FI47; Q96C20; Q96EI7; Q9UC31; Q9UC34; Q9UC35; Q9UC36" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; p38 MAPK signaling pathway; Extracellular vesicles in the crosstalk of cardiac cells; Ferroptosis; IL-18 signaling pathway; Intracellular trafficking proteins involved in CMT neuropathy; GDNF signaling; Macrophage-stimulating protein (MSP) signaling network map; 7q11.23 distal copy number variation; HDAC6 interactions in the central nervous system" "AUF1 (hnRNP D0) binds and destabilizes mRNA; MAPK6/MAPK4 signaling; Extra-nuclear estrogen signaling; VEGFA-VEGFR2 Pathway" "18" "0" "1.007" "0.984" "1.007" "0.942" "0.936" "0.856" "0.884" "0.853" "0.947" "1755.5" "1767.0" "1727.4" "1768.1" "1653.1" "1643.5" "1502.5" "1552.1" "1497.0" "1661.9" "" "" "" "" "" "" "" "" "" "" "1644.9" "1462.2" "1603.7" "1366.8" "1409.0" "1570.2" "1372.9" "1378.1" "1497.0" "1600.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6782447041087316008" "False" "High" "IsMasterProtein" "Q9UNF0" "Protein kinase C and casein kinase substrate in neurons protein 2 OS=Homo sapiens OX=9606 GN=PACSIN2 PE=1 SV=2" "0.000" "False" "35.800" "30" "12" "14" "12" "486" "55.7" "5.20" "44.38" "12" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00611, Pf14604" "11252" "ENSG00000100266" "PACSIN2" "hsa:11252; O95921; Q96HV9; Q9H0D3; Q9NPN1; Q9UNF0; Q9Y4V2" "" "Clathrin-mediated endocytosis" "1" "0" "1.003" "0.974" "0.948" "1.013" "1.025" "0.940" "1.018" "0.990" "1.008" "1684.1" "1689.4" "1640.7" "1596.1" "1706.7" "1725.8" "1583.3" "1715.3" "1667.9" "1696.8" "" "" "" "" "" "" "" "" "" "" "1578.0" "1398.0" "1523.2" "1233.9" "1454.8" "1648.9" "1446.7" "1523.0" "1667.9" "1633.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2093622632730469128" "False" "High" "IsMasterProtein" "Q15418" "Ribosomal protein S6 kinase alpha-1 OS=Homo sapiens OX=9606 GN=RPS6KA1 PE=1 SV=2" "0.000" "False" "35.724" "18" "13" "16" "7" "735" "82.7" "7.83" "46.40" "13" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00433" "6195" "ENSG00000117676; ENSG00000281877" "RPS6KA1" "A6NGG4; A8K9K7; B2RDY8; B7Z5J0; E9PRI4; hsa:6195; Q15418; Q5SVM5; Q5SVM8; Q5SVM9; Q96C05; Q9BQK2" "IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; BDNF-TrkB signaling; Angiopoietin-like protein 8 regulatory pathway; TYROBP causal network in microglia; Thermogenesis; EGF/EGFR signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cytoplasmic ribosomal proteins; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Hippocampal synaptogenesis and neurogenesis; Macrophage-stimulating protein (MSP) signaling network map" "Recycling pathway of L1; Senescence-Associated Secretory Phenotype (SASP); RSK activation; ERK/MAPK targets; CREB phosphorylation; Gastrin-CREB signalling pathway via PKC and MAPK" "26" "2" "0.953" "0.999" "0.945" "0.916" "0.976" "0.918" "0.893" "0.872" "0.920" "1183.8" "1128.1" "1182.4" "1118.6" "1084.4" "1155.3" "1086.4" "1056.9" "1031.9" "1089.2" "" "" "" "" "" "" "" "" "" "" "1109.2" "933.5" "1097.8" "864.7" "924.3" "1103.8" "992.7" "938.4" "1031.9" "1048.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5720484629679422275" "False" "High" "IsMasterProtein" "Q8WUA2" "Peptidyl-prolyl cis-trans isomerase-like 4 OS=Homo sapiens OX=9606 GN=PPIL4 PE=1 SV=1" "0.000" "False" "35.709" "21" "11" "19" "11" "492" "57.2" "5.92" "53.40" "11" "" "cytosol;nucleus" "other molecular function" "Pf00076, Pf00160" "85313" "ENSG00000131013" "PPIL4" "B2RD34; hsa:85313; Q7Z3Q5; Q8WUA2" "" "mRNA Splicing - Major Pathway" "1" "0" "1.007" "1.038" "1.058" "1.069" "1.077" "1.072" "1.064" "1.034" "1.074" "1515.4" "1526.0" "1572.4" "1603.3" "1620.3" "1631.5" "1624.4" "1612.0" "1567.0" "1626.9" "" "" "" "" "" "" "" "" "" "" "1419.9" "1262.8" "1459.7" "1239.4" "1381.1" "1558.7" "1484.3" "1431.3" "1567.0" "1566.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4709536422529614216" "False" "High" "IsMasterProtein" "P20618" "Proteasome subunit beta type-1 OS=Homo sapiens OX=9606 GN=PSMB1 PE=1 SV=2" "0.000" "False" "35.699" "41" "9" "19" "9" "241" "26.5" "8.13" "66.25" "9" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227" "5689" "ENSG00000008018" "PSMB1" "B5BU76; hsa:5689; P20618; Q9BWA8" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Neutrophil degranulation" "63" "0" "0.988" "1.003" "0.963" "0.982" "1.037" "0.916" "0.976" "0.972" "0.973" "1326.9" "1311.2" "1330.5" "1278.1" "1302.5" "1376.5" "1215.1" "1294.5" "1289.4" "1291.6" "" "" "" "" "" "" "" "" "" "" "1243.3" "1085.0" "1235.2" "988.0" "1110.2" "1315.1" "1110.3" "1149.4" "1289.4" "1243.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8469309847663247920" "False" "High" "IsMasterProtein" "Q9UEY8" "Gamma-adducin OS=Homo sapiens OX=9606 GN=ADD3 PE=1 SV=1" "0.000" "False" "35.665" "18" "11" "12" "11" "706" "79.1" "6.32" "41.53" "11" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "120" "ENSG00000148700" "ADD3" "D3DRA8; hsa:120; O43243; Q5VU09; Q92773; Q9UEY7; Q9UEY8" "" "Miscellaneous transport and binding events; RHOD GTPase cycle; RHOF GTPase cycle" "3" "0" "1.029" "0.993" "1.064" "1.077" "1.008" "1.038" "1.011" "1.039" "1.034" "1105.2" "1137.6" "1097.5" "1176.5" "1190.1" "1114.2" "1147.2" "1116.9" "1148.2" "1142.9" "" "" "" "" "" "" "" "" "" "" "1035.6" "941.4" "1018.9" "909.5" "1014.4" "1064.5" "1048.2" "991.7" "1148.2" "1100.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832303337719112949" "False" "High" "IsMasterProtein" "Q15154" "Pericentriolar material 1 protein OS=Homo sapiens OX=9606 GN=PCM1 PE=1 SV=6" "0.000" "False" "35.655" "7" "14" "15" "13" "2024" "228.4" "5.02" "42.65" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15717" "5108" "ENSG00000078674" "PCM1" "A6NNN6; B4DYD5; E7ETA6; E7EV56; hsa:5108; Q15154; Q58F13; Q6P1K7; Q8NB85; Q9BWC1; Q9H4A2" "Prader-Willi and Angelman syndrome; Joubert syndrome" "Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "9" "0" "1.033" "0.998" "1.021" "0.987" "1.007" "1.084" "1.038" "1.048" "1.023" "1641.6" "1696.2" "1637.6" "1676.5" "1619.9" "1653.0" "1778.7" "1704.5" "1720.9" "1679.2" "" "" "" "" "" "" "" "" "" "" "1538.2" "1403.5" "1520.3" "1296.0" "1380.7" "1579.2" "1625.3" "1513.4" "1720.9" "1616.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8832352295829315313" "False" "High" "IsMasterProtein" "P09622" "Dihydrolipoyl dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=DLD PE=1 SV=2" "0.000" "False" "35.649" "22" "11" "16" "11" "509" "54.1" "7.85" "49.61" "11" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02852, Pf07992" "1738" "ENSG00000091140" "DLD" "B2R5X0; B4DHG0; B4DT69; hsa:1738; P09622; Q14131; Q14167; Q59EV8; Q8WTS4" "Fatty acid beta-oxidation; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Tryptophan metabolism; 7q11.23 copy number variation syndrome; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; 10q11.21q11.23 copy number variation syndrome; Metabolic Epileptic Disorders; TCA cycle (aka Krebs or citric acid cycle)" "Lysine catabolism; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Citric acid cycle (TCA cycle); Branched-chain amino acid catabolism; Mitochondrial protein degradation; Glycine degradation" "19" "0" "0.996" "0.998" "0.998" "0.977" "1.018" "0.984" "1.005" "0.966" "0.959" "2608.6" "2599.1" "2602.7" "2602.1" "2547.4" "2654.3" "2566.1" "2620.9" "2519.7" "2501.7" "" "" "" "" "" "" "" "" "" "" "2444.3" "2150.7" "2416.3" "2011.6" "2171.4" "2535.9" "2344.8" "2327.1" "2519.7" "2408.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6313231503744566384" "False" "High" "IsMasterProtein" "O00754" "Lysosomal alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2B1 PE=1 SV=3" "0.000" "False" "35.619" "12" "12" "16" "12" "1011" "113.7" "7.28" "50.99" "12" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01074, Pf07748, Pf09261, Pf21260" "4125" "ENSG00000104774" "MAN2B1" "G5E928; hsa:4125; O00754; O15330; Q16680; Q93094; Q9BW13" "" "Neutrophil degranulation; Lysosomal oligosaccharide catabolism" "2" "0" "0.952" "0.897" "1.003" "0.954" "1.010" "0.917" "0.926" "0.939" "0.935" "2099.0" "1998.2" "1882.8" "2105.1" "2001.9" "2120.9" "1924.2" "1943.0" "1970.7" "1963.0" "" "" "" "" "" "" "" "" "" "" "1966.7" "1653.5" "1747.9" "1627.4" "1706.4" "2026.3" "1758.3" "1725.2" "1970.7" "1890.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7376822484090122143" "False" "High" "IsMasterProtein" "P05166" "Propionyl-CoA carboxylase beta chain, mitochondrial OS=Homo sapiens OX=9606 GN=PCCB PE=1 SV=3" "0.000" "False" "35.594" "26" "11" "12" "11" "539" "58.2" "7.64" "35.83" "11" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01039" "5096" "ENSG00000114054" "PCCB" "B7Z2Z4; hsa:5096; P05166; Q16813; Q96CX0" "Primary ovarian insufficiency" "Biotin transport and metabolism; Mitochondrial protein degradation; Defective HLCS causes multiple carboxylase deficiency; Propionyl-CoA catabolism" "5" "0" "1.058" "1.016" "1.089" "1.044" "1.041" "1.052" "1.002" "1.016" "1.016" "726.9" "769.2" "738.7" "791.7" "758.6" "756.4" "765.0" "728.2" "738.3" "738.8" "" "" "" "" "" "" "" "" "" "" "681.1" "636.5" "685.8" "612.0" "646.7" "722.7" "699.0" "646.6" "738.3" "711.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4786951349264090061" "False" "High" "IsMasterProtein" "Q9P2I0" "Cleavage and polyadenylation specificity factor subunit 2 OS=Homo sapiens OX=9606 GN=CPSF2 PE=1 SV=2" "0.000" "False" "35.554" "18" "13" "18" "13" "782" "88.4" "5.11" "54.05" "13" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07521, Pf10996, Pf13299, Pf16661" "53981" "ENSG00000165934" "CPSF2" "B3KME1; hsa:53981; Q6NSJ1; Q9H3W7; Q9P2I0" "mRNA processing" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "6" "0" "0.991" "1.020" "1.073" "1.053" "1.046" "1.199" "1.275" "1.175" "1.124" "2474.0" "2451.0" "2523.6" "2654.5" "2605.8" "2587.3" "2965.2" "3154.6" "2907.4" "2780.4" "" "" "" "" "" "" "" "" "" "" "2318.1" "2028.2" "2342.9" "2052.1" "2221.1" "2471.9" "2709.4" "2800.9" "2907.4" "2677.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7260357318160893257" "False" "High" "IsMasterProtein" "O75439" "Mitochondrial-processing peptidase subunit beta OS=Homo sapiens OX=9606 GN=PMPCB PE=1 SV=2" "0.000" "False" "35.505" "23" "11" "15" "10" "489" "54.3" "6.83" "56.97" "11" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion" "other molecular function" "Pf00675, Pf05193" "9512" "ENSG00000105819" "PMPCB" "hsa:9512; O60416; O75439; Q96FV4" "" "Mitochondrial protein import; Processing of SMDT1" "2" "1" "1.009" "0.986" "1.057" "1.029" "1.036" "1.033" "1.055" "0.995" "0.988" "1266.7" "1278.7" "1249.4" "1338.6" "1302.9" "1311.9" "1308.7" "1335.7" "1259.8" "1251.9" "" "" "" "" "" "" "" "" "" "" "1186.9" "1058.1" "1159.9" "1034.8" "1110.5" "1253.4" "1195.8" "1186.0" "1259.8" "1205.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2926679715344885449" "False" "High" "IsMasterProtein" "O94913" "Pre-mRNA cleavage complex 2 protein Pcf11 OS=Homo sapiens OX=9606 GN=PCF11 PE=1 SV=3" "0.000" "False" "35.463" "9" "13" "16" "13" "1555" "172.9" "8.48" "41.92" "13" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04818, Pf11526, Pf20827, Pf20844, Pf20845" "51585" "ENSG00000165494" "PCF11" "A6H8W7; hsa:51585; O43671; O94913; Q6P0X8" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RNA polymerase II transcribes snRNA genes; Processing of Intronless Pre-mRNAs" "5" "0" "1.009" "1.005" "1.003" "0.984" "1.014" "0.900" "0.899" "0.906" "0.967" "1288.5" "1299.8" "1294.7" "1291.9" "1268.5" "1307.0" "1160.1" "1158.5" "1166.9" "1245.6" "" "" "" "" "" "" "" "" "" "" "1207.4" "1075.6" "1202.0" "998.7" "1081.3" "1248.7" "1060.0" "1028.7" "1166.9" "1199.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8470194220236547975" "False" "High" "IsMasterProtein" "Q5TBB1" "Ribonuclease H2 subunit B OS=Homo sapiens OX=9606 GN=RNASEH2B PE=1 SV=1" "0.000" "False" "35.454" "31" "11" "17" "11" "312" "35.1" "9.13" "58.12" "11" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf09468, Pf17745" "79621" "ENSG00000136104" "RNASEH2B" "G3XAJ1; hsa:79621; Q05DR2; Q5TBB1; Q6PK48; Q9HAF7" "" "" "0" "0" "1.038" "1.026" "1.024" "1.010" "1.033" "1.035" "0.999" "1.078" "1.071" "2075.1" "2154.1" "2128.2" "2125.2" "2095.8" "2144.0" "2148.2" "2073.1" "2236.5" "2222.8" "" "" "" "" "" "" "" "" "" "" "1944.4" "1782.5" "1975.7" "1642.9" "1786.4" "2048.4" "1962.9" "1840.7" "2236.5" "2140.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "556799029181218119" "False" "High" "IsMasterProtein" "Q13596" "Sorting nexin-1 OS=Homo sapiens OX=9606 GN=SNX1 PE=1 SV=3" "0.000" "False" "35.440" "22" "10" "15" "8" "522" "59.0" "5.15" "50.80" "10" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf03700, Pf09325" "6642" "ENSG00000028528" "SNX1" "A6NM19; A8K6T7; H0Y2M5; hsa:6642; O60750; O60751; Q13596; Q6ZRJ8" "" "" "0" "0" "1.047" "1.010" "1.095" "1.093" "1.033" "1.025" "1.049" "1.047" "1.029" "886.1" "928.2" "895.3" "970.0" "968.3" "915.8" "908.3" "929.5" "927.3" "911.6" "" "" "" "" "" "" "" "" "" "" "830.3" "768.0" "831.2" "749.9" "825.4" "874.9" "830.0" "825.3" "927.3" "877.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2236542177406705002" "False" "High" "IsMasterProtein" "P52597" "Heterogeneous nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=HNRNPF PE=1 SV=3" "0.000" "False" "35.434" "30" "9" "31" "7" "415" "45.6" "5.58" "118.02" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08080" "3185" "ENSG00000169813" "HNRNPF" "B3KM84; hsa:3185; P52597; Q5T0N2; Q96AU2" "MECP2 and associated Rett syndrome" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "5" "0" "0.969" "1.016" "0.975" "1.034" "0.995" "0.974" "0.972" "1.013" "0.985" "1759.3" "1705.3" "1787.1" "1714.6" "1818.9" "1749.7" "1714.4" "1710.9" "1781.3" "1732.4" "" "" "" "" "" "" "" "" "" "" "1648.5" "1411.1" "1659.1" "1325.4" "1550.3" "1671.6" "1566.5" "1519.1" "1781.3" "1668.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7305935062523076867" "False" "High" "IsMasterProtein" "Q9Y3Z3" "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Homo sapiens OX=9606 GN=SAMHD1 PE=1 SV=2" "0.000" "False" "35.412" "20" "12" "15" "12" "626" "72.2" "7.14" "51.25" "12" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01966, Pf07647" "25939" "ENSG00000101347" "SAMHD1" "B4E2A5; E1P5V2; hsa:25939; Q5JXG8; Q8N491; Q9H004; Q9H005; Q9H3U9; Q9Y3Z3" "" "Interferon alpha/beta signaling; Nucleotide catabolism" "2" "0" "1.036" "1.042" "1.055" "1.059" "1.011" "1.006" "0.982" "0.974" "1.006" "1871.8" "1939.0" "1950.1" "1975.4" "1981.9" "1892.7" "1883.5" "1838.9" "1822.7" "1883.8" "" "" "" "" "" "" "" "" "" "" "1753.9" "1604.5" "1810.4" "1527.1" "1689.3" "1808.3" "1721.0" "1632.7" "1822.7" "1813.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5857660237806613264" "False" "High" "IsMasterProtein" "Q9NXV6" "CDKN2A-interacting protein OS=Homo sapiens OX=9606 GN=CDKN2AIP PE=1 SV=3" "0.000" "False" "35.412" "23" "11" "14" "11" "580" "61.1" "9.01" "41.82" "11" "stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf11952" "55602" "ENSG00000168564" "CDKN2AIP" "hsa:55602; Q8TBM5; Q9NXV6; Q9NYH0" "" "" "0" "0" "0.893" "1.073" "0.940" "1.015" "0.933" "0.923" "0.944" "0.924" "0.943" "1790.0" "1597.8" "1920.9" "1682.4" "1816.7" "1669.9" "1651.4" "1690.3" "1653.9" "1687.6" "" "" "" "" "" "" "" "" "" "" "1677.3" "1322.1" "1783.3" "1300.6" "1548.5" "1595.4" "1508.9" "1500.8" "1653.9" "1624.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3635452200201599036" "False" "High" "IsMasterProtein" "Q12904" "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Homo sapiens OX=9606 GN=AIMP1 PE=1 SV=2" "0.000" "False" "35.388" "41" "11" "15" "11" "312" "34.3" "8.43" "57.37" "11" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf01588" "9255" "ENSG00000164022" "AIMP1" "B3KTR2; B4E1S7; hsa:9255; Q12904; Q6FG28; Q96CQ9" "Ciliary landscape" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "3" "0" "1.090" "0.947" "0.998" "0.998" "1.040" "0.884" "0.988" "1.099" "1.023" "2031.7" "2214.7" "1924.4" "2027.0" "2027.7" "2113.5" "1796.7" "2006.5" "2233.2" "2077.5" "" "" "" "" "" "" "" "" "" "" "1903.7" "1832.6" "1786.5" "1567.0" "1728.4" "2019.2" "1641.7" "1781.6" "2233.2" "2000.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8315542899134672596" "False" "High" "IsMasterProtein" "O94804" "Serine/threonine-protein kinase 10 OS=Homo sapiens OX=9606 GN=STK10 PE=1 SV=1" "0.000" "False" "35.356" "11" "13" "19" "12" "968" "112.1" "6.95" "43.92" "13" "cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12474" "6793" "ENSG00000072786" "STK10" "A6ND35; B2R8F5; B3KMY1; hsa:6793; O94804; Q6NSK0; Q9UIW4" "" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Neutrophil degranulation" "4" "0" "1.035" "1.018" "1.021" "1.028" "1.097" "0.979" "0.922" "0.976" "1.044" "1211.8" "1254.5" "1233.5" "1237.6" "1245.9" "1329.3" "1186.3" "1117.0" "1182.9" "1264.8" "" "" "" "" "" "" "" "" "" "" "1135.5" "1038.1" "1145.2" "956.7" "1061.9" "1270.0" "1084.0" "991.8" "1182.9" "1217.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2805084755290845876" "False" "High" "IsMasterProtein" "Q09161" "Nuclear cap-binding protein subunit 1 OS=Homo sapiens OX=9606 GN=NCBP1 PE=1 SV=1" "0.000" "False" "35.290" "16" "11" "14" "11" "790" "91.8" "6.43" "47.26" "11" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02854, Pf09088, Pf09090" "4686" "ENSG00000136937" "NCBP1" "B2R718; hsa:4686; Q09161; Q59G76; Q5T1V0; Q5T7X2" "mRNA processing; 3q29 copy number variation syndrome" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RNA polymerase II transcribes snRNA genes; Processing of Intronless Pre-mRNAs; Regulation of expression of SLITs and ROBOs; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; snRNP Assembly; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Polymerase II Pre-transcription Events; mRNA Capping; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "29" "0" "0.937" "1.019" "1.044" "0.993" "1.009" "1.151" "1.059" "1.095" "1.017" "1249.4" "1170.9" "1272.6" "1304.8" "1240.7" "1260.3" "1437.5" "1322.6" "1368.3" "1270.5" "" "" "" "" "" "" "" "" "" "" "1170.6" "968.9" "1181.5" "1008.7" "1057.5" "1204.1" "1313.5" "1174.3" "1368.3" "1223.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8481404637455697567" "False" "High" "IsMasterProtein" "Q9C0B1" "Alpha-ketoglutarate-dependent dioxygenase FTO OS=Homo sapiens OX=9606 GN=FTO PE=1 SV=3" "0.000" "False" "35.209" "28" "13" "17" "13" "505" "58.2" "5.22" "46.74" "13" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12933, Pf12934" "79068" "ENSG00000140718" "FTO" "A2RUH1; B2RNS0; hsa:79068; Q0P676; Q7Z785; Q9C0B1" "FTO obesity variant mechanism" "Reversal of alkylation damage by DNA dioxygenases" "2" "0" "0.979" "0.961" "0.963" "0.956" "1.005" "0.910" "0.965" "0.979" "0.965" "1952.5" "1910.7" "1875.6" "1880.6" "1866.0" "1961.4" "1777.5" "1883.5" "1910.7" "1883.6" "" "" "" "" "" "" "" "" "" "" "1829.5" "1581.1" "1741.2" "1453.8" "1590.5" "1873.9" "1624.2" "1672.4" "1910.7" "1813.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4576818443980197018" "False" "High" "IsMasterProtein" "P52292" "Importin subunit alpha-1 OS=Homo sapiens OX=9606 GN=KPNA2 PE=1 SV=1" "0.000" "False" "35.143" "24" "10" "18" "10" "529" "57.8" "5.40" "66.33" "10" "DNA metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3838" "ENSG00000182481" "KPNA2" "B9EJD6; hsa:3838; P52292; Q53YE3; Q6NVW7; Q9BRU5" "" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Estrogen-dependent gene expression; SARS-CoV-1 activates/modulates innate immune responses; Sensing of DNA Double Strand Breaks; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde" "8" "0" "0.973" "1.020" "1.086" "1.033" "1.008" "1.056" "1.054" "1.031" "1.039" "1318.0" "1282.0" "1345.0" "1431.8" "1361.8" "1328.4" "1391.5" "1389.2" "1359.3" "1369.3" "" "" "" "" "" "" "" "" "" "" "1235.0" "1060.8" "1248.6" "1106.9" "1160.8" "1269.1" "1271.4" "1233.5" "1359.3" "1318.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2170038667873591835" "False" "High" "IsMasterProtein" "O15027" "Protein transport protein Sec16A OS=Homo sapiens OX=9606 GN=SEC16A PE=1 SV=4" "0.000" "False" "35.139" "6" "13" "15" "13" "2357" "251.7" "5.80" "47.83" "13" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "" "Pf12931, Pf12932" "9919" "ENSG00000148396" "SEC16A" "A1YCA4; hsa:9919; J3KNL6; O15027; Q4G0D7; Q5SXP0; Q5SXP1; Q8N347; Q96HP1" "" "COPII-mediated vesicle transport" "1" "0" "0.988" "1.000" "0.973" "1.017" "1.031" "1.000" "0.965" "0.962" "1.009" "1460.2" "1442.6" "1459.5" "1420.6" "1485.7" "1505.9" "1459.5" "1409.7" "1404.8" "1473.5" "" "" "" "" "" "" "" "" "" "" "1368.2" "1193.7" "1354.9" "1098.2" "1266.4" "1438.7" "1333.6" "1251.7" "1404.8" "1418.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5215357132518723376" "False" "High" "IsMasterProtein" "P30040" "Endoplasmic reticulum resident protein 29 OS=Homo sapiens OX=9606 GN=ERP29 PE=1 SV=4" "0.000" "False" "35.110" "40" "10" "20" "10" "261" "29.0" "7.31" "57.15" "10" "protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf07749, Pf07912" "10961" "ENSG00000089248" "ERP29" "C9J183; hsa:10961; P30040; Q3MJC3; Q6FHT4" "" "" "0" "0" "1.165" "0.994" "1.025" "1.043" "1.025" "0.990" "1.018" "1.022" "1.017" "2202.0" "2566.4" "2187.7" "2256.3" "2297.2" "2257.5" "2180.4" "2241.9" "2249.5" "2240.4" "" "" "" "" "" "" "" "" "" "" "2063.3" "2123.6" "2031.0" "1744.3" "1958.1" "2156.8" "1992.3" "1990.6" "2249.5" "2157.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3101677286908017403" "False" "High" "IsMasterProtein" "Q9Y450" "HBS1-like protein OS=Homo sapiens OX=9606 GN=HBS1L PE=1 SV=1" "0.000" "False" "35.095" "18" "12" "15" "12" "684" "75.4" "6.61" "43.19" "12" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144, Pf08938" "10767" "ENSG00000112339" "HBS1L" "B7Z365; hsa:10767; Q4VX89; Q4VX90; Q5T7G3; Q8NDW9; Q9UPW3; Q9Y450" "" "mRNA decay by 3' to 5' exoribonuclease" "1" "0" "1.030" "1.027" "1.008" "1.035" "1.031" "1.035" "0.996" "1.021" "1.028" "2176.5" "2242.4" "2236.0" "2194.9" "2253.2" "2243.2" "2252.6" "2167.9" "2221.1" "2236.8" "" "" "" "" "" "" "" "" "" "" "2039.4" "1855.6" "2075.9" "1696.7" "1920.5" "2143.2" "2058.3" "1924.9" "2221.1" "2153.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6086246065885053041" "False" "High" "IsMasterProtein" "Cont_P02533" "Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4" "0.000" "True" "35.086" "20" "13" "20" "3" "472" "51.5" "5.16" "49.88" "13" "cell organization and biogenesis;other biological processes" "plasma membrane;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00038" "3861" "ENSG00000186847" "KRT14" "hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4" "Corticotropin-releasing hormone signaling pathway" "Formation of the cornified envelope; Type I hemidesmosome assembly" "4" "3" "1.190" "0.630" "0.681" "0.638" "0.677" "1.922" "0.727" "0.578" "0.837" "677.9" "806.7" "427.0" "461.5" "432.6" "458.7" "1303.2" "493.1" "391.6" "567.7" "" "" "" "" "" "" "" "" "" "" "635.2" "667.5" "396.4" "356.8" "368.7" "438.3" "1190.7" "437.8" "391.6" "546.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8386147216843783893" "False" "High" "IsMasterProtein" "Q9NUU7" "ATP-dependent RNA helicase DDX19A OS=Homo sapiens OX=9606 GN=DDX19A PE=1 SV=1" "0.000" "False" "35.071" "21" "10" "17" "1" "478" "53.9" "6.58" "51.36" "10" "other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "55308" "ENSG00000168872" "DDX19A" "B2RPL0; B4DRZ7; hsa:55308; Q53FM0; Q9NUU7" "" "" "0" "6" "1.046" "1.035" "1.009" "0.929" "0.965" "0.822" "0.959" "0.960" "0.965" "1914.2" "2002.7" "1980.5" "1932.1" "1778.5" "1847.5" "1574.4" "1835.2" "1837.5" "1846.5" "" "" "" "" "" "" "" "" "" "" "1793.6" "1657.2" "1838.6" "1493.6" "1516.0" "1765.2" "1438.6" "1629.4" "1837.5" "1777.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-61842363996650095" "False" "High" "IsMasterProtein" "P19623" "Spermidine synthase OS=Homo sapiens OX=9606 GN=SRM PE=1 SV=1" "0.000" "False" "35.061" "40" "9" "20" "9" "302" "33.8" "5.49" "70.52" "9" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01564, Pf17284" "6723" "ENSG00000116649" "SRM" "B1AKP9; hsa:6723; P19623; Q15511" "Methionine de novo and salvage pathway; Amino acid metabolism" "Metabolism of polyamines" "3" "0" "0.968" "0.950" "0.987" "0.958" "0.948" "0.941" "0.931" "1.014" "0.936" "1880.4" "1821.0" "1785.7" "1855.2" "1801.9" "1783.4" "1769.7" "1750.8" "1907.5" "1760.0" "" "" "" "" "" "" "" "" "" "" "1761.9" "1506.9" "1657.8" "1434.1" "1535.9" "1703.8" "1617.0" "1554.5" "1907.5" "1694.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4534228375388649933" "False" "High" "IsMasterProtein" "P52948" "Nuclear pore complex protein Nup98-Nup96 OS=Homo sapiens OX=9606 GN=NUP98 PE=1 SV=4" "0.000" "False" "35.054" "7" "12" "13" "12" "1817" "197.5" "6.40" "32.93" "12" "cell organization and biogenesis;protein metabolism;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04096, Pf12110, Pf21240" "4928" "ENSG00000110713" "NUP98" "hsa:4928; P52948; Q8IUT2; Q8WYB0; Q96E54; Q9H3Q4; Q9NT02; Q9UF57; Q9UHX0; Q9Y6J4; Q9Y6J5" "SARS-CoV-2 innate immunity evasion and cell-specific immune response" "" "1" "0" "1.060" "1.072" "1.023" "1.082" "1.088" "1.070" "1.066" "1.124" "1.089" "1082.7" "1147.7" "1161.2" "1107.8" "1171.5" "1177.8" "1158.4" "1154.2" "1216.9" "1178.6" "" "" "" "" "" "" "" "" "" "" "1014.5" "949.7" "1078.0" "856.4" "998.5" "1125.3" "1058.4" "1024.8" "1216.9" "1134.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4701772359172858038" "False" "High" "IsMasterProtein" "P49790" "Nuclear pore complex protein Nup153 OS=Homo sapiens OX=9606 GN=NUP153 PE=1 SV=2" "0.000" "False" "35.051" "9" "13" "16" "13" "1475" "153.8" "8.73" "44.26" "13" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00641, Pf08604, Pf10599" "9972" "ENSG00000124789" "NUP153" "B4DIK2; E7EPX5; F6QR24; hsa:9972; P49790; Q4LE47; Q5T9I7; Q7Z743" "TGF-beta signaling pathway" "Nuclear import of Rev protein; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; SUMOylation of DNA replication proteins; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "29" "0" "1.006" "1.012" "1.033" "1.063" "1.054" "1.126" "1.176" "1.072" "1.086" "1481.6" "1490.6" "1499.1" "1530.4" "1574.4" "1562.3" "1668.6" "1743.0" "1589.0" "1609.1" "" "" "" "" "" "" "" "" "" "" "1388.3" "1233.4" "1391.7" "1183.1" "1342.0" "1492.7" "1524.7" "1547.6" "1589.0" "1549.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2904127799800100027" "False" "High" "IsMasterProtein" "Q8IYS1" "Xaa-Arg dipeptidase OS=Homo sapiens OX=9606 GN=PM20D2 PE=1 SV=2" "0.000" "False" "35.036" "26" "10" "17" "10" "436" "47.7" "5.85" "58.16" "10" "protein metabolism;other biological processes" "nucleus" "other molecular function" "Pf01546, Pf07687" "135293" "ENSG00000146281" "PM20D2" "B4DYJ2; hsa:135293; Q5T7J9; Q6MZV2; Q86XD9; Q8IYS1" "" "" "0" "0" "0.930" "0.953" "0.928" "0.893" "0.956" "0.894" "0.948" "0.906" "0.889" "2157.6" "2006.8" "2056.4" "2003.2" "1927.5" "2062.5" "1927.9" "2044.9" "1953.8" "1917.5" "" "" "" "" "" "" "" "" "" "" "2021.7" "1660.6" "1909.1" "1548.6" "1642.9" "1970.6" "1761.6" "1815.6" "1953.8" "1846.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6179525910857735181" "False" "High" "IsMasterProtein" "P49590" "Histidine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=HARS2 PE=1 SV=1" "0.000" "False" "35.007" "19" "11" "15" "6" "506" "56.9" "8.24" "51.88" "11" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf03129, Pf13393" "23438" "ENSG00000112855" "HARS2" "B4DDY8; hsa:23438; P49590" "Primary ovarian insufficiency" "Mitochondrial tRNA aminoacylation" "2" "0" "0.940" "1.035" "1.023" "1.017" "0.998" "1.032" "0.993" "0.996" "1.022" "646.4" "607.5" "668.9" "661.3" "657.4" "645.1" "667.1" "642.1" "644.1" "660.9" "" "" "" "" "" "" "" "" "" "" "605.7" "502.7" "621.0" "511.2" "560.4" "616.3" "609.6" "570.1" "644.1" "636.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "275596885495269995" "False" "High" "IsMasterProtein" "Q14166" "Tubulin--tyrosine ligase-like protein 12 OS=Homo sapiens OX=9606 GN=TTLL12 PE=1 SV=2" "0.000" "False" "34.926" "18" "9" "14" "9" "644" "74.4" "5.53" "43.61" "9" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03133" "23170" "ENSG00000100304" "TTLL12" "hsa:23170; Q14166; Q20WK5; Q9UGU3" "" "Carboxyterminal post-translational modifications of tubulin" "1" "0" "1.022" "1.064" "1.033" "0.965" "1.026" "0.990" "0.982" "1.018" "1.005" "674.6" "689.6" "717.4" "696.7" "651.3" "692.4" "668.1" "662.5" "686.5" "678.2" "" "" "" "" "" "" "" "" "" "" "632.1" "570.6" "666.1" "538.6" "555.1" "661.5" "610.5" "588.3" "686.5" "653.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5818593354028515611" "False" "High" "IsMasterProtein" "P56524" "Histone deacetylase 4 OS=Homo sapiens OX=9606 GN=HDAC4 PE=1 SV=3" "0.000" "False" "34.910" "10" "10" "11" "10" "1084" "119.0" "6.96" "36.04" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850, Pf12203" "9759" "ENSG00000068024" "HDAC4" "E9PGB9; F5GX36; hsa:9759; P56524; Q86YH7; Q9UND6" "MicroRNAs in cardiomyocyte hypertrophy; Genes targeted by miRNAs in adipocytes; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Endochondral ossification; Endochondral ossification with skeletal dysplasias; CAMKK2 pathway; 2q37 copy number variation syndrome" "SUMOylation of chromatin organization proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SUMOylation of intracellular receptors; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX3 regulates p14-ARF; RUNX2 regulates chondrocyte maturation" "20" "0" "1.012" "0.955" "1.024" "0.981" "0.949" "0.998" "0.924" "0.919" "1.016" "710.4" "719.2" "678.2" "727.4" "696.9" "674.1" "708.7" "656.8" "652.6" "721.9" "" "" "" "" "" "" "" "" "" "" "665.7" "595.1" "629.6" "562.3" "594.1" "644.0" "647.6" "583.1" "652.6" "695.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4336688759083416299" "False" "High" "IsMasterProtein" "Q15813" "Tubulin-specific chaperone E OS=Homo sapiens OX=9606 GN=TBCE PE=1 SV=1" "0.000" "False" "34.891" "22" "13" "17" "12" "527" "59.3" "6.76" "52.69" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf14560" "6905" "ENSG00000284770" "TBCE" "A8K8C2; B7Z3P1; Q15813" "" "Post-chaperonin tubulin folding pathway" "1" "1" "0.964" "0.971" "0.923" "0.948" "0.935" "0.998" "0.925" "0.917" "0.978" "2462.7" "2373.0" "2390.4" "2273.6" "2335.1" "2302.9" "2458.2" "2277.8" "2258.9" "2408.3" "" "" "" "" "" "" "" "" "" "" "2307.6" "1963.6" "2219.2" "1757.6" "1990.4" "2200.2" "2246.1" "2022.4" "2258.9" "2318.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5381164833794741619" "False" "High" "IsMasterProtein" "Q9Y5K6" "CD2-associated protein OS=Homo sapiens OX=9606 GN=CD2AP PE=1 SV=1" "0.000" "False" "34.860" "18" "12" "14" "12" "639" "71.4" "6.40" "39.84" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf07653, Pf14604" "23607" "ENSG00000198087" "CD2AP" "A6NL34; hsa:23607; Q5VYA3; Q9UG97; Q9Y5K6" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome; Genes controlling nephrogenesis; GDNF signaling" "Nephrin family interactions" "5" "0" "0.984" "0.965" "0.999" "0.987" "0.973" "0.971" "0.986" "0.964" "0.984" "1880.1" "1850.8" "1813.8" "1878.9" "1855.6" "1828.6" "1825.2" "1853.4" "1812.9" "1849.1" "" "" "" "" "" "" "" "" "" "" "1761.6" "1531.5" "1683.9" "1452.5" "1581.7" "1747.0" "1667.7" "1645.7" "1812.9" "1780.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "408480103546989940" "False" "High" "IsMasterProtein" "Q9Y4C1" "Lysine-specific demethylase 3A OS=Homo sapiens OX=9606 GN=KDM3A PE=1 SV=4" "0.000" "False" "34.774" "8" "11" "12" "10" "1321" "147.2" "8.07" "37.71" "11" "cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "55818" "ENSG00000115548" "KDM3A" "D6W5M3; hsa:55818; Q53S72; Q68D47; Q68UT9; Q6N050; Q8IY08; Q9Y4C1" "Thermogenesis; Male infertility; Vitamin D-sensitive calcium signaling in depression" "HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" "5" "0" "1.020" "1.010" "0.963" "1.010" "0.988" "0.942" "0.921" "0.992" "1.019" "834.2" "850.6" "842.7" "803.4" "842.3" "824.1" "785.8" "768.5" "827.5" "850.3" "" "" "" "" "" "" "" "" "" "" "781.6" "703.9" "782.3" "621.1" "718.0" "787.4" "718.0" "682.3" "827.5" "818.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4791788072284182717" "False" "High" "IsMasterProtein" "Q96GM5" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 OS=Homo sapiens OX=9606 GN=SMARCD1 PE=1 SV=2" "0.000" "False" "34.744" "24" "12" "13" "10" "515" "58.2" "9.25" "49.40" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02201" "6602" "ENSG00000066117" "SMARCD1" "A6NN27; hsa:6602; Q92924; Q96GM5; Q9Y635" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "6" "2" "0.962" "1.006" "0.977" "0.985" "0.960" "1.005" "1.007" "1.016" "1.019" "1689.9" "1626.3" "1699.4" "1651.7" "1664.5" "1622.2" "1698.7" "1702.5" "1716.3" "1722.6" "" "" "" "" "" "" "" "" "" "" "1583.5" "1345.8" "1577.7" "1276.8" "1418.8" "1549.8" "1552.2" "1511.6" "1716.3" "1658.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3792046426100688845" "False" "High" "IsMasterProtein" "O43395" "U4/U6 small nuclear ribonucleoprotein Prp3 OS=Homo sapiens OX=9606 GN=PRPF3 PE=1 SV=2" "0.000" "False" "34.700" "18" "11" "17" "11" "683" "77.5" "9.50" "51.68" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01480, Pf06544, Pf08572" "9129" "ENSG00000117360" "PRPF3" "B4DSY9; hsa:9129; O43395; O43446; Q5VT54" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.989" "1.026" "0.981" "1.016" "0.988" "1.054" "1.035" "1.031" "1.014" "2658.3" "2629.5" "2728.5" "2608.9" "2701.9" "2626.1" "2803.1" "2751.7" "2739.5" "2696.6" "" "" "" "" "" "" "" "" "" "" "2490.8" "2175.9" "2533.0" "2016.8" "2303.0" "2509.0" "2561.3" "2443.2" "2739.5" "2596.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8625580668015925346" "False" "High" "IsMasterProtein" "Q9HCK8" "Chromodomain-helicase-DNA-binding protein 8 OS=Homo sapiens OX=9606 GN=CHD8 PE=1 SV=5" "0.000" "False" "34.655" "5" "14" "15" "9" "2581" "290.3" "6.47" "32.64" "14" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf07533" "57680" "ENSG00000100888" "CHD8" "hsa:57680; Q4G0D8; Q68DQ0; Q6DKH9; Q6P440; Q6ZNL7; Q8N3Z9; Q8NCY4; Q8TBR9; Q96F26; Q9HCK8" "lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma" "Deactivation of the beta-catenin transactivating complex" "5" "0" "0.972" "0.983" "0.944" "0.994" "1.015" "0.949" "0.963" "0.951" "0.987" "1261.1" "1225.6" "1239.8" "1190.1" "1253.9" "1279.7" "1197.1" "1214.2" "1199.0" "1244.7" "" "" "" "" "" "" "" "" "" "" "1181.6" "1014.2" "1151.0" "920.0" "1068.8" "1222.6" "1093.9" "1078.0" "1199.0" "1198.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1088137077242897803" "False" "High" "IsMasterProtein" "P51659" "Peroxisomal multifunctional enzyme type 2 OS=Homo sapiens OX=9606 GN=HSD17B4 PE=1 SV=3" "0.000" "False" "34.614" "14" "9" "15" "9" "736" "79.6" "8.84" "52.67" "9" "other metabolic processes;developmental processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf00106, Pf01575, Pf02036" "3295" "ENSG00000133835" "HSD17B4" "B4DNV1; B4DVS5; E9PB82; F5HE57; hsa:3295; P51659" "Androgen receptor network in prostate cancer; Steroid biosynthesis; Disorders of bile acid synthesis and biliary transport; Primary ovarian insufficiency" "TYSND1 cleaves peroxisomal proteins; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids" "10" "0" "0.991" "0.991" "0.953" "0.965" "1.040" "0.890" "0.926" "0.941" "0.971" "1678.4" "1662.7" "1662.5" "1599.6" "1618.9" "1745.9" "1493.1" "1553.5" "1579.6" "1629.3" "" "" "" "" "" "" "" "" "" "" "1572.7" "1375.9" "1543.4" "1236.6" "1379.9" "1668.0" "1364.3" "1379.4" "1579.6" "1568.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "251900378438964283" "False" "High" "IsMasterProtein" "Q13188" "Serine/threonine-protein kinase 3 OS=Homo sapiens OX=9606 GN=STK3 PE=1 SV=2" "0.000" "False" "34.579" "23" "10" "14" "3" "491" "56.3" "5.24" "41.24" "10" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf11629" "6788" "ENSG00000104375" "STK3" "A8K722; B3KYA7; hsa:6788; Q13188; Q15445; Q15801; Q96FM6" "MAPK signaling pathway; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Leukocyte-intrinsic Hippo pathway functions; Pleural mesothelioma" "Signaling by Hippo" "9" "0" "1.165" "1.110" "1.059" "1.136" "1.166" "0.915" "1.209" "1.152" "1.138" "167.5" "195.1" "185.9" "177.5" "190.3" "195.4" "153.3" "202.6" "192.9" "190.6" "" "" "" "" "" "" "" "" "" "" "157.0" "161.5" "172.5" "137.2" "162.2" "186.6" "140.1" "179.9" "192.9" "183.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5632561991288096733" "False" "High" "IsMasterProtein" "Q9H9Y6" "DNA-directed RNA polymerase I subunit RPA2 OS=Homo sapiens OX=9606 GN=POLR1B PE=1 SV=2" "0.000" "False" "34.574" "10" "13" "14" "13" "1135" "128.1" "7.83" "36.74" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf06883" "84172" "ENSG00000125630" "POLR1B" "B7Z6Y7; B7Z823; F5GZX4; F8W898; hsa:84172; Q2TAM4; Q585T5; Q6ZRR2; Q9H9D3; Q9H9Y6" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "8" "0" "0.964" "0.998" "1.015" "0.997" "0.973" "1.081" "1.094" "1.009" "1.005" "1449.5" "1397.2" "1446.5" "1471.5" "1445.1" "1410.4" "1567.1" "1586.5" "1462.5" "1456.5" "" "" "" "" "" "" "" "" "" "" "1358.2" "1156.2" "1342.9" "1137.6" "1231.8" "1347.6" "1431.9" "1408.6" "1462.5" "1402.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8919089648667332764" "False" "High" "IsMasterProtein" "Q6NZY4" "Zinc finger CCHC domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZCCHC8 PE=1 SV=2" "0.000" "False" "34.554" "20" "11" "18" "11" "707" "78.5" "4.87" "61.23" "11" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00098, Pf04046" "55596" "ENSG00000033030" "ZCCHC8" "hsa:55596; Q6NZY4; Q7L2P6; Q8N2K5; Q96SK7; Q9NSS2; Q9NSS3" "" "" "0" "0" "1.026" "1.024" "1.013" "1.035" "1.054" "0.973" "1.013" "0.988" "1.019" "1892.7" "1941.0" "1938.0" "1916.9" "1958.8" "1994.2" "1841.6" "1917.9" "1869.6" "1928.1" "" "" "" "" "" "" "" "" "" "" "1773.5" "1606.2" "1799.2" "1481.8" "1669.6" "1905.2" "1682.7" "1702.9" "1869.6" "1856.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6335847497915133656" "False" "High" "IsMasterProtein" "Q9BTY7" "Protein HGH1 homolog OS=Homo sapiens OX=9606 GN=HGH1 PE=1 SV=1" "0.000" "False" "34.497" "29" "12" "17" "12" "390" "42.1" "4.81" "48.46" "12" "" "" "" "Pf04063, Pf04064" "51236" "ENSG00000235173" "HGH1" "hsa:51236; P0CB43; Q9BTY7" "" "" "0" "0" "1.031" "0.983" "1.034" "1.025" "1.067" "0.913" "0.938" "0.951" "1.008" "2292.6" "2364.7" "2254.1" "2371.0" "2350.9" "2447.2" "2092.9" "2150.4" "2179.1" "2310.0" "" "" "" "" "" "" "" "" "" "" "2148.2" "1956.8" "2092.6" "1832.9" "2003.9" "2338.1" "1912.4" "1909.3" "2179.1" "2224.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5279606303405418158" "False" "High" "IsMasterProtein" "Q9H2K8" "Serine/threonine-protein kinase TAO3 OS=Homo sapiens OX=9606 GN=TAOK3 PE=1 SV=2" "0.000" "False" "34.496" "13" "14" "15" "11" "898" "105.3" "7.30" "38.60" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "51347" "ENSG00000135090" "TAOK3" "hsa:51347; Q658N1; Q8IUM4; Q9H2K8; Q9HC79; Q9NZM9; Q9UHG7" "MAPK signaling pathway" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle" "4" "2" "1.003" "0.978" "0.991" "1.033" "1.015" "1.000" "1.016" "1.021" "0.999" "1762.4" "1767.5" "1724.1" "1746.3" "1820.3" "1789.0" "1762.7" "1791.0" "1799.0" "1760.0" "" "" "" "" "" "" "" "" "" "" "1651.4" "1462.6" "1600.6" "1350.0" "1551.6" "1709.2" "1610.6" "1590.2" "1799.0" "1694.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8925362845928829320" "False" "High" "IsMasterProtein" "Q12996" "Cleavage stimulation factor subunit 3 OS=Homo sapiens OX=9606 GN=CSTF3 PE=1 SV=1" "0.000" "False" "34.492" "16" "12" "15" "12" "717" "82.9" "8.12" "46.44" "12" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf05843" "1479" "ENSG00000176102" "CSTF3" "A8K471; D3DR04; E9PB40; hsa:1479; Q12996; Q32P22; Q96FQ8; Q96QD6; Q96QK4" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.029" "1.062" "1.071" "1.082" "1.111" "1.159" "1.227" "1.192" "1.100" "1659.6" "1707.1" "1762.2" "1777.8" "1795.3" "1843.4" "1924.1" "2036.7" "1977.9" "1826.3" "" "" "" "" "" "" "" "" "" "" "1555.0" "1412.6" "1636.0" "1374.3" "1530.3" "1761.2" "1758.1" "1808.4" "1977.9" "1758.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1985777424174479704" "False" "High" "IsMasterProtein" "Q14669" "E3 ubiquitin-protein ligase TRIP12 OS=Homo sapiens OX=9606 GN=TRIP12 PE=1 SV=1" "0.000" "False" "34.490" "6" "11" "13" "11" "1992" "220.3" "8.48" "40.16" "11" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00632" "9320" "ENSG00000153827" "TRIP12" "D4HL82; Q14669; Q14CA3; Q14CF1; Q15644; Q53R87; Q53TE7" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.072" "1.000" "1.091" "1.069" "1.046" "1.143" "1.102" "1.064" "1.084" "1335.0" "1431.0" "1334.8" "1457.0" "1427.6" "1396.5" "1525.9" "1471.0" "1420.8" "1447.5" "" "" "" "" "" "" "" "" "" "" "1250.9" "1184.1" "1239.2" "1126.3" "1216.8" "1334.3" "1394.3" "1306.1" "1420.8" "1393.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1520164082407222722" "False" "High" "IsMasterProtein" "P07737" "Profilin-1 OS=Homo sapiens OX=9606 GN=PFN1 PE=1 SV=2" "0.000" "False" "34.462" "60" "8" "49" "8" "140" "15.0" "8.27" "134.37" "8" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00235" "5216" "ENSG00000108518" "PFN1" "hsa:5216; P07737; Q53Y44" "Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Burn wound healing; Regulation of actin cytoskeleton; G13 signaling pathway" "RHO GTPases Activate Formins; Platelet degranulation ; PCP/CE pathway; Signaling by ROBO receptors" "9" "0" "1.074" "0.998" "1.089" "1.075" "1.002" "1.013" "1.011" "1.044" "1.002" "1459.5" "1567.4" "1457.3" "1589.2" "1569.3" "1461.9" "1478.6" "1475.4" "1524.2" "1462.3" "" "" "" "" "" "" "" "" "" "" "1367.6" "1297.0" "1352.9" "1228.5" "1337.6" "1396.7" "1351.1" "1310.0" "1524.2" "1408.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5978569898189539548" "False" "High" "IsMasterProtein" "O75694" "Nuclear pore complex protein Nup155 OS=Homo sapiens OX=9606 GN=NUP155 PE=1 SV=1" "0.000" "False" "34.455" "10" "12" "12" "12" "1391" "155.1" "6.16" "39.04" "12" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf08801" "9631" "ENSG00000113569" "NUP155" "hsa:9631; O75694; Q9UBE9; Q9UFL5" "" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "1.034" "1.074" "1.107" "1.112" "1.078" "1.083" "1.138" "1.083" "1.085" "979.3" "1013.0" "1051.9" "1084.0" "1089.4" "1055.7" "1061.1" "1114.3" "1060.8" "1062.9" "" "" "" "" "" "" "" "" "" "" "917.6" "838.3" "976.5" "838.0" "928.6" "1008.7" "969.5" "989.4" "1060.8" "1023.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6090154179084716209" "False" "High" "IsMasterProtein" "P36551" "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial OS=Homo sapiens OX=9606 GN=CPOX PE=1 SV=3" "0.000" "False" "34.382" "24" "9" "17" "9" "454" "50.1" "8.25" "54.99" "9" "other metabolic processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf01218" "1371" "ENSG00000080819" "CPOX" "A8K275; B4DSD5; hsa:1371; P36551; Q14060; Q53F08; Q8IZ45; Q96AF3" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "3" "0" "1.007" "1.010" "0.962" "0.999" "0.999" "0.943" "0.961" "0.989" "0.982" "1315.8" "1324.6" "1328.8" "1265.4" "1313.9" "1313.9" "1241.3" "1264.5" "1301.1" "1291.8" "" "" "" "" "" "" "" "" "" "" "1232.9" "1096.1" "1233.6" "978.2" "1120.0" "1255.3" "1134.2" "1122.8" "1301.1" "1243.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1393255483118757770" "False" "High" "IsMasterProtein" "Q9H2U2" "Inorganic pyrophosphatase 2, mitochondrial OS=Homo sapiens OX=9606 GN=PPA2 PE=1 SV=2" "0.000" "False" "34.375" "35" "10" "18" "9" "334" "37.9" "7.39" "55.20" "10" "other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00719" "27068" "ENSG00000138777" "PPA2" "B4DLP7; F8WDN9; hsa:27068; I6L9B6; Q4W5E9; Q6PG51; Q8TBW0; Q96E55; Q9H0T0; Q9H2U2; Q9NX37; Q9P033; Q9ULX0" "" "Mitochondrial tRNA aminoacylation; Pyrophosphate hydrolysis" "2" "0" "0.995" "1.036" "1.018" "1.082" "1.085" "1.020" "1.104" "1.042" "1.032" "916.5" "911.7" "949.4" "932.9" "991.5" "994.8" "935.1" "1012.1" "954.9" "946.0" "" "" "" "" "" "" "" "" "" "" "858.8" "754.5" "881.4" "721.2" "845.1" "950.4" "854.4" "898.7" "954.9" "910.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8439683798465219975" "False" "High" "IsMasterProtein" "P08621" "U1 small nuclear ribonucleoprotein 70 kDa OS=Homo sapiens OX=9606 GN=SNRNP70 PE=1 SV=2" "0.000" "False" "34.344" "24" "11" "16" "11" "437" "51.5" "9.94" "41.35" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf12220" "6625" "ENSG00000104852" "SNRNP70" "B3KUA3; hsa:6625; P08621; P78493; P78494; Q15364; Q15686; Q15687; Q15689; Q99377; Q9UE45; Q9UE46; Q9UE47; Q9UE48; Q9UFQ6" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.026" "1.087" "0.938" "0.885" "0.935" "0.952" "0.915" "0.974" "0.969" "1817.4" "1865.5" "1975.2" "1705.3" "1608.4" "1698.8" "1729.3" "1662.0" "1770.6" "1760.4" "" "" "" "" "" "" "" "" "" "" "1702.9" "1543.7" "1833.7" "1318.3" "1370.9" "1623.1" "1580.1" "1475.7" "1770.6" "1695.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5469246297971201094" "False" "High" "IsMasterProtein" "Q86TU7" "Actin-histidine N-methyltransferase OS=Homo sapiens OX=9606 GN=SETD3 PE=1 SV=1" "0.000" "False" "34.323" "20" "11" "14" "11" "594" "67.2" "5.96" "48.62" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00856, Pf09273" "84193" "ENSG00000183576" "SETD3" "A0PJU3; A5PLP0; B4DZE8; hsa:84193; Q0VAQ2; Q659C0; Q86TU7; Q86TU8; Q96GY9; Q9H5U5" "Histone modifications" "PKMTs methylate histone lysines" "2" "0" "1.011" "1.007" "1.003" "0.995" "0.996" "0.970" "0.970" "1.013" "1.017" "1465.9" "1481.7" "1476.1" "1470.0" "1458.3" "1459.7" "1422.2" "1422.1" "1485.1" "1491.2" "" "" "" "" "" "" "" "" "" "" "1373.6" "1226.1" "1370.4" "1136.4" "1243.0" "1394.6" "1299.5" "1262.7" "1485.1" "1435.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7656229856008546485" "False" "High" "IsMasterProtein" "O95453" "Poly(A)-specific ribonuclease PARN OS=Homo sapiens OX=9606 GN=PARN PE=1 SV=1" "0.000" "False" "34.318" "19" "12" "14" "12" "639" "73.4" "6.20" "47.23" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04857, Pf08675" "5073" "ENSG00000140694; ENSG00000274829" "PARN" "B2RCB3; B4DDG8; B4DSB0; B4DWR4; B4E1H6; hsa:5073; O95453" "Lung fibrosis" "Deadenylation of mRNA; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA" "4" "0" "0.957" "1.008" "1.014" "1.050" "1.026" "1.085" "1.071" "1.058" "1.048" "1494.1" "1430.4" "1506.0" "1514.8" "1569.1" "1532.5" "1620.5" "1600.0" "1581.1" "1565.6" "" "" "" "" "" "" "" "" "" "" "1400.0" "1183.7" "1398.2" "1171.0" "1337.5" "1464.2" "1480.7" "1420.7" "1581.1" "1507.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6708028902102911891" "False" "High" "IsMasterProtein" "P21281" "V-type proton ATPase subunit B, brain isoform OS=Homo sapiens OX=9606 GN=ATP6V1B2 PE=1 SV=3" "0.000" "False" "34.290" "24" "11" "16" "11" "511" "56.5" "5.81" "46.16" "11" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00006, Pf02874" "526" "ENSG00000147416" "ATP6V1B2" "B2R5Z3; D3DSQ5; hsa:526; P21281; Q14544; Q15859; Q96IR0" "" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "5" "0" "1.038" "1.016" "1.037" "0.964" "0.935" "0.953" "0.957" "1.101" "0.971" "1981.0" "2055.6" "2013.4" "2055.2" "1909.2" "1852.6" "1887.8" "1894.9" "2181.2" "1923.7" "" "" "" "" "" "" "" "" "" "" "1856.2" "1701.0" "1869.2" "1588.8" "1627.3" "1770.0" "1725.0" "1682.5" "2181.2" "1852.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2621085061721332365" "False" "High" "IsMasterProtein" "P48382" "DNA-binding protein RFX5 OS=Homo sapiens OX=9606 GN=RFX5 PE=1 SV=1" "0.000" "False" "34.289" "20" "12" "14" "11" "616" "65.3" "9.29" "41.00" "12" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257, Pf14621, Pf18326" "5993" "ENSG00000143390" "RFX5" "B7Z848; D3DV19; E9PFU4; hsa:5993; P48382; Q5VWC3" "Prion disease pathway; IL-18 signaling pathway" "" "2" "0" "0.969" "0.969" "1.009" "0.998" "0.994" "0.993" "0.972" "0.978" "0.981" "1523.5" "1476.8" "1476.0" "1537.0" "1520.7" "1513.8" "1512.3" "1481.5" "1490.2" "1494.7" "" "" "" "" "" "" "" "" "" "" "1427.5" "1222.1" "1370.3" "1188.2" "1296.2" "1446.3" "1381.8" "1315.4" "1490.2" "1439.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1394219767961209764" "False" "High" "IsMasterProtein" "Q5T5Y3" "Calmodulin-regulated spectrin-associated protein 1 OS=Homo sapiens OX=9606 GN=CAMSAP1 PE=1 SV=2" "0.000" "False" "34.287" "7" "11" "11" "11" "1602" "177.9" "6.73" "35.18" "11" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf08683, Pf11971, Pf17095" "157922" "ENSG00000130559" "CAMSAP1" "A1L4L2; B2REB2; B2REB3; hsa:157922; Q5T5Y3; Q70W33; Q8NCY0; Q96E80; Q96FM3; Q9UFJ5" "" "" "0" "0" "1.011" "0.991" "0.971" "1.050" "0.987" "0.990" "0.997" "1.004" "1.062" "1086.6" "1098.5" "1076.5" "1054.7" "1140.7" "1072.1" "1076.1" "1083.0" "1090.7" "1153.5" "" "" "" "" "" "" "" "" "" "" "1018.1" "909.0" "999.4" "815.3" "972.3" "1024.3" "983.3" "961.6" "1090.7" "1110.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8730523960052608716" "False" "High" "IsMasterProtein" "O60879" "Protein diaphanous homolog 2 OS=Homo sapiens OX=9606 GN=DIAPH2 PE=1 SV=1" "0.000" "False" "34.266" "10" "14" "16" "14" "1101" "125.5" "6.58" "45.43" "14" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02181, Pf06367, Pf06371" "1730" "ENSG00000147202" "DIAPH2" "A6NG19; hsa:1730; O60878; O60879; Q8WX06; Q8WX48; Q9UJL2" "Primary ovarian insufficiency" "RHOF GTPase cycle" "2" "0" "1.012" "1.009" "1.090" "1.065" "1.039" "1.052" "1.047" "1.003" "1.030" "1157.8" "1171.5" "1168.4" "1261.7" "1233.7" "1202.6" "1217.7" "1212.8" "1161.3" "1192.2" "" "" "" "" "" "" "" "" "" "" "1084.9" "969.4" "1084.7" "975.3" "1051.5" "1149.0" "1112.7" "1076.9" "1161.3" "1147.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6518875519697934580" "False" "High" "IsMasterProtein" "Q92576" "PHD finger protein 3 OS=Homo sapiens OX=9606 GN=PHF3 PE=1 SV=3" "0.000" "False" "34.222" "6" "13" "13" "13" "2039" "229.3" "6.96" "43.34" "13" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00628, Pf07500, Pf07744" "23469" "ENSG00000118482" "PHF3" "A3KFI8; hsa:23469; Q14CR5; Q5CZI1; Q5T1T6; Q92576; Q9NQ16; Q9UI45" "" "" "0" "0" "1.009" "1.046" "1.116" "1.113" "1.149" "1.199" "1.249" "1.171" "1.100" "1462.5" "1475.5" "1529.6" "1632.3" "1627.6" "1680.2" "1753.1" "1826.2" "1713.3" "1608.9" "" "" "" "" "" "" "" "" "" "" "1370.4" "1220.9" "1420.1" "1261.9" "1387.3" "1605.3" "1601.9" "1621.5" "1713.3" "1549.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3239366280692976916" "False" "High" "IsMasterProtein" "O14920" "Inhibitor of nuclear factor kappa-B kinase subunit beta OS=Homo sapiens OX=9606 GN=IKBKB PE=1 SV=1" "0.000" "False" "34.214" "17" "12" "14" "11" "756" "86.5" "5.78" "46.84" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf12179, Pf18397" "3551" "ENSG00000104365" "IKBKB" "B4DZ30; B4E0U4; hsa:3551; O14920; O75327" "Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; Apoptosis; Polycystic kidney disease pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Nonalcoholic fatty liver disease; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; Acute myeloid leukemia; T-cell receptor signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; PKR-mediated signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling" "91" "1" "1.042" "1.048" "1.011" "1.047" "1.044" "0.933" "0.995" "0.986" "1.002" "2085.8" "2174.4" "2185.2" "2109.4" "2183.6" "2177.9" "1947.1" "2075.3" "2057.5" "2090.5" "" "" "" "" "" "" "" "" "" "" "1954.4" "1799.3" "2028.7" "1630.6" "1861.3" "2080.8" "1779.1" "1842.6" "2057.5" "2012.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5766769550040713609" "False" "High" "IsMasterProtein" "Q9UHI6" "Probable ATP-dependent RNA helicase DDX20 OS=Homo sapiens OX=9606 GN=DDX20 PE=1 SV=2" "0.000" "False" "34.207" "14" "11" "13" "11" "824" "92.2" "6.95" "40.60" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "11218" "ENSG00000064703" "DDX20" "B4DWV7; hsa:11218; Q96F72; Q9NVM3; Q9UF59; Q9UHI6; Q9UIY0; Q9Y659" "mRNA processing; Male infertility" "SARS-CoV-2 modulates host translation machinery; snRNP Assembly" "4" "0" "1.073" "1.048" "1.125" "1.102" "1.065" "1.038" "1.005" "1.025" "1.058" "969.5" "1040.5" "1016.5" "1091.1" "1067.9" "1032.8" "1006.1" "973.9" "993.8" "1025.4" "" "" "" "" "" "" "" "" "" "" "908.4" "861.0" "943.7" "843.5" "910.3" "986.8" "919.3" "864.7" "993.8" "987.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4801012359298608333" "False" "High" "IsMasterProtein" "Q6L8Q7" "2',5'-phosphodiesterase 12 OS=Homo sapiens OX=9606 GN=PDE12 PE=1 SV=2" "0.000" "False" "34.179" "15" "9" "13" "9" "609" "67.3" "6.57" "39.11" "9" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf03372, Pf21171" "201626" "ENSG00000174840" "PDE12" "B4DTU8; hsa:201626; Q6L8Q7; Q8IYU3; Q8NDU2; Q8TE78" "Phosphodiesterases in neuronal function" "OAS antiviral response" "2" "0" "1.093" "1.038" "1.037" "1.072" "1.041" "0.997" "1.039" "1.069" "1.074" "543.6" "594.0" "564.3" "563.8" "582.6" "566.2" "542.1" "564.6" "581.0" "583.8" "" "" "" "" "" "" "" "" "" "" "509.4" "491.6" "523.9" "435.8" "496.6" "540.9" "495.3" "501.3" "581.0" "562.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3450396974392384393" "False" "High" "IsMasterProtein" "Q13112" "Chromatin assembly factor 1 subunit B OS=Homo sapiens OX=9606 GN=CHAF1B PE=1 SV=1" "0.000" "False" "34.175" "23" "12" "13" "12" "559" "61.5" "7.50" "47.35" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf00400, Pf15512" "8208" "ENSG00000159259" "CHAF1B" "hsa:8208; Q13112; Q99548" "" "" "0" "0" "0.902" "1.021" "0.997" "0.993" "0.984" "0.978" "0.992" "0.970" "0.996" "2322.3" "2094.3" "2371.0" "2314.6" "2306.1" "2284.1" "2271.6" "2303.5" "2253.8" "2313.5" "" "" "" "" "" "" "" "" "" "" "2176.0" "1733.0" "2201.1" "1789.3" "1965.6" "2182.2" "2075.7" "2045.3" "2253.8" "2227.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7059158695698353069" "False" "High" "IsMasterProtein" "Q9H0U4" "Ras-related protein Rab-1B OS=Homo sapiens OX=9606 GN=RAB1B PE=1 SV=1" "0.000" "False" "34.169" "54" "10" "17" "3" "201" "22.2" "5.73" "58.27" "10" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "81876" "ENSG00000174903" "RAB1B" "A8K7S1; hsa:81876; Q9H0U4" "" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization" "6" "4" "0.926" "1.008" "0.874" "0.910" "0.947" "0.966" "0.964" "0.941" "0.930" "1454.5" "1346.2" "1466.2" "1271.9" "1323.2" "1377.2" "1404.7" "1402.7" "1369.1" "1353.2" "" "" "" "" "" "" "" "" "" "" "1362.8" "1113.9" "1361.2" "983.2" "1127.8" "1315.8" "1283.5" "1245.4" "1369.1" "1302.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2473277628257978921" "False" "High" "IsMasterProtein" "Q5SRE5" "Nucleoporin NUP188 OS=Homo sapiens OX=9606 GN=NUP188 PE=1 SV=1" "0.000" "False" "34.126" "7" "13" "16" "13" "1749" "195.9" "6.73" "39.87" "13" "transport" "cytosol;nucleus" "other molecular function" "Pf10487, Pf21093, Pf21094" "23511" "ENSG00000095319" "NUP188" "hsa:23511; Q14675; Q2TA87; Q5SRE5; Q7Z3K8; Q8IWF1" "" "Vpr-mediated nuclear import of PICs; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; SUMOylation of chromatin organization proteins; HCMV Early Events; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "0.968" "1.022" "1.003" "1.060" "1.099" "1.044" "1.083" "1.078" "1.066" "1055.0" "1021.6" "1078.5" "1058.3" "1118.3" "1159.7" "1101.6" "1142.4" "1136.9" "1124.5" "" "" "" "" "" "" "" "" "" "" "988.5" "845.4" "1001.2" "818.1" "953.2" "1108.0" "1006.5" "1014.4" "1136.9" "1082.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "997292728151378108" "False" "High" "IsMasterProtein" "P32519" "ETS-related transcription factor Elf-1 OS=Homo sapiens OX=9606 GN=ELF1 PE=1 SV=2" "0.000" "False" "34.093" "24" "10" "14" "10" "619" "67.5" "5.21" "57.83" "10" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf12310" "1997" "ENSG00000120690" "ELF1" "B4E2I5; E9PDQ9; hsa:1997; P32519; Q8N6F6; Q9UDE1" "" "RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX1 regulates transcription of genes involved in BCR signaling" "2" "0" "0.967" "0.992" "1.050" "1.005" "1.013" "0.993" "0.949" "0.969" "1.009" "1854.3" "1793.1" "1840.0" "1946.6" "1864.2" "1878.4" "1840.5" "1759.6" "1796.0" "1871.4" "" "" "" "" "" "" "" "" "" "" "1737.4" "1483.8" "1708.2" "1504.8" "1589.0" "1794.6" "1681.7" "1562.4" "1796.0" "1801.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1595519607435168922" "False" "High" "IsMasterProtein" "P31942" "Heterogeneous nuclear ribonucleoprotein H3 OS=Homo sapiens OX=9606 GN=HNRNPH3 PE=1 SV=2" "0.000" "False" "34.080" "32" "9" "17" "8" "346" "36.9" "6.87" "55.71" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00076" "3189" "ENSG00000096746" "HNRNPH3" "A8K682; B3KRE1; hsa:3189; P31942; Q9BSX1; Q9NP53; Q9NP96; Q9NPA7; Q9NPI4; Q9UFU4; Q9Y4J5" "" "" "0" "0" "1.204" "1.101" "1.137" "1.103" "1.133" "1.076" "1.081" "1.136" "1.170" "327.7" "394.7" "360.9" "372.7" "361.6" "371.2" "352.5" "354.3" "372.4" "383.5" "" "" "" "" "" "" "" "" "" "" "307.1" "326.6" "335.1" "288.1" "308.2" "354.6" "322.1" "314.5" "372.4" "369.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2552145293122951673" "False" "High" "IsMasterProtein" "Q96P48" "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ARAP1 PE=1 SV=3" "0.000" "False" "34.053" "9" "13" "13" "13" "1450" "162.1" "6.23" "37.71" "13" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00169, Pf00536, Pf00620, Pf00788, Pf01412" "116985" "ENSG00000186635" "ARAP1" "A3KLL7; B2RTS2; hsa:116985; O94879; Q4LDD5; Q59FI7; Q6PHS3; Q8WU51; Q96HP6; Q96L71; Q96P48" "" "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; RHOA GTPase cycle; RAC1 GTPase cycle; CDC42 GTPase cycle" "4" "0" "1.017" "1.022" "1.100" "1.057" "0.978" "1.031" "0.997" "1.031" "1.066" "514.9" "523.6" "526.1" "566.2" "544.2" "503.8" "531.0" "513.5" "531.1" "549.2" "" "" "" "" "" "" "" "" "" "" "482.5" "433.3" "488.5" "437.7" "463.9" "481.3" "485.2" "455.9" "531.1" "528.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7590147556392166876" "False" "High" "IsMasterProtein" "P07384" "Calpain-1 catalytic subunit OS=Homo sapiens OX=9606 GN=CAPN1 PE=1 SV=1" "0.000" "False" "33.978" "16" "11" "15" "11" "714" "81.8" "5.67" "48.72" "11" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00648, Pf01067, Pf13833" "823" "ENSG00000014216" "CAPN1" "P07384; Q2TTR0; Q6DHV4" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Formation of the cornified envelope; Degradation of the extracellular matrix; Neutrophil degranulation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "7" "0" "1.044" "0.994" "0.970" "0.989" "1.048" "0.967" "0.957" "0.972" "1.034" "1262.5" "1318.5" "1254.4" "1224.4" "1248.6" "1323.0" "1220.8" "1208.6" "1227.5" "1305.9" "" "" "" "" "" "" "" "" "" "" "1182.9" "1091.1" "1164.5" "946.5" "1064.3" "1264.0" "1115.5" "1073.1" "1227.5" "1257.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2487901490658103836" "False" "High" "IsMasterProtein" "O75995" "SAM and SH3 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=SASH3 PE=1 SV=2" "0.000" "False" "33.975" "33" "8" "19" "8" "380" "41.6" "5.27" "77.25" "8" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "" "Pf00536, Pf07653, Pf12485" "54440" "ENSG00000122122" "SASH3" "A6NCH1; A8K7K8; hsa:54440; O75995; Q5JZ38" "" "" "0" "0" "0.992" "1.007" "0.969" "1.057" "1.065" "0.972" "1.037" "1.032" "1.026" "1090.9" "1082.4" "1098.8" "1057.0" "1153.0" "1162.0" "1060.8" "1131.6" "1126.2" "1119.3" "" "" "" "" "" "" "" "" "" "" "1022.2" "895.6" "1020.1" "817.1" "982.8" "1110.1" "969.3" "1004.7" "1126.2" "1077.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-912573818931081677" "False" "High" "IsMasterProtein" "P48736" "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform OS=Homo sapiens OX=9606 GN=PIK3CG PE=1 SV=3" "0.000" "False" "33.930" "11" "13" "15" "13" "1102" "126.4" "7.50" "45.88" "13" "cell adhesion;cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792, Pf00794, Pf19710" "5294" "ENSG00000105851" "PIK3CG" "A4D0Q6; hsa:5294; P48736; Q8IV23; Q9BZC8" "IL-5 signaling pathway; AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Prolactin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; BDNF-TrkB signaling; Amplification and expansion of oncogenic pathways as metastatic traits; Physico-chemical features and toxicity-associated pathways; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; Microglia pathogen phagocytosis pathway; PI3K-Akt signaling pathway; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; Osteoblast differentiation and related diseases; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Prostaglandin signaling; Opioid receptor pathways; Regulation of actin cytoskeleton; EPO receptor signaling; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "Synthesis of PIPs at the plasma membrane; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); GPVI-mediated activation cascade; G beta:gamma signalling through PI3Kgamma; Signaling by CSF1 (M-CSF) in myeloid cells" "40" "0" "0.952" "1.001" "1.019" "1.022" "1.016" "1.104" "0.954" "0.964" "1.020" "1042.1" "992.0" "1043.0" "1062.3" "1064.6" "1058.5" "1150.3" "993.7" "1004.3" "1062.6" "" "" "" "" "" "" "" "" "" "" "976.5" "820.9" "968.3" "821.2" "907.5" "1011.3" "1051.1" "882.3" "1004.3" "1023.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4076214252454433299" "False" "High" "IsMasterProtein" "Q969G3" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 OS=Homo sapiens OX=9606 GN=SMARCE1 PE=1 SV=2" "0.000" "False" "33.928" "30" "11" "14" "11" "411" "46.6" "4.88" "40.19" "11" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505" "6605" "ENSG00000073584" "SMARCE1" "B3KMC1; B4DFR4; C0IMW4; C0IMW5; C0IMW7; H7C3F6; hsa:6605; O43539; Q969G3" "Androgen receptor signaling pathway; Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "6" "0" "1.028" "1.000" "0.989" "1.026" "1.035" "1.030" "1.045" "0.992" "1.056" "1637.8" "1683.9" "1637.8" "1619.5" "1680.3" "1695.5" "1687.2" "1711.5" "1624.1" "1729.3" "" "" "" "" "" "" "" "" "" "" "1534.6" "1393.4" "1520.5" "1252.0" "1432.3" "1619.9" "1541.6" "1519.6" "1624.1" "1665.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2350486907516670884" "False" "High" "IsMasterProtein" "Q7Z5K2" "Wings apart-like protein homolog OS=Homo sapiens OX=9606 GN=WAPL PE=1 SV=1" "0.000" "False" "33.864" "12" "13" "14" "13" "1190" "132.9" "5.44" "38.79" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07814" "23063" "ENSG00000062650" "WAPL" "A7E2B5; hsa:23063; Q5VSK5; Q7Z5K2; Q8IX10; Q92549" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "6" "0" "0.972" "1.002" "1.008" "0.985" "0.975" "0.957" "0.905" "0.898" "0.969" "1342.2" "1304.5" "1344.3" "1352.5" "1322.6" "1308.7" "1285.0" "1214.9" "1205.2" "1301.0" "" "" "" "" "" "" "" "" "" "" "1257.7" "1079.4" "1248.0" "1045.6" "1127.3" "1250.4" "1174.2" "1078.7" "1205.2" "1252.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3944775931209301438" "False" "High" "IsMasterProtein" "P60660" "Myosin light polypeptide 6 OS=Homo sapiens OX=9606 GN=MYL6 PE=1 SV=2" "0.000" "False" "33.859" "50" "8" "17" "6" "151" "16.9" "4.65" "52.68" "8" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "" "4637" "ENSG00000092841" "MYL6" "hsa:4637; P16475; P24572; P24573; P60660; Q12790; Q561V9; Q6IAZ0; Q6IPY5" "Ciliary landscape" "RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "8" "2" "1.067" "1.046" "1.071" "1.024" "0.951" "0.968" "0.937" "0.932" "0.967" "2847.9" "3040.1" "2978.3" "3049.3" "2915.2" "2707.3" "2756.8" "2667.3" "2654.8" "2754.6" "" "" "" "" "" "" "" "" "" "" "2668.4" "2515.6" "2765.0" "2357.3" "2484.9" "2586.6" "2518.9" "2368.3" "2654.8" "2652.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1079834079423301401" "False" "High" "IsMasterProtein" "Q8TD19" "Serine/threonine-protein kinase Nek9 OS=Homo sapiens OX=9606 GN=NEK9 PE=1 SV=2" "0.000" "False" "33.842" "13" "11" "17" "11" "979" "107.1" "5.74" "46.26" "11" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00415, Pf13540" "91754" "ENSG00000119638" "NEK9" "hsa:91754; Q52LK6; Q8NCN0; Q8TCY4; Q8TD19; Q9UPI4; Q9Y6S4; Q9Y6S5; Q9Y6S6" "Ciliopathies" "EML4 and NUDC in mitotic spindle formation; Nuclear Pore Complex (NPC) Disassembly; Activation of NIMA Kinases NEK9, NEK6, NEK7" "4" "0" "0.985" "0.984" "1.015" "1.020" "0.993" "0.960" "0.957" "1.000" "1.028" "1512.3" "1489.0" "1488.8" "1534.4" "1542.6" "1502.1" "1452.4" "1447.3" "1511.6" "1554.6" "" "" "" "" "" "" "" "" "" "" "1417.0" "1232.1" "1382.2" "1186.1" "1314.9" "1435.1" "1327.1" "1285.1" "1511.6" "1496.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1901322686263979467" "False" "High" "IsMasterProtein" "Q32P44" "Echinoderm microtubule-associated protein-like 3 OS=Homo sapiens OX=9606 GN=EML3 PE=1 SV=1" "0.000" "False" "33.796" "12" "10" "10" "10" "896" "95.1" "7.12" "40.99" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451" "256364" "ENSG00000149499" "EML3" "hsa:256364; Q32P44; Q6ZQW7; Q8NA55" "" "" "0" "0" "0.983" "1.019" "1.011" "1.037" "1.003" "0.969" "0.974" "1.018" "1.028" "1063.3" "1045.3" "1084.0" "1074.8" "1102.6" "1066.5" "1029.9" "1036.2" "1082.3" "1093.2" "" "" "" "" "" "" "" "" "" "" "996.3" "865.0" "1006.3" "830.8" "939.9" "1019.0" "941.1" "920.0" "1082.3" "1052.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6282846472165231546" "False" "High" "IsMasterProtein" "Q9P289" "Serine/threonine-protein kinase 26 OS=Homo sapiens OX=9606 GN=STK26 PE=1 SV=2" "0.000" "False" "33.789" "31" "12" "20" "6" "416" "46.5" "5.29" "51.18" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "51765" "ENSG00000134602" "STK26" "B2RAU2; hsa:51765; Q3ZB77; Q8NC04; Q9BXC3; Q9BXC4; Q9P289" "" "Apoptotic cleavage of cellular proteins" "1" "4" "0.964" "0.983" "1.005" "0.992" "0.977" "0.940" "0.966" "0.967" "0.995" "3346.0" "3227.0" "3288.3" "3361.6" "3319.7" "3269.0" "3145.6" "3233.4" "3234.5" "3329.2" "" "" "" "" "" "" "" "" "" "" "3135.2" "2670.3" "3052.8" "2598.7" "2829.6" "3123.2" "2874.2" "2870.9" "3234.5" "3205.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7253720687934924150" "False" "High" "IsMasterProtein" "P19525" "Interferon-induced, double-stranded RNA-activated protein kinase OS=Homo sapiens OX=9606 GN=EIF2AK2 PE=1 SV=2" "0.000" "False" "33.785" "17" "9" "21" "9" "551" "62.1" "8.40" "58.38" "9" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00035, Pf00069" "5610" "ENSG00000055332" "EIF2AK2" "A8K3P0; D6W584; E9PC80; hsa:5610; P19525; Q52M43; Q7Z6F6; Q9UIR4" "Translation factors; Alzheimer's disease and miRNA effects; PDGFR-beta pathway; Ebola virus infection in host; Measles virus infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Alzheimer's disease; Roles of ceramides in development of insulin resistance; Type II interferon signaling" "ISG15 antiviral mechanism; PKR-mediated signaling; Interferon alpha/beta signaling; Evasion by RSV of host interferon responses; Inhibition of PKR; SUMOylation of immune response proteins" "16" "0" "0.979" "1.020" "1.016" "1.019" "1.053" "1.013" "0.989" "1.046" "1.012" "2129.4" "2084.5" "2171.4" "2163.7" "2169.7" "2243.1" "2157.1" "2105.6" "2228.3" "2155.6" "" "" "" "" "" "" "" "" "" "" "1995.3" "1724.9" "2015.8" "1672.6" "1849.4" "2143.1" "1971.0" "1869.6" "2228.3" "2075.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1650974207865814862" "False" "High" "IsMasterProtein" "P04818" "Thymidylate synthase OS=Homo sapiens OX=9606 GN=TYMS PE=1 SV=3" "0.000" "False" "33.775" "30" "9" "17" "9" "313" "35.7" "7.01" "57.29" "9" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00303" "7298" "ENSG00000176890" "TYMS" "hsa:7298; P04818; Q8WYK3; Q8WYK4" "Fluoropyrimidine activity; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription" "9" "0" "1.030" "1.060" "1.061" "1.012" "1.029" "1.016" "0.977" "0.993" "1.037" "1183.2" "1218.4" "1253.6" "1255.6" "1197.4" "1217.0" "1202.1" "1155.9" "1174.9" "1226.5" "" "" "" "" "" "" "" "" "" "" "1108.6" "1008.2" "1163.8" "970.7" "1020.6" "1162.8" "1098.4" "1026.3" "1174.9" "1181.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5004824679755995217" "False" "High" "IsMasterProtein" "Q13867" "Bleomycin hydrolase OS=Homo sapiens OX=9606 GN=BLMH PE=1 SV=1" "0.000" "False" "33.722" "23" "10" "20" "10" "455" "52.5" "6.27" "63.20" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf03051" "642" "ENSG00000108578" "BLMH" "B2R796; hsa:642; Q13867; Q53F86; Q9UER9" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.976" "0.942" "1.006" "0.918" "0.978" "0.935" "0.942" "0.938" "0.927" "2938.8" "2869.5" "2768.4" "2956.2" "2699.3" "2875.5" "2747.4" "2768.5" "2757.5" "2725.3" "" "" "" "" "" "" "" "" "" "" "2753.7" "2374.5" "2570.1" "2285.3" "2300.8" "2747.2" "2510.4" "2458.1" "2757.5" "2624.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3647581331953333811" "False" "High" "IsMasterProtein" "Q658Y4" "Protein FAM91A1 OS=Homo sapiens OX=9606 GN=FAM91A1 PE=1 SV=3" "0.000" "False" "33.660" "14" "13" "19" "13" "838" "93.9" "6.39" "56.77" "13" "cell organization and biogenesis;transport" "ER/Golgi;other cell component" "" "Pf14647, Pf14648" "157769" "ENSG00000176853" "FAM91A1" "B6YY23; hsa:157769; Q658T5; Q658Y4; Q8TE89" "Gastric cancer network 2" "RHOH GTPase cycle" "2" "0" "0.963" "0.985" "0.975" "0.989" "0.988" "0.952" "0.940" "0.953" "0.939" "1905.7" "1835.7" "1876.9" "1857.6" "1884.3" "1882.5" "1813.9" "1790.9" "1816.8" "1789.8" "" "" "" "" "" "" "" "" "" "" "1785.7" "1519.0" "1742.4" "1436.0" "1606.1" "1798.5" "1657.4" "1590.1" "1816.8" "1723.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5626917880360896955" "False" "High" "IsMasterProtein" "Q8N201" "Integrator complex subunit 1 OS=Homo sapiens OX=9606 GN=INTS1 PE=1 SV=2" "0.000" "False" "33.578" "5" "11" "11" "11" "2190" "244.1" "6.13" "34.22" "11" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;nucleus" "" "Pf12432" "26173" "ENSG00000164880" "INTS1" "A6NJ44; hsa:26173; Q6NT70; Q6UX74; Q8N201; Q8WV40; Q96D36; Q9NTD1; Q9P2A8; Q9Y3W8" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "0.995" "1.077" "1.096" "0.994" "1.026" "1.049" "1.011" "0.982" "1.008" "745.5" "742.1" "802.8" "817.3" "741.2" "765.0" "781.8" "753.8" "731.8" "751.4" "" "" "" "" "" "" "" "" "" "" "698.6" "614.1" "745.3" "631.8" "631.8" "730.9" "714.4" "669.3" "731.8" "723.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2351772574129659372" "False" "High" "IsMasterProtein" "P35269" "General transcription factor IIF subunit 1 OS=Homo sapiens OX=9606 GN=GTF2F1 PE=1 SV=2" "0.000" "False" "33.562" "24" "9" "12" "9" "517" "58.2" "7.49" "50.33" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf05793" "2962" "ENSG00000125651" "GTF2F1" "B2RCS0; hsa:2962; P35269; Q9BWN0" "" "Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Estrogen-dependent gene expression; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "32" "0" "1.034" "1.022" "0.951" "1.033" "1.038" "0.980" "1.072" "1.031" "1.027" "2014.5" "2082.8" "2059.2" "1916.6" "2080.0" "2091.4" "1974.5" "2159.2" "2077.3" "2069.4" "" "" "" "" "" "" "" "" "" "" "1887.6" "1723.5" "1911.8" "1481.6" "1772.9" "1998.2" "1804.2" "1917.1" "2077.3" "1992.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3028893805167112372" "False" "High" "IsMasterProtein" "O75351" "Vacuolar protein sorting-associated protein 4B OS=Homo sapiens OX=9606 GN=VPS4B PE=1 SV=2" "0.000" "False" "33.515" "25" "12" "15" "7" "444" "49.3" "7.23" "44.28" "12" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00004, Pf04212, Pf09336, Pf17862" "9525" "ENSG00000119541" "VPS4B" "hsa:9525; O75351; Q69HW4; Q9GZS7" "" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "2" "2" "0.922" "0.964" "0.943" "0.993" "1.029" "0.963" "0.966" "0.924" "0.976" "2399.7" "2213.1" "2314.1" "2262.6" "2382.9" "2470.1" "2310.0" "2318.4" "2216.6" "2342.9" "" "" "" "" "" "" "" "" "" "" "2248.5" "1831.4" "2148.3" "1749.1" "2031.1" "2359.9" "2110.8" "2058.5" "2216.6" "2255.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2190744193783032342" "False" "High" "IsMasterProtein" "Q92619" "Rho GTPase-activating protein 45 OS=Homo sapiens OX=9606 GN=ARHGAP45 PE=1 SV=2" "0.000" "False" "33.479" "10" "11" "16" "11" "1136" "124.5" "6.10" "41.70" "11" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00620" "23526" "ENSG00000180448" "ARHGAP45" "B4DTS4; F6QP70; hsa:23526; Q6P189; Q7LE26; Q86WS1; Q8HX84; Q92619; Q9GJN9; Q9GJP0; Q9GJP1; Q9MY24" "" "Neutrophil degranulation; RAC1 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle" "4" "0" "0.939" "0.978" "0.925" "0.916" "1.011" "0.894" "0.916" "0.936" "0.983" "1091.3" "1024.9" "1066.9" "1009.8" "999.8" "1102.9" "975.5" "999.6" "1021.5" "1073.0" "" "" "" "" "" "" "" "" "" "" "1022.6" "848.1" "990.5" "780.6" "852.2" "1053.7" "891.3" "887.6" "1021.5" "1033.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7322766248926009386" "False" "High" "IsMasterProtein" "Q13564" "NEDD8-activating enzyme E1 regulatory subunit OS=Homo sapiens OX=9606 GN=NAE1 PE=1 SV=1" "0.000" "False" "33.470" "26" "10" "16" "10" "534" "60.2" "5.40" "53.46" "10" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00899" "8883" "ENSG00000159593" "NAE1" "A6NCK0; A6NFN4; A8MU28; B2R700; B3KUP9; hsa:8883; Q13564" "Alzheimer's disease and miRNA effects; Hijack of ubiquitination by SARS-CoV-2; Alzheimer's disease" "Neddylation" "4" "0" "0.967" "1.079" "1.028" "1.062" "1.067" "1.007" "1.064" "1.086" "1.081" "875.6" "846.8" "945.2" "900.4" "930.4" "934.3" "881.6" "931.6" "951.0" "946.7" "" "" "" "" "" "" "" "" "" "" "820.5" "700.8" "877.5" "696.1" "793.0" "892.6" "805.5" "827.2" "951.0" "911.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "906200433272310872" "False" "High" "IsMasterProtein" "Q8NBS9" "Thioredoxin domain-containing protein 5 OS=Homo sapiens OX=9606 GN=TXNDC5 PE=1 SV=2" "0.000" "False" "33.431" "26" "10" "17" "10" "432" "47.6" "5.97" "44.66" "10" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00085" "81567" "ENSG00000239264" "TXNDC5" "B2RDM2; hsa:81567; Q5TCQ0; Q8NBS9; Q8ND33; Q8TCT2; Q9BVH9" "VEGFA-VEGFR2 signaling" "Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis; Neutrophil degranulation" "4" "0" "1.027" "0.973" "0.941" "0.942" "0.966" "0.877" "0.926" "0.878" "0.908" "2136.2" "2194.2" "2078.2" "2010.5" "2012.2" "2063.4" "1873.9" "1978.1" "1876.7" "1940.2" "" "" "" "" "" "" "" "" "" "" "2001.6" "1815.7" "1929.4" "1554.2" "1715.1" "1971.4" "1712.3" "1756.4" "1876.7" "1868.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200158126373336546" "False" "High" "IsMasterProtein" "Q6IBS0" "Twinfilin-2 OS=Homo sapiens OX=9606 GN=TWF2 PE=1 SV=2" "0.000" "False" "33.360" "28" "8" "17" "7" "349" "39.5" "6.84" "59.73" "8" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "11344" "ENSG00000247596" "TWF2" "hsa:11344; Q6IBS0; Q9Y3F5" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "2" "1" "0.873" "1.007" "0.919" "0.918" "0.912" "0.905" "0.938" "0.933" "0.933" "1639.5" "1430.5" "1650.3" "1505.9" "1504.4" "1496.0" "1483.1" "1537.5" "1529.6" "1529.3" "" "" "" "" "" "" "" "" "" "" "1536.2" "1183.8" "1532.1" "1164.1" "1282.3" "1429.3" "1355.1" "1365.2" "1529.6" "1472.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "741210737454912212" "False" "High" "IsMasterProtein" "Q7Z7A4" "PX domain-containing protein kinase-like protein OS=Homo sapiens OX=9606 GN=PXK PE=1 SV=1" "0.000" "False" "33.314" "15" "9" "15" "9" "578" "64.9" "9.35" "50.75" "9" "stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00787, Pf02205" "54899" "ENSG00000168297" "PXK" "hsa:54899; Q3BCH4; Q3BCH5; Q3BCH6; Q3BDW1; Q45L83; Q59EX3; Q6PK17; Q6ZN39; Q7Z7A4; Q96CA3; Q96R07; Q9NXB8" "" "" "0" "0" "0.987" "0.986" "1.015" "0.948" "0.921" "0.948" "0.940" "0.900" "0.929" "2049.7" "2023.4" "2020.1" "2079.7" "1943.0" "1888.7" "1943.4" "1927.6" "1845.5" "1905.0" "" "" "" "" "" "" "" "" "" "" "1920.6" "1674.3" "1875.4" "1607.7" "1656.1" "1804.5" "1775.8" "1711.6" "1845.5" "1834.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7003283534467846840" "False" "High" "IsMasterProtein" "P40937" "Replication factor C subunit 5 OS=Homo sapiens OX=9606 GN=RFC5 PE=1 SV=1" "0.000" "False" "33.299" "36" "12" "19" "12" "340" "38.5" "7.20" "53.46" "12" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5985" "ENSG00000111445" "RFC5" "A8MZ62; B3KSX8; hsa:5985; P40937" "Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "HDR through Homologous Recombination (HRR); Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "28" "0" "1.062" "1.012" "1.066" "1.022" "1.030" "1.024" "0.973" "1.067" "1.025" "2608.6" "2770.5" "2640.8" "2780.1" "2667.2" "2685.5" "2670.9" "2538.0" "2783.3" "2674.9" "" "" "" "" "" "" "" "" "" "" "2444.2" "2292.6" "2451.7" "2149.1" "2273.4" "2565.8" "2440.5" "2253.5" "2783.3" "2575.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3583580330514197896" "False" "High" "IsMasterProtein" "P55809" "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=OXCT1 PE=1 SV=1" "0.000" "False" "33.298" "25" "11" "18" "11" "520" "56.1" "7.46" "56.16" "11" "other metabolic processes" "mitochondrion" "other molecular function" "Pf01144" "5019" "ENSG00000083720" "OXCT1" "B2R5V2; B7Z528; hsa:5019; P55809" "" "Mitochondrial protein degradation; Utilization of Ketone Bodies" "2" "0" "0.986" "0.995" "0.972" "1.016" "0.995" "0.944" "1.006" "1.037" "1.000" "1696.3" "1671.9" "1687.0" "1649.4" "1723.4" "1688.5" "1602.0" "1707.0" "1759.1" "1695.6" "" "" "" "" "" "" "" "" "" "" "1589.4" "1383.4" "1566.2" "1275.1" "1469.0" "1613.2" "1463.8" "1515.6" "1759.1" "1632.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6056381579766233841" "False" "High" "IsMasterProtein" "Q9UNH7" "Sorting nexin-6 OS=Homo sapiens OX=9606 GN=SNX6 PE=1 SV=1" "0.000" "False" "33.279" "21" "10" "16" "9" "406" "46.6" "6.16" "49.02" "10" "transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00787, Pf09325" "58533" "ENSG00000129515" "SNX6" "C0H5W9; hsa:58533; Q9UNH7; Q9Y449" "" "" "0" "0" "0.930" "0.952" "0.927" "0.975" "0.919" "0.922" "0.925" "0.837" "0.815" "2928.4" "2724.8" "2786.5" "2714.3" "2855.1" "2691.1" "2700.7" "2709.6" "2451.4" "2386.5" "" "" "" "" "" "" "" "" "" "" "2743.9" "2254.8" "2586.9" "2098.3" "2433.6" "2571.1" "2467.7" "2405.9" "2451.4" "2297.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5286637805257654056" "False" "High" "IsMasterProtein" "Q9BQG0" "Myb-binding protein 1A OS=Homo sapiens OX=9606 GN=MYBBP1A PE=1 SV=2" "0.000" "False" "33.247" "9" "13" "17" "13" "1328" "148.8" "9.28" "47.04" "13" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04931" "10514" "ENSG00000132382" "MYBBP1A" "hsa:10514; Q86VM3; Q9BQG0; Q9BW49; Q9P0V5; Q9UF99" "Energy metabolism; 10q11.21q11.23 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression" "3" "0" "0.989" "1.013" "1.006" "1.073" "1.017" "0.998" "1.026" "0.980" "1.067" "1646.7" "1628.5" "1667.9" "1656.0" "1767.3" "1674.6" "1643.4" "1688.7" "1613.7" "1757.0" "" "" "" "" "" "" "" "" "" "" "1542.9" "1347.6" "1548.5" "1280.2" "1506.4" "1599.9" "1501.7" "1499.4" "1613.7" "1691.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1585168671336988915" "False" "High" "IsMasterProtein" "Q01433" "AMP deaminase 2 OS=Homo sapiens OX=9606 GN=AMPD2 PE=1 SV=3" "0.000" "False" "33.234" "14" "12" "13" "12" "825" "94.8" "6.55" "38.23" "12" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf19326" "271" "ENSG00000116337" "AMPD2" "A0A5F9UK94; B4DK50; B4DZI5; E9PNG0; hsa:271; Q01433; Q14856; Q14857; Q16686; Q16687; Q16688; Q16729; Q5T693; Q5T695; Q96IA1; Q9UDX8; Q9UDX9; Q9UMU4" "" "Purine salvage" "1" "0" "1.069" "1.010" "1.202" "1.054" "0.941" "1.096" "1.010" "0.974" "0.998" "1226.2" "1311.0" "1238.8" "1473.9" "1292.2" "1153.3" "1343.6" "1238.8" "1194.5" "1224.0" "" "" "" "" "" "" "" "" "" "" "1148.9" "1084.8" "1150.0" "1139.4" "1101.4" "1101.9" "1227.7" "1099.9" "1194.5" "1178.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7162742285351111146" "False" "High" "IsMasterProtein" "Q13330" "Metastasis-associated protein MTA1 OS=Homo sapiens OX=9606 GN=MTA1 PE=1 SV=2" "0.000" "False" "33.192" "15" "11" "14" "9" "715" "80.7" "9.26" "43.62" "11" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "9112" "ENSG00000182979" "MTA1" "A5PLK4; hsa:9112; Q13330; Q86SW2; Q8NFI8; Q96GI8" "Effect of progerin on genes involved in progeria; TAR syndrome" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; SUMOylation of transcription factors" "8" "0" "1.018" "1.048" "0.975" "0.963" "0.951" "1.025" "0.962" "1.024" "0.998" "1485.5" "1511.6" "1557.5" "1449.1" "1429.9" "1412.7" "1522.8" "1429.6" "1521.8" "1483.1" "" "" "" "" "" "" "" "" "" "" "1391.9" "1250.8" "1445.9" "1120.2" "1218.8" "1349.7" "1391.4" "1269.3" "1521.8" "1428.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3579121838691215902" "False" "High" "IsMasterProtein" "Q7Z6I6" "Rho GTPase-activating protein 30 OS=Homo sapiens OX=9606 GN=ARHGAP30 PE=1 SV=3" "0.000" "False" "33.160" "10" "11" "14" "11" "1101" "118.5" "4.81" "41.41" "11" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00620" "257106" "ENSG00000186517" "ARHGAP30" "hsa:257106; Q5SY52; Q5SY53; Q5SY54; Q6ZML6; Q7Z3J8; Q7Z6I6; Q86XI7" "" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOU GTPase cycle" "4" "0" "1.058" "1.021" "1.077" "1.046" "1.041" "1.043" "1.033" "0.993" "1.021" "1189.9" "1259.1" "1214.4" "1281.5" "1245.0" "1238.3" "1241.4" "1229.6" "1181.4" "1214.6" "" "" "" "" "" "" "" "" "" "" "1114.9" "1041.8" "1127.4" "990.7" "1061.2" "1183.1" "1134.3" "1091.7" "1181.4" "1169.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "240711896831941506" "False" "High" "IsMasterProtein" "P23396" "Small ribosomal subunit protein uS3 OS=Homo sapiens OX=9606 GN=RPS3 PE=1 SV=2" "0.000" "False" "33.104" "43" "11" "18" "11" "243" "26.7" "9.66" "53.89" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00189, Pf07650" "6188" "ENSG00000149273" "RPS3" "B2R7N5; hsa:6188; J3KN86; P23396; Q498B5; Q8NI95" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.106" "1.156" "1.164" "1.150" "1.126" "1.391" "1.381" "1.338" "1.214" "1644.0" "1818.8" "1900.6" "1913.8" "1890.8" "1851.9" "2287.1" "2270.3" "2200.0" "1995.9" "" "" "" "" "" "" "" "" "" "" "1540.5" "1505.0" "1764.5" "1479.4" "1611.7" "1769.4" "2089.8" "2015.8" "2200.0" "1921.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5455074280924099638" "False" "High" "IsMasterProtein" "Q15554" "Telomeric repeat-binding factor 2 OS=Homo sapiens OX=9606 GN=TERF2 PE=1 SV=3" "0.000" "False" "33.078" "23" "10" "10" "10" "542" "59.6" "9.35" "33.55" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf08558, Pf16772" "7014" "ENSG00000132604" "TERF2" "hsa:7014; Q15554" "Hematopoietic stem cell gene regulation by GABP alpha/beta complex; DNA repair pathways, full network; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "Meiotic synapsis; Telomere Extension By Telomerase; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Removal of the Flap Intermediate from the C-strand" "17" "0" "0.991" "1.018" "1.169" "1.036" "1.026" "1.081" "1.020" "1.023" "1.036" "828.5" "821.2" "843.3" "968.1" "858.6" "850.3" "895.3" "845.0" "847.7" "858.7" "" "" "" "" "" "" "" "" "" "" "776.3" "679.6" "782.9" "748.4" "731.9" "812.4" "818.1" "750.2" "847.7" "826.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8737911317243548471" "False" "High" "IsMasterProtein" "Q15631" "Translin OS=Homo sapiens OX=9606 GN=TSN PE=1 SV=1" "0.000" "False" "33.073" "30" "8" "15" "8" "228" "26.2" "6.44" "47.08" "8" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01997" "7247" "ENSG00000211460" "TSN" "B7Z3X8; hsa:7247; Q15631; Q5U0K7" "" "Small interfering RNA (siRNA) biogenesis" "1" "0" "0.922" "0.987" "0.931" "0.915" "0.927" "0.883" "0.958" "0.947" "0.919" "2449.3" "2257.1" "2417.5" "2280.4" "2242.3" "2269.3" "2162.6" "2346.0" "2320.3" "2250.5" "" "" "" "" "" "" "" "" "" "" "2295.0" "1867.7" "2244.4" "1762.9" "1911.3" "2168.1" "1976.1" "2083.0" "2320.3" "2166.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8985233522455606046" "False" "High" "IsMasterProtein" "P61758" "Prefoldin subunit 3 OS=Homo sapiens OX=9606 GN=VBP1 PE=1 SV=4" "0.000" "False" "33.073" "46" "11" "23" "11" "197" "22.6" "7.11" "61.17" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02996" "7411" "ENSG00000155959" "VBP1" "B2R8L5; B4DWR3; F5H2A7; hsa:7411; O55228; P61758; Q15765; Q5JT81; Q86X96" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "1.009" "0.936" "0.990" "0.968" "1.047" "0.993" "0.990" "0.993" "1.036" "1721.9" "1737.4" "1611.4" "1704.6" "1667.1" "1802.4" "1710.2" "1704.3" "1710.4" "1784.0" "" "" "" "" "" "" "" "" "" "" "1613.4" "1437.6" "1496.0" "1317.7" "1421.0" "1722.0" "1562.6" "1513.2" "1710.4" "1717.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1679721907195940966" "False" "High" "IsMasterProtein" "P50502" "Hsc70-interacting protein OS=Homo sapiens OX=9606 GN=ST13 PE=1 SV=2" "0.000" "False" "33.063" "25" "9" "24" "9" "369" "41.3" "5.27" "66.68" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf17830, Pf18253" "6767" "ENSG00000100380" "ST13" "hsa:6767; O14999; P50502; Q2TU77" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "1.011" "1.002" "0.894" "0.981" "0.978" "0.954" "1.033" "0.939" "0.944" "2805.6" "2836.5" "2812.0" "2509.5" "2752.2" "2744.1" "2677.9" "2898.4" "2633.9" "2648.3" "" "" "" "" "" "" "" "" "" "" "2628.9" "2347.2" "2610.6" "1940.0" "2345.9" "2621.7" "2446.9" "2573.5" "2633.9" "2549.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-319216844392798796" "False" "High" "IsMasterProtein" "Q9Y4R8" "Telomere length regulation protein TEL2 homolog OS=Homo sapiens OX=9606 GN=TELO2 PE=1 SV=2" "0.000" "False" "33.062" "14" "13" "16" "13" "837" "91.7" "5.76" "45.92" "13" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10193" "9894" "ENSG00000100726" "TELO2" "D3DU73; hsa:9894; O75168; Q7LDV4; Q9BR21; Q9Y4R8" "Fragile X syndrome; Pleural mesothelioma" "" "2" "0" "1.000" "1.070" "1.076" "1.048" "1.064" "0.997" "0.952" "0.979" "1.035" "1308.5" "1308.5" "1400.2" "1408.1" "1371.6" "1392.7" "1304.7" "1245.7" "1281.0" "1354.0" "" "" "" "" "" "" "" "" "" "" "1226.1" "1082.8" "1299.9" "1088.5" "1169.1" "1330.6" "1192.1" "1106.0" "1281.0" "1303.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4567106574901643860" "False" "High" "IsMasterProtein" "O60826" "Coiled-coil domain-containing protein 22 OS=Homo sapiens OX=9606 GN=CCDC22 PE=1 SV=1" "0.000" "False" "33.028" "22" "11" "11" "11" "627" "70.7" "6.74" "34.93" "11" "transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle" "other molecular function" "Pf05667, Pf21674" "28952" "ENSG00000101997" "CCDC22" "A8K7G1; hsa:28952; O60826" "" "Neddylation" "1" "0" "0.966" "0.927" "1.060" "1.023" "1.001" "1.029" "1.002" "0.934" "0.986" "431.2" "416.6" "399.6" "457.0" "441.1" "431.4" "443.5" "431.9" "402.7" "425.1" "" "" "" "" "" "" "" "" "" "" "404.0" "344.8" "371.0" "353.3" "376.0" "412.2" "405.2" "383.5" "402.7" "409.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8166763961734876416" "False" "High" "IsMasterProtein" "P54727" "UV excision repair protein RAD23 homolog B OS=Homo sapiens OX=9606 GN=RAD23B PE=1 SV=1" "0.000" "False" "33.020" "22" "9" "19" "7" "409" "43.1" "4.84" "54.63" "9" "protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00627, Pf09280" "5887" "ENSG00000119318" "RAD23B" "B3KWK8; G5E9P0; hsa:5887; P54727; Q7Z5K8; Q8WUB0" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; HDAC6 interactions in the central nervous system" "Josephin domain DUBs; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "8" "1" "1.129" "0.990" "1.024" "1.027" "1.008" "1.035" "1.066" "0.970" "1.005" "2386.1" "2694.3" "2361.3" "2443.6" "2450.6" "2405.1" "2469.7" "2543.6" "2314.1" "2398.9" "" "" "" "" "" "" "" "" "" "" "2235.8" "2229.5" "2192.2" "1889.0" "2088.8" "2297.9" "2256.6" "2258.5" "2314.1" "2309.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5779519367271372583" "False" "High" "IsMasterProtein" "Q15645" "Pachytene checkpoint protein 2 homolog OS=Homo sapiens OX=9606 GN=TRIP13 PE=1 SV=2" "0.000" "False" "33.017" "27" "11" "12" "11" "432" "48.5" "6.09" "40.54" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00004" "9319" "ENSG00000071539" "TRIP13" "C9K0T3; D3DTC0; hsa:9319; O15324; Q15645" "Male infertility" "" "1" "0" "0.989" "1.029" "1.098" "1.105" "1.016" "0.937" "0.990" "0.995" "1.011" "630.6" "623.6" "648.9" "692.3" "697.0" "640.5" "591.2" "624.6" "627.3" "637.8" "" "" "" "" "" "" "" "" "" "" "590.9" "516.0" "602.4" "535.2" "594.1" "611.9" "540.2" "554.6" "627.3" "614.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "677526654360538548" "False" "High" "IsMasterProtein" "Q99733" "Nucleosome assembly protein 1-like 4 OS=Homo sapiens OX=9606 GN=NAP1L4 PE=1 SV=1" "0.000" "False" "32.970" "28" "10" "22" "9" "375" "42.8" "4.69" "54.18" "10" "cell organization and biogenesis" "nucleus;other cell component" "other molecular function" "Pf00956" "4676" "ENSG00000205531; ENSG00000273562" "NAP1L4" "B2R6J4; F5HFY4; hsa:4676; Q99733" "" "" "0" "1" "1.060" "0.997" "1.039" "0.982" "0.975" "0.920" "0.976" "0.961" "1.001" "2836.6" "3006.5" "2829.4" "2946.3" "2785.8" "2765.9" "2610.9" "2767.4" "2725.5" "2839.4" "" "" "" "" "" "" "" "" "" "" "2657.9" "2487.8" "2626.7" "2277.6" "2374.5" "2642.6" "2385.6" "2457.2" "2725.5" "2733.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4706681870966743539" "False" "High" "IsMasterProtein" "Q9BWU0" "Kanadaptin OS=Homo sapiens OX=9606 GN=SLC4A1AP PE=1 SV=2" "0.000" "False" "32.959" "15" "10" "13" "10" "742" "82.8" "5.10" "46.90" "10" "" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf00035, Pf00498" "22950" "ENSG00000163798" "SLC4A1AP" "A0A087X0M4; A6NJ39; hsa:22950; Q4KMT1; Q4KMX0; Q7Z5Q9; Q9BWU0; Q9NVN2" "" "" "0" "0" "0.981" "1.024" "0.948" "0.998" "1.033" "0.991" "0.876" "0.991" "1.026" "1131.9" "1110.0" "1158.8" "1072.8" "1129.4" "1169.2" "1121.9" "991.6" "1122.2" "1160.9" "" "" "" "" "" "" "" "" "" "" "1060.6" "918.6" "1075.8" "829.4" "962.7" "1117.0" "1025.1" "880.5" "1122.2" "1117.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3851327045355939363" "False" "High" "IsMasterProtein" "P16401" "Histone H1.5 OS=Homo sapiens OX=9606 GN=H1-5 PE=1 SV=3" "0.000" "False" "32.904" "36" "10" "17" "7" "226" "22.6" "10.92" "61.23" "10" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3009" "ENSG00000184357" "H1-5" "hsa:3009; P16401; Q14529; Q3MJ42" "" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "2" "0" "1.061" "1.050" "0.928" "1.009" "1.026" "0.967" "1.030" "0.986" "0.966" "1044.8" "1109.0" "1097.0" "969.2" "1054.6" "1072.4" "1010.1" "1076.6" "1030.4" "1009.5" "" "" "" "" "" "" "" "" "" "" "979.0" "917.7" "1018.5" "749.3" "898.9" "1024.6" "923.0" "955.9" "1030.4" "972.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2594801350968766228" "False" "High" "IsMasterProtein" "Q99986" "Serine/threonine-protein kinase VRK1 OS=Homo sapiens OX=9606 GN=VRK1 PE=1 SV=1" "0.000" "False" "32.873" "27" "10" "15" "10" "396" "45.4" "8.91" "51.68" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus" "kinase activity;other molecular function" "Pf00069" "7443" "ENSG00000100749" "VRK1" "hsa:7443; Q3SYL2; Q99986" "" "Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation" "2" "0" "0.946" "1.042" "0.959" "1.021" "1.077" "1.005" "1.062" "1.062" "1.045" "2028.8" "1918.6" "2114.8" "1945.8" "2072.4" "2184.5" "2039.6" "2155.4" "2153.7" "2119.7" "" "" "" "" "" "" "" "" "" "" "1901.0" "1587.6" "1963.3" "1504.2" "1766.5" "2087.1" "1863.6" "1913.8" "2153.7" "2041.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4921032794514216116" "False" "High" "IsMasterProtein" "Q8WXX5" "DnaJ homolog subfamily C member 9 OS=Homo sapiens OX=9606 GN=DNAJC9 PE=1 SV=1" "0.000" "False" "32.856" "43" "10" "13" "10" "260" "29.9" "5.73" "43.97" "10" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00226" "23234" "ENSG00000213551" "DNAJC9" "B2RMW6; hsa:23234; Q8WXX5" "" "" "0" "0" "1.053" "0.956" "0.843" "0.943" "0.935" "0.966" "0.933" "0.918" "0.959" "1494.4" "1573.6" "1428.0" "1260.0" "1409.2" "1398.0" "1443.1" "1393.9" "1372.6" "1433.6" "" "" "" "" "" "" "" "" "" "" "1400.2" "1302.1" "1325.7" "974.0" "1201.2" "1335.6" "1318.6" "1237.6" "1372.6" "1380.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3240734639385883819" "False" "High" "IsMasterProtein" "P53004" "Biliverdin reductase A OS=Homo sapiens OX=9606 GN=BLVRA PE=1 SV=2" "0.000" "False" "32.827" "35" "10" "14" "10" "296" "33.4" "6.44" "52.67" "10" "other metabolic processes" "cytosol" "other molecular function" "Pf01408, Pf09166" "644" "ENSG00000106605" "BLVRA" "A8K747; hsa:644; O95019; P53004; Q86UX0; Q96QL4; Q9BRW8" "IL-10 anti-inflammatory signaling pathway" "Cytoprotection by HMOX1; Heme degradation" "3" "0" "0.924" "1.016" "0.959" "0.981" "0.986" "0.959" "0.981" "0.953" "0.954" "1915.7" "1770.6" "1946.0" "1836.3" "1878.8" "1889.1" "1838.0" "1880.2" "1826.0" "1827.3" "" "" "" "" "" "" "" "" "" "" "1795.0" "1465.2" "1806.7" "1419.5" "1601.4" "1804.9" "1679.4" "1669.4" "1826.0" "1759.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4480157126328656163" "False" "High" "IsMasterProtein" "O75937" "DnaJ homolog subfamily C member 8 OS=Homo sapiens OX=9606 GN=DNAJC8 PE=1 SV=2" "0.000" "False" "32.826" "39" "11" "21" "11" "253" "29.8" "9.06" "70.56" "11" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf00226" "22826" "ENSG00000126698" "DNAJC8" "B4DUU4; D3DPM0; hsa:22826; O75937; Q6IBA4; Q8N4Z5; Q9P051; Q9P067" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.031" "1.010" "0.970" "1.017" "1.020" "1.002" "1.064" "1.004" "1.019" "3386.0" "3490.6" "3420.0" "3283.1" "3442.8" "3454.6" "3393.5" "3601.3" "3400.0" "3451.2" "" "" "" "" "" "" "" "" "" "" "3172.7" "2888.4" "3175.0" "2538.0" "2934.5" "3300.6" "3100.7" "3197.6" "3400.0" "3323.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7175242905837588229" "False" "High" "IsMasterProtein" "O95747" "Serine/threonine-protein kinase OSR1 OS=Homo sapiens OX=9606 GN=OXSR1 PE=1 SV=1" "0.000" "False" "32.825" "19" "9" "15" "9" "527" "58.0" "6.43" "44.93" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12202" "9943" "ENSG00000172939" "OXSR1" "hsa:9943; O95747; Q3LR53; Q7Z501; Q9UPQ1" "" "" "0" "0" "0.983" "1.013" "0.981" "1.022" "1.009" "1.023" "0.990" "1.012" "0.995" "1105.6" "1087.2" "1120.0" "1084.5" "1130.5" "1115.4" "1130.5" "1094.6" "1119.0" "1100.5" "" "" "" "" "" "" "" "" "" "" "1036.0" "899.7" "1039.8" "838.4" "963.6" "1065.7" "1033.0" "971.9" "1119.0" "1059.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8802670806529502835" "False" "High" "IsMasterProtein" "Q6NYC8" "Phostensin OS=Homo sapiens OX=9606 GN=PPP1R18 PE=1 SV=1" "0.000" "False" "32.791" "18" "10" "11" "10" "613" "67.9" "5.40" "41.10" "10" "" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf13914, Pf13916" "170954" "ENSG00000146112; ENSG00000206485; ENSG00000225060; ENSG00000229998; ENSG00000230341; ENSG00000234000" "PPP1R18" "A2AB01; A2AIB8; A4UBI6; A6NCB7; A8MSS7; B7ZCV7; hsa:170954; Q68CK8; Q6NYC8; Q6ZTV1; Q6ZUJ6; Q8NDQ4; Q8TF52; Q9BRL9" "TYROBP causal network in microglia" "" "1" "0" "1.065" "0.985" "1.167" "1.184" "1.246" "1.221" "1.348" "1.247" "1.162" "741.6" "789.9" "730.6" "865.5" "878.1" "923.9" "905.5" "999.8" "925.0" "861.8" "" "" "" "" "" "" "" "" "" "" "694.9" "653.7" "678.3" "669.1" "748.5" "882.7" "827.3" "887.7" "925.0" "829.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9009655612245832545" "False" "High" "IsMasterProtein" "Q9Y4G6" "Talin-2 OS=Homo sapiens OX=9606 GN=TLN2 PE=1 SV=4" "0.000" "False" "32.783" "4" "11" "16" "1" "2542" "271.4" "5.57" "57.50" "11" "cell adhesion;cell organization and biogenesis" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00373, Pf01608, Pf08913, Pf09141, Pf09379, Pf16511, Pf21692" "83660" "ENSG00000171914" "TLN2" "A6NLB8; hsa:83660; Q9Y4G6" "Focal adhesion" "" "1" "1" "0.953" "0.994" "0.912" "1.027" "1.040" "1.070" "0.925" "0.977" "0.998" "468.2" "446.1" "465.5" "427.1" "480.9" "487.0" "501.0" "432.9" "457.3" "467.3" "" "" "" "" "" "" "" "" "" "" "438.7" "369.1" "432.2" "330.1" "409.9" "465.2" "457.8" "384.4" "457.3" "449.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4784462983212685670" "False" "High" "IsMasterProtein" "Q96KP4" "Cytosolic non-specific dipeptidase OS=Homo sapiens OX=9606 GN=CNDP2 PE=1 SV=2" "0.000" "False" "32.742" "24" "10" "17" "10" "475" "52.8" "5.97" "55.41" "10" "protein metabolism" "cytosol;nucleus" "other molecular function" "Pf01546, Pf07687" "55748" "ENSG00000133313" "CNDP2" "B3KUG4; hsa:55748; Q8WY59; Q96KP4; Q9BQ94; Q9NVB4; V9HWE5" "" "Glutathione synthesis and recycling; Paracetamol ADME" "2" "0" "0.932" "0.936" "0.951" "0.899" "1.012" "0.887" "0.942" "0.889" "0.940" "2534.1" "2360.6" "2372.6" "2409.8" "2277.6" "2564.8" "2247.7" "2387.8" "2253.8" "2381.5" "" "" "" "" "" "" "" "" "" "" "2374.4" "1953.4" "2202.7" "1862.9" "1941.4" "2450.4" "2053.8" "2120.1" "2253.8" "2293.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4231086194268643311" "False" "High" "IsMasterProtein" "Q8N6R0" "eEF1A lysine and N-terminal methyltransferase OS=Homo sapiens OX=9606 GN=METTL13 PE=1 SV=1" "0.000" "False" "32.732" "15" "11" "15" "11" "699" "78.7" "6.73" "39.90" "11" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01564, Pf13847" "51603" "ENSG00000010165" "METTL13" "A6NFK0; A8K6S5; hsa:51603; O94940; Q53EZ6; Q5TGP9; Q5TGQ0; Q8N2P8; Q8N6R0; Q96J11; Q96SQ0; Q9Y2Z1; Q9Y3M6" "" "" "0" "0" "1.012" "1.029" "1.063" "1.043" "0.978" "0.966" "0.958" "0.962" "0.983" "845.1" "854.9" "869.7" "898.5" "881.1" "826.2" "816.3" "809.7" "812.7" "830.3" "" "" "" "" "" "" "" "" "" "" "791.8" "707.4" "807.4" "694.6" "751.0" "789.3" "745.9" "718.9" "812.7" "799.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4128416838288873001" "False" "High" "IsMasterProtein" "P11177" "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=PDHB PE=1 SV=3" "0.000" "False" "32.706" "28" "9" "16" "9" "359" "39.2" "6.65" "49.06" "9" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf02779, Pf02780" "5162" "ENSG00000168291" "PDHB" "B2R7L0; B4DDD7; hsa:5162; P11177; Q6FH45; Q9BQ27; Q9UFK3" "Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Orexin receptor pathway" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "8" "0" "1.071" "1.130" "1.014" "1.101" "1.131" "1.054" "1.117" "1.106" "1.051" "1132.3" "1212.3" "1279.9" "1148.3" "1247.0" "1280.3" "1194.0" "1264.7" "1252.6" "1190.3" "" "" "" "" "" "" "" "" "" "" "1061.0" "1003.2" "1188.3" "887.7" "1062.9" "1223.2" "1091.0" "1122.9" "1252.6" "1146.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8647128743561798150" "False" "High" "IsMasterProtein" "P78417" "Glutathione S-transferase omega-1 OS=Homo sapiens OX=9606 GN=GSTO1 PE=1 SV=2" "0.000" "False" "32.699" "36" "9" "20" "9" "241" "27.5" "6.60" "65.20" "9" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13409, Pf14497" "9446" "ENSG00000148834" "GSTO1" "D3DRA3; F5H7H0; hsa:9446; P78417; Q5TA03; Q7Z3T2" "Myometrial relaxation and contraction pathways; Arsenic metabolism and reactive oxygen species generation; Metapathway biotransformation Phase I and II" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Glutathione conjugation; Vitamin C (ascorbate) metabolism; Methylation" "7" "0" "0.938" "0.962" "0.911" "0.932" "1.270" "1.276" "1.024" "1.287" "1.063" "1826.2" "1712.7" "1757.6" "1663.4" "1701.5" "2320.0" "2329.4" "1870.4" "2350.0" "1941.6" "" "" "" "" "" "" "" "" "" "" "1711.2" "1417.3" "1631.7" "1285.9" "1450.4" "2216.5" "2128.4" "1660.7" "2350.0" "1869.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2410269861090895387" "False" "High" "IsMasterProtein" "Q9NZT2" "Opioid growth factor receptor OS=Homo sapiens OX=9606 GN=OGFR PE=1 SV=3" "0.000" "False" "32.679" "18" "10" "10" "10" "677" "73.3" "4.84" "38.57" "10" "other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf04664, Pf04680" "11054" "ENSG00000060491" "OGFR" "hsa:11054; O96029; Q4VXW5; Q96CM2; Q9BQW1; Q9H4H0; Q9H7J5; Q9NZT2; Q9NZT3; Q9NZT4" "" "" "0" "0" "0.975" "0.956" "1.001" "0.991" "1.009" "0.901" "0.909" "0.896" "0.970" "1405.5" "1370.7" "1344.0" "1406.2" "1393.5" "1418.3" "1266.5" "1277.8" "1258.8" "1363.8" "" "" "" "" "" "" "" "" "" "" "1316.9" "1134.2" "1247.7" "1087.1" "1187.8" "1355.0" "1157.2" "1134.5" "1258.8" "1313.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4191413839330820481" "False" "High" "IsMasterProtein" "O14979" "Heterogeneous nuclear ribonucleoprotein D-like OS=Homo sapiens OX=9606 GN=HNRNPDL PE=1 SV=3" "0.000" "False" "32.662" "25" "10" "24" "8" "420" "46.4" "9.57" "66.82" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf00076" "9987" "ENSG00000152795" "HNRNPDL" "hsa:9987; O14979; Q6SPF2; Q7KZ74; Q7KZ75; Q96IM0; Q96S43" "" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "1" "0" "1.143" "1.049" "1.084" "0.971" "0.936" "0.864" "1.006" "0.973" "0.970" "2230.9" "2549.3" "2340.4" "2417.5" "2165.4" "2087.9" "1926.7" "2243.8" "2170.9" "2164.5" "" "" "" "" "" "" "" "" "" "" "2090.3" "2109.5" "2172.8" "1868.9" "1845.7" "1994.8" "1760.5" "1992.2" "2170.9" "2084.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7804593392060362224" "False" "High" "IsMasterProtein" "P14324" "Farnesyl pyrophosphate synthase OS=Homo sapiens OX=9606 GN=FDPS PE=1 SV=4" "0.000" "False" "32.642" "18" "8" "16" "8" "419" "48.2" "6.15" "54.25" "8" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00348" "2224" "ENSG00000160752" "FDPS" "D3DV91; E9PCI9; hsa:2224; P14324; Q96G29" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "9" "0" "0.888" "0.963" "0.881" "0.894" "0.980" "0.900" "0.941" "0.993" "0.978" "2057.2" "1826.0" "1980.2" "1813.0" "1839.9" "2016.5" "1850.5" "1935.2" "2042.5" "2012.4" "" "" "" "" "" "" "" "" "" "" "1927.6" "1511.0" "1838.4" "1401.6" "1568.2" "1926.6" "1690.8" "1718.3" "2042.5" "1937.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3137976061761612537" "False" "High" "IsMasterProtein" "Q16512" "Serine/threonine-protein kinase N1 OS=Homo sapiens OX=9606 GN=PKN1 PE=1 SV=2" "0.000" "False" "32.628" "12" "13" "16" "11" "942" "103.9" "6.37" "43.21" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433, Pf02185" "5585" "ENSG00000123143" "PKN1" "A8K7W5; B2R9R4; B3KVN3; hsa:5585; Q15143; Q16512; Q504U4; Q8IUV5; Q9UD44" "Apoptosis-related network due to altered Notch3 in ovarian cancer; PI3K-Akt signaling pathway; IL-18 signaling pathway; G13 signaling pathway" "RHOA GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; RHOC GTPase cycle" "10" "2" "0.996" "1.006" "0.977" "0.977" "1.002" "0.947" "0.949" "0.966" "1.004" "2506.5" "2496.5" "2520.4" "2448.1" "2449.3" "2512.6" "2374.3" "2379.2" "2420.2" "2516.8" "" "" "" "" "" "" "" "" "" "" "2348.6" "2065.8" "2339.8" "1892.5" "2087.7" "2400.5" "2169.5" "2112.5" "2420.2" "2423.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6910081975799465505" "False" "High" "IsMasterProtein" "O15042" "U2 snRNP-associated SURP motif-containing protein OS=Homo sapiens OX=9606 GN=U2SURP PE=1 SV=2" "0.000" "False" "32.625" "11" "12" "16" "12" "1029" "118.2" "8.47" "45.00" "12" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00076, Pf01805, Pf04818, Pf08312" "23350" "ENSG00000163714" "U2SURP" "A0PJ60; hsa:23350; O15042; Q0D2M1; Q2NKQ7; Q9BR70" "" "mRNA Splicing - Major Pathway" "1" "0" "1.037" "1.071" "1.180" "1.162" "1.112" "1.660" "1.584" "1.668" "1.305" "1770.9" "1836.1" "1896.2" "2089.2" "2057.0" "1968.9" "2939.2" "2805.4" "2954.0" "2310.4" "" "" "" "" "" "" "" "" "" "" "1659.3" "1519.4" "1760.4" "1615.0" "1753.3" "1881.1" "2685.7" "2490.9" "2954.0" "2224.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4097484419734302186" "False" "High" "IsMasterProtein" "Q9UBL3" "Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Homo sapiens OX=9606 GN=ASH2L PE=1 SV=1" "0.000" "False" "32.620" "17" "11" "13" "11" "628" "68.7" "5.69" "41.92" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00622, Pf21198, Pf21257" "9070" "ENSG00000129691" "ASH2L" "A8K7C3; D3DSW9; hsa:9070; O60659; O60660; Q96B62; Q9UBL3" "Kleefstra syndrome" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Formation of WDR5-containing histone-modifying complexes; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "7" "0" "0.980" "1.023" "0.953" "1.001" "0.980" "0.988" "1.007" "1.007" "0.977" "2957.9" "2898.4" "3026.9" "2819.6" "2962.2" "2899.4" "2921.6" "2978.6" "2978.5" "2888.6" "" "" "" "" "" "" "" "" "" "" "2771.6" "2398.4" "2810.1" "2179.7" "2524.9" "2770.1" "2669.6" "2644.7" "2978.5" "2781.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6289921617317730415" "False" "High" "IsMasterProtein" "Q9BWF3" "RNA-binding protein 4 OS=Homo sapiens OX=9606 GN=RBM4 PE=1 SV=1" "0.000" "False" "32.613" "32" "12" "18" "1" "364" "40.3" "7.08" "50.23" "12" "cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00098" "5936" "ENSG00000173933" "RBM4" "B3KUN0; B4E1U0; E7EQS3; hsa:5936; O02916; Q4VC48; Q6P1P2; Q8WU85; Q9BWF3" "" "Circadian Clock" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4962513167934133051" "False" "High" "IsMasterProtein" "P49643" "DNA primase large subunit OS=Homo sapiens OX=9606 GN=PRIM2 PE=1 SV=2" "0.000" "False" "32.605" "21" "10" "10" "10" "509" "58.8" "7.91" "33.56" "10" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf04104" "5558" "ENSG00000146143" "PRIM2" "hsa:5558; P49643; Q53FJ8; Q6P1Q7; Q8WVL2; Q9H413" "Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "Defective pyroptosis; Polymerase switching on the C-strand of the telomere; Polymerase switching; Activation of the pre-replicative complex; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Telomere C-strand synthesis initiation; DNA replication initiation; Removal of the Flap Intermediate" "12" "0" "0.939" "0.997" "0.906" "0.960" "1.020" "0.948" "0.924" "1.053" "0.987" "1200.9" "1127.6" "1197.5" "1088.3" "1152.5" "1225.0" "1138.5" "1109.7" "1264.1" "1185.4" "" "" "" "" "" "" "" "" "" "" "1125.2" "933.1" "1111.7" "841.3" "982.3" "1170.3" "1040.3" "985.3" "1264.1" "1141.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1756895692335459560" "False" "High" "IsMasterProtein" "O95865" "Putative hydrolase DDAH2 OS=Homo sapiens OX=9606 GN=DDAH2 PE=1 SV=1" "0.000" "False" "32.558" "46" "11" "12" "11" "285" "29.6" "6.01" "33.30" "11" "other metabolic processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "" "23564" "ENSG00000206395; ENSG00000213722; ENSG00000225635; ENSG00000226634; ENSG00000227317; ENSG00000228128; ENSG00000233076" "DDAH2" "A2BEZ7; hsa:23564; O95865" "Nitric oxide metabolism in cystic fibrosis" "" "1" "0" "0.995" "1.006" "1.065" "0.979" "1.003" "0.981" "1.036" "0.959" "0.969" "977.4" "972.3" "983.3" "1040.5" "956.5" "980.3" "958.5" "1012.2" "937.4" "946.8" "" "" "" "" "" "" "" "" "" "" "915.8" "804.6" "912.9" "804.4" "815.3" "936.6" "875.8" "898.7" "937.4" "911.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6258947584785222358" "False" "High" "IsMasterProtein" "P62906" "Large ribosomal subunit protein uL1 OS=Homo sapiens OX=9606 GN=RPL10A PE=1 SV=2" "0.000" "False" "32.531" "33" "7" "23" "7" "217" "24.8" "9.94" "67.92" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00687" "4736" "ENSG00000198755" "RPL10A" "B2R801; hsa:4736; P52859; P53025; P62906; Q5TZT6; Q8J013" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.042" "1.162" "1.309" "1.367" "1.446" "1.360" "1.406" "1.380" "1.286" "1987.7" "2071.2" "2309.6" "2602.7" "2717.8" "2873.5" "2703.0" "2795.5" "2743.5" "2556.8" "" "" "" "" "" "" "" "" "" "" "1862.5" "1713.9" "2144.1" "2012.0" "2316.5" "2745.3" "2469.8" "2482.1" "2743.5" "2461.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4892989875718200247" "False" "High" "IsMasterProtein" "Q9UL46" "Proteasome activator complex subunit 2 OS=Homo sapiens OX=9606 GN=PSME2 PE=1 SV=4" "0.000" "False" "32.519" "39" "11" "22" "11" "239" "27.4" "5.73" "49.52" "11" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02251, Pf02252" "5721" "ENSG00000100911; ENSG00000284889" "PSME2" "hsa:5721; Q15129; Q9UL46" "Proteasome degradation" "Ub-specific processing proteases; UCH proteinases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Orc1 removal from chromatin; Regulation of RUNX2 expression and activity; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Interleukin-1 signaling; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of expression of SLITs and ROBOs; KEAP1-NFE2L2 pathway; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Hedgehog 'on' state; Regulation of RAS by GAPs; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of PTEN stability and activity; Somitogenesis; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Regulation of RUNX3 expression and activity" "61" "0" "0.821" "0.905" "0.916" "0.812" "0.966" "0.932" "0.935" "0.946" "0.913" "2483.8" "2040.4" "2248.1" "2274.0" "2017.0" "2399.9" "2316.0" "2321.3" "2348.9" "2267.8" "" "" "" "" "" "" "" "" "" "" "2327.3" "1688.4" "2087.1" "1757.9" "1719.2" "2292.9" "2116.2" "2061.1" "2348.9" "2183.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-662139928789152118" "False" "High" "IsMasterProtein" "Q8WYJ6" "Septin-1 OS=Homo sapiens OX=9606 GN=SEPTIN1 PE=1 SV=3" "0.000" "False" "32.505" "34" "11" "15" "11" "372" "42.4" "5.80" "50.31" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "1731" "ENSG00000180096" "SEPTIN1" "B4DVE6; hsa:1731; Q658T1; Q8NEZ1; Q8WYJ6; Q96EL4; Q9H285" "" "" "0" "0" "1.037" "1.050" "1.070" "1.067" "1.005" "1.012" "0.985" "0.965" "1.038" "967.1" "1002.5" "1014.9" "1034.7" "1031.5" "971.7" "978.7" "952.1" "933.1" "1003.5" "" "" "" "" "" "" "" "" "" "" "906.1" "829.6" "942.2" "799.9" "879.3" "928.4" "894.3" "845.4" "933.1" "966.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5459643991948160099" "False" "High" "IsMasterProtein" "Q9NWH9" "SAFB-like transcription modulator OS=Homo sapiens OX=9606 GN=SLTM PE=1 SV=2" "0.000" "False" "32.503" "12" "12" "17" "12" "1034" "117.1" "7.87" "40.59" "12" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf02037" "79811" "ENSG00000137776" "SLTM" "A8K5V8; B2RTX3; hsa:79811; Q2VPK7; Q52MB3; Q658J7; Q6ZNF2; Q86TK6; Q9H7C3; Q9H8U9; Q9NWH9" "" "" "0" "0" "1.014" "0.991" "1.014" "1.001" "1.023" "1.040" "1.063" "1.094" "1.000" "1258.8" "1276.8" "1247.8" "1276.7" "1260.2" "1287.3" "1308.9" "1337.7" "1376.8" "1258.5" "" "" "" "" "" "" "" "" "" "" "1179.5" "1056.6" "1158.4" "987.0" "1074.2" "1229.9" "1196.0" "1187.8" "1376.8" "1211.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2043411241930693309" "False" "High" "IsMasterProtein" "Q96JM3" "Chromosome alignment-maintaining phosphoprotein 1 OS=Homo sapiens OX=9606 GN=CHAMP1 PE=1 SV=2" "0.000" "False" "32.499" "16" "11" "12" "11" "812" "89.0" "8.44" "32.43" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "" "283489" "ENSG00000198824" "CHAMP1" "B3KU06; hsa:283489; Q6P181; Q8NC88; Q96JM3; Q9BST0" "" "" "0" "0" "1.010" "1.001" "1.029" "1.056" "1.027" "1.093" "1.096" "1.046" "1.103" "1267.5" "1279.6" "1269.1" "1304.3" "1338.8" "1301.4" "1384.9" "1388.8" "1325.9" "1398.0" "" "" "" "" "" "" "" "" "" "" "1187.6" "1058.9" "1178.2" "1008.3" "1141.2" "1243.4" "1265.4" "1233.1" "1325.9" "1346.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1141032543915842811" "False" "High" "IsMasterProtein" "Q13011" "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial OS=Homo sapiens OX=9606 GN=ECH1 PE=1 SV=2" "0.000" "False" "32.480" "30" "9" "15" "9" "328" "35.8" "8.00" "47.89" "9" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00378" "1891" "ENSG00000104823; ENSG00000282853" "ECH1" "A8K745; hsa:1891; Q13011; Q8WVX0; Q96EZ9" "Fatty acid biosynthesis; IL-18 signaling pathway" "Peroxisomal protein import; Mitochondrial protein degradation" "4" "0" "0.973" "0.986" "0.938" "0.933" "0.990" "0.933" "0.943" "0.992" "0.946" "2579.4" "2509.5" "2543.4" "2419.9" "2406.5" "2552.6" "2406.6" "2433.2" "2558.4" "2439.4" "" "" "" "" "" "" "" "" "" "" "2416.9" "2076.6" "2361.2" "1870.7" "2051.2" "2438.8" "2199.0" "2160.5" "2558.4" "2348.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8827666052570193854" "False" "High" "IsMasterProtein" "Q15056" "Eukaryotic translation initiation factor 4H OS=Homo sapiens OX=9606 GN=EIF4H PE=1 SV=5" "0.000" "False" "32.466" "42" "10" "18" "10" "248" "27.4" "7.23" "52.98" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00076" "7458" "ENSG00000106682" "EIF4H" "A8K3R1; D3DXF6; D3DXF8; hsa:7458; Q15056" "Translation factors; 7q11.23 copy number variation syndrome" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Ribosomal scanning and start codon recognition" "7" "0" "1.161" "0.997" "1.059" "1.003" "0.955" "0.985" "0.926" "0.879" "0.993" "1607.6" "1867.2" "1602.6" "1702.8" "1611.8" "1535.2" "1583.7" "1488.9" "1412.8" "1596.7" "" "" "" "" "" "" "" "" "" "" "1506.3" "1545.1" "1487.8" "1316.3" "1373.8" "1466.7" "1447.1" "1322.0" "1412.8" "1537.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7990537509462567326" "False" "High" "IsMasterProtein" "P16298" "Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PPP3CB PE=1 SV=2" "0.000" "False" "32.410" "20" "10" "15" "5" "524" "59.0" "5.91" "45.88" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00149" "5532" "ENSG00000107758" "PPP3CB" "hsa:5532; P16298; P16299; Q5F2F9; Q8N1F0; Q8N3W4" "Physiological and pathological hypertrophy of the heart; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Amyotrophic lateral sclerosis (ALS); Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; Wnt signaling; Alzheimer's disease; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; DARPP-32 events; ROBO receptors bind AKAP5" "16" "4" "1.022" "1.036" "1.045" "0.930" "1.028" "0.958" "0.961" "0.991" "0.985" "1615.9" "1651.1" "1674.5" "1689.1" "1502.9" "1661.9" "1547.4" "1553.1" "1601.7" "1590.9" "" "" "" "" "" "" "" "" "" "" "1514.1" "1366.3" "1554.6" "1305.7" "1281.1" "1587.8" "1413.9" "1379.0" "1601.7" "1531.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2296645769357171248" "False" "High" "IsMasterProtein" "Q4G0J3" "La-related protein 7 OS=Homo sapiens OX=9606 GN=LARP7 PE=1 SV=1" "0.000" "False" "32.410" "19" "10" "10" "10" "582" "66.9" "9.55" "32.87" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf05383, Pf08777" "51574" "ENSG00000174720" "LARP7" "B2ZHN6; hsa:51574; Q3B7A9; Q4G0J3; Q9P1S7; Q9Y3Z8" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.014" "1.029" "1.026" "1.075" "1.026" "1.115" "1.132" "1.049" "1.054" "1741.1" "1764.9" "1791.3" "1786.9" "1871.9" "1785.9" "1942.2" "1971.0" "1826.5" "1835.7" "" "" "" "" "" "" "" "" "" "" "1631.4" "1460.4" "1663.0" "1381.4" "1595.6" "1706.2" "1774.7" "1750.1" "1826.5" "1767.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4330394968015135701" "False" "High" "IsMasterProtein" "Q9P2R3" "Rabankyrin-5 OS=Homo sapiens OX=9606 GN=ANKFY1 PE=1 SV=2" "0.000" "False" "32.340" "9" "10" "14" "10" "1169" "128.3" "6.10" "37.41" "10" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00023, Pf00651, Pf01363, Pf12796" "51479" "ENSG00000185722" "ANKFY1" "A8KA65; hsa:51479; Q5RKV4; Q9P2R3; Q9ULG5" "" "RHOD GTPase cycle" "1" "0" "1.045" "0.971" "0.989" "0.999" "1.010" "0.950" "0.963" "0.961" "1.005" "1398.5" "1460.9" "1357.4" "1383.5" "1396.8" "1412.2" "1328.7" "1346.3" "1343.6" "1405.8" "" "" "" "" "" "" "" "" "" "" "1310.4" "1208.9" "1260.1" "1069.5" "1190.6" "1349.2" "1214.1" "1195.4" "1343.6" "1353.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1246556582121742605" "False" "High" "IsMasterProtein" "Q9P253" "Vacuolar protein sorting-associated protein 18 homolog OS=Homo sapiens OX=9606 GN=VPS18 PE=1 SV=2" "0.000" "False" "32.336" "11" "10" "13" "10" "973" "110.1" "6.07" "42.65" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf05131" "57617" "ENSG00000104142" "VPS18" "hsa:57617; Q8TCG0; Q96DI3; Q9H268; Q9P253" "Ebola virus infection in host; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "SARS-CoV-2 modulates autophagy" "3" "0" "1.014" "1.018" "1.006" "1.031" "1.047" "0.936" "0.943" "0.969" "1.016" "1079.3" "1093.9" "1099.1" "1085.8" "1113.0" "1129.6" "1009.8" "1017.6" "1045.5" "1097.1" "" "" "" "" "" "" "" "" "" "" "1011.3" "905.2" "1020.4" "839.4" "948.7" "1079.2" "922.7" "903.5" "1045.5" "1056.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2629792950046784631" "False" "High" "IsMasterProtein" "Q12849" "G-rich sequence factor 1 OS=Homo sapiens OX=9606 GN=GRSF1 PE=1 SV=3" "0.000" "False" "32.332" "20" "8" "13" "8" "480" "53.1" "6.19" "44.83" "8" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "2926" "ENSG00000132463" "GRSF1" "B3KPW0; hsa:2926; Q12849; Q4W5S5; Q6ZST3; Q8IWD6; Q8NBD2" "VEGFA-VEGFR2 signaling" "Viral mRNA Translation; Mitochondrial RNA degradation" "3" "0" "1.009" "1.030" "0.986" "1.012" "1.012" "0.958" "1.007" "0.956" "0.986" "874.0" "881.8" "900.4" "861.6" "884.8" "884.5" "837.6" "880.4" "835.4" "861.4" "" "" "" "" "" "" "" "" "" "" "818.9" "729.7" "835.9" "666.1" "754.2" "845.1" "765.4" "781.7" "835.4" "829.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2921825731244054349" "False" "High" "IsMasterProtein" "Q99714" "3-hydroxyacyl-CoA dehydrogenase type-2 OS=Homo sapiens OX=9606 GN=HSD17B10 PE=1 SV=3" "0.000" "False" "32.310" "51" "9" "16" "9" "261" "26.9" "7.78" "64.78" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00106" "3028" "ENSG00000072506" "HSD17B10" "hsa:3028; Q5H927; Q6IBS9; Q8TCV9; Q96HD5; Q99714" "Alzheimer's disease and miRNA effects; Valproic acid pathway; Alzheimer's disease" "Branched-chain amino acid catabolism; Mitochondrial protein degradation; tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion" "8" "0" "1.046" "1.024" "1.036" "1.049" "1.043" "0.979" "0.977" "1.076" "1.017" "1266.3" "1324.9" "1296.7" "1311.6" "1328.3" "1320.6" "1240.1" "1237.3" "1362.0" "1288.0" "" "" "" "" "" "" "" "" "" "" "1186.5" "1096.4" "1203.9" "1013.9" "1132.2" "1261.7" "1133.2" "1098.6" "1362.0" "1240.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6941898924238947203" "False" "High" "IsMasterProtein" "P52565" "Rho GDP-dissociation inhibitor 1 OS=Homo sapiens OX=9606 GN=ARHGDIA PE=1 SV=3" "0.000" "False" "32.298" "28" "7" "18" "7" "204" "23.2" "5.11" "56.34" "7" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf02115" "396" "ENSG00000141522" "ARHGDIA" "A8MXW0; B2R5X1; B4DDD3; B4DUV9; hsa:396; P52565; Q6IBM5" "Ciliary landscape; Nephrotic syndrome; Vasopressin-regulated water reabsorption" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOH GTPase cycle; Axonal growth stimulation; Axonal growth inhibition (RHOA activation)" "12" "0" "1.117" "1.013" "0.979" "0.994" "0.966" "0.926" "1.002" "1.124" "1.020" "2252.8" "2516.2" "2281.6" "2206.4" "2239.8" "2176.7" "2086.4" "2257.9" "2531.7" "2297.0" "" "" "" "" "" "" "" "" "" "" "2110.9" "2082.1" "2118.2" "1705.6" "1909.1" "2079.6" "1906.4" "2004.8" "2531.7" "2211.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4573654140983497752" "False" "High" "IsMasterProtein" "P12004" "Proliferating cell nuclear antigen OS=Homo sapiens OX=9606 GN=PCNA PE=1 SV=1" "0.000" "False" "32.290" "41" "10" "33" "10" "261" "28.8" "4.69" "113.94" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00705, Pf02747" "5111" "ENSG00000132646" "PCNA" "B2R897; D3DW02; hsa:5111; P12004" "Cell cycle; Retinoblastoma gene in cancer; Primary focal segmental glomerulosclerosis (FSGS); Oxidative damage response; EGF/EGFR signaling pathway; G1 to S cell cycle control; DNA replication; Hepatitis B infection; Base excision repair; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; 16p11.2 proximal deletion syndrome; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum ; Urotensin-II-mediated signaling pathway; DNA mismatch repair; 10q11.21q11.23 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; NF1 copy number variation syndrome ; Rubinstein-Taybi syndrome 1" "E3 ubiquitin ligases ubiquitinate target proteins; SUMOylation of DNA replication proteins; Termination of translesion DNA synthesis; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; G1/S-Specific Transcription; Recognition of DNA damage by PCNA-containing replication complex; Transcription of E2F targets under negative control by DREAM complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "47" "0" "0.901" "1.004" "0.958" "0.939" "0.906" "0.969" "0.978" "0.940" "0.911" "3020.8" "2722.1" "3032.8" "2892.9" "2836.8" "2736.4" "2928.6" "2953.4" "2840.6" "2750.9" "" "" "" "" "" "" "" "" "" "" "2830.5" "2252.5" "2815.6" "2236.4" "2418.0" "2614.3" "2675.9" "2622.4" "2840.6" "2648.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3353134017530951509" "False" "High" "IsMasterProtein" "Q9Y5K5" "Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Homo sapiens OX=9606 GN=UCHL5 PE=1 SV=3" "0.000" "False" "32.288" "37" "10" "18" "10" "329" "37.6" "5.33" "55.22" "10" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01088, Pf18031" "51377" "ENSG00000116750" "UCHL5" "hsa:51377; Q5LJA6; Q5LJA7; Q8TBS4; Q96BJ9; Q9H1W5; Q9P0I3; Q9UQN2; Q9Y5K5" "TGF-beta signaling pathway" "UCH proteinases; Downregulation of TGF-beta receptor signaling" "3" "0" "1.043" "0.997" "1.110" "1.054" "1.026" "1.010" "1.006" "1.038" "1.050" "840.6" "877.1" "838.0" "933.1" "886.3" "862.7" "848.7" "845.9" "872.7" "882.9" "" "" "" "" "" "" "" "" "" "" "787.6" "725.8" "778.0" "721.3" "755.5" "824.3" "775.5" "751.0" "872.7" "850.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4848605729142375391" "False" "High" "IsMasterProtein" "P00813" "Adenosine deaminase OS=Homo sapiens OX=9606 GN=ADA PE=1 SV=3" "0.000" "False" "32.270" "31" "12" "17" "12" "363" "40.7" "5.95" "50.75" "12" "cell adhesion;cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00962" "100" "ENSG00000196839" "ADA" "hsa:100; P00813; Q53F92; Q6LA59" "" "Ribavirin ADME; Purine salvage; Defective ADA disrupts (deoxy)adenosine deamination" "3" "0" "0.923" "0.946" "0.897" "0.908" "0.912" "0.889" "0.938" "0.921" "0.902" "2396.8" "2211.6" "2266.2" "2149.3" "2176.3" "2185.7" "2130.9" "2248.2" "2206.4" "2161.1" "" "" "" "" "" "" "" "" "" "" "2245.8" "1830.0" "2103.9" "1661.5" "1855.0" "2088.3" "1947.0" "1996.2" "2206.4" "2080.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6253369152743795153" "False" "High" "IsMasterProtein" "Q8TD16" "Protein bicaudal D homolog 2 OS=Homo sapiens OX=9606 GN=BICD2 PE=1 SV=1" "0.000" "False" "32.256" "13" "11" "12" "11" "824" "93.5" "5.44" "35.81" "11" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf09730" "23299" "ENSG00000185963" "BICD2" "hsa:23299; O75181; Q5TBQ2; Q5TBQ3; Q8TD16; Q96LH2; Q9BT84; Q9H561" "" "COPI-independent Golgi-to-ER retrograde traffic" "1" "0" "1.082" "1.045" "1.078" "1.089" "1.106" "1.051" "1.049" "1.072" "1.092" "1280.8" "1386.4" "1338.7" "1381.0" "1394.7" "1417.2" "1346.2" "1343.0" "1372.5" "1398.8" "" "" "" "" "" "" "" "" "" "" "1200.1" "1147.2" "1242.8" "1067.6" "1188.8" "1354.0" "1230.1" "1192.4" "1372.5" "1346.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6739542972395274555" "False" "High" "IsMasterProtein" "Q9P265" "Disco-interacting protein 2 homolog B OS=Homo sapiens OX=9606 GN=DIP2B PE=1 SV=3" "0.000" "False" "32.141" "8" "12" "14" "12" "1576" "171.4" "8.09" "42.77" "12" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity" "Pf00501, Pf06464" "57609" "ENSG00000066084" "DIP2B" "hsa:57609; Q6B011; Q8N1L5; Q8NB38; Q9P265" "" "" "0" "0" "0.994" "1.022" "0.990" "0.969" "0.973" "0.920" "0.933" "0.913" "0.972" "1488.6" "1480.3" "1520.7" "1473.1" "1441.9" "1448.2" "1369.4" "1388.3" "1359.7" "1446.5" "" "" "" "" "" "" "" "" "" "" "1394.8" "1225.0" "1411.8" "1138.7" "1229.0" "1383.6" "1251.3" "1232.7" "1359.7" "1392.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7367615421387894087" "False" "High" "IsMasterProtein" "Q9Y5X3" "Sorting nexin-5 OS=Homo sapiens OX=9606 GN=SNX5 PE=1 SV=1" "0.000" "False" "32.109" "27" "11" "16" "10" "404" "46.8" "6.76" "47.37" "11" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00787, Pf09325" "27131" "ENSG00000089006" "SNX5" "B7ZKN3; D3DW26; hsa:27131; Q52LC4; Q7KZN0; Q9BWP0; Q9Y5X3" "" "Golgi Associated Vesicle Biogenesis" "1" "1" "0.946" "0.963" "0.988" "0.982" "0.940" "0.930" "0.953" "0.985" "0.951" "2385.2" "2255.4" "2297.8" "2356.0" "2343.1" "2242.9" "2218.9" "2272.4" "2349.8" "2268.4" "" "" "" "" "" "" "" "" "" "" "2234.9" "1866.3" "2133.2" "1821.3" "1997.2" "2142.8" "2027.5" "2017.6" "2349.8" "2184.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6176732133664384368" "False" "High" "IsMasterProtein" "Q70CQ2" "Ubiquitin carboxyl-terminal hydrolase 34 OS=Homo sapiens OX=9606 GN=USP34 PE=1 SV=2" "0.000" "False" "32.085" "4" "11" "13" "11" "3546" "404.0" "5.82" "32.08" "11" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00443, Pf12030" "9736" "ENSG00000115464" "USP34" "A8MWD0; B3KWU9; hsa:9736; O60316; O94834; Q3B777; Q6P6C9; Q70CQ2; Q7L8P6; Q8N3T9; Q8TBW2; Q9UGA1" "" "Ub-specific processing proteases; TCF dependent signaling in response to WNT" "2" "0" "1.077" "1.016" "1.141" "1.038" "1.064" "1.048" "0.978" "0.954" "0.979" "445.0" "479.5" "452.0" "507.7" "461.9" "473.4" "466.4" "435.1" "424.6" "435.6" "" "" "" "" "" "" "" "" "" "" "417.0" "396.7" "419.6" "392.5" "393.7" "452.3" "426.1" "386.3" "424.6" "419.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4137666002023082164" "False" "High" "IsMasterProtein" "Cont_P00761" "Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1" "0.000" "True" "32.077" "43" "7" "79" "7" "231" "24.4" "7.18" "270.25" "7" "protein metabolism;other biological processes" "non-structural extracellular" "other molecular function" "Pf00089" "" "" "" "" "" "" "0" "0" "1.026" "0.899" "1.080" "0.958" "0.969" "0.896" "0.994" "0.948" "0.994" "5976.0" "6128.9" "5374.3" "6453.9" "5727.3" "5793.1" "5354.7" "5941.0" "5665.2" "5938.7" "" "" "" "" "" "" "" "" "" "" "5599.5" "5071.5" "4989.3" "4989.2" "4881.8" "5534.8" "4892.8" "5275.0" "5665.2" "5718.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3384207672428186398" "False" "High" "IsMasterProtein" "Q8N335" "Glycerol-3-phosphate dehydrogenase 1-like protein OS=Homo sapiens OX=9606 GN=GPD1L PE=1 SV=1" "0.000" "False" "32.051" "26" "12" "20" "12" "351" "38.4" "7.02" "61.73" "12" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01210, Pf07479" "23171" "ENSG00000152642" "GPD1L" "A8K9U3; hsa:23171; Q14702; Q8N335; Q9BRM5" "Sudden infant death syndrome (SIDS) susceptibility pathways" "Synthesis of PA" "2" "0" "0.918" "0.937" "0.940" "0.915" "0.954" "0.911" "0.899" "0.927" "0.953" "2542.6" "2334.5" "2383.5" "2390.8" "2325.7" "2425.9" "2316.4" "2284.8" "2357.9" "2422.1" "" "" "" "" "" "" "" "" "" "" "2382.4" "1931.8" "2212.8" "1848.2" "1982.4" "2317.7" "2116.6" "2028.6" "2357.9" "2332.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8980500697727064305" "False" "High" "IsMasterProtein" "O43815" "Striatin OS=Homo sapiens OX=9606 GN=STRN PE=1 SV=4" "0.000" "False" "31.989" "16" "11" "12" "11" "780" "86.1" "5.27" "34.87" "11" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00400, Pf08232" "6801" "ENSG00000115808" "STRN" "hsa:6801; O43815; Q3KP65; Q53TQ8; Q9NP38" "MET in type 1 papillary renal cell carcinoma" "Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins" "8" "0" "1.466" "1.087" "1.077" "1.234" "1.054" "1.172" "1.171" "1.216" "1.092" "1354.3" "1985.9" "1471.6" "1458.0" "1671.0" "1427.9" "1586.6" "1585.4" "1647.5" "1479.1" "" "" "" "" "" "" "" "" "" "" "1269.0" "1643.3" "1366.2" "1127.1" "1424.3" "1364.2" "1449.8" "1407.7" "1647.5" "1424.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5233128446451314475" "False" "High" "IsMasterProtein" "Q8IVD9" "NudC domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NUDCD3 PE=1 SV=3" "0.000" "False" "31.968" "33" "10" "14" "10" "361" "40.8" "5.25" "45.05" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf04969, Pf14050" "23386" "ENSG00000015676" "NUDCD3" "hsa:23386; Q8IVD9; Q9BTI3; Q9H7W9; Q9UPT4" "" "" "0" "0" "0.934" "0.951" "0.926" "0.957" "0.915" "0.913" "0.919" "0.912" "0.930" "1819.3" "1698.7" "1730.8" "1685.4" "1741.5" "1664.1" "1661.7" "1671.8" "1659.0" "1692.3" "" "" "" "" "" "" "" "" "" "" "1704.6" "1405.7" "1606.8" "1302.9" "1484.4" "1589.9" "1518.3" "1484.4" "1659.0" "1629.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2887572586952269824" "False" "High" "IsMasterProtein" "Q9HCE1" "Helicase MOV-10 OS=Homo sapiens OX=9606 GN=MOV10 PE=1 SV=2" "0.000" "False" "31.957" "11" "12" "13" "12" "1003" "113.6" "8.82" "35.99" "12" "stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13086, Pf13087, Pf21632, Pf21633, Pf21634, Pf21635" "4343" "ENSG00000155363" "MOV10" "hsa:4343; Q5JR03; Q8TEF0; Q9BSY3; Q9BUJ9; Q9HCE1" "VEGFA-VEGFR2 signaling" "TP53 Regulates Metabolic Genes; MAPK6/MAPK4 signaling; Oxidative Stress Induced Senescence; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Nuclear events stimulated by ALK signaling in cancer; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "19" "0" "0.980" "1.009" "1.053" "0.978" "0.948" "0.897" "0.863" "0.872" "0.989" "396.0" "387.9" "399.6" "417.0" "387.3" "375.2" "355.2" "341.6" "345.3" "391.5" "" "" "" "" "" "" "" "" "" "" "371.0" "321.0" "371.0" "322.4" "330.1" "358.5" "324.5" "303.3" "345.3" "376.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4173136633731686100" "False" "High" "IsMasterProtein" "P29590" "Protein PML OS=Homo sapiens OX=9606 GN=PML PE=1 SV=3" "0.000" "False" "31.935" "10" "10" "13" "10" "882" "97.5" "6.21" "43.92" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097, Pf00643, Pf12126" "5371" "ENSG00000140464" "PML" "E9PBR7; hsa:5371; P29590; P29591; P29592; P29593; Q00755; Q15959; Q59FP9; Q8WUA0; Q96S41; Q9BPW2; Q9BWP7; Q9BZX6; Q9BZX7; Q9BZX8; Q9BZX9; Q9BZY0; Q9BZY2; Q9BZY3" "miRNA regulation of DNA damage response; Wnt/beta-catenin signaling pathway in leukemia; TGF-beta signaling pathway; p53 transcriptional gene network; Acute myeloid leukemia; DNA damage response" "HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Interferon gamma signaling; Regulation of TP53 Activity through Acetylation; Regulation of PTEN localization; Regulation of RUNX1 Expression and Activity" "13" "0" "1.032" "1.015" "1.068" "1.068" "1.103" "1.076" "1.051" "1.096" "1.070" "1003.3" "1035.2" "1017.9" "1071.0" "1071.5" "1106.7" "1079.7" "1054.1" "1099.7" "1073.8" "" "" "" "" "" "" "" "" "" "" "940.1" "856.6" "945.0" "827.9" "913.3" "1057.4" "986.6" "935.9" "1099.7" "1033.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3827413943900730422" "False" "High" "IsMasterProtein" "Q9Y2W2" "WW domain-binding protein 11 OS=Homo sapiens OX=9606 GN=WBP11 PE=1 SV=1" "0.000" "False" "31.916" "19" "11" "13" "11" "641" "70.0" "8.38" "42.26" "11" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09429" "51729" "ENSG00000084463" "WBP11" "hsa:51729; Q96AY8; Q9Y2W2" "" "mRNA Splicing - Major Pathway" "1" "0" "1.025" "1.088" "1.046" "1.083" "1.060" "1.048" "1.156" "1.092" "1.024" "2094.9" "2146.4" "2280.2" "2190.7" "2269.4" "2220.7" "2195.0" "2421.2" "2288.2" "2144.2" "" "" "" "" "" "" "" "" "" "" "1963.0" "1776.1" "2116.9" "1693.5" "1934.4" "2121.7" "2005.7" "2149.8" "2288.2" "2064.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5413684009215812555" "False" "High" "IsMasterProtein" "O15143" "Actin-related protein 2/3 complex subunit 1B OS=Homo sapiens OX=9606 GN=ARPC1B PE=1 SV=3" "0.000" "False" "31.899" "28" "9" "15" "9" "372" "40.9" "8.35" "55.68" "9" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400" "10095" "ENSG00000130429" "ARPC1B" "hsa:10095; O15143; Q9BU00" "Pathogenic Escherichia coli infection; Microglia pathogen phagocytosis pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling" "6" "0" "1.121" "1.025" "1.001" "1.047" "1.038" "0.966" "1.021" "1.078" "1.053" "1932.1" "2165.6" "1980.6" "1934.2" "2023.2" "2004.8" "1865.6" "1973.1" "2082.1" "2034.0" "" "" "" "" "" "" "" "" "" "" "1810.3" "1792.0" "1838.7" "1495.2" "1724.5" "1915.4" "1704.6" "1751.9" "2082.1" "1958.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4414098033661647234" "False" "High" "IsMasterProtein" "O43488" "Aflatoxin B1 aldehyde reductase member 2 OS=Homo sapiens OX=9606 GN=AKR7A2 PE=1 SV=3" "0.000" "False" "31.895" "29" "9" "16" "9" "359" "39.6" "7.17" "47.93" "9" "other metabolic processes" "cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00248" "8574" "ENSG00000053371" "AKR7A2" "hsa:8574; O43488; O75749; Q5TG63" "Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II" "Aflatoxin activation and detoxification" "3" "0" "1.010" "0.971" "0.919" "0.937" "0.953" "0.908" "0.975" "0.926" "0.921" "2480.4" "2505.0" "2409.4" "2279.1" "2324.0" "2363.7" "2252.7" "2419.3" "2297.9" "2285.4" "" "" "" "" "" "" "" "" "" "" "2324.2" "2072.8" "2236.8" "1761.9" "1980.9" "2258.3" "2058.4" "2148.1" "2297.9" "2200.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6570966043889327404" "False" "High" "IsMasterProtein" "Q15437" "Protein transport protein Sec23B OS=Homo sapiens OX=9606 GN=SEC23B PE=1 SV=2" "0.000" "False" "31.886" "16" "11" "13" "10" "767" "86.4" "6.89" "37.04" "11" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10483" "ENSG00000101310" "SEC23B" "D3DW33; hsa:10483; Q15437; Q503A9; Q5W183; Q9BS15; Q9BSI2; Q9H1D7" "Sterol regulatory element-binding proteins (SREBP) signaling" "" "1" "0" "0.967" "1.011" "1.012" "1.040" "1.022" "0.959" "0.969" "0.973" "0.997" "950.1" "918.6" "960.5" "961.4" "988.5" "971.3" "911.2" "921.0" "924.9" "946.9" "" "" "" "" "" "" "" "" "" "" "890.3" "760.1" "891.7" "743.2" "842.6" "928.0" "832.6" "817.7" "924.9" "911.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "52020500018808800" "False" "High" "IsMasterProtein" "Q9H773" "dCTP pyrophosphatase 1 OS=Homo sapiens OX=9606 GN=DCTPP1 PE=1 SV=1" "0.000" "False" "31.809" "55" "9" "18" "9" "170" "18.7" "5.03" "51.66" "9" "DNA metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf12643" "79077" "ENSG00000179958" "DCTPP1" "hsa:79077; Q9H773" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "1.082" "0.958" "1.108" "1.019" "0.951" "1.095" "1.010" "0.970" "0.997" "1270.5" "1374.3" "1217.0" "1407.8" "1295.2" "1208.3" "1390.9" "1283.5" "1231.8" "1266.8" "" "" "" "" "" "" "" "" "" "" "1190.5" "1137.2" "1129.8" "1088.3" "1104.0" "1154.4" "1270.9" "1139.7" "1231.8" "1219.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5339836283997496681" "False" "High" "IsMasterProtein" "O95163" "Elongator complex protein 1 OS=Homo sapiens OX=9606 GN=ELP1 PE=1 SV=3" "0.000" "False" "31.718" "9" "11" "14" "11" "1332" "150.2" "5.94" "43.49" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04762" "8518" "ENSG00000070061" "ELP1" "hsa:8518; O95163; Q5JSV2; Q9H327; Q9UG87" "HDAC6 interactions in the central nervous system" "HATs acetylate histones" "2" "0" "1.005" "0.974" "1.075" "1.008" "0.979" "0.979" "0.936" "0.969" "0.984" "831.9" "836.2" "810.3" "894.0" "838.4" "814.1" "814.2" "778.9" "806.3" "818.4" "" "" "" "" "" "" "" "" "" "" "779.5" "692.0" "752.3" "691.1" "714.7" "777.8" "744.0" "691.6" "806.3" "788.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4968571585111953171" "False" "High" "IsMasterProtein" "P55036" "26S proteasome non-ATPase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMD4 PE=1 SV=1" "0.000" "False" "31.708" "29" "8" "13" "8" "377" "40.7" "4.79" "43.67" "8" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02809, Pf13519" "5710" "ENSG00000159352" "PSMD4" "D3DV16; hsa:5710; P55036; Q5VWC5; Q9NS92" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling; Alzheimer's disease" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; SCF(Skp2)-mediated degradation of p27/p21; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Ub-specific processing proteases; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "1.007" "1.001" "0.988" "1.023" "1.008" "0.972" "0.963" "0.964" "0.985" "1376.1" "1385.4" "1378.1" "1359.7" "1407.5" "1386.8" "1337.0" "1325.5" "1325.9" "1355.2" "" "" "" "" "" "" "" "" "" "" "1289.4" "1146.4" "1279.4" "1051.1" "1199.7" "1325.0" "1221.6" "1176.9" "1325.9" "1304.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6175620915795625691" "False" "High" "IsMasterProtein" "Q13151" "Heterogeneous nuclear ribonucleoprotein A0 OS=Homo sapiens OX=9606 GN=HNRNPA0 PE=1 SV=1" "0.000" "False" "31.698" "31" "8" "33" "7" "305" "30.8" "9.29" "102.72" "8" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "10949" "ENSG00000177733" "HNRNPA0" "hsa:10949; Q13151; Q6IB18" "" "" "0" "0" "0.978" "1.013" "0.928" "0.992" "0.998" "0.927" "0.969" "0.969" "0.997" "1895.5" "1854.1" "1920.9" "1758.4" "1881.1" "1891.9" "1757.9" "1836.9" "1837.0" "1890.7" "" "" "" "" "" "" "" "" "" "" "1776.1" "1534.2" "1783.4" "1359.3" "1603.4" "1807.5" "1606.3" "1631.0" "1837.0" "1820.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8155016399758939464" "False" "High" "IsMasterProtein" "Q9UNS1" "Protein timeless homolog OS=Homo sapiens OX=9606 GN=TIMELESS PE=1 SV=2" "0.000" "False" "31.692" "10" "11" "14" "11" "1208" "138.6" "5.40" "40.53" "11" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04821, Pf05029" "8914" "ENSG00000111602" "TIMELESS" "B2ZAV0; hsa:8914; O94802; Q86VM1; Q8IWH3; Q9UNS1" "" "Processing of DNA double-strand break ends" "1" "0" "1.030" "1.022" "1.051" "1.053" "1.015" "1.038" "0.997" "0.986" "1.046" "1186.5" "1222.6" "1212.8" "1247.2" "1249.0" "1204.4" "1232.1" "1182.7" "1169.7" "1240.7" "" "" "" "" "" "" "" "" "" "" "1111.8" "1011.7" "1125.9" "964.2" "1064.6" "1150.6" "1125.8" "1050.1" "1169.7" "1194.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4027474892696141167" "False" "High" "IsMasterProtein" "Q9BZI7" "Regulator of nonsense transcripts 3B OS=Homo sapiens OX=9606 GN=UPF3B PE=1 SV=1" "0.000" "False" "31.635" "22" "11" "16" "11" "483" "57.7" "9.48" "40.96" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf03467" "65109" "ENSG00000125351" "UPF3B" "D3DWI3; D3DWI4; hsa:65109; Q0VAK8; Q9BZI7; Q9H1J0" "" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing" "6" "0" "1.088" "1.053" "1.105" "1.101" "1.071" "1.045" "1.026" "1.051" "1.082" "1399.5" "1522.3" "1473.5" "1547.2" "1540.9" "1499.5" "1461.9" "1435.9" "1470.9" "1514.1" "" "" "" "" "" "" "" "" "" "" "1311.4" "1259.7" "1367.9" "1196.0" "1313.4" "1432.6" "1335.8" "1274.9" "1470.9" "1457.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2746041825889845794" "False" "High" "IsMasterProtein" "Q15059" "Bromodomain-containing protein 3 OS=Homo sapiens OX=9606 GN=BRD3 PE=1 SV=1" "0.000" "False" "31.606" "13" "11" "13" "7" "726" "79.5" "9.36" "41.75" "11" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf00439, Pf17035" "8019" "ENSG00000169925" "BRD3" "B1APD9; hsa:8019; Q15059; Q4G5Y3; Q5T1R7; Q8N5M3; Q92645" "" "" "0" "1" "0.944" "1.054" "0.987" "1.063" "1.063" "1.017" "1.067" "1.018" "1.028" "1097.9" "1036.6" "1157.4" "1083.7" "1166.7" "1167.3" "1117.1" "1172.0" "1117.6" "1128.6" "" "" "" "" "" "" "" "" "" "" "1028.7" "857.8" "1074.5" "837.7" "994.5" "1115.2" "1020.7" "1040.6" "1117.6" "1086.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4463024331811541084" "False" "High" "IsMasterProtein" "Q15054" "DNA polymerase delta subunit 3 OS=Homo sapiens OX=9606 GN=POLD3 PE=1 SV=2" "0.000" "False" "31.593" "23" "11" "12" "11" "466" "51.4" "9.35" "39.81" "11" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf09507" "10714" "ENSG00000077514" "POLD3" "B7ZAI6; hsa:10714; Q15054; Q32MZ9; Q32N00" "Homologous recombination; Retinoblastoma gene in cancer; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "26" "0" "1.044" "1.011" "0.972" "1.017" "1.005" "0.978" "0.877" "1.020" "1.030" "1751.0" "1828.5" "1770.0" "1701.6" "1781.0" "1760.3" "1712.2" "1535.8" "1786.2" "1802.7" "" "" "" "" "" "" "" "" "" "" "1640.6" "1513.0" "1643.2" "1315.4" "1518.0" "1681.8" "1564.5" "1363.6" "1786.2" "1735.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6447964159336659836" "False" "High" "IsMasterProtein" "Q9UL15" "BAG family molecular chaperone regulator 5 OS=Homo sapiens OX=9606 GN=BAG5 PE=1 SV=1" "0.000" "False" "31.588" "25" "10" "12" "10" "447" "51.2" "6.05" "37.52" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf02179" "9529" "ENSG00000166170" "BAG5" "hsa:9529; O94950; Q86W59; Q9UL15" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "0.993" "1.051" "1.063" "1.049" "1.080" "1.065" "1.054" "1.060" "1.016" "1370.3" "1360.8" "1439.8" "1456.7" "1437.3" "1479.4" "1459.3" "1444.8" "1452.3" "1392.3" "" "" "" "" "" "" "" "" "" "" "1284.0" "1126.0" "1336.7" "1126.1" "1225.1" "1413.5" "1333.4" "1282.8" "1452.3" "1340.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2192359693732382121" "False" "High" "IsMasterProtein" "O95433" "Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Homo sapiens OX=9606 GN=AHSA1 PE=1 SV=1" "0.000" "False" "31.573" "33" "11" "15" "11" "338" "38.3" "5.53" "50.20" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi" "other molecular function" "Pf08327, Pf09229" "10598" "ENSG00000100591" "AHSA1" "B2R9L2; B4DUR9; hsa:10598; O95433; Q96IL6; Q9P060" "T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection" "" "1" "0" "0.957" "0.979" "0.952" "0.951" "0.953" "0.930" "0.954" "0.966" "0.939" "3547.4" "3394.5" "3474.6" "3377.6" "3375.3" "3381.7" "3299.5" "3385.8" "3425.6" "3332.4" "" "" "" "" "" "" "" "" "" "" "3323.9" "2808.9" "3225.7" "2611.0" "2877.0" "3230.9" "3014.9" "3006.3" "3425.6" "3208.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516272036315922492" "False" "High" "IsMasterProtein" "Q15637" "Splicing factor 1 OS=Homo sapiens OX=9606 GN=SF1 PE=1 SV=4" "0.000" "False" "31.544" "19" "9" "13" "9" "639" "68.3" "8.98" "47.12" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00098, Pf16275" "7536" "ENSG00000168066" "SF1" "B7Z1Q1; C9JJE2; hsa:7536; Q14818; Q14819; Q15637; Q15913; Q8IY00; Q92744; Q92745; Q969H7; Q9BW01; Q9UEI0" "" "mRNA Splicing - Major Pathway" "1" "0" "1.018" "0.999" "1.116" "1.056" "1.000" "1.089" "1.116" "1.050" "1.040" "1560.6" "1588.7" "1559.5" "1741.5" "1648.3" "1559.9" "1698.9" "1742.0" "1639.0" "1623.1" "" "" "" "" "" "" "" "" "" "" "1462.3" "1314.6" "1447.8" "1346.3" "1405.0" "1490.4" "1552.4" "1546.7" "1639.0" "1562.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3544092344489090561" "False" "High" "IsMasterProtein" "Q8TB72" "Pumilio homolog 2 OS=Homo sapiens OX=9606 GN=PUM2 PE=1 SV=2" "0.000" "False" "31.538" "11" "11" "12" "7" "1066" "114.1" "7.08" "38.71" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00806" "23369" "ENSG00000055917" "PUM2" "B3KSL0; B4E2B6; D6W527; hsa:23369; O00234; Q53TV7; Q8TB72; Q8WY43; Q9HAN2" "Male infertility" "Neddylation" "2" "0" "1.078" "1.089" "1.073" "1.102" "1.117" "0.932" "0.910" "0.956" "1.022" "772.7" "833.2" "841.3" "829.3" "851.6" "862.7" "720.4" "703.0" "738.6" "789.6" "" "" "" "" "" "" "" "" "" "" "724.0" "689.5" "781.0" "641.1" "725.9" "824.2" "658.3" "624.2" "738.6" "760.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5035986382802710418" "False" "High" "IsMasterProtein" "Q9NUB1" "Acetyl-coenzyme A synthetase 2-like, mitochondrial OS=Homo sapiens OX=9606 GN=ACSS1 PE=1 SV=2" "0.000" "False" "31.479" "18" "11" "14" "11" "689" "74.8" "7.11" "46.73" "11" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00501, Pf13193, Pf16177" "84532" "ENSG00000154930" "ACSS1" "B3KXL2; B4DJZ3; D3DW48; F5H6F4; F8W7Y1; hsa:84532; Q5TF42; Q8IV99; Q8N234; Q96JI1; Q96JX6; Q9NU28; Q9NUB1" "Sterol regulatory element-binding proteins (SREBP) signaling; Amino acid metabolism; Statin inhibition of cholesterol production; Familial hyperlipidemia type 4" "Ethanol oxidation" "5" "0" "0.984" "0.998" "0.960" "0.983" "1.062" "0.917" "1.040" "1.042" "1.012" "1533.7" "1509.1" "1530.4" "1472.2" "1507.1" "1629.0" "1406.8" "1595.3" "1598.8" "1552.3" "" "" "" "" "" "" "" "" "" "" "1437.1" "1248.7" "1420.7" "1138.1" "1284.6" "1556.4" "1285.5" "1416.5" "1598.8" "1494.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3460049962588220827" "False" "High" "IsMasterProtein" "Q96CX2" "BTB/POZ domain-containing protein KCTD12 OS=Homo sapiens OX=9606 GN=KCTD12 PE=1 SV=1" "0.000" "False" "31.470" "33" "9" "11" "9" "325" "35.7" "5.64" "36.36" "9" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf02214" "115207" "ENSG00000178695" "KCTD12" "hsa:115207; Q96CX2" "" "" "0" "0" "1.157" "1.142" "1.196" "1.201" "1.053" "1.223" "1.082" "1.069" "1.024" "450.8" "521.4" "514.7" "538.9" "541.3" "474.8" "551.4" "487.6" "482.0" "461.8" "" "" "" "" "" "" "" "" "" "" "422.4" "431.4" "477.8" "416.6" "461.4" "453.6" "503.9" "433.0" "482.0" "444.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3220209801310809840" "False" "High" "IsMasterProtein" "P60891" "Ribose-phosphate pyrophosphokinase 1 OS=Homo sapiens OX=9606 GN=PRPS1 PE=1 SV=2" "0.000" "False" "31.468" "37" "11" "15" "5" "318" "34.8" "6.98" "47.03" "11" "other metabolic processes;developmental processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf13793, Pf14572" "5631" "ENSG00000147224" "PRPS1" "B1ALA8; B2R6T7; B4DNL6; D3DUX6; hsa:5631; P09329; P60891" "" "5-Phosphoribose 1-diphosphate biosynthesis" "1" "3" "0.962" "0.976" "1.027" "0.968" "0.916" "0.944" "0.974" "0.922" "0.898" "836.0" "804.0" "816.2" "858.4" "809.5" "765.9" "789.6" "814.1" "770.6" "750.7" "" "" "" "" "" "" "" "" "" "" "783.3" "665.3" "757.7" "663.6" "690.0" "731.8" "721.5" "722.8" "770.6" "722.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5939378456610215612" "False" "High" "IsMasterProtein" "O95819" "Mitogen-activated protein kinase kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP4K4 PE=1 SV=2" "0.000" "False" "31.457" "10" "11" "14" "8" "1239" "142.0" "7.46" "47.79" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00780" "9448" "ENSG00000071054" "MAP4K4" "E7ESS2; hsa:9448; O75172; O95819; Q9NST7" "MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Pleural mesothelioma" "Oxidative Stress Induced Senescence" "7" "0" "1.074" "1.042" "1.085" "1.031" "1.006" "1.072" "0.994" "0.969" "1.027" "827.5" "889.0" "862.0" "898.2" "852.9" "832.1" "887.0" "822.9" "801.8" "850.1" "" "" "" "" "" "" "" "" "" "" "775.4" "735.6" "800.2" "694.4" "727.0" "795.0" "810.4" "730.7" "801.8" "818.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-573717286669998035" "False" "High" "IsMasterProtein" "Q9BY43" "Charged multivesicular body protein 4a OS=Homo sapiens OX=9606 GN=CHMP4A PE=1 SV=3" "0.000" "False" "31.449" "40" "10" "11" "10" "222" "25.1" "4.70" "42.10" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "29082" "ENSG00000254505; ENSG00000285302" "CHMP4A" "hsa:29082; Q14D22; Q32Q79; Q86SZ8; Q96QJ9; Q9BY43; Q9P026" "" "HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "9" "0" "1.001" "0.945" "0.976" "1.001" "1.011" "0.977" "1.018" "0.975" "0.980" "1939.2" "1941.0" "1833.1" "1892.6" "1941.6" "1961.3" "1894.8" "1974.3" "1891.6" "1901.0" "" "" "" "" "" "" "" "" "" "" "1817.0" "1606.2" "1701.8" "1463.1" "1655.0" "1873.8" "1731.4" "1753.0" "1891.6" "1830.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1538896593466497334" "False" "High" "IsMasterProtein" "P23528" "Cofilin-1 OS=Homo sapiens OX=9606 GN=CFL1 PE=1 SV=3" "0.000" "False" "31.440" "55" "10" "19" "10" "166" "18.5" "8.09" "67.55" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00241" "1072" "ENSG00000172757" "CFL1" "B3KUQ1; hsa:1072; P23528; Q53Y87; Q9UCA2" "Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; 7q11.23 copy number variation syndrome; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "Platelet degranulation ; Regulation of actin dynamics for phagocytic cup formation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; EPHB-mediated forward signaling; Sema3A PAK dependent Axon repulsion; RHO GTPases Activate ROCKs" "15" "0" "1.133" "1.028" "0.847" "0.960" "0.966" "0.885" "0.968" "1.019" "0.960" "2290.1" "2594.3" "2354.5" "1938.6" "2198.3" "2212.3" "2025.7" "2217.2" "2332.8" "2197.7" "" "" "" "" "" "" "" "" "" "" "2145.8" "2146.7" "2185.9" "1498.6" "1873.8" "2113.6" "1851.0" "1968.7" "2332.8" "2116.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "152076562272560972" "False" "High" "IsMasterProtein" "Q13409" "Cytoplasmic dynein 1 intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1I2 PE=1 SV=3" "0.000" "False" "31.416" "19" "10" "11" "10" "638" "71.4" "5.20" "39.83" "10" "transport;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf11540" "1781" "ENSG00000077380; ENSG00000292102" "DYNC1I2" "B7ZA04; D3DPD4; D3DPD5; D3DPD6; hsa:1781; Q13409; Q32LY9; Q53S84; Q5BJF8; Q7Z4X1; Q96NG7; Q96S87; Q9BXZ5; Q9NT58" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption; HDAC6 interactions in the central nervous system" "HCMV Early Events; Separation of Sister Chromatids; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "23" "0" "1.005" "1.004" "0.968" "0.998" "0.978" "0.893" "1.013" "0.984" "0.995" "1114.6" "1120.2" "1119.1" "1078.5" "1112.5" "1090.2" "995.0" "1128.6" "1096.5" "1109.1" "" "" "" "" "" "" "" "" "" "" "1044.4" "927.0" "1039.0" "833.7" "948.2" "1041.5" "909.2" "1002.0" "1096.5" "1067.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5318017384069718868" "False" "High" "IsMasterProtein" "Q9Y5B0" "RNA polymerase II subunit A C-terminal domain phosphatase OS=Homo sapiens OX=9606 GN=CTDP1 PE=1 SV=3" "0.000" "False" "31.414" "12" "11" "13" "11" "961" "104.3" "5.27" "40.60" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00533, Pf03031, Pf09309" "9150" "ENSG00000060069" "CTDP1" "A8MY97; hsa:9150; Q7Z644; Q96BZ1; Q9Y5B0; Q9Y6F5" "" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "14" "0" "1.065" "1.061" "1.063" "1.093" "1.086" "1.067" "0.975" "0.987" "1.082" "812.5" "865.6" "861.8" "863.9" "887.9" "882.0" "867.0" "791.9" "802.2" "879.2" "" "" "" "" "" "" "" "" "" "" "761.3" "716.2" "800.1" "667.9" "756.8" "842.7" "792.2" "703.1" "802.2" "846.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8764284085983728716" "False" "High" "IsMasterProtein" "P18583" "Protein SON OS=Homo sapiens OX=9606 GN=SON PE=1 SV=4" "0.000" "False" "31.406" "5" "11" "13" "11" "2426" "263.7" "5.64" "36.32" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf01585, Pf14709, Pf17069" "6651" "ENSG00000159140" "SON" "D3DSF5; D3DSF6; E7ETE8; E7EU67; E7EVW3; E9PFQ2; hsa:6651; O14487; O95981; P18583; Q14120; Q6PKE0; Q9H7B1; Q9P070; Q9P072; Q9UKP9; Q9UPY0" "" "" "0" "0" "1.093" "1.020" "1.207" "1.189" "1.221" "1.416" "1.481" "1.429" "1.267" "1298.8" "1419.6" "1324.6" "1567.5" "1544.9" "1585.6" "1839.4" "1923.0" "1855.7" "1645.8" "" "" "" "" "" "" "" "" "" "" "1217.0" "1174.7" "1229.7" "1211.7" "1316.8" "1514.9" "1680.7" "1707.4" "1855.7" "1584.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4257899417113298170" "False" "High" "IsMasterProtein" "P78316" "Nucleolar protein 14 OS=Homo sapiens OX=9606 GN=NOP14 PE=1 SV=3" "0.000" "False" "31.365" "13" "11" "12" "11" "857" "97.6" "7.58" "35.17" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04147" "8602" "ENSG00000087269" "NOP14" "D3DVR6; hsa:8602; P78316; Q7LGI5; Q7Z6K0; Q8TBR6" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.965" "0.966" "0.966" "1.024" "0.991" "1.120" "1.117" "1.092" "1.063" "1790.0" "1727.8" "1729.7" "1729.7" "1832.8" "1773.8" "2005.4" "1999.5" "1954.1" "1901.9" "" "" "" "" "" "" "" "" "" "" "1677.3" "1429.7" "1605.8" "1337.1" "1562.3" "1694.7" "1832.4" "1775.4" "1954.1" "1831.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8165115417245555276" "False" "High" "IsMasterProtein" "Q15293" "Reticulocalbin-1 OS=Homo sapiens OX=9606 GN=RCN1 PE=1 SV=1" "0.000" "False" "31.354" "34" "10" "18" "10" "331" "38.9" "5.00" "56.47" "10" "developmental processes" "ER/Golgi" "other molecular function" "Pf13202" "5954" "ENSG00000049449" "RCN1" "B7Z1M1; D3DR00; hsa:5954; Q15293" "VEGFA-VEGFR2 signaling" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "3" "0" "0.994" "0.968" "0.942" "0.978" "0.972" "0.961" "0.951" "0.909" "0.936" "2082.7" "2070.7" "2016.6" "1961.3" "2037.8" "2024.5" "2001.8" "1980.3" "1893.0" "1950.0" "" "" "" "" "" "" "" "" "" "" "1951.5" "1713.5" "1872.2" "1516.2" "1737.0" "1934.2" "1829.1" "1758.3" "1893.0" "1877.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1348431233397446306" "False" "High" "IsMasterProtein" "P62495" "Eukaryotic peptide chain release factor subunit 1 OS=Homo sapiens OX=9606 GN=ETF1 PE=1 SV=3" "0.000" "False" "31.318" "23" "9" "20" "9" "437" "49.0" "5.71" "57.57" "9" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf03463, Pf03464, Pf03465" "2107" "ENSG00000120705" "ETF1" "B2R6B4; D3DQC1; hsa:2107; P46055; P62495; Q5M7Z7; Q96CG1" "Translation factors" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Protein hydroxylation" "6" "0" "0.962" "1.022" "1.131" "1.015" "1.033" "1.063" "1.059" "1.028" "0.994" "781.9" "752.6" "798.7" "884.2" "793.7" "807.4" "831.3" "828.1" "803.6" "777.4" "" "" "" "" "" "" "" "" "" "" "732.6" "622.7" "741.5" "683.5" "676.6" "771.4" "759.6" "735.3" "803.6" "748.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2595781739747339031" "False" "High" "IsMasterProtein" "Q14677" "Clathrin interactor 1 OS=Homo sapiens OX=9606 GN=CLINT1 PE=1 SV=1" "0.000" "False" "31.296" "19" "11" "13" "11" "625" "68.2" "6.42" "44.24" "11" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01417" "9685" "ENSG00000113282" "CLINT1" "B7Z6F8; D3DQJ6; hsa:9685; Q14677; Q8NAF1; Q96E05" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "1.086" "1.053" "1.007" "1.145" "1.135" "1.124" "1.229" "1.232" "1.144" "1320.6" "1434.3" "1390.8" "1330.4" "1512.7" "1499.3" "1483.8" "1623.6" "1627.5" "1511.3" "" "" "" "" "" "" "" "" "" "" "1237.4" "1186.8" "1291.1" "1028.5" "1289.3" "1432.5" "1355.8" "1441.6" "1627.5" "1455.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5479844659917987073" "False" "High" "IsMasterProtein" "Q9NQ48" "Leucine zipper transcription factor-like protein 1 OS=Homo sapiens OX=9606 GN=LZTFL1 PE=1 SV=1" "0.000" "False" "31.285" "32" "9" "11" "9" "299" "34.6" "5.36" "41.97" "9" "other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf15294" "54585" "ENSG00000163818" "LZTFL1" "B3KSI9; B4E0K7; hsa:54585; Q8TC61; Q9NQ48; Q9NQ56" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies; Bardet-Biedl syndrome" "BBSome-mediated cargo-targeting to cilium" "5" "0" "1.013" "0.985" "1.045" "1.017" "1.035" "0.966" "0.992" "1.021" "0.990" "1431.5" "1449.8" "1409.3" "1495.3" "1456.5" "1481.7" "1383.0" "1420.3" "1461.4" "1417.1" "" "" "" "" "" "" "" "" "" "" "1341.3" "1199.7" "1308.4" "1155.9" "1241.5" "1415.6" "1263.7" "1261.1" "1461.4" "1364.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8995832376771225777" "False" "High" "IsMasterProtein" "Q9UBS4" "DnaJ homolog subfamily B member 11 OS=Homo sapiens OX=9606 GN=DNAJB11 PE=1 SV=1" "0.000" "False" "31.283" "33" "10" "11" "10" "358" "40.5" "6.18" "41.14" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00226, Pf01556" "51726" "ENSG00000090520" "DNAJB11" "hsa:51726; Q542Y5; Q542Y9; Q6IAQ8; Q96JC6; Q9UBS4" "Photodynamic therapy-induced unfolded protein response" "XBP1(S) activates chaperone genes" "2" "0" "1.066" "1.011" "0.952" "1.018" "1.038" "0.969" "0.993" "0.955" "1.017" "1673.7" "1783.7" "1691.5" "1593.8" "1703.1" "1737.6" "1621.6" "1662.1" "1598.4" "1702.7" "" "" "" "" "" "" "" "" "" "" "1568.2" "1476.0" "1570.4" "1232.1" "1451.7" "1660.1" "1481.7" "1475.7" "1598.4" "1639.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7598274604461767952" "False" "High" "IsMasterProtein" "P49750" "YLP motif-containing protein 1 OS=Homo sapiens OX=9606 GN=YLPM1 PE=1 SV=4" "0.000" "False" "31.276" "5" "12" "14" "12" "2146" "241.5" "6.55" "32.82" "12" "other biological processes" "nucleus" "" "Pf13671" "56252" "ENSG00000119596" "YLPM1" "hsa:56252; P49750; P49752; Q96I64; Q9P1V7" "" "" "0" "0" "1.123" "1.089" "1.195" "1.175" "1.124" "1.258" "1.348" "1.323" "1.185" "460.3" "516.9" "501.1" "550.0" "541.0" "517.4" "578.9" "620.6" "609.1" "545.3" "" "" "" "" "" "" "" "" "" "" "431.3" "427.7" "465.2" "425.2" "461.2" "494.3" "529.0" "551.0" "609.1" "525.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5102173735616793815" "False" "High" "IsMasterProtein" "Q9BWH6" "RNA polymerase II-associated protein 1 OS=Homo sapiens OX=9606 GN=RPAP1 PE=1 SV=3" "0.000" "False" "31.275" "8" "11" "14" "11" "1393" "152.7" "6.38" "43.34" "11" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08620, Pf08621" "26015" "ENSG00000103932" "RPAP1" "hsa:26015; Q9BWH6; Q9H9I2; Q9NSQ5; Q9P2E4; Q9UFS7" "" "" "0" "0" "1.007" "0.971" "1.057" "0.999" "0.995" "1.012" "0.940" "0.980" "0.968" "664.1" "668.9" "644.8" "702.2" "663.1" "660.9" "672.1" "624.5" "650.7" "643.2" "" "" "" "" "" "" "" "" "" "" "622.3" "553.5" "598.6" "542.9" "565.2" "631.4" "614.2" "554.5" "650.7" "619.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8506961570143965113" "False" "High" "IsMasterProtein" "Q99497" "Parkinson disease protein 7 OS=Homo sapiens OX=9606 GN=PARK7 PE=1 SV=2" "0.000" "False" "31.264" "53" "10" "18" "10" "189" "19.9" "6.79" "53.60" "10" "cell-cell signaling;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01965" "11315" "ENSG00000116288" "PARK7" "B2R4Z1; hsa:11315; O14805; Q6DR95; Q7LFU2; Q99497" "Androgen receptor signaling pathway; Synaptic vesicle pathway; Parkinson's disease pathway; HDAC6 interactions in the central nervous system" "Late endosomal microautophagy; Aggrephagy; SUMOylation of transcription cofactors; Chaperone Mediated Autophagy" "8" "0" "1.019" "0.985" "1.009" "0.990" "0.946" "0.945" "0.956" "0.949" "0.951" "1684.8" "1716.9" "1658.9" "1699.8" "1668.5" "1593.5" "1591.8" "1610.4" "1599.5" "1601.8" "" "" "" "" "" "" "" "" "" "" "1578.6" "1420.7" "1540.1" "1314.1" "1422.2" "1522.4" "1454.4" "1429.9" "1599.5" "1542.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3069559242831628546" "False" "High" "IsMasterProtein" "Q7Z460" "CLIP-associating protein 1 OS=Homo sapiens OX=9606 GN=CLASP1 PE=1 SV=1" "0.000" "False" "31.248" "8" "12" "13" "9" "1538" "169.3" "9.03" "36.47" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf02985, Pf12348, Pf21040" "23332" "ENSG00000074054" "CLASP1" "A2RU21; B7ZLX3; F5GWS0; hsa:23332; O75118; Q2KHQ9; Q5H9P0; Q7Z460; Q8N5B8; Q9BQT5" "Microtubule cytoskeleton regulation; Splicing factor NOVA regulated synaptic proteins; 7q11.23 copy number variation syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Role of ABL in ROBO-SLIT signaling" "17" "1" "1.009" "1.029" "1.043" "1.038" "1.094" "0.992" "1.033" "0.956" "1.035" "1115.7" "1125.2" "1148.3" "1163.4" "1158.1" "1220.7" "1106.6" "1152.4" "1066.9" "1155.1" "" "" "" "" "" "" "" "" "" "" "1045.4" "931.1" "1066.1" "899.3" "987.1" "1166.2" "1011.2" "1023.2" "1066.9" "1112.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3253297407861631258" "False" "High" "IsMasterProtein" "O95155" "Ubiquitin conjugation factor E4 B OS=Homo sapiens OX=9606 GN=UBE4B PE=1 SV=1" "0.000" "False" "31.219" "9" "11" "12" "11" "1302" "146.1" "6.55" "40.68" "11" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04564, Pf10408" "10277" "ENSG00000130939" "UBE4B" "A8K8S9; G0ZJH6; O75169; O95155; O95338; Q5SZ12; Q5SZ16; Q96QD4; Q9BYI7" "" "" "0" "0" "1.038" "0.976" "1.110" "0.972" "0.993" "1.061" "0.956" "0.986" "1.018" "1017.2" "1055.5" "992.7" "1129.6" "988.4" "1010.1" "1078.9" "972.4" "1003.2" "1035.7" "" "" "" "" "" "" "" "" "" "" "953.1" "873.4" "921.6" "873.2" "842.5" "965.1" "985.8" "863.4" "1003.2" "997.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3632960594176974073" "False" "High" "IsMasterProtein" "Q9UPN9" "E3 ubiquitin-protein ligase TRIM33 OS=Homo sapiens OX=9606 GN=TRIM33 PE=1 SV=3" "0.000" "False" "31.140" "9" "10" "15" "9" "1127" "122.5" "6.67" "44.95" "10" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf00643" "51592" "ENSG00000197323" "TRIM33" "hsa:51592; O95855; Q5TG72; Q5TG73; Q5TG74; Q9C017; Q9UJ79; Q9UPN9" "Ectoderm differentiation" "Downregulation of SMAD2/3:SMAD4 transcriptional activity; Germ layer formation at gastrulation" "3" "1" "0.993" "1.014" "1.043" "1.259" "1.084" "1.065" "1.034" "1.073" "1.072" "685.1" "680.2" "694.6" "714.6" "862.7" "742.9" "729.7" "708.6" "735.1" "734.1" "" "" "" "" "" "" "" "" "" "" "641.9" "562.8" "644.8" "552.4" "735.4" "709.8" "666.7" "629.1" "735.1" "706.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3251544276452061183" "False" "High" "IsMasterProtein" "P26368" "Splicing factor U2AF 65 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF2 PE=1 SV=4" "0.000" "False" "31.135" "23" "8" "12" "8" "475" "53.5" "9.09" "39.23" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "11338" "ENSG00000063244" "U2AF2" "hsa:11338; P26368; Q96HC5" "mRNA processing; Warburg effect modulated by deubiquitinating enzymes and their substrates" "mRNA Splicing - Major Pathway; Protein hydroxylation; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "7" "0" "1.101" "1.234" "1.178" "1.117" "1.074" "1.586" "1.597" "1.601" "1.273" "1003.4" "1104.9" "1238.4" "1181.6" "1120.4" "1077.2" "1591.5" "1602.5" "1606.9" "1277.1" "" "" "" "" "" "" "" "" "" "" "940.2" "914.3" "1149.7" "913.4" "955.0" "1029.1" "1454.2" "1422.9" "1606.9" "1229.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3377056009907556172" "False" "High" "IsMasterProtein" "O14745" "Na(+)/H(+) exchange regulatory cofactor NHE-RF1 OS=Homo sapiens OX=9606 GN=NHERF1 PE=1 SV=4" "0.000" "False" "31.122" "30" "9" "15" "9" "358" "38.8" "5.77" "51.54" "9" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;transporter activity;cytoskeletal activity;other molecular function" "Pf00595, Pf09007" "9368" "ENSG00000109062" "NHERF1" "B3KY21; hsa:9368; O14745; O43552; Q86WQ5" "TAR syndrome" "" "1" "0" "1.053" "0.924" "0.978" "0.996" "1.081" "1.070" "1.127" "1.014" "0.983" "1912.9" "2014.5" "1768.0" "1871.0" "1905.0" "2068.2" "2047.1" "2156.2" "1940.5" "1880.2" "" "" "" "" "" "" "" "" "" "" "1792.4" "1667.0" "1641.3" "1446.4" "1623.8" "1976.0" "1870.5" "1914.5" "1940.5" "1810.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2333660704476735765" "False" "High" "IsMasterProtein" "O15397" "Importin-8 OS=Homo sapiens OX=9606 GN=IPO8 PE=1 SV=2" "0.000" "False" "31.087" "10" "9" "15" "9" "1037" "119.9" "5.16" "48.23" "9" "transport;signal transduction" "cytosol;nucleus" "other molecular function" "Pf03810, Pf08506" "10526" "ENSG00000133704" "IPO8" "B7Z7M3; hsa:10526; O15397" "Autophagy in pancreatic ductal adenocarcinoma" "Transcriptional regulation by small RNAs" "2" "0" "1.068" "1.033" "1.242" "1.084" "1.084" "1.056" "1.028" "1.049" "1.047" "1095.7" "1170.0" "1131.7" "1360.5" "1188.1" "1187.8" "1156.5" "1126.1" "1149.0" "1146.7" "" "" "" "" "" "" "" "" "" "" "1026.6" "968.1" "1050.7" "1051.8" "1012.7" "1134.9" "1056.7" "999.9" "1149.0" "1104.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-867231523467416798" "False" "High" "IsMasterProtein" "Q6K0P9" "Pyrin and HIN domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PYHIN1 PE=1 SV=1" "0.000" "False" "30.989" "23" "10" "17" "8" "492" "55.0" "9.80" "54.46" "10" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02758, Pf02760" "149628" "ENSG00000163564" "PYHIN1" "hsa:149628; Q5T3W6; Q6K0P6; Q6K0P7; Q6K0P8; Q6K0P9; Q8WW65" "" "" "0" "0" "0.976" "1.144" "1.045" "1.117" "1.115" "1.060" "1.076" "1.089" "1.135" "353.3" "344.7" "404.2" "369.0" "394.7" "394.0" "374.5" "380.1" "384.7" "400.9" "" "" "" "" "" "" "" "" "" "" "331.0" "285.3" "375.2" "285.3" "336.4" "376.4" "342.2" "337.5" "384.7" "386.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7953357218888963531" "False" "High" "IsMasterProtein" "Q3KQU3" "MAP7 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MAP7D1 PE=1 SV=1" "0.000" "False" "30.981" "12" "10" "13" "10" "841" "92.8" "10.11" "44.96" "10" "cell organization and biogenesis" "cytoskeleton;other cell component" "" "Pf05672" "55700" "ENSG00000116871" "MAP7D1" "D3DPS4; hsa:55700; Q3KQU3; Q7L8J5; Q8N905; Q8TAK0; Q9HBQ2; Q9NW29; Q9ULN3" "" "" "0" "0" "1.045" "0.992" "0.962" "1.001" "0.974" "0.966" "0.900" "0.891" "1.003" "952.6" "995.1" "945.0" "916.1" "953.6" "927.4" "920.5" "857.3" "848.6" "955.0" "" "" "" "" "" "" "" "" "" "" "892.6" "823.4" "877.3" "708.2" "812.8" "886.1" "841.1" "761.2" "848.6" "919.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1205660111365886564" "False" "High" "IsMasterProtein" "Q92599" "Septin-8 OS=Homo sapiens OX=9606 GN=SEPTIN8 PE=1 SV=4" "0.000" "False" "30.957" "21" "8" "15" "4" "483" "55.7" "6.28" "39.19" "8" "cell cycle OR cell proliferation;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "23176" "ENSG00000164402" "SEPTIN8" "A6NC65; A6NKP6; F6W7K9; hsa:23176; Q8IX36; Q8IX37; Q92599; Q9BVB3" "22q11.2 copy number variation syndrome" "" "1" "0" "1.006" "1.053" "1.052" "1.040" "1.061" "1.008" "0.969" "0.954" "1.020" "212.5" "213.8" "223.8" "223.6" "221.1" "225.6" "214.2" "205.9" "202.7" "216.8" "" "" "" "" "" "" "" "" "" "" "199.1" "176.9" "207.8" "172.9" "188.4" "215.5" "195.7" "182.8" "202.7" "208.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8472410284542291541" "False" "High" "IsMasterProtein" "P61289" "Proteasome activator complex subunit 3 OS=Homo sapiens OX=9606 GN=PSME3 PE=1 SV=1" "0.000" "False" "30.920" "36" "9" "19" "9" "254" "29.5" "5.95" "56.14" "9" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02251, Pf02252" "10197" "ENSG00000131467" "PSME3" "A8K9A3; hsa:10197; O35563; P61289; P97373; Q12920; Q13172; Q9BQD9" "Proteasome degradation" "Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs; ER-Phagosome pathway; Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "60" "0" "0.994" "1.015" "1.004" "1.008" "1.001" "0.954" "0.950" "0.932" "0.956" "1855.5" "1844.5" "1882.5" "1863.2" "1870.4" "1857.3" "1769.5" "1763.1" "1729.1" "1773.8" "" "" "" "" "" "" "" "" "" "" "1738.6" "1526.3" "1747.6" "1440.4" "1594.3" "1774.4" "1616.9" "1565.5" "1729.1" "1708.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7968684939462891772" "False" "High" "IsMasterProtein" "O14974" "Protein phosphatase 1 regulatory subunit 12A OS=Homo sapiens OX=9606 GN=PPP1R12A PE=1 SV=1" "0.000" "False" "30.887" "10" "11" "12" "11" "1030" "115.2" "5.40" "39.59" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf15898" "4659" "ENSG00000058272" "PPP1R12A" "B4DZ09; F8VWB4; hsa:4659; O14974; Q2NKL4; Q569H0; Q86WU3; Q8NFR6; Q9BYH0" "Focal adhesion; Hippo-Merlin signaling dysregulation; Regulation of actin cytoskeleton" "Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "8" "0" "0.927" "0.969" "0.961" "1.123" "1.084" "1.196" "1.282" "1.239" "1.097" "1077.7" "998.6" "1044.7" "1036.1" "1210.3" "1167.9" "1289.2" "1381.1" "1335.6" "1182.3" "" "" "" "" "" "" "" "" "" "" "1009.8" "826.3" "969.8" "801.0" "1031.7" "1115.8" "1178.0" "1226.3" "1335.6" "1138.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2447510198658431817" "False" "High" "IsMasterProtein" "Q9H910" "Jupiter microtubule associated homolog 2 OS=Homo sapiens OX=9606 GN=JPT2 PE=1 SV=1" "0.000" "False" "30.885" "66" "9" "18" "9" "190" "20.1" "9.26" "50.18" "9" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf17054" "90861" "ENSG00000206053" "JPT2" "B1AJY2; B4DLH4; hsa:90861; Q6EIC7; Q9H910" "" "" "0" "0" "1.013" "0.997" "0.986" "1.019" "0.961" "0.955" "0.971" "0.942" "1.023" "1920.0" "1945.6" "1914.0" "1893.7" "1956.1" "1844.5" "1833.1" "1864.3" "1808.4" "1963.2" "" "" "" "" "" "" "" "" "" "" "1799.0" "1610.0" "1776.9" "1463.9" "1667.3" "1762.2" "1675.0" "1655.3" "1808.4" "1890.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4520162396586865811" "False" "High" "IsMasterProtein" "P51148" "Ras-related protein Rab-5C OS=Homo sapiens OX=9606 GN=RAB5C PE=1 SV=2" "0.000" "False" "30.877" "41" "7" "10" "4" "216" "23.5" "8.41" "39.86" "7" "transport" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5878" "ENSG00000108774" "RAB5C" "F8W1H5; hsa:5878; P51148; Q6FH55; Q9P0Y5" "Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Vasopressin-regulated water reabsorption" "RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; TBC/RABGAPs" "10" "0" "1.034" "0.960" "1.076" "1.011" "0.980" "1.024" "1.030" "0.986" "0.955" "698.7" "722.6" "671.0" "751.5" "706.3" "684.5" "715.6" "719.3" "688.8" "666.9" "" "" "" "" "" "" "" "" "" "" "654.6" "598.0" "622.9" "581.0" "602.1" "654.0" "653.9" "638.7" "688.8" "642.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7890686096526149286" "False" "High" "IsMasterProtein" "Q13347" "Eukaryotic translation initiation factor 3 subunit I OS=Homo sapiens OX=9606 GN=EIF3I PE=1 SV=1" "0.000" "False" "30.868" "30" "8" "12" "8" "325" "36.5" "5.64" "36.62" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00400, Pf12894" "8668" "ENSG00000084623" "EIF3I" "hsa:8668; Q13347" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "0.977" "1.039" "0.916" "0.948" "0.962" "1.014" "1.076" "1.103" "1.031" "755.2" "737.7" "784.8" "692.1" "715.9" "726.7" "765.7" "812.6" "832.7" "778.2" "" "" "" "" "" "" "" "" "" "" "707.6" "610.4" "728.6" "535.0" "610.2" "694.3" "699.7" "721.5" "832.7" "749.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3099345167640791747" "False" "High" "IsMasterProtein" "Q00796" "Sorbitol dehydrogenase OS=Homo sapiens OX=9606 GN=SORD PE=1 SV=4" "0.000" "False" "30.858" "26" "9" "16" "9" "357" "38.3" "7.97" "53.60" "9" "other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion" "other molecular function" "Pf00107, Pf08240" "6652" "ENSG00000140263" "SORD" "B2R655; B7Z3A6; hsa:6652; J3JZZ5; Q00796; Q16682; Q9UMD6" "Disorders of fructose metabolism; Polyol pathway" "Formation of xylulose-5-phosphate; Fructose biosynthesis" "4" "0" "0.962" "1.009" "1.007" "0.963" "0.968" "0.957" "0.961" "1.023" "0.977" "1118.0" "1075.6" "1128.4" "1125.8" "1077.2" "1081.8" "1069.4" "1074.4" "1143.7" "1091.8" "" "" "" "" "" "" "" "" "" "" "1047.6" "890.1" "1047.6" "870.3" "918.2" "1033.5" "977.2" "954.0" "1143.7" "1051.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4890762250346228692" "False" "High" "IsMasterProtein" "P35250" "Replication factor C subunit 2 OS=Homo sapiens OX=9606 GN=RFC2 PE=1 SV=3" "0.000" "False" "30.833" "31" "9" "16" "9" "354" "39.1" "6.44" "46.52" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5982" "ENSG00000049541" "RFC2" "B5BU07; D3DXG3; hsa:5982; P32846; P35250; Q9BU93" "DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Homologous Recombination (HRR); HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Activation of ATR in response to replication stress; Termination of translesion DNA synthesis; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "27" "0" "1.025" "1.033" "1.053" "1.019" "1.029" "0.988" "0.979" "1.051" "1.031" "1690.9" "1733.4" "1746.6" "1781.1" "1722.7" "1740.2" "1671.4" "1655.4" "1776.4" "1742.5" "" "" "" "" "" "" "" "" "" "" "1584.3" "1434.3" "1621.5" "1376.9" "1468.4" "1662.6" "1527.2" "1469.8" "1776.4" "1677.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1728322554936911435" "False" "High" "IsMasterProtein" "Q14978" "Nucleolar and coiled-body phosphoprotein 1 OS=Homo sapiens OX=9606 GN=NOLC1 PE=1 SV=2" "0.000" "False" "30.751" "13" "11" "18" "11" "699" "73.6" "9.47" "43.92" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05022" "9221" "ENSG00000166197" "NOLC1" "hsa:9221; Q14978; Q15030; Q5VV70; Q9BUV3" "" "" "0" "0" "1.012" "1.004" "0.975" "1.008" "1.043" "1.286" "1.340" "1.249" "1.115" "1841.5" "1863.8" "1849.4" "1795.2" "1857.1" "1920.4" "2369.0" "2467.2" "2300.3" "2052.4" "" "" "" "" "" "" "" "" "" "" "1725.5" "1542.3" "1717.0" "1387.7" "1583.0" "1834.8" "2164.7" "2190.6" "2300.3" "1976.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6821815504623325969" "False" "High" "IsMasterProtein" "Q9UMX0" "Ubiquilin-1 OS=Homo sapiens OX=9606 GN=UBQLN1 PE=1 SV=2" "0.000" "False" "30.725" "20" "8" "11" "4" "589" "62.5" "5.11" "42.63" "8" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "29979" "ENSG00000135018" "UBQLN1" "A0A024R284; hsa:29979; Q5T6J5; Q5T6J9; Q8IXS9; Q8N2Q3; Q9H0T8; Q9H3R4; Q9HAZ5; Q9UMX0" "" "Cargo recognition for clathrin-mediated endocytosis" "1" "4" "1.128" "1.051" "1.018" "1.099" "1.146" "1.021" "1.059" "1.140" "1.055" "664.8" "750.1" "698.7" "676.9" "730.9" "762.0" "678.5" "703.9" "757.9" "701.3" "" "" "" "" "" "" "" "" "" "" "622.9" "620.7" "648.6" "523.3" "623.0" "728.0" "620.0" "625.0" "757.9" "675.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1084161266970488512" "False" "High" "IsMasterProtein" "Q04206" "Transcription factor p65 OS=Homo sapiens OX=9606 GN=RELA PE=1 SV=2" "0.000" "False" "30.707" "21" "10" "17" "10" "551" "60.2" "5.68" "61.71" "10" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "5970" "ENSG00000173039" "RELA" "hsa:5970; Q04206; Q6GTV1; Q6SLK1" "Androgen receptor signaling pathway; Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Selenium metabolism and selenoproteins; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; ApoE and miR-146 in inflammation and atherosclerosis; Chemokine signaling pathway; IL-4 signaling pathway; NO/cGMP/PKG mediated neuroprotection; Fibrin complement receptor 3 signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Nonalcoholic fatty liver disease; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; CAMKK2 pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; Opioid receptor pathways; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; Osteoarthritic chondrocyte hypertrophy; 15q11q13 copy number variation; T-cell receptor signaling pathway; Toll-like receptor signaling pathway" "Senescence-Associated Secretory Phenotype (SASP); FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Dectin-1 mediated noncanonical NF-kB signaling; Transcriptional regulation of white adipocyte differentiation; Transcriptional Regulation by VENTX; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; Regulation of NFE2L2 gene expression; CD209 (DC-SIGN) signaling; Interleukin-1 processing; CLEC7A/inflammasome pathway; Regulated proteolysis of p75NTR; SUMOylation of immune response proteins; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "101" "0" "1.018" "1.022" "1.109" "1.043" "1.056" "1.066" "1.035" "1.026" "1.040" "1120.3" "1140.2" "1144.4" "1241.9" "1168.8" "1182.8" "1194.5" "1159.7" "1149.5" "1164.8" "" "" "" "" "" "" "" "" "" "" "1049.7" "943.5" "1062.5" "960.1" "996.2" "1130.0" "1091.5" "1029.7" "1149.5" "1121.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6456635449604072928" "False" "High" "IsMasterProtein" "P30419" "Glycylpeptide N-tetradecanoyltransferase 1 OS=Homo sapiens OX=9606 GN=NMT1 PE=1 SV=2" "0.000" "False" "30.681" "22" "9" "16" "9" "496" "56.8" "7.80" "44.51" "9" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf01233, Pf02799" "4836" "ENSG00000136448" "NMT1" "A8K7C1; hsa:4836; P30419; Q9UE09" "" "Inactivation, recovery and regulation of the phototransduction cascade; Late Phase of HIV Life Cycle; Activation, myristolyation of BID and translocation to mitochondria" "3" "0" "1.005" "1.034" "1.052" "1.015" "0.968" "0.991" "1.004" "1.003" "0.998" "1763.7" "1773.4" "1823.6" "1855.5" "1789.9" "1707.6" "1748.3" "1770.3" "1768.9" "1761.0" "" "" "" "" "" "" "" "" "" "" "1652.6" "1467.5" "1692.9" "1434.4" "1525.7" "1631.5" "1597.4" "1571.9" "1768.9" "1695.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9010932242184779008" "False" "High" "IsMasterProtein" "P10644" "cAMP-dependent protein kinase type I-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR1A PE=1 SV=1" "0.000" "False" "30.677" "25" "10" "16" "7" "381" "43.0" "5.35" "46.74" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5573" "ENSG00000108946" "PRKAR1A" "hsa:5573; K7ER48; P10644; Q567S7" "Mesodermal commitment pathway; Myometrial relaxation and contraction pathways; Mesodermal commitment pathway; G protein signaling pathways; Cannabinoid receptor signaling; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Cardiomyocyte signaling pathways converging on titin; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase" "27" "3" "0.972" "0.981" "0.959" "0.992" "1.005" "0.928" "0.923" "0.965" "1.006" "1875.5" "1822.8" "1839.9" "1798.3" "1861.1" "1884.7" "1740.8" "1730.5" "1809.5" "1886.6" "" "" "" "" "" "" "" "" "" "" "1757.3" "1508.3" "1708.1" "1390.2" "1586.3" "1800.6" "1590.6" "1536.5" "1809.5" "1816.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6904106809310251565" "False" "High" "IsMasterProtein" "Q9Y6X9" "ATPase MORC2 OS=Homo sapiens OX=9606 GN=MORC2 PE=1 SV=2" "0.000" "False" "30.633" "11" "13" "15" "13" "1032" "117.8" "8.38" "44.11" "13" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07496, Pf13589, Pf17942" "22880" "ENSG00000133422" "MORC2" "B2RNB1; hsa:22880; Q9UF28; Q9Y6V2; Q9Y6X9" "" "Fatty acyl-CoA biosynthesis" "1" "0" "1.002" "0.989" "1.075" "1.010" "1.024" "1.055" "1.062" "1.030" "1.031" "1777.8" "1780.5" "1758.2" "1911.6" "1796.0" "1821.1" "1876.2" "1887.2" "1831.8" "1832.7" "" "" "" "" "" "" "" "" "" "" "1665.8" "1473.3" "1632.3" "1477.8" "1530.9" "1739.9" "1714.4" "1675.7" "1831.8" "1764.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1694253408134936187" "False" "High" "IsMasterProtein" "P50452" "Serpin B8 OS=Homo sapiens OX=9606 GN=SERPINB8 PE=1 SV=2" "0.000" "False" "30.625" "26" "10" "14" "9" "374" "42.7" "5.57" "42.98" "10" "cell adhesion;other biological processes" "non-structural extracellular;cytosol;other cell component" "enzyme regulator activity" "Pf00079" "5271" "ENSG00000166401" "SERPINB8" "B4DTW2; P50452; Q7Z2V6; Q8N178" "" "Dissolution of Fibrin Clot" "1" "0" "0.959" "0.981" "1.023" "0.945" "0.902" "0.948" "0.961" "0.979" "0.947" "1011.3" "969.9" "991.7" "1034.3" "955.3" "912.7" "958.6" "971.8" "989.6" "957.8" "" "" "" "" "" "" "" "" "" "" "947.6" "802.5" "920.7" "799.6" "814.2" "872.0" "875.9" "862.9" "989.6" "922.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6271910638518906992" "False" "High" "IsMasterProtein" "Q92552" "Small ribosomal subunit protein mS27 OS=Homo sapiens OX=9606 GN=MRPS27 PE=1 SV=3" "0.000" "False" "30.617" "27" "10" "14" "10" "414" "47.6" "6.18" "47.91" "10" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf10037" "23107" "ENSG00000113048" "MRPS27" "B4DRT2; hsa:23107; Q6P1S1; Q92552" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.998" "1.066" "0.996" "1.056" "1.035" "1.018" "0.987" "1.027" "1.052" "1640.8" "1636.8" "1748.5" "1634.7" "1732.7" "1698.2" "1670.7" "1619.4" "1684.5" "1725.6" "" "" "" "" "" "" "" "" "" "" "1537.4" "1354.4" "1623.3" "1263.7" "1476.9" "1622.5" "1526.6" "1437.8" "1684.5" "1661.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "961314597478386434" "False" "High" "IsMasterProtein" "P57740" "Nuclear pore complex protein Nup107 OS=Homo sapiens OX=9606 GN=NUP107 PE=1 SV=1" "0.000" "False" "30.595" "11" "10" "12" "10" "925" "106.3" "5.43" "29.57" "10" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04121" "57122" "ENSG00000111581" "NUP107" "B4DZ67; hsa:57122; P57740; Q6PJE1" "Gastric cancer network 1; Primary ovarian insufficiency" "Separation of Sister Chromatids; SUMOylation of ubiquitinylation proteins; HCMV Late Events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "37" "0" "1.018" "1.037" "1.016" "0.978" "1.057" "1.023" "1.007" "1.029" "1.065" "900.4" "916.6" "933.8" "915.0" "880.4" "951.5" "920.8" "906.3" "926.7" "958.6" "" "" "" "" "" "" "" "" "" "" "843.6" "758.5" "866.9" "707.3" "750.4" "909.1" "841.3" "804.7" "926.7" "923.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5860856138791644160" "False" "High" "IsMasterProtein" "Q9Y5A9" "YTH domain-containing family protein 2 OS=Homo sapiens OX=9606 GN=YTHDF2 PE=1 SV=2" "0.000" "False" "30.583" "15" "9" "14" "4" "579" "62.3" "8.79" "42.98" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04146" "51441" "ENSG00000198492" "YTHDF2" "A6NKG4; A8K966; B4E1G7; D3DPM8; hsa:51441; Q5VSZ9; Q8TDH0; Q9BUJ5; Q9Y5A9" "" "" "0" "4" "1.077" "1.033" "1.015" "1.054" "1.095" "1.017" "1.080" "1.097" "1.069" "2406.6" "2591.7" "2484.9" "2443.5" "2535.6" "2635.6" "2446.5" "2599.4" "2639.8" "2572.9" "" "" "" "" "" "" "" "" "" "" "2255.0" "2144.6" "2306.9" "1888.9" "2161.3" "2518.1" "2235.4" "2308.0" "2639.8" "2477.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2843591473366045892" "False" "High" "IsMasterProtein" "P62136" "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CA PE=1 SV=1" "0.000" "False" "30.555" "31" "9" "13" "2" "330" "37.5" "6.33" "40.60" "9" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5499" "ENSG00000172531" "PPP1CA" "A6NNR3; B2R908; hsa:5499; P08129; P20653; P22802; P62136; Q07161" "Sphingolipid pathway; Nicotine effect on dopaminergic neurons; Common pathways underlying drug addiction; Focal adhesion; VEGFA-VEGFR2 signaling; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Netrin-UNC5B signaling pathway; Neuroinflammation and glutamatergic signaling; HDAC6 interactions in the central nervous system" "Triglyceride catabolism; Circadian Clock; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins; DARPP-32 events" "15" "6" "1.052" "1.041" "1.101" "1.041" "1.101" "1.094" "1.096" "1.087" "1.041" "1232.9" "1297.1" "1283.1" "1357.1" "1283.4" "1357.1" "1348.9" "1351.3" "1340.0" "1283.3" "" "" "" "" "" "" "" "" "" "" "1155.2" "1073.3" "1191.2" "1049.1" "1094.0" "1296.6" "1232.6" "1199.8" "1340.0" "1235.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9172177916429743793" "False" "High" "IsMasterProtein" "Q99816" "Tumor susceptibility gene 101 protein OS=Homo sapiens OX=9606 GN=TSG101 PE=1 SV=2" "0.000" "False" "30.509" "27" "9" "10" "9" "390" "43.9" "6.46" "35.04" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf05743, Pf09454" "7251" "ENSG00000074319" "TSG101" "hsa:7251; Q99816; Q9BUM5" "Ebola virus infection in host; 7q11.23 copy number variation syndrome" "HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy" "7" "0" "0.951" "0.969" "0.990" "0.999" "1.030" "0.966" "0.976" "0.959" "0.998" "1239.4" "1178.4" "1201.5" "1227.4" "1238.3" "1276.6" "1197.2" "1209.7" "1188.9" "1237.1" "" "" "" "" "" "" "" "" "" "" "1161.3" "975.1" "1115.4" "948.8" "1055.5" "1219.6" "1094.0" "1074.1" "1188.9" "1191.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-296072814185556824" "False" "High" "IsMasterProtein" "Q9BUI4" "DNA-directed RNA polymerase III subunit RPC3 OS=Homo sapiens OX=9606 GN=POLR3C PE=1 SV=1" "0.000" "False" "30.501" "21" "10" "12" "10" "534" "60.6" "7.31" "32.72" "10" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05645, Pf08221, Pf20912" "10623" "ENSG00000186141" "POLR3C" "hsa:10623; O15317; Q9BUI4; Q9Y3R6" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; TAR syndrome" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "1.033" "1.003" "1.063" "1.043" "1.030" "0.988" "1.029" "1.031" "1.066" "1650.1" "1704.0" "1655.4" "1754.2" "1721.0" "1699.2" "1631.0" "1697.9" "1701.1" "1759.6" "" "" "" "" "" "" "" "" "" "" "1546.1" "1410.1" "1536.8" "1356.1" "1467.0" "1623.5" "1490.3" "1507.6" "1701.1" "1694.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1629883586476679929" "False" "High" "IsMasterProtein" "Q9BT78" "COP9 signalosome complex subunit 4 OS=Homo sapiens OX=9606 GN=COPS4 PE=1 SV=1" "0.000" "False" "30.446" "24" "8" "17" "8" "406" "46.2" "5.83" "56.07" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01399, Pf18420" "51138" "ENSG00000138663" "COPS4" "B3KN88; B3KST5; hsa:51138; Q561W7; Q9BT78; Q9NW31; Q9Y677" "Ciliary landscape" "Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER; Cargo recognition for clathrin-mediated endocytosis; RHOBTB1 GTPase cycle" "6" "0" "0.964" "0.947" "0.982" "0.947" "0.951" "0.957" "0.965" "0.952" "0.962" "2455.2" "2366.2" "2324.9" "2411.1" "2324.2" "2335.0" "2348.8" "2368.4" "2336.7" "2362.8" "" "" "" "" "" "" "" "" "" "" "2300.5" "1958.0" "2158.4" "1863.9" "1981.1" "2230.9" "2146.2" "2102.9" "2336.7" "2275.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5314781854584049203" "False" "High" "IsMasterProtein" "O75436" "Vacuolar protein sorting-associated protein 26A OS=Homo sapiens OX=9606 GN=VPS26A PE=1 SV=2" "0.000" "False" "30.442" "35" "10" "12" "9" "327" "38.1" "6.57" "37.22" "10" "transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf03643" "9559" "ENSG00000122958" "VPS26A" "A8MZ56; B2RDD3; hsa:9559; O75436; Q8TBH4; Q9H982" "" "WNT ligand biogenesis and trafficking" "1" "1" "0.967" "1.021" "1.005" "1.004" "1.006" "0.992" "0.978" "1.003" "1.003" "1400.4" "1353.6" "1429.8" "1407.9" "1406.3" "1408.8" "1389.6" "1369.5" "1404.5" "1404.3" "" "" "" "" "" "" "" "" "" "" "1312.2" "1120.1" "1327.4" "1088.4" "1198.7" "1346.0" "1269.7" "1216.0" "1404.5" "1352.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8833094404749326966" "False" "High" "IsMasterProtein" "Q9Y285" "Phenylalanine--tRNA ligase alpha subunit OS=Homo sapiens OX=9606 GN=FARSA PE=1 SV=3" "0.000" "False" "30.439" "21" "10" "15" "10" "508" "57.5" "7.80" "43.80" "10" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01409, Pf18552, Pf18553, Pf18554" "2193" "ENSG00000179115" "FARSA" "B4E363; hsa:2193; Q9NSD8; Q9Y285; Q9Y4W8" "" "Cytosolic tRNA aminoacylation" "1" "0" "0.986" "1.023" "1.056" "0.945" "1.010" "0.964" "0.982" "0.970" "1.011" "945.4" "931.7" "967.5" "998.6" "893.3" "954.5" "911.3" "928.1" "917.0" "956.0" "" "" "" "" "" "" "" "" "" "" "885.8" "771.0" "898.2" "772.0" "761.5" "911.9" "832.7" "824.0" "917.0" "920.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3824226989303919527" "False" "High" "IsMasterProtein" "Q68EM7" "Rho GTPase-activating protein 17 OS=Homo sapiens OX=9606 GN=ARHGAP17 PE=1 SV=1" "0.000" "False" "30.423" "11" "10" "12" "10" "881" "95.4" "7.62" "40.55" "10" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00620, Pf03114" "55114" "ENSG00000140750; ENSG00000288353" "ARHGAP17" "A8K6M6; hsa:55114; Q68EM7; Q6ZUS4; Q7Z2F2; Q8NDG2; Q96KS2; Q96KS3; Q96SS8; Q9BVF6; Q9H8U5; Q9NW54" "" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle" "6" "0" "0.947" "0.969" "0.926" "0.958" "0.953" "0.926" "0.937" "0.952" "0.964" "2499.2" "2367.5" "2421.2" "2313.7" "2393.3" "2382.0" "2315.4" "2342.1" "2379.9" "2410.2" "" "" "" "" "" "" "" "" "" "" "2341.8" "1959.1" "2247.8" "1788.6" "2040.0" "2275.7" "2115.6" "2079.5" "2379.9" "2320.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5136159273712408888" "False" "High" "IsMasterProtein" "P38919" "Eukaryotic initiation factor 4A-III OS=Homo sapiens OX=9606 GN=EIF4A3 PE=1 SV=4" "0.000" "False" "30.417" "21" "9" "18" "8" "411" "46.8" "6.73" "54.52" "9" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "9775" "ENSG00000141543; ENSG00000291508" "EIF4A3" "hsa:9775; P38919; Q15033; Q6IBQ2; Q96A18" "TAR syndrome" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "11" "0" "0.976" "0.999" "1.092" "1.076" "0.996" "1.092" "1.093" "1.052" "0.998" "1303.4" "1272.7" "1301.5" "1423.7" "1402.0" "1298.7" "1423.0" "1424.3" "1371.0" "1301.3" "" "" "" "" "" "" "" "" "" "" "1221.3" "1053.2" "1208.3" "1100.6" "1195.0" "1240.8" "1300.2" "1264.7" "1371.0" "1253.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2527179580342077355" "False" "High" "IsMasterProtein" "Q9NUQ9" "CYFIP-related Rac1 interactor B OS=Homo sapiens OX=9606 GN=CYRIB PE=1 SV=1" "0.000" "False" "30.405" "30" "8" "13" "7" "324" "36.7" "6.06" "42.52" "8" "cell organization and biogenesis;other biological processes" "non-structural extracellular;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf07159" "51571" "ENSG00000153310" "CYRIB" "hsa:51571; Q96AZ5; Q9NUQ9; Q9NW21; Q9NZE7" "" "Platelet degranulation" "1" "0" "1.025" "1.014" "1.043" "1.021" "1.035" "1.067" "1.011" "1.034" "0.998" "1221.0" "1251.6" "1238.1" "1273.2" "1246.6" "1263.9" "1303.2" "1234.7" "1262.3" "1218.1" "" "" "" "" "" "" "" "" "" "" "1144.0" "1035.6" "1149.4" "984.3" "1062.6" "1207.6" "1190.8" "1096.3" "1262.3" "1172.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9106014466644302785" "False" "High" "IsMasterProtein" "Q9Y5Q8" "General transcription factor 3C polypeptide 5 OS=Homo sapiens OX=9606 GN=GTF3C5 PE=1 SV=2" "0.000" "False" "30.347" "21" "10" "12" "10" "519" "59.5" "6.90" "34.29" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09734, Pf17682" "9328" "ENSG00000148308" "GTF3C5" "A6NI44; A6NJB9; hsa:9328; Q5T7U2; Q5T7U3; Q8N2U7; Q8N857; Q96GD9; Q9H4P2; Q9Y5Q8" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "3" "0" "1.030" "1.029" "1.011" "1.047" "1.032" "0.959" "0.933" "1.025" "1.049" "1141.8" "1175.9" "1175.3" "1153.9" "1195.8" "1177.9" "1095.0" "1065.7" "1170.9" "1198.2" "" "" "" "" "" "" "" "" "" "" "1069.9" "973.0" "1091.1" "892.0" "1019.3" "1125.4" "1000.5" "946.2" "1170.9" "1153.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7380698507310522757" "False" "High" "IsMasterProtein" "P41227" "N-alpha-acetyltransferase 10 OS=Homo sapiens OX=9606 GN=NAA10 PE=1 SV=1" "0.000" "False" "30.344" "41" "10" "14" "10" "235" "26.4" "5.64" "39.37" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "8260" "ENSG00000102030" "NAA10" "A6NM98; hsa:8260; P41227" "" "" "0" "0" "0.953" "0.985" "0.862" "0.941" "1.027" "0.852" "0.949" "0.887" "0.963" "1425.3" "1358.5" "1404.3" "1228.7" "1341.9" "1463.1" "1214.6" "1352.1" "1264.1" "1372.3" "" "" "" "" "" "" "" "" "" "" "1335.5" "1124.1" "1303.7" "949.8" "1143.8" "1397.9" "1109.9" "1200.5" "1264.1" "1321.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2840679928359396214" "False" "High" "IsMasterProtein" "Q6P1N0" "Coiled-coil and C2 domain-containing protein 1A OS=Homo sapiens OX=9606 GN=CC2D1A PE=1 SV=1" "0.000" "False" "30.293" "9" "10" "12" "10" "951" "104.0" "8.09" "36.55" "10" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf00168, Pf21528" "54862" "ENSG00000132024; ENSG00000288293" "CC2D1A" "hsa:54862; Q6P1N0; Q7Z435; Q86XV0; Q8NF89; Q9H603; Q9NXI1" "Sudden infant death syndrome (SIDS) susceptibility pathways" "" "1" "0" "1.076" "0.982" "1.122" "1.136" "1.056" "1.075" "0.963" "0.994" "1.034" "889.1" "956.8" "873.5" "997.6" "1010.5" "938.7" "956.3" "855.9" "884.1" "919.1" "" "" "" "" "" "" "" "" "" "" "833.1" "791.7" "811.0" "771.2" "861.3" "896.9" "873.8" "760.0" "884.1" "884.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7643769137675685694" "False" "High" "IsMasterProtein" "P82933" "Small ribosomal subunit protein uS9m OS=Homo sapiens OX=9606 GN=MRPS9 PE=1 SV=2" "0.000" "False" "30.288" "29" "11" "12" "11" "396" "45.8" "9.51" "39.21" "11" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00380" "64965" "ENSG00000135972" "MRPS9" "hsa:64965; P82933; Q6PG40" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.037" "0.981" "1.006" "1.013" "1.057" "1.001" "0.925" "0.982" "1.022" "962.7" "998.4" "944.6" "968.1" "975.2" "1017.8" "963.7" "890.1" "945.1" "983.6" "" "" "" "" "" "" "" "" "" "" "902.0" "826.2" "877.0" "748.4" "831.2" "972.4" "880.6" "790.3" "945.1" "947.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1612491288449717862" "False" "High" "IsMasterProtein" "Q13155" "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 OS=Homo sapiens OX=9606 GN=AIMP2 PE=1 SV=2" "0.000" "False" "30.284" "30" "10" "22" "10" "320" "35.3" "8.22" "58.50" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00043, Pf16780, Pf18569" "7965" "ENSG00000106305" "AIMP2" "F8W950; hsa:7965; Q13155; Q75MR1; Q96CZ5; Q9P1L2" "Osteoclast signaling; Transcriptional activation by NRF2 in response to phytochemicals; NRF2-ARE regulation" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "5" "0" "1.019" "1.015" "0.992" "0.989" "0.997" "0.940" "0.958" "1.003" "0.995" "2986.7" "3042.2" "3032.8" "2962.3" "2954.5" "2978.8" "2807.0" "2860.5" "2994.4" "2973.0" "" "" "" "" "" "" "" "" "" "" "2798.5" "2517.4" "2815.6" "2290.0" "2518.3" "2846.0" "2564.9" "2539.9" "2994.4" "2862.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4060364465058462245" "False" "High" "IsMasterProtein" "Q15435" "Protein phosphatase 1 regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PPP1R7 PE=1 SV=1" "0.000" "False" "30.255" "28" "10" "18" "10" "360" "41.5" "4.91" "55.34" "10" "other biological processes" "other cell component" "enzyme regulator activity" "Pf12799, Pf14580" "5510" "ENSG00000115685" "PPP1R7" "B4DFD4; B5MCY6; hsa:5510; Q15435; Q9UQE5; Q9UQE6; Q9Y6K4" "2q37 copy number variation syndrome" "" "1" "0" "1.017" "1.031" "0.984" "1.019" "1.019" "0.949" "1.027" "1.019" "1.046" "1486.6" "1511.7" "1532.0" "1462.7" "1514.6" "1515.0" "1410.9" "1527.1" "1515.4" "1554.3" "" "" "" "" "" "" "" "" "" "" "1392.9" "1250.9" "1422.2" "1130.7" "1291.0" "1447.4" "1289.2" "1355.9" "1515.4" "1496.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3363379489977265255" "False" "High" "IsMasterProtein" "P00441" "Superoxide dismutase [Cu-Zn] OS=Homo sapiens OX=9606 GN=SOD1 PE=1 SV=2" "0.000" "False" "30.249" "44" "8" "20" "8" "154" "15.9" "6.13" "56.57" "8" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00080" "6647" "ENSG00000142168" "SOD1" "A6NHJ0; D3DSE4; P00441; Q16669; Q16711; Q16838; Q16839; Q16840; Q6NR85" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; AGE/RAGE pathway; Dopamine metabolism; Amyotrophic lateral sclerosis (ALS); Trans-sulfuration, one-carbon metabolism and related pathways; Copper homeostasis; Physico-chemical features and toxicity-associated pathways; One-carbon metabolism and related pathways; Oxidative stress response; Extracellular vesicles in the crosstalk of cardiac cells; Arsenic metabolism and reactive oxygen species generation; HDAC6 interactions in the central nervous system" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Platelet degranulation ; Detoxification of Reactive Oxygen Species" "17" "0" "1.050" "1.024" "1.048" "0.941" "0.910" "0.998" "0.921" "0.909" "0.944" "2016.6" "2116.6" "2065.2" "2113.3" "1897.1" "1834.6" "2011.6" "1857.7" "1834.0" "1904.3" "" "" "" "" "" "" "" "" "" "" "1889.5" "1751.5" "1917.2" "1633.6" "1617.0" "1752.8" "1838.0" "1649.4" "1834.0" "1833.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2083560476411538397" "False" "High" "IsMasterProtein" "O15047" "Histone-lysine N-methyltransferase SETD1A OS=Homo sapiens OX=9606 GN=SETD1A PE=1 SV=3" "0.000" "False" "30.235" "6" "10" "13" "10" "1707" "185.9" "5.14" "41.10" "10" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00856, Pf11764" "9739" "ENSG00000099381" "SETD1A" "A6NP62; hsa:9739; O15047; Q6PIF3; Q8TAJ6" "Histone modifications" "Formation of WDR5-containing histone-modifying complexes; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "4" "0" "1.081" "1.028" "1.077" "1.061" "1.088" "0.997" "1.066" "1.057" "1.111" "1496.7" "1618.5" "1538.7" "1611.9" "1588.6" "1629.0" "1491.7" "1594.8" "1582.2" "1662.1" "" "" "" "" "" "" "" "" "" "" "1402.4" "1339.3" "1428.5" "1246.1" "1354.1" "1556.4" "1363.0" "1416.1" "1582.2" "1600.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3364566389234349396" "False" "High" "IsMasterProtein" "Q04727" "Transducin-like enhancer protein 4 OS=Homo sapiens OX=9606 GN=TLE4 PE=1 SV=3" "0.000" "False" "30.185" "12" "10" "14" "10" "773" "83.7" "7.50" "44.18" "10" "cell-cell signaling;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf03920" "7091" "ENSG00000106829" "TLE4" "F8W6T6; hsa:7091; Q04727; Q3ZCS1; Q5T1Y2; Q6PCB3; Q9BZ07; Q9BZ08; Q9BZ09; Q9NSL3; Q9ULF9" "" "Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; NOTCH1 Intracellular Domain Regulates Transcription; Repression of WNT target genes" "4" "0" "0.974" "1.039" "0.929" "1.013" "0.983" "0.942" "1.000" "1.027" "0.993" "1773.5" "1727.9" "1842.7" "1648.1" "1796.6" "1743.2" "1671.3" "1773.8" "1821.9" "1760.2" "" "" "" "" "" "" "" "" "" "" "1661.8" "1429.8" "1710.7" "1274.0" "1531.4" "1665.5" "1527.1" "1574.9" "1821.9" "1694.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5468856902780976606" "False" "High" "IsMasterProtein" "O60884" "DnaJ homolog subfamily A member 2 OS=Homo sapiens OX=9606 GN=DNAJA2 PE=1 SV=1" "0.000" "False" "30.177" "21" "9" "21" "9" "412" "45.7" "6.48" "57.51" "9" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf00226, Pf00684, Pf01556" "10294" "ENSG00000069345" "DNAJA2" "B2R7L7; hsa:10294; O14711; O60884" "" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "1" "0" "0.873" "0.866" "0.833" "0.802" "0.792" "0.689" "0.733" "0.849" "0.826" "1352.8" "1180.8" "1171.9" "1127.1" "1084.6" "1071.6" "932.1" "992.3" "1148.8" "1117.5" "" "" "" "" "" "" "" "" "" "" "1267.6" "977.1" "1087.9" "871.3" "924.5" "1023.8" "851.6" "881.0" "1148.8" "1076.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3053469202622973433" "False" "High" "IsMasterProtein" "Q7L591" "Docking protein 3 OS=Homo sapiens OX=9606 GN=DOK3 PE=1 SV=2" "0.000" "False" "30.175" "18" "8" "14" "8" "496" "53.3" "7.77" "48.27" "8" "signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf02174" "79930" "ENSG00000146094" "DOK3" "E9PAT0; H7BXS0; hsa:79930; Q7L591; Q8N864; Q9BQB3; Q9H666" "5q35 copy number variation" "Neutrophil degranulation" "2" "0" "1.035" "1.017" "1.095" "1.038" "1.043" "1.015" "1.029" "0.983" "1.069" "983.4" "1017.9" "1000.4" "1077.0" "1021.0" "1025.9" "998.4" "1012.2" "966.7" "1051.3" "" "" "" "" "" "" "" "" "" "" "921.4" "842.3" "928.7" "832.6" "870.3" "980.2" "912.2" "898.7" "966.7" "1012.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8046944082778510554" "False" "High" "IsMasterProtein" "P32119" "Peroxiredoxin-2 OS=Homo sapiens OX=9606 GN=PRDX2 PE=1 SV=5" "0.000" "False" "30.172" "35" "7" "27" "6" "198" "21.9" "5.97" "88.35" "7" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00578, Pf10417" "7001" "ENSG00000167815" "PRDX2" "A8K0C0; hsa:7001; P31945; P32118; P32119; P35701; Q6FHG4; Q92763; Q9UC23" "Selenium micronutrient network; VEGFA-VEGFR2 signaling; HDAC6 interactions in the central nervous system" "TP53 Regulates Metabolic Genes; Detoxification of Reactive Oxygen Species; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "6" "0" "0.921" "0.946" "0.848" "0.890" "0.916" "0.899" "0.935" "0.903" "0.912" "1845.5" "1700.5" "1745.6" "1564.3" "1643.1" "1690.6" "1659.3" "1725.0" "1666.1" "1683.2" "" "" "" "" "" "" "" "" "" "" "1729.3" "1407.2" "1620.6" "1209.3" "1400.5" "1615.2" "1516.2" "1531.6" "1666.1" "1620.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "980650416735823729" "False" "High" "IsMasterProtein" "Q9UHD1" "Cysteine and histidine-rich domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHORDC1 PE=1 SV=2" "0.000" "False" "30.169" "30" "9" "17" "9" "332" "37.5" "7.87" "55.65" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf04968, Pf04969" "26973" "ENSG00000110172; ENSG00000285023" "CHORDC1" "B2R6P8; hsa:26973; Q6IN49; Q8WVL9; Q9H3D6; Q9UHD1" "" "" "0" "0" "0.918" "0.911" "0.884" "0.940" "0.942" "0.910" "0.914" "0.909" "0.917" "3011.7" "2764.5" "2744.3" "2663.0" "2832.2" "2838.2" "2741.5" "2752.1" "2738.1" "2760.6" "" "" "" "" "" "" "" "" "" "" "2822.0" "2287.6" "2547.7" "2058.6" "2414.1" "2711.6" "2505.0" "2443.6" "2738.1" "2658.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8889177674351520658" "False" "High" "IsMasterProtein" "Q8ND24" "RING finger protein 214 OS=Homo sapiens OX=9606 GN=RNF214 PE=1 SV=2" "0.000" "False" "30.143" "15" "11" "13" "11" "703" "77.6" "6.95" "36.93" "11" "" "" "other molecular function" "" "257160" "ENSG00000167257" "RNF214" "B2RUW0; B4DTD1; hsa:257160; Q8ND24" "" "" "0" "0" "1.040" "0.980" "1.086" "1.076" "1.054" "1.050" "0.989" "0.980" "1.013" "1240.8" "1290.5" "1216.2" "1347.0" "1335.6" "1307.7" "1302.3" "1227.0" "1215.5" "1256.6" "" "" "" "" "" "" "" "" "" "" "1162.6" "1067.9" "1129.1" "1041.3" "1138.4" "1249.4" "1190.0" "1089.5" "1215.5" "1209.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9120785921578449656" "False" "High" "IsMasterProtein" "A0A0B4J2D5" "Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial OS=Homo sapiens OX=9606 GN=GATD3B PE=5 SV=1" "0.000" "False" "30.125" "41" "8" "16" "8" "268" "28.1" "8.27" "51.12" "8" "" "mitochondrion" "" "" "8209" "" "GATD3B" "A0A0B4J2D5; A6NFJ6; A6NJY7; hsa:8209; O00650; O00660; O15011; O15012; P30042; P55346; P78474; Q92505; Q92507" "Gastric cancer network 1" "" "1" "0" "1.017" "0.957" "1.030" "0.997" "1.056" "1.031" "1.011" "0.991" "0.996" "1064.4" "1082.8" "1018.9" "1096.7" "1061.5" "1124.4" "1097.8" "1075.7" "1054.9" "1059.7" "" "" "" "" "" "" "" "" "" "" "997.3" "896.0" "945.9" "847.8" "904.8" "1074.3" "1003.1" "955.1" "1054.9" "1020.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1991199370327280785" "False" "High" "IsMasterProtein" "Q9HD26" "Golgi-associated PDZ and coiled-coil motif-containing protein OS=Homo sapiens OX=9606 GN=GOPC PE=1 SV=1" "0.000" "False" "30.102" "21" "9" "12" "9" "462" "50.5" "5.92" "38.26" "9" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00595" "57120" "ENSG00000047932" "GOPC" "A6NM30; hsa:57120; Q59FS4; Q969U8; Q9HD26" "" "RHOQ GTPase cycle; RHO GTPases regulate CFTR trafficking" "2" "0" "1.002" "0.980" "1.048" "0.928" "0.966" "0.903" "0.867" "0.922" "0.957" "542.4" "543.4" "531.3" "568.7" "503.3" "524.2" "489.6" "470.1" "500.0" "519.2" "" "" "" "" "" "" "" "" "" "" "508.3" "449.7" "493.3" "439.6" "429.0" "500.8" "447.4" "417.4" "500.0" "499.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3607998631011874723" "False" "High" "IsMasterProtein" "Q9UBQ7" "Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens OX=9606 GN=GRHPR PE=1 SV=1" "0.000" "False" "30.099" "32" "9" "13" "9" "328" "35.6" "7.39" "40.42" "9" "other metabolic processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00389, Pf02826" "9380" "ENSG00000137106" "GRHPR" "hsa:9380; Q5T945; Q9H3E9; Q9H636; Q9UBQ7; Q9UKX1" "" "Glyoxylate metabolism and glycine degradation" "1" "0" "0.881" "0.951" "0.988" "0.960" "0.977" "0.944" "0.981" "0.926" "0.978" "803.6" "708.3" "763.8" "794.1" "771.3" "785.3" "758.3" "788.2" "744.1" "785.5" "" "" "" "" "" "" "" "" "" "" "753.0" "586.1" "709.1" "613.9" "657.5" "750.3" "692.9" "699.9" "744.1" "756.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3304952133381549298" "False" "High" "IsMasterProtein" "Q99614" "Tetratricopeptide repeat protein 1 OS=Homo sapiens OX=9606 GN=TTC1 PE=1 SV=1" "0.000" "False" "30.060" "30" "9" "15" "9" "292" "33.5" "4.84" "49.39" "9" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00515, Pf13181" "7265" "ENSG00000113312" "TTC1" "B2RCT2; D3DQJ8; hsa:7265; Q99614; Q9BVT3" "" "" "0" "0" "1.158" "1.051" "0.925" "1.007" "1.096" "0.907" "1.024" "1.028" "1.054" "1622.3" "1878.5" "1704.3" "1500.3" "1633.9" "1778.6" "1471.9" "1660.7" "1668.3" "1709.8" "" "" "" "" "" "" "" "" "" "" "1520.1" "1554.4" "1582.2" "1159.8" "1392.7" "1699.2" "1344.9" "1474.5" "1668.3" "1646.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5981355964815445657" "False" "High" "IsMasterProtein" "P35611" "Alpha-adducin OS=Homo sapiens OX=9606 GN=ADD1 PE=1 SV=2" "0.000" "False" "30.026" "14" "9" "14" "8" "737" "80.9" "5.83" "47.22" "9" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "118" "ENSG00000087274" "ADD1" "A2A3N8; A2A3P0; B4DI79; D3DVR3; D3DVR4; D3DVR5; hsa:118; P35611; Q13734; Q14729; Q16156; Q86XM2; Q9UJB6" "" "XBP1(S) activates chaperone genes; Caspase-mediated cleavage of cytoskeletal proteins; Miscellaneous transport and binding events" "3" "0" "0.940" "0.976" "0.951" "0.990" "0.972" "0.963" "0.958" "0.988" "0.977" "1764.4" "1658.5" "1722.8" "1677.2" "1747.3" "1715.7" "1698.8" "1689.6" "1743.3" "1724.1" "" "" "" "" "" "" "" "" "" "" "1653.2" "1372.4" "1599.4" "1296.5" "1489.4" "1639.2" "1552.3" "1500.2" "1743.3" "1660.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8338185896590092974" "False" "High" "IsMasterProtein" "Q9H0B6" "Kinesin light chain 2 OS=Homo sapiens OX=9606 GN=KLC2 PE=1 SV=1" "0.000" "False" "30.010" "17" "10" "10" "7" "622" "68.9" "7.15" "29.74" "10" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf13424" "64837" "ENSG00000174996" "KLC2" "A8MXL7; B2RDY4; hsa:64837; Q9H0B6; Q9H9C8; Q9HA20" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation; RHO GTPases activate KTN1" "6" "0" "1.060" "0.961" "1.229" "1.063" "0.992" "1.114" "1.025" "1.009" "1.017" "868.2" "919.9" "834.2" "1067.0" "922.9" "861.1" "966.7" "890.1" "876.3" "883.3" "" "" "" "" "" "" "" "" "" "" "813.5" "761.2" "774.4" "824.8" "786.7" "822.7" "883.3" "790.3" "876.3" "850.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8307908846177998742" "False" "High" "IsMasterProtein" "P20248" "Cyclin-A2 OS=Homo sapiens OX=9606 GN=CCNA2 PE=1 SV=2" "0.000" "False" "29.947" "25" "9" "13" "9" "432" "48.5" "6.54" "36.54" "9" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00134, Pf02984, Pf16500" "890" "ENSG00000145386" "CCNA2" "A8K7B6; hsa:890; P20248; Q2M3U6; Q4W5P4; Q6LER8" "AMP-activated protein kinase signaling; Cell cycle; Retinoblastoma gene in cancer; Photodynamic therapy-induced AP-1 survival signaling; IL-18 signaling pathway; Acute myeloid leukemia; NF1 copy number variation syndrome" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; Regulation of TP53 Degradation; SCF(Skp2)-mediated degradation of p27/p21; Regulation of TP53 Activity through Phosphorylation; G2 Phase; Telomere Extension By Telomerase; Regulation of APC/C activators between G1/S and early anaphase; Senescence-Associated Secretory Phenotype (SASP); Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; p53-Dependent G1 DNA Damage Response; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes" "27" "0" "1.037" "1.007" "1.021" "1.062" "1.042" "1.026" "1.026" "1.051" "1.036" "525.7" "545.2" "529.6" "537.0" "558.3" "547.9" "539.4" "539.4" "552.3" "544.7" "" "" "" "" "" "" "" "" "" "" "492.6" "451.1" "491.6" "415.1" "475.9" "523.5" "492.9" "479.0" "552.3" "524.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6421674880825804013" "False" "High" "IsMasterProtein" "Q96C19" "EF-hand domain-containing protein D2 OS=Homo sapiens OX=9606 GN=EFHD2 PE=1 SV=1" "0.000" "False" "29.930" "40" "9" "13" "9" "240" "26.7" "5.20" "43.47" "9" "" "other membranes" "other molecular function" "Pf21008" "79180" "ENSG00000142634" "EFHD2" "hsa:79180; Q5JYW9; Q96C19" "" "RHOD GTPase cycle" "1" "0" "1.010" "0.993" "0.926" "0.954" "0.967" "0.956" "1.018" "0.948" "0.948" "2883.8" "2913.5" "2865.1" "2669.4" "2751.5" "2787.8" "2756.6" "2935.6" "2734.9" "2734.0" "" "" "" "" "" "" "" "" "" "" "2702.1" "2410.9" "2659.8" "2063.6" "2345.3" "2663.5" "2518.8" "2606.5" "2734.9" "2632.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7331162755834209068" "False" "High" "IsMasterProtein" "Q8IWR0" "Zinc finger CCCH domain-containing protein 7A OS=Homo sapiens OX=9606 GN=ZC3H7A PE=1 SV=1" "0.000" "False" "29.903" "11" "12" "14" "12" "971" "110.5" "7.30" "36.09" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00642" "29066" "ENSG00000122299" "ZC3H7A" "D3DUG5; hsa:29066; Q8IWR0; Q9NPE9" "" "" "0" "0" "1.010" "1.032" "1.035" "1.047" "1.043" "1.006" "0.989" "1.027" "1.051" "1354.0" "1367.4" "1396.9" "1402.1" "1418.2" "1412.6" "1362.0" "1338.8" "1390.7" "1423.7" "" "" "" "" "" "" "" "" "" "" "1268.7" "1131.5" "1296.8" "1083.9" "1208.9" "1349.6" "1244.5" "1188.7" "1390.7" "1370.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3264991097181317635" "False" "High" "IsMasterProtein" "Q9NPF5" "DNA methyltransferase 1-associated protein 1 OS=Homo sapiens OX=9606 GN=DMAP1 PE=1 SV=1" "0.000" "False" "29.874" "22" "9" "12" "9" "467" "53.0" "9.50" "33.30" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05499, Pf16282" "55929" "ENSG00000178028" "DMAP1" "A8K001; D3DPY8; hsa:55929; Q0JSM4; Q5TG41; Q7Z3H7; Q9H0S8; Q9NPF5; Q9P2C2" "" "HATs acetylate histones" "1" "0" "1.035" "1.019" "1.046" "1.027" "1.048" "1.035" "0.985" "1.021" "1.033" "963.0" "996.6" "981.5" "1007.7" "989.2" "1009.7" "997.0" "948.7" "983.6" "994.4" "" "" "" "" "" "" "" "" "" "" "902.4" "824.7" "911.2" "779.0" "843.2" "964.7" "911.0" "842.3" "983.6" "957.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6603036499622523787" "False" "High" "IsMasterProtein" "Q9Y2S7" "Polymerase delta-interacting protein 2 OS=Homo sapiens OX=9606 GN=POLDIP2 PE=1 SV=1" "0.000" "False" "29.868" "32" "11" "16" "11" "368" "42.0" "8.63" "46.70" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf04379, Pf08755" "26073" "ENSG00000004142" "POLDIP2" "B2R846; hsa:26073; Q96JE4; Q9Y2S7" "" "" "0" "0" "0.990" "0.984" "0.993" "0.972" "1.106" "0.924" "1.011" "1.006" "1.007" "1750.7" "1733.4" "1722.4" "1738.6" "1701.6" "1936.3" "1617.7" "1770.2" "1761.2" "1762.1" "" "" "" "" "" "" "" "" "" "" "1640.4" "1434.4" "1599.1" "1344.0" "1450.4" "1849.9" "1478.1" "1571.8" "1761.2" "1696.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6299048692266605018" "False" "High" "IsMasterProtein" "Q14161" "ARF GTPase-activating protein GIT2 OS=Homo sapiens OX=9606 GN=GIT2 PE=1 SV=2" "0.000" "False" "29.865" "11" "10" "14" "7" "759" "84.5" "7.23" "41.17" "10" "transport;developmental processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf01412, Pf08518, Pf12205, Pf16559" "9815" "ENSG00000139436" "GIT2" "hsa:9815; Q14161; Q86U59; Q96CI2; Q9BV91; Q9Y5V2" "Integrin-mediated cell adhesion" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle" "9" "0" "0.947" "0.959" "0.970" "0.978" "1.048" "0.958" "0.916" "0.908" "0.993" "1457.1" "1379.1" "1397.2" "1413.2" "1424.9" "1526.8" "1395.8" "1334.9" "1323.4" "1446.5" "" "" "" "" "" "" "" "" "" "" "1365.3" "1141.2" "1297.1" "1092.5" "1214.6" "1458.8" "1275.4" "1185.3" "1323.4" "1392.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2660523182149503333" "False" "High" "IsMasterProtein" "Q9UKK9" "ADP-sugar pyrophosphatase OS=Homo sapiens OX=9606 GN=NUDT5 PE=1 SV=1" "0.000" "False" "29.864" "26" "6" "14" "6" "219" "24.3" "4.94" "54.93" "6" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00293" "11164" "ENSG00000165609" "NUDT5" "A8K516; hsa:11164; Q6IAG0; Q9UH49; Q9UKK9" "" "Phosphate bond hydrolysis by NUDT proteins" "1" "0" "0.992" "0.896" "0.945" "1.012" "1.058" "0.846" "0.965" "0.941" "0.935" "3159.9" "3133.5" "2830.0" "2985.2" "3196.4" "3344.3" "2674.2" "3050.0" "2972.9" "2953.9" "" "" "" "" "" "" "" "" "" "" "2960.8" "2592.9" "2627.3" "2307.7" "2724.6" "3195.1" "2443.5" "2708.1" "2972.9" "2844.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7223228418441482962" "False" "High" "IsMasterProtein" "Q15648" "Mediator of RNA polymerase II transcription subunit 1 OS=Homo sapiens OX=9606 GN=MED1 PE=1 SV=4" "0.000" "False" "29.842" "6" "10" "10" "10" "1581" "168.4" "8.73" "31.87" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf10744" "5469" "ENSG00000125686" "MED1" "A2RRQ6; hsa:5469; O43810; O75447; Q15648; Q6P9H7; Q6PK58; Q9HD39" "Energy metabolism; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Non-genomic actions of 1,25 dihydroxyvitamin D3; 17q12 copy number variation syndrome" "Cytoprotection by HMOX1; Estrogen-dependent gene expression; Transcriptional activation of mitochondrial biogenesis; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nuclear Receptor transcription pathway; Activation of gene expression by SREBF (SREBP); RORA activates gene expression" "18" "0" "0.960" "0.975" "1.000" "0.991" "0.977" "0.955" "0.924" "0.985" "0.974" "1135.9" "1090.6" "1107.6" "1136.1" "1125.2" "1110.0" "1085.3" "1049.0" "1118.5" "1106.0" "" "" "" "" "" "" "" "" "" "" "1064.3" "902.4" "1028.2" "878.2" "959.1" "1060.5" "991.7" "931.4" "1118.5" "1065.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8500687369034294287" "False" "High" "IsMasterProtein" "P62820" "Ras-related protein Rab-1A OS=Homo sapiens OX=9606 GN=RAB1A PE=1 SV=3" "0.000" "False" "29.839" "43" "9" "15" "2" "205" "22.7" "6.21" "48.72" "9" "cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5861" "ENSG00000138069" "RAB1A" "hsa:5861; P11476; P62820; Q6FIE7; Q96N61; Q9Y3T2" "" "RAB GEFs exchange GTP for GDP on RABs; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; COPII-mediated vesicle transport; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization" "6" "0" "0.940" "0.921" "0.998" "0.971" "1.056" "0.991" "1.048" "0.890" "0.948" "159.6" "149.9" "147.1" "159.2" "154.9" "168.5" "158.2" "167.2" "142.1" "151.3" "" "" "" "" "" "" "" "" "" "" "149.5" "124.1" "136.5" "123.1" "132.1" "161.0" "144.6" "148.5" "142.1" "145.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5054374183751915473" "False" "High" "IsMasterProtein" "Q13884" "Beta-1-syntrophin OS=Homo sapiens OX=9606 GN=SNTB1 PE=1 SV=3" "0.000" "False" "29.812" "21" "10" "11" "9" "538" "58.0" "8.63" "34.13" "10" "other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00595, Pf18012" "6641" "ENSG00000172164" "SNTB1" "A8K9E0; hsa:6641; O14912; Q13884; Q4KMG8" "IL-18 signaling pathway; 13q12.12 copy number variation" "" "2" "1" "0.988" "1.012" "0.949" "0.993" "1.070" "0.972" "0.975" "1.019" "1.038" "860.5" "849.9" "870.8" "816.6" "854.4" "920.8" "836.8" "838.7" "876.5" "893.1" "" "" "" "" "" "" "" "" "" "" "806.3" "703.2" "808.4" "631.2" "728.3" "879.7" "764.6" "744.7" "876.5" "859.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2236702861585061595" "False" "High" "IsMasterProtein" "P57721" "Poly(rC)-binding protein 3 OS=Homo sapiens OX=9606 GN=PCBP3 PE=1 SV=2" "0.000" "False" "29.757" "20" "6" "14" "1" "371" "39.4" "8.07" "53.24" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity" "Pf00013, Pf07650" "54039" "ENSG00000183570" "PCBP3" "A8MPS2; A8MQ26; B7WNN9; B7WPC1; P57721; Q8N9K6; Q96EP6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5631363744109016659" "False" "High" "IsMasterProtein" "Cont_Q04695" "Keratin, type I cytoskeletal 17 OS=Homo sapiens OX=9606 GN=KRT17 PE=1 SV=2" "0.000" "True" "29.730" "17" "10" "15" "1" "432" "48.1" "5.02" "40.64" "10" "cell organization and biogenesis;other biological processes" "plasma membrane;cytosol;cytoskeleton" "other molecular function" "Pf00038" "3872" "ENSCABG00000017365; ENSG00000128422" "KRT17" "A0A8C0IX11; A5Z1M9; A5Z1N0; A5Z1N1; A5Z1N2; A6NDV6; A6NKQ2; hsa:3872; Q04695; Q6IP98; Q8N1P6" "1p36 copy number variation syndrome; Pancreatic cancer subtypes" "Formation of the cornified envelope" "4" "0" "1.236" "0.874" "0.843" "0.932" "0.845" "3.173" "0.858" "0.765" "0.987" "160.3" "198.1" "140.0" "135.1" "149.4" "135.4" "508.7" "137.5" "122.7" "158.3" "" "" "" "" "" "" "" "" "" "" "150.2" "163.9" "130.0" "104.4" "127.4" "129.4" "464.8" "122.1" "122.7" "152.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5241599952766811941" "False" "High" "IsMasterProtein" "P09211" "Glutathione S-transferase P OS=Homo sapiens OX=9606 GN=GSTP1 PE=1 SV=2" "0.000" "False" "29.711" "43" "7" "16" "7" "210" "23.3" "5.64" "59.84" "7" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02798, Pf14497" "2950" "ENSG00000084207" "GSTP1" "hsa:2950; O00460; P09211; Q15690; Q5TZY3" "Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Exercise-induced circadian regulation; Omega-6-fatty acids in senescence; Arachidonate epoxygenase / epoxide hydrolase; Metapathway biotransformation Phase I and II" "Neutrophil degranulation; Paracetamol ADME; Detoxification of Reactive Oxygen Species; Glutathione conjugation" "11" "0" "0.926" "1.031" "0.915" "0.964" "0.987" "0.926" "1.014" "0.983" "0.969" "1794.7" "1662.5" "1850.3" "1641.5" "1729.5" "1770.8" "1661.2" "1820.0" "1764.0" "1739.6" "" "" "" "" "" "" "" "" "" "" "1681.6" "1375.7" "1717.8" "1269.0" "1474.2" "1691.8" "1517.9" "1615.9" "1764.0" "1675.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8973265240341480372" "False" "High" "IsMasterProtein" "Q06203" "Amidophosphoribosyltransferase OS=Homo sapiens OX=9606 GN=PPAT PE=1 SV=1" "0.000" "False" "29.710" "21" "10" "15" "10" "517" "57.4" "6.76" "51.52" "10" "other metabolic processes" "cytosol" "other molecular function" "Pf00156, Pf13522" "5471" "ENSG00000128059" "PPAT" "hsa:5471; Q06203" "Fluoropyrimidine activity; Metabolic reprogramming in colon cancer" "Purine ribonucleoside monophosphate biosynthesis" "3" "0" "0.961" "0.968" "0.994" "0.968" "0.964" "0.952" "0.993" "0.966" "0.952" "1531.3" "1471.7" "1483.0" "1521.5" "1482.7" "1477.0" "1457.6" "1520.0" "1480.0" "1458.0" "" "" "" "" "" "" "" "" "" "" "1434.9" "1217.8" "1376.8" "1176.2" "1263.8" "1411.1" "1331.9" "1349.6" "1480.0" "1403.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5104868076877432039" "False" "High" "IsMasterProtein" "Q9HC38" "Glyoxalase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GLOD4 PE=1 SV=1" "0.000" "False" "29.705" "24" "8" "15" "8" "313" "34.8" "5.60" "49.03" "8" "" "mitochondrion" "" "Pf21207, Pf21701" "51031" "ENSG00000167699" "GLOD4" "D3DTG9; D3DTH1; hsa:51031; Q96B89; Q9H3J8; Q9HC37; Q9HC38; Q9NVN1" "" "" "0" "0" "0.989" "0.959" "0.929" "0.926" "0.899" "0.877" "0.980" "0.933" "0.933" "1414.5" "1399.2" "1356.7" "1313.6" "1309.5" "1271.6" "1240.2" "1386.2" "1319.3" "1319.7" "" "" "" "" "" "" "" "" "" "" "1325.4" "1157.8" "1259.6" "1015.5" "1116.2" "1214.9" "1133.2" "1230.8" "1319.3" "1270.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3042753504910158627" "False" "High" "IsMasterProtein" "P13804" "Electron transfer flavoprotein subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ETFA PE=1 SV=1" "0.000" "False" "29.696" "35" "9" "14" "9" "333" "35.1" "8.38" "48.02" "9" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00766, Pf01012" "2108" "ENSG00000140374" "ETFA" "B4DT43; hsa:2108; P13804; Q53XN3" "" "Respiratory electron transport" "1" "0" "0.873" "0.959" "0.888" "0.892" "0.896" "0.895" "0.879" "0.861" "0.872" "1700.3" "1484.6" "1629.8" "1510.4" "1517.2" "1523.7" "1522.5" "1493.9" "1464.3" "1483.1" "" "" "" "" "" "" "" "" "" "" "1593.2" "1228.5" "1513.0" "1167.6" "1293.2" "1455.8" "1391.1" "1326.5" "1464.3" "1428.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5815145421053809259" "False" "High" "IsMasterProtein" "Q16543" "Hsp90 co-chaperone Cdc37 OS=Homo sapiens OX=9606 GN=CDC37 PE=1 SV=1" "0.000" "False" "29.690" "25" "9" "19" "9" "378" "44.4" "5.25" "59.84" "9" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf03234, Pf08564, Pf08565" "11140" "ENSG00000105401" "CDC37" "hsa:11140; Q16543; Q53YA2" "TNF-alpha signaling pathway; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Interactions between LOXL4 and oxidative stress pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "RHOBTB2 GTPase cycle; Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "27" "0" "1.037" "0.951" "0.958" "0.996" "0.946" "0.954" "0.959" "1.044" "0.983" "2112.4" "2190.4" "2008.3" "2022.6" "2104.9" "1997.5" "2014.6" "2025.8" "2205.6" "2077.0" "" "" "" "" "" "" "" "" "" "" "1979.3" "1812.5" "1864.5" "1563.6" "1794.2" "1908.4" "1840.8" "1798.7" "2205.6" "1999.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "692688187917917011" "False" "High" "IsMasterProtein" "P82979" "SAP domain-containing ribonucleoprotein OS=Homo sapiens OX=9606 GN=SARNP PE=1 SV=3" "0.000" "False" "29.682" "41" "8" "16" "8" "210" "23.7" "6.42" "51.11" "8" "other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037" "84324" "ENSG00000205323" "SARNP" "A8K393; hsa:84324; P82979; Q9P066" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "1.110" "1.028" "1.087" "1.079" "1.069" "1.109" "1.086" "1.133" "1.054" "1930.9" "2143.2" "1985.5" "2098.7" "2083.2" "2064.7" "2141.9" "2097.8" "2188.3" "2035.7" "" "" "" "" "" "" "" "" "" "" "1809.3" "1773.5" "1843.3" "1622.4" "1775.7" "1972.6" "1957.2" "1862.6" "2188.3" "1960.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8048887560610190463" "False" "High" "IsMasterProtein" "Q5JPH6" "Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial OS=Homo sapiens OX=9606 GN=EARS2 PE=1 SV=2" "0.000" "False" "29.681" "17" "9" "10" "9" "523" "58.7" "8.76" "36.14" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00749, Pf19269" "124454" "ENSG00000103356" "EARS2" "B3KTT2; D3DWF1; hsa:124454; Q5JPH6; Q86YH3; Q8TF31" "" "Mitochondrial tRNA aminoacylation" "1" "0" "0.960" "1.011" "1.002" "0.971" "0.979" "0.973" "0.953" "0.983" "0.982" "2011.2" "1929.8" "2033.9" "2014.3" "1952.6" "1969.1" "1957.2" "1915.8" "1977.8" "1974.2" "" "" "" "" "" "" "" "" "" "" "1884.4" "1596.9" "1888.3" "1557.2" "1664.4" "1881.2" "1788.4" "1701.0" "1977.8" "1900.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4844416647535235754" "False" "High" "IsMasterProtein" "O00233" "26S proteasome non-ATPase regulatory subunit 9 OS=Homo sapiens OX=9606 GN=PSMD9 PE=1 SV=3" "0.000" "False" "29.656" "45" "9" "13" "9" "223" "24.7" "6.95" "41.35" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf17820, Pf18265" "5715" "ENSG00000110801" "PSMD9" "B2RD35; G3V1Q6; hsa:5715; O00233; Q9BQ42" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "1.086" "1.041" "1.052" "1.049" "1.005" "1.048" "1.022" "0.938" "1.021" "758.2" "823.4" "789.4" "797.9" "795.3" "762.0" "794.7" "775.2" "711.6" "774.4" "" "" "" "" "" "" "" "" "" "" "710.5" "681.4" "732.9" "616.8" "677.9" "728.0" "726.1" "688.3" "711.6" "745.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6856624260157841827" "False" "High" "IsMasterProtein" "O60256" "Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Homo sapiens OX=9606 GN=PRPSAP2 PE=1 SV=1" "0.000" "False" "29.631" "28" "9" "15" "7" "369" "40.9" "7.44" "44.96" "9" "other metabolic processes;developmental processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf13793, Pf14572" "5636" "ENSG00000141127" "PRPSAP2" "B4E1M8; B4E329; B7ZKZ1; E7EMY2; hsa:5636; O60256; Q6IAS2" "" "" "0" "2" "0.986" "0.941" "1.025" "0.983" "0.943" "0.963" "0.911" "0.932" "0.952" "1243.0" "1226.0" "1169.7" "1273.6" "1221.9" "1172.3" "1197.5" "1132.7" "1158.6" "1184.0" "" "" "" "" "" "" "" "" "" "" "1164.7" "1014.5" "1085.9" "984.5" "1041.5" "1120.0" "1094.2" "1005.7" "1158.6" "1140.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6449077897622524501" "False" "High" "IsMasterProtein" "O95551" "Tyrosyl-DNA phosphodiesterase 2 OS=Homo sapiens OX=9606 GN=TDP2 PE=1 SV=1" "0.000" "False" "29.592" "29" "8" "11" "8" "362" "40.9" "5.10" "39.45" "8" "DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372, Pf14555" "51567" "ENSG00000111802" "TDP2" "B4DKL8; B4DQ95; O95551; Q2TBE2; Q5JYM0; Q7Z6U5; Q9NUK5; Q9NYY9" "Oxidative damage response" "Nonhomologous End-Joining (NHEJ)" "2" "0" "0.961" "1.038" "0.998" "1.020" "0.999" "1.002" "0.997" "0.992" "1.009" "1068.1" "1026.8" "1108.4" "1065.5" "1089.9" "1067.0" "1070.3" "1065.3" "1059.9" "1077.8" "" "" "" "" "" "" "" "" "" "" "1000.8" "849.6" "1029.1" "823.7" "929.0" "1019.4" "978.0" "945.9" "1059.9" "1037.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8740518017781001578" "False" "High" "IsMasterProtein" "Q8WW12" "PEST proteolytic signal-containing nuclear protein OS=Homo sapiens OX=9606 GN=PCNP PE=1 SV=2" "0.000" "False" "29.555" "51" "8" "14" "8" "178" "18.9" "7.49" "45.28" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "nucleus" "" "Pf15473" "57092" "ENSG00000081154" "PCNP" "B2RBE7; D3DN52; hsa:57092; Q53GF3; Q6AI44; Q8WW12; Q96CU3; Q9NS81" "" "" "0" "0" "0.991" "0.959" "0.892" "0.955" "0.951" "0.910" "1.010" "0.942" "0.897" "1131.5" "1121.6" "1085.0" "1009.2" "1080.6" "1076.3" "1029.7" "1142.6" "1065.9" "1015.4" "" "" "" "" "" "" "" "" "" "" "1060.2" "928.1" "1007.3" "780.1" "921.0" "1028.3" "940.9" "1014.5" "1065.9" "977.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2095194651549531862" "False" "High" "IsMasterProtein" "O95487" "Protein transport protein Sec24B OS=Homo sapiens OX=9606 GN=SEC24B PE=1 SV=2" "0.000" "False" "29.549" "10" "10" "12" "10" "1268" "137.3" "6.67" "36.44" "10" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10427" "ENSG00000138802" "SEC24B" "B7ZKM8; B7ZKN4; hsa:10427; O95487; Q0VG08" "Sterol regulatory element-binding proteins (SREBP) signaling" "COPII-mediated vesicle transport; MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "7" "0" "1.063" "1.062" "1.216" "1.134" "1.101" "1.133" "1.118" "1.107" "1.143" "870.6" "925.7" "924.7" "1058.8" "987.7" "958.5" "986.2" "973.2" "963.5" "995.4" "" "" "" "" "" "" "" "" "" "" "815.7" "766.0" "858.4" "818.5" "841.9" "915.7" "901.1" "864.1" "963.5" "958.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7971041458510100973" "False" "High" "IsMasterProtein" "P61201" "COP9 signalosome complex subunit 2 OS=Homo sapiens OX=9606 GN=COPS2 PE=1 SV=1" "0.000" "False" "29.505" "23" "10" "14" "10" "443" "51.6" "5.53" "43.39" "10" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01399" "9318" "ENSG00000166200" "COPS2" "hsa:9318; O88950; P61201; Q15647; Q6FGP4; Q9BY54; Q9R249; Q9UNI2; Q9UNQ5" "Ciliary landscape" "Neddylation; Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER" "6" "0" "0.943" "0.992" "0.935" "0.977" "0.990" "0.919" "0.978" "0.966" "0.937" "1862.9" "1757.3" "1847.1" "1741.8" "1820.0" "1845.1" "1712.9" "1821.6" "1799.2" "1746.4" "" "" "" "" "" "" "" "" "" "" "1745.6" "1454.2" "1714.8" "1346.5" "1551.3" "1762.8" "1565.1" "1617.4" "1799.2" "1681.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-15854148761745197" "False" "High" "IsMasterProtein" "Q6IN85" "Serine/threonine-protein phosphatase 4 regulatory subunit 3A OS=Homo sapiens OX=9606 GN=PPP4R3A PE=1 SV=1" "0.000" "False" "29.411" "11" "9" "11" "7" "833" "95.3" "4.94" "33.81" "9" "stress response" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf04802" "55671" "ENSG00000100796" "PPP4R3A" "hsa:55671; Q69YK6; Q6IN85; Q86U23; Q86YI7; Q8IVG1; Q9H3F1; Q9H7U8; Q9NV01; Q9NWP1" "16p11.2 proximal deletion syndrome" "" "1" "2" "0.948" "0.980" "1.025" "1.010" "0.961" "0.973" "0.960" "0.975" "0.999" "1251.8" "1186.6" "1226.4" "1282.5" "1264.4" "1202.7" "1218.0" "1201.4" "1219.9" "1250.6" "" "" "" "" "" "" "" "" "" "" "1172.9" "981.9" "1138.6" "991.5" "1077.8" "1149.0" "1112.9" "1066.7" "1219.9" "1204.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1018884242771776576" "False" "High" "IsMasterProtein" "P30048" "Thioredoxin-dependent peroxide reductase, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX3 PE=1 SV=3" "0.000" "False" "29.333" "31" "7" "16" "7" "256" "27.7" "7.78" "49.81" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00578, Pf10417" "10935" "ENSG00000165672" "PRDX3" "B2R7Z0; D3DRC9; E9PH29; hsa:10935; P30048; P35690; Q0D2H1; Q13776; Q5T5V2; Q96HK4" "Selenium micronutrient network" "Detoxification of Reactive Oxygen Species" "2" "0" "0.976" "1.013" "1.107" "1.079" "1.121" "1.019" "0.970" "1.054" "0.991" "1796.4" "1753.3" "1819.3" "1988.1" "1938.2" "2014.7" "1830.8" "1742.8" "1894.3" "1781.1" "" "" "" "" "" "" "" "" "" "" "1683.3" "1450.8" "1689.0" "1536.9" "1652.1" "1924.8" "1672.9" "1547.5" "1894.3" "1715.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3689472973843486022" "False" "High" "IsMasterProtein" "O00505" "Importin subunit alpha-4 OS=Homo sapiens OX=9606 GN=KPNA3 PE=1 SV=2" "0.000" "False" "29.328" "18" "9" "16" "5" "521" "57.8" "4.94" "51.09" "9" "cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3839" "ENSG00000102753" "KPNA3" "hsa:3839; O00191; O00505; O43195; Q5JVM9; Q8IYQ9; Q96AA7" "" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways" "2" "3" "1.061" "1.081" "1.054" "1.058" "1.055" "1.079" "1.055" "1.073" "1.056" "1795.4" "1904.8" "1941.5" "1891.8" "1900.3" "1894.7" "1936.8" "1895.0" "1927.0" "1896.8" "" "" "" "" "" "" "" "" "" "" "1682.3" "1576.2" "1802.5" "1462.5" "1619.8" "1810.2" "1769.7" "1682.6" "1927.0" "1826.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9144815558027084880" "False" "High" "IsMasterProtein" "Q96FV9" "THO complex subunit 1 OS=Homo sapiens OX=9606 GN=THOC1 PE=1 SV=1" "0.000" "False" "29.288" "16" "10" "12" "10" "657" "75.6" "4.98" "35.29" "10" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00531, Pf11957" "9984" "ENSG00000079134" "THOC1" "B2RBP6; hsa:9984; Q15219; Q64I72; Q64I73; Q96FV9" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "1.020" "1.084" "1.110" "1.162" "1.124" "1.264" "1.364" "1.278" "1.184" "1206.1" "1229.8" "1308.0" "1339.0" "1401.4" "1356.3" "1524.1" "1645.3" "1541.7" "1428.3" "" "" "" "" "" "" "" "" "" "" "1130.1" "1017.6" "1214.3" "1035.1" "1194.5" "1295.8" "1392.6" "1460.8" "1541.7" "1375.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "687508345564059484" "False" "High" "IsMasterProtein" "Q15436" "Protein transport protein Sec23A OS=Homo sapiens OX=9606 GN=SEC23A PE=1 SV=2" "0.000" "False" "29.286" "17" "11" "15" "10" "765" "86.1" "7.08" "43.38" "11" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10484" "ENSG00000100934" "SEC23A" "B2R5P4; B3KXI2; hsa:10484; Q15436; Q8NE16" "Sterol regulatory element-binding proteins (SREBP) signaling" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF)" "7" "0" "1.037" "1.028" "1.197" "1.061" "1.085" "1.059" "0.980" "1.026" "1.027" "855.8" "887.5" "879.9" "1024.2" "907.6" "928.3" "906.5" "839.1" "878.0" "878.7" "" "" "" "" "" "" "" "" "" "" "801.9" "734.4" "816.8" "791.7" "773.7" "886.9" "828.3" "745.0" "878.0" "846.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3461094019956647414" "False" "High" "IsMasterProtein" "Q96KQ7" "Histone-lysine N-methyltransferase EHMT2 OS=Homo sapiens OX=9606 GN=EHMT2 PE=1 SV=3" "0.000" "False" "29.281" "8" "11" "13" "10" "1210" "132.3" "5.45" "42.32" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00023, Pf00856, Pf05033, Pf21533" "10919" "ENSG00000204371; ENSG00000206376; ENSG00000227333; ENSG00000232045; ENSG00000236759; ENSG00000238134" "EHMT2" "B0UZY2; hsa:10919; Q14349; Q5JP83; Q5JQ92; Q5JQA1; Q5JQG3; Q6PK06; Q96KQ7; Q96MH5; Q96QD0; Q9UQL8; Q9Y331" "Histone modifications; Ethanol effects on histone modifications; MTHFR deficiency" "Transcriptional Regulation by E2F6; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; PKMTs methylate histone lysines; Regulation of TP53 Activity through Methylation; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" "10" "0" "0.984" "1.007" "0.987" "0.974" "0.996" "1.008" "1.039" "1.046" "1.003" "1270.5" "1250.3" "1278.9" "1254.6" "1237.0" "1265.7" "1280.8" "1319.7" "1328.6" "1274.0" "" "" "" "" "" "" "" "" "" "" "1190.5" "1034.6" "1187.3" "969.9" "1054.4" "1209.3" "1170.3" "1171.7" "1328.6" "1226.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1726456948051343577" "False" "High" "IsMasterProtein" "Q96G46" "tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like OS=Homo sapiens OX=9606 GN=DUS3L PE=1 SV=2" "0.000" "False" "29.218" "21" "10" "10" "10" "650" "72.5" "8.05" "36.22" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "" "other molecular function" "Pf01207" "56931" "ENSG00000141994" "DUS3L" "hsa:56931; Q96G46; Q96HM5; Q9BSU4; Q9H877; Q9NPR1" "" "" "0" "0" "1.000" "1.010" "1.065" "1.007" "1.009" "0.960" "0.974" "0.966" "1.011" "1390.0" "1390.5" "1403.7" "1480.1" "1399.6" "1402.8" "1334.0" "1354.2" "1342.1" "1405.5" "" "" "" "" "" "" "" "" "" "" "1302.5" "1150.6" "1303.1" "1144.2" "1192.9" "1340.3" "1218.9" "1202.4" "1342.1" "1353.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1150602487247342071" "False" "High" "IsMasterProtein" "Q92890" "Ubiquitin recognition factor in ER-associated degradation protein 1 OS=Homo sapiens OX=9606 GN=UFD1 PE=1 SV=3" "0.000" "False" "29.191" "30" "9" "13" "9" "307" "34.5" "6.70" "40.12" "9" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03152" "7353" "ENSG00000070010" "UFD1" "A8MW31; hsa:7353; Q92890; Q9Y5N0" "22q11.2 copy number variation syndrome" "Ub-specific processing proteases; Neddylation; KEAP1-NFE2L2 pathway; Translesion Synthesis by POLH" "5" "0" "0.996" "1.013" "0.994" "0.959" "1.065" "1.004" "0.989" "1.005" "1.029" "1016.9" "1012.7" "1030.2" "1011.1" "975.4" "1083.5" "1021.4" "1005.3" "1022.3" "1046.5" "" "" "" "" "" "" "" "" "" "" "952.9" "838.0" "956.4" "781.6" "831.4" "1035.2" "933.3" "892.6" "1022.3" "1007.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1626409123411173154" "False" "High" "IsMasterProtein" "Q99598" "Translin-associated protein X OS=Homo sapiens OX=9606 GN=TSNAX PE=1 SV=1" "0.000" "False" "29.171" "35" "10" "15" "10" "290" "33.1" "6.55" "42.68" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf01997" "7257" "ENSG00000116918" "TSNAX" "B1APC6; hsa:7257; Q99598" "" "Small interfering RNA (siRNA) biogenesis" "1" "0" "1.009" "0.987" "0.956" "0.957" "1.005" "0.897" "0.926" "1.042" "0.978" "1879.2" "1895.9" "1855.5" "1797.4" "1798.8" "1889.1" "1685.6" "1739.9" "1957.7" "1837.4" "" "" "" "" "" "" "" "" "" "" "1760.8" "1568.9" "1722.6" "1389.5" "1533.2" "1804.8" "1540.2" "1544.9" "1957.7" "1769.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4765552648658305889" "False" "High" "IsMasterProtein" "Q96JH7" "Deubiquitinating protein VCPIP1 OS=Homo sapiens OX=9606 GN=VCPIP1 PE=1 SV=2" "0.000" "False" "29.167" "9" "11" "11" "11" "1222" "134.2" "7.20" "30.67" "11" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02338, Pf19437, Pf21403" "80124" "ENSG00000175073" "VCPIP1" "hsa:80124; Q504T4; Q86T93; Q86W01; Q8N3A9; Q96JH7; Q9H5R8" "Alstrom syndrome" "Ovarian tumor domain proteases" "2" "0" "1.101" "1.040" "1.092" "1.100" "1.040" "1.017" "1.016" "1.065" "1.064" "376.7" "414.6" "391.8" "411.2" "414.3" "391.8" "383.1" "382.6" "401.2" "400.9" "" "" "" "" "" "" "" "" "" "" "352.9" "343.1" "363.7" "317.8" "353.1" "374.3" "350.1" "339.7" "401.2" "386.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4969785199518402327" "False" "High" "IsMasterProtein" "Q13098" "COP9 signalosome complex subunit 1 OS=Homo sapiens OX=9606 GN=GPS1 PE=1 SV=4" "0.000" "False" "29.160" "18" "8" "17" "8" "491" "55.5" "6.74" "54.04" "8" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01399, Pf10602, Pf21151" "2873" "ENSG00000169727" "GPS1" "hsa:2873; Q13098; Q8NA10; Q9BWL1" "" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER" "5" "0" "0.985" "0.978" "1.059" "0.970" "0.986" "0.994" "0.914" "0.961" "0.960" "1688.1" "1662.6" "1651.3" "1787.6" "1637.4" "1663.7" "1677.8" "1543.4" "1621.9" "1620.8" "" "" "" "" "" "" "" "" "" "" "1581.8" "1375.8" "1533.0" "1381.9" "1395.7" "1589.5" "1533.1" "1370.4" "1621.9" "1560.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7169835918379755143" "False" "High" "IsMasterProtein" "P39687" "Acidic leucine-rich nuclear phosphoprotein 32 family member A OS=Homo sapiens OX=9606 GN=ANP32A PE=1 SV=1" "0.000" "False" "29.153" "27" "8" "14" "5" "249" "28.6" "4.09" "47.13" "8" "transport;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf14580" "8125" "ENSG00000140350" "ANP32A" "B2R6T4; hsa:8125; P39687; Q53FK4; Q5J8L8; Q7M4N6" "IL-18 signaling pathway" "HuR (ELAVL1) binds and stabilizes mRNA" "2" "3" "1.021" "0.977" "0.898" "0.862" "0.877" "0.875" "0.888" "0.845" "0.892" "1669.0" "1703.6" "1631.2" "1498.5" "1439.5" "1463.1" "1460.4" "1482.5" "1410.4" "1488.4" "" "" "" "" "" "" "" "" "" "" "1563.9" "1409.7" "1514.4" "1158.4" "1227.0" "1397.8" "1334.4" "1316.3" "1410.4" "1433.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2283450593618715734" "False" "High" "IsMasterProtein" "P41240" "Tyrosine-protein kinase CSK OS=Homo sapiens OX=9606 GN=CSK PE=1 SV=1" "0.000" "False" "29.146" "20" "9" "11" "9" "450" "50.7" "7.06" "34.86" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "1445" "ENSG00000103653" "CSK" "P41240; Q2M3N2; Q6FGZ6" "Integrin-mediated cell adhesion; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Phosphorylation of CD3 and TCR zeta chains; PD-1 signaling; Negative regulation of FLT3; GAB1 signalosome; Integrin signaling; RHOH GTPase cycle" "18" "0" "0.977" "1.035" "1.043" "1.020" "1.001" "1.044" "1.003" "0.969" "0.982" "1302.8" "1273.2" "1348.2" "1358.6" "1328.8" "1303.9" "1360.3" "1306.1" "1261.9" "1279.7" "" "" "" "" "" "" "" "" "" "" "1220.7" "1053.6" "1251.6" "1050.2" "1132.6" "1245.7" "1243.0" "1159.7" "1261.9" "1232.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-564768690041684779" "False" "High" "IsMasterProtein" "Q9H0L4" "Cleavage stimulation factor subunit 2 tau variant OS=Homo sapiens OX=9606 GN=CSTF2T PE=1 SV=1" "0.000" "False" "29.136" "20" "10" "15" "6" "616" "64.4" "7.25" "43.44" "10" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf14304, Pf14327" "23283" "ENSG00000177613" "CSTF2T" "B2RAR9; hsa:23283; O75174; Q53HK6; Q7LGE8; Q8N6T1; Q9H0L4" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "0.991" "0.997" "1.110" "1.090" "1.057" "1.155" "1.134" "1.138" "1.074" "644.6" "639.0" "643.0" "715.7" "702.6" "681.6" "744.3" "730.7" "733.3" "692.0" "" "" "" "" "" "" "" "" "" "" "604.0" "528.8" "596.9" "553.2" "598.8" "651.2" "680.1" "648.8" "733.3" "666.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5771737938610614120" "False" "High" "IsMasterProtein" "Q9UPN7" "Serine/threonine-protein phosphatase 6 regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PPP6R1 PE=1 SV=5" "0.000" "False" "29.094" "13" "10" "11" "10" "881" "96.7" "4.55" "35.54" "10" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf04499" "22870" "ENSG00000105063" "PPP6R1" "hsa:22870; Q2M2H3; Q504V2; Q6NVJ6; Q9BU97; Q9UPN7" "" "COPII-mediated vesicle transport" "1" "0" "0.986" "1.008" "1.001" "0.968" "0.992" "0.888" "0.837" "0.906" "0.943" "857.4" "845.1" "864.3" "858.0" "830.0" "850.2" "761.6" "718.0" "776.5" "808.6" "" "" "" "" "" "" "" "" "" "" "803.4" "699.3" "802.4" "663.2" "707.4" "812.3" "695.9" "637.5" "776.5" "778.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1723896581553543701" "False" "High" "IsMasterProtein" "Q07666" "KH domain-containing, RNA-binding, signal transduction-associated protein 1 OS=Homo sapiens OX=9606 GN=KHDRBS1 PE=1 SV=1" "0.000" "False" "29.094" "18" "10" "21" "10" "443" "48.2" "8.66" "56.70" "10" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf16274, Pf16568" "10657" "ENSG00000121774" "KHDRBS1" "D3DPP3; hsa:10657; Q07666; Q6PJX7; Q8NB97; Q99760" "Leptin signaling pathway; Primary ovarian insufficiency" "PTK6 Regulates Proteins Involved in RNA Processing" "3" "0" "1.039" "1.056" "1.056" "1.085" "1.078" "1.080" "1.136" "1.182" "1.078" "2086.2" "2167.2" "2202.8" "2203.7" "2264.2" "2249.1" "2252.9" "2370.2" "2465.7" "2248.7" "" "" "" "" "" "" "" "" "" "" "1954.7" "1793.3" "2045.0" "1703.6" "1930.0" "2148.8" "2058.6" "2104.5" "2465.7" "2165.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3180744532399736086" "False" "High" "IsMasterProtein" "Q15814" "Tubulin-specific chaperone C OS=Homo sapiens OX=9606 GN=TBCC PE=1 SV=2" "0.000" "False" "29.082" "25" "10" "15" "9" "346" "39.2" "5.71" "37.24" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf07986, Pf16752" "6903" "ENSG00000124659" "TBCC" "hsa:6903; Q15814; Q53Y43; Q5T787" "" "Post-chaperonin tubulin folding pathway" "1" "0" "1.039" "0.962" "1.031" "0.944" "0.969" "0.926" "0.914" "0.907" "0.966" "1453.9" "1510.5" "1398.6" "1499.4" "1372.3" "1408.1" "1346.7" "1329.4" "1318.8" "1404.3" "" "" "" "" "" "" "" "" "" "" "1362.3" "1249.9" "1298.4" "1159.1" "1169.7" "1345.3" "1230.5" "1180.4" "1318.8" "1352.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3142486401368971215" "False" "High" "IsMasterProtein" "Q3YEC7" "Rab-like protein 6 OS=Homo sapiens OX=9606 GN=RABL6 PE=1 SV=2" "0.000" "False" "29.049" "16" "10" "15" "10" "729" "79.5" "5.22" "50.13" "10" "" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08477" "55684" "ENSG00000196642" "RABL6" "A8QVZ7; A8QVZ8; C6K8I4; C6K8I5; hsa:55684; Q3YEC7; Q4F968; Q5T5R7; Q8IWK1; Q8TCL4; Q8WU94; Q96SR8; Q9BU21; Q9H935" "" "" "0" "0" "0.992" "0.987" "1.001" "1.030" "0.978" "0.989" "0.964" "0.959" "0.980" "1349.6" "1338.3" "1331.4" "1351.1" "1390.5" "1320.0" "1334.9" "1301.6" "1294.5" "1322.7" "" "" "" "" "" "" "" "" "" "" "1264.5" "1107.4" "1236.1" "1044.5" "1185.2" "1261.2" "1219.8" "1155.7" "1294.5" "1273.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3196973949191465790" "False" "High" "IsMasterProtein" "P07686" "Beta-hexosaminidase subunit beta OS=Homo sapiens OX=9606 GN=HEXB PE=1 SV=4" "0.000" "False" "29.043" "21" "12" "18" "11" "556" "63.1" "6.76" "44.24" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00728, Pf14845" "3074" "ENSG00000049860" "HEXB" "hsa:3074; P07686" "Glycosaminoglycan degradation" "Neutrophil degranulation; CS/DS degradation; Hyaluronan uptake and degradation; Glycosphingolipid catabolism; Keratan sulfate degradation; Defective HEXB causes GM2G2" "7" "1" "0.972" "0.976" "0.963" "0.966" "1.011" "0.941" "1.000" "0.969" "0.960" "2895.4" "2814.2" "2825.1" "2789.7" "2797.0" "2925.9" "2723.4" "2895.8" "2805.4" "2780.8" "" "" "" "" "" "" "" "" "" "" "2713.0" "2328.7" "2622.8" "2156.5" "2384.1" "2795.5" "2488.4" "2571.2" "2805.4" "2677.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7862445690525938863" "False" "High" "IsMasterProtein" "P32455" "Guanylate-binding protein 1 OS=Homo sapiens OX=9606 GN=GBP1 PE=1 SV=2" "0.000" "False" "29.042" "16" "10" "13" "9" "592" "67.9" "6.32" "37.60" "10" "cell organization and biogenesis;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf02263, Pf02841" "2633" "ENSG00000117228" "GBP1" "D3DT26; hsa:2633; P32455; Q5T8M1" "Type II interferon signaling" "Interferon gamma signaling" "2" "1" "0.924" "0.974" "0.943" "0.979" "0.955" "0.944" "0.974" "0.944" "0.979" "1755.7" "1621.5" "1709.7" "1655.3" "1718.7" "1677.2" "1657.6" "1710.8" "1656.7" "1719.5" "" "" "" "" "" "" "" "" "" "" "1645.1" "1341.7" "1587.2" "1279.6" "1465.0" "1602.4" "1514.6" "1519.1" "1656.7" "1655.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2429714834335380006" "False" "High" "IsMasterProtein" "P40818" "Ubiquitin carboxyl-terminal hydrolase 8 OS=Homo sapiens OX=9606 GN=USP8 PE=1 SV=1" "0.000" "False" "29.033" "10" "12" "13" "12" "1118" "127.4" "8.51" "31.10" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00443, Pf00581, Pf08969, Pf20625" "9101" "ENSG00000138592" "USP8" "B4DKA8; hsa:9101; P40818; Q2TB31; Q7Z3U2; Q86VA0; Q8IWI7" "EGF/EGFR signaling pathway; Male infertility" "Negative regulation of MET activity; Ub-specific processing proteases; Downregulation of ERBB2:ERBB3 signaling; Regulation of FZD by ubiquitination" "6" "0" "1.017" "0.982" "0.996" "1.042" "0.995" "1.012" "0.975" "0.983" "1.013" "1133.0" "1151.9" "1112.4" "1128.9" "1180.9" "1126.9" "1146.2" "1105.1" "1113.5" "1147.3" "" "" "" "" "" "" "" "" "" "" "1061.6" "953.2" "1032.7" "872.7" "1006.6" "1076.6" "1047.3" "981.2" "1113.5" "1104.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4094952149974440381" "False" "High" "IsMasterProtein" "Q9H3P2" "Negative elongation factor A OS=Homo sapiens OX=9606 GN=NELFA PE=1 SV=3" "0.000" "False" "29.017" "21" "8" "10" "8" "528" "57.2" "9.03" "40.09" "8" "other biological processes" "cytosol;nucleus" "other molecular function" "" "7469" "ENSG00000185049" "NELFA" "A2A2T1; hsa:7469; O95392; Q9H3P2" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; TP53 Regulates Transcription of DNA Repair Genes" "16" "0" "1.021" "1.042" "0.992" "1.045" "1.016" "0.993" "1.052" "1.024" "1.057" "1013.3" "1034.5" "1055.8" "1005.1" "1059.4" "1029.1" "1006.5" "1065.7" "1038.0" "1071.4" "" "" "" "" "" "" "" "" "" "" "949.4" "856.1" "980.2" "777.0" "903.0" "983.2" "919.7" "946.2" "1038.0" "1031.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-11749500110992675" "False" "High" "IsMasterProtein" "Q92995" "Ubiquitin carboxyl-terminal hydrolase 13 OS=Homo sapiens OX=9606 GN=USP13 PE=1 SV=2" "0.000" "False" "29.014" "12" "10" "12" "10" "863" "97.3" "5.53" "33.99" "10" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00443, Pf00627, Pf02148, Pf17807" "8975" "ENSG00000058056" "USP13" "A8K2S3; B4DYF3; D3DNS2; hsa:8975; Q92995; Q96B25" "" "Ub-specific processing proteases; Regulation of PTEN stability and activity" "2" "0" "1.013" "1.024" "1.036" "1.142" "1.073" "1.002" "0.954" "1.013" "1.074" "1324.3" "1340.9" "1355.9" "1371.8" "1512.3" "1421.5" "1327.2" "1263.9" "1341.4" "1422.2" "" "" "" "" "" "" "" "" "" "" "1240.9" "1109.6" "1258.8" "1060.5" "1289.0" "1358.1" "1212.7" "1122.2" "1341.4" "1369.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2604748441743257015" "False" "High" "IsMasterProtein" "Q6P1J9" "Parafibromin OS=Homo sapiens OX=9606 GN=CDC73 PE=1 SV=1" "0.000" "False" "28.994" "15" "9" "10" "9" "531" "60.5" "9.61" "34.58" "9" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf05179, Pf16050" "79577" "ENSG00000134371" "CDC73" "A6NLZ8; B2RBR2; hsa:79577; Q6P1J9; Q6PK51; Q96A07; Q9H245; Q9H5L7" "Endoderm differentiation" "Hedgehog 'on' state; RNA Polymerase II Pre-transcription Events; E3 ubiquitin ligases ubiquitinate target proteins; Formation of the beta-catenin:TCF transactivating complex; Formation of RNA Pol II elongation complex" "7" "0" "0.986" "0.992" "1.032" "1.039" "1.025" "1.043" "1.063" "1.029" "1.043" "1480.3" "1459.9" "1468.2" "1527.5" "1537.7" "1517.5" "1543.5" "1574.0" "1523.7" "1543.9" "" "" "" "" "" "" "" "" "" "" "1387.1" "1208.1" "1363.0" "1180.8" "1310.7" "1449.8" "1410.3" "1397.6" "1523.7" "1486.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518810540954697302" "False" "High" "IsMasterProtein" "Q8TAT6" "Nuclear protein localization protein 4 homolog OS=Homo sapiens OX=9606 GN=NPLOC4 PE=1 SV=3" "0.000" "False" "28.990" "16" "9" "9" "9" "608" "68.1" "6.38" "30.36" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf05020, Pf05021, Pf11543" "55666" "ENSG00000182446" "NPLOC4" "hsa:55666; Q8N3J1; Q8TAT6; Q9H8V2; Q9H964; Q9NWR5; Q9P229" "" "Neddylation; KEAP1-NFE2L2 pathway; Translesion Synthesis by POLH" "3" "0" "0.961" "0.964" "1.029" "0.938" "0.939" "0.944" "0.896" "0.933" "0.904" "1445.3" "1389.6" "1392.9" "1487.6" "1355.0" "1356.6" "1364.4" "1295.3" "1348.8" "1306.6" "" "" "" "" "" "" "" "" "" "" "1354.2" "1149.8" "1293.1" "1150.0" "1154.9" "1296.1" "1246.7" "1150.1" "1348.8" "1258.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1822360151641721881" "False" "High" "IsMasterProtein" "Q9NP81" "Serine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=SARS2 PE=1 SV=1" "0.000" "False" "28.989" "22" "10" "10" "10" "518" "58.2" "8.13" "32.39" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00587" "54938" "ENSG00000104835; ENSG00000283104" "SARS2" "A6NHW7; B4DE10; hsa:54938; Q9BVP3; Q9NP81" "Selenium metabolism and selenoproteins" "Mitochondrial tRNA aminoacylation" "2" "0" "0.972" "0.990" "1.002" "1.030" "1.041" "0.999" "1.057" "1.045" "1.028" "1284.7" "1249.1" "1272.4" "1286.9" "1323.2" "1337.2" "1283.7" "1358.0" "1341.8" "1320.7" "" "" "" "" "" "" "" "" "" "" "1203.7" "1033.6" "1181.3" "994.9" "1127.9" "1277.6" "1173.0" "1205.8" "1341.8" "1271.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1817111684576735415" "False" "High" "IsMasterProtein" "O15511" "Actin-related protein 2/3 complex subunit 5 OS=Homo sapiens OX=9606 GN=ARPC5 PE=1 SV=3" "0.000" "False" "28.971" "61" "7" "11" "7" "151" "16.3" "5.67" "46.72" "7" "cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf04699" "10092" "ENSG00000162704" "ARPC5" "A6NEC4; hsa:10092; O15511; Q6PG42" "Pathogenic Escherichia coli infection; Regulation of actin cytoskeleton" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "8" "0" "1.037" "0.966" "0.935" "0.978" "0.998" "0.935" "0.945" "0.925" "0.943" "1874.6" "1944.0" "1811.4" "1752.3" "1833.9" "1871.3" "1753.4" "1770.9" "1734.1" "1767.8" "" "" "" "" "" "" "" "" "" "" "1756.5" "1608.6" "1681.7" "1354.6" "1563.1" "1787.9" "1602.2" "1572.4" "1734.1" "1702.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2614245215378921803" "False" "High" "IsMasterProtein" "Q9UBU8" "Mortality factor 4-like protein 1 OS=Homo sapiens OX=9606 GN=MORF4L1 PE=1 SV=2" "0.000" "False" "28.894" "26" "8" "9" "6" "362" "41.4" "9.28" "31.65" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05712, Pf11717" "10933" "ENSG00000185787" "MORF4L1" "B4DKN6; B7Z6R1; D3DW88; hsa:10933; O95899; Q5QTS1; Q6NVX8; Q86YT7; Q9HBP6; Q9NSW5; Q9UBU8" "Pathways affected in adenoid cystic carcinoma" "HATs acetylate histones" "2" "1" "0.943" "0.953" "0.980" "0.974" "0.945" "1.019" "0.912" "0.952" "0.981" "763.5" "719.9" "727.5" "747.9" "743.4" "721.5" "778.4" "696.6" "726.9" "748.9" "" "" "" "" "" "" "" "" "" "" "715.4" "595.7" "675.4" "578.2" "633.7" "689.3" "711.2" "618.5" "726.9" "721.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2000149413272750326" "False" "High" "IsMasterProtein" "Q15907" "Ras-related protein Rab-11B OS=Homo sapiens OX=9606 GN=RAB11B PE=1 SV=4" "0.000" "False" "28.870" "40" "9" "12" "9" "218" "24.5" "5.94" "34.32" "9" "cell-cell signaling;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "9230" "ENSG00000185236" "RAB11B" "A5YM50; B2R7I4; B4DMK0; D6W671; hsa:9230; Q15907; Q2YDT2; Q5U0I1; Q6FHR0; Q6FI42; Q8NI07" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Intracellular trafficking proteins involved in CMT neuropathy; Vasopressin-regulated water reabsorption" "RAB geranylgeranylation; TBC/RABGAPs" "5" "0" "0.972" "1.032" "0.950" "0.933" "0.966" "0.910" "1.005" "0.989" "0.952" "1044.6" "1015.0" "1078.2" "992.1" "974.2" "1009.2" "950.1" "1049.8" "1033.3" "994.1" "" "" "" "" "" "" "" "" "" "" "978.8" "839.9" "1001.0" "767.0" "830.4" "964.2" "868.2" "932.1" "1033.3" "957.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4154359228263867930" "False" "High" "IsMasterProtein" "P46781" "Small ribosomal subunit protein uS4 OS=Homo sapiens OX=9606 GN=RPS9 PE=1 SV=3" "0.000" "False" "28.867" "42" "9" "12" "9" "194" "22.6" "10.65" "37.52" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00163, Pf01479" "6203" "ENSG00000170889; ENSG00000274005; ENSG00000274626; ENSG00000274646; ENSG00000274950; ENSG00000275323; ENSG00000277079; ENSG00000277359; ENSG00000278081; ENSG00000278270" "RPS9" "A9C4C1; hsa:6203; P46781; Q4QRK7; Q9BVZ0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "20" "0" "1.091" "1.059" "0.970" "1.002" "1.009" "1.165" "1.129" "1.070" "1.048" "883.7" "964.3" "935.5" "857.1" "885.9" "891.3" "1029.6" "997.8" "945.3" "926.5" "" "" "" "" "" "" "" "" "" "" "828.0" "798.0" "868.5" "662.6" "755.1" "851.6" "940.8" "886.0" "945.3" "892.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4617078502424805251" "False" "High" "IsMasterProtein" "Q9H857" "5'-nucleotidase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NT5DC2 PE=1 SV=1" "0.000" "False" "28.865" "17" "10" "11" "10" "520" "60.7" "6.77" "30.94" "10" "" "" "other molecular function" "Pf05761" "64943" "ENSG00000168268" "NT5DC2" "C9JTZ6; E9PAL9; hsa:64943; O95888; Q96C80; Q9H857; Q9H9Z8" "" "" "0" "0" "0.980" "1.041" "1.057" "1.068" "1.093" "1.010" "1.019" "1.026" "1.030" "1121.4" "1099.0" "1167.3" "1185.4" "1197.7" "1225.4" "1133.0" "1142.6" "1150.2" "1155.6" "" "" "" "" "" "" "" "" "" "" "1050.8" "909.4" "1083.7" "916.4" "1020.9" "1170.7" "1035.3" "1014.5" "1150.2" "1112.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2616426161905977358" "False" "High" "IsMasterProtein" "Q9UG63" "ATP-binding cassette sub-family F member 2 OS=Homo sapiens OX=9606 GN=ABCF2 PE=1 SV=2" "0.000" "False" "28.855" "18" "12" "16" "12" "623" "71.2" "7.37" "44.30" "12" "" "" "other molecular function" "Pf00005, Pf12848" "10061; 114483834" "ENSG00000033050" "ABCF2" "hsa:10061; hsa:114483834; O60864; Q75MJ0; Q75MJ1; Q96TE8; Q9UG63" "VEGFA-VEGFR2 signaling" "NFE2L2 regulating MDR associated enzymes" "2" "0" "0.997" "0.983" "1.001" "1.098" "1.079" "1.056" "1.077" "1.132" "1.028" "2470.5" "2462.9" "2428.3" "2472.6" "2713.2" "2666.5" "2610.1" "2660.1" "2797.3" "2539.5" "" "" "" "" "" "" "" "" "" "" "2314.9" "2038.0" "2254.3" "1911.4" "2312.6" "2547.6" "2384.9" "2361.9" "2797.3" "2445.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2136811018986940550" "False" "High" "IsMasterProtein" "Q9NS91" "E3 ubiquitin-protein ligase RAD18 OS=Homo sapiens OX=9606 GN=RAD18 PE=1 SV=2" "0.000" "False" "28.825" "20" "10" "11" "10" "495" "56.2" "7.58" "34.35" "10" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf13923" "56852" "ENSG00000070950" "RAD18" "Q58F55; Q9NRT6; Q9NS91" "SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome" "Recognition of DNA damage by PCNA-containing replication complex; E3 ubiquitin ligases ubiquitinate target proteins" "3" "0" "0.986" "0.979" "1.015" "1.003" "0.991" "0.975" "0.969" "0.917" "0.973" "1227.4" "1210.1" "1201.9" "1245.2" "1231.2" "1216.1" "1196.8" "1189.5" "1125.2" "1194.7" "" "" "" "" "" "" "" "" "" "" "1150.1" "1001.4" "1115.8" "962.6" "1049.5" "1161.9" "1093.5" "1056.1" "1125.2" "1150.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5055182102876441761" "False" "High" "IsMasterProtein" "Q9BRT9" "DNA replication complex GINS protein SLD5 OS=Homo sapiens OX=9606 GN=GINS4 PE=1 SV=1" "0.000" "False" "28.813" "39" "8" "16" "8" "223" "26.0" "4.98" "44.56" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes" "nucleus;other cell component" "" "Pf05916, Pf16922" "84296" "ENSG00000147536" "GINS4" "B2R8H5; D3DSY0; hsa:84296; Q8N648; Q9BRT9" "" "Unwinding of DNA" "1" "0" "1.084" "1.061" "1.060" "1.141" "1.158" "1.022" "1.109" "1.150" "1.070" "1264.7" "1371.0" "1342.1" "1340.8" "1443.0" "1464.7" "1292.1" "1402.9" "1454.3" "1353.3" "" "" "" "" "" "" "" "" "" "" "1185.0" "1134.4" "1246.0" "1036.5" "1230.0" "1399.4" "1180.6" "1245.6" "1454.3" "1303.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6960359147395003723" "False" "High" "IsMasterProtein" "P15498" "Proto-oncogene vav OS=Homo sapiens OX=9606 GN=VAV1 PE=1 SV=4" "0.000" "False" "28.803" "11" "10" "12" "10" "845" "98.3" "6.62" "32.25" "10" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00017, Pf00018, Pf00130, Pf00169, Pf00307, Pf00621" "7409" "ENSG00000141968" "VAV1" "B4DVK9; hsa:7409; M0QXX6; P15498; Q15860" "Prolactin signaling pathway; B cell receptor signaling pathway; Hematopoietic stem cell differentiation; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL6 signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; EGF/EGFR signaling pathway; Modulators of TCR signaling and T cell activation; Regulation of actin cytoskeleton; Interferon type I signaling pathways; T-cell receptor signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; RHOA GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; Signaling by SCF-KIT; Azathioprine ADME; VEGFR2 mediated vascular permeability; Erythropoietin activates RAS; CD28 dependent Vav1 pathway" "38" "0" "0.941" "0.962" "0.950" "0.968" "0.980" "0.874" "0.875" "0.931" "0.969" "1009.3" "949.4" "971.2" "959.3" "977.0" "989.2" "882.6" "882.9" "939.6" "977.8" "" "" "" "" "" "" "" "" "" "" "945.7" "785.6" "901.6" "741.6" "832.8" "945.1" "806.4" "783.9" "939.6" "941.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2599348248423270713" "False" "High" "IsMasterProtein" "P23258" "Tubulin gamma-1 chain OS=Homo sapiens OX=9606 GN=TUBG1 PE=1 SV=2" "0.000" "False" "28.764" "24" "10" "17" "10" "451" "51.1" "6.14" "47.66" "10" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7283" "ENSG00000131462" "TUBG1" "hsa:7283; P23258; Q53X79; Q9BW59" "Alstrom syndrome" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "8" "0" "1.042" "1.048" "1.058" "1.040" "1.052" "0.987" "0.979" "0.996" "1.029" "879.9" "917.2" "922.4" "931.0" "915.5" "925.7" "868.8" "861.4" "876.2" "905.5" "" "" "" "" "" "" "" "" "" "" "824.5" "759.0" "856.4" "719.7" "780.4" "884.4" "793.8" "764.8" "876.2" "871.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2106198041571123129" "False" "High" "IsMasterProtein" "Q9UMS4" "Pre-mRNA-processing factor 19 OS=Homo sapiens OX=9606 GN=PRPF19 PE=1 SV=1" "0.000" "False" "28.756" "22" "9" "17" "9" "504" "55.1" "6.61" "52.96" "9" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400, Pf04564, Pf08606" "27339" "ENSG00000110107" "PRPF19" "Q9UMS4" "" "Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex" "5" "0" "0.952" "1.020" "0.969" "1.000" "1.012" "1.108" "1.155" "1.118" "1.058" "1908.7" "1816.7" "1947.6" "1850.4" "1907.8" "1931.6" "2114.1" "2204.1" "2133.6" "2018.7" "" "" "" "" "" "" "" "" "" "" "1788.4" "1503.3" "1808.1" "1430.5" "1626.2" "1845.5" "1931.7" "1957.0" "2133.6" "1943.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2637590011477773491" "False" "High" "IsMasterProtein" "P46459" "Vesicle-fusing ATPase OS=Homo sapiens OX=9606 GN=NSF PE=1 SV=3" "0.000" "False" "28.754" "15" "12" "15" "12" "744" "82.5" "6.95" "33.50" "12" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00004, Pf02359, Pf02933, Pf17862" "4905" "ENSG00000073969; ENSG00000276262; ENSG00000278174" "NSF" "A8K2D9; B4DFA2; P46459; Q8N6D7; Q9UKZ2" "Synaptic vesicle pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Vasopressin-regulated water reabsorption" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; Retrograde transport at the Trans-Golgi-Network; Trafficking of GluR2-containing AMPA receptors" "9" "0" "1.091" "1.048" "1.119" "1.104" "1.079" "2.103" "1.173" "1.184" "1.070" "592.1" "646.1" "620.6" "662.5" "653.6" "638.6" "1244.9" "694.2" "701.2" "633.3" "" "" "" "" "" "" "" "" "" "" "554.8" "534.7" "576.1" "512.1" "557.1" "610.1" "1137.5" "616.4" "701.2" "609.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7347727386660618652" "False" "High" "IsMasterProtein" "Q8IUI8" "Cytokine receptor-like factor 3 OS=Homo sapiens OX=9606 GN=CRLF3 PE=1 SV=2" "0.000" "False" "28.754" "21" "8" "8" "8" "442" "49.7" "5.14" "31.78" "8" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "51379" "ENSG00000176390" "CRLF3" "A6NJF3; B2R8C3; hsa:51379; Q2MLY7; Q8IUI8; Q9UNI3; Q9Y6M8" "NF1 copy number variation syndrome" "" "1" "0" "0.982" "1.002" "1.039" "1.002" "0.953" "0.988" "1.026" "0.941" "1.001" "1086.2" "1067.1" "1088.4" "1128.9" "1088.3" "1035.6" "1073.5" "1114.4" "1022.0" "1086.9" "" "" "" "" "" "" "" "" "" "" "1017.7" "883.0" "1010.5" "872.7" "927.6" "989.4" "980.9" "989.5" "1022.0" "1046.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6548479852001098502" "False" "High" "IsMasterProtein" "P10253" "Lysosomal alpha-glucosidase OS=Homo sapiens OX=9606 GN=GAA PE=1 SV=4" "0.000" "False" "28.732" "12" "10" "15" "10" "952" "105.3" "6.00" "40.00" "10" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00088, Pf01055, Pf13802, Pf21365" "2548" "ENSG00000171298; ENSG00000291507" "GAA" "hsa:2548; P10253; Q09GN4; Q14351; Q16302; Q8IWE7" "" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis); Glycogen storage disease type II (GAA)" "3" "0" "1.007" "1.002" "1.074" "1.064" "1.020" "1.024" "1.026" "1.037" "1.063" "1373.0" "1382.2" "1375.3" "1475.3" "1460.4" "1400.5" "1405.7" "1408.9" "1424.5" "1460.1" "" "" "" "" "" "" "" "" "" "" "1286.5" "1143.8" "1276.8" "1140.4" "1244.8" "1338.1" "1284.4" "1251.0" "1424.5" "1405.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4481377694352566724" "False" "High" "IsMasterProtein" "P15121" "Aldo-keto reductase family 1 member B1 OS=Homo sapiens OX=9606 GN=AKR1B1 PE=1 SV=3" "0.000" "False" "28.714" "25" "8" "15" "7" "316" "35.8" "6.98" "47.89" "8" "other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus" "other molecular function" "Pf00248" "231" "ENSG00000085662" "AKR1B1" "B2R8N3; hsa:231; P15121; Q5U031; Q6FGA4; Q6ICP2; Q9BS21; Q9UCI9" "Eicosanoid metabolism via cyclooxygenases (COX); Disorders of galactose metabolism ; Omega-6-fatty acids in senescence; Polyol pathway; Metapathway biotransformation Phase I and II" "Pregnenolone biosynthesis; Fructose biosynthesis" "7" "0" "0.929" "0.966" "0.931" "0.909" "0.923" "0.879" "0.903" "0.937" "0.918" "2041.7" "1897.1" "1971.6" "1901.2" "1855.6" "1883.8" "1794.1" "1842.7" "1913.3" "1874.7" "" "" "" "" "" "" "" "" "" "" "1913.1" "1569.8" "1830.4" "1469.7" "1581.7" "1799.8" "1639.4" "1636.1" "1913.3" "1805.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6049594169438393906" "False" "High" "IsMasterProtein" "Q52LJ0" "Protein FAM98B OS=Homo sapiens OX=9606 GN=FAM98B PE=1 SV=2" "0.000" "False" "28.707" "21" "7" "10" "6" "433" "45.5" "8.69" "34.88" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10239" "283742" "ENSG00000171262" "FAM98B" "A8MUW5; hsa:283742; Q52LJ0; Q8N935" "" "tRNA processing in the nucleus" "1" "0" "1.024" "1.089" "1.026" "1.113" "1.090" "1.050" "1.057" "1.050" "1.091" "633.1" "648.2" "689.6" "649.7" "704.5" "690.0" "664.6" "669.4" "664.6" "690.6" "" "" "" "" "" "" "" "" "" "" "593.2" "536.4" "640.2" "502.2" "600.5" "659.2" "607.2" "594.4" "664.6" "665.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4758086446517534587" "False" "High" "IsMasterProtein" "P62316" "Small nuclear ribonucleoprotein Sm D2 OS=Homo sapiens OX=9606 GN=SNRPD2 PE=1 SV=1" "0.000" "False" "28.673" "62" "7" "15" "7" "118" "13.5" "9.91" "44.65" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6633" "ENSG00000125743" "SNRPD2" "A8K797; hsa:6633; J3KPM5; P43330; P62316" "mRNA processing" "mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; snRNP Assembly; mRNA Splicing - Minor Pathway" "5" "0" "1.096" "1.096" "1.064" "1.045" "1.041" "1.078" "1.077" "1.077" "1.046" "685.7" "751.2" "751.6" "729.9" "716.4" "713.9" "739.3" "738.7" "738.6" "717.1" "" "" "" "" "" "" "" "" "" "" "642.5" "621.6" "697.8" "564.2" "610.7" "682.1" "675.5" "655.9" "738.6" "690.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3957617844882623254" "False" "High" "IsMasterProtein" "Q7Z3B4" "Nucleoporin p54 OS=Homo sapiens OX=9606 GN=NUP54 PE=1 SV=2" "0.000" "False" "28.622" "20" "10" "15" "10" "507" "55.4" "7.02" "44.64" "10" "cell organization and biogenesis;transport;other biological processes" "other membranes;nucleus" "other molecular function" "Pf13874, Pf18437" "53371" "ENSG00000138750" "NUP54" "B2RCK7; B4DT35; hsa:53371; Q7Z3B4; Q96EA7; Q9NVL5; Q9P0I1" "" "HCMV Early Events; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "0.996" "0.985" "0.957" "0.986" "1.067" "1.077" "0.968" "1.049" "1.043" "1275.0" "1270.0" "1255.9" "1220.4" "1257.2" "1359.9" "1372.9" "1233.6" "1337.3" "1329.4" "" "" "" "" "" "" "" "" "" "" "1194.7" "1050.9" "1165.9" "943.4" "1071.6" "1299.2" "1254.5" "1095.3" "1337.3" "1280.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5396921561883894054" "False" "High" "IsMasterProtein" "Q96GD0" "Chronophin OS=Homo sapiens OX=9606 GN=PDXP PE=1 SV=2" "0.000" "False" "28.589" "37" "8" "8" "8" "296" "31.7" "6.55" "29.25" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf13242, Pf13344" "57026" "ENSG00000241360" "PDXP" "hsa:57026; Q96GD0; Q9UGY2" "" "" "0" "0" "1.075" "0.951" "1.187" "1.028" "1.051" "1.133" "1.028" "1.027" "1.021" "522.5" "561.6" "496.6" "620.3" "537.3" "549.1" "591.8" "537.1" "536.5" "533.6" "" "" "" "" "" "" "" "" "" "" "489.5" "464.8" "461.1" "479.6" "458.0" "524.6" "540.8" "476.9" "536.5" "513.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7915311945115274700" "False" "High" "IsMasterProtein" "O15212" "Prefoldin subunit 6 OS=Homo sapiens OX=9606 GN=PFDN6 PE=1 SV=1" "0.000" "False" "28.588" "49" "7" "11" "7" "129" "14.6" "8.88" "40.51" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "10471" "ENSG00000204220; ENSG00000206283; ENSG00000224782; ENSG00000235692; ENSG00000237335" "PFDN6" "hsa:10471; O15212" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "1.061" "1.026" "1.036" "1.078" "0.984" "1.028" "1.042" "0.949" "0.999" "974.2" "1033.6" "999.1" "1009.4" "1050.1" "958.8" "1001.8" "1014.9" "924.8" "972.7" "" "" "" "" "" "" "" "" "" "" "912.8" "855.3" "927.5" "780.3" "895.1" "916.1" "915.3" "901.2" "924.8" "936.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "124053754926249858" "False" "High" "IsMasterProtein" "Q9UBF2" "Coatomer subunit gamma-2 OS=Homo sapiens OX=9606 GN=COPG2 PE=1 SV=1" "0.000" "False" "28.560" "10" "9" "12" "8" "871" "97.6" "5.81" "39.43" "9" "transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01602, Pf08752, Pf16381" "26958" "ENSG00000158623" "COPG2" "A6NH74; hsa:26958; Q2NLA0; Q54AC3; Q8WVW8; Q9UBF2" "" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic" "2" "0" "0.921" "0.986" "0.921" "0.956" "1.013" "0.926" "0.913" "0.959" "0.974" "2454.2" "2260.4" "2419.8" "2260.0" "2346.2" "2484.9" "2273.4" "2240.8" "2354.3" "2389.7" "" "" "" "" "" "" "" "" "" "" "2299.6" "1870.4" "2246.4" "1747.1" "1999.8" "2374.1" "2077.2" "1989.6" "2354.3" "2300.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5820221568948669859" "False" "High" "IsMasterProtein" "P61081" "NEDD8-conjugating enzyme Ubc12 OS=Homo sapiens OX=9606 GN=UBE2M PE=1 SV=1" "0.000" "False" "28.558" "45" "8" "11" "8" "183" "20.9" "7.69" "34.32" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "9040" "ENSG00000130725" "UBE2M" "hsa:9040; O76069; P61081; Q8VC50" "" "Antigen processing: Ubiquitination & Proteasome degradation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Neddylation; TGF-beta receptor signaling activates SMADs" "5" "0" "0.952" "0.989" "0.955" "0.980" "1.012" "0.930" "0.944" "1.013" "0.993" "1411.0" "1343.6" "1395.1" "1347.6" "1382.5" "1428.1" "1312.0" "1332.7" "1428.9" "1401.3" "" "" "" "" "" "" "" "" "" "" "1322.1" "1111.8" "1295.2" "1041.8" "1178.4" "1364.4" "1198.8" "1183.3" "1428.9" "1349.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "185652229165611282" "False" "High" "IsMasterProtein" "Q9NY27" "Serine/threonine-protein phosphatase 4 regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PPP4R2 PE=1 SV=3" "0.000" "False" "28.548" "36" "9" "11" "9" "417" "46.9" "4.54" "44.94" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf09184" "151987" "ENSG00000163605" "PPP4R2" "A8K1I6; hsa:151987; Q2TAJ9; Q498B8; Q8WXX6; Q9NY27" "16p11.2 proximal deletion syndrome" "Processing of DNA double-strand break ends" "2" "0" "0.984" "0.993" "0.998" "1.038" "0.981" "0.981" "1.011" "0.993" "1.025" "606.6" "596.7" "602.1" "605.7" "629.5" "595.3" "595.4" "613.6" "602.6" "621.7" "" "" "" "" "" "" "" "" "" "" "568.4" "493.8" "559.0" "468.2" "536.6" "568.7" "544.1" "544.8" "602.6" "598.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4253585410806837271" "False" "High" "IsMasterProtein" "Q8TEU7" "Rap guanine nucleotide exchange factor 6 OS=Homo sapiens OX=9606 GN=RAPGEF6 PE=1 SV=2" "0.000" "False" "28.527" "6" "12" "14" "11" "1601" "179.3" "6.40" "36.76" "12" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf00595, Pf00617, Pf00618, Pf00788" "51735" "ENSG00000158987" "RAPGEF6" "A3KN82; A5PLL6; B7ZML2; E9PDV7; hsa:51735; Q8NI21; Q8TEU6; Q8TEU7; Q96PC1" "" "" "0" "0" "1.022" "1.009" "1.017" "1.012" "1.023" "1.001" "0.927" "0.932" "0.985" "981.7" "1002.8" "990.5" "997.9" "993.8" "1004.5" "982.7" "909.6" "914.6" "967.2" "" "" "" "" "" "" "" "" "" "" "919.8" "829.8" "919.5" "771.4" "847.0" "959.7" "897.9" "807.6" "914.6" "931.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5859818642723021868" "False" "High" "IsMasterProtein" "Q96RS6" "NudC domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NUDCD1 PE=1 SV=2" "0.000" "False" "28.508" "18" "9" "11" "9" "583" "66.7" "5.11" "37.24" "9" "other biological processes" "cytosol;nucleus" "" "Pf04969" "84955" "ENSG00000120526" "NUDCD1" "B4DVX6; hsa:84955; Q4G130; Q8NDQ5; Q8NG18; Q96RS6; Q96SI4; Q9BVR5" "" "" "0" "0" "0.995" "1.038" "1.018" "1.050" "1.019" "0.985" "0.991" "1.042" "1.049" "1127.9" "1122.3" "1171.2" "1148.1" "1184.0" "1148.9" "1110.5" "1117.9" "1175.7" "1183.4" "" "" "" "" "" "" "" "" "" "" "1056.9" "928.7" "1087.3" "887.5" "1009.2" "1097.7" "1014.7" "992.6" "1175.7" "1139.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2951553745667677229" "False" "High" "IsMasterProtein" "P31689" "DnaJ homolog subfamily A member 1 OS=Homo sapiens OX=9606 GN=DNAJA1 PE=1 SV=2" "0.000" "False" "28.504" "28" "9" "14" "9" "397" "44.8" "7.08" "44.65" "9" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00226, Pf00684, Pf01556" "3301" "ENSG00000086061" "DNAJA1" "hsa:3301; P31689; Q5T7Q0; Q86TL9" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation; HDAC6 interactions in the central nervous system" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "4" "0" "1.014" "1.026" "0.962" "0.933" "0.997" "0.907" "0.904" "0.928" "0.960" "2528.3" "2563.3" "2593.1" "2432.1" "2358.4" "2521.1" "2294.1" "2285.7" "2345.9" "2426.9" "" "" "" "" "" "" "" "" "" "" "2369.0" "2121.1" "2407.4" "1880.2" "2010.3" "2408.7" "2096.2" "2029.4" "2345.9" "2336.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8252267867784187079" "False" "High" "IsMasterProtein" "Q86YP4" "Transcriptional repressor p66-alpha OS=Homo sapiens OX=9606 GN=GATAD2A PE=1 SV=1" "0.000" "False" "28.493" "19" "10" "11" "10" "633" "68.0" "9.94" "33.95" "10" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00320, Pf16563" "54815" "ENSG00000167491" "GATAD2A" "B5MC40; hsa:54815; Q7L3J2; Q86YP4; Q96F28; Q9NPU2; Q9NXS1" "" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "6" "0" "1.108" "1.048" "1.096" "1.083" "1.042" "1.033" "1.028" "1.070" "1.106" "861.0" "953.6" "902.6" "943.7" "932.3" "896.8" "889.4" "884.9" "920.9" "952.6" "" "" "" "" "" "" "" "" "" "" "806.8" "789.1" "838.0" "729.6" "794.7" "856.8" "812.6" "785.7" "920.9" "917.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6934522081491213014" "False" "High" "IsMasterProtein" "P11908" "Ribose-phosphate pyrophosphokinase 2 OS=Homo sapiens OX=9606 GN=PRPS2 PE=1 SV=2" "0.000" "False" "28.469" "33" "10" "13" "4" "318" "34.7" "6.61" "49.75" "10" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf13793, Pf14572" "5634" "ENSG00000101911" "PRPS2" "hsa:5634; P11908; Q0VDH9; Q0VDI0; Q15245; Q2TAK7" "" "5-Phosphoribose 1-diphosphate biosynthesis" "1" "0" "0.859" "0.917" "0.925" "0.945" "0.847" "0.893" "0.903" "0.924" "0.853" "536.9" "461.2" "492.6" "496.9" "507.4" "454.7" "479.7" "484.7" "496.2" "458.2" "" "" "" "" "" "" "" "" "" "" "503.1" "381.6" "457.3" "384.1" "432.5" "434.4" "438.3" "430.4" "496.2" "441.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3718906404474103384" "False" "High" "IsMasterProtein" "P19174" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Homo sapiens OX=9606 GN=PLCG1 PE=1 SV=1" "0.000" "False" "28.462" "8" "11" "11" "11" "1290" "148.4" "6.05" "34.50" "11" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018, Pf00168, Pf00169, Pf00387, Pf00388" "5335" "ENSG00000124181" "PLCG1" "B7ZLY7; B9EGH4; E1P5W4; hsa:5335; P19174; Q2V575" "Angiogenesis; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; PDGF pathway; Primary focal segmental glomerulosclerosis (FSGS); T cell receptor and co-stimulatory signaling; Myometrial relaxation and contraction pathways; Kit receptor signaling pathway; MFAP5-mediated ovarian cancer cell motility and invasiveness; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; GPR40 pathway; PDGFR-beta pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling; Non-small cell lung cancer; EGF/EGFR signaling pathway; Resistin as a regulator of inflammation; Fragile X syndrome; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; mBDNF and proBDNF regulation of GABA neurotransmission; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis; GDNF signaling; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; ErbB signaling pathway; T-cell receptor signaling pathway" "ISG15 antiviral mechanism; Role of phospholipids in phagocytosis; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Generation of second messenger molecules; Signaling by ALK fusions and activated point mutants; RET signaling; Downstream signal transduction; Signaling by ALK; DAP12 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; EGFR interacts with phospholipase C-gamma; Signaling by FGFR1 in disease; Synthesis of IP3 and IP4 in the cytosol; Phospholipase C-mediated cascade: FGFR1; Phospholipase C-mediated cascade; FGFR2; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Phospholipase C-mediated cascade; FGFR3; Phospholipase C-mediated cascade; FGFR4; Signaling by FGFR3 in disease; DAG and IP3 signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Role of second messengers in netrin-1 signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; PLCG1 events in ERBB2 signaling; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; PLC-gamma1 signalling; PECAM1 interactions; Activated NTRK2 signals through PLCG1; Activated NTRK3 signals through PLCG1" "76" "0" "1.009" "1.015" "1.071" "1.013" "1.044" "0.982" "1.003" "1.005" "1.010" "1122.5" "1132.1" "1138.8" "1202.2" "1136.6" "1171.6" "1102.0" "1126.1" "1128.6" "1133.7" "" "" "" "" "" "" "" "" "" "" "1051.8" "936.8" "1057.2" "929.3" "968.8" "1119.3" "1006.9" "999.9" "1128.6" "1091.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4752916691292977805" "False" "High" "IsMasterProtein" "Q15057" "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ACAP2 PE=1 SV=3" "0.000" "False" "28.434" "13" "10" "13" "10" "778" "88.0" "6.80" "39.65" "10" "transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01412, Pf12796, Pf16746" "23527" "ENSG00000114331" "ACAP2" "A8K2V4; hsa:23527; Q15057; Q8N5Z8; Q9UQR3" "" "" "0" "0" "0.945" "0.953" "0.987" "0.944" "0.958" "0.913" "0.965" "0.909" "0.947" "1901.1" "1796.9" "1811.9" "1877.0" "1794.5" "1820.6" "1735.9" "1834.5" "1728.1" "1800.9" "" "" "" "" "" "" "" "" "" "" "1781.4" "1486.9" "1682.1" "1451.0" "1529.6" "1739.4" "1586.1" "1628.8" "1728.1" "1734.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3397920079809031089" "False" "High" "IsMasterProtein" "Q7Z5R6" "Amyloid beta A4 precursor protein-binding family B member 1-interacting protein OS=Homo sapiens OX=9606 GN=APBB1IP PE=1 SV=1" "0.000" "False" "28.414" "17" "9" "15" "9" "666" "73.1" "5.59" "49.12" "9" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "" "Pf00169, Pf00788" "54518" "ENSG00000077420" "APBB1IP" "hsa:54518; Q7Z5R6; Q8IWS8; Q8IYL7; Q8IZZ7" "TYROBP causal network in microglia" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins" "11" "0" "0.920" "1.064" "0.892" "0.937" "1.028" "0.890" "0.977" "1.033" "1.003" "1162.8" "1069.5" "1237.4" "1037.0" "1089.4" "1195.9" "1034.7" "1135.9" "1200.7" "1166.0" "" "" "" "" "" "" "" "" "" "" "1089.6" "885.0" "1148.8" "801.6" "928.6" "1142.6" "945.4" "1008.6" "1200.7" "1122.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3992202401745413050" "False" "High" "IsMasterProtein" "O75044" "SLIT-ROBO Rho GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=SRGAP2 PE=1 SV=3" "0.000" "False" "28.412" "9" "11" "12" "11" "1071" "120.8" "6.70" "34.67" "11" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00611, Pf00620" "23380" "ENSG00000266028" "SRGAP2" "A2RUF3; hsa:23380; O75044" "" "RHO GTPases Activate Formins; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC3 GTPase cycle; RHOF GTPase cycle; RHOU GTPase cycle; Inactivation of CDC42 and RAC1" "8" "0" "1.047" "1.041" "1.074" "1.086" "1.118" "1.126" "1.149" "1.161" "1.080" "1018.8" "1066.9" "1061.0" "1094.5" "1106.9" "1139.0" "1147.3" "1170.5" "1183.3" "1100.8" "" "" "" "" "" "" "" "" "" "" "954.6" "882.8" "985.0" "846.1" "943.5" "1088.2" "1048.4" "1039.3" "1183.3" "1059.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8207864549745438201" "False" "High" "IsMasterProtein" "Q96T76" "MMS19 nucleotide excision repair protein homolog OS=Homo sapiens OX=9606 GN=MMS19 PE=1 SV=2" "0.000" "False" "28.383" "9" "9" "11" "9" "1030" "113.2" "6.35" "36.41" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf12460, Pf14500" "64210" "ENSG00000155229" "MMS19" "B0QZ75; B3KPE5; B4DQX2; B4E2I3; D3DR55; F8W9Y2; hsa:64210; Q17RZ8; Q5T455; Q66K82; Q7L4W8; Q969Z1; Q96DF1; Q96MR1; Q96RK5; Q96SK1; Q96T76; Q9BUE2; Q9BYS9" "2q11.2 copy number variation syndrome" "Cytosolic iron-sulfur cluster assembly" "2" "0" "1.012" "1.015" "1.040" "1.045" "0.983" "0.993" "0.970" "0.999" "1.028" "1054.8" "1067.9" "1070.7" "1096.5" "1102.7" "1036.7" "1047.1" "1022.6" "1054.2" "1084.4" "" "" "" "" "" "" "" "" "" "" "988.3" "883.7" "994.1" "847.7" "939.9" "990.5" "956.7" "908.0" "1054.2" "1044.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8603846715658809849" "False" "High" "IsMasterProtein" "Q14807" "Kinesin-like protein KIF22 OS=Homo sapiens OX=9606 GN=KIF22 PE=1 SV=5" "0.000" "False" "28.377" "14" "9" "10" "9" "665" "73.2" "9.45" "26.93" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00225, Pf12836" "3835" "ENSG00000079616" "KIF22" "B2R5M0; B7Z265; hsa:3835; O60845; O94814; Q14807; Q53F58; Q9BT46" "16p11.2 proximal deletion syndrome" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins" "4" "0" "1.183" "1.046" "1.289" "1.158" "1.162" "1.173" "1.186" "1.158" "1.131" "852.0" "1007.7" "891.6" "1098.6" "986.7" "990.0" "999.7" "1010.6" "986.5" "963.4" "" "" "" "" "" "" "" "" "" "" "798.3" "833.9" "827.7" "849.2" "841.1" "945.8" "913.5" "897.3" "986.5" "927.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3193827358447086587" "False" "High" "IsMasterProtein" "P20936" "Ras GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RASA1 PE=1 SV=1" "0.000" "False" "28.374" "8" "8" "9" "8" "1047" "116.3" "6.54" "29.72" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018, Pf00168, Pf00169, Pf00616" "5921" "ENSG00000145715" "RASA1" "B2R6W3; B4DTL2; hsa:5921; P20936; Q68CU6; Q9UDI1" "Androgen receptor network in prostate cancer; PDGF pathway; T cell receptor and co-stimulatory signaling; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; PDGFR-beta pathway; Ras signaling; Acute viral myocarditis; EGF/EGFR signaling pathway; GDNF signaling; EPO receptor signaling" "Regulation of RAS by GAPs; EPHB-mediated forward signaling; Downstream signal transduction; VEGFR2 mediated cell proliferation; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases" "17" "0" "1.021" "1.039" "1.051" "1.095" "1.064" "0.996" "1.054" "0.997" "1.099" "528.7" "539.7" "549.1" "555.9" "579.2" "562.8" "526.6" "557.2" "527.4" "581.0" "" "" "" "" "" "" "" "" "" "" "495.4" "446.6" "509.8" "429.7" "493.7" "537.7" "481.1" "494.7" "527.4" "559.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3062212909163771863" "False" "High" "IsMasterProtein" "P19838" "Nuclear factor NF-kappa-B p105 subunit OS=Homo sapiens OX=9606 GN=NFKB1 PE=1 SV=2" "0.000" "False" "28.312" "9" "9" "12" "9" "968" "105.3" "5.40" "39.47" "9" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00023, Pf00531, Pf00554, Pf16179" "4790" "ENSG00000109320" "NFKB1" "A8K5Y5; B3KVE8; hsa:4790; P19838; Q68D84; Q86V43; Q8N4X7; Q9NZC0" "Osteopontin signaling; Selenium micronutrient network; Vitamin B12 metabolism; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Folate metabolism; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; PDGF pathway; Apoptosis; T cell receptor and co-stimulatory signaling; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Selenium metabolism and selenoproteins; Apoptosis-related network due to altered Notch3 in ovarian cancer; IL1 and megakaryocytes in obesity; Myometrial relaxation and contraction pathways; Melatonin metabolism and effects; RAC1/PAK1/p38/MMP2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Photodynamic therapy-induced NF-kB survival signaling; NAD metabolism, sirtuins and aging; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; MYD88 distinct input-output pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Oxidative damage response; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; Prion disease pathway; NO/cGMP/PKG mediated neuroprotection; Oxidative stress response; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Non-genomic actions of 1,25 dihydroxyvitamin D3; Ciliary landscape; Nonalcoholic fatty liver disease; LTF danger signal response pathway; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Canonical NF-kB pathway; Cancer immunotherapy by PD-1 blockade; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Aspirin and miRNAs; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; FGF23 signaling in hypophosphatemic rickets and related disorders; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; Activation of NLRP3 inflammasome by SARS-CoV-2; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; STING pathway in Kawasaki-like disease and COVID-19; RAS and bradykinin pathways in COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Prostaglandin signaling; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Inclusion body myositis; Alzheimer's disease; Th17 cell differentiation pathway; Lung pathology of COVID-19; Ulcerative colitis signaling; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Inflammatory bowel disease signaling; Role of ROS in COVID-19 endothelial dysfunction; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; TROP2 regulatory signaling; Autophagy in pancreatic ductal adenocarcinoma; Macrophage-stimulating protein (MSP) signaling network map; Affected pathways in Duchenne muscular dystrophy; TAR syndrome; Osteoarthritic chondrocyte hypertrophy; 10q22q23 copy number variation; IL-19 signaling pathway; GNAQ pathways in port-wine stain; TGF-beta receptor signaling; Notch signaling pathway; T-cell receptor signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; RIP-mediated NFkB activation via ZBP1; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; Neutrophil degranulation; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; PKMTs methylate histone lysines; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; Regulation of NFE2L2 gene expression; CD209 (DC-SIGN) signaling; Interleukin-1 processing; CLEC7A/inflammasome pathway; Regulated proteolysis of p75NTR; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "151" "0" "1.015" "1.029" "1.032" "1.014" "1.051" "1.000" "0.993" "1.025" "1.098" "1037.9" "1053.5" "1067.7" "1071.3" "1052.6" "1090.5" "1037.7" "1031.0" "1063.6" "1139.4" "" "" "" "" "" "" "" "" "" "" "972.5" "871.8" "991.3" "828.1" "897.2" "1041.9" "948.2" "915.4" "1063.6" "1097.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5381305641147496779" "False" "High" "IsMasterProtein" "Q9HAV7" "GrpE protein homolog 1, mitochondrial OS=Homo sapiens OX=9606 GN=GRPEL1 PE=1 SV=2" "0.000" "False" "28.305" "38" "8" "18" "8" "217" "24.3" "8.12" "58.71" "8" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf01025" "80273" "ENSG00000109519" "GRPEL1" "B2R783; hsa:80273; Q549M6; Q9HAV7" "" "Mitochondrial protein import" "1" "0" "0.979" "0.957" "0.944" "0.951" "1.037" "0.952" "0.993" "0.952" "0.970" "2836.9" "2776.1" "2713.6" "2676.6" "2697.0" "2940.8" "2700.4" "2818.0" "2699.3" "2751.3" "" "" "" "" "" "" "" "" "" "" "2658.1" "2297.2" "2519.3" "2069.1" "2298.9" "2809.7" "2467.5" "2502.1" "2699.3" "2649.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3688625229951110619" "False" "High" "IsMasterProtein" "Cont_P02538" "Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3" "0.000" "True" "28.256" "12" "11" "16" "1" "564" "60.0" "8.00" "42.81" "11" "cell organization and biogenesis;stress response;other biological processes" "cytosol;cytoskeleton" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3853" "ENSG00000205420" "KRT6A" "A0A0S2Z428; A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4" "Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes" "Formation of the cornified envelope" "5" "1" "2.631" "0.587" "0.490" "0.671" "0.440" "1.678" "0.536" "0.320" "0.719" "73.0" "192.2" "42.9" "35.8" "49.0" "32.1" "122.5" "39.1" "23.3" "52.5" "" "" "" "" "" "" "" "" "" "" "68.4" "159.0" "39.8" "27.6" "41.8" "30.7" "112.0" "34.8" "23.3" "50.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1086525266732812690" "False" "High" "IsMasterProtein" "Q9Y5P4" "Ceramide transfer protein OS=Homo sapiens OX=9606 GN=CERT1 PE=1 SV=1" "0.000" "False" "28.251" "15" "10" "11" "10" "624" "70.8" "5.48" "31.73" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus" "transporter activity;kinase activity;other molecular function" "Pf00169, Pf01852" "10087" "ENSG00000113163" "CERT1" "A8K7S2; B3KUB7; hsa:10087; Q53YV1; Q53YV2; Q96Q85; Q96Q88; Q9H2S7; Q9H2S8; Q9Y5P4" "Sphingolipid pathway" "" "1" "0" "1.042" "1.058" "0.938" "0.964" "1.022" "0.883" "0.903" "0.986" "0.982" "967.8" "1008.5" "1023.7" "907.4" "932.9" "989.6" "854.2" "873.8" "954.7" "950.6" "" "" "" "" "" "" "" "" "" "" "906.8" "834.5" "950.3" "701.5" "795.2" "945.4" "780.5" "775.8" "954.7" "915.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-646999670011784093" "False" "High" "IsMasterProtein" "Q96S55" "ATPase WRNIP1 OS=Homo sapiens OX=9606 GN=WRNIP1 PE=1 SV=2" "0.000" "False" "28.216" "14" "8" "10" "8" "665" "72.1" "6.10" "34.79" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00004, Pf12002, Pf16193, Pf18279" "56897" "ENSG00000124535" "WRNIP1" "B2RDB0; hsa:56897; Q53EP6; Q59ET8; Q5W0E2; Q5W0E4; Q8WV26; Q96S55; Q9H681; Q9NRJ6" "" "" "0" "0" "1.024" "1.073" "0.963" "1.092" "1.057" "0.962" "0.916" "1.060" "1.051" "320.0" "327.7" "343.4" "308.1" "349.3" "338.3" "308.0" "293.2" "339.1" "336.2" "" "" "" "" "" "" "" "" "" "" "299.8" "271.2" "318.8" "238.2" "297.7" "323.2" "281.4" "260.3" "339.1" "323.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8952953409399985954" "False" "High" "IsMasterProtein" "Q9H1E3" "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 OS=Homo sapiens OX=9606 GN=NUCKS1 PE=1 SV=1" "0.000" "False" "28.196" "42" "8" "13" "8" "243" "27.3" "5.08" "47.05" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "64710" "ENSG00000069275" "NUCKS1" "hsa:64710; Q54AC0; Q5PXE7; Q9H1D6; Q9H1E3; Q9H723" "" "" "0" "0" "0.935" "0.868" "0.776" "0.776" "0.769" "0.858" "0.778" "0.813" "0.830" "2234.9" "2090.3" "1938.9" "1734.8" "1734.8" "1719.4" "1917.6" "1739.0" "1816.0" "1855.1" "" "" "" "" "" "" "" "" "" "" "2094.1" "1729.7" "1800.0" "1341.1" "1478.7" "1642.7" "1752.2" "1544.0" "1816.0" "1786.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6664537344047956195" "False" "High" "IsMasterProtein" "Q08209" "Protein phosphatase 3 catalytic subunit alpha OS=Homo sapiens OX=9606 GN=PPP3CA PE=1 SV=1" "0.000" "False" "28.189" "21" "10" "17" "5" "521" "58.7" "5.86" "51.09" "10" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149" "5530" "ENSG00000138814" "PPP3CA" "A1A441; A8K3B7; A8W6Z7; A8W6Z8; B5BUA2; hsa:5530; Q08209; Q8TAW9" "Physiological and pathological hypertrophy of the heart; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; G protein signaling pathways; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Serotonin and anxiety-related events; Serotonin and anxiety; Wnt signaling; Vitamin D in inflammatory diseases; Fragile X syndrome; Alzheimer's disease; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "FCERI mediated Ca+2 mobilization; CLEC7A (Dectin-1) induces NFAT activation; Ca2+ pathway; Calcineurin activates NFAT; DARPP-32 events" "26" "0" "1.010" "1.004" "1.007" "1.035" "0.998" "0.968" "1.026" "0.936" "1.024" "1084.8" "1096.1" "1089.6" "1091.9" "1122.9" "1082.9" "1050.0" "1112.6" "1015.1" "1110.5" "" "" "" "" "" "" "" "" "" "" "1016.4" "907.0" "1011.6" "844.1" "957.1" "1034.6" "959.4" "987.9" "1015.1" "1069.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3797665255168145849" "False" "High" "IsMasterProtein" "P46087" "28S rRNA (cytosine(4447)-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NOP2 PE=1 SV=2" "0.000" "False" "28.183" "12" "10" "12" "10" "812" "89.2" "9.23" "34.42" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01189, Pf08062, Pf17125" "4839" "ENSG00000111641" "NOP2" "A1A4Z3; B3KPD6; hsa:4839; P46087; Q05BA7; Q0P5S5; Q3KQS4; Q58F30" "Imatinib and chronic myeloid leukemia" "rRNA modification in the nucleus and cytosol; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation" "3" "0" "0.964" "0.973" "1.289" "1.281" "1.158" "2.043" "2.161" "1.979" "1.437" "584.2" "563.4" "568.6" "752.8" "748.6" "676.6" "1193.8" "1262.3" "1156.4" "839.3" "" "" "" "" "" "" "" "" "" "" "547.4" "466.2" "527.8" "581.9" "638.1" "646.5" "1090.8" "1120.8" "1156.4" "808.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4388967430464997560" "False" "High" "IsMasterProtein" "P43034" "Platelet-activating factor acetylhydrolase IB subunit beta OS=Homo sapiens OX=9606 GN=PAFAH1B1 PE=1 SV=2" "0.000" "False" "28.165" "25" "9" "15" "8" "410" "46.6" "7.37" "50.24" "9" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08513" "5048" "ENSG00000007168" "PAFAH1B1" "B2R7Q7; hsa:5048; P43034; Q8WZ88; Q8WZ89" "Wnt signaling pathway and pluripotency; Ciliary landscape; Neurogenesis regulation in the olfactory epithelium; PAFAH1B1 copy number variation" "AURKA Activation by TPX2; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "18" "0" "0.968" "0.987" "0.992" "0.992" "0.953" "0.974" "0.949" "0.939" "0.976" "1781.4" "1724.3" "1758.2" "1767.6" "1767.4" "1697.4" "1734.8" "1690.7" "1671.9" "1739.3" "" "" "" "" "" "" "" "" "" "" "1669.1" "1426.8" "1632.2" "1366.4" "1506.5" "1621.7" "1585.1" "1501.2" "1671.9" "1674.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5028999113090776511" "False" "High" "IsMasterProtein" "Q8WVB6" "Chromosome transmission fidelity protein 18 homolog OS=Homo sapiens OX=9606 GN=CHTF18 PE=1 SV=1" "0.000" "False" "28.156" "12" "9" "10" "8" "975" "107.3" "7.21" "33.75" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00004" "63922" "ENSG00000127586" "CHTF18" "B7ZBA2; D3DU68; hsa:63922; Q7Z6Y4; Q7Z6Y6; Q8WVB6; Q9BR83; Q9BRG5; Q9H7K3" "Gastric cancer network 2; 7q11.23 copy number variation syndrome" "Polymerase switching on the C-strand of the telomere" "3" "0" "0.996" "0.999" "1.008" "1.019" "0.994" "0.957" "0.962" "0.940" "0.989" "1898.4" "1891.4" "1895.8" "1913.2" "1935.0" "1887.5" "1817.0" "1826.7" "1784.6" "1876.6" "" "" "" "" "" "" "" "" "" "" "1778.8" "1565.1" "1760.0" "1479.0" "1649.3" "1803.3" "1660.3" "1621.9" "1784.6" "1806.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6229699224070924638" "False" "High" "IsMasterProtein" "Q13107" "Ubiquitin carboxyl-terminal hydrolase 4 OS=Homo sapiens OX=9606 GN=USP4 PE=1 SV=3" "0.000" "False" "28.146" "11" "11" "12" "9" "963" "108.5" "5.71" "28.36" "11" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00443, Pf06337, Pf14836" "7375" "ENSG00000114316" "USP4" "A8K6Y0; C9IY91; hsa:7375; O43452; O43453; Q08AK8; Q13107" "" "Ub-specific processing proteases; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "4" "0" "1.062" "0.918" "1.223" "0.990" "0.894" "1.233" "0.922" "0.824" "0.974" "505.4" "536.9" "464.1" "618.0" "500.6" "452.0" "623.1" "466.2" "416.3" "492.3" "" "" "" "" "" "" "" "" "" "" "473.6" "444.3" "430.8" "477.7" "426.7" "431.9" "569.4" "413.9" "416.3" "474.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7026483087037268354" "False" "High" "IsMasterProtein" "Q05823" "2-5A-dependent ribonuclease OS=Homo sapiens OX=9606 GN=RNASEL PE=1 SV=2" "0.000" "False" "28.140" "12" "10" "11" "10" "741" "83.5" "6.65" "29.16" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00023, Pf00069, Pf06479" "6041" "ENSG00000135828" "RNASEL" "hsa:6041; Q05823; Q5W0L2; Q6AI46" "" "OAS antiviral response; Interferon alpha/beta signaling" "2" "0" "0.966" "1.008" "0.997" "1.033" "1.031" "0.987" "0.951" "0.985" "1.043" "1051.4" "1015.1" "1059.3" "1047.8" "1086.3" "1083.8" "1037.2" "999.8" "1036.1" "1096.5" "" "" "" "" "" "" "" "" "" "" "985.1" "840.0" "983.4" "810.0" "926.0" "1035.5" "947.7" "887.7" "1036.1" "1055.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3146791204946970239" "False" "High" "IsMasterProtein" "Q9Y6W5" "Actin-binding protein WASF2 OS=Homo sapiens OX=9606 GN=WASF2 PE=1 SV=3" "0.000" "False" "28.128" "15" "8" "11" "8" "498" "54.3" "5.53" "38.86" "8" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "10163" "ENSG00000158195" "WASF2" "B4DZN0; hsa:10163; O60794; Q9UDY7; Q9Y6W5" "Regulation of actin cytoskeleton" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "8" "0" "1.018" "0.951" "0.965" "0.981" "1.000" "0.997" "0.923" "0.944" "0.961" "1044.3" "1062.8" "993.3" "1008.0" "1024.9" "1044.7" "1041.4" "963.5" "985.5" "1003.9" "" "" "" "" "" "" "" "" "" "" "978.5" "879.5" "922.1" "779.2" "873.6" "998.1" "951.6" "855.5" "985.5" "966.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4914593963434688361" "False" "High" "IsMasterProtein" "Q6P3X3" "Tetratricopeptide repeat protein 27 OS=Homo sapiens OX=9606 GN=TTC27 PE=1 SV=1" "0.000" "False" "28.119" "13" "11" "13" "11" "843" "96.6" "5.59" "37.20" "11" "" "" "" "Pf07719" "55622" "ENSG00000018699" "TTC27" "A6NKJ0; hsa:55622; Q6P3X3; Q96SS5; Q9BVF1; Q9NWR4; Q9NXG4" "" "" "0" "0" "0.970" "1.017" "1.024" "0.970" "1.008" "0.948" "0.981" "0.997" "1.041" "980.9" "951.9" "997.6" "1004.3" "951.6" "988.6" "930.2" "962.3" "978.3" "1021.2" "" "" "" "" "" "" "" "" "" "" "919.1" "787.7" "926.1" "776.4" "811.2" "944.5" "849.9" "854.5" "978.3" "983.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-700006474042265009" "False" "High" "IsMasterProtein" "Q7Z739" "YTH domain-containing family protein 3 OS=Homo sapiens OX=9606 GN=YTHDF3 PE=1 SV=1" "0.000" "False" "28.097" "15" "9" "12" "4" "585" "63.8" "9.04" "40.38" "9" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04146" "253943" "ENSG00000185728" "YTHDF3" "B3KXL4; hsa:253943; Q63Z37; Q659A3; Q7Z739" "" "" "0" "1" "1.009" "1.061" "1.054" "1.065" "1.076" "1.033" "1.071" "1.032" "1.059" "1017.1" "1026.0" "1079.3" "1071.7" "1083.6" "1094.8" "1051.0" "1089.9" "1049.8" "1077.5" "" "" "" "" "" "" "" "" "" "" "953.1" "849.0" "1002.0" "828.5" "923.7" "1046.0" "960.4" "967.7" "1049.8" "1037.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "854871700707894946" "False" "High" "IsMasterProtein" "Q9NZL4" "Hsp70-binding protein 1 OS=Homo sapiens OX=9606 GN=HSPBP1 PE=1 SV=2" "0.000" "False" "28.040" "26" "8" "16" "8" "359" "39.3" "5.21" "46.82" "8" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf08609" "23640" "ENSG00000133265" "HSPBP1" "B3KQP0; B4DG11; hsa:23640; O95351; Q6ZNU5; Q9NZL4" "" "" "0" "0" "1.041" "0.971" "1.127" "0.965" "0.985" "1.037" "0.971" "1.008" "1.027" "822.2" "856.1" "798.3" "926.4" "793.7" "810.0" "852.8" "798.1" "828.7" "844.7" "" "" "" "" "" "" "" "" "" "" "770.4" "708.4" "741.1" "716.1" "676.6" "773.9" "779.2" "708.6" "828.7" "813.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9116145290149312693" "False" "High" "IsMasterProtein" "P42226" "Signal transducer and activator of transcription 6 OS=Homo sapiens OX=9606 GN=STAT6 PE=1 SV=1" "0.000" "False" "28.035" "12" "10" "12" "10" "847" "94.1" "6.23" "34.29" "10" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf14596, Pf21354" "6778" "ENSG00000166888" "STAT6" "A8K316; B7ZA27; F5GXI9; hsa:6778; P42226; Q5FBW5; Q71UP4" "Thymic stromal lymphopoietin (TSLP) signaling pathway; Adipogenesis; VEGFA-VEGFR2 signaling; IL-4 signaling pathway; PDGFR-beta pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Neuroinflammation and glutamatergic signaling; Th17 cell differentiation pathway; Inflammatory bowel disease signaling; IL-19 signaling pathway" "Downstream signal transduction; Interleukin-4 and Interleukin-13 signaling; STAT6-mediated induction of chemokines" "13" "0" "1.000" "1.038" "0.996" "1.012" "1.006" "0.954" "0.949" "0.986" "1.022" "960.2" "960.2" "996.4" "956.7" "972.1" "966.3" "915.8" "911.1" "947.1" "981.1" "" "" "" "" "" "" "" "" "" "" "899.7" "794.6" "925.1" "739.6" "828.6" "923.2" "836.8" "809.0" "947.1" "944.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5299330729239778052" "False" "High" "IsMasterProtein" "Q6PFW1" "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS=Homo sapiens OX=9606 GN=PPIP5K1 PE=1 SV=1" "0.000" "False" "28.003" "6" "9" "10" "3" "1433" "159.4" "5.40" "32.60" "9" "other metabolic processes" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf00328, Pf18086" "9677" "ENSG00000168781" "PPIP5K1" "hsa:9677; O15082; Q5HYF8; Q6PFW1; Q7Z3A7; Q86TE7; Q86UV3; Q86UV4; Q86XW8; Q8IZN0" "" "Synthesis of pyrophosphates in the cytosol" "1" "0" "1.047" "1.044" "1.018" "0.972" "1.024" "1.030" "0.914" "0.908" "1.124" "53.6" "56.2" "56.0" "54.6" "52.1" "54.9" "55.2" "49.0" "48.7" "60.3" "" "" "" "" "" "" "" "" "" "" "50.3" "46.5" "52.0" "42.2" "44.4" "52.5" "50.5" "43.5" "48.7" "58.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "699961986535192658" "False" "High" "IsMasterProtein" "P84095" "Rho-related GTP-binding protein RhoG OS=Homo sapiens OX=9606 GN=RHOG PE=1 SV=1" "0.000" "False" "27.985" "49" "7" "8" "6" "191" "21.3" "8.12" "31.31" "7" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00071" "391" "ENSG00000177105" "RHOG" "hsa:391; P35238; P84095; Q8NI04" "Brain-derived neurotrophic factor (BDNF) signaling pathway" "Neutrophil degranulation; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RHOG GTPase cycle; RHO GTPases activate KTN1" "8" "1" "0.933" "0.919" "0.945" "0.882" "0.906" "0.833" "0.874" "0.847" "0.868" "1436.4" "1339.9" "1319.9" "1357.1" "1266.4" "1301.8" "1196.1" "1255.0" "1217.3" "1246.3" "" "" "" "" "" "" "" "" "" "" "1345.9" "1108.8" "1225.3" "1049.1" "1079.4" "1243.8" "1092.9" "1114.3" "1217.3" "1200.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4939366548436887845" "False" "High" "IsMasterProtein" "Q7L0Y3" "tRNA methyltransferase 10 homolog C OS=Homo sapiens OX=9606 GN=TRMT10C PE=1 SV=2" "0.000" "False" "27.969" "21" "9" "13" "9" "403" "47.3" "9.36" "39.12" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01746" "54931" "ENSG00000174173" "TRMT10C" "hsa:54931; Q7L0Y3; Q9NRG5; Q9NX54; Q9Y596" "" "tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion" "3" "0" "1.003" "1.039" "1.006" "1.075" "1.097" "0.997" "1.061" "0.996" "1.067" "2075.4" "2082.7" "2156.8" "2088.0" "2231.2" "2277.1" "2068.6" "2201.2" "2067.8" "2214.4" "" "" "" "" "" "" "" "" "" "" "1944.7" "1723.4" "2002.3" "1614.1" "1901.9" "2175.5" "1890.1" "1954.4" "2067.8" "2132.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2682819818401791106" "False" "High" "IsMasterProtein" "Q9NZJ0" "Denticleless protein homolog OS=Homo sapiens OX=9606 GN=DTL PE=1 SV=3" "0.000" "False" "27.966" "12" "10" "11" "10" "730" "79.4" "8.87" "33.82" "10" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400" "51514" "ENSG00000143476" "DTL" "A8K8H8; D3DT98; hsa:51514; Q5VT77; Q96SN0; Q9NW03; Q9NW34; Q9NWM5; Q9NZJ0" "" "Neddylation; Recognition of DNA damage by PCNA-containing replication complex" "2" "0" "0.988" "0.979" "1.006" "1.023" "0.976" "0.995" "0.995" "0.974" "1.009" "2174.4" "2149.4" "2128.6" "2186.8" "2225.1" "2122.0" "2163.1" "2163.0" "2118.5" "2195.0" "" "" "" "" "" "" "" "" "" "" "2037.4" "1778.6" "1976.1" "1690.5" "1896.6" "2027.3" "1976.5" "1920.5" "2118.5" "2113.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5513100547130879649" "False" "High" "IsMasterProtein" "P13797" "Plastin-3 OS=Homo sapiens OX=9606 GN=PLS3 PE=1 SV=4" "0.000" "False" "27.963" "10" "7" "13" "1" "630" "70.8" "5.60" "45.25" "7" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf13499" "5358" "ENSG00000102024" "PLS3" "A8K579; B1AQ09; B4DGB4; B7Z6M1; hsa:5358; P13797; Q86YI6" "" "" "0" "0" "0.788" "0.919" "0.922" "0.897" "0.894" "0.915" "0.895" "0.795" "0.886" "518.4" "408.5" "476.4" "478.0" "465.1" "463.3" "474.5" "463.8" "412.2" "459.1" "" "" "" "" "" "" "" "" "" "" "485.7" "338.0" "442.3" "369.5" "396.4" "442.6" "433.6" "411.8" "412.2" "442.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7711402174933544761" "False" "High" "IsMasterProtein" "Q8NG31" "Kinetochore scaffold 1 OS=Homo sapiens OX=9606 GN=KNL1 PE=1 SV=3" "0.000" "False" "27.928" "4" "11" "11" "11" "2342" "265.2" "5.47" "28.00" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "Pf18210, Pf19221" "57082" "ENSG00000137812" "KNL1" "hsa:57082; Q8NG31; Q8NHE1; Q8WXA6; Q9HCK2; Q9NR92" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere" "7" "0" "0.950" "0.924" "0.994" "0.963" "0.961" "0.969" "0.915" "0.915" "1.008" "1208.9" "1148.5" "1116.4" "1201.3" "1163.7" "1161.4" "1171.2" "1105.8" "1106.2" "1218.0" "" "" "" "" "" "" "" "" "" "" "1132.7" "950.4" "1036.5" "928.7" "991.9" "1109.6" "1070.2" "981.8" "1106.2" "1172.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6816817128509432528" "False" "High" "IsMasterProtein" "P10155" "RNA-binding protein RO60 OS=Homo sapiens OX=9606 GN=RO60 PE=1 SV=2" "0.000" "False" "27.923" "18" "10" "14" "10" "538" "60.6" "8.03" "48.92" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05731" "6738" "ENSG00000116747" "RO60" "B2RBB9; hsa:6738; P10155; Q5LJ98; Q5LJ99; Q5LJA0; Q86WL3; Q86WL4; Q92787; Q9H1W6" "" "" "0" "0" "0.950" "0.975" "0.902" "0.898" "0.942" "0.878" "0.953" "0.944" "0.921" "1388.4" "1319.4" "1353.6" "1251.7" "1246.1" "1308.1" "1219.5" "1322.5" "1310.6" "1278.5" "" "" "" "" "" "" "" "" "" "" "1300.9" "1091.8" "1256.6" "967.6" "1062.1" "1249.8" "1114.3" "1174.2" "1310.6" "1231.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7748730165992048021" "False" "High" "IsMasterProtein" "Q6UWE0" "E3 ubiquitin-protein ligase LRSAM1 OS=Homo sapiens OX=9606 GN=LRSAM1 PE=1 SV=1" "0.000" "False" "27.907" "12" "9" "12" "9" "723" "83.5" "5.94" "32.64" "9" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf07647, Pf13855, Pf13920" "90678" "ENSG00000148356" "LRSAM1" "Q5VVV0; Q6UWE0; Q8NB40; Q96GT5; Q96MX5; Q96MZ7" "Intracellular trafficking proteins involved in CMT neuropathy" "Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.042" "1.053" "1.106" "1.075" "1.044" "1.010" "0.972" "1.024" "1.026" "387.3" "403.7" "407.7" "428.5" "416.3" "404.5" "391.3" "376.5" "396.6" "397.3" "" "" "" "" "" "" "" "" "" "" "362.9" "334.0" "378.5" "331.2" "354.8" "386.5" "357.5" "334.3" "396.6" "382.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9099415838211122916" "False" "High" "IsMasterProtein" "P33981" "Dual specificity protein kinase TTK OS=Homo sapiens OX=9606 GN=TTK PE=1 SV=2" "0.000" "False" "27.881" "12" "9" "10" "9" "857" "97.0" "8.16" "29.21" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "7272" "ENSG00000112742" "TTK" "A8K8U5; B2RDW2; E1P543; hsa:7272; P33981; Q15272; Q5TCS0; Q9BW51; Q9NTM0" "Cell cycle; Retinoblastoma gene in cancer" "" "2" "0" "0.972" "0.918" "0.942" "0.968" "0.942" "0.898" "0.883" "0.885" "0.894" "1903.7" "1851.3" "1748.1" "1794.1" "1841.9" "1793.8" "1709.7" "1681.6" "1684.0" "1701.6" "" "" "" "" "" "" "" "" "" "" "1783.7" "1531.9" "1622.9" "1387.0" "1569.9" "1713.8" "1562.2" "1493.1" "1684.0" "1638.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5272844491039920934" "False" "High" "IsMasterProtein" "P09661" "U2 small nuclear ribonucleoprotein A' OS=Homo sapiens OX=9606 GN=SNRPA1 PE=1 SV=2" "0.000" "False" "27.859" "27" "8" "18" "8" "255" "28.4" "8.62" "61.84" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf14580" "6627" "ENSG00000131876" "SNRPA1" "B2R5I6; hsa:6627; P09661; Q8TBD2" "mRNA processing" "mRNA Splicing - Major Pathway; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "3" "0" "1.140" "1.053" "1.159" "1.145" "1.109" "1.107" "1.149" "1.127" "1.088" "1244.8" "1418.7" "1311.2" "1442.7" "1425.8" "1380.8" "1378.5" "1430.3" "1402.6" "1354.4" "" "" "" "" "" "" "" "" "" "" "1166.4" "1174.0" "1217.3" "1115.3" "1215.3" "1319.2" "1259.6" "1270.0" "1402.6" "1304.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8474719942598486325" "False" "High" "IsMasterProtein" "Q8WYA6" "Beta-catenin-like protein 1 OS=Homo sapiens OX=9606 GN=CTNNBL1 PE=1 SV=1" "0.000" "False" "27.858" "18" "10" "12" "10" "563" "65.1" "5.05" "31.01" "10" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08216" "56259" "ENSG00000132792" "CTNNBL1" "B4DE16; hsa:56259; Q0VAL9; Q0VAM0; Q53HI8; Q5JWZ2; Q5JWZ3; Q5JWZ7; Q5JWZ8; Q8N454; Q8NCL2; Q8TBD6; Q8WYA6; Q96KD2; Q9H7A5; Q9NQF9; Q9NTX0; Q9Y3M7" "" "mRNA Splicing - Major Pathway" "1" "0" "1.018" "1.067" "1.070" "1.053" "1.059" "1.160" "1.183" "1.136" "1.104" "1420.7" "1445.7" "1516.0" "1520.6" "1496.0" "1504.1" "1647.5" "1680.7" "1614.4" "1568.1" "" "" "" "" "" "" "" "" "" "" "1331.2" "1196.3" "1407.4" "1175.5" "1275.2" "1437.0" "1505.3" "1492.3" "1614.4" "1509.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7105726009165371323" "False" "High" "IsMasterProtein" "P13995" "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD2 PE=1 SV=2" "0.000" "False" "27.822" "28" "9" "17" "9" "350" "37.9" "8.73" "66.56" "9" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00763, Pf02882" "10797" "ENSG00000065911" "MTHFD2" "hsa:10797; P13995; Q53G90; Q53GV5; Q53S36; Q7Z650" "Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways" "Metabolism of folate and pterines" "4" "0" "0.964" "0.977" "0.985" "0.964" "0.971" "0.924" "0.940" "0.919" "0.928" "2189.7" "2111.0" "2138.9" "2157.5" "2110.9" "2126.0" "2023.9" "2057.9" "2012.2" "2033.1" "" "" "" "" "" "" "" "" "" "" "2051.8" "1746.8" "1985.7" "1667.9" "1799.2" "2031.2" "1849.3" "1827.2" "2012.2" "1957.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1948602544583202968" "False" "High" "IsMasterProtein" "Q13042" "Cell division cycle protein 16 homolog OS=Homo sapiens OX=9606 GN=CDC16 PE=1 SV=2" "0.000" "False" "27.776" "15" "9" "12" "9" "620" "71.6" "5.85" "39.01" "9" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf12895, Pf13424" "8881" "ENSG00000130177" "CDC16" "A2A365; hsa:8881; Q13042; Q5T8C8; Q7Z651; Q96AE6; Q9Y564" "Cell cycle" "Antigen processing: Ubiquitination & Proteasome degradation; Senescence-Associated Secretory Phenotype (SASP); APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "1.009" "1.043" "1.023" "1.016" "0.999" "0.955" "0.942" "0.928" "1.024" "1184.2" "1195.0" "1235.4" "1211.0" "1203.1" "1182.5" "1131.3" "1115.2" "1099.2" "1213.1" "" "" "" "" "" "" "" "" "" "" "1109.6" "988.9" "1146.9" "936.2" "1025.5" "1129.8" "1033.7" "990.2" "1099.2" "1168.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3098195104215073585" "False" "High" "IsMasterProtein" "P23919" "Thymidylate kinase OS=Homo sapiens OX=9606 GN=DTYMK PE=1 SV=4" "0.000" "False" "27.750" "38" "9" "17" "9" "212" "23.8" "8.27" "60.27" "9" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf02223" "1841" "ENSG00000168393" "DTYMK" "B7ZW70; hsa:1841; P23919; Q6FGX1; Q9BUX4" "Pyrimidine metabolism; 2q37 copy number variation syndrome" "Interconversion of nucleotide di- and triphosphates" "3" "0" "0.980" "1.002" "0.935" "0.989" "1.009" "0.961" "0.990" "0.957" "0.966" "1118.9" "1096.5" "1121.1" "1046.7" "1107.1" "1129.4" "1075.5" "1108.0" "1070.3" "1080.8" "" "" "" "" "" "" "" "" "" "" "1048.4" "907.4" "1040.8" "809.2" "943.7" "1079.0" "982.7" "983.8" "1070.3" "1040.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2638301692080516805" "False" "High" "IsMasterProtein" "O95817" "BAG family molecular chaperone regulator 3 OS=Homo sapiens OX=9606 GN=BAG3 PE=1 SV=3" "0.000" "False" "27.748" "18" "10" "11" "10" "575" "61.6" "6.95" "31.66" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00397, Pf02179" "9531" "ENSG00000151929" "BAG3" "A8K5L8; hsa:9531; O95817; Q3B763; Q9NT20; Q9P120" "Cell interactions of the pancreatic cancer microenvironment" "Regulation of HSF1-mediated heat shock response" "2" "0" "1.043" "0.990" "1.054" "1.010" "1.001" "1.071" "1.023" "0.984" "0.979" "1036.6" "1080.7" "1026.7" "1092.6" "1046.5" "1037.6" "1109.9" "1060.2" "1020.3" "1014.8" "" "" "" "" "" "" "" "" "" "" "971.3" "894.3" "953.1" "844.6" "892.0" "991.3" "1014.1" "941.4" "1020.3" "977.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4926655616225133563" "False" "High" "IsMasterProtein" "Q86TI0" "TBC1 domain family member 1 OS=Homo sapiens OX=9606 GN=TBC1D1 PE=1 SV=2" "0.000" "False" "27.731" "9" "11" "12" "11" "1168" "133.0" "6.96" "37.58" "11" "" "nucleus" "enzyme regulator activity" "Pf00566, Pf00640, Pf11830" "23216" "ENSG00000065882" "TBC1D1" "B7Z3D9; E9PGH8; hsa:23216; Q86TI0; Q96K82; Q9UPP4" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "2" "0" "0.997" "0.991" "0.964" "1.033" "1.011" "0.993" "0.983" "0.997" "1.006" "1406.6" "1402.1" "1393.8" "1356.1" "1452.5" "1422.6" "1397.4" "1382.1" "1402.2" "1414.4" "" "" "" "" "" "" "" "" "" "" "1318.0" "1160.2" "1293.9" "1048.3" "1238.1" "1359.2" "1276.9" "1227.1" "1402.2" "1361.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4935758421494429625" "False" "High" "IsMasterProtein" "P54277" "PMS1 protein homolog 1 OS=Homo sapiens OX=9606 GN=PMS1 PE=1 SV=1" "0.000" "False" "27.700" "9" "8" "10" "8" "932" "105.8" "6.67" "27.66" "8" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505, Pf01119, Pf02518" "5378" "ENSG00000064933" "PMS1" "D3DPI1; hsa:5378; P54277; Q4VAL4; Q5FBZ3; Q5FBZ6; Q5FBZ8" "" "" "0" "0" "1.057" "1.125" "1.173" "1.089" "1.123" "1.050" "1.078" "1.098" "1.098" "271.9" "287.3" "305.7" "319.0" "296.0" "305.2" "285.4" "293.0" "298.5" "298.6" "" "" "" "" "" "" "" "" "" "" "254.7" "237.8" "283.8" "246.6" "252.3" "291.6" "260.7" "260.1" "298.5" "287.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1695167521897825927" "False" "High" "IsMasterProtein" "P53609" "Geranylgeranyl transferase type-1 subunit beta OS=Homo sapiens OX=9606 GN=PGGT1B PE=1 SV=2" "0.000" "False" "27.696" "25" "9" "11" "9" "377" "42.3" "6.83" "33.99" "9" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00432" "5229" "ENSG00000164219" "PGGT1B" "hsa:5229; P53609; Q5MJP9" "" "" "0" "0" "0.930" "0.940" "0.954" "0.932" "0.922" "0.970" "0.942" "0.938" "0.972" "665.6" "619.0" "625.9" "635.2" "620.7" "613.9" "645.6" "627.1" "624.1" "647.2" "" "" "" "" "" "" "" "" "" "" "623.7" "512.2" "581.0" "491.0" "529.0" "586.5" "589.9" "556.8" "624.1" "623.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3813014236257881133" "False" "High" "IsMasterProtein" "P21291" "Cysteine and glycine-rich protein 1 OS=Homo sapiens OX=9606 GN=CSRP1 PE=1 SV=3" "0.000" "False" "27.678" "51" "7" "9" "7" "193" "20.6" "8.57" "32.81" "7" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412" "1465" "ENSG00000159176" "CSRP1" "A8K268; hsa:1465; P21291; Q5U0J2" "MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling" "MTF1 activates gene expression" "3" "0" "1.054" "0.980" "1.056" "0.972" "0.940" "0.988" "0.985" "0.922" "0.951" "1169.0" "1232.1" "1145.3" "1234.5" "1135.7" "1098.3" "1154.5" "1151.0" "1077.3" "1111.5" "" "" "" "" "" "" "" "" "" "" "1095.4" "1019.5" "1063.3" "954.4" "968.1" "1049.3" "1054.9" "1022.0" "1077.3" "1070.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3823742586445689125" "False" "High" "IsMasterProtein" "Q9NPQ8" "Synembryn-A OS=Homo sapiens OX=9606 GN=RIC8A PE=1 SV=3" "0.000" "False" "27.657" "19" "9" "15" "9" "531" "59.7" "5.33" "38.65" "9" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf10165" "60626" "ENSG00000177963" "RIC8A" "hsa:60626; Q0P508; Q2T9J1; Q7Z352; Q96EZ1; Q96SZ2; Q9H064; Q9H5H3; Q9H9E7; Q9NPQ8" "" "" "0" "0" "1.030" "1.063" "1.030" "0.999" "0.977" "0.999" "0.974" "0.930" "0.961" "246.3" "253.7" "261.9" "253.6" "245.9" "240.6" "246.1" "239.9" "229.1" "236.8" "" "" "" "" "" "" "" "" "" "" "230.7" "209.9" "243.1" "196.1" "209.6" "229.9" "224.8" "213.0" "229.1" "228.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8194889804076803831" "False" "High" "IsMasterProtein" "Q9UBU9" "Nuclear RNA export factor 1 OS=Homo sapiens OX=9606 GN=NXF1 PE=1 SV=1" "0.000" "False" "27.636" "16" "9" "11" "9" "619" "70.1" "8.51" "34.34" "9" "other metabolic processes;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02136, Pf03943, Pf09162" "10482" "ENSG00000162231" "NXF1" "B4E269; hsa:10482; Q99799; Q9UBU9; Q9UQL2" "mRNA processing" "Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript" "5" "0" "1.028" "1.028" "0.999" "1.040" "1.076" "1.119" "1.135" "1.138" "1.080" "677.8" "696.6" "696.9" "677.3" "704.8" "729.2" "758.3" "769.5" "771.0" "731.7" "" "" "" "" "" "" "" "" "" "" "635.1" "576.4" "647.0" "523.6" "600.8" "696.7" "692.9" "683.3" "771.0" "704.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8725302829576246174" "False" "High" "IsMasterProtein" "P63151" "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R2A PE=1 SV=1" "0.000" "False" "27.612" "17" "8" "11" "6" "447" "51.7" "6.20" "37.82" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "" "5520" "ENSG00000221914" "PPP2R2A" "B2RBU8; B4E1T7; hsa:5520; P50409; P63151; Q00007" "Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; Initiation of Nuclear Envelope (NE) Reformation" "7" "2" "1.002" "0.984" "1.038" "0.965" "0.977" "0.946" "0.929" "0.947" "0.961" "774.2" "775.8" "761.7" "803.3" "746.7" "756.0" "732.3" "719.1" "732.8" "744.0" "" "" "" "" "" "" "" "" "" "" "725.4" "642.0" "707.1" "621.0" "636.5" "722.3" "669.2" "638.5" "732.8" "716.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3538184499835993456" "False" "High" "IsMasterProtein" "P43897" "Elongation factor Ts, mitochondrial OS=Homo sapiens OX=9606 GN=TSFM PE=1 SV=2" "0.000" "False" "27.609" "32" "8" "9" "8" "325" "35.4" "8.38" "33.30" "8" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity" "Pf00889" "10102" "ENSG00000123297" "TSFM" "B4E391; F5H2T7; hsa:10102; P43897; Q561V7; Q8TBC2; Q9UQK0" "" "Mitochondrial translation elongation" "1" "0" "0.965" "0.992" "0.953" "0.974" "0.986" "0.948" "0.950" "0.959" "0.976" "968.9" "935.2" "961.1" "923.1" "943.6" "955.1" "918.9" "920.5" "928.7" "945.9" "" "" "" "" "" "" "" "" "" "" "907.9" "773.8" "892.3" "713.6" "804.3" "912.5" "839.6" "817.3" "928.7" "910.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8752239950939414056" "False" "High" "IsMasterProtein" "P18754" "Regulator of chromosome condensation OS=Homo sapiens OX=9606 GN=RCC1 PE=1 SV=1" "0.000" "False" "27.600" "24" "8" "14" "8" "421" "44.9" "7.52" "51.87" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00415" "1104" "ENSG00000180198" "RCC1" "hsa:1104; P18754; Q16269; Q6NT97" "22q11.2 copy number variation syndrome" "Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation" "4" "0" "0.935" "0.968" "0.959" "0.928" "0.923" "0.939" "0.956" "0.958" "0.950" "1690.1" "1580.1" "1635.7" "1621.0" "1568.9" "1560.4" "1586.6" "1616.6" "1619.5" "1606.3" "" "" "" "" "" "" "" "" "" "" "1583.7" "1307.5" "1518.5" "1253.1" "1337.3" "1490.8" "1449.7" "1435.4" "1619.5" "1546.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-508494988063673287" "False" "High" "IsMasterProtein" "Q9NXG2" "THUMP domain-containing protein 1 OS=Homo sapiens OX=9606 GN=THUMPD1 PE=1 SV=2" "0.000" "False" "27.587" "27" "9" "16" "9" "353" "39.3" "7.88" "54.48" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02926" "55623" "ENSG00000066654" "THUMPD1" "hsa:55623; Q9BWC3; Q9NXG2" "" "rRNA modification in the nucleus and cytosol" "1" "0" "0.988" "0.983" "0.923" "0.949" "0.978" "0.964" "0.977" "0.985" "0.954" "2179.8" "2153.3" "2141.8" "2011.6" "2069.5" "2132.3" "2101.7" "2128.9" "2146.4" "2080.6" "" "" "" "" "" "" "" "" "" "" "2042.4" "1781.8" "1988.4" "1555.1" "1764.0" "2037.2" "1920.4" "1890.3" "2146.4" "2003.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5230612763215460817" "False" "High" "IsMasterProtein" "Q99829" "Copine-1 OS=Homo sapiens OX=9606 GN=CPNE1 PE=1 SV=1" "0.000" "False" "27.573" "15" "8" "17" "8" "537" "59.0" "5.83" "53.30" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf07002" "8904" "ENSG00000214078" "CPNE1" "E1P5Q4; hsa:8904; Q6IBL3; Q99829; Q9H243; Q9NTZ7" "" "Neutrophil degranulation; Glycerophospholipid biosynthesis" "2" "0" "0.972" "1.029" "0.994" "0.983" "0.999" "0.974" "1.021" "1.011" "0.992" "1901.1" "1848.7" "1956.1" "1888.7" "1869.0" "1899.8" "1850.9" "1940.4" "1921.2" "1884.9" "" "" "" "" "" "" "" "" "" "" "1781.3" "1529.8" "1816.0" "1460.1" "1593.1" "1815.1" "1691.2" "1722.8" "1921.2" "1814.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6898362588139573585" "False" "High" "IsMasterProtein" "Q01105" "Protein SET OS=Homo sapiens OX=9606 GN=SET PE=1 SV=3" "0.000" "False" "27.573" "30" "8" "24" "8" "290" "33.5" "4.32" "72.22" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00956" "6418" "ENSG00000119335" "SET" "A5A5H4; A6NGV1; B4DUE2; hsa:6418; Q01105; Q15541; Q5VXV1; Q5VXV2; Q6FHZ5" "Histone modifications; VEGFA-VEGFR2 signaling" "HuR (ELAVL1) binds and stabilizes mRNA; Condensation of Prophase Chromosomes" "4" "0" "1.129" "1.057" "1.137" "1.046" "0.922" "0.991" "1.048" "0.995" "1.007" "2282.4" "2578.0" "2411.8" "2595.8" "2386.6" "2104.3" "2262.0" "2392.0" "2271.8" "2298.6" "" "" "" "" "" "" "" "" "" "" "2138.6" "2133.2" "2239.0" "2006.7" "2034.2" "2010.5" "2066.9" "2123.9" "2271.8" "2213.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1822975009015350041" "False" "High" "IsMasterProtein" "P60228" "Eukaryotic translation initiation factor 3 subunit E OS=Homo sapiens OX=9606 GN=EIF3E PE=1 SV=1" "0.000" "False" "27.562" "24" "10" "11" "10" "445" "52.2" "6.04" "33.90" "10" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01399, Pf09440, Pf21357" "3646" "ENSG00000104408" "EIF3E" "hsa:3646; O43902; P60228; Q64058; Q64059; Q64252; Q6FG33; Q8WVK4" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "1.019" "0.955" "0.963" "0.903" "0.870" "1.163" "1.171" "1.108" "1.015" "1225.4" "1249.3" "1170.3" "1179.7" "1106.1" "1065.5" "1425.0" "1435.4" "1358.1" "1243.6" "" "" "" "" "" "" "" "" "" "" "1148.2" "1033.8" "1086.5" "912.0" "942.8" "1018.0" "1302.1" "1274.5" "1358.1" "1197.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "212659989141045460" "False" "High" "IsMasterProtein" "P78356" "Phosphatidylinositol 5-phosphate 4-kinase type-2 beta OS=Homo sapiens OX=9606 GN=PIP4K2B PE=1 SV=1" "0.000" "False" "27.556" "23" "9" "11" "5" "416" "47.3" "7.33" "30.11" "9" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "kinase activity;other molecular function" "Pf01504" "8396" "ENSG00000276293; ENSG00000277292" "PIP4K2B" "hsa:8396; P78356; Q5U0E8; Q8TBP2" "Regulation of actin cytoskeleton; 17q12 copy number variation syndrome" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "6" "1" "0.971" "0.965" "0.964" "1.003" "1.006" "0.926" "0.883" "0.931" "1.002" "512.7" "497.9" "495.0" "494.2" "514.4" "515.8" "474.9" "453.0" "477.3" "513.9" "" "" "" "" "" "" "" "" "" "" "480.4" "412.0" "459.6" "382.0" "438.5" "492.8" "434.0" "402.2" "477.3" "494.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5857120018545354279" "False" "High" "IsMasterProtein" "Q8NFH3" "Nucleoporin Nup43 OS=Homo sapiens OX=9606 GN=NUP43 PE=1 SV=1" "0.000" "False" "27.533" "27" "9" "12" "9" "380" "42.1" "5.63" "34.81" "9" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "348995" "ENSG00000120253" "NUP43" "B4E2F0; hsa:348995; Q8NFH3; Q9H8S0" "" "Separation of Sister Chromatids; Regulation of HSF1-mediated heat shock response; SUMOylation of chromatin organization proteins; SUMOylation of DNA damage response and repair proteins; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Late Events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "35" "0" "0.987" "0.970" "0.970" "1.013" "1.010" "0.954" "1.051" "0.962" "1.037" "687.1" "678.5" "666.8" "666.6" "695.8" "693.9" "655.9" "722.0" "661.1" "712.9" "" "" "" "" "" "" "" "" "" "" "643.9" "561.5" "619.1" "515.3" "593.1" "663.0" "599.3" "641.0" "661.1" "686.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3557205944014884156" "False" "High" "IsMasterProtein" "P20339" "Ras-related protein Rab-5A OS=Homo sapiens OX=9606 GN=RAB5A PE=1 SV=2" "0.000" "False" "27.505" "39" "7" "8" "4" "215" "23.6" "8.15" "28.98" "7" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5868" "ENSG00000144566" "RAB5A" "B4DJA5; hsa:5868; P20339; Q6FI44" "Amyotrophic lateral sclerosis (ALS); VEGFA-VEGFR2 signaling; Ebola virus infection in host; Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway; 16p11.2 distal deletion syndrome; Vasopressin-regulated water reabsorption" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Factors involved in megakaryocyte development and platelet production; Prevention of phagosomal-lysosomal fusion; TBC/RABGAPs" "16" "3" "1.013" "1.010" "1.057" "1.026" "0.957" "1.031" "0.988" "0.988" "1.004" "1046.2" "1060.2" "1056.4" "1105.5" "1073.7" "1000.7" "1078.2" "1034.1" "1033.4" "1050.0" "" "" "" "" "" "" "" "" "" "" "980.2" "877.3" "980.8" "854.6" "915.2" "956.1" "985.2" "918.2" "1033.4" "1011.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625236690753071245" "False" "High" "IsMasterProtein" "P22061" "Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens OX=9606 GN=PCMT1 PE=1 SV=4" "0.000" "False" "27.482" "34" "7" "12" "7" "227" "24.6" "7.21" "41.52" "7" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01135" "5110" "ENSG00000120265" "PCMT1" "A8K109; hsa:5110; J3KP72; P22061; Q14661; Q16556; Q5VYC1; Q5VYC2; Q93061; Q96II9; Q99625; Q9BQV7; Q9BQV8; Q9NP03" "Primary ovarian insufficiency" "Protein repair" "2" "0" "0.937" "0.958" "0.951" "1.005" "0.954" "0.942" "0.966" "0.955" "0.962" "1202.5" "1126.8" "1151.8" "1144.0" "1208.5" "1147.0" "1132.2" "1161.2" "1147.9" "1156.5" "" "" "" "" "" "" "" "" "" "" "1126.7" "932.4" "1069.3" "884.4" "1030.1" "1095.8" "1034.5" "1031.0" "1147.9" "1113.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-824304309308168891" "False" "High" "IsMasterProtein" "Q14005" "Pro-interleukin-16 OS=Homo sapiens OX=9606 GN=IL16 PE=1 SV=4" "0.000" "False" "27.473" "9" "9" "11" "9" "1332" "141.7" "8.06" "40.64" "9" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding" "Pf00595" "3603" "ENSG00000172349" "IL16" "A6NM20; A8MU65; B5TY35; B9EGR6; H3BVH5; hsa:3603; Q14005; Q16435; Q6VVE6; Q6ZMQ7; Q9UP18" "" "Other interleukin signaling" "1" "0" "0.959" "0.955" "0.985" "1.002" "1.006" "0.998" "0.957" "0.993" "0.985" "1143.5" "1096.6" "1091.6" "1126.9" "1145.7" "1150.5" "1140.7" "1094.0" "1135.2" "1126.8" "" "" "" "" "" "" "" "" "" "" "1071.5" "907.5" "1013.5" "871.2" "976.6" "1099.1" "1042.3" "971.4" "1135.2" "1085.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8378095313839820512" "False" "High" "IsMasterProtein" "P15923" "Transcription factor E2-alpha OS=Homo sapiens OX=9606 GN=TCF3 PE=1 SV=1" "0.000" "False" "27.467" "11" "7" "9" "6" "654" "67.6" "6.47" "37.16" "7" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "6929" "ENSG00000071564" "TCF3" "hsa:6929; P15883; P15923; Q14208; Q14635; Q14636; Q2TB39; Q2TB40; Q9UPI9" "Ectoderm differentiation; Ectoderm differentiation; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; lncRNA in canonical Wnt signaling and colorectal cancer; Neurogenesis regulation in the olfactory epithelium; Sudden infant death syndrome (SIDS) susceptibility pathways" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Myogenesis" "9" "0" "0.951" "0.954" "0.893" "0.967" "1.020" "0.913" "0.963" "0.934" "0.980" "1862.2" "1770.2" "1777.4" "1663.9" "1801.4" "1898.9" "1699.8" "1793.3" "1738.6" "1824.1" "" "" "" "" "" "" "" "" "" "" "1744.9" "1464.8" "1650.0" "1286.2" "1535.5" "1814.3" "1553.2" "1592.3" "1738.6" "1756.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5016840321552797541" "False" "High" "IsMasterProtein" "Q96KP1" "Exocyst complex component 2 OS=Homo sapiens OX=9606 GN=EXOC2 PE=1 SV=1" "0.000" "False" "27.465" "9" "10" "13" "10" "924" "104.0" "6.90" "37.98" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01833, Pf15469" "55770" "ENSG00000112685" "EXOC2" "B2RBE6; hsa:55770; Q5JPC8; Q96AN6; Q96KP1; Q9NUZ8; Q9UJM7" "RalA downstream regulated genes; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "7" "0" "0.972" "0.948" "0.940" "0.960" "1.007" "0.932" "0.917" "0.953" "0.992" "899.9" "874.4" "853.0" "845.6" "863.6" "906.6" "838.7" "825.2" "857.5" "892.9" "" "" "" "" "" "" "" "" "" "" "843.2" "723.5" "791.9" "653.7" "736.1" "866.2" "766.3" "732.7" "857.5" "859.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7662049170687489427" "False" "High" "IsMasterProtein" "Q9Y376" "Calcium-binding protein 39 OS=Homo sapiens OX=9606 GN=CAB39 PE=1 SV=1" "0.000" "False" "27.464" "26" "10" "12" "10" "341" "39.8" "6.89" "38.74" "10" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf08569" "51719" "ENSG00000135932" "CAB39" "A8K8L7; hsa:51719; Q9Y376" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias" "Neutrophil degranulation; Energy dependent regulation of mTOR by LKB1-AMPK" "6" "0" "0.956" "1.003" "0.945" "0.922" "0.980" "0.930" "0.977" "0.950" "0.958" "1897.5" "1814.7" "1903.6" "1792.7" "1750.3" "1860.0" "1764.7" "1853.8" "1802.7" "1817.7" "" "" "" "" "" "" "" "" "" "" "1778.0" "1501.7" "1767.3" "1385.9" "1491.9" "1777.0" "1612.4" "1646.0" "1802.7" "1750.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-101820050033511890" "False" "High" "IsMasterProtein" "Q14966" "Zinc finger protein 638 OS=Homo sapiens OX=9606 GN=ZNF638 PE=1 SV=2" "0.000" "False" "27.428" "5" "10" "11" "10" "1978" "220.5" "6.38" "31.83" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf12171" "27332" "ENSG00000075292" "ZNF638" "A0A096LPH6; B5MDV1; B7ZLD1; hsa:27332; Q14966; Q53R34; Q5XJ05; Q68DP3; Q6P2H2; Q7Z3T7; Q8NF92; Q8TCA1; Q9H2G1; Q9NP37" "" "Transcriptional regulation of white adipocyte differentiation" "1" "0" "1.066" "0.999" "1.086" "1.084" "1.105" "1.485" "1.428" "1.442" "1.236" "900.8" "960.1" "899.9" "978.3" "976.9" "995.8" "1338.0" "1286.7" "1298.6" "1113.0" "" "" "" "" "" "" "" "" "" "" "844.1" "794.5" "835.4" "756.3" "832.7" "951.4" "1222.6" "1142.5" "1298.6" "1071.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8376641896775859350" "False" "High" "IsMasterProtein" "O95104" "SR-related and CTD-associated factor 4 OS=Homo sapiens OX=9606 GN=SCAF4 PE=1 SV=3" "0.000" "False" "27.388" "8" "9" "11" "8" "1147" "125.8" "9.55" "36.10" "9" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf04818" "57466" "ENSG00000156304" "SCAF4" "C9JLZ0; hsa:57466; O95104; Q0P5W8; Q6P1M5; Q8N3I8; Q9UFM1; Q9ULP8" "" "" "0" "0" "0.903" "0.953" "0.952" "0.969" "0.972" "1.000" "0.997" "0.977" "0.938" "1354.4" "1222.7" "1290.8" "1289.6" "1312.2" "1316.3" "1354.2" "1350.2" "1323.5" "1270.0" "" "" "" "" "" "" "" "" "" "" "1269.1" "1011.8" "1198.4" "996.9" "1118.5" "1257.6" "1237.4" "1198.9" "1323.5" "1222.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8488452650529328010" "False" "High" "IsMasterProtein" "Q5VIR6" "Vacuolar protein sorting-associated protein 53 homolog OS=Homo sapiens OX=9606 GN=VPS53 PE=1 SV=2" "0.000" "False" "27.382" "11" "10" "13" "10" "832" "94.3" "6.70" "40.00" "10" "transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04100, Pf16854" "55275" "ENSG00000141252; ENSG00000283883" "VPS53" "A8K2S8; B3FH42; hsa:55275; Q5VIR6; Q8WYW3; Q9BRR2; Q9BY02; Q9NV25" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "1.010" "0.986" "1.051" "0.995" "0.993" "1.023" "0.955" "0.978" "1.014" "892.5" "901.6" "880.2" "938.3" "888.5" "886.5" "912.8" "852.5" "873.2" "904.9" "" "" "" "" "" "" "" "" "" "" "836.3" "746.0" "817.2" "725.4" "757.3" "846.9" "834.0" "757.0" "873.2" "871.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1684590373995147366" "False" "High" "IsMasterProtein" "P35237" "Serpin B6 OS=Homo sapiens OX=9606 GN=SERPINB6 PE=1 SV=3" "0.000" "False" "27.326" "24" "8" "11" "7" "376" "42.6" "5.27" "27.89" "8" "stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00079" "5269" "ENSG00000124570" "SERPINB6" "B2RBA8; hsa:5269; P35237; Q59F97; Q5TD06; Q7Z2Y7; Q96J44; Q9UDI7" "Ectoderm differentiation" "Neutrophil degranulation; Dissolution of Fibrin Clot" "3" "0" "0.948" "0.944" "0.994" "0.994" "1.044" "1.236" "1.246" "1.177" "1.135" "197.4" "187.2" "186.3" "196.3" "196.2" "206.0" "244.1" "246.0" "232.4" "224.0" "" "" "" "" "" "" "" "" "" "" "185.0" "154.9" "173.0" "151.7" "167.3" "196.8" "223.0" "218.4" "232.4" "215.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5794288011295636240" "False" "High" "IsMasterProtein" "O60502" "Protein O-GlcNAcase OS=Homo sapiens OX=9606 GN=OGA PE=1 SV=2" "0.000" "False" "27.321" "9" "10" "14" "10" "916" "102.8" "4.91" "42.58" "10" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf07555" "10724" "ENSG00000198408" "OGA" "B7WPB9; D3DR79; E9PGF9; hsa:10724; O60502; O75166; Q86WV0; Q8IV98; Q9BVA5; Q9HAR0" "" "" "0" "0" "1.010" "0.981" "0.933" "0.968" "0.980" "0.897" "0.923" "0.923" "0.944" "1664.8" "1681.1" "1633.3" "1553.3" "1611.3" "1631.2" "1493.6" "1535.9" "1536.8" "1571.4" "" "" "" "" "" "" "" "" "" "" "1559.9" "1391.1" "1516.3" "1200.8" "1373.4" "1558.5" "1364.8" "1363.8" "1536.8" "1513.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5309458315612800198" "False" "High" "IsMasterProtein" "O00178" "GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=GTPBP1 PE=1 SV=3" "0.000" "False" "27.315" "13" "9" "11" "9" "669" "72.4" "8.34" "30.50" "9" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144" "9567" "ENSG00000100226" "GTPBP1" "hsa:9567; O00178; Q6IC67" "" "" "0" "0" "1.046" "1.063" "1.075" "1.007" "1.004" "1.001" "0.962" "0.991" "1.043" "1400.5" "1464.8" "1489.3" "1505.3" "1410.9" "1406.2" "1401.6" "1347.8" "1388.1" "1460.3" "" "" "" "" "" "" "" "" "" "" "1312.3" "1212.1" "1382.7" "1163.7" "1202.6" "1343.4" "1280.7" "1196.7" "1388.1" "1406.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5588804604694799714" "False" "High" "IsMasterProtein" "P36957" "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLST PE=1 SV=4" "0.000" "False" "27.307" "16" "7" "12" "7" "453" "48.7" "8.95" "42.84" "7" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00198, Pf00364" "1743" "ENSG00000119689" "DLST" "B7Z5W8; E7ESY5; hsa:1743; P36957; Q7LDY7; Q9BQ32" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Metabolic reprogramming in colon cancer; 7q11.23 copy number variation syndrome; 1p36 copy number variation syndrome; 10q11.21q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)" "Lysine catabolism; Glyoxylate metabolism and glycine degradation; Citric acid cycle (TCA cycle)" "10" "0" "1.033" "0.999" "1.099" "1.026" "1.118" "1.004" "1.040" "0.977" "1.001" "2036.8" "2103.3" "2034.2" "2237.7" "2089.4" "2276.9" "2043.9" "2117.4" "1989.8" "2038.2" "" "" "" "" "" "" "" "" "" "" "1908.5" "1740.4" "1888.5" "1729.8" "1781.0" "2175.3" "1867.6" "1880.0" "1989.8" "1962.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2939496649029224586" "False" "High" "IsMasterProtein" "P51812" "Ribosomal protein S6 kinase alpha-3 OS=Homo sapiens OX=9606 GN=RPS6KA3 PE=1 SV=1" "0.000" "False" "27.303" "13" "10" "12" "4" "740" "83.7" "6.89" "35.93" "10" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00433" "6197" "ENSG00000177189" "RPS6KA3" "B2R9V4; hsa:6197; P51812; Q4VAP3; Q59H26; Q5JPK8; Q7Z3Z7" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Thermogenesis; EGF/EGFR signaling pathway; Cytoplasmic ribosomal proteins; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Macrophage-stimulating protein (MSP) signaling network map" "Senescence-Associated Secretory Phenotype (SASP); Recycling pathway of L1; RSK activation; ERK/MAPK targets; CREB phosphorylation; Gastrin-CREB signalling pathway via PKC and MAPK" "18" "0" "1.075" "1.036" "1.026" "1.058" "1.085" "0.977" "0.986" "0.959" "1.022" "164.3" "176.6" "170.2" "168.6" "173.8" "178.2" "160.5" "162.0" "157.5" "167.9" "" "" "" "" "" "" "" "" "" "" "154.0" "146.1" "158.0" "130.4" "148.1" "170.3" "146.7" "143.8" "157.5" "161.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1749791296604860145" "False" "High" "IsMasterProtein" "Q9BTE6" "Alanyl-tRNA editing protein Aarsd1 OS=Homo sapiens OX=9606 GN=AARSD1 PE=1 SV=2" "0.000" "False" "27.277" "25" "8" "12" "8" "412" "45.5" "6.42" "39.41" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf07973" "100885850; 80755" "ENSG00000108825; ENSG00000266967" "AARSD1" "B4DI73; hsa:100885850; hsa:80755; Q9BTE6" "" "" "0" "0" "1.060" "0.987" "1.043" "1.014" "0.993" "0.991" "0.997" "1.017" "1.007" "1416.7" "1501.4" "1398.2" "1477.4" "1437.0" "1407.4" "1404.3" "1412.2" "1440.9" "1426.6" "" "" "" "" "" "" "" "" "" "" "1327.4" "1242.4" "1298.1" "1142.1" "1224.8" "1344.6" "1283.1" "1253.9" "1440.9" "1373.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5015398897820644174" "False" "High" "IsMasterProtein" "O14757" "Serine/threonine-protein kinase Chk1 OS=Homo sapiens OX=9606 GN=CHEK1 PE=1 SV=2" "0.000" "False" "27.272" "18" "8" "9" "8" "476" "54.4" "8.25" "31.25" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1111" "ENSG00000149554" "CHEK1" "A8K934; B4DDD0; B4DSK3; B5BTY6; F5H7S4; H2BI51; hsa:1111; O14757" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATR signaling; ATM signaling in development and disease ; DNA repair pathways, full network; TROP2 regulatory signaling; DNA damage response" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Transcriptional Regulation by E2F6; Signaling by SCF-KIT; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex" "18" "0" "1.015" "1.054" "1.085" "1.026" "1.002" "0.967" "0.940" "0.988" "1.040" "1717.7" "1744.0" "1810.7" "1863.4" "1762.6" "1721.5" "1661.5" "1614.0" "1697.6" "1787.2" "" "" "" "" "" "" "" "" "" "" "1609.4" "1443.1" "1681.0" "1440.5" "1502.4" "1644.7" "1518.2" "1433.1" "1697.6" "1720.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5185588165699995097" "False" "High" "IsMasterProtein" "P20290" "Transcription factor BTF3 OS=Homo sapiens OX=9606 GN=BTF3 PE=1 SV=1" "0.000" "False" "27.249" "33" "8" "17" "6" "206" "22.2" "9.38" "60.45" "8" "transport;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "" "Pf01849" "689" "ENSG00000145741" "BTF3" "A8K510; hsa:689; P20290; Q13893; Q76M56" "Orexin receptor pathway" "" "1" "2" "1.125" "1.032" "1.035" "1.023" "0.967" "0.914" "0.969" "0.980" "0.966" "2665.8" "2998.8" "2751.2" "2758.8" "2726.9" "2576.9" "2436.9" "2584.2" "2611.2" "2575.1" "" "" "" "" "" "" "" "" "" "" "2497.8" "2481.4" "2554.2" "2132.7" "2324.3" "2462.0" "2226.6" "2294.5" "2611.2" "2479.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8285905538601848760" "False" "High" "IsMasterProtein" "Q9H0E9" "Bromodomain-containing protein 8 OS=Homo sapiens OX=9606 GN=BRD8 PE=1 SV=2" "0.000" "False" "27.240" "7" "9" "16" "9" "1235" "135.3" "4.60" "43.73" "9" "cell organization and biogenesis;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00439" "10902" "ENSG00000112983" "BRD8" "hsa:10902; O43178; Q15355; Q58AB0; Q59GN0; Q969M9; Q9H0E9" "" "HATs acetylate histones" "1" "0" "0.926" "0.940" "0.930" "0.948" "0.988" "0.944" "0.945" "0.917" "0.960" "1525.9" "1412.4" "1434.5" "1419.1" "1446.3" "1507.3" "1439.9" "1441.6" "1399.2" "1464.8" "" "" "" "" "" "" "" "" "" "" "1429.8" "1168.8" "1331.7" "1097.0" "1232.8" "1440.1" "1315.7" "1280.0" "1399.2" "1410.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5073984553663010392" "False" "High" "IsMasterProtein" "Q86UV5" "Ubiquitin carboxyl-terminal hydrolase 48 OS=Homo sapiens OX=9606 GN=USP48 PE=1 SV=1" "0.000" "False" "27.238" "9" "10" "10" "10" "1035" "119.0" "6.05" "25.70" "10" "protein metabolism" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00443, Pf06337" "84196" "ENSG00000090686" "USP48" "B7ZKS7; hsa:84196; Q2M3I4; Q5SZI4; Q5T3T5; Q6NX53; Q86UV5; Q8N3F6; Q96F64; Q96IQ3; Q9H5N3; Q9H5T7; Q9NUJ6; Q9NXR0" "" "Ub-specific processing proteases" "1" "0" "0.924" "0.974" "0.905" "0.964" "0.947" "0.901" "0.933" "0.916" "0.953" "1930.7" "1784.9" "1880.9" "1747.9" "1861.7" "1828.7" "1739.8" "1800.9" "1769.4" "1839.1" "" "" "" "" "" "" "" "" "" "" "1809.0" "1477.0" "1746.1" "1351.2" "1586.8" "1747.1" "1589.7" "1599.0" "1769.4" "1770.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7261913870359179685" "False" "High" "IsMasterProtein" "O75165" "DnaJ homolog subfamily C member 13 OS=Homo sapiens OX=9606 GN=DNAJC13 PE=1 SV=5" "0.000" "False" "27.215" "5" "11" "12" "11" "2243" "254.3" "6.74" "31.98" "11" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf00226, Pf14237, Pf19432" "23317" "ENSG00000138246" "DNAJC13" "hsa:23317; O75165; Q3L0T1; Q6PI82; Q6UJ77; Q6ZSW1; Q6ZUT5; Q86XG3; Q96DC1; Q9BWK9" "" "Neutrophil degranulation" "1" "0" "1.045" "1.058" "1.142" "1.104" "1.058" "1.067" "1.085" "1.022" "1.094" "973.8" "1017.2" "1030.0" "1111.6" "1074.7" "1030.0" "1039.5" "1057.0" "995.4" "1065.1" "" "" "" "" "" "" "" "" "" "" "912.5" "841.8" "956.2" "859.3" "916.1" "984.1" "949.9" "938.5" "995.4" "1025.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6835034816184829460" "False" "High" "IsMasterProtein" "Q13363" "C-terminal-binding protein 1 OS=Homo sapiens OX=9606 GN=CTBP1 PE=1 SV=2" "0.000" "False" "27.211" "20" "9" "14" "5" "440" "47.5" "6.77" "45.23" "9" "protein metabolism;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00389, Pf02826" "1487" "ENSG00000159692" "CTBP1" "Q13363; Q4W5N3; Q7Z2Q5" "Notch signaling; Ectoderm differentiation; Ectoderm differentiation; Wnt signaling pathway; Pathways affected in adenoid cystic carcinoma; Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma" "SUMOylation of transcription cofactors; Deactivation of the beta-catenin transactivating complex; Repression of WNT target genes; Signaling by TCF7L2 mutants" "14" "4" "0.932" "0.878" "0.904" "0.900" "0.957" "0.890" "0.911" "0.924" "0.886" "2857.6" "2662.7" "2509.5" "2583.6" "2572.0" "2736.1" "2544.6" "2602.8" "2641.3" "2530.6" "" "" "" "" "" "" "" "" "" "" "2677.6" "2203.3" "2329.8" "1997.3" "2192.3" "2614.1" "2325.1" "2311.1" "2641.3" "2436.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7858959922113811047" "False" "High" "IsMasterProtein" "Q6ZMI0" "Protein phosphatase 1 regulatory subunit 21 OS=Homo sapiens OX=9606 GN=PPP1R21 PE=1 SV=1" "0.000" "False" "27.199" "12" "9" "9" "9" "780" "88.3" "6.84" "30.41" "9" "" "other cytoplasmic organelle" "" "Pf10205, Pf10212, Pf21636" "129285" "ENSG00000162869" "PPP1R21" "B7ZKY5; B7ZKY7; E1B6W7; hsa:129285; Q2TA78; Q6ZMI0; Q6ZMI6; Q8IW83; Q8J029; Q96ES8" "" "" "0" "0" "1.045" "1.049" "1.081" "1.038" "1.033" "1.016" "1.003" "1.041" "0.991" "637.8" "666.3" "669.3" "689.3" "662.0" "658.6" "648.0" "639.5" "664.1" "632.2" "" "" "" "" "" "" "" "" "" "" "597.6" "551.3" "621.4" "532.9" "564.3" "629.2" "592.1" "567.8" "664.1" "608.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1669697587989024487" "False" "High" "IsMasterProtein" "Q96FW1" "Ubiquitin thioesterase OTUB1 OS=Homo sapiens OX=9606 GN=OTUB1 PE=1 SV=2" "0.000" "False" "27.189" "39" "8" "11" "8" "271" "31.3" "4.94" "38.42" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf10275" "55611" "ENSG00000167770" "OTUB1" "hsa:55611; Q32Q78; Q96FW1; Q96II3; Q9NXQ4; Q9P0B8" "" "Ub-specific processing proteases; Ovarian tumor domain proteases" "2" "0" "0.934" "1.005" "0.885" "0.940" "1.019" "0.911" "0.969" "0.971" "0.967" "1047.6" "978.9" "1053.2" "927.1" "984.5" "1067.8" "954.0" "1014.9" "1016.8" "1012.9" "" "" "" "" "" "" "" "" "" "" "981.6" "810.0" "977.7" "716.7" "839.2" "1020.2" "871.7" "901.1" "1016.8" "975.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7523949865199722082" "False" "High" "IsMasterProtein" "P50579" "Methionine aminopeptidase 2 OS=Homo sapiens OX=9606 GN=METAP2 PE=1 SV=1" "0.000" "False" "27.180" "20" "8" "14" "8" "478" "52.9" "5.82" "54.05" "8" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00557" "10988" "ENSG00000111142" "METAP2" "B2RDI8; B4DUX5; G3XA91; hsa:10988; P50579; Q8NB11" "" "Inactivation, recovery and regulation of the phototransduction cascade" "1" "0" "1.023" "0.978" "0.970" "1.054" "1.043" "0.929" "0.960" "0.908" "0.978" "1690.2" "1728.9" "1653.6" "1640.2" "1781.7" "1762.3" "1570.2" "1621.8" "1535.1" "1653.0" "" "" "" "" "" "" "" "" "" "" "1583.7" "1430.6" "1535.2" "1268.0" "1518.7" "1683.7" "1434.8" "1440.0" "1535.1" "1591.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3509057874585176951" "False" "High" "IsMasterProtein" "Q9GZS1" "DNA-directed RNA polymerase I subunit RPA49 OS=Homo sapiens OX=9606 GN=POLR1E PE=1 SV=3" "0.000" "False" "27.180" "21" "9" "11" "9" "419" "47.2" "8.94" "36.51" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06870" "64425" "ENSG00000137054" "POLR1E" "hsa:64425; Q5VZT3; Q8NBA9; Q96L20; Q9GZS1" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome; Rubinstein-Taybi syndrome 1" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination" "9" "0" "1.062" "1.059" "1.084" "1.074" "1.020" "1.113" "1.095" "1.107" "1.078" "1552.7" "1649.0" "1644.6" "1682.4" "1667.8" "1583.9" "1727.6" "1699.9" "1718.1" "1674.1" "" "" "" "" "" "" "" "" "" "" "1454.9" "1364.5" "1526.8" "1300.6" "1421.6" "1513.2" "1578.5" "1509.4" "1718.1" "1612.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4137720252324409143" "False" "High" "IsMasterProtein" "O60716" "Catenin delta-1 OS=Homo sapiens OX=9606 GN=CTNND1 PE=1 SV=1" "0.000" "False" "27.171" "10" "10" "10" "10" "968" "108.1" "6.23" "31.49" "10" "cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00514" "1500" "ENSG00000198561" "CTNND1" "A8K939; hsa:1500; O15088; O60713; O60714; O60715; O60716; O60935; Q6DHZ7; Q6RBX8; Q9UP71; Q9UP72; Q9UP73" "VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency" "VEGFR2 mediated vascular permeability; Adherens junctions interactions; InlA-mediated entry of Listeria monocytogenes into host cells; Regulation of CDH11 function; Regulation of CDH19 Expression and Function; CDH11 homotypic and heterotypic interactions" "8" "0" "0.974" "0.962" "0.978" "0.963" "1.015" "0.919" "0.879" "0.916" "0.976" "1961.2" "1909.8" "1886.9" "1918.0" "1888.6" "1991.5" "1802.6" "1723.0" "1795.9" "1914.3" "" "" "" "" "" "" "" "" "" "" "1837.7" "1580.3" "1751.8" "1482.7" "1609.8" "1902.7" "1647.1" "1529.8" "1795.9" "1843.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3997402182379015815" "False" "High" "IsMasterProtein" "O15371" "Eukaryotic translation initiation factor 3 subunit D OS=Homo sapiens OX=9606 GN=EIF3D PE=1 SV=1" "0.000" "False" "27.170" "18" "7" "8" "7" "548" "63.9" "6.05" "26.97" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf05091" "8664" "ENSG00000100353" "EIF3D" "A8MWD3; B2R7D4; B4DTF8; B4DVY1; hsa:8664; O15371; Q3MJD9; Q5M9Q6" "Translation factors; VEGFA-VEGFR2 signaling; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "9" "0" "1.011" "1.043" "1.021" "0.992" "0.991" "1.093" "1.178" "1.097" "1.043" "700.1" "708.1" "730.5" "714.7" "694.3" "693.6" "764.9" "824.7" "768.2" "730.3" "" "" "" "" "" "" "" "" "" "" "656.0" "585.9" "678.2" "552.5" "591.8" "662.7" "698.9" "732.3" "768.2" "703.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4992003344612717305" "False" "High" "IsMasterProtein" "P30260" "Cell division cycle protein 27 homolog OS=Homo sapiens OX=9606 GN=CDC27 PE=1 SV=2" "0.000" "False" "27.137" "11" "9" "11" "9" "824" "91.8" "7.02" "38.52" "9" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00515, Pf12895" "996" "ENSG00000004897" "CDC27" "G3V1C4; hsa:996; P30260; Q16349; Q96F35" "Cell cycle; 2q21.1 copy number variation syndrome" "Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "20" "0" "1.026" "0.997" "0.987" "0.995" "0.992" "0.980" "1.000" "0.988" "1.031" "1099.4" "1127.5" "1096.0" "1085.5" "1094.3" "1090.7" "1077.9" "1099.3" "1086.3" "1133.8" "" "" "" "" "" "" "" "" "" "" "1030.2" "933.0" "1017.5" "839.1" "932.8" "1042.1" "984.9" "976.1" "1086.3" "1091.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2874885037648560876" "False" "High" "IsMasterProtein" "O60869" "Endothelial differentiation-related factor 1 OS=Homo sapiens OX=9606 GN=EDF1 PE=1 SV=1" "0.000" "False" "27.119" "45" "9" "15" "9" "148" "16.4" "9.95" "42.52" "9" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01381, Pf08523" "8721" "ENSG00000107223" "EDF1" "hsa:8721; O60869; Q5T5T2; Q9UIM1" "" "" "0" "0" "1.122" "1.114" "1.165" "1.076" "0.973" "1.061" "0.980" "1.081" "1.100" "1023.1" "1148.0" "1139.9" "1192.3" "1100.8" "995.7" "1085.9" "1003.1" "1106.3" "1125.3" "" "" "" "" "" "" "" "" "" "" "958.6" "950.0" "1058.3" "921.7" "938.3" "951.3" "992.2" "890.6" "1106.3" "1083.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9167307694424558965" "False" "High" "IsMasterProtein" "O95336" "6-phosphogluconolactonase OS=Homo sapiens OX=9606 GN=PGLS PE=1 SV=2" "0.000" "False" "27.115" "38" "7" "9" "7" "258" "27.5" "6.05" "33.16" "7" "other metabolic processes" "cytosol" "other molecular function" "Pf01182" "25796" "ENSG00000130313" "PGLS" "hsa:25796; O95336" "Pentose phosphate metabolism" "Pentose phosphate pathway" "2" "0" "1.092" "0.959" "1.263" "1.039" "0.933" "1.131" "1.019" "0.938" "1.004" "1048.9" "1145.1" "1005.4" "1325.0" "1090.1" "978.1" "1186.4" "1068.7" "983.4" "1052.9" "" "" "" "" "" "" "" "" "" "" "982.8" "947.5" "933.4" "1024.3" "929.2" "934.5" "1084.0" "948.9" "983.4" "1013.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7486403724056782188" "False" "High" "IsMasterProtein" "Q7L8L6" "FAST kinase domain-containing protein 5, mitochondrial OS=Homo sapiens OX=9606 GN=FASTKD5 PE=1 SV=1" "0.000" "False" "27.110" "13" "10" "12" "10" "764" "86.5" "8.13" "35.99" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "nucleic acid binding activity" "Pf06743, Pf08368, Pf08373" "60493" "ENSG00000215251" "FASTKD5" "hsa:60493; Q7L8L6; Q96JN3; Q9H5D1; Q9H8Y3" "" "FASTK family proteins regulate processing and stability of mitochondrial RNAs" "1" "0" "1.061" "1.044" "1.044" "1.077" "1.071" "1.034" "1.032" "1.076" "1.070" "1114.0" "1181.6" "1162.9" "1163.1" "1199.7" "1193.6" "1151.5" "1149.8" "1199.2" "1192.4" "" "" "" "" "" "" "" "" "" "" "1043.8" "977.8" "1079.6" "899.1" "1022.6" "1140.4" "1052.1" "1020.9" "1199.2" "1148.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3194956700439507601" "False" "High" "IsMasterProtein" "Q9UPT5" "Exocyst complex component 7 OS=Homo sapiens OX=9606 GN=EXOC7 PE=1 SV=3" "0.000" "False" "27.101" "14" "10" "11" "10" "735" "83.3" "6.79" "30.41" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf03081, Pf20669" "23265" "ENSG00000182473" "EXOC7" "B5MC69; B8XXP2; hsa:23265; Q8ND93; Q8WV91; Q96FF0; Q9H8C3; Q9H9X3; Q9HA32; Q9UPT5" "Angiopoietin-like protein 8 regulatory pathway; Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "5" "0" "1.033" "1.038" "1.056" "1.050" "0.979" "0.990" "0.963" "0.990" "1.025" "1887.3" "1949.3" "1958.6" "1992.9" "1982.1" "1848.5" "1867.8" "1817.6" "1869.3" "1934.5" "" "" "" "" "" "" "" "" "" "" "1768.4" "1613.0" "1818.3" "1540.6" "1689.5" "1766.1" "1706.6" "1613.8" "1869.3" "1862.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3391234540397172253" "False" "High" "IsMasterProtein" "Q9H2U1" "ATP-dependent DNA/RNA helicase DHX36 OS=Homo sapiens OX=9606 GN=DHX36 PE=1 SV=2" "0.000" "False" "27.095" "10" "9" "14" "8" "1008" "114.7" "7.68" "32.47" "9" "cell organization and biogenesis;RNA metabolism OR transcription;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "170506" "ENSG00000174953" "DHX36" "B2RB00; hsa:170506; Q70JU3; Q8IYE5; Q9H2U1; Q9P240" "VEGFA-VEGFR2 signaling" "DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "2" "0" "0.924" "0.962" "0.945" "0.962" "0.977" "0.959" "1.002" "0.922" "0.963" "811.9" "750.4" "780.7" "766.9" "780.8" "793.1" "778.3" "813.8" "748.3" "781.8" "" "" "" "" "" "" "" "" "" "" "760.8" "620.9" "724.8" "592.9" "665.5" "757.7" "711.1" "722.6" "748.3" "752.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516801179277526941" "False" "High" "IsMasterProtein" "Q9HB71" "Calcyclin-binding protein OS=Homo sapiens OX=9606 GN=CACYBP PE=1 SV=2" "0.000" "False" "27.051" "31" "8" "17" "8" "228" "26.2" "8.25" "49.80" "8" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf04969, Pf05002, Pf09032" "27101" "ENSG00000116161" "CACYBP" "B2ZWH2; B3KSF1; hsa:27101; O60666; Q5R370; Q5R371; Q9HB71" "Gastric cancer network 2" "" "1" "0" "1.485" "1.053" "1.147" "1.112" "1.014" "0.975" "1.083" "1.371" "1.148" "1042.6" "1548.6" "1097.9" "1195.8" "1159.6" "1057.6" "1016.3" "1128.8" "1429.4" "1196.9" "" "" "" "" "" "" "" "" "" "" "976.9" "1281.5" "1019.3" "924.4" "988.4" "1010.4" "928.6" "1002.3" "1429.4" "1152.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3695950193153579401" "False" "High" "IsMasterProtein" "Q6VEQ5" "WAS protein family homolog 2 OS=Homo sapiens OX=9606 GN=WASH2P PE=2 SV=2" "0.000" "False" "27.048" "20" "9" "12" "9" "465" "50.3" "5.71" "37.61" "9" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf11945" "" "" "WASH2P" "Q6VEQ5" "" "" "0" "0" "0.986" "1.017" "1.028" "1.027" "0.966" "0.969" "1.001" "1.005" "0.995" "1407.8" "1388.5" "1431.8" "1446.9" "1445.8" "1360.4" "1364.9" "1408.8" "1414.9" "1400.8" "" "" "" "" "" "" "" "" "" "" "1319.1" "1149.0" "1329.2" "1118.5" "1232.3" "1299.7" "1247.1" "1250.9" "1414.9" "1348.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5964794776079938030" "False" "High" "IsMasterProtein" "P56537" "Eukaryotic translation initiation factor 6 OS=Homo sapiens OX=9606 GN=EIF6 PE=1 SV=1" "0.000" "False" "27.045" "45" "7" "10" "7" "245" "26.6" "4.68" "34.44" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01912" "3692" "ENSG00000242372" "EIF6" "B7ZBG9; hsa:3692; P56537; Q6IBN8; Q96TD5" "Translation factors; Genetic causes of porto-sinusoidal vascular disease" "" "2" "0" "1.049" "1.020" "1.262" "1.185" "1.099" "1.112" "1.102" "1.121" "1.075" "378.4" "397.1" "385.8" "477.6" "448.3" "415.8" "420.6" "416.8" "424.2" "406.7" "" "" "" "" "" "" "" "" "" "" "354.5" "328.6" "358.1" "369.2" "382.2" "397.3" "384.3" "370.1" "424.2" "391.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1585562482268553685" "False" "High" "IsMasterProtein" "O15372" "Eukaryotic translation initiation factor 3 subunit H OS=Homo sapiens OX=9606 GN=EIF3H PE=1 SV=1" "0.000" "False" "27.040" "22" "7" "11" "7" "352" "39.9" "6.54" "40.13" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf19445" "8667" "ENSG00000147677" "EIF3H" "hsa:8667; O15372" "Translation factors; VEGFA-VEGFR2 signaling; Measles virus infection; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "10" "0" "0.960" "1.007" "0.880" "0.873" "0.849" "1.055" "1.079" "1.089" "0.967" "2262.8" "2172.6" "2278.7" "1990.7" "1975.2" "1921.5" "2386.1" "2441.8" "2464.4" "2187.5" "" "" "" "" "" "" "" "" "" "" "2120.2" "1797.8" "2115.5" "1538.9" "1683.6" "1835.8" "2180.3" "2168.1" "2464.4" "2106.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-996241339141020167" "False" "High" "IsMasterProtein" "Q96SB8" "Structural maintenance of chromosomes protein 6 OS=Homo sapiens OX=9606 GN=SMC6 PE=1 SV=2" "0.000" "False" "27.036" "9" "9" "11" "9" "1091" "126.2" "6.99" "25.48" "9" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13476" "79677" "ENSG00000163029" "SMC6" "A8K8Q6; D6W518; hsa:79677; Q05BV4; Q96SB8; Q9H0X3; Q9H6M0" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "1.072" "1.065" "1.051" "1.138" "1.086" "1.121" "1.106" "1.068" "1.087" "665.0" "713.0" "708.0" "699.0" "756.6" "722.4" "745.3" "735.2" "710.2" "722.7" "" "" "" "" "" "" "" "" "" "" "623.1" "590.0" "657.3" "540.4" "644.9" "690.2" "681.0" "652.8" "710.2" "695.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9215017324203505863" "False" "High" "IsMasterProtein" "Q6Y7W6" "GRB10-interacting GYF protein 2 OS=Homo sapiens OX=9606 GN=GIGYF2 PE=1 SV=1" "0.000" "False" "27.033" "8" "9" "12" "9" "1299" "150.0" "5.54" "35.43" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02213" "26058" "ENSG00000204120" "GIGYF2" "A6H8W4; B9EG55; E9PBB0; hsa:26058; O75137; Q6Y7W6; Q7Z2Z8; Q7Z3I2; Q96HU4; Q9NV82" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.045" "0.990" "1.040" "0.999" "0.988" "1.087" "1.100" "1.015" "1.041" "1176.3" "1228.9" "1164.9" "1223.8" "1174.7" "1162.7" "1278.2" "1294.1" "1193.5" "1225.0" "" "" "" "" "" "" "" "" "" "" "1102.1" "1016.9" "1081.5" "946.0" "1001.3" "1110.8" "1167.9" "1149.1" "1193.5" "1179.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8950408743700017704" "False" "High" "IsMasterProtein" "O60645" "Exocyst complex component 3 OS=Homo sapiens OX=9606 GN=EXOC3 PE=1 SV=3" "0.000" "False" "27.028" "12" "9" "10" "9" "745" "85.5" "6.29" "38.17" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf06046" "11336" "ENSG00000180104" "EXOC3" "hsa:11336; O60645; Q6P2E8; Q8TEN6; Q8WUW0; Q96DI4" "Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "4" "0" "1.001" "1.035" "1.036" "1.034" "1.017" "0.971" "0.969" "0.966" "1.056" "1569.5" "1570.9" "1625.1" "1625.3" "1623.6" "1595.5" "1524.5" "1520.7" "1516.5" "1657.9" "" "" "" "" "" "" "" "" "" "" "1470.7" "1299.9" "1508.7" "1256.4" "1383.9" "1524.4" "1393.0" "1350.3" "1516.5" "1596.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1749149961980637251" "False" "High" "IsMasterProtein" "P27361" "Mitogen-activated protein kinase 3 OS=Homo sapiens OX=9606 GN=MAPK3 PE=1 SV=4" "0.000" "False" "27.019" "22" "10" "13" "6" "379" "43.1" "6.74" "39.85" "10" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069" "5595" "ENSG00000102882" "MAPK3" "A8CZ58; B0LPG3; hsa:5595; P27361; Q8NHX1" "IL-5 signaling pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; PDGF pathway; Polycystic kidney disease pathway; S1P receptor signal transduction; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; IL-3 signaling pathway; TCA cycle nutrient use and invasiveness of ovarian cancer; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; Prion disease pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Neovascularization processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; Bile acids synthesis and enterohepatic circulation ; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Regulatory circuits of the STAT3 signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; CAMKK2 pathway; Disruption of postsynaptic signaling by CNV; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; 2q11.2 copy number variation syndrome; Comprehensive IL-17A signaling; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; 8p23.1 copy number variation syndrome; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; Osteoarthritic chondrocyte hypertrophy; NPHP1 deletion syndrome; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; TGF-beta receptor signaling; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "Oxidative Stress Induced Senescence; Oncogene Induced Senescence; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Regulation of PTEN gene transcription; Interferon gamma signaling; ISG15 antiviral mechanism; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCGR3A-mediated phagocytosis; NPAS4 regulates expression of target genes; RHO GTPases Activate WASPs and WAVEs; Regulation of HSF1-mediated heat shock response; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); Signaling by NODAL; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Senescence-Associated Secretory Phenotype (SASP); Growth hormone receptor signaling; Regulation of the apoptosome activity; Signal transduction by L1; NCAM signaling for neurite out-growth; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RUNX2 regulates osteoblast differentiation; RSK activation; Spry regulation of FGF signaling; Suppression of apoptosis; MAPK3 (ERK1) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; IFNG signaling activates MAPKs; RNA Polymerase I Promoter Opening; Signaling by Activin; Activation of the AP-1 family of transcription factors; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Signal attenuation; Gastrin-CREB signalling pathway via PKC and MAPK; ESR-mediated signaling; Negative feedback regulation of MAPK pathway; Advanced glycosylation endproduct receptor signaling; RHO GTPases Activate NADPH Oxidases; Nuclear events stimulated by ALK signaling in cancer; ERKs are inactivated; Signaling by MAP2K mutants" "178" "1" "0.985" "0.957" "1.000" "0.984" "0.982" "0.934" "0.961" "0.961" "1.008" "1492.6" "1469.9" "1428.6" "1492.2" "1468.0" "1466.0" "1394.2" "1435.0" "1434.0" "1504.1" "" "" "" "" "" "" "" "" "" "" "1398.5" "1216.3" "1326.3" "1153.6" "1251.3" "1400.6" "1273.9" "1274.1" "1434.0" "1448.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3968134916858178565" "False" "High" "IsMasterProtein" "P61247" "Small ribosomal subunit protein eS1 OS=Homo sapiens OX=9606 GN=RPS3A PE=1 SV=2" "0.000" "False" "27.007" "32" "9" "13" "9" "264" "29.9" "9.73" "32.88" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01015" "6189" "ENSG00000145425; ENSG00000292158" "RPS3A" "B2R4D4; D3DP05; hsa:6189; P33443; P49241; P61247" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.028" "1.050" "0.962" "1.062" "0.989" "1.057" "1.074" "1.065" "1.042" "1650.1" "1696.8" "1733.0" "1587.9" "1752.6" "1631.6" "1743.4" "1771.4" "1758.0" "1719.9" "" "" "" "" "" "" "" "" "" "" "1546.1" "1404.1" "1608.8" "1227.5" "1493.9" "1558.9" "1593.0" "1572.8" "1758.0" "1656.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2868911152044451366" "False" "High" "IsMasterProtein" "Q99570" "Phosphoinositide 3-kinase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PIK3R4 PE=1 SV=3" "0.000" "False" "27.005" "6" "9" "14" "9" "1358" "153.0" "7.17" "33.49" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00400" "30849" "ENSG00000196455" "PIK3R4" "hsa:30849; Q2TBF4; Q99570" "Alzheimer's disease and miRNA effects; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neural crest cell migration during development; Neural crest cell migration in cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Osteoblast differentiation and related diseases; Ciliopathies; Insulin signaling; Autophagy; Regulation of actin cytoskeleton; Alzheimer's disease; ADHD and autism (ASD) linked metabolic pathways and SNP; DNA damage response (only ATM dependent)" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; PI3K Cascade; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; RHO GTPases Activate NADPH Oxidases; Toll Like Receptor 9 (TLR9) Cascade" "25" "0" "1.045" "0.922" "1.029" "0.970" "1.024" "0.961" "0.954" "0.970" "0.962" "934.5" "977.0" "862.0" "961.3" "906.8" "957.2" "897.7" "891.3" "906.6" "899.3" "" "" "" "" "" "" "" "" "" "" "875.6" "808.4" "800.3" "743.1" "772.9" "914.5" "820.3" "791.4" "906.6" "865.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8173179408617438185" "False" "High" "IsMasterProtein" "P32929" "Cystathionine gamma-lyase OS=Homo sapiens OX=9606 GN=CTH PE=1 SV=3" "0.000" "False" "26.935" "19" "7" "11" "7" "405" "44.5" "6.70" "35.79" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01053" "1491" "ENSG00000116761" "CTH" "B4E1R2; E9PDV0; hsa:1491; P32929; Q53FB3; Q53Y79; Q9H4W7; Q9H4W8" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways; Methionine metabolism leading to sulfur amino acids and related disorders; Ferroptosis" "Degradation of cysteine and homocysteine; Metabolism of ingested SeMet, Sec, MeSec into H2Se; Cysteine formation from homocysteine" "12" "0" "1.036" "1.046" "1.127" "1.079" "1.106" "1.029" "1.062" "1.029" "1.082" "426.3" "441.7" "446.0" "480.5" "460.1" "471.7" "438.7" "452.9" "438.5" "461.1" "" "" "" "" "" "" "" "" "" "" "399.4" "365.5" "414.1" "371.4" "392.2" "450.6" "400.8" "402.1" "438.5" "444.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2857975298597403350" "False" "High" "IsMasterProtein" "Q96N67" "Dedicator of cytokinesis protein 7 OS=Homo sapiens OX=9606 GN=DOCK7 PE=1 SV=4" "0.000" "False" "26.910" "5" "11" "11" "10" "2140" "242.4" "6.80" "32.10" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "85440" "ENSG00000116641" "DOCK7" "hsa:85440; Q00M63; Q2PPY7; Q45RE8; Q45RE9; Q5T1B9; Q5T1C0; Q6ZV32; Q8TB82; Q96N67; Q96NG6; Q96NI0; Q9C092" "" "Factors involved in megakaryocyte development and platelet production; CDC42 GTPase cycle; RAC1 GTPase cycle; MET activates RAP1 and RAC1" "4" "0" "1.010" "1.030" "1.034" "1.035" "1.022" "1.055" "1.096" "1.041" "1.056" "1294.2" "1306.8" "1333.7" "1338.4" "1339.1" "1322.2" "1365.4" "1419.0" "1347.9" "1367.3" "" "" "" "" "" "" "" "" "" "" "1212.7" "1081.3" "1238.2" "1034.7" "1141.4" "1263.2" "1247.6" "1260.0" "1347.9" "1316.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1377635877244790923" "False" "High" "IsMasterProtein" "P36873" "Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CC PE=1 SV=1" "0.000" "False" "26.906" "28" "8" "11" "2" "323" "37.0" "6.54" "33.66" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5501" "ENSG00000186298" "PPP1CC" "hsa:5501; P36873" "Common pathways underlying drug addiction; Focal adhesion; Hippo-Merlin signaling dysregulation; Neuroinflammation and glutamatergic signaling" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Triglyceride catabolism; Circadian Clock; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins" "17" "0" "1.052" "1.039" "1.171" "1.067" "1.068" "1.151" "1.101" "1.079" "1.042" "459.5" "483.6" "477.3" "538.2" "490.4" "490.9" "529.1" "505.9" "495.7" "478.8" "" "" "" "" "" "" "" "" "" "" "430.6" "400.2" "443.1" "416.1" "418.0" "469.0" "483.4" "449.2" "495.7" "461.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5999519850232784779" "False" "High" "IsMasterProtein" "Q9Y3L3" "SH3 domain-binding protein 1 OS=Homo sapiens OX=9606 GN=SH3BP1 PE=1 SV=3" "0.000" "False" "26.903" "13" "9" "9" "9" "701" "75.7" "6.77" "30.09" "9" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00620, Pf03114" "23616" "ENSG00000100092" "SH3BP1" "hsa:23616; Q5R3N0; Q6IBZ2; Q6ZVL9; Q96HQ5; Q9NSQ9; Q9Y3L3" "" "RAC1 GTPase cycle" "1" "0" "0.991" "0.987" "1.015" "0.989" "0.997" "0.927" "0.934" "0.965" "0.998" "1635.8" "1620.8" "1614.2" "1659.8" "1617.9" "1630.7" "1517.0" "1528.3" "1578.2" "1631.8" "" "" "" "" "" "" "" "" "" "" "1532.7" "1341.2" "1498.6" "1283.1" "1379.1" "1558.0" "1386.2" "1357.0" "1578.2" "1571.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2644989191906863874" "False" "High" "IsMasterProtein" "Q6ZSZ5" "Rho guanine nucleotide exchange factor 18 OS=Homo sapiens OX=9606 GN=ARHGEF18 PE=1 SV=4" "0.000" "False" "26.888" "8" "9" "11" "9" "1361" "151.5" "6.33" "37.31" "9" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00621, Pf17838" "23370" "ENSG00000104880" "ARHGEF18" "A8MV62; B5ME81; hsa:23370; I3L1I5; O60274; Q6DD92; Q6ZSZ5" "" "G alpha (12/13) signalling events; RHOA GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)" "5" "0" "1.054" "0.998" "1.079" "1.064" "1.029" "1.081" "1.022" "1.122" "1.056" "298.2" "314.1" "297.6" "321.8" "317.2" "306.9" "322.5" "304.8" "334.5" "315.0" "" "" "" "" "" "" "" "" "" "" "279.4" "259.9" "276.3" "248.8" "270.4" "293.2" "294.6" "270.6" "334.5" "303.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3725615404801325538" "False" "High" "IsMasterProtein" "Q9UJX3" "Anaphase-promoting complex subunit 7 OS=Homo sapiens OX=9606 GN=ANAPC7 PE=1 SV=5" "0.000" "False" "26.884" "16" "9" "9" "9" "565" "63.1" "5.72" "29.31" "9" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf13181" "" "ENSG00000196510" "ANAPC7" "Q96AC4; Q96GF4; Q9BU24; Q9NT16; Q9UJX3" "Cell cycle" "Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Inactivation of APC/C via direct inhibition of the APC/C complex; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "1.034" "1.004" "1.027" "1.002" "0.939" "0.917" "0.890" "0.936" "0.970" "1008.5" "1042.6" "1012.9" "1036.0" "1010.0" "946.8" "925.1" "897.4" "943.5" "977.8" "" "" "" "" "" "" "" "" "" "" "944.9" "862.7" "940.4" "800.9" "860.9" "904.6" "845.3" "796.8" "943.5" "941.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8024352083789976777" "False" "High" "IsMasterProtein" "Q9UKV3" "Apoptotic chromatin condensation inducer in the nucleus OS=Homo sapiens OX=9606 GN=ACIN1 PE=1 SV=2" "0.000" "False" "26.873" "6" "9" "14" "9" "1341" "151.8" "6.43" "50.15" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf16294" "22985" "ENSG00000100813" "ACIN1" "B2RTT4; D3DS45; hsa:22985; O75158; Q9UG91; Q9UKV1; Q9UKV2; Q9UKV3" "" "mRNA Splicing - Major Pathway; Apoptotic cleavage of cellular proteins" "2" "0" "1.035" "0.974" "0.986" "1.036" "1.014" "1.555" "1.477" "1.456" "1.145" "1584.6" "1639.7" "1542.7" "1562.4" "1641.6" "1606.6" "2464.4" "2340.4" "2307.7" "1813.7" "" "" "" "" "" "" "" "" "" "" "1484.8" "1356.9" "1432.2" "1207.8" "1399.3" "1535.0" "2251.8" "2078.0" "2307.7" "1746.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6717857941727919032" "False" "High" "IsMasterProtein" "Q8WZA9" "Immunity-related GTPase family Q protein OS=Homo sapiens OX=9606 GN=IRGQ PE=1 SV=1" "0.000" "False" "26.864" "15" "7" "9" "7" "623" "62.7" "4.88" "33.04" "7" "" "" "other molecular function" "" "126298" "ENSG00000167378" "IRGQ" "B2RNP3; hsa:126298; Q8WZA9" "" "" "0" "0" "0.971" "0.964" "1.022" "1.038" "1.018" "0.957" "1.005" "0.935" "1.014" "364.3" "353.7" "351.0" "372.1" "378.3" "370.7" "348.7" "366.2" "340.6" "369.5" "" "" "" "" "" "" "" "" "" "" "341.3" "292.7" "325.9" "287.7" "322.4" "354.2" "318.6" "325.1" "340.6" "355.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-453379581051164535" "False" "High" "IsMasterProtein" "P30086" "Phosphatidylethanolamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PEBP1 PE=1 SV=3" "0.000" "False" "26.849" "40" "6" "18" "6" "187" "21.0" "7.53" "68.36" "6" "other biological processes" "cytosol" "enzyme regulator activity;other molecular function" "Pf01161" "5037" "ENSG00000089220" "PEBP1" "B2R4S1; hsa:5037; P30086" "Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "9" "0" "0.991" "0.986" "0.940" "0.974" "0.925" "0.936" "0.948" "0.915" "0.939" "2499.9" "2478.3" "2464.1" "2349.7" "2434.2" "2312.9" "2340.5" "2370.6" "2286.5" "2347.4" "" "" "" "" "" "" "" "" "" "" "2342.4" "2050.8" "2287.6" "1816.4" "2074.8" "2209.8" "2138.6" "2104.8" "2286.5" "2260.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6915222884888566270" "False" "High" "IsMasterProtein" "O15020" "Spectrin beta chain, non-erythrocytic 2 OS=Homo sapiens OX=9606 GN=SPTBN2 PE=1 SV=3" "0.000" "False" "26.846" "4" "10" "10" "3" "2390" "271.2" "6.11" "28.71" "10" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf15410" "6712" "ENSG00000173898" "SPTBN2" "hsa:6712; O14872; O14873; O15020" "" "MHC class II antigen presentation; COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5541233720560719878" "False" "High" "IsMasterProtein" "O43809" "Cleavage and polyadenylation specificity factor subunit 5 OS=Homo sapiens OX=9606 GN=NUDT21 PE=1 SV=1" "0.000" "False" "26.839" "38" "9" "13" "9" "227" "26.2" "8.82" "41.59" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13869" "11051" "ENSG00000167005" "NUDT21" "hsa:11051; O43809; Q6IB85; Q6NE84" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.021" "1.009" "1.175" "1.094" "1.221" "1.109" "1.175" "1.138" "1.047" "1028.8" "1050.7" "1038.3" "1208.9" "1126.0" "1255.9" "1141.3" "1209.1" "1171.3" "1077.0" "" "" "" "" "" "" "" "" "" "" "964.0" "869.5" "963.9" "934.6" "959.8" "1199.9" "1042.9" "1073.6" "1171.3" "1037.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8625862126903742140" "False" "High" "IsMasterProtein" "P48556" "26S proteasome non-ATPase regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMD8 PE=1 SV=2" "0.000" "False" "26.814" "23" "10" "13" "10" "350" "39.6" "9.70" "42.68" "10" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf10075" "5714" "ENSG00000099341" "PSMD8" "B4DX18; hsa:5714; P48556; Q6P1L7" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "0.970" "0.981" "1.001" "0.973" "0.992" "0.947" "0.994" "0.974" "0.979" "1725.0" "1673.9" "1692.2" "1727.3" "1679.0" "1711.6" "1634.2" "1714.6" "1679.6" "1689.1" "" "" "" "" "" "" "" "" "" "" "1616.3" "1385.1" "1571.0" "1335.3" "1431.1" "1635.3" "1493.3" "1522.4" "1679.6" "1626.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "306109377846906281" "False" "High" "IsMasterProtein" "P49247" "Ribose-5-phosphate isomerase OS=Homo sapiens OX=9606 GN=RPIA PE=1 SV=3" "0.000" "False" "26.811" "31" "8" "14" "8" "311" "33.2" "8.54" "40.88" "8" "other metabolic processes" "cytosol" "other molecular function" "Pf06026" "22934" "ENSG00000153574" "RPIA" "hsa:22934; P49247; Q541P9; Q96BJ6" "Pentose phosphate metabolism; Metabolic reprogramming in colon cancer; Pentose phosphate pathway in senescent cells" "Pentose phosphate pathway; RPIA deficiency: failed conversion of R5P to RU5P; RPIA deficiency: failed conversion of RU5P to R5P" "6" "0" "1.028" "0.961" "1.157" "0.974" "1.019" "1.002" "0.969" "0.923" "0.967" "1258.8" "1294.1" "1209.1" "1456.9" "1225.9" "1282.6" "1261.2" "1219.5" "1161.3" "1216.9" "" "" "" "" "" "" "" "" "" "" "1179.5" "1070.8" "1122.5" "1126.3" "1045.0" "1225.4" "1152.4" "1082.8" "1161.3" "1171.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4424001123554839232" "False" "High" "IsMasterProtein" "Q96CW1" "AP-2 complex subunit mu OS=Homo sapiens OX=9606 GN=AP2M1 PE=1 SV=2" "0.000" "False" "26.796" "22" "11" "15" "11" "435" "49.6" "9.54" "34.90" "11" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00928, Pf01217" "1173" "ENSG00000161203" "AP2M1" "A6NE12; D3DNT1; hsa:1173; P20172; P53679; Q96CW1" "Synaptic vesicle pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; GDNF signaling" "Potential therapeutics for SARS; Recycling pathway of L1; MHC class II antigen presentation; VLDLR internalisation and degradation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Nef mediated downregulation of CD28 cell surface expression; Formation of annular gap junctions" "21" "0" "0.965" "1.042" "1.031" "0.983" "1.006" "0.994" "1.040" "0.994" "1.023" "1660.2" "1601.4" "1729.4" "1711.5" "1632.8" "1670.3" "1650.1" "1727.3" "1650.9" "1697.9" "" "" "" "" "" "" "" "" "" "" "1555.6" "1325.1" "1605.5" "1323.1" "1391.8" "1595.8" "1507.8" "1533.7" "1650.9" "1634.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-496325283526098650" "False" "High" "IsMasterProtein" "O75427" "Leucine-rich repeat and calponin homology domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LRCH4 PE=1 SV=2" "0.000" "False" "26.792" "16" "8" "9" "8" "683" "73.4" "8.22" "33.46" "8" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus" "" "Pf00307, Pf13855" "4034" "ENSG00000077454" "LRCH4" "A4D2D5; hsa:4034; O75427; Q8WV85; Q96ID0" "" "" "0" "0" "1.042" "1.040" "1.089" "1.107" "1.058" "1.042" "1.049" "1.065" "1.051" "689.6" "718.6" "717.0" "750.7" "763.5" "729.8" "718.7" "723.7" "734.3" "724.8" "" "" "" "" "" "" "" "" "" "" "646.1" "594.7" "665.7" "580.3" "650.8" "697.2" "656.7" "642.5" "734.3" "697.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6209519133895389976" "False" "High" "IsMasterProtein" "Q9P107" "GEM-interacting protein OS=Homo sapiens OX=9606 GN=GMIP PE=1 SV=2" "0.000" "False" "26.789" "10" "9" "10" "9" "970" "106.6" "5.72" "29.22" "9" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf00620" "51291" "ENSG00000089639" "GMIP" "A0AVN9; B7ZLZ0; hsa:51291; Q9P107" "" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOA GTPase cycle" "3" "0" "1.073" "0.962" "1.155" "0.989" "0.976" "1.112" "0.987" "1.033" "0.958" "200.9" "215.6" "193.2" "232.0" "198.7" "196.0" "223.4" "198.3" "207.5" "192.5" "" "" "" "" "" "" "" "" "" "" "188.2" "178.4" "179.4" "179.3" "169.4" "187.3" "204.1" "176.1" "207.5" "185.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6653202710982051878" "False" "High" "IsMasterProtein" "Q96RL1" "BRCA1-A complex subunit RAP80 OS=Homo sapiens OX=9606 GN=UIMC1 PE=1 SV=2" "0.000" "False" "26.755" "13" "10" "11" "10" "719" "79.7" "5.45" "35.52" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf18282" "51720" "ENSG00000087206" "UIMC1" "A8MSA1; B3KMZ1; B4E3N2; hsa:51720; Q5XKQ1; Q7Z3W7; Q8N5B9; Q96RL1; Q9BZR1; Q9BZR5; Q9UHX7" "5q35 copy number variation" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs" "6" "0" "1.105" "0.999" "1.005" "1.028" "1.036" "1.059" "0.942" "1.034" "1.034" "1706.5" "1884.9" "1705.3" "1715.5" "1753.7" "1767.7" "1807.7" "1608.1" "1765.2" "1764.4" "" "" "" "" "" "" "" "" "" "" "1599.0" "1559.8" "1583.2" "1326.2" "1494.8" "1688.9" "1651.8" "1427.9" "1765.2" "1698.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2739049111137792080" "False" "High" "IsMasterProtein" "P13861" "cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR2A PE=1 SV=2" "0.000" "False" "26.755" "21" "8" "8" "8" "404" "45.5" "5.07" "31.52" "8" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5576" "ENSG00000114302" "PRKAR2A" "hsa:5576; P13861; Q16823; Q9BUB1" "Myometrial relaxation and contraction pathways; G protein signaling pathways; TGF-beta signaling pathway; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; GDNF signaling; Calcium regulation in cardiac cells; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; ROBO receptors bind AKAP5" "22" "0" "0.986" "1.012" "0.995" "1.010" "1.034" "1.013" "1.010" "1.023" "1.033" "1788.4" "1763.0" "1809.5" "1780.2" "1805.9" "1849.5" "1811.6" "1805.8" "1830.1" "1846.7" "" "" "" "" "" "" "" "" "" "" "1675.7" "1458.8" "1679.9" "1376.2" "1539.3" "1767.1" "1655.3" "1603.4" "1830.1" "1778.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7375658416039081200" "False" "High" "IsMasterProtein" "Q9GZU8" "PSME3-interacting protein OS=Homo sapiens OX=9606 GN=PSME3IP1 PE=1 SV=1" "0.000" "False" "26.751" "31" "9" "13" "9" "254" "28.9" "5.45" "45.65" "9" "other biological processes" "nucleus;other cell component" "" "Pf10187" "80011" "ENSG00000172775" "PSME3IP1" "hsa:80011; Q9GZU8" "" "" "0" "0" "1.060" "0.975" "0.980" "0.950" "0.950" "0.952" "0.925" "0.922" "0.960" "1818.6" "1927.4" "1773.8" "1782.0" "1727.1" "1726.9" "1732.2" "1682.3" "1677.6" "1745.9" "" "" "" "" "" "" "" "" "" "" "1704.1" "1594.9" "1646.7" "1377.6" "1472.1" "1649.9" "1582.8" "1493.7" "1677.6" "1681.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4516016884332694472" "False" "High" "IsMasterProtein" "O60361" "Putative nucleoside diphosphate kinase OS=Homo sapiens OX=9606 GN=NME2P1 PE=5 SV=1" "0.000" "False" "26.697" "53" "7" "27" "1" "137" "15.5" "8.57" "84.32" "7" "other metabolic processes;other biological processes" "" "kinase activity;other molecular function" "Pf00334" "" "" "NME2P1" "O60361" "" "Interconversion of nucleotide di- and triphosphates" "1" "0" "0.901" "1.047" "0.929" "1.035" "1.011" "0.935" "1.083" "1.028" "0.987" "252.4" "227.5" "264.3" "234.4" "261.4" "255.2" "236.1" "273.5" "259.5" "249.1" "" "" "" "" "" "" "" "" "" "" "236.5" "188.3" "245.3" "181.2" "222.8" "243.8" "215.8" "242.8" "259.5" "239.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6101901840121098087" "False" "High" "IsMasterProtein" "P52788" "Spermine synthase OS=Homo sapiens OX=9606 GN=SMS PE=1 SV=2" "0.000" "False" "26.687" "23" "9" "13" "9" "366" "41.2" "5.02" "41.26" "9" "other metabolic processes" "cytosol" "other molecular function" "Pf01564, Pf17284, Pf17950" "6611" "ENSG00000102172" "SMS" "A6NHA7; A6NI34; B2R9M0; hsa:6611; O00544; P52788; Q9UQS1" "Methionine de novo and salvage pathway; Amino acid metabolism" "Metabolism of polyamines" "3" "0" "0.906" "0.972" "0.982" "0.973" "0.941" "0.932" "0.956" "0.929" "0.944" "1871.0" "1695.7" "1819.5" "1838.2" "1821.5" "1760.0" "1743.3" "1788.7" "1738.4" "1766.6" "" "" "" "" "" "" "" "" "" "" "1753.2" "1403.2" "1689.2" "1421.0" "1552.6" "1681.5" "1592.9" "1588.2" "1738.4" "1701.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "201437280160465728" "False" "High" "IsMasterProtein" "Q9H9E3" "Conserved oligomeric Golgi complex subunit 4 OS=Homo sapiens OX=9606 GN=COG4 PE=1 SV=3" "0.000" "False" "26.680" "13" "9" "10" "8" "785" "89.0" "5.19" "27.84" "9" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf08318, Pf20662, Pf20663" "25839" "ENSG00000103051" "COG4" "B4DMN8; C9JS23; hsa:25839; Q96D40; Q9BRF0; Q9BVZ2; Q9H5Y4; Q9H9E3; Q9Y3W3" "" "Retrograde transport at the Trans-Golgi-Network; COPI-mediated anterograde transport; Intra-Golgi traffic" "3" "1" "1.012" "0.960" "0.987" "1.045" "1.016" "0.939" "0.944" "1.034" "1.002" "884.6" "895.3" "849.1" "873.1" "924.6" "898.4" "830.7" "835.3" "914.2" "886.4" "" "" "" "" "" "" "" "" "" "" "828.8" "740.8" "788.3" "674.9" "788.1" "858.4" "759.0" "741.6" "914.2" "853.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4012099030302879857" "False" "High" "IsMasterProtein" "P49137" "MAP kinase-activated protein kinase 2 OS=Homo sapiens OX=9606 GN=MAPKAPK2 PE=1 SV=1" "0.000" "False" "26.674" "20" "9" "11" "6" "400" "45.5" "8.68" "40.14" "9" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "9261" "ENSG00000162889" "MAPKAPK2" "hsa:9261; P49137; Q5SY30; Q5SY41; Q8IYD6" "IL-1 signaling pathway; Microtubule cytoskeleton regulation; Interleukin-1 (IL-1) structural pathway; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; VEGFA-VEGFR2 signaling; p38 MAPK signaling pathway; Pleural mesothelioma; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling" "Oxidative Stress Induced Senescence; VEGFA-VEGFR2 Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TNFR1 signaling; p38MAPK events; activated TAK1 mediates p38 MAPK activation; CREB phosphorylation; Synthesis of Leukotrienes (LT) and Eoxins (EX); Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "21" "3" "0.984" "1.001" "0.909" "0.954" "1.002" "0.829" "0.895" "0.957" "0.983" "2988.0" "2939.8" "2989.5" "2715.1" "2850.4" "2995.4" "2476.9" "2675.6" "2860.0" "2938.1" "" "" "" "" "" "" "" "" "" "" "2799.8" "2432.6" "2775.4" "2098.9" "2429.6" "2861.8" "2263.2" "2375.7" "2860.0" "2828.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3143517004493314389" "False" "High" "IsMasterProtein" "Q01970" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 OS=Homo sapiens OX=9606 GN=PLCB3 PE=1 SV=2" "0.000" "False" "26.652" "8" "8" "9" "8" "1234" "138.7" "5.90" "22.46" "8" "other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00168, Pf00387, Pf00388, Pf08703, Pf09279, Pf17787" "5331" "ENSG00000149782" "PLCB3" "A5PKZ6; G5E960; hsa:5331; Q01970; Q8N1A4" "Alzheimer's disease and miRNA effects; S1P receptor signal transduction; Myometrial relaxation and contraction pathways; G protein signaling pathways; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; GPR40 pathway; MAPK cascade; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Hippo signaling regulation pathways; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; Calcium regulation in cardiac cells" "G alpha (q) signalling events; Synthesis of IP3 and IP4 in the cytosol; Ca2+ pathway; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; PLC beta mediated events; Acetylcholine regulates insulin secretion" "26" "0" "0.926" "0.995" "1.021" "0.969" "1.000" "0.984" "0.975" "0.987" "0.993" "542.5" "502.3" "539.8" "554.1" "525.6" "542.3" "534.1" "528.9" "535.3" "538.9" "" "" "" "" "" "" "" "" "" "" "508.3" "415.7" "501.1" "428.3" "448.0" "518.1" "488.0" "469.6" "535.3" "518.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2115401272640635068" "False" "High" "IsMasterProtein" "P41226" "Ubiquitin-like modifier-activating enzyme 7 OS=Homo sapiens OX=9606 GN=UBA7 PE=1 SV=2" "0.000" "False" "26.631" "9" "9" "10" "9" "1012" "111.6" "6.04" "31.58" "9" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00899, Pf09358, Pf10585, Pf16190, Pf16191" "7318" "ENSG00000182179" "UBA7" "hsa:7318; P41226; Q9BRB2" "Proteasome degradation; Parkinson's disease pathway" "Termination of translesion DNA synthesis; Antigen processing: Ubiquitination & Proteasome degradation; ISG15 antiviral mechanism; Negative regulators of DDX58/IFIH1 signaling" "7" "0" "1.025" "0.953" "1.041" "0.996" "0.974" "0.980" "0.942" "0.968" "1.023" "981.0" "1005.8" "934.8" "1021.3" "977.0" "955.2" "961.8" "923.8" "949.4" "1003.8" "" "" "" "" "" "" "" "" "" "" "919.2" "832.3" "867.9" "789.5" "832.7" "912.6" "878.8" "820.2" "949.4" "966.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5156803787758571728" "False" "High" "IsMasterProtein" "Q14444" "Caprin-1 OS=Homo sapiens OX=9606 GN=CAPRIN1 PE=1 SV=2" "0.000" "False" "26.605" "13" "10" "15" "10" "709" "78.3" "5.25" "47.18" "10" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf12287, Pf18293" "4076" "ENSG00000135387" "CAPRIN1" "A6NMY7; D3DR06; hsa:4076; Q14444; Q15074; Q6IMN4; Q6IMN7; Q9BV09" "" "" "0" "0" "1.020" "0.971" "0.962" "0.976" "1.042" "1.020" "1.033" "0.990" "0.958" "1838.0" "1874.9" "1784.0" "1768.6" "1793.5" "1914.6" "1874.6" "1897.9" "1819.2" "1761.3" "" "" "" "" "" "" "" "" "" "" "1722.2" "1551.4" "1656.2" "1367.2" "1528.7" "1829.2" "1712.9" "1685.2" "1819.2" "1695.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5749593247568362596" "False" "High" "IsMasterProtein" "Q9NYV4" "Cyclin-dependent kinase 12 OS=Homo sapiens OX=9606 GN=CDK12 PE=1 SV=2" "0.000" "False" "26.589" "6" "8" "10" "6" "1490" "164.1" "9.44" "33.53" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "51755" "ENSG00000167258" "CDK12" "A7E2B2; B4DYX4; B9EIQ6; hsa:51755; O94978; Q9NYV4" "17q12 copy number variation syndrome" "TP53 Regulates Transcription of DNA Repair Genes" "2" "0" "1.016" "0.983" "1.037" "1.067" "1.044" "1.125" "1.126" "1.100" "1.067" "490.3" "498.0" "481.9" "508.4" "522.9" "512.0" "551.3" "551.8" "539.2" "523.3" "" "" "" "" "" "" "" "" "" "" "459.4" "412.1" "447.4" "393.0" "445.7" "489.1" "503.7" "490.0" "539.2" "503.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4306142825200876867" "False" "High" "IsMasterProtein" "P11766" "Alcohol dehydrogenase class-3 OS=Homo sapiens OX=9606 GN=ADH5 PE=1 SV=4" "0.000" "False" "26.578" "26" "10" "15" "10" "374" "39.7" "7.49" "38.88" "10" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00107, Pf08240" "128" "ENSG00000197894" "ADH5" "hsa:128; P11766; Q6FHR2" "Folate-alcohol and cancer pathway hypotheses; Amino acid metabolism" "Ethanol oxidation" "3" "0" "0.955" "1.011" "0.953" "0.976" "1.032" "0.916" "1.006" "0.974" "1.008" "1286.3" "1228.2" "1300.1" "1225.7" "1255.2" "1327.1" "1178.7" "1294.2" "1253.1" "1296.5" "" "" "" "" "" "" "" "" "" "" "1205.3" "1016.3" "1207.0" "947.5" "1069.9" "1267.9" "1077.0" "1149.1" "1253.1" "1248.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1880293335037512275" "False" "High" "IsMasterProtein" "E9PAV3" "Nascent polypeptide-associated complex subunit alpha, muscle-specific form OS=Homo sapiens OX=9606 GN=NACA PE=1 SV=1" "0.000" "False" "26.570" "3" "5" "24" "5" "2078" "205.3" "9.58" "61.55" "5" "other biological processes" "translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01849, Pf19026" "" "ENSG00000196531" "NACA" "E9PAV3" "" "" "0" "0" "1.088" "1.044" "1.033" "1.077" "1.079" "1.011" "1.003" "0.968" "0.967" "1518.2" "1651.1" "1585.3" "1567.8" "1635.3" "1638.2" "1534.8" "1523.4" "1469.2" "1468.4" "" "" "" "" "" "" "" "" "" "" "1422.5" "1366.3" "1471.8" "1212.0" "1393.9" "1565.2" "1402.4" "1352.7" "1469.2" "1413.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1468233501590493710" "False" "High" "IsMasterProtein" "O60832" "H/ACA ribonucleoprotein complex subunit DKC1 OS=Homo sapiens OX=9606 GN=DKC1 PE=1 SV=3" "0.000" "False" "26.556" "18" "8" "11" "8" "514" "57.6" "9.42" "36.46" "8" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01472, Pf01509, Pf08068, Pf16198" "1736" "ENSG00000130826" "DKC1" "F5BSB3; hsa:1736; O43845; O60832; Q96G67; Q9Y505" "" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "2" "0" "0.962" "1.000" "0.963" "0.928" "0.990" "1.138" "1.201" "1.150" "1.026" "1919.1" "1845.2" "1918.4" "1847.4" "1781.0" "1899.8" "2184.2" "2304.6" "2207.3" "1969.4" "" "" "" "" "" "" "" "" "" "" "1798.2" "1526.9" "1781.0" "1428.2" "1518.1" "1815.1" "1995.7" "2046.3" "2207.3" "1896.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7462981975688921114" "False" "High" "IsMasterProtein" "Q7Z2T5" "TRMT1-like protein OS=Homo sapiens OX=9606 GN=TRMT1L PE=1 SV=2" "0.000" "False" "26.550" "11" "9" "10" "9" "733" "81.7" "7.88" "30.76" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02005" "81627" "ENSG00000121486" "TRMT1L" "hsa:81627; Q5TEN0; Q6ZMX0; Q7Z2T5; Q8IWH5; Q8NC68; Q9BZQ1" "" "" "0" "0" "1.096" "1.031" "1.094" "1.048" "0.943" "0.847" "0.914" "0.929" "0.975" "1279.7" "1403.1" "1318.8" "1400.7" "1341.7" "1206.4" "1084.2" "1169.2" "1188.9" "1247.2" "" "" "" "" "" "" "" "" "" "" "1199.1" "1161.1" "1224.4" "1082.8" "1143.6" "1152.6" "990.7" "1038.1" "1188.9" "1200.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1318153562653389017" "False" "High" "IsMasterProtein" "O43837" "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3B PE=1 SV=2" "0.000" "False" "26.548" "24" "9" "11" "9" "385" "42.2" "8.46" "35.70" "9" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00180" "3420" "ENSG00000101365" "IDH3B" "B2RDR1; D3DVX2; D3DVX3; hsa:3420; O43837; O95106; Q5JXS8; Q9NQ06; Q9NQ07; Q9NUZ0; Q9UEX0; Q9UG99" "TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle)" "2" "0" "0.990" "1.015" "0.956" "0.993" "0.997" "0.911" "0.964" "0.959" "0.964" "1224.6" "1211.9" "1243.4" "1171.1" "1216.0" "1220.7" "1115.6" "1180.1" "1174.4" "1180.2" "" "" "" "" "" "" "" "" "" "" "1147.5" "1002.9" "1154.3" "905.3" "1036.4" "1166.3" "1019.3" "1047.8" "1174.4" "1136.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6716133539155154712" "False" "High" "IsMasterProtein" "P82650" "Small ribosomal subunit protein mS22 OS=Homo sapiens OX=9606 GN=MRPS22 PE=1 SV=1" "0.000" "False" "26.492" "22" "9" "9" "9" "360" "41.3" "7.90" "26.08" "9" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10245" "56945" "ENSG00000175110" "MRPS22" "hsa:56945; P82650; Q9H3I1" "Primary ovarian insufficiency" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "1.046" "1.081" "1.046" "1.019" "1.026" "0.973" "0.952" "0.933" "0.996" "1346.8" "1408.4" "1455.6" "1408.5" "1372.6" "1381.5" "1310.0" "1282.4" "1256.0" "1341.3" "" "" "" "" "" "" "" "" "" "" "1262.0" "1165.4" "1351.4" "1088.8" "1170.0" "1319.8" "1197.0" "1138.7" "1256.0" "1291.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3138004166962983246" "False" "High" "IsMasterProtein" "Q92688" "Acidic leucine-rich nuclear phosphoprotein 32 family member B OS=Homo sapiens OX=9606 GN=ANP32B PE=1 SV=1" "0.000" "False" "26.483" "31" "7" "11" "4" "251" "28.8" "4.06" "38.44" "7" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12799" "10541" "ENSG00000136938" "ANP32B" "B2R9C7; hsa:10541; O00655; P78458; P78459; Q92688" "" "" "0" "0" "0.913" "0.890" "0.882" "0.868" "0.855" "0.986" "1.046" "0.987" "0.868" "1287.6" "1175.5" "1145.3" "1135.2" "1117.1" "1100.9" "1270.1" "1346.9" "1270.4" "1117.7" "" "" "" "" "" "" "" "" "" "" "1206.5" "972.7" "1063.3" "877.5" "952.2" "1051.8" "1160.5" "1195.9" "1270.4" "1076.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "879339039440763847" "False" "High" "IsMasterProtein" "A6NI72" "Putative neutrophil cytosol factor 1B OS=Homo sapiens OX=9606 GN=NCF1B PE=5 SV=2" "0.000" "False" "26.463" "23" "9" "14" "9" "391" "44.8" "9.13" "42.47" "9" "other metabolic processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00787, Pf08944, Pf16621" "" "" "NCF1B" "A6NI72" "" "" "0" "0" "0.916" "0.956" "0.942" "0.932" "0.943" "0.957" "0.972" "0.946" "0.940" "1713.0" "1569.9" "1637.3" "1614.2" "1597.2" "1614.6" "1640.0" "1665.5" "1620.7" "1610.5" "" "" "" "" "" "" "" "" "" "" "1605.1" "1299.1" "1520.0" "1247.8" "1361.4" "1542.6" "1498.5" "1478.8" "1620.7" "1550.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4406338825216404645" "False" "High" "IsMasterProtein" "Q16740" "ATP-dependent Clp protease proteolytic subunit, mitochondrial OS=Homo sapiens OX=9606 GN=CLPP PE=1 SV=1" "0.000" "False" "26.452" "42" "9" "11" "9" "277" "30.2" "8.09" "35.38" "9" "protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00574" "8192" "ENSG00000125656" "CLPP" "B2R4W5; hsa:8192; Q16740" "Primary ovarian insufficiency" "Mitochondrial protein degradation" "2" "0" "1.337" "1.079" "1.019" "1.108" "1.114" "1.075" "1.057" "1.053" "1.050" "931.4" "1245.0" "1005.4" "949.5" "1032.3" "1038.0" "1001.0" "984.7" "980.6" "978.2" "" "" "" "" "" "" "" "" "" "" "872.8" "1030.2" "933.4" "734.0" "879.9" "991.7" "914.7" "874.3" "980.6" "941.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4607274144029287900" "False" "High" "IsMasterProtein" "O14929" "Histone acetyltransferase type B catalytic subunit OS=Homo sapiens OX=9606 GN=HAT1 PE=1 SV=2" "0.000" "False" "26.418" "18" "6" "10" "6" "419" "49.5" "5.69" "30.73" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf10394, Pf21183" "8520" "ENSG00000128708" "HAT1" "hsa:8520; O14929; Q49A44; Q53QF0; Q53SU4; Q6P594; Q8WWB9" "Ethanol effects on histone modifications" "HATs acetylate histones" "2" "0" "1.081" "1.057" "1.123" "1.109" "1.020" "1.109" "1.005" "1.054" "1.103" "519.5" "561.3" "548.9" "583.6" "575.8" "529.9" "576.0" "521.9" "547.5" "573.0" "" "" "" "" "" "" "" "" "" "" "486.7" "464.5" "509.6" "451.1" "490.8" "506.2" "526.3" "463.4" "547.5" "551.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3080105971862608535" "False" "High" "IsMasterProtein" "Q9BYJ9" "YTH domain-containing family protein 1 OS=Homo sapiens OX=9606 GN=YTHDF1 PE=1 SV=1" "0.000" "False" "26.412" "14" "8" "11" "4" "559" "60.8" "8.79" "34.95" "8" "cell organization and biogenesis;other biological processes" "other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04146" "54915" "ENSG00000149658" "YTHDF1" "hsa:54915; Q8N3G5; Q8TBT1; Q96AN4; Q96S57; Q9BTI7; Q9BYJ9; Q9NX79" "" "" "0" "0" "1.013" "1.067" "1.073" "1.032" "1.063" "1.017" "1.041" "1.058" "1.063" "547.9" "555.3" "584.4" "587.7" "565.3" "582.4" "556.9" "570.4" "579.5" "582.3" "" "" "" "" "" "" "" "" "" "" "513.3" "459.5" "542.5" "454.3" "481.8" "556.4" "508.9" "506.5" "579.5" "560.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2243304084648640018" "False" "High" "IsMasterProtein" "P49585" "Choline-phosphate cytidylyltransferase A OS=Homo sapiens OX=9606 GN=PCYT1A PE=1 SV=2" "0.000" "False" "26.388" "32" "11" "13" "11" "367" "41.7" "7.25" "32.65" "11" "other metabolic processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01467" "5130" "ENSG00000161217" "PCYT1A" "A9LYK9; D3DXB1; hsa:5130; P49585; Q86Y88" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids; 3q29 copy number variation syndrome; Acetylcholine synthesis" "Synthesis of PC" "7" "0" "1.011" "0.981" "1.016" "1.022" "1.066" "0.976" "1.005" "0.985" "1.026" "1409.9" "1424.9" "1383.7" "1432.6" "1441.4" "1502.5" "1376.0" "1417.6" "1388.8" "1446.8" "" "" "" "" "" "" "" "" "" "" "1321.1" "1179.1" "1284.6" "1107.5" "1228.6" "1435.5" "1257.3" "1258.7" "1388.8" "1393.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8447148284608472051" "False" "High" "IsMasterProtein" "Q9H444" "Charged multivesicular body protein 4b OS=Homo sapiens OX=9606 GN=CHMP4B PE=1 SV=1" "0.000" "False" "26.388" "37" "9" "13" "9" "224" "24.9" "4.82" "37.11" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "128866" "ENSG00000101421" "CHMP4B" "E1P5N4; hsa:128866; Q53ZD6; Q9H444" "" "Sealing of the nuclear envelope (NE) by ESCRT-III; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "9" "0" "1.004" "0.988" "1.063" "0.997" "1.023" "0.997" "1.032" "1.156" "1.111" "1897.2" "1904.8" "1873.7" "2017.3" "1891.1" "1940.9" "1892.5" "1958.4" "2194.1" "2108.7" "" "" "" "" "" "" "" "" "" "" "1777.7" "1576.2" "1739.5" "1559.5" "1611.9" "1854.4" "1729.2" "1738.8" "2194.1" "2030.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570551838394526128" "False" "High" "IsMasterProtein" "Q86VN1" "Vacuolar protein-sorting-associated protein 36 OS=Homo sapiens OX=9606 GN=VPS36 PE=1 SV=1" "0.000" "False" "26.374" "21" "8" "10" "8" "386" "43.8" "7.20" "30.02" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf04157, Pf11605" "51028" "ENSG00000136100" "VPS36" "A8K125; hsa:51028; Q3ZCV7; Q5H9S1; Q5VXB6; Q86VN1; Q9H8Z5; Q9Y3E3" "Network map of SARS-CoV-2 signaling pathway" "Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events" "3" "0" "1.033" "0.973" "1.034" "1.053" "0.992" "1.006" "0.993" "0.922" "0.971" "1112.7" "1148.9" "1083.2" "1150.5" "1172.0" "1103.7" "1119.0" "1105.2" "1026.0" "1080.5" "" "" "" "" "" "" "" "" "" "" "1042.6" "950.7" "1005.6" "889.4" "998.9" "1054.5" "1022.5" "981.3" "1026.0" "1040.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7652533075202528091" "False" "High" "IsMasterProtein" "Q92734" "Protein TFG OS=Homo sapiens OX=9606 GN=TFG PE=1 SV=2" "0.000" "False" "26.365" "30" "9" "10" "9" "400" "43.4" "5.10" "34.98" "9" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00564" "10342" "ENSG00000114354" "TFG" "D3DN49; G5E9V1; hsa:10342; K0J5S8; K0J6K2; Q15656; Q92734; Q969I2" "" "COPII-mediated vesicle transport; Signaling by ALK fusions and activated point mutants" "2" "0" "1.159" "1.005" "1.116" "0.914" "0.851" "0.755" "1.017" "0.939" "0.999" "596.6" "691.4" "599.7" "665.9" "545.3" "507.4" "450.5" "606.6" "560.3" "595.7" "" "" "" "" "" "" "" "" "" "" "559.0" "572.1" "556.7" "514.8" "464.8" "484.8" "411.6" "538.6" "560.3" "573.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-792306396308701389" "False" "High" "IsMasterProtein" "Q9Y2W1" "Thyroid hormone receptor-associated protein 3 OS=Homo sapiens OX=9606 GN=THRAP3 PE=1 SV=2" "0.000" "False" "26.357" "9" "9" "10" "8" "955" "108.6" "10.15" "26.36" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf15440" "9967" "ENSG00000054118" "THRAP3" "D3DPS5; hsa:9967; Q5VTK6; Q9Y2W1" "Interactome of polycomb repressive complex 2 (PRC2)" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation" "3" "1" "1.060" "0.966" "1.037" "1.096" "1.081" "1.268" "1.274" "1.258" "1.109" "1214.4" "1287.5" "1173.5" "1259.4" "1331.4" "1312.8" "1540.0" "1547.2" "1527.6" "1347.3" "" "" "" "" "" "" "" "" "" "" "1137.9" "1065.4" "1089.4" "973.6" "1134.8" "1254.3" "1407.1" "1373.7" "1527.6" "1297.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1583521273813264514" "False" "High" "IsMasterProtein" "P35236" "Tyrosine-protein phosphatase non-receptor type 7 OS=Homo sapiens OX=9606 GN=PTPN7 PE=1 SV=3" "0.000" "False" "26.356" "28" "9" "10" "9" "360" "40.5" "6.79" "34.05" "9" "protein metabolism;other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00102" "5778" "ENSG00000143851" "PTPN7" "B3KXE1; hsa:5778; P35236; Q53XK4; Q5SXQ0; Q5SXQ1; Q9BV05" "MAPK signaling pathway; IL-18 signaling pathway" "Interleukin-37 signaling; Negative regulation of MAPK pathway" "4" "0" "0.968" "0.963" "0.906" "0.987" "0.973" "0.944" "0.905" "0.998" "0.969" "1289.0" "1247.6" "1240.7" "1168.4" "1272.7" "1254.8" "1216.2" "1167.2" "1286.1" "1249.6" "" "" "" "" "" "" "" "" "" "" "1207.8" "1032.4" "1151.8" "903.2" "1084.8" "1198.9" "1111.3" "1036.3" "1286.1" "1203.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3092682979585279254" "False" "High" "IsMasterProtein" "Q96BP3" "Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=PPWD1 PE=1 SV=1" "0.000" "False" "26.356" "16" "10" "10" "10" "646" "73.5" "7.15" "31.62" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00160, Pf00400" "23398" "ENSG00000113593" "PPWD1" "B4DWR9; hsa:23398; Q15002; Q7KZ89; Q96BP3" "" "mRNA Splicing - Major Pathway" "1" "0" "1.051" "1.037" "1.087" "1.081" "1.030" "1.075" "1.093" "1.090" "1.077" "439.5" "461.8" "455.9" "477.9" "475.0" "452.5" "472.4" "480.2" "478.9" "473.4" "" "" "" "" "" "" "" "" "" "" "411.8" "382.1" "423.3" "369.5" "404.9" "432.3" "431.6" "426.4" "478.9" "455.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9179155935409940173" "False" "High" "IsMasterProtein" "Q15750" "TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 OS=Homo sapiens OX=9606 GN=TAB1 PE=1 SV=1" "0.000" "False" "26.326" "18" "9" "11" "9" "504" "54.6" "5.52" "31.86" "9" "developmental processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00481" "10454" "ENSG00000100324" "TAB1" "hsa:10454; Q15750; Q2PP09; Q8IZW2" "MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; TGF-beta signaling pathway; MAPK signaling pathway; TLR4 signaling and tolerance; miRNA role in immune response in sepsis; Signal transduction through IL1R; Hepatitis B infection; Toll-like receptor signaling pathway" "NOD1/2 Signaling Pathway; Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; FCERI mediated NF-kB activation; CLEC7A (Dectin-1) signaling; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; TAK1-dependent IKK and NF-kappa-B activation ; TNFR1-induced NF-kappa-B signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway" "27" "0" "1.263" "1.087" "1.401" "1.338" "0.956" "1.185" "1.004" "1.053" "1.040" "52.1" "65.8" "56.7" "73.0" "69.7" "49.8" "61.8" "52.3" "54.9" "54.2" "" "" "" "" "" "" "" "" "" "" "48.8" "54.5" "52.6" "56.4" "59.4" "47.6" "56.4" "46.5" "54.9" "52.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4929708673540461466" "False" "High" "IsMasterProtein" "Q9UHP3" "Ubiquitin carboxyl-terminal hydrolase 25 OS=Homo sapiens OX=9606 GN=USP25 PE=1 SV=4" "0.000" "False" "26.324" "9" "9" "9" "9" "1055" "122.1" "5.34" "25.42" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf00443, Pf02809" "29761" "ENSG00000155313" "USP25" "C0LSZ0; hsa:29761; Q6DHZ9; Q9H9W1; Q9UHP3" "" "Ub-specific processing proteases" "1" "0" "0.963" "0.963" "1.036" "1.007" "1.011" "0.961" "0.957" "0.958" "1.031" "971.8" "936.3" "936.2" "1007.0" "978.1" "982.7" "934.2" "930.4" "931.3" "1001.9" "" "" "" "" "" "" "" "" "" "" "910.6" "774.8" "869.1" "778.5" "833.7" "938.9" "853.6" "826.1" "931.3" "964.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1188306556528865133" "False" "High" "IsMasterProtein" "Q15691" "Microtubule-associated protein RP/EB family member 1 OS=Homo sapiens OX=9606 GN=MAPRE1 PE=1 SV=3" "0.000" "False" "26.307" "32" "8" "20" "8" "268" "30.0" "5.14" "64.94" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf03271" "22919" "ENSG00000101367" "MAPRE1" "B2R6I7; E1P5M8; hsa:22919; Q15691; Q3KQS8" "Microtubule cytoskeleton regulation; HDAC6 interactions in the central nervous system" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "16" "0" "0.951" "0.965" "0.974" "0.974" "0.990" "0.970" "0.989" "0.966" "0.938" "2450.5" "2330.4" "2365.7" "2386.2" "2387.0" "2426.1" "2377.5" "2423.9" "2367.8" "2299.7" "" "" "" "" "" "" "" "" "" "" "2296.1" "1928.4" "2196.3" "1844.6" "2034.6" "2317.9" "2172.4" "2152.1" "2367.8" "2214.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9153241618277291639" "False" "High" "IsMasterProtein" "Q9ULK4" "Mediator of RNA polymerase II transcription subunit 23 OS=Homo sapiens OX=9606 GN=MED23 PE=1 SV=2" "0.000" "False" "26.294" "7" "9" "9" "9" "1368" "156.4" "7.40" "29.56" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11573" "9439" "ENSG00000112282" "MED23" "B9TX55; hsa:9439; O95403; Q5JWT3; Q5JWT4; Q6P9H6; Q9H0J2; Q9NTT9; Q9NTU0; Q9ULK4; Q9Y5P7; Q9Y667" "" "PPARA activates gene expression; RSV-host interactions; Generic Transcription Pathway; Transcriptional regulation of white adipocyte differentiation" "4" "0" "1.161" "0.957" "1.191" "0.890" "0.895" "0.866" "0.875" "0.916" "0.841" "727.7" "844.8" "696.5" "866.7" "647.6" "651.1" "629.9" "636.4" "666.6" "612.2" "" "" "" "" "" "" "" "" "" "" "681.8" "699.1" "646.6" "670.0" "552.0" "622.0" "575.5" "565.1" "666.6" "589.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4686891910023409545" "False" "High" "IsMasterProtein" "P62140" "Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CB PE=1 SV=3" "0.000" "False" "26.283" "28" "8" "11" "2" "327" "37.2" "6.19" "30.55" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5500" "ENSG00000213639" "PPP1CB" "B2R5V4; D6W565; hsa:5500; P37140; P62140; Q5U087; Q6FG45" "Common pathways underlying drug addiction; Focal adhesion; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Airway smooth muscle cell contraction; Neuroinflammation and glutamatergic signaling; G13 signaling pathway" "RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; Triglyceride catabolism; Regulation of PLK1 Activity at G2/M Transition; Circadian Clock; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; RHO GTPases activate PAKs; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins" "19" "0" "0.967" "0.986" "1.049" "0.954" "1.080" "1.065" "1.072" "1.081" "1.018" "486.7" "470.8" "480.1" "510.7" "464.4" "525.7" "518.4" "521.5" "526.3" "495.3" "" "" "" "" "" "" "" "" "" "" "456.1" "389.6" "445.7" "394.8" "395.9" "502.3" "473.7" "463.1" "526.3" "476.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6901270763620924094" "False" "High" "IsMasterProtein" "Q6P1N9" "Deoxyribonuclease TATDN1 OS=Homo sapiens OX=9606 GN=TATDN1 PE=1 SV=2" "0.000" "False" "26.260" "24" "7" "11" "7" "297" "33.6" "6.96" "35.59" "7" "DNA metabolism" "nucleus" "other molecular function" "Pf01026" "83940" "ENSG00000147687; ENSG00000291730" "TATDN1" "B2R5J0; hsa:83940; Q6P1N9; Q8TD02; Q9BY40" "" "" "0" "0" "0.927" "0.919" "0.910" "0.886" "0.913" "0.852" "0.943" "0.906" "0.900" "1734.6" "1607.6" "1593.5" "1578.9" "1537.1" "1584.4" "1477.7" "1636.0" "1571.4" "1561.1" "" "" "" "" "" "" "" "" "" "" "1625.3" "1330.3" "1479.4" "1220.6" "1310.2" "1513.7" "1350.3" "1452.6" "1571.4" "1503.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "513185524036398277" "False" "High" "IsMasterProtein" "Q9NUQ3" "Gamma-taxilin OS=Homo sapiens OX=9606 GN=TXLNG PE=1 SV=2" "0.000" "False" "26.242" "16" "8" "11" "8" "528" "60.5" "7.52" "33.07" "8" "cell cycle OR cell proliferation;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf09728" "55787" "ENSG00000086712" "TXLNG" "hsa:55787; Q2KQ75; Q5JNZ7; Q9NUQ3; Q9P0X1" "" "" "0" "0" "1.030" "0.972" "0.958" "0.925" "0.956" "0.949" "0.961" "0.931" "0.969" "1926.2" "1983.2" "1871.5" "1844.4" "1781.8" "1842.3" "1827.1" "1850.2" "1792.5" "1865.8" "" "" "" "" "" "" "" "" "" "" "1804.9" "1641.1" "1737.5" "1425.8" "1518.8" "1760.1" "1669.5" "1642.8" "1792.5" "1796.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7747633478491734615" "False" "High" "IsMasterProtein" "Q96BW5" "Phosphotriesterase-related protein OS=Homo sapiens OX=9606 GN=PTER PE=1 SV=1" "0.000" "False" "26.233" "27" "10" "15" "10" "349" "39.0" "6.52" "43.53" "10" "other metabolic processes;other biological processes" "" "other molecular function" "Pf02126" "9317" "ENSG00000165983" "PTER" "B0YJ77; B3KTF5; D3DRU0; hsa:9317; Q96BW5; Q9BY46" "" "" "0" "0" "0.934" "0.953" "1.024" "0.951" "0.990" "0.966" "0.969" "0.990" "0.984" "831.9" "776.7" "792.8" "851.5" "791.3" "823.9" "803.7" "805.8" "823.6" "818.4" "" "" "" "" "" "" "" "" "" "" "779.5" "642.7" "736.0" "658.3" "674.5" "787.2" "734.4" "715.5" "823.6" "788.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5797798922783167285" "False" "High" "IsMasterProtein" "Q2TAY7" "WD40 repeat-containing protein SMU1 OS=Homo sapiens OX=9606 GN=SMU1 PE=1 SV=2" "0.000" "False" "26.197" "18" "9" "11" "9" "513" "57.5" "7.18" "32.75" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf17814" "55234" "ENSG00000122692" "SMU1" "B4E3L0; hsa:55234; Q2TAY7; Q9BU59; Q9HA96; Q9NVD1" "" "mRNA Splicing - Major Pathway" "1" "0" "0.988" "1.030" "1.120" "1.175" "1.157" "1.293" "1.459" "1.404" "1.187" "704.3" "696.1" "725.4" "789.0" "827.8" "815.2" "911.0" "1027.9" "988.6" "836.0" "" "" "" "" "" "" "" "" "" "" "659.9" "576.1" "673.4" "609.9" "705.6" "778.8" "832.4" "912.7" "988.6" "805.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-917272071926626278" "False" "High" "IsMasterProtein" "Q99797" "Mitochondrial intermediate peptidase OS=Homo sapiens OX=9606 GN=MIPEP PE=1 SV=2" "0.000" "False" "26.193" "12" "10" "17" "9" "713" "80.6" "7.05" "37.87" "10" "protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf01432" "4285" "ENSG00000027001" "MIPEP" "hsa:4285; Q5JV15; Q5T9Q9; Q96G65; Q99797" "13q12.12 copy number variation" "" "1" "0" "1.096" "1.077" "1.096" "1.115" "1.056" "1.057" "1.001" "1.088" "1.064" "518.4" "568.3" "558.6" "568.1" "578.3" "547.4" "547.8" "519.0" "564.0" "551.7" "" "" "" "" "" "" "" "" "" "" "485.8" "470.2" "518.6" "439.1" "492.9" "523.0" "500.5" "460.8" "564.0" "531.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3946682035619075212" "False" "High" "IsMasterProtein" "Q00688" "Peptidyl-prolyl cis-trans isomerase FKBP3 OS=Homo sapiens OX=9606 GN=FKBP3 PE=1 SV=1" "0.000" "False" "26.171" "33" "7" "13" "7" "224" "25.2" "9.28" "44.96" "7" "" "nucleus" "other molecular function" "Pf00254, Pf18410" "2287" "ENSG00000100442" "FKBP3" "B2R4Q9; hsa:2287; Q00688; Q14317" "" "" "0" "0" "1.053" "0.997" "0.928" "1.029" "1.147" "1.033" "0.993" "0.997" "1.041" "978.7" "1030.3" "975.7" "908.1" "1007.1" "1123.0" "1011.0" "971.9" "975.9" "1019.2" "" "" "" "" "" "" "" "" "" "" "917.1" "852.6" "905.8" "702.0" "858.4" "1072.9" "923.8" "862.9" "975.9" "981.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7971569862806086425" "False" "High" "IsMasterProtein" "Q9Y2Z4" "Tyrosine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=YARS2 PE=1 SV=2" "0.000" "False" "26.160" "24" "11" "14" "11" "477" "53.2" "8.98" "40.36" "11" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00579" "51067" "ENSG00000139131" "YARS2" "D3DUW8; hsa:51067; Q9H817; Q9Y2Z4" "Orexin receptor pathway" "Mitochondrial tRNA aminoacylation" "2" "0" "0.993" "1.030" "1.033" "1.035" "1.040" "1.032" "1.034" "1.017" "1.047" "1776.9" "1765.2" "1830.7" "1836.3" "1839.9" "1847.9" "1833.3" "1837.9" "1806.3" "1860.2" "" "" "" "" "" "" "" "" "" "" "1665.0" "1460.6" "1699.6" "1419.5" "1568.3" "1765.5" "1675.2" "1631.9" "1806.3" "1791.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7237194878275625611" "False" "High" "IsMasterProtein" "Q9Y224" "RNA transcription, translation and transport factor protein OS=Homo sapiens OX=9606 GN=RTRAF PE=1 SV=1" "0.000" "False" "26.145" "37" "10" "14" "10" "244" "28.1" "6.65" "44.17" "10" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10036" "51637" "ENSG00000087302" "RTRAF" "hsa:51637; Q9Y224" "" "tRNA processing in the nucleus" "1" "0" "1.031" "0.978" "1.013" "0.952" "1.043" "0.894" "1.008" "0.999" "0.974" "2496.3" "2574.5" "2442.4" "2528.9" "2375.5" "2604.1" "2231.0" "2517.3" "2493.5" "2432.6" "" "" "" "" "" "" "" "" "" "" "2339.1" "2130.3" "2267.4" "1955.0" "2024.8" "2488.0" "2038.6" "2235.1" "2493.5" "2342.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2494116660910275017" "False" "High" "IsMasterProtein" "Q9H814" "Phosphorylated adapter RNA export protein OS=Homo sapiens OX=9606 GN=PHAX PE=1 SV=1" "0.000" "False" "26.124" "20" "7" "9" "7" "394" "44.4" "5.40" "31.31" "7" "transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10258" "51808" "ENSG00000164902" "PHAX" "hsa:51808; Q9H814; Q9H8W1" "" "RNA polymerase II transcribes snRNA genes; snRNP Assembly" "2" "0" "1.022" "0.986" "1.039" "1.035" "1.040" "1.018" "1.048" "1.065" "1.015" "764.2" "781.0" "753.4" "794.1" "791.2" "794.9" "777.7" "801.0" "814.2" "775.7" "" "" "" "" "" "" "" "" "" "" "716.0" "646.3" "699.4" "613.8" "674.4" "759.4" "710.6" "711.2" "814.2" "746.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3690320084066520669" "False" "High" "IsMasterProtein" "Cont_P04259" "Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5" "0.000" "True" "26.117" "11" "10" "17" "0" "564" "60.0" "8.00" "48.56" "10" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3854" "ENSG00000185479" "KRT6B" "hsa:3854; P04259; P48669" "" "Formation of the cornified envelope" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "-327475496585371320" "False" "High" "IsMasterProtein" "Q9BWD1" "Acetyl-CoA acetyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=ACAT2 PE=1 SV=2" "0.000" "False" "26.107" "19" "8" "18" "8" "397" "41.3" "6.92" "56.40" "8" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00108, Pf02803" "39" "ENSG00000120437" "ACAT2" "B7Z233; E1P5B1; hsa:39; Q16146; Q5TCL7; Q8TDM4; Q9BWD1" "Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "Cholesterol biosynthesis" "6" "0" "0.958" "0.929" "0.987" "0.896" "1.001" "0.950" "0.928" "0.920" "0.940" "1408.9" "1349.2" "1309.5" "1390.0" "1262.5" "1411.0" "1338.1" "1307.7" "1296.0" "1323.8" "" "" "" "" "" "" "" "" "" "" "1320.1" "1116.5" "1215.7" "1074.5" "1076.1" "1348.1" "1222.7" "1161.1" "1296.0" "1274.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7521593605618506386" "False" "High" "IsMasterProtein" "Q02556" "Interferon regulatory factor 8 OS=Homo sapiens OX=9606 GN=IRF8 PE=1 SV=2" "0.000" "False" "26.091" "23" "10" "13" "10" "426" "48.3" "6.77" "40.12" "10" "other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3394" "ENSG00000140968" "IRF8" "A0AV82; hsa:3394; Q02556" "Vitamin D receptor pathway; Development of pulmonary dendritic cells and macrophage subsets; Extrafollicular and follicular B cell activation by SARS-CoV-2; 2q37 copy number variation syndrome; Type II interferon signaling" "Interferon gamma signaling; Interferon alpha/beta signaling" "7" "0" "1.017" "1.001" "1.025" "0.988" "0.934" "0.926" "0.903" "0.901" "0.958" "1068.4" "1087.1" "1069.4" "1095.2" "1055.9" "998.0" "989.3" "965.2" "963.1" "1023.3" "" "" "" "" "" "" "" "" "" "" "1001.1" "899.5" "992.8" "846.6" "900.0" "953.5" "904.0" "857.0" "963.1" "985.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8993945663539599820" "False" "High" "IsMasterProtein" "P61026" "Ras-related protein Rab-10 OS=Homo sapiens OX=9606 GN=RAB10 PE=1 SV=1" "0.000" "False" "26.082" "40" "9" "14" "7" "200" "22.5" "8.38" "44.77" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "10890" "ENSG00000084733" "RAB10" "D6W538; hsa:10890; O88386; P61026; Q6IA52; Q9D7X6; Q9H0T3" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation; RAB geranylgeranylation" "5" "0" "1.031" "0.973" "1.034" "0.964" "0.992" "0.968" "1.013" "1.026" "0.962" "1313.3" "1354.0" "1278.5" "1358.1" "1266.5" "1302.3" "1271.8" "1330.0" "1347.9" "1263.0" "" "" "" "" "" "" "" "" "" "" "1230.6" "1120.5" "1186.9" "1049.9" "1079.6" "1244.2" "1162.1" "1180.9" "1347.9" "1216.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6225223608593832705" "False" "High" "IsMasterProtein" "Q99856" "AT-rich interactive domain-containing protein 3A OS=Homo sapiens OX=9606 GN=ARID3A PE=1 SV=2" "0.000" "False" "26.065" "15" "8" "8" "8" "593" "62.9" "4.91" "25.54" "8" "other biological processes" "other membranes;cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01388" "1820" "ENSG00000116017" "ARID3A" "hsa:1820; Q5I858; Q6P9C6; Q8IZA7; Q8N4Z3; Q99856" "HDAC6 interactions in the central nervous system" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest" "2" "0" "0.975" "0.988" "0.976" "1.014" "0.984" "1.002" "0.928" "0.943" "1.003" "866.0" "844.0" "855.2" "845.0" "878.1" "852.2" "867.4" "804.0" "816.6" "869.0" "" "" "" "" "" "" "" "" "" "" "811.4" "698.4" "793.9" "653.2" "748.4" "814.2" "792.6" "713.8" "816.6" "836.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1575369473679167499" "False" "High" "IsMasterProtein" "Q00059" "Transcription factor A, mitochondrial OS=Homo sapiens OX=9606 GN=TFAM PE=1 SV=1" "0.000" "False" "26.059" "39" "12" "15" "12" "246" "29.1" "9.72" "43.91" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "7019" "ENSG00000108064" "TFAM" "A8MRB2; A9QXC6; B5BU05; hsa:7019; Q00059; Q5U0C6" "Energy metabolism; NAD metabolism, sirtuins and aging; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Orexin receptor pathway; Sildenafil treatment" "Mitochondrial protein degradation; Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis" "9" "0" "1.177" "1.158" "1.135" "1.067" "1.043" "1.008" "1.079" "1.089" "1.073" "3455.4" "4067.3" "4002.0" "3922.8" "3688.5" "3605.5" "3483.1" "3729.1" "3764.3" "3706.8" "" "" "" "" "" "" "" "" "" "" "3237.7" "3365.6" "3715.3" "3032.5" "3144.0" "3444.7" "3182.6" "3311.0" "3764.3" "3569.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1361543221458196950" "False" "High" "IsMasterProtein" "O60547" "GDP-mannose 4,6 dehydratase OS=Homo sapiens OX=9606 GN=GMDS PE=1 SV=1" "0.000" "False" "26.049" "25" "10" "11" "10" "372" "41.9" "7.31" "35.27" "10" "other metabolic processes;signal transduction" "cytosol;other cell component" "other molecular function" "Pf16363" "2762" "ENSG00000112699" "GMDS" "E9PI88; hsa:2762; O60547; O75357; Q5T954; Q6FH09; Q9UGZ3; Q9UJK9" "" "GDP-fucose biosynthesis" "1" "0" "0.821" "1.096" "0.857" "0.916" "0.822" "0.798" "0.813" "0.782" "0.819" "1798.8" "1476.4" "1972.0" "1542.0" "1647.5" "1478.5" "1434.8" "1462.7" "1406.1" "1472.6" "" "" "" "" "" "" "" "" "" "" "1685.5" "1221.7" "1830.8" "1192.1" "1404.3" "1412.6" "1311.0" "1298.7" "1406.1" "1418.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5077624206486076316" "False" "High" "IsMasterProtein" "Q8TC07" "TBC1 domain family member 15 OS=Homo sapiens OX=9606 GN=TBC1D15 PE=1 SV=2" "0.000" "False" "26.041" "13" "9" "9" "9" "691" "79.4" "5.67" "30.82" "9" "other biological processes" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00566, Pf12068" "64786" "ENSG00000121749" "TBC1D15" "B4DMT9; B9A6L6; hsa:64786; J3KNI9; Q8TC07; Q9HA83" "" "TBC/RABGAPs" "1" "0" "0.963" "0.944" "0.944" "1.015" "1.112" "1.069" "0.926" "1.123" "1.039" "1761.8" "1695.7" "1663.7" "1663.0" "1788.0" "1959.9" "1884.2" "1631.7" "1978.9" "1829.6" "" "" "" "" "" "" "" "" "" "" "1650.8" "1403.2" "1544.5" "1285.6" "1524.0" "1872.5" "1721.7" "1448.8" "1978.9" "1761.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2034922387344060046" "False" "High" "IsMasterProtein" "P12955" "Xaa-Pro dipeptidase OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=3" "0.000" "False" "26.014" "18" "8" "8" "8" "493" "54.5" "6.00" "31.12" "8" "protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf00557, Pf05195" "5184" "ENSG00000124299" "PEPD" "A8K3Z1; A8K416; A8K696; A8MX47; B4DDB7; B4DGJ1; E9PCE8; hsa:5184; P12955; Q8TBN9; Q9BT75" "" "" "0" "0" "0.968" "0.866" "1.077" "0.905" "1.078" "0.888" "0.952" "0.886" "0.930" "1765.9" "1710.1" "1529.9" "1901.0" "1598.3" "1904.4" "1567.6" "1681.4" "1564.6" "1642.7" "" "" "" "" "" "" "" "" "" "" "1654.6" "1415.0" "1420.3" "1469.6" "1362.4" "1819.4" "1432.4" "1492.9" "1564.6" "1581.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-154520297388586765" "False" "High" "IsMasterProtein" "Q9HCC0" "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Homo sapiens OX=9606 GN=MCCC2 PE=1 SV=1" "0.000" "False" "26.005" "18" "9" "11" "9" "563" "61.3" "7.68" "35.44" "9" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01039" "64087" "ENSG00000131844" "MCCC2" "A6NIY9; hsa:64087; Q96C27; Q9HCC0; Q9Y4L7" "" "Biotin transport and metabolism; Branched-chain amino acid catabolism; Defective HLCS causes multiple carboxylase deficiency" "3" "0" "1.079" "1.055" "0.978" "1.048" "1.154" "0.955" "1.060" "1.100" "1.067" "1067.9" "1152.4" "1126.8" "1044.4" "1118.7" "1232.2" "1020.3" "1132.4" "1174.4" "1139.3" "" "" "" "" "" "" "" "" "" "" "1000.6" "953.6" "1046.1" "807.4" "953.5" "1177.2" "932.3" "1005.5" "1174.4" "1097.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3739343134974919134" "False" "High" "IsMasterProtein" "Q92804" "TATA-binding protein-associated factor 2N OS=Homo sapiens OX=9606 GN=TAF15 PE=1 SV=1" "0.000" "False" "25.943" "21" "7" "15" "5" "592" "61.8" "8.02" "49.99" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "8148" "ENSG00000270647; ENSG00000276833" "TAF15" "B2R837; hsa:8148; Q86X94; Q92751; Q92804" "17q12 copy number variation syndrome" "Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "10" "0" "1.009" "1.046" "1.147" "1.165" "1.299" "2.027" "2.082" "1.932" "1.409" "472.8" "477.0" "494.5" "542.1" "551.0" "614.3" "958.3" "984.2" "913.3" "666.0" "" "" "" "" "" "" "" "" "" "" "443.0" "394.7" "459.1" "419.0" "469.7" "586.9" "875.7" "873.9" "913.3" "641.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3644173202538667698" "False" "High" "IsMasterProtein" "Q9Y4B6" "DDB1- and CUL4-associated factor 1 OS=Homo sapiens OX=9606 GN=DCAF1 PE=1 SV=3" "0.000" "False" "25.900" "5" "9" "11" "9" "1507" "168.9" "5.06" "31.58" "9" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "" "9730" "ENSG00000145041" "DCAF1" "hsa:9730; Q2YD74; Q8TBD9; Q9HCA1; Q9UG37; Q9Y4B6" "Hippo-Merlin signaling dysregulation" "Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "0.997" "0.964" "0.986" "0.989" "0.947" "0.912" "0.946" "0.978" "0.970" "1220.3" "1216.7" "1176.7" "1202.9" "1206.4" "1155.6" "1112.5" "1154.1" "1193.1" "1183.8" "" "" "" "" "" "" "" "" "" "" "1143.4" "1006.8" "1092.5" "929.9" "1028.3" "1104.1" "1016.6" "1024.7" "1193.1" "1139.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9218003044822153883" "False" "High" "IsMasterProtein" "O95881" "Thioredoxin domain-containing protein 12 OS=Homo sapiens OX=9606 GN=TXNDC12 PE=1 SV=1" "0.000" "False" "25.873" "52" "8" "15" "8" "172" "19.2" "5.40" "49.01" "8" "other biological processes" "ER/Golgi" "other molecular function" "Pf13899" "51060" "ENSG00000117862" "TXNDC12" "B3KQS0; hsa:51060; O95881; Q5T1T4; Q96H50" "" "" "0" "0" "1.039" "1.018" "0.947" "1.008" "1.012" "1.005" "0.962" "0.966" "1.018" "2200.9" "2286.6" "2241.2" "2083.4" "2218.4" "2226.5" "2210.9" "2117.0" "2125.5" "2240.7" "" "" "" "" "" "" "" "" "" "" "2062.2" "1892.1" "2080.7" "1610.5" "1890.9" "2127.2" "2020.2" "1879.7" "2125.5" "2157.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1552754402547085825" "False" "High" "IsMasterProtein" "Q5MIZ7" "Serine/threonine-protein phosphatase 4 regulatory subunit 3B OS=Homo sapiens OX=9606 GN=PPP4R3B PE=1 SV=2" "0.000" "False" "25.857" "10" "8" "9" "6" "849" "97.4" "4.96" "34.79" "8" "other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf04802" "57223" "ENSG00000275052" "PPP4R3B" "hsa:57223; Q5MIZ7; Q6P9B0; Q86XB8; Q9BQJ0; Q9BRK2; Q9H913; Q9P2G0" "16p11.2 proximal deletion syndrome" "" "1" "0" "1.007" "0.999" "1.091" "1.027" "0.986" "1.059" "0.978" "0.962" "1.010" "1333.9" "1343.7" "1333.1" "1455.0" "1369.5" "1314.9" "1412.2" "1304.7" "1283.7" "1347.4" "" "" "" "" "" "" "" "" "" "" "1249.8" "1111.9" "1237.6" "1124.8" "1167.3" "1256.3" "1290.4" "1158.4" "1283.7" "1297.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1135638411849566769" "False" "High" "IsMasterProtein" "O76021" "Ribosomal L1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RSL1D1 PE=1 SV=3" "0.000" "False" "25.850" "17" "9" "11" "9" "490" "54.9" "10.13" "31.47" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf00687" "26156" "ENSG00000171490" "RSL1D1" "B4DJ58; D3DUG7; hsa:26156; O76021; Q2M1T7; Q6PL22; Q8IWS7; Q8WUZ1; Q9HDA9; Q9Y3Z9" "" "" "0" "0" "1.167" "1.060" "1.006" "1.113" "1.116" "1.160" "1.180" "1.161" "1.096" "985.3" "1149.8" "1044.1" "991.3" "1097.0" "1099.5" "1143.1" "1163.1" "1144.1" "1079.8" "" "" "" "" "" "" "" "" "" "" "923.2" "951.4" "969.3" "766.3" "935.1" "1050.5" "1044.5" "1032.7" "1144.1" "1039.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4061147392346931585" "False" "High" "IsMasterProtein" "P61006" "Ras-related protein Rab-8A OS=Homo sapiens OX=9606 GN=RAB8A PE=1 SV=1" "0.000" "False" "25.844" "36" "8" "14" "2" "207" "23.7" "9.07" "48.05" "8" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "4218" "ENSG00000167461" "RAB8A" "B4DEK7; hsa:4218; P24407; P61006; Q6FHV5" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape; Joubert syndrome" "RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Anchoring of the basal body to the plasma membrane; VxPx cargo-targeting to cilium; TBC/RABGAPs" "10" "2" "0.966" "1.012" "0.891" "0.977" "1.001" "0.885" "0.996" "1.020" "0.986" "1402.0" "1354.1" "1418.8" "1249.8" "1369.5" "1403.7" "1241.2" "1396.7" "1430.2" "1382.5" "" "" "" "" "" "" "" "" "" "" "1313.6" "1120.5" "1317.2" "966.1" "1167.3" "1341.1" "1134.1" "1240.1" "1430.2" "1331.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4427751732173954290" "False" "High" "IsMasterProtein" "Q99700" "Ataxin-2 OS=Homo sapiens OX=9606 GN=ATXN2 PE=1 SV=2" "0.000" "False" "25.842" "8" "11" "12" "10" "1313" "140.2" "9.57" "31.95" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity" "Pf06741, Pf07145, Pf14438" "6311" "ENSG00000204842" "ATXN2" "A6NLD4; hsa:6311; Q24JQ7; Q6ZQZ7; Q99493; Q99700" "Parkinson's disease pathway; EGF/EGFR signaling pathway" "" "2" "0" "0.984" "0.980" "0.973" "1.010" "1.010" "0.961" "0.956" "0.950" "0.997" "1667.4" "1640.7" "1634.5" "1623.2" "1684.6" "1683.3" "1602.4" "1593.4" "1583.7" "1662.6" "" "" "" "" "" "" "" "" "" "" "1562.4" "1357.7" "1517.5" "1254.8" "1435.9" "1608.2" "1464.2" "1414.8" "1583.7" "1600.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4629403927496459035" "False" "High" "IsMasterProtein" "P62987" "Ubiquitin-ribosomal protein eL40 fusion protein OS=Homo sapiens OX=9606 GN=UBA52 PE=1 SV=2" "0.000" "False" "25.832" "41" "6" "92" "6" "128" "14.7" "9.83" "278.60" "6" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf01020" "7311" "ENSG00000221983" "UBA52" "hsa:7311; P02248; P02249; P02250; P14793; P62987; P62988; Q29120; Q6LBL4; Q6LDU5; Q8WYN8; Q91887; Q91888; Q9BWD6; Q9BX98; Q9UEF2; Q9UEG1; Q9UEK8; Q9UPK7" "DNA replication; Cytoplasmic ribosomal proteins" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Circadian Clock; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; Downstream TCR signaling; Orc1 removal from chromatin; Assembly of the pre-replicative complex; Separation of Sister Chromatids; Regulation of PLK1 Activity at G2/M Transition; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; SARS-CoV-1 activates/modulates innate immune responses; VLDLR internalisation and degradation; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); FCERI mediated NF-kB activation; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; Stimuli-sensing channels; Amyloid fiber formation; Fanconi Anemia Pathway; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; KEAP1-NFE2L2 pathway; Aggrephagy; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 HD Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Peroxisomal protein import; Regulation of TP53 Degradation; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; ER Quality Control Compartment (ERQC); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Signaling by ALK fusions and activated point mutants; Regulation of signaling by CBL; Metalloprotease DUBs; Regulation of necroptotic cell death; Oncogene Induced Senescence; Cyclin D associated events in G1; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Negative regulation of FLT3; Downregulation of ERBB2:ERBB3 signaling; Cargo recognition for clathrin-mediated endocytosis; Interferon alpha/beta signaling; Inactivation of CSF3 (G-CSF) signaling; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Regulation of TP53 Activity through Methylation; Processing of DNA double-strand break ends; Regulation of BACH1 activity; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Prevention of phagosomal-lysosomal fusion; Downregulation of TGF-beta receptor signaling; HDR through Homologous Recombination (HRR); Signaling by CSF1 (M-CSF) in myeloid cells; TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex; Glycogen synthesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Modulation by Mtb of host immune system; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; Ovarian tumor domain proteases; Spry regulation of FGF signaling; RAS processing; PINK1-PRKN Mediated Mitophagy; Josephin domain DUBs; Regulation of FZD by ubiquitination; Chaperone Mediated Autophagy; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; InlA-mediated entry of Listeria monocytogenes into host cells; Formation of Incision Complex in GG-NER; Iron uptake and transport; Recognition of DNA damage by PCNA-containing replication complex; Myoclonic epilepsy of Lafora; Evasion by RSV of host interferon responses; DNA Damage Recognition in GG-NER; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Negative regulation of MAPK pathway; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); NRIF signals cell death from the nucleus; Assembly Of The HIV Virion; Dual Incision in GG-NER; Translesion Synthesis by POLH; Downregulation of ERBB4 signaling; Regulation of innate immune responses to cytosolic DNA; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Gap-filling DNA repair synthesis and ligation in GG-NER; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Regulation of PTEN localization; Pexophagy; Maturation of protein E; Maturation of protein E; FLT3 signaling by CBL mutants; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "199" "0" "1.022" "0.968" "1.004" "0.992" "0.953" "0.980" "1.015" "0.997" "0.980" "7975.5" "8153.0" "7721.4" "8010.8" "7913.9" "7602.5" "7817.8" "8092.1" "7948.8" "7816.6" "" "" "" "" "" "" "" "" "" "" "7473.0" "6746.5" "7168.4" "6192.7" "6745.6" "7263.5" "7143.4" "7185.0" "7948.8" "7526.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-901968503932970653" "False" "High" "IsMasterProtein" "Q9P2N6" "KAT8 regulatory NSL complex subunit 3 OS=Homo sapiens OX=9606 GN=KANSL3 PE=1 SV=2" "0.000" "False" "25.822" "11" "9" "13" "9" "904" "95.9" "9.39" "23.49" "9" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf20408" "55683" "ENSG00000114982" "KANSL3" "A1L184; D3DXH3; D3DXH4; hsa:55683; Q05BU4; Q6P3X2; Q6PJH6; Q86T19; Q96L64; Q9H0C9; Q9H8C9; Q9HAP8; Q9NWE5; Q9P2N6" "2q11.2 copy number variation syndrome" "HATs acetylate histones; Formation of WDR5-containing histone-modifying complexes" "3" "0" "1.063" "1.005" "1.213" "1.087" "1.016" "1.102" "1.049" "1.007" "1.083" "661.3" "702.6" "664.4" "801.9" "719.0" "671.6" "729.0" "693.7" "665.8" "716.4" "" "" "" "" "" "" "" "" "" "" "619.6" "581.4" "616.8" "619.9" "612.8" "641.6" "666.1" "616.0" "665.8" "689.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5410140500926118897" "False" "High" "IsMasterProtein" "Q96PU4" "E3 ubiquitin-protein ligase UHRF2 OS=Homo sapiens OX=9606 GN=UHRF2 PE=1 SV=1" "0.000" "False" "25.816" "12" "9" "9" "9" "802" "89.9" "8.21" "27.29" "9" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00628, Pf02182, Pf12148" "115426" "ENSG00000147854" "UHRF2" "hsa:115426; Q5VYR1; Q5VYR3; Q659C8; Q8TAG7; Q96PU4" "" "SUMOylation of transcription cofactors" "1" "0" "1.027" "1.049" "1.048" "1.039" "1.028" "0.984" "0.986" "0.978" "1.035" "687.1" "705.9" "720.9" "719.9" "713.6" "706.7" "676.0" "677.8" "671.9" "711.0" "" "" "" "" "" "" "" "" "" "" "643.8" "584.1" "669.2" "556.5" "608.3" "675.2" "617.6" "601.8" "671.9" "684.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4417786093828078874" "False" "High" "IsMasterProtein" "Q9H1A4" "Anaphase-promoting complex subunit 1 OS=Homo sapiens OX=9606 GN=ANAPC1 PE=1 SV=1" "0.000" "False" "25.791" "5" "10" "11" "10" "1944" "216.4" "6.30" "27.91" "10" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf12859, Pf18122, Pf20518, Pf21282" "64682" "ENSG00000153107" "ANAPC1" "hsa:64682; Q2M3H8; Q9BSE6; Q9H1A4; Q9H8D0" "Cell cycle; 2q13 copy number variation syndrome" "Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "20" "0" "1.030" "1.047" "0.972" "1.025" "1.036" "0.960" "0.935" "0.957" "1.047" "1103.8" "1136.7" "1155.3" "1072.8" "1131.6" "1143.1" "1060.1" "1031.6" "1056.5" "1155.9" "" "" "" "" "" "" "" "" "" "" "1034.3" "940.6" "1072.6" "829.3" "964.5" "1092.2" "968.6" "916.0" "1056.5" "1113.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1529683512558084157" "False" "High" "IsMasterProtein" "Q4LE39" "AT-rich interactive domain-containing protein 4B OS=Homo sapiens OX=9606 GN=ARID4B PE=1 SV=2" "0.000" "False" "25.758" "7" "9" "10" "9" "1312" "147.7" "5.12" "32.17" "9" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity" "Pf01388, Pf08169, Pf11717" "51742" "ENSG00000054267" "ARID4B" "A1L465; hsa:51742; Q3MHV4; Q4LE39; Q5HY99; Q5T2C2; Q5T2C3; Q5T2C4; Q5T2C5; Q5T2C6; Q6P600; Q86UX1; Q86WR4; Q9H915; Q9NYU3; Q9NZB6; Q9NZG4; Q9P2W4; Q9UF62; Q9Y6E1" "Pathways affected in adenoid cystic carcinoma" "Potential therapeutics for SARS; NoRC negatively regulates rRNA expression; HDACs deacetylate histones" "4" "0" "1.027" "0.953" "1.001" "1.014" "0.949" "0.937" "0.938" "0.953" "0.964" "1196.9" "1229.6" "1140.8" "1198.1" "1213.7" "1136.0" "1121.8" "1123.1" "1140.4" "1153.2" "" "" "" "" "" "" "" "" "" "" "1121.4" "1017.5" "1059.1" "926.2" "1034.5" "1085.4" "1025.0" "997.2" "1140.4" "1110.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7179197342339518209" "False" "High" "IsMasterProtein" "P52907" "F-actin-capping protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=CAPZA1 PE=1 SV=3" "0.000" "False" "25.751" "37" "7" "16" "6" "286" "32.9" "5.69" "67.51" "7" "cell organization and biogenesis" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01267" "829" "ENSG00000116489" "CAPZA1" "hsa:829; P52907; Q53FQ6; Q6FHD5" "" "Sensory processing of sound by inner hair cells of the cochlea; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling" "8" "1" "0.949" "1.029" "0.975" "1.007" "0.993" "0.972" "0.983" "0.989" "0.988" "1143.1" "1084.9" "1175.9" "1114.4" "1151.5" "1135.1" "1111.2" "1124.2" "1130.3" "1129.2" "" "" "" "" "" "" "" "" "" "" "1071.1" "897.8" "1091.7" "861.5" "981.5" "1084.5" "1015.4" "998.1" "1130.3" "1087.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8263646129409186084" "False" "High" "IsMasterProtein" "Q14814" "Myocyte-specific enhancer factor 2D OS=Homo sapiens OX=9606 GN=MEF2D PE=1 SV=1" "0.000" "False" "25.745" "16" "8" "15" "6" "521" "55.9" "7.88" "47.58" "8" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4209" "ENSG00000116604; ENSG00000291761" "MEF2D" "D3DVC0; hsa:4209; Q14814; Q14815; Q5T9U5; Q5T9U6" "Energy metabolism; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; B cell receptor signaling pathway; Adipogenesis; p38 MAPK signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; EGF/EGFR signaling pathway; Gastrin signaling pathway; Modulators of TCR signaling and T cell activation; Pleural mesothelioma; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "Heme signaling; NGF-stimulated transcription; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Myogenesis" "18" "1" "0.972" "0.987" "0.970" "1.002" "0.997" "0.927" "0.924" "0.913" "0.958" "1845.1" "1792.9" "1821.8" "1789.7" "1848.6" "1839.1" "1710.5" "1704.7" "1685.0" "1768.0" "" "" "" "" "" "" "" "" "" "" "1728.9" "1483.6" "1691.3" "1383.5" "1575.7" "1757.0" "1563.0" "1513.6" "1685.0" "1702.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2588985702309620212" "False" "High" "IsMasterProtein" "O75792" "Ribonuclease H2 subunit A OS=Homo sapiens OX=9606 GN=RNASEH2A PE=1 SV=2" "0.000" "False" "25.670" "32" "8" "10" "8" "299" "33.4" "5.25" "36.79" "8" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01351" "10535" "ENSG00000104889" "RNASEH2A" "B2RCY1; hsa:10535; O75792; Q96F11" "" "" "0" "0" "1.030" "0.995" "1.039" "1.123" "1.059" "1.044" "1.066" "1.144" "1.050" "389.3" "401.1" "387.2" "404.5" "437.0" "412.2" "406.6" "414.9" "445.4" "408.6" "" "" "" "" "" "" "" "" "" "" "364.8" "331.9" "359.5" "312.7" "372.5" "393.8" "371.5" "368.4" "445.4" "393.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2982172693089125932" "False" "High" "IsMasterProtein" "P28066" "Proteasome subunit alpha type-5 OS=Homo sapiens OX=9606 GN=PSMA5 PE=1 SV=3" "0.000" "False" "25.638" "29" "6" "13" "6" "241" "26.4" "4.79" "50.34" "6" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5686" "ENSG00000143106" "PSMA5" "B2R8F6; B4E2V4; hsa:5686; P28066; Q3T1C1; Q6IBF7" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Downstream TCR signaling; Separation of Sister Chromatids; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "1.014" "0.953" "1.023" "0.944" "1.065" "0.921" "0.984" "0.994" "1.024" "2011.7" "2040.5" "1916.5" "2057.6" "1898.7" "2142.4" "1852.8" "1979.0" "2000.5" "2060.1" "" "" "" "" "" "" "" "" "" "" "1885.0" "1688.5" "1779.2" "1590.6" "1618.4" "2046.8" "1693.0" "1757.1" "2000.5" "1983.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3318503761924520630" "False" "High" "IsMasterProtein" "Q96R06" "Sperm-associated antigen 5 OS=Homo sapiens OX=9606 GN=SPAG5 PE=1 SV=2" "0.000" "False" "25.626" "8" "8" "9" "8" "1193" "134.3" "5.00" "28.78" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "" "10615" "ENSG00000076382" "SPAG5" "hsa:10615; O95213; Q96R06; Q9BWE8; Q9NT17; Q9UFE6" "" "" "0" "0" "0.973" "1.015" "0.978" "0.988" "0.977" "0.942" "0.885" "0.925" "1.003" "746.2" "725.9" "757.3" "729.9" "737.4" "729.0" "702.8" "660.1" "690.0" "748.1" "" "" "" "" "" "" "" "" "" "" "699.2" "600.7" "703.0" "564.2" "628.5" "696.5" "642.2" "586.1" "690.0" "720.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5402029241356858044" "False" "High" "IsMasterProtein" "P09936" "Ubiquitin carboxyl-terminal hydrolase isozyme L1 OS=Homo sapiens OX=9606 GN=UCHL1 PE=1 SV=2" "0.000" "False" "25.607" "36" "7" "19" "7" "223" "24.8" "5.48" "67.36" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01088" "7345" "ENSG00000154277" "UCHL1" "hsa:7345; P09936; Q4W5K6; Q71UM0" "Proteasome degradation; Parkinson's disease pathway; Hepatitis C and hepatocellular carcinoma" "UCH proteinases" "4" "0" "1.016" "0.974" "0.999" "0.962" "0.976" "0.971" "1.026" "1.010" "0.966" "2423.3" "2461.8" "2361.3" "2420.9" "2330.4" "2366.0" "2354.0" "2485.4" "2448.1" "2339.9" "" "" "" "" "" "" "" "" "" "" "2270.7" "2037.1" "2192.2" "1871.5" "1986.4" "2260.5" "2151.0" "2206.8" "2448.1" "2253.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8654613729152941586" "False" "High" "IsMasterProtein" "P23786" "Carnitine O-palmitoyltransferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=CPT2 PE=1 SV=2" "0.000" "False" "25.586" "13" "10" "11" "10" "658" "73.7" "8.18" "28.64" "10" "other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00755" "1376" "ENSG00000157184" "CPT2" "B2R6S0; hsa:1376; P23786; Q5SW68; Q9BQ26" "Fatty acid beta-oxidation; PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Thermogenesis; Mitochondrial fatty acid oxidation disorders" "PPARA activates gene expression; Carnitine metabolism" "9" "0" "1.016" "1.013" "1.016" "1.010" "1.057" "0.997" "0.998" "0.983" "1.017" "1206.5" "1226.0" "1221.9" "1225.7" "1218.7" "1274.9" "1203.0" "1203.9" "1186.5" "1227.6" "" "" "" "" "" "" "" "" "" "" "1130.5" "1014.5" "1134.3" "947.5" "1038.8" "1218.1" "1099.2" "1068.9" "1186.5" "1182.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2236984144033134213" "False" "High" "IsMasterProtein" "Q9NV70" "Exocyst complex component 1 OS=Homo sapiens OX=9606 GN=EXOC1 PE=1 SV=4" "0.000" "False" "25.559" "10" "8" "8" "8" "894" "101.9" "6.61" "28.63" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf09763, Pf15277, Pf20654" "55763" "ENSG00000090989" "EXOC1" "hsa:55763; Q504V4; Q8WUE7; Q96T15; Q9NV70; Q9NZE4" "Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "4" "0" "0.993" "1.002" "0.966" "0.965" "0.996" "0.890" "0.956" "0.911" "0.984" "1333.1" "1323.3" "1336.4" "1288.4" "1286.0" "1327.4" "1186.2" "1274.3" "1214.6" "1311.5" "" "" "" "" "" "" "" "" "" "" "1249.1" "1095.0" "1240.7" "996.0" "1096.1" "1268.2" "1083.9" "1131.4" "1214.6" "1262.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3443446084982214279" "False" "High" "IsMasterProtein" "Q9UN37" "Vacuolar protein sorting-associated protein 4A OS=Homo sapiens OX=9606 GN=VPS4A PE=1 SV=1" "0.000" "False" "25.559" "19" "10" "13" "5" "437" "48.9" "7.80" "37.22" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00004, Pf04212, Pf09336, Pf17862" "27183" "ENSG00000132612" "VPS4A" "B2RCB7; hsa:27183; Q8TF07; Q9UI03; Q9UN37; Q9Y582" "Ebola virus infection in host; Ciliary landscape" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III" "6" "0" "1.026" "1.013" "1.052" "1.018" "1.022" "0.952" "0.930" "0.933" "0.974" "1048.6" "1075.7" "1062.0" "1103.0" "1067.9" "1071.6" "997.9" "974.8" "977.8" "1021.7" "" "" "" "" "" "" "" "" "" "" "982.5" "890.1" "986.0" "852.7" "910.3" "1023.8" "911.9" "865.5" "977.8" "983.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5625477449042213507" "False" "High" "IsMasterProtein" "P04179" "Superoxide dismutase [Mn], mitochondrial OS=Homo sapiens OX=9606 GN=SOD2 PE=1 SV=3" "0.000" "False" "25.558" "27" "8" "10" "8" "222" "24.7" "8.25" "37.74" "8" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00081, Pf02777" "6648" "ENSG00000291237" "SOD2" "B2R7R1; B3KUK2; B4DL20; B4E3K9; E1P5A9; P04179; P78434; Q16792; Q5TCM1; Q96EE6; Q9P2Z3" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; VEGFA-VEGFR2 signaling; Oxidative stress response" "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Detoxification of Reactive Oxygen Species; Transcriptional activation of mitochondrial biogenesis; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "10" "0" "1.008" "1.011" "0.959" "1.019" "0.964" "0.910" "0.996" "1.015" "0.972" "2129.5" "2146.4" "2152.5" "2041.3" "2170.9" "2053.8" "1937.2" "2120.3" "2162.1" "2070.2" "" "" "" "" "" "" "" "" "" "" "1995.4" "1776.1" "1998.3" "1578.0" "1850.4" "1962.2" "1770.1" "1882.6" "2162.1" "1993.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2707692795518285071" "False" "High" "IsMasterProtein" "Q567U6" "Coiled-coil domain-containing protein 93 OS=Homo sapiens OX=9606 GN=CCDC93 PE=1 SV=2" "0.000" "False" "25.554" "15" "10" "12" "10" "631" "73.2" "8.15" "38.74" "10" "transport" "other cytoplasmic organelle;other cell component" "" "Pf09762, Pf21673" "54520" "ENSG00000125633" "CCDC93" "A8K3V7; hsa:54520; Q4LE78; Q53TJ2; Q567U6; Q8TBX5; Q9H6R5; Q9NV15" "" "" "0" "0" "1.028" "1.022" "1.031" "1.060" "1.027" "1.021" "1.011" "1.006" "1.041" "924.4" "950.0" "945.1" "953.4" "979.7" "949.7" "944.1" "934.3" "929.9" "962.2" "" "" "" "" "" "" "" "" "" "" "866.2" "786.1" "877.4" "737.0" "835.1" "907.4" "862.6" "829.6" "929.9" "926.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5135100836873347765" "False" "High" "IsMasterProtein" "Q5T200" "Zinc finger CCCH domain-containing protein 13 OS=Homo sapiens OX=9606 GN=ZC3H13 PE=1 SV=1" "0.000" "False" "25.550" "5" "9" "10" "9" "1668" "196.5" "9.42" "28.87" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00642" "23091" "ENSG00000123200" "ZC3H13" "A2A323; hsa:23091; O94936; Q5T1Z9; Q5T200; Q7Z7J3; Q8NDT6; Q9H0L6" "" "" "0" "0" "1.062" "0.959" "1.209" "1.157" "1.114" "1.514" "1.462" "1.374" "1.192" "525.2" "558.0" "503.5" "635.0" "607.9" "585.3" "795.1" "768.1" "721.6" "626.3" "" "" "" "" "" "" "" "" "" "" "492.1" "461.7" "467.4" "490.9" "518.1" "559.2" "726.5" "682.0" "721.6" "603.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7235259727744776076" "False" "High" "IsMasterProtein" "Q7Z4W1" "L-xylulose reductase OS=Homo sapiens OX=9606 GN=DCXR PE=1 SV=2" "0.000" "False" "25.541" "38" "8" "13" "8" "244" "25.9" "8.10" "40.14" "8" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf13561" "51181" "ENSG00000169738" "DCXR" "hsa:51181; Q7Z4W1; Q9BTZ3; Q9UHY9" "" "Formation of xylulose-5-phosphate; Essential pentosuria" "2" "0" "0.961" "0.982" "1.055" "1.021" "0.986" "1.017" "1.040" "0.965" "0.972" "1249.0" "1199.7" "1226.3" "1318.0" "1275.1" "1231.4" "1270.5" "1299.0" "1205.6" "1213.7" "" "" "" "" "" "" "" "" "" "" "1170.4" "992.8" "1138.4" "1018.9" "1086.8" "1176.5" "1160.9" "1153.4" "1205.6" "1168.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5765443992663171126" "False" "High" "IsMasterProtein" "Q86UE8" "Serine/threonine-protein kinase tousled-like 2 OS=Homo sapiens OX=9606 GN=TLK2 PE=1 SV=2" "0.000" "False" "25.530" "11" "10" "14" "5" "772" "87.6" "8.41" "44.60" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "11011" "ENSG00000146872" "TLK2" "D3DU07; hsa:11011; Q86UE8; Q9UKI7; Q9Y4F7" "miRNA regulation of DNA damage response; DNA damage response" "" "2" "4" "0.950" "0.994" "0.960" "0.990" "0.984" "0.969" "0.985" "1.005" "1.000" "1977.7" "1879.0" "1965.1" "1898.6" "1958.3" "1945.1" "1915.6" "1948.0" "1987.7" "1978.1" "" "" "" "" "" "" "" "" "" "" "1853.1" "1554.8" "1824.4" "1467.7" "1669.2" "1858.4" "1750.3" "1729.6" "1987.7" "1904.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7016247097338811422" "False" "High" "IsMasterProtein" "Q9NW64" "Pre-mRNA-splicing factor RBM22 OS=Homo sapiens OX=9606 GN=RBM22 PE=1 SV=1" "0.000" "False" "25.527" "21" "9" "14" "9" "420" "46.9" "8.54" "39.67" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf21369" "55696" "ENSG00000086589" "RBM22" "A6NDM5; B4DLI9; hsa:55696; O95607; Q9NW64" "" "mRNA Splicing - Major Pathway" "1" "0" "0.955" "1.015" "0.936" "0.991" "1.000" "1.028" "1.078" "1.034" "0.980" "2546.5" "2430.8" "2585.1" "2384.6" "2524.5" "2547.4" "2618.5" "2745.7" "2632.5" "2496.3" "" "" "" "" "" "" "" "" "" "" "2386.1" "2011.4" "2399.9" "1843.4" "2151.8" "2433.8" "2392.6" "2437.9" "2632.5" "2403.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2662699924812854810" "False" "High" "IsMasterProtein" "Q9P219" "Protein Daple OS=Homo sapiens OX=9606 GN=CCDC88C PE=1 SV=3" "0.000" "False" "25.520" "4" "10" "12" "10" "2028" "228.1" "6.23" "28.75" "10" "cell-cell signaling;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf19047" "440193" "ENSG00000015133" "CCDC88C" "hsa:440193; Q69YK1; Q7L1M2; Q86SX7; Q8IYG8; Q9P219" "Ectoderm differentiation; Ectoderm differentiation" "Negative regulation of TCF-dependent signaling by DVL-interacting proteins" "3" "0" "0.930" "0.972" "1.040" "0.986" "0.895" "1.070" "0.942" "0.932" "0.979" "668.1" "621.4" "649.1" "694.9" "658.7" "598.0" "714.6" "629.2" "622.9" "653.9" "" "" "" "" "" "" "" "" "" "" "626.0" "514.2" "602.6" "537.2" "561.4" "571.3" "653.0" "558.7" "622.9" "629.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1311899877800093537" "False" "High" "IsMasterProtein" "Q9H0K6" "Pseudouridylate synthase PUS7L OS=Homo sapiens OX=9606 GN=PUS7L PE=1 SV=1" "0.000" "False" "25.498" "13" "9" "10" "9" "701" "80.6" "7.56" "25.53" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01142" "83448" "ENSG00000129317" "PUS7L" "B3KUJ1; hsa:83448; Q05CU0; Q6AHZ3; Q6NUP2; Q9H0K6" "" "" "0" "0" "1.017" "1.015" "1.131" "1.032" "1.010" "1.124" "0.998" "0.974" "1.053" "453.9" "461.8" "461.0" "513.6" "468.6" "458.3" "510.2" "453.2" "442.2" "477.9" "" "" "" "" "" "" "" "" "" "" "425.3" "382.1" "427.9" "397.0" "399.4" "437.8" "466.1" "402.4" "442.2" "460.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7333180136300150104" "False" "High" "IsMasterProtein" "Q96S44" "EKC/KEOPS complex subunit TP53RK OS=Homo sapiens OX=9606 GN=TP53RK PE=1 SV=2" "0.000" "False" "25.496" "32" "8" "10" "8" "253" "28.1" "9.54" "31.88" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf06293" "112858" "ENSG00000172315" "TP53RK" "B3KU44; hsa:112858; Q3T977; Q5JZ01; Q6NZ60; Q96FM7; Q96S44; Q9NQE6" "" "tRNA modification in the nucleus and cytosol; Regulation of TP53 Activity through Phosphorylation" "2" "0" "0.990" "1.005" "0.950" "0.927" "0.983" "0.946" "0.965" "0.975" "1.012" "1192.2" "1180.2" "1197.9" "1132.0" "1105.0" "1172.3" "1127.4" "1150.3" "1162.8" "1206.7" "" "" "" "" "" "" "" "" "" "" "1117.1" "976.6" "1112.1" "875.1" "941.9" "1120.0" "1030.2" "1021.3" "1162.8" "1161.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2869717489525171844" "False" "High" "IsMasterProtein" "O60306" "RNA helicase aquarius OS=Homo sapiens OX=9606 GN=AQR PE=1 SV=4" "0.000" "False" "25.496" "6" "9" "11" "9" "1485" "171.2" "6.37" "32.53" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13086, Pf13087, Pf16399, Pf21143, Pf21144" "9716" "ENSG00000021776" "AQR" "A0JP17; A5YKK3; hsa:9716; O60306; Q2YDX9; Q6IRU8; Q6PIC8" "" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "5" "0" "1.005" "0.955" "1.033" "0.989" "0.985" "1.125" "1.019" "1.000" "1.025" "884.8" "889.3" "845.4" "914.0" "875.4" "871.9" "995.5" "902.1" "884.8" "906.7" "" "" "" "" "" "" "" "" "" "" "829.1" "735.9" "784.8" "706.5" "746.2" "833.0" "909.6" "800.9" "884.8" "873.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1583280322088088435" "False" "High" "IsMasterProtein" "Q9NPF4" "tRNA N6-adenosine threonylcarbamoyltransferase OS=Homo sapiens OX=9606 GN=OSGEP PE=1 SV=1" "0.000" "False" "25.491" "26" "7" "9" "7" "335" "36.4" "6.35" "29.83" "7" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00814" "55644" "ENSG00000092094; ENSG00000291794" "OSGEP" "hsa:55644; Q6IAC3; Q9NPF4" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.911" "0.975" "0.977" "0.961" "0.954" "0.938" "0.949" "0.981" "0.944" "1074.4" "978.5" "1047.5" "1049.6" "1032.9" "1025.1" "1007.9" "1019.8" "1053.8" "1014.5" "" "" "" "" "" "" "" "" "" "" "1006.7" "809.7" "972.5" "811.4" "880.4" "979.4" "920.9" "905.5" "1053.8" "976.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2214301499697937672" "False" "High" "IsMasterProtein" "Q96C86" "m7GpppX diphosphatase OS=Homo sapiens OX=9606 GN=DCPS PE=1 SV=2" "0.000" "False" "25.489" "24" "8" "10" "8" "337" "38.6" "6.38" "36.65" "8" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05652, Pf11969" "28960" "ENSG00000110063" "DCPS" "hsa:28960; Q8NHL8; Q96C86; Q9Y2S5" "" "mRNA decay by 3' to 5' exoribonuclease" "1" "0" "1.007" "1.000" "1.043" "1.026" "1.039" "1.007" "1.056" "1.030" "0.986" "1394.6" "1404.4" "1394.5" "1455.0" "1431.4" "1449.4" "1404.9" "1472.8" "1436.1" "1375.2" "" "" "" "" "" "" "" "" "" "" "1306.7" "1162.1" "1294.6" "1124.8" "1220.1" "1384.7" "1283.7" "1307.7" "1436.1" "1324.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2160621710341352314" "False" "High" "IsMasterProtein" "O14964" "Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Homo sapiens OX=9606 GN=HGS PE=1 SV=1" "0.000" "False" "25.470" "10" "9" "10" "9" "777" "86.1" "6.16" "27.72" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf01363, Pf12210" "9146" "ENSG00000185359" "HGS" "hsa:9146; O14964; Q9NR36" "TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway" "Lysosome Vesicle Biogenesis; Endosomal Sorting Complex Required For Transport (ESCRT); Ub-specific processing proteases; RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Inhibition of membrane repair; Prevention of phagosomal-lysosomal fusion; RHOBTB3 ATPase cycle" "16" "0" "0.958" "0.846" "0.963" "0.879" "0.864" "1.318" "0.916" "0.789" "0.937" "2592.5" "2484.2" "2194.4" "2497.4" "2277.5" "2239.9" "3416.0" "2375.5" "2046.6" "2428.7" "" "" "" "" "" "" "" "" "" "" "2429.1" "2055.6" "2037.2" "1930.6" "1941.3" "2140.0" "3121.3" "2109.2" "2046.6" "2338.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8283014115765105916" "False" "High" "IsMasterProtein" "Q9UP83" "Conserved oligomeric Golgi complex subunit 5 OS=Homo sapiens OX=9606 GN=COG5 PE=1 SV=4" "0.000" "False" "25.460" "10" "9" "9" "9" "860" "94.8" "6.60" "28.73" "9" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;cytosol;ER/Golgi;nucleus" "" "Pf10392, Pf20649" "10466" "ENSG00000164597" "COG5" "A4D0R6; A4D0R7; hsa:10466; O14555; O95008; Q6NUL5; Q9UP83" "" "Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network; COPI-mediated anterograde transport" "3" "0" "1.055" "0.953" "1.145" "1.037" "0.957" "1.109" "1.017" "0.996" "1.024" "740.5" "781.4" "705.9" "847.6" "768.1" "708.7" "821.3" "753.3" "737.4" "758.1" "" "" "" "" "" "" "" "" "" "" "693.8" "646.6" "655.3" "655.3" "654.7" "677.1" "750.4" "668.8" "737.4" "729.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9199223731198630068" "False" "High" "IsMasterProtein" "Q9UIJ7" "GTP:AMP phosphotransferase AK3, mitochondrial OS=Homo sapiens OX=9606 GN=AK3 PE=1 SV=4" "0.000" "False" "25.459" "38" "9" "12" "9" "227" "25.6" "9.16" "36.51" "9" "other metabolic processes;stress response" "mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "50808" "ENSG00000147853" "AK3" "B4DP58; D3DRI1; E7ET30; hsa:50808; Q5VYW6; Q9H576; Q9HC01; Q9NPB4; Q9UIJ7" "" "Factors involved in megakaryocyte development and platelet production" "1" "0" "0.926" "1.011" "0.958" "0.990" "1.017" "0.972" "0.986" "0.933" "0.970" "1493.0" "1382.2" "1508.8" "1430.3" "1477.6" "1519.0" "1451.7" "1472.3" "1392.8" "1448.6" "" "" "" "" "" "" "" "" "" "" "1398.9" "1143.8" "1400.7" "1105.7" "1259.5" "1451.2" "1326.5" "1307.2" "1392.8" "1394.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3010766793389346536" "False" "High" "IsMasterProtein" "P0DP25" "Calmodulin-3 OS=Homo sapiens OX=9606 GN=CALM3 PE=1 SV=1" "0.000" "False" "25.458" "43" "6" "28" "6" "149" "16.8" "4.22" "98.72" "6" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf13499" "801; 805; 808" "ENSG00000160014" "CALM3" "hsa:801; hsa:805; hsa:808; P02593; P0DP25; P62158; P70667; P99014; Q13942; Q53S29; Q61379; Q61380; Q96HK3" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Myometrial relaxation and contraction pathways; G protein signaling pathways; Ras signaling; Melanoma; Endochondral ossification; Endochondral ossification with skeletal dysplasias; CAMKK2 pathway; Glycogen synthesis and degradation; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; G13 signaling pathway; Calcium regulation in cardiac cells" "" "17" "0" "1.018" "0.957" "1.001" "0.968" "0.936" "0.918" "0.989" "0.916" "0.941" "4610.9" "4694.3" "4412.4" "4614.7" "4464.6" "4315.8" "4234.0" "4559.5" "4224.8" "4340.3" "" "" "" "" "" "" "" "" "" "" "4320.4" "3884.4" "4096.3" "3567.4" "3805.5" "4123.3" "3868.7" "4048.4" "4224.8" "4179.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625848183831329232" "False" "High" "IsMasterProtein" "Q6VMQ6" "Activating transcription factor 7-interacting protein 1 OS=Homo sapiens OX=9606 GN=ATF7IP PE=1 SV=3" "0.000" "False" "25.443" "10" "8" "11" "8" "1270" "136.3" "4.70" "36.45" "8" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf16788, Pf16794" "55729" "ENSG00000171681" "ATF7IP" "F5GX74; G3V1U0; hsa:55729; Q4G0T9; Q6P3T3; Q6VMQ6; Q86XW5; Q9NVJ9; Q9NWC2; Q9Y4X8" "" "PKMTs methylate histone lysines" "1" "0" "0.986" "0.968" "0.963" "1.037" "1.001" "0.955" "1.040" "1.011" "1.014" "1007.7" "993.7" "975.6" "970.9" "1045.3" "1008.5" "962.7" "1048.5" "1018.5" "1021.4" "" "" "" "" "" "" "" "" "" "" "944.2" "822.3" "905.7" "750.5" "891.0" "963.5" "879.7" "930.9" "1018.5" "983.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4473457085686512926" "False" "High" "IsMasterProtein" "Q16186" "Proteasomal ubiquitin receptor ADRM1 OS=Homo sapiens OX=9606 GN=ADRM1 PE=1 SV=2" "0.000" "False" "25.438" "20" "8" "13" "8" "407" "42.1" "5.07" "33.79" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04683, Pf16550" "11047" "ENSG00000130706" "ADRM1" "A0PKB1; hsa:11047; Q16186; Q96FJ7; Q9H1P2" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "Ub-specific processing proteases; UCH proteinases" "4" "0" "0.924" "0.962" "0.933" "0.925" "0.931" "0.943" "0.956" "0.977" "0.925" "986.9" "911.7" "949.6" "920.9" "913.1" "918.6" "930.3" "943.0" "964.4" "912.6" "" "" "" "" "" "" "" "" "" "" "924.7" "754.4" "881.6" "711.9" "778.3" "877.6" "850.0" "837.3" "964.4" "878.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7824076810458492012" "False" "High" "IsMasterProtein" "P05165" "Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Homo sapiens OX=9606 GN=PCCA PE=1 SV=4" "0.000" "False" "25.435" "12" "9" "10" "9" "728" "80.0" "7.52" "24.22" "9" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00289, Pf00364, Pf02785, Pf02786, Pf18140" "5095" "ENSG00000175198" "PCCA" "B4DKY8; B4DPF9; C9JPQ8; hsa:5095; P05165; Q15979; Q8WXQ7" "Primary ovarian insufficiency" "Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; Propionyl-CoA catabolism" "4" "0" "0.943" "0.942" "0.985" "0.999" "1.025" "1.017" "1.042" "1.031" "0.985" "1238.6" "1168.4" "1167.0" "1220.3" "1237.5" "1269.1" "1259.5" "1290.9" "1277.5" "1219.7" "" "" "" "" "" "" "" "" "" "" "1160.5" "966.8" "1083.4" "943.4" "1054.9" "1212.5" "1150.8" "1146.2" "1277.5" "1174.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1416539979039474058" "False" "High" "IsMasterProtein" "Q99426" "Tubulin-folding cofactor B OS=Homo sapiens OX=9606 GN=TBCB PE=1 SV=2" "0.000" "False" "25.417" "34" "8" "10" "8" "244" "27.3" "5.15" "39.36" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf01302, Pf14560" "1155" "ENSG00000105254" "TBCB" "hsa:1155; O00111; O00674; O14728; Q6FGY5; Q99426" "" "Post-chaperonin tubulin folding pathway" "1" "0" "1.018" "0.934" "0.912" "0.925" "0.964" "0.912" "0.918" "0.951" "0.942" "2838.4" "2889.2" "2650.8" "2587.2" "2625.9" "2736.0" "2587.5" "2607.0" "2699.1" "2674.9" "" "" "" "" "" "" "" "" "" "" "2659.5" "2390.8" "2460.9" "2000.0" "2238.3" "2614.0" "2364.3" "2314.7" "2699.1" "2575.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8766016140567224551" "False" "High" "IsMasterProtein" "Q08380" "Galectin-3-binding protein OS=Homo sapiens OX=9606 GN=LGALS3BP PE=1 SV=1" "0.000" "False" "25.413" "14" "8" "11" "8" "585" "65.3" "5.27" "39.28" "8" "cell adhesion;stress response;transport;signal transduction" "non-structural extracellular;other membranes;other cell component" "other molecular function" "Pf00530, Pf07707" "3959" "ENSG00000108679" "LGALS3BP" "hsa:3959; Q08380; Q7M4S0; Q9UCH8; Q9UCH9; Q9UCI0" "Network map of SARS-CoV-2 signaling pathway; 11p11.2 copy number variation syndrome" "Platelet degranulation" "3" "0" "0.965" "0.971" "0.917" "0.955" "0.948" "0.923" "0.944" "0.942" "0.940" "1593.4" "1537.2" "1547.1" "1461.3" "1522.2" "1511.3" "1471.4" "1504.2" "1501.5" "1498.2" "" "" "" "" "" "" "" "" "" "" "1493.0" "1272.0" "1436.3" "1129.7" "1297.5" "1443.9" "1344.5" "1335.6" "1501.5" "1442.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7583524308725557668" "False" "High" "IsMasterProtein" "Q96J01" "THO complex subunit 3 OS=Homo sapiens OX=9606 GN=THOC3 PE=1 SV=1" "0.000" "False" "25.390" "25" "8" "13" "8" "351" "38.7" "6.09" "36.56" "8" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00400, Pf07676, Pf12894" "84321" "ENSG00000051596" "THOC3" "hsa:84321; Q6NZ53; Q96J01" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "0.984" "1.061" "1.023" "1.065" "1.122" "1.066" "1.087" "1.106" "1.065" "979.5" "964.1" "1039.0" "1002.3" "1043.4" "1099.3" "1044.6" "1064.5" "1083.2" "1043.6" "" "" "" "" "" "" "" "" "" "" "917.8" "797.7" "964.6" "774.9" "889.3" "1050.3" "954.5" "945.2" "1083.2" "1004.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1852807762900550805" "False" "High" "IsMasterProtein" "P28070" "Proteasome subunit beta type-4 OS=Homo sapiens OX=9606 GN=PSMB4 PE=1 SV=4" "0.000" "False" "25.377" "32" "6" "11" "6" "264" "29.2" "5.97" "41.71" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00227" "5692" "ENSG00000159377" "PSMB4" "B2R9L3; hsa:5692; P28070; P31148; Q5SZS5; Q6IBI4; Q969L6" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "FCERI mediated NF-kB activation; Regulation of expression of SLITs and ROBOs; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.950" "0.975" "0.991" "0.896" "0.930" "0.907" "0.886" "1.023" "0.930" "974.9" "925.8" "950.4" "966.6" "873.1" "907.0" "883.9" "863.6" "997.0" "907.0" "" "" "" "" "" "" "" "" "" "" "913.5" "766.1" "882.3" "747.2" "744.2" "866.5" "807.7" "766.8" "997.0" "873.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3853404113387134869" "False" "High" "IsMasterProtein" "Q9UK59" "Lariat debranching enzyme OS=Homo sapiens OX=9606 GN=DBR1 PE=1 SV=2" "0.000" "False" "25.368" "18" "8" "9" "8" "544" "61.5" "5.47" "23.58" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00149, Pf05011" "51163" "ENSG00000138231" "DBR1" "hsa:51163; Q96GH0; Q9NXQ6; Q9UK59" "" "" "0" "0" "0.950" "0.994" "1.059" "1.018" "1.019" "1.210" "0.953" "0.958" "0.962" "334.8" "318.2" "332.7" "354.5" "340.7" "341.1" "405.1" "319.1" "320.7" "321.9" "" "" "" "" "" "" "" "" "" "" "313.7" "263.3" "308.9" "274.0" "290.4" "325.9" "370.1" "283.3" "320.7" "310.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2819715853452011200" "False" "High" "IsMasterProtein" "Q8WUD4" "Coiled-coil domain-containing protein 12 OS=Homo sapiens OX=9606 GN=CCDC12 PE=1 SV=1" "0.000" "False" "25.361" "50" "8" "10" "8" "166" "19.2" "7.34" "37.85" "8" "" "nucleus" "" "Pf08315" "151903" "ENSG00000160799" "CCDC12" "hsa:151903; Q8N8I4; Q8WUD4" "" "mRNA Splicing - Major Pathway" "1" "0" "1.073" "1.052" "1.028" "1.078" "1.105" "1.174" "1.135" "1.207" "1.143" "1562.1" "1676.3" "1643.8" "1606.2" "1684.5" "1725.5" "1833.5" "1773.5" "1885.5" "1785.3" "" "" "" "" "" "" "" "" "" "" "1463.7" "1387.1" "1526.0" "1241.6" "1435.8" "1648.6" "1675.3" "1574.7" "1885.5" "1719.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4145241579063427930" "False" "High" "IsMasterProtein" "P68400" "Casein kinase II subunit alpha OS=Homo sapiens OX=9606 GN=CSNK2A1 PE=1 SV=1" "0.000" "False" "25.358" "23" "8" "10" "7" "391" "45.1" "7.74" "30.68" "8" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1457" "ENSG00000101266" "CSNK2A1" "B4DYS6; D3DVV8; hsa:1457; P19138; P20426; P68400; Q14013; Q5U065" "Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Pleural mesothelioma; Alzheimer's disease" "Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC" "22" "0" "1.008" "1.074" "1.043" "0.993" "1.009" "0.959" "0.989" "0.993" "1.024" "796.1" "802.5" "855.2" "830.4" "790.3" "803.7" "763.4" "787.1" "790.5" "815.4" "" "" "" "" "" "" "" "" "" "" "746.0" "664.1" "793.9" "641.9" "673.7" "767.8" "697.6" "698.9" "790.5" "785.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1376480877538073283" "False" "High" "IsMasterProtein" "Q14232" "Translation initiation factor eIF2B subunit alpha OS=Homo sapiens OX=9606 GN=EIF2B1 PE=1 SV=1" "0.000" "False" "25.335" "27" "8" "14" "8" "305" "33.7" "7.33" "36.68" "8" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "1967" "ENSG00000111361" "EIF2B1" "A6NLY9; B4DGX0; hsa:1967; Q14232; Q3SXP4" "Translation factors" "Recycling of eIF2:GDP" "2" "0" "0.959" "0.970" "0.958" "0.936" "0.986" "0.953" "0.974" "0.946" "0.931" "992.2" "951.7" "962.3" "950.4" "928.8" "978.5" "945.9" "966.3" "938.7" "923.4" "" "" "" "" "" "" "" "" "" "" "929.6" "787.5" "893.4" "734.7" "791.7" "934.9" "864.3" "858.0" "938.7" "889.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4989435524198560061" "False" "High" "IsMasterProtein" "P48506" "Glutamate--cysteine ligase catalytic subunit OS=Homo sapiens OX=9606 GN=GCLC PE=1 SV=2" "0.000" "False" "25.313" "14" "9" "11" "8" "637" "72.7" "6.09" "31.02" "9" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf03074" "2729" "ENSG00000001084" "GCLC" "hsa:2729; P48506; Q14399" "Glutathione metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Aryl hydrocarbon receptor pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; One-carbon metabolism and related pathways; Oxidative stress response; Ferroptosis; NRF2-ARE regulation; Vitamin D-sensitive calcium signaling in depression; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway" "Glutathione synthesis and recycling; NFE2L2 regulating anti-oxidant/detoxification enzymes; Defective GCLC causes HAGGSD" "17" "0" "0.991" "0.959" "1.020" "1.006" "0.978" "0.953" "0.922" "0.974" "0.980" "1273.1" "1261.6" "1221.4" "1299.1" "1280.4" "1244.8" "1213.1" "1173.6" "1240.3" "1247.4" "" "" "" "" "" "" "" "" "" "" "1192.9" "1044.0" "1133.9" "1004.2" "1091.4" "1189.3" "1108.4" "1042.0" "1240.3" "1201.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8984223167418137130" "False" "High" "IsMasterProtein" "P62633" "CCHC-type zinc finger nucleic acid binding protein OS=Homo sapiens OX=9606 GN=CNBP PE=1 SV=1" "0.000" "False" "25.310" "47" "8" "12" "8" "177" "19.5" "7.71" "37.96" "8" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098" "7555" "ENSG00000169714" "CNBP" "A8K7V4; B2RAV9; B4DP17; D3DNB9; D3DNC0; D3DNC1; E9PDR7; hsa:7555; P20694; P62633; Q4JGY0; Q4JGY1; Q5QJR0; Q5U0E9; Q6PJI7; Q96NV3" "" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "1" "0" "1.015" "1.062" "1.015" "1.015" "0.959" "0.600" "0.909" "0.965" "1.010" "375.0" "380.8" "398.2" "380.6" "380.8" "359.7" "225.1" "341.0" "361.8" "378.8" "" "" "" "" "" "" "" "" "" "" "351.4" "315.1" "369.7" "294.2" "324.6" "343.7" "205.7" "302.8" "361.8" "364.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6970631393786121187" "False" "High" "IsMasterProtein" "Q8WU79" "Stromal membrane-associated protein 2 OS=Homo sapiens OX=9606 GN=SMAP2 PE=1 SV=1" "0.000" "False" "25.298" "19" "9" "11" "8" "429" "46.8" "8.87" "36.61" "9" "" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "64744" "ENSG00000084070" "SMAP2" "B2R7T1; B7Z5B5; B7Z8V2; D3DPV2; hsa:64744; Q5QPL2; Q8WU79; Q96C93; Q9NST2; Q9UJL8" "" "" "0" "0" "1.001" "1.003" "0.990" "1.042" "1.022" "0.858" "0.973" "0.952" "0.990" "1153.9" "1155.2" "1157.0" "1142.6" "1202.0" "1179.4" "989.8" "1122.5" "1098.1" "1141.9" "" "" "" "" "" "" "" "" "" "" "1081.2" "955.9" "1074.2" "883.3" "1024.6" "1126.9" "904.4" "996.6" "1098.1" "1099.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6249152470973198342" "False" "High" "IsMasterProtein" "Q9NYZ3" "G2 and S phase-expressed protein 1 OS=Homo sapiens OX=9606 GN=GTSE1 PE=1 SV=4" "0.000" "False" "25.271" "12" "7" "8" "7" "739" "78.5" "9.23" "24.65" "7" "cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf15259" "51512" "ENSG00000075218" "GTSE1" "B0QYM3; hsa:51512; Q20WK2; Q53GX5; Q5R3I6; Q6DHX4; Q9BRE0; Q9NYZ3; Q9UGZ9; Q9Y557" "" "G2/M Checkpoints; The role of GTSE1 in G2/M progression after G2 checkpoint" "2" "0" "1.091" "1.024" "1.067" "1.090" "1.076" "1.033" "0.899" "0.970" "1.018" "717.2" "782.5" "734.5" "765.4" "781.9" "771.7" "740.7" "644.7" "696.1" "730.2" "" "" "" "" "" "" "" "" "" "" "672.0" "647.5" "681.9" "591.7" "666.5" "737.3" "676.8" "572.4" "696.1" "703.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8735053905858643513" "False" "High" "IsMasterProtein" "Q16401" "26S proteasome non-ATPase regulatory subunit 5 OS=Homo sapiens OX=9606 GN=PSMD5 PE=1 SV=3" "0.000" "False" "25.243" "15" "9" "14" "9" "504" "56.2" "5.48" "43.28" "9" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf10508" "5711" "ENSG00000095261" "PSMD5" "B4DZM8; hsa:5711; Q15045; Q16401; Q4VXG8" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway" "Antigen processing: Ubiquitination & Proteasome degradation; ER-Phagosome pathway; Regulation of expression of SLITs and ROBOs; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Downstream TCR signaling; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "61" "0" "0.891" "0.945" "0.926" "0.899" "0.955" "0.870" "0.898" "0.913" "0.918" "1078.4" "960.3" "1018.7" "998.2" "969.4" "1029.8" "937.7" "967.9" "984.6" "990.5" "" "" "" "" "" "" "" "" "" "" "1010.4" "794.6" "945.7" "771.6" "826.3" "983.9" "856.8" "859.4" "984.6" "953.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824521577804774203" "False" "High" "IsMasterProtein" "Q53GS9" "Ubiquitin carboxyl-terminal hydrolase 39 OS=Homo sapiens OX=9606 GN=USP39 PE=1 SV=2" "0.000" "False" "25.210" "17" "9" "10" "9" "565" "65.3" "8.91" "29.05" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00443, Pf02148" "10713" "ENSG00000168883" "USP39" "A8K086; B3KM40; B4DHT4; D6W5L4; G5E9H0; hsa:10713; Q53GS9; Q6NX47; Q96RK9; Q9BV89; Q9H381; Q9P050; Q9Y310" "" "mRNA Splicing - Major Pathway" "1" "0" "0.987" "1.004" "0.974" "1.010" "0.971" "1.073" "1.083" "1.003" "0.954" "991.1" "978.6" "994.8" "965.4" "1001.3" "962.0" "1063.6" "1073.3" "993.8" "945.6" "" "" "" "" "" "" "" "" "" "" "928.6" "809.8" "923.5" "746.3" "853.5" "919.1" "971.9" "953.0" "993.8" "910.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6598258105920115633" "False" "High" "IsMasterProtein" "Q5TDH0" "Protein DDI1 homolog 2 OS=Homo sapiens OX=9606 GN=DDI2 PE=1 SV=1" "0.000" "False" "25.196" "25" "8" "11" "8" "399" "44.5" "5.05" "36.91" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf09668" "84301" "ENSG00000197312" "DDI2" "A8KAE1; hsa:84301; Q5TDH0; Q7RTZ0; Q9BRT1" "" "" "0" "0" "1.000" "0.998" "1.026" "0.985" "1.055" "0.959" "0.960" "1.020" "0.989" "977.3" "977.7" "975.3" "1003.0" "962.7" "1031.3" "937.4" "938.6" "997.1" "966.3" "" "" "" "" "" "" "" "" "" "" "915.7" "809.1" "905.4" "775.4" "820.6" "985.3" "856.6" "833.3" "997.1" "930.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3425744660855709231" "False" "High" "IsMasterProtein" "O60568" "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 OS=Homo sapiens OX=9606 GN=PLOD3 PE=1 SV=1" "0.000" "False" "25.184" "12" "10" "12" "10" "738" "84.7" "6.05" "33.37" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;other membranes;ER/Golgi" "other molecular function" "Pf03171" "8985" "ENSG00000106397" "PLOD3" "B2R6W6; hsa:8985; O60568; Q540C3" "VEGFA-VEGFR2 signaling; IL-18 signaling pathway" "Collagen biosynthesis and modifying enzymes" "3" "0" "1.003" "0.964" "1.022" "0.992" "0.992" "0.934" "0.954" "0.956" "1.000" "1031.4" "1034.2" "994.0" "1054.4" "1023.0" "1023.1" "962.9" "984.4" "986.1" "1031.2" "" "" "" "" "" "" "" "" "" "" "966.5" "855.8" "922.8" "815.1" "872.0" "977.4" "879.8" "874.0" "986.1" "992.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-933507358187812304" "False" "High" "IsMasterProtein" "P48634" "Protein PRRC2A OS=Homo sapiens OX=9606 GN=PRRC2A PE=1 SV=3" "0.000" "False" "25.145" "4" "8" "10" "6" "2157" "228.7" "9.45" "34.23" "8" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "" "Pf07001" "7916" "ENSG00000204469; ENSG00000206427; ENSG00000225164; ENSG00000225748; ENSG00000226618; ENSG00000231370; ENSG00000231825" "PRRC2A" "B0UX77; B0UZE9; B0UZL3; hsa:7916; O95875; P48634; Q05BK4; Q4LE37; Q5SQ29; Q5SQ30; Q5ST84; Q5STX6; Q5STX7; Q68DW9; Q6P9P7; Q6PIN1; Q8MGQ9; Q96QC6" "" "" "0" "0" "0.969" "0.910" "0.962" "1.098" "1.029" "1.252" "1.268" "1.271" "1.109" "587.6" "569.1" "534.6" "565.0" "644.9" "604.3" "735.8" "744.8" "747.0" "651.4" "" "" "" "" "" "" "" "" "" "" "550.5" "470.9" "496.3" "436.8" "549.7" "577.4" "672.3" "661.3" "747.0" "627.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4971008711368622204" "False" "High" "IsMasterProtein" "Q9BVW5" "TIMELESS-interacting protein OS=Homo sapiens OX=9606 GN=TIPIN PE=1 SV=2" "0.000" "False" "25.136" "28" "8" "10" "8" "301" "34.5" "4.82" "32.13" "8" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07962" "54962" "ENSG00000075131" "TIPIN" "B2CW64; hsa:54962; Q9BVW5; Q9NWZ6" "" "Processing of DNA double-strand break ends" "1" "0" "0.993" "0.942" "0.959" "0.926" "0.971" "0.971" "0.998" "0.970" "0.972" "721.9" "717.0" "680.2" "692.1" "668.7" "701.3" "701.0" "720.7" "700.0" "701.8" "" "" "" "" "" "" "" "" "" "" "676.4" "593.3" "631.5" "535.0" "570.0" "670.0" "640.5" "639.9" "700.0" "675.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7900354501110065761" "False" "High" "IsMasterProtein" "O00170" "AH receptor-interacting protein OS=Homo sapiens OX=9606 GN=AIP PE=1 SV=3" "0.000" "False" "25.123" "30" "9" "12" "9" "330" "37.6" "6.42" "39.97" "9" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00254" "9049" "ENSG00000110711" "AIP" "A0SZW3; A0SZW4; A0SZW5; A0SZW6; G9I2H4; hsa:9049; O00170; Q2M3Q2; Q99606" "Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway" "Aryl hydrocarbon receptor signalling; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "5" "0" "1.092" "0.973" "1.040" "1.029" "0.995" "0.974" "0.980" "1.092" "1.060" "842.2" "919.9" "819.6" "875.6" "867.0" "838.3" "820.0" "825.8" "919.7" "892.6" "" "" "" "" "" "" "" "" "" "" "789.2" "761.2" "760.9" "676.9" "739.0" "800.9" "749.3" "733.2" "919.7" "859.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3347831162215749093" "False" "High" "IsMasterProtein" "Q9UEW8" "STE20/SPS1-related proline-alanine-rich protein kinase OS=Homo sapiens OX=9606 GN=STK39 PE=1 SV=3" "0.000" "False" "25.115" "14" "7" "10" "7" "545" "59.4" "6.29" "28.31" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12202" "27347" "ENSG00000198648" "STK39" "O14774; Q53S90; Q53SL7; Q53SS1; Q9UER4; Q9UEW8; X5D9C8" "" "" "0" "0" "1.049" "1.002" "1.113" "1.146" "1.020" "1.025" "0.982" "1.027" "1.113" "492.2" "516.2" "493.4" "547.6" "564.0" "502.1" "504.6" "483.2" "505.4" "547.6" "" "" "" "" "" "" "" "" "" "" "461.2" "427.1" "458.1" "423.3" "480.7" "479.7" "461.0" "429.0" "505.4" "527.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4848628119440074227" "False" "High" "IsMasterProtein" "P30038" "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH4A1 PE=1 SV=3" "0.000" "False" "25.094" "14" "8" "11" "8" "563" "61.7" "8.07" "39.77" "8" "other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00171" "8659" "ENSG00000159423" "ALDH4A1" "A8K1Q7; B4DGE4; D2D4A3; hsa:8659; P30038; Q16882; Q53HU4; Q5JNV6; Q8IZ38; Q96IF0; Q9UDI6" "22q11.2 copy number variation syndrome; p53 transcriptional gene network" "Glyoxylate metabolism and glycine degradation; Proline catabolism" "4" "0" "1.002" "1.015" "0.956" "0.978" "1.044" "0.923" "0.954" "1.008" "1.006" "1649.3" "1653.1" "1674.4" "1576.8" "1612.3" "1722.2" "1522.9" "1572.7" "1662.9" "1659.5" "" "" "" "" "" "" "" "" "" "" "1545.3" "1367.9" "1554.4" "1219.0" "1374.3" "1645.4" "1391.6" "1396.4" "1662.9" "1597.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5319872679741064952" "False" "High" "IsMasterProtein" "P22570" "NADPH:adrenodoxin oxidoreductase, mitochondrial OS=Homo sapiens OX=9606 GN=FDXR PE=1 SV=3" "0.000" "False" "25.092" "20" "11" "13" "11" "491" "53.8" "8.44" "38.30" "11" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf07992" "2232" "ENSG00000161513" "FDXR" "B4DDI7; B4DHX5; B4DQQ4; B4DX24; B7Z7G2; E7EQC1; hsa:2232; P22570; Q13716; Q4PJI0; Q9BU12" "Iron-sulfur cluster biogenesis" "Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin" "5" "0" "0.953" "1.029" "1.038" "1.021" "0.968" "1.002" "0.982" "0.963" "1.013" "1167.9" "1113.1" "1201.6" "1212.6" "1192.4" "1130.1" "1170.0" "1147.4" "1124.9" "1183.2" "" "" "" "" "" "" "" "" "" "" "1094.3" "921.1" "1115.5" "937.4" "1016.3" "1079.7" "1069.0" "1018.8" "1124.9" "1139.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2439136335340173205" "False" "High" "IsMasterProtein" "P22681" "E3 ubiquitin-protein ligase CBL OS=Homo sapiens OX=9606 GN=CBL PE=1 SV=2" "0.000" "False" "25.091" "11" "8" "10" "8" "906" "99.6" "6.54" "29.46" "8" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00097, Pf00627, Pf02262, Pf02761, Pf02762" "867" "ENSG00000110395" "CBL" "A3KMP8; P22681" "RANKL/RANK signaling pathway; Prolactin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; IL-4 signaling pathway; MET in type 1 papillary renal cell carcinoma; EGF/EGFR signaling pathway; Insulin signaling; IL-2 signaling pathway; 4p16.3 copy number variation; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "Signaling by CSF1 (M-CSF) in myeloid cells; Regulation of signaling by CBL; Regulation of KIT signaling; Negative regulation of FLT3; Cargo recognition for clathrin-mediated endocytosis; Interleukin-6 signaling; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Spry regulation of FGF signaling; TGF-beta receptor signaling activates SMADs; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; FLT3 signaling by CBL mutants" "39" "0" "1.063" "1.057" "1.105" "1.082" "1.021" "1.065" "1.050" "1.017" "1.049" "824.0" "876.2" "871.3" "910.1" "891.8" "841.5" "877.2" "864.9" "837.8" "864.7" "" "" "" "" "" "" "" "" "" "" "772.1" "725.0" "808.9" "703.6" "760.2" "804.0" "801.5" "767.9" "837.8" "832.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2834511568131292996" "False" "High" "IsMasterProtein" "O00329" "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform OS=Homo sapiens OX=9606 GN=PIK3CD PE=1 SV=2" "0.000" "False" "25.054" "9" "9" "10" "9" "1044" "119.4" "7.18" "27.27" "9" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792, Pf00794, Pf02192" "5293" "ENSG00000171608" "PIK3CD" "A6NCG0; G1FFP1; hsa:5293; O00329; O15445; Q5SR49" "AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; IL-3 signaling pathway; Focal adhesion; Overview of nanoparticle effects; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Neural crest cell migration during development; Neural crest cell migration in cancer; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; G13 signaling pathway; Acute myeloid leukemia; Interferon type I signaling pathways; ErbB signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PIP3 activates AKT signaling; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL" "56" "0" "0.976" "1.016" "1.055" "0.995" "0.968" "0.950" "0.931" "0.959" "1.001" "984.4" "960.5" "1000.0" "1038.2" "979.7" "953.1" "934.7" "916.5" "944.0" "985.7" "" "" "" "" "" "" "" "" "" "" "922.4" "794.8" "928.3" "802.5" "835.1" "910.6" "854.1" "813.7" "944.0" "949.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8454971752249747449" "False" "High" "IsMasterProtein" "Q9BSD7" "Cancer-related nucleoside-triphosphatase OS=Homo sapiens OX=9606 GN=NTPCR PE=1 SV=1" "0.000" "False" "25.049" "51" "8" "15" "8" "190" "20.7" "9.54" "49.23" "8" "" "" "other molecular function" "Pf03266" "84284" "ENSG00000135778" "NTPCR" "hsa:84284; Q9BSD7" "" "" "0" "0" "0.951" "0.988" "0.981" "0.973" "0.976" "0.935" "0.985" "0.950" "0.969" "1588.1" "1510.7" "1569.4" "1558.3" "1546.0" "1550.4" "1484.3" "1564.0" "1508.1" "1538.9" "" "" "" "" "" "" "" "" "" "" "1488.1" "1250.1" "1457.0" "1204.7" "1317.8" "1481.3" "1356.2" "1388.7" "1508.1" "1481.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8966374980505742475" "False" "High" "IsMasterProtein" "Q15047" "Histone-lysine N-methyltransferase SETDB1 OS=Homo sapiens OX=9606 GN=SETDB1 PE=1 SV=1" "0.000" "False" "25.011" "7" "9" "10" "9" "1291" "143.1" "6.02" "32.99" "9" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00856, Pf01429, Pf05033, Pf18300, Pf18358, Pf18359" "9869" "ENSG00000143379" "SETDB1" "A6NEW2; hsa:9869; Q15047; Q5SZD8; Q5SZD9; Q5SZE0; Q5SZE7; Q96GM9" "Histone modifications; Pleural mesothelioma" "PKMTs methylate histone lysines" "3" "0" "0.980" "1.019" "1.008" "1.005" "0.957" "0.975" "0.922" "0.909" "1.007" "816.2" "799.8" "831.3" "822.3" "820.6" "780.8" "796.0" "752.9" "741.6" "822.1" "" "" "" "" "" "" "" "" "" "" "764.7" "661.8" "771.8" "635.7" "699.4" "746.0" "727.4" "668.5" "741.6" "791.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3445317151605985554" "False" "High" "IsMasterProtein" "Q13356" "RING-type E3 ubiquitin-protein ligase PPIL2 OS=Homo sapiens OX=9606 GN=PPIL2 PE=1 SV=1" "0.000" "False" "24.993" "20" "9" "10" "9" "520" "58.8" "8.78" "27.96" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00160" "23759" "ENSG00000100023" "PPIL2" "Q13356; Q13357; Q8TAH2; Q9BWR8" "" "mRNA Splicing - Major Pathway; Basigin interactions" "2" "0" "1.007" "1.017" "0.983" "1.038" "1.024" "0.991" "1.032" "1.008" "1.023" "1295.2" "1303.9" "1316.8" "1273.3" "1344.2" "1326.2" "1283.2" "1336.2" "1306.2" "1324.9" "" "" "" "" "" "" "" "" "" "" "1213.6" "1079.0" "1222.5" "984.3" "1145.8" "1267.0" "1172.5" "1186.4" "1306.2" "1275.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7307907366133705571" "False" "High" "IsMasterProtein" "Q9UJY4" "ADP-ribosylation factor-binding protein GGA2 OS=Homo sapiens OX=9606 GN=GGA2 PE=1 SV=3" "0.000" "False" "24.989" "15" "8" "11" "7" "613" "67.1" "6.55" "43.32" "8" "transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "23062" "ENSG00000103365" "GGA2" "D3DWF0; hsa:23062; O14564; Q9NYN2; Q9UJY4; Q9UPS2" "" "Amyloid fiber formation; TBC/RABGAPs" "2" "0" "0.979" "0.982" "0.954" "0.968" "1.001" "0.871" "0.887" "0.900" "0.989" "1271.5" "1244.3" "1249.1" "1212.7" "1230.8" "1272.8" "1107.7" "1127.7" "1144.0" "1257.1" "" "" "" "" "" "" "" "" "" "" "1191.4" "1029.7" "1159.6" "937.5" "1049.1" "1216.1" "1012.2" "1001.3" "1144.0" "1210.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1174014872672808776" "False" "High" "IsMasterProtein" "Q96PP9" "Guanylate-binding protein 4 OS=Homo sapiens OX=9606 GN=GBP4 PE=1 SV=2" "0.000" "False" "24.978" "15" "10" "11" "10" "640" "73.1" "6.02" "35.46" "10" "stress response" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02263, Pf02841" "115361" "ENSG00000162654" "GBP4" "B2R630; hsa:115361; Q05D63; Q6NSL0; Q86T99; Q96PP9" "" "Interferon gamma signaling" "1" "0" "0.982" "1.012" "0.954" "0.973" "0.961" "0.935" "0.971" "0.935" "0.992" "1932.2" "1897.7" "1956.0" "1842.4" "1879.3" "1856.8" "1805.7" "1876.7" "1805.8" "1916.0" "" "" "" "" "" "" "" "" "" "" "1810.5" "1570.3" "1815.9" "1424.2" "1601.8" "1774.0" "1649.9" "1666.3" "1805.8" "1844.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5348588292702008792" "False" "High" "IsMasterProtein" "O94888" "UBX domain-containing protein 7 OS=Homo sapiens OX=9606 GN=UBXN7 PE=1 SV=2" "0.000" "False" "24.969" "18" "8" "10" "8" "489" "54.8" "5.16" "33.49" "8" "protein metabolism;other metabolic processes" "other membranes;cytosol;ER/Golgi;nucleus" "other molecular function" "Pf00789, Pf13899, Pf14555" "26043" "ENSG00000163960" "UBXN7" "D3DXB3; hsa:26043; O94888; Q6ZP77; Q86X20; Q8N327" "3q29 copy number variation syndrome" "Neddylation; KEAP1-NFE2L2 pathway" "3" "0" "1.021" "0.945" "1.008" "1.061" "1.055" "1.043" "1.025" "0.979" "1.001" "1245.4" "1271.6" "1176.9" "1256.0" "1321.1" "1313.6" "1299.2" "1276.7" "1219.1" "1246.4" "" "" "" "" "" "" "" "" "" "" "1167.0" "1052.2" "1092.6" "970.9" "1126.1" "1255.0" "1187.1" "1133.6" "1219.1" "1200.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3953719107085229180" "False" "High" "IsMasterProtein" "Q9Y6K9" "NF-kappa-B essential modulator OS=Homo sapiens OX=9606 GN=IKBKG PE=1 SV=2" "0.000" "False" "24.944" "22" "10" "12" "10" "419" "48.2" "5.71" "37.91" "10" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf11577, Pf16516, Pf18414" "8517" "ENSG00000269335" "IKBKG" "hsa:8517; Q7LBY6; Q7Z7F1; Q9Y6K9" "Nucleotide-binding oligomerization domain (NOD) pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; ATM signaling in development and disease ; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Network map of SARS-CoV-2 signaling pathway; Acute myeloid leukemia; T-cell receptor signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway" "PKR-mediated signaling; Downstream TCR signaling; NOD1/2 Signaling Pathway; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; activated TAK1 mediates p38 MAPK activation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; Ovarian tumor domain proteases; RIP-mediated NFkB activation via ZBP1; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; SUMOylation of immune response proteins" "76" "0" "1.017" "0.987" "1.033" "1.015" "1.011" "1.007" "1.024" "0.943" "1.006" "928.6" "944.5" "916.3" "959.7" "942.6" "939.1" "934.9" "951.1" "875.8" "934.5" "" "" "" "" "" "" "" "" "" "" "870.1" "781.6" "850.6" "741.9" "803.4" "897.2" "854.3" "844.5" "875.8" "899.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6142056770574276442" "False" "High" "IsMasterProtein" "Q96T58" "Msx2-interacting protein OS=Homo sapiens OX=9606 GN=SPEN PE=1 SV=1" "0.000" "False" "24.918" "3" "11" "12" "11" "3664" "402.0" "7.64" "29.98" "11" "signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf07744, Pf20808, Pf20809, Pf20810" "23013" "ENSG00000065526" "SPEN" "hsa:23013; Q96T58; Q9H9A8; Q9NWH5; Q9UQ01; Q9Y556" "Notch signaling pathway" "RHOBTB1 GTPase cycle" "2" "0" "0.966" "0.989" "1.015" "0.988" "1.003" "1.114" "1.098" "1.081" "1.003" "826.5" "798.6" "817.4" "839.0" "816.8" "829.2" "920.8" "907.6" "893.0" "828.6" "" "" "" "" "" "" "" "" "" "" "774.4" "660.8" "758.9" "648.6" "696.2" "792.2" "841.4" "805.8" "893.0" "797.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5448927889689110920" "False" "High" "IsMasterProtein" "Q16539" "Mitogen-activated protein kinase 14 OS=Homo sapiens OX=9606 GN=MAPK14 PE=1 SV=3" "0.000" "False" "24.912" "23" "8" "14" "7" "360" "41.3" "5.78" "50.45" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1432" "ENSG00000112062" "MAPK14" "A6ZJ92; A8K6P4; B0LPH0; B5TY32; hsa:1432; O60776; Q13083; Q14084; Q16539; Q8TDX0" "Physiological and pathological hypertrophy of the heart; Angiogenesis; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; Alpha 6 beta 4 signaling pathway; Amyotrophic lateral sclerosis (ALS); Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; IL-4 signaling pathway; p38 MAPK signaling pathway; Oxidative stress response; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Regulatory circuits of the STAT3 signaling pathway; Leukocyte-intrinsic Hippo pathway functions; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; Pleural mesothelioma; Th17 cell differentiation pathway; GDNF signaling; Hippocampal synaptogenesis and neurogenesis; Comprehensive IL-17A signaling; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; IL-19 signaling pathway; Interferon type I signaling pathways; T-cell receptor signaling pathway; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Monoamine transport; Toll-like receptor signaling pathway" "Neutrophil degranulation; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; Oxidative Stress Induced Senescence; Activation of the AP-1 family of transcription factors; Regulation of TP53 Activity through Phosphorylation; VEGFA-VEGFR2 Pathway; DSCAM interactions; RHO GTPases Activate NADPH Oxidases; Myogenesis; ADP signalling through P2Y purinoceptor 1; p38MAPK events; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; ERK/MAPK targets; KSRP (KHSRP) binds and destabilizes mRNA; Platelet sensitization by LDL; CD163 mediating an anti-inflammatory response" "92" "1" "0.980" "1.035" "0.972" "1.013" "1.016" "0.952" "0.969" "0.971" "0.981" "1207.2" "1182.9" "1249.5" "1173.3" "1222.9" "1226.2" "1148.8" "1169.4" "1172.7" "1184.3" "" "" "" "" "" "" "" "" "" "" "1131.1" "978.8" "1160.0" "907.0" "1042.3" "1171.6" "1049.7" "1038.3" "1172.7" "1140.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2957906910240928632" "False" "High" "IsMasterProtein" "P22033" "Methylmalonyl-CoA mutase, mitochondrial OS=Homo sapiens OX=9606 GN=MMUT PE=1 SV=4" "0.000" "False" "24.873" "12" "9" "12" "9" "750" "83.1" "6.93" "33.81" "9" "other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf01642, Pf02310" "4594" "ENSG00000146085" "MMUT" "A8K953; hsa:4594; P22033; Q5SYZ3; Q96B11; Q9UD64" "Vitamin B12 metabolism; Amino acid metabolism" "Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM; Cobalamin (Cbl) metabolism" "6" "0" "0.972" "0.991" "0.960" "0.993" "0.986" "0.960" "0.966" "1.012" "0.994" "870.1" "845.9" "862.7" "835.1" "864.4" "858.3" "835.3" "840.5" "880.7" "864.7" "" "" "" "" "" "" "" "" "" "" "815.3" "700.0" "800.9" "645.6" "736.8" "820.0" "763.2" "746.3" "880.7" "832.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3231455898363948540" "False" "High" "IsMasterProtein" "Q15833" "Syntaxin-binding protein 2 OS=Homo sapiens OX=9606 GN=STXBP2 PE=1 SV=2" "0.000" "False" "24.866" "16" "9" "9" "9" "593" "66.4" "6.55" "27.63" "9" "cell-cell signaling;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00995" "6813" "ENSG00000076944" "STXBP2" "B4E175; E7EQD5; hsa:6813; Q15833; Q9BU65" "Splicing factor NOVA regulated synaptic proteins; Insulin signaling" "Platelet degranulation ; Other interleukin signaling" "4" "0" "1.007" "1.005" "1.002" "1.028" "1.040" "1.012" "1.075" "1.068" "1.031" "1531.6" "1542.2" "1539.7" "1534.3" "1574.9" "1592.9" "1550.7" "1646.1" "1635.0" "1578.9" "" "" "" "" "" "" "" "" "" "" "1435.1" "1276.1" "1429.4" "1186.1" "1342.4" "1521.9" "1416.9" "1461.6" "1635.0" "1520.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5836561258245124912" "False" "High" "IsMasterProtein" "Q6P6C2" "RNA demethylase ALKBH5 OS=Homo sapiens OX=9606 GN=ALKBH5 PE=1 SV=2" "0.000" "False" "24.864" "19" "7" "9" "7" "394" "44.2" "9.09" "25.54" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf13532" "54890" "ENSG00000091542" "ALKBH5" "B4DVJ4; D3DXC6; hsa:54890; Q6P6C2; Q9NXD6" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Reversal of alkylation damage by DNA dioxygenases" "2" "0" "0.982" "0.979" "1.113" "1.038" "1.053" "1.119" "1.008" "1.038" "1.076" "644.1" "632.7" "630.3" "716.9" "668.4" "678.4" "720.5" "649.2" "668.8" "693.3" "" "" "" "" "" "" "" "" "" "" "603.5" "523.5" "585.2" "554.2" "569.7" "648.1" "658.3" "576.4" "668.8" "667.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5760294074974619673" "False" "High" "IsMasterProtein" "O95319" "CUGBP Elav-like family member 2 OS=Homo sapiens OX=9606 GN=CELF2 PE=1 SV=1" "0.000" "False" "24.852" "16" "8" "15" "6" "508" "54.3" "8.76" "39.54" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "10659" "ENSG00000048740" "CELF2" "B7ZAN9; O95319; Q7KYU4; Q8N499; Q92950; Q96NW9; Q96RQ5; Q96RQ6; Q9UL67" "mRNA processing; Opioid receptor pathways" "" "2" "0" "1.026" "0.962" "1.014" "1.018" "1.000" "0.961" "0.923" "1.143" "1.006" "1318.9" "1352.8" "1269.0" "1337.4" "1342.6" "1318.8" "1267.5" "1217.7" "1507.3" "1326.3" "" "" "" "" "" "" "" "" "" "" "1235.8" "1119.4" "1178.1" "1033.9" "1144.4" "1260.0" "1158.2" "1081.2" "1507.3" "1277.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7625852785660981987" "False" "High" "IsMasterProtein" "Q15126" "Phosphomevalonate kinase OS=Homo sapiens OX=9606 GN=PMVK PE=1 SV=3" "0.000" "False" "24.847" "39" "7" "10" "7" "192" "22.0" "5.73" "30.31" "7" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "kinase activity;other molecular function" "Pf04275" "10654" "ENSG00000163344" "PMVK" "Q15126; Q5TZW9" "Cholesterol biosynthesis pathway; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "8" "0" "0.982" "1.018" "0.899" "0.967" "1.004" "0.936" "0.950" "0.934" "1.011" "405.2" "398.0" "412.4" "364.2" "391.9" "406.9" "379.3" "385.0" "378.5" "409.7" "" "" "" "" "" "" "" "" "" "" "379.7" "329.4" "382.9" "281.5" "334.0" "388.8" "346.6" "341.9" "378.5" "394.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7515792609303095651" "False" "High" "IsMasterProtein" "P61204" "ADP-ribosylation factor 3 OS=Homo sapiens OX=9606 GN=ARF3 PE=1 SV=2" "0.000" "False" "24.825" "34" "5" "15" "2" "181" "20.6" "7.43" "49.64" "5" "transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00025" "377" "ENSG00000134287" "ARF3" "A8K6G8; B7ZB63; hsa:377; P16587; P61204" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Synthesis of PIPs at the Golgi membrane" "3" "0" "1.006" "0.963" "1.089" "0.954" "1.109" "0.959" "0.969" "1.115" "1.025" "811.1" "815.9" "781.2" "882.9" "773.5" "899.7" "777.5" "786.3" "904.8" "831.2" "" "" "" "" "" "" "" "" "" "" "760.0" "675.1" "725.3" "682.5" "659.3" "859.5" "710.4" "698.1" "904.8" "800.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2127950675318566661" "False" "High" "IsMasterProtein" "Q9UJA5" "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 OS=Homo sapiens OX=9606 GN=TRMT6 PE=1 SV=1" "0.000" "False" "24.817" "18" "11" "15" "11" "497" "55.8" "7.55" "38.99" "11" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf04189" "51605" "ENSG00000089195" "TRMT6" "B4DUV6; hsa:51605; Q76P92; Q9BQV5; Q9UJA5; Q9ULR7; Q9Y2Z8" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.993" "0.984" "0.969" "0.995" "0.958" "0.969" "0.950" "0.983" "0.983" "2254.4" "2237.8" "2218.2" "2184.7" "2242.4" "2160.6" "2183.7" "2140.7" "2215.1" "2215.1" "" "" "" "" "" "" "" "" "" "" "2112.3" "1851.8" "2059.3" "1688.8" "1911.3" "2064.2" "1995.3" "1900.8" "2215.1" "2132.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5829960447854698720" "False" "High" "IsMasterProtein" "O43399" "Tumor protein D54 OS=Homo sapiens OX=9606 GN=TPD52L2 PE=1 SV=2" "0.000" "False" "24.816" "36" "7" "10" "7" "206" "22.2" "5.36" "38.48" "7" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf04201" "7165" "ENSG00000101150" "TPD52L2" "B4DPJ6; E1P5G7; hsa:7165; O43398; O43399; Q5JWU5; Q5JWU6; Q5JWU8; Q5U0E0; Q9H3Z6" "" "" "0" "0" "1.046" "0.951" "0.932" "0.981" "1.015" "0.975" "1.009" "0.963" "0.971" "1045.4" "1093.7" "994.5" "974.5" "1025.7" "1061.6" "1018.9" "1054.6" "1006.3" "1014.7" "" "" "" "" "" "" "" "" "" "" "979.5" "905.1" "923.3" "753.3" "874.3" "1014.2" "931.0" "936.4" "1006.3" "977.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6993572615210098163" "False" "High" "IsMasterProtein" "Q9UJV9" "Probable ATP-dependent RNA helicase DDX41 OS=Homo sapiens OX=9606 GN=DDX41 PE=1 SV=2" "0.000" "False" "24.795" "15" "9" "11" "9" "622" "69.8" "6.84" "33.08" "9" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00270, Pf00271" "51428" "ENSG00000183258" "DDX41" "B2RDC8; Q96BK6; Q96K05; Q9NT96; Q9NW04; Q9UJV9" "5q35 copy number variation" "mRNA Splicing - Major Pathway; Regulation of innate immune responses to cytosolic DNA; IRF3-mediated induction of type I IFN" "5" "0" "0.992" "1.012" "1.024" "1.046" "1.027" "1.003" "0.967" "0.957" "1.000" "416.8" "413.5" "422.0" "426.8" "436.1" "428.3" "418.1" "402.9" "399.1" "416.6" "" "" "" "" "" "" "" "" "" "" "390.6" "342.1" "391.7" "329.9" "371.7" "409.2" "382.0" "357.7" "399.1" "401.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-437633753378296153" "False" "High" "IsMasterProtein" "Q9UKI8" "Serine/threonine-protein kinase tousled-like 1 OS=Homo sapiens OX=9606 GN=TLK1 PE=1 SV=2" "0.000" "False" "24.786" "10" "9" "13" "4" "766" "86.6" "8.72" "44.88" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "nucleus" "kinase activity;other molecular function" "Pf00069" "9874" "ENSG00000198586" "TLK1" "B3KR15; B4DX87; hsa:9874; Q14150; Q8N591; Q9NYH2; Q9UKI8; Q9Y4F6" "miRNA regulation of DNA damage response; Pathways affected in adenoid cystic carcinoma; DNA damage response" "" "3" "0" "1.039" "1.034" "1.126" "1.058" "1.045" "1.127" "1.084" "1.056" "1.098" "229.2" "238.1" "237.1" "258.1" "242.5" "239.6" "258.3" "248.4" "242.0" "251.6" "" "" "" "" "" "" "" "" "" "" "214.8" "197.0" "220.1" "199.5" "206.7" "228.9" "236.0" "220.5" "242.0" "242.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3215128447752590217" "False" "High" "IsMasterProtein" "A2RUS2" "DENN domain-containing protein 3 OS=Homo sapiens OX=9606 GN=DENND3 PE=1 SV=2" "0.000" "False" "24.761" "7" "10" "14" "10" "1198" "135.8" "7.06" "34.62" "10" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00400, Pf02141, Pf03456" "22898" "ENSG00000105339" "DENND3" "A2RUS2; B7ZM28; hsa:22898; O94947; Q2TAM7; Q6ZMS6; Q96DK3" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.009" "1.054" "1.123" "1.059" "0.996" "1.018" "0.894" "0.940" "1.063" "369.2" "372.4" "389.2" "414.8" "391.1" "367.7" "376.1" "330.3" "347.0" "392.6" "" "" "" "" "" "" "" "" "" "" "346.0" "308.2" "361.4" "320.6" "333.4" "351.3" "343.6" "293.2" "347.0" "378.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1851911761268984934" "False" "High" "IsMasterProtein" "O00418" "Eukaryotic elongation factor 2 kinase OS=Homo sapiens OX=9606 GN=EEF2K PE=1 SV=2" "0.000" "False" "24.748" "11" "9" "10" "9" "725" "82.1" "5.33" "32.11" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf02816" "29904" "ENSG00000103319" "EEF2K" "hsa:29904; O00418; Q8N588" "Translation factors; AMP-activated protein kinase signaling; BDNF-TrkB signaling" "mTORC1-mediated signalling" "4" "0" "0.997" "1.002" "0.965" "0.940" "0.943" "0.819" "0.814" "0.829" "0.942" "1272.0" "1267.7" "1273.9" "1228.1" "1195.9" "1199.8" "1041.3" "1035.4" "1055.0" "1198.2" "" "" "" "" "" "" "" "" "" "" "1191.9" "1049.0" "1182.7" "949.4" "1019.4" "1146.3" "951.5" "919.3" "1055.0" "1153.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7165899401853608207" "False" "High" "IsMasterProtein" "P04424" "Argininosuccinate lyase OS=Homo sapiens OX=9606 GN=ASL PE=1 SV=4" "0.000" "False" "24.731" "21" "9" "11" "9" "464" "51.6" "6.48" "36.58" "9" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00206, Pf14698" "435" "ENSG00000126522" "ASL" "E7EMI0; E9PE48; hsa:435; P04424; Q6LDS5; Q96HS2" "Alanine and aspartate metabolism" "Urea cycle" "2" "0" "0.993" "0.978" "1.004" "1.020" "1.004" "0.983" "0.986" "0.944" "0.964" "1545.8" "1535.4" "1512.4" "1552.1" "1576.5" "1551.8" "1519.3" "1524.2" "1459.7" "1489.7" "" "" "" "" "" "" "" "" "" "" "1448.4" "1270.5" "1404.1" "1199.8" "1343.7" "1482.6" "1388.2" "1353.4" "1459.7" "1434.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8106966376198238351" "False" "High" "IsMasterProtein" "Q01844" "RNA-binding protein EWS OS=Homo sapiens OX=9606 GN=EWSR1 PE=1 SV=1" "0.000" "False" "24.672" "14" "6" "14" "6" "656" "68.4" "9.33" "51.99" "6" "" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00076, Pf00641" "2130" "ENSG00000182944" "EWSR1" "B0QYK1; hsa:2130; Q01844; Q5THL0; Q92635; Q96FE8; Q96MN4; Q96MX4; Q9BWA2" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.089" "1.000" "1.078" "1.017" "1.014" "1.031" "1.037" "1.026" "1.018" "744.5" "810.4" "744.4" "802.8" "757.2" "754.9" "767.4" "771.7" "763.6" "757.6" "" "" "" "" "" "" "" "" "" "" "697.6" "670.6" "691.0" "620.6" "645.4" "721.2" "701.2" "685.2" "763.6" "729.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9033578792166200150" "False" "High" "IsMasterProtein" "Q99729" "Heterogeneous nuclear ribonucleoprotein A/B OS=Homo sapiens OX=9606 GN=HNRNPAB PE=1 SV=2" "0.000" "False" "24.671" "21" "7" "14" "5" "332" "36.2" "8.21" "35.38" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08143" "3182" "ENSG00000197451" "HNRNPAB" "B3KNN5; D3DWP7; hsa:3182; Q04150; Q8N7U3; Q99729; Q9BQ99" "Pre-implantation embryo; mRNA processing" "" "2" "0" "1.079" "1.058" "1.053" "0.987" "1.001" "0.909" "0.964" "0.990" "0.974" "1286.0" "1387.5" "1361.1" "1354.2" "1269.9" "1287.6" "1169.2" "1239.3" "1273.5" "1252.3" "" "" "" "" "" "" "" "" "" "" "1205.0" "1148.1" "1263.6" "1046.9" "1082.4" "1230.2" "1068.4" "1100.4" "1273.5" "1205.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2971731893176673056" "False" "High" "IsMasterProtein" "O15305" "Phosphomannomutase 2 OS=Homo sapiens OX=9606 GN=PMM2 PE=1 SV=1" "0.000" "False" "24.631" "26" "7" "10" "6" "246" "28.1" "6.77" "32.67" "7" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03332" "5373" "ENSG00000140650" "PMM2" "A8K672; B7Z6R0; D3DUF3; hsa:5373; O15305" "Nephrotic syndrome; N-glycan biosynthesis; Primary ovarian insufficiency" "Defective PMM2 causes PMM2-CDG; Synthesis of GDP-mannose" "5" "0" "0.954" "1.060" "0.919" "0.995" "1.060" "0.931" "1.033" "1.013" "1.026" "1249.6" "1191.8" "1324.8" "1148.2" "1242.9" "1324.3" "1163.8" "1290.6" "1265.2" "1282.2" "" "" "" "" "" "" "" "" "" "" "1170.8" "986.2" "1229.9" "887.6" "1059.4" "1265.3" "1063.4" "1145.9" "1265.2" "1234.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6546315403352841289" "False" "High" "IsMasterProtein" "Q9Y2B0" "Protein canopy homolog 2 OS=Homo sapiens OX=9606 GN=CNPY2 PE=1 SV=1" "0.000" "False" "24.630" "32" "5" "10" "5" "182" "20.6" "4.92" "38.78" "5" "other biological processes" "ER/Golgi" "" "Pf11938" "10330" "ENSG00000257727" "CNPY2" "B2R7B9; Q9UHE9; Q9Y2B0" "" "" "0" "0" "1.074" "0.960" "1.040" "1.024" "0.980" "1.006" "0.995" "0.904" "1.011" "1477.3" "1586.6" "1418.0" "1535.9" "1512.3" "1447.9" "1486.4" "1470.4" "1335.6" "1493.9" "" "" "" "" "" "" "" "" "" "" "1384.2" "1312.9" "1316.4" "1187.3" "1289.1" "1383.3" "1358.2" "1305.5" "1335.6" "1438.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3948795116760064813" "False" "High" "IsMasterProtein" "Q7Z2Z2" "Elongation factor-like GTPase 1 OS=Homo sapiens OX=9606 GN=EFL1 PE=1 SV=2" "0.000" "False" "24.598" "8" "11" "15" "11" "1120" "125.4" "5.91" "38.83" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf14492" "79631" "ENSG00000140598" "EFL1" "A6NKY5; B7Z6I0; hsa:79631; Q7Z2Z2; Q9H8Z6" "Genetic causes of porto-sinusoidal vascular disease" "" "1" "0" "1.090" "1.081" "1.035" "1.081" "1.091" "0.917" "0.983" "1.021" "1.084" "1303.6" "1420.5" "1408.6" "1348.6" "1408.5" "1422.0" "1195.0" "1281.7" "1330.6" "1413.4" "" "" "" "" "" "" "" "" "" "" "1221.4" "1175.5" "1307.7" "1042.5" "1200.6" "1358.6" "1091.9" "1138.0" "1330.6" "1360.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8849479475208291816" "False" "High" "IsMasterProtein" "Q9H8Y5" "tRNA endonuclease ANKZF1 OS=Homo sapiens OX=9606 GN=ANKZF1 PE=1 SV=1" "0.000" "False" "24.532" "12" "9" "14" "9" "726" "80.9" "8.41" "40.66" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response" "other cell component" "other molecular function" "Pf00023, Pf18716, Pf18826" "55139" "ENSG00000163516" "ANKZF1" "hsa:55139; Q9H8Y5; Q9NVZ4" "" "" "0" "0" "1.007" "1.061" "1.082" "1.085" "1.043" "0.998" "1.032" "1.038" "1.074" "922.4" "929.2" "978.2" "998.2" "1000.9" "962.4" "920.5" "951.7" "957.1" "990.7" "" "" "" "" "" "" "" "" "" "" "864.3" "768.9" "908.1" "771.7" "853.2" "919.5" "841.1" "845.0" "957.1" "953.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3098042065705187363" "False" "High" "IsMasterProtein" "Q6IBW4" "Condensin-2 complex subunit H2 OS=Homo sapiens OX=9606 GN=NCAPH2 PE=1 SV=1" "0.000" "False" "24.513" "14" "8" "8" "8" "605" "68.2" "4.74" "27.32" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf06278, Pf16858, Pf16869" "29781" "ENSG00000025770" "NCAPH2" "B7WPH1; hsa:29781; O43788; Q13391; Q6IBW4; Q96C14; Q96GJ0; Q9BQ71; Q9BUT3; Q9BVD1" "IL-18 signaling pathway" "Condensation of Prophase Chromosomes" "2" "0" "1.056" "0.993" "1.009" "1.018" "1.018" "1.004" "0.994" "1.022" "1.052" "1018.0" "1075.2" "1010.8" "1027.4" "1036.1" "1036.2" "1021.8" "1012.2" "1040.4" "1071.4" "" "" "" "" "" "" "" "" "" "" "953.9" "889.7" "938.4" "794.2" "883.2" "990.0" "933.7" "898.7" "1040.4" "1031.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5762043181650020657" "False" "High" "IsMasterProtein" "P46109" "Crk-like protein OS=Homo sapiens OX=9606 GN=CRKL PE=1 SV=1" "0.000" "False" "24.509" "33" "8" "12" "8" "303" "33.8" "6.74" "36.54" "8" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00018, Pf07653" "1399" "ENSG00000099942" "CRKL" "A8KA44; D3DX35; hsa:1399; P46109" "Androgen receptor network in prostate cancer; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; EGF/EGFR signaling pathway; 22q11.2 copy number variation syndrome; IL-2 signaling pathway; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "Downstream signal transduction; Regulation of signaling by CBL; Erythropoietin activates RAS; Frs2-mediated activation; MET activates RAP1 and RAC1; MET receptor recycling" "22" "0" "1.078" "1.031" "1.197" "1.158" "1.072" "1.143" "1.085" "1.010" "1.038" "401.0" "432.5" "413.4" "480.2" "464.4" "429.9" "458.4" "435.0" "405.1" "416.3" "" "" "" "" "" "" "" "" "" "" "375.8" "357.8" "383.8" "371.2" "395.8" "410.7" "418.9" "386.2" "405.1" "400.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8005629595719536467" "False" "High" "IsMasterProtein" "Q12840" "Kinesin heavy chain isoform 5A OS=Homo sapiens OX=9606 GN=KIF5A PE=1 SV=2" "0.000" "False" "24.498" "8" "8" "12" "1" "1032" "117.3" "5.90" "27.68" "8" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3798" "ENSG00000155980" "KIF5A" "A6H8M5; hsa:3798; Q12840; Q4LE26" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Insulin processing; RHO GTPases activate KTN1" "7" "0" "0.979" "1.028" "1.009" "0.980" "1.014" "1.026" "1.067" "1.019" "1.004" "556.6" "544.7" "572.5" "561.4" "545.6" "564.6" "571.2" "594.1" "567.3" "559.0" "" "" "" "" "" "" "" "" "" "" "521.5" "450.8" "531.4" "434.0" "465.0" "539.4" "522.0" "527.5" "567.3" "538.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9065508386869284325" "False" "High" "IsMasterProtein" "Q9Y2L5" "Trafficking protein particle complex subunit 8 OS=Homo sapiens OX=9606 GN=TRAPPC8 PE=1 SV=2" "0.000" "False" "24.486" "5" "9" "10" "9" "1435" "160.9" "6.87" "27.83" "9" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "" "Pf12739" "22878" "ENSG00000153339" "TRAPPC8" "A0JP15; B3KME5; hsa:22878; Q9H0L2; Q9Y2L5" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "0.965" "1.002" "0.951" "1.012" "1.003" "0.937" "0.919" "0.981" "1.053" "1091.0" "1052.8" "1093.6" "1037.5" "1103.7" "1094.6" "1022.4" "1002.5" "1069.8" "1148.4" "" "" "" "" "" "" "" "" "" "" "1022.3" "871.2" "1015.2" "802.1" "940.8" "1045.8" "934.2" "890.1" "1069.8" "1105.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9188891296985920952" "False" "High" "IsMasterProtein" "P31483" "Cytotoxic granule associated RNA binding protein TIA1 OS=Homo sapiens OX=9606 GN=TIA1 PE=1 SV=3" "0.000" "False" "24.476" "22" "7" "10" "5" "386" "42.9" "7.74" "34.73" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "7072" "ENSG00000116001" "TIA1" "hsa:7072; P31483; Q53SS9; Q96B58" "" "FGFR2 alternative splicing" "1" "1" "0.990" "1.004" "0.885" "0.959" "1.030" "0.984" "0.952" "1.019" "0.981" "832.4" "823.8" "835.7" "737.0" "798.0" "857.6" "818.9" "792.6" "848.3" "816.4" "" "" "" "" "" "" "" "" "" "" "779.9" "681.7" "775.8" "569.7" "680.2" "819.3" "748.3" "703.8" "848.3" "786.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8013273140133158732" "False" "High" "IsMasterProtein" "Q9H3P7" "Golgi resident protein GCP60 OS=Homo sapiens OX=9606 GN=ACBD3 PE=1 SV=4" "0.000" "False" "24.461" "19" "8" "8" "8" "528" "60.6" "5.06" "33.16" "8" "other metabolic processes" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf00887, Pf13897" "64746" "ENSG00000182827" "ACBD3" "B2RB29; hsa:64746; Q5VTJ0; Q6P9F1; Q8IZC5; Q8N4D6; Q9H3P7; Q9H6U3" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "1.038" "1.051" "1.080" "1.066" "1.165" "1.036" "1.035" "1.118" "1.093" "861.1" "893.5" "904.7" "930.2" "917.6" "1003.0" "892.4" "891.4" "962.5" "941.4" "" "" "" "" "" "" "" "" "" "" "806.9" "739.3" "839.9" "719.1" "782.1" "958.2" "815.4" "791.5" "962.5" "906.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "657128700828351651" "False" "High" "IsMasterProtein" "Q16643" "Drebrin OS=Homo sapiens OX=9606 GN=DBN1 PE=1 SV=4" "0.000" "False" "24.450" "16" "9" "9" "9" "649" "71.4" "4.45" "34.70" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "1627" "ENSG00000113758" "DBN1" "A8MV58; B2RBG0; hsa:1627; Q16643; Q9UFZ5" "5q35 copy number variation" "RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; RHOD GTPase cycle; RHOH GTPase cycle" "5" "0" "1.052" "1.151" "1.049" "1.058" "1.099" "1.170" "1.129" "1.194" "1.105" "874.0" "919.6" "1005.8" "917.0" "924.8" "960.8" "1022.6" "987.1" "1043.4" "965.3" "" "" "" "" "" "" "" "" "" "" "818.9" "760.9" "933.8" "708.9" "788.3" "917.9" "934.4" "876.4" "1043.4" "929.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4204109305997435954" "False" "High" "IsMasterProtein" "Q07960" "Rho GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=ARHGAP1 PE=1 SV=1" "0.000" "False" "24.448" "21" "8" "11" "8" "439" "50.4" "6.29" "36.48" "8" "transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00620, Pf13716" "392" "ENSG00000175220" "ARHGAP1" "D3DQQ6; hsa:392; Q07960" "" "RHOC GTPase cycle; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle" "13" "0" "0.985" "1.033" "1.031" "1.068" "1.040" "1.068" "1.005" "0.987" "1.016" "693.9" "683.4" "717.1" "715.2" "740.9" "721.7" "741.3" "697.5" "684.7" "705.1" "" "" "" "" "" "" "" "" "" "" "650.1" "565.5" "665.7" "552.9" "631.6" "689.5" "677.3" "619.3" "684.7" "678.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6548869844035824343" "False" "High" "IsMasterProtein" "Q9UKM9" "RNA-binding protein Raly OS=Homo sapiens OX=9606 GN=RALY PE=1 SV=1" "0.000" "False" "24.448" "22" "8" "11" "8" "306" "32.4" "9.17" "37.69" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "22913" "ENSG00000125970" "RALY" "hsa:22913; Q14621; Q2M365; Q5QPL8; Q9BQX6; Q9UJE3; Q9UKM9" "" "" "0" "0" "1.009" "1.230" "0.988" "0.831" "0.854" "0.912" "0.777" "0.884" "0.969" "2103.3" "2121.5" "2586.8" "2077.6" "1746.9" "1797.0" "1918.7" "1635.3" "1860.3" "2038.3" "" "" "" "" "" "" "" "" "" "" "1970.8" "1755.5" "2401.5" "1606.1" "1489.0" "1716.8" "1753.2" "1452.0" "1860.3" "1962.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8926098929249154387" "False" "High" "IsMasterProtein" "Q9NR28" "Diablo IAP-binding mitochondrial protein OS=Homo sapiens OX=9606 GN=DIABLO PE=1 SV=1" "0.000" "False" "24.436" "35" "9" "12" "9" "239" "27.1" "5.90" "37.01" "9" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion" "" "Pf09057" "56616" "ENSG00000184047" "DIABLO" "B2RDQ0; hsa:56616; Q6W3F3; Q96LV0; Q9BT11; Q9HAV6; Q9NR28" "Apoptosis modulation and signaling; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Apoptosis; Complement system in neuronal development and plasticity" "SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria" "10" "0" "1.122" "1.045" "0.967" "0.971" "1.032" "1.201" "1.243" "1.169" "1.070" "1420.2" "1593.3" "1483.6" "1373.7" "1379.5" "1466.2" "1706.1" "1765.9" "1660.1" "1519.7" "" "" "" "" "" "" "" "" "" "" "1330.7" "1318.5" "1377.4" "1061.9" "1175.9" "1400.8" "1558.9" "1568.0" "1660.1" "1463.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7705673583208632788" "False" "High" "IsMasterProtein" "P04183" "Thymidine kinase, cytosolic OS=Homo sapiens OX=9606 GN=TK1 PE=1 SV=2" "0.000" "False" "24.425" "38" "8" "10" "8" "234" "25.5" "8.51" "31.04" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00265" "7083" "ENSG00000167900" "TK1" "B2RC58; hsa:7083; P04183; Q969V0; Q9UMG9" "Fluoropyrimidine activity; Pyrimidine metabolism" "Pyrimidine salvage; G1/S-Specific Transcription" "4" "0" "0.955" "0.982" "0.908" "0.970" "0.978" "0.901" "0.961" "0.951" "0.962" "2129.8" "2034.9" "2091.1" "1933.1" "2065.1" "2082.9" "1919.9" "2047.1" "2026.3" "2048.0" "" "" "" "" "" "" "" "" "" "" "1995.7" "1683.8" "1941.3" "1494.4" "1760.2" "1990.0" "1754.3" "1817.7" "2026.3" "1971.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9198167910452048535" "False" "High" "IsMasterProtein" "P18887" "DNA repair protein XRCC1 OS=Homo sapiens OX=9606 GN=XRCC1 PE=1 SV=3" "0.000" "False" "24.415" "12" "8" "8" "8" "633" "69.5" "6.28" "27.55" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf01834" "7515" "ENSG00000073050" "XRCC1" "hsa:7515; P18887; Q6IBS4; Q9HCB1" "Base excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Gap-filling DNA repair synthesis and ligation in TC-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; HDR through MMEJ (alt-NHEJ); Resolution of AP sites via the single-nucleotide replacement pathway; Gap-filling DNA repair synthesis and ligation in GG-NER" "8" "0" "0.888" "1.013" "1.042" "1.069" "1.072" "1.043" "0.979" "0.970" "1.022" "497.1" "441.4" "503.4" "517.8" "531.4" "532.8" "518.7" "486.5" "482.2" "508.3" "" "" "" "" "" "" "" "" "" "" "465.8" "365.3" "467.3" "400.3" "452.9" "509.1" "473.9" "432.0" "482.2" "489.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3264120083815806641" "False" "High" "IsMasterProtein" "O14737" "Programmed cell death protein 5 OS=Homo sapiens OX=9606 GN=PDCD5 PE=1 SV=3" "0.000" "False" "24.412" "58" "7" "16" "7" "125" "14.3" "6.04" "38.95" "7" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf01984" "9141" "ENSG00000105185" "PDCD5" "B4DE64; hsa:9141; O14737; Q53YC9; Q6IB70" "" "" "0" "0" "1.054" "0.998" "0.999" "1.033" "1.007" "1.032" "1.055" "1.018" "1.013" "975.8" "1028.5" "974.0" "975.1" "1007.8" "982.9" "1006.6" "1029.8" "993.2" "988.8" "" "" "" "" "" "" "" "" "" "" "914.3" "851.1" "904.3" "753.8" "859.1" "939.0" "919.8" "914.3" "993.2" "952.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6644865826182156559" "False" "High" "IsMasterProtein" "Q6DKJ4" "Nucleoredoxin OS=Homo sapiens OX=9606 GN=NXN PE=1 SV=2" "0.000" "False" "24.393" "24" "7" "9" "7" "435" "48.4" "4.97" "35.07" "7" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf13848, Pf13905" "64359" "ENSG00000167693" "NXN" "B4DXQ0; D3DTH2; hsa:64359; Q3SWW6; Q6DKJ4; Q6P3U6; Q7L4C6; Q9H9Q1" "" "" "0" "0" "0.999" "0.978" "1.019" "0.919" "0.903" "0.958" "0.981" "0.953" "0.965" "506.8" "506.4" "495.7" "516.7" "465.8" "457.4" "485.8" "497.2" "483.1" "489.1" "" "" "" "" "" "" "" "" "" "" "474.9" "419.1" "460.2" "399.4" "397.0" "437.0" "443.8" "441.5" "483.1" "471.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-220085271204376127" "False" "High" "IsMasterProtein" "O95983" "Methyl-CpG-binding domain protein 3 OS=Homo sapiens OX=9606 GN=MBD3 PE=1 SV=1" "0.000" "False" "24.378" "25" "9" "12" "7" "291" "32.8" "5.34" "36.99" "9" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429, Pf14048, Pf16564" "53615" "ENSG00000071655" "MBD3" "A8K4B7; D6W5Z2; hsa:53615; O95983; Q6PIL9; Q6PJZ9; Q86XF4" "Effect of progerin on genes involved in progeria" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "7" "1" "1.095" "1.029" "1.051" "1.029" "1.074" "1.009" "1.034" "0.997" "1.078" "1222.1" "1338.4" "1257.3" "1284.6" "1257.8" "1312.5" "1232.5" "1263.8" "1218.8" "1317.9" "" "" "" "" "" "" "" "" "" "" "1145.1" "1107.5" "1167.3" "993.1" "1072.1" "1254.0" "1126.2" "1122.1" "1218.8" "1268.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4783590985173723979" "False" "High" "IsMasterProtein" "Q96CN7" "Isochorismatase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ISOC1 PE=1 SV=3" "0.000" "False" "24.344" "23" "7" "11" "7" "298" "32.2" "7.39" "42.21" "7" "" "other cytoplasmic organelle;other cell component" "" "Pf00857" "51015" "ENSG00000066583" "ISOC1" "hsa:51015; Q7Z770; Q96CN7" "" "" "0" "0" "0.951" "0.959" "0.932" "0.924" "0.946" "0.877" "0.957" "0.932" "0.916" "1815.0" "1726.4" "1740.5" "1691.1" "1677.0" "1716.2" "1591.6" "1737.5" "1691.8" "1662.9" "" "" "" "" "" "" "" "" "" "" "1700.7" "1428.6" "1615.9" "1307.3" "1429.4" "1639.7" "1454.3" "1542.8" "1691.8" "1601.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3529380218292263569" "False" "High" "IsMasterProtein" "P05423" "DNA-directed RNA polymerase III subunit RPC4 OS=Homo sapiens OX=9606 GN=POLR3D PE=1 SV=2" "0.000" "False" "24.335" "18" "8" "10" "8" "398" "44.4" "6.98" "38.67" "8" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05132" "661" "ENSG00000168495" "POLR3D" "hsa:661; P05423; Q6FI28; Q9BPV7; Q9BPZ1; Q9BXB3" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "1.140" "1.004" "1.011" "1.027" "0.997" "0.999" "1.033" "1.086" "1.062" "799.6" "911.5" "802.6" "808.1" "821.4" "797.3" "798.4" "826.1" "868.7" "848.8" "" "" "" "" "" "" "" "" "" "" "749.2" "754.2" "745.2" "624.7" "700.1" "761.8" "729.5" "733.5" "868.7" "817.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8219779968186532826" "False" "High" "IsMasterProtein" "Q9UI26" "Importin-11 OS=Homo sapiens OX=9606 GN=IPO11 PE=1 SV=1" "0.000" "False" "24.313" "9" "9" "11" "9" "975" "112.5" "5.25" "32.33" "9" "transport" "cytosol;nucleus" "other molecular function" "Pf03810" "51194" "ENSG00000086200" "IPO11" "A6NGJ5; B4DZ73; D3DW98; hsa:51194; Q8N5R2; Q9NSJ6; Q9NVB1; Q9UI26" "" "" "0" "0" "0.963" "1.032" "1.076" "1.004" "1.016" "1.035" "1.043" "1.017" "1.050" "741.2" "714.1" "764.7" "797.4" "744.5" "753.1" "767.2" "773.2" "753.7" "778.1" "" "" "" "" "" "" "" "" "" "" "694.5" "590.9" "709.9" "616.4" "634.6" "719.6" "701.0" "686.5" "753.7" "749.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1707703891335855171" "False" "High" "IsMasterProtein" "Q7Z478" "ATP-dependent RNA helicase DHX29 OS=Homo sapiens OX=9606 GN=DHX29 PE=1 SV=2" "0.000" "False" "24.309" "6" "10" "11" "9" "1369" "155.1" "8.09" "28.00" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "54505" "ENSG00000067248" "DHX29" "hsa:54505; O75549; Q63HN0; Q63HN3; Q7Z478; Q8IWW2; Q8N3A1; Q9UMH2" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.053" "1.062" "1.028" "1.066" "1.103" "1.139" "1.080" "1.058" "1.060" "1020.0" "1073.7" "1083.4" "1048.9" "1087.7" "1125.2" "1161.8" "1102.0" "1079.6" "1080.8" "" "" "" "" "" "" "" "" "" "" "955.8" "888.5" "1005.8" "810.8" "927.2" "1075.0" "1061.5" "978.5" "1079.6" "1040.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "960640284500961057" "False" "High" "IsMasterProtein" "Q13426" "DNA repair protein XRCC4 OS=Homo sapiens OX=9606 GN=XRCC4 PE=1 SV=2" "0.000" "False" "24.302" "23" "8" "10" "8" "336" "38.3" "4.98" "35.82" "8" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06632" "7518" "ENSG00000152422" "XRCC4" "A8K3X4; hsa:7518; Q13426; Q9BS72; Q9UP94" "Non-homologous end joining; Male infertility; DNA repair pathways, full network; Primary ovarian insufficiency" "SUMOylation of DNA damage response and repair proteins; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation" "7" "0" "0.957" "0.971" "1.051" "0.985" "0.956" "1.005" "1.001" "0.964" "0.979" "1690.9" "1618.2" "1641.7" "1776.7" "1665.3" "1617.2" "1699.1" "1692.9" "1630.3" "1655.3" "" "" "" "" "" "" "" "" "" "" "1584.3" "1339.0" "1524.1" "1373.5" "1419.5" "1545.1" "1552.5" "1503.2" "1630.3" "1593.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3524460011519656721" "False" "High" "IsMasterProtein" "P50749" "Ras association domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RASSF2 PE=1 SV=1" "0.000" "False" "24.299" "29" "8" "12" "8" "326" "37.8" "8.84" "33.68" "8" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity" "Pf00788, Pf16517" "9770" "ENSG00000101265" "RASSF2" "A6NIX9; A8K5Z3; hsa:9770; P50749; Q17S06; Q53HD0; Q6AHZ2; Q8IZA5" "Pleural mesothelioma" "" "1" "0" "1.031" "1.019" "1.094" "1.063" "1.023" "0.927" "0.890" "0.917" "0.994" "496.7" "511.9" "505.9" "543.4" "528.2" "508.1" "460.5" "441.9" "455.4" "494.0" "" "" "" "" "" "" "" "" "" "" "465.4" "423.6" "469.7" "420.0" "450.2" "485.4" "420.7" "392.4" "455.4" "475.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6935074334363071802" "False" "High" "IsMasterProtein" "O00762" "Ubiquitin-conjugating enzyme E2 C OS=Homo sapiens OX=9606 GN=UBE2C PE=1 SV=1" "0.000" "False" "24.288" "34" "6" "11" "6" "179" "19.6" "7.37" "30.23" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "11065" "ENSG00000175063" "UBE2C" "A6NP33; E1P5N7; G3XAB7; hsa:11065; O00762" "Gastric cancer network 1; Gastric cancer network 2" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "21" "0" "1.082" "0.931" "1.015" "0.909" "0.979" "0.887" "0.868" "0.960" "0.993" "916.1" "991.4" "853.0" "929.8" "832.9" "896.6" "812.2" "794.8" "879.3" "909.3" "" "" "" "" "" "" "" "" "" "" "858.4" "820.4" "791.9" "718.8" "709.9" "856.6" "742.2" "705.7" "879.3" "875.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8211975543562738760" "False" "High" "IsMasterProtein" "P13984" "General transcription factor IIF subunit 2 OS=Homo sapiens OX=9606 GN=GTF2F2 PE=1 SV=2" "0.000" "False" "24.269" "30" "9" "13" "9" "249" "28.4" "9.23" "42.83" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf02270, Pf17683" "2963" "ENSG00000188342" "GTF2F2" "A6NNS5; hsa:2963; P13984; Q5W0H3" "Eukaryotic transcription initiation" "Estrogen-dependent gene expression; Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "33" "0" "0.962" "1.020" "0.924" "0.965" "1.022" "0.981" "0.988" "0.988" "0.989" "2603.7" "2505.3" "2655.3" "2406.7" "2513.3" "2660.8" "2553.7" "2573.6" "2572.5" "2576.1" "" "" "" "" "" "" "" "" "" "" "2439.6" "2073.1" "2465.1" "1860.5" "2142.3" "2542.1" "2333.4" "2285.1" "2572.5" "2480.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1371524125527115551" "False" "High" "IsMasterProtein" "Q9NZM3" "Intersectin-2 OS=Homo sapiens OX=9606 GN=ITSN2 PE=1 SV=3" "0.000" "False" "24.257" "5" "9" "11" "9" "1697" "193.3" "8.12" "32.92" "9" "transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00168, Pf00621, Pf07653, Pf12763, Pf14604, Pf16652" "50618" "ENSG00000198399" "ITSN2" "O95062; Q15812; Q9HAK4; Q9NXE6; Q9NYG0; Q9NZM2; Q9NZM3; Q9ULG4" "" "Cargo recognition for clathrin-mediated endocytosis; RHOU GTPase cycle" "3" "0" "0.987" "1.027" "0.961" "1.022" "1.077" "1.005" "1.016" "1.025" "1.038" "1134.4" "1120.0" "1165.5" "1090.1" "1158.8" "1222.1" "1140.1" "1152.5" "1162.4" "1177.1" "" "" "" "" "" "" "" "" "" "" "1062.9" "926.8" "1082.0" "842.7" "987.7" "1167.6" "1041.7" "1023.3" "1162.4" "1133.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1860975273197737865" "False" "High" "IsMasterProtein" "P19784" "Casein kinase II subunit alpha' OS=Homo sapiens OX=9606 GN=CSNK2A2 PE=1 SV=1" "0.000" "False" "24.223" "28" "8" "11" "7" "350" "41.2" "8.56" "33.41" "8" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1459" "ENSG00000070770" "CSNK2A2" "hsa:1459; P19784" "Alzheimer's disease and miRNA effects; Allograft rejection; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Measles virus infection; Pleural mesothelioma; Alzheimer's disease; HDAC6 interactions in the central nervous system" "Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC" "21" "0" "1.014" "1.041" "1.071" "1.061" "1.022" "0.983" "0.972" "1.081" "1.036" "1117.9" "1133.9" "1163.3" "1196.8" "1186.0" "1142.9" "1099.5" "1086.7" "1208.5" "1157.9" "" "" "" "" "" "" "" "" "" "" "1047.5" "938.2" "1080.0" "925.2" "1010.9" "1092.0" "1004.6" "964.9" "1208.5" "1114.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7097595206598813277" "False" "High" "IsMasterProtein" "P09012" "U1 small nuclear ribonucleoprotein A OS=Homo sapiens OX=9606 GN=SNRPA PE=1 SV=3" "0.000" "False" "24.219" "28" "7" "14" "5" "282" "31.3" "9.83" "49.38" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "6626" "ENSG00000077312" "SNRPA" "hsa:6626; P09012" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "2" "0.963" "0.999" "0.920" "0.908" "0.928" "1.004" "0.941" "0.941" "0.912" "3889.9" "3744.3" "3885.8" "3577.3" "3532.3" "3608.0" "3904.8" "3660.6" "3660.2" "3546.1" "" "" "" "" "" "" "" "" "" "" "3644.8" "3098.4" "3607.5" "2765.5" "3010.9" "3447.1" "3568.0" "3250.2" "3660.2" "3414.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7202922108567294127" "False" "High" "IsMasterProtein" "Q8IZP0" "Abl interactor 1 OS=Homo sapiens OX=9606 GN=ABI1 PE=1 SV=4" "0.000" "False" "24.181" "18" "8" "10" "6" "508" "55.0" "7.06" "31.06" "8" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00018, Pf07815" "10006" "ENSG00000136754" "ABI1" "A9Z1Y6; B3KX62; B4DQ58; H7BXI6; hsa:10006; O15147; O76049; O95060; Q5T2R3; Q5T2R4; Q5T2R6; Q5T2R7; Q5T2R9; Q5W070; Q5W072; Q8IZP0; Q8TB63; Q96S81; Q9NXZ9; Q9NYB8" "EGF/EGFR signaling pathway" "RAC1 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway; RAC2 GTPase cycle; RAC3 GTPase cycle; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "8" "2" "0.946" "1.021" "0.882" "0.983" "1.005" "0.887" "0.986" "0.963" "0.957" "1549.0" "1465.2" "1581.8" "1366.4" "1523.2" "1557.3" "1373.8" "1527.8" "1491.7" "1482.4" "" "" "" "" "" "" "" "" "" "" "1451.4" "1212.4" "1468.5" "1056.3" "1298.4" "1487.8" "1255.3" "1356.6" "1491.7" "1427.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3337700356256422645" "False" "High" "IsMasterProtein" "Q86XR2" "Protein Niban 3 OS=Homo sapiens OX=9606 GN=NIBAN3 PE=1 SV=2" "0.000" "False" "24.179" "12" "10" "11" "10" "697" "77.4" "8.63" "31.89" "10" "" "" "" "" "199786" "ENSG00000167483" "NIBAN3" "B4DNU3; B4DVN7; hsa:199786; Q7Z6H6; Q86XR2; Q86XR3; Q86XR4; Q8TEQ3" "" "" "0" "0" "0.977" "0.999" "1.084" "1.056" "1.059" "1.052" "0.966" "0.970" "1.044" "980.6" "958.0" "980.0" "1063.4" "1035.5" "1038.0" "1032.1" "947.7" "951.5" "1023.5" "" "" "" "" "" "" "" "" "" "" "918.8" "792.7" "909.8" "822.1" "882.7" "991.7" "943.0" "841.5" "951.5" "985.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5955155913055998566" "False" "High" "IsMasterProtein" "P28062" "Proteasome subunit beta type-8 OS=Homo sapiens OX=9606 GN=PSMB8 PE=1 SV=3" "0.000" "False" "24.148" "32" "8" "11" "8" "276" "30.3" "7.43" "39.67" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227" "5696" "ENSG00000204264; ENSG00000206298; ENSG00000226201; ENSG00000230034; ENSG00000230669; ENSG00000231631; ENSG00000235715; ENSG00000236443" "PSMB8" "B0UZC0; hsa:5696; P28062; Q29824; Q5JNW6; Q5QNR8; Q96J48" "Proteasome degradation; Immune response to tuberculosis" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Interferon alpha/beta signaling" "62" "0" "1.033" "1.044" "1.044" "1.088" "1.073" "0.971" "1.046" "1.107" "1.055" "1111.3" "1147.6" "1160.6" "1160.2" "1209.0" "1192.6" "1079.0" "1162.9" "1230.1" "1172.4" "" "" "" "" "" "" "" "" "" "" "1041.3" "949.6" "1077.5" "896.9" "1030.5" "1139.4" "985.9" "1032.5" "1230.1" "1128.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5768546020460865093" "False" "High" "IsMasterProtein" "O15160" "DNA-directed RNA polymerases I and III subunit RPAC1 OS=Homo sapiens OX=9606 GN=POLR1C PE=1 SV=1" "0.000" "False" "24.146" "26" "7" "10" "7" "346" "39.2" "5.50" "38.47" "7" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01000, Pf01193" "9533" "ENSG00000171453" "POLR1C" "hsa:9533; O15160; O75395; Q5JTE3" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "15" "0" "0.940" "1.010" "0.961" "0.999" "1.019" "0.990" "1.013" "1.019" "1.025" "1176.4" "1105.7" "1188.6" "1130.4" "1175.3" "1198.5" "1165.2" "1191.8" "1198.9" "1206.1" "" "" "" "" "" "" "" "" "" "" "1102.3" "914.9" "1103.5" "873.9" "1001.8" "1145.0" "1064.7" "1058.2" "1198.9" "1161.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8333902830713908614" "False" "High" "IsMasterProtein" "P05388" "Large ribosomal subunit protein uL10 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1" "0.000" "False" "24.114" "19" "6" "13" "6" "317" "34.3" "5.97" "32.76" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00428, Pf00466, Pf17777" "6175" "ENSG00000089157" "RPLP0" "hsa:6175; P05388; Q3B7A4; Q9BVK4" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.017" "1.135" "1.092" "1.128" "1.176" "1.166" "1.222" "1.162" "1.099" "1234.0" "1254.7" "1400.0" "1348.0" "1391.4" "1450.6" "1438.3" "1507.5" "1434.0" "1355.9" "" "" "" "" "" "" "" "" "" "" "1156.3" "1038.3" "1299.7" "1042.1" "1186.0" "1385.9" "1314.2" "1338.5" "1434.0" "1305.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6899043111177724007" "False" "High" "IsMasterProtein" "Q15208" "Serine/threonine-protein kinase 38 OS=Homo sapiens OX=9606 GN=STK38 PE=1 SV=1" "0.000" "False" "24.111" "18" "9" "9" "9" "465" "54.2" "7.15" "30.04" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433" "11329" "ENSG00000112079" "STK38" "hsa:11329; Q15208; Q503A1" "Interactome of polycomb repressive complex 2 (PRC2)" "RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "3" "0" "1.033" "0.951" "1.181" "1.048" "0.953" "1.080" "0.937" "0.893" "0.989" "914.4" "944.5" "869.5" "1080.3" "958.5" "871.3" "987.5" "856.6" "817.0" "904.6" "" "" "" "" "" "" "" "" "" "" "856.8" "781.6" "807.2" "835.1" "817.0" "832.4" "902.3" "760.6" "817.0" "871.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8595092831186639682" "False" "High" "IsMasterProtein" "Q99961" "Endophilin-A2 OS=Homo sapiens OX=9606 GN=SH3GL1 PE=1 SV=1" "0.000" "False" "24.100" "26" "10" "11" "10" "368" "41.5" "5.43" "34.01" "10" "cell organization and biogenesis;transport;developmental processes;signal transduction" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf03114" "6455" "ENSG00000141985" "SH3GL1" "B4DRA1; E7EVZ4; hsa:6455; M0QZV5; Q99668; Q99961" "Fragile X syndrome" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "6" "0" "1.021" "0.964" "1.028" "1.055" "1.027" "1.008" "1.014" "1.005" "1.036" "884.2" "903.1" "852.2" "909.1" "933.3" "907.7" "890.9" "896.9" "888.7" "915.9" "" "" "" "" "" "" "" "" "" "" "828.5" "747.3" "791.2" "702.8" "795.5" "867.3" "814.0" "796.4" "888.7" "881.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9176436912319366181" "False" "High" "IsMasterProtein" "Q9Y5Q9" "General transcription factor 3C polypeptide 3 OS=Homo sapiens OX=9606 GN=GTF3C3 PE=1 SV=1" "0.000" "False" "24.099" "10" "8" "9" "8" "886" "101.2" "5.07" "29.68" "8" "RNA metabolism OR transcription;other metabolic processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13181" "9330" "ENSG00000119041" "GTF3C3" "hsa:9330; Q4ZG48; Q86XJ8; Q8WX84; Q96B44; Q9H5I8; Q9NT97; Q9Y5Q9" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "3" "0" "0.959" "0.999" "1.004" "0.972" "0.938" "0.967" "0.958" "1.000" "0.973" "557.1" "534.2" "556.4" "559.2" "541.6" "522.6" "538.7" "533.6" "557.1" "541.9" "" "" "" "" "" "" "" "" "" "" "522.0" "442.0" "516.5" "432.3" "461.7" "499.3" "492.2" "473.8" "557.1" "521.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "250780751349012114" "False" "High" "IsMasterProtein" "Cont_Q29443" "Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1" "0.000" "True" "24.084" "14" "9" "10" "9" "704" "77.7" "7.08" "24.60" "9" "stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf00405" "280705" "" "TF" "bta:280705; Q0IIK2; Q29443" "" "" "0" "0" "0.949" "0.939" "0.976" "1.105" "1.096" "1.045" "1.060" "1.042" "0.956" "620.5" "589.1" "582.5" "605.5" "685.3" "679.8" "648.3" "658.0" "646.5" "593.5" "" "" "" "" "" "" "" "" "" "" "581.4" "487.5" "540.8" "468.1" "584.1" "649.5" "592.4" "584.2" "646.5" "571.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3428754804967895147" "False" "High" "IsMasterProtein" "O95989" "Diphosphoinositol polyphosphate phosphohydrolase 1 OS=Homo sapiens OX=9606 GN=NUDT3 PE=1 SV=1" "0.000" "False" "24.064" "35" "5" "9" "5" "172" "19.5" "6.34" "28.43" "5" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00293" "11165" "ENSG00000272325" "NUDT3" "B2R8N4; hsa:11165; O95989" "" "Synthesis of pyrophosphates in the cytosol" "1" "0" "0.969" "0.986" "0.895" "0.943" "1.017" "0.904" "0.952" "0.990" "0.963" "1338.8" "1297.8" "1320.6" "1198.9" "1262.3" "1361.3" "1210.1" "1274.9" "1325.0" "1289.3" "" "" "" "" "" "" "" "" "" "" "1254.5" "1073.9" "1226.0" "926.8" "1075.9" "1300.6" "1105.7" "1132.0" "1325.0" "1241.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6720248987179001386" "False" "High" "IsMasterProtein" "O60313" "Dynamin-like GTPase OPA1, mitochondrial OS=Homo sapiens OX=9606 GN=OPA1 PE=1 SV=3" "0.000" "False" "24.063" "8" "9" "10" "9" "960" "111.6" "7.87" "28.32" "9" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00350, Pf19434" "4976" "ENSG00000198836" "OPA1" "D3DNW4; E5KLJ5; E5KLJ6; E5KLJ7; E5KLK1; E5KLK2; hsa:4976; O60313" "Orexin receptor pathway" "Mitochondrial protein degradation; Regulation of Apoptosis" "3" "0" "0.977" "1.013" "1.078" "1.141" "1.197" "1.171" "1.187" "1.207" "1.141" "726.8" "709.9" "736.0" "783.6" "829.2" "869.8" "851.2" "862.6" "877.3" "829.4" "" "" "" "" "" "" "" "" "" "" "681.0" "587.5" "683.2" "605.8" "706.8" "831.0" "777.8" "765.9" "877.3" "798.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9134922039646345365" "False" "High" "IsMasterProtein" "Q8NBF2" "NHL repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=NHLRC2 PE=1 SV=1" "0.000" "False" "24.054" "12" "8" "9" "8" "726" "79.4" "5.55" "28.59" "8" "" "non-structural extracellular;cytosol;other cell component" "" "Pf01436, Pf13905" "374354" "ENSG00000196865" "NHLRC2" "hsa:374354; Q8N1H1; Q8N5A6; Q8NBF2" "" "Platelet degranulation" "1" "0" "0.945" "0.967" "1.034" "0.934" "0.915" "0.951" "0.926" "0.958" "0.960" "820.2" "774.9" "793.0" "848.1" "765.7" "750.7" "780.2" "759.7" "785.9" "787.2" "" "" "" "" "" "" "" "" "" "" "768.5" "641.2" "736.2" "655.6" "652.7" "717.2" "712.9" "674.5" "785.9" "758.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7763347901800507563" "False" "High" "IsMasterProtein" "Q9HB19" "Pleckstrin homology domain-containing family A member 2 OS=Homo sapiens OX=9606 GN=PLEKHA2 PE=1 SV=3" "0.000" "False" "24.035" "17" "8" "12" "8" "425" "47.2" "8.66" "39.63" "8" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00169" "59339" "ENSG00000169499" "PLEKHA2" "A8K727; hsa:59339; Q9HB19" "" "Synthesis of PIPs at the plasma membrane" "1" "0" "0.960" "1.034" "0.960" "0.990" "0.991" "0.934" "0.972" "0.940" "0.980" "2204.1" "2115.1" "2278.5" "2116.5" "2181.3" "2185.1" "2058.7" "2142.7" "2072.6" "2160.9" "" "" "" "" "" "" "" "" "" "" "2065.2" "1750.2" "2115.3" "1636.1" "1859.3" "2087.6" "1881.1" "1902.5" "2072.6" "2080.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "551881844425109656" "False" "High" "IsMasterProtein" "Q13573" "SNW domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SNW1 PE=1 SV=1" "0.000" "False" "24.012" "17" "8" "12" "8" "536" "61.5" "9.52" "29.28" "8" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf02731" "22938" "ENSG00000100603" "SNW1" "A8K8A9; hsa:22938; Q13483; Q13573; Q32N03; Q5D0D6" "TGF-beta signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Splicing factor NOVA regulated synaptic proteins; Notch signaling pathway" "mRNA Splicing - Major Pathway; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "16" "0" "0.974" "1.000" "0.959" "1.023" "1.044" "1.001" "1.142" "1.062" "1.057" "674.9" "657.3" "674.9" "647.4" "690.6" "704.3" "675.8" "770.6" "716.7" "713.6" "" "" "" "" "" "" "" "" "" "" "632.4" "543.9" "626.6" "500.5" "588.7" "672.9" "617.5" "684.2" "716.7" "687.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4048246386295190521" "False" "High" "IsMasterProtein" "Q9Y6E0" "Serine/threonine-protein kinase 24 OS=Homo sapiens OX=9606 GN=STK24 PE=1 SV=1" "0.000" "False" "23.979" "18" "8" "10" "3" "443" "49.3" "5.69" "31.97" "8" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "8428" "ENSG00000102572" "STK24" "hsa:8428; O14840; Q5JV92; Q9Y6E0" "" "Apoptotic cleavage of cellular proteins" "2" "0" "1.030" "1.079" "0.958" "1.057" "1.115" "1.034" "1.047" "1.072" "1.070" "564.3" "581.4" "608.9" "540.7" "596.2" "629.1" "583.2" "590.7" "604.8" "604.0" "" "" "" "" "" "" "" "" "" "" "528.7" "481.1" "565.3" "418.0" "508.2" "601.1" "532.9" "524.5" "604.8" "581.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8981469479003528624" "False" "High" "IsMasterProtein" "Q9BZE1" "Large ribosomal subunit protein mL37 OS=Homo sapiens OX=9606 GN=MRPL37 PE=1 SV=2" "0.000" "False" "23.973" "22" "10" "13" "10" "423" "48.1" "8.59" "29.05" "10" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf07147" "51253" "ENSG00000116221" "MRPL37" "hsa:51253; Q96Q67; Q9BWR1; Q9BZE1; Q9P0P3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.998" "1.047" "1.025" "1.067" "1.069" "0.994" "1.041" "1.002" "1.040" "1228.5" "1226.2" "1286.6" "1259.7" "1310.5" "1312.7" "1221.2" "1278.9" "1230.8" "1277.5" "" "" "" "" "" "" "" "" "" "" "1151.1" "1014.7" "1194.5" "973.8" "1117.0" "1254.1" "1115.9" "1135.6" "1230.8" "1230.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6701833234650983688" "False" "High" "IsMasterProtein" "O43865" "S-adenosylhomocysteine hydrolase-like protein 1 OS=Homo sapiens OX=9606 GN=AHCYL1 PE=1 SV=2" "0.000" "False" "23.880" "14" "9" "15" "4" "530" "58.9" "6.89" "48.55" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00670, Pf05221" "10768" "ENSG00000168710" "AHCYL1" "B4E168; hsa:10768; O43865; Q2TAJ6; Q502W8; Q5VSM0; Q6P171; Q96PK4; Q9UG84" "Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways" "Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Regulation of insulin secretion; VEGFR2 mediated cell proliferation; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation" "12" "2" "0.984" "1.033" "0.964" "0.990" "0.997" "0.928" "0.928" "0.931" "0.963" "995.6" "979.9" "1028.7" "959.4" "985.4" "993.0" "924.3" "924.3" "927.0" "958.8" "" "" "" "" "" "" "" "" "" "" "932.9" "810.8" "955.0" "741.7" "839.9" "948.7" "844.6" "820.7" "927.0" "923.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4847329680640326989" "False" "High" "IsMasterProtein" "Q8NDI1" "EH domain-binding protein 1 OS=Homo sapiens OX=9606 GN=EHBP1 PE=1 SV=3" "0.000" "False" "23.877" "7" "9" "10" "9" "1231" "139.9" "5.35" "27.37" "9" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "" "Pf00307, Pf10358, Pf12130" "23301" "ENSG00000115504" "EHBP1" "hsa:23301; O94977; Q53TG7; Q53TV6; Q580X2; Q6NX72; Q6PIT3; Q6QNV2; Q8NDI1; Q9NWI9" "Ciliary landscape" "" "1" "0" "0.996" "1.020" "1.018" "1.011" "1.026" "1.052" "1.030" "1.009" "1.048" "767.2" "764.2" "782.9" "781.1" "775.6" "787.0" "807.4" "790.3" "774.4" "804.4" "" "" "" "" "" "" "" "" "" "" "718.9" "632.4" "726.9" "603.9" "661.1" "751.9" "737.8" "701.7" "774.4" "774.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400550207963658767" "False" "High" "IsMasterProtein" "Q8WWY3" "U4/U6 small nuclear ribonucleoprotein Prp31 OS=Homo sapiens OX=9606 GN=PRPF31 PE=1 SV=2" "0.000" "False" "23.875" "14" "7" "11" "7" "499" "55.4" "5.78" "34.51" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01798, Pf09785" "26121" "ENSG00000105618; ENSG00000274144; ENSG00000274651; ENSG00000274894; ENSG00000275117; ENSG00000275885; ENSG00000276421; ENSG00000277154; ENSG00000277707; ENSG00000277953" "PRPF31" "E7ESA8; F1T0A4; F1T0A5; hsa:26121; Q17RB4; Q8N7F9; Q8WWY3; Q9H271; Q9Y439" "" "mRNA Splicing - Major Pathway" "1" "0" "1.010" "1.041" "1.000" "1.050" "1.096" "1.064" "1.082" "1.097" "1.070" "2114.8" "2135.0" "2202.0" "2114.9" "2220.7" "2317.8" "2250.2" "2288.8" "2320.0" "2263.2" "" "" "" "" "" "" "" "" "" "" "1981.6" "1766.7" "2044.2" "1634.9" "1892.8" "2214.4" "2056.1" "2032.3" "2320.0" "2179.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1849398190907063362" "False" "High" "IsMasterProtein" "P35813" "Protein phosphatase 1A OS=Homo sapiens OX=9606 GN=PPM1A PE=1 SV=1" "0.000" "False" "23.861" "23" "8" "8" "7" "382" "42.4" "5.36" "28.28" "8" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf00481, Pf07830" "5494" "ENSG00000100614" "PPM1A" "B5BU11; hsa:5494; J3KNM0; O75551; P35813" "TGF-beta signaling pathway; MAPK signaling pathway" "Downregulation of SMAD2/3:SMAD4 transcriptional activity; Energy dependent regulation of mTOR by LKB1-AMPK" "4" "0" "0.962" "0.981" "0.988" "0.975" "1.019" "0.964" "0.981" "0.971" "0.989" "1326.9" "1276.9" "1301.9" "1310.9" "1294.3" "1351.6" "1279.1" "1302.0" "1288.3" "1312.9" "" "" "" "" "" "" "" "" "" "" "1243.3" "1056.6" "1208.6" "1013.4" "1103.2" "1291.3" "1168.8" "1156.0" "1288.3" "1264.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4533705047032389806" "False" "High" "IsMasterProtein" "P62241" "Small ribosomal subunit protein eS8 OS=Homo sapiens OX=9606 GN=RPS8 PE=1 SV=2" "0.000" "False" "23.856" "39" "7" "15" "7" "208" "24.2" "10.32" "50.73" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01201" "6202" "ENSG00000142937" "RPS8" "hsa:6202; P09058; P62241; Q6IRL7" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.044" "1.058" "1.097" "1.044" "0.973" "1.034" "1.037" "1.026" "1.021" "1320.6" "1378.2" "1397.1" "1449.4" "1379.3" "1285.6" "1365.3" "1369.0" "1355.4" "1348.1" "" "" "" "" "" "" "" "" "" "" "1237.4" "1140.5" "1297.0" "1120.4" "1175.7" "1228.3" "1247.5" "1215.5" "1355.4" "1298.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7476906646827946246" "False" "High" "IsMasterProtein" "Q13315" "Serine-protein kinase ATM OS=Homo sapiens OX=9606 GN=ATM PE=1 SV=4" "0.000" "False" "23.835" "3" "11" "13" "11" "3056" "350.5" "6.81" "33.88" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf11640" "472" "ENSG00000149311" "ATM" "B2RNX5; hsa:472; O15429; Q12758; Q13315; Q16551; Q93007; Q9NP02; Q9UCX7" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Homologous recombination; Glioblastoma signaling pathways; ATM signaling pathway; DDX1 as a regulatory component of the Drosha microprocessor; Ovarian infertility; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; ATM signaling in development and disease ; DNA IR-double strand breaks and cellular response via ATM; miRNA regulation of p53 pathway in prostate cancer; DNA IR-damage and cellular response via ATR; Breast cancer pathway; G1 to S cell cycle control; Joubert syndrome; Male infertility; DNA repair pathways, full network; Pleural mesothelioma; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome; Primary ovarian insufficiency; DNA damage response; DNA damage response (only ATM dependent)" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; TP53 Regulates Transcription of DNA Repair Genes; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Holliday Junction Intermediates; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Degradation; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of TP53 Activity through Methylation; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Sensing of DNA Double Strand Breaks; Pexophagy" "54" "0" "0.975" "1.003" "1.023" "1.007" "1.042" "0.934" "0.905" "0.979" "1.022" "1239.9" "1209.2" "1243.4" "1268.7" "1248.1" "1292.5" "1158.5" "1121.8" "1214.1" "1267.1" "" "" "" "" "" "" "" "" "" "" "1161.8" "1000.6" "1154.3" "980.8" "1063.9" "1234.8" "1058.6" "996.1" "1214.1" "1220.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8244788051015200479" "False" "High" "IsMasterProtein" "O43447" "Peptidyl-prolyl cis-trans isomerase H OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=1" "0.000" "False" "23.808" "34" "7" "18" "6" "177" "19.2" "8.07" "33.69" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00160" "10465" "ENSG00000171960" "PPIH" "A6NNE7; hsa:10465; O43447" "" "mRNA Splicing - Major Pathway; SARS-CoV-1 activates/modulates innate immune responses" "2" "0" "1.003" "0.994" "1.016" "1.032" "0.989" "0.988" "1.030" "1.023" "0.997" "1366.1" "1370.0" "1357.9" "1387.9" "1410.2" "1351.3" "1349.7" "1407.6" "1397.5" "1362.3" "" "" "" "" "" "" "" "" "" "" "1280.0" "1133.7" "1260.6" "1072.9" "1202.0" "1291.1" "1233.3" "1249.8" "1397.5" "1311.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8668239743978999828" "False" "High" "IsMasterProtein" "Q9NSI2" "Ribosome biogenesis protein SLX9 homolog OS=Homo sapiens OX=9606 GN=SLX9 PE=1 SV=2" "0.000" "False" "23.793" "33" "7" "10" "7" "230" "25.4" "11.08" "34.85" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf15341" "85395" "ENSG00000160256" "SLX9" "hsa:85395; Q9NSI2" "" "" "0" "0" "1.052" "1.033" "1.192" "1.131" "1.081" "1.078" "1.057" "1.054" "1.052" "285.1" "300.0" "294.4" "339.8" "322.3" "308.2" "307.3" "301.4" "300.6" "300.0" "" "" "" "" "" "" "" "" "" "" "267.1" "248.3" "273.3" "262.7" "274.7" "294.5" "280.8" "267.6" "300.6" "288.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4622690060897357887" "False" "High" "IsMasterProtein" "Q9UII2" "ATPase inhibitor, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5IF1 PE=1 SV=1" "0.000" "False" "23.774" "32" "6" "20" "6" "106" "12.2" "9.35" "57.24" "6" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf04568" "93974" "ENSG00000130770; ENSG00000285390" "ATP5IF1" "hsa:93974; Q5JXL8; Q6IAQ7; Q9BSL9; Q9UII2" "Electron transport chain: OXPHOS system in mitochondria" "" "1" "0" "1.052" "1.006" "0.949" "1.003" "0.967" "0.945" "0.886" "0.883" "0.922" "1172.0" "1232.5" "1179.4" "1111.8" "1175.1" "1133.2" "1107.4" "1038.4" "1034.7" "1080.9" "" "" "" "" "" "" "" "" "" "" "1098.1" "1019.9" "1094.9" "859.5" "1001.6" "1082.7" "1011.8" "922.0" "1034.7" "1040.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2375108519350628678" "False" "High" "IsMasterProtein" "Q13547" "Histone deacetylase 1 OS=Homo sapiens OX=9606 GN=HDAC1 PE=1 SV=1" "0.000" "False" "23.769" "14" "8" "14" "5" "482" "55.1" "5.48" "46.19" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850" "3065" "ENSG00000116478" "HDAC1" "hsa:3065; Q13547; Q92534" "Androgen receptor signaling pathway; Energy metabolism; Cell cycle; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Retinoblastoma gene in cancer; Notch signaling; Apoptosis-related network due to altered Notch3 in ovarian cancer; Initiation of transcription and translation elongation at the HIV-1 LTR; MECP2 and associated Rett syndrome; IL6 signaling pathway; TGF-beta signaling pathway; Valproic acid pathway; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Rett syndrome; Effect of progerin on genes involved in progeria; Ciliary landscape; Transcription co-factors SKI and SKIL protein partners; Overlap between signal transduction pathways contributing to LMNA laminopathies; Opioid receptor pathways; 15q11q13 copy number variation; Notch signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "Potential therapeutics for SARS; Estrogen-dependent gene expression; SUMOylation of chromatin organization proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Formation of the beta-catenin:TCF transactivating complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of PTEN gene transcription; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; MECP2 regulates transcription of neuronal ligands; Factors involved in megakaryocyte development and platelet production; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RNA Polymerase I Transcription Initiation; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of MECP2 expression and activity; STAT3 nuclear events downstream of ALK signaling; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; G1/S-Specific Transcription; Regulation of TP53 Activity through Acetylation; Transcription of E2F targets under negative control by DREAM complex; Nuclear events stimulated by ALK signaling in cancer; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; MECP2 regulates neuronal receptors and channels; Repression of WNT target genes; Loss of MECP2 binding ability to 5mC-DNA" "56" "4" "0.912" "1.039" "0.864" "0.926" "0.912" "0.949" "0.946" "0.929" "0.965" "3004.6" "2740.1" "3121.9" "2595.3" "2781.9" "2740.4" "2850.9" "2840.9" "2791.2" "2898.3" "" "" "" "" "" "" "" "" "" "" "2815.3" "2267.4" "2898.3" "2006.3" "2371.2" "2618.2" "2605.0" "2522.4" "2791.2" "2790.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7500811780682688662" "False" "High" "IsMasterProtein" "Q8N8S7" "Protein enabled homolog OS=Homo sapiens OX=9606 GN=ENAH PE=1 SV=2" "0.000" "False" "23.766" "12" "8" "15" "7" "591" "66.5" "6.93" "45.40" "8" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "55740" "ENSG00000154380" "ENAH" "D0PQI2; hsa:55740; Q502W5; Q5T5M7; Q5VTQ9; Q5VTR0; Q8N8S7; Q9NVF3; Q9UFB8" "Regulation of actin cytoskeleton" "Generation of second messenger molecules; Signaling by ROBO receptors" "3" "1" "0.936" "0.975" "0.892" "0.965" "0.975" "0.960" "0.956" "0.953" "0.967" "2240.7" "2096.2" "2184.6" "1998.6" "2162.7" "2184.0" "2150.7" "2143.1" "2134.3" "2167.9" "" "" "" "" "" "" "" "" "" "" "2099.5" "1734.6" "2028.2" "1545.0" "1843.4" "2086.6" "1965.2" "1902.8" "2134.3" "2087.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1037912225033679960" "False" "High" "IsMasterProtein" "P47756" "F-actin-capping protein subunit beta OS=Homo sapiens OX=9606 GN=CAPZB PE=1 SV=5" "0.000" "False" "23.765" "25" "7" "17" "7" "272" "30.6" "6.00" "44.79" "7" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01115" "832" "ENSG00000077549" "CAPZB" "hsa:832; P47756; Q32Q68; Q5U0L4; Q8TB49; Q9NUC4" "VEGFA-VEGFR2 signaling" "MHC class II antigen presentation; Sensory processing of sound by inner hair cells of the cochlea; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; RHOD GTPase cycle; RHOF GTPase cycle; Factors involved in megakaryocyte development and platelet production" "9" "0" "0.852" "0.995" "0.856" "0.789" "0.802" "0.813" "0.815" "0.836" "0.793" "2273.0" "1935.5" "2262.0" "1945.4" "1793.4" "1823.8" "1847.4" "1851.4" "1899.8" "1803.5" "" "" "" "" "" "" "" "" "" "" "2129.8" "1601.6" "2099.9" "1503.9" "1528.7" "1742.5" "1688.0" "1643.9" "1899.8" "1736.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4415570283207223737" "False" "High" "IsMasterProtein" "Q08257" "Quinone oxidoreductase OS=Homo sapiens OX=9606 GN=CRYZ PE=1 SV=1" "0.000" "False" "23.713" "21" "7" "14" "7" "329" "35.2" "8.44" "43.70" "7" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf08240, Pf13602" "1429" "ENSG00000116791" "CRYZ" "A6NN60; D3DQ76; hsa:1429; Q08257; Q53FT0; Q59EU7; Q5HYE7; Q6NSK9" "" "" "0" "0" "0.977" "1.036" "1.005" "1.065" "0.986" "0.961" "1.004" "1.008" "0.985" "1261.3" "1231.8" "1307.1" "1267.9" "1343.7" "1243.2" "1211.8" "1266.2" "1271.5" "1242.1" "" "" "" "" "" "" "" "" "" "" "1181.8" "1019.3" "1213.5" "980.2" "1145.3" "1187.8" "1107.2" "1124.2" "1271.5" "1196.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8624689202228352756" "False" "High" "IsMasterProtein" "Q8IWJ2" "GRIP and coiled-coil domain-containing protein 2 OS=Homo sapiens OX=9606 GN=GCC2 PE=1 SV=4" "0.000" "False" "23.711" "5" "9" "10" "7" "1684" "195.8" "5.14" "24.71" "9" "cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf01465, Pf16704" "9648" "ENSG00000135968" "GCC2" "A6H8X8; hsa:9648; O15045; Q4ZG46; Q8IWJ2; Q8TDH3; Q9H2G8" "Deregulation of Rab and Rab effector genes in bladder cancer" "Retrograde transport at the Trans-Golgi-Network; Signaling by ALK fusions and activated point mutants" "3" "1" "0.996" "1.001" "0.965" "1.037" "1.015" "0.919" "0.940" "0.934" "0.966" "586.2" "583.8" "586.8" "565.8" "607.7" "594.8" "538.6" "550.9" "547.6" "566.5" "" "" "" "" "" "" "" "" "" "" "549.3" "483.1" "544.8" "437.4" "518.0" "568.2" "492.1" "489.1" "547.6" "545.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5057410005729893010" "False" "High" "IsMasterProtein" "Q7Z4Q2" "HEAT repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=HEATR3 PE=1 SV=2" "0.000" "False" "23.705" "12" "8" "10" "8" "680" "74.5" "5.11" "27.03" "8" "transport;other biological processes" "" "other molecular function" "Pf13513" "55027" "ENSG00000155393" "HEATR3" "A8K1N4; hsa:55027; Q7Z4Q2; Q8N525; Q8WV56; Q96CC9; Q9NWN7" "" "" "0" "0" "0.985" "1.056" "1.018" "1.027" "0.977" "0.971" "0.974" "0.963" "1.004" "582.7" "573.7" "615.4" "592.9" "598.6" "569.1" "565.7" "567.5" "561.4" "585.2" "" "" "" "" "" "" "" "" "" "" "546.0" "474.8" "571.4" "458.4" "510.2" "543.7" "516.9" "503.9" "561.4" "563.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3625950205882740020" "False" "High" "IsMasterProtein" "Q9NWQ8" "Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 OS=Homo sapiens OX=9606 GN=PAG1 PE=1 SV=2" "0.000" "False" "23.683" "21" "7" "7" "7" "432" "47.0" "4.65" "25.05" "7" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf15347" "55824" "ENSG00000076641" "PAG1" "A8K1A3; hsa:55824; Q2M1Z9; Q5BKU4; Q9NWQ8; Q9NYK0" "" "Phosphorylation of CD3 and TCR zeta chains; GAB1 signalosome" "2" "0" "1.043" "1.004" "1.011" "1.050" "0.968" "1.127" "1.156" "1.139" "1.069" "730.9" "762.1" "733.8" "738.7" "767.7" "707.6" "823.4" "844.6" "832.2" "781.4" "" "" "" "" "" "" "" "" "" "" "684.9" "630.6" "681.2" "571.0" "654.4" "676.0" "752.4" "749.9" "832.2" "752.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8106811875095759613" "False" "High" "IsMasterProtein" "P06454" "Prothymosin alpha OS=Homo sapiens OX=9606 GN=PTMA PE=1 SV=2" "0.000" "False" "23.672" "23" "5" "23" "5" "111" "12.2" "3.78" "84.69" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf03247" "5757" "ENSG00000187514" "PTMA" "hsa:5757; P06454; Q15249; Q15592" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.121" "0.931" "0.959" "0.890" "0.851" "0.732" "0.730" "0.712" "0.841" "6344.5" "7109.9" "5907.2" "6084.2" "5645.5" "5396.3" "4644.0" "4630.0" "4515.9" "5337.5" "" "" "" "" "" "" "" "" "" "" "5944.8" "5883.3" "5484.1" "4703.4" "4812.1" "5155.6" "4243.3" "4111.0" "4515.9" "5139.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4683582367495080514" "False" "High" "IsMasterProtein" "Q6IA86" "Elongator complex protein 2 OS=Homo sapiens OX=9606 GN=ELP2 PE=1 SV=2" "0.000" "False" "23.655" "11" "8" "10" "8" "826" "92.4" "5.96" "27.80" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "55250" "ENSG00000134759" "ELP2" "A8KAI6; B4DTG0; B4DXP0; E7EP23; E9PCX0; Q53GZ0; Q687Y8; Q6IA86; Q8N5C2; Q96GV4; Q96PI7; Q9H9N0; Q9NV81" "" "HATs acetylate histones" "1" "0" "0.997" "1.040" "1.001" "1.019" "1.023" "0.991" "0.961" "0.973" "0.991" "539.1" "537.4" "560.5" "539.5" "549.5" "551.2" "534.4" "518.3" "524.8" "534.1" "" "" "" "" "" "" "" "" "" "" "505.1" "444.7" "520.3" "417.0" "468.4" "526.7" "488.3" "460.2" "524.8" "514.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562653879591220854" "False" "High" "IsMasterProtein" "P09488" "Glutathione S-transferase Mu 1 OS=Homo sapiens OX=9606 GN=GSTM1 PE=1 SV=3" "0.000" "False" "23.643" "25" "7" "14" "7" "218" "25.7" "6.70" "44.10" "7" "other metabolic processes;stress response" "cytosol;other cell component" "other molecular function" "Pf00043, Pf02798" "2944" "ENSG00000134184" "GSTM1" "hsa:2944; P09488; Q5GHG0; Q6FH88; Q8TC98; Q9UC96" "Glutathione metabolism; Nuclear receptors meta-pathway; NRF2 pathway; Benzene metabolism; Estrogen metabolism; Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II" "Paracetamol ADME; Glutathione conjugation; Azathioprine ADME" "10" "0" "0.896" "0.965" "0.860" "0.898" "0.962" "0.855" "0.947" "0.889" "0.937" "2769.3" "2480.5" "2671.2" "2380.3" "2485.5" "2665.3" "2368.5" "2622.4" "2461.0" "2594.5" "" "" "" "" "" "" "" "" "" "" "2594.8" "2052.6" "2479.9" "1840.1" "2118.6" "2546.4" "2164.2" "2328.4" "2461.0" "2498.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6100821946699504428" "False" "High" "IsMasterProtein" "Q5QNW6" "Histone H2B type 2-F OS=Homo sapiens OX=9606 GN=H2BC18 PE=1 SV=3" "0.000" "False" "23.625" "52" "7" "24" "1" "126" "13.9" "10.32" "73.28" "7" "" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "440689" "ENSG00000203814" "H2BC18" "A8K0U9; B4DLA9; hsa:440689; Q5QNW6" "" "HCMV Late Events; HCMV Early Events; Ub-specific processing proteases; HDACs deacetylate histones; HATs acetylate histones" "5" "0" "0.878" "1.177" "0.637" "0.908" "1.077" "0.773" "0.943" "1.108" "0.972" "476.6" "418.4" "560.9" "303.5" "433.0" "513.6" "368.6" "449.6" "528.2" "463.5" "" "" "" "" "" "" "" "" "" "" "446.6" "346.2" "520.8" "234.6" "369.1" "490.7" "336.8" "399.2" "528.2" "446.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "896567990825277729" "False" "High" "IsMasterProtein" "O94925" "Glutaminase kidney isoform, mitochondrial OS=Homo sapiens OX=9606 GN=GLS PE=1 SV=1" "0.000" "False" "23.622" "12" "7" "10" "7" "669" "73.4" "7.77" "36.04" "7" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf04960, Pf12796, Pf17959" "2744" "ENSG00000115419" "GLS" "hsa:2744; O94925; Q9UL05; Q9UL06; Q9UL07; Q9UN40" "Amino acid metabolism; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells; Cell lineage map for neuronal differentiation" "Glutamate Neurotransmitter Release Cycle; TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism" "8" "0" "1.079" "1.025" "1.087" "1.108" "1.137" "1.056" "1.012" "1.071" "1.154" "425.3" "458.8" "435.9" "462.3" "471.3" "483.7" "449.2" "430.5" "455.5" "490.9" "" "" "" "" "" "" "" "" "" "" "398.5" "379.7" "404.7" "357.4" "401.8" "462.2" "410.4" "382.2" "455.5" "472.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8303204193391828869" "False" "High" "IsMasterProtein" "Q8WUI4" "Histone deacetylase 7 OS=Homo sapiens OX=9606 GN=HDAC7 PE=1 SV=2" "0.000" "False" "23.611" "8" "8" "10" "8" "952" "102.9" "7.58" "28.98" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00850" "51564" "ENSG00000061273" "HDAC7" "B3KY08; B4DWI0; B4E0Q5; hsa:51564; Q6P1W9; Q6W9G7; Q7Z4K2; Q7Z5I1; Q8WUI4; Q96K01; Q9BR73; Q9H7L0; Q9NW41; Q9NWA9; Q9NYK9; Q9UFU7" "MicroRNAs in cardiomyocyte hypertrophy; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Gastrin signaling pathway" "SUMOylation of DNA damage response and repair proteins; Regulation of PTEN gene transcription; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway" "13" "0" "1.027" "1.013" "1.024" "1.025" "0.999" "0.974" "0.981" "0.961" "0.980" "654.9" "672.7" "663.2" "670.6" "671.0" "654.0" "637.7" "642.4" "629.1" "641.7" "" "" "" "" "" "" "" "" "" "" "613.6" "556.6" "615.7" "518.4" "571.9" "624.9" "582.6" "570.4" "629.1" "617.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4135876604710417259" "False" "High" "IsMasterProtein" "P49593" "Protein phosphatase 1F OS=Homo sapiens OX=9606 GN=PPM1F PE=1 SV=3" "0.000" "False" "23.599" "21" "7" "10" "7" "454" "49.8" "5.10" "35.44" "7" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00481" "9647" "ENSG00000100034" "PPM1F" "A8K6G3; B7Z2C3; hsa:9647; P49593; Q96PM2" "" "Negative regulation of NMDA receptor-mediated neuronal transmission" "1" "0" "0.931" "1.017" "1.076" "1.083" "1.053" "1.081" "1.031" "1.071" "1.055" "356.7" "331.9" "362.6" "383.7" "386.4" "375.5" "385.5" "367.7" "382.2" "376.2" "" "" "" "" "" "" "" "" "" "" "334.2" "274.7" "336.6" "296.6" "329.3" "358.7" "352.2" "326.5" "382.2" "362.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3039044237151127382" "False" "High" "IsMasterProtein" "P61163" "Alpha-centractin OS=Homo sapiens OX=9606 GN=ACTR1A PE=1 SV=1" "0.000" "False" "23.591" "24" "7" "10" "4" "376" "42.6" "6.64" "35.89" "7" "transport" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00022" "10121" "ENSG00000138107" "ACTR1A" "B2R6B0; hsa:10121; P42024; P61163" "HDAC6 interactions in the central nervous system" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "12" "2" "0.996" "0.979" "0.998" "1.001" "0.987" "0.971" "0.990" "0.977" "0.986" "972.7" "968.5" "952.5" "970.9" "973.9" "960.2" "944.9" "963.2" "949.8" "959.2" "" "" "" "" "" "" "" "" "" "" "911.4" "801.4" "884.3" "750.6" "830.1" "917.4" "863.4" "855.2" "949.8" "923.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7316364973511523624" "False" "High" "IsMasterProtein" "Q8IYI6" "Exocyst complex component 8 OS=Homo sapiens OX=9606 GN=EXOC8 PE=1 SV=2" "0.000" "False" "23.581" "13" "9" "10" "9" "725" "81.7" "5.49" "33.34" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf08700, Pf16528" "149371" "ENSG00000116903" "EXOC8" "B3KU33; hsa:149371; Q5TE82; Q8IYI6" "RalA downstream regulated genes; Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "5" "0" "0.990" "0.949" "0.976" "1.005" "0.999" "0.970" "0.917" "0.995" "0.953" "1163.1" "1151.5" "1103.5" "1135.5" "1169.2" "1161.6" "1128.5" "1066.3" "1157.1" "1108.6" "" "" "" "" "" "" "" "" "" "" "1089.8" "952.8" "1024.4" "877.8" "996.6" "1109.8" "1031.1" "946.8" "1157.1" "1067.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5278147799990617038" "False" "High" "IsMasterProtein" "P78318" "Immunoglobulin-binding protein 1 OS=Homo sapiens OX=9606 GN=IGBP1 PE=1 SV=1" "0.000" "False" "23.567" "25" "7" "11" "7" "339" "39.2" "5.38" "34.84" "7" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf04177" "3476" "ENSG00000089289" "IGBP1" "P78318; Q8TAB2" "16p11.2 proximal deletion syndrome" "" "1" "0" "1.078" "0.991" "1.249" "1.124" "1.161" "1.033" "1.065" "1.030" "1.089" "843.1" "908.8" "835.1" "1052.8" "947.3" "978.8" "871.2" "898.1" "868.7" "918.2" "" "" "" "" "" "" "" "" "" "" "790.0" "752.0" "775.3" "813.8" "807.4" "935.1" "796.1" "797.4" "868.7" "884.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7644336301377244123" "False" "High" "IsMasterProtein" "Q8IZ83" "Aldehyde dehydrogenase family 16 member A1 OS=Homo sapiens OX=9606 GN=ALDH16A1 PE=1 SV=2" "0.000" "False" "23.541" "11" "7" "11" "7" "802" "85.1" "6.79" "38.32" "7" "" "" "other molecular function" "Pf00171" "126133" "ENSG00000161618" "ALDH16A1" "B4DLQ1; C9JBH6; hsa:126133; Q86YF0; Q8IYL4; Q8IZ83; Q8TEI8" "" "" "0" "0" "0.973" "0.986" "0.971" "0.945" "0.960" "0.899" "0.989" "0.951" "0.987" "1446.7" "1407.2" "1426.6" "1405.5" "1366.9" "1389.0" "1300.8" "1431.4" "1376.1" "1427.7" "" "" "" "" "" "" "" "" "" "" "1355.6" "1164.4" "1324.4" "1086.5" "1165.1" "1327.0" "1188.6" "1270.9" "1376.1" "1374.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3912553749902594293" "False" "High" "IsMasterProtein" "P15880" "Small ribosomal subunit protein uS5 OS=Homo sapiens OX=9606 GN=RPS2 PE=1 SV=2" "0.000" "False" "23.530" "29" "9" "12" "9" "293" "31.3" "10.24" "34.16" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00333, Pf03719" "6187" "ENSG00000140988; ENSG00000291931" "RPS2" "B2R5G0; D3DU82; hsa:6187; P15880; Q3MIB1" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; RMTs methylate histone arginines; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Protein methylation; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "22" "0" "1.020" "1.070" "1.047" "1.046" "1.047" "1.159" "1.126" "1.107" "1.064" "1703.5" "1737.4" "1823.3" "1783.9" "1781.4" "1782.7" "1973.6" "1917.5" "1885.7" "1811.7" "" "" "" "" "" "" "" "" "" "" "1596.2" "1437.7" "1692.7" "1379.1" "1518.5" "1703.2" "1803.4" "1702.5" "1885.7" "1744.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4009101809611603487" "False" "High" "IsMasterProtein" "Q9NUW8" "Tyrosyl-DNA phosphodiesterase 1 OS=Homo sapiens OX=9606 GN=TDP1 PE=1 SV=2" "0.000" "False" "23.527" "12" "7" "8" "7" "608" "68.4" "7.65" "24.57" "7" "DNA metabolism;other metabolic processes;stress response" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06087" "55775" "ENSG00000042088" "TDP1" "hsa:55775; Q2HXX4; Q86TV8; Q96BK7; Q9NUW8; Q9NZM7; Q9NZM8" "" "Nonhomologous End-Joining (NHEJ)" "1" "0" "0.994" "0.966" "0.979" "1.000" "1.029" "0.979" "1.009" "0.957" "0.973" "950.5" "945.2" "918.4" "930.3" "950.9" "978.6" "931.0" "959.2" "909.4" "924.6" "" "" "" "" "" "" "" "" "" "" "890.7" "782.2" "852.6" "719.2" "810.5" "934.9" "850.7" "851.7" "909.4" "890.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-852377223734167343" "False" "High" "IsMasterProtein" "Q4G176" "Malonate--CoA ligase ACSF3, mitochondrial OS=Homo sapiens OX=9606 GN=ACSF3 PE=1 SV=3" "0.000" "False" "23.515" "14" "9" "10" "9" "576" "64.1" "8.37" "29.85" "9" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00501, Pf13193" "197322" "ENSG00000176715" "ACSF3" "A8K4J8; C9JQL6; hsa:197322; Q4G176; Q6INA0; Q8N2F7" "" "Synthesis of very long-chain fatty acyl-CoAs" "1" "0" "0.992" "1.032" "1.015" "0.993" "1.009" "1.012" "0.983" "0.954" "0.984" "1331.5" "1321.4" "1374.3" "1350.8" "1322.0" "1343.9" "1347.7" "1308.3" "1270.2" "1310.4" "" "" "" "" "" "" "" "" "" "" "1247.6" "1093.4" "1275.8" "1044.3" "1126.8" "1284.0" "1231.4" "1161.7" "1270.2" "1261.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8706245126759521959" "False" "High" "IsMasterProtein" "Q9BRP4" "Proteasomal ATPase-associated factor 1 OS=Homo sapiens OX=9606 GN=PAAF1 PE=1 SV=2" "0.000" "False" "23.506" "20" "7" "8" "7" "392" "42.2" "6.32" "26.32" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf00400" "80227" "ENSG00000175575" "PAAF1" "A6NDR5; B4DPB0; B7ZAS9; hsa:80227; Q4G165; Q53HS9; Q7Z500; Q8TBU6; Q9BRP4; Q9HAB6" "" "" "0" "0" "1.170" "1.057" "1.115" "1.109" "1.148" "1.104" "0.979" "1.072" "1.058" "380.8" "445.4" "402.5" "424.5" "422.5" "437.2" "420.5" "372.8" "408.1" "402.8" "" "" "" "" "" "" "" "" "" "" "356.8" "368.5" "373.7" "328.2" "360.1" "417.7" "384.2" "331.0" "408.1" "387.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7547854547274614235" "False" "High" "IsMasterProtein" "Q66K74" "Microtubule-associated protein 1S OS=Homo sapiens OX=9606 GN=MAP1S PE=1 SV=2" "0.000" "False" "23.505" "8" "8" "11" "8" "1059" "112.1" "7.30" "32.50" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "" "55201" "ENSG00000130479" "MAP1S" "B4DH53; hsa:55201; Q27QB1; Q66K74; Q6NXF1; Q8N3L8; Q8N3W5; Q8NI88; Q96H94; Q96IT4; Q96SP8; Q9BRC6; Q9H928; Q9NVK7" "" "" "0" "0" "0.970" "0.957" "1.004" "0.976" "0.940" "1.004" "0.946" "0.921" "0.962" "968.9" "939.4" "927.4" "973.1" "946.0" "911.3" "972.9" "916.8" "892.3" "932.2" "" "" "" "" "" "" "" "" "" "" "907.9" "777.4" "861.0" "752.2" "806.3" "870.6" "889.0" "814.0" "892.3" "897.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6610589870849209696" "False" "High" "IsMasterProtein" "Q9NZ63" "Splicing factor C9orf78 OS=Homo sapiens OX=9606 GN=C9orf78 PE=1 SV=1" "0.000" "False" "23.479" "26" "8" "12" "8" "289" "33.7" "6.74" "35.79" "8" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf07052" "51759" "ENSG00000136819" "C9orf78" "B3KPX8; Q8WVU6; Q9NT39; Q9NZ63" "" "mRNA Splicing - Major Pathway" "1" "0" "1.074" "0.930" "0.911" "1.024" "1.003" "1.004" "1.049" "1.015" "0.991" "890.4" "956.0" "828.5" "811.2" "912.0" "893.1" "894.0" "934.0" "903.8" "882.7" "" "" "" "" "" "" "" "" "" "" "834.3" "791.1" "769.1" "627.1" "777.4" "853.3" "816.9" "829.3" "903.8" "849.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2036911108115043510" "False" "High" "IsMasterProtein" "Q96F86" "Enhancer of mRNA-decapping protein 3 OS=Homo sapiens OX=9606 GN=EDC3 PE=1 SV=1" "0.000" "False" "23.476" "15" "8" "9" "8" "508" "56.0" "7.11" "25.99" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf03853, Pf09532, Pf12701, Pf16598" "80153" "ENSG00000179151" "EDC3" "B3KPH0; D3DW61; hsa:80153; Q96F86; Q9H797" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "0.992" "1.036" "1.019" "1.038" "1.082" "0.983" "0.970" "1.036" "1.091" "730.1" "724.1" "756.4" "743.9" "757.7" "790.2" "717.5" "708.2" "756.5" "796.8" "" "" "" "" "" "" "" "" "" "" "684.1" "599.2" "702.2" "575.1" "645.9" "755.0" "655.6" "628.8" "756.5" "767.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6667619497174905717" "False" "High" "IsMasterProtein" "Q96MW1" "Coiled-coil domain-containing protein 43 OS=Homo sapiens OX=9606 GN=CCDC43 PE=1 SV=2" "0.000" "False" "23.475" "38" "7" "8" "7" "224" "25.2" "4.92" "23.50" "7" "" "cytosol" "" "" "124808" "ENSG00000180329" "CCDC43" "C9JVK9; hsa:124808; Q96MW1" "" "" "0" "0" "1.180" "1.001" "1.064" "1.119" "1.112" "1.115" "1.106" "0.992" "1.050" "652.9" "770.5" "653.4" "694.7" "730.3" "726.1" "728.1" "722.4" "648.0" "685.8" "" "" "" "" "" "" "" "" "" "" "611.8" "637.6" "606.6" "537.1" "622.5" "693.8" "665.3" "641.4" "648.0" "660.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7090269578477503572" "False" "High" "IsMasterProtein" "P29353" "SHC-transforming protein 1 OS=Homo sapiens OX=9606 GN=SHC1 PE=1 SV=4" "0.000" "False" "23.454" "17" "7" "7" "7" "583" "62.8" "6.44" "26.09" "7" "cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00640" "6464" "ENSG00000160691" "SHC1" "B5BU19; D3DV78; hsa:6464; O15290; P29353; Q5T180; Q5T183; Q5T184; Q5T185; Q5T186; Q8N4K5; Q96CL1" "IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL6 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; p38 MAPK signaling pathway; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; EGF/EGFR signaling pathway; Fragile X syndrome; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; GDNF signaling; Macrophage-stimulating protein (MSP) signaling network map; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Interleukin receptor SHC signaling; RET signaling; RAF/MAP kinase cascade; Tie2 Signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; Signaling by CSF3 (G-CSF); XBP1(S) activates chaperone genes; SHC1 events in EGFR signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Integrin signaling; Erythropoietin activates RAS; Signalling to RAS; Signal attenuation; Interleukin-2 signaling; Interleukin-15 signaling" "65" "0" "0.968" "1.030" "1.018" "1.082" "1.007" "0.990" "0.995" "1.006" "1.020" "916.3" "886.7" "943.6" "932.8" "991.7" "922.4" "906.9" "911.9" "922.1" "934.2" "" "" "" "" "" "" "" "" "" "" "858.6" "733.7" "876.1" "721.1" "845.3" "881.3" "828.7" "809.7" "922.1" "899.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3295496481374294049" "False" "High" "IsMasterProtein" "Q9UHD9" "Ubiquilin-2 OS=Homo sapiens OX=9606 GN=UBQLN2 PE=1 SV=2" "0.000" "False" "23.417" "16" "6" "6" "3" "624" "65.7" "5.22" "28.76" "6" "cell organization and biogenesis;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "29978" "ENSG00000188021" "UBQLN2" "hsa:29978; O94798; Q5D027; Q9H3W6; Q9HAZ4; Q9UHD9" "" "Cargo recognition for clathrin-mediated endocytosis" "1" "0" "0.939" "0.809" "1.004" "0.933" "0.999" "0.916" "1.010" "0.883" "0.843" "103.4" "97.0" "83.6" "103.8" "96.5" "103.3" "94.7" "104.4" "91.3" "87.1" "" "" "" "" "" "" "" "" "" "" "96.8" "80.3" "77.6" "80.3" "82.2" "98.7" "86.5" "92.7" "91.3" "83.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5925761923209875400" "False" "High" "IsMasterProtein" "Q12824" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Homo sapiens OX=9606 GN=SMARCB1 PE=1 SV=2" "0.000" "False" "23.408" "21" "7" "10" "7" "385" "44.1" "6.23" "31.65" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04855, Pf21459" "6598" "ENSG00000099956; ENSG00000275837" "SMARCB1" "hsa:6598; O75784; O95474; Q12824; Q17S11; Q38GA1; Q76N08; Q9UBH2" "Tumor suppressor activity of SMARCB1; Thermogenesis; Modulators of TCR signaling and T cell activation; DYRK1A involvement regarding cell proliferation in brain development; Kleefstra syndrome; 10q11.21q11.23 copy number variation syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "8" "0" "1.008" "1.063" "1.098" "1.052" "0.994" "1.070" "1.032" "1.009" "1.047" "440.7" "444.3" "468.5" "484.1" "463.5" "437.9" "471.8" "454.7" "444.8" "461.5" "" "" "" "" "" "" "" "" "" "" "413.0" "367.7" "435.0" "374.2" "395.1" "418.4" "431.1" "403.7" "444.8" "444.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6355678057945092611" "False" "High" "IsMasterProtein" "P42695" "Condensin-2 complex subunit D3 OS=Homo sapiens OX=9606 GN=NCAPD3 PE=1 SV=2" "0.000" "False" "23.357" "6" "11" "13" "11" "1498" "168.8" "7.50" "32.65" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12717" "23310" "ENSG00000151503" "NCAPD3" "A6NFS2; hsa:23310; P42695; Q4KMQ9" "" "Condensation of Prophase Chromosomes" "1" "0" "0.908" "1.026" "1.008" "0.978" "0.951" "0.949" "0.921" "0.912" "0.991" "1225.3" "1112.4" "1256.8" "1234.9" "1198.2" "1165.3" "1162.6" "1128.4" "1117.9" "1214.0" "" "" "" "" "" "" "" "" "" "" "1148.1" "920.5" "1166.8" "954.6" "1021.3" "1113.3" "1062.4" "1001.9" "1117.9" "1168.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-728784246141405942" "False" "High" "IsMasterProtein" "P09543" "2',3'-cyclic-nucleotide 3'-phosphodiesterase OS=Homo sapiens OX=9606 GN=CNP PE=1 SV=2" "0.000" "False" "23.353" "18" "8" "9" "8" "421" "47.5" "9.07" "25.64" "8" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf05881, Pf13671" "1267" "ENSG00000173786" "CNP" "hsa:1267; P09543" "Glial cell differentiation; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Cell lineage map for neuronal differentiation" "" "5" "0" "1.025" "1.066" "0.975" "1.036" "1.038" "0.971" "1.019" "1.033" "1.016" "1012.3" "1037.9" "1079.4" "987.2" "1049.2" "1050.7" "982.6" "1031.3" "1045.9" "1028.5" "" "" "" "" "" "" "" "" "" "" "948.5" "858.9" "1002.0" "763.2" "894.3" "1003.9" "897.8" "915.7" "1045.9" "990.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2821733550000515702" "False" "High" "IsMasterProtein" "Q9NX46" "ADP-ribosylhydrolase ARH3 OS=Homo sapiens OX=9606 GN=ADPRS PE=1 SV=1" "0.000" "False" "23.321" "26" "7" "8" "7" "363" "38.9" "5.07" "24.92" "7" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf03747" "54936" "ENSG00000116863" "ADPRS" "hsa:54936; Q53G94; Q6IAB8; Q9BY47; Q9NX46" "" "POLB-Dependent Long Patch Base Excision Repair" "1" "0" "0.947" "0.944" "1.003" "0.946" "0.962" "0.979" "0.923" "0.920" "0.927" "912.7" "864.0" "861.9" "915.5" "863.4" "878.4" "893.5" "842.1" "839.9" "846.3" "" "" "" "" "" "" "" "" "" "" "855.2" "714.9" "800.1" "707.7" "736.0" "839.2" "816.4" "747.7" "839.9" "814.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4228584982071455131" "False" "High" "IsMasterProtein" "Q92769" "Histone deacetylase 2 OS=Homo sapiens OX=9606 GN=HDAC2 PE=1 SV=2" "0.000" "False" "23.303" "17" "7" "10" "4" "488" "55.3" "5.91" "33.39" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00850" "3066" "ENSG00000196591" "HDAC2" "B3KRS5; B4DL58; E1P561; hsa:3066; Q5SRI8; Q5SZ86; Q8NEH4; Q92769" "Cell cycle; Neural crest differentiation; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Effect of progerin on genes involved in progeria; Ciliary landscape; 7q11.23 copy number variation syndrome; SARS-CoV-2 innate immunity evasion and cell-specific immune response; TAR syndrome; Notch signaling pathway" "Regulation of TP53 Activity through Acetylation; Factors involved in megakaryocyte development and platelet production; Potential therapeutics for SARS; SUMOylation of chromatin organization proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Regulation of PTEN gene transcription; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of MECP2 expression and activity; STAT3 nuclear events downstream of ALK signaling; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; EGR2 and SOX10-mediated initiation of Schwann cell myelination; MECP2 regulates neuronal receptors and channels" "30" "0" "0.971" "1.021" "0.882" "0.960" "0.952" "0.924" "0.994" "1.025" "0.949" "323.8" "314.6" "330.6" "285.6" "311.0" "308.3" "299.1" "322.0" "332.0" "307.4" "" "" "" "" "" "" "" "" "" "" "303.4" "260.3" "306.9" "220.8" "265.1" "294.5" "273.3" "285.9" "332.0" "296.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6159664741780628895" "False" "High" "IsMasterProtein" "Q9P2K3" "REST corepressor 3 OS=Homo sapiens OX=9606 GN=RCOR3 PE=1 SV=2" "0.000" "False" "23.301" "18" "10" "12" "7" "495" "55.5" "8.27" "28.57" "10" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf20878" "55758" "ENSG00000117625" "RCOR3" "B3KYA2; B4DYY7; hsa:55758; Q5VT47; Q7L9I5; Q8N5U3; Q9NV83; Q9P2K3" "" "" "0" "0" "0.944" "0.877" "0.929" "0.881" "1.006" "0.864" "0.923" "0.920" "0.907" "742.7" "701.0" "651.7" "690.3" "654.5" "746.9" "641.5" "685.6" "683.4" "673.3" "" "" "" "" "" "" "" "" "" "" "695.9" "580.0" "605.0" "533.6" "557.9" "713.6" "586.2" "608.8" "683.4" "648.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8198800325193539681" "False" "High" "IsMasterProtein" "P30050" "Large ribosomal subunit protein uL11 OS=Homo sapiens OX=9606 GN=RPL12 PE=1 SV=1" "0.000" "False" "23.279" "58" "7" "7" "7" "165" "17.8" "9.42" "27.74" "7" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00298, Pf03946" "6136" "ENSG00000197958" "RPL12" "hsa:6136; P30050; Q5VVV2; Q6PB27" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.025" "1.096" "1.140" "1.134" "1.167" "1.216" "1.280" "1.248" "1.102" "737.4" "755.9" "807.9" "840.7" "835.9" "860.7" "896.5" "944.0" "920.2" "812.5" "" "" "" "" "" "" "" "" "" "" "690.9" "625.5" "750.0" "649.9" "712.5" "822.3" "819.2" "838.2" "920.2" "782.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9060406091306601688" "False" "High" "IsMasterProtein" "Q8N806" "Putative E3 ubiquitin-protein ligase UBR7 OS=Homo sapiens OX=9606 GN=UBR7 PE=1 SV=2" "0.000" "False" "23.260" "16" "7" "9" "7" "425" "48.0" "4.81" "27.04" "7" "protein metabolism;other metabolic processes" "" "other molecular function" "Pf02207" "55148" "ENSG00000012963; ENSG00000278787" "UBR7" "Q86U21; Q86UA9; Q8N806; Q96BY0; Q9NVV6" "" "" "0" "0" "0.976" "0.989" "0.901" "1.012" "1.015" "0.948" "1.022" "0.968" "0.983" "1631.4" "1591.6" "1612.7" "1470.2" "1651.2" "1655.9" "1547.1" "1667.7" "1579.7" "1603.2" "" "" "" "" "" "" "" "" "" "" "1528.6" "1317.0" "1497.1" "1136.5" "1407.5" "1582.1" "1413.6" "1480.8" "1579.7" "1543.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2041332710814858625" "False" "High" "IsMasterProtein" "Q9NRY4" "Rho GTPase-activating protein 35 OS=Homo sapiens OX=9606 GN=ARHGAP35 PE=1 SV=3" "0.000" "False" "23.258" "6" "8" "10" "8" "1499" "170.4" "6.64" "26.42" "8" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00071, Pf00620, Pf16512, Pf19518" "2909" "ENSG00000160007" "ARHGAP35" "A7E2A4; hsa:2909; Q14452; Q9C0E1; Q9NRY4" "Focal adhesion; Regulation of actin cytoskeleton" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RHOC GTPase cycle; RND2 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Sema4D mediated inhibition of cell attachment and migration; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases" "18" "0" "1.008" "1.050" "1.036" "1.082" "0.995" "0.975" "1.048" "0.987" "1.053" "953.4" "960.7" "1001.2" "988.0" "1031.2" "949.1" "929.3" "998.8" "940.5" "1004.2" "" "" "" "" "" "" "" "" "" "" "893.3" "795.0" "929.5" "763.8" "879.0" "906.7" "849.1" "886.9" "940.5" "966.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3902641514385650329" "False" "High" "IsMasterProtein" "Q5BKZ1" "DBIRD complex subunit ZNF326 OS=Homo sapiens OX=9606 GN=ZNF326 PE=1 SV=2" "0.000" "False" "23.193" "16" "7" "9" "7" "582" "65.6" "5.15" "24.75" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04988" "284695" "ENSG00000162664" "ZNF326" "A8MYX1; B4DLN0; B4E179; hsa:284695; Q5BKZ1; Q5VW93; Q5VW94; Q5VW96; Q5VW97; Q6NSA2; Q7Z638; Q7Z6C2" "" "" "0" "0" "1.073" "1.045" "1.005" "0.961" "0.960" "0.940" "0.905" "0.986" "1.051" "551.7" "591.8" "576.3" "554.5" "530.3" "529.4" "518.7" "499.1" "544.2" "580.1" "" "" "" "" "" "" "" "" "" "" "517.0" "489.7" "535.0" "428.6" "452.0" "505.8" "474.0" "443.2" "544.2" "558.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3263618484320997085" "False" "High" "IsMasterProtein" "Q9H098" "Protein FAM107B OS=Homo sapiens OX=9606 GN=FAM107B PE=1 SV=1" "0.000" "False" "23.174" "47" "7" "12" "7" "131" "15.5" "8.29" "35.43" "7" "" "" "" "Pf06625" "83641" "ENSG00000065809" "FAM107B" "A8K1P4; D3DRT2; hsa:83641; Q5T9K7; Q5T9K8; Q6ZSI4; Q9H098" "" "" "0" "0" "1.014" "0.950" "1.058" "1.054" "0.970" "1.106" "1.120" "1.000" "0.989" "1067.4" "1082.2" "1013.6" "1129.3" "1124.6" "1035.2" "1181.0" "1195.8" "1067.7" "1055.3" "" "" "" "" "" "" "" "" "" "" "1000.1" "895.5" "941.0" "873.0" "958.6" "989.0" "1079.1" "1061.7" "1067.7" "1016.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "609844474726423505" "False" "High" "IsMasterProtein" "P63279" "SUMO-conjugating enzyme UBC9 OS=Homo sapiens OX=9606 GN=UBE2I PE=1 SV=1" "0.000" "False" "23.169" "31" "4" "9" "4" "158" "18.0" "8.66" "23.47" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7329" "ENSG00000103275" "UBE2I" "D3DU69; P50550; P63279; Q15698; Q59GX1; Q86VB3" "Androgen receptor signaling pathway; TGF-beta signaling pathway; TAR syndrome" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of RNA binding proteins; Formation of Incision Complex in GG-NER; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Meiotic synapsis; PKR-mediated signaling; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Processing of DNA double-strand break ends; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; SUMOylation of nuclear envelope proteins; Maturation of nucleoprotein; SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "27" "0" "0.980" "1.011" "0.993" "1.019" "1.093" "0.972" "1.078" "1.022" "1.030" "744.4" "729.5" "752.6" "739.5" "758.6" "813.3" "723.3" "802.4" "760.8" "766.8" "" "" "" "" "" "" "" "" "" "" "697.5" "603.7" "698.7" "571.7" "646.6" "777.1" "660.9" "712.4" "760.8" "738.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2325443013124673649" "False" "High" "IsMasterProtein" "Q6NXE6" "Armadillo repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=ARMC6 PE=1 SV=2" "0.000" "False" "23.147" "17" "8" "11" "8" "501" "54.1" "6.24" "35.69" "8" "other biological processes" "cytosol" "" "Pf00514" "93436" "ENSG00000105676" "ARMC6" "B4DI98; hsa:93436; O94999; Q6NXE6; Q9BTH5" "" "" "0" "0" "0.957" "0.995" "0.935" "0.947" "0.974" "0.863" "0.915" "0.882" "0.930" "663.0" "634.8" "659.5" "619.6" "628.0" "646.1" "572.1" "606.7" "584.6" "616.5" "" "" "" "" "" "" "" "" "" "" "621.3" "525.3" "612.3" "479.0" "535.3" "617.3" "522.8" "538.7" "584.6" "593.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7945611468628581935" "False" "High" "IsMasterProtein" "Q96I25" "Splicing factor 45 OS=Homo sapiens OX=9606 GN=RBM17 PE=1 SV=1" "0.000" "False" "23.140" "20" "8" "10" "7" "401" "44.9" "5.97" "30.47" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf01585" "84991" "ENSG00000134453" "RBM17" "hsa:84991; Q96GY6; Q96I25" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "1" "1.062" "1.091" "1.174" "1.140" "1.125" "1.491" "1.417" "1.372" "1.187" "787.4" "836.3" "859.0" "924.2" "897.4" "885.8" "1174.1" "1115.8" "1080.3" "934.4" "" "" "" "" "" "" "" "" "" "" "737.8" "692.0" "797.5" "714.4" "764.9" "846.3" "1072.8" "990.7" "1080.3" "899.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-726167102893575460" "False" "High" "IsMasterProtein" "Q7Z4H7" "HAUS augmin-like complex subunit 6 OS=Homo sapiens OX=9606 GN=HAUS6 PE=1 SV=2" "0.000" "False" "23.138" "10" "10" "11" "10" "955" "108.6" "6.47" "32.56" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf14661" "54801" "ENSG00000147874" "HAUS6" "B3KPK4; B4DX82; hsa:54801; Q05CG1; Q14CB6; Q14CD9; Q2TA91; Q6IQ10; Q6NZX5; Q7Z4H7; Q8IZQ4; Q96FN0; Q9H950; Q9H998; Q9HCJ8; Q9NXT8" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "1.079" "1.053" "1.095" "1.057" "1.026" "1.014" "0.980" "0.989" "1.062" "1133.5" "1223.5" "1193.7" "1241.1" "1197.6" "1163.1" "1149.1" "1110.6" "1121.2" "1203.3" "" "" "" "" "" "" "" "" "" "" "1062.0" "1012.5" "1108.2" "959.4" "1020.8" "1111.2" "1050.0" "986.1" "1121.2" "1158.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8265724560765906942" "False" "High" "IsMasterProtein" "Q9BVP2" "Guanine nucleotide-binding protein-like 3 OS=Homo sapiens OX=9606 GN=GNL3 PE=1 SV=2" "0.000" "False" "23.138" "13" "8" "11" "7" "549" "62.0" "9.16" "30.68" "8" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01926, Pf08701" "26354" "ENSG00000163938" "GNL3" "B2RDC1; hsa:26354; Q5PU80; Q96SV6; Q96SV7; Q9BVP2; Q9UJY0" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "1" "0.997" "1.017" "0.980" "1.023" "1.041" "0.961" "0.975" "0.929" "1.048" "1791.1" "1785.0" "1820.9" "1755.7" "1831.4" "1864.2" "1721.7" "1745.6" "1663.8" "1877.2" "" "" "" "" "" "" "" "" "" "" "1678.3" "1477.1" "1690.4" "1357.2" "1561.1" "1781.1" "1573.1" "1550.0" "1663.8" "1807.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2874165042467263127" "False" "High" "IsMasterProtein" "Q6PJG6" "BRCA1-associated ATM activator 1 OS=Homo sapiens OX=9606 GN=BRAT1 PE=1 SV=2" "0.000" "False" "23.092" "8" "7" "8" "7" "821" "88.1" "5.27" "25.55" "7" "cell cycle OR cell proliferation;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf02985" "221927" "ENSG00000106009" "BRAT1" "A4D200; C9JY24; hsa:221927; Q6PJG6; Q8IW85; Q8IZ43; Q8WVR8; Q96IV9; Q9H7J8; Q9UFA3" "" "" "0" "0" "1.061" "1.065" "1.069" "1.127" "1.076" "1.015" "0.976" "0.978" "1.051" "246.9" "261.9" "263.0" "264.0" "278.3" "265.6" "250.7" "241.0" "241.4" "259.5" "" "" "" "" "" "" "" "" "" "" "231.3" "216.7" "244.2" "204.1" "237.3" "253.8" "229.1" "214.0" "241.4" "249.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1252831994268086785" "False" "High" "IsMasterProtein" "O00268" "Transcription initiation factor TFIID subunit 4 OS=Homo sapiens OX=9606 GN=TAF4 PE=1 SV=2" "0.000" "False" "23.088" "6" "6" "9" "6" "1085" "110.0" "9.94" "30.59" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf05236, Pf07531" "6874" "ENSG00000130699" "TAF4" "A6NGD9; hsa:6874; O00268; Q5TBP6; Q99721; Q9BR40; Q9BX42" "" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "9" "0" "0.999" "0.943" "1.030" "0.965" "0.984" "0.974" "1.004" "0.989" "0.994" "814.3" "813.4" "768.3" "839.0" "786.0" "801.1" "793.0" "817.7" "805.5" "809.7" "" "" "" "" "" "" "" "" "" "" "763.0" "673.1" "713.3" "648.6" "670.0" "765.4" "724.6" "726.0" "805.5" "779.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1948435004993003441" "False" "High" "IsMasterProtein" "P52594" "Arf-GAP domain and FG repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=AGFG1 PE=1 SV=2" "0.000" "False" "23.085" "15" "7" "11" "7" "562" "58.2" "8.63" "34.70" "7" "cell organization and biogenesis;other metabolic processes;transport" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01412" "3267" "ENSG00000173744" "AGFG1" "B3KUL1; E9PHX7; hsa:3267; P52594; Q15277; Q4VAS0; Q4VAS1; Q4VAS3; Q53QT8; Q53R11" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "1.038" "0.988" "1.073" "1.053" "1.071" "1.096" "1.053" "1.014" "1.093" "633.5" "657.6" "626.1" "680.0" "667.3" "678.5" "694.5" "667.0" "642.3" "692.4" "" "" "" "" "" "" "" "" "" "" "593.6" "544.2" "581.2" "525.7" "568.8" "648.2" "634.6" "592.3" "642.3" "666.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1310996743308863221" "False" "High" "IsMasterProtein" "Q9Y3A5" "Ribosome maturation protein SBDS OS=Homo sapiens OX=9606 GN=SBDS PE=1 SV=4" "0.000" "False" "23.076" "33" "10" "13" "10" "250" "28.7" "8.75" "35.83" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;translation activity;nucleic acid binding activity" "Pf01172, Pf09377, Pf20268" "51119" "ENSG00000126524" "SBDS" "A8K0P4; Q96FX0; Q9NV53; Q9Y3A5" "Genetic causes of porto-sinusoidal vascular disease" "" "1" "0" "0.834" "0.966" "0.929" "0.939" "0.968" "0.969" "0.939" "0.905" "0.942" "1569.3" "1308.8" "1516.3" "1458.0" "1473.2" "1519.1" "1520.9" "1474.2" "1420.5" "1478.7" "" "" "" "" "" "" "" "" "" "" "1470.4" "1083.0" "1407.6" "1127.1" "1255.7" "1451.4" "1389.7" "1308.9" "1420.5" "1423.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "380147253527428052" "False" "High" "IsMasterProtein" "Q9NRR5" "Ubiquilin-4 OS=Homo sapiens OX=9606 GN=UBQLN4 PE=1 SV=2" "0.000" "False" "23.056" "20" "7" "8" "5" "601" "63.8" "5.22" "35.88" "7" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "56893" "ENSG00000160803" "UBQLN4" "A6ND44; B2RAY7; hsa:56893; Q5VYA0; Q5VYA1; Q9BR98; Q9NRR5; Q9UHX4" "" "" "0" "0" "1.038" "0.997" "1.079" "1.014" "1.013" "1.055" "1.024" "0.939" "0.995" "376.2" "390.4" "374.9" "405.9" "381.4" "381.2" "397.0" "385.4" "353.1" "374.5" "" "" "" "" "" "" "" "" "" "" "352.5" "323.1" "348.1" "313.7" "325.1" "364.2" "362.8" "342.2" "353.1" "360.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7181785604482644820" "False" "High" "IsMasterProtein" "Q9NR50" "Translation initiation factor eIF2B subunit gamma OS=Homo sapiens OX=9606 GN=EIF2B3 PE=1 SV=1" "0.000" "False" "23.056" "16" "8" "10" "8" "452" "50.2" "6.47" "33.97" "8" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00483" "8891" "ENSG00000070785" "EIF2B3" "B2RBH8; D3DPZ2; hsa:8891; Q5QP89; Q5QP90; Q8NDB5; Q8WV57; Q9H850; Q9NR50" "Translation factors; Primary ovarian insufficiency" "Recycling of eIF2:GDP" "3" "0" "0.968" "0.981" "0.970" "0.916" "0.973" "0.908" "0.934" "0.890" "0.925" "1369.2" "1325.0" "1342.8" "1327.6" "1254.7" "1331.9" "1243.0" "1278.8" "1218.9" "1267.0" "" "" "" "" "" "" "" "" "" "" "1283.0" "1096.4" "1246.7" "1026.3" "1069.5" "1272.5" "1135.8" "1135.4" "1218.9" "1219.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9034564449228548140" "False" "High" "IsMasterProtein" "O75223" "Gamma-glutamylcyclotransferase OS=Homo sapiens OX=9606 GN=GGCT PE=1 SV=1" "0.000" "False" "23.038" "35" "6" "11" "6" "188" "21.0" "5.14" "36.43" "6" "cell organization and biogenesis;signal transduction" "cytosol" "other molecular function" "Pf13772" "79017" "ENSG00000006625" "GGCT" "B2RDN0; B8ZZN4; B8ZZR8; hsa:79017; O75223; Q9BS37" "" "Glutathione synthesis and recycling" "1" "0" "1.081" "1.035" "1.107" "1.052" "1.076" "0.992" "1.095" "1.000" "1.050" "832.2" "899.3" "861.5" "921.3" "875.0" "895.0" "825.6" "911.3" "832.3" "873.5" "" "" "" "" "" "" "" "" "" "" "779.7" "744.2" "799.7" "712.2" "745.9" "855.1" "754.4" "809.2" "832.3" "841.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "636638520442762569" "False" "High" "IsMasterProtein" "P54725" "UV excision repair protein RAD23 homolog A OS=Homo sapiens OX=9606 GN=RAD23A PE=1 SV=1" "0.000" "False" "23.036" "26" "8" "15" "6" "363" "39.6" "4.58" "44.37" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00627, Pf09280" "5886" "ENSG00000179262" "RAD23A" "hsa:5886; K7ESE3; P54725; Q59EU8; Q5M7Z1" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Josephin domain DUBs; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "6" "0" "1.170" "0.959" "1.082" "1.065" "1.053" "1.063" "1.046" "1.075" "1.068" "1180.9" "1381.8" "1132.9" "1277.2" "1257.7" "1243.7" "1254.8" "1234.7" "1269.1" "1260.8" "" "" "" "" "" "" "" "" "" "" "1106.5" "1143.4" "1051.8" "987.3" "1072.0" "1188.2" "1146.5" "1096.3" "1269.1" "1213.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3464884523288308990" "False" "High" "IsMasterProtein" "Q12972" "Nuclear inhibitor of protein phosphatase 1 OS=Homo sapiens OX=9606 GN=PPP1R8 PE=1 SV=2" "0.000" "False" "23.029" "23" "7" "11" "7" "351" "38.5" "7.37" "46.71" "7" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00498" "5511" "ENSG00000117751" "PPP1R8" "hsa:5511; Q12972; Q5TEJ2; Q5TEJ4; Q5TIF2; Q6PKF6; Q9UBH1; Q9UBZ0" "" "mRNA Splicing - Major Pathway" "1" "0" "1.052" "1.007" "1.014" "1.056" "1.040" "0.992" "1.054" "0.957" "1.022" "1925.0" "2025.5" "1939.2" "1952.1" "2032.5" "2002.7" "1910.1" "2028.1" "1842.9" "1967.7" "" "" "" "" "" "" "" "" "" "" "1803.7" "1676.1" "1800.3" "1509.1" "1732.5" "1913.4" "1745.3" "1800.8" "1842.9" "1894.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-34001002036977343" "False" "High" "IsMasterProtein" "O76003" "Glutaredoxin-3 OS=Homo sapiens OX=9606 GN=GLRX3 PE=1 SV=2" "0.000" "False" "23.007" "22" "7" "9" "7" "335" "37.4" "5.39" "32.00" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00085, Pf00462" "10539" "ENSG00000108010" "GLRX3" "B3KMP7; B3KMQ5; D3DRG2; hsa:10539; O76003; Q5JV01; Q96CE0; Q9P1B0; Q9P1B1" "" "Iron uptake and transport" "1" "0" "0.981" "1.015" "1.014" "1.024" "1.057" "0.982" "1.022" "1.066" "1.041" "936.5" "919.0" "951.0" "949.6" "958.9" "990.0" "919.6" "957.0" "998.1" "974.5" "" "" "" "" "" "" "" "" "" "" "877.5" "760.5" "882.9" "734.1" "817.4" "945.8" "840.2" "849.7" "998.1" "938.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8139328666383470964" "False" "High" "IsMasterProtein" "Q8IZH2" "5'-3' exoribonuclease 1 OS=Homo sapiens OX=9606 GN=XRN1 PE=1 SV=1" "0.000" "False" "22.986" "5" "8" "8" "8" "1706" "194.0" "7.21" "24.96" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03159, Pf17846, Pf18129, Pf18332, Pf18334" "54464" "ENSG00000114127" "XRN1" "hsa:54464; Q4G0S3; Q68D88; Q6AI24; Q6MZS8; Q86WS7; Q8IZH2; Q8N8U4; Q9UF39" "miRNA degrading enzymes" "mRNA decay by 5' to 3' exoribonuclease; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "4" "0" "1.012" "0.991" "1.069" "0.980" "0.977" "1.030" "1.019" "1.002" "0.968" "504.0" "510.3" "499.4" "539.0" "494.0" "492.6" "518.9" "513.6" "504.9" "487.7" "" "" "" "" "" "" "" "" "" "" "472.3" "422.3" "463.7" "416.7" "421.1" "470.7" "474.2" "456.0" "504.9" "469.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-220187434067665020" "False" "High" "IsMasterProtein" "Q6PJT7" "Zinc finger CCCH domain-containing protein 14 OS=Homo sapiens OX=9606 GN=ZC3H14 PE=1 SV=1" "0.000" "False" "22.967" "10" "7" "10" "7" "736" "82.8" "7.31" "35.49" "7" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf14608" "79882" "ENSG00000100722" "ZC3H14" "A8MY46; B4DXU8; B4DZW7; B4E2H4; G3V5R4; hsa:79882; Q6MZU4; Q6PJ32; Q6PJT7; Q6PUI6; Q6PUI8; Q86TQ5; Q86TW0; Q86TW1; Q8NCT6; Q8NCZ3; Q8TDE2; Q9HAC9; Q9Y5A0" "" "" "0" "0" "1.071" "1.010" "1.182" "1.117" "1.108" "1.297" "1.377" "1.197" "1.166" "457.5" "490.1" "462.0" "540.7" "511.1" "506.9" "593.4" "629.8" "547.8" "533.2" "" "" "" "" "" "" "" "" "" "" "428.7" "405.5" "428.9" "418.0" "435.6" "484.3" "542.2" "559.2" "547.8" "513.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3476317971320699033" "False" "High" "IsMasterProtein" "O43156" "TELO2-interacting protein 1 homolog OS=Homo sapiens OX=9606 GN=TTI1 PE=1 SV=3" "0.000" "False" "22.956" "6" "7" "9" "7" "1089" "122.0" "5.97" "27.99" "7" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf21547" "9675" "ENSG00000101407" "TTI1" "D6W4K3; hsa:9675; O43156; Q5JX67; Q96A38; Q9BR47; Q9H4K0" "Fragile X syndrome; Pleural mesothelioma" "" "2" "0" "0.990" "1.033" "1.095" "1.047" "1.047" "1.010" "0.962" "0.942" "1.047" "738.4" "730.9" "762.8" "808.9" "773.0" "773.3" "746.0" "710.1" "695.3" "773.2" "" "" "" "" "" "" "" "" "" "" "691.9" "604.8" "708.2" "625.3" "658.9" "738.8" "681.7" "630.5" "695.3" "744.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1708640290626267049" "False" "High" "IsMasterProtein" "P37108" "Signal recognition particle 14 kDa protein OS=Homo sapiens OX=9606 GN=SRP14 PE=1 SV=2" "0.000" "False" "22.955" "56" "7" "11" "7" "136" "14.6" "10.04" "42.80" "7" "other biological processes" "non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02290" "6727" "ENSG00000140319" "SRP14" "B5BUF5; hsa:6727; P37108; Q6B0K5; Q96Q14" "" "Neutrophil degranulation; SRP-dependent cotranslational protein targeting to membrane" "2" "0" "1.134" "1.110" "1.023" "1.100" "1.072" "1.044" "1.158" "1.124" "1.052" "994.3" "1127.4" "1103.9" "1017.3" "1093.4" "1066.0" "1037.9" "1151.5" "1117.7" "1046.4" "" "" "" "" "" "" "" "" "" "" "931.6" "932.9" "1024.9" "786.4" "932.0" "1018.4" "948.4" "1022.4" "1117.7" "1007.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-105519067553436175" "False" "High" "IsMasterProtein" "Q04323" "UBX domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBXN1 PE=1 SV=2" "0.000" "False" "22.951" "33" "8" "12" "8" "297" "33.3" "5.25" "41.08" "8" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00627, Pf00789" "51035" "ENSG00000162191" "UBXN1" "hsa:51035; Q04323; Q9BV93; Q9BVV5" "" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "2" "0" "1.164" "1.002" "0.984" "1.066" "1.088" "0.984" "1.030" "1.124" "1.046" "375.0" "436.6" "375.6" "369.1" "399.8" "408.2" "369.0" "386.3" "421.3" "392.2" "" "" "" "" "" "" "" "" "" "" "351.4" "361.3" "348.7" "285.3" "340.8" "390.0" "337.1" "343.0" "421.3" "377.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9128345059399950903" "False" "High" "IsMasterProtein" "P83436" "Conserved oligomeric Golgi complex subunit 7 OS=Homo sapiens OX=9606 GN=COG7 PE=1 SV=1" "0.000" "False" "22.940" "9" "8" "9" "8" "770" "86.3" "5.47" "30.68" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "" "Pf10191" "91949" "ENSG00000168434" "COG7" "hsa:91949; P83436; Q6UWU7" "" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "3" "0" "1.008" "1.030" "1.076" "1.036" "1.028" "1.016" "0.991" "0.998" "1.049" "1174.4" "1183.6" "1210.1" "1263.6" "1217.0" "1206.8" "1193.1" "1164.0" "1171.6" "1232.1" "" "" "" "" "" "" "" "" "" "" "1100.4" "979.4" "1123.5" "976.8" "1037.3" "1153.0" "1090.1" "1033.5" "1171.6" "1186.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6302515266357767192" "False" "High" "IsMasterProtein" "Q9NR46" "Endophilin-B2 OS=Homo sapiens OX=9606 GN=SH3GLB2 PE=1 SV=1" "0.000" "False" "22.938" "20" "8" "9" "7" "395" "43.9" "5.99" "30.17" "8" "cell organization and biogenesis" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03114, Pf14604" "56904" "ENSG00000148341" "SH3GLB2" "A6NC47; A8MPS4; hsa:56904; Q8WY61; Q96JH9; Q9NR46" "" "" "0" "1" "0.995" "0.991" "0.983" "0.980" "0.980" "0.924" "0.961" "0.946" "0.968" "1310.1" "1303.2" "1298.0" "1287.8" "1283.7" "1283.8" "1210.4" "1259.5" "1239.6" "1268.0" "" "" "" "" "" "" "" "" "" "" "1227.6" "1078.4" "1205.0" "995.5" "1094.2" "1226.6" "1105.9" "1118.3" "1239.6" "1220.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4190434278171363026" "False" "High" "IsMasterProtein" "Q92547" "DNA topoisomerase 2-binding protein 1 OS=Homo sapiens OX=9606 GN=TOPBP1 PE=1 SV=3" "0.000" "False" "22.919" "5" "8" "9" "8" "1522" "170.6" "6.96" "27.73" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00533" "11073" "ENSG00000163781" "TOPBP1" "B7Z7W8; hsa:11073; Q7LGC1; Q92547; Q9UEB9" "ATR signaling" "Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "7" "0" "1.012" "1.050" "1.019" "1.223" "1.085" "1.079" "1.078" "1.062" "1.074" "1285.0" "1300.8" "1348.7" "1310.0" "1571.7" "1394.0" "1386.1" "1385.2" "1364.8" "1379.8" "" "" "" "" "" "" "" "" "" "" "1204.0" "1076.4" "1252.1" "1012.7" "1339.7" "1331.9" "1266.5" "1229.9" "1364.8" "1328.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5869916031675078190" "False" "High" "IsMasterProtein" "O95486" "Protein transport protein Sec24A OS=Homo sapiens OX=9606 GN=SEC24A PE=1 SV=2" "0.000" "False" "22.898" "7" "7" "9" "7" "1093" "119.7" "7.66" "30.88" "7" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10802" "ENSG00000113615" "SEC24A" "A8MVW3; hsa:10802; O95486; Q8WUV2; Q96GP7" "Sterol regulatory element-binding proteins (SREBP) signaling" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "7" "0" "1.067" "1.048" "1.129" "1.131" "1.049" "1.024" "1.008" "1.033" "1.054" "450.1" "480.2" "471.5" "508.3" "509.0" "472.0" "461.0" "453.5" "464.9" "474.1" "" "" "" "" "" "" "" "" "" "" "421.7" "397.3" "437.7" "393.0" "433.9" "451.0" "421.2" "402.6" "464.9" "456.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3711449830735196489" "False" "High" "IsMasterProtein" "Q9BZJ0" "Crooked neck-like protein 1 OS=Homo sapiens OX=9606 GN=CRNKL1 PE=1 SV=4" "0.000" "False" "22.895" "9" "8" "12" "8" "848" "100.4" "8.00" "41.63" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf02184" "51340" "ENSG00000101343" "CRNKL1" "A8K9T4; hsa:51340; Q5JY64; Q8WYI5; Q9BZI9; Q9BZJ0; Q9BZJ1; Q9BZJ2; Q9GZW7; Q9H8F8; Q9NQH5; Q9NYD8" "" "mRNA Splicing - Major Pathway" "1" "0" "0.931" "0.964" "0.969" "0.976" "0.955" "0.935" "0.921" "0.904" "0.994" "1140.1" "1061.0" "1099.3" "1104.4" "1112.2" "1088.9" "1066.2" "1050.0" "1030.9" "1133.3" "" "" "" "" "" "" "" "" "" "" "1068.2" "877.9" "1020.5" "853.7" "948.0" "1040.3" "974.2" "932.3" "1030.9" "1091.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6467566476375476721" "False" "High" "IsMasterProtein" "Q03154" "Aminoacylase-1 OS=Homo sapiens OX=9606 GN=ACY1 PE=1 SV=1" "0.000" "False" "22.868" "19" "7" "11" "7" "408" "45.9" "6.18" "32.14" "7" "other metabolic processes" "non-structural extracellular;cytosol" "other molecular function" "Pf01546, Pf07687" "95" "ENSG00000243989" "ACY1" "C9J6I6; C9J9D8; C9JWD4; hsa:95; Q03154" "Thyroxine (thyroid hormone) production" "Aflatoxin activation and detoxification; Paracetamol ADME; Defective ACY1 causes encephalopathy" "4" "0" "1.105" "1.075" "1.188" "1.114" "1.074" "1.135" "1.049" "1.061" "1.012" "309.0" "341.3" "332.3" "367.1" "344.1" "331.7" "350.7" "324.2" "327.8" "312.7" "" "" "" "" "" "" "" "" "" "" "289.5" "282.4" "308.5" "283.8" "293.3" "317.0" "320.5" "287.9" "327.8" "301.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4678408440687391789" "False" "High" "IsMasterProtein" "Q9UFW8" "CGG triplet repeat-binding protein 1 OS=Homo sapiens OX=9606 GN=CGGBP1 PE=1 SV=2" "0.000" "False" "22.863" "47" "7" "9" "7" "167" "18.8" "8.95" "32.54" "7" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "8545" "ENSG00000163320" "CGGBP1" "D3DU38; hsa:8545; O15183; Q9UFW8" "" "" "0" "0" "1.105" "1.039" "1.048" "1.096" "1.070" "1.051" "1.132" "1.056" "1.033" "1704.6" "1883.8" "1771.4" "1786.8" "1868.9" "1823.8" "1790.8" "1929.8" "1799.5" "1760.8" "" "" "" "" "" "" "" "" "" "" "1597.2" "1558.8" "1644.5" "1381.2" "1593.0" "1742.5" "1636.3" "1713.5" "1799.5" "1695.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5613056624096108144" "False" "High" "IsMasterProtein" "Q7Z7E8" "Ubiquitin-conjugating enzyme E2 Q1 OS=Homo sapiens OX=9606 GN=UBE2Q1 PE=1 SV=1" "0.000" "False" "22.862" "20" "9" "11" "9" "422" "46.1" "5.10" "32.30" "9" "cell-cell signaling;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "55585" "ENSG00000160714" "UBE2Q1" "B4DF92; hsa:55585; Q29SN7; Q3B841; Q5I0X2; Q6IS04; Q6P7P2; Q7Z7E8; Q96MV4; Q9BVX5; Q9UGL6" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.886" "0.938" "0.925" "0.923" "0.933" "0.972" "0.915" "0.911" "0.955" "1239.9" "1098.3" "1162.4" "1146.4" "1144.3" "1156.6" "1204.9" "1134.5" "1129.3" "1183.8" "" "" "" "" "" "" "" "" "" "" "1161.8" "908.8" "1079.1" "886.3" "975.4" "1105.1" "1100.9" "1007.3" "1129.3" "1139.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7869799461247912985" "False" "High" "IsMasterProtein" "Q96GW9" "Methionine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=MARS2 PE=1 SV=2" "0.000" "False" "22.861" "15" "9" "11" "9" "593" "66.5" "8.09" "29.73" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf09334, Pf19303" "92935" "ENSG00000247626" "MARS2" "A0AVC3; hsa:92935; Q76E79; Q8IW62; Q8N7N4; Q96GW9" "Amino acid metabolism" "Mitochondrial tRNA aminoacylation" "2" "0" "1.055" "1.092" "1.156" "1.076" "1.072" "1.059" "1.072" "1.065" "1.083" "1064.9" "1123.8" "1163.3" "1230.8" "1146.0" "1141.8" "1128.1" "1141.4" "1134.4" "1153.7" "" "" "" "" "" "" "" "" "" "" "997.8" "929.9" "1080.0" "951.4" "976.8" "1090.8" "1030.8" "1013.5" "1134.4" "1110.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-986396495116814729" "False" "High" "IsMasterProtein" "Q8IZ69" "tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens OX=9606 GN=TRMT2A PE=1 SV=2" "0.000" "False" "22.836" "15" "8" "8" "8" "625" "68.7" "7.94" "26.81" "8" "RNA metabolism OR transcription;other metabolic processes" "cytosol" "other molecular function" "Pf05958" "27037" "ENSG00000099899" "TRMT2A" "D3DX25; hsa:27037; Q32P57; Q8IZ69; Q96ME6; Q9H732" "22q11.2 copy number variation syndrome" "" "1" "0" "0.993" "0.981" "1.065" "1.037" "1.065" "1.041" "1.016" "1.043" "1.025" "664.1" "659.6" "651.2" "707.0" "688.9" "707.2" "691.0" "674.9" "693.0" "680.9" "" "" "" "" "" "" "" "" "" "" "622.2" "545.8" "604.5" "546.6" "587.2" "675.7" "631.4" "599.2" "693.0" "655.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1992212741193317441" "False" "High" "IsMasterProtein" "Q13247" "Serine/arginine-rich splicing factor 6 OS=Homo sapiens OX=9606 GN=SRSF6 PE=1 SV=2" "0.000" "False" "22.836" "20" "8" "11" "4" "344" "39.6" "11.43" "33.24" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076" "6431" "ENSG00000124193" "SRSF6" "B7Z6J3; E1P5W6; hsa:6431; Q13244; Q13245; Q13247; Q96J06; Q9UJB8; Q9Y3N7" "mRNA processing" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "7" "0" "1.211" "1.116" "0.854" "0.999" "1.095" "1.139" "1.232" "1.309" "1.122" "290.4" "351.8" "324.2" "248.0" "290.1" "318.0" "330.8" "357.8" "380.3" "325.8" "" "" "" "" "" "" "" "" "" "" "272.1" "291.1" "301.0" "191.7" "247.3" "303.8" "302.3" "317.7" "380.3" "313.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491360545906137157" "False" "High" "IsMasterProtein" "P54920" "Alpha-soluble NSF attachment protein OS=Homo sapiens OX=9606 GN=NAPA PE=1 SV=3" "0.000" "False" "22.827" "24" "6" "9" "6" "295" "33.2" "5.36" "27.97" "6" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf14938" "8775" "ENSG00000105402" "NAPA" "A8K879; hsa:8775; P54920; Q96IK3; Q9BVJ3" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Golgi Associated Vesicle Biogenesis; Intra-Golgi traffic; COPII-mediated vesicle transport; Retrograde transport at the Trans-Golgi-Network" "8" "0" "1.002" "1.000" "1.038" "1.107" "1.088" "1.010" "1.104" "1.102" "1.044" "417.5" "418.1" "417.4" "433.4" "462.0" "454.3" "421.7" "461.0" "460.0" "435.7" "" "" "" "" "" "" "" "" "" "" "391.2" "346.0" "387.5" "335.1" "393.8" "434.1" "385.4" "409.3" "460.0" "419.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "568464796837822948" "False" "High" "IsMasterProtein" "O43823" "A-kinase anchor protein 8 OS=Homo sapiens OX=9606 GN=AKAP8 PE=1 SV=1" "0.000" "False" "22.826" "11" "7" "7" "7" "692" "76.1" "5.15" "23.86" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04988" "10270" "ENSG00000105127" "AKAP8" "hsa:10270; O43823" "G protein signaling pathways" "" "1" "0" "0.925" "1.000" "1.005" "1.054" "1.023" "1.080" "1.045" "0.968" "1.024" "1243.7" "1150.2" "1243.4" "1250.0" "1311.3" "1272.3" "1343.0" "1299.8" "1203.4" "1274.1" "" "" "" "" "" "" "" "" "" "" "1165.3" "951.8" "1154.3" "966.3" "1117.7" "1215.5" "1227.1" "1154.1" "1203.4" "1226.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5911471042018297925" "False" "High" "IsMasterProtein" "Q8ND56" "Protein LSM14 homolog A OS=Homo sapiens OX=9606 GN=LSM14A PE=1 SV=3" "0.000" "False" "22.823" "14" "7" "11" "7" "463" "50.5" "9.52" "29.95" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "nucleic acid binding activity" "Pf09532, Pf12701" "26065" "ENSG00000257103; ENSG00000262860" "LSM14A" "B4DTG6; hsa:26065; Q76LX7; Q8ND56; Q96AR3; Q96K73; Q96SN5; Q9UFR3" "" "" "0" "0" "1.060" "1.047" "1.084" "1.086" "1.100" "1.040" "1.059" "1.038" "1.089" "818.9" "868.1" "857.8" "887.7" "889.3" "901.0" "851.4" "867.4" "850.3" "891.7" "" "" "" "" "" "" "" "" "" "" "767.3" "718.3" "796.4" "686.2" "758.0" "860.8" "778.0" "770.2" "850.3" "858.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2765155610572928931" "False" "High" "IsMasterProtein" "Q8IZ73" "Pseudouridylate synthase RPUSD2 OS=Homo sapiens OX=9606 GN=RPUSD2 PE=1 SV=2" "0.000" "False" "22.792" "17" "7" "9" "7" "545" "61.3" "7.17" "24.44" "7" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00849" "27079" "ENSG00000166133" "RPUSD2" "B4DDD1; hsa:27079; Q7L989; Q8IZ73; Q92939; Q96IA7; Q96N50" "" "" "0" "0" "1.069" "1.073" "1.127" "1.135" "1.127" "0.998" "1.089" "1.129" "1.118" "304.5" "325.4" "326.8" "343.2" "345.6" "343.2" "303.9" "331.4" "343.9" "340.5" "" "" "" "" "" "" "" "" "" "" "285.3" "269.3" "303.4" "265.3" "294.5" "327.9" "277.6" "294.3" "343.9" "327.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5831318780158998432" "False" "High" "IsMasterProtein" "Q9H0C8" "Integrin-linked kinase-associated serine/threonine phosphatase 2C OS=Homo sapiens OX=9606 GN=ILKAP PE=1 SV=1" "0.000" "False" "22.791" "19" "9" "11" "9" "392" "42.9" "7.09" "35.70" "9" "" "other cell component" "other molecular function" "Pf00481" "80895" "ENSG00000132323" "ILKAP" "B3KM39; hsa:80895; Q9H0C8" "2q37 copy number variation syndrome" "" "1" "0" "0.949" "1.003" "0.946" "0.944" "1.025" "0.965" "0.960" "0.982" "0.984" "2021.6" "1918.6" "2028.1" "1913.2" "1908.9" "2072.8" "1950.9" "1940.1" "1985.1" "1989.4" "" "" "" "" "" "" "" "" "" "" "1894.2" "1587.6" "1882.9" "1479.0" "1627.1" "1980.3" "1782.6" "1722.6" "1985.1" "1915.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6182186368676627238" "False" "High" "IsMasterProtein" "Q13405" "Large ribosomal subunit protein mL49 OS=Homo sapiens OX=9606 GN=MRPL49 PE=1 SV=1" "0.000" "False" "22.789" "33" "5" "8" "5" "166" "19.2" "9.45" "22.50" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf05046" "740" "ENSG00000149792" "MRPL49" "B2R4G6; hsa:740; Q13405" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.943" "1.069" "0.959" "1.024" "1.226" "0.971" "1.100" "1.081" "1.099" "720.6" "679.7" "770.5" "690.8" "737.9" "883.5" "700.0" "792.3" "779.3" "791.7" "" "" "" "" "" "" "" "" "" "" "675.2" "562.4" "715.3" "534.0" "629.0" "844.1" "639.6" "703.5" "779.3" "762.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8066723703653811047" "False" "High" "IsMasterProtein" "P53814" "Smoothelin OS=Homo sapiens OX=9606 GN=SMTN PE=1 SV=7" "0.000" "False" "22.784" "9" "9" "10" "9" "917" "99.0" "9.07" "25.13" "9" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf12510" "6525" "ENSG00000183963" "SMTN" "hsa:6525; O00569; O95769; O95937; P53814; Q8N4H8; Q8WWW1; Q8WWW2; Q9P1S8; Q9UIT1; Q9UIT2" "" "" "0" "0" "1.022" "0.973" "0.975" "1.066" "1.006" "0.959" "0.905" "0.989" "0.966" "457.6" "467.8" "445.3" "446.1" "487.9" "460.4" "438.8" "414.1" "452.5" "442.2" "" "" "" "" "" "" "" "" "" "" "428.8" "387.1" "413.4" "344.9" "415.9" "439.9" "400.9" "367.7" "452.5" "425.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "567113707807287491" "False" "High" "IsMasterProtein" "Q8NBT2" "Kinetochore protein Spc24 OS=Homo sapiens OX=9606 GN=SPC24 PE=1 SV=3" "0.000" "False" "22.764" "31" "5" "10" "5" "197" "22.4" "4.70" "36.24" "5" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf08286" "147841" "ENSG00000161888" "SPC24" "B4DZZ7; C9JGC4; hsa:147841; Q8NBT2" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.008" "0.957" "1.036" "1.015" "1.028" "0.944" "0.958" "0.972" "0.998" "899.3" "906.5" "860.6" "932.0" "913.3" "924.3" "848.6" "861.8" "874.3" "897.9" "" "" "" "" "" "" "" "" "" "" "842.7" "750.1" "799.0" "720.5" "778.4" "883.1" "775.4" "765.2" "874.3" "864.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5623462440984321357" "False" "High" "IsMasterProtein" "Q96CW5" "Gamma-tubulin complex component 3 OS=Homo sapiens OX=9606 GN=TUBGCP3 PE=1 SV=2" "0.000" "False" "22.762" "8" "8" "11" "8" "907" "103.5" "8.12" "31.81" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04130, Pf17681" "10426" "ENSG00000126216" "TUBGCP3" "hsa:10426; O43631; O60852; O60853; Q5T8L2; Q7Z4K1; Q96CW5; Q96I79" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "4" "0" "0.884" "0.878" "0.916" "0.925" "0.914" "0.914" "0.900" "0.810" "0.803" "1189.1" "1051.2" "1044.2" "1089.3" "1099.6" "1086.9" "1086.3" "1070.1" "962.7" "954.5" "" "" "" "" "" "" "" "" "" "" "1114.1" "869.9" "969.5" "842.1" "937.3" "1038.5" "992.6" "950.2" "962.7" "919.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1819125433981479748" "False" "High" "IsMasterProtein" "Q15404" "Ras suppressor protein 1 OS=Homo sapiens OX=9606 GN=RSU1 PE=1 SV=3" "0.000" "False" "22.756" "28" "8" "15" "8" "277" "31.5" "8.65" "34.91" "8" "signal transduction;other biological processes" "cytosol;other cell component" "" "Pf13855" "6251" "ENSG00000148484" "RSU1" "A8KA46; D3DRU3; hsa:6251; Q15404; Q6FI17" "" "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "1" "0" "0.947" "0.997" "1.081" "1.016" "1.029" "1.003" "0.975" "0.989" "1.037" "980.1" "928.0" "976.7" "1059.8" "995.7" "1008.1" "983.5" "955.7" "969.5" "1016.6" "" "" "" "" "" "" "" "" "" "" "918.3" "767.9" "906.8" "819.2" "848.7" "963.1" "898.7" "848.6" "969.5" "978.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1837878793854205649" "False" "High" "IsMasterProtein" "Q9BVL2" "Nucleoporin p58/p45 OS=Homo sapiens OX=9606 GN=NUP58 PE=1 SV=1" "0.000" "False" "22.712" "12" "7" "11" "7" "599" "60.9" "9.33" "33.67" "7" "transport;other biological processes" "other membranes;nucleus" "other molecular function" "Pf15967" "9818" "ENSG00000139496" "NUP58" "A6NI12; B4DZJ1; hsa:9818; O43160; Q5JRG2; Q5JRG5; Q9BVL2" "" "" "0" "0" "0.965" "1.007" "1.078" "1.078" "1.123" "1.075" "1.096" "1.097" "1.057" "624.5" "602.7" "628.6" "673.3" "673.3" "701.0" "671.5" "684.3" "685.3" "660.3" "" "" "" "" "" "" "" "" "" "" "585.1" "498.8" "583.6" "520.5" "573.9" "669.7" "613.6" "607.6" "685.3" "635.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-77584884133553683" "False" "High" "IsMasterProtein" "Q9UMY4" "Sorting nexin-12 OS=Homo sapiens OX=9606 GN=SNX12 PE=1 SV=4" "0.000" "False" "22.711" "40" "7" "12" "5" "162" "18.9" "8.44" "31.64" "7" "transport;other biological processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00787" "29934" "ENSG00000147164" "SNX12" "F8W8K5; hsa:29934; Q8WUG9; Q9UMY4" "" "" "0" "0" "0.964" "0.983" "0.923" "0.982" "0.982" "0.944" "0.969" "0.996" "0.965" "707.0" "681.5" "694.8" "652.3" "694.3" "694.1" "667.1" "684.8" "704.2" "682.4" "" "" "" "" "" "" "" "" "" "" "662.5" "563.9" "645.0" "504.2" "591.8" "663.2" "609.6" "608.1" "704.2" "657.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2846560637843554470" "False" "High" "IsMasterProtein" "O14579" "Coatomer subunit epsilon OS=Homo sapiens OX=9606 GN=COPE PE=1 SV=3" "0.000" "False" "22.696" "26" "7" "9" "7" "308" "34.5" "5.12" "31.34" "7" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus" "other molecular function" "Pf04733" "11316" "ENSG00000105669" "COPE" "A6NE29; A6NKA3; hsa:11316; O14579; O76097; Q6IBB8; Q9UGP6" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "1.015" "1.007" "1.074" "1.070" "1.064" "0.959" "1.065" "1.046" "1.001" "541.5" "549.8" "545.2" "581.4" "579.6" "576.2" "519.5" "576.6" "566.3" "541.9" "" "" "" "" "" "" "" "" "" "" "507.4" "454.9" "506.2" "449.5" "494.1" "550.5" "474.7" "512.0" "566.3" "521.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8321429417116917544" "False" "High" "IsMasterProtein" "P07339" "Cathepsin D OS=Homo sapiens OX=9606 GN=CTSD PE=1 SV=1" "0.000" "False" "22.689" "15" "7" "14" "7" "412" "44.5" "6.54" "45.33" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00026, Pf07966" "1509" "ENSG00000117984" "CTSD" "hsa:1509; P07339; Q6IB57" "Prolactin signaling pathway; 8p23.1 copy number variation syndrome" "Neutrophil degranulation; MHC class II antigen presentation; Collagen degradation; Estrogen-dependent gene expression; Insulin receptor recycling; Metabolism of Angiotensinogen to Angiotensins" "8" "0" "1.105" "1.026" "1.050" "1.061" "1.085" "1.061" "1.068" "1.050" "1.031" "582.5" "643.9" "597.8" "611.9" "618.0" "632.1" "618.3" "621.9" "611.4" "600.5" "" "" "" "" "" "" "" "" "" "" "545.8" "532.8" "555.0" "473.0" "526.8" "603.9" "564.9" "552.2" "611.4" "578.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-644721245290312006" "False" "High" "IsMasterProtein" "Q9UNS2" "COP9 signalosome complex subunit 3 OS=Homo sapiens OX=9606 GN=COPS3 PE=1 SV=3" "0.000" "False" "22.674" "20" "7" "9" "7" "423" "47.8" "6.65" "22.14" "7" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf21215" "8533" "ENSG00000141030" "COPS3" "B2R683; B4DY81; hsa:8533; O43191; Q7LDR6; Q9UNS2" "Ciliary landscape; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Neddylation; Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER" "6" "0" "1.068" "1.052" "1.000" "1.028" "1.059" "0.990" "1.080" "1.054" "1.015" "493.7" "527.2" "519.6" "493.8" "507.3" "522.9" "488.9" "533.2" "520.2" "501.3" "" "" "" "" "" "" "" "" "" "" "462.6" "436.3" "482.4" "381.8" "432.4" "499.6" "446.7" "473.5" "520.2" "482.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7674938862773320945" "False" "High" "IsMasterProtein" "A3KMH1" "von Willebrand factor A domain-containing protein 8 OS=Homo sapiens OX=9606 GN=VWA8 PE=1 SV=2" "0.000" "False" "22.654" "5" "9" "10" "9" "1905" "214.7" "7.40" "25.58" "9" "" "mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07728" "23078" "ENSG00000102763" "VWA8" "A3KMH1; hsa:23078; O60310; Q5JTP6; Q5VW08; Q7Z6I9; Q86YC9; Q8N3E4" "" "" "0" "0" "0.963" "0.971" "1.030" "1.074" "0.995" "0.995" "0.979" "0.947" "1.007" "531.6" "511.8" "516.3" "547.8" "570.8" "529.0" "528.9" "520.4" "503.5" "535.5" "" "" "" "" "" "" "" "" "" "" "498.1" "423.5" "479.3" "423.4" "486.6" "505.4" "483.3" "462.1" "503.5" "515.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5208446995115017732" "False" "High" "IsMasterProtein" "Q5TFE4" "5'-nucleotidase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NT5DC1 PE=1 SV=1" "0.000" "False" "22.642" "20" "8" "11" "8" "455" "51.8" "6.35" "36.94" "8" "" "" "other molecular function" "Pf05761" "221294" "ENSG00000178425" "NT5DC1" "B2RND9; B3KR35; hsa:221294; Q5TFE4; Q6XYD5" "" "" "0" "0" "0.924" "0.995" "0.926" "0.934" "0.948" "0.930" "0.971" "0.985" "0.959" "1464.7" "1353.3" "1457.9" "1356.9" "1368.3" "1388.9" "1362.0" "1422.9" "1442.5" "1405.1" "" "" "" "" "" "" "" "" "" "" "1372.4" "1119.8" "1353.5" "1048.9" "1166.3" "1327.0" "1244.5" "1263.4" "1442.5" "1352.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1363881983208351205" "False" "High" "IsMasterProtein" "Q15438" "Cytohesin-1 OS=Homo sapiens OX=9606 GN=CYTH1 PE=1 SV=1" "0.000" "False" "22.627" "22" "8" "9" "8" "398" "46.4" "5.54" "30.69" "8" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01369" "9267" "ENSG00000108669" "CYTH1" "A6NFW7; B7Z1T4; hsa:9267; Q15438; Q9P123; Q9P124" "2q37 copy number variation syndrome" "Intra-Golgi traffic" "2" "0" "0.962" "0.977" "1.056" "0.947" "0.951" "0.986" "0.885" "0.938" "0.986" "952.3" "915.8" "930.8" "1006.0" "901.8" "905.3" "938.9" "842.4" "893.7" "938.5" "" "" "" "" "" "" "" "" "" "" "892.3" "757.8" "864.1" "777.7" "768.6" "865.0" "857.9" "747.9" "893.7" "903.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5588374002070682198" "False" "High" "IsMasterProtein" "P63000" "Ras-related C3 botulinum toxin substrate 1 OS=Homo sapiens OX=9606 GN=RAC1 PE=1 SV=1" "0.000" "False" "22.617" "27" "5" "12" "2" "192" "21.4" "8.50" "41.55" "5" "cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5879" "ENSG00000136238" "RAC1" "hsa:5879; O95501; P15154; P63000; Q3Y4D3; Q5JAA8; Q9BTB4" "Androgen receptor signaling pathway; Nucleotide-binding oligomerization domain (NOD) pathway; Target of rapamycin signaling; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; RalA downstream regulated genes; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; Amyotrophic lateral sclerosis (ALS); Cardiac hypertrophic response; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; Robo4 and VEGF signaling pathways crosstalk; p38 MAPK signaling pathway; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Ciliary landscape; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; Leukocyte-intrinsic Hippo pathway functions; Neural crest cell migration during development; Neural crest cell migration in cancer; Gastrin signaling pathway; Melanoma; Netrin-UNC5B signaling pathway; Insulin signaling; CAMKK2 pathway; Opioid receptor pathways; Regulation of actin cytoskeleton; GDNF signaling; 2q13 copy number variation syndrome; 2q21.1 copy number variation syndrome; 2q37 copy number variation syndrome; G13 signaling pathway; Genetic causes of porto-sinusoidal vascular disease; TROP2 regulatory signaling; 13q12.12 copy number variation; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; Interferon type I signaling pathways; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling; Neutrophil degranulation; PIP3 activates AKT signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; FCERI mediated MAPK activation; RAC1 GTPase cycle; NRAGE signals death through JNK; MAPK6/MAPK4 signaling; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; Constitutive Signaling by Aberrant PI3K in Cancer; DCC mediated attractive signaling; GPVI-mediated activation cascade; Signaling by SCF-KIT; DAP12 signaling; Ephrin signaling; Factors involved in megakaryocyte development and platelet production; RHO GTPases activate CIT; PCP/CE pathway; WNT5:FZD7-mediated leishmania damping; EPH-ephrin mediated repulsion of cells; Sema3A PAK dependent Axon repulsion; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Signal transduction by L1; RHO GTPases activate PKNs; RHO GTPases activate PAKs; DSCAM interactions; Azathioprine ADME; VEGFR2 mediated vascular permeability; Sema4D mediated inhibition of cell attachment and migration; Inactivation of CDC42 and RAC1; Activation of RAC1; CD28 dependent Vav1 pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Nef and signal transduction; RHO GTPases Activate NADPH Oxidases; NTRK2 activates RAC1; MET activates RAP1 and RAC1; Activation of RAC1 downstream of NMDARs; Activated NTRK2 signals through CDK5; RHO GTPases activate KTN1" "113" "2" "1.126" "1.061" "1.050" "1.015" "1.083" "0.940" "1.026" "1.042" "1.012" "1274.0" "1434.2" "1351.9" "1338.3" "1293.5" "1379.8" "1198.1" "1307.1" "1327.5" "1289.9" "" "" "" "" "" "" "" "" "" "" "1193.8" "1186.8" "1255.1" "1034.5" "1102.6" "1318.2" "1094.7" "1160.6" "1327.5" "1242.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9040349963704556613" "False" "High" "IsMasterProtein" "P30154" "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform OS=Homo sapiens OX=9606 GN=PPP2R1B PE=1 SV=3" "0.000" "False" "22.613" "14" "8" "11" "6" "601" "66.2" "4.94" "34.58" "8" "other biological processes" "other membranes;other cell component" "enzyme regulator activity" "Pf02985, Pf13646" "5519" "ENSG00000137713" "PPP2R1B" "A8MY67; B0YJ69; B4DGQ6; B4DK91; B4DWW5; F8W8G1; hsa:5519; O75620; P30154; Q8NHV8" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Netrin-UNC5B signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; DARPP-32 events; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; PKR-mediated signaling; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "40" "0" "1.002" "1.008" "1.063" "1.006" "1.007" "0.983" "0.958" "0.937" "1.007" "575.5" "576.4" "579.9" "612.0" "579.0" "579.5" "565.6" "551.4" "539.4" "579.5" "" "" "" "" "" "" "" "" "" "" "539.3" "477.0" "538.4" "473.1" "493.5" "553.7" "516.8" "489.6" "539.4" "557.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8157399823022384529" "False" "High" "IsMasterProtein" "Q99567" "Nuclear pore complex protein Nup88 OS=Homo sapiens OX=9606 GN=NUP88 PE=1 SV=2" "0.000" "False" "22.611" "9" "6" "9" "6" "741" "83.5" "5.69" "31.22" "6" "other metabolic processes;transport" "cytosol;nucleus" "other molecular function" "Pf10168" "4927" "ENSG00000108559" "NUP88" "D3DTM2; hsa:4927; Q99567; Q9BWE5" "Ciliary landscape" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Viral Messenger RNA Synthesis; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; tRNA processing in the nucleus; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)" "29" "0" "1.004" "1.019" "0.976" "0.968" "1.036" "0.964" "0.961" "0.966" "1.025" "1626.8" "1632.6" "1657.1" "1588.2" "1575.4" "1684.9" "1568.2" "1564.1" "1571.5" "1666.8" "" "" "" "" "" "" "" "" "" "" "1524.3" "1351.0" "1538.4" "1227.8" "1342.9" "1609.8" "1433.0" "1388.8" "1571.5" "1604.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4447457189107336251" "False" "High" "IsMasterProtein" "O60493" "Sorting nexin-3 OS=Homo sapiens OX=9606 GN=SNX3 PE=1 SV=3" "0.000" "False" "22.593" "36" "6" "15" "4" "162" "18.8" "8.66" "33.47" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787" "8724" "ENSG00000112335" "SNX3" "A8K0B1; E1P5E4; E1P5E5; hsa:8724; O60493; O60718; Q4TT29; Q4TT31; Q5JXJ7; Q5JXJ8; Q96AP9; Q9C0J5; Q9NU45" "" "Ub-specific processing proteases; WNT ligand biogenesis and trafficking" "2" "0" "1.114" "1.091" "1.050" "1.111" "1.132" "1.017" "1.062" "1.074" "1.096" "341.0" "379.8" "371.9" "358.0" "379.0" "386.1" "346.8" "362.2" "366.4" "373.9" "" "" "" "" "" "" "" "" "" "" "319.6" "314.3" "345.3" "276.8" "323.1" "368.9" "316.9" "321.6" "366.4" "360.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4208729749156870383" "False" "High" "IsMasterProtein" "O60678" "Protein arginine N-methyltransferase 3 OS=Homo sapiens OX=9606 GN=PRMT3 PE=1 SV=4" "0.000" "False" "22.586" "16" "7" "11" "7" "531" "59.9" "5.35" "30.34" "7" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;other molecular function" "Pf06325, Pf21137, Pf21336" "10196" "ENSG00000185238" "PRMT3" "A0A0A0MSN7; B4DUC7; hsa:10196; O60678" "Nitric oxide metabolism in cystic fibrosis" "RMTs methylate histone arginines; Protein methylation" "3" "0" "1.006" "1.019" "1.121" "1.030" "1.015" "1.099" "1.064" "1.008" "1.093" "192.2" "193.3" "195.8" "215.5" "197.9" "195.0" "211.2" "204.5" "193.8" "210.0" "" "" "" "" "" "" "" "" "" "" "180.1" "160.0" "181.8" "166.6" "168.7" "186.3" "193.0" "181.6" "193.8" "202.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5993686438301718268" "False" "High" "IsMasterProtein" "Q96P11" "28S rRNA (cytosine-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NSUN5 PE=1 SV=2" "0.000" "False" "22.585" "18" "8" "10" "8" "429" "46.7" "8.62" "22.98" "8" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf01189, Pf21148, Pf21153" "55695" "ENSG00000130305" "NSUN5" "B3KX04; B4DP79; G3V0G9; hsa:55695; Q6ZUI8; Q96HT9; Q96P11; Q9NW70" "" "" "0" "0" "1.034" "1.083" "1.034" "1.100" "1.094" "1.039" "1.129" "1.131" "1.062" "993.0" "1026.8" "1075.5" "1026.6" "1092.8" "1086.1" "1031.7" "1121.1" "1122.9" "1054.2" "" "" "" "" "" "" "" "" "" "" "930.5" "849.6" "998.5" "793.6" "931.4" "1037.6" "942.7" "995.4" "1122.9" "1015.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5641944312381893453" "False" "High" "IsMasterProtein" "Q8IYB7" "DIS3-like exonuclease 2 OS=Homo sapiens OX=9606 GN=DIS3L2 PE=1 SV=4" "0.000" "False" "22.576" "10" "10" "11" "10" "885" "99.2" "6.10" "26.35" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00773, Pf17216, Pf17849, Pf17877" "129563" "ENSG00000144535" "DIS3L2" "hsa:129563; Q53S79; Q580W6; Q5XKH0; Q69YG5; Q6AW99; Q7Z4T6; Q8IYB7; Q8N9K9" "" "Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "1" "0" "0.981" "1.055" "1.047" "0.984" "0.968" "0.988" "1.053" "0.963" "1.078" "320.7" "314.5" "338.4" "335.8" "315.6" "310.3" "316.8" "337.7" "308.8" "345.6" "" "" "" "" "" "" "" "" "" "" "300.5" "260.3" "314.2" "259.6" "269.0" "296.5" "289.4" "299.9" "308.8" "332.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "875070389354990237" "False" "High" "IsMasterProtein" "O00273" "DNA fragmentation factor subunit alpha OS=Homo sapiens OX=9606 GN=DFFA PE=1 SV=1" "0.000" "False" "22.563" "24" "7" "11" "7" "331" "36.5" "4.79" "36.68" "7" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02017, Pf09033" "1676" "ENSG00000160049" "DFFA" "hsa:1676; O00273; Q5T6G5; Q5T6G6; Q96I97; Q9Y6C6" "Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis" "Apoptosis induced DNA fragmentation" "4" "0" "0.962" "0.967" "0.993" "1.011" "1.001" "1.011" "1.032" "0.981" "1.000" "1351.7" "1300.3" "1307.3" "1342.8" "1366.4" "1353.2" "1367.0" "1395.6" "1325.5" "1351.4" "" "" "" "" "" "" "" "" "" "" "1266.6" "1076.0" "1213.6" "1038.1" "1164.7" "1292.8" "1249.0" "1239.2" "1325.5" "1301.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8563010740913614584" "False" "High" "IsMasterProtein" "Q96EB6" "NAD-dependent protein deacetylase sirtuin-1 OS=Homo sapiens OX=9606 GN=SIRT1 PE=1 SV=2" "0.000" "False" "22.560" "10" "8" "11" "8" "747" "81.6" "4.67" "33.55" "8" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02146" "23411" "ENSG00000096717" "SIRT1" "hsa:23411; Q2XNF6; Q5JVQ0; Q96EB6; Q9GZR9; Q9Y6F0" "Androgen receptor signaling pathway; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Melatonin metabolism and effects; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Interactions between LOXL4 and oxidative stress pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Caloric restriction and aging; CAMKK2 pathway; 3q29 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Inclusion body myositis; Prostaglandin and leukotriene metabolism in senescence ; DYRK1A involvement regarding cell proliferation in brain development; Primary ovarian insufficiency; Prostaglandin and leukotriene metabolism in senescence ; 10q11.21q11.23 copy number variation syndrome; TAR syndrome; Omega-6-fatty acids in senescence" "SIRT1 negatively regulates rRNA expression; Regulation of HSF1-mediated heat shock response; Heme signaling; Circadian Clock; Regulation of FOXO transcriptional activity by acetylation" "27" "0" "0.933" "0.912" "0.967" "0.941" "0.989" "0.951" "0.949" "0.927" "0.974" "565.6" "527.6" "515.9" "547.2" "532.0" "559.4" "538.0" "536.6" "524.4" "550.9" "" "" "" "" "" "" "" "" "" "" "530.0" "436.6" "478.9" "423.0" "453.5" "534.4" "491.6" "476.5" "524.4" "530.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5638474282161267402" "False" "High" "IsMasterProtein" "Q969Z0" "FAST kinase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=TBRG4 PE=1 SV=1" "0.000" "False" "22.555" "12" "8" "12" "8" "631" "70.7" "7.42" "33.63" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "" "Pf06743, Pf08368, Pf08373" "9238" "ENSG00000136270" "TBRG4" "A4D2L2; A4D2L3; D3DVL5; D3DVL6; hsa:9238; O14710; Q53GI8; Q8NDM4; Q969Z0; Q9BUC6; Q9Y2F6" "" "FASTK family proteins regulate processing and stability of mitochondrial RNAs" "1" "0" "0.995" "1.072" "0.968" "1.005" "1.060" "0.987" "1.003" "1.049" "1.053" "1464.2" "1456.4" "1570.3" "1418.0" "1471.6" "1552.8" "1445.6" "1468.9" "1536.3" "1541.2" "" "" "" "" "" "" "" "" "" "" "1372.0" "1205.2" "1457.8" "1096.2" "1254.4" "1483.6" "1320.9" "1304.2" "1536.3" "1483.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6083245125138804483" "False" "High" "IsMasterProtein" "Q15027" "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ACAP1 PE=1 SV=1" "0.000" "False" "22.535" "13" "8" "10" "8" "740" "81.5" "7.66" "31.38" "8" "transport" "other membranes;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00023, Pf00169, Pf01412, Pf16746" "9744" "ENSG00000072818; ENSG00000288169" "ACAP1" "hsa:9744; Q15027; Q53XN9" "Nucleotide-binding oligomerization domain (NOD) pathway" "" "1" "0" "1.073" "1.035" "1.084" "1.024" "1.038" "1.011" "0.975" "0.997" "1.070" "542.2" "581.9" "561.4" "587.9" "555.0" "562.8" "548.0" "528.8" "540.4" "580.1" "" "" "" "" "" "" "" "" "" "" "508.1" "481.5" "521.2" "454.5" "473.1" "537.7" "500.7" "469.5" "540.4" "558.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5858537743821975597" "False" "High" "IsMasterProtein" "O75843" "AP-1 complex subunit gamma-like 2 OS=Homo sapiens OX=9606 GN=AP1G2 PE=1 SV=1" "0.000" "False" "22.534" "8" "7" "9" "6" "785" "87.1" "6.55" "28.08" "7" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf01602, Pf02883" "8906" "ENSG00000213983" "AP1G2" "D3DS51; hsa:8906; O75504; O75843" "" "Lysosome Vesicle Biogenesis" "1" "0" "1.087" "1.057" "1.109" "1.107" "1.114" "1.064" "1.006" "1.042" "1.043" "735.1" "798.7" "777.0" "814.8" "813.3" "818.8" "782.3" "739.4" "766.1" "767.0" "" "" "" "" "" "" "" "" "" "" "688.8" "660.9" "721.3" "629.9" "693.3" "782.3" "714.8" "656.5" "766.1" "738.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1845786618234347704" "False" "High" "IsMasterProtein" "P55263" "Adenosine kinase OS=Homo sapiens OX=9606 GN=ADK PE=1 SV=2" "0.000" "False" "22.532" "24" "9" "14" "9" "362" "40.5" "6.70" "43.43" "9" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus" "kinase activity;other molecular function" "Pf00294" "132" "ENSG00000156110" "ADK" "B7Z783; B7Z800; hsa:132; O00741; O00742; P55263; Q16710; Q5JQ10; Q5JQ11; Q9BTN2" "Methionine metabolism leading to sulfur amino acids and related disorders" "Ribavirin ADME; Purine salvage" "3" "0" "1.146" "1.014" "0.993" "1.019" "1.063" "0.941" "1.014" "1.090" "1.002" "1663.4" "1907.1" "1687.0" "1652.6" "1695.6" "1768.3" "1565.4" "1686.7" "1812.5" "1666.1" "" "" "" "" "" "" "" "" "" "" "1558.6" "1578.1" "1566.2" "1277.5" "1445.3" "1689.5" "1430.4" "1497.6" "1812.5" "1604.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5898955459380036323" "False" "High" "IsMasterProtein" "Q05048" "Cleavage stimulation factor subunit 1 OS=Homo sapiens OX=9606 GN=CSTF1 PE=1 SV=1" "0.000" "False" "22.515" "21" "8" "9" "8" "431" "48.3" "6.58" "33.51" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00400, Pf16699" "1477" "ENSG00000101138" "CSTF1" "hsa:1477; Q05048; Q5QPD8" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "0.754" "0.748" "0.780" "0.784" "1.058" "0.800" "0.848" "0.854" "0.787" "2110.1" "1591.4" "1578.1" "1645.6" "1654.9" "2232.6" "1688.6" "1788.9" "1801.2" "1661.7" "" "" "" "" "" "" "" "" "" "" "1977.2" "1316.9" "1465.0" "1272.1" "1410.6" "2133.0" "1542.9" "1588.4" "1801.2" "1600.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1635726356787300158" "False" "High" "IsMasterProtein" "Q7LDG7" "RAS guanyl-releasing protein 2 OS=Homo sapiens OX=9606 GN=RASGRP2 PE=1 SV=1" "0.000" "False" "22.505" "11" "8" "10" "8" "609" "69.2" "7.80" "30.69" "8" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00130, Pf00617, Pf00618, Pf13202" "10235" "ENSG00000068831" "RASGRP2" "A6NDC7; hsa:10235; O00538; Q7LDG7; Q9UL65" "MAPK signaling pathway; Chemokine signaling pathway; Ras signaling" "Integrin signaling; Rap1 signalling; FCERI mediated NF-kB activation; Effects of PIP2 hydrolysis" "7" "0" "1.025" "1.052" "1.134" "1.053" "1.066" "0.976" "1.012" "1.031" "1.047" "1284.1" "1316.3" "1350.9" "1455.9" "1352.4" "1368.4" "1253.4" "1299.9" "1323.6" "1344.2" "" "" "" "" "" "" "" "" "" "" "1203.2" "1089.2" "1254.1" "1125.5" "1152.8" "1307.4" "1145.3" "1154.2" "1323.6" "1294.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-994823259514569156" "False" "High" "IsMasterProtein" "Q96I59" "Asparaginyl-tRNA synthetase OS=Homo sapiens OX=9606 GN=NARS2 PE=1 SV=3" "0.000" "False" "22.483" "18" "9" "15" "9" "477" "54.1" "7.24" "39.51" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336" "79731" "ENSG00000137513" "NARS2" "G3V178; hsa:79731; Q96I59" "Ectoderm differentiation" "Mitochondrial tRNA aminoacylation" "2" "0" "0.982" "1.021" "1.071" "1.015" "1.016" "0.975" "0.978" "1.087" "1.005" "1085.5" "1065.7" "1108.4" "1162.5" "1102.0" "1102.5" "1057.9" "1062.0" "1180.1" "1090.6" "" "" "" "" "" "" "" "" "" "" "1017.1" "881.9" "1029.0" "898.6" "939.3" "1053.3" "966.7" "942.9" "1180.1" "1050.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1664770674535561933" "False" "High" "IsMasterProtein" "Q96T37" "RNA-binding protein 15 OS=Homo sapiens OX=9606 GN=RBM15 PE=1 SV=2" "0.000" "False" "22.476" "10" "9" "12" "9" "977" "107.1" "10.08" "34.30" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf07744" "64783" "ENSG00000162775" "RBM15" "A1A693; hsa:64783; Q3ZB86; Q4V760; Q5D058; Q5T613; Q86VW9; Q96PE4; Q96SC5; Q96SC6; Q96SC9; Q96SD0; Q96T37; Q96T38; Q9BRA5; Q9H6R8; Q9H9Y0" "" "" "0" "0" "1.238" "1.094" "1.314" "1.333" "1.159" "1.464" "1.543" "1.482" "1.240" "292.1" "361.7" "319.5" "383.9" "389.5" "338.7" "427.7" "450.8" "432.9" "362.1" "" "" "" "" "" "" "" "" "" "" "273.7" "299.3" "296.6" "296.8" "332.0" "323.6" "390.8" "400.3" "432.9" "348.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3786369172385558853" "False" "High" "IsMasterProtein" "P19388" "DNA-directed RNA polymerases I, II, and III subunit RPABC1 OS=Homo sapiens OX=9606 GN=POLR2E PE=1 SV=4" "0.000" "False" "22.475" "34" "7" "12" "7" "210" "24.5" "5.95" "29.17" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01191, Pf03871" "5434" "ENSG00000099817" "POLR2E" "B2R6L4; D6W5Y1; hsa:5434; O43380; P19388; Q6PIH5; Q9BT06" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "57" "0" "0.926" "0.964" "0.979" "0.965" "0.956" "0.978" "1.020" "0.936" "0.975" "1103.8" "1022.3" "1064.5" "1081.0" "1064.7" "1055.8" "1079.2" "1126.3" "1033.3" "1076.2" "" "" "" "" "" "" "" "" "" "" "1034.3" "845.9" "988.2" "835.7" "907.5" "1008.7" "986.1" "1000.0" "1033.3" "1036.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6418921267369266529" "False" "High" "IsMasterProtein" "P31321" "cAMP-dependent protein kinase type I-beta regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR1B PE=1 SV=4" "0.000" "False" "22.469" "22" "8" "10" "5" "381" "43.0" "5.71" "31.48" "8" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5575" "ENSG00000188191" "PRKAR1B" "hsa:5575; P31321; Q8N422" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Cannabinoid receptor signaling; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase" "21" "0" "0.996" "1.006" "1.091" "1.020" "0.959" "1.024" "0.983" "0.950" "0.985" "387.4" "386.0" "389.7" "422.5" "395.2" "371.7" "396.6" "380.7" "368.2" "381.6" "" "" "" "" "" "" "" "" "" "" "363.0" "319.4" "361.8" "326.6" "336.9" "355.1" "362.4" "338.0" "368.2" "367.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4004494409327660908" "False" "High" "IsMasterProtein" "P07205" "Phosphoglycerate kinase 2 OS=Homo sapiens OX=9606 GN=PGK2 PE=1 SV=3" "0.000" "False" "22.465" "15" "6" "14" "2" "417" "44.8" "8.54" "51.91" "6" "other metabolic processes;other biological processes" "cytosol;cytoskeleton" "kinase activity;other molecular function" "Pf00162" "5232" "ENSG00000170950" "PGK2" "B2R6Y8; hsa:5232; P07205; Q9H107" "Cori cycle; Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis" "6" "0" "1.035" "0.988" "0.941" "0.996" "1.080" "0.915" "1.026" "0.971" "0.930" "666.1" "689.4" "658.3" "627.1" "663.6" "719.6" "609.3" "683.3" "646.7" "619.5" "" "" "" "" "" "" "" "" "" "" "624.1" "570.5" "611.2" "484.8" "565.6" "687.5" "556.7" "606.7" "646.7" "596.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5840066189523461680" "False" "High" "IsMasterProtein" "P22694" "cAMP-dependent protein kinase catalytic subunit beta OS=Homo sapiens OX=9606 GN=PRKACB PE=1 SV=2" "0.000" "False" "22.464" "22" "7" "9" "3" "351" "40.6" "8.78" "30.69" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5567" "ENSG00000142875" "PRKACB" "B1APG4; B4DKB0; B4E2Q1; hsa:5567; P22694; Q14VH1; Q59GC0; Q5BNE9; Q5BNF0; Q5BNF1; Q5BNF2; Q5BNF3; Q5CZ92; Q5T1K3; Q7Z3M1; Q8IYR5; Q8IZQ0; Q96B09" "AMP-activated protein kinase signaling; Dopamine metabolism; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; G protein signaling pathways; MAPK signaling pathway; Cannabinoid receptor signaling; Chemokine signaling pathway; Lipid metabolism pathway; Ras signaling; Hedgehog signaling pathway; Thermogenesis; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; GPR143 in melanocytes and retinal pigment epithelium cells; Vasopressin-regulated water reabsorption; Cardiomyocyte signaling pathways converging on titin; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "FCGR3A-mediated IL10 synthesis; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Triglyceride catabolism; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; RET signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; CD209 (DC-SIGN) signaling; Rap1 signalling; HDL assembly; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; ROBO receptors bind AKAP5; PKA-mediated phosphorylation of key metabolic factors" "47" "3" "0.917" "0.923" "0.945" "0.988" "0.950" "0.946" "1.011" "0.970" "0.940" "1054.7" "967.1" "973.3" "996.3" "1041.6" "1001.6" "997.2" "1066.7" "1023.1" "991.2" "" "" "" "" "" "" "" "" "" "" "988.2" "800.2" "903.6" "770.2" "887.8" "956.9" "911.2" "947.1" "1023.1" "954.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3266332044031462775" "False" "High" "IsMasterProtein" "O43324" "Eukaryotic translation elongation factor 1 epsilon-1 OS=Homo sapiens OX=9606 GN=EEF1E1 PE=1 SV=1" "0.000" "False" "22.447" "32" "6" "10" "6" "174" "19.8" "8.54" "31.21" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00043" "9521" "ENSG00000124802" "EEF1E1" "C9JLK5; hsa:9521; O43324; Q5THS2" "" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "2" "0" "0.858" "0.972" "0.912" "0.936" "0.950" "0.929" "0.928" "1.014" "0.948" "1062.4" "911.9" "1032.4" "968.4" "994.7" "1009.3" "986.8" "986.0" "1076.7" "1007.3" "" "" "" "" "" "" "" "" "" "" "995.4" "754.6" "958.5" "748.6" "847.8" "964.3" "901.7" "875.5" "1076.7" "969.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "551510042259004717" "False" "High" "IsMasterProtein" "Q70J99" "Protein unc-13 homolog D OS=Homo sapiens OX=9606 GN=UNC13D PE=1 SV=1" "0.000" "False" "22.446" "8" "8" "12" "8" "1090" "123.2" "6.65" "37.81" "8" "stress response;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf06292" "201294" "ENSG00000092929" "UNC13D" "B4DWG9; hsa:201294; Q70J99; Q9H7K5" "Deregulation of Rab and Rab effector genes in bladder cancer" "Neutrophil degranulation" "2" "0" "1.038" "1.006" "1.049" "1.069" "0.972" "0.992" "0.998" "0.973" "1.016" "614.5" "638.1" "618.4" "644.7" "657.0" "597.4" "609.4" "613.5" "598.2" "624.5" "" "" "" "" "" "" "" "" "" "" "575.8" "528.0" "574.2" "498.4" "560.0" "570.8" "556.8" "544.7" "598.2" "601.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3104846382151978420" "False" "High" "IsMasterProtein" "Q9UKY7" "Protein CDV3 homolog OS=Homo sapiens OX=9606 GN=CDV3 PE=1 SV=1" "0.000" "False" "22.432" "34" "7" "10" "7" "258" "27.3" "6.40" "34.60" "7" "" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf15359" "55573" "ENSG00000091527" "CDV3" "B3KUC2; hsa:55573; Q96IP9; Q9UKY7" "" "" "0" "0" "1.006" "1.080" "0.910" "1.006" "0.901" "0.888" "0.914" "0.988" "0.937" "874.1" "879.4" "944.0" "795.7" "878.9" "787.9" "775.8" "798.9" "863.2" "819.0" "" "" "" "" "" "" "" "" "" "" "819.0" "727.7" "876.4" "615.1" "749.2" "752.8" "708.8" "709.4" "863.2" "788.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3343567279109484109" "False" "High" "IsMasterProtein" "P61326" "Protein mago nashi homolog OS=Homo sapiens OX=9606 GN=MAGOH PE=1 SV=1" "0.000" "False" "22.424" "31" "5" "11" "5" "146" "17.2" "6.11" "30.53" "5" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus" "" "Pf02792" "4116" "ENSG00000162385" "MAGOH" "B1ARP8; B2R5A2; hsa:4116; O35169; P50606; P61326; Q5SW69" "TAR syndrome" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "7" "0" "0.865" "0.972" "0.901" "0.950" "0.971" "1.039" "1.061" "1.116" "1.004" "1772.2" "1532.4" "1722.6" "1597.6" "1683.0" "1721.6" "1841.1" "1880.9" "1977.8" "1779.6" "" "" "" "" "" "" "" "" "" "" "1660.6" "1268.0" "1599.3" "1235.0" "1434.6" "1644.8" "1682.2" "1670.0" "1977.8" "1713.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1245887775356859101" "False" "High" "IsMasterProtein" "Q8N0Z6" "Tetratricopeptide repeat protein 5 OS=Homo sapiens OX=9606 GN=TTC5 PE=1 SV=2" "0.000" "False" "22.374" "19" "7" "8" "7" "440" "48.9" "6.48" "20.46" "7" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf16669" "91875" "ENSG00000136319; ENSG00000291781" "TTC5" "A8MQ18; hsa:91875; Q8N0Z6; Q96HF9" "" "Regulation of TP53 Activity through Methylation" "1" "0" "1.101" "1.114" "1.166" "1.275" "1.157" "1.107" "1.095" "1.165" "1.187" "100.7" "110.9" "112.2" "117.5" "128.4" "116.5" "111.5" "110.3" "117.3" "119.5" "" "" "" "" "" "" "" "" "" "" "94.4" "91.8" "104.1" "90.8" "109.4" "111.3" "101.9" "97.9" "117.3" "115.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7262378899326464303" "False" "High" "IsMasterProtein" "Q9BRX5" "DNA replication complex GINS protein PSF3 OS=Homo sapiens OX=9606 GN=GINS3 PE=1 SV=1" "0.000" "False" "22.363" "37" "7" "9" "7" "216" "24.5" "5.34" "31.61" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "nucleus" "" "Pf05916" "64785" "ENSG00000181938" "GINS3" "B2RDP3; E9PB21; hsa:64785; Q9BRX5; Q9H870" "" "Unwinding of DNA" "1" "0" "1.093" "1.007" "1.099" "1.101" "1.078" "1.016" "1.064" "1.070" "1.009" "880.2" "962.1" "886.3" "967.1" "968.8" "949.0" "894.1" "936.9" "942.0" "887.8" "" "" "" "" "" "" "" "" "" "" "824.7" "796.1" "822.8" "747.6" "825.8" "906.7" "817.0" "831.9" "942.0" "854.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3211102690049465357" "False" "High" "IsMasterProtein" "P11310" "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADM PE=1 SV=1" "0.000" "False" "22.345" "18" "7" "10" "7" "421" "46.6" "8.37" "40.92" "7" "other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00441, Pf02770, Pf02771" "34" "ENSG00000117054" "ACADM" "hsa:34; P11310; Q5T4U4; Q9NYF1" "Fatty acid beta-oxidation; PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; Amino acid metabolism; PPAR signaling pathway; Mitochondrial fatty acid oxidation disorders; Female steroid hormones in cardiomyocyte energy metabolism; Sudden infant death syndrome (SIDS) susceptibility pathways" "PPARA activates gene expression; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA" "13" "0" "0.995" "1.017" "0.888" "0.955" "1.058" "0.911" "0.969" "1.002" "0.958" "1230.8" "1224.8" "1251.2" "1092.9" "1175.9" "1301.8" "1120.7" "1192.8" "1233.7" "1179.2" "" "" "" "" "" "" "" "" "" "" "1153.3" "1013.5" "1161.5" "844.9" "1002.3" "1243.8" "1024.0" "1059.1" "1233.7" "1135.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8858852225098701208" "False" "High" "IsMasterProtein" "P49642" "DNA primase small subunit OS=Homo sapiens OX=9606 GN=PRIM1 PE=1 SV=1" "0.000" "False" "22.337" "17" "8" "12" "8" "420" "49.9" "8.21" "32.90" "8" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf01896" "5557" "ENSG00000198056" "PRIM1" "hsa:5557; P49642" "Retinoblastoma gene in cancer; Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Activation of the pre-replicative complex; Defective pyroptosis; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Telomere C-strand synthesis initiation; DNA replication initiation" "13" "0" "0.931" "0.983" "0.950" "0.956" "0.975" "0.913" "0.927" "0.968" "0.983" "2261.5" "2104.7" "2222.6" "2147.4" "2163.1" "2204.5" "2064.4" "2095.6" "2190.2" "2222.6" "" "" "" "" "" "" "" "" "" "" "2119.0" "1741.6" "2063.4" "1660.1" "1843.8" "2106.2" "1886.4" "1860.7" "2190.2" "2140.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5077095867447308247" "False" "High" "IsMasterProtein" "Q9BY77" "Polymerase delta-interacting protein 3 OS=Homo sapiens OX=9606 GN=POLDIP3 PE=1 SV=2" "0.000" "False" "22.336" "24" "8" "9" "8" "421" "46.1" "9.99" "25.75" "8" "other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "84271" "ENSG00000100227" "POLDIP3" "A8K6F8; A8K6V9; hsa:84271; Q009A7; Q5H972; Q6PGN6; Q7Z6Z0; Q9BY77; Q9NSP5; Q9NSP6" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "3" "0" "1.038" "1.016" "1.077" "1.099" "1.106" "1.034" "1.072" "1.046" "1.043" "544.6" "565.5" "553.0" "586.5" "598.6" "602.1" "563.2" "583.7" "569.5" "567.9" "" "" "" "" "" "" "" "" "" "" "510.2" "467.9" "513.4" "453.4" "510.2" "575.2" "514.6" "518.3" "569.5" "546.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9216601272429108085" "False" "High" "IsMasterProtein" "Q96GX9" "Methylthioribulose-1-phosphate dehydratase OS=Homo sapiens OX=9606 GN=APIP PE=1 SV=1" "0.000" "False" "22.320" "31" "7" "11" "7" "242" "27.1" "7.12" "31.71" "7" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00596" "51074" "ENSG00000149089" "APIP" "A8K9D3; hsa:51074; Q6PJX6; Q8WVU2; Q96GX9; Q96HK2; Q9Y318" "Methionine de novo and salvage pathway" "Regulation of the apoptosome activity; Methionine salvage pathway" "4" "0" "0.923" "0.940" "1.027" "0.943" "0.985" "1.019" "0.969" "0.929" "0.971" "568.7" "524.7" "534.7" "584.3" "536.0" "560.0" "579.5" "551.1" "528.4" "552.1" "" "" "" "" "" "" "" "" "" "" "532.8" "434.1" "496.4" "451.7" "456.9" "535.0" "529.5" "489.3" "528.4" "531.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3157784244312675539" "False" "High" "IsMasterProtein" "Q9UKD2" "mRNA turnover protein 4 homolog OS=Homo sapiens OX=9606 GN=MRTO4 PE=1 SV=2" "0.000" "False" "22.310" "31" "8" "9" "8" "239" "27.5" "8.29" "19.92" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00466, Pf17777" "51154" "ENSG00000053372" "MRTO4" "B3KNB3; hsa:51154; Q5TG55; Q96SS6; Q9BPV9; Q9UKD2" "" "" "0" "0" "1.038" "1.096" "1.120" "1.141" "1.049" "1.195" "1.292" "1.565" "1.080" "555.6" "576.8" "608.7" "622.2" "633.8" "582.6" "664.0" "717.8" "869.7" "599.8" "" "" "" "" "" "" "" "" "" "" "520.6" "477.3" "565.1" "481.0" "540.3" "556.6" "606.7" "637.3" "869.7" "577.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3668121595413898342" "False" "High" "IsMasterProtein" "Q96D46" "60S ribosomal export protein NMD3 OS=Homo sapiens OX=9606 GN=NMD3 PE=1 SV=1" "0.000" "False" "22.249" "15" "8" "10" "8" "503" "57.6" "7.14" "26.76" "8" "transport;other biological processes" "nucleus;other cell component" "translation activity;other molecular function" "Pf04981, Pf21192, Pf21193" "51068" "ENSG00000169251" "NMD3" "D3DNM7; hsa:51068; Q96D46; Q9Y2Z6" "" "" "0" "0" "0.979" "1.022" "1.038" "1.081" "1.074" "1.015" "1.066" "1.033" "1.024" "1043.2" "1021.0" "1066.0" "1083.2" "1127.4" "1120.6" "1058.8" "1112.3" "1077.3" "1068.1" "" "" "" "" "" "" "" "" "" "" "977.4" "844.9" "989.7" "837.3" "961.0" "1070.6" "967.5" "987.6" "1077.3" "1028.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1178646061152564690" "False" "High" "IsMasterProtein" "P40938" "Replication factor C subunit 3 OS=Homo sapiens OX=9606 GN=RFC3 PE=1 SV=2" "0.000" "False" "22.234" "17" "6" "9" "6" "356" "40.5" "8.34" "29.74" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13177" "5983" "ENSG00000133119" "RFC3" "C9JU95; hsa:5983; O15252; P40938; Q5W0E8" "Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "PCNA-Dependent Long Patch Base Excision Repair; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "28" "0" "0.988" "0.971" "1.051" "1.066" "0.955" "0.876" "1.016" "1.023" "1.010" "366.7" "362.3" "355.9" "385.4" "391.0" "350.0" "321.1" "372.6" "375.2" "370.5" "" "" "" "" "" "" "" "" "" "" "343.6" "299.8" "330.4" "297.9" "333.3" "334.4" "293.4" "330.9" "375.2" "356.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3767865638315377274" "False" "High" "IsMasterProtein" "O60684" "Importin subunit alpha-7 OS=Homo sapiens OX=9606 GN=KPNA6 PE=1 SV=1" "0.000" "False" "22.226" "16" "8" "9" "7" "536" "60.0" "4.98" "31.86" "8" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "23633" "ENSG00000025800" "KPNA6" "B2RDC7; D3DPP5; hsa:23633; O60684; Q5VVU3" "" "Assembly of the ORC complex at the origin of replication" "1" "1" "1.019" "1.047" "1.096" "1.045" "1.005" "1.055" "0.982" "0.970" "1.047" "1301.4" "1326.5" "1362.0" "1425.7" "1360.4" "1308.1" "1373.1" "1278.3" "1262.9" "1362.8" "" "" "" "" "" "" "" "" "" "" "1219.4" "1097.7" "1264.4" "1102.2" "1159.6" "1249.7" "1254.6" "1135.0" "1262.9" "1312.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6922732359213996073" "False" "High" "IsMasterProtein" "Q9H4L7" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 OS=Homo sapiens OX=9606 GN=SMARCAD1 PE=1 SV=2" "0.000" "False" "22.214" "9" "9" "9" "9" "1026" "117.3" "5.55" "29.67" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "56916" "ENSG00000163104" "SMARCAD1" "B7Z799; hsa:56916; Q05D56; Q96SX1; Q9H017; Q9H4L7; Q9H860; Q9NPU9; Q9ULU7" "" "" "0" "0" "0.956" "1.029" "0.945" "1.035" "1.016" "1.045" "1.022" "1.027" "1.036" "847.1" "809.8" "871.6" "800.1" "877.1" "860.6" "885.1" "865.6" "869.8" "877.3" "" "" "" "" "" "" "" "" "" "" "793.7" "670.1" "809.2" "618.5" "747.6" "822.2" "808.7" "768.5" "869.8" "844.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9023390433505774979" "False" "High" "IsMasterProtein" "P53597" "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG1 PE=1 SV=4" "0.000" "False" "22.203" "20" "6" "10" "6" "346" "36.2" "8.79" "32.06" "6" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00549, Pf02629" "8802" "ENSG00000163541" "SUCLG1" "hsa:8802; P53597; Q9BWB0; Q9UNP6" "Amino acid metabolism; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle)" "3" "0" "0.977" "1.022" "0.929" "0.973" "0.987" "0.986" "0.998" "1.017" "0.984" "1553.7" "1518.5" "1587.2" "1443.1" "1511.2" "1533.3" "1531.8" "1550.9" "1580.6" "1528.6" "" "" "" "" "" "" "" "" "" "" "1455.8" "1256.6" "1473.5" "1115.6" "1288.1" "1464.9" "1399.7" "1377.0" "1580.6" "1471.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8293533738236197165" "False" "High" "IsMasterProtein" "O75347" "Tubulin-specific chaperone A OS=Homo sapiens OX=9606 GN=TBCA PE=1 SV=3" "0.000" "False" "22.190" "50" "7" "13" "7" "108" "12.8" "5.29" "35.32" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02970" "6902" "ENSG00000171530" "TBCA" "B4DT30; hsa:6902; O75347" "VEGFA-VEGFR2 signaling" "Post-chaperonin tubulin folding pathway" "2" "0" "1.076" "0.931" "0.998" "0.958" "0.994" "0.922" "1.028" "0.863" "0.991" "1725.3" "1855.8" "1606.5" "1721.5" "1653.3" "1714.1" "1590.8" "1773.7" "1489.7" "1709.5" "" "" "" "" "" "" "" "" "" "" "1616.6" "1535.6" "1491.5" "1330.8" "1409.3" "1637.7" "1453.6" "1574.8" "1489.7" "1646.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-911764670660096816" "False" "High" "IsMasterProtein" "P08195" "Amino acid transporter heavy chain SLC3A2 OS=Homo sapiens OX=9606 GN=SLC3A2 PE=1 SV=3" "0.000" "False" "22.190" "13" "7" "7" "7" "630" "68.0" "5.01" "20.81" "7" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;nucleic acid binding activity;other molecular function" "Pf00128, Pf16028" "6520" "ENSG00000168003" "SLC3A2" "hsa:6520; J3KPF3; P08195; Q13543" "mRNA, protein, and metabolite inducation pathway by cyclosporin A; Ferroptosis; Proximal tubule transport; Pleural mesothelioma" "Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane; Defective SLC7A7 causes lysinuric protein intolerance (LPI)" "8" "0" "1.036" "0.973" "0.989" "0.999" "1.039" "0.957" "0.957" "0.953" "1.038" "331.4" "343.2" "322.3" "327.9" "331.2" "344.2" "317.3" "317.2" "315.7" "344.1" "" "" "" "" "" "" "" "" "" "" "310.5" "284.0" "299.2" "253.5" "282.3" "328.9" "289.9" "281.7" "315.7" "331.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5034217840069919209" "False" "High" "IsMasterProtein" "O95721" "Synaptosomal-associated protein 29 OS=Homo sapiens OX=9606 GN=SNAP29 PE=1 SV=1" "0.000" "False" "22.141" "26" "8" "9" "8" "258" "29.0" "5.81" "32.14" "8" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "" "9342" "ENSG00000099940" "SNAP29" "hsa:9342; O95721" "Ciliary landscape; 22q11.2 copy number variation syndrome" "Intra-Golgi traffic; Neutrophil degranulation" "4" "0" "1.129" "1.002" "1.113" "1.068" "1.037" "1.068" "1.004" "1.003" "1.025" "721.9" "815.1" "723.6" "803.2" "771.2" "748.6" "770.7" "724.8" "723.9" "739.8" "" "" "" "" "" "" "" "" "" "" "676.4" "674.5" "671.8" "620.9" "657.4" "715.2" "704.3" "643.6" "723.9" "712.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4286201540320348411" "False" "High" "IsMasterProtein" "Q92990" "Glomulin OS=Homo sapiens OX=9606 GN=GLMN PE=1 SV=2" "0.000" "False" "22.103" "12" "8" "9" "8" "594" "68.2" "5.33" "25.16" "8" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf08568" "11146" "ENSG00000174842" "GLMN" "hsa:11146; Q5VVC3; Q92990; Q9BVE8" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.962" "0.957" "0.910" "0.955" "0.946" "0.896" "0.924" "0.973" "0.944" "1160.3" "1115.7" "1110.4" "1056.1" "1107.9" "1097.8" "1040.2" "1072.4" "1129.0" "1095.2" "" "" "" "" "" "" "" "" "" "" "1087.2" "923.2" "1030.9" "816.4" "944.3" "1048.8" "950.4" "952.2" "1129.0" "1054.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1560013588739463450" "False" "High" "IsMasterProtein" "Q9H7D7" "WD repeat-containing protein 26 OS=Homo sapiens OX=9606 GN=WDR26 PE=1 SV=3" "0.000" "False" "22.078" "10" "8" "10" "8" "661" "72.1" "6.16" "29.01" "8" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf00400, Pf17814" "80232" "ENSG00000162923" "WDR26" "A0MNN3; hsa:80232; Q4G100; Q59EC4; Q5GLZ9; Q86UY4; Q9H3C2; Q9H7D7" "Ciliary landscape" "" "1" "0" "0.996" "0.984" "0.970" "0.987" "0.981" "0.987" "0.974" "1.004" "1.001" "988.9" "984.6" "973.0" "958.9" "976.2" "970.3" "975.8" "963.2" "993.2" "990.3" "" "" "" "" "" "" "" "" "" "" "926.6" "814.7" "903.3" "741.3" "832.1" "927.0" "891.6" "855.3" "993.2" "953.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2238397026184103268" "False" "High" "IsMasterProtein" "Q9ULU4" "MYND-type zinc finger-containing chromatin reader ZMYND8 OS=Homo sapiens OX=9606 GN=ZMYND8 PE=1 SV=2" "0.000" "False" "22.064" "7" "8" "8" "8" "1186" "131.6" "7.20" "26.66" "8" "cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00439, Pf00628, Pf00855, Pf12064" "23613" "ENSG00000101040" "ZMYND8" "B3KVL2; B7Z2A8; B7Z3E0; B7Z680; B7ZM62; E1P5U5; F5H0X3; H7C0U2; hsa:23613; J3KPU3; Q13517; Q2HXV1; Q2HXV2; Q2HXV3; Q2HXV4; Q2HXV7; Q2HXV8; Q2HXV9; Q2HXW0; Q2HXW1; Q2HXW2; Q4JJ94; Q4JJ95; Q5TH09; Q5TH11; Q6MZM1; Q8WXC5; Q9H1F3; Q9H1F4; Q9H1F5; Q9H1L8; Q9H1L9; Q9H2G5; Q9NYN3; Q9UIX6; Q9ULU4" "" "" "0" "0" "1.058" "1.129" "1.066" "1.006" "1.039" "1.275" "1.180" "1.168" "1.107" "580.3" "614.0" "654.9" "618.8" "583.6" "603.2" "739.6" "684.9" "678.0" "642.5" "" "" "" "" "" "" "" "" "" "" "543.7" "508.1" "608.0" "478.4" "497.5" "576.3" "675.8" "608.1" "678.0" "618.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7463755477932393031" "False" "High" "IsMasterProtein" "Q9H4M9" "EH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=EHD1 PE=1 SV=2" "0.000" "False" "22.063" "16" "8" "10" "8" "534" "60.6" "6.83" "25.79" "8" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00350, Pf12763, Pf16880, Pf18150" "10938" "ENSG00000110047" "EHD1" "hsa:10938; O14611; Q2M3Q4; Q9H4M9; Q9UNR3" "Insulin signaling" "Factors involved in megakaryocyte development and platelet production" "2" "0" "0.984" "1.098" "0.925" "0.966" "1.058" "0.856" "1.008" "1.064" "1.018" "412.1" "405.6" "452.6" "381.2" "398.0" "436.0" "352.9" "415.2" "438.3" "419.7" "" "" "" "" "" "" "" "" "" "" "386.1" "335.6" "420.2" "294.7" "339.2" "416.5" "322.5" "368.7" "438.3" "404.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2699158399968223668" "False" "High" "IsMasterProtein" "Q15311" "RalA-binding protein 1 OS=Homo sapiens OX=9606 GN=RALBP1 PE=1 SV=3" "0.000" "False" "22.062" "12" "8" "9" "8" "655" "76.0" "5.88" "25.22" "8" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus" "transporter activity;enzyme regulator activity;other molecular function" "Pf00620, Pf20924" "10928" "ENSG00000017797" "RALBP1" "D3DUI0; hsa:10928; Q15311" "RalA downstream regulated genes; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "CDC42 GTPase cycle; RAC1 GTPase cycle" "6" "0" "0.963" "0.948" "0.995" "1.030" "0.976" "0.982" "1.000" "0.988" "0.994" "944.5" "909.5" "895.2" "939.6" "973.1" "921.6" "927.8" "944.6" "932.9" "938.5" "" "" "" "" "" "" "" "" "" "" "885.0" "752.6" "831.1" "726.3" "829.5" "880.5" "847.7" "838.7" "932.9" "903.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9201428938326541883" "False" "High" "IsMasterProtein" "Q15291" "Retinoblastoma-binding protein 5 OS=Homo sapiens OX=9606 GN=RBBP5 PE=1 SV=2" "0.000" "False" "22.019" "14" "8" "10" "8" "538" "59.1" "5.10" "26.48" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00400" "5929" "ENSG00000117222" "RBBP5" "A8K272; hsa:5929; Q15291; Q7Z6D8; Q8NDZ7" "Kleefstra syndrome" "Neddylation; Formation of WDR5-containing histone-modifying complexes; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "8" "0" "0.984" "0.978" "0.978" "1.061" "0.964" "0.962" "1.000" "0.976" "1.047" "1569.5" "1545.1" "1534.4" "1535.7" "1665.2" "1512.6" "1510.1" "1569.6" "1531.2" "1643.5" "" "" "" "" "" "" "" "" "" "" "1470.6" "1278.5" "1424.5" "1187.1" "1419.4" "1445.1" "1379.9" "1393.7" "1531.2" "1582.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6604733771635373365" "False" "High" "IsMasterProtein" "P84085" "ADP-ribosylation factor 5 OS=Homo sapiens OX=9606 GN=ARF5 PE=1 SV=2" "0.000" "False" "22.017" "38" "6" "12" "3" "180" "20.5" "6.79" "38.47" "6" "transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00025" "381" "ENSG00000004059" "ARF5" "hsa:381; P26437; P84085" "2q37 copy number variation syndrome" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "3" "3" "0.985" "0.991" "1.074" "0.979" "1.099" "1.026" "0.988" "1.023" "0.989" "1242.4" "1223.9" "1231.4" "1334.5" "1216.0" "1364.9" "1275.3" "1228.1" "1271.4" "1229.3" "" "" "" "" "" "" "" "" "" "" "1164.2" "1012.8" "1143.2" "1031.6" "1036.5" "1304.0" "1165.3" "1090.4" "1271.4" "1183.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1870726190365747871" "False" "High" "IsMasterProtein" "P61160" "Actin-related protein 2 OS=Homo sapiens OX=9606 GN=ACTR2 PE=1 SV=1" "0.000" "False" "22.015" "22" "7" "13" "7" "394" "44.7" "6.74" "37.17" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "10097" "ENSG00000138071" "ACTR2" "B2RCP5; D6W5F4; E9PF41; hsa:10097; O15142; P61160; Q96C82" "Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways" "Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; EPHB-mediated forward signaling" "8" "0" "1.005" "1.029" "0.997" "0.952" "0.953" "0.980" "0.997" "0.929" "0.946" "1170.0" "1175.8" "1204.4" "1166.4" "1114.4" "1114.9" "1147.2" "1166.8" "1087.3" "1106.8" "" "" "" "" "" "" "" "" "" "" "1096.3" "973.0" "1118.1" "901.6" "949.9" "1065.2" "1048.2" "1036.0" "1087.3" "1065.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8897927759308668761" "False" "High" "IsMasterProtein" "Q3KQV9" "UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 OS=Homo sapiens OX=9606 GN=UAP1L1 PE=1 SV=2" "0.000" "False" "22.005" "16" "8" "14" "6" "507" "57.0" "6.32" "42.47" "8" "other metabolic processes" "" "other molecular function" "Pf01704" "91373" "ENSG00000197355" "UAP1L1" "A2AMJ8; hsa:91373; Q3KQV9; Q5SPZ2; Q69YQ3; Q6ZR38" "" "" "0" "0" "1.025" "0.969" "1.252" "1.094" "0.998" "1.114" "0.908" "0.987" "0.967" "229.6" "235.5" "222.6" "287.4" "251.2" "229.1" "255.9" "208.6" "226.6" "222.2" "" "" "" "" "" "" "" "" "" "" "215.2" "194.8" "206.6" "222.2" "214.1" "218.9" "233.8" "185.2" "226.6" "213.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3211480978683405727" "False" "High" "IsMasterProtein" "O95232" "Luc7-like protein 3 OS=Homo sapiens OX=9606 GN=LUC7L3 PE=1 SV=2" "0.000" "False" "22.001" "19" "9" "11" "9" "432" "51.4" "9.79" "32.46" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf03194" "51747" "ENSG00000108848" "LUC7L3" "B3KN54; D3DTY1; hsa:51747; O95232; Q6PHR9; Q9NUY0; Q9P2S7" "" "mRNA Splicing - Major Pathway" "1" "0" "1.039" "1.086" "0.992" "0.942" "0.985" "1.001" "0.932" "0.934" "0.946" "1120.9" "1164.3" "1216.9" "1112.4" "1055.8" "1103.5" "1121.6" "1045.0" "1047.4" "1059.9" "" "" "" "" "" "" "" "" "" "" "1050.3" "963.4" "1129.7" "860.0" "900.0" "1054.3" "1024.8" "927.8" "1047.4" "1020.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8178776459123092866" "False" "High" "IsMasterProtein" "P05387" "Large ribosomal subunit protein P2 OS=Homo sapiens OX=9606 GN=RPLP2 PE=1 SV=1" "0.000" "False" "21.993" "46" "6" "9" "6" "115" "11.7" "4.54" "35.98" "6" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00428" "6181" "ENSG00000177600" "RPLP2" "hsa:6181; P05387; Q6FG96" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins; Opioid receptor pathways" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "16" "0" "1.143" "1.064" "1.118" "1.229" "1.233" "1.399" "1.516" "1.271" "1.187" "901.2" "1030.2" "959.2" "1007.3" "1107.2" "1110.7" "1260.3" "1366.4" "1145.2" "1069.5" "" "" "" "" "" "" "" "" "" "" "844.4" "852.5" "890.5" "778.7" "943.8" "1061.2" "1151.6" "1213.2" "1145.2" "1029.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8347343991909543181" "False" "High" "IsMasterProtein" "P48200" "Iron-responsive element-binding protein 2 OS=Homo sapiens OX=9606 GN=IREB2 PE=1 SV=4" "0.000" "False" "21.987" "7" "8" "9" "8" "963" "105.0" "7.05" "27.33" "8" "other metabolic processes;transport;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00330, Pf00694" "3658" "ENSG00000136381" "IREB2" "A0A0A6YY96; A8KAC7; E1CJT9; H0YKU0; hsa:3658; P48200; Q13095; Q1HE21; Q59FQ7; Q8WVK6; Q9UF17" "Iron metabolism in placenta; Ferroptosis" "Iron uptake and transport" "3" "0" "0.910" "0.985" "0.919" "0.923" "0.932" "0.837" "0.930" "0.901" "0.938" "1049.6" "955.6" "1034.3" "964.1" "968.8" "978.7" "878.8" "975.6" "946.1" "984.5" "" "" "" "" "" "" "" "" "" "" "983.5" "790.7" "960.2" "745.3" "825.8" "935.0" "802.9" "866.2" "946.1" "947.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2320563030437256339" "False" "High" "IsMasterProtein" "Q5RKV6" "Exosome complex component MTR3 OS=Homo sapiens OX=9606 GN=EXOSC6 PE=1 SV=1" "0.000" "False" "21.964" "28" "6" "6" "6" "272" "28.2" "6.28" "27.04" "6" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf01138" "118460" "ENSG00000223496" "EXOSC6" "hsa:118460; Q5RKV6" "" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "0.970" "0.957" "0.991" "1.013" "0.990" "0.912" "1.021" "1.018" "0.954" "1102.2" "1069.3" "1054.9" "1091.8" "1116.9" "1090.7" "1005.2" "1125.2" "1122.4" "1051.2" "" "" "" "" "" "" "" "" "" "" "1032.8" "884.9" "979.3" "844.0" "952.1" "1042.1" "918.5" "999.1" "1122.4" "1012.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2413702222549115072" "False" "High" "IsMasterProtein" "P13693" "Translationally-controlled tumor protein OS=Homo sapiens OX=9606 GN=TPT1 PE=1 SV=1" "0.000" "False" "21.940" "39" "6" "14" "6" "172" "19.6" "4.93" "44.38" "6" "transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00838" "7178" "ENSG00000133112" "TPT1" "B2R7E5; hsa:7178; P13693; Q6YLS2; Q7Z4J4; Q8TBK7; Q96EE2; Q9UC70" "" "" "0" "0" "0.972" "1.020" "0.989" "1.012" "1.046" "0.997" "1.040" "1.135" "1.039" "1227.5" "1192.8" "1251.6" "1214.3" "1242.4" "1283.9" "1224.1" "1276.6" "1392.9" "1275.8" "" "" "" "" "" "" "" "" "" "" "1150.2" "987.0" "1162.0" "938.7" "1059.0" "1226.7" "1118.5" "1133.5" "1392.9" "1228.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6508547570803101910" "False" "High" "IsMasterProtein" "Q00169" "Phosphatidylinositol transfer protein alpha isoform OS=Homo sapiens OX=9606 GN=PITPNA PE=1 SV=2" "0.000" "False" "21.937" "36" "10" "15" "9" "270" "31.8" "6.55" "34.92" "10" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf02121" "5306" "ENSG00000174238" "PITPNA" "hsa:5306; Q00169" "" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Role of second messengers in netrin-1 signaling" "2" "1" "0.958" "1.032" "0.994" "0.969" "1.043" "1.062" "1.016" "1.046" "1.025" "1426.2" "1366.1" "1472.0" "1417.8" "1382.6" "1486.9" "1514.2" "1449.6" "1491.1" "1461.9" "" "" "" "" "" "" "" "" "" "" "1336.3" "1130.5" "1366.6" "1096.0" "1178.5" "1420.6" "1383.6" "1287.1" "1491.1" "1407.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6442873191784740439" "False" "High" "IsMasterProtein" "Q9BXW7" "Haloacid dehalogenase-like hydrolase domain-containing 5 OS=Homo sapiens OX=9606 GN=HDHD5 PE=1 SV=1" "0.000" "False" "21.920" "21" "7" "10" "7" "423" "46.3" "8.13" "37.34" "7" "other metabolic processes" "mitochondrion" "" "Pf13344" "27440" "ENSG00000069998" "HDHD5" "B2RCK5; Q9BXW7; Q9BXW8; Q9NWA8; Q9NX41" "" "" "0" "0" "1.034" "1.023" "1.029" "0.997" "1.008" "0.987" "1.019" "0.987" "1.019" "1461.5" "1510.9" "1495.4" "1503.8" "1457.5" "1473.3" "1442.1" "1489.7" "1442.7" "1488.8" "" "" "" "" "" "" "" "" "" "" "1369.5" "1250.2" "1388.3" "1162.5" "1242.4" "1407.6" "1317.7" "1322.7" "1442.7" "1433.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6052535811300559173" "False" "High" "IsMasterProtein" "Q2NL82" "Pre-rRNA-processing protein TSR1 homolog OS=Homo sapiens OX=9606 GN=TSR1 PE=1 SV=1" "0.000" "False" "21.914" "9" "7" "7" "7" "804" "91.8" "7.42" "22.34" "7" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04950, Pf08142" "55720" "ENSG00000167721" "TSR1" "hsa:55720; Q2NL82; Q8WUY5; Q9NVT0; Q9P2E6" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.040" "1.087" "1.123" "1.071" "1.008" "1.034" "0.978" "1.020" "1.066" "884.7" "919.7" "961.5" "993.6" "947.8" "892.1" "914.7" "865.2" "902.2" "943.0" "" "" "" "" "" "" "" "" "" "" "829.0" "761.1" "892.7" "768.1" "807.8" "852.3" "835.8" "768.2" "902.2" "908.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6980726595472841033" "False" "High" "IsMasterProtein" "P24941" "Cyclin-dependent kinase 2 OS=Homo sapiens OX=9606 GN=CDK2 PE=1 SV=2" "0.000" "False" "21.912" "19" "6" "11" "4" "298" "33.9" "8.68" "35.08" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069" "1017" "ENSG00000123374" "CDK2" "A8K7C6; hsa:1017; O75100; P24941" "miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; DNA replication; p53 transcriptional gene network; Pleural mesothelioma; Sphingolipid metabolism in senescence; Urotensin-II-mediated signaling pathway; ID signaling pathway; TROP2 regulatory signaling; DNA damage response" "CDK-mediated phosphorylation and removal of Cdc6; Regulation of APC/C activators between G1/S and early anaphase; Senescence-Associated Secretory Phenotype (SASP); TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Orc1 removal from chromatin; Regulation of TP53 Degradation; SCF(Skp2)-mediated degradation of p27/p21; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; G2 Phase; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Telomere Extension By Telomerase; Factors involved in megakaryocyte development and platelet production; Processing of DNA double-strand break ends; Cyclin A/B1/B2 associated events during G2/M transition; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Transcriptional regulation of granulopoiesis; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response; PTK6 Regulates Cell Cycle" "47" "0" "0.900" "0.989" "0.948" "0.950" "0.977" "0.907" "0.954" "0.956" "0.928" "916.2" "824.9" "906.4" "868.2" "870.3" "895.5" "830.5" "874.3" "875.4" "849.9" "" "" "" "" "" "" "" "" "" "" "858.4" "682.6" "841.5" "671.2" "741.8" "855.6" "758.9" "776.3" "875.4" "818.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5658103532290025162" "False" "High" "IsMasterProtein" "P49770" "Translation initiation factor eIF2B subunit beta OS=Homo sapiens OX=9606 GN=EIF2B2 PE=1 SV=3" "0.000" "False" "21.903" "24" "8" "10" "8" "351" "39.0" "6.16" "26.09" "8" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "8892" "ENSG00000119718" "EIF2B2" "hsa:8892; O43201; P49770" "Translation factors; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Rett syndrome; Primary ovarian insufficiency" "Recycling of eIF2:GDP" "5" "0" "0.989" "0.981" "1.101" "1.091" "1.099" "1.062" "0.992" "0.978" "1.056" "262.8" "260.0" "257.8" "289.5" "286.6" "288.8" "279.1" "260.7" "256.9" "277.4" "" "" "" "" "" "" "" "" "" "" "246.3" "215.1" "239.4" "223.8" "244.3" "275.9" "255.0" "231.5" "256.9" "267.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6712994512663593747" "False" "High" "IsMasterProtein" "Q4G0N4" "NAD kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=NADK2 PE=1 SV=2" "0.000" "False" "21.898" "18" "8" "10" "8" "442" "49.4" "8.18" "31.86" "8" "other metabolic processes" "mitochondrion" "kinase activity;other molecular function" "Pf01513" "133686" "ENSG00000152620" "NADK2" "B5MC93; hsa:133686; Q4G0N4; Q6UTX5; Q96NM0" "" "Mitochondrial protein degradation; Nicotinate metabolism" "2" "0" "0.971" "1.027" "1.076" "1.141" "1.165" "1.008" "1.046" "1.057" "1.051" "800.2" "777.2" "821.9" "861.4" "912.8" "932.3" "806.9" "837.1" "846.0" "840.9" "" "" "" "" "" "" "" "" "" "" "749.8" "643.1" "763.1" "665.9" "778.0" "890.7" "737.3" "743.3" "846.0" "809.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7073830227573610312" "False" "High" "IsMasterProtein" "Q9NR45" "Sialic acid synthase OS=Homo sapiens OX=9606 GN=NANS PE=1 SV=2" "0.000" "False" "21.882" "23" "7" "13" "7" "359" "40.3" "6.74" "45.77" "7" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf03102, Pf08666" "54187" "ENSG00000095380" "NANS" "B2RE98; Q8WUV9; Q9BWS6; Q9NR45; Q9NVD4" "Sialylation" "Sialic acid metabolism" "2" "0" "0.939" "1.033" "0.904" "0.935" "1.007" "0.942" "1.016" "1.045" "1.011" "1194.8" "1121.3" "1233.7" "1079.9" "1117.0" "1203.6" "1125.1" "1213.7" "1248.6" "1208.4" "" "" "" "" "" "" "" "" "" "" "1119.5" "927.9" "1145.3" "834.8" "952.1" "1150.0" "1028.1" "1077.6" "1248.6" "1163.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7841395992400372766" "False" "High" "IsMasterProtein" "Q9NVG8" "TBC1 domain family member 13 OS=Homo sapiens OX=9606 GN=TBC1D13 PE=1 SV=3" "0.000" "False" "21.882" "17" "7" "10" "7" "400" "46.5" "5.24" "32.08" "7" "transport" "other membranes;cytosol" "enzyme regulator activity;other molecular function" "Pf00566" "54662" "ENSG00000107021" "TBC1D13" "A7E2E7; B3KW04; B9EGJ8; hsa:54662; Q5T270; Q5T271; Q9NVG8" "" "TBC/RABGAPs" "1" "0" "1.035" "1.060" "1.120" "1.104" "1.119" "1.065" "1.066" "1.060" "1.080" "625.5" "647.4" "663.2" "700.8" "690.3" "699.8" "666.3" "666.5" "663.2" "675.3" "" "" "" "" "" "" "" "" "" "" "586.1" "535.7" "615.7" "541.7" "588.4" "668.5" "608.8" "591.8" "663.2" "650.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7848338417616042821" "False" "High" "IsMasterProtein" "P35270" "Sepiapterin reductase OS=Homo sapiens OX=9606 GN=SPR PE=1 SV=1" "0.000" "False" "21.859" "36" "8" "8" "8" "261" "28.0" "8.05" "21.18" "8" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00106" "6697" "ENSG00000116096" "SPR" "A8K741; D6W5H2; hsa:6697; P35270; Q53GI9; Q9UBB1" "" "eNOS activation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "2" "0" "1.020" "1.033" "1.067" "1.024" "1.057" "1.030" "1.046" "1.090" "1.038" "1134.4" "1157.5" "1171.4" "1210.8" "1161.5" "1199.2" "1168.2" "1186.3" "1236.4" "1177.1" "" "" "" "" "" "" "" "" "" "" "1062.9" "957.8" "1087.5" "936.0" "990.0" "1145.7" "1067.4" "1053.3" "1236.4" "1133.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6734575471453550747" "False" "High" "IsMasterProtein" "Q6FI81" "Anamorsin OS=Homo sapiens OX=9606 GN=CIAPIN1 PE=1 SV=2" "0.000" "False" "21.854" "24" "8" "13" "8" "312" "33.6" "5.62" "38.85" "8" "cell organization and biogenesis;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf05093, Pf20922" "57019" "ENSG00000005194" "CIAPIN1" "A8K8B6; hsa:57019; O75206; O75207; Q6FI81; Q9H0W1; Q9P1L7" "" "Cytosolic iron-sulfur cluster assembly" "1" "0" "0.943" "0.958" "1.023" "0.953" "0.984" "0.955" "0.937" "0.924" "0.981" "932.0" "878.7" "892.8" "953.5" "887.7" "916.7" "889.7" "873.1" "860.8" "914.5" "" "" "" "" "" "" "" "" "" "" "873.3" "727.1" "828.9" "737.1" "756.7" "875.8" "812.9" "775.2" "860.8" "880.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2257664793413269493" "False" "High" "IsMasterProtein" "Q69YN2" "CWF19-like protein 1 OS=Homo sapiens OX=9606 GN=CWF19L1 PE=1 SV=2" "0.000" "False" "21.851" "14" "8" "9" "8" "538" "60.6" "7.24" "25.78" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "enzyme regulator activity" "Pf04676, Pf04677" "55280" "ENSG00000095485" "CWF19L1" "B4DHX1; D3DR66; hsa:55280; Q5W0I3; Q69YN2; Q96HC3; Q9H865; Q9NV13" "" "" "0" "0" "1.023" "1.017" "1.005" "1.037" "0.999" "1.033" "1.016" "1.062" "0.988" "554.5" "567.1" "564.2" "557.3" "574.9" "553.9" "573.0" "563.3" "588.9" "547.6" "" "" "" "" "" "" "" "" "" "" "519.6" "469.3" "523.8" "430.8" "490.0" "529.2" "523.6" "500.1" "588.9" "527.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9194827022255966282" "False" "High" "IsMasterProtein" "Q9C0J8" "pre-mRNA 3' end processing protein WDR33 OS=Homo sapiens OX=9606 GN=WDR33 PE=1 SV=2" "0.000" "False" "21.836" "6" "8" "11" "8" "1336" "145.8" "9.17" "26.74" "8" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf01391" "55339" "ENSG00000136709" "WDR33" "hsa:55339; Q05DP8; Q53FG9; Q587J1; Q69YF7; Q6NUQ0; Q9C0J8; Q9NUL1" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA Derived from an Intronless Transcript; Processing of Intronless Pre-mRNAs" "5" "0" "1.071" "0.949" "1.245" "1.269" "1.081" "1.361" "1.293" "1.207" "1.141" "883.7" "946.1" "838.8" "1100.3" "1121.8" "954.9" "1203.0" "1143.0" "1066.7" "1008.6" "" "" "" "" "" "" "" "" "" "" "828.0" "782.9" "778.8" "850.6" "956.2" "912.4" "1099.2" "1014.9" "1066.7" "971.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6056072514061180880" "False" "High" "IsMasterProtein" "Q9Y2D5" "PALM2-AKAP2 fusion protein OS=Homo sapiens OX=9606 GN=PALM2AKAP2 PE=1 SV=4" "0.000" "False" "21.826" "7" "8" "9" "8" "1103" "122.0" "5.06" "27.22" "8" "" "plasma membrane;other membranes" "" "Pf03285, Pf15304" "445815" "ENSG00000157654" "PALM2AKAP2" "A9Z1X9; B1ALX9; B2RTU4; B3KQ00; B4DTZ2; B7ZW07; B9EJB5; hsa:445815; Q8IXS6; Q8N9D5; Q96DU1; Q9UG26; Q9Y2D5" "" "" "0" "0" "1.005" "0.977" "1.111" "1.155" "1.050" "1.237" "1.266" "1.218" "1.127" "1002.6" "1007.9" "980.0" "1114.1" "1157.7" "1052.5" "1240.6" "1269.6" "1220.7" "1129.7" "" "" "" "" "" "" "" "" "" "" "939.4" "834.0" "909.8" "861.2" "986.8" "1005.6" "1133.6" "1127.3" "1220.7" "1087.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5991107467839093977" "False" "High" "IsMasterProtein" "Q99747" "Gamma-soluble NSF attachment protein OS=Homo sapiens OX=9606 GN=NAPG PE=1 SV=1" "0.000" "False" "21.798" "26" "8" "10" "8" "312" "34.7" "5.41" "27.44" "8" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf14938" "8774" "ENSG00000134265" "NAPG" "B4DFC9; hsa:8774; Q99747; Q9BUV1" "" "COPII-mediated vesicle transport; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "5" "0" "1.072" "1.019" "1.146" "1.150" "1.081" "1.069" "1.079" "1.078" "1.091" "605.9" "649.6" "617.7" "694.6" "697.0" "654.9" "648.0" "653.6" "653.2" "661.3" "" "" "" "" "" "" "" "" "" "" "567.8" "537.6" "573.4" "537.0" "594.1" "625.7" "592.1" "580.4" "653.2" "636.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604354164667528726" "False" "High" "IsMasterProtein" "Q13769" "THO complex subunit 5 homolog OS=Homo sapiens OX=9606 GN=THOC5 PE=1 SV=2" "0.000" "False" "21.793" "10" "7" "8" "7" "683" "78.5" "6.87" "26.48" "7" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09766" "8563" "ENSG00000100296" "THOC5" "hsa:8563; O60839; Q13769; Q9UPZ5" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Signaling by CSF1 (M-CSF) in myeloid cells" "4" "0" "0.995" "1.085" "1.078" "1.138" "1.195" "1.339" "1.372" "1.298" "1.187" "753.6" "750.1" "817.4" "812.5" "857.8" "900.3" "1009.0" "1033.9" "978.5" "894.3" "" "" "" "" "" "" "" "" "" "" "706.1" "620.7" "758.8" "628.1" "731.2" "860.2" "921.9" "918.0" "978.5" "861.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4265990204774033592" "False" "High" "IsMasterProtein" "O75175" "CCR4-NOT transcription complex subunit 3 OS=Homo sapiens OX=9606 GN=CNOT3 PE=1 SV=1" "0.000" "False" "21.762" "7" "6" "9" "6" "753" "81.8" "6.20" "27.41" "6" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04065, Pf04153" "4849" "ENSG00000088038; ENSG00000273943; ENSG00000274176; ENSG00000274616; ENSG00000274941; ENSG00000275979; ENSG00000276082; ENSG00000277114; ENSG00000277600; ENSG00000277615" "CNOT3" "hsa:4849; O75175; Q9NZN7; Q9UF76" "" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "1.023" "0.991" "1.020" "1.021" "1.011" "1.060" "1.042" "1.035" "1.032" "863.1" "883.1" "855.1" "880.1" "881.5" "872.4" "914.8" "899.1" "893.5" "890.8" "" "" "" "" "" "" "" "" "" "" "808.8" "730.7" "793.9" "680.4" "751.3" "833.5" "835.9" "798.3" "893.5" "857.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-763212604296308746" "False" "High" "IsMasterProtein" "Q8IXH7" "Negative elongation factor C/D OS=Homo sapiens OX=9606 GN=NELFCD PE=1 SV=2" "0.000" "False" "21.758" "15" "9" "10" "9" "590" "66.2" "5.10" "26.58" "9" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf04858" "51497" "ENSG00000101158" "NELFCD" "B4DE06; hsa:51497; Q8IXH7; Q9BYL2; Q9H405; Q9H888; Q9H8T3; Q9NVX5; Q9P029; Q9UGN1; Q9UGN2; Q9UGN3" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "16" "0" "1.138" "1.078" "1.216" "1.173" "1.104" "1.169" "1.101" "1.035" "1.106" "301.1" "342.6" "324.5" "366.1" "353.2" "332.4" "352.0" "331.5" "311.6" "333.0" "" "" "" "" "" "" "" "" "" "" "282.1" "283.5" "301.2" "283.0" "301.1" "317.6" "321.6" "294.3" "311.6" "320.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5974155710491899055" "False" "High" "IsMasterProtein" "Q9UHD2" "Serine/threonine-protein kinase TBK1 OS=Homo sapiens OX=9606 GN=TBK1 PE=1 SV=1" "0.000" "False" "21.737" "11" "7" "7" "7" "729" "83.6" "6.79" "24.15" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069, Pf18394, Pf18396" "29110" "ENSG00000183735" "TBK1" "A8K4S4; hsa:29110; Q8IYV3; Q9NUJ5; Q9UHD2" "TNF-alpha signaling pathway; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19; Toll-like receptor signaling pathway" "SARS-CoV-1 activates/modulates innate immune responses; Interleukin-37 signaling; Regulation of TNFR1 signaling; TNFR1-induced proapoptotic signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Negative regulators of DDX58/IFIH1 signaling; Potential therapeutics for SARS; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; TICAM1-dependent activation of IRF3/IRF7; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Regulation of innate immune responses to cytosolic DNA; IRF3-mediated induction of type I IFN; STAT6-mediated induction of chemokines; IRF3 mediated activation of type 1 IFN" "35" "0" "1.026" "1.088" "0.922" "0.946" "0.956" "0.947" "0.908" "0.948" "0.992" "709.2" "727.4" "771.4" "654.0" "670.9" "678.0" "671.7" "644.1" "672.0" "703.6" "" "" "" "" "" "" "" "" "" "" "664.6" "601.9" "716.2" "505.6" "571.9" "647.8" "613.8" "571.9" "672.0" "677.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2561010377563702326" "False" "High" "IsMasterProtein" "Q8WX92" "Negative elongation factor B OS=Homo sapiens OX=9606 GN=NELFB PE=1 SV=1" "0.000" "False" "21.737" "14" "8" "9" "8" "580" "65.7" "6.13" "26.64" "8" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf06209" "25920" "ENSG00000188986" "NELFB" "A0A0X1KG71; A2BFA3; hsa:25920; Q8WX92; Q96EW5; Q9H9R4; Q9ULN8; Q9Y3W0" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation; 5q35 copy number variation" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; TP53 Regulates Transcription of DNA Repair Genes; NTRK3 as a dependence receptor" "18" "0" "0.985" "1.027" "1.012" "1.048" "1.037" "1.025" "0.967" "1.016" "1.011" "1550.8" "1528.3" "1593.1" "1570.0" "1625.8" "1608.6" "1589.6" "1500.3" "1576.2" "1567.9" "" "" "" "" "" "" "" "" "" "" "1453.1" "1264.7" "1479.0" "1213.7" "1385.8" "1536.8" "1452.4" "1332.1" "1576.2" "1509.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4088167174397650062" "False" "High" "IsMasterProtein" "Q9BV20" "Methylthioribose-1-phosphate isomerase OS=Homo sapiens OX=9606 GN=MRI1 PE=1 SV=1" "0.000" "False" "21.735" "18" "7" "8" "7" "369" "39.1" "6.30" "23.49" "7" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01008" "84245" "ENSG00000037757" "MRI1" "hsa:84245; Q8NDC9; Q9BV20" "Methionine de novo and salvage pathway" "Methionine salvage pathway" "2" "0" "0.935" "0.934" "0.935" "0.945" "0.934" "0.909" "0.940" "0.924" "0.923" "896.6" "838.1" "837.2" "838.8" "847.4" "837.8" "814.6" "843.1" "828.4" "827.8" "" "" "" "" "" "" "" "" "" "" "840.1" "693.5" "777.2" "648.4" "722.3" "800.4" "744.4" "748.6" "828.4" "797.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4732323992224053242" "False" "High" "IsMasterProtein" "Q9NU22" "Midasin OS=Homo sapiens OX=9606 GN=MDN1 PE=1 SV=2" "0.000" "False" "21.693" "1" "8" "9" "8" "5596" "632.4" "5.68" "27.91" "8" "cell organization and biogenesis;transport" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07728, Pf17865, Pf17867, Pf21108" "23195" "ENSG00000112159" "MDN1" "hsa:23195; O15019; Q5T794; Q9NU22" "" "" "0" "0" "1.072" "1.003" "1.238" "1.120" "1.082" "1.598" "1.456" "1.493" "1.222" "598.2" "641.5" "599.9" "740.3" "669.8" "647.1" "955.7" "870.9" "893.3" "731.3" "" "" "" "" "" "" "" "" "" "" "560.5" "530.8" "556.9" "572.3" "570.9" "618.2" "873.2" "773.3" "893.3" "704.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7145479494712382587" "False" "High" "IsMasterProtein" "P80217" "Interferon-induced 35 kDa protein OS=Homo sapiens OX=9606 GN=IFI35 PE=1 SV=5" "0.000" "False" "21.659" "32" "9" "10" "9" "286" "31.5" "6.09" "27.80" "9" "stress response;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf07292, Pf07334" "3430" "ENSG00000068079" "IFI35" "C9JGX1; hsa:3430; P80217; Q92984; Q99537; Q9BV98" "Immune response to tuberculosis" "Interferon alpha/beta signaling" "2" "0" "0.885" "0.994" "0.976" "1.000" "0.991" "1.028" "0.964" "0.896" "0.945" "320.8" "283.9" "318.9" "313.2" "320.7" "317.9" "329.8" "309.3" "287.3" "303.0" "" "" "" "" "" "" "" "" "" "" "300.6" "235.0" "296.1" "242.1" "273.3" "303.8" "301.4" "274.6" "287.3" "291.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8922027540744871533" "False" "High" "IsMasterProtein" "Q9UHQ1" "Nuclear prelamin A recognition factor OS=Homo sapiens OX=9606 GN=NARF PE=1 SV=1" "0.000" "False" "21.645" "14" "6" "7" "6" "456" "51.1" "7.08" "20.64" "6" "" "cytoskeleton;nucleus" "other molecular function" "Pf02256, Pf02906" "26502" "ENSG00000141562" "NARF" "A6NCJ3; B3KPX2; hsa:26502; K4DI98; Q96AY9; Q9BWC6; Q9UHQ1" "Iron-sulfur cluster biogenesis" "" "1" "0" "0.937" "0.973" "0.963" "0.967" "0.967" "0.899" "0.864" "0.931" "0.971" "707.9" "663.0" "688.7" "681.8" "684.3" "684.5" "636.1" "611.7" "658.9" "687.7" "" "" "" "" "" "" "" "" "" "" "663.3" "548.7" "639.4" "527.1" "583.2" "654.0" "581.2" "543.2" "658.9" "662.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4626058579617190840" "False" "High" "IsMasterProtein" "Q5VYS8" "Terminal uridylyltransferase 7 OS=Homo sapiens OX=9606 GN=TUT7 PE=1 SV=1" "0.000" "False" "21.637" "6" "7" "7" "6" "1495" "171.1" "6.83" "21.23" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098, Pf03828, Pf16631, Pf19088" "79670" "ENSG00000083223" "TUT7" "hsa:79670; Q5H9T0; Q5VYS5; Q5VYS7; Q5VYS8; Q658Z9; Q659A2; Q6MZJ3; Q8N5F0; Q96N57; Q96NE8; Q9C0F2; Q9H8M6" "" "Zygotic genome activation (ZGA); Deadenylation of mRNA; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "3" "0" "1.024" "1.025" "0.978" "0.985" "0.959" "0.937" "0.862" "0.946" "0.952" "394.1" "403.6" "403.8" "385.3" "388.0" "378.0" "369.4" "339.6" "372.8" "375.3" "" "" "" "" "" "" "" "" "" "" "369.3" "333.9" "374.9" "297.8" "330.7" "361.2" "337.6" "301.5" "372.8" "361.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4943228809179220327" "False" "High" "IsMasterProtein" "Q8IWX8" "Calcium homeostasis endoplasmic reticulum protein OS=Homo sapiens OX=9606 GN=CHERP PE=1 SV=3" "0.000" "False" "21.629" "8" "8" "9" "8" "916" "103.6" "9.04" "25.23" "8" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01585, Pf01805, Pf04818" "10523" "ENSG00000085872" "CHERP" "hsa:10523; O00302; Q4G0Y5; Q8IWX8; Q8WU30; Q99492" "" "mRNA Splicing - Major Pathway" "1" "0" "1.000" "1.100" "1.143" "1.086" "1.061" "1.537" "1.420" "1.494" "1.215" "1007.9" "1007.7" "1108.8" "1152.3" "1094.1" "1069.9" "1549.2" "1430.9" "1505.4" "1225.0" "" "" "" "" "" "" "" "" "" "" "944.4" "833.9" "1029.4" "890.8" "932.6" "1022.2" "1415.5" "1270.5" "1505.4" "1179.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7469427958651967746" "False" "High" "IsMasterProtein" "Q9GZL7" "Ribosome biogenesis protein WDR12 OS=Homo sapiens OX=9606 GN=WDR12 PE=1 SV=2" "0.000" "False" "21.625" "18" "7" "7" "7" "423" "47.7" "5.90" "25.74" "7" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf08154" "55759" "ENSG00000138442" "WDR12" "B3KPA9; hsa:55759; Q96HU0; Q9GZL7; Q9NV80; Q9NYI8" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "0.992" "0.953" "1.115" "0.973" "1.031" "0.958" "1.073" "1.014" "1.005" "398.6" "395.4" "379.7" "444.4" "387.7" "411.2" "382.1" "427.6" "404.2" "400.5" "" "" "" "" "" "" "" "" "" "" "373.5" "327.1" "352.5" "343.6" "330.5" "392.8" "349.1" "379.7" "404.2" "385.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6887775823956767803" "False" "High" "IsMasterProtein" "P25440" "Bromodomain-containing protein 2 OS=Homo sapiens OX=9606 GN=BRD2 PE=1 SV=2" "0.000" "False" "21.617" "8" "8" "8" "6" "801" "88.0" "9.09" "24.30" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00439, Pf17035" "6046" "ENSG00000204256; ENSG00000215077; ENSG00000234507; ENSG00000234704; ENSG00000235307" "BRD2" "A2AAU0; B0S7P0; B1AZT1; O00699; O00700; P25440; Q15310; Q5STC9; Q63HQ9; Q658Y7; Q6P3U2; Q969U4" "" "RUNX3 regulates p14-ARF" "1" "0" "1.013" "1.079" "1.168" "1.120" "1.071" "1.138" "1.102" "1.019" "1.111" "414.2" "419.7" "447.0" "483.8" "463.9" "443.7" "471.4" "456.6" "422.1" "460.0" "" "" "" "" "" "" "" "" "" "" "388.1" "347.3" "415.0" "374.0" "395.4" "423.9" "430.8" "405.4" "422.1" "442.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7436482478148807515" "False" "High" "IsMasterProtein" "Q86TB9" "Protein PAT1 homolog 1 OS=Homo sapiens OX=9606 GN=PATL1 PE=1 SV=2" "0.000" "False" "21.603" "11" "9" "16" "9" "770" "86.8" "6.67" "43.48" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf09770" "219988" "ENSG00000166889" "PATL1" "B3KXT9; hsa:219988; Q2TA86; Q6P166; Q86TB9; Q8N9M6; Q8NI63" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "0.969" "1.011" "1.055" "1.010" "1.020" "0.984" "0.936" "0.925" "0.968" "1129.4" "1094.3" "1141.3" "1191.0" "1140.9" "1151.5" "1111.3" "1056.9" "1044.8" "1093.2" "" "" "" "" "" "" "" "" "" "" "1058.2" "905.5" "1059.6" "920.7" "972.4" "1100.2" "1015.4" "938.5" "1044.8" "1052.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819475231177228561" "False" "High" "IsMasterProtein" "O94966" "Ubiquitin carboxyl-terminal hydrolase 19 OS=Homo sapiens OX=9606 GN=USP19 PE=1 SV=2" "0.000" "False" "21.594" "6" "7" "7" "7" "1318" "145.6" "6.28" "23.48" "7" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00443, Pf01753, Pf04969, Pf16602" "10869" "ENSG00000172046" "USP19" "A5PKX8; A6H8U2; B4DGT3; B4DTZ0; E7EN22; E7ETS0; E9PEG8; hsa:10869; O94966; Q3KQW4; Q641Q9; Q6NZY8; Q86XV9" "Warburg effect modulated by deubiquitinating enzymes and their substrates" "Ub-specific processing proteases" "2" "0" "1.007" "0.998" "1.040" "1.023" "1.009" "0.974" "0.988" "1.055" "1.015" "596.8" "600.8" "595.7" "620.8" "610.5" "602.4" "581.5" "589.8" "629.8" "606.0" "" "" "" "" "" "" "" "" "" "" "559.2" "497.1" "553.0" "479.9" "520.4" "575.5" "531.3" "523.7" "629.8" "583.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6137891794897938593" "False" "High" "IsMasterProtein" "Q8NEF9" "Serum response factor-binding protein 1 OS=Homo sapiens OX=9606 GN=SRFBP1 PE=1 SV=1" "0.000" "False" "21.575" "15" "7" "8" "7" "429" "48.6" "9.58" "20.94" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf09073" "153443" "ENSG00000151304" "SRFBP1" "hsa:153443; Q5QFI2; Q8NEF9; Q96AH4; Q96DK2" "" "" "0" "0" "1.038" "1.033" "1.068" "1.106" "1.122" "1.085" "1.163" "1.118" "1.126" "1441.0" "1495.1" "1488.3" "1539.1" "1593.9" "1617.1" "1563.7" "1676.4" "1611.2" "1622.7" "" "" "" "" "" "" "" "" "" "" "1350.2" "1237.2" "1381.7" "1189.8" "1358.6" "1545.0" "1428.8" "1488.5" "1611.2" "1562.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6575601821171362980" "False" "High" "IsMasterProtein" "P39019" "Small ribosomal subunit protein eS19 OS=Homo sapiens OX=9606 GN=RPS19 PE=1 SV=2" "0.000" "False" "21.534" "46" "7" "10" "7" "145" "16.1" "10.32" "38.74" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01090" "6223" "ENSG00000105372" "RPS19" "hsa:6223; P39019" "Complement system; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "20" "0" "1.117" "1.169" "1.089" "1.098" "1.114" "1.326" "1.264" "1.323" "1.148" "1531.8" "1711.4" "1790.6" "1668.8" "1681.7" "1706.2" "2031.8" "1935.5" "2027.1" "1758.8" "" "" "" "" "" "" "" "" "" "" "1435.3" "1416.1" "1662.3" "1290.1" "1433.4" "1630.1" "1856.5" "1718.5" "2027.1" "1693.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3047103662304523242" "False" "High" "IsMasterProtein" "Q9ULD9" "Zinc finger protein 608 OS=Homo sapiens OX=9606 GN=ZNF608 PE=1 SV=4" "0.000" "False" "21.513" "5" "7" "9" "7" "1512" "162.1" "8.79" "26.72" "7" "other biological processes" "nucleus" "other molecular function" "" "57507" "ENSG00000168916" "ZNF608" "A7E2W9; hsa:57507; Q3SYM6; Q68D12; Q8IY05; Q9ULD9; Q9Y5A1" "" "" "0" "0" "0.951" "0.968" "0.982" "1.016" "0.970" "1.100" "1.016" "1.002" "1.037" "694.5" "660.2" "672.1" "682.1" "705.8" "673.9" "763.7" "705.9" "695.7" "720.5" "" "" "" "" "" "" "" "" "" "" "650.7" "546.3" "624.0" "527.3" "601.6" "643.8" "697.8" "626.8" "695.7" "693.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4839945324263831738" "False" "High" "IsMasterProtein" "Q9NTX5" "Ethylmalonyl-CoA decarboxylase OS=Homo sapiens OX=9606 GN=ECHDC1 PE=1 SV=2" "0.000" "False" "21.486" "24" "7" "11" "7" "307" "33.7" "8.21" "30.24" "7" "other metabolic processes" "cytosol" "other molecular function" "Pf00378" "55862" "ENSG00000093144" "ECHDC1" "A6NFJ5; B7Z8S0; E9PEN7; E9PR31; F8W851; hsa:55862; Q5TEF6; Q5TEF7; Q5TEG0; Q5TEG4; Q9NTX5; Q9NZ30; V9HW18" "Fatty acid biosynthesis" "" "1" "0" "0.931" "0.960" "1.027" "0.979" "0.964" "0.978" "0.918" "0.907" "0.946" "776.2" "722.7" "745.5" "797.2" "759.8" "748.4" "758.8" "712.4" "703.8" "734.4" "" "" "" "" "" "" "" "" "" "" "727.3" "598.1" "692.1" "616.2" "647.6" "715.0" "693.3" "632.6" "703.8" "707.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8849242953917426165" "False" "High" "IsMasterProtein" "Q9HCD5" "Nuclear receptor coactivator 5 OS=Homo sapiens OX=9606 GN=NCOA5 PE=1 SV=2" "0.000" "False" "21.485" "12" "7" "8" "7" "579" "65.5" "9.60" "25.34" "7" "signal transduction;other biological processes" "cytoskeleton;nucleus" "other molecular function" "" "57727" "ENSG00000124160" "NCOA5" "B2RTV9; E1P5R0; Q6HA99; Q9H1F2; Q9H2T2; Q9H4Y9; Q9HCD5" "" "" "0" "0" "0.991" "1.010" "1.071" "1.113" "1.091" "1.435" "1.435" "1.418" "1.205" "1102.7" "1093.2" "1113.8" "1181.2" "1227.0" "1203.1" "1582.4" "1582.6" "1563.4" "1329.1" "" "" "" "" "" "" "" "" "" "" "1033.2" "904.6" "1034.0" "913.1" "1045.9" "1149.5" "1445.9" "1405.2" "1563.4" "1279.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5388836657935240768" "False" "High" "IsMasterProtein" "Q12872" "Splicing factor, suppressor of white-apricot homolog OS=Homo sapiens OX=9606 GN=SFSWAP PE=1 SV=3" "0.000" "False" "21.481" "9" "8" "8" "8" "951" "104.8" "8.05" "21.13" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf01805, Pf09750" "6433" "ENSG00000061936" "SFSWAP" "B2RN45; B7ZM97; F5H6B8; hsa:6433; Q12872; Q6PJF7" "mRNA processing" "" "1" "0" "1.009" "1.029" "1.019" "1.119" "1.157" "1.384" "1.478" "1.455" "1.165" "809.4" "816.8" "832.8" "824.9" "905.4" "936.7" "1120.5" "1196.3" "1178.0" "943.4" "" "" "" "" "" "" "" "" "" "" "758.4" "675.9" "773.1" "637.7" "771.8" "894.9" "1023.8" "1062.2" "1178.0" "908.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5945011317712517661" "False" "High" "IsMasterProtein" "P25787" "Proteasome subunit alpha type-2 OS=Homo sapiens OX=9606 GN=PSMA2 PE=1 SV=2" "0.000" "False" "21.472" "38" "6" "8" "6" "234" "25.9" "7.43" "31.19" "6" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5683" "ENSG00000106588" "PSMA2" "hsa:5683; P25787; Q6ICS6; Q9BU45" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "1.046" "0.965" "1.030" "0.987" "1.050" "0.896" "0.900" "1.043" "0.991" "1000.7" "1046.5" "965.5" "1030.4" "987.6" "1050.6" "896.9" "901.1" "1044.2" "991.3" "" "" "" "" "" "" "" "" "" "" "937.7" "866.0" "896.4" "796.5" "841.8" "1003.7" "819.5" "800.1" "1044.2" "954.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8302543892740036521" "False" "High" "IsMasterProtein" "P82970" "High mobility group nucleosome-binding domain-containing protein 5 OS=Homo sapiens OX=9606 GN=HMGN5 PE=1 SV=1" "0.000" "False" "21.459" "32" "7" "11" "7" "282" "31.5" "4.55" "37.53" "7" "cell organization and biogenesis;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "79366" "ENSG00000198157" "HMGN5" "hsa:79366; P82970; Q5JSL1" "" "" "0" "0" "1.077" "0.997" "1.018" "1.019" "0.937" "0.937" "1.037" "1.003" "0.999" "1193.1" "1284.9" "1189.0" "1214.9" "1215.7" "1118.2" "1118.0" "1237.0" "1196.5" "1191.8" "" "" "" "" "" "" "" "" "" "" "1117.9" "1063.3" "1103.8" "939.1" "1036.2" "1068.3" "1021.6" "1098.3" "1196.5" "1147.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7337665348008384774" "False" "High" "IsMasterProtein" "O60701" "UDP-glucose 6-dehydrogenase OS=Homo sapiens OX=9606 GN=UGDH PE=1 SV=1" "0.000" "False" "21.458" "15" "6" "6" "6" "494" "55.0" "7.12" "24.14" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;nucleus" "other molecular function" "Pf00984, Pf03720, Pf03721" "7358" "ENSG00000109814" "UGDH" "B3KUU2; B4DN25; hsa:7358; O60589; O60701" "UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "Formation of the active cofactor, UDP-glucuronate" "3" "0" "0.928" "1.002" "0.937" "0.930" "0.919" "0.908" "1.023" "0.998" "0.940" "1343.6" "1246.7" "1346.6" "1259.5" "1249.2" "1234.6" "1220.5" "1374.0" "1340.7" "1263.5" "" "" "" "" "" "" "" "" "" "" "1258.9" "1031.6" "1250.1" "973.7" "1064.8" "1179.5" "1115.2" "1220.0" "1340.7" "1216.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6631585726403495176" "False" "High" "IsMasterProtein" "O14787" "Transportin-2 OS=Homo sapiens OX=9606 GN=TNPO2 PE=1 SV=3" "0.000" "False" "21.449" "8" "7" "10" "2" "897" "101.3" "5.01" "33.39" "7" "transport" "nucleus;other cell component" "other molecular function" "Pf02985, Pf03810" "30000" "ENSG00000105576" "TNPO2" "hsa:30000; O14655; O14787; Q6IN77" "" "" "0" "0" "1.151" "1.056" "0.946" "1.023" "1.000" "0.972" "0.997" "1.037" "1.052" "384.0" "441.9" "405.4" "363.3" "393.1" "384.1" "373.4" "382.8" "398.3" "404.0" "" "" "" "" "" "" "" "" "" "" "359.8" "365.6" "376.4" "280.8" "335.0" "367.0" "341.2" "339.9" "398.3" "389.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8831328934271129534" "False" "High" "IsMasterProtein" "Q92733" "Proline-rich protein PRCC OS=Homo sapiens OX=9606 GN=PRCC PE=1 SV=1" "0.000" "False" "21.448" "16" "6" "10" "6" "491" "52.4" "5.10" "37.86" "6" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf10253" "5546" "ENSG00000143294" "PRCC" "A8K1F7; hsa:5546; O00665; O00724; Q5SZ06; Q92733" "MET in type 1 papillary renal cell carcinoma; Type 2 papillary renal cell carcinoma; IL-18 signaling pathway" "mRNA Splicing - Major Pathway" "4" "0" "1.059" "1.117" "1.083" "1.099" "1.062" "1.028" "1.132" "1.057" "1.094" "828.5" "877.7" "925.1" "897.7" "910.5" "879.8" "852.1" "938.3" "876.1" "906.2" "" "" "" "" "" "" "" "" "" "" "776.3" "726.3" "858.9" "693.9" "776.1" "840.6" "778.6" "833.1" "876.1" "872.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2201882454177381815" "False" "High" "IsMasterProtein" "P63241" "Eukaryotic translation initiation factor 5A-1 OS=Homo sapiens OX=9606 GN=EIF5A PE=1 SV=2" "0.000" "False" "21.446" "37" "6" "14" "6" "154" "16.8" "5.24" "39.13" "6" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01287, Pf21485" "1984" "ENSG00000132507; ENSG00000288145" "EIF5A" "A8K9A0; D3DTP2; hsa:1984; P10159; P63241; Q16182; Q7L7L3; Q7Z4L1; Q9D0G2" "Translation factors; eIF5A regulation in response to inhibition of the nuclear export system" "Hypusine synthesis from eIF5A-lysine" "3" "0" "1.055" "0.976" "1.015" "1.033" "1.023" "1.011" "0.955" "1.036" "0.977" "1726.6" "1821.0" "1684.8" "1752.5" "1784.2" "1766.1" "1746.4" "1649.2" "1788.1" "1687.6" "" "" "" "" "" "" "" "" "" "" "1617.9" "1506.8" "1564.1" "1354.7" "1520.8" "1687.4" "1595.7" "1464.4" "1788.1" "1624.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2253036871243965201" "False" "High" "IsMasterProtein" "Q15014" "Mortality factor 4-like protein 2 OS=Homo sapiens OX=9606 GN=MORF4L2 PE=1 SV=1" "0.000" "False" "21.433" "20" "5" "6" "3" "288" "32.3" "9.72" "20.84" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "" "Pf05712" "9643" "ENSG00000123562" "MORF4L2" "B3KP92; D3DXA5; hsa:9643; Q15014; Q567V0; Q8J026" "" "HATs acetylate histones" "1" "0" "1.020" "1.016" "1.066" "0.956" "0.905" "0.940" "0.918" "0.894" "0.944" "412.2" "420.6" "418.7" "439.5" "393.9" "372.9" "387.5" "378.5" "368.4" "389.0" "" "" "" "" "" "" "" "" "" "" "386.2" "348.0" "388.7" "339.8" "335.8" "356.3" "354.1" "336.1" "368.4" "374.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2767928129327746769" "False" "High" "IsMasterProtein" "O14950" "Myosin regulatory light chain 12B OS=Homo sapiens OX=9606 GN=MYL12B PE=1 SV=2" "0.000" "False" "21.429" "47" "7" "12" "7" "172" "19.8" "4.84" "33.12" "7" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf08976, Pf13499" "103910; 10627" "ENSG00000118680" "MYL12B" "D3DUH6; hsa:103910; O14950; Q13182; Q7Z5Z4" "Thyroid stimulating hormone (TSH) signaling pathway; Focal adhesion" "RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "9" "0" "1.097" "1.029" "1.068" "1.028" "1.054" "1.010" "1.003" "1.043" "1.018" "1405.4" "1541.9" "1446.0" "1501.3" "1444.4" "1481.2" "1418.8" "1409.5" "1465.8" "1430.1" "" "" "" "" "" "" "" "" "" "" "1316.8" "1275.9" "1342.4" "1160.6" "1231.2" "1415.2" "1296.4" "1251.5" "1465.8" "1377.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6049442156646566229" "False" "High" "IsMasterProtein" "Q6UXN9" "WD repeat-containing protein 82 OS=Homo sapiens OX=9606 GN=WDR82 PE=1 SV=1" "0.000" "False" "21.427" "23" "8" "10" "8" "313" "35.1" "7.69" "30.70" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400" "80335" "ENSG00000164091" "WDR82" "A8K5R5; hsa:80335; Q6UXN9; Q8TEB2" "" "Formation of WDR5-containing histone-modifying complexes" "1" "0" "1.022" "1.109" "0.945" "1.042" "1.090" "1.050" "1.151" "1.160" "1.084" "580.4" "593.4" "643.8" "548.5" "604.9" "632.8" "609.6" "668.1" "673.0" "629.3" "" "" "" "" "" "" "" "" "" "" "543.8" "491.0" "597.6" "424.1" "515.6" "604.6" "557.0" "593.2" "673.0" "605.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7652692427915398655" "False" "High" "IsMasterProtein" "Q9H0H5" "Rac GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RACGAP1 PE=1 SV=1" "0.000" "False" "21.397" "11" "9" "12" "9" "632" "71.0" "8.88" "29.34" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00130, Pf00620" "29127" "ENSG00000161800" "RACGAP1" "hsa:29127; Q6PJ26; Q9H0H5; Q9NWN2; Q9P250; Q9P2W2" "S1P receptor signal transduction; Wnt signaling pathway and pluripotency" "CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHOC GTPase cycle; RHOA GTPase cycle; MHC class II antigen presentation; RHOB GTPase cycle; RHOD GTPase cycle" "13" "0" "1.058" "1.073" "1.093" "1.030" "1.076" "1.022" "0.972" "0.898" "1.031" "594.9" "629.4" "638.2" "650.1" "612.7" "640.0" "608.2" "578.4" "534.4" "613.4" "" "" "" "" "" "" "" "" "" "" "557.4" "520.8" "592.5" "502.6" "522.3" "611.5" "555.7" "513.6" "534.4" "590.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8361684917289872737" "False" "High" "IsMasterProtein" "Q9BSW2" "EF-hand calcium-binding domain-containing protein 4B OS=Homo sapiens OX=9606 GN=CRACR2A PE=1 SV=2" "0.000" "False" "21.382" "8" "7" "9" "7" "731" "83.1" "5.24" "26.60" "7" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00071, Pf13499" "84766" "ENSG00000130038" "CRACR2A" "B4E1X0; B9EK63; hsa:84766; Q9BSW2" "Vitamin D receptor pathway" "Neutrophil degranulation" "2" "0" "0.969" "0.977" "0.984" "1.026" "0.973" "0.973" "0.984" "0.959" "0.972" "1006.7" "975.0" "983.7" "990.5" "1032.7" "979.7" "979.3" "990.4" "965.6" "978.4" "" "" "" "" "" "" "" "" "" "" "943.2" "806.8" "913.3" "765.7" "880.3" "936.0" "894.8" "879.4" "965.6" "942.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570011154676120481" "False" "High" "IsMasterProtein" "Q9NRF9" "DNA polymerase epsilon subunit 3 OS=Homo sapiens OX=9606 GN=POLE3 PE=1 SV=1" "0.000" "False" "21.381" "40" "6" "9" "6" "147" "16.8" "4.74" "29.14" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "54107" "ENSG00000148229" "POLE3" "hsa:54107; Q5W0U1; Q8N758; Q8NCE5; Q9NR32; Q9NRF9" "Pyrimidine metabolism; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Activation of the pre-replicative complex; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; PCNA-Dependent Long Patch Base Excision Repair; DNA replication initiation" "16" "0" "1.157" "1.059" "1.008" "1.031" "1.047" "0.938" "0.996" "1.020" "1.073" "1663.4" "1925.1" "1762.2" "1676.9" "1715.1" "1741.3" "1561.0" "1656.2" "1697.3" "1784.5" "" "" "" "" "" "" "" "" "" "" "1558.6" "1593.0" "1636.0" "1296.3" "1461.9" "1663.7" "1426.4" "1470.5" "1697.3" "1718.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4023730213020721894" "False" "High" "IsMasterProtein" "Q9NVX2" "Notchless protein homolog 1 OS=Homo sapiens OX=9606 GN=NLE1 PE=1 SV=4" "0.000" "False" "21.361" "19" "7" "8" "7" "485" "53.3" "7.34" "30.15" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus" "" "Pf00400, Pf08154" "54475" "ENSG00000073536" "NLE1" "hsa:54475; O60868; Q59GJ8; Q9BU54; Q9NVX2" "17q12 copy number variation syndrome" "" "1" "0" "1.063" "1.029" "1.031" "1.011" "1.064" "1.019" "1.039" "1.086" "1.086" "943.1" "1002.7" "970.8" "972.4" "953.8" "1003.5" "961.5" "979.5" "1023.9" "1024.3" "" "" "" "" "" "" "" "" "" "" "883.7" "829.7" "901.3" "751.7" "813.0" "958.8" "878.5" "869.7" "1023.9" "986.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7212838211136634633" "False" "High" "IsMasterProtein" "Q9NYY8" "FAST kinase domain-containing protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=FASTKD2 PE=1 SV=1" "0.000" "False" "21.360" "12" "7" "9" "7" "710" "81.4" "8.05" "27.41" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "nucleic acid binding activity" "Pf06743, Pf08368, Pf08373" "22868" "ENSG00000118246" "FASTKD2" "hsa:22868; Q9NVX6; Q9NYY8; Q9Y2H7" "" "FASTK family proteins regulate processing and stability of mitochondrial RNAs" "1" "0" "1.042" "1.079" "1.111" "1.122" "1.115" "1.099" "1.128" "1.070" "1.104" "613.1" "638.9" "661.8" "681.0" "687.9" "683.4" "673.6" "691.3" "656.1" "676.7" "" "" "" "" "" "" "" "" "" "" "574.5" "528.7" "614.4" "526.4" "586.4" "652.9" "615.5" "613.8" "656.1" "651.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-94552620576090045" "False" "High" "IsMasterProtein" "Q8IYM9" "E3 ubiquitin-protein ligase TRIM22 OS=Homo sapiens OX=9606 GN=TRIM22 PE=1 SV=1" "0.000" "False" "21.359" "14" "7" "10" "7" "498" "56.9" "7.72" "32.17" "7" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13445" "10346" "ENSG00000132274" "TRIM22" "hsa:10346; Q05CQ0; Q15521; Q8IYM9" "" "Interferon gamma signaling" "1" "0" "0.984" "0.997" "1.024" "1.032" "1.011" "1.026" "1.019" "1.004" "1.003" "1160.0" "1141.7" "1156.6" "1187.2" "1197.1" "1172.2" "1190.1" "1182.5" "1165.0" "1163.7" "" "" "" "" "" "" "" "" "" "" "1086.9" "944.7" "1073.8" "917.8" "1020.4" "1119.9" "1087.4" "1049.9" "1165.0" "1120.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6205796797264401430" "False" "High" "IsMasterProtein" "Q96DH6" "RNA-binding protein Musashi homolog 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1" "0.000" "False" "21.339" "24" "6" "7" "6" "328" "35.2" "8.48" "23.47" "6" "developmental processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "124540" "ENSG00000153944" "MSI2" "hsa:124540; Q7Z6M7; Q8N9T4; Q96DH6" "" "RHOBTB2 GTPase cycle" "1" "0" "0.953" "1.039" "0.930" "1.028" "1.018" "0.935" "0.956" "0.981" "0.973" "750.9" "715.6" "780.0" "698.2" "771.9" "764.7" "701.9" "718.2" "736.7" "730.8" "" "" "" "" "" "" "" "" "" "" "703.6" "592.1" "724.2" "539.7" "657.9" "730.6" "641.4" "637.7" "736.7" "703.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "272489793728892869" "False" "High" "IsMasterProtein" "Q14696" "LRP chaperone MESD OS=Homo sapiens OX=9606 GN=MESD PE=1 SV=2" "0.000" "False" "21.330" "32" "8" "12" "8" "234" "26.1" "7.78" "36.34" "8" "cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf10185" "23184" "ENSG00000117899" "MESD" "B4DW84; D3DW96; hsa:23184; Q14696; Q969U1" "" "" "0" "0" "1.066" "0.978" "0.956" "0.982" "0.941" "0.958" "0.959" "0.967" "0.964" "1810.5" "1930.7" "1770.4" "1730.0" "1777.8" "1703.8" "1734.9" "1736.4" "1750.7" "1744.8" "" "" "" "" "" "" "" "" "" "" "1696.4" "1597.7" "1643.6" "1337.4" "1515.4" "1627.8" "1585.2" "1541.7" "1750.7" "1680.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5373690399274413822" "False" "High" "IsMasterProtein" "Q8N543" "Prolyl 3-hydroxylase OGFOD1 OS=Homo sapiens OX=9606 GN=OGFOD1 PE=1 SV=1" "0.000" "False" "21.320" "15" "7" "11" "7" "542" "63.2" "5.11" "38.19" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf10637, Pf13661" "55239" "ENSG00000087263" "OGFOD1" "H3BUQ2; hsa:55239; Q8N543; Q9H7U5; Q9H9J9; Q9HA87; Q9HCG0; Q9NVB6" "" "Protein hydroxylation" "1" "0" "0.964" "0.953" "1.025" "0.940" "1.031" "0.980" "0.978" "0.980" "0.981" "1147.8" "1106.0" "1093.3" "1176.4" "1078.8" "1183.6" "1124.5" "1122.6" "1124.8" "1126.3" "" "" "" "" "" "" "" "" "" "" "1075.5" "915.2" "1015.0" "909.4" "919.5" "1130.9" "1027.5" "996.8" "1124.8" "1084.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7391762605629829309" "False" "High" "IsMasterProtein" "O95801" "Tetratricopeptide repeat protein 4 OS=Homo sapiens OX=9606 GN=TTC4 PE=1 SV=3" "0.000" "False" "21.300" "17" "7" "8" "7" "387" "44.7" "5.60" "27.23" "7" "protein metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf18972" "7268" "ENSG00000243725" "TTC4" "hsa:7268; O95801; Q53Y95; Q5TA96; Q9H3I2" "" "" "0" "0" "0.956" "0.989" "0.914" "0.984" "0.996" "0.912" "0.926" "0.940" "0.960" "1331.4" "1272.4" "1316.2" "1216.8" "1309.7" "1325.6" "1214.2" "1232.4" "1250.9" "1277.9" "" "" "" "" "" "" "" "" "" "" "1247.5" "1052.9" "1221.9" "940.6" "1116.4" "1266.5" "1109.5" "1094.2" "1250.9" "1230.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5729262198654758902" "False" "High" "IsMasterProtein" "O43396" "Thioredoxin-like protein 1 OS=Homo sapiens OX=9606 GN=TXNL1 PE=1 SV=3" "0.000" "False" "21.280" "28" "7" "7" "7" "289" "32.2" "4.96" "23.50" "7" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf00085, Pf06201" "9352" "ENSG00000091164" "TXNL1" "hsa:9352; O43396" "" "RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "7" "0" "0.973" "0.990" "1.003" "0.972" "0.963" "0.983" "0.997" "1.060" "1.019" "863.4" "839.7" "854.5" "865.7" "839.0" "831.3" "848.9" "860.4" "915.4" "880.0" "" "" "" "" "" "" "" "" "" "" "809.0" "694.8" "793.3" "669.3" "715.2" "794.2" "775.6" "763.9" "915.4" "847.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1788576308263676540" "False" "High" "IsMasterProtein" "Q9BUK6" "Protein misato homolog 1 OS=Homo sapiens OX=9606 GN=MSTO1 PE=1 SV=1" "0.000" "False" "21.254" "10" "6" "8" "6" "570" "61.8" "6.11" "26.08" "6" "cell organization and biogenesis" "other membranes;cytosol;mitochondrion;other cell component" "" "Pf10644, Pf14881" "55154" "ENSG00000125459" "MSTO1" "hsa:55154; Q53GR8; Q5CZ69; Q5T717; Q68CT6; Q7LBZ8; Q7Z3M7; Q7Z558; Q8TE05; Q9BUK6; Q9NQX2; Q9NVU4" "" "" "0" "0" "1.008" "1.036" "1.001" "1.050" "1.032" "0.942" "1.003" "1.008" "1.043" "782.0" "787.9" "810.4" "782.4" "821.0" "807.2" "736.5" "784.7" "788.0" "815.8" "" "" "" "" "" "" "" "" "" "" "732.7" "652.0" "752.4" "604.9" "699.8" "771.2" "672.9" "696.7" "788.0" "785.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4476528208765438767" "False" "High" "IsMasterProtein" "Q9Y5S9" "RNA-binding protein 8A OS=Homo sapiens OX=9606 GN=RBM8A PE=1 SV=1" "0.000" "False" "21.253" "32" "6" "13" "6" "174" "19.9" "5.72" "44.29" "6" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "9939" "ENSG00000265241" "RBM8A" "B3KQI9; hsa:9939; Q6FHD1; Q6IQ40; Q9GZX8; Q9NZI4; Q9Y5S9" "" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "6" "0" "1.030" "0.958" "1.004" "1.030" "1.006" "1.120" "1.057" "1.084" "1.011" "1119.2" "1153.0" "1071.8" "1124.1" "1152.7" "1126.5" "1253.3" "1182.8" "1213.4" "1131.9" "" "" "" "" "" "" "" "" "" "" "1048.7" "954.1" "995.0" "869.0" "982.5" "1076.2" "1145.2" "1050.2" "1213.4" "1089.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8900413936480429684" "False" "High" "IsMasterProtein" "Q9Y6I4" "Ubiquitin carboxyl-terminal hydrolase 3 OS=Homo sapiens OX=9606 GN=USP3 PE=1 SV=2" "0.000" "False" "21.231" "14" "6" "8" "6" "520" "58.9" "8.18" "23.06" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00443, Pf02148" "9960" "ENSG00000140455" "USP3" "B4DVU5; F5H1A6; hsa:9960; Q8WVD0; Q9Y6I4" "" "Ub-specific processing proteases" "1" "0" "1.007" "1.043" "1.006" "1.081" "1.032" "1.013" "1.039" "1.001" "1.088" "771.5" "777.2" "804.4" "775.9" "834.3" "796.4" "781.4" "801.6" "772.4" "839.2" "" "" "" "" "" "" "" "" "" "" "722.9" "643.1" "746.8" "599.8" "711.1" "760.8" "714.0" "711.8" "772.4" "808.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2648921608470054018" "False" "High" "IsMasterProtein" "Q96L92" "Sorting nexin-27 OS=Homo sapiens OX=9606 GN=SNX27 PE=1 SV=2" "0.000" "False" "21.229" "14" "7" "9" "7" "541" "61.2" "6.49" "25.61" "7" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00595, Pf00787, Pf00788" "81609" "ENSG00000143376" "SNX27" "hsa:81609; Q32Q36; Q4AEJ5; Q5VWB0; Q5VWB1; Q5VWB2; Q6IPP6; Q86UB1; Q96D79; Q96L92; Q9H3K8" "" "" "0" "0" "1.020" "0.989" "1.048" "1.002" "0.997" "0.994" "0.982" "0.960" "0.988" "1037.3" "1058.6" "1026.4" "1087.0" "1039.5" "1033.8" "1030.7" "1018.8" "995.8" "1024.9" "" "" "" "" "" "" "" "" "" "" "972.0" "876.0" "952.9" "840.3" "886.0" "987.7" "941.8" "904.6" "995.8" "986.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7222850354556005820" "False" "High" "IsMasterProtein" "P20839" "Inosine-5'-monophosphate dehydrogenase 1 OS=Homo sapiens OX=9606 GN=IMPDH1 PE=1 SV=2" "0.000" "False" "21.220" "13" "7" "12" "5" "514" "55.4" "6.90" "38.51" "7" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00478, Pf00571" "3614" "ENSG00000106348" "IMPDH1" "A4D0Z6; A4D0Z7; A6NDW5; A6NNI6; B3KNP7; B3KVM8; B4DE09; C9JV30; hsa:3614; J3KNX8; P20839; Q8N194; Q96NU2" "" "Potential therapeutics for SARS; Azathioprine ADME; Neutrophil degranulation; Purine ribonucleoside monophosphate biosynthesis" "4" "0" "0.954" "0.993" "0.977" "0.951" "0.990" "0.906" "0.932" "0.953" "0.967" "1414.3" "1349.0" "1404.7" "1381.5" "1344.8" "1400.8" "1281.4" "1318.6" "1348.2" "1367.4" "" "" "" "" "" "" "" "" "" "" "1325.2" "1116.3" "1304.1" "1068.0" "1146.3" "1338.3" "1170.9" "1170.8" "1348.2" "1316.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2100681429736934038" "False" "High" "IsMasterProtein" "O95218" "Zinc finger Ran-binding domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZRANB2 PE=1 SV=2" "0.000" "False" "21.212" "18" "6" "7" "6" "330" "37.4" "10.01" "27.58" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00641" "9406" "ENSG00000132485" "ZRANB2" "D3DQ75; hsa:9406; O95218; Q53GS3; Q59F92; Q5VV33; Q5VV34; Q8IXN6; Q9UP63" "" "" "0" "0" "1.123" "1.116" "0.920" "0.955" "0.984" "0.941" "0.974" "1.051" "1.008" "1077.3" "1210.3" "1202.1" "990.9" "1028.7" "1060.6" "1014.2" "1049.4" "1132.4" "1085.4" "" "" "" "" "" "" "" "" "" "" "1009.4" "1001.5" "1116.0" "766.0" "876.8" "1013.3" "926.7" "931.8" "1132.4" "1045.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8309198551146026693" "False" "High" "IsMasterProtein" "O15226" "NF-kappa-B-repressing factor OS=Homo sapiens OX=9606 GN=NKRF PE=1 SV=2" "0.000" "False" "21.209" "9" "7" "7" "7" "690" "77.6" "8.79" "23.33" "7" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01424, Pf01585" "55922" "ENSG00000186416" "NKRF" "G3V1N1; O15226; Q4VC41; Q9UJ91" "Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway" "" "2" "0" "0.969" "0.987" "1.010" "0.972" "0.885" "0.953" "0.927" "0.874" "0.946" "866.0" "839.0" "854.6" "874.3" "842.1" "766.2" "825.7" "803.2" "756.8" "818.9" "" "" "" "" "" "" "" "" "" "" "811.4" "694.3" "793.4" "675.9" "717.8" "732.1" "754.4" "713.1" "756.8" "788.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7781995361222793159" "False" "High" "IsMasterProtein" "Q9UJX2" "Cell division cycle protein 23 homolog OS=Homo sapiens OX=9606 GN=CDC23 PE=1 SV=3" "0.000" "False" "21.193" "11" "7" "8" "7" "597" "68.8" "7.02" "21.71" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04049" "8697" "ENSG00000094880" "CDC23" "A8K6E5; B4E3A2; B7WP05; D3DQB7; hsa:8697; O75433; Q53FN2; Q9BS73; Q9UJX2" "Cell cycle" "Separation of Sister Chromatids; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "1.005" "1.033" "1.053" "0.999" "0.924" "0.958" "0.876" "0.920" "0.990" "248.8" "250.2" "257.0" "261.9" "248.5" "229.9" "238.3" "218.1" "228.9" "246.4" "" "" "" "" "" "" "" "" "" "" "233.2" "207.0" "238.6" "202.5" "211.8" "219.6" "217.8" "193.6" "228.9" "237.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6330757226080927514" "False" "High" "IsMasterProtein" "P67775" "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP2CA PE=1 SV=1" "0.000" "False" "21.180" "25" "7" "18" "1" "309" "35.6" "5.54" "59.25" "7" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00149" "5515" "ENSG00000113575" "PPP2CA" "hsa:5515; P05323; P13197; P67775" "Sphingolipid pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Dopamine metabolism; Mesodermal commitment pathway; Mesodermal commitment pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Cancer immunotherapy by CTLA4 blockade; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; CTLA4 inhibitory signaling; Cyclin A/B1/B2 associated events during G2/M transition; DARPP-32 events; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; PKR-mediated signaling; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Negative regulation of MAPK pathway; Platelet sensitization by LDL; Inhibition of replication initiation of damaged DNA by RB1/E2F1; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "53" "0" "0.941" "0.914" "0.819" "0.915" "0.955" "0.883" "0.876" "0.912" "0.910" "1037.6" "976.1" "948.7" "849.9" "949.9" "991.0" "916.0" "909.1" "945.8" "943.9" "" "" "" "" "" "" "" "" "" "" "972.2" "807.7" "880.8" "657.0" "809.7" "946.8" "837.0" "807.2" "945.8" "908.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2530096589731876058" "False" "High" "IsMasterProtein" "Q96EK5" "KIF-binding protein OS=Homo sapiens OX=9606 GN=KIFBP PE=1 SV=1" "0.000" "False" "21.172" "13" "7" "11" "6" "621" "71.8" "5.49" "32.52" "7" "cell organization and biogenesis;transport;developmental processes" "cytoskeleton;mitochondrion" "cytoskeletal activity" "Pf12309" "26128" "ENSG00000198954" "KIFBP" "A8K5M8; Q96EK5; Q9BR89; Q9ULE1; Q9Y428" "" "" "0" "0" "0.994" "0.960" "0.988" "1.012" "1.012" "0.965" "0.964" "0.967" "1.026" "617.9" "614.3" "593.2" "610.5" "625.6" "625.5" "596.1" "595.9" "597.2" "634.2" "" "" "" "" "" "" "" "" "" "" "579.0" "508.3" "550.7" "471.9" "533.2" "597.6" "544.6" "529.1" "597.2" "610.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5117695276373963239" "False" "High" "IsMasterProtein" "Q9UKL0" "REST corepressor 1 OS=Homo sapiens OX=9606 GN=RCOR1 PE=1 SV=2" "0.000" "False" "21.166" "15" "8" "10" "5" "485" "53.3" "7.03" "30.68" "8" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf20878" "23186" "ENSG00000089902" "RCOR1" "hsa:23186; J3KN32; Q15044; Q6P2I9; Q86VG5; Q9UKL0" "" "Regulation of PTEN gene transcription; Potential therapeutics for SARS; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production" "4" "0" "0.973" "0.941" "0.919" "0.952" "0.957" "1.020" "0.894" "0.968" "0.947" "835.1" "812.9" "785.8" "767.3" "795.3" "799.0" "851.7" "746.3" "808.7" "790.9" "" "" "" "" "" "" "" "" "" "" "782.5" "672.6" "729.5" "593.2" "677.9" "763.3" "778.3" "662.6" "808.7" "761.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7705238959085991770" "False" "High" "IsMasterProtein" "P08865" "Small ribosomal subunit protein uS2 OS=Homo sapiens OX=9606 GN=RPSA PE=1 SV=4" "0.000" "False" "21.152" "23" "7" "9" "7" "295" "32.8" "4.87" "32.46" "7" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;translational apparatus;nucleus;other cell component" "translation activity;other molecular function" "Pf00318, Pf16122" "3921" "ENSG00000168028" "RPSA" "hsa:3921; P08865; P11085; P12030; Q16471; Q6IPD1; Q6IPD2; Q6NSD1; Q6NXQ8; Q86VC0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.142" "1.158" "1.156" "1.118" "1.163" "1.318" "1.352" "1.293" "1.163" "1687.9" "1928.3" "1954.3" "1951.6" "1887.8" "1963.3" "2224.9" "2281.7" "2182.6" "1962.3" "" "" "" "" "" "" "" "" "" "" "1581.6" "1595.6" "1814.3" "1508.7" "1609.1" "1875.8" "2033.0" "2025.9" "2182.6" "1889.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "652466818170242457" "False" "High" "IsMasterProtein" "Q9H993" "Damage-control phosphatase ARMT1 OS=Homo sapiens OX=9606 GN=ARMT1 PE=1 SV=1" "0.000" "False" "21.143" "14" "8" "14" "8" "441" "51.1" "5.76" "39.49" "8" "other metabolic processes;stress response" "" "other molecular function" "Pf01937" "79624" "ENSG00000146476" "ARMT1" "hsa:79624; Q96FC6; Q9H993; Q9UFY5" "" "" "0" "0" "0.987" "0.991" "0.999" "1.074" "0.979" "0.972" "1.068" "1.054" "0.994" "729.6" "719.9" "723.1" "728.9" "783.3" "714.5" "709.2" "779.3" "768.8" "725.1" "" "" "" "" "" "" "" "" "" "" "683.6" "595.7" "671.3" "563.4" "667.6" "682.6" "648.0" "691.9" "768.8" "698.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2091961222017639990" "False" "High" "IsMasterProtein" "Q13123" "Protein Red OS=Homo sapiens OX=9606 GN=IK PE=1 SV=3" "0.000" "False" "21.142" "15" "7" "8" "7" "557" "65.6" "6.64" "22.87" "7" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07807, Pf07808" "3550" "ENSG00000113141" "IK" "hsa:3550; Q13123; Q6IPD8" "" "mRNA Splicing - Major Pathway" "1" "0" "1.074" "1.033" "1.129" "1.171" "1.164" "1.254" "1.404" "1.371" "1.177" "473.3" "508.5" "489.2" "534.6" "554.4" "550.9" "593.5" "664.5" "649.1" "557.1" "" "" "" "" "" "" "" "" "" "" "443.5" "420.8" "454.1" "413.3" "472.6" "526.3" "542.3" "590.0" "649.1" "536.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6944601348442643793" "False" "High" "IsMasterProtein" "Q460N5" "Protein mono-ADP-ribosyltransferase PARP14 OS=Homo sapiens OX=9606 GN=PARP14 PE=1 SV=3" "0.000" "False" "21.099" "3" "7" "7" "7" "1801" "202.7" "7.18" "20.56" "7" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00644, Pf01661, Pf02825" "54625" "ENSG00000173193" "PARP14" "B4E2H0; hsa:54625; Q460N4; Q460N5; Q8J027; Q9H9X9; Q9NV60; Q9ULF2" "" "Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein" "3" "0" "1.018" "1.042" "1.112" "1.046" "1.042" "0.964" "0.995" "0.966" "1.013" "471.0" "479.7" "491.0" "523.8" "492.9" "490.8" "453.9" "468.8" "454.8" "477.2" "" "" "" "" "" "" "" "" "" "" "441.4" "396.9" "455.8" "404.9" "420.1" "468.9" "414.8" "416.2" "454.8" "459.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8133999276561542569" "False" "High" "IsMasterProtein" "Q86X55" "Histone-arginine methyltransferase CARM1 OS=Homo sapiens OX=9606 GN=CARM1 PE=1 SV=3" "0.000" "False" "21.085" "11" "7" "16" "7" "608" "65.8" "6.73" "44.38" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06325, Pf11531" "10498" "ENSG00000142453" "CARM1" "A6NN38; hsa:10498; Q86X55" "Androgen receptor signaling pathway; Nitric oxide metabolism in cystic fibrosis" "Estrogen-dependent gene expression; Heme signaling; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; RMTs methylate histone arginines; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Activation of gene expression by SREBF (SREBP); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; RORA activates gene expression" "15" "0" "0.965" "1.028" "1.008" "1.010" "1.048" "1.026" "1.062" "1.038" "1.040" "1103.7" "1065.6" "1134.7" "1112.4" "1114.7" "1156.9" "1132.9" "1171.8" "1146.1" "1147.4" "" "" "" "" "" "" "" "" "" "" "1034.1" "881.7" "1053.5" "859.9" "950.2" "1105.3" "1035.1" "1040.4" "1146.1" "1104.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8260610778738387308" "False" "High" "IsMasterProtein" "Q13907" "Isopentenyl-diphosphate Delta-isomerase 1 OS=Homo sapiens OX=9606 GN=IDI1 PE=1 SV=2" "0.000" "False" "21.077" "27" "5" "13" "5" "227" "26.3" "6.34" "40.40" "5" "other metabolic processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00293" "3422" "ENSG00000067064" "IDI1" "B4E155; hsa:3422; Q13907; Q32Q13; Q53GQ6; Q86U81; Q8WUX8; Q96IZ4; Q9BQ74" "Target of rapamycin signaling; Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Exercise-induced circadian regulation; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "11" "0" "0.883" "0.940" "0.884" "0.889" "0.990" "0.821" "0.880" "0.824" "0.880" "1379.3" "1217.8" "1296.3" "1218.7" "1225.6" "1366.0" "1132.4" "1213.9" "1137.0" "1213.6" "" "" "" "" "" "" "" "" "" "" "1292.4" "1007.7" "1203.5" "942.1" "1044.7" "1305.1" "1034.8" "1077.8" "1137.0" "1168.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2063418146080875135" "False" "High" "IsMasterProtein" "O76094" "Signal recognition particle subunit SRP72 OS=Homo sapiens OX=9606 GN=SRP72 PE=1 SV=3" "0.000" "False" "21.074" "10" "7" "7" "7" "671" "74.6" "9.26" "22.80" "7" "other biological processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08492, Pf13181, Pf17004" "6731" "ENSG00000174780" "SRP72" "G5E9Z8; hsa:6731; O76094; Q7Z3C0" "" "SRP-dependent cotranslational protein targeting to membrane" "1" "0" "0.989" "1.019" "0.880" "0.966" "0.971" "0.974" "0.938" "0.968" "0.988" "1358.5" "1344.1" "1384.7" "1195.3" "1312.0" "1318.4" "1323.5" "1274.9" "1314.6" "1342.5" "" "" "" "" "" "" "" "" "" "" "1272.9" "1112.2" "1285.5" "924.0" "1118.3" "1259.6" "1209.4" "1132.0" "1314.6" "1292.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "718795190937465911" "False" "High" "IsMasterProtein" "Q9Y6V7" "Probable ATP-dependent RNA helicase DDX49 OS=Homo sapiens OX=9606 GN=DDX49 PE=1 SV=1" "0.000" "False" "21.065" "11" "6" "10" "6" "483" "54.2" "9.06" "30.34" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00270, Pf00271" "54555" "ENSG00000105671" "DDX49" "E7ENA0; hsa:54555; Q53FJ1; Q9BVQ8; Q9Y6V7" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.014" "1.027" "1.099" "1.089" "1.114" "1.105" "1.070" "1.073" "1.080" "762.3" "773.1" "782.7" "837.5" "830.3" "849.1" "842.6" "815.8" "817.8" "823.3" "" "" "" "" "" "" "" "" "" "" "714.2" "639.7" "726.6" "647.5" "707.7" "811.3" "769.9" "724.3" "817.8" "792.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3455107625301328378" "False" "High" "IsMasterProtein" "Q86TX2" "Acyl-coenzyme A thioesterase 1 OS=Homo sapiens OX=9606 GN=ACOT1 PE=1 SV=1" "0.000" "False" "21.065" "19" "6" "8" "6" "421" "46.2" "7.34" "28.17" "6" "other metabolic processes" "cytosol" "other molecular function" "Pf04775, Pf08840" "641371" "ENSG00000184227" "ACOT1" "A1L173; hsa:641371; Q3I5F9; Q86TX2" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "0.942" "0.970" "1.069" "1.043" "0.965" "1.013" "1.017" "0.992" "1.001" "976.8" "920.4" "947.2" "1044.6" "1019.0" "942.9" "989.6" "993.1" "968.5" "977.4" "" "" "" "" "" "" "" "" "" "" "915.3" "761.6" "879.4" "807.5" "868.6" "900.9" "904.3" "881.7" "968.5" "941.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5652350861994780505" "False" "High" "IsMasterProtein" "Q13480" "GRB2-associated-binding protein 1 OS=Homo sapiens OX=9606 GN=GAB1 PE=1 SV=2" "0.000" "False" "21.062" "12" "6" "6" "6" "694" "76.6" "5.96" "20.06" "6" "developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00169" "2549" "ENSG00000109458" "GAB1" "A8K152; hsa:2549; Q13480; Q4W5G2; Q6P1W2" "Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Alpha 6 beta 4 signaling pathway; Hepatocyte growth factor receptor signaling; IL6 signaling pathway; BDNF-TrkB signaling; VEGFA-VEGFR2 signaling; Embryonic stem cell pluripotency pathways; MET in type 1 papillary renal cell carcinoma; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; GDNF signaling; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; ErbB signaling pathway" "Signaling by FGFR1 in disease; PIP3 activates AKT signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Constitutive Signaling by Aberrant PI3K in Cancer; MET activates RAP1 and RAC1; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); PI3K Cascade; PI3K events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; GAB1 signalosome; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; Signaling by FGFR2 in disease; PI-3K cascade:FGFR3; PI-3K cascade:FGFR4; Signaling by FGFR3 in disease; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; MET activates PI3K/AKT signaling; MET activates PTPN11; MET receptor recycling; Activated NTRK2 signals through PI3K" "46" "0" "0.974" "0.935" "0.944" "0.985" "0.940" "0.941" "0.901" "0.872" "0.888" "623.0" "606.8" "582.7" "588.4" "613.6" "585.6" "586.1" "561.3" "543.5" "553.0" "" "" "" "" "" "" "" "" "" "" "583.7" "502.1" "541.0" "454.8" "523.0" "559.5" "535.6" "498.3" "543.5" "532.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1675638052339020088" "False" "High" "IsMasterProtein" "O75146" "Huntingtin-interacting protein 1-related protein OS=Homo sapiens OX=9606 GN=HIP1R PE=1 SV=2" "0.000" "False" "21.055" "6" "7" "7" "7" "1068" "119.3" "6.67" "24.23" "7" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf01608, Pf07651, Pf16515" "9026" "ENSG00000130787" "HIP1R" "A6NHQ6; hsa:9026; O75146; Q6NXG8; Q9UED9" "5q35 copy number variation" "Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis" "3" "0" "1.057" "1.015" "1.118" "1.103" "1.017" "1.091" "1.056" "1.060" "1.074" "655.9" "692.9" "665.7" "733.0" "723.2" "666.8" "715.7" "692.8" "695.5" "704.4" "" "" "" "" "" "" "" "" "" "" "614.5" "573.4" "618.0" "566.7" "616.5" "637.1" "653.9" "615.1" "695.5" "678.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5897019344324903703" "False" "High" "IsMasterProtein" "Q9NP79" "Vacuolar protein sorting-associated protein VTA1 homolog OS=Homo sapiens OX=9606 GN=VTA1 PE=1 SV=1" "0.000" "False" "21.042" "20" "6" "11" "6" "307" "33.9" "6.29" "30.78" "6" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04652, Pf18097" "51534" "ENSG00000009844" "VTA1" "B4DW55; E1P594; E7ETQ7; hsa:51534; Q5TGM1; Q6IAE8; Q9H0R2; Q9H3K9; Q9NP79; Q9P0Q0" "" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "2" "0" "0.987" "0.995" "1.009" "0.991" "1.047" "0.990" "0.999" "0.960" "0.996" "921.3" "909.2" "916.4" "929.9" "912.7" "964.4" "912.2" "920.3" "884.6" "917.6" "" "" "" "" "" "" "" "" "" "" "863.3" "752.3" "850.8" "718.8" "778.0" "921.4" "833.5" "817.1" "884.6" "883.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "978357741075337008" "False" "High" "IsMasterProtein" "Q6UN15" "Pre-mRNA 3'-end-processing factor FIP1 OS=Homo sapiens OX=9606 GN=FIP1L1 PE=1 SV=1" "0.000" "False" "21.035" "14" "6" "8" "6" "594" "66.5" "5.59" "26.85" "6" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf05182" "81608" "ENSG00000145216" "FIP1L1" "B4DIR3; G3XAD6; hsa:81608; Q0VGE0; Q499Y4; Q49AU3; Q6UN15; Q7Z608; Q8WVN3; Q96F80; Q9H077" "" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins" "6" "0" "0.780" "0.794" "0.786" "0.917" "0.997" "1.086" "1.171" "1.158" "0.943" "596.1" "465.1" "473.0" "468.6" "546.8" "594.1" "647.6" "697.8" "690.4" "561.9" "" "" "" "" "" "" "" "" "" "" "558.5" "384.8" "439.1" "362.2" "466.1" "567.6" "591.7" "619.6" "690.4" "541.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4941414792679987409" "False" "High" "IsMasterProtein" "Q00403" "Transcription initiation factor IIB OS=Homo sapiens OX=9606 GN=GTF2B PE=1 SV=1" "0.000" "False" "21.031" "25" "6" "6" "6" "316" "34.8" "8.35" "21.45" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00382, Pf08271" "2959" "ENSG00000137947" "GTF2B" "A8K1A7; hsa:2959; Q00403; Q5JS30" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "10" "0" "1.100" "1.093" "1.118" "1.111" "1.055" "1.045" "1.019" "0.994" "1.071" "492.8" "542.0" "538.5" "550.8" "547.7" "519.7" "515.1" "502.1" "490.1" "527.9" "" "" "" "" "" "" "" "" "" "" "461.8" "448.5" "499.9" "425.8" "466.9" "496.6" "470.7" "445.8" "490.1" "508.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7020268087964795198" "False" "High" "IsMasterProtein" "Q9Y3B7" "Large ribosomal subunit protein uL11m OS=Homo sapiens OX=9606 GN=MRPL11 PE=1 SV=1" "0.000" "False" "21.014" "42" "8" "9" "8" "192" "20.7" "9.91" "27.03" "8" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00298, Pf03946" "65003" "ENSG00000174547" "MRPL11" "A6NLT0; A8K219; hsa:65003; Q32P46; Q96Q73; Q9Y3B7" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.986" "1.016" "1.047" "1.067" "1.155" "1.043" "1.023" "1.040" "1.061" "508.5" "501.2" "516.7" "532.6" "542.5" "587.2" "530.3" "520.4" "528.9" "539.4" "" "" "" "" "" "" "" "" "" "" "476.4" "414.7" "479.7" "411.7" "462.4" "561.0" "484.5" "462.0" "528.9" "519.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4696526329741067639" "False" "High" "IsMasterProtein" "Q14344" "Guanine nucleotide-binding protein subunit alpha-13 OS=Homo sapiens OX=9606 GN=GNA13 PE=1 SV=2" "0.000" "False" "20.978" "19" "7" "8" "6" "377" "44.0" "8.00" "24.16" "7" "stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00503" "10672" "ENSG00000120063" "GNA13" "B2R977; B7Z7R0; F5H1G8; hsa:10672; Q14344; Q8TD70" "Thyroid stimulating hormone (TSH) signaling pathway; G protein signaling pathways; Modulators of TCR signaling and T cell activation; Regulation of actin cytoskeleton; G13 signaling pathway" "G alpha (12/13) signalling events; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; Thrombin signalling through proteinase activated receptors (PARs); Thromboxane signalling through TP receptor" "11" "1" "0.894" "0.956" "0.972" "0.931" "0.891" "0.868" "0.891" "0.876" "0.911" "859.7" "768.6" "821.7" "835.6" "800.1" "766.3" "745.9" "766.4" "753.3" "783.2" "" "" "" "" "" "" "" "" "" "" "805.5" "636.0" "762.8" "645.9" "682.0" "732.2" "681.5" "680.5" "753.3" "754.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1466786555444396810" "False" "High" "IsMasterProtein" "Q12933" "TNF receptor-associated factor 2 OS=Homo sapiens OX=9606 GN=TRAF2 PE=1 SV=2" "0.000" "False" "20.933" "15" "8" "9" "8" "501" "55.8" "7.53" "25.56" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00097, Pf02176, Pf16673, Pf21341, Pf21355" "7186" "ENSG00000127191" "TRAF2" "A8K107; B4DPJ7; hsa:7186; Q12933; Q7Z337; Q96NT2" "RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Apoptosis; Photodynamic therapy-induced AP-1 survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Oxidative damage response; p38 MAPK signaling pathway; Nonalcoholic fatty liver disease; Small cell lung cancer; 16p11.2 proximal deletion syndrome; 16p11.2 distal deletion syndrome; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Pleural mesothelioma; Alzheimer's disease; 1p36 copy number variation syndrome; 13q12.12 copy number variation; 8q11.23 (RB1CC1) copy number variation" "Ub-specific processing proteases; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TRAF6 mediated NF-kB activation; Regulation of NF-kappa B signaling; TNFR1-induced proapoptotic signaling; TRAF6 mediated IRF7 activation; Defective RIPK1-mediated regulated necrosis" "37" "0" "1.088" "1.031" "1.061" "1.061" "1.025" "0.983" "1.058" "1.053" "1.030" "499.8" "543.8" "515.4" "530.1" "530.3" "512.1" "491.1" "528.6" "526.4" "514.9" "" "" "" "" "" "" "" "" "" "" "468.3" "450.0" "478.5" "409.8" "452.0" "489.3" "448.7" "469.4" "526.4" "495.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5340528139668487905" "False" "High" "IsMasterProtein" "O95831" "Apoptosis-inducing factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=AIFM1 PE=1 SV=1" "0.000" "False" "20.928" "12" "6" "10" "6" "613" "66.9" "8.95" "34.32" "6" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00070, Pf14721" "9131" "ENSG00000156709" "AIFM1" "A4QPB4; B1ALN1; B2RB08; D3DTE9; E9PRR0; O95831; Q1L6K4; Q1L6K6; Q2QKE4; Q5JUZ7; Q6I9X6; Q9Y3I3; Q9Y3I4" "Apoptosis modulation and signaling; Nanomaterial induced apoptosis; Apoptosis modulation by HSP70" "" "3" "0" "1.062" "1.108" "1.122" "1.193" "1.229" "1.300" "1.301" "1.216" "1.141" "527.4" "559.9" "584.5" "591.6" "629.1" "648.5" "685.8" "686.2" "641.4" "601.8" "" "" "" "" "" "" "" "" "" "" "494.2" "463.3" "542.6" "457.3" "536.2" "619.6" "626.6" "609.2" "641.4" "579.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6985960340352969870" "False" "High" "IsMasterProtein" "P62714" "Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PPP2CB PE=1 SV=1" "0.000" "False" "20.927" "25" "7" "17" "1" "309" "35.6" "5.43" "54.40" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00149" "5516" "ENSG00000104695" "PPP2CB" "D3DSV4; hsa:5516; P11082; P62714; Q6FHK5" "Serotonin transporter activity; Dopamine metabolism; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; Exercise-induced circadian regulation; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; Monoamine transport" "Separation of Sister Chromatids; Regulation of TP53 Degradation; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RAF activation; Negative regulation of MAPK pathway; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; PKR-mediated signaling; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "45" "4" "1.053" "1.018" "1.073" "1.033" "1.064" "1.024" "1.047" "1.000" "0.990" "847.3" "892.1" "862.9" "909.2" "875.1" "901.2" "867.3" "887.1" "847.7" "838.7" "" "" "" "" "" "" "" "" "" "" "793.9" "738.2" "801.1" "702.9" "745.9" "861.0" "792.4" "787.6" "847.7" "807.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8813199514956100081" "False" "High" "IsMasterProtein" "O94822" "E3 ubiquitin-protein ligase listerin OS=Homo sapiens OX=9606 GN=LTN1 PE=1 SV=6" "0.000" "False" "20.925" "4" "7" "8" "7" "1766" "200.4" "6.25" "26.49" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "translation activity;other molecular function" "" "26046" "ENSG00000198862; ENSG00000291534" "LTN1" "A6NL41; A7E2D0; B2RTS0; C9J7U3; J3KPL4; O94822; Q05C47; Q9H8M4; Q9NUY5; Q9P0E9" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.029" "1.053" "1.031" "1.074" "1.118" "0.996" "1.066" "1.026" "1.093" "487.2" "501.2" "513.0" "502.4" "523.2" "544.9" "485.2" "519.5" "499.7" "532.4" "" "" "" "" "" "" "" "" "" "" "456.5" "414.7" "476.3" "388.3" "446.0" "520.6" "443.3" "461.3" "499.7" "512.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8225336690214534054" "False" "High" "IsMasterProtein" "O43768" "Alpha-endosulfine OS=Homo sapiens OX=9606 GN=ENSA PE=1 SV=1" "0.000" "False" "20.917" "48" "5" "10" "4" "121" "13.4" "7.24" "35.97" "5" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf04667" "2029" "ENSG00000143420" "ENSA" "A8K1Z9; E9PB69; hsa:2029; O43768; Q5T5H2; Q68D48; Q6FHW0; Q6IAM4; Q6NUL2; Q6VUC6; Q6VUC7; Q6VUC8; Q6VUC9; Q6VUD0; Q6VUD1; Q9NRZ0" "" "MASTL Facilitates Mitotic Progression" "1" "2" "0.971" "0.981" "0.917" "0.955" "0.913" "0.863" "0.882" "0.833" "0.907" "2185.7" "2121.3" "2143.9" "2004.1" "2086.2" "1995.1" "1886.3" "1927.7" "1821.0" "1981.5" "" "" "" "" "" "" "" "" "" "" "2048.0" "1755.4" "1990.3" "1549.3" "1778.3" "1906.1" "1723.6" "1711.6" "1821.0" "1907.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5123694492544734526" "False" "High" "IsMasterProtein" "Q99417" "c-Myc-binding protein OS=Homo sapiens OX=9606 GN=MYCBP PE=1 SV=3" "0.000" "False" "20.916" "46" "5" "7" "5" "103" "12.0" "5.91" "27.09" "5" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "" "26292" "ENSG00000214114" "MYCBP" "B2R4N0; hsa:26292; Q5TA64; Q96HE2; Q99417" "Pathways affected in adenoid cystic carcinoma" "" "1" "0" "0.999" "1.023" "0.954" "1.012" "0.996" "1.000" "1.027" "0.944" "1.036" "1598.7" "1597.1" "1635.1" "1524.6" "1618.2" "1591.8" "1598.0" "1642.0" "1509.5" "1656.7" "" "" "" "" "" "" "" "" "" "" "1498.0" "1321.6" "1517.9" "1178.5" "1379.3" "1520.9" "1460.2" "1457.9" "1509.5" "1595.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7858307060055438950" "False" "High" "IsMasterProtein" "Q9HAB8" "Phosphopantothenate--cysteine ligase OS=Homo sapiens OX=9606 GN=PPCS PE=1 SV=2" "0.000" "False" "20.915" "17" "6" "9" "6" "311" "34.0" "6.71" "29.16" "6" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04127" "79717" "ENSG00000127125" "PPCS" "hsa:79717; Q3KQT2; Q5VVM0; Q9HAB8" "" "Coenzyme A biosynthesis" "1" "0" "0.987" "0.960" "1.154" "1.052" "0.958" "1.045" "0.991" "0.981" "0.955" "573.6" "566.1" "550.9" "661.9" "603.6" "549.7" "599.5" "568.4" "562.5" "547.6" "" "" "" "" "" "" "" "" "" "" "537.5" "468.4" "511.5" "511.6" "514.5" "525.2" "547.8" "504.7" "562.5" "527.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2036187621347807091" "False" "High" "IsMasterProtein" "P23469" "Receptor-type tyrosine-protein phosphatase epsilon OS=Homo sapiens OX=9606 GN=PTPRE PE=1 SV=1" "0.000" "False" "20.876" "10" "7" "7" "7" "700" "80.6" "7.02" "21.32" "7" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00102" "5791" "ENSG00000132334" "PTPRE" "hsa:5791; P23469; Q13345; Q5VWH3; Q5VWH4; Q96KQ6" "" "" "0" "0" "1.041" "0.997" "1.237" "1.083" "0.985" "1.065" "0.999" "0.953" "1.035" "675.4" "702.8" "673.6" "835.2" "731.5" "665.1" "719.1" "674.8" "643.5" "698.9" "" "" "" "" "" "" "" "" "" "" "632.8" "581.6" "625.4" "645.7" "623.5" "635.4" "657.1" "599.2" "643.5" "673.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174641781052764353" "False" "High" "IsMasterProtein" "Q9P2T1" "GMP reductase 2 OS=Homo sapiens OX=9606 GN=GMPR2 PE=1 SV=1" "0.000" "False" "20.873" "19" "7" "10" "7" "348" "37.9" "7.23" "31.65" "7" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00478" "51292" "ENSG00000100938; ENSG00000284752" "GMPR2" "D3DS66; hsa:51292; Q567T0; Q6IAJ8; Q86T14; Q9P2T1" "" "Purine salvage" "1" "0" "0.977" "0.994" "0.940" "0.921" "1.015" "0.879" "0.934" "1.003" "0.965" "1220.9" "1193.3" "1213.5" "1147.7" "1124.0" "1238.9" "1073.8" "1140.4" "1224.2" "1177.7" "" "" "" "" "" "" "" "" "" "" "1144.0" "987.4" "1126.6" "887.2" "958.0" "1183.6" "981.1" "1012.6" "1224.2" "1133.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2958719848471143183" "False" "High" "IsMasterProtein" "P54687" "Branched-chain-amino-acid aminotransferase, cytosolic OS=Homo sapiens OX=9606 GN=BCAT1 PE=1 SV=3" "0.000" "False" "20.857" "13" "5" "10" "5" "386" "42.9" "5.30" "33.32" "5" "cell cycle OR cell proliferation;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01063" "586" "ENSG00000060982" "BCAT1" "B3KY27; B7Z2M5; B7Z5L0; F5H5E4; hsa:586; P54687; Q68DQ7; Q96MY9" "Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways" "Branched-chain amino acid catabolism" "4" "0" "0.853" "0.836" "0.860" "0.856" "0.963" "0.777" "0.892" "0.883" "0.860" "1182.4" "1008.2" "988.3" "1017.4" "1012.4" "1138.8" "919.0" "1054.3" "1043.7" "1016.6" "" "" "" "" "" "" "" "" "" "" "1107.9" "834.3" "917.6" "786.5" "862.9" "1088.0" "839.7" "936.1" "1043.7" "978.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1112180940687261840" "False" "High" "IsMasterProtein" "Q15185" "Prostaglandin E synthase 3 OS=Homo sapiens OX=9606 GN=PTGES3 PE=1 SV=1" "0.000" "False" "20.849" "39" "6" "17" "6" "160" "18.7" "4.54" "52.04" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04969" "10728" "ENSG00000110958" "PTGES3" "A8K7D0; B4DHP2; B4DP11; B4DP21; hsa:10728; Q15185; Q8WU70" "Aryl hydrocarbon receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Omega-6-fatty acids in senescence" "Potential therapeutics for SARS; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Aryl hydrocarbon receptor signalling; Estrogen-dependent gene expression; Synthesis of Prostaglandins (PG) and Thromboxanes (TX); HSF1 activation; Attenuation phase" "12" "0" "1.021" "1.007" "0.930" "1.002" "0.910" "0.991" "0.940" "0.886" "0.970" "721.2" "736.5" "726.0" "670.6" "722.8" "656.6" "714.4" "678.2" "638.8" "699.5" "" "" "" "" "" "" "" "" "" "" "675.8" "609.5" "674.0" "518.4" "616.1" "627.3" "652.7" "602.2" "638.8" "673.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6094529598036827804" "False" "High" "IsMasterProtein" "Q13442" "28 kDa heat- and acid-stable phosphoprotein OS=Homo sapiens OX=9606 GN=PDAP1 PE=1 SV=1" "0.000" "False" "20.846" "36" "7" "9" "7" "181" "20.6" "8.87" "35.28" "7" "signal transduction" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "" "Pf10252" "11333" "ENSG00000106244" "PDAP1" "D6W5S5; hsa:11333; Q13442; Q92906" "" "Neutrophil degranulation" "1" "0" "1.029" "0.879" "0.932" "0.932" "0.842" "0.922" "0.926" "0.861" "0.895" "1670.1" "1718.7" "1468.2" "1557.2" "1556.7" "1406.5" "1540.4" "1546.1" "1437.2" "1494.5" "" "" "" "" "" "" "" "" "" "" "1564.8" "1422.2" "1363.0" "1203.8" "1326.9" "1343.8" "1407.6" "1372.8" "1437.2" "1439.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1699375806796057255" "False" "High" "IsMasterProtein" "Q6IA69" "Glutamine-dependent NAD(+) synthetase OS=Homo sapiens OX=9606 GN=NADSYN1 PE=1 SV=3" "0.000" "False" "20.845" "8" "5" "6" "5" "706" "79.2" "6.44" "19.22" "5" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00795, Pf02540" "55191" "ENSG00000172890" "NADSYN1" "B3KUU4; hsa:55191; Q6IA69; Q86SN2; Q9HA25; Q9NVM8" "NAD biosynthesis II (from tryptophan); NAD+ biosynthetic pathways" "Nicotinate metabolism" "3" "0" "2.335" "0.996" "2.153" "1.193" "0.923" "0.959" "0.933" "0.951" "0.905" "970.4" "2266.0" "966.4" "2089.1" "1157.6" "895.7" "931.0" "905.5" "922.7" "878.3" "" "" "" "" "" "" "" "" "" "" "909.3" "1875.1" "897.2" "1615.0" "986.7" "855.8" "850.7" "804.0" "922.7" "845.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-476306151852591039" "False" "High" "IsMasterProtein" "Q15102" "Platelet-activating factor acetylhydrolase IB subunit alpha1 OS=Homo sapiens OX=9606 GN=PAFAH1B3 PE=1 SV=1" "0.000" "False" "20.815" "29" "7" "14" "7" "231" "25.7" "6.84" "37.65" "7" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13472" "5050" "ENSG00000079462" "PAFAH1B3" "hsa:5050; Q15102; Q53X88" "PAFAH1B1 copy number variation" "COPI-independent Golgi-to-ER retrograde traffic" "2" "0" "1.057" "1.062" "1.123" "1.130" "1.232" "1.117" "1.112" "1.127" "1.118" "467.0" "493.5" "496.0" "524.3" "527.6" "575.6" "521.8" "519.5" "526.4" "522.0" "" "" "" "" "" "" "" "" "" "" "437.6" "408.3" "460.5" "405.3" "449.7" "549.9" "476.8" "461.3" "526.4" "502.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6162368025994279371" "False" "High" "IsMasterProtein" "Q13395" "Probable methyltransferase TARBP1 OS=Homo sapiens OX=9606 GN=TARBP1 PE=1 SV=1" "0.000" "False" "20.812" "5" "8" "8" "8" "1621" "181.6" "7.05" "23.66" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00588" "6894" "ENSG00000059588" "TARBP1" "hsa:6894; Q13395; Q9H581" "" "" "0" "0" "0.998" "0.996" "1.052" "0.984" "1.026" "0.949" "0.869" "0.918" "0.989" "387.6" "386.9" "386.1" "407.5" "381.3" "397.8" "367.6" "336.9" "355.8" "383.5" "" "" "" "" "" "" "" "" "" "" "363.1" "320.1" "358.5" "315.0" "325.0" "380.1" "335.9" "299.1" "355.8" "369.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8162183631045646946" "False" "High" "IsMasterProtein" "Q01085" "Nucleolysin TIAR OS=Homo sapiens OX=9606 GN=TIAL1 PE=1 SV=1" "0.000" "False" "20.809" "21" "6" "10" "4" "375" "41.6" "7.74" "32.10" "6" "cell cycle OR cell proliferation;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "7073" "ENSG00000151923" "TIAL1" "A8K3T0; A8K4L9; hsa:7073; Q01085" "" "FGFR2 alternative splicing" "1" "0" "1.241" "1.069" "1.311" "1.014" "0.962" "0.810" "1.089" "1.091" "1.093" "512.7" "636.3" "547.9" "672.4" "520.1" "493.3" "415.4" "558.4" "559.5" "560.2" "" "" "" "" "" "" "" "" "" "" "480.4" "526.5" "508.7" "519.8" "443.3" "471.3" "379.5" "495.8" "559.5" "539.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9164959202025983104" "False" "High" "IsMasterProtein" "Q9BSJ2" "Gamma-tubulin complex component 2 OS=Homo sapiens OX=9606 GN=TUBGCP2 PE=1 SV=2" "0.000" "False" "20.806" "8" "9" "12" "9" "902" "102.5" "6.84" "35.06" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf04130, Pf17681" "10844" "ENSG00000130640" "TUBGCP2" "B4DM18; B7ZKL8; F5H4E0; F5H4L0; hsa:10844; O43632; Q5VWX7; Q9BSJ2" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "4" "0" "0.915" "0.991" "1.028" "0.960" "1.012" "0.946" "0.931" "0.943" "1.005" "1319.1" "1206.6" "1307.2" "1356.0" "1266.5" "1335.4" "1247.6" "1227.5" "1244.5" "1325.2" "" "" "" "" "" "" "" "" "" "" "1236.0" "998.5" "1213.6" "1048.2" "1079.5" "1275.8" "1140.0" "1089.9" "1244.5" "1276.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6983483800967602038" "False" "High" "IsMasterProtein" "Q9NVM9" "Integrator complex subunit 13 OS=Homo sapiens OX=9606 GN=INTS13 PE=1 SV=2" "0.000" "False" "20.802" "11" "8" "10" "8" "706" "80.2" "6.70" "31.18" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf10221" "55726" "ENSG00000064102" "INTS13" "B4DNK1; hsa:55726; Q86WE2; Q96HM2; Q9BTX2; Q9NTB6; Q9NVM5; Q9NVM9" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.088" "1.057" "1.065" "1.058" "1.094" "1.038" "1.024" "1.042" "1.027" "1110.5" "1208.8" "1174.0" "1182.9" "1175.3" "1214.6" "1152.2" "1137.2" "1156.9" "1140.4" "" "" "" "" "" "" "" "" "" "" "1040.5" "1000.2" "1090.0" "914.5" "1001.8" "1160.4" "1052.8" "1009.7" "1156.9" "1098.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1767684544015944843" "False" "High" "IsMasterProtein" "P14678" "Small nuclear ribonucleoprotein-associated proteins B and B' OS=Homo sapiens OX=9606 GN=SNRPB PE=1 SV=2" "0.000" "False" "20.791" "30" "7" "16" "7" "240" "24.6" "11.19" "32.82" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "6628" "ENSG00000125835" "SNRPB" "hsa:6628; P14678; Q15490; Q6IB35; Q9UIS5" "mRNA processing" "snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "1.106" "1.177" "1.192" "1.067" "1.059" "1.129" "1.164" "1.115" "1.024" "677.7" "749.6" "797.8" "808.1" "723.0" "717.8" "765.0" "788.6" "755.7" "693.9" "" "" "" "" "" "" "" "" "" "" "635.0" "620.3" "740.7" "624.7" "616.3" "685.8" "699.0" "700.2" "755.7" "668.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9155703229501675198" "False" "High" "IsMasterProtein" "P31751" "RAC-beta serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=AKT2 PE=1 SV=2" "0.000" "False" "20.790" "18" "8" "8" "5" "481" "55.7" "6.37" "23.14" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00169, Pf00433" "208" "ENSG00000105221" "AKT2" "B2RBD8; hsa:208; P31751; Q05BV0; Q0VAN0; Q0VAN1; Q68GC0" "AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; S1P receptor signal transduction; Cardiac hypertrophic response; Focal adhesion; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Lipid metabolism pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Congenital generalized lipodystrophy; Familial partial lipodystrophy; Alzheimer's disease; Acute myeloid leukemia; Sildenafil treatment; Female steroid hormones in cardiomyocyte energy metabolism; JAK-STAT signaling in the regulation of beta cells; Osteoarthritic chondrocyte hypertrophy; Artemisinin inhibition of uveal melanoma; ErbB signaling pathway; Toll-like receptor signaling pathway" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; Regulation of TP53 Degradation; CTLA4 inhibitory signaling; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; Deactivation of the beta-catenin transactivating complex; CD28 dependent PI3K/Akt signaling; TP53 Regulates Metabolic Genes; Downregulation of ERBB2:ERBB3 signaling; G beta:gamma signalling through PI3Kgamma; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; AKT phosphorylates targets in the cytosol; Regulation of TP53 Activity through Association with Co-factors; Activation of AKT2; VEGFR2 mediated vascular permeability; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; FLT3 Signaling; Negative regulation of the PI3K/AKT network; Regulation of TP53 Activity through Acetylation; RUNX2 regulates genes involved in cell migration; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry; Activation of BAD and translocation to mitochondria ; AKT-mediated inactivation of FOXO1A; PDE3B signalling; Inhibition of TSC complex formation by PKB" "83" "0" "0.987" "1.049" "0.880" "1.017" "1.079" "0.938" "1.050" "1.024" "1.031" "469.7" "463.5" "492.8" "413.3" "477.8" "507.0" "440.4" "493.3" "481.0" "484.1" "" "" "" "" "" "" "" "" "" "" "440.1" "383.5" "457.5" "319.5" "407.3" "484.4" "402.4" "438.0" "481.0" "466.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9020069583805455300" "False" "High" "IsMasterProtein" "O60234" "Glia maturation factor gamma OS=Homo sapiens OX=9606 GN=GMFG PE=1 SV=1" "0.000" "False" "20.787" "45" "6" "13" "5" "142" "16.8" "5.26" "37.82" "6" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241" "9535" "ENSG00000130755; ENSG00000291873" "GMFG" "hsa:9535; O60234; Q6IB37" "" "Neutrophil degranulation" "1" "0" "1.027" "1.017" "1.039" "1.020" "1.007" "1.081" "0.998" "0.987" "1.004" "558.3" "573.3" "567.7" "580.0" "569.2" "562.1" "603.7" "557.3" "551.0" "560.6" "" "" "" "" "" "" "" "" "" "" "523.1" "474.4" "527.0" "448.3" "485.2" "537.0" "551.6" "494.8" "551.0" "539.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-145222249138625553" "False" "High" "IsMasterProtein" "Q9BYG3" "MKI67 FHA domain-interacting nucleolar phosphoprotein OS=Homo sapiens OX=9606 GN=NIFK PE=1 SV=1" "0.000" "False" "20.775" "28" "6" "7" "6" "293" "34.2" "9.88" "16.50" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf12196" "84365" "ENSG00000155438" "NIFK" "A8K788; hsa:84365; Q8TB66; Q96ED4; Q9BYG3" "" "" "0" "0" "0.927" "1.019" "1.005" "0.971" "1.059" "1.011" "1.154" "1.048" "1.048" "544.7" "504.9" "554.8" "547.4" "528.9" "576.6" "550.9" "628.5" "570.9" "570.7" "" "" "" "" "" "" "" "" "" "" "510.4" "417.8" "515.1" "423.1" "450.9" "550.9" "503.4" "558.1" "570.9" "549.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6652011194005899795" "False" "High" "IsMasterProtein" "P29083" "General transcription factor IIE subunit 1 OS=Homo sapiens OX=9606 GN=GTF2E1 PE=1 SV=2" "0.000" "False" "20.764" "22" "9" "11" "9" "439" "49.4" "4.82" "24.22" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf02002, Pf08271, Pf11521" "2960" "ENSG00000153767" "GTF2E1" "hsa:2960; P29083; Q16103" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "10" "0" "1.024" "0.958" "0.985" "1.032" "1.056" "1.037" "1.031" "1.061" "1.050" "332.3" "340.3" "318.5" "327.5" "343.1" "350.9" "344.6" "342.6" "352.5" "349.0" "" "" "" "" "" "" "" "" "" "" "311.4" "281.6" "295.7" "253.1" "292.4" "335.3" "314.9" "304.2" "352.5" "336.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3589965409300637784" "False" "High" "IsMasterProtein" "Q14691" "DNA replication complex GINS protein PSF1 OS=Homo sapiens OX=9606 GN=GINS1 PE=1 SV=1" "0.000" "False" "20.734" "28" "5" "9" "5" "196" "23.0" "7.39" "28.71" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes" "nucleus;other cell component" "" "Pf05916" "9837" "ENSG00000101003" "GINS1" "hsa:9837; Q14691; Q9NQE2; Q9NQI7" "" "Unwinding of DNA" "1" "0" "1.096" "1.004" "1.016" "1.066" "1.032" "0.978" "1.023" "1.010" "1.015" "330.2" "361.9" "331.4" "335.6" "352.0" "340.8" "322.9" "337.9" "333.6" "335.0" "" "" "" "" "" "" "" "" "" "" "309.4" "299.5" "307.7" "259.4" "300.0" "325.6" "295.0" "300.0" "333.6" "322.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8624164927491725104" "False" "High" "IsMasterProtein" "O75449" "Katanin p60 ATPase-containing subunit A1 OS=Homo sapiens OX=9606 GN=KATNA1 PE=1 SV=1" "0.000" "False" "20.726" "15" "7" "7" "7" "491" "55.9" "6.90" "23.57" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00004, Pf09336, Pf17862, Pf21126" "11104" "ENSG00000186625" "KATNA1" "E1P5A3; hsa:11104; O75449; Q5TFA8; Q5TFA9; Q86VN2; Q9NU52" "" "" "0" "0" "0.969" "1.027" "0.969" "1.011" "1.047" "0.965" "0.953" "1.031" "0.996" "1684.7" "1632.8" "1731.0" "1631.7" "1703.8" "1763.5" "1625.0" "1605.1" "1736.7" "1677.2" "" "" "" "" "" "" "" "" "" "" "1578.6" "1351.1" "1607.0" "1261.4" "1452.3" "1684.9" "1484.8" "1425.2" "1736.7" "1614.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-700726988884900620" "False" "High" "IsMasterProtein" "Q9BQ61" "Telomerase RNA component interacting RNase OS=Homo sapiens OX=9606 GN=TRIR PE=1 SV=1" "0.000" "False" "20.713" "40" "6" "8" "6" "176" "18.4" "9.44" "30.88" "6" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "" "79002" "ENSG00000123144" "TRIR" "hsa:79002; Q9BQ61" "" "" "0" "0" "1.066" "1.029" "1.001" "1.078" "0.999" "0.978" "1.023" "1.020" "1.009" "929.8" "991.2" "956.8" "930.4" "1002.7" "928.6" "909.2" "951.0" "948.0" "937.9" "" "" "" "" "" "" "" "" "" "" "871.2" "820.2" "888.3" "719.3" "854.7" "887.2" "830.8" "844.4" "948.0" "903.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1866908035804814240" "False" "High" "IsMasterProtein" "P22059" "Oxysterol-binding protein 1 OS=Homo sapiens OX=9606 GN=OSBP PE=1 SV=1" "0.000" "False" "20.702" "8" "6" "11" "6" "807" "89.4" "7.30" "35.14" "6" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "5007" "ENSG00000110048" "OSBP" "hsa:5007; P22059; Q6P524" "" "Sphingolipid de novo biosynthesis; Synthesis of bile acids and bile salts" "2" "0" "0.891" "1.005" "0.903" "0.947" "0.948" "0.949" "0.865" "0.930" "0.995" "995.6" "887.5" "1001.0" "899.0" "942.4" "944.2" "944.4" "860.8" "926.3" "990.6" "" "" "" "" "" "" "" "" "" "" "932.9" "734.4" "929.3" "695.0" "803.3" "902.1" "862.9" "764.3" "926.3" "953.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4632135778776149030" "False" "High" "IsMasterProtein" "P18085" "ADP-ribosylation factor 4 OS=Homo sapiens OX=9606 GN=ARF4 PE=1 SV=3" "0.000" "False" "20.694" "30" "5" "9" "3" "180" "20.5" "7.14" "28.76" "5" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00025" "378" "ENSG00000168374" "ARF4" "B2R7J7; hsa:378; P18085; P21371" "VEGFA-VEGFR2 signaling" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; VxPx cargo-targeting to cilium" "4" "0" "1.074" "1.102" "1.071" "1.097" "1.279" "1.056" "1.114" "1.129" "1.085" "245.9" "264.1" "270.9" "263.4" "269.7" "314.4" "259.6" "273.8" "277.6" "266.7" "" "" "" "" "" "" "" "" "" "" "230.4" "218.5" "251.5" "203.6" "229.9" "300.4" "237.2" "243.1" "277.6" "256.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3812741614734953835" "False" "High" "IsMasterProtein" "Q7L9L4" "MOB kinase activator 1B OS=Homo sapiens OX=9606 GN=MOB1B PE=1 SV=3" "0.000" "False" "20.604" "25" "5" "10" "5" "216" "25.1" "6.73" "29.11" "5" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03637" "92597" "ENSG00000173542" "MOB1B" "B2R8U6; B4DRY3; hsa:92597; Q7L9L4; Q8IY23" "Pleural mesothelioma" "Signaling by Hippo" "2" "0" "0.938" "1.026" "0.917" "0.941" "1.030" "0.943" "1.005" "1.030" "0.998" "719.6" "675.2" "738.1" "659.9" "676.9" "741.5" "678.6" "723.1" "741.0" "718.3" "" "" "" "" "" "" "" "" "" "" "674.3" "558.8" "685.3" "510.1" "577.0" "708.4" "620.1" "642.1" "741.0" "691.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "508361359361041752" "False" "High" "IsMasterProtein" "O00193" "Small acidic protein OS=Homo sapiens OX=9606 GN=SMAP PE=1 SV=1" "0.000" "False" "20.602" "40" "5" "8" "5" "183" "20.3" "4.72" "27.44" "5" "" "" "" "Pf15477" "10944" "ENSG00000110696" "SMAP" "B2RD28; hsa:10944; O00193" "" "" "0" "0" "1.065" "1.056" "0.960" "0.971" "0.962" "0.994" "0.966" "0.939" "0.993" "494.9" "527.0" "522.8" "475.0" "480.6" "476.0" "491.8" "478.2" "464.4" "491.4" "" "" "" "" "" "" "" "" "" "" "463.7" "436.1" "485.4" "367.2" "409.6" "454.8" "449.4" "424.6" "464.4" "473.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4838568104168178339" "False" "High" "IsMasterProtein" "Q8TBC4" "NEDD8-activating enzyme E1 catalytic subunit OS=Homo sapiens OX=9606 GN=UBA3 PE=1 SV=2" "0.000" "False" "20.582" "15" "7" "11" "7" "463" "51.8" "5.45" "31.20" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00899, Pf08825" "9039" "ENSG00000144744" "UBA3" "A6NLB5; A8K027; hsa:9039; O76088; Q8TBC4; Q9NTU3" "Hijack of ubiquitination by SARS-CoV-2" "Antigen processing: Ubiquitination & Proteasome degradation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Neddylation" "5" "0" "0.940" "0.975" "0.953" "0.975" "0.958" "0.896" "0.899" "0.854" "0.935" "856.1" "805.1" "834.6" "815.5" "834.6" "819.9" "767.3" "769.5" "731.3" "800.4" "" "" "" "" "" "" "" "" "" "" "802.1" "666.2" "774.8" "630.5" "711.4" "783.3" "701.1" "683.3" "731.3" "770.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8637323044109722120" "False" "High" "IsMasterProtein" "Q2NKX8" "DNA excision repair protein ERCC-6-like OS=Homo sapiens OX=9606 GN=ERCC6L PE=1 SV=1" "0.000" "False" "20.575" "6" "7" "8" "7" "1250" "141.0" "5.31" "16.72" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "54821" "ENSG00000186871" "ERCC6L" "hsa:54821; Q2NKX8; Q8NCI1; Q96H93; Q9NXQ8" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.019" "0.958" "0.940" "1.023" "0.978" "0.985" "0.979" "0.976" "1.014" "995.4" "1014.5" "953.5" "935.9" "1017.9" "974.0" "980.8" "974.7" "971.0" "1009.4" "" "" "" "" "" "" "" "" "" "" "932.7" "839.5" "885.2" "723.5" "867.6" "930.5" "896.2" "865.5" "971.0" "971.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5940813161561783541" "False" "High" "IsMasterProtein" "Q9H078" "Mitochondrial disaggregase OS=Homo sapiens OX=9606 GN=CLPB PE=1 SV=1" "0.000" "False" "20.558" "10" "7" "10" "7" "707" "78.7" "9.01" "20.64" "7" "stress response;signal transduction;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf07724, Pf10431, Pf12796" "81570" "ENSG00000162129" "CLPB" "B4DXJ7; B4DXP7; B4DXW4; E7EWN6; F8W7P6; hsa:81570; Q8ND11; Q9H078; Q9H8Y0" "" "" "0" "0" "1.020" "1.060" "1.106" "1.087" "1.097" "1.069" "1.134" "1.064" "1.051" "1208.8" "1232.9" "1280.8" "1337.4" "1313.7" "1326.5" "1292.8" "1371.0" "1286.5" "1270.4" "" "" "" "" "" "" "" "" "" "" "1132.7" "1020.2" "1189.1" "1033.9" "1119.8" "1267.4" "1181.3" "1217.3" "1286.5" "1223.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6956886752181187117" "False" "High" "IsMasterProtein" "P55039" "Developmentally-regulated GTP-binding protein 2 OS=Homo sapiens OX=9606 GN=DRG2 PE=1 SV=1" "0.000" "False" "20.555" "18" "7" "14" "6" "364" "40.7" "8.88" "42.36" "7" "protein metabolism;other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01926, Pf02824, Pf16897" "1819" "ENSG00000108591" "DRG2" "B2R8G5; hsa:1819; P55039; Q53Y50; Q9BWB2" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Protein hydroxylation" "2" "0" "0.981" "1.026" "1.020" "1.018" "1.037" "0.997" "0.975" "0.966" "1.040" "823.1" "807.6" "844.7" "839.5" "838.1" "853.7" "820.7" "802.4" "795.2" "855.8" "" "" "" "" "" "" "" "" "" "" "771.3" "668.2" "784.2" "649.0" "714.3" "815.6" "749.9" "712.5" "795.2" "824.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2857218708684993243" "False" "High" "IsMasterProtein" "Q9Y315" "Deoxyribose-phosphate aldolase OS=Homo sapiens OX=9606 GN=DERA PE=1 SV=2" "0.000" "False" "20.543" "22" "7" "9" "7" "318" "35.2" "8.94" "28.44" "7" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01791" "51071" "ENSG00000023697" "DERA" "hsa:51071; Q53HN9; Q6PHW2; Q9Y315" "Pentose phosphate pathway in senescent cells" "Neutrophil degranulation; Pentose phosphate pathway" "3" "0" "1.077" "0.975" "1.100" "1.038" "1.065" "1.028" "0.966" "1.034" "1.001" "504.2" "543.1" "491.4" "554.6" "523.4" "537.0" "518.1" "487.1" "521.3" "504.5" "" "" "" "" "" "" "" "" "" "" "472.5" "449.4" "456.2" "428.7" "446.2" "513.0" "473.4" "432.5" "521.3" "485.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7224643183628006691" "False" "High" "IsMasterProtein" "O00303" "Eukaryotic translation initiation factor 3 subunit F OS=Homo sapiens OX=9606 GN=EIF3F PE=1 SV=1" "0.000" "False" "20.529" "18" "6" "10" "6" "357" "37.5" "5.45" "26.30" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf13012" "8665" "ENSG00000175390" "EIF3F" "A8K0S2; hsa:8665; O00303; Q6IB45; Q8N978" "Translation factors; VEGFA-VEGFR2 signaling; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "9" "0" "0.985" "1.067" "0.987" "0.970" "0.941" "1.082" "1.062" "1.082" "1.007" "1096.6" "1079.7" "1169.8" "1082.5" "1063.7" "1032.4" "1186.9" "1164.5" "1186.4" "1104.1" "" "" "" "" "" "" "" "" "" "" "1027.5" "893.4" "1086.0" "836.8" "906.7" "986.4" "1084.5" "1034.0" "1186.4" "1063.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1448578471139674410" "False" "High" "IsMasterProtein" "Q6PJ69" "E3 ubiquitin-protein ligase TRIM65 OS=Homo sapiens OX=9606 GN=TRIM65 PE=1 SV=3" "0.000" "False" "20.523" "14" "7" "11" "7" "517" "57.3" "6.70" "34.18" "7" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097, Pf00622, Pf00643" "201292" "ENSG00000141569" "TRIM65" "hsa:201292; Q4G0F0; Q6DKJ6; Q6PJ69; Q9BRP6" "" "" "0" "0" "0.972" "0.942" "0.984" "0.979" "0.961" "0.960" "0.928" "0.907" "0.985" "500.1" "486.3" "471.2" "492.1" "489.4" "480.7" "480.3" "463.9" "453.4" "492.5" "" "" "" "" "" "" "" "" "" "" "468.6" "402.4" "437.4" "380.5" "417.2" "459.3" "438.9" "411.9" "453.4" "474.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088552440920446999" "False" "High" "IsMasterProtein" "Q9Y570" "Protein phosphatase methylesterase 1 OS=Homo sapiens OX=9606 GN=PPME1 PE=1 SV=3" "0.000" "False" "20.511" "22" "7" "10" "7" "386" "42.3" "5.97" "30.38" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf12697" "51400" "ENSG00000214517" "PPME1" "B3KMU6; B5MEE7; hsa:51400; J3QT22; Q8WYG8; Q9NVT5; Q9UI18; Q9Y570" "" "Cyclin A/B1/B2 associated events during G2/M transition" "1" "0" "0.974" "0.992" "0.992" "0.983" "0.949" "0.980" "0.970" "0.896" "0.943" "721.3" "702.9" "715.7" "715.5" "709.3" "684.9" "707.1" "699.4" "646.1" "679.9" "" "" "" "" "" "" "" "" "" "" "675.9" "581.6" "664.5" "553.1" "604.6" "654.3" "646.1" "621.0" "646.1" "654.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6322413842474440718" "False" "High" "IsMasterProtein" "Q96IR7" "4-hydroxyphenylpyruvate dioxygenase-like protein OS=Homo sapiens OX=9606 GN=HPDL PE=1 SV=1" "0.000" "False" "20.503" "18" "5" "9" "5" "371" "39.4" "7.03" "27.94" "5" "other metabolic processes" "mitochondrion" "other molecular function" "" "84842" "ENSG00000186603" "HPDL" "B2R9B0; hsa:84842; Q96IR7" "" "" "0" "0" "1.162" "1.176" "1.199" "1.137" "1.137" "1.123" "1.096" "1.169" "1.065" "161.7" "187.9" "190.2" "193.9" "183.8" "183.9" "181.6" "177.3" "189.1" "172.2" "" "" "" "" "" "" "" "" "" "" "151.5" "155.5" "176.6" "149.9" "156.7" "175.7" "165.9" "157.4" "189.1" "165.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7053379414769105992" "False" "High" "IsMasterProtein" "Q92905" "COP9 signalosome complex subunit 5 OS=Homo sapiens OX=9606 GN=COPS5 PE=1 SV=4" "0.000" "False" "20.488" "24" "6" "9" "6" "334" "37.6" "6.54" "31.79" "6" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf18323" "10987" "ENSG00000121022" "COPS5" "hsa:10987; O15386; Q6AW95; Q86WQ4; Q92905; Q9BQ17" "TGF-beta signaling pathway" "Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER" "5" "0" "0.947" "0.964" "0.993" "0.942" "0.955" "0.957" "0.982" "0.956" "0.930" "1136.6" "1076.5" "1095.4" "1128.6" "1070.7" "1085.6" "1088.2" "1115.9" "1086.6" "1057.4" "" "" "" "" "" "" "" "" "" "" "1065.0" "890.8" "1017.0" "872.5" "912.6" "1037.2" "994.4" "990.8" "1086.6" "1018.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8090563644210438212" "False" "High" "IsMasterProtein" "Q6V1X1" "Dipeptidyl peptidase 8 OS=Homo sapiens OX=9606 GN=DPP8 PE=1 SV=1" "0.000" "False" "20.486" "8" "8" "9" "7" "898" "103.3" "5.80" "24.75" "8" "protein metabolism;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00326, Pf00930, Pf19520" "54878" "ENSG00000074603" "DPP8" "hsa:54878; Q6V1X1; Q7Z4C8; Q7Z4D3; Q7Z4E1; Q8IWG7; Q8NEM5; Q96JX1; Q9HBM2; Q9HBM3; Q9HBM4; Q9HBM5; Q9NXF4" "" "" "0" "0" "0.942" "1.037" "1.026" "1.026" "1.039" "0.966" "0.965" "0.999" "1.004" "626.3" "589.7" "649.7" "642.5" "642.4" "650.9" "605.0" "604.3" "625.5" "628.8" "" "" "" "" "" "" "" "" "" "" "586.8" "487.9" "603.2" "496.7" "547.6" "621.9" "552.8" "536.6" "625.5" "605.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6634155616669097337" "False" "High" "IsMasterProtein" "P42768" "Actin nucleation-promoting factor WAS OS=Homo sapiens OX=9606 GN=WAS PE=1 SV=4" "0.000" "False" "20.473" "15" "7" "15" "7" "502" "52.9" "6.64" "47.70" "7" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00568, Pf00786, Pf02205" "7454" "ENSG00000015285" "WAS" "hsa:7454; P42768; Q9BU11; Q9UNJ9" "Pathogenic Escherichia coli infection; Complement system; Chemokine signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; T-cell receptor signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Generation of second messenger molecules; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOJ GTPase cycle" "13" "0" "0.991" "1.004" "0.980" "0.981" "0.976" "0.977" "0.989" "0.943" "0.963" "1386.7" "1373.8" "1391.7" "1358.3" "1360.3" "1353.8" "1355.3" "1372.1" "1307.3" "1336.0" "" "" "" "" "" "" "" "" "" "" "1299.4" "1136.8" "1292.0" "1050.0" "1159.5" "1293.5" "1238.4" "1218.3" "1307.3" "1286.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3978258356038081382" "False" "High" "IsMasterProtein" "Q13416" "Origin recognition complex subunit 2 OS=Homo sapiens OX=9606 GN=ORC2 PE=1 SV=2" "0.000" "False" "20.462" "14" "9" "11" "9" "577" "65.9" "6.51" "29.56" "9" "DNA metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf04084" "4999" "ENSG00000115942" "ORC2" "hsa:4999; Q13204; Q13416; Q53TX5" "Cell cycle; G1 to S cell cycle control; DNA replication" "Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Orc1 removal from chromatin; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication; CDC6 association with the ORC:origin complex" "10" "0" "1.042" "1.070" "1.025" "1.048" "1.040" "0.956" "1.003" "1.035" "1.047" "1789.6" "1864.0" "1915.3" "1834.3" "1875.1" "1861.8" "1710.4" "1794.5" "1852.7" "1874.6" "" "" "" "" "" "" "" "" "" "" "1676.9" "1542.5" "1778.2" "1418.0" "1598.3" "1778.8" "1562.8" "1593.3" "1852.7" "1805.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6445951316860718443" "False" "High" "IsMasterProtein" "O60343" "TBC1 domain family member 4 OS=Homo sapiens OX=9606 GN=TBC1D4 PE=1 SV=2" "0.000" "False" "20.459" "6" "7" "8" "7" "1298" "146.5" "7.01" "21.42" "7" "transport;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00566, Pf00640, Pf11830" "9882" "ENSG00000136111" "TBC1D4" "A7E2X8; B4DU25; B4E235; B6ETN8; B6ETN9; hsa:9882; O60343; Q5W0B9; Q68D14" "Ciliary landscape; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "4" "0" "1.003" "1.032" "1.112" "1.099" "1.017" "0.999" "1.064" "1.085" "1.085" "591.3" "592.9" "610.0" "657.4" "650.1" "601.2" "591.0" "629.2" "641.4" "641.8" "" "" "" "" "" "" "" "" "" "" "554.1" "490.6" "566.3" "508.2" "554.1" "574.4" "540.0" "558.7" "641.4" "618.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2226975815601185074" "False" "High" "IsMasterProtein" "Q15742" "NGFI-A-binding protein 2 OS=Homo sapiens OX=9606 GN=NAB2 PE=1 SV=1" "0.000" "False" "20.456" "14" "8" "10" "7" "525" "56.6" "6.96" "27.59" "8" "developmental processes;other biological processes" "nucleus" "other molecular function" "Pf04904, Pf04905" "4665" "ENSG00000166886" "NAB2" "B2RAK3; hsa:4665; O76006; Q14797; Q15742" "" "NGF-stimulated transcription; EGR2 and SOX10-mediated initiation of Schwann cell myelination" "2" "0" "0.996" "0.979" "1.063" "1.040" "1.012" "0.959" "0.954" "0.960" "1.030" "740.4" "737.8" "724.7" "787.0" "769.7" "749.1" "710.4" "706.4" "711.0" "762.5" "" "" "" "" "" "" "" "" "" "" "693.8" "610.5" "672.8" "608.4" "656.1" "715.7" "649.1" "627.2" "711.0" "734.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8724268624419382152" "False" "High" "IsMasterProtein" "P50213" "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3A PE=1 SV=1" "0.000" "False" "20.440" "20" "8" "11" "8" "366" "39.6" "6.92" "31.06" "8" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00180" "3419" "ENSG00000166411" "IDH3A" "D3DW83; hsa:3419; P50213; Q9H3X0" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Metabolic reprogramming in colon cancer; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "5" "0" "1.003" "0.972" "0.912" "0.964" "0.992" "0.988" "0.893" "0.987" "0.954" "1888.0" "1892.8" "1835.0" "1721.9" "1819.3" "1872.0" "1866.1" "1685.6" "1864.2" "1801.5" "" "" "" "" "" "" "" "" "" "" "1769.1" "1566.3" "1703.5" "1331.1" "1550.7" "1788.5" "1705.1" "1496.6" "1864.2" "1734.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1583650821826420104" "False" "High" "IsMasterProtein" "Q9H9A5" "CCR4-NOT transcription complex subunit 10 OS=Homo sapiens OX=9606 GN=CNOT10 PE=1 SV=1" "0.000" "False" "20.437" "9" "7" "8" "7" "744" "82.3" "7.78" "26.06" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "" "25904" "ENSG00000182973; ENSG00000291502" "CNOT10" "B7Z7L1; F8WAF2; hsa:25904; Q9BU30; Q9H5J7; Q9H8X1; Q9H9A5; Q9H9W0; Q9HAH3; Q9UFJ2" "Ciliary landscape" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" "4" "0" "0.973" "0.990" "0.982" "1.020" "1.000" "1.012" "1.019" "1.047" "1.013" "906.1" "882.1" "896.7" "889.7" "924.2" "906.2" "917.0" "923.3" "948.6" "917.6" "" "" "" "" "" "" "" "" "" "" "849.0" "729.9" "832.5" "687.7" "787.8" "865.8" "837.9" "819.8" "948.6" "883.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7131720843867798084" "False" "High" "IsMasterProtein" "Q9BT09" "Protein canopy homolog 3 OS=Homo sapiens OX=9606 GN=CNPY3 PE=1 SV=1" "0.000" "False" "20.435" "21" "6" "7" "6" "278" "30.7" "5.49" "24.87" "6" "stress response" "ER/Golgi" "signal transduction activity or receptor binding" "Pf11938" "10695" "ENSG00000137161" "CNPY3" "hsa:10695; O15412; Q0P6I2; Q8NF54; Q8WTU8; Q9BT09; Q9P0F2" "" "Trafficking and processing of endosomal TLR" "1" "0" "1.082" "0.969" "0.899" "1.000" "1.044" "0.898" "0.994" "0.978" "0.995" "1105.9" "1196.8" "1071.8" "994.6" "1105.7" "1154.7" "993.0" "1099.5" "1081.9" "1099.9" "" "" "" "" "" "" "" "" "" "" "1036.3" "990.4" "995.1" "768.9" "942.5" "1103.2" "907.3" "976.2" "1081.9" "1059.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6657686065862137180" "False" "High" "IsMasterProtein" "Q9Y371" "Endophilin-B1 OS=Homo sapiens OX=9606 GN=SH3GLB1 PE=1 SV=1" "0.000" "False" "20.429" "17" "7" "9" "6" "365" "40.8" "6.04" "30.69" "7" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03114, Pf14604" "51100" "ENSG00000097033" "SH3GLB1" "B4E182; hsa:51100; Q5H8U5; Q9H3Z0; Q9NR47; Q9NYA9; Q9Y371" "Nanoparticle triggered autophagic cell death" "" "1" "0" "1.027" "0.957" "0.950" "1.012" "0.968" "0.967" "0.933" "0.937" "1.000" "1656.0" "1700.7" "1584.2" "1573.5" "1675.1" "1602.7" "1601.1" "1544.7" "1551.2" "1655.5" "" "" "" "" "" "" "" "" "" "" "1551.7" "1407.3" "1470.7" "1216.4" "1427.8" "1531.2" "1463.0" "1371.5" "1551.2" "1594.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8898508644132712333" "False" "High" "IsMasterProtein" "Q01130" "Serine/arginine-rich splicing factor 2 OS=Homo sapiens OX=9606 GN=SRSF2 PE=1 SV=4" "0.000" "False" "20.418" "24" "6" "10" "6" "221" "25.5" "11.85" "28.94" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "6427" "ENSG00000161547" "SRSF2" "B3KWD5; B4DN89; H0YG49; hsa:6427; Q01130" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway" "7" "0" "1.059" "1.273" "1.053" "1.094" "1.122" "1.103" "1.063" "1.062" "1.061" "628.9" "666.0" "800.9" "662.5" "688.0" "705.6" "693.9" "668.8" "668.0" "667.2" "" "" "" "" "" "" "" "" "" "" "589.3" "551.1" "743.6" "512.1" "586.4" "674.1" "634.1" "593.8" "668.0" "642.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4682343242687865588" "False" "High" "IsMasterProtein" "O43818" "U3 small nucleolar RNA-interacting protein 2 OS=Homo sapiens OX=9606 GN=RRP9 PE=1 SV=1" "0.000" "False" "20.411" "14" "7" "11" "7" "475" "51.8" "7.85" "33.78" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00400" "9136" "ENSG00000114767" "RRP9" "B2R996; hsa:9136; O43818; Q8IZ30" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.126" "1.058" "1.142" "1.085" "1.125" "1.254" "1.220" "1.193" "1.086" "1730.7" "1949.0" "1831.7" "1977.1" "1878.4" "1947.9" "2169.6" "2112.2" "2064.0" "1878.8" "" "" "" "" "" "" "" "" "" "" "1621.7" "1612.8" "1700.5" "1528.4" "1601.1" "1861.0" "1982.4" "1875.4" "2064.0" "1809.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8026992804565503724" "False" "High" "IsMasterProtein" "Q13257" "Mitotic spindle assembly checkpoint protein MAD2A OS=Homo sapiens OX=9606 GN=MAD2L1 PE=1 SV=1" "0.000" "False" "20.410" "33" "7" "9" "7" "205" "23.5" "5.08" "30.78" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf02301" "4085" "ENSG00000164109" "MAD2L1" "hsa:4085; Q13257; Q53F56; Q548X9; Q6IRW7; Q8IZX3" "Regulation of sister chromatid separation at the metaphase-anaphase transition; Pleural mesothelioma" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "13" "0" "0.955" "1.005" "0.965" "0.976" "1.020" "0.920" "0.926" "0.931" "0.982" "2062.4" "1968.6" "2072.7" "1990.2" "2011.9" "2102.8" "1897.6" "1909.6" "1920.2" "2026.0" "" "" "" "" "" "" "" "" "" "" "1932.5" "1629.0" "1924.3" "1538.5" "1714.9" "2009.0" "1733.9" "1695.5" "1920.2" "1950.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5097285546309815512" "False" "High" "IsMasterProtein" "Q8NEB9" "Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Homo sapiens OX=9606 GN=PIK3C3 PE=1 SV=1" "0.000" "False" "20.408" "11" "9" "9" "9" "887" "101.5" "6.81" "19.42" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792" "5289" "ENSG00000078142" "PIK3C3" "hsa:5289; Q15134; Q8NEB9" "AMP-activated protein kinase signaling; Alzheimer's disease and miRNA effects; Angiopoietin-like protein 8 regulatory pathway; Microglia pathogen phagocytosis pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Osteoblast differentiation and related diseases; Insulin signaling; Autophagy; Regulation of actin cytoskeleton; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP; DNA damage response (only ATM dependent)" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; PI3K Cascade; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; RHO GTPases Activate NADPH Oxidases; Toll Like Receptor 9 (TLR9) Cascade" "24" "0" "1.050" "1.039" "1.053" "1.050" "1.059" "0.964" "1.014" "1.029" "1.034" "813.1" "853.8" "845.1" "856.3" "854.1" "861.2" "783.7" "824.2" "836.9" "840.4" "" "" "" "" "" "" "" "" "" "" "761.8" "706.5" "784.5" "662.0" "728.0" "822.8" "716.1" "731.8" "836.9" "809.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-323839447441261697" "False" "High" "IsMasterProtein" "Q9NWK9" "Box C/D snoRNA protein 1 OS=Homo sapiens OX=9606 GN=ZNHIT6 PE=1 SV=1" "0.000" "False" "20.361" "19" "7" "8" "7" "470" "53.9" "5.80" "29.00" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04438" "54680" "ENSG00000117174" "ZNHIT6" "B2RBA1; B4DP13; D3DT20; hsa:54680; Q9H278; Q9H3X3; Q9NWK9; Q9NWN0" "" "" "0" "0" "0.957" "0.967" "0.946" "0.992" "0.986" "0.838" "0.840" "0.853" "0.970" "1554.5" "1487.7" "1503.9" "1470.3" "1542.4" "1532.9" "1303.1" "1305.1" "1325.6" "1507.3" "" "" "" "" "" "" "" "" "" "" "1456.6" "1231.1" "1396.2" "1136.6" "1314.7" "1464.5" "1190.7" "1158.8" "1325.6" "1451.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4877506006391296740" "False" "High" "IsMasterProtein" "P28072" "Proteasome subunit beta type-6 OS=Homo sapiens OX=9606 GN=PSMB6 PE=1 SV=4" "0.000" "False" "20.333" "23" "6" "16" "6" "239" "25.3" "4.92" "48.20" "6" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00227" "5694" "ENSG00000142507" "PSMB6" "hsa:5694; P28072; Q96J55" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.975" "0.965" "0.975" "0.941" "0.983" "0.924" "0.935" "0.987" "0.947" "1760.3" "1715.7" "1698.0" "1715.5" "1656.2" "1730.1" "1626.3" "1646.7" "1737.7" "1666.9" "" "" "" "" "" "" "" "" "" "" "1649.4" "1419.7" "1576.4" "1326.2" "1411.7" "1652.9" "1486.0" "1462.1" "1737.7" "1605.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9008482199911470815" "False" "High" "IsMasterProtein" "O43516" "WAS/WASL-interacting protein family member 1 OS=Homo sapiens OX=9606 GN=WIPF1 PE=1 SV=3" "0.000" "False" "20.328" "16" "7" "8" "7" "503" "51.2" "11.47" "30.27" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "7456" "ENSG00000115935" "WIPF1" "B8ZZM1; D3DPE4; hsa:7456; O43516; Q15220; Q53TA9; Q6MZU9; Q9BU37; Q9UNP1" "" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs" "5" "0" "1.057" "0.940" "1.071" "1.003" "0.950" "1.014" "0.967" "0.940" "0.961" "1285.4" "1358.2" "1207.9" "1376.1" "1289.9" "1221.6" "1303.0" "1243.3" "1207.9" "1234.8" "" "" "" "" "" "" "" "" "" "" "1204.4" "1123.9" "1121.4" "1063.8" "1099.4" "1167.2" "1190.6" "1103.9" "1207.9" "1189.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4115267819831113520" "False" "High" "IsMasterProtein" "Q8IX18" "Probable ATP-dependent RNA helicase DHX40 OS=Homo sapiens OX=9606 GN=DHX40 PE=1 SV=2" "0.000" "False" "20.327" "9" "9" "10" "9" "779" "88.5" "8.65" "26.19" "9" "" "" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "79665" "ENSG00000108406" "DHX40" "B3KTJ5; C9JR60; hsa:79665; Q5JPH4; Q8IX18; Q8TC86; Q8WY53; Q9BXM1; Q9H6M9" "" "" "0" "0" "1.054" "1.039" "1.041" "1.051" "1.018" "1.011" "1.001" "1.063" "1.058" "721.7" "760.6" "749.6" "751.5" "758.7" "734.5" "730.0" "722.3" "767.2" "764.0" "" "" "" "" "" "" "" "" "" "" "676.3" "629.4" "695.9" "581.0" "646.7" "701.8" "667.0" "641.4" "767.2" "735.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8890451219668255439" "False" "High" "IsMasterProtein" "Q9NZC9" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 OS=Homo sapiens OX=9606 GN=SMARCAL1 PE=1 SV=1" "0.000" "False" "20.315" "9" "8" "8" "8" "954" "105.9" "9.06" "21.73" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf07443" "50485" "ENSG00000138375" "SMARCAL1" "A6NEH0; hsa:50485; Q53R00; Q96AY1; Q9NXQ5; Q9NZC9; Q9UFH3; Q9UI93" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome" "" "2" "0" "1.033" "1.042" "1.017" "1.044" "1.192" "1.009" "1.000" "1.082" "1.111" "562.6" "581.4" "586.4" "572.3" "587.1" "670.3" "567.4" "562.7" "608.6" "625.3" "" "" "" "" "" "" "" "" "" "" "527.1" "481.1" "544.4" "442.4" "500.5" "640.4" "518.4" "499.6" "608.6" "602.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7866800410965669169" "False" "High" "IsMasterProtein" "Q9H0G5" "Nuclear speckle splicing regulatory protein 1 OS=Homo sapiens OX=9606 GN=NSRP1 PE=1 SV=1" "0.000" "False" "20.309" "13" "7" "9" "7" "558" "66.4" "8.84" "26.72" "7" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09745, Pf20427" "84081" "ENSG00000126653" "NSRP1" "hsa:84081; Q6FI71; Q9H0G5" "" "mRNA Splicing - Major Pathway" "1" "0" "0.991" "1.070" "1.024" "1.040" "1.048" "1.119" "1.101" "1.124" "1.063" "1282.9" "1271.5" "1372.4" "1313.7" "1334.1" "1344.5" "1435.3" "1412.5" "1442.3" "1364.0" "" "" "" "" "" "" "" "" "" "" "1202.1" "1052.2" "1274.1" "1015.6" "1137.1" "1284.6" "1311.4" "1254.2" "1442.3" "1313.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5153140893326454359" "False" "High" "IsMasterProtein" "Q99496" "E3 ubiquitin-protein ligase RING2 OS=Homo sapiens OX=9606 GN=RNF2 PE=1 SV=1" "0.000" "False" "20.272" "22" "7" "11" "7" "336" "37.6" "6.84" "33.95" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13923, Pf16207" "6045" "ENSG00000121481" "RNF2" "B2RBS7; B3KRH1; Q5TEN1; Q5TEN2; Q99496" "FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma" "Transcriptional Regulation by E2F6; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "11" "0" "1.040" "1.051" "1.175" "1.126" "1.056" "1.199" "1.239" "1.162" "1.129" "634.8" "660.0" "667.4" "745.8" "714.5" "670.3" "761.2" "786.3" "737.7" "716.5" "" "" "" "" "" "" "" "" "" "" "594.8" "546.1" "619.6" "576.6" "609.0" "640.4" "695.5" "698.1" "737.7" "689.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5390020710088679993" "False" "High" "IsMasterProtein" "O75368" "Adapter SH3BGRL OS=Homo sapiens OX=9606 GN=SH3BGRL PE=1 SV=1" "0.000" "False" "20.256" "61" "6" "8" "6" "114" "12.8" "5.25" "24.04" "6" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04908" "6451" "ENSG00000131171" "SH3BGRL" "hsa:6451; O75368; Q3SYL1; Q5JT50; Q6FIE8; Q9H0N8" "" "" "0" "0" "0.994" "0.979" "0.856" "0.894" "0.909" "0.884" "0.888" "0.924" "0.909" "1446.4" "1437.3" "1416.7" "1238.8" "1293.2" "1314.2" "1278.2" "1284.8" "1336.8" "1315.4" "" "" "" "" "" "" "" "" "" "" "1355.3" "1189.3" "1315.2" "957.6" "1102.3" "1255.6" "1168.0" "1140.8" "1336.8" "1266.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7088025864314276117" "False" "High" "IsMasterProtein" "O95793" "Double-stranded RNA-binding protein Staufen homolog 1 OS=Homo sapiens OX=9606 GN=STAU1 PE=1 SV=2" "0.000" "False" "20.234" "10" "6" "6" "5" "577" "63.1" "9.44" "21.36" "6" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf16482" "6780" "ENSG00000124214" "STAU1" "A8K9Z4; E1P5Y1; E1P608; hsa:6780; O95793; Q5JW29; Q6GTM4; Q9H5B4; Q9H5B5; Q9Y3Q2" "" "" "0" "0" "0.989" "1.016" "1.018" "1.101" "1.098" "1.039" "1.076" "1.007" "1.010" "755.3" "747.2" "767.1" "769.1" "831.4" "829.4" "784.6" "812.6" "760.2" "763.1" "" "" "" "" "" "" "" "" "" "" "707.7" "618.3" "712.2" "594.6" "708.7" "792.4" "717.0" "721.5" "760.2" "734.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1603503262744250251" "False" "High" "IsMasterProtein" "P62805" "Histone H4 OS=Homo sapiens OX=9606 GN=H4C16 PE=1 SV=2" "0.000" "False" "20.216" "50" "5" "15" "5" "103" "11.4" "11.36" "46.49" "5" "cell organization and biogenesis;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15511" "121504; 554313; 8294; 8359; 8360; 8361; 8362; 8363; 8364; 8365; 8366; 8367; 8368; 8370" "ENSG00000158406; ENSG00000197061; ENSG00000197238; ENSG00000197837; ENSG00000270276; ENSG00000270882; ENSG00000273542; ENSG00000274618; ENSG00000275126; ENSG00000276180; ENSG00000276966; ENSG00000277157; ENSG00000278637; ENSG00000278705" "H4C1; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9" "A2VCL0; hsa:121504; hsa:554313; hsa:8294; hsa:8359; hsa:8360; hsa:8361; hsa:8362; hsa:8363; hsa:8364; hsa:8365; hsa:8366; hsa:8367; hsa:8368; hsa:8370; P02304; P02305; P62805; Q6DRA9; Q6FGB8; Q6NWP7" "Gastric cancer network 1; Histone modifications; 22q11.2 copy number variation syndrome; Male infertility; Type II interferon signaling" "Oxidative Stress Induced Senescence; Pre-NOTCH Transcription and Translation; HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Senescence-Associated Secretory Phenotype (SASP); RNA Polymerase I Promoter Opening; SUMOylation of chromatin organization proteins; Processing of DNA double-strand break ends; HCMV Late Events; Amyloid fiber formation; Meiotic synapsis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Early Events; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Formation of the beta-catenin:TCF transactivating complex; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RMTs methylate histone arginines; HDMs demethylate histones; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; G2/M DNA damage checkpoint; HATs acetylate histones; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; DNA methylation; Nonhomologous End-Joining (NHEJ); Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "52" "0" "1.070" "1.037" "1.099" "1.110" "1.080" "1.086" "1.050" "1.138" "1.079" "1068.6" "1143.6" "1107.8" "1174.3" "1185.8" "1154.1" "1160.9" "1122.2" "1216.1" "1152.7" "" "" "" "" "" "" "" "" "" "" "1001.3" "946.3" "1028.4" "907.8" "1010.8" "1102.6" "1060.7" "996.4" "1216.1" "1109.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2591250137459754120" "False" "High" "IsMasterProtein" "O43252" "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 OS=Homo sapiens OX=9606 GN=PAPSS1 PE=1 SV=2" "0.000" "False" "20.209" "12" "7" "9" "7" "624" "70.8" "6.86" "27.81" "7" "other metabolic processes;developmental processes" "cytosol" "kinase activity;other molecular function" "Pf01583, Pf01747, Pf14306" "9061" "ENSG00000138801" "PAPSS1" "hsa:9061; O43252; O43841; O75332; Q6IAX6; Q96FB1; Q96TF4; Q9P1P9; Q9UE98" "Sulfation biotransformation reaction" "Signaling by BRAF and RAF1 fusions; Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se" "4" "0" "0.930" "0.981" "1.020" "0.951" "0.914" "0.956" "1.037" "0.948" "0.940" "794.9" "739.2" "780.2" "810.7" "755.9" "726.6" "759.9" "824.7" "753.5" "747.4" "" "" "" "" "" "" "" "" "" "" "744.8" "611.7" "724.3" "626.7" "644.3" "694.2" "694.3" "732.3" "753.5" "719.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6641856841102683489" "False" "High" "IsMasterProtein" "P62826" "GTP-binding nuclear protein Ran OS=Homo sapiens OX=9606 GN=RAN PE=1 SV=3" "0.000" "False" "20.197" "26" "6" "17" "6" "216" "24.4" "7.49" "46.56" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5901" "ENSG00000132341" "RAN" "A8K3Z8; hsa:5901; P17080; P28746; P28747; P62826; Q6IPB2; Q86V08; Q8NI90; Q9CSP3; Q9CWI7; Q9CZA2; Q9UDJ5; Q9UEU9" "Androgen receptor signaling pathway; miRNA biogenesis; 22q11.2 copy number variation syndrome" "Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Nuclear import of Rev protein; Transcriptional regulation by small RNAs; tRNA processing in the nucleus; Regulation of cholesterol biosynthesis by SREBP (SREBF); MicroRNA (miRNA) biogenesis; Postmitotic nuclear pore complex (NPC) reformation" "11" "0" "1.063" "0.878" "1.037" "0.827" "0.931" "0.882" "0.871" "1.030" "0.931" "1063.2" "1130.3" "933.9" "1102.7" "878.9" "990.3" "937.2" "926.2" "1094.6" "989.7" "" "" "" "" "" "" "" "" "" "" "996.2" "935.3" "867.0" "852.4" "749.1" "946.1" "856.4" "822.4" "1094.6" "953.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5370481134034691073" "False" "High" "IsMasterProtein" "P22307" "Sterol carrier protein 2 OS=Homo sapiens OX=9606 GN=SCP2 PE=1 SV=2" "0.000" "False" "20.186" "11" "7" "7" "7" "547" "59.0" "6.89" "22.95" "7" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00108, Pf02036, Pf02803" "6342" "ENSG00000116171" "SCP2" "A6NM69; B4DGJ9; B4DHP6; C9JC79; D3DQ37; E1B6W5; F2Z3J1; hsa:6342; P22307; Q15432; Q16622; Q5VVZ1; Q6NXF4; Q99430" "PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Mitochondrial fatty acid oxidation disorders; DNA damage response (only ATM dependent)" "TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism" "10" "0" "1.025" "0.921" "0.935" "0.992" "1.134" "0.916" "1.000" "0.903" "0.947" "542.1" "555.9" "499.1" "506.8" "537.7" "614.7" "496.6" "542.2" "489.6" "513.5" "" "" "" "" "" "" "" "" "" "" "507.9" "460.0" "463.4" "391.8" "458.3" "587.3" "453.8" "481.4" "489.6" "494.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "291264612704325176" "False" "High" "IsMasterProtein" "Q13685" "Angio-associated migratory cell protein OS=Homo sapiens OX=9606 GN=AAMP PE=1 SV=2" "0.000" "False" "20.161" "15" "6" "9" "6" "434" "46.7" "4.42" "32.60" "6" "developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00400" "14" "ENSG00000127837" "AAMP" "hsa:14; Q13685; Q8WUJ9; Q96H92" "Nucleotide-binding oligomerization domain (NOD) pathway" "Thromboxane signalling through TP receptor; Signaling by EGFR; NOD1/2 Signaling Pathway; Signaling by VEGF" "5" "0" "1.038" "1.128" "1.196" "1.159" "1.111" "1.152" "1.170" "1.165" "1.212" "536.9" "557.3" "605.4" "642.2" "622.0" "596.4" "618.4" "628.4" "625.3" "650.7" "" "" "" "" "" "" "" "" "" "" "503.0" "461.2" "562.1" "496.4" "530.2" "569.8" "565.1" "558.0" "625.3" "626.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4274209066083096437" "False" "High" "IsMasterProtein" "P46934" "E3 ubiquitin-protein ligase NEDD4 OS=Homo sapiens OX=9606 GN=NEDD4 PE=1 SV=4" "0.000" "False" "20.100" "6" "7" "10" "5" "1319" "149.0" "6.58" "23.21" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00397, Pf00632" "4734" "ENSG00000069869" "NEDD4" "A1KY35; A6ND72; A7MD29; B4E2R7; B7ZM59; B7ZM60; B9EGN5; D6RF89; hsa:4734; P46934" "Proteasome degradation; Ebola virus infection in host; EGF/EGFR signaling pathway; LDLRAD4 and what we know about it" "ISG15 antiviral mechanism; Antigen processing: Ubiquitination & Proteasome degradation; Regulation of PTEN stability and activity; Downregulation of ERBB4 signaling; Regulation of PTEN localization" "9" "1" "0.983" "0.976" "1.042" "1.082" "1.048" "0.992" "1.068" "0.965" "0.947" "308.2" "303.0" "300.9" "321.3" "333.4" "323.2" "305.8" "329.2" "297.3" "291.9" "" "" "" "" "" "" "" "" "" "" "288.8" "250.8" "279.4" "248.4" "284.2" "308.7" "279.4" "292.3" "297.3" "281.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1274747088330592999" "False" "High" "IsMasterProtein" "O94973" "AP-2 complex subunit alpha-2 OS=Homo sapiens OX=9606 GN=AP2A2 PE=1 SV=2" "0.000" "False" "20.093" "7" "8" "12" "1" "939" "103.9" "6.96" "38.94" "8" "transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02296, Pf02883" "161" "ENSG00000183020" "AP2A2" "hsa:161; O75403; O94973; Q53ET1; Q96SI8" "Synaptic vesicle pathway; GABA receptor signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Cell lineage map for neuronal differentiation" "Potential therapeutics for SARS; Recycling pathway of L1; MHC class II antigen presentation; Neutrophil degranulation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "18" "0" "1.160" "1.222" "1.320" "1.340" "1.140" "1.284" "1.198" "1.037" "1.362" "40.1" "46.6" "49.1" "53.0" "53.8" "45.8" "51.5" "48.1" "41.6" "54.7" "" "" "" "" "" "" "" "" "" "" "37.6" "38.6" "45.6" "41.0" "45.8" "43.7" "47.1" "42.7" "41.6" "52.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9119616111706856744" "False" "High" "IsMasterProtein" "Q9ULZ3" "Apoptosis-associated speck-like protein containing a CARD OS=Homo sapiens OX=9606 GN=PYCARD PE=1 SV=2" "0.000" "False" "20.072" "27" "5" "7" "5" "195" "21.6" "6.34" "24.07" "5" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00619, Pf02758" "29108" "ENSG00000103490" "PYCARD" "hsa:29108; Q96D12; Q9BSZ5; Q9HBD0; Q9NXJ8; Q9ULZ3" "Nucleotide-binding oligomerization domain (NOD) pathway; Nanomaterial-induced inflammasome activation; TYROBP causal network in microglia; Acute viral myocarditis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Prostaglandin signaling" "Neutrophil degranulation; The AIM2 inflammasome; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; CLEC7A/inflammasome pathway" "13" "0" "1.024" "1.072" "0.978" "1.027" "1.102" "1.045" "1.033" "1.062" "1.070" "748.7" "767.0" "802.8" "732.1" "768.8" "825.1" "782.4" "773.4" "795.2" "801.1" "" "" "" "" "" "" "" "" "" "" "701.6" "634.7" "745.3" "565.9" "655.3" "788.3" "714.9" "686.7" "795.2" "771.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1190496341580409730" "False" "High" "IsMasterProtein" "Q5TAX3" "Terminal uridylyltransferase 4 OS=Homo sapiens OX=9606 GN=TUT4 PE=1 SV=3" "0.000" "False" "20.070" "4" "8" "8" "7" "1644" "185.0" "7.97" "22.86" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098, Pf01909, Pf03828, Pf19088" "23318" "ENSG00000134744" "TUT4" "A2RRP0; B7Z8J5; D3DQ35; hsa:23318; Q12764; Q5TAX2; Q5TAX3; Q5TAX4; Q86XZ3" "" "Zygotic genome activation (ZGA); Deadenylation of mRNA; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "3" "0" "0.994" "0.979" "1.032" "1.037" "1.000" "0.979" "1.005" "0.964" "0.982" "547.6" "544.3" "536.3" "565.2" "568.1" "547.8" "536.2" "550.3" "527.9" "537.6" "" "" "" "" "" "" "" "" "" "" "513.1" "450.4" "497.9" "436.9" "484.2" "523.4" "490.0" "488.7" "527.9" "517.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5490413544944086937" "False" "High" "IsMasterProtein" "Q9BPX5" "Actin-related protein 2/3 complex subunit 5-like protein OS=Homo sapiens OX=9606 GN=ARPC5L PE=1 SV=1" "0.000" "False" "20.062" "46" "6" "8" "6" "153" "16.9" "6.60" "31.75" "6" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf04699" "81873" "ENSG00000136950" "ARPC5L" "hsa:81873; Q7Z523; Q9BPX5" "Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling" "" "2" "0" "1.020" "1.012" "1.015" "0.948" "0.966" "0.969" "0.908" "0.888" "0.971" "1348.5" "1375.9" "1364.9" "1369.1" "1278.1" "1302.1" "1307.3" "1224.1" "1197.6" "1309.7" "" "" "" "" "" "" "" "" "" "" "1263.5" "1138.5" "1267.1" "1058.4" "1089.4" "1244.0" "1194.6" "1086.8" "1197.6" "1261.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3800161177308876944" "False" "High" "IsMasterProtein" "Q8NEM2" "SHC SH2 domain-binding protein 1 OS=Homo sapiens OX=9606 GN=SHCBP1 PE=1 SV=3" "0.000" "False" "20.047" "10" "6" "7" "6" "672" "75.6" "4.75" "22.53" "6" "signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf13229" "79801" "ENSG00000171241" "SHCBP1" "hsa:79801; Q8NEM2; Q96N60; Q9BVS0; Q9H6P6" "Genetic causes of porto-sinusoidal vascular disease" "" "1" "0" "1.015" "1.061" "0.976" "1.005" "1.041" "0.854" "0.872" "0.925" "0.988" "1029.6" "1045.1" "1092.9" "1005.3" "1034.8" "1071.3" "879.2" "898.3" "952.3" "1017.4" "" "" "" "" "" "" "" "" "" "" "964.7" "864.8" "1014.6" "777.1" "882.1" "1023.5" "803.4" "797.6" "952.3" "979.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6359108141380896600" "False" "High" "IsMasterProtein" "Q86W50" "RNA N6-adenosine-methyltransferase METTL16 OS=Homo sapiens OX=9606 GN=METTL16 PE=1 SV=2" "0.000" "False" "20.044" "12" "7" "7" "7" "562" "63.6" "7.85" "21.35" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05971" "79066" "ENSG00000127804" "METTL16" "D3DTI8; hsa:79066; Q86TE5; Q86W50; Q96T16; Q9BVG7" "" "" "0" "0" "1.074" "1.014" "1.062" "1.086" "1.035" "1.029" "1.046" "0.993" "1.010" "1083.5" "1163.3" "1098.5" "1150.2" "1176.3" "1121.2" "1115.4" "1133.1" "1075.7" "1094.9" "" "" "" "" "" "" "" "" "" "" "1015.3" "962.6" "1019.8" "889.2" "1002.6" "1071.2" "1019.2" "1006.1" "1075.7" "1054.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8263203131680576726" "False" "High" "IsMasterProtein" "Cont_P13717" "Nuclease OS=Serratia marcescens OX=615 GN=nucA PE=1 SV=2" "0.000" "True" "20.038" "25" "6" "11" "6" "266" "28.9" "7.42" "37.30" "6" "" "non-structural extracellular" "nucleic acid binding activity;other molecular function" "Pf01223" "66715254" "" "nucA" "A0A2V4G0H5; A0A5C7C9X8; A0A656VIL2; P13717" "" "" "0" "0" "1.000" "0.927" "0.985" "0.991" "0.984" "0.845" "1.024" "1.012" "0.965" "1423.0" "1423.6" "1318.5" "1401.9" "1410.9" "1400.3" "1201.8" "1457.5" "1439.9" "1373.0" "" "" "" "" "" "" "" "" "" "" "1333.4" "1178.0" "1224.0" "1083.7" "1202.6" "1337.9" "1098.1" "1294.1" "1439.9" "1322.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1329067276742603011" "False" "High" "IsMasterProtein" "Q8WYP5" "Protein ELYS OS=Homo sapiens OX=9606 GN=AHCTF1 PE=1 SV=3" "0.000" "False" "20.000" "3" "7" "8" "7" "2266" "252.3" "6.60" "21.67" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf13934, Pf16687" "25909" "ENSG00000153207" "AHCTF1" "A6NGM0; A8MSG9; A8MZ86; hsa:25909; Q7Z4E3; Q8IZA4; Q8WYP5; Q96EH9; Q9Y4Q6" "Gastric cancer network 2" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "8" "0" "1.037" "1.044" "1.071" "1.099" "1.097" "1.382" "1.321" "1.307" "1.104" "334.6" "346.8" "349.2" "358.4" "367.6" "366.9" "462.3" "442.1" "437.2" "369.2" "" "" "" "" "" "" "" "" "" "" "313.5" "287.0" "324.1" "277.1" "313.3" "350.5" "422.4" "392.5" "437.2" "355.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1227550599144237947" "False" "High" "IsMasterProtein" "Q6SPF0" "Sterile alpha motif domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SAMD1 PE=1 SV=1" "0.000" "False" "19.984" "12" "6" "8" "6" "538" "56.0" "7.58" "19.69" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "other molecular function" "Pf00536, Pf21524" "90378" "ENSG00000288488" "SAMD1" "hsa:90378; Q6P0R3; Q6PIS7; Q6SPF0; Q96IM4" "" "" "0" "0" "0.969" "0.931" "0.932" "0.899" "0.871" "0.772" "0.792" "0.822" "0.895" "356.4" "345.2" "332.0" "332.3" "320.2" "310.5" "275.0" "282.4" "293.0" "318.8" "" "" "" "" "" "" "" "" "" "" "333.9" "285.7" "308.2" "256.9" "272.9" "296.6" "251.3" "250.8" "293.0" "307.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6158832266931892371" "False" "High" "IsMasterProtein" "Q01167" "Forkhead box protein K2 OS=Homo sapiens OX=9606 GN=FOXK2 PE=1 SV=3" "0.000" "False" "19.981" "12" "8" "10" "5" "660" "69.0" "9.54" "29.99" "8" "other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf00498" "3607" "ENSG00000141568" "FOXK2" "A6NEP5; hsa:3607; Q01167; Q13622; Q13623; Q13624" "" "UCH proteinases" "1" "0" "1.057" "1.023" "1.003" "0.989" "1.039" "0.994" "1.008" "1.022" "1.008" "482.2" "509.5" "493.3" "483.7" "476.7" "500.7" "479.2" "485.8" "492.6" "485.8" "" "" "" "" "" "" "" "" "" "" "451.8" "421.6" "458.0" "373.9" "406.3" "478.4" "437.9" "431.3" "492.6" "467.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "407060077554528043" "False" "High" "IsMasterProtein" "Q5T3I0" "G patch domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GPATCH4 PE=1 SV=2" "0.000" "False" "19.978" "14" "7" "8" "7" "446" "50.4" "9.63" "26.80" "7" "" "nucleus" "" "Pf01585" "" "ENSG00000292251" "GPATCH4" "Q5T3I0; Q5T3I1; Q6ZUE7; Q8IWG8; Q9NXH4" "" "" "0" "0" "1.059" "1.001" "1.136" "1.136" "1.103" "1.453" "1.428" "1.424" "1.174" "1104.2" "1168.8" "1105.2" "1254.2" "1254.4" "1218.2" "1604.7" "1576.4" "1572.7" "1296.9" "" "" "" "" "" "" "" "" "" "" "1034.6" "967.2" "1026.0" "969.6" "1069.2" "1163.9" "1466.3" "1399.6" "1572.7" "1248.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8845776874603627941" "False" "High" "IsMasterProtein" "Q92930" "Ras-related protein Rab-8B OS=Homo sapiens OX=9606 GN=RAB8B PE=1 SV=2" "0.000" "False" "19.971" "34" "7" "13" "1" "207" "23.6" "9.07" "40.22" "7" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00071" "51762" "ENSG00000166128" "RAB8B" "hsa:51762; Q5JPC4; Q92930; Q9P293" "Ectoderm differentiation; Ectoderm differentiation" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; TBC/RABGAPs" "5" "0" "0.921" "1.096" "0.986" "0.942" "1.031" "0.909" "1.236" "0.978" "0.980" "184.8" "170.3" "202.7" "182.3" "174.2" "190.7" "168.1" "228.6" "180.9" "181.1" "" "" "" "" "" "" "" "" "" "" "173.2" "140.9" "188.2" "140.9" "148.5" "182.2" "153.6" "202.9" "180.9" "174.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1080022240978719765" "False" "High" "IsMasterProtein" "P49721" "Proteasome subunit beta type-2 OS=Homo sapiens OX=9606 GN=PSMB2 PE=1 SV=1" "0.000" "False" "19.971" "30" "6" "11" "6" "201" "22.8" "7.02" "34.57" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00227" "5690" "ENSG00000126067" "PSMB2" "D3DPS0; hsa:5690; P31145; P49721; Q9BWZ9" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.925" "0.942" "1.012" "0.905" "0.922" "0.913" "0.881" "0.991" "0.913" "1395.7" "1290.6" "1315.1" "1412.6" "1262.8" "1286.4" "1273.8" "1229.8" "1382.8" "1273.7" "" "" "" "" "" "" "" "" "" "" "1307.8" "1068.0" "1220.9" "1092.0" "1076.4" "1229.0" "1163.9" "1092.0" "1382.8" "1226.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2160825122742080574" "False" "High" "IsMasterProtein" "Q13162" "Peroxiredoxin-4 OS=Homo sapiens OX=9606 GN=PRDX4 PE=1 SV=1" "0.000" "False" "19.966" "20" "6" "22" "3" "271" "30.5" "6.29" "61.05" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00578, Pf10417" "10549" "ENSG00000123131" "PRDX4" "hsa:10549; Q13162; Q6FHT3" "Selenium micronutrient network" "Neutrophil degranulation" "2" "0" "1.062" "1.083" "1.082" "1.171" "1.169" "0.960" "1.070" "1.265" "1.155" "335.7" "356.5" "363.5" "363.4" "393.1" "392.3" "322.2" "359.2" "424.7" "387.6" "" "" "" "" "" "" "" "" "" "" "314.5" "295.0" "337.4" "280.9" "335.0" "374.8" "294.4" "318.9" "424.7" "373.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2963381124708492524" "False" "High" "IsMasterProtein" "Q5JTH9" "RRP12-like protein OS=Homo sapiens OX=9606 GN=RRP12 PE=1 SV=2" "0.000" "False" "19.963" "5" "8" "8" "8" "1297" "143.6" "8.75" "16.28" "8" "RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf08161" "23223" "ENSG00000052749" "RRP12" "B4DK00; E9PCK7; hsa:23223; Q5JTH8; Q5JTH9; Q69YK4; Q96E87; Q9BUH3; Q9Y4C7" "" "" "0" "0" "1.078" "1.089" "1.182" "1.134" "1.065" "1.371" "1.326" "1.286" "1.205" "1180.4" "1272.9" "1285.1" "1394.8" "1338.1" "1257.1" "1618.9" "1565.0" "1517.8" "1422.1" "" "" "" "" "" "" "" "" "" "" "1106.1" "1053.3" "1193.1" "1078.2" "1140.5" "1201.0" "1479.2" "1389.6" "1517.8" "1369.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5608231469546375684" "False" "High" "IsMasterProtein" "O00161" "Synaptosomal-associated protein 23 OS=Homo sapiens OX=9606 GN=SNAP23 PE=1 SV=1" "0.000" "False" "19.942" "33" "6" "8" "6" "211" "23.3" "5.01" "25.97" "6" "cell-cell signaling;cell organization and biogenesis;stress response;transport" "plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00835" "8773" "ENSG00000092531" "SNAP23" "hsa:8773; O00161; O00162; Q13602; Q6IAE3" "Insulin signaling" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; ER-Phagosome pathway; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; trans-Golgi Network Vesicle Budding" "13" "0" "1.078" "0.999" "1.025" "1.006" "1.022" "0.927" "0.922" "0.895" "0.952" "960.1" "1034.8" "959.3" "984.0" "965.6" "981.4" "889.8" "884.9" "859.8" "913.9" "" "" "" "" "" "" "" "" "" "" "899.7" "856.3" "890.6" "760.7" "823.1" "937.6" "813.0" "785.7" "859.8" "880.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8115328096255325213" "False" "High" "IsMasterProtein" "P29966" "Myristoylated alanine-rich C-kinase substrate OS=Homo sapiens OX=9606 GN=MARCKS PE=1 SV=4" "0.000" "False" "19.941" "26" "5" "5" "5" "332" "31.5" "4.45" "24.21" "5" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02063" "4082" "ENSG00000277443" "MARCKS" "E1P560; hsa:4082; P29966; Q2LA83; Q5TDB7" "Brain-derived neurotrophic factor (BDNF) signaling pathway" "Acetylcholine regulates insulin secretion" "2" "0" "1.102" "1.007" "1.060" "1.045" "1.052" "0.998" "1.050" "1.020" "1.070" "1026.6" "1131.4" "1033.6" "1088.1" "1072.9" "1079.8" "1024.2" "1078.2" "1046.8" "1098.9" "" "" "" "" "" "" "" "" "" "" "961.9" "936.3" "959.6" "841.1" "914.5" "1031.7" "935.9" "957.3" "1046.8" "1058.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3716051439609727834" "False" "High" "IsMasterProtein" "Q9NW82" "WD repeat-containing protein 70 OS=Homo sapiens OX=9606 GN=WDR70 PE=1 SV=1" "0.000" "False" "19.929" "12" "8" "10" "8" "654" "73.2" "6.33" "28.03" "8" "" "nucleus;other cell component" "other molecular function" "Pf00400" "55100" "ENSG00000082068" "WDR70" "hsa:55100; Q9H053; Q9NW82" "" "mRNA Splicing - Major Pathway" "1" "0" "1.002" "1.051" "0.988" "1.026" "1.009" "1.004" "0.968" "0.992" "1.008" "1807.1" "1811.5" "1898.9" "1786.2" "1854.3" "1824.0" "1815.1" "1748.6" "1793.0" "1822.2" "" "" "" "" "" "" "" "" "" "" "1693.3" "1499.0" "1762.9" "1380.8" "1580.6" "1742.7" "1658.5" "1552.6" "1793.0" "1754.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491921153129945541" "False" "High" "IsMasterProtein" "Q9UHV9" "Prefoldin subunit 2 OS=Homo sapiens OX=9606 GN=PFDN2 PE=1 SV=1" "0.000" "False" "19.897" "44" "6" "7" "6" "154" "16.6" "6.58" "24.01" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01920" "5202" "ENSG00000143256" "PFDN2" "hsa:5202; Q9P0P7; Q9UHV9; Q9UN05" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "1.149" "1.152" "1.221" "0.993" "0.790" "0.872" "0.985" "0.955" "1.026" "1308.5" "1503.0" "1507.5" "1597.0" "1299.7" "1033.6" "1141.5" "1289.2" "1249.0" "1342.1" "" "" "" "" "" "" "" "" "" "" "1226.0" "1243.7" "1399.6" "1234.6" "1107.8" "987.5" "1043.1" "1144.7" "1249.0" "1292.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7356302297912569782" "False" "High" "IsMasterProtein" "O75400" "Pre-mRNA-processing factor 40 homolog A OS=Homo sapiens OX=9606 GN=PRPF40A PE=1 SV=2" "0.000" "False" "19.894" "7" "7" "7" "7" "957" "108.7" "7.56" "21.94" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf00397, Pf01846" "55660" "ENSG00000196504" "PRPF40A" "hsa:55660; O43856; O75400; O75404; Q8TBQ1; Q9H782; Q9NWU9; Q9P0Q2; Q9Y5A8" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.108" "1.086" "1.024" "0.978" "0.944" "0.891" "0.904" "0.951" "1.000" "663.2" "735.0" "720.0" "679.4" "648.9" "626.0" "590.9" "599.4" "631.0" "663.5" "" "" "" "" "" "" "" "" "" "" "621.4" "608.2" "668.5" "525.2" "553.1" "598.1" "539.9" "532.2" "631.0" "638.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7527974897574347786" "False" "High" "IsMasterProtein" "Q16778" "Histone H2B type 2-E OS=Homo sapiens OX=9606 GN=H2BC21 PE=1 SV=3" "0.000" "False" "19.843" "52" "7" "24" "1" "126" "13.9" "10.32" "70.39" "7" "cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "8349" "ENSG00000184678" "H2BC21" "A3KMC7; A8K110; hsa:8349; Q16778; Q4KMY1; Q5QNX0; Q9UE88" "" "Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression; HATs acetylate histones; Amyloid fiber formation; Meiotic synapsis; HCMV Late Events; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Early Events; Transcriptional regulation by small RNAs; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Replacement of protamines by nucleosomes in the male pronucleus" "44" "6" "1.008" "1.094" "1.059" "1.034" "1.021" "1.102" "1.015" "1.097" "1.056" "1866.2" "1881.3" "2041.7" "1976.1" "1929.5" "1905.0" "2056.2" "1894.0" "2046.9" "1971.0" "" "" "" "" "" "" "" "" "" "" "1748.6" "1556.8" "1895.4" "1527.6" "1644.6" "1820.1" "1878.8" "1681.7" "2046.9" "1897.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "350297391460659300" "False" "High" "IsMasterProtein" "Q96CT7" "Coiled-coil domain-containing protein 124 OS=Homo sapiens OX=9606 GN=CCDC124 PE=1 SV=1" "0.000" "False" "19.832" "29" "7" "10" "7" "223" "25.8" "9.54" "28.55" "7" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06244" "115098" "ENSG00000007080" "CCDC124" "hsa:115098; Q96CT7" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.084" "1.010" "1.112" "1.199" "1.175" "1.182" "1.253" "1.199" "1.130" "1886.5" "2045.3" "1906.1" "2097.7" "2261.4" "2216.1" "2229.3" "2364.7" "2261.4" "2131.0" "" "" "" "" "" "" "" "" "" "" "1767.7" "1692.4" "1769.5" "1621.6" "1927.6" "2117.3" "2037.0" "2099.6" "2261.4" "2051.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6076185631256904569" "False" "High" "IsMasterProtein" "Q9P016" "Thymocyte nuclear protein 1 OS=Homo sapiens OX=9606 GN=THYN1 PE=1 SV=1" "0.000" "False" "19.831" "28" "7" "10" "7" "225" "25.7" "9.25" "28.65" "7" "" "" "" "Pf01878" "29087" "ENSG00000151500" "THYN1" "hsa:29087; Q567Q2; Q9H3L4; Q9HC20; Q9P016" "" "" "0" "0" "1.054" "0.995" "1.000" "1.000" "0.988" "1.043" "0.968" "0.992" "1.008" "1749.9" "1843.9" "1740.7" "1749.8" "1750.2" "1729.2" "1825.0" "1693.9" "1736.2" "1763.9" "" "" "" "" "" "" "" "" "" "" "1639.7" "1525.8" "1616.0" "1352.7" "1491.8" "1652.1" "1667.6" "1504.0" "1736.2" "1698.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3331703410720076251" "False" "High" "IsMasterProtein" "Q96BN8" "Ubiquitin thioesterase otulin OS=Homo sapiens OX=9606 GN=OTULIN PE=1 SV=3" "0.000" "False" "19.818" "21" "8" "10" "8" "352" "40.2" "5.47" "25.65" "8" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf16218" "90268" "ENSG00000154124" "OTULIN" "D3DTD3; hsa:90268; Q8NAS0; Q96BN8; Q96IA3" "" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Regulation of TNFR1 signaling" "2" "0" "0.913" "0.960" "0.978" "0.952" "0.971" "0.970" "0.939" "0.944" "1.002" "1888.8" "1725.4" "1812.5" "1846.9" "1797.3" "1834.3" "1832.0" "1774.1" "1783.7" "1892.3" "" "" "" "" "" "" "" "" "" "" "1769.8" "1427.7" "1682.7" "1427.7" "1532.0" "1752.5" "1674.0" "1575.2" "1783.7" "1822.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-849081801659546262" "False" "High" "IsMasterProtein" "P30533" "Alpha-2-macroglobulin receptor-associated protein OS=Homo sapiens OX=9606 GN=LRPAP1 PE=1 SV=1" "0.000" "False" "19.796" "21" "9" "12" "9" "357" "41.4" "8.78" "30.99" "9" "transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf06400, Pf06401" "4043" "ENSG00000163956" "LRPAP1" "D3DVR9; hsa:4043; P30533; Q2M310; Q53HQ3; Q53HS6" "Cholesterol metabolism" "" "1" "0" "1.093" "0.978" "1.075" "1.099" "1.060" "1.060" "1.084" "0.984" "1.063" "1014.2" "1108.1" "991.6" "1090.5" "1114.7" "1075.3" "1075.5" "1099.4" "997.8" "1077.9" "" "" "" "" "" "" "" "" "" "" "950.3" "916.9" "920.6" "843.0" "950.1" "1027.4" "982.7" "976.1" "997.8" "1037.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3980690536672084448" "False" "High" "IsMasterProtein" "Q8NHV4" "Protein NEDD1 OS=Homo sapiens OX=9606 GN=NEDD1 PE=1 SV=1" "0.000" "False" "19.786" "12" "7" "7" "7" "660" "71.9" "7.97" "24.32" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00400" "121441" "ENSG00000139350" "NEDD1" "B0AZN0; B4E145; G3V3F1; hsa:121441; Q8NA30; Q8NHV4" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "1.032" "1.003" "1.036" "1.060" "1.032" "1.051" "1.039" "1.030" "1.026" "1789.5" "1846.9" "1794.9" "1854.7" "1896.7" "1845.9" "1880.6" "1859.0" "1843.7" "1836.3" "" "" "" "" "" "" "" "" "" "" "1676.7" "1528.3" "1666.4" "1433.8" "1616.7" "1763.6" "1718.3" "1650.6" "1843.7" "1768.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5909232235632679983" "False" "High" "IsMasterProtein" "Q13418" "Integrin-linked protein kinase OS=Homo sapiens OX=9606 GN=ILK PE=1 SV=2" "0.000" "False" "19.782" "17" "8" "10" "8" "452" "51.4" "8.07" "25.84" "8" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "kinase activity;other molecular function" "Pf07714, Pf12796" "3611" "ENSG00000166333" "ILK" "B7Z1I0; B7Z418; D3DQU0; hsa:3611; P57043; Q13418; Q68DZ3" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; PPAR signaling pathway; Eukaryotic transcription initiation; Endometrial cancer; Acute viral myocarditis; Genes controlling nephrogenesis; Development of ureteric collection system; 2q37 copy number variation syndrome" "Localization of the PINCH-ILK-PARVIN complex to focal adhesions" "13" "0" "1.005" "1.028" "1.040" "1.045" "1.037" "1.024" "1.045" "0.989" "1.044" "1465.7" "1472.9" "1506.4" "1524.2" "1531.6" "1519.5" "1500.1" "1531.3" "1450.2" "1529.7" "" "" "" "" "" "" "" "" "" "" "1373.3" "1218.8" "1398.5" "1178.2" "1305.5" "1451.7" "1370.7" "1359.7" "1450.2" "1472.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6385363124040609264" "False" "High" "IsMasterProtein" "Q13217" "DnaJ homolog subfamily C member 3 OS=Homo sapiens OX=9606 GN=DNAJC3 PE=1 SV=1" "0.000" "False" "19.752" "13" "8" "10" "8" "504" "57.5" "6.15" "33.90" "8" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00226, Pf00515, Pf13181" "5611" "ENSG00000102580" "DNAJC3" "hsa:5611; Q13217; Q86WT9; Q8N4N2" "Photodynamic therapy-induced unfolded protein response" "Neutrophil degranulation; Viral mRNA Translation; PKR-mediated signaling; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes" "7" "0" "0.999" "1.014" "1.019" "1.081" "1.091" "1.015" "0.963" "1.032" "1.046" "1828.7" "1827.5" "1853.6" "1862.6" "1975.9" "1995.3" "1855.7" "1760.2" "1887.3" "1912.4" "" "" "" "" "" "" "" "" "" "" "1713.4" "1512.2" "1720.9" "1439.9" "1684.2" "1906.3" "1695.6" "1562.9" "1887.3" "1841.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8357658854123366068" "False" "High" "IsMasterProtein" "O00629" "Importin subunit alpha-3 OS=Homo sapiens OX=9606 GN=KPNA4 PE=1 SV=1" "0.000" "False" "19.734" "13" "7" "8" "3" "521" "57.9" "4.96" "28.95" "7" "cell-cell signaling;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3840" "ENSG00000186432" "KPNA4" "A8K4S6; D3DNM2; hsa:3840; O00190; O00629" "Leptin signaling pathway" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways" "3" "0" "0.974" "0.939" "1.013" "0.888" "0.915" "0.904" "0.910" "0.820" "0.948" "195.1" "190.1" "183.2" "197.7" "173.2" "178.6" "176.3" "177.5" "160.0" "185.0" "" "" "" "" "" "" "" "" "" "" "182.8" "157.3" "170.1" "152.8" "147.6" "170.6" "161.1" "157.6" "160.0" "178.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8332128719972757989" "False" "High" "IsMasterProtein" "Q8IY67" "Ribonucleoprotein PTB-binding 1 OS=Homo sapiens OX=9606 GN=RAVER1 PE=1 SV=1" "0.000" "False" "19.729" "12" "6" "7" "6" "606" "63.8" "8.48" "26.16" "6" "" "nucleus;other cell component" "" "Pf00076" "125950" "" "RAVER1" "A6NMU4; hsa:125950; Q8IY60; Q8IY67; Q8TF24" "" "" "0" "0" "1.003" "1.022" "0.931" "1.035" "1.013" "0.909" "0.953" "0.892" "1.025" "549.0" "550.9" "561.3" "511.1" "568.5" "556.3" "499.3" "523.4" "489.6" "562.5" "" "" "" "" "" "" "" "" "" "" "514.4" "455.9" "521.1" "395.1" "484.6" "531.5" "456.2" "464.7" "489.6" "541.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "777273144622755670" "False" "High" "IsMasterProtein" "P51649" "Succinate-semialdehyde dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH5A1 PE=1 SV=2" "0.000" "False" "19.718" "10" "7" "9" "7" "535" "57.2" "8.28" "23.15" "7" "cell-cell signaling;other metabolic processes;developmental processes" "mitochondrion;other cell component" "other molecular function" "Pf00171" "7915" "ENSG00000112294" "ALDH5A1" "B2RD26; G5E949; hsa:7915; P51649; Q546H9; Q8N3W6" "Fragile X syndrome" "Degradation of GABA" "2" "0" "1.051" "1.050" "1.090" "1.070" "1.042" "1.081" "1.021" "1.004" "1.074" "729.8" "767.1" "766.0" "795.6" "780.5" "760.5" "788.5" "745.1" "733.0" "783.4" "" "" "" "" "" "" "" "" "" "" "683.8" "634.7" "711.1" "615.1" "665.3" "726.6" "720.5" "661.6" "733.0" "754.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4369435830510499583" "False" "High" "IsMasterProtein" "Q9GZP4" "PITH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PITHD1 PE=1 SV=1" "0.000" "False" "19.698" "33" "7" "11" "7" "211" "24.2" "5.74" "31.55" "7" "other biological processes" "other cell component" "" "Pf06201" "57095" "ENSG00000057757" "PITHD1" "B2R7J4; hsa:57095; Q5QPN6; Q5QPN7; Q9GZP4; Q9NRI8" "" "" "0" "0" "0.977" "0.970" "0.960" "0.930" "1.001" "0.889" "1.001" "1.007" "1.004" "1059.8" "1035.4" "1028.4" "1017.4" "985.7" "1060.6" "942.0" "1061.2" "1067.0" "1064.0" "" "" "" "" "" "" "" "" "" "" "993.1" "856.8" "954.7" "786.5" "840.2" "1013.3" "860.7" "942.3" "1067.0" "1024.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2765435694013910926" "False" "High" "IsMasterProtein" "Q96Q15" "Serine/threonine-protein kinase SMG1 OS=Homo sapiens OX=9606 GN=SMG1 PE=1 SV=3" "0.000" "False" "19.667" "2" "7" "7" "7" "3661" "410.2" "6.46" "18.57" "7" "protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02260, Pf15785, Pf17229" "23049" "ENSG00000157106" "SMG1" "hsa:23049; O43305; Q13284; Q8NFX2; Q96Q15; Q96QV0; Q96RW3" "" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "1" "0" "0.950" "0.976" "1.027" "0.992" "0.957" "0.993" "0.903" "0.920" "1.039" "280.2" "266.2" "273.3" "287.8" "277.9" "268.3" "278.3" "253.0" "257.7" "291.2" "" "" "" "" "" "" "" "" "" "" "262.5" "220.3" "253.8" "222.5" "236.9" "256.3" "254.3" "224.6" "257.7" "280.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6459362278607736604" "False" "High" "IsMasterProtein" "Q9HB07" "MYG1 exonuclease OS=Homo sapiens OX=9606 GN=MYG1 PE=1 SV=4" "0.000" "False" "19.659" "19" "6" "6" "6" "376" "42.5" "6.84" "17.56" "6" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf03690" "60314" "ENSG00000139637; ENSG00000291835" "MYG1" "hsa:60314; Q86UA3; Q9HB07" "" "" "0" "0" "0.931" "0.977" "1.063" "0.959" "0.952" "0.978" "1.002" "0.929" "0.982" "652.2" "607.0" "637.1" "693.4" "625.3" "620.8" "638.1" "653.8" "606.1" "640.3" "" "" "" "" "" "" "" "" "" "" "611.1" "502.3" "591.4" "536.0" "533.0" "593.1" "583.0" "580.5" "606.1" "616.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5142259406840293622" "False" "High" "IsMasterProtein" "Q14738" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform OS=Homo sapiens OX=9606 GN=PPP2R5D PE=1 SV=1" "0.000" "False" "19.650" "14" "8" "8" "8" "602" "69.9" "8.13" "23.63" "8" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01603" "5528" "ENSG00000112640" "PPP2R5D" "A8K3I9; B5BUA6; hsa:5528; O00494; O00696; Q14738; Q15171; Q5TC39" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "RAF activation; Negative regulation of MAPK pathway; Separation of Sister Chromatids; DARPP-32 events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Platelet sensitization by LDL; CTLA4 inhibitory signaling; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "33" "0" "0.965" "1.011" "1.046" "1.033" "1.014" "0.988" "1.018" "1.058" "1.035" "1485.7" "1434.4" "1502.4" "1554.7" "1535.1" "1506.7" "1468.6" "1512.1" "1571.5" "1537.6" "" "" "" "" "" "" "" "" "" "" "1392.1" "1186.9" "1394.8" "1201.8" "1308.4" "1439.5" "1341.9" "1342.6" "1571.5" "1480.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9189590484777075943" "False" "High" "IsMasterProtein" "Q13185" "Chromobox protein homolog 3 OS=Homo sapiens OX=9606 GN=CBX3 PE=1 SV=4" "0.000" "False" "19.645" "32" "6" "17" "5" "183" "20.8" "5.33" "59.43" "6" "cell organization and biogenesis;stress response;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00385, Pf01393" "11335" "ENSG00000122565" "CBX3" "hsa:11335; Q13185; Q96CD7; Q99409; Q9BVS3; Q9P0Z6" "Exercise-induced circadian regulation; Effect of progerin on genes involved in progeria; NIPBL role in DNA damage - Cornelia de Lange syndrome" "RNA Polymerase I Promoter Escape; Transcriptional Regulation by E2F6; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" "6" "1" "1.134" "1.069" "1.128" "1.044" "1.063" "1.063" "1.096" "0.979" "1.079" "1191.3" "1351.2" "1273.7" "1344.3" "1243.6" "1265.9" "1266.3" "1305.8" "1166.2" "1285.1" "" "" "" "" "" "" "" "" "" "" "1116.2" "1118.1" "1182.5" "1039.2" "1060.0" "1209.4" "1157.1" "1159.4" "1166.2" "1237.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4286277691384661774" "False" "High" "IsMasterProtein" "Q6P1X5" "Transcription initiation factor TFIID subunit 2 OS=Homo sapiens OX=9606 GN=TAF2 PE=1 SV=3" "0.000" "False" "19.642" "7" "9" "10" "9" "1199" "136.9" "8.19" "29.49" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "6873" "ENSG00000064313" "TAF2" "B2RE82; hsa:6873; O43487; O43604; O60668; Q6P1X5; Q86WW7; Q8IWK4" "" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "9" "0" "1.106" "0.990" "1.021" "0.815" "0.779" "0.776" "0.950" "0.835" "0.773" "375.4" "415.1" "371.6" "383.2" "306.1" "292.4" "291.4" "356.7" "313.5" "290.1" "" "" "" "" "" "" "" "" "" "" "351.8" "343.5" "344.9" "296.2" "260.9" "279.4" "266.3" "316.7" "313.5" "279.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3178523695898665962" "False" "High" "IsMasterProtein" "Q9NYF8" "Bcl-2-associated transcription factor 1 OS=Homo sapiens OX=9606 GN=BCLAF1 PE=1 SV=2" "0.000" "False" "19.640" "8" "8" "9" "7" "920" "106.1" "9.98" "28.26" "8" "stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15440" "9774" "ENSG00000029363" "BCLAF1" "A2RU75; B7ZM58; E1P586; hsa:9774; Q14673; Q86WU6; Q86WY0; Q9NYF8" "Interactome of polycomb repressive complex 2 (PRC2)" "" "1" "0" "1.102" "0.960" "1.039" "1.043" "1.005" "1.396" "1.486" "1.422" "1.137" "1883.0" "2074.2" "1807.0" "1955.6" "1963.5" "1892.2" "2627.9" "2797.5" "2677.2" "2140.5" "" "" "" "" "" "" "" "" "" "" "1764.3" "1716.4" "1677.6" "1511.8" "1673.7" "1807.8" "2401.2" "2483.9" "2677.2" "2061.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1068600970013118283" "False" "High" "IsMasterProtein" "Q99584" "Protein S100-A13 OS=Homo sapiens OX=9606 GN=S100A13 PE=1 SV=1" "0.000" "False" "19.636" "48" "5" "10" "5" "98" "11.5" "6.16" "33.23" "5" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01023" "6284" "ENSG00000189171" "S100A13" "hsa:6284; Q52PI9; Q6FGF8; Q99584" "" "" "0" "0" "1.073" "1.036" "0.975" "1.014" "1.031" "1.034" "1.052" "1.000" "0.998" "1862.6" "1999.0" "1930.4" "1816.4" "1889.1" "1920.4" "1925.8" "1959.4" "1863.1" "1858.0" "" "" "" "" "" "" "" "" "" "" "1745.3" "1654.1" "1792.1" "1404.2" "1610.2" "1834.7" "1759.7" "1739.8" "1863.1" "1789.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3137341147702067960" "False" "High" "IsMasterProtein" "P26440" "Isovaleryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=IVD PE=1 SV=2" "0.000" "False" "19.630" "20" "7" "9" "7" "426" "46.6" "8.05" "27.48" "7" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00441, Pf02770, Pf02771" "3712" "ENSG00000128928" "IVD" "B2RCV5; B3KVI7; hsa:3712; J3KR54; P26440; Q53XZ9; Q96AF6" "Valproic acid pathway" "Branched-chain amino acid catabolism" "2" "0" "0.977" "1.010" "0.979" "0.979" "1.001" "0.927" "0.983" "0.981" "0.980" "1247.5" "1218.6" "1259.8" "1221.2" "1220.8" "1248.9" "1156.2" "1226.6" "1223.8" "1222.8" "" "" "" "" "" "" "" "" "" "" "1168.9" "1008.4" "1169.6" "944.0" "1040.6" "1193.2" "1056.5" "1089.1" "1223.8" "1177.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174444924925407144" "False" "High" "IsMasterProtein" "P61088" "Ubiquitin-conjugating enzyme E2 N OS=Homo sapiens OX=9606 GN=UBE2N PE=1 SV=1" "0.000" "False" "19.621" "40" "6" "14" "6" "152" "17.1" "6.57" "43.76" "6" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00179" "7334" "ENSG00000177889" "UBE2N" "hsa:7334; P61088; Q16781; Q53Y81" "IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway; Prader-Willi and Angelman syndrome; 3q29 copy number variation syndrome" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; Aggrephagy; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; Nonhomologous End-Joining (NHEJ); Formation of Incision Complex in GG-NER; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "28" "0" "0.963" "0.986" "1.054" "1.014" "1.053" "1.002" "1.033" "0.972" "0.964" "1354.7" "1304.5" "1335.1" "1428.4" "1374.1" "1426.4" "1357.2" "1399.3" "1316.8" "1306.4" "" "" "" "" "" "" "" "" "" "" "1269.4" "1079.5" "1239.5" "1104.2" "1171.3" "1362.8" "1240.2" "1242.5" "1316.8" "1257.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7242737941757580841" "False" "High" "IsMasterProtein" "P54105" "Methylosome subunit pICln OS=Homo sapiens OX=9606 GN=CLNS1A PE=1 SV=1" "0.000" "False" "19.602" "31" "4" "6" "4" "237" "26.2" "4.11" "24.98" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf03517" "1207" "ENSG00000074201" "CLNS1A" "B2RCS9; hsa:1207; P54105; Q0VDK6; Q9NRD2; Q9NRD3" "" "snRNP Assembly" "1" "0" "1.050" "1.094" "1.090" "1.171" "1.142" "1.061" "1.104" "1.139" "1.128" "698.7" "733.3" "764.6" "761.3" "818.0" "797.9" "741.4" "771.6" "795.6" "788.0" "" "" "" "" "" "" "" "" "" "" "654.6" "606.8" "709.9" "588.5" "697.2" "762.4" "677.5" "685.1" "795.6" "758.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3867715510256549408" "False" "High" "IsMasterProtein" "P49757" "Protein numb homolog OS=Homo sapiens OX=9606 GN=NUMB PE=1 SV=2" "0.000" "False" "19.600" "10" "6" "6" "6" "651" "70.8" "8.51" "19.41" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00640, Pf06311" "8650" "ENSG00000133961" "NUMB" "B1P2N5; B1P2N6; B1P2N7; B1P2N8; B1P2N9; B4E2B1; hsa:8650; P49757; Q6NUQ7; Q86SY1; Q8WW73; Q9UBG1; Q9UEQ4; Q9UKE8; Q9UKE9; Q9UKF0; Q9UQJ4" "Notch signaling; VEGFA-VEGFR2 signaling; Head and neck squamous cell carcinoma; Neurogenesis regulation in the olfactory epithelium; TROP2 regulatory signaling; Notch signaling pathway" "Recycling pathway of L1; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus" "10" "0" "0.963" "0.982" "1.061" "0.984" "1.031" "0.975" "0.970" "0.966" "0.986" "595.0" "572.9" "584.1" "631.0" "585.2" "613.2" "580.1" "577.1" "575.1" "586.6" "" "" "" "" "" "" "" "" "" "" "557.5" "474.1" "542.3" "487.8" "498.8" "585.8" "530.1" "512.4" "575.1" "564.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7478524853152137733" "False" "High" "IsMasterProtein" "P43487" "Ran-specific GTPase-activating protein OS=Homo sapiens OX=9606 GN=RANBP1 PE=1 SV=1" "0.000" "False" "19.593" "19" "4" "10" "4" "201" "23.3" "5.29" "28.18" "4" "transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00638" "5902" "ENSG00000099901" "RANBP1" "hsa:5902; P43487; Q53EY3" "22q11.2 copy number variation syndrome" "Rev-mediated nuclear export of HIV RNA" "2" "0" "1.054" "0.996" "0.968" "0.913" "0.863" "0.911" "0.944" "0.860" "0.872" "1570.1" "1654.1" "1563.1" "1519.6" "1433.9" "1354.7" "1429.7" "1482.2" "1350.7" "1368.5" "" "" "" "" "" "" "" "" "" "" "1471.2" "1368.7" "1451.1" "1174.7" "1222.2" "1294.3" "1306.4" "1316.0" "1350.7" "1317.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7629254407620291846" "False" "High" "IsMasterProtein" "Q15428" "Splicing factor 3A subunit 2 OS=Homo sapiens OX=9606 GN=SF3A2 PE=1 SV=2" "0.000" "False" "19.590" "12" "6" "15" "6" "464" "49.2" "9.64" "34.54" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf12874, Pf16835" "8175" "ENSG00000104897" "SF3A2" "B2RBU1; D6W605; hsa:8175; O75245; Q15428" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.992" "1.004" "0.915" "1.044" "1.031" "1.118" "1.078" "1.109" "1.024" "453.9" "450.1" "455.7" "415.4" "473.8" "468.0" "507.2" "489.4" "503.4" "464.9" "" "" "" "" "" "" "" "" "" "" "425.3" "372.5" "423.1" "321.1" "403.8" "447.1" "463.5" "434.6" "503.4" "447.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7912852613905627854" "False" "High" "IsMasterProtein" "Q01196" "Runt-related transcription factor 1 OS=Homo sapiens OX=9606 GN=RUNX1 PE=1 SV=3" "0.000" "False" "19.538" "16" "7" "11" "7" "453" "48.7" "9.35" "32.19" "7" "cell cycle OR cell proliferation;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00853, Pf08504" "861" "ENSG00000159216" "RUNX1" "A8MV94; B2RMS4; D3DSG1; hsa:861; O60472; O60473; O76047; O76089; Q01196; Q13081; Q13755; Q13756; Q13757; Q13758; Q13759; Q15341; Q15343; Q16122; Q16284; Q16285; Q16286; Q16346; Q16347; Q92479" "Hematopoietic stem cell differentiation; Dual hijack model of Vif in HIV infection; Orexin receptor pathway; Th17 cell differentiation pathway; Acute myeloid leukemia" "Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RUNX1 regulates expression of components of tight junctions; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates estrogen receptor mediated transcription; RUNX1 regulates transcription of genes involved in WNT signaling; Organic cation transport; SARS-CoV-1 activates/modulates innate immune responses; Transcriptional regulation of granulopoiesis; RUNX3 regulates p14-ARF; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs); RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in interleukin signaling; Regulation of RUNX1 Expression and Activity; RUNX2 regulates genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in BCR signaling" "24" "0" "1.105" "1.082" "1.012" "1.090" "1.107" "0.987" "1.032" "1.003" "1.036" "391.4" "432.3" "423.5" "395.9" "426.6" "433.3" "386.2" "403.9" "392.5" "405.6" "" "" "" "" "" "" "" "" "" "" "366.7" "357.7" "393.2" "306.1" "363.6" "414.0" "352.9" "358.6" "392.5" "390.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-366099160936262297" "False" "High" "IsMasterProtein" "Q9NQG5" "Regulation of nuclear pre-mRNA domain-containing protein 1B OS=Homo sapiens OX=9606 GN=RPRD1B PE=1 SV=1" "0.000" "False" "19.530" "21" "6" "7" "6" "326" "36.9" "5.97" "26.19" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04818, Pf16566" "58490" "ENSG00000101413" "RPRD1B" "hsa:58490; Q1WDE7; Q6PKF4; Q9NQG5" "Modulators of TCR signaling and T cell activation" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.063" "1.049" "1.176" "1.201" "1.171" "1.157" "1.107" "1.132" "1.068" "561.8" "597.1" "589.5" "660.6" "674.7" "657.7" "649.8" "622.0" "635.7" "599.7" "" "" "" "" "" "" "" "" "" "" "526.4" "494.1" "547.2" "510.6" "575.1" "628.3" "593.7" "552.3" "635.7" "577.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7820543804174258540" "False" "High" "IsMasterProtein" "P00374" "Dihydrofolate reductase OS=Homo sapiens OX=9606 GN=DHFR PE=1 SV=2" "0.000" "False" "19.524" "37" "7" "13" "7" "187" "21.4" "7.42" "33.74" "7" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00186" "1719" "ENSG00000228716" "DHFR" "B4DDD2; hsa:1719; P00374; Q14130; Q6IRW8" "Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration, one-carbon metabolism and related pathways; Ethanol effects on histone modifications" "G1/S-Specific Transcription; Metabolism of folate and pterines; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "9" "0" "0.973" "0.958" "0.919" "0.935" "0.945" "0.867" "0.874" "0.919" "0.957" "1807.5" "1758.6" "1730.9" "1660.5" "1690.0" "1707.7" "1567.5" "1580.2" "1661.5" "1729.8" "" "" "" "" "" "" "" "" "" "" "1693.6" "1455.3" "1606.9" "1283.7" "1440.5" "1631.6" "1432.3" "1403.1" "1661.5" "1665.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4243643898250283401" "False" "High" "IsMasterProtein" "Q9UI08" "Ena/VASP-like protein OS=Homo sapiens OX=9606 GN=EVL PE=1 SV=2" "0.000" "False" "19.494" "21" "7" "12" "6" "416" "44.6" "8.84" "26.86" "7" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "51466" "ENSG00000196405" "EVL" "A8K105; B7Z3I5; hsa:51466; O95884; Q7Z522; Q8TBV1; Q9UF25; Q9UI08; Q9UIC2" "" "Generation of second messenger molecules; RHO GTPases Activate Formins; Signaling by ROBO receptors" "3" "0" "0.920" "0.922" "1.005" "0.975" "0.928" "0.985" "0.950" "0.902" "0.994" "413.4" "380.2" "381.1" "415.6" "403.1" "383.6" "407.3" "392.9" "372.9" "411.1" "" "" "" "" "" "" "" "" "" "" "387.4" "314.6" "353.8" "321.3" "343.6" "366.5" "372.2" "348.9" "372.9" "395.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "965973480370309944" "False" "High" "IsMasterProtein" "Q53HC9" "EARP and GARP complex-interacting protein 1 OS=Homo sapiens OX=9606 GN=EIPR1 PE=1 SV=2" "0.000" "False" "19.484" "19" "6" "7" "6" "387" "43.6" "5.06" "25.01" "6" "protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi" "" "Pf00400" "7260" "ENSG00000032389" "EIPR1" "D6W4Y1; hsa:7260; O43179; Q53HC9; Q53S19; Q53SG2" "Ciliary landscape" "" "1" "0" "0.968" "1.021" "0.963" "0.978" "0.968" "0.899" "0.960" "0.939" "0.967" "795.3" "769.9" "812.4" "765.5" "777.6" "770.0" "715.1" "763.1" "747.1" "768.8" "" "" "" "" "" "" "" "" "" "" "745.2" "637.1" "754.2" "591.8" "662.8" "735.7" "653.4" "677.6" "747.1" "740.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6201262043542307507" "False" "High" "IsMasterProtein" "P34896" "Serine hydroxymethyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=SHMT1 PE=1 SV=1" "0.000" "False" "19.474" "14" "6" "10" "5" "483" "53.0" "7.71" "30.91" "6" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00464" "6470" "ENSG00000176974; ENSG00000284320" "SHMT1" "B4DPM9; D3DXD0; hsa:6470; P34896; Q96HY0; Q9UMD1; Q9UMD2" "Glycine metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Male infertility; Neuroinflammation and glutamatergic signaling; Spina bifida; Metabolic Epileptic Disorders; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Metabolism of folate and pterines; Carnitine synthesis" "13" "0" "0.957" "1.032" "0.940" "0.971" "1.021" "0.874" "0.915" "0.995" "0.997" "627.4" "600.2" "647.7" "590.0" "609.0" "640.4" "548.2" "574.1" "624.2" "625.5" "" "" "" "" "" "" "" "" "" "" "587.8" "496.7" "601.3" "456.1" "519.1" "611.8" "500.9" "509.7" "624.2" "602.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2945964816553277045" "False" "High" "IsMasterProtein" "Q9Y2X0" "Mediator of RNA polymerase II transcription subunit 16 OS=Homo sapiens OX=9606 GN=MED16 PE=1 SV=2" "0.000" "False" "19.465" "8" "8" "10" "8" "877" "96.7" "7.37" "24.59" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00400, Pf11635, Pf20718, Pf20719" "10025" "ENSG00000175221" "MED16" "hsa:10025; Q6PJT2; Q96AD4; Q96I35; Q9Y2X0; Q9Y652" "" "Generic Transcription Pathway; Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; RSV-host interactions" "4" "0" "1.026" "0.978" "1.114" "1.068" "0.996" "1.160" "1.002" "1.027" "0.983" "330.7" "339.3" "323.4" "368.5" "353.1" "329.2" "383.7" "331.5" "339.5" "325.1" "" "" "" "" "" "" "" "" "" "" "309.9" "280.8" "300.2" "284.9" "301.0" "314.6" "350.6" "294.3" "339.5" "313.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-750359377190588192" "False" "High" "IsMasterProtein" "O75616" "GTPase Era, mitochondrial OS=Homo sapiens OX=9606 GN=ERAL1 PE=1 SV=2" "0.000" "False" "19.449" "15" "5" "7" "5" "437" "48.3" "8.84" "22.74" "5" "cell organization and biogenesis" "other membranes;cytosol;mitochondrion" "translation activity;nucleic acid binding activity;other molecular function" "Pf01926" "26284" "ENSG00000132591" "ERAL1" "B3KN21; C9JEC6; hsa:26284; O75616; O75617; Q8WUY4; Q96LE2; Q96TC0" "Primary ovarian insufficiency" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "1.029" "1.001" "1.101" "1.100" "1.098" "1.069" "0.990" "1.016" "1.048" "587.0" "604.2" "587.5" "646.1" "645.6" "644.3" "627.7" "581.0" "596.5" "615.4" "" "" "" "" "" "" "" "" "" "" "550.0" "500.0" "545.4" "499.5" "550.3" "615.6" "573.6" "515.8" "596.5" "592.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-464578960870386636" "False" "High" "IsMasterProtein" "O43639" "Cytoplasmic protein NCK2 OS=Homo sapiens OX=9606 GN=NCK2 PE=1 SV=2" "0.000" "False" "19.443" "17" "7" "10" "5" "380" "42.9" "6.95" "21.38" "7" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00018, Pf14604" "8440" "ENSG00000071051" "NCK2" "D3DVK1; hsa:8440; O43639; Q9BWN9; Q9UIC3" "Pathogenic Escherichia coli infection; Brain-derived neurotrophic factor (BDNF) signaling pathway; EGF/EGFR signaling pathway; Genes controlling nephrogenesis; ErbB signaling pathway" "RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Downstream signal transduction; VEGFA-VEGFR2 Pathway; Ephrin signaling; Activation of RAC1; Regulation of cortical dendrite branching" "13" "1" "0.991" "0.969" "1.042" "1.027" "1.054" "0.992" "0.991" "1.015" "1.063" "700.0" "694.0" "678.0" "729.5" "719.1" "738.0" "694.2" "693.9" "710.5" "744.0" "" "" "" "" "" "" "" "" "" "" "655.9" "574.3" "629.5" "564.0" "613.0" "705.1" "634.3" "616.1" "710.5" "716.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5930476095621651501" "False" "High" "IsMasterProtein" "Q15283" "Ras GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=RASA2 PE=1 SV=3" "0.000" "False" "19.415" "9" "9" "11" "8" "850" "96.6" "7.20" "22.55" "9" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00168, Pf00169, Pf00616, Pf00779" "5922" "ENSG00000155903" "RASA2" "A8K7K1; G3V0F9; hsa:5922; O00695; Q15283; Q15284; Q92594; Q99577; Q9UEQ2" "MAPK signaling pathway; Ebola virus infection in host; Ras signaling; Modulators of TCR signaling and T cell activation" "Regulation of RAS by GAPs" "5" "0" "0.939" "0.997" "1.015" "0.953" "0.993" "0.885" "0.937" "0.917" "0.946" "671.5" "630.6" "669.2" "681.2" "639.9" "666.7" "594.0" "629.3" "615.8" "635.4" "" "" "" "" "" "" "" "" "" "" "629.2" "521.8" "621.2" "526.6" "545.4" "636.9" "542.8" "558.8" "615.8" "611.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1739336077855480502" "False" "High" "IsMasterProtein" "Q9NWY4" "Histone PARylation factor 1 OS=Homo sapiens OX=9606 GN=HPF1 PE=1 SV=2" "0.000" "False" "19.370" "22" "7" "9" "7" "346" "39.4" "6.80" "31.36" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10228" "54969" "ENSG00000056050" "HPF1" "hsa:54969; Q9NWY4" "" "" "0" "0" "1.003" "1.044" "1.111" "1.099" "1.023" "1.036" "1.033" "1.058" "1.069" "653.6" "655.8" "682.0" "726.2" "718.5" "668.7" "677.3" "674.8" "691.5" "698.5" "" "" "" "" "" "" "" "" "" "" "612.4" "542.6" "633.2" "561.4" "612.4" "638.9" "618.8" "599.2" "691.5" "672.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7481599324901596636" "False" "High" "IsMasterProtein" "O75391" "Sperm-associated antigen 7 OS=Homo sapiens OX=9606 GN=SPAG7 PE=1 SV=2" "0.000" "False" "19.339" "32" "6" "6" "6" "227" "26.0" "7.91" "20.90" "6" "" "nucleus" "nucleic acid binding activity" "Pf01424" "9552" "ENSG00000091640" "SPAG7" "hsa:9552; O75391; Q96EU5" "" "" "0" "0" "0.988" "0.930" "1.002" "1.059" "1.002" "0.980" "1.019" "0.947" "0.976" "638.5" "630.8" "593.7" "639.6" "676.0" "639.7" "625.6" "650.4" "604.8" "623.4" "" "" "" "" "" "" "" "" "" "" "598.3" "522.0" "551.1" "494.4" "576.2" "611.2" "571.6" "577.5" "604.8" "600.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088218542987526353" "False" "High" "IsMasterProtein" "P49005" "DNA polymerase delta subunit 2 OS=Homo sapiens OX=9606 GN=POLD2 PE=1 SV=1" "0.000" "False" "19.336" "15" "6" "8" "6" "469" "51.3" "5.58" "32.59" "6" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity" "Pf04042, Pf18018" "5425" "ENSG00000106628" "POLD2" "A4D2J4; B2R5S4; hsa:5425; P49005" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Polymerase switching on the C-strand of the telomere; Polymerase switching" "25" "0" "0.971" "0.981" "0.998" "0.938" "1.008" "0.923" "0.935" "0.952" "1.001" "1534.3" "1489.3" "1505.5" "1531.2" "1439.4" "1546.4" "1416.6" "1433.9" "1460.2" "1535.5" "" "" "" "" "" "" "" "" "" "" "1437.6" "1232.4" "1397.6" "1183.7" "1226.9" "1477.5" "1294.4" "1273.1" "1460.2" "1478.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5453029631849906368" "False" "High" "IsMasterProtein" "Q9NRN7" "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase OS=Homo sapiens OX=9606 GN=AASDHPPT PE=1 SV=2" "0.000" "False" "19.334" "20" "7" "7" "7" "309" "35.8" "6.80" "22.84" "7" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf01648" "60496" "ENSG00000149313" "AASDHPPT" "B2R6D1; B4DDW7; hsa:60496; Q9C068; Q9NRN7; Q9P0Q3; Q9UG80; Q9Y389" "" "Vitamin B5 (pantothenate) metabolism" "1" "0" "0.921" "0.932" "0.897" "0.909" "0.905" "0.907" "0.904" "0.880" "0.875" "1523.6" "1403.1" "1419.9" "1366.0" "1384.6" "1379.7" "1381.5" "1377.3" "1340.7" "1333.2" "" "" "" "" "" "" "" "" "" "" "1427.7" "1161.0" "1318.2" "1056.0" "1180.2" "1318.1" "1262.3" "1222.9" "1340.7" "1283.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7576893625228470779" "False" "High" "IsMasterProtein" "Q9H410" "Kinetochore-associated protein DSN1 homolog OS=Homo sapiens OX=9606 GN=DSN1 PE=1 SV=2" "0.000" "False" "19.294" "17" "7" "10" "7" "356" "40.0" "7.05" "30.54" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08202" "79980" "ENSG00000149636" "DSN1" "B4DWT2; E1P5U9; hsa:79980; Q5JW55; Q5JW56; Q9H410; Q9H8P4" "" "Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "1.034" "1.017" "1.090" "1.046" "1.121" "1.025" "1.006" "1.036" "1.085" "1074.9" "1111.7" "1093.6" "1171.4" "1124.3" "1205.2" "1101.7" "1080.9" "1113.4" "1166.7" "" "" "" "" "" "" "" "" "" "" "1007.2" "919.9" "1015.3" "905.5" "958.3" "1151.5" "1006.7" "959.8" "1113.4" "1123.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8297311667808919408" "False" "High" "IsMasterProtein" "Q14651" "Plastin-1 OS=Homo sapiens OX=9606 GN=PLS1 PE=1 SV=2" "0.000" "False" "19.277" "7" "5" "9" "2" "629" "70.2" "5.41" "30.85" "5" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00036, Pf00307, Pf13405" "5357" "ENSG00000120756" "PLS1" "A8K2Q1; D3DNG3; hsa:5357; Q14651; Q8NEG6" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2935309689569447405" "False" "High" "IsMasterProtein" "Q9BYD6" "Large ribosomal subunit protein uL1m OS=Homo sapiens OX=9606 GN=MRPL1 PE=1 SV=2" "0.000" "False" "19.265" "21" "7" "12" "7" "325" "36.9" "8.78" "33.53" "7" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00687" "65008" "ENSG00000169288" "MRPL1" "A6NG03; hsa:65008; Q4W5B8; Q6IAG4; Q96BW3; Q9BYD6; Q9H793; Q9NRL5" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.967" "1.044" "0.980" "1.037" "1.114" "1.046" "1.096" "1.078" "1.083" "1288.5" "1246.5" "1345.8" "1262.8" "1336.3" "1435.1" "1348.1" "1412.5" "1388.6" "1395.7" "" "" "" "" "" "" "" "" "" "" "1207.4" "1031.5" "1249.4" "976.2" "1139.1" "1371.1" "1231.8" "1254.2" "1388.6" "1343.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9195295084740601325" "False" "High" "IsMasterProtein" "Q00577" "Transcriptional activator protein Pur-alpha OS=Homo sapiens OX=9606 GN=PURA PE=1 SV=2" "0.000" "False" "19.260" "26" "6" "7" "6" "322" "34.9" "6.44" "29.24" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04845" "5813" "ENSG00000185129" "PURA" "hsa:5813; Q00577" "Exercise-induced circadian regulation" "" "1" "0" "0.982" "1.049" "1.011" "0.973" "1.007" "0.939" "1.008" "1.021" "0.974" "914.6" "898.0" "959.8" "924.2" "890.0" "920.6" "859.2" "921.7" "933.6" "891.1" "" "" "" "" "" "" "" "" "" "" "857.0" "743.0" "891.0" "714.5" "758.6" "879.5" "785.1" "818.4" "933.6" "858.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8682712823667695648" "False" "High" "IsMasterProtein" "Q7Z2E3" "Aprataxin OS=Homo sapiens OX=9606 GN=APTX PE=1 SV=2" "0.000" "False" "19.248" "17" "7" "7" "7" "356" "40.7" "9.17" "19.38" "7" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11969, Pf16278, Pf17913" "54840" "ENSG00000137074" "APTX" "A8MTN4; D3DRK9; D3DRL0; hsa:54840; Q0P662; Q5T781; Q5T782; Q5T784; Q6JV81; Q6JV82; Q6JV85; Q7Z2E3; Q7Z2F3; Q7Z336; Q7Z5R5; Q7Z6V7; Q7Z6V8; Q9NXM5" "" "" "0" "0" "1.056" "1.042" "1.097" "1.106" "1.208" "1.087" "1.120" "1.146" "1.115" "581.8" "614.5" "606.0" "638.2" "643.4" "702.7" "632.3" "651.9" "667.0" "648.5" "" "" "" "" "" "" "" "" "" "" "545.1" "508.5" "562.6" "493.3" "548.5" "671.4" "577.8" "578.8" "667.0" "624.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4344816618369671433" "False" "High" "IsMasterProtein" "Q16537" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform OS=Homo sapiens OX=9606 GN=PPP2R5E PE=1 SV=1" "0.000" "False" "19.242" "13" "6" "7" "5" "467" "54.7" "6.95" "24.83" "6" "signal transduction" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01603" "5529" "ENSG00000154001" "PPP2R5E" "A4FU37; B7ZAW5; B7ZKK8; B7ZKK9; hsa:5529; J3KQN6; Q16537; Q52LW4" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; DNA damage response (only ATM dependent)" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Negative regulation of MAPK pathway; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Platelet sensitization by LDL; CTLA4 inhibitory signaling" "28" "0" "0.941" "1.111" "1.215" "1.150" "1.227" "1.127" "1.132" "1.098" "1.149" "166.5" "156.7" "185.0" "202.2" "191.5" "204.3" "187.6" "188.5" "182.8" "191.3" "" "" "" "" "" "" "" "" "" "" "156.0" "129.7" "171.8" "156.3" "163.2" "195.2" "171.4" "167.3" "182.8" "184.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6755202633810832906" "False" "High" "IsMasterProtein" "Q9C0I1" "Myotubularin-related protein 12 OS=Homo sapiens OX=9606 GN=MTMR12 PE=1 SV=2" "0.000" "False" "19.239" "11" "7" "9" "7" "747" "86.1" "6.62" "23.24" "7" "" "cytosol;cytoskeleton;ER/Golgi;other cell component" "" "Pf06602, Pf12578" "54545" "ENSG00000150712" "MTMR12" "hsa:54545; Q69YJ4; Q6PFW3; Q96QU2; Q9C0I1; Q9NX27" "" "Synthesis of PIPs at the early endosome membrane" "1" "0" "1.062" "0.969" "1.136" "1.023" "1.020" "1.013" "0.969" "1.020" "1.021" "313.0" "332.5" "303.4" "355.5" "320.2" "319.3" "317.0" "303.3" "319.4" "319.7" "" "" "" "" "" "" "" "" "" "" "293.3" "275.2" "281.6" "274.8" "273.0" "305.1" "289.7" "269.3" "319.4" "307.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3080210265663367666" "False" "High" "IsMasterProtein" "Q8IY37" "Probable ATP-dependent RNA helicase DHX37 OS=Homo sapiens OX=9606 GN=DHX37 PE=1 SV=1" "0.000" "False" "19.238" "7" "6" "6" "6" "1157" "129.5" "8.10" "18.64" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "57647" "ENSG00000150990" "DHX37" "hsa:57647; Q8IY37; Q9BUI7; Q9P211" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.980" "0.980" "1.090" "1.070" "1.010" "1.049" "1.023" "1.034" "0.962" "507.9" "498.0" "498.0" "553.5" "543.4" "513.2" "533.1" "519.7" "525.0" "488.6" "" "" "" "" "" "" "" "" "" "" "475.9" "412.1" "462.3" "427.9" "463.2" "490.4" "487.1" "461.4" "525.0" "470.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8718116979404921777" "False" "High" "IsMasterProtein" "P51116" "RNA-binding protein FXR2 OS=Homo sapiens OX=9606 GN=FXR2 PE=1 SV=2" "0.000" "False" "19.236" "11" "7" "9" "4" "673" "74.2" "6.23" "28.06" "7" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16096, Pf17904, Pf18336" "9513" "ENSG00000129245" "FXR2" "B2R9M2; D3DTQ1; hsa:9513; P51116; Q86V09; Q8WUM2" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.958" "0.972" "1.103" "1.173" "1.066" "1.254" "1.172" "1.161" "1.061" "250.3" "239.9" "243.2" "276.1" "293.6" "266.7" "314.0" "293.4" "290.6" "265.6" "" "" "" "" "" "" "" "" "" "" "234.5" "198.5" "225.8" "213.5" "250.2" "254.8" "286.9" "260.5" "290.6" "255.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8551300482488071361" "False" "High" "IsMasterProtein" "P78332" "RNA-binding protein 6 OS=Homo sapiens OX=9606 GN=RBM6 PE=1 SV=5" "0.000" "False" "19.195" "6" "8" "10" "6" "1123" "128.6" "6.32" "21.44" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf01585, Pf17780" "10180" "ENSG00000004534" "RBM6" "B4E0G6; hsa:10180; O60549; O75524; P78332; Q86SS3" "" "" "0" "2" "1.106" "1.032" "1.137" "1.125" "1.051" "1.224" "1.188" "1.139" "1.109" "705.8" "780.2" "728.7" "802.3" "794.3" "742.0" "863.6" "838.3" "803.8" "782.9" "" "" "" "" "" "" "" "" "" "" "661.3" "645.6" "676.5" "620.3" "677.0" "708.9" "789.1" "744.3" "803.8" "753.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2510158146736873084" "False" "High" "IsMasterProtein" "P29084" "Transcription initiation factor IIE subunit beta OS=Homo sapiens OX=9606 GN=GTF2E2 PE=1 SV=1" "0.000" "False" "19.194" "20" "7" "8" "7" "291" "33.0" "9.66" "18.76" "7" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf02186, Pf18121" "2961" "ENSG00000197265" "GTF2E2" "D3DSV2; P29084; Q9H2B9" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "10" "0" "0.933" "1.014" "0.931" "1.000" "1.030" "0.911" "0.973" "1.018" "1.054" "1026.0" "957.3" "1040.2" "955.2" "1025.9" "1057.1" "935.1" "998.7" "1044.9" "1081.6" "" "" "" "" "" "" "" "" "" "" "961.3" "792.1" "965.7" "738.4" "874.5" "1010.0" "854.4" "886.7" "1044.9" "1041.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "934468542703033965" "False" "High" "IsMasterProtein" "Q15477" "Superkiller complex protein 2 OS=Homo sapiens OX=9606 GN=SKIC2 PE=1 SV=3" "0.000" "False" "19.190" "6" "8" "8" "8" "1246" "137.7" "6.06" "15.11" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08148, Pf13234, Pf17911, Pf21408" "6499" "ENSG00000204351; ENSG00000206353; ENSG00000223493; ENSG00000225737; ENSG00000228896; ENSG00000232616" "SKIC2" "hsa:6499; O15005; Q12902; Q15476; Q15477; Q5ST66" "" "Association of TriC/CCT with target proteins during biosynthesis; mRNA decay by 3' to 5' exoribonuclease" "2" "0" "0.974" "1.007" "1.069" "1.013" "0.994" "1.017" "1.002" "1.107" "1.090" "468.6" "456.4" "471.7" "501.2" "474.5" "465.7" "476.5" "469.7" "518.6" "510.9" "" "" "" "" "" "" "" "" "" "" "439.1" "377.7" "438.0" "387.4" "404.4" "444.9" "435.4" "417.0" "518.6" "491.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2503112779916804665" "False" "High" "IsMasterProtein" "Q8WV28" "B-cell linker protein OS=Homo sapiens OX=9606 GN=BLNK PE=1 SV=2" "0.000" "False" "19.189" "16" "9" "12" "9" "456" "50.4" "8.16" "32.68" "9" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017" "29760" "ENSG00000095585" "BLNK" "hsa:29760; O75498; O75499; Q2MD49; Q8WV28" "B cell receptor signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Regulation of signaling by CBL" "5" "0" "0.970" "0.970" "0.995" "1.035" "0.994" "0.978" "0.960" "0.937" "0.993" "1015.4" "984.4" "984.9" "1010.1" "1051.1" "1009.2" "992.7" "975.1" "951.9" "1008.3" "" "" "" "" "" "" "" "" "" "" "951.4" "814.6" "914.3" "780.8" "896.0" "964.2" "907.1" "865.8" "951.9" "970.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7727744455345483682" "False" "High" "IsMasterProtein" "Q13868" "Exosome complex component RRP4 OS=Homo sapiens OX=9606 GN=EXOSC2 PE=1 SV=2" "0.000" "False" "19.181" "23" "6" "7" "6" "293" "32.8" "7.50" "25.35" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf14382, Pf15985, Pf21266" "23404" "ENSG00000130713" "EXOSC2" "A3KFL3; A3KFL4; B4DKK6; hsa:23404; Q13868; Q9NUY4" "Ciliary landscape" "ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Major pathway of rRNA processing in the nucleolus and cytosol; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "7" "0" "1.002" "1.040" "1.028" "0.999" "1.036" "1.024" "1.015" "1.007" "1.016" "1534.8" "1538.7" "1595.7" "1578.2" "1533.4" "1590.6" "1570.9" "1558.0" "1546.1" "1558.8" "" "" "" "" "" "" "" "" "" "" "1438.1" "1273.2" "1481.4" "1220.0" "1307.0" "1519.7" "1435.4" "1383.4" "1546.1" "1500.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "340121106600756603" "False" "High" "IsMasterProtein" "Q9UPY3" "Endoribonuclease Dicer OS=Homo sapiens OX=9606 GN=DICER1 PE=1 SV=3" "0.000" "False" "19.166" "4" "8" "8" "8" "1922" "218.5" "5.68" "20.35" "8" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00636, Pf02170, Pf03368, Pf20930, Pf20931, Pf20932" "23405" "ENSG00000100697" "DICER1" "A7E2D3; B3KRG4; E0AD28; hsa:23405; O95943; Q9UPY3; Q9UQ02" "miRNA biogenesis; exRNA mechanism of action and biogenesis; Hypoxia-mediated EMT and stemness; mRNA processing; Fragile X syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "M-decay: degradation of maternal mRNAs by maternally stored factors; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis; tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis" "11" "0" "1.007" "0.947" "1.004" "0.997" "0.973" "0.967" "0.997" "0.929" "0.985" "886.5" "892.4" "839.6" "889.9" "884.1" "862.7" "857.6" "883.7" "823.6" "872.7" "" "" "" "" "" "" "" "" "" "" "830.6" "738.5" "779.5" "687.9" "753.6" "824.2" "783.6" "784.7" "823.6" "840.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3983028009750613022" "False" "High" "IsMasterProtein" "Q8N122" "Regulatory-associated protein of mTOR OS=Homo sapiens OX=9606 GN=RPTOR PE=1 SV=1" "0.000" "False" "19.144" "6" "7" "8" "7" "1335" "148.9" "6.89" "23.73" "7" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf02985, Pf14538" "57521" "ENSG00000141564" "RPTOR" "B2RN36; C6KEF2; F5H7J5; hsa:57521; Q8N122; Q8N4V9; Q8TB32; Q9P2P3" "AMP-activated protein kinase signaling; Target of rapamycin signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; CAMKK2 pathway; Autophagy; p53 transcriptional gene network; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; JAK-STAT signaling in the regulation of beta cells; ADHD and autism (ASD) linked metabolic pathways and SNP; Interferon type I signaling pathways" "Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; HSF1-dependent transactivation" "34" "0" "1.026" "1.058" "1.163" "1.081" "1.053" "1.090" "1.053" "1.025" "1.079" "591.0" "606.6" "625.0" "687.6" "638.7" "622.4" "644.5" "622.2" "605.5" "637.9" "" "" "" "" "" "" "" "" "" "" "553.8" "501.9" "580.3" "531.6" "544.4" "594.6" "588.9" "552.4" "605.5" "614.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3735327687387277491" "False" "High" "IsMasterProtein" "Q16254" "Transcription factor E2F4 OS=Homo sapiens OX=9606 GN=E2F4 PE=1 SV=2" "0.000" "False" "19.143" "16" "7" "8" "5" "413" "43.9" "4.75" "18.56" "7" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02319, Pf16421" "1874" "ENSG00000205250" "E2F4" "A6NGR8; B5BU56; hsa:1874; Q12991; Q15328; Q16254" "Cell cycle; Adipogenesis; TGF-beta signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; Alstrom syndrome" "G1/S-Specific Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Cyclin D associated events in G1; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "14" "0" "1.080" "0.982" "1.110" "1.064" "1.125" "1.028" "1.007" "0.987" "1.083" "373.9" "403.9" "367.3" "415.1" "397.7" "420.7" "384.4" "376.4" "369.1" "405.2" "" "" "" "" "" "" "" "" "" "" "350.4" "334.2" "341.0" "320.9" "339.0" "402.0" "351.2" "334.2" "369.1" "390.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8677465183251509063" "False" "High" "IsMasterProtein" "Q9NX55" "Huntingtin-interacting protein K OS=Homo sapiens OX=9606 GN=HYPK PE=1 SV=3" "0.000" "False" "19.132" "54" "5" "7" "5" "121" "13.6" "4.82" "23.25" "5" "protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf19026" "25764" "ENSG00000242028" "HYPK" "C9JKJ0; hsa:25764; O75408; Q8WUW8; Q9NX55; Q9P024" "" "" "0" "0" "1.174" "0.956" "1.349" "1.115" "1.081" "1.199" "0.960" "1.071" "1.225" "272.1" "319.5" "260.1" "366.9" "303.5" "294.2" "326.3" "261.1" "291.4" "333.3" "" "" "" "" "" "" "" "" "" "" "255.0" "264.3" "241.5" "283.7" "258.7" "281.0" "298.2" "231.8" "291.4" "321.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4101448346661809879" "False" "High" "IsMasterProtein" "Q15819" "Ubiquitin-conjugating enzyme E2 variant 2 OS=Homo sapiens OX=9606 GN=UBE2V2 PE=1 SV=4" "0.000" "False" "19.125" "58" "8" "14" "3" "145" "16.4" "8.09" "38.51" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf00179" "7336" "ENSG00000169139" "UBE2V2" "hsa:7336; Q15819" "" "Antigen processing: Ubiquitination & Proteasome degradation; E3 ubiquitin ligases ubiquitinate target proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Formation of Incision Complex in GG-NER" "7" "3" "1.077" "1.066" "0.967" "1.042" "1.032" "0.939" "1.048" "1.084" "1.023" "1411.0" "1519.3" "1503.5" "1364.1" "1470.0" "1455.6" "1324.3" "1478.4" "1529.2" "1442.8" "" "" "" "" "" "" "" "" "" "" "1322.1" "1257.2" "1395.9" "1054.5" "1253.0" "1390.7" "1210.0" "1312.7" "1529.2" "1389.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1348020526010624498" "False" "High" "IsMasterProtein" "Q13469" "Nuclear factor of activated T-cells, cytoplasmic 2 OS=Homo sapiens OX=9606 GN=NFATC2 PE=1 SV=2" "0.000" "False" "19.101" "7" "6" "8" "5" "925" "100.1" "7.28" "22.16" "6" "RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "4773" "ENSG00000101096" "NFATC2" "B5B2N8; B5B2N9; B5B2P0; B5B2P2; B5B2P3; hsa:4773; Q13468; Q13469; Q5TFW7; Q5TFW8; Q9NPX6; Q9NQH3; Q9UJR2" "Heart development; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Hematopoietic stem cell differentiation; Vitamin D receptor pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Wnt signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Wnt signaling; Cancer immunotherapy by PD-1 blockade; Hepatitis B infection; CAMKK2 pathway; 16p11.2 distal deletion syndrome; Calcium mediated T-cell apoptosis involved in inclusion body myositis; T-cell receptor signaling pathway" "FCERI mediated Ca+2 mobilization; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)" "21" "1" "0.972" "1.065" "1.049" "1.054" "1.028" "0.954" "0.967" "0.981" "1.009" "975.6" "948.6" "1038.5" "1023.7" "1028.7" "1002.8" "930.8" "943.5" "957.1" "984.8" "" "" "" "" "" "" "" "" "" "" "914.1" "784.9" "964.1" "791.3" "876.8" "958.0" "850.5" "837.7" "957.1" "948.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8329541297808121166" "False" "High" "IsMasterProtein" "P49848" "Transcription initiation factor TFIID subunit 6 OS=Homo sapiens OX=9606 GN=TAF6 PE=1 SV=1" "0.000" "False" "19.093" "9" "6" "6" "6" "677" "72.6" "8.60" "15.48" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf02969, Pf07571" "6878" "ENSG00000106290" "TAF6" "A4D2B2; A4D2B3; B4DT11; D6W5U2; hsa:6878; P49848; Q6AI29" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "11" "0" "0.978" "0.996" "0.998" "1.013" "1.006" "1.003" "1.053" "1.030" "1.031" "919.4" "899.6" "916.0" "917.1" "931.7" "924.6" "922.1" "967.9" "946.9" "948.0" "" "" "" "" "" "" "" "" "" "" "861.5" "744.4" "850.4" "709.0" "794.1" "883.4" "842.6" "859.4" "946.9" "912.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8791134701989231462" "False" "High" "IsMasterProtein" "Q9UQ13" "Leucine-rich repeat protein SHOC-2 OS=Homo sapiens OX=9606 GN=SHOC2 PE=1 SV=2" "0.000" "False" "19.083" "12" "7" "9" "7" "582" "64.8" "8.46" "23.65" "7" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13855" "8036" "ENSG00000108061" "SHOC2" "A8K9W8; B3KR23; hsa:8036; O76063; Q5VZS8; Q5VZS9; Q9UQ13" "Ras signaling; 22q11.2 copy number variation syndrome; Autophagy in pancreatic ductal adenocarcinoma" "RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling" "6" "0" "0.972" "1.031" "0.943" "1.062" "1.019" "0.925" "0.988" "0.981" "1.006" "370.2" "360.0" "381.6" "349.0" "393.3" "377.1" "342.6" "365.9" "363.1" "372.2" "" "" "" "" "" "" "" "" "" "" "346.9" "297.9" "354.3" "269.8" "335.2" "360.3" "313.1" "324.9" "363.1" "358.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "841386405994122390" "False" "High" "IsMasterProtein" "Q92785" "Zinc finger protein ubi-d4 OS=Homo sapiens OX=9606 GN=DPF2 PE=1 SV=2" "0.000" "False" "19.083" "18" "6" "6" "6" "391" "44.1" "6.33" "22.05" "6" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00628, Pf14051" "5977" "ENSG00000133884" "DPF2" "A8K7C9; B4DT58; hsa:5977; Q92785" "Tumor suppressor activity of SMARCB1" "" "1" "0" "0.980" "1.083" "0.938" "1.034" "1.058" "0.930" "1.078" "1.047" "1.061" "518.3" "507.7" "561.0" "485.9" "536.0" "548.4" "482.0" "558.6" "542.7" "549.8" "" "" "" "" "" "" "" "" "" "" "485.6" "420.1" "520.8" "375.6" "456.9" "524.0" "440.4" "496.0" "542.7" "529.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "59184659773015562" "False" "High" "IsMasterProtein" "Q969H8" "Myeloid-derived growth factor OS=Homo sapiens OX=9606 GN=MYDGF PE=1 SV=1" "0.000" "False" "19.079" "27" "6" "8" "6" "173" "18.8" "6.68" "24.59" "6" "developmental processes;other biological processes" "non-structural extracellular;ER/Golgi" "" "Pf10572" "56005" "ENSG00000074842" "MYDGF" "D6W628; hsa:56005; O75256; O75272; Q969H8; Q9BTK7; Q9NP69" "" "XBP1(S) activates chaperone genes" "1" "0" "0.958" "0.968" "0.958" "0.910" "0.964" "0.908" "0.920" "0.940" "0.932" "1298.9" "1244.3" "1257.2" "1245.0" "1181.8" "1252.6" "1179.0" "1195.0" "1220.5" "1211.0" "" "" "" "" "" "" "" "" "" "" "1217.1" "1029.7" "1167.1" "962.5" "1007.4" "1196.8" "1077.3" "1061.1" "1220.5" "1166.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8882666347281850930" "False" "High" "IsMasterProtein" "P48739" "Phosphatidylinositol transfer protein beta isoform OS=Homo sapiens OX=9606 GN=PITPNB PE=1 SV=2" "0.000" "False" "19.074" "26" "7" "11" "6" "271" "31.5" "6.87" "34.10" "7" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf02121" "23760" "ENSG00000180957" "PITPNB" "B3KYB8; B7Z7Q0; hsa:23760; P48739; Q8N5W1" "" "PI and PC transport between ER and Golgi membranes" "1" "0" "0.916" "0.927" "0.916" "0.908" "0.909" "0.938" "0.933" "0.952" "0.950" "1019.1" "933.3" "944.8" "933.6" "924.9" "926.6" "955.8" "950.6" "969.7" "968.4" "" "" "" "" "" "" "" "" "" "" "954.9" "772.3" "877.2" "721.7" "788.4" "885.3" "873.3" "844.1" "969.7" "932.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "647250025127974157" "False" "High" "IsMasterProtein" "Q15004" "PCNA-associated factor OS=Homo sapiens OX=9606 GN=PCLAF PE=1 SV=1" "0.000" "False" "19.071" "56" "6" "10" "6" "111" "12.0" "9.83" "36.09" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15715" "9768" "ENSG00000166803" "PCLAF" "A6NNU5; A8K3Y3; G9G694; G9G696; hsa:9768; Q15004" "" "Termination of translesion DNA synthesis" "1" "0" "1.006" "1.013" "0.946" "0.983" "0.961" "0.890" "0.912" "0.869" "0.982" "1566.4" "1575.6" "1586.2" "1481.7" "1540.5" "1505.1" "1393.9" "1428.6" "1361.9" "1537.7" "" "" "" "" "" "" "" "" "" "" "1467.7" "1303.8" "1472.6" "1145.4" "1313.1" "1438.0" "1273.7" "1268.5" "1361.9" "1480.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8124726233717471609" "False" "High" "IsMasterProtein" "P50750" "Cyclin-dependent kinase 9 OS=Homo sapiens OX=9606 GN=CDK9 PE=1 SV=3" "0.000" "False" "19.063" "18" "7" "11" "5" "372" "42.8" "8.79" "28.39" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "1025" "ENSG00000136807" "CDK9" "hsa:1025; P50750; Q5JU24; Q5JU25; Q5U006; Q96TF1" "MicroRNAs in cardiomyocyte hypertrophy; IL-9 signaling pathway; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins" "20" "0" "0.985" "1.073" "1.126" "1.076" "1.015" "1.110" "1.084" "1.046" "1.052" "805.4" "793.7" "864.4" "907.3" "867.0" "817.1" "894.2" "872.7" "842.2" "847.2" "" "" "" "" "" "" "" "" "" "" "754.7" "656.8" "802.4" "701.4" "739.0" "780.7" "817.1" "774.9" "842.2" "815.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5664998384620828706" "False" "High" "IsMasterProtein" "Q13895" "Bystin OS=Homo sapiens OX=9606 GN=BYSL PE=1 SV=3" "0.000" "False" "19.056" "15" "7" "7" "7" "437" "49.6" "8.12" "21.66" "7" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05291" "705" "ENSG00000112578" "BYSL" "hsa:705; Q13895; Q6P5W4; Q86W44; Q96IP8" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.154" "1.118" "1.205" "1.214" "1.189" "1.334" "1.374" "1.260" "1.158" "438.3" "505.8" "489.9" "528.3" "532.2" "521.1" "584.7" "602.4" "552.4" "507.5" "" "" "" "" "" "" "" "" "" "" "410.7" "418.5" "454.8" "408.4" "453.6" "497.9" "534.3" "534.9" "552.4" "488.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8250639024737902778" "False" "High" "IsMasterProtein" "O14727" "Apoptotic protease-activating factor 1 OS=Homo sapiens OX=9606 GN=APAF1 PE=1 SV=2" "0.000" "False" "19.054" "6" "8" "8" "8" "1248" "141.7" "6.40" "19.17" "8" "stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf00619, Pf00931, Pf17908, Pf21296" "317" "ENSG00000120868" "APAF1" "B2RMX8; hsa:317; O14727; O43297; Q7Z438; Q9BXZ6; Q9UBZ5; Q9UGN8; Q9UGN9; Q9UGP0; Q9UJ58; Q9UJ59; Q9UJ60; Q9UJ61; Q9UJ62; Q9UJ63; Q9UJ64; Q9UJ65; Q9UJ66; Q9UJ67; Q9UNC9" "miRNA regulation of DNA damage response; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Parkinson's disease pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; p53 transcriptional gene network; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response" "Neutrophil degranulation; Transcriptional Regulation by E2F6; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of the apoptosome activity" "28" "0" "1.117" "1.001" "1.098" "1.094" "1.092" "0.988" "0.926" "0.981" "1.046" "737.8" "824.1" "738.5" "810.5" "806.9" "805.6" "728.6" "683.0" "723.5" "772.1" "" "" "" "" "" "" "" "" "" "" "691.3" "681.9" "685.6" "626.5" "687.8" "769.6" "665.7" "606.4" "723.5" "743.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2854050072506968056" "False" "High" "IsMasterProtein" "P29372" "DNA-3-methyladenine glycosylase OS=Homo sapiens OX=9606 GN=MPG PE=1 SV=3" "0.000" "False" "19.039" "24" "6" "7" "6" "298" "32.8" "9.57" "21.94" "6" "DNA metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf02245" "4350" "ENSG00000103152" "MPG" "G5E9E2; hsa:4350; P29372; Q13770; Q15275; Q15961; Q5J9I4; Q96BZ6; Q96S33; Q9NNX5" "Base excision repair; DNA repair pathways, full network" "Recognition and association of DNA glycosylase with site containing an affected purine; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1" "5" "0" "0.972" "0.973" "1.082" "1.059" "0.917" "1.055" "1.013" "0.949" "0.982" "481.7" "468.1" "468.5" "521.3" "510.2" "441.9" "508.3" "487.9" "457.1" "473.1" "" "" "" "" "" "" "" "" "" "" "451.3" "387.3" "434.9" "403.0" "434.9" "422.2" "464.5" "433.2" "457.1" "455.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5997632050867013674" "False" "High" "IsMasterProtein" "Q9UGR2" "Zinc finger CCCH domain-containing protein 7B OS=Homo sapiens OX=9606 GN=ZC3H7B PE=1 SV=2" "0.000" "False" "19.026" "8" "8" "12" "8" "977" "109.8" "7.25" "31.25" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00642, Pf13181" "23264" "ENSG00000100403" "ZC3H7B" "A7YY88; B2RCA4; hsa:23264; Q5TFX9; Q8TBT9; Q9H8B6; Q9UGQ9; Q9UGR0; Q9UGR1; Q9UGR2; Q9UK03; Q9UPW9" "" "" "0" "0" "0.876" "0.929" "0.965" "0.976" "0.940" "0.988" "0.908" "0.869" "0.974" "696.5" "610.2" "647.1" "671.9" "680.1" "654.9" "688.2" "632.5" "605.3" "678.7" "" "" "" "" "" "" "" "" "" "" "652.6" "504.9" "600.7" "519.4" "579.7" "625.7" "628.8" "561.6" "605.3" "653.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7232907791819213920" "False" "High" "IsMasterProtein" "Q9Y5Z4" "Heme-binding protein 2 OS=Homo sapiens OX=9606 GN=HEBP2 PE=1 SV=1" "0.000" "False" "19.010" "31" "6" "8" "6" "205" "22.9" "4.63" "25.82" "6" "" "non-structural extracellular;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04832" "23593" "ENSG00000051620" "HEBP2" "hsa:23593; Q96P57; Q9Y5Z4" "" "Neutrophil degranulation" "1" "0" "1.088" "1.054" "0.998" "1.062" "1.099" "1.020" "1.038" "1.046" "1.043" "988.6" "1076.0" "1041.7" "986.4" "1049.8" "1086.8" "1008.7" "1025.8" "1034.1" "1031.4" "" "" "" "" "" "" "" "" "" "" "926.4" "890.4" "967.1" "762.5" "894.8" "1038.3" "921.7" "910.8" "1034.1" "993.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "353320057128082956" "False" "High" "IsMasterProtein" "Q13242" "Serine/arginine-rich splicing factor 9 OS=Homo sapiens OX=9606 GN=SRSF9 PE=1 SV=1" "0.000" "False" "18.986" "29" "7" "7" "7" "221" "25.5" "8.65" "15.29" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "8683" "ENSG00000111786" "SRSF9" "hsa:8683; Q13242; Q52LD1" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "6" "0" "1.013" "1.076" "0.956" "0.975" "1.027" "0.882" "0.907" "0.997" "1.016" "798.3" "808.7" "859.1" "763.2" "778.3" "819.7" "704.2" "723.7" "795.6" "810.8" "" "" "" "" "" "" "" "" "" "" "748.0" "669.2" "797.6" "590.0" "663.4" "783.2" "643.5" "642.6" "795.6" "780.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2447610796588384838" "False" "High" "IsMasterProtein" "Q96SZ5" "2-aminoethanethiol dioxygenase OS=Homo sapiens OX=9606 GN=ADO PE=1 SV=2" "0.000" "False" "18.974" "24" "7" "9" "7" "270" "29.7" "6.04" "23.95" "7" "stress response" "cytosol" "other molecular function" "Pf07847" "84890" "ENSG00000181915" "ADO" "B1AL29; hsa:84890; Q96SZ5" "" "Degradation of cysteine and homocysteine" "1" "0" "0.984" "1.005" "1.107" "1.036" "1.072" "0.997" "0.977" "0.994" "1.030" "690.0" "679.1" "693.6" "763.5" "715.1" "739.9" "687.6" "674.2" "685.7" "710.7" "" "" "" "" "" "" "" "" "" "" "646.5" "561.9" "643.9" "590.2" "609.6" "706.9" "628.3" "598.6" "685.7" "684.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4793391525152750587" "False" "High" "IsMasterProtein" "P61020" "Ras-related protein Rab-5B OS=Homo sapiens OX=9606 GN=RAB5B PE=1 SV=1" "0.000" "False" "18.947" "20" "4" "6" "1" "215" "23.7" "8.13" "24.45" "4" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5869" "ENSG00000111540" "RAB5B" "A8K982; B4DKD7; hsa:5869; P35239; P35277; P61020; Q6PIK9; Q86TH0; Q8IXL2" "Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Vasopressin-regulated water reabsorption" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; TBC/RABGAPs" "9" "0" "0.918" "0.950" "0.990" "0.988" "0.903" "0.926" "0.903" "0.946" "0.934" "446.4" "409.7" "424.1" "442.1" "440.9" "403.1" "413.2" "403.0" "422.3" "417.0" "" "" "" "" "" "" "" "" "" "" "418.3" "339.0" "393.7" "341.8" "375.8" "385.1" "377.5" "357.8" "422.3" "401.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "385044699666679526" "False" "High" "IsMasterProtein" "P49756" "RNA-binding protein 25 OS=Homo sapiens OX=9606 GN=RBM25 PE=1 SV=3" "0.000" "False" "18.929" "8" "7" "8" "7" "843" "100.1" "6.32" "23.69" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf01480" "58517" "ENSG00000119707" "RBM25" "A0PJL9; B2RNA8; B3KT03; hsa:58517; P49756; Q2TA72; Q5XJ17; Q6P665; Q9H6A1; Q9UEQ5; Q9UIE9" "" "mRNA Splicing - Major Pathway" "1" "0" "0.961" "0.980" "0.903" "0.878" "0.991" "0.941" "0.889" "0.930" "0.931" "2247.1" "2158.6" "2202.6" "2030.1" "1973.1" "2226.9" "2114.6" "1998.8" "2089.0" "2092.4" "" "" "" "" "" "" "" "" "" "" "2105.6" "1786.2" "2044.8" "1569.3" "1681.8" "2127.6" "1932.2" "1774.7" "2089.0" "2014.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5805697236743296122" "False" "High" "IsMasterProtein" "Q96QU8" "Exportin-6 OS=Homo sapiens OX=9606 GN=XPO6 PE=1 SV=1" "0.000" "False" "18.909" "6" "7" "8" "7" "1125" "128.8" "6.35" "23.72" "7" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03810, Pf08389" "23214" "ENSG00000169180" "XPO6" "A1L3W4; D3DWF9; hsa:23214; Q2YDX3; Q53G88; Q68G50; Q76N88; Q96CP8; Q96QU8; Q9BT21" "" "" "0" "0" "0.993" "0.985" "1.057" "1.043" "0.985" "0.977" "0.990" "1.007" "0.991" "746.2" "740.7" "735.3" "789.1" "778.0" "734.7" "729.1" "738.7" "751.5" "739.5" "" "" "" "" "" "" "" "" "" "" "699.2" "612.9" "682.6" "610.0" "663.2" "701.9" "666.2" "655.9" "751.5" "712.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4687575668731336676" "False" "High" "IsMasterProtein" "Q6UX04" "Spliceosome-associated protein CWC27 homolog OS=Homo sapiens OX=9606 GN=CWC27 PE=1 SV=1" "0.000" "False" "18.887" "18" "7" "8" "7" "472" "53.8" "5.80" "18.29" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00160" "10283" "ENSG00000153015" "CWC27" "hsa:10283; O60529; O60530; Q6UX04; Q96EM3" "" "mRNA Splicing - Major Pathway" "1" "0" "0.967" "1.019" "1.020" "1.006" "1.064" "1.034" "1.008" "0.952" "0.995" "351.1" "339.6" "357.7" "358.0" "353.1" "373.5" "362.9" "354.0" "334.2" "349.4" "" "" "" "" "" "" "" "" "" "" "328.9" "281.0" "332.1" "276.8" "301.0" "356.8" "331.6" "314.3" "334.2" "336.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2238479499176412626" "False" "High" "IsMasterProtein" "O60828" "Polyglutamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PQBP1 PE=1 SV=1" "0.000" "False" "18.880" "29" "6" "7" "6" "265" "30.5" "6.33" "27.78" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "10084" "ENSG00000102103; ENSG00000292208" "PQBP1" "C9JQA1; hsa:10084; O60828; Q4VY25; Q4VY26; Q4VY27; Q4VY29; Q4VY30; Q4VY34; Q4VY35; Q4VY36; Q4VY37; Q4VY38; Q9GZP2; Q9GZU4; Q9GZZ4" "" "mRNA Splicing - Major Pathway" "1" "0" "1.118" "1.057" "1.138" "1.057" "1.078" "1.043" "1.123" "1.084" "1.079" "477.8" "534.1" "505.2" "543.9" "505.1" "515.3" "498.5" "536.7" "517.8" "515.6" "" "" "" "" "" "" "" "" "" "" "447.7" "441.9" "469.0" "420.5" "430.5" "492.3" "455.5" "476.6" "517.8" "496.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1584990058854155939" "False" "High" "IsMasterProtein" "Q9NPI6" "mRNA-decapping enzyme 1A OS=Homo sapiens OX=9606 GN=DCP1A PE=1 SV=3" "0.000" "False" "18.876" "14" "6" "6" "6" "582" "63.2" "6.25" "18.30" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf06058, Pf16741" "55802" "ENSG00000272886" "DCP1A" "B4DHN9; hsa:55802; Q9NPI6; U3KQM8" "TGF-beta signaling pathway" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; mRNA decay by 5' to 3' exoribonuclease; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "5" "0" "0.958" "0.935" "0.984" "0.990" "1.013" "0.967" "0.968" "0.885" "1.007" "804.6" "771.0" "752.5" "791.9" "796.2" "815.2" "777.6" "779.1" "711.9" "810.5" "" "" "" "" "" "" "" "" "" "" "753.9" "638.0" "698.6" "612.1" "678.7" "778.9" "710.6" "691.7" "711.9" "780.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5457086219515973345" "False" "High" "IsMasterProtein" "P61086" "Ubiquitin-conjugating enzyme E2 K OS=Homo sapiens OX=9606 GN=UBE2K PE=1 SV=3" "0.000" "False" "18.859" "30" "5" "6" "5" "200" "22.4" "5.44" "23.11" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179, Pf00627" "3093" "ENSG00000078140" "UBE2K" "A6NJC1; A8K5Y9; B2RDF8; C9JGP1; hsa:3093; O54806; P27924; P61086; Q16721; Q9CVV9; Q9Y2D3" "" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Negative regulators of DDX58/IFIH1 signaling" "3" "0" "0.920" "0.963" "0.988" "0.985" "1.027" "0.982" "0.997" "0.985" "0.920" "451.0" "414.8" "434.3" "445.8" "444.3" "463.0" "442.7" "449.5" "444.3" "415.0" "" "" "" "" "" "" "" "" "" "" "422.5" "343.2" "403.2" "344.6" "378.7" "442.4" "404.5" "399.1" "444.3" "399.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "743572851164951841" "False" "High" "IsMasterProtein" "Q13472" "DNA topoisomerase 3-alpha OS=Homo sapiens OX=9606 GN=TOP3A PE=1 SV=1" "0.000" "False" "18.858" "7" "8" "8" "8" "1001" "112.3" "8.34" "22.41" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01131, Pf01396, Pf01751, Pf06839" "7156" "ENSG00000177302; ENSG00000284238" "TOP3A" "A8KA61; B4DK80; D3DXC7; hsa:7156; Q13472; Q13473" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "HDR through Single Strand Annealing (SSA); Processing of DNA double-strand break ends; Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; Impaired BRCA2 binding to RAD51" "16" "0" "1.023" "1.033" "1.099" "1.059" "1.023" "1.092" "1.140" "1.114" "1.099" "1340.8" "1371.4" "1385.7" "1474.0" "1419.8" "1371.2" "1463.7" "1528.1" "1493.3" "1473.3" "" "" "" "" "" "" "" "" "" "" "1256.3" "1134.8" "1286.4" "1139.5" "1210.2" "1310.0" "1337.4" "1356.8" "1493.3" "1418.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6802113826893248650" "False" "High" "IsMasterProtein" "P07108" "Acyl-CoA-binding protein OS=Homo sapiens OX=9606 GN=DBI PE=1 SV=2" "0.000" "False" "18.852" "51" "3" "5" "3" "87" "10.0" "6.57" "20.85" "3" "other metabolic processes;other biological processes" "ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00887" "1622" "ENSG00000155368" "DBI" "B8ZWD2; B8ZWD6; B8ZWD7; hsa:1622; P07108; P08869; Q4VWZ6; Q53SQ7; Q6IB48; Q9UCI8" "Sterol regulatory element-binding proteins (SREBP) signaling; PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Fatty acid transporters" "Mitochondrial Fatty Acid Beta-Oxidation" "6" "0" "1.001" "0.987" "0.912" "0.957" "0.948" "0.917" "0.939" "1.044" "1.006" "1006.6" "1008.0" "993.4" "918.0" "962.9" "954.4" "922.6" "945.1" "1050.4" "1012.7" "" "" "" "" "" "" "" "" "" "" "943.2" "834.1" "922.2" "709.6" "820.7" "911.8" "843.0" "839.1" "1050.4" "975.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3793795971274937654" "False" "High" "IsMasterProtein" "Q96S59" "Ran-binding protein 9 OS=Homo sapiens OX=9606 GN=RANBP9 PE=1 SV=1" "0.000" "False" "18.837" "10" "6" "7" "6" "729" "77.8" "6.79" "23.82" "6" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00622, Pf08513, Pf10607" "10048" "ENSG00000010017" "RANBP9" "A0PJA2; B2R8E1; hsa:10048; O94764; Q6P3T7; Q7LBR2; Q7Z7F9; Q96S59" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Ciliary landscape" "RAF/MAP kinase cascade; L1CAM interactions; MET activates RAS signaling" "5" "0" "1.018" "1.034" "1.066" "0.995" "1.046" "0.984" "1.005" "1.028" "0.990" "646.4" "657.9" "668.5" "689.2" "642.9" "676.2" "636.2" "649.3" "664.4" "640.2" "" "" "" "" "" "" "" "" "" "" "605.6" "544.4" "620.7" "532.8" "548.0" "646.1" "581.3" "576.5" "664.4" "616.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1871609499973025843" "False" "High" "IsMasterProtein" "Q07021" "Complement component 1 Q subcomponent-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=C1QBP PE=1 SV=1" "0.000" "False" "18.836" "21" "4" "12" "4" "282" "31.3" "4.84" "42.70" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;translation activity;nucleic acid binding activity;other molecular function" "Pf02330" "708" "ENSG00000108561" "C1QBP" "hsa:708; Q07021; Q2HXR8; Q9NNY8" "Complement system; Mesodermal commitment pathway; Ebola virus infection in host" "RHOC GTPase cycle; RHOA GTPase cycle; Intrinsic Pathway of Fibrin Clot Formation; Apoptotic factor-mediated response; Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function" "8" "0" "1.114" "1.137" "1.136" "1.188" "1.109" "1.114" "1.109" "1.106" "1.137" "771.8" "859.6" "877.9" "876.5" "917.1" "855.5" "860.0" "855.9" "853.8" "877.2" "" "" "" "" "" "" "" "" "" "" "723.1" "711.3" "815.0" "677.6" "781.7" "817.4" "785.8" "760.0" "853.8" "844.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3970443704612931563" "False" "High" "IsMasterProtein" "P36578" "Large ribosomal subunit protein uL4 OS=Homo sapiens OX=9606 GN=RPL4 PE=1 SV=5" "0.000" "False" "18.825" "14" "6" "8" "6" "427" "47.7" "11.06" "23.25" "6" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00573, Pf14374" "6124" "ENSG00000174444" "RPL4" "A8K502; hsa:6124; P36578; P39029; Q4VBR0; Q969Z9" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.015" "0.988" "1.017" "1.002" "0.972" "1.011" "0.958" "0.926" "0.975" "480.0" "487.1" "474.1" "488.3" "481.0" "466.5" "485.4" "460.0" "444.3" "467.8" "" "" "" "" "" "" "" "" "" "" "449.7" "403.1" "440.1" "377.5" "410.0" "445.7" "443.5" "408.5" "444.3" "450.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1384123657554198198" "False" "High" "IsMasterProtein" "Q8NHQ9" "ATP-dependent RNA helicase DDX55 OS=Homo sapiens OX=9606 GN=DDX55 PE=1 SV=3" "0.000" "False" "18.732" "10" "6" "7" "6" "600" "68.5" "9.25" "22.40" "6" "" "cytosol;nucleus" "other molecular function" "Pf00270, Pf00271, Pf13959" "57696" "ENSG00000111364" "DDX55" "hsa:57696; Q658L6; Q8IYH0; Q8NHQ9; Q9HCH7" "" "" "0" "0" "1.306" "0.954" "1.187" "1.244" "1.188" "1.109" "1.037" "1.171" "1.075" "834.3" "1089.4" "795.9" "990.3" "1038.0" "991.0" "925.5" "865.1" "977.1" "896.7" "" "" "" "" "" "" "" "" "" "" "781.8" "901.5" "738.9" "765.6" "884.8" "946.8" "845.7" "768.2" "977.1" "863.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4429006779143257910" "False" "High" "IsMasterProtein" "Q14320" "Protein FAM50A OS=Homo sapiens OX=9606 GN=FAM50A PE=1 SV=2" "0.000" "False" "18.705" "18" "5" "5" "5" "339" "40.2" "6.83" "19.74" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf04921" "9130" "ENSG00000071859" "FAM50A" "A8KAQ4; B2R997; hsa:9130; Q14320; Q5HY37; Q6PJH5" "" "mRNA Splicing - Major Pathway" "1" "0" "0.970" "1.035" "1.061" "1.099" "1.086" "1.053" "1.033" "1.110" "1.118" "487.8" "473.0" "505.0" "517.7" "536.3" "530.0" "513.8" "503.8" "541.4" "545.5" "" "" "" "" "" "" "" "" "" "" "457.1" "391.4" "468.8" "400.2" "457.2" "506.4" "469.5" "447.3" "541.4" "525.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4144550306187805462" "False" "High" "IsMasterProtein" "Q68E01" "Integrator complex subunit 3 OS=Homo sapiens OX=9606 GN=INTS3 PE=1 SV=1" "0.000" "False" "18.680" "7" "7" "8" "7" "1043" "118.0" "5.80" "31.36" "7" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf10189" "65123" "ENSG00000143624; ENSG00000262826" "INTS3" "A8K1W0; B4DQC8; B4E3U9; D3DV57; hsa:65123; Q4G0E5; Q5VUQ5; Q5VUQ6; Q5VUR0; Q5VUR1; Q68DJ1; Q68E01; Q69YR5; Q6AI57; Q6DKG7; Q6MZQ4; Q6MZZ9; Q8NC46; Q8TB23; Q9H6S9" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "0.992" "0.982" "1.045" "1.016" "0.986" "1.004" "1.001" "1.012" "1.001" "940.6" "933.1" "923.9" "982.9" "955.6" "927.3" "944.2" "942.0" "952.3" "941.1" "" "" "" "" "" "" "" "" "" "" "881.4" "772.2" "857.7" "759.8" "814.6" "885.9" "862.8" "836.4" "952.3" "906.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7415542887713691593" "False" "High" "IsMasterProtein" "Q01469" "Fatty acid-binding protein 5 OS=Homo sapiens OX=9606 GN=FABP5 PE=1 SV=3" "0.000" "False" "18.676" "36" "6" "11" "6" "135" "15.2" "7.01" "41.13" "6" "other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00061" "2171" "ENSG00000164687" "FABP5" "B2R4K0; hsa:2171; Q01469" "PPAR signaling pathway; Fatty acid transporters" "Neutrophil degranulation; Triglyceride catabolism; Signaling by Retinoic Acid" "5" "0" "1.026" "0.982" "0.985" "0.997" "0.908" "0.964" "0.976" "0.908" "0.950" "2716.0" "2785.6" "2666.6" "2676.3" "2708.4" "2466.4" "2617.3" "2651.5" "2465.6" "2579.6" "" "" "" "" "" "" "" "" "" "" "2544.9" "2305.0" "2475.6" "2068.9" "2308.5" "2356.4" "2391.5" "2354.3" "2465.6" "2483.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8640947955125983665" "False" "High" "IsMasterProtein" "Q9Y5A7" "NEDD8 ultimate buster 1 OS=Homo sapiens OX=9606 GN=NUB1 PE=1 SV=2" "0.000" "False" "18.665" "12" "6" "8" "6" "615" "70.5" "5.96" "27.79" "6" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "" "Pf00627, Pf18037" "51667" "ENSG00000013374" "NUB1" "hsa:51667; O95422; Q75MR9; Q8IX22; Q9BXR2; Q9Y5A7" "" "" "0" "0" "0.912" "0.936" "0.971" "0.965" "0.951" "0.913" "0.883" "0.860" "0.919" "360.0" "328.3" "336.9" "349.6" "347.3" "342.3" "328.7" "318.0" "309.6" "330.7" "" "" "" "" "" "" "" "" "" "" "337.3" "271.7" "312.7" "270.3" "296.0" "327.0" "300.3" "282.4" "309.6" "318.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5765890645847651977" "False" "High" "IsMasterProtein" "Q14790" "Caspase-8 OS=Homo sapiens OX=9606 GN=CASP8 PE=1 SV=1" "0.000" "False" "18.652" "16" "7" "10" "7" "479" "55.4" "5.10" "19.70" "7" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00656, Pf01335" "841" "ENSG00000064012" "CASP8" "hsa:841; O14676; Q14790; Q14791; Q14792; Q14793; Q14794; Q14795; Q14796; Q15780; Q15806; Q53TT5; Q8TDI1; Q8TDI2; Q8TDI3; Q8TDI4; Q8TDI5; Q96T22; Q9C0K4; Q9UQ81" "Nucleotide-binding oligomerization domain (NOD) pathway; miRNA regulation of DNA damage response; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft rejection; Parkin-ubiquitin proteasomal system pathway; Nanomaterial induced apoptosis; Nanoparticle triggered regulated necrosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; miRNA regulation of p53 pathway in prostate cancer; Non-small cell lung cancer; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; 16p11.2 proximal deletion syndrome; Complement system in neuronal development and plasticity; CCL18 signaling pathway; Alzheimer's disease; DNA damage response; Toll-like receptor signaling pathway" "TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TRAIL signaling; NOD1/2 Signaling Pathway; Regulation of TNFR1 signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Regulation of NF-kappa B signaling; TLR3-mediated TICAM1-dependent programmed cell death; Caspase-mediated cleavage of cytoskeletal proteins; TNFR1-induced proapoptotic signaling; CLEC7A/inflammasome pathway; Microbial modulation of RIPK1-mediated regulated necrosis; Activation, myristolyation of BID and translocation to mitochondria; FasL/ CD95L signaling; Defective RIPK1-mediated regulated necrosis" "54" "0" "0.970" "1.017" "1.018" "0.993" "1.002" "0.943" "1.003" "0.988" "0.989" "746.0" "723.9" "758.8" "759.8" "741.0" "747.7" "703.1" "748.6" "737.0" "737.9" "" "" "" "" "" "" "" "" "" "" "699.0" "599.0" "704.5" "587.3" "631.6" "714.3" "642.5" "664.7" "737.0" "710.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7307754887580196146" "False" "High" "IsMasterProtein" "Q13287" "N-myc-interactor OS=Homo sapiens OX=9606 GN=NMI PE=1 SV=2" "0.000" "False" "18.633" "20" "7" "9" "7" "307" "35.0" "5.34" "30.84" "7" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf07292, Pf07334" "9111" "ENSG00000123609" "NMI" "B5BU69; hsa:9111; Q13287; Q53TI8; Q8WTW2; Q9BVE5" "IL-2 signaling pathway" "SARS-CoV-1 activates/modulates innate immune responses" "2" "0" "0.908" "0.932" "0.977" "0.946" "0.954" "0.893" "0.923" "0.906" "0.896" "1350.1" "1225.6" "1258.6" "1319.4" "1276.8" "1287.9" "1205.6" "1246.7" "1223.2" "1210.1" "" "" "" "" "" "" "" "" "" "" "1265.0" "1014.1" "1168.5" "1019.9" "1088.3" "1230.5" "1101.6" "1106.9" "1223.2" "1165.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8133937274084103067" "False" "High" "IsMasterProtein" "P28074" "Proteasome subunit beta type-5 OS=Homo sapiens OX=9606 GN=PSMB5 PE=1 SV=3" "0.000" "False" "18.620" "21" "6" "7" "6" "263" "28.5" "6.92" "24.05" "6" "protein metabolism;other metabolic processes;stress response" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00227" "5693" "ENSG00000100804" "PSMB5" "B2R4N9; B4DUM9; D3DS43; E9PAV2; hsa:5693; P28074; Q16242; Q6PEW2; Q7Z3B5; Q86T01; Q9TNN9" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Asymmetric localization of PCP proteins; Degradation of DVL; ER-Phagosome pathway; Regulation of expression of SLITs and ROBOs; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "1.056" "0.971" "1.063" "1.016" "1.074" "0.939" "0.984" "1.056" "1.018" "695.8" "734.7" "675.7" "739.7" "706.6" "747.0" "653.2" "684.6" "734.8" "708.4" "" "" "" "" "" "" "" "" "" "" "652.0" "608.0" "627.3" "571.8" "602.3" "713.7" "596.9" "607.9" "734.8" "682.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "155528844813379728" "False" "High" "IsMasterProtein" "Q68CZ2" "Tensin-3 OS=Homo sapiens OX=9606 GN=TNS3 PE=1 SV=2" "0.000" "False" "18.604" "4" "7" "7" "7" "1445" "155.2" "6.81" "23.49" "7" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00017, Pf08416, Pf10409" "64759" "ENSG00000136205" "TNS3" "B2RNV1; hsa:64759; Q68CZ2; Q6IPQ2; Q8IZW7; Q8NAD0; Q96PE0; Q96S48" "" "MET interacts with TNS proteins" "1" "0" "1.016" "1.032" "0.951" "1.020" "0.979" "1.056" "0.962" "0.950" "1.017" "758.7" "770.8" "782.8" "721.7" "774.1" "742.5" "800.8" "729.9" "720.9" "771.4" "" "" "" "" "" "" "" "" "" "" "710.9" "637.8" "726.7" "557.9" "659.8" "709.4" "731.7" "648.1" "720.9" "742.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5466542288326959120" "False" "High" "IsMasterProtein" "P59998" "Actin-related protein 2/3 complex subunit 4 OS=Homo sapiens OX=9606 GN=ARPC4 PE=1 SV=3" "0.000" "False" "18.600" "32" "6" "11" "6" "168" "19.7" "8.43" "38.81" "6" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf05856" "10093" "ENSG00000241553" "ARPC4" "C9JWM7; E7ETI0; F6TTL5; hsa:10093; O15509; P59998; Q6P0W5; Q96QJ3" "Pathogenic Escherichia coli infection" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "6" "0" "0.946" "0.975" "0.959" "0.946" "0.950" "0.945" "0.921" "0.949" "0.953" "1102.0" "1042.3" "1074.5" "1057.0" "1043.0" "1046.8" "1041.8" "1014.4" "1045.9" "1050.2" "" "" "" "" "" "" "" "" "" "" "1032.6" "862.5" "997.6" "817.1" "889.0" "1000.1" "951.9" "900.7" "1045.9" "1011.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-242437446693964013" "False" "High" "IsMasterProtein" "Q92997" "Segment polarity protein dishevelled homolog DVL-3 OS=Homo sapiens OX=9606 GN=DVL3 PE=1 SV=2" "0.000" "False" "18.593" "8" "6" "9" "2" "716" "78.0" "6.65" "29.96" "6" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00595, Pf00610, Pf00778, Pf02377, Pf12316" "1857" "ENSG00000161202" "DVL3" "B4E3E5; D3DNT0; hsa:1857; O14642; Q13531; Q8N5E9; Q92607; Q92997" "Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Joubert syndrome; Pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)" "WNT mediated activation of DVL; Degradation of DVL; RHO GTPases Activate Formins; PCP/CE pathway; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping" "24" "0" "0.962" "1.047" "1.026" "1.104" "1.061" "1.049" "1.052" "1.003" "1.096" "442.8" "425.9" "463.8" "454.3" "489.0" "469.8" "464.5" "465.9" "443.9" "485.1" "" "" "" "" "" "" "" "" "" "" "414.9" "352.5" "430.6" "351.2" "416.8" "448.9" "424.4" "413.7" "443.9" "467.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1377000983824553191" "False" "High" "IsMasterProtein" "Q8N5N7" "Large ribosomal subunit protein mL50 OS=Homo sapiens OX=9606 GN=MRPL50 PE=1 SV=2" "0.000" "False" "18.590" "36" "5" "5" "5" "158" "18.3" "7.88" "20.46" "5" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "" "Pf10501" "54534" "ENSG00000136897" "MRPL50" "B7Z358; hsa:54534; Q5T7E0; Q8N5N7; Q9NX15" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.985" "1.103" "1.025" "1.108" "1.086" "1.060" "1.045" "0.946" "1.089" "537.7" "529.8" "593.1" "551.2" "595.6" "583.8" "570.0" "562.0" "508.7" "585.7" "" "" "" "" "" "" "" "" "" "" "503.9" "438.4" "550.6" "426.1" "507.7" "557.8" "520.8" "499.0" "508.7" "564.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-493599392499449744" "False" "High" "IsMasterProtein" "P53990" "IST1 homolog OS=Homo sapiens OX=9606 GN=IST1 PE=1 SV=1" "0.000" "False" "18.571" "14" "6" "9" "6" "364" "39.7" "5.35" "32.31" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03398" "9798" "ENSG00000182149" "IST1" "A8KAH5; hsa:9798; J3QLU7; P53990; Q3SYM4; Q9BQ81; Q9BWN2" "" "Neutrophil degranulation; Sealing of the nuclear envelope (NE) by ESCRT-III" "2" "0" "1.032" "1.014" "1.107" "1.063" "1.319" "1.052" "1.077" "1.101" "1.183" "1053.4" "1087.4" "1068.4" "1166.5" "1119.7" "1389.1" "1108.2" "1134.5" "1159.8" "1246.4" "" "" "" "" "" "" "" "" "" "" "987.1" "899.8" "991.9" "901.7" "954.4" "1327.1" "1012.6" "1007.4" "1159.8" "1200.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3740771680866674362" "False" "High" "IsMasterProtein" "P62993" "Growth factor receptor-bound protein 2 OS=Homo sapiens OX=9606 GN=GRB2 PE=1 SV=1" "0.000" "False" "18.567" "29" "7" "11" "7" "217" "25.2" "6.32" "35.42" "7" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018" "2885" "ENSG00000177885" "GRB2" "hsa:2885; P29354; P62993; Q14450; Q63057; Q63059" "IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; IL-9 signaling pathway; Pilocytic astrocytoma; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; p38 MAPK signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; Thermogenesis; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 distal deletion syndrome; Modulators of TCR signaling and T cell activation; Kallmann syndrome; Pleural mesothelioma; Congenital generalized lipodystrophy; GDNF signaling; 2q13 copy number variation syndrome; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "Signaling by ALK fusions and activated point mutants; Signaling by CSF3 (G-CSF); Signaling by FLT3 ITD and TKD mutants; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling" "73" "0" "1.010" "0.977" "1.005" "0.976" "0.967" "0.962" "1.020" "0.943" "0.949" "1519.0" "1534.2" "1483.7" "1527.3" "1482.7" "1468.8" "1461.2" "1549.4" "1432.0" "1440.8" "" "" "" "" "" "" "" "" "" "" "1423.3" "1269.5" "1377.4" "1180.7" "1263.8" "1403.3" "1335.2" "1375.8" "1432.0" "1387.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7534759113121094513" "False" "High" "IsMasterProtein" "Q9Y3D9" "Small ribosomal subunit protein mS23 OS=Homo sapiens OX=9606 GN=MRPS23 PE=1 SV=2" "0.000" "False" "18.548" "31" "6" "12" "6" "190" "21.8" "8.90" "39.56" "6" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf10484" "51649" "ENSG00000181610" "MRPS23" "B2R6V3; hsa:51649; Q96Q24; Q9BWH8; Q9P053; Q9Y3D9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.035" "1.141" "0.988" "1.085" "1.091" "0.967" "0.941" "1.015" "1.048" "263.2" "272.4" "300.4" "260.1" "285.6" "287.1" "254.6" "247.8" "267.2" "275.8" "" "" "" "" "" "" "" "" "" "" "246.6" "225.4" "278.9" "201.1" "243.4" "274.3" "232.7" "220.0" "267.2" "265.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3464311242002607672" "False" "High" "IsMasterProtein" "P86790" "Vacuolar fusion protein CCZ1 homolog B OS=Homo sapiens OX=9606 GN=CCZ1B PE=1 SV=1" "0.000" "False" "18.544" "14" "7" "7" "7" "482" "55.8" "6.48" "16.65" "7" "transport" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf19031, Pf19032, Pf19033" "221960; 51622" "ENSG00000146574" "CCZ1B" "A2RU45; hsa:221960; hsa:51622; O95766; P86790; Q9UG65; Q9Y359" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.010" "1.121" "1.122" "1.015" "1.004" "0.926" "0.938" "0.964" "0.984" "742.0" "749.4" "832.0" "832.6" "753.2" "745.1" "687.3" "695.8" "715.3" "730.3" "" "" "" "" "" "" "" "" "" "" "695.2" "620.2" "772.4" "643.7" "642.0" "711.8" "628.0" "617.8" "715.3" "703.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3677224009341935597" "False" "High" "IsMasterProtein" "P48729" "Casein kinase I isoform alpha OS=Homo sapiens OX=9606 GN=CSNK1A1 PE=1 SV=2" "0.000" "False" "18.526" "18" "5" "7" "5" "337" "38.9" "9.57" "23.74" "5" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1452" "ENSG00000113712" "CSNK1A1" "D3DQG0; D3DQG1; hsa:1452; P48729; Q4JJA0; Q5U046; Q5U047; Q6FGA2; Q71TU5; Q96HD2; Q9UDK3" "Alzheimer's disease and miRNA effects; T cell receptor and co-stimulatory signaling; Complement system; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Chromosomal and microsatellite instability in colorectal cancer ; Hedgehog signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Alzheimer's disease; DYRK1A involvement regarding cell proliferation in brain development" "Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Activation of SMO; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Maturation of nucleoprotein" "32" "0" "1.042" "1.051" "1.109" "1.125" "1.064" "1.074" "1.077" "1.108" "1.136" "288.0" "300.0" "302.6" "319.2" "324.0" "306.3" "309.2" "310.0" "319.0" "327.1" "" "" "" "" "" "" "" "" "" "" "269.8" "248.2" "280.9" "246.8" "276.2" "292.6" "282.6" "275.3" "319.0" "314.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6302134313779443403" "False" "High" "IsMasterProtein" "Q96ER3" "Protein SAAL1 OS=Homo sapiens OX=9606 GN=SAAL1 PE=1 SV=2" "0.000" "False" "18.517" "12" "7" "10" "7" "474" "53.5" "4.50" "34.60" "7" "other biological processes" "nucleus" "" "" "113174" "ENSG00000166788" "SAAL1" "A6NH05; hsa:113174; Q96ER3" "" "" "0" "0" "0.979" "0.991" "1.015" "0.957" "0.981" "0.965" "1.003" "0.926" "0.996" "1157.5" "1133.2" "1147.4" "1175.0" "1107.4" "1136.0" "1116.6" "1160.9" "1071.9" "1153.1" "" "" "" "" "" "" "" "" "" "" "1084.6" "937.7" "1065.2" "908.3" "943.9" "1085.3" "1020.3" "1030.8" "1071.9" "1110.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9109513475254745228" "False" "High" "IsMasterProtein" "Q9UBD5" "Origin recognition complex subunit 3 OS=Homo sapiens OX=9606 GN=ORC3 PE=1 SV=1" "0.000" "False" "18.496" "8" "7" "8" "7" "711" "82.2" "7.61" "20.44" "7" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07034, Pf18137, Pf19675" "23595" "ENSG00000135336" "ORC3" "A2A2T5; B4E025; hsa:23595; Q13565; Q53GY6; Q5T159; Q6IUY7; Q86TN5; Q9UBD5; Q9UG44; Q9UNT6" "Cell cycle; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the ORC complex at the origin of replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; CDC6 association with the ORC:origin complex" "10" "0" "0.998" "0.992" "1.051" "1.017" "1.058" "0.973" "0.962" "1.031" "1.050" "577.1" "576.0" "572.5" "606.9" "587.1" "610.7" "561.4" "555.2" "594.8" "606.0" "" "" "" "" "" "" "" "" "" "" "540.8" "476.6" "531.5" "469.1" "500.4" "583.5" "513.0" "492.9" "594.8" "583.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7001709167677346758" "False" "High" "IsMasterProtein" "Q9Y305" "Acyl-coenzyme A thioesterase 9, mitochondrial OS=Homo sapiens OX=9606 GN=ACOT9 PE=1 SV=2" "0.000" "False" "18.493" "11" "5" "6" "5" "439" "49.9" "8.60" "17.64" "5" "other metabolic processes" "mitochondrion" "other molecular function" "" "23597" "ENSG00000123130" "ACOT9" "B3KNC9; B7ZM94; hsa:23597; Q9Y305" "VEGFA-VEGFR2 signaling" "Mitochondrial Fatty Acid Beta-Oxidation" "2" "0" "1.057" "1.043" "0.973" "1.034" "1.008" "0.971" "0.994" "1.043" "1.025" "618.7" "653.7" "645.2" "602.0" "640.0" "623.4" "601.0" "615.1" "645.3" "634.0" "" "" "" "" "" "" "" "" "" "" "579.7" "540.9" "599.0" "465.4" "545.5" "595.6" "549.1" "546.1" "645.3" "610.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1714630333721311506" "False" "High" "IsMasterProtein" "Q6NVY1" "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HIBCH PE=1 SV=2" "0.000" "False" "18.492" "18" "7" "10" "7" "386" "43.5" "8.19" "27.85" "7" "other metabolic processes" "mitochondrion" "other molecular function" "Pf16113" "26275" "ENSG00000198130" "HIBCH" "D3DPI4; hsa:26275; Q53GA8; Q53GF2; Q53RF7; Q53TC6; Q6NVY1; Q92931; Q9BS94" "Amino acid metabolism" "Branched-chain amino acid catabolism" "2" "0" "0.972" "1.058" "1.081" "1.098" "1.188" "1.129" "1.088" "1.081" "1.068" "422.3" "410.7" "446.6" "456.5" "463.7" "501.8" "476.7" "459.3" "456.6" "450.9" "" "" "" "" "" "" "" "" "" "" "395.7" "339.8" "414.6" "352.9" "395.2" "479.5" "435.6" "407.8" "456.6" "434.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "515980508248597386" "False" "High" "IsMasterProtein" "Q5T1V6" "Probable ATP-dependent RNA helicase DDX59 OS=Homo sapiens OX=9606 GN=DDX59 PE=1 SV=1" "0.000" "False" "18.470" "10" "6" "6" "6" "619" "68.8" "7.44" "19.31" "6" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04438" "83479" "ENSG00000118197" "DDX59" "hsa:83479; Q5T1V6; Q6PJL2; Q8IVW3; Q9H0W3" "Ciliopathies" "" "1" "0" "1.021" "1.001" "1.021" "1.050" "1.029" "0.959" "1.005" "1.002" "1.005" "595.8" "608.5" "596.1" "608.1" "625.5" "613.1" "571.3" "598.9" "596.9" "598.6" "" "" "" "" "" "" "" "" "" "" "558.2" "503.5" "553.4" "470.1" "533.1" "585.8" "522.0" "531.8" "596.9" "576.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6296603921804072395" "False" "High" "IsMasterProtein" "Q9NSV4" "Protein diaphanous homolog 3 OS=Homo sapiens OX=9606 GN=DIAPH3 PE=1 SV=4" "0.000" "False" "18.460" "7" "8" "9" "8" "1193" "136.8" "7.03" "28.85" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf02181, Pf06367, Pf06371" "81624" "ENSG00000139734" "DIAPH3" "A2A3B8; A2A3B9; A2A3C0; hsa:81624; Q18P99; Q18PA0; Q18PA1; Q2KPB6; Q3ZK23; Q5JTP8; Q5T2S7; Q5XKF6; Q6MZF0; Q6NUP0; Q86VS4; Q8NAV4; Q9NSV4" "Regulation of actin cytoskeleton" "RHO GTPases Activate Formins; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle" "14" "0" "0.946" "1.009" "0.993" "1.003" "1.010" "0.958" "0.970" "1.016" "1.039" "1586.2" "1500.2" "1600.6" "1574.4" "1590.6" "1601.6" "1519.6" "1539.0" "1611.2" "1648.1" "" "" "" "" "" "" "" "" "" "" "1486.2" "1241.4" "1485.9" "1217.1" "1355.8" "1530.2" "1388.5" "1366.4" "1611.2" "1586.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1943269179949256185" "False" "High" "IsMasterProtein" "Q96B70" "Leukocyte receptor cluster member 9 OS=Homo sapiens OX=9606 GN=LENG9 PE=1 SV=2" "0.000" "False" "18.458" "13" "5" "5" "5" "501" "53.1" "7.84" "17.49" "5" "" "" "other molecular function" "Pf00642, Pf04457, Pf10469" "" "ENSG00000273574; ENSG00000274495" "LENG9" "B2VAM3; Q96B70" "" "" "0" "0" "1.354" "1.061" "1.189" "1.203" "1.093" "1.153" "1.047" "1.155" "1.158" "228.1" "308.7" "241.9" "271.2" "274.4" "249.3" "262.8" "238.9" "263.4" "264.1" "" "" "" "" "" "" "" "" "" "" "213.7" "255.4" "224.6" "209.6" "233.9" "238.1" "240.2" "212.1" "263.4" "254.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7105590479105363220" "False" "High" "IsMasterProtein" "O60870" "DNA/RNA-binding protein KIN17 OS=Homo sapiens OX=9606 GN=KIN PE=1 SV=2" "0.000" "False" "18.457" "16" "7" "8" "7" "393" "45.3" "8.95" "24.06" "7" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10357, Pf18131" "22944" "ENSG00000151657" "KIN" "B4DX32; hsa:22944; O60870" "" "Protein methylation" "1" "0" "1.020" "1.063" "1.100" "1.106" "1.114" "1.099" "1.133" "1.114" "1.130" "1265.4" "1290.9" "1345.6" "1392.1" "1399.0" "1410.2" "1390.3" "1433.6" "1410.1" "1429.4" "" "" "" "" "" "" "" "" "" "" "1185.6" "1068.2" "1249.3" "1076.1" "1192.5" "1347.3" "1270.4" "1272.9" "1410.1" "1376.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6689030380433317187" "False" "High" "IsMasterProtein" "Q01543" "Friend leukemia integration 1 transcription factor OS=Homo sapiens OX=9606 GN=FLI1 PE=1 SV=1" "0.000" "False" "18.456" "19" "6" "7" "5" "452" "51.0" "7.06" "23.77" "6" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198" "2313" "ENSG00000151702" "FLI1" "B2R8H2; B4DFV4; B4DTC6; G3V183; hsa:2313; Q01543; Q14319; Q92480; Q9UE07" "Hematopoietic stem cell differentiation" "Transcriptional regulation of granulopoiesis" "2" "1" "0.990" "1.040" "1.037" "1.045" "1.058" "0.987" "0.991" "1.091" "1.031" "958.1" "948.6" "995.9" "993.7" "1001.3" "1013.9" "945.7" "949.0" "1045.4" "987.5" "" "" "" "" "" "" "" "" "" "" "897.7" "784.9" "924.6" "768.1" "853.5" "968.7" "864.1" "842.7" "1045.4" "950.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "575665869234459474" "False" "High" "IsMasterProtein" "P42331" "Rho GTPase-activating protein 25 OS=Homo sapiens OX=9606 GN=ARHGAP25 PE=1 SV=2" "0.000" "False" "18.421" "12" "9" "12" "9" "645" "73.4" "6.37" "28.10" "9" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane" "enzyme regulator activity" "Pf00169, Pf00620" "9938" "ENSG00000163219" "ARHGAP25" "A8K2Y1; B7Z498; E9PFQ7; G5E9G2; hsa:9938; P42331; Q8IXQ2" "" "RAC1 GTPase cycle" "1" "0" "0.940" "0.950" "0.976" "0.961" "0.973" "0.993" "0.961" "0.897" "0.943" "1402.7" "1319.2" "1332.9" "1369.6" "1347.9" "1364.9" "1393.3" "1347.5" "1257.6" "1322.7" "" "" "" "" "" "" "" "" "" "" "1314.3" "1091.6" "1237.4" "1058.8" "1149.0" "1304.0" "1273.1" "1196.5" "1257.6" "1273.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5392183546824292188" "False" "High" "IsMasterProtein" "Q8NEY1" "Neuron navigator 1 OS=Homo sapiens OX=9606 GN=NAV1 PE=1 SV=2" "0.000" "False" "18.408" "4" "7" "7" "7" "1877" "202.3" "8.07" "19.95" "7" "cell organization and biogenesis;developmental processes" "cytoskeleton;other cell component" "other molecular function" "" "89796" "ENSG00000134369" "NAV1" "A8MS88; hsa:89796; Q5SVH1; Q5SVH2; Q5SVH3; Q5SVH7; Q5VUY9; Q8IVL2; Q8NEY1; Q96II1; Q9H7V9; Q9H9S9; Q9H9T5; Q9UGI1; Q9ULK7; Q9ULR9" "" "" "0" "0" "0.991" "1.021" "1.033" "1.019" "0.999" "0.998" "1.007" "1.006" "1.031" "1074.8" "1065.3" "1096.9" "1109.8" "1095.6" "1073.7" "1073.1" "1081.8" "1080.9" "1107.6" "" "" "" "" "" "" "" "" "" "" "1007.1" "881.6" "1018.4" "857.9" "933.9" "1025.8" "980.5" "960.6" "1080.9" "1066.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-288326920404565316" "False" "High" "IsMasterProtein" "O15111" "Inhibitor of nuclear factor kappa-B kinase subunit alpha OS=Homo sapiens OX=9606 GN=CHUK PE=1 SV=2" "0.000" "False" "18.402" "8" "7" "8" "6" "745" "84.6" "6.73" "23.36" "7" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf12179, Pf18397" "1147" "ENSG00000213341" "CHUK" "hsa:1147; O14666; O15111; Q13132; Q5W0I4; Q92467" "Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Canonical and non-canonical Notch signaling; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; Chemokine signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; T-cell receptor signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; PKR-mediated signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Constitutive Signaling by AKT1 E17K in Cancer; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; AKT phosphorylates targets in the cytosol" "86" "0" "0.939" "0.981" "1.025" "1.044" "0.982" "0.965" "0.948" "0.931" "0.940" "361.8" "339.7" "354.8" "370.9" "377.6" "355.4" "349.1" "343.1" "336.9" "340.2" "" "" "" "" "" "" "" "" "" "" "339.0" "281.1" "329.4" "286.7" "321.9" "339.6" "319.0" "304.6" "336.9" "327.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8622361133611111311" "False" "High" "IsMasterProtein" "O14936" "Peripheral plasma membrane protein CASK OS=Homo sapiens OX=9606 GN=CASK PE=1 SV=3" "0.000" "False" "18.371" "8" "6" "7" "6" "926" "105.1" "6.43" "18.21" "6" "cell adhesion;other metabolic processes;transport;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf00595, Pf00625, Pf02828, Pf07653" "8573" "ENSG00000147044" "CASK" "A6NES1; B7ZKY0; hsa:8573; O14936; O43215; Q17RI4; Q59HA0; Q5VT16; Q5VT17; Q5VT18; Q5VT19; Q66T42; Q9BYH6; Q9NYB2; Q9NYB3" "Parkin-ubiquitin proteasomal system pathway; Splicing factor NOVA regulated synaptic proteins; Cell lineage map for neuronal differentiation" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Assembly and cell surface presentation of NMDA receptors; Nephrin family interactions; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle; Syndecan interactions" "10" "0" "1.008" "1.078" "1.126" "1.095" "1.061" "1.093" "1.112" "1.049" "1.012" "465.9" "469.8" "502.3" "524.5" "510.1" "494.1" "509.3" "518.1" "488.6" "471.2" "" "" "" "" "" "" "" "" "" "" "436.5" "388.7" "466.3" "405.5" "434.8" "472.1" "465.4" "460.0" "488.6" "453.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7190222159830229495" "False" "High" "IsMasterProtein" "Q9H0A0" "RNA cytidine acetyltransferase OS=Homo sapiens OX=9606 GN=NAT10 PE=1 SV=2" "0.000" "False" "18.366" "8" "7" "7" "7" "1025" "115.7" "8.27" "20.88" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05127, Pf08351, Pf13718, Pf13725" "55226" "ENSG00000135372" "NAT10" "B4DFD5; E7ESU4; E9PMN9; hsa:55226; Q86WK5; Q9C0F4; Q9H0A0; Q9HA61; Q9NVF2" "Metapathway biotransformation Phase I and II" "rRNA modification in the nucleus and cytosol" "2" "0" "1.088" "1.106" "1.193" "1.245" "1.185" "1.284" "1.400" "1.273" "1.253" "498.6" "542.6" "551.3" "594.7" "621.0" "590.7" "640.2" "698.2" "634.7" "624.8" "" "" "" "" "" "" "" "" "" "" "467.2" "449.0" "511.8" "459.8" "529.4" "564.4" "585.0" "619.9" "634.7" "601.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2393292125676734128" "False" "High" "IsMasterProtein" "Q8IWY9" "Codanin-1 OS=Homo sapiens OX=9606 GN=CDAN1 PE=1 SV=4" "0.000" "False" "18.349" "4" "6" "6" "5" "1227" "134.0" "6.77" "19.06" "6" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf15296" "146059" "ENSG00000140326" "CDAN1" "hsa:146059; Q6NYD0; Q7Z7L5; Q8IWY9; Q969N3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9217624131527771053" "False" "High" "IsMasterProtein" "O00330" "Pyruvate dehydrogenase protein X component, mitochondrial OS=Homo sapiens OX=9606 GN=PDHX PE=1 SV=3" "0.000" "False" "18.345" "10" "6" "8" "6" "501" "54.1" "8.66" "17.20" "6" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00198, Pf00364, Pf02817" "8050" "ENSG00000110435" "PDHX" "B4DW62; D3DR11; E9PB14; E9PBP7; hsa:8050; O00330; O60221; Q96FV8; Q99783" "Amino acid metabolism" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "5" "0" "1.066" "1.048" "1.095" "1.093" "1.042" "1.040" "1.053" "1.034" "1.030" "1074.2" "1144.7" "1126.2" "1175.9" "1174.6" "1119.3" "1117.0" "1131.4" "1111.1" "1106.2" "" "" "" "" "" "" "" "" "" "" "1006.5" "947.2" "1045.5" "909.0" "1001.2" "1069.3" "1020.6" "1004.6" "1111.1" "1065.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7401329575601911727" "False" "High" "IsMasterProtein" "P13674" "Prolyl 4-hydroxylase subunit alpha-1 OS=Homo sapiens OX=9606 GN=P4HA1 PE=1 SV=2" "0.000" "False" "18.334" "13" "7" "10" "7" "534" "61.0" "6.01" "30.70" "7" "cell organization and biogenesis" "mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf08336, Pf13640" "5033" "ENSG00000122884" "P4HA1" "C9JL12; hsa:5033; P13674; Q15082; Q15083; Q5VSQ5" "Type I collagen synthesis in the context of osteogenesis imperfecta" "Collagen biosynthesis and modifying enzymes" "2" "0" "0.980" "1.043" "0.983" "0.989" "1.004" "0.987" "0.983" "1.020" "1.027" "737.6" "722.5" "768.9" "724.7" "729.8" "740.7" "727.9" "725.4" "752.1" "757.2" "" "" "" "" "" "" "" "" "" "" "691.1" "597.8" "713.9" "560.2" "622.1" "707.6" "665.1" "644.0" "752.1" "729.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4002844298631346291" "False" "High" "IsMasterProtein" "Q53H47" "Histone-lysine N-methyltransferase SETMAR OS=Homo sapiens OX=9606 GN=SETMAR PE=1 SV=2" "0.000" "False" "18.329" "8" "6" "7" "6" "684" "78.0" "7.14" "24.46" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00856, Pf01359, Pf05033, Pf17906" "6419" "ENSG00000170364" "SETMAR" "B4DY74; E7EN68; hsa:6419; Q13579; Q1G668; Q53H47; Q96F41" "Histone modifications" "" "1" "0" "0.993" "1.010" "0.998" "1.007" "1.023" "1.028" "0.977" "1.045" "1.023" "794.7" "789.0" "802.6" "793.0" "799.9" "812.7" "816.8" "776.6" "830.4" "812.9" "" "" "" "" "" "" "" "" "" "" "744.7" "652.9" "745.1" "613.0" "681.9" "776.5" "746.4" "689.5" "830.4" "782.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3427598645898203721" "False" "High" "IsMasterProtein" "O14828" "Secretory carrier-associated membrane protein 3 OS=Homo sapiens OX=9606 GN=SCAMP3 PE=1 SV=3" "0.000" "False" "18.306" "21" "6" "8" "6" "347" "38.3" "7.64" "24.19" "6" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04144" "10067" "ENSG00000116521; ENSG00000263290" "SCAMP3" "A9Z1W6; B1AVS6; hsa:10067; O14828; O15128; Q96FR8; Q9BPY0" "" "" "0" "0" "1.032" "0.949" "1.054" "0.988" "1.072" "1.022" "1.024" "1.094" "1.003" "1105.9" "1141.3" "1049.5" "1165.4" "1092.2" "1186.1" "1130.0" "1132.5" "1209.4" "1109.2" "" "" "" "" "" "" "" "" "" "" "1036.3" "944.4" "974.3" "900.9" "930.9" "1133.2" "1032.5" "1005.6" "1209.4" "1068.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1314773965349869651" "False" "High" "IsMasterProtein" "Q9BRP8" "Partner of Y14 and mago OS=Homo sapiens OX=9606 GN=PYM1 PE=1 SV=1" "0.000" "False" "18.306" "34" "5" "6" "5" "204" "22.6" "9.45" "22.70" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf09282" "84305" "ENSG00000170473" "PYM1" "B6ZDM5; hsa:84305; Q8IXJ8; Q8N8E7; Q9BRP8" "TAR syndrome" "" "1" "0" "1.016" "1.011" "0.924" "0.976" "0.910" "0.723" "0.796" "0.751" "0.922" "779.6" "791.9" "787.9" "720.1" "760.8" "709.5" "563.6" "620.4" "585.2" "719.0" "" "" "" "" "" "" "" "" "" "" "730.5" "655.3" "731.5" "556.7" "648.5" "677.9" "515.0" "550.9" "585.2" "692.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-720179637671099041" "False" "High" "IsMasterProtein" "Q06546" "GA-binding protein alpha chain OS=Homo sapiens OX=9606 GN=GABPA PE=1 SV=1" "0.000" "False" "18.292" "15" "6" "8" "6" "454" "51.3" "4.97" "28.67" "6" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198, Pf11620" "2551" "ENSG00000154727" "GABPA" "hsa:2551; Q06546; Q12939" "Energy metabolism; Allograft rejection; Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression; Pleural mesothelioma" "Transcriptional activation of mitochondrial biogenesis" "7" "0" "1.041" "1.056" "1.062" "1.102" "1.033" "1.018" "1.013" "1.116" "1.049" "601.8" "626.3" "635.2" "639.3" "663.1" "621.5" "612.8" "609.4" "671.6" "631.2" "" "" "" "" "" "" "" "" "" "" "563.9" "518.3" "589.7" "494.2" "565.2" "593.8" "559.9" "541.1" "671.6" "607.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4889317708786741676" "False" "High" "IsMasterProtein" "Q96AT1" "Uncharacterized protein KIAA1143 OS=Homo sapiens OX=9606 GN=KIAA1143 PE=1 SV=2" "0.000" "False" "18.290" "34" "5" "10" "5" "154" "17.5" "6.11" "27.46" "5" "" "" "" "Pf15377" "57456" "ENSG00000163807; ENSG00000281665" "KIAA1143" "A8K0I4; hsa:57456; Q96AT1; Q96HJ8; Q9ULS7" "" "" "0" "0" "1.047" "0.862" "1.062" "0.972" "0.916" "0.922" "1.094" "0.931" "1.088" "156.6" "164.0" "135.0" "166.4" "152.2" "143.5" "144.4" "171.3" "145.8" "170.5" "" "" "" "" "" "" "" "" "" "" "146.8" "135.7" "125.4" "128.6" "129.7" "137.1" "131.9" "152.1" "145.8" "164.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570733689934674061" "False" "High" "IsMasterProtein" "P61106" "Ras-related protein Rab-14 OS=Homo sapiens OX=9606 GN=RAB14 PE=1 SV=4" "0.000" "False" "18.283" "31" "7" "7" "6" "215" "23.9" "6.21" "22.45" "7" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "51552" "ENSG00000119396" "RAB14" "B3KR31; hsa:51552; P35287; P61106; Q5JVD4; Q6Q7K5; Q969L0; Q9UI11" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape" "RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Synthesis of PIPs at the plasma membrane" "7" "0" "0.896" "0.994" "0.894" "0.947" "0.969" "0.943" "0.941" "0.960" "0.925" "1603.1" "1436.5" "1593.5" "1432.6" "1518.5" "1552.8" "1512.3" "1507.9" "1539.6" "1483.5" "" "" "" "" "" "" "" "" "" "" "1502.1" "1188.6" "1479.4" "1107.5" "1294.3" "1483.6" "1381.9" "1338.9" "1539.6" "1428.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4865445723935678396" "False" "High" "IsMasterProtein" "Q13309" "S-phase kinase-associated protein 2 OS=Homo sapiens OX=9606 GN=SKP2 PE=1 SV=2" "0.000" "False" "18.269" "15" "6" "8" "6" "424" "47.7" "7.11" "26.64" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12937" "6502" "ENSG00000145604" "SKP2" "A8K5E0; B4DJT4; hsa:6502; Q13309; Q8TDZ0; Q8TDZ1; Q9BV69" "Cell cycle; Retinoblastoma gene in cancer; Imatinib and chronic myeloid leukemia" "Ub-specific processing proteases; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Aberrant regulation of mitotic exit in cancer due to RB1 defects; Orc1 removal from chromatin; Regulation of RUNX2 expression and activity; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; Cyclin D associated events in G1; Regulation of BACH1 activity" "13" "0" "1.071" "1.064" "1.134" "1.086" "1.067" "1.086" "1.027" "1.030" "1.038" "627.1" "671.3" "667.1" "711.0" "680.7" "669.0" "680.9" "644.2" "645.8" "651.0" "" "" "" "" "" "" "" "" "" "" "587.6" "555.5" "619.4" "549.6" "580.2" "639.1" "622.2" "572.0" "645.8" "626.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6962760823323839829" "False" "High" "IsMasterProtein" "O43681" "ATPase GET3 OS=Homo sapiens OX=9606 GN=GET3 PE=1 SV=2" "0.000" "False" "18.257" "15" "5" "7" "5" "348" "38.8" "4.91" "19.81" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf02374" "439" "ENSG00000198356" "GET3" "A6NHP8; A8K740; hsa:439; O43681; Q53FC6; Q92849" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "0.942" "1.026" "0.971" "0.946" "0.974" "0.999" "1.004" "1.037" "1.023" "714.5" "673.2" "733.4" "693.6" "676.1" "696.1" "713.5" "717.3" "740.7" "731.2" "" "" "" "" "" "" "" "" "" "" "669.5" "557.0" "680.9" "536.2" "576.2" "665.0" "651.9" "636.9" "740.7" "704.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4549741875275556482" "False" "High" "IsMasterProtein" "Q99627" "COP9 signalosome complex subunit 8 OS=Homo sapiens OX=9606 GN=COPS8 PE=1 SV=1" "0.000" "False" "18.252" "35" "5" "8" "5" "209" "23.2" "5.38" "28.50" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10075" "10920" "ENSG00000198612" "COPS8" "A8K1H6; hsa:10920; Q53QS9; Q99627" "Ciliary landscape; 2q37 copy number variation syndrome" "Neddylation; DNA Damage Recognition in GG-NER; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex" "6" "0" "1.102" "0.997" "1.173" "1.150" "1.083" "1.041" "1.010" "1.096" "1.050" "328.2" "361.6" "327.3" "385.0" "377.4" "355.3" "341.7" "331.3" "359.8" "344.5" "" "" "" "" "" "" "" "" "" "" "307.5" "299.2" "303.8" "297.7" "321.6" "339.4" "312.2" "294.2" "359.8" "331.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200038646673232615" "False" "High" "IsMasterProtein" "Q9P287" "BRCA2 and CDKN1A-interacting protein OS=Homo sapiens OX=9606 GN=BCCIP PE=1 SV=1" "0.000" "False" "18.222" "22" "6" "7" "6" "314" "36.0" "4.61" "22.23" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus" "enzyme regulator activity;cytoskeletal activity" "Pf13862" "56647" "ENSG00000107949" "BCCIP" "B3KP45; hsa:56647; Q8ND15; Q96GC4; Q9P287; Q9P288" "" "" "0" "0" "0.993" "1.019" "0.955" "0.983" "1.039" "1.038" "1.031" "0.965" "0.969" "591.3" "587.2" "602.5" "564.5" "581.2" "614.6" "613.6" "609.5" "570.5" "573.1" "" "" "" "" "" "" "" "" "" "" "554.1" "485.9" "559.3" "436.4" "495.4" "587.2" "560.6" "541.2" "570.5" "551.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7857902194460077614" "False" "High" "IsMasterProtein" "Q13535" "Serine/threonine-protein kinase ATR OS=Homo sapiens OX=9606 GN=ATR PE=1 SV=3" "0.000" "False" "18.221" "3" "8" "8" "8" "2644" "301.2" "7.43" "18.02" "8" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08064" "545" "ENSG00000175054" "ATR" "hsa:545; Q13535; Q59HB2; Q7KYL3; Q93051; Q9BXK4" "miRNA regulation of DNA damage response; Cell cycle; ATR signaling; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; NIPBL role in DNA damage - Cornelia de Lange syndrome; DNA damage response" "TP53 Regulates Transcription of DNA Repair Genes; Meiotic synapsis; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "19" "0" "0.869" "1.029" "0.950" "0.994" "1.071" "0.980" "0.996" "0.908" "0.974" "385.9" "335.4" "396.9" "366.7" "383.7" "413.1" "378.1" "384.2" "350.4" "375.7" "" "" "" "" "" "" "" "" "" "" "361.6" "277.6" "368.5" "283.5" "327.0" "394.7" "345.5" "341.2" "350.4" "361.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7164252361216930989" "False" "High" "IsMasterProtein" "P27707" "Deoxycytidine kinase OS=Homo sapiens OX=9606 GN=DCK PE=1 SV=1" "0.000" "False" "18.218" "18" "5" "7" "5" "260" "30.5" "5.21" "25.75" "5" "other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf01712" "1633" "ENSG00000156136" "DCK" "B2R8V6; hsa:1633; P27707; Q5TZY7; Q6FI11" "Retinoblastoma gene in cancer; Pyrimidine metabolism" "Pyrimidine salvage; Purine salvage" "4" "0" "1.042" "0.939" "1.007" "0.968" "0.966" "0.862" "1.058" "1.011" "0.979" "1221.3" "1272.3" "1146.9" "1229.5" "1182.0" "1179.5" "1052.3" "1292.3" "1234.2" "1195.5" "" "" "" "" "" "" "" "" "" "" "1144.4" "1052.8" "1064.8" "950.5" "1007.5" "1126.9" "961.6" "1147.4" "1234.2" "1151.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7032726270839277036" "False" "High" "IsMasterProtein" "P27144" "Adenylate kinase 4, mitochondrial OS=Homo sapiens OX=9606 GN=AK4 PE=1 SV=1" "0.000" "False" "18.207" "26" "6" "12" "6" "223" "25.3" "8.40" "33.93" "6" "other metabolic processes;stress response;other biological processes" "mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "205" "ENSG00000162433" "AK4" "B2R927; D3DQ62; hsa:205; P27144; Q6IBH4; Q6NXQ5; Q8IUU9" "CCL18 signaling pathway" "Interconversion of nucleotide di- and triphosphates" "2" "0" "0.990" "1.025" "0.987" "1.018" "0.995" "0.971" "0.987" "0.939" "0.953" "1161.3" "1149.1" "1190.7" "1145.7" "1182.4" "1155.2" "1127.8" "1146.5" "1090.1" "1107.1" "" "" "" "" "" "" "" "" "" "" "1088.1" "950.9" "1105.4" "885.7" "1007.8" "1103.7" "1030.5" "1018.0" "1090.1" "1065.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6090359432096684388" "False" "High" "IsMasterProtein" "Q8NCN5" "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Homo sapiens OX=9606 GN=PDPR PE=1 SV=2" "0.000" "False" "18.200" "8" "7" "7" "7" "879" "99.3" "6.35" "21.31" "7" "" "mitochondrion;other cell component" "other molecular function" "Pf01266, Pf01571, Pf08669, Pf16350" "55066" "ENSG00000090857" "PDPR" "A7E298; A8K8Y7; B3KSE1; Q6AI20; Q6AWC9; Q8NCN5" "" "Regulation of pyruvate dehydrogenase (PDH) complex" "1" "0" "1.028" "0.979" "1.075" "0.984" "1.062" "1.002" "0.959" "0.974" "1.021" "487.1" "500.6" "476.8" "523.8" "479.1" "517.2" "488.2" "467.1" "474.3" "497.5" "" "" "" "" "" "" "" "" "" "" "456.4" "414.2" "442.6" "404.9" "408.4" "494.2" "446.1" "414.7" "474.3" "479.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8110306690791428834" "False" "High" "IsMasterProtein" "P29218" "Inositol monophosphatase 1 OS=Homo sapiens OX=9606 GN=IMPA1 PE=1 SV=1" "0.000" "False" "18.178" "22" "5" "6" "5" "277" "30.2" "5.26" "26.61" "5" "other metabolic processes;signal transduction" "cytosol;other cell component" "other molecular function" "Pf00459" "3612" "ENSG00000133731" "IMPA1" "B2R733; B4DLN3; B7Z6Q4; J3KQT7; P29218; Q9UK71" "" "Synthesis of IP2, IP, and Ins in the cytosol" "1" "0" "1.049" "1.041" "0.967" "1.029" "1.046" "0.988" "1.019" "1.035" "1.022" "967.1" "1014.5" "1006.6" "935.5" "994.7" "1011.1" "955.9" "985.7" "1001.4" "988.3" "" "" "" "" "" "" "" "" "" "" "906.2" "839.5" "934.5" "723.2" "847.9" "966.1" "873.4" "875.2" "1001.4" "951.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4163681238843766636" "False" "High" "IsMasterProtein" "Q13144" "Translation initiation factor eIF2B subunit epsilon OS=Homo sapiens OX=9606 GN=EIF2B5 PE=1 SV=3" "0.000" "False" "18.173" "9" "5" "7" "5" "721" "80.3" "5.08" "28.42" "5" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf02020" "8893" "ENSG00000145191" "EIF2B5" "hsa:8893; Q13144; Q541Z1; Q96D04" "Translation factors; MicroRNAs in cardiomyocyte hypertrophy; DYRK1A involvement regarding cell proliferation in brain development; Primary ovarian insufficiency" "Recycling of eIF2:GDP" "5" "0" "1.013" "0.948" "0.934" "0.944" "0.966" "0.920" "0.833" "0.942" "0.939" "763.5" "773.1" "723.4" "712.7" "720.5" "737.3" "702.3" "635.8" "719.0" "717.1" "" "" "" "" "" "" "" "" "" "" "715.4" "639.7" "671.6" "551.0" "614.2" "704.5" "641.7" "564.5" "719.0" "690.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8115574768027660471" "False" "High" "IsMasterProtein" "P30837" "Aldehyde dehydrogenase X, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH1B1 PE=1 SV=4" "0.000" "False" "18.149" "13" "6" "7" "5" "517" "57.2" "6.99" "23.73" "6" "other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00171" "219" "ENSG00000137124" "ALDH1B1" "B2R8F0; hsa:219; P30837; Q8WX76; Q9BV45" "" "Mitochondrial protein degradation; Ethanol oxidation" "2" "0" "0.961" "0.978" "1.060" "1.069" "1.014" "0.977" "0.983" "0.953" "0.942" "139.9" "134.5" "136.9" "148.4" "149.6" "141.8" "136.8" "137.6" "133.4" "131.8" "" "" "" "" "" "" "" "" "" "" "131.1" "111.3" "127.1" "114.7" "127.5" "135.5" "125.0" "122.2" "133.4" "126.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2794156240078795368" "False" "High" "IsMasterProtein" "Q8NEZ5" "F-box only protein 22 OS=Homo sapiens OX=9606 GN=FBXO22 PE=1 SV=1" "0.000" "False" "18.113" "14" "5" "8" "5" "403" "44.5" "7.03" "23.17" "5" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00646, Pf10442" "26263" "ENSG00000167196" "FBXO22" "hsa:26263; Q0D2P8; Q6PIL5; Q8IXW3; Q8NEZ5; Q9H824; Q9UKC0" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.039" "1.045" "1.080" "1.091" "1.062" "1.146" "1.109" "1.077" "1.026" "283.1" "294.0" "295.9" "305.7" "309.0" "300.5" "324.3" "314.0" "304.8" "290.3" "" "" "" "" "" "" "" "" "" "" "265.2" "243.3" "274.7" "236.3" "263.3" "287.1" "296.3" "278.8" "304.8" "279.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-309007205683403427" "False" "High" "IsMasterProtein" "Q8IWS0" "PHD finger protein 6 OS=Homo sapiens OX=9606 GN=PHF6 PE=1 SV=1" "0.000" "False" "18.105" "14" "5" "13" "5" "365" "41.3" "8.68" "33.19" "5" "developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf13771" "84295" "ENSG00000156531" "PHF6" "A8K230; B4E0G4; D3DTG3; E9PC97; hsa:84295; Q5JRC7; Q5JRC8; Q8IWS0; Q96JK3; Q9BRU0" "Mesodermal commitment pathway" "" "1" "0" "0.987" "1.008" "1.014" "1.023" "1.005" "1.088" "1.088" "1.060" "1.071" "532.3" "525.1" "536.4" "539.6" "544.4" "534.7" "578.9" "579.2" "563.9" "569.9" "" "" "" "" "" "" "" "" "" "" "498.7" "434.5" "498.0" "417.2" "464.0" "510.9" "529.0" "514.3" "563.9" "548.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4066776278631376418" "False" "High" "IsMasterProtein" "P17612" "cAMP-dependent protein kinase catalytic subunit alpha OS=Homo sapiens OX=9606 GN=PRKACA PE=1 SV=2" "0.000" "False" "18.089" "17" "6" "8" "2" "351" "40.6" "8.79" "23.95" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5566" "ENSG00000072062; ENSG00000288516" "PRKACA" "hsa:5566; P17612; Q32P54; Q9H2Y0; Q9NRB4; Q9NRH9" "Nicotine effect on dopaminergic neurons; Sterol regulatory element-binding proteins (SREBP) signaling; Follicle stimulating hormone (FSH) signaling pathway; Microtubule cytoskeleton regulation; Dopamine metabolism; Common pathways underlying drug addiction; Complement system; Mesodermal commitment pathway; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mesodermal commitment pathway; G protein signaling pathways; MAPK signaling pathway; Cannabinoid receptor signaling; Lipid metabolism pathway; Phosphodiesterases in neuronal function; Ras signaling; Hedgehog signaling pathway; Thermogenesis; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Vasopressin-regulated water reabsorption; GDNF signaling; Urotensin-II-mediated signaling pathway; Calcium regulation in cardiac cells; KCNQ2-related epilepsies; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway" "Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Mitochondrial protein degradation; FCGR3A-mediated IL10 synthesis; Triglyceride catabolism; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Ion homeostasis; Interleukin-3, Interleukin-5 and GM-CSF signaling; RET signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; Regulation of MECP2 expression and activity; PKA activation; PKA activation in glucagon signalling; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; CD209 (DC-SIGN) signaling; Rap1 signalling; HDL assembly; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; Loss of phosphorylation of MECP2 at T308; ROBO receptors bind AKAP5; PKA-mediated phosphorylation of key metabolic factors" "75" "0" "0.982" "1.018" "0.995" "1.030" "0.980" "0.996" "0.956" "1.019" "0.944" "162.1" "159.2" "165.1" "161.3" "167.0" "158.8" "161.4" "155.0" "165.1" "153.1" "" "" "" "" "" "" "" "" "" "" "151.9" "131.7" "153.3" "124.7" "142.3" "151.7" "147.5" "137.6" "165.1" "147.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604147819280005923" "False" "High" "IsMasterProtein" "P50613" "Cyclin-dependent kinase 7 OS=Homo sapiens OX=9606 GN=CDK7 PE=1 SV=1" "0.000" "False" "18.055" "16" "5" "6" "5" "346" "39.0" "8.47" "21.61" "5" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1022" "ENSG00000134058; ENSG00000277273" "CDK7" "hsa:1022; P50613; Q9BS60; Q9UE19" "MicroRNAs in cardiomyocyte hypertrophy; Cell cycle; Cardiac hypertrophic response; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum" "NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "43" "0" "1.020" "1.002" "1.013" "1.036" "0.996" "1.023" "1.065" "1.068" "1.039" "562.8" "573.9" "563.9" "570.2" "582.8" "560.3" "575.7" "599.5" "601.0" "584.6" "" "" "" "" "" "" "" "" "" "" "527.3" "474.9" "523.5" "440.8" "496.8" "535.3" "526.1" "532.3" "601.0" "562.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2758380383998066899" "False" "High" "IsMasterProtein" "Q86V81" "THO complex subunit 4 OS=Homo sapiens OX=9606 GN=ALYREF PE=1 SV=3" "0.000" "False" "18.050" "25" "6" "12" "6" "257" "26.9" "11.15" "34.93" "6" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf13865" "10189" "" "ALYREF" "hsa:10189; O43672; Q86V81" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway" "7" "0" "1.024" "1.062" "1.088" "1.109" "1.132" "1.126" "1.186" "1.157" "1.126" "1012.4" "1036.3" "1075.0" "1101.2" "1122.5" "1146.2" "1140.2" "1200.9" "1171.4" "1139.8" "" "" "" "" "" "" "" "" "" "" "948.6" "857.5" "998.0" "851.3" "956.8" "1095.1" "1041.9" "1066.3" "1171.4" "1097.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8311044657227682609" "False" "High" "IsMasterProtein" "Q9BZE9" "Tether containing UBX domain for GLUT4 OS=Homo sapiens OX=9606 GN=ASPSCR1 PE=1 SV=1" "0.000" "False" "18.047" "11" "5" "6" "5" "553" "60.1" "6.64" "24.41" "5" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf00789, Pf11470" "79058" "ENSG00000169696" "ASPSCR1" "A8K3K9; hsa:79058; Q7Z6N7; Q8WV59; Q96LS5; Q96M40; Q9BZE9" "" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "1" "0" "0.993" "1.007" "1.093" "1.052" "1.049" "0.991" "1.026" "1.020" "0.994" "862.5" "856.6" "868.2" "943.1" "907.1" "904.7" "854.5" "884.9" "879.6" "857.2" "" "" "" "" "" "" "" "" "" "" "808.2" "708.8" "806.0" "729.1" "773.2" "864.4" "780.8" "785.7" "879.6" "825.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6425786624467733847" "False" "High" "IsMasterProtein" "O95758" "Polypyrimidine tract-binding protein 3 OS=Homo sapiens OX=9606 GN=PTBP3 PE=1 SV=2" "0.000" "False" "18.018" "9" "6" "19" "3" "552" "59.7" "9.04" "54.21" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf11835, Pf13893" "9991" "ENSG00000119314" "PTBP3" "B1ALY2; B1ALY3; B1ALY5; B1ALY6; B3KME7; hsa:9991; O95758; Q68DB9; Q86YB3; Q86YH9" "" "" "0" "0" "0.994" "1.054" "1.128" "1.145" "1.077" "0.999" "0.970" "0.975" "1.066" "489.6" "486.6" "516.1" "552.3" "560.6" "527.4" "489.2" "474.8" "477.2" "521.8" "" "" "" "" "" "" "" "" "" "" "458.7" "402.7" "479.1" "426.9" "477.8" "503.9" "447.0" "421.6" "477.2" "502.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "280272277997118017" "False" "High" "IsMasterProtein" "Q9Y316" "Protein MEMO1 OS=Homo sapiens OX=9606 GN=MEMO1 PE=1 SV=1" "0.000" "False" "18.007" "21" "6" "6" "6" "297" "33.7" "7.14" "20.26" "6" "other biological processes" "" "" "Pf01875" "51072" "ENSG00000162959" "MEMO1" "B4DLS0; D6W575; hsa:51072; Q5R2V8; Q5R2V9; Q6NSL5; Q9Y316" "" "ERBB2 Regulates Cell Motility" "1" "0" "1.017" "1.041" "0.969" "1.020" "1.020" "0.987" "1.036" "1.020" "0.991" "770.6" "783.5" "802.3" "746.9" "786.0" "786.0" "760.7" "798.5" "785.7" "763.6" "" "" "" "" "" "" "" "" "" "" "722.0" "648.3" "744.8" "577.4" "670.0" "750.9" "695.1" "708.9" "785.7" "735.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9154000995379348407" "False" "High" "IsMasterProtein" "Q16644" "MAP kinase-activated protein kinase 3 OS=Homo sapiens OX=9606 GN=MAPKAPK3 PE=1 SV=1" "0.000" "False" "17.995" "16" "7" "9" "4" "382" "43.0" "7.28" "31.29" "7" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "7867" "ENSG00000114738" "MAPKAPK3" "B5BU67; hsa:7867; Q16644" "Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; Serotonin HTR1 group and FOS pathway" "VEGFA-VEGFR2 Pathway; Oxidative Stress Induced Senescence; p38MAPK events; activated TAK1 mediates p38 MAPK activation" "7" "0" "1.007" "0.933" "1.020" "1.004" "0.991" "0.960" "0.981" "0.977" "1.027" "770.9" "776.2" "719.5" "786.4" "774.3" "763.6" "740.4" "756.5" "753.1" "791.6" "" "" "" "" "" "" "" "" "" "" "722.3" "642.3" "668.0" "608.0" "660.0" "729.5" "676.5" "671.7" "753.1" "762.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1738440604026587204" "False" "High" "IsMasterProtein" "P60510" "Serine/threonine-protein phosphatase 4 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP4C PE=1 SV=1" "0.000" "False" "17.991" "17" "4" "8" "4" "307" "35.1" "5.06" "28.99" "4" "DNA metabolism;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00149" "5531" "ENSG00000149923" "PPP4C" "hsa:5531; P33172; P60510" "16p11.2 proximal deletion syndrome" "Processing of DNA double-strand break ends" "2" "0" "0.996" "0.958" "1.018" "1.006" "0.997" "0.935" "0.964" "0.973" "0.987" "611.8" "609.5" "586.2" "622.8" "615.4" "610.0" "572.3" "589.9" "595.5" "604.0" "" "" "" "" "" "" "" "" "" "" "573.3" "504.4" "544.2" "481.5" "524.6" "582.8" "523.0" "523.8" "595.5" "581.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "779852501093026521" "False" "High" "IsMasterProtein" "P15153" "Ras-related C3 botulinum toxin substrate 2 OS=Homo sapiens OX=9606 GN=RAC2 PE=1 SV=1" "0.000" "False" "17.990" "22" "4" "8" "1" "192" "21.4" "7.61" "30.61" "4" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00071" "5880" "ENSG00000128340" "RAC2" "hsa:5880; P15153; Q9UDJ4" "Integrin-mediated cell adhesion; RalA downstream regulated genes; B cell receptor signaling pathway; Focal adhesion; MAPK signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; Macrophage markers; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Insulin signaling; Regulation of actin cytoskeleton; Pathways in cancer; DNA damage response (only ATM dependent)" "RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; PCP/CE pathway; ROS and RNS production in phagocytes; RHO GTPases Activate NADPH Oxidases" "24" "0" "0.918" "0.954" "0.958" "1.065" "0.894" "0.907" "1.031" "1.004" "0.895" "133.7" "122.8" "127.6" "128.1" "142.5" "119.5" "121.4" "137.9" "134.3" "119.7" "" "" "" "" "" "" "" "" "" "" "125.3" "101.6" "118.4" "99.0" "121.5" "114.2" "110.9" "122.4" "134.3" "115.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5216931438576770944" "False" "High" "IsMasterProtein" "Q9UK76" "Jupiter microtubule associated homolog 1 OS=Homo sapiens OX=9606 GN=JPT1 PE=1 SV=3" "0.000" "False" "17.981" "52" "6" "13" "6" "154" "16.0" "5.60" "40.94" "6" "" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf17054" "51155" "ENSG00000189159" "JPT1" "B2R6K3; hsa:51155; Q53FG7; Q7Z2D2; Q7Z2F0; Q9UK76" "" "" "0" "0" "1.047" "0.940" "1.033" "0.980" "0.921" "0.955" "0.939" "0.998" "0.947" "1059.9" "1109.2" "996.0" "1095.2" "1038.4" "975.9" "1011.9" "995.0" "1058.1" "1003.5" "" "" "" "" "" "" "" "" "" "" "993.1" "917.8" "924.7" "846.7" "885.1" "932.4" "924.6" "883.5" "1058.1" "966.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3984777124948273039" "False" "High" "IsMasterProtein" "O94903" "Pyridoxal phosphate homeostasis protein OS=Homo sapiens OX=9606 GN=PLPBP PE=1 SV=1" "0.000" "False" "17.962" "20" "6" "10" "6" "275" "30.3" "7.50" "29.37" "6" "" "cytosol;other cell component" "other molecular function" "Pf01168" "11212" "ENSG00000147471" "PLPBP" "O94903; Q6FI94" "" "" "0" "0" "0.976" "0.930" "0.989" "0.993" "0.930" "0.993" "1.035" "0.989" "0.967" "312.0" "304.5" "290.0" "308.7" "309.7" "290.0" "309.8" "322.8" "308.5" "301.7" "" "" "" "" "" "" "" "" "" "" "292.3" "252.0" "269.3" "238.7" "264.0" "277.1" "283.0" "286.7" "308.5" "290.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "727638957837399757" "False" "High" "IsMasterProtein" "O15014" "Zinc finger protein 609 OS=Homo sapiens OX=9606 GN=ZNF609 PE=1 SV=2" "0.000" "False" "17.957" "4" "6" "7" "6" "1411" "151.1" "8.03" "18.83" "6" "other biological processes" "nucleus" "other molecular function" "" "23060" "ENSG00000180357" "ZNF609" "hsa:23060; O15014; Q0D2I2" "" "" "0" "0" "1.047" "1.027" "1.122" "1.067" "1.081" "1.151" "1.034" "1.037" "1.075" "871.6" "912.5" "894.9" "977.9" "930.4" "942.6" "1003.4" "901.1" "904.2" "936.9" "" "" "" "" "" "" "" "" "" "" "816.7" "755.1" "830.8" "756.0" "793.0" "900.5" "916.9" "800.1" "904.2" "902.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2725190465399901470" "False" "High" "IsMasterProtein" "P62829" "Large ribosomal subunit protein uL14 OS=Homo sapiens OX=9606 GN=RPL23 PE=1 SV=1" "0.000" "False" "17.956" "41" "6" "9" "6" "140" "14.9" "10.51" "28.59" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00238" "9349" "ENSG00000125691" "RPL23" "hsa:9349; P23131; P24048; P62829; Q29246; Q3SWV7; Q6P5S1" "Cytoplasmic ribosomal proteins; 17q12 copy number variation syndrome" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.063" "1.053" "1.095" "1.182" "1.174" "1.113" "1.122" "1.165" "1.113" "1321.8" "1404.9" "1391.7" "1447.6" "1562.9" "1552.4" "1471.7" "1483.6" "1540.4" "1471.5" "" "" "" "" "" "" "" "" "" "" "1238.5" "1162.6" "1292.0" "1119.0" "1332.2" "1483.2" "1344.7" "1317.3" "1540.4" "1416.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6764282473727919069" "False" "High" "IsMasterProtein" "Q96K17" "Transcription factor BTF3 homolog 4 OS=Homo sapiens OX=9606 GN=BTF3L4 PE=1 SV=1" "0.000" "False" "17.948" "44" "6" "7" "4" "158" "17.3" "6.35" "23.05" "6" "" "" "" "Pf01849" "91408" "ENSG00000134717" "BTF3L4" "B3KNJ1; D3DQ32; G3V1C6; hsa:91408; Q96K17" "" "" "0" "0" "1.107" "1.007" "1.023" "1.094" "1.026" "0.967" "0.967" "0.955" "1.002" "448.8" "496.6" "451.9" "459.2" "491.0" "460.7" "434.0" "434.0" "428.8" "449.6" "" "" "" "" "" "" "" "" "" "" "420.5" "411.0" "419.6" "355.0" "418.6" "440.1" "396.6" "385.3" "428.8" "432.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2931302988534192752" "False" "High" "IsMasterProtein" "Q53QZ3" "Rho GTPase-activating protein 15 OS=Homo sapiens OX=9606 GN=ARHGAP15 PE=1 SV=2" "0.000" "False" "17.923" "13" "6" "6" "5" "475" "54.5" "9.39" "18.06" "6" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf00169, Pf00620" "55843" "ENSG00000075884" "ARHGAP15" "hsa:55843; Q53QZ3; Q53R36; Q53RD7; Q53RT6; Q53SX9; Q584N9; Q6PJE6; Q86WP1; Q8IXX1; Q9NRL8; Q9NZ77; Q9NZ91" "Ectoderm differentiation; Ectoderm differentiation" "RAC1 GTPase cycle; RAC3 GTPase cycle" "4" "1" "0.979" "1.066" "1.046" "1.021" "1.018" "0.994" "0.996" "1.000" "1.016" "1027.6" "1006.1" "1095.3" "1074.8" "1048.9" "1046.2" "1021.4" "1023.0" "1028.0" "1043.7" "" "" "" "" "" "" "" "" "" "" "962.8" "832.6" "1016.8" "830.8" "894.0" "999.5" "933.3" "908.3" "1028.0" "1004.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4972524321603701932" "False" "High" "IsMasterProtein" "Q8IW35" "Centrosomal protein of 97 kDa OS=Homo sapiens OX=9606 GN=CEP97 PE=1 SV=1" "0.000" "False" "17.923" "5" "5" "6" "5" "865" "96.9" "5.02" "19.87" "5" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf14580" "79598" "ENSG00000182504" "CEP97" "B5MDY8; hsa:79598; Q8IW35; Q8NA71; Q9H5T9" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome" "Anchoring of the basal body to the plasma membrane; RHOV GTPase cycle" "5" "0" "1.040" "1.021" "1.062" "1.041" "1.062" "1.015" "0.916" "1.066" "1.085" "752.6" "782.3" "768.0" "799.1" "783.2" "799.2" "764.0" "689.1" "802.5" "816.2" "" "" "" "" "" "" "" "" "" "" "705.1" "647.4" "713.0" "617.7" "667.6" "763.5" "698.1" "611.9" "802.5" "785.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8205566320687520923" "False" "High" "IsMasterProtein" "Q9NSK0" "Kinesin light chain 4 OS=Homo sapiens OX=9606 GN=KLC4 PE=1 SV=3" "0.000" "False" "17.893" "11" "6" "7" "3" "619" "68.6" "6.18" "22.73" "6" "other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf13374, Pf13424" "89953" "ENSG00000137171" "KLC4" "B3KNY4; B3KPI3; B3KSQ3; B4DME9; hsa:89953; Q66K28; Q96EG6; Q9NSK0" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1" "6" "0" "0.994" "1.025" "1.025" "1.024" "0.957" "0.981" "0.953" "0.999" "1.003" "307.7" "305.9" "315.4" "315.2" "315.0" "294.6" "301.8" "293.2" "307.2" "308.7" "" "" "" "" "" "" "" "" "" "" "288.3" "253.1" "292.8" "243.7" "268.5" "281.4" "275.8" "260.3" "307.2" "297.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8139955916062878316" "False" "High" "IsMasterProtein" "Q9BZ95" "Histone-lysine N-methyltransferase NSD3 OS=Homo sapiens OX=9606 GN=NSD3 PE=1 SV=1" "0.000" "False" "17.892" "6" "7" "7" "6" "1437" "161.5" "8.21" "23.31" "7" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00855, Pf00856, Pf17907, Pf17982" "54904" "ENSG00000147548" "NSD3" "B7ZL11; D3DSX1; hsa:54904; Q1RMD3; Q3B796; Q6ZSA5; Q9BYU8; Q9BYU9; Q9BZ95; Q9H2M8; Q9H9W9; Q9NXA6" "" "PKMTs methylate histone lysines" "1" "1" "1.010" "1.004" "1.120" "1.064" "1.074" "1.143" "1.153" "1.079" "1.049" "541.6" "547.1" "544.0" "606.8" "576.4" "581.6" "618.9" "624.5" "584.3" "568.0" "" "" "" "" "" "" "" "" "" "" "507.5" "452.7" "505.0" "469.1" "491.4" "555.7" "565.5" "554.5" "584.3" "546.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8491275537287957660" "False" "High" "IsMasterProtein" "Q8NDD1" "Uncharacterized protein C1orf131 OS=Homo sapiens OX=9606 GN=C1orf131 PE=1 SV=4" "0.000" "False" "17.864" "18" "6" "7" "6" "293" "32.6" "9.88" "23.58" "6" "other biological processes" "nucleus;other cell component" "" "Pf15375" "128061" "ENSG00000143633" "C1orf131" "Q5TBI0; Q5TBI1; Q6P6B4; Q7Z6H5; Q8N432; Q8NDD1; Q96NM6" "" "" "0" "0" "1.049" "1.101" "1.062" "1.141" "1.114" "1.193" "1.277" "1.229" "1.112" "943.1" "989.2" "1038.7" "1001.4" "1076.1" "1050.8" "1125.5" "1203.9" "1159.1" "1048.5" "" "" "" "" "" "" "" "" "" "" "883.6" "818.6" "964.3" "774.2" "917.3" "1003.9" "1028.4" "1068.9" "1159.1" "1009.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8790868284272412731" "False" "High" "IsMasterProtein" "Q9UDY8" "Mucosa-associated lymphoid tissue lymphoma translocation protein 1 OS=Homo sapiens OX=9606 GN=MALT1 PE=1 SV=1" "0.000" "False" "17.826" "8" "5" "6" "5" "824" "92.2" "5.73" "20.13" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00656, Pf13895, Pf13927, Pf18703" "10892" "ENSG00000172175" "MALT1" "hsa:10892; Q9NTB7; Q9UDY8; Q9ULX4" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 22q11.2 copy number variation syndrome; Modulators of TCR signaling and T cell activation; T-cell receptor signaling pathway" "Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A/inflammasome pathway" "10" "0" "1.026" "0.999" "0.990" "1.012" "1.012" "0.966" "0.941" "0.985" "1.000" "832.4" "853.8" "831.5" "823.9" "842.5" "842.0" "803.9" "783.5" "819.6" "832.6" "" "" "" "" "" "" "" "" "" "" "780.0" "706.5" "771.9" "636.9" "718.1" "804.5" "734.5" "695.7" "819.6" "801.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5853240527723212968" "False" "High" "IsMasterProtein" "Q9H7Z7" "Prostaglandin E synthase 2 OS=Homo sapiens OX=9606 GN=PTGES2 PE=1 SV=1" "0.000" "False" "17.826" "13" "5" "6" "5" "377" "41.9" "9.16" "21.25" "5" "other metabolic processes;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf13410, Pf13417" "80142" "ENSG00000148334" "PTGES2" "hsa:80142; Q53EW9; Q5SYV6; Q96GI0; Q96GL2; Q9H7Z7" "Relationship between inflammation, COX-2 and EGFR; Omega-6-fatty acids in senescence" "Neutrophil degranulation; Synthesis of Prostaglandins (PG) and Thromboxanes (TX)" "4" "0" "0.939" "1.017" "0.934" "0.976" "1.006" "0.910" "0.985" "0.936" "1.000" "1290.2" "1211.9" "1312.5" "1204.8" "1259.0" "1297.8" "1174.7" "1270.7" "1208.0" "1290.7" "" "" "" "" "" "" "" "" "" "" "1208.9" "1002.9" "1218.4" "931.3" "1073.2" "1239.9" "1073.4" "1128.3" "1208.0" "1242.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5779447610884953183" "False" "High" "IsMasterProtein" "Q9NPD8" "Ubiquitin-conjugating enzyme E2 T OS=Homo sapiens OX=9606 GN=UBE2T PE=1 SV=1" "0.000" "False" "17.805" "39" "7" "11" "7" "197" "22.5" "7.99" "32.55" "7" "protein metabolism;DNA metabolism;other metabolic processes;stress response" "nucleus" "other molecular function" "Pf00179" "29089" "ENSG00000077152" "UBE2T" "hsa:29089; Q2TU36; Q9NPD8" "Gastric cancer network 2" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Fanconi Anemia Pathway" "3" "0" "0.930" "0.991" "1.025" "0.983" "1.012" "1.373" "0.978" "0.923" "1.001" "1218.5" "1133.3" "1207.4" "1248.5" "1198.1" "1233.1" "1673.6" "1192.3" "1124.7" "1220.1" "" "" "" "" "" "" "" "" "" "" "1141.7" "937.8" "1120.9" "965.2" "1021.2" "1178.1" "1529.2" "1058.6" "1124.7" "1174.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6609542144732775052" "False" "High" "IsMasterProtein" "Q92615" "La-related protein 4B OS=Homo sapiens OX=9606 GN=LARP4B PE=1 SV=3" "0.000" "False" "17.805" "7" "6" "9" "6" "738" "80.5" "6.92" "28.17" "6" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05383" "23185" "ENSG00000107929" "LARP4B" "A7MD20; hsa:23185; Q5T3R3; Q5T3R4; Q5T3R5; Q68CY4; Q92615" "" "" "0" "0" "0.986" "0.996" "1.071" "1.055" "1.026" "1.131" "1.148" "1.066" "0.992" "309.8" "305.4" "308.4" "331.8" "326.8" "317.9" "350.4" "355.5" "330.1" "307.3" "" "" "" "" "" "" "" "" "" "" "290.2" "252.7" "286.3" "256.5" "278.5" "303.8" "320.2" "315.7" "330.1" "295.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6622169396848351928" "False" "High" "IsMasterProtein" "Q8NFF5" "FAD synthase OS=Homo sapiens OX=9606 GN=FLAD1 PE=1 SV=1" "0.000" "False" "17.798" "10" "6" "8" "6" "587" "65.2" "6.93" "27.07" "6" "other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf00994, Pf01507" "80308" "ENSG00000160688" "FLAD1" "hsa:80308; Q8N5J1; Q8N686; Q8NFF5; Q8WU93; Q8WUJ4; Q96CR8; Q99764; Q9HBN6" "Selenium micronutrient network; Folate metabolism" "Vitamin B2 (riboflavin) metabolism" "3" "0" "0.964" "0.955" "0.968" "0.945" "0.951" "0.939" "0.941" "0.965" "0.955" "1525.6" "1470.2" "1457.6" "1476.8" "1441.8" "1450.8" "1432.2" "1435.1" "1473.0" "1456.9" "" "" "" "" "" "" "" "" "" "" "1429.5" "1216.6" "1353.2" "1141.6" "1228.9" "1386.1" "1308.6" "1274.3" "1473.0" "1402.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5875685193594640149" "False" "High" "IsMasterProtein" "Q7Z3U7" "Protein MON2 homolog OS=Homo sapiens OX=9606 GN=MON2 PE=1 SV=3" "0.000" "False" "17.786" "4" "7" "7" "7" "1717" "190.2" "6.06" "20.32" "7" "transport" "other membranes;cytosol;other cytoplasmic organelle" "" "Pf09324, Pf12783, Pf16206, Pf16213" "23041" "ENSG00000061987" "MON2" "A5D8U7; A7E2Y0; B9EGP5; F8VWA6; F8W1Z6; hsa:23041; Q7Z3U7; Q86TA2; Q8N3I5; Q8NAI0; Q8NHE2; Q9UPW1" "" "" "0" "0" "1.047" "1.008" "1.115" "1.146" "1.031" "1.057" "0.984" "1.051" "1.059" "557.0" "583.2" "561.8" "621.0" "638.1" "574.3" "589.0" "548.2" "585.5" "589.9" "" "" "" "" "" "" "" "" "" "" "521.9" "482.6" "521.5" "480.0" "543.9" "548.7" "538.2" "486.7" "585.5" "568.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7827642572833014462" "False" "High" "IsMasterProtein" "P14649" "Myosin light chain 6B OS=Homo sapiens OX=9606 GN=MYL6B PE=1 SV=1" "0.000" "False" "17.768" "28" "6" "9" "4" "208" "22.8" "5.73" "27.11" "6" "other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "" "140465" "ENSG00000196465" "MYL6B" "hsa:140465; P14649" "Ciliary landscape" "Smooth Muscle Contraction" "2" "0" "1.046" "0.949" "0.955" "0.991" "0.973" "0.937" "0.960" "0.901" "0.943" "969.0" "1013.4" "919.2" "925.1" "960.1" "942.8" "908.2" "930.0" "873.2" "913.4" "" "" "" "" "" "" "" "" "" "" "908.0" "838.6" "853.4" "715.1" "818.3" "900.7" "829.8" "825.8" "873.2" "879.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8561643854279228847" "False" "High" "IsMasterProtein" "P15927" "Replication protein A 32 kDa subunit OS=Homo sapiens OX=9606 GN=RPA2 PE=1 SV=1" "0.000" "False" "17.759" "24" "5" "12" "5" "270" "29.2" "6.15" "34.00" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08784" "6118" "ENSG00000117748" "RPA2" "hsa:6118; P15927; Q52II0; Q5TEI9; Q5TEJ5" "miRNA regulation of DNA damage response; Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair; DNA damage response" "Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Homologous Recombination (HRR); Meiotic recombination; Regulation of HSF1-mediated heat shock response; Fanconi Anemia Pathway; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "38" "0" "1.019" "1.030" "1.040" "1.040" "0.991" "0.976" "1.038" "1.057" "1.011" "1382.4" "1408.8" "1423.4" "1438.0" "1437.3" "1370.3" "1349.4" "1434.3" "1461.8" "1397.7" "" "" "" "" "" "" "" "" "" "" "1295.3" "1165.7" "1321.5" "1111.6" "1225.1" "1309.2" "1233.0" "1273.5" "1461.8" "1345.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1071096790058741915" "False" "High" "IsMasterProtein" "P46199" "Translation initiation factor IF-2, mitochondrial OS=Homo sapiens OX=9606 GN=MTIF2 PE=1 SV=2" "0.000" "False" "17.757" "9" "6" "6" "6" "727" "81.3" "7.15" "20.79" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00009, Pf11987" "4528" "ENSG00000085760" "MTIF2" "D6W5D0; hsa:4528; P46199" "" "Mitochondrial translation initiation" "1" "0" "1.019" "1.027" "1.121" "1.079" "1.069" "1.146" "0.989" "1.046" "1.075" "653.4" "665.9" "670.8" "732.5" "704.8" "698.2" "748.7" "646.2" "683.5" "702.1" "" "" "" "" "" "" "" "" "" "" "612.2" "551.0" "622.7" "566.2" "600.8" "667.1" "684.1" "573.7" "683.5" "676.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4002494153914850513" "False" "High" "IsMasterProtein" "P51665" "26S proteasome non-ATPase regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMD7 PE=1 SV=2" "0.000" "False" "17.743" "22" "5" "5" "5" "324" "37.0" "6.77" "18.53" "5" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01398, Pf13012" "5713" "ENSG00000103035" "PSMD7" "D3DWS9; hsa:5713; P51665; Q6PKI2; Q96E97" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Neutrophil degranulation; Downstream TCR signaling; Regulation of expression of SLITs and ROBOs; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "0.928" "0.921" "1.020" "1.017" "1.035" "0.935" "0.976" "0.974" "1.035" "446.1" "414.1" "410.9" "454.9" "453.8" "461.6" "417.2" "435.6" "434.7" "461.7" "" "" "" "" "" "" "" "" "" "" "418.0" "342.7" "381.4" "351.7" "386.8" "441.0" "381.3" "386.8" "434.7" "444.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8857038607970442570" "False" "High" "IsMasterProtein" "Q16836" "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HADH PE=1 SV=3" "0.000" "False" "17.732" "17" "8" "11" "8" "314" "34.3" "8.85" "27.54" "8" "other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00725, Pf02737" "3033" "ENSG00000138796" "HADH" "hsa:3033; J3KQ17; O00324; O00397; O00753; Q16836; Q4W5B4" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; Amino acid metabolism; IL-18 signaling pathway; Mitochondrial fatty acid oxidation disorders" "Mitochondrial protein degradation; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA" "12" "0" "1.380" "1.076" "1.090" "1.200" "1.002" "0.947" "1.086" "1.296" "1.098" "690.7" "952.9" "743.1" "753.1" "828.7" "692.1" "654.1" "750.2" "895.1" "758.4" "" "" "" "" "" "" "" "" "" "" "647.2" "788.5" "689.9" "582.1" "706.4" "661.3" "597.7" "666.1" "895.1" "730.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5912099457443708123" "False" "High" "IsMasterProtein" "O43913" "Origin recognition complex subunit 5 OS=Homo sapiens OX=9606 GN=ORC5 PE=1 SV=1" "0.000" "False" "17.731" "15" "8" "8" "8" "435" "50.3" "7.74" "21.18" "8" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13191, Pf14630, Pf21639" "5001" "ENSG00000164815" "ORC5" "A4D0P8; hsa:5001; O43913; O60590; O95268" "Cell cycle; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication; CDC6 association with the ORC:origin complex" "10" "0" "0.994" "1.053" "0.965" "0.986" "1.023" "0.947" "0.994" "1.071" "1.035" "707.2" "703.0" "744.6" "682.5" "697.3" "723.5" "670.0" "703.1" "757.6" "731.9" "" "" "" "" "" "" "" "" "" "" "662.6" "581.7" "691.3" "527.6" "594.3" "691.2" "612.2" "624.3" "757.6" "704.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "680199301258843894" "False" "High" "IsMasterProtein" "O95229" "ZW10 interactor OS=Homo sapiens OX=9606 GN=ZWINT PE=1 SV=2" "0.000" "False" "17.730" "25" "7" "9" "7" "277" "31.3" "5.15" "21.70" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf15556" "11130" "ENSG00000122952" "ZWINT" "A6NNV6; hsa:11130; O95229; Q0D2I3; Q9BWD0" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.055" "0.955" "1.100" "1.046" "1.078" "1.007" "1.205" "0.950" "1.269" "641.7" "677.1" "612.6" "705.8" "671.1" "691.4" "646.3" "773.3" "609.6" "814.4" "" "" "" "" "" "" "" "" "" "" "601.2" "560.3" "568.7" "545.6" "572.1" "660.6" "590.5" "686.6" "609.6" "784.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1095568573092082412" "False" "High" "IsMasterProtein" "Q16762" "Thiosulfate sulfurtransferase OS=Homo sapiens OX=9606 GN=TST PE=1 SV=4" "0.000" "False" "17.720" "26" "6" "9" "6" "297" "33.4" "7.25" "25.82" "6" "other metabolic processes;transport;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00581" "7263" "ENSG00000128311" "TST" "B3KRM1; hsa:7263; Q16762; Q6IB06" "" "Sulfide oxidation to sulfate" "2" "0" "1.072" "1.022" "1.124" "1.157" "1.152" "1.207" "1.166" "1.128" "1.261" "198.9" "213.2" "203.3" "223.6" "230.1" "229.0" "240.0" "231.8" "224.4" "250.7" "" "" "" "" "" "" "" "" "" "" "186.3" "176.4" "188.8" "172.8" "196.1" "218.8" "219.3" "205.8" "224.4" "241.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4014732936272449079" "False" "High" "IsMasterProtein" "Q53EL6" "Programmed cell death protein 4 OS=Homo sapiens OX=9606 GN=PDCD4 PE=1 SV=2" "0.000" "False" "17.701" "12" "5" "7" "5" "469" "51.7" "5.21" "21.47" "5" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02847" "27250" "ENSG00000150593" "PDCD4" "B2RCV4; B5ME91; hsa:27250; O15501; Q53EL6; Q5VZS6; Q6PJI5; Q8TAR5; Q99834" "Translation inhibitors in chronically activated PDGFRA cells; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "4" "0" "1.061" "1.130" "1.031" "1.011" "1.094" "1.048" "1.132" "1.184" "1.127" "292.5" "310.2" "330.5" "301.6" "295.7" "320.1" "306.5" "331.1" "346.3" "329.6" "" "" "" "" "" "" "" "" "" "" "274.0" "256.7" "306.8" "233.2" "252.0" "305.8" "280.0" "294.0" "346.3" "317.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1130211750852848646" "False" "High" "IsMasterProtein" "Q13404" "Ubiquitin-conjugating enzyme E2 variant 1 OS=Homo sapiens OX=9606 GN=UBE2V1 PE=1 SV=2" "0.000" "False" "17.700" "49" "7" "13" "2" "147" "16.5" "7.93" "42.11" "7" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00179" "387522; 7335" "ENSG00000244687" "UBE2V1" "E1P629; hsa:387522; hsa:7335; Q13403; Q13404; Q13532; Q5TGE0; Q5TGE3; Q96H34; Q9GZT0; Q9GZW1; Q9H4J3; Q9H4J4; Q9UKL1; Q9UM48; Q9UM49; Q9UM50" "IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Aggrephagy; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "19" "0" "1.109" "1.034" "0.985" "1.033" "1.007" "0.966" "1.060" "0.988" "1.025" "506.5" "561.8" "523.9" "498.9" "523.0" "509.9" "489.3" "536.9" "500.4" "519.1" "" "" "" "" "" "" "" "" "" "" "474.6" "464.9" "486.4" "385.7" "445.8" "487.2" "447.1" "476.7" "500.4" "499.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8719545438223687688" "False" "High" "IsMasterProtein" "Q9NWV8" "BRISC and BRCA1-A complex member 1 OS=Homo sapiens OX=9606 GN=BABAM1 PE=1 SV=1" "0.000" "False" "17.675" "19" "5" "6" "5" "329" "36.5" "4.64" "24.65" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "" "29086" "ENSG00000105393" "BABAM1" "A8MQT0; B4DRY9; B4DVR1; hsa:29086; Q6FIA0; Q9NWV8; Q9P018" "5q35 copy number variation" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "6" "0" "1.008" "0.993" "0.906" "0.995" "0.974" "0.999" "0.935" "0.958" "0.975" "607.6" "612.7" "603.2" "550.4" "604.4" "591.7" "606.8" "568.1" "582.2" "592.5" "" "" "" "" "" "" "" "" "" "" "569.3" "507.0" "560.0" "425.5" "515.2" "565.3" "554.4" "504.4" "582.2" "570.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9193943049168300683" "False" "High" "IsMasterProtein" "Q02818" "Nucleobindin-1 OS=Homo sapiens OX=9606 GN=NUCB1 PE=1 SV=4" "0.000" "False" "17.662" "12" "6" "6" "6" "461" "53.8" "5.25" "20.80" "6" "signal transduction" "ER/Golgi" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "" "4924" "ENSG00000104805" "NUCB1" "B2RD64; hsa:4924; Q02818; Q15838; Q7Z4J7; Q9BUR1" "" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "2" "0" "1.069" "1.015" "1.077" "1.068" "1.006" "1.034" "1.068" "1.036" "1.052" "467.6" "499.8" "474.4" "503.7" "499.4" "470.5" "483.5" "499.6" "484.5" "492.1" "" "" "" "" "" "" "" "" "" "" "438.1" "413.6" "440.4" "389.4" "425.7" "449.5" "441.8" "443.6" "484.5" "473.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4393204020125526762" "False" "High" "IsMasterProtein" "O75164" "Lysine-specific demethylase 4A OS=Homo sapiens OX=9606 GN=KDM4A PE=1 SV=2" "0.000" "False" "17.657" "5" "6" "8" "6" "1064" "120.6" "5.85" "23.04" "6" "cell organization and biogenesis;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02373, Pf02375, Pf13831, Pf13832, Pf18104" "9682" "ENSG00000066135" "KDM4A" "hsa:9682; O75164; Q5VVB1" "" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" "3" "0" "1.071" "1.037" "1.141" "1.099" "1.113" "1.109" "0.997" "1.037" "1.052" "246.7" "264.1" "255.7" "281.4" "271.2" "274.5" "273.6" "246.0" "255.9" "259.5" "" "" "" "" "" "" "" "" "" "" "231.1" "218.5" "237.4" "217.5" "231.1" "262.3" "250.0" "218.4" "255.9" "249.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9146278248105171304" "False" "High" "IsMasterProtein" "Q6SJ93" "Serine protease FAM111B OS=Homo sapiens OX=9606 GN=FAM111B PE=1 SV=1" "0.000" "False" "17.640" "8" "7" "9" "6" "734" "84.6" "8.59" "29.14" "7" "protein metabolism;DNA metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf13365" "374393" "ENSG00000189057" "FAM111B" "B4E2G2; hsa:374393; Q6P661; Q6SJ93" "" "" "0" "0" "0.969" "1.003" "0.919" "0.948" "0.954" "0.794" "0.810" "0.800" "0.946" "1683.9" "1631.8" "1688.8" "1547.8" "1595.8" "1606.9" "1337.1" "1364.6" "1347.0" "1593.8" "" "" "" "" "" "" "" "" "" "" "1577.8" "1350.3" "1567.8" "1196.5" "1360.2" "1535.2" "1221.8" "1211.6" "1347.0" "1534.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9004188409903141881" "False" "High" "IsMasterProtein" "P52758" "2-iminobutanoate/2-iminopropanoate deaminase OS=Homo sapiens OX=9606 GN=RIDA PE=1 SV=1" "0.000" "False" "17.625" "27" "3" "6" "3" "137" "14.5" "8.68" "22.90" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01042" "10247" "ENSG00000132541" "RIDA" "hsa:10247; P52758; Q6FHU9; Q6IBG0" "" "Threonine catabolism" "1" "0" "1.047" "1.002" "1.045" "1.068" "1.075" "1.017" "1.061" "1.022" "1.008" "841.4" "881.3" "843.2" "879.5" "898.8" "904.8" "855.5" "893.1" "859.8" "848.5" "" "" "" "" "" "" "" "" "" "" "788.4" "729.3" "782.8" "679.9" "766.1" "864.4" "781.7" "793.0" "859.8" "817.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7568231581715943755" "False" "High" "IsMasterProtein" "Q7Z333" "Probable helicase senataxin OS=Homo sapiens OX=9606 GN=SETX PE=1 SV=4" "0.000" "False" "17.619" "2" "6" "7" "6" "2677" "302.7" "7.17" "21.28" "6" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13086, Pf13087" "23064" "ENSG00000107290" "SETX" "A2A396; B2RPB2; B5ME16; C9JQ10; hsa:23064; O75120; Q3KQX4; Q5JUJ1; Q68DW5; Q6AZD7; Q7Z333; Q7Z3J6; Q8WX33; Q9H9D1; Q9NVP9" "Interactome of polycomb repressive complex 2 (PRC2)" "" "1" "0" "1.103" "1.068" "1.066" "1.121" "1.075" "1.055" "0.954" "0.965" "1.111" "268.2" "295.8" "286.5" "286.0" "300.6" "288.2" "283.0" "256.0" "258.8" "298.0" "" "" "" "" "" "" "" "" "" "" "251.3" "244.8" "265.9" "221.1" "256.3" "275.3" "258.6" "227.3" "258.8" "286.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9007113237130658680" "False" "High" "IsMasterProtein" "O15498" "Synaptobrevin homolog YKT6 OS=Homo sapiens OX=9606 GN=YKT6 PE=1 SV=1" "0.000" "False" "17.608" "29" "6" "11" "6" "198" "22.4" "6.92" "35.39" "6" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957, Pf13774" "10652" "ENSG00000106636" "YKT6" "B4DR94; hsa:10652; O15498; Q53F01; Q6FGU9; Q6IB15" "" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; COPI-mediated anterograde transport; RAC3 GTPase cycle; Intra-Golgi traffic; COPII-mediated vesicle transport" "8" "0" "0.975" "0.960" "0.910" "0.931" "0.944" "0.915" "0.937" "0.894" "0.933" "1913.5" "1866.4" "1836.1" "1741.0" "1781.6" "1806.6" "1751.1" "1793.1" "1710.2" "1784.8" "" "" "" "" "" "" "" "" "" "" "1792.9" "1544.5" "1704.6" "1345.9" "1518.6" "1726.0" "1600.0" "1592.1" "1710.2" "1718.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1042758646776431623" "False" "High" "IsMasterProtein" "Q9UQR0" "Sex comb on midleg-like protein 2 OS=Homo sapiens OX=9606 GN=SCML2 PE=1 SV=1" "0.000" "False" "17.608" "9" "5" "8" "5" "700" "77.2" "8.54" "23.15" "5" "other biological processes" "nucleus" "other molecular function" "Pf00536, Pf02820, Pf12140, Pf17208" "10389" "ENSG00000102098" "SCML2" "hsa:10389; Q5JXE6; Q86U98; Q8IWD0; Q8NDP2; Q9UGC5; Q9UQR0" "" "" "0" "0" "1.115" "1.053" "1.135" "1.112" "1.117" "1.138" "1.112" "1.148" "1.083" "384.9" "429.0" "405.3" "436.9" "427.9" "429.8" "438.0" "427.9" "441.8" "416.9" "" "" "" "" "" "" "" "" "" "" "360.6" "355.0" "376.3" "337.7" "364.8" "410.6" "400.2" "379.9" "441.8" "401.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5470294891726501754" "False" "High" "IsMasterProtein" "P61962" "DDB1- and CUL4-associated factor 7 OS=Homo sapiens OX=9606 GN=DCAF7 PE=1 SV=1" "0.000" "False" "17.588" "21" "7" "8" "7" "342" "38.9" "5.52" "17.26" "7" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "10238" "ENSG00000136485" "DCAF7" "B4E039; D3DU14; hsa:10238; O15491; P61962; Q9DAE4" "Ciliary landscape; DYRK1A involvement regarding cell proliferation in brain development" "Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "4" "0" "1.007" "1.086" "1.053" "1.071" "1.095" "1.026" "1.030" "1.067" "1.089" "935.5" "942.3" "1016.2" "984.6" "1002.3" "1024.0" "959.6" "963.5" "998.6" "1019.0" "" "" "" "" "" "" "" "" "" "" "876.5" "779.7" "943.4" "761.2" "854.3" "978.3" "876.8" "855.5" "998.6" "981.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7441805136985848157" "False" "High" "IsMasterProtein" "Q8TB52" "F-box only protein 30 OS=Homo sapiens OX=9606 GN=FBXO30 PE=1 SV=3" "0.000" "False" "17.588" "9" "5" "6" "5" "745" "82.3" "5.40" "21.31" "5" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf15965, Pf15966" "84085" "ENSG00000118496" "FBXO30" "hsa:84085; Q8TB52; Q9BXZ7" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "0.962" "0.935" "0.900" "0.964" "0.983" "0.896" "0.908" "0.954" "1.021" "1107.9" "1066.0" "1036.4" "996.9" "1068.0" "1088.6" "992.5" "1005.8" "1056.7" "1131.6" "" "" "" "" "" "" "" "" "" "" "1038.1" "882.1" "962.2" "770.7" "910.3" "1040.0" "906.9" "893.0" "1056.7" "1089.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2222501069186758979" "False" "High" "IsMasterProtein" "Q86W42" "THO complex subunit 6 homolog OS=Homo sapiens OX=9606 GN=THOC6 PE=1 SV=1" "0.000" "False" "17.565" "21" "6" "8" "6" "341" "37.5" "7.43" "28.91" "6" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00400" "79228" "ENSG00000131652" "THOC6" "B2RA85; hsa:79228; Q86W42; Q8NBR1; Q9BTV9" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "3" "0" "1.021" "1.062" "1.197" "1.186" "1.092" "1.195" "1.214" "1.234" "1.146" "295.9" "302.0" "314.1" "354.1" "350.9" "323.0" "353.6" "359.3" "365.0" "339.2" "" "" "" "" "" "" "" "" "" "" "277.2" "249.9" "291.6" "273.7" "299.1" "308.6" "323.1" "319.0" "365.0" "326.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1587907933929237870" "False" "High" "IsMasterProtein" "Q02548" "Paired box protein Pax-5 OS=Homo sapiens OX=9606 GN=PAX5 PE=1 SV=1" "0.000" "False" "17.564" "16" "4" "5" "3" "391" "42.1" "9.00" "20.84" "4" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00292, Pf12403" "5079" "ENSG00000196092" "PAX5" "A3QVP6; A3QVP7; A3QVP8; C0KTF6; C0KTF7; C0KTF8; C0KTF9; C0KTG0; hsa:5079; O75933; Q02548; Q5SFM2; Q6S728; Q6S729; Q6S730; Q6S731; Q6S732" "Prion disease pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; ID signaling pathway" "RUNX1 regulates transcription of genes involved in BCR signaling" "4" "1" "1.066" "1.003" "1.133" "1.119" "1.011" "1.049" "0.993" "0.999" "1.010" "441.6" "470.7" "442.9" "500.3" "494.4" "446.4" "463.3" "438.6" "441.3" "446.0" "" "" "" "" "" "" "" "" "" "" "413.8" "389.5" "411.2" "386.8" "421.4" "426.4" "423.3" "389.5" "441.3" "429.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5616510837335031809" "False" "High" "IsMasterProtein" "P15586" "N-acetylglucosamine-6-sulfatase OS=Homo sapiens OX=9606 GN=GNS PE=1 SV=3" "0.000" "False" "17.478" "9" "5" "5" "5" "552" "62.0" "8.31" "18.78" "5" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00884" "2799" "ENSG00000135677" "GNS" "B4DYH8; hsa:2799; P15586; Q53F05" "Glycosaminoglycan degradation" "Neutrophil degranulation; Lysosome Vesicle Biogenesis; Keratan sulfate degradation; MPS IIID - Sanfilippo syndrome D" "5" "0" "1.093" "0.964" "0.879" "1.003" "1.113" "0.942" "1.024" "1.040" "1.035" "184.6" "201.8" "178.1" "162.3" "185.2" "205.6" "173.9" "189.1" "192.1" "191.0" "" "" "" "" "" "" "" "" "" "" "173.0" "167.0" "165.3" "125.5" "157.9" "196.4" "158.9" "167.9" "192.1" "183.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5102394332226681343" "False" "High" "IsMasterProtein" "Q05932" "Folylpolyglutamate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=FPGS PE=1 SV=3" "0.000" "False" "17.461" "12" "6" "8" "6" "587" "64.6" "7.94" "24.76" "6" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "" "2356" "ENSG00000136877" "FPGS" "B3KPW4; B7Z2Z3; F5H0K6; hsa:2356; Q05932; Q5JU19; Q5JU22; Q6P2P6" "Fluoropyrimidine activity" "" "1" "0" "0.937" "0.946" "0.955" "0.944" "0.974" "0.875" "0.836" "0.812" "0.946" "1099.2" "1029.4" "1040.3" "1049.9" "1037.3" "1070.3" "961.3" "918.7" "892.7" "1039.3" "" "" "" "" "" "" "" "" "" "" "1029.9" "851.8" "965.8" "811.6" "884.2" "1022.5" "878.4" "815.7" "892.7" "1000.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5965687288212214297" "False" "High" "IsMasterProtein" "Q7L2H7" "Eukaryotic translation initiation factor 3 subunit M OS=Homo sapiens OX=9606 GN=EIF3M PE=1 SV=1" "0.000" "False" "17.451" "22" "6" "10" "6" "374" "42.5" "5.63" "36.30" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01399, Pf18005" "10480" "ENSG00000149100" "EIF3M" "A8K7X4; B4E2Q4; hsa:10480; O60735; Q2F836; Q53HL6; Q7L2H7; Q9BXW1" "" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "6" "0" "1.703" "1.013" "1.266" "1.280" "1.251" "1.183" "1.040" "1.295" "1.125" "439.1" "747.5" "444.9" "556.0" "562.0" "549.3" "519.5" "456.6" "568.7" "494.2" "" "" "" "" "" "" "" "" "" "" "411.4" "618.6" "413.0" "429.8" "479.0" "524.8" "474.7" "405.4" "568.7" "475.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5706954355209209913" "False" "High" "IsMasterProtein" "Q99436" "Proteasome subunit beta type-7 OS=Homo sapiens OX=9606 GN=PSMB7 PE=1 SV=1" "0.000" "False" "17.449" "21" "5" "9" "5" "277" "29.9" "7.68" "27.35" "5" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf12465" "5695" "ENSG00000136930" "PSMB7" "B4E0P1; hsa:5695; Q5TBG6; Q96AG8; Q99436; Q9BWA7" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "ER-Phagosome pathway; Neutrophil degranulation; Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Hedgehog 'on' state; Antigen processing: Ubiquitination & Proteasome degradation; UCH proteinases; Neddylation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "0.948" "0.962" "0.968" "0.911" "0.944" "0.888" "0.947" "0.952" "0.924" "4189.7" "3971.9" "4031.7" "4055.9" "3816.3" "3957.0" "3720.2" "3969.0" "3987.2" "3873.3" "" "" "" "" "" "" "" "" "" "" "3925.7" "3286.7" "3743.0" "3135.4" "3252.9" "3780.6" "3399.3" "3524.1" "3987.2" "3729.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "636260914267966179" "False" "High" "IsMasterProtein" "Q6YP21" "Kynurenine--oxoglutarate transaminase 3 OS=Homo sapiens OX=9606 GN=KYAT3 PE=1 SV=1" "0.000" "False" "17.448" "14" "6" "6" "6" "454" "51.4" "8.19" "18.41" "6" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00155" "56267" "ENSG00000137944" "KYAT3" "B3KQ13; hsa:56267; O95335; Q5JS27; Q5T9T7; Q5T9T8; Q6AI27; Q6ICW1; Q6YP21; Q9BVY5" "Tryptophan metabolism" "Tryptophan catabolism" "2" "0" "0.957" "1.033" "0.931" "0.986" "1.002" "0.922" "0.984" "0.966" "0.956" "1565.8" "1498.7" "1616.8" "1457.1" "1544.5" "1568.9" "1444.3" "1540.2" "1512.1" "1496.9" "" "" "" "" "" "" "" "" "" "" "1467.1" "1240.1" "1501.0" "1126.4" "1316.5" "1499.0" "1319.7" "1367.6" "1512.1" "1441.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7556916282893625233" "False" "High" "IsMasterProtein" "O15347" "High mobility group protein B3 OS=Homo sapiens OX=9606 GN=HMGB3 PE=1 SV=4" "0.000" "False" "17.446" "24" "5" "6" "4" "200" "23.0" "8.37" "20.54" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00505, Pf09011" "3149" "ENSG00000029993" "HMGB3" "hsa:3149; O15347; O95556; Q6NS40" "" "" "0" "0" "1.130" "1.101" "1.085" "1.130" "1.043" "1.154" "1.179" "1.092" "1.098" "377.9" "427.0" "415.9" "410.0" "426.9" "394.2" "436.2" "445.5" "412.5" "414.8" "" "" "" "" "" "" "" "" "" "" "354.1" "353.3" "386.1" "317.0" "363.9" "376.6" "398.5" "395.6" "412.5" "399.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3899808669823360054" "False" "High" "IsMasterProtein" "Q9Y2U8" "Inner nuclear membrane protein Man1 OS=Homo sapiens OX=9606 GN=LEMD3 PE=1 SV=2" "0.000" "False" "17.431" "10" "6" "6" "6" "911" "99.9" "7.55" "24.03" "6" "other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf03020, Pf09402" "23592" "ENSG00000174106" "LEMD3" "hsa:23592; Q9NT47; Q9NYA5; Q9Y2U8" "Envelope proteins and their potential roles in EDMD physiopathology" "RAC1 GTPase cycle; RAC3 GTPase cycle; RND2 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina" "12" "0" "0.952" "0.959" "1.046" "1.007" "1.003" "1.037" "1.013" "0.960" "0.942" "553.4" "526.7" "530.8" "578.8" "557.4" "555.0" "573.9" "560.5" "531.4" "521.5" "" "" "" "" "" "" "" "" "" "" "518.5" "435.8" "492.8" "447.5" "475.1" "530.2" "524.4" "497.7" "531.4" "502.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4990507016878311040" "False" "High" "IsMasterProtein" "P42126" "Enoyl-CoA delta isomerase 1, mitochondrial OS=Homo sapiens OX=9606 GN=ECI1 PE=1 SV=1" "0.000" "False" "17.426" "19" "5" "11" "5" "302" "32.8" "8.54" "31.49" "5" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00378" "1632" "ENSG00000167969" "ECI1" "A8K512; hsa:1632; P42126; Q13290; Q7Z2L6; Q7Z2L7; Q9BUB8; Q9BW05; Q9UDG6" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Mitochondrial fatty acid oxidation disorders" "Mitochondrial protein degradation; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" "5" "0" "0.988" "1.096" "1.093" "1.080" "1.037" "1.037" "1.066" "1.100" "1.075" "654.9" "647.2" "717.7" "715.7" "707.3" "679.0" "679.2" "698.0" "720.4" "704.1" "" "" "" "" "" "" "" "" "" "" "613.7" "535.5" "666.3" "553.3" "602.9" "648.7" "620.6" "619.8" "720.4" "678.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3276719871576654886" "False" "High" "IsMasterProtein" "Q92917" "G-patch domain and KOW motifs-containing protein OS=Homo sapiens OX=9606 GN=GPKOW PE=1 SV=2" "0.000" "False" "17.425" "14" "6" "6" "6" "476" "52.2" "6.15" "23.09" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00467, Pf12656" "27238" "ENSG00000068394; ENSG00000292204" "GPKOW" "hsa:27238; Q59EK5; Q92917; Q9BQA8" "" "mRNA Splicing - Major Pathway" "1" "0" "0.937" "1.003" "0.904" "0.943" "1.008" "0.949" "1.021" "1.060" "0.975" "1100.4" "1031.1" "1103.2" "994.6" "1037.9" "1108.7" "1044.5" "1123.0" "1166.9" "1073.1" "" "" "" "" "" "" "" "" "" "" "1031.0" "853.2" "1024.1" "768.9" "884.7" "1059.3" "954.4" "997.1" "1166.9" "1033.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2093622572460603588" "False" "High" "IsMasterProtein" "Q8NBF6" "Late secretory pathway protein AVL9 homolog OS=Homo sapiens OX=9606 GN=AVL9 PE=1 SV=1" "0.000" "False" "17.414" "9" "6" "9" "6" "648" "71.9" "6.21" "27.93" "6" "other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf09794" "23080" "ENSG00000105778" "AVL9" "hsa:23080; Q8NBF6; Q92573" "" "" "0" "0" "0.986" "1.020" "1.008" "1.030" "0.965" "1.025" "0.956" "1.005" "1.026" "953.1" "939.8" "972.5" "960.4" "982.0" "919.8" "977.2" "910.9" "957.9" "978.0" "" "" "" "" "" "" "" "" "" "" "893.0" "777.7" "902.8" "742.5" "837.0" "878.8" "892.9" "808.8" "957.9" "941.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491250249564736583" "False" "High" "IsMasterProtein" "P49902" "Cytosolic purine 5'-nucleotidase OS=Homo sapiens OX=9606 GN=NT5C2 PE=1 SV=1" "0.000" "False" "17.414" "11" "7" "8" "7" "561" "64.9" "6.14" "24.35" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf05761" "22978" "ENSG00000076685" "NT5C2" "B7Z382; D3DR91; hsa:22978; P49902; Q5JUV5" "" "Purine catabolism; Ribavirin ADME; Abacavir metabolism" "3" "0" "0.996" "1.008" "0.952" "0.933" "0.977" "0.955" "0.994" "0.943" "0.947" "1484.6" "1478.8" "1497.0" "1414.0" "1385.2" "1451.0" "1417.1" "1475.5" "1400.3" "1406.3" "" "" "" "" "" "" "" "" "" "" "1391.1" "1223.7" "1389.8" "1093.0" "1180.7" "1386.3" "1294.9" "1310.1" "1400.3" "1354.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "456544607600152383" "False" "High" "IsMasterProtein" "Q9UJY5" "ADP-ribosylation factor-binding protein GGA1 OS=Homo sapiens OX=9606 GN=GGA1 PE=1 SV=1" "0.000" "False" "17.387" "10" "9" "11" "8" "639" "70.3" "5.29" "24.64" "9" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "26088" "ENSG00000100083" "GGA1" "A8K3D3; B0QYR7; hsa:26088; Q5R3N1; Q5TG07; Q6IC75; Q86YA9; Q8NCS6; Q9BW94; Q9UG00; Q9UGW0; Q9UGW1; Q9UJY5" "" "TBC/RABGAPs; Amyloid fiber formation" "2" "0" "0.915" "1.044" "0.981" "1.037" "1.056" "0.996" "1.071" "0.927" "1.009" "794.2" "726.7" "828.9" "779.2" "823.5" "838.4" "790.8" "850.5" "736.6" "801.0" "" "" "" "" "" "" "" "" "" "" "744.2" "601.3" "769.5" "602.3" "701.9" "801.0" "722.5" "755.1" "736.6" "771.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5080369595642031285" "False" "High" "IsMasterProtein" "Q9BVG4" "Protein PBDC1 OS=Homo sapiens OX=9606 GN=PBDC1 PE=1 SV=1" "0.000" "False" "17.383" "28" "6" "8" "6" "233" "26.0" "4.79" "24.28" "6" "" "" "" "Pf04669" "51260" "ENSG00000102390" "PBDC1" "hsa:51260; Q9BVG4" "" "" "0" "0" "1.201" "1.160" "1.033" "1.060" "0.949" "0.797" "1.061" "1.089" "0.998" "171.6" "206.1" "199.0" "177.2" "181.9" "162.9" "136.7" "182.0" "186.9" "171.2" "" "" "" "" "" "" "" "" "" "" "160.8" "170.5" "184.7" "137.0" "155.0" "155.6" "124.9" "161.6" "186.9" "164.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1344142120960836563" "False" "High" "IsMasterProtein" "Q9BWS9" "Chitinase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHID1 PE=1 SV=1" "0.000" "False" "17.380" "14" "6" "8" "6" "393" "44.9" "8.63" "19.70" "6" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00704" "66005" "ENSG00000177830" "CHID1" "B3KWB0; hsa:66005; Q8NBM9; Q96CZ3; Q96S93; Q96SK0; Q9BWS9; Q9BY52" "" "Platelet degranulation" "1" "0" "1.144" "1.014" "1.029" "1.102" "1.205" "1.070" "1.170" "1.238" "1.137" "401.9" "459.9" "407.5" "413.6" "442.9" "484.1" "430.1" "470.2" "497.7" "456.7" "" "" "" "" "" "" "" "" "" "" "376.5" "380.6" "378.3" "319.7" "377.5" "462.5" "393.0" "417.5" "497.7" "439.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4850932002920581345" "False" "High" "IsMasterProtein" "Q96GX5" "Serine/threonine-protein kinase greatwall OS=Homo sapiens OX=9606 GN=MASTL PE=1 SV=1" "0.000" "False" "17.373" "7" "6" "9" "5" "879" "97.3" "5.99" "18.94" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "84930" "ENSG00000120539" "MASTL" "hsa:84930; Q5T8D5; Q5T8D7; Q8NCD6; Q96GX5; Q96SJ5" "" "MASTL Facilitates Mitotic Progression" "1" "0" "0.867" "0.861" "1.023" "0.859" "0.820" "0.917" "0.879" "0.869" "0.816" "80.0" "69.4" "68.9" "81.8" "68.7" "65.6" "73.4" "70.3" "69.5" "65.3" "" "" "" "" "" "" "" "" "" "" "75.0" "57.4" "64.0" "63.3" "58.6" "62.7" "67.0" "62.4" "69.5" "62.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3174171264893505362" "False" "High" "IsMasterProtein" "Q9H2J4" "Phosducin-like protein 3 OS=Homo sapiens OX=9606 GN=PDCL3 PE=1 SV=1" "0.000" "False" "17.366" "23" "5" "8" "5" "239" "27.6" "4.84" "24.40" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02114" "79031" "ENSG00000115539" "PDCL3" "B2RA00; hsa:79031; Q53S68; Q9H2J4" "" "" "0" "0" "0.963" "0.921" "0.960" "0.955" "1.003" "0.939" "0.980" "0.955" "0.968" "1300.4" "1251.7" "1197.9" "1248.8" "1242.3" "1304.8" "1221.4" "1274.4" "1242.4" "1258.8" "" "" "" "" "" "" "" "" "" "" "1218.5" "1035.8" "1112.1" "965.4" "1058.9" "1246.6" "1116.1" "1131.6" "1242.4" "1212.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8788472230308956" "False" "High" "IsMasterProtein" "Q8NCW5" "NAD(P)H-hydrate epimerase OS=Homo sapiens OX=9606 GN=NAXE PE=1 SV=2" "0.000" "False" "17.359" "22" "6" "13" "6" "288" "31.7" "7.66" "30.47" "6" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;mitochondrion;other cell component" "other molecular function" "Pf03853" "128240" "ENSG00000163382" "NAXE" "B4DGY3; hsa:128240; Q496C6; Q5T3I2; Q8NCW5" "" "Nicotinamide salvaging" "1" "0" "1.062" "1.055" "1.007" "1.029" "1.028" "0.988" "1.013" "1.047" "1.004" "477.4" "506.8" "503.4" "480.7" "491.2" "490.9" "471.8" "483.5" "500.0" "479.1" "" "" "" "" "" "" "" "" "" "" "447.3" "419.4" "467.3" "371.6" "418.7" "469.0" "431.1" "429.3" "500.0" "461.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3546401136209877532" "False" "High" "IsMasterProtein" "O75821" "Eukaryotic translation initiation factor 3 subunit G OS=Homo sapiens OX=9606 GN=EIF3G PE=1 SV=2" "0.000" "False" "17.359" "19" "6" "9" "6" "320" "35.6" "6.13" "30.57" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00076, Pf12353" "8666" "ENSG00000130811" "EIF3G" "hsa:8666; O14801; O75821; Q969U5" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "0.966" "0.960" "0.947" "0.947" "0.932" "1.097" "1.166" "1.029" "1.019" "1964.2" "1898.2" "1885.3" "1860.4" "1860.9" "1830.1" "2154.6" "2290.5" "2021.3" "2002.4" "" "" "" "" "" "" "" "" "" "" "1840.5" "1570.7" "1750.2" "1438.1" "1586.1" "1748.5" "1968.7" "2033.7" "2021.3" "1928.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3673508278002205446" "False" "High" "IsMasterProtein" "P36542" "ATP synthase subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1C PE=1 SV=1" "0.000" "False" "17.358" "16" "5" "7" "5" "298" "33.0" "9.22" "19.73" "5" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf00231" "509" "ENSG00000165629" "ATP5F1C" "A8KA31; hsa:509; P36542; Q5VYP3; Q6I9V2; Q96AS8" "Electron transport chain: OXPHOS system in mitochondria" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "4" "0" "1.081" "0.961" "0.942" "0.889" "0.907" "0.943" "0.741" "0.794" "0.953" "561.0" "606.3" "539.1" "528.6" "498.7" "509.0" "529.3" "415.9" "445.2" "534.5" "" "" "" "" "" "" "" "" "" "" "525.7" "501.7" "500.5" "408.7" "425.0" "486.3" "483.6" "369.3" "445.2" "514.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5634495844004760" "False" "High" "IsMasterProtein" "O60907" "F-box-like/WD repeat-containing protein TBL1X OS=Homo sapiens OX=9606 GN=TBL1X PE=1 SV=3" "0.000" "False" "17.355" "11" "6" "7" "2" "577" "62.5" "6.55" "17.84" "6" "protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf08513" "6907" "ENSG00000101849" "TBL1X" "A8K044; A8K4J7; hsa:6907; O60907; Q86UY2" "Ectoderm differentiation; Ectoderm differentiation; Rett syndrome" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression" "22" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7451398436155471702" "False" "High" "IsMasterProtein" "Q9BRZ2" "E3 ubiquitin-protein ligase TRIM56 OS=Homo sapiens OX=9606 GN=TRIM56 PE=1 SV=3" "0.000" "False" "17.353" "8" "6" "6" "6" "755" "81.4" "7.74" "18.66" "6" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00643, Pf13445" "81844" "ENSG00000169871" "TRIM56" "hsa:81844; Q6PJS5; Q86VT6; Q8N2H8; Q8NAC0; Q9BRZ2; Q9H031" "" "Regulation of innate immune responses to cytosolic DNA" "1" "0" "1.223" "1.016" "1.353" "1.188" "1.078" "1.175" "0.991" "1.090" "1.139" "123.5" "151.0" "125.5" "167.1" "146.7" "133.1" "145.1" "122.3" "134.6" "140.6" "" "" "" "" "" "" "" "" "" "" "115.7" "125.0" "116.5" "129.2" "125.0" "127.2" "132.6" "108.6" "134.6" "135.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8011732413234136033" "False" "High" "IsMasterProtein" "Q9UJX4" "Anaphase-promoting complex subunit 5 OS=Homo sapiens OX=9606 GN=ANAPC5 PE=1 SV=2" "0.000" "False" "17.352" "7" "6" "6" "6" "755" "85.0" "6.87" "19.15" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf12862, Pf21371" "51433" "ENSG00000089053" "ANAPC5" "E9PFB2; hsa:51433; Q8N4H7; Q9BQD4; Q9UJX4" "Cell cycle" "Separation of Sister Chromatids; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "1.022" "0.942" "0.954" "0.973" "0.927" "0.871" "0.838" "0.871" "0.955" "770.2" "787.2" "725.7" "734.9" "749.7" "713.6" "670.8" "645.5" "670.5" "735.8" "" "" "" "" "" "" "" "" "" "" "721.7" "651.4" "673.7" "568.1" "639.0" "681.8" "612.9" "573.1" "670.5" "708.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4513402261466963400" "False" "High" "IsMasterProtein" "O75582" "Ribosomal protein S6 kinase alpha-5 OS=Homo sapiens OX=9606 GN=RPS6KA5 PE=1 SV=1" "0.000" "False" "17.334" "6" "6" "7" "5" "802" "89.8" "7.11" "21.11" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433" "9252" "ENSG00000100784" "RPS6KA5" "B7Z2Y5; hsa:9252; O75582; O95316; Q96AF7" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Interleukin-1 (IL-1) structural pathway; Bladder cancer; MAPK signaling pathway; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; p38 MAPK signaling pathway; EGF/EGFR signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Pleural mesothelioma; Hippocampal synaptogenesis and neurogenesis; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling" "Recycling pathway of L1; NCAM signaling for neurite out-growth; ERK/MAPK targets; CREB phosphorylation; CD209 (DC-SIGN) signaling" "22" "1" "0.952" "0.993" "0.973" "0.980" "0.975" "0.927" "0.922" "0.928" "0.990" "1398.4" "1331.5" "1388.3" "1360.3" "1370.2" "1363.9" "1296.9" "1289.6" "1297.1" "1385.0" "" "" "" "" "" "" "" "" "" "" "1310.3" "1101.8" "1288.9" "1051.5" "1167.9" "1303.1" "1185.1" "1145.0" "1297.1" "1333.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8144155955974209704" "False" "High" "IsMasterProtein" "P16220" "Cyclic AMP-responsive element-binding protein 1 OS=Homo sapiens OX=9606 GN=CREB1 PE=1 SV=3" "0.000" "False" "17.329" "18" "4" "6" "2" "327" "35.1" "5.27" "27.09" "4" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf02173" "1385" "ENSG00000118260" "CREB1" "hsa:1385; P16220; P21934; Q6V963; Q9UMA7" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; Energy metabolism; miRNAs involved in DNA damage response; Folate-alcohol and cancer pathway hypotheses; Sterol regulatory element-binding proteins (SREBP) signaling; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; MFAP5-mediated ovarian cancer cell motility and invasiveness; Ovarian infertility; MECP2 and associated Rett syndrome; Transcription factor regulation in adipogenesis; BDNF-TrkB signaling; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; p38 MAPK signaling pathway; NO/cGMP/PKG mediated neuroprotection; White fat cell differentiation; PI3K-Akt signaling pathway; Phosphodiesterases in neuronal function; Acute viral myocarditis; Thermogenesis; EGF/EGFR signaling pathway; G1 to S cell cycle control; Fragile X syndrome; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; Hepatitis B infection; Melanoma; mBDNF and proBDNF regulation of GABA neurotransmission; CAMKK2 pathway; GPR143 in melanocytes and retinal pigment epithelium cells; Galanin receptor pathway; Neuroinflammation and glutamatergic signaling; Vasopressin-regulated water reabsorption; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Rubinstein-Taybi syndrome 1; Smith-Magenis and Potocki-Lupski syndrome copy number variation; Interferon type I signaling pathways; T-cell receptor signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling" "ADORA2B mediated anti-inflammatory cytokines production; Transcriptional regulation of granulopoiesis; FCGR3A-mediated IL10 synthesis; HCMV Early Events; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; NGF-stimulated transcription; Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; MECP2 regulates transcription of neuronal ligands; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; Regulation of MECP2 expression and activity; CREB phosphorylation; Gastrin-CREB signalling pathway via PKC and MAPK; NOTCH2 intracellular domain regulates transcription; MECP2 regulates neuronal receptors and channels; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of Adenylate Cyclase; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde; PKA-mediated phosphorylation of CREB; CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling; MECP2 regulates transcription factors" "85" "2" "0.975" "0.954" "0.961" "0.924" "0.891" "0.930" "0.952" "0.890" "0.924" "2270.1" "2214.2" "2165.2" "2182.0" "2097.7" "2023.4" "2110.3" "2160.2" "2021.0" "2098.3" "" "" "" "" "" "" "" "" "" "" "2127.1" "1832.3" "2010.1" "1686.8" "1788.0" "1933.1" "1928.3" "1918.0" "2021.0" "2020.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4672476971480337418" "False" "High" "IsMasterProtein" "P67870" "Casein kinase II subunit beta OS=Homo sapiens OX=9606 GN=CSNK2B PE=1 SV=1" "0.000" "False" "17.329" "27" "5" "5" "5" "215" "24.9" "5.55" "17.38" "5" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf01214" "1460" "ENSG00000204435; ENSG00000206406; ENSG00000224398; ENSG00000224774; ENSG00000228875; ENSG00000230700; ENSG00000232960" "CSNK2B" "B0UXA9; hsa:1460; P07312; P13862; P67870; Q4VX47" "Alzheimer's disease and miRNA effects; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Measles virus infection; Pleural mesothelioma; Alzheimer's disease; HDAC6 interactions in the central nervous system" "Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Neutrophil degranulation; Condensation of Prometaphase Chromosomes; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Synthesis of PC" "21" "0" "0.972" "1.057" "0.866" "0.974" "0.976" "0.912" "0.961" "0.948" "1.009" "664.2" "645.3" "702.3" "575.0" "646.7" "648.1" "605.8" "638.5" "629.9" "670.2" "" "" "" "" "" "" "" "" "" "" "622.3" "534.0" "652.0" "444.5" "551.2" "619.2" "553.6" "566.9" "629.9" "645.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1337195466672693139" "False" "High" "IsMasterProtein" "Q9BZX2" "Uridine-cytidine kinase 2 OS=Homo sapiens OX=9606 GN=UCK2 PE=1 SV=1" "0.000" "False" "17.323" "23" "6" "8" "5" "261" "29.3" "6.70" "21.02" "6" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00485" "7371" "ENSG00000143179" "UCK2" "hsa:7371; Q5VV91; Q7KZV3; Q92528; Q96KG5; Q9BU42; Q9BZX2" "Fluoropyrimidine activity; Pyrimidine metabolism" "Pyrimidine salvage" "3" "0" "1.024" "0.925" "1.001" "1.027" "0.995" "0.993" "0.917" "0.961" "1.012" "445.4" "456.0" "412.0" "445.9" "457.3" "443.2" "442.4" "408.6" "427.9" "451.0" "" "" "" "" "" "" "" "" "" "" "417.3" "377.4" "382.5" "344.7" "389.8" "423.5" "404.2" "362.8" "427.9" "434.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1914895012756735579" "False" "High" "IsMasterProtein" "P08240" "Signal recognition particle receptor subunit alpha OS=Homo sapiens OX=9606 GN=SRPRA PE=1 SV=2" "0.000" "False" "17.298" "9" "6" "7" "6" "638" "69.8" "8.95" "21.43" "6" "cell organization and biogenesis;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00448, Pf02881, Pf04086" "6734" "ENSG00000182934" "SRPRA" "A6NIB3; B2R5Z8; B4E0H3; E9PJS4; hsa:6734; P08240; Q9BVJ4" "" "SRP-dependent cotranslational protein targeting to membrane; XBP1(S) activates chaperone genes" "2" "0" "0.949" "0.979" "1.030" "1.031" "1.007" "1.184" "1.140" "1.117" "1.077" "1000.3" "949.2" "979.1" "1030.5" "1031.4" "1007.2" "1184.5" "1140.3" "1117.2" "1077.2" "" "" "" "" "" "" "" "" "" "" "937.3" "785.5" "909.0" "796.6" "879.1" "962.3" "1082.3" "1012.5" "1117.2" "1037.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6685402705848511390" "False" "High" "IsMasterProtein" "Q92820" "Gamma-glutamyl hydrolase OS=Homo sapiens OX=9606 GN=GGH PE=1 SV=2" "0.000" "False" "17.281" "23" "7" "8" "7" "318" "35.9" "7.11" "20.92" "7" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00117, Pf07722" "8836" "ENSG00000137563" "GGH" "hsa:8836; Q92820" "Fluoropyrimidine activity" "Neutrophil degranulation" "2" "0" "1.016" "1.007" "1.049" "1.034" "0.946" "1.000" "0.974" "1.099" "1.079" "339.4" "345.0" "341.9" "355.9" "351.0" "321.0" "339.4" "330.5" "373.2" "366.2" "" "" "" "" "" "" "" "" "" "" "318.0" "285.5" "317.4" "275.2" "299.2" "306.7" "310.1" "293.4" "373.2" "352.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4235464357787345308" "False" "High" "IsMasterProtein" "Q15370" "Elongin-B OS=Homo sapiens OX=9606 GN=ELOB PE=1 SV=1" "0.000" "False" "17.265" "34" "5" "13" "5" "118" "13.1" "4.88" "34.93" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00240" "6923" "ENSG00000103363" "ELOB" "B7WPD3; hsa:6923; Q15370" "Dual hijack model of Vif in HIV infection; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2; Modulators of TCR signaling and T cell activation" "Regulation of expression of SLITs and ROBOs; Inactivation of CSF3 (G-CSF) signaling; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Evasion by RSV of host interferon responses" "22" "0" "0.971" "0.933" "0.838" "0.900" "0.941" "0.951" "0.965" "0.890" "0.896" "1428.2" "1386.7" "1332.5" "1197.1" "1285.2" "1343.2" "1358.6" "1378.5" "1271.7" "1279.1" "" "" "" "" "" "" "" "" "" "" "1338.2" "1147.5" "1237.1" "925.4" "1095.4" "1283.3" "1241.4" "1224.0" "1271.7" "1231.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "614531152509290275" "False" "High" "IsMasterProtein" "Q9BRD0" "BUD13 homolog OS=Homo sapiens OX=9606 GN=BUD13 PE=1 SV=1" "0.000" "False" "17.246" "11" "5" "6" "5" "619" "70.5" "9.86" "17.59" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf09736" "84811" "ENSG00000137656" "BUD13" "A8K0S0; hsa:84811; Q96LS7; Q9BRD0" "" "mRNA Splicing - Major Pathway" "1" "0" "1.028" "1.013" "1.499" "1.369" "1.181" "1.840" "1.782" "1.652" "1.326" "160.8" "165.3" "162.9" "241.0" "220.2" "189.9" "295.8" "286.6" "265.7" "213.3" "" "" "" "" "" "" "" "" "" "" "150.7" "136.8" "151.2" "186.3" "187.7" "181.4" "270.3" "254.5" "265.7" "205.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8059296943260836861" "False" "High" "IsMasterProtein" "Q15286" "Ras-related protein Rab-35 OS=Homo sapiens OX=9606 GN=RAB35 PE=1 SV=1" "0.000" "False" "17.230" "23" "5" "8" "3" "201" "23.0" "8.29" "27.87" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "11021" "ENSG00000111737" "RAB35" "B2R6E0; B4E390; hsa:11021; Q15286" "" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; TBC/RABGAPs" "3" "0" "0.933" "1.010" "0.967" "0.945" "1.037" "0.893" "0.993" "0.958" "0.987" "964.5" "899.7" "974.3" "932.7" "911.5" "1000.1" "861.5" "957.3" "924.3" "951.8" "" "" "" "" "" "" "" "" "" "" "903.7" "744.4" "904.6" "721.0" "776.9" "955.5" "787.2" "850.0" "924.3" "916.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9037349892504840241" "False" "High" "IsMasterProtein" "O00764" "Pyridoxal kinase OS=Homo sapiens OX=9606 GN=PDXK PE=1 SV=1" "0.000" "False" "17.228" "20" "5" "7" "5" "312" "35.1" "6.13" "22.49" "5" "other metabolic processes" "non-structural extracellular;nucleus;other cell component" "kinase activity;other molecular function" "Pf08543" "8566" "ENSG00000160209" "PDXK" "O00764; Q7Z2Y0; Q9BS02" "" "Neutrophil degranulation; Vitamin B6 activation to pyridoxal phosphate" "2" "0" "1.007" "0.961" "1.093" "0.956" "1.136" "0.990" "0.989" "1.014" "1.027" "641.4" "645.7" "616.4" "701.3" "613.3" "728.5" "635.0" "634.4" "650.4" "658.5" "" "" "" "" "" "" "" "" "" "" "601.0" "534.3" "572.3" "542.1" "522.8" "696.0" "580.2" "563.3" "650.4" "634.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6808375425283248797" "False" "High" "IsMasterProtein" "Q13572" "Inositol-tetrakisphosphate 1-kinase OS=Homo sapiens OX=9606 GN=ITPK1 PE=1 SV=2" "0.000" "False" "17.225" "13" "5" "8" "5" "414" "45.6" "6.16" "24.35" "5" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf05770, Pf17927" "3705" "ENSG00000100605; ENSG00000274958" "ITPK1" "hsa:3705; Q13572; Q9BTL6; Q9H2E7" "2q37 copy number variation syndrome" "Factors involved in megakaryocyte development and platelet production; Synthesis of IP3 and IP4 in the cytosol; Synthesis of pyrophosphates in the cytosol" "4" "0" "0.960" "1.007" "1.014" "1.028" "1.009" "0.988" "0.979" "0.931" "1.003" "1221.5" "1172.8" "1229.9" "1238.7" "1255.9" "1232.4" "1206.4" "1195.4" "1137.5" "1225.5" "" "" "" "" "" "" "" "" "" "" "1144.6" "970.4" "1141.8" "957.6" "1070.5" "1177.5" "1102.4" "1061.4" "1137.5" "1180.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "837370257864581378" "False" "High" "IsMasterProtein" "Q01415" "N-acetylgalactosamine kinase OS=Homo sapiens OX=9606 GN=GALK2 PE=1 SV=1" "0.000" "False" "17.214" "15" "7" "11" "7" "458" "50.3" "6.61" "33.00" "7" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf00288, Pf08544, Pf10509" "2585" "ENSG00000156958" "GALK2" "hsa:2585; Q01415; Q7Z4Q4" "" "" "0" "0" "0.991" "1.040" "1.053" "1.002" "0.964" "0.985" "0.952" "0.951" "0.970" "663.8" "658.1" "690.5" "699.2" "664.9" "640.2" "653.9" "631.7" "631.0" "643.8" "" "" "" "" "" "" "" "" "" "" "622.0" "544.6" "641.1" "540.5" "566.7" "611.6" "597.5" "560.9" "631.0" "619.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5669236386910036788" "False" "High" "IsMasterProtein" "P46783" "Small ribosomal subunit protein eS10 OS=Homo sapiens OX=9606 GN=RPS10 PE=1 SV=1" "0.000" "False" "17.210" "38" "6" "13" "6" "165" "18.9" "10.15" "25.03" "6" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf03501" "6204" "ENSG00000124614" "RPS10" "B2R4E3; hsa:6204; P46783; Q5TZC0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.040" "1.049" "1.042" "1.056" "1.089" "1.251" "1.186" "1.207" "1.088" "468.1" "487.0" "491.3" "487.8" "494.4" "509.8" "585.7" "555.0" "565.2" "509.1" "" "" "" "" "" "" "" "" "" "" "438.6" "403.0" "456.1" "377.1" "421.4" "487.0" "535.2" "492.8" "565.2" "490.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5177067630619702561" "False" "High" "IsMasterProtein" "Q969S9" "Ribosome-releasing factor 2, mitochondrial OS=Homo sapiens OX=9606 GN=GFM2 PE=1 SV=1" "0.000" "False" "17.195" "8" "6" "6" "6" "779" "86.5" "6.51" "20.22" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "84340" "ENSG00000164347" "GFM2" "A0AR28; hsa:84340; Q8N6D8; Q8WYI0; Q969S9; Q9H6Z1" "" "Mitochondrial translation termination" "1" "0" "1.005" "1.012" "1.042" "1.022" "1.001" "1.032" "0.984" "1.013" "1.037" "710.8" "714.3" "719.4" "741.0" "726.3" "711.4" "733.9" "699.2" "720.3" "736.9" "" "" "" "" "" "" "" "" "" "" "666.0" "591.1" "667.9" "572.8" "619.1" "679.7" "670.6" "620.8" "720.3" "709.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3530209516211162637" "False" "High" "IsMasterProtein" "Q5JRA6" "Transport and Golgi organization protein 1 homolog OS=Homo sapiens OX=9606 GN=MIA3 PE=1 SV=1" "0.000" "False" "17.189" "4" "7" "7" "7" "1907" "213.6" "4.84" "19.27" "7" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf07653" "375056" "ENSG00000154305" "MIA3" "A8K2S0; A8MT05; A8MT13; B7Z430; hsa:375056; Q14083; Q3S4X3; Q5JRA5; Q5JRA6; Q5JRB0; Q5JRB1; Q5JRB2; Q6UVY8; Q86Y60; Q8N8M5; Q92580" "Type I collagen synthesis in the context of osteogenesis imperfecta" "Cargo concentration in the ER; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "4" "0" "1.000" "0.890" "1.065" "1.045" "1.049" "1.367" "1.289" "1.283" "1.072" "792.5" "792.7" "705.3" "843.7" "828.3" "831.0" "1083.1" "1021.4" "1017.0" "849.9" "" "" "" "" "" "" "" "" "" "" "742.6" "655.9" "654.8" "652.2" "706.0" "793.9" "989.6" "906.9" "1017.0" "818.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7697340015663074004" "False" "High" "IsMasterProtein" "P56211" "cAMP-regulated phosphoprotein 19 OS=Homo sapiens OX=9606 GN=ARPP19 PE=1 SV=2" "0.000" "False" "17.185" "33" "3" "9" "2" "112" "12.3" "9.09" "32.22" "3" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf04667" "10776" "ENSG00000128989" "ARPP19" "B2R497; hsa:10776; P56211; Q6IAM2; Q86TA6; Q9UD70" "" "MASTL Facilitates Mitotic Progression" "1" "0" "1.050" "1.058" "1.009" "1.081" "0.989" "0.936" "0.923" "0.816" "1.015" "167.6" "176.0" "177.4" "169.2" "181.2" "165.8" "156.9" "154.7" "136.7" "170.1" "" "" "" "" "" "" "" "" "" "" "157.1" "145.6" "164.7" "130.8" "154.5" "158.4" "143.4" "137.3" "136.7" "163.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400843138587659979" "False" "High" "IsMasterProtein" "P98175" "RNA-binding protein 10 OS=Homo sapiens OX=9606 GN=RBM10 PE=1 SV=3" "0.000" "False" "17.183" "6" "6" "7" "4" "930" "103.5" "5.97" "23.31" "6" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641, Pf01585, Pf17780" "8241" "ENSG00000182872" "RBM10" "A0A0A0MR66; C4AM81; hsa:8241; P98175; Q14136; Q5JRR2; Q9BTE4; Q9BTX0; Q9NTB1" "" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "2" "1" "0.998" "1.061" "1.012" "1.013" "1.024" "1.378" "1.279" "1.254" "1.111" "628.1" "627.1" "666.8" "635.4" "636.6" "643.0" "865.3" "803.5" "788.0" "698.1" "" "" "" "" "" "" "" "" "" "" "588.6" "518.9" "619.0" "491.2" "542.6" "614.3" "790.7" "713.4" "788.0" "672.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1839612719642205858" "False" "High" "IsMasterProtein" "P09417" "Dihydropteridine reductase OS=Homo sapiens OX=9606 GN=QDPR PE=1 SV=2" "0.000" "False" "17.177" "32" "5" "9" "5" "244" "25.8" "7.37" "35.90" "5" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00106" "5860" "ENSG00000151552" "QDPR" "A8K158; B3KW71; hsa:5860; P09417; Q53F52; Q9H3M5" "" "Phenylalanine metabolism" "1" "0" "0.967" "0.949" "1.028" "1.032" "1.015" "0.955" "0.934" "1.052" "0.994" "637.3" "616.2" "605.0" "655.2" "657.8" "646.8" "608.5" "595.3" "670.8" "633.2" "" "" "" "" "" "" "" "" "" "" "597.2" "509.9" "561.7" "506.5" "560.7" "618.0" "556.0" "528.6" "670.8" "609.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5188184621199488866" "False" "High" "IsMasterProtein" "Q9GZT3" "SRA stem-loop-interacting RNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SLIRP PE=1 SV=1" "0.000" "False" "17.170" "50" "5" "6" "5" "109" "12.3" "10.24" "22.61" "5" "other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "" "Pf00076" "81892" "ENSG00000119705" "SLIRP" "hsa:81892; J3KMY7; Q9GZT3" "" "Mitochondrial RNA degradation" "1" "0" "1.039" "1.018" "0.990" "1.005" "0.967" "0.999" "1.017" "0.918" "0.985" "839.8" "872.3" "855.2" "831.5" "844.0" "811.8" "838.6" "854.1" "771.1" "827.0" "" "" "" "" "" "" "" "" "" "" "786.9" "721.8" "793.9" "642.8" "719.4" "775.6" "766.2" "758.4" "771.1" "796.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2017615054723730630" "False" "High" "IsMasterProtein" "Q6N069" "N-alpha-acetyltransferase 16, NatA auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA16 PE=1 SV=2" "0.000" "False" "17.163" "6" "6" "10" "2" "864" "101.4" "7.87" "28.26" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf07719, Pf12569" "79612" "ENSG00000172766" "NAA16" "B0QZ59; hsa:79612; Q5VSP9; Q6N069; Q6P2D5; Q8N5J3; Q8N870" "" "" "0" "0" "1.293" "1.046" "1.164" "1.158" "1.158" "1.031" "1.079" "1.081" "1.086" "315.5" "408.0" "329.9" "367.3" "365.5" "365.5" "325.3" "340.5" "340.9" "342.7" "" "" "" "" "" "" "" "" "" "" "295.6" "337.6" "306.3" "283.9" "311.5" "349.2" "297.2" "302.3" "340.9" "329.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5148486115263509013" "False" "High" "IsMasterProtein" "Q9C0B0" "RING finger protein unkempt homolog OS=Homo sapiens OX=9606 GN=UNK PE=1 SV=2" "0.000" "False" "17.162" "6" "6" "6" "6" "810" "88.0" "6.86" "20.52" "6" "developmental processes;other biological processes" "other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00642, Pf18384" "85451" "ENSG00000132478" "UNK" "hsa:85451; Q9C0B0" "" "" "0" "0" "1.036" "1.022" "1.003" "1.061" "1.060" "1.032" "1.062" "1.078" "1.059" "1149.9" "1191.4" "1174.8" "1153.4" "1219.9" "1219.2" "1187.1" "1221.6" "1239.4" "1218.2" "" "" "" "" "" "" "" "" "" "" "1077.5" "985.8" "1090.7" "891.7" "1039.8" "1164.8" "1084.7" "1084.6" "1239.4" "1172.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "407233124236787373" "False" "High" "IsMasterProtein" "Q96DB5" "Regulator of microtubule dynamics protein 1 OS=Homo sapiens OX=9606 GN=RMDN1 PE=1 SV=1" "0.000" "False" "17.159" "20" "7" "7" "7" "314" "35.8" "8.50" "18.57" "7" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity" "Pf21033" "51115" "ENSG00000176623" "RMDN1" "A9UMZ8; B4DNF5; B4DZW6; B5MC61; C9JSC6; E7EVI2; hsa:51115; Q96DB5; Q9Y398" "" "" "0" "0" "0.950" "1.106" "1.122" "1.173" "1.158" "1.116" "1.065" "1.086" "1.112" "121.5" "115.3" "134.4" "136.3" "142.5" "140.7" "135.5" "129.4" "131.9" "135.1" "" "" "" "" "" "" "" "" "" "" "113.8" "95.4" "124.7" "105.4" "121.5" "134.4" "123.8" "114.9" "131.9" "130.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3864595288643475005" "False" "High" "IsMasterProtein" "P61011" "Signal recognition particle subunit SRP54 OS=Homo sapiens OX=9606 GN=SRP54 PE=1 SV=1" "0.000" "False" "17.141" "13" "7" "10" "7" "504" "55.7" "8.75" "28.73" "7" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00448, Pf02881, Pf02978" "6729" "ENSG00000100883" "SRP54" "B2R759; B4DUW6; hsa:6729; P13624; P61011" "VEGFA-VEGFR2 signaling; mRNA processing" "SRP-dependent cotranslational protein targeting to membrane" "3" "0" "1.009" "1.054" "1.045" "1.083" "1.055" "1.033" "1.034" "1.041" "1.055" "907.4" "915.5" "956.9" "948.6" "982.6" "957.3" "937.0" "938.6" "944.9" "957.3" "" "" "" "" "" "" "" "" "" "" "850.3" "757.5" "888.4" "733.3" "837.6" "914.6" "856.1" "833.3" "944.9" "921.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1177482447512558462" "False" "High" "IsMasterProtein" "Q9NUV9" "GTPase IMAP family member 4 OS=Homo sapiens OX=9606 GN=GIMAP4 PE=1 SV=1" "0.000" "False" "17.139" "19" "6" "6" "6" "329" "37.5" "7.81" "19.30" "6" "" "cytosol;other cell component" "other molecular function" "Pf04548" "55303" "ENSG00000133574" "GIMAP4" "hsa:55303; Q9NUV9" "" "" "0" "0" "0.965" "0.942" "1.044" "1.044" "0.989" "1.246" "1.195" "1.216" "1.063" "523.6" "505.2" "493.3" "546.9" "546.9" "518.1" "652.4" "625.6" "636.9" "556.7" "" "" "" "" "" "" "" "" "" "" "490.7" "418.1" "458.0" "422.8" "466.1" "495.0" "596.1" "555.5" "636.9" "536.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4830311805247258078" "False" "High" "IsMasterProtein" "Q9NPD3" "Exosome complex component RRP41 OS=Homo sapiens OX=9606 GN=EXOSC4 PE=1 SV=3" "0.000" "False" "17.138" "21" "5" "7" "5" "245" "26.4" "6.52" "21.63" "5" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "54512" "ENSG00000178896" "EXOSC4" "hsa:54512; Q9NPD3" "Ciliary landscape" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "7" "0" "1.046" "1.041" "1.041" "1.059" "1.100" "1.079" "1.108" "1.131" "1.063" "331.0" "346.2" "344.7" "344.6" "350.5" "364.0" "357.3" "366.8" "374.3" "351.8" "" "" "" "" "" "" "" "" "" "" "310.2" "286.5" "320.0" "266.4" "298.8" "347.8" "326.5" "325.7" "374.3" "338.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5329658274444496515" "False" "High" "IsMasterProtein" "O95394" "Phosphoacetylglucosamine mutase OS=Homo sapiens OX=9606 GN=PGM3 PE=1 SV=1" "0.000" "False" "17.136" "10" "6" "8" "6" "542" "59.8" "6.25" "21.80" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00408, Pf02878, Pf21404, Pf21405" "5238" "ENSG00000013375" "PGM3" "B2RB65; B4DX94; D6RF12; E1P547; E9PF86; hsa:5238; O95394; Q5JWR4; Q96J46; Q9H8G5; Q9NS94; Q9NTT6; Q9UFV5; Q9UIY2" "UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "Synthesis of UDP-N-acetyl-glucosamine" "3" "0" "0.928" "0.923" "0.990" "0.894" "0.891" "0.928" "0.904" "0.893" "0.918" "1288.4" "1195.9" "1189.2" "1276.0" "1152.1" "1147.3" "1195.0" "1164.5" "1150.1" "1182.5" "" "" "" "" "" "" "" "" "" "" "1207.2" "989.6" "1104.0" "986.4" "982.0" "1096.2" "1092.0" "1034.0" "1150.1" "1138.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4704340040215325088" "False" "High" "IsMasterProtein" "Q9GZN8" "Adipose-secreted signaling protein OS=Homo sapiens OX=9606 GN=ADISSP PE=1 SV=3" "0.000" "False" "17.109" "34" "4" "5" "4" "174" "19.3" "6.84" "14.34" "4" "other metabolic processes;other biological processes" "non-structural extracellular" "other molecular function" "Pf15006" "54976" "ENSG00000101220" "ADISSP" "A8K4J0; D3DVX8; hsa:54976; Q5JX81; Q9GZN8; Q9NWX3" "" "" "0" "0" "1.009" "1.082" "1.037" "1.026" "1.077" "1.052" "1.072" "1.066" "1.092" "359.0" "362.4" "388.5" "372.3" "368.2" "386.6" "377.7" "385.1" "382.7" "392.2" "" "" "" "" "" "" "" "" "" "" "336.4" "299.9" "360.6" "287.8" "313.9" "369.4" "345.2" "341.9" "382.7" "377.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3257917255703740656" "False" "High" "IsMasterProtein" "Q14181" "DNA polymerase alpha subunit B OS=Homo sapiens OX=9606 GN=POLA2 PE=1 SV=2" "0.000" "False" "17.104" "9" "6" "10" "6" "598" "65.9" "5.24" "30.90" "6" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport" "cytosol;nucleus" "nucleic acid binding activity" "Pf04042, Pf08418" "23649" "ENSG00000014138" "POLA2" "B4DNB4; hsa:23649; Q14181; Q9BPV3" "Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "Activation of the pre-replicative complex; Defective pyroptosis; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate" "12" "0" "0.995" "1.020" "1.030" "1.013" "1.009" "0.965" "0.973" "0.940" "0.997" "843.6" "839.0" "860.2" "869.0" "854.8" "851.3" "813.8" "820.6" "793.0" "840.7" "" "" "" "" "" "" "" "" "" "" "790.4" "694.3" "798.6" "671.7" "728.6" "813.4" "743.6" "728.6" "793.0" "809.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6767865713948388298" "False" "High" "IsMasterProtein" "P49720" "Proteasome subunit beta type-3 OS=Homo sapiens OX=9606 GN=PSMB3 PE=1 SV=2" "0.000" "False" "17.091" "30" "5" "8" "5" "205" "22.9" "6.55" "26.89" "5" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00227" "5691" "ENSG00000275903; ENSG00000277791" "PSMB3" "hsa:5691; P31147; P49720; Q0P6J7; Q96E27" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of expression of SLITs and ROBOs; Orc1 removal from chromatin; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "0.905" "0.979" "0.994" "1.003" "1.002" "0.900" "0.990" "0.968" "1.008" "786.1" "711.7" "769.2" "781.2" "788.4" "787.7" "707.7" "777.9" "760.5" "792.1" "" "" "" "" "" "" "" "" "" "" "736.6" "588.9" "714.1" "603.9" "672.0" "752.6" "646.7" "690.7" "760.5" "762.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2951655110054191757" "False" "High" "IsMasterProtein" "Q5VW32" "BRO1 domain-containing protein BROX OS=Homo sapiens OX=9606 GN=BROX PE=1 SV=1" "0.000" "False" "17.089" "16" "7" "7" "7" "411" "46.4" "7.65" "21.72" "7" "cell cycle OR cell proliferation;cell organization and biogenesis" "other membranes;nucleus" "" "Pf03097" "148362" "ENSG00000162819" "BROX" "B7Z9G5; hsa:148362; Q5VW32; Q96MG1" "" "" "0" "0" "0.959" "0.967" "0.943" "0.967" "1.005" "0.948" "0.962" "0.994" "0.993" "2262.0" "2169.3" "2186.2" "2133.5" "2186.3" "2274.1" "2144.3" "2176.9" "2248.8" "2245.9" "" "" "" "" "" "" "" "" "" "" "2119.5" "1795.1" "2029.6" "1649.3" "1863.5" "2172.7" "1959.3" "1932.9" "2248.8" "2162.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3937524236337839102" "False" "High" "IsMasterProtein" "P32121" "Beta-arrestin-2 OS=Homo sapiens OX=9606 GN=ARRB2 PE=1 SV=2" "0.000" "False" "17.083" "12" "5" "6" "5" "409" "46.1" "7.69" "16.92" "5" "cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00339, Pf02752" "409" "ENSG00000141480" "ARRB2" "B4DLW0; B5B0C0; B7WPL3; D3DTK2; H0Y688; hsa:409; P32121; Q0Z8D3; Q2PP19; Q6ICT3; Q8N7Y2; Q9UEQ6" "Corticotropin-releasing hormone signaling pathway; Complement system; Myometrial relaxation and contraction pathways; Wnt signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Hedgehog signaling pathway; Gastrin signaling pathway; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Calcium regulation in cardiac cells" "Ub-specific processing proteases; Activation of SMO; Activated NOTCH1 Transmits Signal to the Nucleus; G alpha (s) signalling events; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "27" "0" "1.052" "1.118" "1.015" "0.970" "0.952" "0.805" "0.955" "0.989" "1.012" "314.3" "330.7" "351.2" "318.9" "305.0" "299.1" "252.9" "300.2" "310.7" "318.1" "" "" "" "" "" "" "" "" "" "" "294.5" "273.6" "326.1" "246.6" "259.9" "285.7" "231.1" "266.5" "310.7" "306.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6104369569183716546" "False" "High" "IsMasterProtein" "P36915" "Guanine nucleotide-binding protein-like 1 OS=Homo sapiens OX=9606 GN=GNL1 PE=1 SV=2" "0.000" "False" "17.068" "10" "6" "6" "6" "607" "68.6" "5.80" "18.14" "6" "stress response;signal transduction;other biological processes" "non-structural extracellular" "other molecular function" "Pf01926" "2794" "ENSG00000204590; ENSG00000206492; ENSG00000226882; ENSG00000228581; ENSG00000229470; ENSG00000232143; ENSG00000235986" "GNL1" "B0S838; hsa:2794; P36915; Q96CT5" "" "" "0" "0" "0.984" "0.995" "1.030" "1.057" "1.048" "1.001" "0.959" "0.996" "1.030" "771.3" "758.8" "767.3" "794.1" "815.0" "808.1" "771.8" "740.0" "768.3" "794.5" "" "" "" "" "" "" "" "" "" "" "722.7" "627.9" "712.4" "613.9" "694.7" "772.1" "705.2" "657.1" "768.3" "765.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4594360635056461095" "False" "High" "IsMasterProtein" "O75648" "Mitochondrial tRNA-specific 2-thiouridylase 1 OS=Homo sapiens OX=9606 GN=TRMU PE=1 SV=2" "0.000" "False" "17.064" "19" "6" "7" "6" "421" "47.7" "8.03" "11.65" "6" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf03054, Pf20258, Pf20259" "55687" "ENSG00000100416" "TRMU" "A8K3U7; hsa:55687; O75648; Q05C99; Q5W9C8; Q66K31; Q6ICC3; Q9NWC1" "" "tRNA modification in the mitochondrion" "1" "0" "1.736" "1.030" "1.342" "1.256" "1.369" "1.209" "1.050" "1.344" "1.178" "315.1" "547.2" "324.6" "423.0" "395.9" "431.6" "381.1" "330.9" "423.5" "371.3" "" "" "" "" "" "" "" "" "" "" "295.3" "452.8" "301.3" "327.0" "337.4" "412.3" "348.2" "293.8" "423.5" "357.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1858767456070720034" "False" "High" "IsMasterProtein" "P55735" "Protein SEC13 homolog OS=Homo sapiens OX=9606 GN=SEC13 PE=1 SV=3" "0.000" "False" "17.062" "21" "5" "6" "5" "322" "35.5" "5.48" "22.13" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "6396" "ENSG00000157020" "SEC13" "A8MV37; B4DXJ1; hsa:6396; P55735; Q5BJF0; Q9BRM6; Q9BUG7" "Sterol regulatory element-binding proteins (SREBP) signaling" "Separation of Sister Chromatids; MHC class II antigen presentation; HCMV Late Events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Amino acids regulate mTORC1; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; COPII-mediated vesicle transport; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Postmitotic nuclear pore complex (NPC) reformation" "40" "0" "0.965" "0.941" "1.039" "1.003" "0.983" "0.925" "0.874" "1.021" "1.019" "481.0" "464.0" "452.8" "499.7" "482.6" "472.6" "444.8" "420.6" "491.2" "490.3" "" "" "" "" "" "" "" "" "" "" "450.7" "383.9" "420.4" "386.3" "411.4" "451.5" "406.5" "373.4" "491.2" "472.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2723380110301134702" "False" "High" "IsMasterProtein" "Q9UKS6" "Protein kinase C and casein kinase substrate in neurons protein 3 OS=Homo sapiens OX=9606 GN=PACSIN3 PE=1 SV=2" "0.000" "False" "17.060" "15" "5" "6" "5" "424" "48.5" "6.18" "22.08" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00611, Pf14604" "29763" "ENSG00000165912" "PACSIN3" "A6NH84; hsa:29763; Q9H331; Q9NWV9; Q9UKS6" "" "Clathrin-mediated endocytosis" "1" "0" "0.954" "1.089" "1.076" "1.047" "1.048" "1.121" "1.060" "0.996" "1.056" "493.0" "470.3" "536.7" "530.6" "516.2" "516.7" "552.4" "522.6" "490.9" "520.6" "" "" "" "" "" "" "" "" "" "" "461.9" "389.1" "498.2" "410.2" "440.0" "493.7" "504.7" "464.0" "490.9" "501.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1190260410723795831" "False" "High" "IsMasterProtein" "Q14257" "Reticulocalbin-2 OS=Homo sapiens OX=9606 GN=RCN2 PE=1 SV=1" "0.000" "False" "17.037" "19" "6" "11" "6" "317" "36.9" "4.40" "32.68" "6" "" "ER/Golgi;nucleus" "other molecular function" "Pf13202, Pf13499" "5955" "ENSG00000117906" "RCN2" "A8MTG6; F8WCY5; hsa:5955; Q14257; Q53XN8" "" "" "0" "0" "0.956" "0.955" "0.826" "0.897" "0.967" "0.782" "0.796" "0.890" "0.929" "1656.8" "1584.4" "1582.3" "1367.9" "1485.5" "1602.2" "1295.0" "1318.9" "1473.9" "1538.7" "" "" "" "" "" "" "" "" "" "" "1552.4" "1311.0" "1469.0" "1057.4" "1266.2" "1530.8" "1183.2" "1171.0" "1473.9" "1481.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3951454542439150493" "False" "High" "IsMasterProtein" "Q9HB40" "Retinoid-inducible serine carboxypeptidase OS=Homo sapiens OX=9606 GN=SCPEP1 PE=1 SV=1" "0.000" "False" "17.035" "11" "6" "7" "6" "452" "50.8" "5.81" "22.20" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00450" "59342" "ENSG00000121064" "SCPEP1" "hsa:59342; Q96A94; Q9H3F0; Q9HB40" "" "" "0" "0" "0.940" "0.997" "0.980" "1.007" "1.020" "0.949" "0.992" "0.983" "0.971" "985.3" "925.9" "981.8" "965.7" "992.5" "1005.5" "934.8" "977.2" "968.2" "956.8" "" "" "" "" "" "" "" "" "" "" "923.2" "766.2" "911.5" "746.5" "845.9" "960.6" "854.2" "867.6" "968.2" "921.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7873771796286241695" "False" "High" "IsMasterProtein" "A6NHL2" "Tubulin alpha chain-like 3 OS=Homo sapiens OX=9606 GN=TUBAL3 PE=1 SV=2" "0.000" "False" "17.025" "10" "5" "16" "1" "446" "49.9" "6.05" "46.38" "5" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "79861" "ENSG00000178462" "TUBAL3" "A6NHL2; B4DKL2; hsa:79861; Q4QQJ5; Q9H6Z0" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; Cilium Assembly; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling" "32" "0" "0.998" "0.960" "1.188" "1.076" "0.956" "1.081" "0.982" "1.278" "1.005" "90.0" "89.8" "86.4" "107.0" "96.9" "86.1" "97.3" "88.4" "115.1" "90.5" "" "" "" "" "" "" "" "" "" "" "84.4" "74.3" "80.2" "82.7" "82.6" "82.3" "88.9" "78.5" "115.1" "87.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3133917976218081073" "False" "High" "IsMasterProtein" "Q9Y3D8" "Adenylate kinase isoenzyme 6 OS=Homo sapiens OX=9606 GN=AK6 PE=1 SV=1" "0.000" "False" "17.021" "38" "5" "6" "5" "172" "20.0" "4.58" "21.56" "5" "other metabolic processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf13238" "102157402" "ENSG00000085231; ENSG00000279247" "AK6" "A8MSZ6; hsa:102157402; Q5F2S9; Q9Y3D8" "" "Interconversion of nucleotide di- and triphosphates" "1" "0" "0.945" "0.944" "0.962" "1.066" "1.030" "0.947" "0.918" "0.965" "0.979" "788.3" "745.1" "744.4" "758.1" "840.4" "812.1" "746.7" "724.0" "760.9" "772.1" "" "" "" "" "" "" "" "" "" "" "738.6" "616.5" "691.1" "586.1" "716.3" "775.9" "682.3" "642.8" "760.9" "743.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9221367924290970171" "False" "High" "IsMasterProtein" "Q07812" "Apoptosis regulator BAX OS=Homo sapiens OX=9606 GN=BAX PE=1 SV=1" "0.000" "False" "17.020" "30" "4" "7" "4" "192" "21.2" "5.22" "22.29" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00452" "581" "ENSG00000087088" "BAX" "A8K4W1; hsa:581; P55269; Q07812; Q07814; Q07815; Q8WZ49; Q9NR76; Q9NYG7; Q9UCZ6; Q9UCZ7; Q9UQD6" "miRNA regulation of DNA damage response; TP53 network; Leptin signaling pathway; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Mammary gland development pathway - Involution (Stage 4 of 4); Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Overview of nanoparticle effects; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Regulation of apoptosis by parathyroid hormone-related protein; miRNA regulation of p53 pathway in prostate cancer; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Melanoma; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; p53 transcriptional gene network; Pleural mesothelioma; Complement system in neuronal development and plasticity; Urotensin-II-mediated signaling pathway; TROP2 regulatory signaling; IL-26 signaling pathways; HDAC6 interactions in the central nervous system; DNA damage response; DNA damage response (only ATM dependent)" "Release of apoptotic factors from the mitochondria; Pyroptosis; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Transcriptional regulation by RUNX2; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Activation, translocation and oligomerization of BAX; NTRK3 as a dependence receptor" "48" "0" "1.060" "0.999" "1.073" "1.039" "1.060" "0.882" "0.921" "0.953" "1.027" "465.0" "492.8" "464.7" "499.1" "483.1" "492.7" "410.1" "428.3" "442.9" "477.4" "" "" "" "" "" "" "" "" "" "" "435.7" "407.8" "431.4" "385.8" "411.8" "470.7" "374.7" "380.3" "442.9" "459.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2205363031532401399" "False" "High" "IsMasterProtein" "Q16763" "Ubiquitin-conjugating enzyme E2 S OS=Homo sapiens OX=9606 GN=UBE2S PE=1 SV=2" "0.000" "False" "17.003" "16" "3" "5" "3" "222" "23.8" "8.38" "20.63" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "27338" "ENSG00000108106" "UBE2S" "hsa:27338; Q16763; Q9BTC1" "" "Antigen processing: Ubiquitination & Proteasome degradation; Senescence-Associated Secretory Phenotype (SASP); APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "19" "0" "0.957" "0.975" "1.022" "1.071" "1.071" "0.963" "0.973" "0.980" "1.058" "655.4" "627.1" "639.2" "669.9" "702.2" "701.7" "631.5" "637.6" "642.6" "693.5" "" "" "" "" "" "" "" "" "" "" "614.1" "518.9" "593.4" "517.8" "598.5" "670.4" "577.0" "566.2" "642.6" "667.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1760362922626917016" "False" "High" "IsMasterProtein" "Q14011" "Cold-inducible RNA-binding protein OS=Homo sapiens OX=9606 GN=CIRBP PE=1 SV=1" "0.000" "False" "16.979" "26" "4" "9" "4" "172" "18.6" "9.51" "25.64" "4" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "1153" "ENSG00000099622" "CIRBP" "B3KT17; B4E2X2; hsa:1153; Q14011" "" "" "0" "0" "1.119" "1.031" "1.029" "1.050" "1.014" "1.028" "0.991" "1.026" "1.016" "894.9" "1001.1" "922.6" "920.7" "939.9" "907.9" "920.0" "886.9" "918.1" "909.7" "" "" "" "" "" "" "" "" "" "" "838.6" "828.4" "856.5" "711.8" "801.1" "867.4" "840.7" "787.5" "918.1" "875.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5687850324260335343" "False" "High" "IsMasterProtein" "Q16875" "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 OS=Homo sapiens OX=9606 GN=PFKFB3 PE=1 SV=1" "0.000" "False" "16.970" "11" "6" "9" "4" "520" "59.6" "8.21" "29.29" "6" "other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00300, Pf01591" "5209" "ENSG00000170525" "PFKFB3" "B7Z955; hsa:5209; O43622; O75902; Q16875; Q5VX15; Q5VX18; Q5VX19" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" "3" "1" "1.104" "0.999" "1.076" "1.090" "1.038" "1.058" "1.036" "1.026" "1.013" "280.8" "310.1" "280.6" "302.2" "306.0" "291.3" "297.0" "290.8" "288.1" "284.5" "" "" "" "" "" "" "" "" "" "" "263.1" "256.6" "260.5" "233.6" "260.8" "278.3" "271.4" "258.2" "288.1" "273.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4811509789942253503" "False" "High" "IsMasterProtein" "Q7Z6M1" "Rab9 effector protein with kelch motifs OS=Homo sapiens OX=9606 GN=RABEPK PE=1 SV=1" "0.000" "False" "16.961" "16" "5" "5" "5" "372" "40.5" "6.25" "16.90" "5" "transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01344, Pf07646, Pf13415" "10244" "ENSG00000136933" "RABEPK" "A8K403; hsa:10244; O00568; Q69YR2; Q6FHA4; Q6IBG7; Q6P092; Q7Z6M1; Q86Y76; Q9BWB1" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "0.887" "0.885" "0.914" "0.872" "0.945" "0.950" "0.903" "0.909" "0.883" "570.0" "505.4" "504.6" "521.1" "496.8" "538.6" "541.7" "514.6" "518.0" "503.2" "" "" "" "" "" "" "" "" "" "" "534.1" "418.2" "468.4" "402.8" "423.5" "514.5" "494.9" "456.9" "518.0" "484.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2558659697255910600" "False" "High" "IsMasterProtein" "Q92747" "Actin-related protein 2/3 complex subunit 1A OS=Homo sapiens OX=9606 GN=ARPC1A PE=1 SV=2" "0.000" "False" "16.958" "13" "6" "10" "6" "370" "41.5" "8.18" "26.14" "6" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00400" "10552" "ENSG00000241685" "ARPC1A" "A4D276; B4DLQ7; D6W5S1; hsa:10552; Q7Z5U8; Q86WU5; Q8IXQ0; Q92747" "Pathogenic Escherichia coli infection" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Clathrin-mediated endocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling" "6" "0" "1.111" "1.042" "1.173" "1.033" "0.981" "0.980" "1.020" "0.989" "1.007" "959.1" "1065.8" "999.2" "1125.1" "990.4" "940.9" "939.9" "978.0" "949.0" "965.5" "" "" "" "" "" "" "" "" "" "" "898.7" "881.9" "927.7" "869.8" "844.2" "899.0" "858.9" "868.4" "949.0" "929.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2305631654265975414" "False" "High" "IsMasterProtein" "Q96E11" "Ribosome-recycling factor, mitochondrial OS=Homo sapiens OX=9606 GN=MRRF PE=1 SV=1" "0.000" "False" "16.947" "23" "5" "6" "5" "262" "29.3" "9.79" "17.37" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "translation activity" "Pf01765" "92399" "ENSG00000148187" "MRRF" "A8K6D8; A8K6Z4; B7Z4X5; B7Z6P7; hsa:92399; Q5RKT1; Q5T7T0; Q5T7T1; Q5T7T2; Q5T7T3; Q5T7T4; Q5T7T5; Q96E11" "" "Mitochondrial translation termination" "1" "0" "0.993" "0.985" "1.019" "1.009" "1.038" "0.973" "1.061" "1.037" "0.990" "907.5" "901.6" "893.7" "924.5" "915.6" "941.7" "883.4" "962.7" "941.2" "898.7" "" "" "" "" "" "" "" "" "" "" "850.4" "746.1" "829.6" "714.7" "780.4" "899.7" "807.2" "854.8" "941.2" "865.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3091495107374211726" "False" "High" "IsMasterProtein" "Q9H501" "ESF1 homolog OS=Homo sapiens OX=9606 GN=ESF1 PE=1 SV=1" "0.000" "False" "16.944" "7" "7" "9" "7" "851" "98.7" "5.11" "25.29" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf08159" "51575" "ENSG00000089048" "ESF1" "hsa:51575; Q86X92; Q9H501; Q9H9Q5; Q9HA35; Q9NX93; Q9P1S6" "" "" "0" "0" "1.063" "1.094" "1.159" "1.193" "1.169" "1.345" "1.429" "1.325" "1.215" "972.3" "1033.3" "1064.0" "1126.7" "1160.4" "1137.0" "1307.5" "1389.4" "1287.9" "1181.2" "" "" "" "" "" "" "" "" "" "" "911.1" "855.1" "987.8" "871.0" "989.1" "1086.3" "1194.7" "1233.6" "1287.9" "1137.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2222820814571899525" "False" "High" "IsMasterProtein" "Q9UJ70" "N-acetyl-D-glucosamine kinase OS=Homo sapiens OX=9606 GN=NAGK PE=1 SV=4" "0.000" "False" "16.943" "19" "6" "8" "6" "344" "37.4" "6.24" "20.45" "6" "other metabolic processes;stress response;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf01869" "55577" "ENSG00000124357" "NAGK" "B4DLZ5; hsa:55577; Q53HD5; Q6IA84; Q9BS29; Q9BVP0; Q9NV37; Q9UJ70" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "0" "0.968" "0.980" "1.043" "0.964" "0.939" "0.993" "0.913" "0.972" "0.944" "586.4" "567.4" "574.7" "611.5" "565.4" "550.8" "582.5" "535.1" "570.1" "553.8" "" "" "" "" "" "" "" "" "" "" "549.4" "469.5" "533.6" "472.8" "482.0" "526.2" "532.2" "475.2" "570.1" "533.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1761258682097812184" "False" "High" "IsMasterProtein" "Q9NS86" "LanC-like protein 2 OS=Homo sapiens OX=9606 GN=LANCL2 PE=1 SV=1" "0.000" "False" "16.937" "12" "5" "5" "5" "450" "50.8" "7.43" "17.99" "5" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf05147" "55915" "ENSG00000132434" "LANCL2" "B2R8D4; hsa:55915; Q6NSL4; Q8TCQ3; Q9BSR1; Q9NS86" "" "" "0" "0" "1.023" "1.034" "0.992" "1.047" "0.998" "0.982" "1.012" "1.031" "0.978" "836.5" "855.6" "865.4" "829.7" "875.8" "834.9" "821.4" "846.5" "862.9" "818.4" "" "" "" "" "" "" "" "" "" "" "783.8" "708.0" "803.4" "641.4" "746.5" "797.6" "750.5" "751.6" "862.9" "788.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3114131480513419355" "False" "High" "IsMasterProtein" "P62701" "Small ribosomal subunit protein eS4, X isoform OS=Homo sapiens OX=9606 GN=RPS4X PE=1 SV=2" "0.000" "False" "16.933" "22" "7" "9" "7" "263" "29.6" "10.15" "28.04" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00467, Pf00900, Pf08071, Pf16121" "6191" "ENSG00000198034" "RPS4X" "hsa:6191; P12631; P12750; P27576; P55831; P62701; Q14727; Q6IPY4" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "1.031" "0.995" "1.020" "1.067" "1.033" "1.111" "1.190" "1.037" "1.013" "1271.9" "1310.9" "1265.4" "1297.8" "1357.4" "1313.8" "1412.7" "1513.3" "1319.1" "1288.4" "" "" "" "" "" "" "" "" "" "" "1191.8" "1084.8" "1174.8" "1003.3" "1157.0" "1255.2" "1290.8" "1343.7" "1319.1" "1240.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5610453000666898366" "False" "High" "IsMasterProtein" "Q6RFH5" "WD repeat-containing protein 74 OS=Homo sapiens OX=9606 GN=WDR74 PE=1 SV=1" "0.000" "False" "16.921" "18" "6" "6" "6" "385" "42.4" "8.32" "17.11" "6" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "54663" "ENSG00000133316" "WDR74" "A8K8G5; hsa:54663; Q6RFH5; Q9BRC9; Q9H6X8; Q9NVY2" "" "" "0" "0" "1.105" "1.088" "1.167" "1.155" "1.083" "1.166" "1.158" "1.086" "1.058" "530.4" "585.9" "577.3" "619.1" "612.6" "574.1" "618.3" "614.1" "576.1" "561.1" "" "" "" "" "" "" "" "" "" "" "496.9" "484.9" "535.9" "478.6" "522.2" "548.5" "564.9" "545.3" "576.1" "540.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4528933939237155494" "False" "High" "IsMasterProtein" "P25490" "Transcriptional repressor protein YY1 OS=Homo sapiens OX=9606 GN=YY1 PE=1 SV=2" "0.000" "False" "16.919" "14" "6" "8" "6" "414" "44.7" "6.25" "30.99" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "7528" "ENSG00000100811" "YY1" "hsa:7528; P25490; Q14935" "Sterol regulatory element-binding proteins (SREBP) signaling; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Pleural mesothelioma" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; UCH proteinases; DNA Damage Recognition in GG-NER; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors" "8" "0" "0.983" "0.944" "0.916" "0.954" "0.972" "0.861" "0.956" "0.962" "0.949" "1080.1" "1061.4" "1019.9" "989.1" "1030.6" "1050.0" "929.6" "1032.5" "1039.3" "1025.2" "" "" "" "" "" "" "" "" "" "" "1012.0" "878.3" "946.8" "764.6" "878.5" "1003.2" "849.4" "916.7" "1039.3" "987.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2081784358139501247" "False" "High" "IsMasterProtein" "Q96ME1" "F-box/LRR-repeat protein 18 OS=Homo sapiens OX=9606 GN=FBXL18 PE=1 SV=3" "0.000" "False" "16.877" "8" "5" "7" "5" "718" "78.9" "8.27" "23.19" "5" "protein metabolism;other metabolic processes" "cytosol;other cell component" "" "Pf12937, Pf19729" "80028" "ENSG00000155034" "FBXL18" "A0A024R857; B3KTC9; B4DH63; H0Y6I6; hsa:80028; Q96ME1; Q9BR90; Q9BTC7; Q9HAK7" "" "Antigen processing: Ubiquitination & Proteasome degradation; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Neddylation" "3" "0" "1.068" "0.992" "0.982" "1.059" "1.043" "1.003" "1.018" "0.995" "1.018" "490.7" "524.2" "486.7" "482.0" "519.4" "511.9" "492.2" "499.7" "488.3" "499.4" "" "" "" "" "" "" "" "" "" "" "459.8" "433.7" "451.9" "372.6" "442.8" "489.1" "449.8" "443.7" "488.3" "480.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6174880606405183757" "False" "High" "IsMasterProtein" "P56545" "C-terminal-binding protein 2 OS=Homo sapiens OX=9606 GN=CTBP2 PE=1 SV=1" "0.000" "False" "16.873" "11" "6" "11" "2" "445" "48.9" "6.95" "35.15" "6" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00389, Pf02826" "1488" "ENSG00000175029" "CTBP2" "A8K2X5; D3DRF5; hsa:1488; O43449; P56545; Q5SQP7; Q69YI3; Q86SV0; Q8IY44; Q9H2T8" "Neural crest differentiation; Notch signaling; Mesodermal commitment pathway; Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Pleural mesothelioma" "Repression of WNT target genes; Signaling by TCF7L2 mutants" "11" "0" "1.014" "0.987" "1.137" "0.978" "0.992" "0.986" "1.016" "0.988" "0.974" "534.4" "541.7" "527.3" "607.6" "522.5" "530.1" "527.0" "543.2" "527.9" "520.7" "" "" "" "" "" "" "" "" "" "" "500.7" "448.3" "489.5" "469.7" "445.4" "506.4" "481.5" "482.3" "527.9" "501.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6251688870276858346" "False" "High" "IsMasterProtein" "Q9BX40" "Protein LSM14 homolog B OS=Homo sapiens OX=9606 GN=LSM14B PE=1 SV=1" "0.000" "False" "16.861" "16" "5" "6" "5" "385" "42.0" "9.69" "22.78" "5" "other biological processes" "other cell component" "nucleic acid binding activity" "Pf09532, Pf12701" "149986" "ENSG00000149657" "LSM14B" "hsa:149986; Q6PFW8; Q96LH8; Q9BX40" "" "" "0" "0" "1.103" "1.148" "1.080" "1.146" "1.087" "1.182" "1.162" "1.143" "1.167" "410.2" "452.4" "470.8" "443.2" "470.1" "445.8" "484.9" "476.5" "469.0" "478.7" "" "" "" "" "" "" "" "" "" "" "384.3" "374.4" "437.1" "342.6" "400.7" "425.9" "443.1" "423.1" "469.0" "461.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6836769617334137947" "False" "High" "IsMasterProtein" "Q96LA8" "Protein arginine N-methyltransferase 6 OS=Homo sapiens OX=9606 GN=PRMT6 PE=1 SV=1" "0.000" "False" "16.856" "14" "4" "5" "4" "375" "41.9" "5.44" "21.05" "4" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf13649" "55170" "ENSG00000198890" "PRMT6" "A3KME1; B4DID8; hsa:55170; Q5T5Y5; Q6DKI4; Q96LA8; Q9NVR8" "Male infertility; Nitric oxide metabolism in cystic fibrosis" "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RMTs methylate histone arginines" "4" "0" "0.920" "1.019" "1.063" "0.909" "0.845" "0.988" "0.858" "0.890" "0.929" "280.1" "257.7" "285.3" "297.7" "254.8" "236.7" "276.8" "240.3" "249.4" "260.2" "" "" "" "" "" "" "" "" "" "" "262.5" "213.2" "264.9" "230.1" "217.2" "226.2" "252.9" "213.4" "249.4" "250.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "996701164361086035" "False" "High" "IsMasterProtein" "Q96E29" "Transcription termination factor 3, mitochondrial OS=Homo sapiens OX=9606 GN=MTERF3 PE=1 SV=2" "0.000" "False" "16.833" "13" "6" "6" "6" "417" "47.9" "8.53" "17.36" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion" "nucleic acid binding activity" "Pf02536" "51001" "ENSG00000156469" "MTERF3" "B3KMG6; G3V130; hsa:51001; Q96E29; Q9Y301" "Mitochondrial gene expression" "PINK1-PRKN Mediated Mitophagy" "2" "0" "1.019" "1.136" "1.119" "1.112" "1.159" "1.151" "1.179" "1.081" "1.105" "681.1" "694.2" "773.4" "761.8" "757.4" "789.6" "783.8" "802.9" "736.2" "752.9" "" "" "" "" "" "" "" "" "" "" "638.2" "574.4" "718.0" "588.9" "645.6" "754.4" "716.2" "712.9" "736.2" "724.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7690147936594120282" "False" "High" "IsMasterProtein" "P08397" "Porphobilinogen deaminase OS=Homo sapiens OX=9606 GN=HMBS PE=1 SV=2" "0.000" "False" "16.829" "14" "7" "7" "7" "361" "39.3" "7.18" "22.02" "7" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01379, Pf03900" "3145" "ENSG00000256269" "HMBS" "A8K2L0; G3V1P4; G5EA58; hsa:3145; P08396; P08397; Q16012" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "3" "0" "0.975" "0.993" "0.991" "0.955" "0.942" "0.954" "0.973" "0.968" "0.916" "683.9" "666.6" "678.8" "677.6" "653.0" "644.4" "652.2" "665.3" "661.9" "626.7" "" "" "" "" "" "" "" "" "" "" "640.8" "551.6" "630.2" "523.8" "556.6" "615.6" "596.0" "590.7" "661.9" "603.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "538564902379484332" "False" "High" "IsMasterProtein" "P49815" "Tuberin OS=Homo sapiens OX=9606 GN=TSC2 PE=1 SV=2" "0.000" "False" "16.827" "3" "6" "6" "6" "1807" "200.5" "7.31" "16.52" "6" "stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf02145, Pf03542, Pf11864" "7249" "ENSG00000103197" "TSC2" "A7E2E2; B4DIL8; B4DIQ7; B4DRN2; B7Z2B8; C9J378; hsa:7249; O75275; P49815; Q4LE71; Q8TAZ1" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Follicle stimulating hormone (FSH) signaling pathway; Glioblastoma signaling pathways; Brain-derived neurotrophic factor (BDNF) signaling pathway; Nanoparticle triggered autophagic cell death; Polycystic kidney disease pathway; Wnt signaling pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; ATM signaling in development and disease ; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; p53 transcriptional gene network; Pleural mesothelioma; DYRK1A involvement regarding cell proliferation in brain development; Primary ovarian insufficiency; Monoamine transport" "Macroautophagy; Constitutive Signaling by AKT1 E17K in Cancer; TP53 Regulates Metabolic Genes; AKT phosphorylates targets in the cytosol; Energy dependent regulation of mTOR by LKB1-AMPK; TBC/RABGAPs; Inhibition of TSC complex formation by PKB" "35" "0" "1.114" "1.054" "1.032" "0.971" "1.004" "0.818" "0.912" "1.568" "1.191" "185.5" "206.6" "195.6" "191.4" "180.2" "186.3" "151.9" "169.3" "290.8" "221.0" "" "" "" "" "" "" "" "" "" "" "173.8" "171.0" "181.6" "148.0" "153.6" "178.0" "138.8" "150.3" "290.8" "212.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3113703590403153606" "False" "High" "IsMasterProtein" "Q96EP5" "DAZ-associated protein 1 OS=Homo sapiens OX=9606 GN=DAZAP1 PE=1 SV=1" "0.000" "False" "16.819" "13" "4" "5" "4" "407" "43.4" "8.56" "18.03" "4" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "26528" "ENSG00000071626" "DAZAP1" "hsa:26528; Q96EP5; Q96MJ3; Q9NRR9" "" "" "0" "0" "1.364" "0.930" "1.158" "1.082" "0.961" "0.958" "0.909" "1.237" "1.088" "207.2" "282.7" "192.7" "240.0" "224.2" "199.0" "198.5" "188.3" "256.4" "225.4" "" "" "" "" "" "" "" "" "" "" "194.2" "233.9" "178.9" "185.5" "191.1" "190.2" "181.4" "167.2" "256.4" "217.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6910881260683280979" "False" "High" "IsMasterProtein" "Q9UEE9" "Craniofacial development protein 1 OS=Homo sapiens OX=9606 GN=CFDP1 PE=1 SV=1" "0.000" "False" "16.806" "20" "6" "9" "6" "299" "33.6" "4.81" "25.19" "6" "cell adhesion;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf07572" "10428" "ENSG00000153774" "CFDP1" "hsa:10428; O00393; O00404; Q9UEE9; Q9UEF0; Q9UEF1; Q9UEF8" "" "" "0" "0" "1.083" "0.988" "1.083" "1.036" "0.975" "1.043" "1.004" "0.977" "0.970" "1025.4" "1110.6" "1013.2" "1110.1" "1062.1" "999.3" "1069.1" "1029.7" "1001.8" "994.9" "" "" "" "" "" "" "" "" "" "" "960.8" "919.0" "940.7" "858.2" "905.3" "954.8" "976.9" "914.3" "1001.8" "957.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4160171774517724011" "False" "High" "IsMasterProtein" "P51452" "Dual specificity protein phosphatase 3 OS=Homo sapiens OX=9606 GN=DUSP3 PE=1 SV=1" "0.000" "False" "16.797" "30" "5" "6" "5" "185" "20.5" "7.80" "20.41" "5" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00782" "1845" "ENSG00000108861" "DUSP3" "D3DX45; hsa:1845; P51452; Q5U0J1; Q8IYJ9" "MAPK signaling pathway; Fragile X syndrome" "ERKs are inactivated" "3" "0" "1.059" "1.059" "1.165" "1.058" "1.039" "1.089" "1.025" "1.059" "1.047" "715.5" "758.0" "758.0" "833.7" "757.3" "743.5" "779.2" "733.1" "757.8" "749.0" "" "" "" "" "" "" "" "" "" "" "670.4" "627.3" "703.7" "644.5" "645.5" "710.4" "711.9" "650.9" "757.8" "721.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4459716120349710015" "False" "High" "IsMasterProtein" "O14545" "TRAF-type zinc finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=TRAFD1 PE=1 SV=1" "0.000" "False" "16.786" "9" "5" "5" "5" "582" "64.8" "5.29" "16.76" "5" "other biological processes" "mitochondrion" "other molecular function" "Pf21366" "10906" "ENSG00000135148" "TRAFD1" "A8K5L6; B4DI89; hsa:10906; O14545" "" "" "0" "0" "1.084" "0.969" "1.040" "1.027" "1.003" "1.033" "1.042" "1.021" "1.026" "423.3" "458.8" "410.3" "440.4" "434.6" "424.7" "437.5" "440.9" "432.2" "434.5" "" "" "" "" "" "" "" "" "" "" "396.6" "379.7" "380.9" "340.5" "370.5" "405.7" "399.7" "391.5" "432.2" "418.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5620405547330282270" "False" "High" "IsMasterProtein" "Q7Z4V5" "Hepatoma-derived growth factor-related protein 2 OS=Homo sapiens OX=9606 GN=HDGFL2 PE=1 SV=1" "0.000" "False" "16.785" "8" "8" "12" "6" "671" "74.3" "7.49" "32.77" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00855, Pf11467" "84717" "ENSG00000167674" "HDGFL2" "I3L080; K7EQZ6; Q7Z4V5; Q96GI5; Q9BW08" "" "" "0" "0" "1.003" "1.019" "1.049" "1.062" "1.042" "1.338" "1.332" "1.264" "1.113" "671.0" "673.2" "683.9" "703.8" "712.2" "699.4" "897.6" "893.6" "847.8" "746.5" "" "" "" "" "" "" "" "" "" "" "628.7" "557.1" "634.9" "544.1" "607.1" "668.2" "820.2" "793.4" "847.8" "718.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9085174644749999284" "False" "High" "IsMasterProtein" "Q4G0F5" "Vacuolar protein sorting-associated protein 26B OS=Homo sapiens OX=9606 GN=VPS26B PE=1 SV=2" "0.000" "False" "16.780" "21" "6" "6" "5" "336" "39.1" "7.36" "21.17" "6" "stress response;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf03643" "112936" "ENSG00000151502" "VPS26B" "hsa:112936; Q4G0F5; Q96A55" "" "" "0" "0" "1.074" "1.063" "1.071" "1.000" "1.122" "1.004" "1.050" "1.127" "1.051" "293.8" "315.6" "312.3" "314.8" "293.9" "329.5" "294.9" "308.4" "331.1" "308.9" "" "" "" "" "" "" "" "" "" "" "275.3" "261.1" "289.9" "243.3" "250.5" "314.8" "269.4" "273.8" "331.1" "297.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4327969175985067622" "False" "High" "IsMasterProtein" "Q6I9Y2" "THO complex subunit 7 homolog OS=Homo sapiens OX=9606 GN=THOC7 PE=1 SV=3" "0.000" "False" "16.780" "30" "6" "9" "6" "204" "23.7" "5.67" "27.60" "6" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05615" "80145" "ENSG00000163634" "THOC7" "hsa:80145; Q6I9Y2; Q6P1L3; Q8WUF2; Q9H5H0" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "1.170" "1.063" "1.224" "1.191" "1.179" "1.303" "1.354" "1.170" "1.134" "277.0" "324.2" "294.6" "339.1" "330.0" "326.7" "360.9" "375.1" "324.1" "314.2" "" "" "" "" "" "" "" "" "" "" "259.6" "268.3" "273.5" "262.1" "281.3" "312.1" "329.7" "333.1" "324.1" "302.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4340156669496060526" "False" "High" "IsMasterProtein" "Q9Y3C6" "Peptidyl-prolyl cis-trans isomerase-like 1 OS=Homo sapiens OX=9606 GN=PPIL1 PE=1 SV=1" "0.000" "False" "16.775" "40" "6" "10" "6" "166" "18.2" "7.99" "23.55" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "other molecular function" "Pf00160" "51645" "ENSG00000137168" "PPIL1" "hsa:51645; O15001; Q5TDC9; Q9Y3C6" "" "mRNA Splicing - Major Pathway" "1" "0" "1.033" "1.016" "1.025" "1.048" "1.021" "1.055" "1.058" "1.139" "1.071" "877.6" "906.9" "891.2" "899.9" "919.8" "896.0" "926.1" "928.6" "999.5" "939.9" "" "" "" "" "" "" "" "" "" "" "822.3" "750.4" "827.4" "695.7" "784.1" "856.1" "846.2" "824.5" "999.5" "905.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7795104145569461525" "False" "High" "IsMasterProtein" "Q2M389" "WASH complex subunit 4 OS=Homo sapiens OX=9606 GN=WASHC4 PE=1 SV=2" "0.000" "False" "16.762" "4" "6" "7" "6" "1173" "136.3" "7.44" "19.21" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "" "Pf14744, Pf14745, Pf14746" "23325" "ENSG00000136051" "WASHC4" "hsa:23325; Q2M389; Q2NL83; Q8IW61; Q8N5W7; Q9NVD6; Q9UPW7" "" "" "0" "0" "1.021" "0.962" "1.025" "0.973" "0.981" "0.981" "0.911" "0.941" "0.948" "504.5" "515.0" "485.5" "517.1" "490.6" "494.9" "494.7" "459.5" "474.9" "478.2" "" "" "" "" "" "" "" "" "" "" "472.7" "426.2" "450.7" "399.7" "418.2" "472.8" "452.0" "408.0" "474.9" "460.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5750940690254382676" "False" "High" "IsMasterProtein" "P16333" "SH2/SH3 adapter protein NCK1 OS=Homo sapiens OX=9606 GN=NCK1 PE=1 SV=1" "0.000" "False" "16.751" "19" "6" "7" "4" "377" "42.8" "6.47" "23.93" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018" "4690" "ENSG00000158092" "NCK1" "B7Z751; D3DNE3; hsa:4690; P16333" "Pathogenic Escherichia coli infection; B cell receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway; Genes controlling nephrogenesis; GDNF signaling; ErbB signaling pathway; T-cell receptor signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Generation of second messenger molecules; RHO GTPases Activate WASPs and WAVEs; PKR-mediated signaling; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; DCC mediated attractive signaling; Downstream signal transduction; VEGFA-VEGFR2 Pathway; Activation of RAC1" "27" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8881976693439910842" "False" "High" "IsMasterProtein" "P40306" "Proteasome subunit beta type-10 OS=Homo sapiens OX=9606 GN=PSMB10 PE=1 SV=1" "0.000" "False" "16.743" "21" "5" "7" "5" "273" "28.9" "7.81" "24.19" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf12465" "5699" "ENSG00000205220" "PSMB10" "B2R5J4; hsa:5699; P40306; Q5U098" "Proteasome degradation" "Regulation of PTEN stability and activity; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; FCERI mediated NF-kB activation; Downstream TCR signaling; Regulation of RAS by GAPs; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "60" "0" "0.896" "0.956" "0.877" "0.863" "0.902" "0.878" "0.928" "0.868" "0.890" "1517.9" "1359.7" "1451.4" "1331.8" "1309.9" "1369.2" "1332.6" "1408.5" "1318.1" "1350.8" "" "" "" "" "" "" "" "" "" "" "1422.2" "1125.1" "1347.5" "1029.6" "1116.5" "1308.2" "1217.6" "1250.6" "1318.1" "1300.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4697370261215889932" "False" "High" "IsMasterProtein" "O43583" "Density-regulated protein OS=Homo sapiens OX=9606 GN=DENR PE=1 SV=2" "0.000" "False" "16.741" "29" "5" "9" "5" "198" "22.1" "5.30" "31.60" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "nucleic acid binding activity" "Pf01253, Pf21023" "8562" "ENSG00000139726" "DENR" "hsa:8562; O43583; Q9H3U6; Q9UKZ0" "" "" "0" "0" "1.008" "0.978" "0.957" "0.982" "0.979" "0.987" "1.002" "0.905" "0.964" "2091.5" "2109.2" "2046.5" "2001.4" "2053.9" "2048.2" "2063.9" "2096.1" "1892.7" "2016.5" "" "" "" "" "" "" "" "" "" "" "1959.7" "1745.3" "1899.9" "1547.2" "1750.7" "1956.9" "1885.9" "1861.1" "1892.7" "1941.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8750059555873910244" "False" "High" "IsMasterProtein" "Q96KB5" "Lymphokine-activated killer T-cell-originated protein kinase OS=Homo sapiens OX=9606 GN=PBK PE=1 SV=3" "0.000" "False" "16.729" "17" "6" "9" "6" "322" "36.1" "5.12" "25.19" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "kinase activity;other molecular function" "Pf00069" "55872" "ENSG00000168078" "PBK" "B4DX68; D3DST2; hsa:55872; Q96KB5; Q9NPD9; Q9NYL7; Q9NZK6" "4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling" "" "2" "0" "0.961" "0.976" "0.941" "0.947" "0.955" "0.918" "0.939" "0.925" "0.948" "1391.2" "1337.6" "1357.4" "1308.7" "1316.8" "1327.9" "1277.5" "1306.0" "1286.2" "1318.8" "" "" "" "" "" "" "" "" "" "" "1303.5" "1106.8" "1260.2" "1011.7" "1122.4" "1268.6" "1167.3" "1159.6" "1286.2" "1269.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7321680242331923571" "False" "High" "IsMasterProtein" "Q96EI5" "Transcription elongation factor A protein-like 4 OS=Homo sapiens OX=9606 GN=TCEAL4 PE=1 SV=2" "0.000" "False" "16.721" "31" "6" "8" "6" "215" "24.6" "5.20" "23.26" "6" "" "nucleus" "" "Pf04538" "79921" "ENSG00000133142" "TCEAL4" "hsa:79921; Q8WY12; Q96EI5; Q9H2H1; Q9H775" "" "" "0" "0" "1.050" "1.026" "1.036" "1.015" "1.032" "0.999" "0.991" "1.003" "1.048" "405.0" "425.1" "415.6" "419.7" "411.2" "418.0" "404.7" "401.3" "406.0" "424.5" "" "" "" "" "" "" "" "" "" "" "379.4" "351.8" "385.8" "324.5" "350.5" "399.4" "369.8" "356.3" "406.0" "408.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7252282534917135675" "False" "High" "IsMasterProtein" "Q15542" "Transcription initiation factor TFIID subunit 5 OS=Homo sapiens OX=9606 GN=TAF5 PE=1 SV=3" "0.000" "False" "16.717" "7" "6" "7" "6" "800" "86.8" "5.64" "17.04" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400, Pf04494" "6877" "ENSG00000148835" "TAF5" "A8K5B4; B2RMR0; B7ZKJ6; hsa:6877; Q15542; Q53EM4; Q5SYD5; Q86UZ7; Q9Y4K5" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "11" "0" "1.011" "1.043" "1.109" "1.026" "1.008" "1.085" "1.069" "1.017" "1.039" "1156.7" "1169.9" "1206.4" "1283.0" "1187.2" "1165.7" "1255.4" "1236.4" "1176.0" "1202.0" "" "" "" "" "" "" "" "" "" "" "1083.8" "968.1" "1120.0" "991.8" "1012.0" "1113.7" "1147.1" "1097.8" "1176.0" "1157.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4497117085705849008" "False" "High" "IsMasterProtein" "Q9UHY1" "Nuclear receptor-binding protein OS=Homo sapiens OX=9606 GN=NRBP1 PE=1 SV=1" "0.000" "False" "16.713" "13" "5" "5" "5" "535" "59.8" "5.08" "19.67" "5" "transport" "other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf07714" "29959" "ENSG00000115216" "NRBP1" "B3KV40; D6W558; hsa:29959; Q53FZ5; Q96SU3; Q9UHY1" "" "Nuclear Receptor transcription pathway" "1" "0" "0.993" "1.014" "1.084" "1.038" "1.003" "1.050" "0.993" "1.009" "1.040" "428.7" "425.9" "434.9" "464.5" "445.0" "429.7" "450.1" "425.7" "432.5" "445.7" "" "" "" "" "" "" "" "" "" "" "401.7" "352.4" "403.7" "359.1" "379.3" "410.6" "411.3" "378.0" "432.5" "429.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5667017434232915728" "False" "High" "IsMasterProtein" "Q9Y618" "Nuclear receptor corepressor 2 OS=Homo sapiens OX=9606 GN=NCOR2 PE=1 SV=3" "0.000" "False" "16.705" "2" "7" "7" "5" "2514" "273.5" "7.59" "20.01" "7" "transport;developmental processes;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00249, Pf15784" "9612" "ENSG00000196498" "NCOR2" "hsa:9612; O00613; O15416; O15421; Q13354; Q56D06; Q59GM0; Q9Y5U0; Q9Y618" "Androgen receptor signaling pathway; Adipogenesis; Aryl hydrocarbon receptor pathway; Notch signaling; Rett syndrome; Notch signaling pathway" "Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; SUMOylation of transcription cofactors; HCMV Early Events; Nuclear Receptor transcription pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HDACs deacetylate histones; Cytoprotection by HMOX1; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis" "23" "0" "1.022" "0.977" "1.022" "0.997" "1.031" "1.006" "0.987" "0.917" "0.964" "632.0" "646.3" "617.6" "645.7" "630.0" "651.6" "635.8" "623.9" "579.8" "609.6" "" "" "" "" "" "" "" "" "" "" "592.2" "534.8" "573.4" "499.1" "537.0" "622.5" "581.0" "553.9" "579.8" "586.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7112262159952005485" "False" "High" "IsMasterProtein" "Q5T440" "Putative transferase CAF17, mitochondrial OS=Homo sapiens OX=9606 GN=IBA57 PE=1 SV=1" "0.000" "False" "16.696" "20" "5" "6" "5" "356" "38.1" "9.83" "21.16" "5" "cell organization and biogenesis;other metabolic processes" "mitochondrion" "other molecular function" "" "200205" "ENSG00000181873" "IBA57" "hsa:200205; Q5T440" "" "" "0" "0" "1.065" "1.135" "1.014" "1.059" "1.160" "0.952" "1.026" "1.090" "1.166" "180.5" "192.1" "204.7" "182.9" "191.2" "209.3" "171.9" "185.1" "196.8" "210.4" "" "" "" "" "" "" "" "" "" "" "169.1" "159.0" "190.1" "141.4" "163.0" "200.0" "157.1" "164.4" "196.8" "202.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8237731062455566207" "False" "High" "IsMasterProtein" "P40763" "Signal transducer and activator of transcription 3 OS=Homo sapiens OX=9606 GN=STAT3 PE=1 SV=2" "0.000" "False" "16.696" "7" "6" "6" "6" "770" "88.0" "6.30" "19.85" "6" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf21354" "6774" "ENSG00000168610" "STAT3" "A8K7B8; hsa:6774; K7ENL3; O14916; P40763; Q9BW54" "IL-5 signaling pathway; Androgen receptor signaling pathway; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Cell differentiation - expanded index; Cell differentiation - index; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; IL-7 signaling pathway; IL-17 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; AGE/RAGE pathway; Interleukin-11 signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Involution (Stage 4 of 4); Dopaminergic neurogenesis; IL-3 signaling pathway; TCA cycle nutrient use and invasiveness of ovarian cancer; Estrogen receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; Development of pulmonary dendritic cells and macrophage subsets; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Leptin-insulin signaling overlap; IL-4 signaling pathway; PDGFR-beta pathway; Prion disease pathway; Clear cell renal cell carcinoma pathways; MET in type 1 papillary renal cell carcinoma; Non-small cell lung cancer; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Extracellular vesicles in the crosstalk of cardiac cells; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; EGF/EGFR signaling pathway; IL-10 anti-inflammatory signaling pathway ; Regulatory circuits of the STAT3 signaling pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Neural crest cell migration during development; Neural crest cell migration in cancer; Cancer immunotherapy by PD-1 blockade; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; TGF-beta receptor signaling in skeletal dysplasias; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Th17 cell differentiation pathway; Urotensin-II-mediated signaling pathway; Inflammatory bowel disease signaling; 2q11.2 copy number variation syndrome; 2q21.1 copy number variation syndrome; Neurogenesis regulation in the olfactory epithelium; Acute myeloid leukemia; Autophagy in pancreatic ductal adenocarcinoma; IL-26 signaling pathways; JAK-STAT signaling in the regulation of beta cells; TAR syndrome; Osteoarthritic chondrocyte hypertrophy; IL-19 signaling pathway; TGF-beta receptor signaling; EPO receptor signaling; Interferon type I signaling pathways; Notch signaling pathway; Serotonin HTR1 group and FOS pathway" "Downstream signal transduction; Transcriptional regulation of granulopoiesis; Interleukin-4 and Interleukin-13 signaling; Senescence-Associated Secretory Phenotype (SASP); PKR-mediated signaling; Signaling by ALK fusions and activated point mutants; Interleukin-7 signaling; Signaling by SCF-KIT; Signaling by ALK; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Cytoprotection by HMOX1; Association of TriC/CCT with target proteins during biosynthesis; Interleukin-10 signaling; Growth hormone receptor signaling; Interleukin-6 signaling; Signaling by Leptin; PTK6 Activates STAT3; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; Signaling by CSF1 (M-CSF) in myeloid cells; STAT3 nuclear events downstream of ALK signaling; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-23 signaling; Interleukin-27 signaling; Interleukin-37 signaling; Signalling to STAT3; Nuclear events stimulated by ALK signaling in cancer; MET activates STAT3; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling" "119" "0" "0.980" "1.083" "1.062" "1.054" "0.995" "0.990" "0.865" "0.931" "1.031" "917.1" "898.9" "993.2" "973.8" "967.0" "912.6" "907.8" "793.0" "853.9" "945.2" "" "" "" "" "" "" "" "" "" "" "859.3" "743.8" "922.1" "752.8" "824.3" "871.9" "829.5" "704.1" "853.9" "910.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2890344552958539961" "False" "High" "IsMasterProtein" "O75569" "Interferon-inducible double-stranded RNA-dependent protein kinase activator A OS=Homo sapiens OX=9606 GN=PRKRA PE=1 SV=1" "0.000" "False" "16.682" "24" "7" "8" "7" "313" "34.4" "8.41" "20.52" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00035" "8575" "ENSG00000180228" "PRKRA" "A8K3I6; hsa:8575; O75569; Q53G24; Q6X7T5; Q8NDK4" "VEGFA-VEGFR2 signaling; Ebola virus infection in host" "PKR-mediated signaling; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis" "5" "0" "1.036" "1.001" "0.971" "0.976" "0.994" "0.922" "0.944" "0.956" "1.032" "908.3" "941.5" "909.4" "881.9" "886.9" "902.9" "837.9" "857.7" "868.2" "937.4" "" "" "" "" "" "" "" "" "" "" "851.1" "779.0" "844.3" "681.7" "756.0" "862.6" "765.6" "761.5" "868.2" "902.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4782042828393349132" "False" "High" "IsMasterProtein" "P52756" "RNA-binding protein 5 OS=Homo sapiens OX=9606 GN=RBM5 PE=1 SV=2" "0.000" "False" "16.670" "7" "6" "7" "4" "815" "92.1" "6.28" "24.01" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641, Pf01585, Pf17780" "10181" "ENSG00000003756" "RBM5" "B2RA45; B4DM16; B4DMF9; B4DZ63; hsa:10181; P52756; Q93021; Q9BU14; Q9HDA6; Q9UKY8; Q9UL24" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.112" "1.145" "1.301" "1.247" "1.104" "1.505" "1.382" "1.340" "1.247" "215.3" "239.5" "246.6" "280.2" "268.5" "237.8" "324.1" "297.5" "288.6" "268.5" "" "" "" "" "" "" "" "" "" "" "201.8" "198.2" "229.0" "216.6" "228.9" "227.2" "296.2" "264.2" "288.6" "258.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8377264718886898276" "False" "High" "IsMasterProtein" "Q9Y2K7" "Lysine-specific demethylase 2A OS=Homo sapiens OX=9606 GN=KDM2A PE=1 SV=3" "0.000" "False" "16.666" "5" "5" "6" "5" "1162" "132.7" "7.58" "17.38" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00646, Pf02008, Pf16866, Pf17811" "22992" "ENSG00000173120" "KDM2A" "D4QA03; E9PIL6; hsa:22992; I3VM55; Q49A21; Q4G0M3; Q69YY8; Q9BVH5; Q9H7H5; Q9UK66; Q9Y2K7" "" "HDMs demethylate histones" "1" "0" "1.035" "0.984" "1.095" "1.036" "0.975" "0.906" "0.884" "0.990" "1.000" "531.8" "550.3" "523.2" "582.4" "550.8" "518.4" "482.0" "470.3" "526.3" "531.7" "" "" "" "" "" "" "" "" "" "" "498.3" "455.4" "485.7" "450.2" "469.5" "495.2" "440.4" "417.6" "526.3" "512.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1038572201038202760" "False" "High" "IsMasterProtein" "P05114" "Non-histone chromosomal protein HMG-14 OS=Homo sapiens OX=9606 GN=HMGN1 PE=1 SV=3" "0.000" "False" "16.654" "40" "4" "11" "4" "100" "10.7" "9.60" "36.61" "4" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "3150" "ENSG00000205581" "HMGN1" "hsa:3150; P05114; Q3KQR8" "ATM signaling in development and disease ; p38 MAPK signaling pathway; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "8" "0" "0.979" "0.977" "0.991" "0.978" "0.974" "1.119" "0.964" "0.930" "0.965" "873.5" "855.1" "853.3" "866.1" "854.2" "851.0" "977.6" "842.1" "812.4" "842.9" "" "" "" "" "" "" "" "" "" "" "818.5" "707.6" "792.2" "669.5" "728.1" "813.1" "893.3" "747.7" "812.4" "811.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-519635040323081051" "False" "High" "IsMasterProtein" "P60953" "Cell division control protein 42 homolog OS=Homo sapiens OX=9606 GN=CDC42 PE=1 SV=2" "0.000" "False" "16.645" "17" "3" "6" "2" "191" "21.2" "6.55" "18.77" "3" "cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00071" "998" "ENSG00000070831" "CDC42" "hsa:998; P21181; P25763; P60953; Q7L8R5; Q9UDI2" "Androgen receptor signaling pathway; Target of rapamycin signaling; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Metastatic brain tumor; Pathogenic Escherichia coli infection; RalA downstream regulated genes; B cell receptor signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Focal adhesion; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Oxidative damage response; p38 MAPK signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; Genetic causes of porto-sinusoidal vascular disease; 13q12.12 copy number variation; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "RAC1 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; VEGFA-VEGFR2 Pathway; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; MAPK6/MAPK4 signaling; RHO GTPases Activate WASPs and WAVEs; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; EPHB-mediated forward signaling; DCC mediated attractive signaling; GPVI-mediated activation cascade; Myogenesis; Factors involved in megakaryocyte development and platelet production; G beta:gamma signalling through CDC42; EGFR downregulation; RHO GTPases activate PAKs; Inactivation of CDC42 and RAC1; CD28 dependent Vav1 pathway; RHO GTPases activate KTN1" "63" "0" "1.291" "1.060" "1.030" "1.095" "1.118" "0.904" "0.985" "1.170" "1.088" "871.8" "1125.2" "924.2" "897.7" "954.4" "975.1" "788.3" "858.4" "1019.8" "948.3" "" "" "" "" "" "" "" "" "" "" "816.9" "931.1" "858.0" "694.0" "813.5" "931.6" "720.3" "762.2" "1019.8" "913.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6706450895826488783" "False" "High" "IsMasterProtein" "Q9H9Q2" "COP9 signalosome complex subunit 7b OS=Homo sapiens OX=9606 GN=COPS7B PE=1 SV=1" "0.000" "False" "16.623" "22" "5" "5" "5" "264" "29.6" "6.15" "19.00" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf18392" "64708" "ENSG00000144524" "COPS7B" "hsa:64708; Q53S22; Q5BJG3; Q9H7V6; Q9H9Q2" "Ciliary landscape" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER" "5" "0" "0.942" "1.040" "0.984" "1.019" "1.000" "0.995" "0.998" "0.885" "0.976" "687.6" "647.4" "714.8" "676.7" "701.0" "687.5" "684.5" "686.5" "608.5" "670.9" "" "" "" "" "" "" "" "" "" "" "644.3" "535.7" "663.6" "523.1" "597.5" "656.9" "625.4" "609.6" "608.5" "646.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6670005547915153643" "False" "High" "IsMasterProtein" "O15400" "Syntaxin-7 OS=Homo sapiens OX=9606 GN=STX7 PE=1 SV=4" "0.000" "False" "16.615" "17" "4" "5" "4" "261" "29.8" "5.55" "20.17" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739, Pf14523" "8417" "ENSG00000079950" "STX7" "E1P579; hsa:8417; O15400; Q5SZW2; Q96ES9" "" "" "0" "0" "0.967" "0.900" "1.000" "1.050" "1.057" "1.226" "1.172" "1.107" "1.074" "291.8" "282.2" "262.5" "291.7" "306.4" "308.4" "357.9" "341.8" "323.1" "313.3" "" "" "" "" "" "" "" "" "" "" "273.4" "233.5" "243.7" "225.5" "261.2" "294.7" "327.0" "303.5" "323.1" "301.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8778470671322458913" "False" "High" "IsMasterProtein" "Q71UI9" "Histone H2A.V OS=Homo sapiens OX=9606 GN=H2AZ2 PE=1 SV=3" "0.000" "False" "16.607" "31" "4" "8" "2" "128" "13.5" "10.58" "23.47" "4" "cell organization and biogenesis" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "94239" "ENSG00000105968" "H2AZ2" "A6NFA8; A6NKY0; A6NN01; A8MQC5; hsa:94239; Q59GV8; Q6PK98; Q71UI9" "FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "Transcriptional regulation by small RNAs; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of the beta-catenin:TCF transactivating complex; RMTs methylate histone arginines; Meiotic synapsis; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Oxidative Stress Induced Senescence; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis" "35" "0" "1.013" "1.038" "1.133" "1.184" "1.133" "1.281" "1.307" "1.186" "1.156" "493.9" "500.1" "512.8" "559.5" "584.9" "559.4" "632.7" "645.6" "585.5" "570.9" "" "" "" "" "" "" "" "" "" "" "462.8" "413.8" "476.1" "432.5" "498.5" "534.4" "578.1" "573.2" "585.5" "549.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7018160903413407228" "False" "High" "IsMasterProtein" "Q9BW85" "Splicing factor YJU2 OS=Homo sapiens OX=9606 GN=YJU2 PE=1 SV=1" "0.000" "False" "16.602" "19" "5" "5" "4" "323" "37.1" "5.92" "18.51" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf04502" "55702" "ENSG00000105248" "YJU2" "hsa:55702; O75270; Q9BW85; Q9H862; Q9NW16" "" "mRNA Splicing - Major Pathway" "1" "1" "1.103" "0.999" "0.940" "1.072" "1.089" "0.960" "1.171" "1.074" "1.085" "853.1" "941.1" "851.9" "801.9" "914.2" "929.0" "819.0" "998.9" "916.1" "925.6" "" "" "" "" "" "" "" "" "" "" "799.4" "778.7" "790.9" "619.9" "779.3" "887.6" "748.4" "887.0" "916.1" "891.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5248794698895072137" "False" "High" "IsMasterProtein" "Q9NVC6" "Mediator of RNA polymerase II transcription subunit 17 OS=Homo sapiens OX=9606 GN=MED17 PE=1 SV=2" "0.000" "False" "16.588" "9" "6" "6" "6" "651" "72.8" "7.44" "17.69" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10156" "9440" "ENSG00000042429" "MED17" "B3KN07; hsa:9440; Q9HA81; Q9NVC6; Q9UNP7; Q9Y2W0; Q9Y660" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "1.060" "1.065" "1.043" "1.044" "1.075" "1.012" "1.005" "1.086" "1.096" "761.3" "807.3" "810.6" "793.7" "794.9" "818.2" "770.5" "764.9" "827.0" "834.4" "" "" "" "" "" "" "" "" "" "" "713.3" "668.0" "752.5" "613.5" "677.5" "781.7" "704.0" "679.2" "827.0" "803.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-200305812606160804" "False" "High" "IsMasterProtein" "Q3MHD2" "Protein LSM12 OS=Homo sapiens OX=9606 GN=LSM12 PE=1 SV=2" "0.000" "False" "16.565" "23" "4" "7" "4" "195" "21.7" "7.74" "20.83" "4" "" "other cell component" "nucleic acid binding activity" "Pf09793, Pf21166" "124801" "ENSG00000161654" "LSM12" "hsa:124801; Q3MHD2; Q86YB1; Q96NL5" "" "" "0" "0" "1.083" "1.094" "1.121" "1.118" "0.992" "1.063" "1.082" "1.099" "1.090" "385.3" "417.5" "421.6" "431.8" "430.8" "382.2" "409.7" "417.0" "423.5" "420.0" "" "" "" "" "" "" "" "" "" "" "361.1" "345.4" "391.4" "333.8" "367.2" "365.1" "374.4" "370.2" "423.5" "404.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8030741050122894286" "False" "High" "IsMasterProtein" "Q9NRH2" "SNF-related serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=SNRK PE=1 SV=2" "0.000" "False" "16.547" "7" "6" "6" "6" "765" "84.2" "7.06" "17.56" "6" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus" "kinase activity;other molecular function" "Pf00069" "54861" "ENSG00000163788" "SNRK" "B2RAV6; hsa:54861; Q14706; Q68D15; Q6IQ46; Q9NRH2; Q9NXI7" "" "" "0" "0" "0.976" "1.076" "1.067" "1.121" "1.096" "1.043" "1.050" "1.062" "1.058" "540.3" "527.2" "581.2" "576.5" "605.5" "592.2" "563.8" "567.5" "573.9" "571.5" "" "" "" "" "" "" "" "" "" "" "506.3" "436.2" "539.5" "445.7" "516.1" "565.8" "515.2" "503.9" "573.9" "550.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6132827760965537069" "False" "High" "IsMasterProtein" "Q7Z3D6" "D-glutamate cyclase, mitochondrial OS=Homo sapiens OX=9606 GN=DGLUCY PE=1 SV=2" "0.000" "False" "16.527" "9" "6" "7" "6" "616" "66.4" "6.79" "19.91" "6" "other metabolic processes" "mitochondrion" "other molecular function" "Pf07286, Pf14336" "80017" "ENSG00000133943" "DGLUCY" "B3KUI7; hsa:80017; Q7Z3D6; Q86SW3; Q86SX8; Q86SX9; Q86T08; Q86TV5; Q96GW5; Q9H7G0; Q9H8Y9; Q9H9W6" "" "" "0" "0" "1.028" "1.002" "0.963" "1.029" "1.015" "0.918" "0.996" "1.004" "1.062" "588.5" "605.2" "589.5" "567.0" "605.4" "597.1" "540.5" "586.4" "591.1" "624.9" "" "" "" "" "" "" "" "" "" "" "551.4" "500.8" "547.3" "438.3" "516.0" "570.5" "493.8" "520.7" "591.1" "601.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3251475669442544967" "False" "High" "IsMasterProtein" "Q9P270" "SLAIN motif-containing protein 2 OS=Homo sapiens OX=9606 GN=SLAIN2 PE=1 SV=2" "0.000" "False" "16.526" "9" "5" "7" "5" "581" "62.5" "9.45" "23.85" "5" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf15301" "57606" "ENSG00000109171" "SLAIN2" "A8K4P1; hsa:57606; Q8N5R3; Q9P270" "" "" "0" "0" "0.998" "0.957" "0.989" "1.018" "0.986" "1.025" "1.015" "1.017" "1.023" "564.8" "563.7" "540.5" "558.6" "575.3" "557.1" "578.8" "573.1" "574.4" "577.7" "" "" "" "" "" "" "" "" "" "" "529.3" "466.5" "501.8" "431.8" "490.3" "532.2" "528.9" "508.8" "574.4" "556.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3107820624180600590" "False" "High" "IsMasterProtein" "O75879" "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial OS=Homo sapiens OX=9606 GN=GATB PE=1 SV=1" "0.000" "False" "16.526" "10" "7" "8" "7" "557" "61.8" "8.63" "20.87" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf02637, Pf02934" "5188" "ENSG00000059691" "GATB" "hsa:5188; O75879; Q4W5M8; Q53GP4; Q9P0S6; Q9Y2B8" "" "" "0" "0" "1.060" "1.036" "1.029" "1.009" "1.097" "1.032" "0.957" "1.107" "1.057" "399.5" "423.3" "413.9" "411.0" "403.2" "438.2" "412.5" "382.2" "442.2" "422.4" "" "" "" "" "" "" "" "" "" "" "374.4" "350.3" "384.3" "317.7" "343.7" "418.6" "376.9" "339.4" "442.2" "406.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6115802108714275107" "False" "High" "IsMasterProtein" "P78330" "Phosphoserine phosphatase OS=Homo sapiens OX=9606 GN=PSPH PE=1 SV=2" "0.000" "False" "16.504" "28" "6" "8" "6" "225" "25.0" "5.69" "23.12" "6" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00702" "5723" "ENSG00000146733" "PSPH" "B2RCR5; hsa:5723; P78330; Q7Z3S5" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "Serine biosynthesis" "6" "0" "0.925" "0.980" "0.928" "0.963" "0.948" "0.912" "0.938" "0.934" "0.916" "1846.5" "1708.4" "1810.3" "1714.2" "1778.3" "1749.6" "1684.9" "1731.8" "1724.4" "1690.9" "" "" "" "" "" "" "" "" "" "" "1730.2" "1413.7" "1680.7" "1325.2" "1515.7" "1671.6" "1539.5" "1537.6" "1724.4" "1628.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5200719085873833637" "False" "High" "IsMasterProtein" "Q8NFW8" "N-acylneuraminate cytidylyltransferase OS=Homo sapiens OX=9606 GN=CMAS PE=1 SV=2" "0.000" "False" "16.490" "12" "5" "6" "5" "434" "48.3" "7.93" "19.33" "5" "other metabolic processes" "nucleus" "other molecular function" "Pf02348" "55907" "ENSG00000111726" "CMAS" "hsa:55907; Q8NFW8; Q96AX5; Q9NQZ0" "Sialylation" "Sialic acid metabolism" "2" "0" "1.022" "1.012" "1.071" "1.053" "1.051" "1.031" "1.056" "1.080" "1.092" "544.7" "556.8" "551.0" "583.6" "573.6" "572.3" "561.7" "574.9" "588.2" "594.9" "" "" "" "" "" "" "" "" "" "" "510.4" "460.8" "511.5" "451.1" "488.9" "546.7" "513.2" "510.5" "588.2" "572.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3731678403857668842" "False" "High" "IsMasterProtein" "P10768" "S-formylglutathione hydrolase OS=Homo sapiens OX=9606 GN=ESD PE=1 SV=2" "0.000" "False" "16.486" "18" "5" "15" "5" "282" "31.4" "7.02" "45.50" "5" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00756" "2098" "ENSG00000139684" "ESD" "hsa:2098; P10768; Q5TBU8; Q5TBV0; Q5TBV2; Q9BVJ2" "Phase I biotransformations, non-P450" "Glutathione conjugation" "2" "0" "0.976" "0.992" "0.968" "0.970" "0.977" "0.942" "0.958" "0.977" "0.954" "1394.5" "1361.3" "1383.2" "1350.3" "1352.5" "1362.3" "1313.3" "1335.5" "1361.9" "1330.1" "" "" "" "" "" "" "" "" "" "" "1306.6" "1126.4" "1284.1" "1043.9" "1152.9" "1301.6" "1200.0" "1185.8" "1361.9" "1280.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-255680334974208161" "False" "High" "IsMasterProtein" "Q9Y4K4" "Mitogen-activated protein kinase kinase kinase kinase 5 OS=Homo sapiens OX=9606 GN=MAP4K5 PE=1 SV=3" "0.000" "False" "16.483" "7" "6" "7" "6" "846" "95.0" "7.72" "21.51" "6" "other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf00069, Pf00780" "11183" "ENSG00000012983" "MAP4K5" "A0A804HIS2; hsa:11183" "Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Insulin signaling" "" "3" "0" "0.951" "1.004" "0.997" "0.997" "0.996" "0.956" "0.987" "0.967" "0.998" "1077.6" "1024.8" "1081.8" "1074.8" "1074.8" "1073.7" "1030.3" "1063.3" "1041.9" "1076.0" "" "" "" "" "" "" "" "" "" "" "1009.7" "848.0" "1004.3" "830.9" "916.1" "1025.8" "941.4" "944.1" "1041.9" "1036.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6481945204603063978" "False" "High" "IsMasterProtein" "Q9UBB6" "Neurochondrin OS=Homo sapiens OX=9606 GN=NCDN PE=1 SV=1" "0.000" "False" "16.479" "7" "5" "7" "5" "729" "78.8" "5.48" "21.90" "5" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf05536" "23154" "ENSG00000020129" "NCDN" "D3DPR9; hsa:23154; Q9UBB6; Q9UBY2; Q9Y4A6; Q9Y4D9" "Splicing factor NOVA regulated synaptic proteins" "" "1" "0" "0.981" "0.944" "1.008" "1.022" "0.960" "0.937" "0.887" "0.921" "0.969" "754.6" "740.3" "712.5" "760.8" "771.4" "724.6" "707.3" "669.6" "695.2" "730.9" "" "" "" "" "" "" "" "" "" "" "707.0" "612.6" "661.4" "588.2" "657.5" "692.2" "646.2" "594.6" "695.2" "703.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3676501743634657271" "False" "High" "IsMasterProtein" "P40855" "Peroxisomal biogenesis factor 19 OS=Homo sapiens OX=9606 GN=PEX19 PE=1 SV=1" "0.000" "False" "16.451" "19" "5" "5" "5" "299" "32.8" "4.34" "17.06" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04614" "5824" "ENSG00000162735" "PEX19" "D3DVE7; E9PPB4; G3V3G9; hsa:5824; P40855; Q5QNY4; Q8NI97" "TAR syndrome" "Class I peroxisomal membrane protein import; ABC transporters in lipid homeostasis" "3" "0" "1.093" "1.053" "1.063" "1.117" "1.151" "1.110" "1.235" "1.183" "1.172" "603.8" "660.1" "635.8" "641.9" "674.2" "694.8" "670.4" "745.9" "714.2" "707.8" "" "" "" "" "" "" "" "" "" "" "565.7" "546.2" "590.3" "496.2" "574.7" "663.8" "612.5" "662.3" "714.2" "681.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1630318732500359632" "False" "High" "IsMasterProtein" "P62280" "Small ribosomal subunit protein uS17 OS=Homo sapiens OX=9606 GN=RPS11 PE=1 SV=3" "0.000" "False" "16.442" "30" "6" "6" "6" "158" "18.4" "10.30" "19.71" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00366, Pf16205" "6205" "ENSG00000142534" "RPS11" "B2R4F5; hsa:6205; P04643; P62280; Q498Y6; Q6IRY0" "VEGFA-VEGFR2 signaling; IL-18 signaling pathway; Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "21" "0" "1.120" "1.075" "1.061" "1.068" "0.998" "1.231" "1.226" "1.129" "1.076" "1221.9" "1368.5" "1313.7" "1296.1" "1305.1" "1219.5" "1504.4" "1498.6" "1379.6" "1315.4" "" "" "" "" "" "" "" "" "" "" "1145.0" "1132.4" "1219.6" "1002.0" "1112.4" "1165.2" "1374.6" "1330.6" "1379.6" "1266.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7945924760519134314" "False" "High" "IsMasterProtein" "Q9H9C1" "Spermatogenesis-defective protein 39 homolog OS=Homo sapiens OX=9606 GN=VIPAS39 PE=1 SV=1" "0.000" "False" "16.437" "13" "6" "6" "6" "493" "57.0" "7.40" "14.78" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04840" "63894" "ENSG00000151445" "VIPAS39" "B4DPI6; hsa:63894; O95434; Q9H7E1; Q9H9C1; Q9H9I9" "" "" "0" "0" "0.946" "0.953" "1.047" "0.997" "1.006" "0.971" "0.985" "0.922" "0.936" "268.2" "253.7" "255.5" "280.8" "267.4" "269.7" "260.5" "264.2" "247.3" "251.1" "" "" "" "" "" "" "" "" "" "" "251.3" "209.9" "237.2" "217.0" "227.9" "257.7" "238.0" "234.6" "247.3" "241.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "76993751311903605" "False" "High" "IsMasterProtein" "Q9GZZ9" "Ubiquitin-like modifier-activating enzyme 5 OS=Homo sapiens OX=9606 GN=UBA5 PE=1 SV=1" "0.000" "False" "16.428" "16" "5" "6" "5" "404" "44.8" "4.84" "22.38" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00899" "79876" "ENSG00000081307" "UBA5" "A6NJL3; D3DNC8; hsa:79876; Q96ST1; Q9GZZ9" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.937" "1.018" "0.932" "0.971" "1.017" "0.897" "0.973" "0.959" "0.943" "784.0" "734.5" "798.3" "730.5" "761.6" "797.2" "703.3" "762.7" "751.7" "739.5" "" "" "" "" "" "" "" "" "" "" "734.6" "607.8" "741.2" "564.7" "649.2" "761.6" "642.7" "677.2" "751.7" "712.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7917759671781486439" "False" "High" "IsMasterProtein" "Q13627" "Dual specificity tyrosine-phosphorylation-regulated kinase 1A OS=Homo sapiens OX=9606 GN=DYRK1A PE=1 SV=2" "0.000" "False" "16.421" "7" "5" "5" "5" "763" "85.5" "8.75" "15.84" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "1859" "ENSG00000157540" "DYRK1A" "hsa:1859; O60769; Q13627; Q92582; Q92810; Q9UNM5" "T cell receptor and co-stimulatory signaling; DYRK1A involvement regarding cell proliferation in brain development" "G0 and Early G1" "3" "0" "0.912" "0.919" "1.116" "0.950" "0.946" "1.036" "0.966" "0.974" "0.969" "137.4" "125.3" "126.3" "153.4" "130.5" "130.0" "142.3" "132.8" "133.9" "133.2" "" "" "" "" "" "" "" "" "" "" "128.8" "103.7" "117.3" "118.6" "111.3" "124.2" "130.1" "117.9" "133.9" "128.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7606738261010209794" "False" "High" "IsMasterProtein" "Q7Z569" "BRCA1-associated protein OS=Homo sapiens OX=9606 GN=BRAP PE=1 SV=2" "0.000" "False" "16.415" "12" "6" "6" "6" "592" "67.3" "5.92" "17.48" "6" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02148, Pf07576, Pf13639" "8315" "ENSG00000089234" "BRAP" "B4DRM1; B9EGS8; hsa:8315; O43238; O75341; Q7Z569" "Ras signaling" "RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Negative regulation of MAPK pathway" "6" "0" "0.923" "0.967" "1.001" "0.969" "0.941" "0.924" "0.933" "0.954" "1.000" "1783.4" "1646.7" "1725.4" "1785.0" "1728.3" "1678.4" "1647.0" "1664.1" "1700.6" "1784.1" "" "" "" "" "" "" "" "" "" "" "1671.0" "1362.7" "1601.9" "1379.9" "1473.1" "1603.5" "1504.9" "1477.6" "1700.6" "1717.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8697682766688933342" "False" "High" "IsMasterProtein" "Q9GZZ1" "N-alpha-acetyltransferase 50 OS=Homo sapiens OX=9606 GN=NAA50 PE=1 SV=1" "0.000" "False" "16.414" "31" "5" "6" "5" "169" "19.4" "8.81" "21.11" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "80218" "ENSG00000121579" "NAA50" "D3DN74; hsa:80218; Q68DQ1; Q9GZZ1" "Metapathway biotransformation Phase I and II" "" "1" "0" "1.069" "1.095" "1.121" "1.121" "1.062" "0.952" "1.038" "1.053" "1.029" "360.2" "385.0" "394.5" "403.8" "403.7" "382.6" "342.8" "374.1" "379.4" "370.7" "" "" "" "" "" "" "" "" "" "" "337.5" "318.6" "366.3" "312.2" "344.1" "365.5" "313.2" "332.1" "379.4" "356.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5377093586219491132" "False" "High" "IsMasterProtein" "Q5VW36" "Focadhesin OS=Homo sapiens OX=9606 GN=FOCAD PE=1 SV=2" "0.000" "False" "16.412" "3" "6" "6" "6" "1801" "199.9" "6.62" "20.19" "6" "other biological processes" "cytosol;other cell component" "" "Pf11229, Pf12530" "54914" "ENSG00000188352" "FOCAD" "D3DRJ9; hsa:54914; Q5VW36; Q6ZME1; Q8IZG0; Q96JM8; Q96MS9; Q9BVF3; Q9NX87" "" "" "0" "0" "1.028" "1.019" "1.076" "1.032" "1.073" "1.103" "1.045" "1.051" "0.997" "578.6" "594.6" "589.7" "622.6" "597.2" "621.1" "638.3" "604.9" "608.1" "576.9" "" "" "" "" "" "" "" "" "" "" "542.1" "492.0" "547.4" "481.3" "509.0" "593.4" "583.2" "537.1" "608.1" "555.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9197774965471602114" "False" "High" "IsMasterProtein" "O60942" "mRNA-capping enzyme OS=Homo sapiens OX=9606 GN=RNGTT PE=1 SV=1" "0.000" "False" "16.383" "10" "6" "6" "6" "597" "68.5" "8.13" "17.86" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00782, Pf01331, Pf03919" "8732" "ENSG00000111880" "RNGTT" "E1P513; E1P514; hsa:8732; O43483; O60257; O60351; O60942; Q5TCW8; Q8WUM8" "mRNA processing; Ciliary landscape" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "5" "0" "0.937" "0.917" "1.022" "0.882" "0.898" "0.909" "0.932" "0.909" "0.934" "237.9" "222.8" "218.2" "243.0" "209.9" "213.7" "216.1" "221.8" "216.4" "222.3" "" "" "" "" "" "" "" "" "" "" "222.9" "184.4" "202.5" "187.9" "178.9" "204.2" "197.5" "196.9" "216.4" "214.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9072204051848657082" "False" "High" "IsMasterProtein" "O75832" "26S proteasome non-ATPase regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PSMD10 PE=1 SV=1" "0.000" "False" "16.381" "22" "5" "8" "5" "226" "24.4" "6.10" "17.75" "5" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf12796" "5716" "ENSG00000101843" "PSMD10" "hsa:5716; O75832; Q5U0B2; Q8IZK9" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway" "Degradation of DVL; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "61" "0" "0.958" "0.961" "0.946" "0.948" "0.986" "0.913" "0.983" "0.978" "0.944" "1146.1" "1098.3" "1101.6" "1084.2" "1086.0" "1130.2" "1046.5" "1126.3" "1120.3" "1081.7" "" "" "" "" "" "" "" "" "" "" "1073.9" "908.8" "1022.7" "838.1" "925.7" "1079.8" "956.2" "1000.0" "1120.3" "1041.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5140965250815444674" "False" "High" "IsMasterProtein" "Q9ULJ6" "Zinc finger MIZ domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZMIZ1 PE=1 SV=3" "0.000" "False" "16.379" "6" "7" "8" "4" "1067" "115.4" "7.46" "18.11" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02891, Pf18028" "57178" "ENSG00000108175" "ZMIZ1" "hsa:57178; Q5JSH9; Q7Z7E6; Q9ULJ6" "Androgen receptor signaling pathway" "" "1" "1" "0.999" "1.057" "0.987" "0.995" "1.036" "0.889" "0.900" "0.910" "0.982" "705.4" "704.5" "745.5" "696.1" "701.7" "730.5" "627.2" "635.0" "642.2" "693.0" "" "" "" "" "" "" "" "" "" "" "661.0" "583.0" "692.1" "538.1" "598.1" "697.9" "573.1" "563.8" "642.2" "667.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3338073365584811594" "False" "High" "IsMasterProtein" "P83731" "Large ribosomal subunit protein eL24 OS=Homo sapiens OX=9606 GN=RPL24 PE=1 SV=1" "0.000" "False" "16.366" "28" "5" "7" "5" "157" "17.8" "11.25" "22.49" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01246" "6152" "ENSG00000114391" "RPL24" "B2R4Y3; hsa:6152; P38663; P83731; Q6IBS3" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.046" "1.131" "1.128" "1.206" "1.226" "1.174" "1.105" "1.134" "1.097" "1004.9" "1051.0" "1136.8" "1133.7" "1211.6" "1231.9" "1179.8" "1110.8" "1140.0" "1102.5" "" "" "" "" "" "" "" "" "" "" "941.6" "869.7" "1055.4" "876.4" "1032.7" "1177.0" "1078.0" "986.3" "1140.0" "1061.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3934264021141742446" "False" "High" "IsMasterProtein" "Q9UI12" "V-type proton ATPase subunit H OS=Homo sapiens OX=9606 GN=ATP6V1H PE=1 SV=1" "0.000" "False" "16.351" "12" "5" "5" "5" "483" "55.8" "6.48" "16.40" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "transporter activity;enzyme regulator activity" "Pf03224, Pf11698" "51606" "ENSG00000047249" "ATP6V1H" "B3KMR0; hsa:51606; Q6PK44; Q9H3E3; Q9UI12; Q9Y300" "Proximal tubule transport" "Nef Mediated CD4 Down-regulation; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport; Nef Mediated CD8 Down-regulation; Blockage of phagosome acidification" "9" "0" "1.016" "1.060" "1.154" "1.042" "0.962" "1.054" "1.055" "0.962" "0.973" "145.1" "147.4" "153.8" "167.5" "151.2" "139.7" "152.9" "153.1" "139.7" "141.2" "" "" "" "" "" "" "" "" "" "" "136.0" "122.0" "142.8" "129.5" "128.8" "133.4" "139.8" "136.0" "139.7" "136.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "968979890096343817" "False" "High" "IsMasterProtein" "P53611" "Geranylgeranyl transferase type-2 subunit beta OS=Homo sapiens OX=9606 GN=RABGGTB PE=1 SV=2" "0.000" "False" "16.350" "11" "4" "6" "4" "331" "36.9" "5.03" "20.44" "4" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00432" "5876" "ENSG00000137955" "RABGGTB" "hsa:5876; P53611; Q92697" "" "RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "2" "0" "0.944" "0.993" "0.969" "0.930" "0.951" "0.979" "0.959" "0.928" "0.971" "514.8" "485.9" "510.9" "498.6" "478.9" "489.6" "504.1" "493.7" "477.8" "499.7" "" "" "" "" "" "" "" "" "" "" "482.3" "402.1" "474.3" "385.5" "408.2" "467.8" "460.6" "438.3" "477.8" "481.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5723353511819689268" "False" "High" "IsMasterProtein" "Q92947" "Glutaryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=GCDH PE=1 SV=1" "0.000" "False" "16.349" "15" "6" "9" "6" "438" "48.1" "8.06" "21.06" "6" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "2639" "ENSG00000105607" "GCDH" "A8K2Z2; O14719; Q92947" "Fatty acid beta-oxidation; Tryptophan metabolism" "Lysine catabolism" "3" "0" "1.019" "1.002" "0.943" "0.987" "0.975" "0.951" "0.963" "0.970" "0.928" "1596.3" "1626.5" "1599.6" "1505.3" "1575.6" "1556.9" "1518.1" "1537.4" "1549.2" "1482.1" "" "" "" "" "" "" "" "" "" "" "1495.7" "1345.9" "1485.0" "1163.6" "1343.0" "1487.5" "1387.1" "1365.0" "1549.2" "1427.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2097918301010195378" "False" "High" "IsMasterProtein" "P28715" "DNA excision repair protein ERCC-5 OS=Homo sapiens OX=9606 GN=ERCC5 PE=1 SV=3" "0.000" "False" "16.345" "6" "6" "6" "6" "1186" "133.0" "5.22" "17.39" "6" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00752, Pf00867" "2073" "ENSG00000134899" "ERCC5" "A6NGT4; hsa:2073; P28715; Q5JUS4; Q5JUS5; Q7Z2V3; Q8IZL6; Q8N1B7; Q9HD59; Q9HD60" "Nucleotide excision repair; DNA repair pathways, full network; p53 transcriptional gene network; 10q11.21q11.23 copy number variation syndrome" "Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "7" "0" "1.005" "0.895" "0.965" "0.957" "0.983" "0.931" "0.889" "0.883" "0.937" "425.5" "427.7" "380.9" "410.5" "407.1" "418.3" "396.2" "378.1" "375.6" "398.7" "" "" "" "" "" "" "" "" "" "" "398.7" "354.0" "353.6" "317.4" "347.0" "399.7" "362.0" "335.7" "375.6" "383.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8004592446864816783" "False" "High" "IsMasterProtein" "O75688" "Protein phosphatase 1B OS=Homo sapiens OX=9606 GN=PPM1B PE=1 SV=1" "0.000" "False" "16.338" "13" "5" "5" "4" "479" "52.6" "5.05" "18.42" "5" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf00481, Pf07830" "5495" "ENSG00000138032" "PPM1B" "hsa:5495; O75688; Q461Q2; Q4J6C1; Q4J6C2; Q658R4; Q96ER6; Q9HAY8" "MAPK signaling pathway" "ISG15 antiviral mechanism; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "4" "0" "0.955" "1.025" "0.920" "0.918" "1.038" "0.976" "0.929" "0.976" "0.996" "548.3" "523.4" "562.1" "504.4" "503.4" "568.9" "535.2" "509.4" "534.9" "546.3" "" "" "" "" "" "" "" "" "" "" "513.7" "433.1" "521.8" "389.9" "429.1" "543.5" "489.1" "452.3" "534.9" "526.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8633785530779633839" "False" "High" "IsMasterProtein" "P49354" "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha OS=Homo sapiens OX=9606 GN=FNTA PE=1 SV=1" "0.000" "False" "16.326" "18" "6" "7" "6" "379" "44.4" "5.08" "19.71" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf01239" "2339" "ENSG00000168522" "FNTA" "A6NJW0; hsa:2339; P49354; Q53XJ9; Q9UDC1" "Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "Potential therapeutics for SARS; Inactivation, recovery and regulation of the phototransduction cascade; RAS processing; Apoptotic cleavage of cellular proteins" "9" "0" "1.024" "1.095" "1.001" "1.012" "1.150" "1.017" "1.016" "1.174" "1.084" "173.0" "177.1" "189.5" "173.3" "175.0" "199.1" "176.0" "175.9" "203.1" "187.6" "" "" "" "" "" "" "" "" "" "" "162.1" "146.6" "175.9" "134.0" "149.2" "190.2" "160.8" "156.1" "203.1" "180.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9042131036706186365" "False" "High" "IsMasterProtein" "Q13485" "Mothers against decapentaplegic homolog 4 OS=Homo sapiens OX=9606 GN=SMAD4 PE=1 SV=1" "0.000" "False" "16.323" "10" "6" "6" "6" "552" "60.4" "6.99" "19.27" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4089" "ENSG00000141646" "SMAD4" "A8K405; hsa:4089; Q13485" "Androgen receptor signaling pathway; Bone morphogenic protein signaling and regulation; Heart development; Cell cycle; Endoderm differentiation; Mesodermal commitment pathway; Ectoderm differentiation; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Hepatitis C and hepatocellular carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Vitamin D in inflammatory diseases; Envelope proteins and their potential roles in EDMD physiopathology; Hepatitis B infection; Head and neck squamous cell carcinoma; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Angiotensin II receptor type 1 pathway; Neuroinflammation and glutamatergic signaling; Progeria-associated lipodystrophy; Clock-controlled autophagy in bone metabolism; Rubinstein-Taybi syndrome 1; TGF-beta receptor signaling; DNA damage response (only ATM dependent)" "Ub-specific processing proteases; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Signaling by BMP; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Cardiogenesis; Germ layer formation at gastrulation; Formation of definitive endoderm; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Transcriptional regulation of pluripotent stem cells; RUNX3 regulates BCL2L11 (BIM) transcription; RUNX2 regulates bone development; Signaling by Activin; TGF-beta receptor signaling activates SMADs; RUNX3 regulates CDKN1A transcription; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer" "53" "0" "0.957" "0.967" "0.961" "0.956" "0.928" "0.923" "0.944" "0.939" "0.964" "1669.3" "1598.1" "1614.1" "1603.7" "1596.5" "1548.8" "1541.2" "1575.5" "1568.0" "1609.0" "" "" "" "" "" "" "" "" "" "" "1564.1" "1322.4" "1498.5" "1239.7" "1360.9" "1479.7" "1408.2" "1398.9" "1568.0" "1549.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "173468840260374204" "False" "High" "IsMasterProtein" "Q86WB0" "Zinc finger C3HC-type protein 1 OS=Homo sapiens OX=9606 GN=ZC3HC1 PE=1 SV=1" "0.000" "False" "16.305" "13" "6" "6" "6" "502" "55.2" "5.62" "20.99" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;nucleus" "other molecular function" "Pf07967, Pf08600" "51530" "ENSG00000091732" "ZC3HC1" "A6NH66; hsa:51530; Q75MF3; Q75MF4; Q86WB0; Q8N330; Q96F75; Q9HA34; Q9NVX4; Q9P0R0" "" "Nuclear events stimulated by ALK signaling in cancer" "1" "0" "0.949" "1.034" "1.029" "1.021" "1.016" "1.032" "1.009" "1.021" "1.033" "1341.6" "1272.9" "1387.5" "1380.1" "1369.8" "1362.5" "1384.8" "1354.2" "1370.1" "1386.3" "" "" "" "" "" "" "" "" "" "" "1257.1" "1053.3" "1288.1" "1066.9" "1167.6" "1301.7" "1265.3" "1202.4" "1370.1" "1334.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4988344905656775202" "False" "High" "IsMasterProtein" "Q92665" "Small ribosomal subunit protein mS31 OS=Homo sapiens OX=9606 GN=MRPS31 PE=1 SV=3" "0.000" "False" "16.302" "15" "6" "6" "6" "395" "45.3" "9.29" "22.92" "6" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf15433" "10240" "ENSG00000102738" "MRPS31" "B2RCS3; hsa:10240; Q5VYC8; Q8WTV8; Q92665" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.026" "1.080" "1.023" "1.069" "1.096" "1.019" "0.978" "1.063" "1.098" "870.1" "893.2" "939.8" "889.7" "930.1" "953.5" "886.8" "850.9" "925.3" "955.2" "" "" "" "" "" "" "" "" "" "" "815.3" "739.1" "872.5" "687.8" "792.8" "910.9" "810.3" "755.5" "925.3" "919.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2007854671863603578" "False" "High" "IsMasterProtein" "P46734" "Dual specificity mitogen-activated protein kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP2K3 PE=1 SV=2" "0.000" "False" "16.291" "14" "5" "5" "3" "347" "39.3" "7.43" "18.55" "5" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5606" "ENSG00000034152" "MAP2K3" "B3KSK7; hsa:5606; P46734; Q99441; Q9UE71; Q9UE72" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Endoderm differentiation; Photodynamic therapy-induced AP-1 survival signaling; TGF-beta signaling pathway; MAPK signaling pathway; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; 16p11.2 proximal deletion syndrome; Pleural mesothelioma; GNAQ pathways in port-wine stain; Interferon type I signaling pathways; Serotonin HTR1 group and FOS pathway; Toll-like receptor signaling pathway" "Oxidative Stress Induced Senescence; activated TAK1 mediates p38 MAPK activation" "34" "2" "1.036" "1.009" "0.997" "0.994" "1.000" "0.937" "0.956" "0.986" "0.978" "1324.8" "1372.7" "1336.5" "1320.7" "1317.2" "1325.4" "1241.1" "1266.9" "1305.8" "1295.2" "" "" "" "" "" "" "" "" "" "" "1241.3" "1135.9" "1240.8" "1020.9" "1122.8" "1266.3" "1134.1" "1124.9" "1305.8" "1247.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5089087001200962096" "False" "High" "IsMasterProtein" "Q12802" "A-kinase anchor protein 13 OS=Homo sapiens OX=9606 GN=AKAP13 PE=1 SV=2" "0.000" "False" "16.288" "3" "6" "6" "6" "2813" "307.4" "5.24" "17.72" "6" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621, Pf10522" "11214" "ENSG00000170776" "AKAP13" "hsa:11214; Q12802; Q14572; Q59FP6; Q86W90; Q8WXQ6; Q96JP6; Q96P79; Q9Y5T0; Q9Y5T6" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; G protein signaling pathways" "RHOC GTPase cycle; RHOA GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle" "8" "0" "1.025" "0.953" "1.061" "1.028" "0.972" "1.011" "0.927" "0.956" "0.986" "1084.4" "1111.8" "1033.8" "1150.8" "1114.4" "1054.4" "1095.9" "1005.2" "1037.2" "1068.8" "" "" "" "" "" "" "" "" "" "" "1016.1" "920.0" "959.7" "889.6" "949.9" "1007.4" "1001.3" "892.5" "1037.2" "1029.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "841037560780449706" "False" "High" "IsMasterProtein" "O43663" "Protein regulator of cytokinesis 1 OS=Homo sapiens OX=9606 GN=PRC1 PE=1 SV=2" "0.000" "False" "16.278" "10" "7" "9" "6" "620" "71.6" "6.68" "25.02" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03999" "9055" "ENSG00000198901" "PRC1" "A6NC44; B4DLR1; H9KV59; hsa:9055; O43663; Q9BSB6" "" "RHO GTPases activate CIT" "1" "0" "0.932" "1.001" "0.985" "0.983" "1.017" "0.907" "0.947" "0.933" "0.967" "985.8" "919.3" "987.0" "970.7" "969.3" "1002.2" "893.6" "933.7" "919.6" "953.0" "" "" "" "" "" "" "" "" "" "" "923.7" "760.7" "916.3" "750.4" "826.2" "957.5" "816.6" "829.0" "919.6" "917.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2297110738803864325" "False" "High" "IsMasterProtein" "P30044" "Peroxiredoxin-5, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX5 PE=1 SV=4" "0.000" "False" "16.273" "22" "4" "9" "4" "214" "22.1" "8.70" "26.64" "4" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf08534" "25824" "ENSG00000126432" "PRDX5" "A6NC19; A6NG06; B7ZLJ4; B7ZVW3; hsa:25824; P30044; Q14CK0; Q6IAF2; Q9UBU5; Q9UJU4; Q9UKX4" "Selenium micronutrient network" "" "1" "0" "1.030" "1.026" "1.130" "1.067" "1.048" "1.065" "0.990" "1.007" "1.085" "504.2" "519.1" "517.3" "570.0" "538.0" "528.4" "536.8" "498.9" "507.6" "546.9" "" "" "" "" "" "" "" "" "" "" "472.4" "429.6" "480.2" "440.6" "458.5" "504.8" "490.5" "443.0" "507.6" "526.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5527327330749920032" "False" "High" "IsMasterProtein" "P61019" "Ras-related protein Rab-2A OS=Homo sapiens OX=9606 GN=RAB2A PE=1 SV=1" "0.000" "False" "16.267" "23" "5" "6" "5" "212" "23.5" "6.54" "19.72" "5" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "5862" "ENSG00000104388" "RAB2A" "B2R5W8; B4DMQ5; hsa:5862; P08886; P61019" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape" "RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization" "4" "0" "0.964" "0.958" "0.990" "1.057" "1.024" "0.924" "1.043" "1.045" "0.998" "571.6" "551.1" "547.6" "566.1" "604.2" "585.4" "527.9" "596.4" "597.5" "570.5" "" "" "" "" "" "" "" "" "" "" "535.6" "456.0" "508.4" "437.6" "515.0" "559.3" "482.4" "529.6" "597.5" "549.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5588774124192242024" "False" "High" "IsMasterProtein" "P54132" "RecQ-like DNA helicase BLM OS=Homo sapiens OX=9606 GN=BLM PE=1 SV=1" "0.000" "False" "16.265" "4" "7" "9" "6" "1417" "158.9" "7.49" "17.77" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00570, Pf08072, Pf09382, Pf16124, Pf16202, Pf16204" "641" "ENSG00000197299" "BLM" "hsa:641; P54132; Q52M96" "Primary ovarian insufficiency" "Resolution of D-loop Structures through Holliday Junction Intermediates; SUMOylation of DNA damage response and repair proteins; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Processive synthesis on the C-strand of the telomere" "18" "0" "0.996" "0.977" "1.149" "1.044" "1.072" "1.309" "1.126" "1.218" "1.113" "193.5" "192.7" "189.1" "222.3" "202.0" "207.4" "253.2" "217.8" "235.6" "215.3" "" "" "" "" "" "" "" "" "" "" "181.3" "159.5" "175.6" "171.9" "172.2" "198.2" "231.4" "193.4" "235.6" "207.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4174205388023222362" "False" "High" "IsMasterProtein" "Q96H20" "Vacuolar-sorting protein SNF8 OS=Homo sapiens OX=9606 GN=SNF8 PE=1 SV=1" "0.000" "False" "16.250" "20" "5" "5" "5" "258" "28.8" "6.65" "18.32" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04157" "11267" "ENSG00000159210" "SNF8" "hsa:11267; Q8IXY3; Q96H20; Q9UN50" "" "Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events" "2" "0" "0.888" "0.960" "0.922" "0.942" "0.942" "0.903" "0.911" "0.892" "0.897" "773.6" "687.3" "742.9" "713.3" "728.8" "728.5" "698.6" "704.7" "690.2" "694.2" "" "" "" "" "" "" "" "" "" "" "724.9" "568.7" "689.7" "551.4" "621.2" "696.1" "638.3" "625.7" "690.2" "668.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8999845406277562527" "False" "High" "IsMasterProtein" "Q9H089" "Large subunit GTPase 1 homolog OS=Homo sapiens OX=9606 GN=LSG1 PE=1 SV=2" "0.000" "False" "16.227" "8" "6" "6" "6" "658" "75.2" "6.38" "18.71" "6" "transport" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf01926" "55341" "ENSG00000041802" "LSG1" "A0JLT4; A0PJK3; A6NI18; hsa:55341; Q7L9H8; Q9H089; Q9NUK8" "" "" "0" "0" "1.094" "1.096" "1.160" "1.212" "1.194" "1.325" "1.247" "1.329" "1.214" "432.4" "472.9" "474.1" "501.4" "524.0" "516.5" "572.8" "539.2" "574.5" "525.1" "" "" "" "" "" "" "" "" "" "" "405.2" "391.3" "440.1" "387.6" "446.7" "493.5" "523.4" "478.8" "574.5" "505.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1131809670189224217" "False" "High" "IsMasterProtein" "Q96EY7" "Small ribosomal subunit protein mS39 OS=Homo sapiens OX=9606 GN=PTCD3 PE=1 SV=3" "0.000" "False" "16.222" "10" "6" "7" "6" "689" "78.5" "6.42" "21.89" "6" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;translational apparatus;nucleus" "translation activity;nucleic acid binding activity" "Pf13041, Pf13812" "55037" "ENSG00000132300" "PTCD3" "A6NHD2; D6W5M1; hsa:55037; Q597H0; Q658Y9; Q96EY7; Q9BUZ8; Q9NWL0" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.037" "1.036" "0.976" "1.002" "1.020" "0.950" "0.964" "0.951" "1.016" "954.9" "990.2" "989.3" "931.9" "957.0" "973.9" "907.0" "920.6" "908.6" "970.5" "" "" "" "" "" "" "" "" "" "" "894.8" "819.4" "918.5" "720.4" "815.7" "930.5" "828.7" "817.4" "908.6" "934.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4122244859069195901" "False" "High" "IsMasterProtein" "Q9NVM6" "DnaJ homolog subfamily C member 17 OS=Homo sapiens OX=9606 GN=DNAJC17 PE=1 SV=1" "0.000" "False" "16.197" "19" "6" "6" "6" "304" "34.7" "8.53" "19.20" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00226" "55192" "ENSG00000104129" "DNAJC17" "hsa:55192; Q9NVM6" "" "" "0" "0" "1.039" "1.056" "1.039" "1.243" "1.137" "1.101" "1.154" "1.355" "1.088" "660.3" "686.1" "696.9" "685.9" "820.7" "750.5" "726.9" "761.9" "894.9" "718.5" "" "" "" "" "" "" "" "" "" "" "618.7" "567.8" "647.0" "530.2" "699.6" "717.0" "664.2" "676.5" "894.9" "691.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8194850060938304098" "False" "High" "IsMasterProtein" "Q8N5I9" "NOP protein chaperone 1 OS=Homo sapiens OX=9606 GN=NOPCHAP1 PE=1 SV=2" "0.000" "False" "16.194" "29" "6" "7" "6" "185" "20.1" "5.22" "21.70" "6" "cell organization and biogenesis" "nucleus" "other molecular function" "Pf15370" "121053" "ENSG00000151131" "NOPCHAP1" "Q8N5I9" "" "" "0" "0" "1.010" "0.956" "0.947" "0.979" "1.031" "0.919" "0.938" "0.910" "1.017" "838.4" "846.8" "801.3" "794.1" "821.1" "864.6" "770.8" "786.1" "762.9" "852.4" "" "" "" "" "" "" "" "" "" "" "785.6" "700.7" "743.9" "613.9" "699.9" "826.0" "704.3" "698.0" "762.9" "820.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7819708601940239359" "False" "High" "IsMasterProtein" "P51946" "Cyclin-H OS=Homo sapiens OX=9606 GN=CCNH PE=1 SV=1" "0.000" "False" "16.187" "16" "5" "6" "5" "323" "37.6" "7.15" "19.21" "5" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "enzyme regulator activity" "Pf00134, Pf16899" "902" "ENSG00000134480" "CCNH" "hsa:902; P51946; Q53X72; Q8TBL9" "Cell cycle; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "39" "0" "0.924" "0.922" "1.029" "0.962" "0.944" "1.008" "1.010" "1.008" "0.970" "553.3" "511.4" "510.2" "569.2" "532.0" "522.3" "557.5" "559.0" "557.7" "536.9" "" "" "" "" "" "" "" "" "" "" "518.5" "423.2" "473.7" "440.0" "453.5" "499.0" "509.4" "496.4" "557.7" "517.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5532813342924820659" "False" "High" "IsMasterProtein" "Q9Y383" "Putative RNA-binding protein Luc7-like 2 OS=Homo sapiens OX=9606 GN=LUC7L2 PE=1 SV=2" "0.000" "False" "16.187" "14" "6" "7" "4" "392" "46.5" "10.01" "21.93" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03194" "51631" "ENSG00000146963" "LUC7L2" "B7Z500; hsa:51631; Q8IUP9; Q9NVL3; Q9NVN7; Q9UQN1; Q9Y383" "" "" "0" "2" "1.099" "1.169" "1.019" "0.988" "1.035" "1.014" "0.977" "1.030" "1.028" "1362.7" "1497.0" "1592.7" "1388.5" "1346.4" "1410.4" "1382.1" "1331.1" "1404.1" "1401.4" "" "" "" "" "" "" "" "" "" "" "1276.8" "1238.7" "1478.6" "1073.4" "1147.6" "1347.5" "1262.9" "1181.9" "1404.1" "1349.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8312057505130700222" "False" "High" "IsMasterProtein" "P06865" "Beta-hexosaminidase subunit alpha OS=Homo sapiens OX=9606 GN=HEXA PE=1 SV=2" "0.000" "False" "16.160" "14" "8" "10" "7" "529" "60.7" "5.16" "23.95" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00728, Pf14845" "3073" "ENSG00000213614" "HEXA" "B4DKE7; E7ENH7; hsa:3073; P06865; Q53HS8; Q6AI32" "Degradation pathway of sphingolipids, including diseases; Glycosaminoglycan degradation" "CS/DS degradation; Hyaluronan uptake and degradation; Glycosphingolipid catabolism; Keratan sulfate degradation; Defective HEXA causes GM2G1" "7" "0" "0.903" "0.988" "0.919" "1.013" "1.051" "0.942" "0.975" "0.972" "0.988" "564.9" "509.9" "558.0" "519.4" "572.5" "593.5" "531.9" "550.7" "549.0" "558.1" "" "" "" "" "" "" "" "" "" "" "529.3" "421.9" "518.0" "401.6" "488.0" "567.1" "486.0" "489.0" "549.0" "537.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "364086976847350379" "False" "High" "IsMasterProtein" "Q7L592" "Protein arginine methyltransferase NDUFAF7, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAF7 PE=1 SV=1" "0.000" "False" "16.158" "16" "6" "8" "6" "441" "49.2" "8.34" "25.69" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf02636" "55471" "ENSG00000003509" "NDUFAF7" "hsa:55471; Q7L592; Q7Z399; Q9P1G3" "" "Complex I biogenesis" "1" "0" "1.064" "0.981" "1.107" "1.165" "1.031" "1.040" "1.049" "1.025" "1.186" "251.1" "267.2" "246.2" "277.9" "292.4" "258.7" "261.2" "263.3" "257.3" "297.9" "" "" "" "" "" "" "" "" "" "" "235.2" "221.1" "228.5" "214.8" "249.2" "247.2" "238.6" "233.8" "257.3" "286.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3312961601966625911" "False" "High" "IsMasterProtein" "Q96EY8" "Corrinoid adenosyltransferase MMAB OS=Homo sapiens OX=9606 GN=MMAB PE=1 SV=1" "0.000" "False" "16.156" "22" "5" "7" "5" "250" "27.4" "8.60" "25.30" "5" "other metabolic processes" "mitochondrion" "other molecular function" "Pf01923" "326625" "ENSG00000139428" "MMAB" "C5HU05; hsa:326625; Q96EY8; Q9BSH0" "Vitamin B12 metabolism" "Cobalamin (Cbl) metabolism; Defective MMAB causes MMA, cblB type" "3" "0" "1.026" "0.975" "0.964" "1.034" "1.080" "0.983" "0.981" "1.031" "1.029" "922.0" "945.8" "899.1" "889.1" "953.1" "995.5" "906.3" "904.6" "950.4" "948.4" "" "" "" "" "" "" "" "" "" "" "863.9" "782.6" "834.7" "687.3" "812.4" "951.1" "828.1" "803.2" "950.4" "913.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4388316332710741736" "False" "High" "IsMasterProtein" "Q96FS4" "Signal-induced proliferation-associated protein 1 OS=Homo sapiens OX=9606 GN=SIPA1 PE=1 SV=1" "0.000" "False" "16.156" "4" "4" "7" "4" "1042" "112.1" "6.60" "17.62" "4" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf00595, Pf02145, Pf21022" "6494" "ENSG00000213445" "SIPA1" "hsa:6494; O14518; O60484; O60618; Q2YD83; Q96FS4" "MAPK cascade" "Rap1 signalling" "2" "0" "1.105" "1.064" "1.204" "1.180" "1.128" "1.288" "1.143" "1.157" "1.125" "409.4" "452.6" "435.6" "493.1" "483.2" "462.0" "527.1" "467.7" "473.9" "460.6" "" "" "" "" "" "" "" "" "" "" "383.6" "374.5" "404.4" "381.2" "411.8" "441.4" "481.6" "415.3" "473.9" "443.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1343964700997120443" "False" "High" "IsMasterProtein" "O94830" "Phospholipase DDHD2 OS=Homo sapiens OX=9606 GN=DDHD2 PE=1 SV=2" "0.000" "False" "16.142" "7" "5" "6" "5" "711" "81.0" "5.39" "19.55" "5" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00536, Pf02825, Pf02862" "23259" "ENSG00000085788" "DDHD2" "B3KWV2; B3KXB5; hsa:23259; O94830; Q9H8X7" "" "Synthesis of PA" "1" "0" "0.948" "0.960" "0.964" "1.009" "1.016" "0.949" "0.952" "0.954" "1.002" "1026.1" "972.9" "985.4" "988.9" "1035.5" "1042.4" "973.7" "976.6" "978.9" "1028.6" "" "" "" "" "" "" "" "" "" "" "961.4" "805.1" "914.8" "764.5" "882.7" "995.9" "889.7" "867.1" "978.9" "990.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "123318016964233677" "False" "High" "IsMasterProtein" "O75489" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS3 PE=1 SV=1" "0.000" "False" "16.123" "22" "5" "7" "5" "264" "30.2" "7.50" "19.30" "5" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion;nucleus" "transporter activity;other molecular function" "Pf00329" "4722" "ENSG00000213619" "NDUFS3" "B2R9J1; B4DFM8; hsa:4722; O75489; Q9UNQ8" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "RHOG GTPase cycle; Complex I biogenesis; Mitochondrial protein degradation" "7" "0" "0.989" "1.119" "1.107" "1.092" "1.111" "1.003" "0.915" "0.957" "1.081" "175.6" "173.7" "196.4" "194.3" "191.7" "195.0" "176.1" "160.6" "168.1" "189.7" "" "" "" "" "" "" "" "" "" "" "164.5" "143.7" "182.3" "150.2" "163.4" "186.3" "160.9" "142.6" "168.1" "182.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7011076575076357199" "False" "High" "IsMasterProtein" "O00442" "RNA 3'-terminal phosphate cyclase OS=Homo sapiens OX=9606 GN=RTCA PE=1 SV=1" "0.000" "False" "16.118" "14" "5" "5" "5" "366" "39.3" "7.85" "16.44" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01137, Pf05189" "8634" "ENSG00000137996" "RTCA" "hsa:8634; O00442; Q5VVL5; Q5VVL6; Q96E99" "" "" "0" "0" "0.895" "0.913" "0.954" "0.950" "1.055" "0.976" "0.916" "1.009" "1.024" "540.6" "483.6" "493.5" "515.5" "513.4" "570.0" "527.7" "495.1" "545.7" "553.6" "" "" "" "" "" "" "" "" "" "" "506.5" "400.2" "458.1" "398.5" "437.6" "544.6" "482.2" "439.6" "545.7" "533.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5727120310183573784" "False" "High" "IsMasterProtein" "Q92560" "Ubiquitin carboxyl-terminal hydrolase BAP1 OS=Homo sapiens OX=9606 GN=BAP1 PE=1 SV=2" "0.000" "False" "16.113" "8" "5" "5" "5" "729" "80.3" "6.84" "13.13" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01088, Pf18031" "8314" "ENSG00000163930" "BAP1" "A8K993; hsa:8314; Q6LEM0; Q7Z5E8; Q92560" "Clear cell renal cell carcinoma pathways; Pleural mesothelioma; Kleefstra syndrome" "UCH proteinases; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" "5" "0" "1.024" "1.142" "1.174" "1.194" "1.214" "1.126" "1.151" "1.018" "1.154" "375.5" "384.6" "428.8" "440.8" "448.4" "455.9" "422.8" "432.3" "382.1" "433.4" "" "" "" "" "" "" "" "" "" "" "351.8" "318.3" "398.1" "340.7" "382.2" "435.6" "386.3" "383.8" "382.1" "417.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5622868530505354295" "False" "High" "IsMasterProtein" "O60315" "Zinc finger E-box-binding homeobox 2 OS=Homo sapiens OX=9606 GN=ZEB2 PE=1 SV=1" "0.000" "False" "16.112" "5" "5" "5" "5" "1214" "136.4" "6.32" "15.16" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00096, Pf05605, Pf12874" "9839" "ENSG00000169554" "ZEB2" "A0JP09; B7Z2P2; F5H814; hsa:9839; O60315; Q9UED1" "Mammary gland development pathway - Embryonic development (Stage 1 of 4); TGF-beta signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; TGF-beta receptor signaling in skeletal dysplasias; CCL18 signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; Macrophage-stimulating protein (MSP) signaling network map; TGF-beta receptor signaling" "Formation of the anterior neural plate; Formation of the posterior neural plate; Regulation of CDH11 gene transcription" "11" "0" "0.953" "0.973" "0.957" "0.941" "0.947" "0.959" "0.885" "0.931" "0.998" "380.5" "362.5" "370.1" "364.2" "358.1" "360.4" "365.1" "336.8" "354.4" "379.7" "" "" "" "" "" "" "" "" "" "" "356.5" "299.9" "343.6" "281.6" "305.2" "344.3" "333.6" "299.0" "354.4" "365.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7687733002656654502" "False" "High" "IsMasterProtein" "P18031" "Tyrosine-protein phosphatase non-receptor type 1 OS=Homo sapiens OX=9606 GN=PTPN1 PE=1 SV=1" "0.000" "False" "16.112" "11" "5" "6" "5" "435" "49.9" "6.27" "19.46" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00102" "5770" "ENSG00000196396" "PTPN1" "hsa:5770; P18031; Q5TGD8; Q9BQV9; Q9NQQ4" "Leptin signaling pathway; Prolactin signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling" "Growth hormone receptor signaling; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Negative regulation of MET activity; Insulin receptor recycling; Integrin signaling; MECP2 regulates neuronal receptors and channels; PTK6 Down-Regulation" "14" "0" "1.027" "0.918" "1.060" "1.004" "0.980" "0.994" "0.999" "1.020" "1.013" "239.4" "245.9" "219.8" "253.7" "240.3" "234.6" "237.9" "239.1" "244.2" "242.5" "" "" "" "" "" "" "" "" "" "" "224.3" "203.5" "204.0" "196.1" "204.8" "224.1" "217.4" "212.3" "244.2" "233.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8218333417811039911" "False" "High" "IsMasterProtein" "Q9H299" "SH3 domain-binding glutamic acid-rich-like protein 3 OS=Homo sapiens OX=9606 GN=SH3BGRL3 PE=1 SV=1" "0.000" "False" "16.094" "47" "5" "14" "5" "93" "10.4" "4.93" "42.03" "5" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf04908" "83442" "ENSG00000142669" "SH3BGRL3" "hsa:83442; Q5T122; Q9H299" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.010" "0.974" "0.930" "0.975" "0.933" "0.980" "0.977" "0.951" "0.950" "1170.5" "1182.7" "1139.7" "1089.0" "1141.7" "1091.6" "1147.0" "1143.6" "1113.2" "1112.0" "" "" "" "" "" "" "" "" "" "" "1096.8" "978.7" "1058.1" "841.9" "973.2" "1042.9" "1048.0" "1015.4" "1113.2" "1070.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "103112105648951971" "False" "High" "IsMasterProtein" "Q8NB16" "Mixed lineage kinase domain-like protein OS=Homo sapiens OX=9606 GN=MLKL PE=1 SV=1" "0.000" "False" "16.086" "12" "6" "6" "6" "471" "54.4" "8.82" "16.08" "6" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf07714" "197259" "ENSG00000168404" "MLKL" "A6NCE4; hsa:197259; Q8N6V0; Q8NB16" "DNA damage response (only ATM dependent)" "Regulation of necroptotic cell death; TRP channels; Microbial modulation of RIPK1-mediated regulated necrosis" "5" "0" "1.079" "0.979" "0.974" "1.015" "1.043" "0.990" "1.052" "1.054" "1.017" "909.5" "981.3" "890.5" "885.4" "922.7" "948.5" "900.6" "956.7" "958.2" "924.7" "" "" "" "" "" "" "" "" "" "" "852.2" "812.0" "826.7" "684.5" "786.5" "906.2" "822.9" "849.5" "958.2" "890.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8561031833154832659" "False" "High" "IsMasterProtein" "O15379" "Histone deacetylase 3 OS=Homo sapiens OX=9606 GN=HDAC3 PE=1 SV=2" "0.000" "False" "16.084" "11" "6" "6" "5" "428" "48.8" "5.16" "19.31" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850" "8841" "ENSG00000171720" "HDAC3" "D3DQE1; hsa:8841; O15379; O43268; Q9UEI5; Q9UEV0" "Neural crest differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Transcription co-factors SKI and SKIL protein partners; 22q11.2 copy number variation syndrome; IL-18 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Regulation of PTEN gene transcription; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Cytoprotection by HMOX1; Association of TriC/CCT with target proteins during biosynthesis; NR1D1 (REV-ERBA) represses gene expression; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; STAT3 nuclear events downstream of ALK signaling" "31" "0" "0.964" "0.975" "0.889" "0.979" "0.977" "0.905" "0.942" "0.962" "0.953" "1008.1" "972.1" "982.5" "896.7" "986.5" "984.8" "912.8" "950.1" "969.4" "961.2" "" "" "" "" "" "" "" "" "" "" "944.6" "804.4" "912.1" "693.2" "840.9" "940.9" "834.0" "843.6" "969.4" "925.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5032092853006601019" "False" "High" "IsMasterProtein" "Q13303" "Voltage-gated potassium channel subunit beta-2 OS=Homo sapiens OX=9606 GN=KCNAB2 PE=1 SV=2" "0.000" "False" "16.067" "15" "6" "8" "6" "367" "41.0" "9.00" "23.74" "6" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "transporter activity;other molecular function" "Pf00248" "8514" "ENSG00000069424" "KCNAB2" "A0AVM9; A8K1A4; B0AZR7; hsa:8514; O43659; Q13303; Q2YD85; Q5TG82; Q5TG83; Q6ZNE4; Q99411" "Metapathway biotransformation Phase I and II" "Neutrophil degranulation; Voltage gated Potassium channels" "3" "0" "0.959" "0.981" "1.026" "0.926" "1.057" "0.968" "1.006" "0.962" "1.040" "439.0" "420.8" "430.6" "450.3" "406.5" "464.1" "424.8" "441.6" "422.4" "456.4" "" "" "" "" "" "" "" "" "" "" "411.3" "348.2" "399.7" "348.1" "346.4" "443.4" "388.1" "392.1" "422.4" "439.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3128972635678329678" "False" "High" "IsMasterProtein" "Q9BUT1" "Dehydrogenase/reductase SDR family member 6 OS=Homo sapiens OX=9606 GN=BDH2 PE=1 SV=2" "0.000" "False" "16.059" "21" "5" "8" "5" "245" "26.7" "7.65" "28.15" "5" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13561" "56898" "ENSG00000164039" "BDH2" "A8K295; B4DUF6; hsa:56898; Q503A0; Q6IA46; Q6UWD3; Q9BUT1; Q9H8S8; Q9NRX8" "" "Synthesis of Ketone Bodies" "1" "0" "0.906" "0.956" "0.987" "0.956" "0.960" "0.915" "0.924" "0.896" "0.936" "1554.9" "1409.3" "1486.3" "1533.9" "1487.3" "1493.1" "1422.0" "1437.0" "1392.6" "1454.9" "" "" "" "" "" "" "" "" "" "" "1456.9" "1166.2" "1379.8" "1185.8" "1267.7" "1426.5" "1299.4" "1275.9" "1392.6" "1400.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7181464862980127615" "False" "High" "IsMasterProtein" "Q13630" "GDP-L-fucose synthase OS=Homo sapiens OX=9606 GN=GFUS PE=1 SV=1" "0.000" "False" "16.056" "15" "4" "6" "4" "321" "35.9" "6.60" "19.95" "4" "cell adhesion;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01370" "7264" "ENSG00000104522; ENSG00000278243" "GFUS" "B2R8Y7; D3DWK5; hsa:7264; Q13630; Q567Q9; Q9UDG7" "" "GDP-fucose biosynthesis" "1" "0" "1.007" "0.979" "1.001" "0.938" "0.980" "0.934" "0.935" "0.932" "0.933" "637.1" "641.6" "623.7" "637.7" "597.5" "624.4" "595.0" "596.0" "593.6" "594.6" "" "" "" "" "" "" "" "" "" "" "597.0" "530.9" "579.0" "492.9" "509.3" "596.5" "543.7" "529.2" "593.6" "572.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-100353375695918439" "False" "High" "IsMasterProtein" "P53999" "Activated RNA polymerase II transcriptional coactivator p15 OS=Homo sapiens OX=9606 GN=SUB1 PE=1 SV=3" "0.000" "False" "16.041" "26" "3" "11" "3" "127" "14.4" "9.60" "28.91" "3" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02229" "10923" "ENSG00000113387" "SUB1" "hsa:10923; P53999; Q96L29" "" "" "0" "0" "1.042" "0.976" "0.998" "0.976" "0.918" "0.952" "0.943" "1.041" "0.946" "1817.3" "1893.5" "1773.3" "1813.4" "1774.3" "1668.8" "1729.6" "1714.3" "1890.9" "1718.5" "" "" "" "" "" "" "" "" "" "" "1702.8" "1566.9" "1646.3" "1401.8" "1512.4" "1594.4" "1580.4" "1522.2" "1890.9" "1654.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "798152879982526566" "False" "High" "IsMasterProtein" "Q8WWH5" "Pseudouridylate synthase TRUB1 OS=Homo sapiens OX=9606 GN=TRUB1 PE=1 SV=1" "0.000" "False" "16.022" "15" "5" "7" "5" "349" "37.2" "8.25" "18.19" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf01509" "142940" "ENSG00000165832" "TRUB1" "B2R716; hsa:142940; Q53ES2; Q8WWH5" "" "" "0" "0" "1.074" "1.016" "0.977" "1.026" "1.038" "0.957" "0.897" "0.968" "1.038" "343.9" "369.4" "349.3" "336.0" "352.8" "356.9" "329.1" "308.5" "333.0" "356.9" "" "" "" "" "" "" "" "" "" "" "322.3" "305.7" "324.2" "259.7" "300.7" "341.0" "300.7" "273.9" "333.0" "343.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1125859041744935918" "False" "High" "IsMasterProtein" "Q96HA7" "Tonsoku-like protein OS=Homo sapiens OX=9606 GN=TONSL PE=1 SV=2" "0.000" "False" "16.017" "4" "6" "7" "6" "1378" "150.8" "6.42" "19.26" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00023, Pf13181, Pf13516" "4796" "ENSG00000160949" "TONSL" "B5MDP0; C9JKB1; C9JNV8; hsa:4796; Q13006; Q96HA7; Q9UGJ2" "" "" "0" "0" "0.997" "0.990" "1.035" "1.035" "1.078" "1.018" "1.059" "1.071" "1.048" "422.0" "420.8" "417.8" "436.6" "436.8" "454.7" "429.7" "447.0" "452.0" "442.3" "" "" "" "" "" "" "" "" "" "" "395.4" "348.2" "387.9" "337.5" "372.3" "434.5" "392.7" "396.9" "452.0" "425.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6937145884149963662" "False" "High" "IsMasterProtein" "Q15306" "Interferon regulatory factor 4 OS=Homo sapiens OX=9606 GN=IRF4 PE=1 SV=1" "0.000" "False" "16.010" "14" "6" "8" "6" "451" "51.7" "6.86" "21.38" "6" "cell organization and biogenesis;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3662" "ENSG00000137265" "IRF4" "hsa:3662; Q15306; Q5VUI7; Q99660" "B cell receptor signaling pathway; Apoptosis; Vitamin D receptor pathway; Pre-implantation embryo; Development of pulmonary dendritic cells and macrophage subsets; Prion disease pathway; White fat cell differentiation; Th17 cell differentiation pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; Type II interferon signaling; T-cell receptor signaling pathway" "Nuclear events stimulated by ALK signaling in cancer; Interferon alpha/beta signaling; Interleukin-4 and Interleukin-13 signaling; Interferon gamma signaling" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5741463921085592561" "False" "High" "IsMasterProtein" "O75962" "Triple functional domain protein OS=Homo sapiens OX=9606 GN=TRIO PE=1 SV=2" "0.000" "False" "16.003" "2" "7" "7" "7" "3097" "346.7" "6.37" "14.26" "7" "cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00018, Pf00069, Pf00169, Pf00435, Pf00621, Pf07679, Pf13716, Pf16609" "7204" "ENSG00000038382" "TRIO" "D3DTD1; hsa:7204; O75962; Q13458; Q59EQ7; Q6PJC9; Q6ZN05; Q8IWK8" "Microtubule cytoskeleton regulation; Neural crest cell migration during development; Neural crest cell migration in cancer; GNAQ pathways in port-wine stain" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; DCC mediated attractive signaling" "15" "0" "0.979" "0.976" "1.091" "1.041" "0.950" "0.971" "0.874" "0.892" "0.905" "418.6" "409.7" "408.6" "456.7" "435.6" "397.8" "406.3" "365.9" "373.2" "379.0" "" "" "" "" "" "" "" "" "" "" "392.2" "339.0" "379.3" "353.1" "371.3" "380.1" "371.3" "324.9" "373.2" "364.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5640697701811177027" "False" "High" "IsMasterProtein" "Q8TAG9" "Exocyst complex component 6 OS=Homo sapiens OX=9606 GN=EXOC6 PE=1 SV=3" "0.000" "False" "15.968" "6" "6" "8" "6" "804" "93.7" "6.20" "21.28" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf04091, Pf20651" "54536" "ENSG00000138190" "EXOC6" "E9PHI3; hsa:54536; Q5VXH8; Q8TAG9; Q9NZ24" "Interactions between LOXL4 and oxidative stress pathway; Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "5" "0" "0.993" "0.997" "1.017" "1.020" "1.010" "1.005" "0.933" "0.970" "1.001" "716.0" "710.7" "714.1" "727.9" "730.4" "723.2" "719.8" "668.1" "694.3" "716.7" "" "" "" "" "" "" "" "" "" "" "670.9" "588.1" "662.9" "562.7" "622.6" "690.9" "657.7" "593.2" "694.3" "690.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1948996399981661341" "False" "High" "IsMasterProtein" "Q2TAL8" "Transcriptional regulator QRICH1 OS=Homo sapiens OX=9606 GN=QRICH1 PE=1 SV=1" "0.000" "False" "15.964" "6" "4" "5" "4" "776" "86.4" "5.87" "16.09" "4" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf12012" "54870" "ENSG00000198218" "QRICH1" "hsa:54870; Q2TAL8; Q4G0F7; Q7L621; Q8TEA5" "" "" "0" "0" "0.981" "0.992" "0.918" "0.953" "0.990" "0.892" "0.895" "0.917" "0.991" "921.1" "903.3" "913.7" "845.7" "877.9" "911.9" "821.7" "824.5" "844.2" "912.8" "" "" "" "" "" "" "" "" "" "" "863.1" "747.5" "848.2" "653.8" "748.3" "871.2" "750.8" "732.1" "844.2" "878.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3291285492636401918" "False" "High" "IsMasterProtein" "Q9H974" "Queuine tRNA-ribosyltransferase accessory subunit 2 OS=Homo sapiens OX=9606 GN=QTRT2 PE=1 SV=1" "0.000" "False" "15.958" "17" "4" "5" "4" "415" "46.7" "6.81" "22.02" "4" "RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01702" "79691" "ENSG00000151576" "QTRT2" "A6NGE9; B7Z472; B7Z5R2; hsa:79691; J3KR78; Q6IA59; Q9H974" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.083" "1.115" "1.220" "1.136" "1.060" "1.121" "1.036" "1.061" "1.046" "219.0" "237.1" "244.1" "267.1" "248.7" "232.2" "245.5" "227.0" "232.4" "229.0" "" "" "" "" "" "" "" "" "" "" "205.2" "196.2" "226.6" "206.5" "212.0" "221.8" "224.3" "201.5" "232.4" "220.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9132635867397603913" "False" "High" "IsMasterProtein" "Q53T59" "HCLS1-binding protein 3 OS=Homo sapiens OX=9606 GN=HS1BP3 PE=1 SV=1" "0.000" "False" "15.948" "19" "5" "6" "5" "392" "42.8" "5.01" "19.61" "5" "other biological processes" "mitochondrion;ER/Golgi" "other molecular function" "Pf00787" "64342" "ENSG00000118960" "HS1BP3" "B2RAW2; D6W529; hsa:64342; Q53T59; Q86VC2; Q8N367" "" "" "0" "0" "1.339" "0.966" "1.304" "1.139" "1.218" "1.111" "1.062" "1.007" "1.054" "34.7" "46.5" "33.6" "45.3" "39.6" "42.3" "38.6" "36.9" "35.0" "36.6" "" "" "" "" "" "" "" "" "" "" "32.6" "38.5" "31.2" "35.0" "33.7" "40.4" "35.3" "32.8" "35.0" "35.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7310593134022698633" "False" "High" "IsMasterProtein" "P57081" "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 OS=Homo sapiens OX=9606 GN=WDR4 PE=1 SV=2" "0.000" "False" "15.940" "12" "4" "6" "4" "412" "45.5" "7.11" "21.48" "4" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf00400" "10785" "ENSG00000160193" "WDR4" "A8KA58; B2RCA3; B4DNQ7; D3DSK3; hsa:10785; P57081; Q9BVM5; Q9HCR3" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.970" "0.976" "0.908" "0.949" "0.930" "0.933" "0.976" "0.955" "0.931" "1359.8" "1319.2" "1326.9" "1234.3" "1290.7" "1264.5" "1268.7" "1327.1" "1299.2" "1266.4" "" "" "" "" "" "" "" "" "" "" "1274.1" "1091.7" "1231.9" "954.2" "1100.2" "1208.1" "1159.2" "1178.4" "1299.2" "1219.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3045251361027418727" "False" "High" "IsMasterProtein" "O43237" "Cytoplasmic dynein 1 light intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1LI2 PE=1 SV=1" "0.000" "False" "15.940" "13" "5" "5" "5" "492" "54.1" "6.38" "17.97" "5" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05783" "1783" "ENSG00000135720" "DYNC1LI2" "A8K6V1; B4DZP4; hsa:1783; O43237; Q8TAT3" "Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption" "HCMV Early Events; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "14" "0" "0.985" "0.990" "1.073" "0.996" "0.969" "1.000" "0.985" "1.009" "1.037" "567.7" "559.2" "562.1" "609.2" "565.6" "550.4" "567.7" "559.3" "573.0" "588.9" "" "" "" "" "" "" "" "" "" "" "532.0" "462.7" "521.9" "470.9" "482.1" "525.8" "518.8" "496.6" "573.0" "567.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9115702628811982031" "False" "High" "IsMasterProtein" "Q8N5A5" "Zinc finger CCCH-type with G patch domain-containing protein OS=Homo sapiens OX=9606 GN=ZGPAT PE=1 SV=3" "0.000" "False" "15.935" "9" "5" "6" "5" "531" "57.3" "5.43" "18.35" "5" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01585, Pf18044" "84619" "ENSG00000197114" "ZGPAT" "E1P5K1; hsa:84619; Q4VXN9; Q5JWI9; Q5JWJ0; Q8N5A5; Q8NC55; Q8WUV4; Q96JI0; Q96JU4; Q9H401" "" "" "0" "0" "1.288" "1.059" "1.138" "1.123" "1.123" "0.912" "0.753" "0.913" "1.037" "82.1" "105.8" "87.0" "93.5" "92.3" "92.2" "74.9" "61.9" "75.0" "85.1" "" "" "" "" "" "" "" "" "" "" "77.0" "87.5" "80.8" "72.3" "78.7" "88.1" "68.5" "54.9" "75.0" "82.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5585340363182511889" "False" "High" "IsMasterProtein" "Q9HBU6" "Ethanolamine kinase 1 OS=Homo sapiens OX=9606 GN=ETNK1 PE=1 SV=1" "0.000" "False" "15.933" "12" "6" "10" "5" "452" "50.9" "6.54" "31.04" "6" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01633" "55500" "ENSG00000139163" "ETNK1" "G5E969; hsa:55500; Q9HBU6" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids" "Synthesis of PE" "5" "0" "0.918" "0.993" "0.886" "0.901" "0.931" "0.838" "0.876" "0.902" "0.950" "1478.4" "1357.4" "1468.3" "1309.8" "1332.2" "1377.0" "1239.0" "1294.6" "1333.4" "1403.9" "" "" "" "" "" "" "" "" "" "" "1385.3" "1123.3" "1363.1" "1012.5" "1135.5" "1315.6" "1132.1" "1149.4" "1333.4" "1351.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1787588940823929001" "False" "High" "IsMasterProtein" "P61224" "Ras-related protein Rap-1b OS=Homo sapiens OX=9606 GN=RAP1B PE=1 SV=1" "0.000" "False" "15.912" "27" "5" "7" "5" "184" "20.8" "5.78" "16.81" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5908" "ENSG00000127314" "RAP1B" "B2R5Z2; B4DQI8; B4DW74; B4DW94; hsa:5908; P09526; P61224; Q502X3; Q5TZR4; Q6DCA1; Q6LES0" "Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Androgen receptor network in prostate cancer; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling" "Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Rap1 signalling; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1" "26" "0" "0.955" "0.912" "0.906" "0.988" "0.916" "0.989" "0.951" "0.949" "0.954" "130.5" "124.7" "119.1" "118.3" "129.0" "119.6" "129.1" "124.1" "123.9" "124.5" "" "" "" "" "" "" "" "" "" "" "122.3" "103.2" "110.5" "91.4" "109.9" "114.3" "118.0" "110.2" "123.9" "119.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7640891103846222335" "False" "High" "IsMasterProtein" "O94819" "Kelch repeat and BTB domain-containing protein 11 OS=Homo sapiens OX=9606 GN=KBTBD11 PE=1 SV=1" "0.000" "False" "15.904" "10" "6" "7" "6" "623" "65.7" "6.07" "21.18" "6" "" "" "" "Pf00651, Pf01344" "9920" "ENSG00000176595; ENSG00000273645" "KBTBD11" "hsa:9920; O94819; Q3L1I0" "" "" "0" "0" "0.965" "1.020" "0.963" "1.005" "0.964" "0.958" "0.986" "1.010" "1.009" "633.3" "611.1" "645.8" "609.6" "636.7" "610.6" "606.8" "624.1" "639.6" "639.1" "" "" "" "" "" "" "" "" "" "" "593.4" "505.7" "599.5" "471.2" "542.7" "583.4" "554.4" "554.2" "639.6" "615.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5921429182500705176" "False" "High" "IsMasterProtein" "O43765" "Small glutamine-rich tetratricopeptide repeat-containing protein alpha OS=Homo sapiens OX=9606 GN=SGTA PE=1 SV=1" "0.000" "False" "15.903" "19" "5" "7" "5" "313" "34.0" "4.87" "21.76" "5" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00515, Pf13181, Pf16546" "6449" "ENSG00000104969" "SGTA" "D6W610; hsa:6449; O43765; Q6FIA9; Q9BTZ9" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "1.176" "1.059" "1.051" "1.062" "1.107" "1.083" "1.036" "1.004" "1.147" "733.7" "863.0" "776.8" "771.2" "779.5" "812.1" "794.6" "759.8" "736.4" "841.8" "" "" "" "" "" "" "" "" "" "" "687.5" "714.1" "721.2" "596.2" "664.4" "775.9" "726.1" "674.6" "736.4" "810.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2031700092780878303" "False" "High" "IsMasterProtein" "Q9Y5L4" "Mitochondrial import inner membrane translocase subunit Tim13 OS=Homo sapiens OX=9606 GN=TIMM13 PE=1 SV=1" "0.000" "False" "15.894" "37" "3" "6" "3" "95" "10.5" "8.18" "20.96" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf02953" "26517" "ENSG00000099800" "TIMM13" "hsa:26517; P62206; Q9UHL8; Q9WTL1; Q9Y5L4" "" "Mitochondrial protein import" "1" "0" "1.095" "1.083" "1.099" "1.114" "1.104" "1.094" "1.114" "0.961" "1.109" "256.2" "280.4" "277.4" "281.5" "285.5" "282.8" "280.2" "285.5" "246.2" "284.1" "" "" "" "" "" "" "" "" "" "" "240.0" "232.0" "257.6" "217.6" "243.3" "270.2" "256.0" "253.5" "246.2" "273.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7172726289989085897" "False" "High" "IsMasterProtein" "Q8IYB5" "Stromal membrane-associated protein 1 OS=Homo sapiens OX=9606 GN=SMAP1 PE=1 SV=2" "0.000" "False" "15.866" "9" "4" "8" "3" "467" "50.4" "8.75" "25.27" "4" "other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "60682" "ENSG00000112305" "SMAP1" "hsa:60682; Q53H70; Q5SYQ2; Q6PK24; Q8IYB5; Q8NDH4; Q96L38; Q96L39; Q9H8X4" "" "" "0" "0" "0.952" "0.963" "0.969" "0.947" "0.964" "0.900" "0.915" "0.971" "0.857" "520.5" "495.5" "501.2" "504.5" "492.8" "501.6" "468.3" "476.5" "505.2" "445.9" "" "" "" "" "" "" "" "" "" "" "487.7" "410.0" "465.3" "390.0" "420.1" "479.3" "427.9" "423.1" "505.2" "429.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3396014057802155010" "False" "High" "IsMasterProtein" "Q15910" "Histone-lysine N-methyltransferase EZH2 OS=Homo sapiens OX=9606 GN=EZH2 PE=1 SV=2" "0.000" "False" "15.846" "7" "5" "5" "5" "746" "85.3" "7.02" "17.43" "5" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00856, Pf11616, Pf18118, Pf18264, Pf21358" "2146" "ENSG00000106462" "EZH2" "B2RAQ1; B3KS30; B7Z1D6; B7Z7L6; hsa:2146; Q15755; Q15910; Q75MG3; Q92857; Q96FI6" "Cell differentiation - expanded index; Histone modifications; Endoderm differentiation; Interactome of polycomb repressive complex 2 (PRC2) ; MECP2 and associated Rett syndrome; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma" "Oxidative Stress Induced Senescence; HCMV Early Events; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis" "19" "0" "1.024" "1.082" "0.963" "1.143" "1.032" "1.044" "1.045" "1.111" "1.068" "865.8" "886.3" "936.9" "833.9" "989.6" "893.1" "903.9" "904.4" "961.6" "924.8" "" "" "" "" "" "" "" "" "" "" "811.3" "733.4" "869.8" "644.6" "843.5" "853.3" "825.9" "803.1" "961.6" "890.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7123841880797263349" "False" "High" "IsMasterProtein" "P09382" "Galectin-1 OS=Homo sapiens OX=9606 GN=LGALS1 PE=1 SV=2" "0.000" "False" "15.842" "37" "5" "7" "5" "135" "14.7" "5.50" "21.30" "5" "cell adhesion;other biological processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00337" "3956" "ENSG00000100097" "LGALS1" "B2R5E8; hsa:3956; P09382; Q9UDK5" "Immune infiltration in pancreatic cancer" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "3" "0" "1.053" "0.975" "1.011" "1.003" "1.046" "1.057" "1.075" "1.040" "1.033" "1935.5" "2038.7" "1887.0" "1957.3" "1941.8" "2023.8" "2045.9" "2080.0" "2012.3" "1998.8" "" "" "" "" "" "" "" "" "" "" "1813.6" "1687.0" "1751.8" "1513.0" "1655.1" "1933.5" "1869.4" "1846.9" "2012.3" "1924.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2241526083572897290" "False" "High" "IsMasterProtein" "Q9ULX6" "A-kinase anchor protein 8-like OS=Homo sapiens OX=9606 GN=AKAP8L PE=1 SV=4" "0.000" "False" "15.841" "10" "5" "9" "5" "646" "71.6" "5.05" "28.18" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04988" "26993" "ENSG00000011243" "AKAP8L" "B4DJ74; B5BU90; hsa:26993; O94792; Q96J58; Q9NRQ0; Q9UGM0; Q9ULX6" "" "Formation of WDR5-containing histone-modifying complexes" "1" "0" "0.977" "1.029" "1.054" "0.955" "1.020" "0.984" "0.978" "0.934" "1.001" "720.7" "703.8" "741.4" "759.5" "688.2" "735.2" "709.3" "704.9" "673.2" "721.5" "" "" "" "" "" "" "" "" "" "" "675.3" "582.4" "688.3" "587.1" "586.6" "702.4" "648.1" "625.9" "673.2" "694.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5277181117143708744" "False" "High" "IsMasterProtein" "P60866" "Small ribosomal subunit protein uS10 OS=Homo sapiens OX=9606 GN=RPS20 PE=1 SV=1" "0.000" "False" "15.837" "35" "5" "7" "5" "119" "13.4" "9.94" "22.59" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00338" "6224" "ENSG00000008988" "RPS20" "B2R4F4; B4DW28; hsa:6224; P17075; P60866; Q5M8S9" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.202" "1.169" "1.199" "1.197" "1.121" "1.367" "1.290" "1.284" "1.232" "570.9" "686.1" "667.2" "684.5" "683.5" "640.0" "780.6" "736.4" "732.8" "703.1" "" "" "" "" "" "" "" "" "" "" "534.9" "567.7" "619.4" "529.2" "582.6" "611.5" "713.3" "653.8" "732.8" "677.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4865533649162524419" "False" "High" "IsMasterProtein" "P28702" "Retinoic acid receptor RXR-beta OS=Homo sapiens OX=9606 GN=RXRB PE=1 SV=2" "0.000" "False" "15.822" "9" "6" "6" "6" "533" "56.9" "8.18" "15.92" "6" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105" "6257" "ENSG00000204231; ENSG00000206289; ENSG00000227322; ENSG00000228333; ENSG00000231321; ENSG00000235712" "RXRB" "hsa:6257; P28702; P28703; Q59G65; Q5JP92; Q5STQ1" "Vitamin D metabolism; Nuclear receptors; PPAR signaling pathway; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Small cell lung cancer; IL-18 signaling pathway; Vitamin A1 and A5/X pathways; Vitamin A and carotenoid metabolism" "PPARA activates gene expression; Signaling by Retinoic Acid; Nuclear Receptor transcription pathway; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis; NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake ; NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis" "18" "0" "0.996" "1.028" "0.985" "1.043" "0.988" "0.922" "0.974" "0.932" "0.961" "369.5" "368.1" "379.8" "364.1" "385.3" "365.1" "340.5" "359.9" "344.5" "355.1" "" "" "" "" "" "" "" "" "" "" "346.2" "304.6" "352.6" "281.5" "328.4" "348.9" "311.2" "319.5" "344.5" "341.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8285089334394207834" "False" "High" "IsMasterProtein" "Q12959" "Disks large homolog 1 OS=Homo sapiens OX=9606 GN=DLG1 PE=1 SV=2" "0.000" "False" "15.822" "6" "6" "7" "6" "904" "100.4" "5.76" "19.01" "6" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00018, Pf00595, Pf00625, Pf09058, Pf10600, Pf10608" "1739" "ENSG00000075711" "DLG1" "A5YKK7; B4DGU1; B4DGZ8; B7ZMM0; B9EIQ5; D3DXB8; D3DXB9; E7EWL7; E9PG21; hsa:1739; Q12958; Q12959" "Brain-derived neurotrophic factor (BDNF) signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Disruption of postsynaptic signaling by CNV; 3q29 copy number variation syndrome; Cell lineage map for neuronal differentiation" "RAF/MAP kinase cascade; Assembly and cell surface presentation of NMDA receptors; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; NrCAM interactions; Activation of Ca-permeable Kainate Receptor" "15" "0" "0.958" "1.015" "1.013" "0.979" "1.019" "0.988" "1.032" "1.069" "1.109" "280.5" "268.6" "284.6" "284.0" "274.5" "285.9" "277.0" "289.3" "299.8" "311.2" "" "" "" "" "" "" "" "" "" "" "262.8" "222.3" "264.3" "219.5" "234.0" "273.1" "253.1" "256.9" "299.8" "299.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2508229497243424265" "False" "High" "IsMasterProtein" "P82673" "Small ribosomal subunit protein mS35 OS=Homo sapiens OX=9606 GN=MRPS35 PE=1 SV=1" "0.000" "False" "15.820" "23" "6" "9" "6" "323" "36.8" "8.24" "25.44" "6" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10213" "60488" "ENSG00000061794" "MRPS35" "hsa:60488; P82673; Q32LZ1; Q6P4C6; Q7L1M6; Q8NBP4; Q96AI0; Q9H044; Q9HC14; Q9P1R5" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.982" "0.956" "1.088" "1.051" "1.065" "0.953" "0.986" "0.916" "1.022" "230.4" "226.1" "220.1" "250.6" "242.1" "245.3" "219.4" "227.0" "210.9" "235.4" "" "" "" "" "" "" "" "" "" "" "215.9" "187.1" "204.4" "193.7" "206.3" "234.4" "200.5" "201.6" "210.9" "226.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3096317975956610268" "False" "High" "IsMasterProtein" "Q9HBL8" "NmrA-like family domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NMRAL1 PE=1 SV=1" "0.000" "False" "15.793" "19" "7" "7" "7" "299" "33.3" "7.52" "18.01" "7" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf05368" "57407" "ENSG00000153406; ENSG00000274684" "NMRAL1" "hsa:57407; Q9HBL8" "" "Urea cycle" "1" "0" "0.977" "0.987" "0.988" "0.966" "0.953" "0.914" "0.949" "0.940" "0.994" "1093.6" "1067.9" "1079.7" "1080.6" "1056.7" "1041.8" "999.6" "1038.1" "1027.8" "1086.5" "" "" "" "" "" "" "" "" "" "" "1024.7" "883.7" "1002.3" "835.3" "900.7" "995.4" "913.3" "921.8" "1027.8" "1046.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8657288411045177937" "False" "High" "IsMasterProtein" "O95429" "BAG family molecular chaperone regulator 4 OS=Homo sapiens OX=9606 GN=BAG4 PE=1 SV=1" "0.000" "False" "15.792" "12" "5" "10" "4" "457" "49.6" "5.12" "37.02" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf02179" "9530" "ENSG00000156735" "BAG4" "B4E217; hsa:9530; O95429; O95818" "Oxidative damage response" "Signaling by FGFR1 in disease; Regulation of HSF1-mediated heat shock response; Signaling by plasma membrane FGFR1 fusions; TNF signaling" "5" "0" "1.106" "1.039" "1.099" "1.072" "1.110" "1.097" "1.078" "1.057" "1.065" "753.2" "833.0" "782.4" "827.8" "807.8" "836.4" "826.6" "812.2" "796.5" "802.0" "" "" "" "" "" "" "" "" "" "" "705.8" "689.3" "726.4" "639.9" "688.6" "799.1" "755.3" "721.1" "796.5" "772.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2000966759959030184" "False" "High" "IsMasterProtein" "Q9H267" "Vacuolar protein sorting-associated protein 33B OS=Homo sapiens OX=9606 GN=VPS33B PE=1 SV=2" "0.000" "False" "15.771" "9" "6" "7" "6" "617" "70.5" "6.71" "21.36" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00995" "26276" "ENSG00000184056" "VPS33B" "B3KQF6; hsa:26276; Q96K14; Q9H267; Q9NRP6; Q9NSF3" "" "Prevention of phagosomal-lysosomal fusion; SARS-CoV-2 modulates autophagy" "2" "0" "0.984" "0.991" "0.985" "1.007" "0.995" "0.923" "0.927" "0.977" "1.011" "1288.2" "1267.7" "1276.0" "1268.8" "1297.5" "1281.9" "1189.2" "1194.1" "1258.8" "1301.9" "" "" "" "" "" "" "" "" "" "" "1207.1" "1049.0" "1184.6" "980.8" "1106.0" "1224.7" "1086.6" "1060.3" "1258.8" "1253.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3851558283081104520" "False" "High" "IsMasterProtein" "Q14145" "Kelch-like ECH-associated protein 1 OS=Homo sapiens OX=9606 GN=KEAP1 PE=1 SV=2" "0.000" "False" "15.768" "9" "5" "6" "5" "624" "69.6" "6.44" "15.32" "5" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00651, Pf01344, Pf07707" "9817" "ENSG00000079999" "KEAP1" "B3KPD5; hsa:9817; Q14145; Q6LEP0; Q8WTX1; Q9BPY9" "Quercetin and Nf-kB / AP-1 induced apoptosis; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Hereditary leiomyomatosis and renal cell carcinoma pathway; NRF2-ARE regulation; Head and neck squamous cell carcinoma; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway" "Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Neddylation; KEAP1-NFE2L2 pathway; Potential therapeutics for SARS; Nuclear events mediated by NFE2L2" "16" "0" "0.996" "1.266" "1.846" "1.170" "1.382" "1.361" "1.134" "1.424" "1.288" "22.8" "22.7" "28.9" "42.1" "26.7" "31.5" "31.0" "25.8" "32.5" "29.4" "" "" "" "" "" "" "" "" "" "" "21.4" "18.8" "26.8" "32.5" "22.7" "30.1" "28.3" "23.0" "32.5" "28.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1681644365065118187" "False" "High" "IsMasterProtein" "Q8IVS2" "Malonyl-CoA-acyl carrier protein transacylase, mitochondrial OS=Homo sapiens OX=9606 GN=MCAT PE=1 SV=2" "0.000" "False" "15.762" "14" "6" "6" "6" "390" "42.9" "8.72" "18.09" "6" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00698" "27349" "ENSG00000100294" "MCAT" "B0QY72; O95510; O95511; Q8IVS2" "Mitochondrial fatty acid synthesis pathway" "Mitochondrial Fatty Acid Beta-Oxidation" "2" "0" "1.017" "1.075" "0.985" "1.061" "1.086" "1.052" "1.060" "1.055" "1.038" "715.2" "727.2" "768.5" "704.6" "758.9" "776.4" "752.6" "758.5" "754.8" "742.1" "" "" "" "" "" "" "" "" "" "" "670.2" "601.8" "713.5" "544.7" "646.8" "741.8" "687.7" "673.5" "754.8" "714.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1288043512151873046" "False" "High" "IsMasterProtein" "Q8WU39" "Marginal zone B- and B1-cell-specific protein OS=Homo sapiens OX=9606 GN=MZB1 PE=1 SV=1" "0.000" "False" "15.754" "34" "4" "10" "4" "189" "20.7" "5.57" "27.92" "4" "cell organization and biogenesis;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "" "Pf11938" "51237" "ENSG00000170476" "MZB1" "D2IYS0; hsa:51237; Q7Z6N2; Q8WU39; Q96RL5; Q9P0T3" "" "" "0" "0" "0.999" "0.992" "0.889" "0.997" "0.995" "0.904" "0.981" "0.958" "0.973" "829.6" "828.5" "822.7" "737.9" "826.9" "825.7" "750.0" "814.1" "794.7" "807.6" "" "" "" "" "" "" "" "" "" "" "777.3" "685.6" "763.8" "570.5" "704.8" "788.9" "685.3" "722.9" "794.7" "777.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4959898328745925415" "False" "High" "IsMasterProtein" "Q6IN84" "rRNA methyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=MRM1 PE=1 SV=1" "0.000" "False" "15.745" "16" "6" "8" "6" "353" "38.6" "7.94" "23.13" "6" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00588, Pf08032" "79922" "ENSG00000274853; ENSG00000278619" "MRM1" "A8K8E2; hsa:79922; Q6IN84; Q96GK2; Q9H664" "17q12 copy number variation syndrome" "rRNA modification in the mitochondrion" "2" "0" "1.090" "1.029" "1.136" "1.185" "1.084" "1.202" "1.142" "1.242" "1.040" "413.3" "450.5" "425.2" "469.4" "489.7" "448.1" "496.6" "472.0" "513.4" "430.0" "" "" "" "" "" "" "" "" "" "" "387.3" "372.8" "394.8" "362.9" "417.4" "428.1" "453.8" "419.1" "513.4" "414.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9158883592383283846" "False" "High" "IsMasterProtein" "P60983" "Glia maturation factor beta OS=Homo sapiens OX=9606 GN=GMFB PE=1 SV=2" "0.000" "False" "15.731" "43" "6" "6" "5" "142" "16.7" "5.29" "14.71" "6" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241" "2764" "ENSG00000197045" "GMFB" "B2R499; hsa:2764; P17774; P60983; Q9BS35" "" "" "0" "1" "1.067" "1.060" "0.950" "1.022" "1.035" "0.992" "1.019" "1.036" "1.046" "574.3" "612.6" "608.5" "545.4" "586.9" "594.5" "569.5" "585.4" "595.1" "600.4" "" "" "" "" "" "" "" "" "" "" "538.1" "506.9" "564.9" "421.7" "500.2" "568.0" "520.4" "519.8" "595.1" "578.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-579275288277334412" "False" "High" "IsMasterProtein" "P46736" "Lys-63-specific deubiquitinase BRCC36 OS=Homo sapiens OX=9606 GN=BRCC3 PE=1 SV=2" "0.000" "False" "15.717" "22" "5" "7" "5" "316" "36.0" "5.92" "24.00" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01398, Pf18110" "79184" "ENSG00000185515" "BRCC3" "A6QRF8; A6QRF9; A8MUX5; A8MWH0; A9Z1Y0; A9Z1Y5; B1B062; B4DQN7; hsa:79184; P46736; Q16107; Q53YX5; Q9BTZ6" "5q35 copy number variation" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs" "6" "0" "0.962" "0.994" "1.036" "1.002" "0.975" "1.036" "1.031" "0.937" "0.959" "1082.3" "1041.5" "1075.7" "1120.9" "1084.0" "1054.8" "1121.6" "1115.9" "1014.2" "1038.0" "" "" "" "" "" "" "" "" "" "" "1014.1" "861.9" "998.7" "866.5" "923.9" "1007.8" "1024.8" "990.8" "1014.2" "999.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5593036104782441701" "False" "High" "IsMasterProtein" "Q8NCF5" "NFATC2-interacting protein OS=Homo sapiens OX=9606 GN=NFATC2IP PE=1 SV=1" "0.000" "False" "15.710" "17" "5" "8" "5" "419" "45.8" "6.60" "25.74" "5" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf11976" "84901" "ENSG00000176953" "NFATC2IP" "B7Z4G5; hsa:84901; Q66K34; Q6NVK1; Q8NCF5; Q8NFR2; Q96ST9" "16p11.2 distal deletion syndrome" "" "1" "0" "1.096" "1.143" "1.152" "1.214" "1.171" "1.155" "1.163" "1.159" "1.180" "209.3" "229.5" "239.2" "241.2" "254.1" "245.2" "241.9" "243.4" "242.6" "247.1" "" "" "" "" "" "" "" "" "" "" "196.2" "189.9" "222.1" "186.4" "216.6" "234.3" "221.0" "216.1" "242.6" "237.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3935713179938084537" "False" "High" "IsMasterProtein" "Q96HP4" "Oxidoreductase NAD-binding domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OXNAD1 PE=1 SV=1" "0.000" "False" "15.696" "22" "7" "7" "7" "312" "34.8" "8.37" "16.73" "7" "" "" "other molecular function" "Pf00175" "92106" "ENSG00000154814" "OXNAD1" "hsa:92106; Q2HYC7; Q59FA4; Q96HP4" "" "" "0" "0" "1.031" "0.986" "1.060" "1.031" "1.043" "1.005" "0.999" "0.952" "1.026" "647.6" "667.7" "638.3" "686.2" "667.8" "675.2" "650.9" "646.7" "616.3" "664.6" "" "" "" "" "" "" "" "" "" "" "606.8" "552.5" "592.6" "530.5" "569.3" "645.1" "594.8" "574.2" "616.3" "639.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8476150003951297336" "False" "High" "IsMasterProtein" "Q96KG9" "N-terminal kinase-like protein OS=Homo sapiens OX=9606 GN=SCYL1 PE=1 SV=1" "0.000" "False" "15.693" "7" "6" "8" "6" "808" "89.6" "6.30" "24.84" "6" "stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "57410" "ENSG00000142186" "SCYL1" "A6NJF1; hsa:57410; Q96G50; Q96KG8; Q96KG9; Q96KH1; Q9HAW5; Q9HBL3; Q9NR53" "" "" "0" "0" "1.047" "1.063" "1.078" "1.153" "1.056" "1.040" "0.996" "0.937" "1.036" "282.1" "295.3" "299.9" "304.1" "325.3" "297.9" "293.4" "281.1" "264.3" "292.4" "" "" "" "" "" "" "" "" "" "" "264.3" "244.4" "278.4" "235.1" "277.3" "284.6" "268.1" "249.6" "264.3" "281.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7071014728097244949" "False" "High" "IsMasterProtein" "Q9BW27" "Nuclear pore complex protein Nup85 OS=Homo sapiens OX=9606 GN=NUP85 PE=1 SV=1" "0.000" "False" "15.680" "7" "5" "5" "5" "656" "75.0" "5.55" "17.42" "5" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07575" "79902" "ENSG00000125450" "NUP85" "B4DMQ3; B4DPW1; hsa:79902; Q8NDI4; Q9BW27; Q9H9U1" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; SARS-CoV-2 activates/modulates innate and adaptive immune responses; tRNA processing in the nucleus; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation" "35" "0" "0.998" "1.049" "1.011" "1.013" "1.021" "1.052" "0.954" "0.993" "0.996" "1002.5" "1000.9" "1052.0" "1013.5" "1015.8" "1023.6" "1055.0" "956.5" "995.5" "998.7" "" "" "" "" "" "" "" "" "" "" "939.4" "828.2" "976.6" "783.5" "865.8" "977.9" "964.0" "849.3" "995.5" "961.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7964397888877464485" "False" "High" "IsMasterProtein" "P50897" "Palmitoyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=PPT1 PE=1 SV=1" "0.000" "False" "15.677" "20" "5" "6" "5" "306" "34.2" "6.52" "20.02" "5" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02089" "5538" "ENSG00000131238" "PPT1" "B4DY24; hsa:5538; P50897; Q6FGQ4" "" "Fatty acyl-CoA biosynthesis" "1" "0" "0.979" "1.082" "1.043" "1.079" "1.029" "1.039" "1.184" "1.082" "1.087" "332.1" "325.2" "359.5" "346.4" "358.3" "341.9" "345.2" "393.1" "359.4" "361.0" "" "" "" "" "" "" "" "" "" "" "311.2" "269.1" "333.7" "267.8" "305.4" "326.6" "315.4" "349.1" "359.4" "347.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8650406954565681421" "False" "High" "IsMasterProtein" "P48426" "Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha OS=Homo sapiens OX=9606 GN=PIP4K2A PE=1 SV=2" "0.000" "False" "15.673" "14" "5" "6" "1" "406" "46.2" "6.99" "15.80" "5" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf01504" "5305" "ENSG00000150867" "PIP4K2A" "B0YJ66; B4DGX2; D3DRV1; hsa:5305; P48426; P53807; Q5VUX3" "Regulation of actin cytoskeleton; G13 signaling pathway" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "6" "0" "0.947" "0.962" "1.128" "0.969" "0.975" "0.977" "0.912" "0.925" "0.927" "275.9" "261.4" "265.3" "311.2" "267.2" "268.9" "269.5" "251.5" "255.0" "255.7" "" "" "" "" "" "" "" "" "" "" "258.5" "216.3" "246.3" "240.6" "227.8" "256.9" "246.3" "223.3" "255.0" "246.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6821127370945399140" "False" "High" "IsMasterProtein" "Q5JVF3" "PCI domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PCID2 PE=1 SV=2" "0.000" "False" "15.671" "15" "7" "11" "7" "399" "46.0" "8.53" "23.25" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01399" "55795" "ENSG00000126226" "PCID2" "A6NK09; hsa:55795; Q3ZCX1; Q5JVF3; Q5TC57; Q5TC58; Q9H7K1; Q9HBZ7; Q9NUK6; Q9NVY1; Q9NW44; Q9NWH3" "" "" "0" "0" "0.965" "1.014" "0.992" "1.066" "1.001" "1.030" "1.024" "0.956" "1.007" "580.6" "560.4" "588.8" "576.2" "619.0" "581.2" "597.9" "594.4" "554.9" "584.4" "" "" "" "" "" "" "" "" "" "" "544.0" "463.7" "546.6" "445.4" "527.6" "555.3" "546.3" "527.8" "554.9" "562.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4947084340596136770" "False" "High" "IsMasterProtein" "Q8TF05" "Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PPP4R1 PE=1 SV=1" "0.000" "False" "15.666" "5" "6" "8" "6" "950" "106.9" "4.77" "25.63" "6" "protein metabolism;other metabolic processes;signal transduction" "other cell component" "enzyme regulator activity" "Pf02985, Pf15017" "9989" "ENSG00000154845" "PPP4R1" "hsa:9989; Q8TF05; Q99774; Q9UNQ7" "16p11.2 proximal deletion syndrome" "" "1" "0" "1.007" "0.987" "0.975" "1.029" "0.972" "0.930" "0.917" "0.932" "0.979" "1058.3" "1065.7" "1044.3" "1031.6" "1088.8" "1028.9" "984.0" "970.4" "986.8" "1036.4" "" "" "" "" "" "" "" "" "" "" "991.6" "881.9" "969.5" "797.5" "928.0" "983.0" "899.1" "861.6" "986.8" "997.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6809936595777039335" "False" "High" "IsMasterProtein" "Q69YN4" "Protein virilizer homolog OS=Homo sapiens OX=9606 GN=VIRMA PE=1 SV=2" "0.000" "False" "15.650" "3" "7" "8" "7" "1812" "201.9" "5.01" "21.32" "7" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf15912" "25962" "ENSG00000164944" "VIRMA" "hsa:25962; Q2M1N0; Q69YN4; Q6AHX9; Q6NT78; Q7Z6C7; Q8IXH4; Q9BTH4; Q9H9C9; Q9NWR3; Q9P2B8; Q9UFW1" "" "" "0" "0" "1.013" "1.030" "1.252" "1.208" "1.110" "1.543" "1.564" "1.551" "1.239" "373.6" "378.4" "384.9" "467.5" "451.2" "414.8" "576.4" "584.1" "579.5" "462.7" "" "" "" "" "" "" "" "" "" "" "350.0" "313.1" "357.3" "361.4" "384.6" "396.3" "526.7" "518.7" "579.5" "445.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2645630736488314632" "False" "High" "IsMasterProtein" "P04080" "Cystatin-B OS=Homo sapiens OX=9606 GN=CSTB PE=1 SV=2" "0.000" "False" "15.644" "24" "2" "7" "2" "98" "11.1" "7.56" "27.32" "2" "other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00031" "1476" "ENSG00000160213" "CSTB" "hsa:1476; P04080" "" "Neutrophil degranulation" "1" "0" "0.924" "1.010" "0.700" "0.910" "1.022" "0.800" "0.968" "0.966" "0.936" "1103.9" "1020.3" "1114.8" "773.2" "1004.4" "1128.3" "882.9" "1068.5" "1066.2" "1033.2" "" "" "" "" "" "" "" "" "" "" "1034.3" "844.3" "1034.9" "597.8" "856.1" "1078.0" "806.7" "948.7" "1066.2" "994.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3247337186477247949" "False" "High" "IsMasterProtein" "Q9UQR1" "Zinc finger protein 148 OS=Homo sapiens OX=9606 GN=ZNF148 PE=1 SV=2" "0.000" "False" "15.618" "8" "5" "6" "5" "794" "88.9" "6.48" "16.01" "5" "stress response;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "7707" "ENSG00000163848" "ZNF148" "D3DN27; O00389; O43591; Q58EY5; Q6PJ98; Q9UQR1" "" "" "0" "0" "1.030" "0.998" "1.041" "1.110" "0.994" "0.991" "1.075" "1.021" "1.021" "818.7" "843.3" "817.0" "852.2" "908.3" "814.1" "810.9" "880.3" "835.7" "836.2" "" "" "" "" "" "" "" "" "" "" "767.1" "697.8" "758.5" "658.8" "774.2" "777.8" "741.0" "781.6" "835.7" "805.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8303897606251246511" "False" "High" "IsMasterProtein" "Q96HW7" "Integrator complex subunit 4 OS=Homo sapiens OX=9606 GN=INTS4 PE=1 SV=2" "0.000" "False" "15.594" "6" "6" "6" "6" "963" "108.1" "6.44" "17.79" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf13646, Pf20168" "92105" "ENSG00000149262" "INTS4" "hsa:92105; Q2YD62; Q6PJG4; Q7Z4E7; Q96G32; Q96GA1; Q96HW7; Q9BRC0" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "0.986" "0.964" "1.040" "1.072" "1.007" "1.002" "1.050" "1.074" "1.038" "436.0" "429.9" "420.5" "453.4" "467.3" "439.0" "436.8" "457.9" "468.5" "452.5" "" "" "" "" "" "" "" "" "" "" "408.6" "355.7" "390.4" "350.5" "398.3" "419.5" "399.1" "406.5" "468.5" "435.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-486365272632798294" "False" "High" "IsMasterProtein" "Q8WUW1" "Protein BRICK1 OS=Homo sapiens OX=9606 GN=BRK1 PE=1 SV=1" "0.000" "False" "15.593" "47" "5" "8" "5" "75" "8.7" "5.45" "23.96" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "" "55845" "ENSG00000254999" "BRK1" "B2R5E2; hsa:55845; Q8WUW1; Q9P082" "Regulation of actin cytoskeleton" "RAC1 GTPase cycle; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle" "8" "0" "1.066" "1.027" "0.969" "0.962" "0.958" "0.966" "1.051" "1.063" "0.959" "494.6" "527.3" "508.1" "479.3" "475.8" "473.7" "477.7" "519.8" "525.8" "474.3" "" "" "" "" "" "" "" "" "" "" "463.5" "436.3" "471.7" "370.5" "405.6" "452.6" "436.4" "461.5" "525.8" "456.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7708170732071910709" "False" "High" "IsMasterProtein" "O96013" "Serine/threonine-protein kinase PAK 4 OS=Homo sapiens OX=9606 GN=PAK4 PE=1 SV=1" "0.000" "False" "15.587" "8" "5" "7" "5" "591" "64.0" "9.73" "22.68" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00786" "10298" "ENSG00000130669" "PAK4" "B4DGG6; hsa:10298; O96013; Q8N4E1; Q8NCH5; Q8NDE3; Q9BU33; Q9ULS8" "Integrin-mediated cell adhesion; Focal adhesion; MET in type 1 papillary renal cell carcinoma; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 22q11.2 copy number variation syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; TROP2 regulatory signaling; ErbB signaling pathway" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Activation of RAC1; RHOH GTPase cycle" "25" "0" "1.013" "1.002" "1.035" "1.021" "1.005" "1.044" "0.966" "1.031" "1.023" "133.1" "134.8" "133.3" "137.7" "135.9" "133.7" "138.9" "128.5" "137.2" "136.2" "" "" "" "" "" "" "" "" "" "" "124.7" "111.6" "123.8" "106.4" "115.8" "127.7" "126.9" "114.1" "137.2" "131.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2331175161516182807" "False" "High" "IsMasterProtein" "Q6YN16" "Hydroxysteroid dehydrogenase-like protein 2 OS=Homo sapiens OX=9606 GN=HSDL2 PE=1 SV=1" "0.000" "False" "15.575" "11" "5" "5" "5" "418" "45.4" "7.99" "17.71" "5" "" "mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00106, Pf02036" "84263" "ENSG00000119471" "HSDL2" "A8K1L4; A8K8X1; A8MSV3; hsa:84263; Q658M8; Q6YN16; Q9BT58" "" "" "0" "0" "1.058" "1.083" "1.065" "1.065" "1.071" "1.042" "0.962" "1.038" "1.083" "480.0" "507.7" "519.7" "511.1" "511.4" "514.3" "500.2" "461.9" "498.4" "520.1" "" "" "" "" "" "" "" "" "" "" "449.8" "420.2" "482.4" "395.1" "435.9" "491.4" "457.1" "410.1" "498.4" "500.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4952075756115425488" "False" "High" "IsMasterProtein" "Cont_P34955" "Alpha-1-antiproteinase OS=Bos taurus OX=9913 GN=SERPINA1 PE=1 SV=1" "0.000" "True" "15.555" "13" "6" "7" "6" "416" "46.1" "6.52" "23.30" "6" "" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00079" "109575576; 280699" "ENSBIXG00000014418; ENSBIXG00005018236; ENSBTAG00000018843" "SERPINA1" "A0A4W2DYT6; A0A6P5DQE7; biu:109575576; bta:280699; P34955; Q3SZS3" "Complement and coagulation cascades; NRF2 pathway" "Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo concentration in the ER; COPII-mediated vesicle transport" "8" "0" "1.261" "0.970" "1.020" "1.339" "1.276" "1.197" "1.365" "1.469" "1.193" "884.7" "1115.5" "858.3" "902.2" "1184.5" "1128.8" "1059.2" "1207.3" "1300.0" "1055.8" "" "" "" "" "" "" "" "" "" "" "829.0" "923.0" "796.8" "697.5" "1009.6" "1078.5" "967.8" "1072.0" "1300.0" "1016.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9192930488046834202" "False" "High" "IsMasterProtein" "P25789" "Proteasome subunit alpha type-4 OS=Homo sapiens OX=9606 GN=PSMA4 PE=1 SV=1" "0.000" "False" "15.549" "16" "5" "14" "5" "261" "29.5" "7.72" "37.14" "5" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5685" "ENSG00000041357" "PSMA4" "D3DW86; hsa:5685; P25789; Q53XP2; Q567Q5; Q8TBD1" "Proteasome degradation; Alzheimer's disease and miRNA effects; Exercise-induced circadian regulation; Alzheimer's disease" "Degradation of DVL; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "0.984" "0.937" "0.956" "0.948" "0.976" "0.924" "0.971" "0.941" "0.907" "1157.1" "1138.7" "1084.3" "1106.6" "1097.1" "1129.2" "1069.2" "1123.1" "1088.9" "1049.5" "" "" "" "" "" "" "" "" "" "" "1084.2" "942.3" "1006.7" "855.4" "935.2" "1078.8" "976.9" "997.2" "1088.9" "1010.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5626279923656509616" "False" "High" "IsMasterProtein" "P25325" "3-mercaptopyruvate sulfurtransferase OS=Homo sapiens OX=9606 GN=MPST PE=1 SV=3" "0.000" "False" "15.518" "18" "5" "7" "5" "297" "33.2" "6.60" "22.75" "5" "other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00581" "4357" "ENSG00000128309" "MPST" "A8MZ34; B3KP52; hsa:4357; J3KPV7; O75750; P25325; Q6FHN9" "Trans-sulfuration pathway; Amino acid metabolism" "Degradation of cysteine and homocysteine" "3" "0" "0.915" "0.906" "0.932" "0.957" "0.943" "0.945" "0.885" "0.851" "0.926" "352.6" "322.6" "319.5" "328.4" "337.2" "332.6" "333.0" "312.1" "299.9" "326.3" "" "" "" "" "" "" "" "" "" "" "330.3" "267.0" "296.6" "253.9" "287.4" "317.8" "304.3" "277.1" "299.9" "314.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-815619529761870657" "False" "High" "IsMasterProtein" "Q6P996" "Pyridoxal-dependent decarboxylase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PDXDC1 PE=1 SV=2" "0.000" "False" "15.513" "9" "7" "7" "7" "788" "86.7" "5.38" "19.46" "7" "other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf00282" "23042" "ENSG00000179889; ENSG00000275498" "PDXDC1" "B4DR55; B4DSL3; E7EMH5; E7EPL4; H3BNZ1; hsa:23042; O00236; Q4F6X7; Q6P996; Q6PID7; Q86YF1; Q8N4Q9; Q8TBS5" "" "" "0" "0" "0.939" "0.997" "1.054" "1.087" "1.032" "0.964" "0.890" "0.944" "1.015" "527.5" "495.2" "526.1" "555.9" "573.3" "544.4" "508.6" "469.5" "497.8" "535.3" "" "" "" "" "" "" "" "" "" "" "494.3" "409.8" "488.5" "429.7" "488.6" "520.1" "464.7" "416.8" "497.8" "515.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "916743004623214960" "False" "High" "IsMasterProtein" "P62266" "Small ribosomal subunit protein uS12 OS=Homo sapiens OX=9606 GN=RPS23 PE=1 SV=3" "0.000" "False" "15.510" "26" "4" "7" "4" "143" "15.8" "10.49" "20.61" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00164" "6228" "ENSG00000186468" "RPS23" "hsa:6228; P39028; P62266; Q6IB08" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Formation of the ternary complex, and subsequently, the 43S complex; Response of EIF2AK4 (GCN2) to amino acid deficiency; Protein hydroxylation; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "20" "0" "1.082" "1.054" "1.048" "1.090" "1.045" "1.055" "1.079" "1.156" "1.064" "414.4" "448.5" "436.8" "434.3" "451.5" "433.0" "437.2" "447.0" "479.0" "440.9" "" "" "" "" "" "" "" "" "" "" "388.3" "371.1" "405.5" "335.7" "384.9" "413.7" "399.5" "396.9" "479.0" "424.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "410623999248744867" "False" "High" "IsMasterProtein" "Q6PKG0" "La-related protein 1 OS=Homo sapiens OX=9606 GN=LARP1 PE=1 SV=2" "0.000" "False" "15.499" "5" "6" "6" "6" "1096" "123.4" "8.82" "18.58" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf05383, Pf21071" "23367" "ENSG00000155506" "LARP1" "hsa:23367; O94836; Q6PKG0; Q8N4M2; Q8NB73; Q9UFD7" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "4" "0" "1.055" "1.002" "1.177" "1.183" "1.075" "1.243" "1.315" "1.297" "1.219" "554.6" "585.0" "556.0" "652.8" "656.1" "596.1" "689.4" "729.1" "719.4" "676.2" "" "" "" "" "" "" "" "" "" "" "519.7" "484.1" "516.1" "504.6" "559.2" "569.5" "629.9" "647.4" "719.4" "651.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3614438977501336635" "False" "High" "IsMasterProtein" "Q92558" "Actin-binding protein WASF1 OS=Homo sapiens OX=9606 GN=WASF1 PE=1 SV=1" "0.000" "False" "15.496" "11" "6" "6" "6" "559" "61.6" "6.46" "19.87" "6" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "8936" "ENSG00000112290" "WASF1" "E1P5F2; hsa:8936; Q5SZK7; Q92558" "VEGFA-VEGFR2 signaling; Regulation of actin cytoskeleton" "RAC1 GTPase cycle; RAC3 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway" "8" "0" "1.025" "1.088" "1.081" "1.055" "1.059" "1.024" "1.047" "1.045" "1.131" "633.6" "649.5" "689.5" "684.7" "668.8" "671.2" "649.1" "663.5" "662.4" "716.5" "" "" "" "" "" "" "" "" "" "" "593.7" "537.4" "640.1" "529.3" "570.0" "641.3" "593.1" "589.1" "662.4" "689.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4878144000314540155" "False" "High" "IsMasterProtein" "Q9NWU5" "Large ribosomal subunit protein uL22m OS=Homo sapiens OX=9606 GN=MRPL22 PE=1 SV=1" "0.000" "False" "15.488" "28" "6" "8" "6" "206" "23.6" "9.94" "21.49" "6" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00237" "29093" "ENSG00000082515" "MRPL22" "A6NGJ8; hsa:29093; Q5H9Q1; Q96Q51; Q9NWU5; Q9P006" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.009" "1.073" "1.158" "1.108" "1.108" "1.099" "1.070" "1.082" "1.081" "759.9" "767.1" "815.2" "879.9" "841.9" "842.0" "834.9" "813.5" "822.4" "821.4" "" "" "" "" "" "" "" "" "" "" "712.1" "634.8" "756.8" "680.2" "717.6" "804.5" "762.9" "722.3" "822.4" "790.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4323681854308555372" "False" "High" "IsMasterProtein" "Q12830" "Nucleosome-remodeling factor subunit BPTF OS=Homo sapiens OX=9606 GN=BPTF PE=1 SV=3" "0.000" "False" "15.484" "2" "5" "5" "5" "3046" "338.1" "6.54" "14.26" "5" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf02791, Pf15613" "2186" "ENSG00000171634" "BPTF" "hsa:2186; Q12830; Q6NX67; Q7Z7D6; Q9UIG2" "Endoderm differentiation; 16p11.2 proximal deletion syndrome" "" "2" "0" "1.042" "1.072" "1.013" "1.061" "0.912" "0.961" "0.886" "0.877" "0.960" "383.6" "399.8" "411.3" "388.5" "407.0" "349.9" "368.8" "339.8" "336.5" "368.4" "" "" "" "" "" "" "" "" "" "" "359.4" "330.8" "381.8" "300.3" "346.9" "334.3" "337.0" "301.7" "336.5" "354.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4123477520333659496" "False" "High" "IsMasterProtein" "Q7Z4G4" "tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens OX=9606 GN=TRMT11 PE=1 SV=1" "0.000" "False" "15.479" "13" "6" "6" "6" "463" "53.4" "7.78" "17.71" "6" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "nucleic acid binding activity" "Pf01170" "60487" "ENSG00000066651" "TRMT11" "E1P570; hsa:60487; Q5JY11; Q6PGQ5; Q7Z4G4; Q9HC13" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.013" "0.953" "1.032" "0.977" "0.982" "0.993" "0.940" "1.004" "0.942" "399.6" "404.6" "380.6" "412.4" "390.4" "392.5" "396.9" "375.5" "401.2" "376.4" "" "" "" "" "" "" "" "" "" "" "374.4" "334.8" "353.4" "318.8" "332.8" "375.0" "362.7" "333.4" "401.2" "362.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819630258189506626" "False" "High" "IsMasterProtein" "P02792" "Ferritin light chain OS=Homo sapiens OX=9606 GN=FTL PE=1 SV=2" "0.000" "False" "15.454" "25" "3" "4" "3" "175" "20.0" "5.78" "17.49" "3" "transport;other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00210" "2512" "ENSG00000087086" "FTL" "B2R4B9; hsa:2512; P02792; Q6IBT7; Q7Z2W1; Q86WI9; Q8WU07; Q96AU9; Q96CU0; Q9BTZ8" "Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Iron metabolism disorders" "Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Iron uptake and transport; Scavenging by Class A Receptors" "9" "0" "1.049" "0.985" "1.251" "1.051" "0.915" "1.108" "0.990" "0.977" "1.021" "199.6" "209.4" "196.7" "249.6" "209.8" "182.7" "221.3" "197.7" "194.9" "203.8" "" "" "" "" "" "" "" "" "" "" "187.0" "173.3" "182.6" "193.0" "178.9" "174.6" "202.2" "175.6" "194.9" "196.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-693009755778798309" "False" "High" "IsMasterProtein" "O75396" "Vesicle-trafficking protein SEC22b OS=Homo sapiens OX=9606 GN=SEC22B PE=1 SV=5" "0.000" "False" "15.447" "28" "5" "5" "5" "215" "24.7" "8.51" "17.59" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00957, Pf13774" "9554" "ENSG00000265808" "SEC22B" "A8K1G0; hsa:9554; O75396" "" "COPI-dependent Golgi-to-ER retrograde traffic; ER-Phagosome pathway; COPII-mediated vesicle transport; Cargo concentration in the ER" "4" "0" "1.008" "1.031" "1.051" "1.062" "1.061" "1.074" "1.080" "1.110" "1.059" "862.5" "869.2" "889.7" "906.3" "916.4" "915.3" "926.2" "931.7" "957.6" "913.5" "" "" "" "" "" "" "" "" "" "" "808.2" "719.3" "826.0" "700.6" "781.1" "874.5" "846.3" "827.2" "957.6" "879.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6693318422199107583" "False" "High" "IsMasterProtein" "Q9HBI0" "Gamma-parvin OS=Homo sapiens OX=9606 GN=PARVG PE=1 SV=1" "0.000" "False" "15.444" "15" "5" "6" "5" "331" "37.5" "5.49" "16.46" "5" "cell adhesion;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00307" "64098" "ENSG00000138964" "PARVG" "B4DDW5; E7EVM6; hsa:64098; Q9BQX5; Q9HBI0; Q9NSG1" "Focal adhesion" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2647028449518715682" "False" "High" "IsMasterProtein" "P16383" "Intron Large complex component GCFC2 OS=Homo sapiens OX=9606 GN=GCFC2 PE=1 SV=2" "0.000" "False" "15.439" "7" "6" "7" "6" "781" "89.3" "5.99" "20.66" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf07842" "6936" "ENSG00000005436" "GCFC2" "A4UHQ8; A4UHQ9; hsa:6936; O95032; P16383; Q53TY0; Q6P2F2" "" "mRNA Splicing - Major Pathway" "1" "0" "1.025" "1.047" "1.050" "1.004" "0.979" "0.989" "1.004" "1.003" "1.003" "856.4" "877.8" "896.8" "899.0" "859.5" "838.4" "846.6" "859.5" "858.5" "858.9" "" "" "" "" "" "" "" "" "" "" "802.4" "726.4" "832.6" "694.9" "732.6" "801.0" "773.6" "763.1" "858.5" "827.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3876256361286906855" "False" "High" "IsMasterProtein" "P62269" "Small ribosomal subunit protein uS13 OS=Homo sapiens OX=9606 GN=RPS18 PE=1 SV=3" "0.000" "False" "15.439" "31" "5" "5" "5" "152" "17.7" "10.99" "15.88" "5" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00416" "6222" "ENSG00000096150; ENSG00000223367; ENSG00000226225; ENSG00000231500; ENSG00000235650" "RPS18" "hsa:6222; P25232; P62269; Q5SUJ3; Q6IPF8" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "1.097" "1.162" "1.270" "1.172" "1.154" "1.563" "1.319" "1.304" "1.219" "295.6" "324.2" "343.5" "375.5" "346.6" "341.3" "462.0" "390.1" "385.5" "360.5" "" "" "" "" "" "" "" "" "" "" "277.0" "268.3" "318.9" "290.3" "295.4" "326.1" "422.1" "346.4" "385.5" "347.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1703725255333180782" "False" "High" "IsMasterProtein" "O14530" "Thioredoxin domain-containing protein 9 OS=Homo sapiens OX=9606 GN=TXNDC9 PE=1 SV=2" "0.000" "False" "15.434" "27" "7" "9" "7" "226" "26.5" "5.88" "25.27" "7" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf00085" "10190" "ENSG00000115514" "TXNDC9" "B2R9G8; D3DVI4; hsa:10190; O14530; Q53HG4; Q53RV8; Q6NSF5; Q8TB70; Q9BRU6" "" "" "0" "0" "0.936" "0.952" "0.988" "0.990" "1.027" "0.901" "0.989" "0.929" "1.006" "2246.8" "2102.9" "2139.0" "2219.7" "2225.2" "2307.8" "2023.9" "2222.2" "2087.2" "2260.9" "" "" "" "" "" "" "" "" "" "" "2105.2" "1740.1" "1985.8" "1715.9" "1896.7" "2204.9" "1849.3" "1973.1" "2087.2" "2176.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7101780835120275737" "False" "High" "IsMasterProtein" "Q9Y3Q8" "TSC22 domain family protein 4 OS=Homo sapiens OX=9606 GN=TSC22D4 PE=1 SV=2" "0.000" "False" "15.429" "15" "6" "6" "4" "395" "41.0" "7.21" "18.03" "6" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf01166" "81628" "ENSG00000166925" "TSC22D4" "A4D2C3; A8MWR6; D6W5V9; hsa:81628; Q9Y3Q8" "" "" "0" "0" "1.132" "1.025" "1.050" "1.013" "1.069" "0.985" "0.921" "0.876" "0.841" "256.6" "290.6" "263.0" "269.5" "259.9" "274.3" "252.7" "236.3" "224.8" "215.7" "" "" "" "" "" "" "" "" "" "" "240.5" "240.5" "244.2" "208.3" "221.5" "262.1" "230.9" "209.8" "224.8" "207.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7029277553794243506" "False" "High" "IsMasterProtein" "P61244" "Protein max OS=Homo sapiens OX=9606 GN=MAX PE=1 SV=1" "0.000" "False" "15.424" "34" "6" "7" "6" "160" "18.3" "6.30" "16.08" "6" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "4149" "ENSG00000125952" "MAX" "A6NH73; A8K265; A8K4G4; A8K824; hsa:4149; P25912; P52163; P61244; Q14803; Q96CY8" "B cell receptor signaling pathway; Pathways affected in adenoid cystic carcinoma; MAPK signaling pathway; p38 MAPK signaling pathway; Small cell lung cancer; Pleural mesothelioma; 5q35 copy number variation" "Transcriptional Regulation by E2F6; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry" "11" "0" "1.048" "1.037" "1.052" "1.022" "1.051" "1.015" "0.942" "1.015" "1.025" "519.8" "544.6" "539.0" "546.6" "531.1" "546.3" "527.6" "489.8" "527.8" "532.6" "" "" "" "" "" "" "" "" "" "" "487.0" "450.7" "500.3" "422.5" "452.7" "521.9" "482.0" "434.8" "527.8" "512.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5954226143684266914" "False" "High" "IsMasterProtein" "P10398" "Serine/threonine-protein kinase A-Raf OS=Homo sapiens OX=9606 GN=ARAF PE=1 SV=2" "0.000" "False" "15.424" "8" "5" "7" "3" "606" "67.5" "9.01" "22.07" "5" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00130, Pf02196, Pf07714" "369" "ENSG00000078061" "ARAF" "hsa:369; P07557; P10398; Q5H9B2; Q5H9B3" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; Common pathways underlying drug addiction; Bladder cancer; MAPK signaling pathway; Embryonic stem cell pluripotency pathways; Endometrial cancer; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Fragile X syndrome; Hepatitis B infection; Melanoma; EGFR tyrosine kinase inhibitor resistance; Alzheimer's disease; Acute myeloid leukemia; ErbB signaling pathway" "Signaling by BRAF and RAF1 fusions; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "33" "0" "1.018" "0.948" "0.898" "0.961" "0.899" "0.846" "0.761" "0.839" "0.908" "302.0" "307.5" "286.2" "271.1" "290.4" "271.4" "255.5" "229.7" "253.4" "274.3" "" "" "" "" "" "" "" "" "" "" "283.0" "254.5" "265.7" "209.5" "247.5" "259.3" "233.4" "203.9" "253.4" "264.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6271968905262141895" "False" "High" "IsMasterProtein" "Q4VC31" "Protein MIX23 OS=Homo sapiens OX=9606 GN=MIX23 PE=1 SV=1" "0.000" "False" "15.402" "31" "4" "11" "4" "144" "16.6" "7.81" "36.37" "4" "" "mitochondrion" "" "Pf09774" "131076" "ENSG00000160124" "MIX23" "hsa:131076; Q32LY6; Q4VC31" "" "" "0" "0" "0.993" "0.986" "0.978" "1.067" "0.985" "1.009" "1.006" "0.920" "0.923" "981.7" "975.1" "967.7" "959.9" "1047.5" "967.2" "990.1" "988.0" "903.0" "906.4" "" "" "" "" "" "" "" "" "" "" "919.8" "806.9" "898.4" "742.0" "892.9" "924.0" "904.7" "877.2" "903.0" "872.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-10968856719763814" "False" "High" "IsMasterProtein" "P62081" "Small ribosomal subunit protein eS7 OS=Homo sapiens OX=9606 GN=RPS7 PE=1 SV=1" "0.000" "False" "15.394" "23" "5" "9" "5" "194" "22.1" "10.10" "24.82" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01251" "6201" "ENSG00000171863" "RPS7" "hsa:6201; P23821; P24818; P62081; Q57Z92; Q6IPH1" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery; rRNA modification in the nucleus and cytosol" "20" "0" "1.084" "1.162" "1.114" "1.105" "1.086" "1.344" "1.391" "1.401" "1.174" "1652.8" "1791.3" "1920.7" "1841.1" "1826.7" "1795.0" "2221.4" "2298.3" "2315.1" "1941.0" "" "" "" "" "" "" "" "" "" "" "1548.6" "1482.3" "1783.1" "1423.2" "1557.0" "1714.9" "2029.7" "2040.7" "2315.1" "1868.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9103143806185528671" "False" "High" "IsMasterProtein" "Q86UA1" "Pre-mRNA-processing factor 39 OS=Homo sapiens OX=9606 GN=PRPF39 PE=1 SV=3" "0.000" "False" "15.381" "9" "6" "7" "6" "669" "78.4" "5.40" "16.85" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "" "55015" "ENSG00000185246" "PRPF39" "hsa:55015; Q08AL1; Q08AL2; Q86UA1; Q9NUU5" "" "" "0" "0" "0.985" "0.964" "0.937" "0.946" "0.953" "0.868" "0.935" "1.038" "0.996" "387.3" "381.5" "373.2" "363.0" "366.3" "369.1" "336.3" "362.1" "402.2" "385.8" "" "" "" "" "" "" "" "" "" "" "362.9" "315.7" "346.5" "280.6" "312.2" "352.6" "307.3" "321.5" "402.2" "371.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4335544546222164902" "False" "High" "IsMasterProtein" "Q9NRX4" "14 kDa phosphohistidine phosphatase OS=Homo sapiens OX=9606 GN=PHPT1 PE=1 SV=1" "0.000" "False" "15.366" "38" "5" "9" "5" "125" "13.8" "6.07" "21.33" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf05005" "29085" "ENSG00000054148" "PHPT1" "B1AMX0; B1AMX1; hsa:29085; Q9H0Y3; Q9NRX4" "" "" "0" "0" "1.062" "1.048" "0.995" "0.921" "0.871" "0.972" "0.890" "0.919" "0.963" "603.1" "640.7" "631.9" "600.1" "555.3" "525.4" "586.0" "536.8" "554.5" "580.8" "" "" "" "" "" "" "" "" "" "" "565.1" "530.1" "586.6" "463.9" "473.3" "501.9" "535.4" "476.6" "554.5" "559.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2292844797767435028" "False" "High" "IsMasterProtein" "Q9H074" "Polyadenylate-binding protein-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAIP1 PE=1 SV=1" "0.000" "False" "15.365" "10" "6" "8" "6" "479" "53.5" "4.81" "18.30" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf02854, Pf07145" "10605" "ENSG00000172239" "PAIP1" "A6NKV8; hsa:10605; O60455; Q96B61; Q9BS63; Q9H074" "Translation factors" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "4" "0" "0.968" "0.940" "1.017" "1.004" "0.969" "0.994" "0.996" "0.898" "0.933" "531.7" "514.8" "499.5" "540.7" "533.9" "515.2" "528.7" "529.4" "477.6" "496.3" "" "" "" "" "" "" "" "" "" "" "498.2" "426.0" "463.7" "418.0" "455.1" "492.2" "483.1" "470.1" "477.6" "477.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7794813676372242912" "False" "High" "IsMasterProtein" "Q96MW5" "Conserved oligomeric Golgi complex subunit 8 OS=Homo sapiens OX=9606 GN=COG8 PE=1 SV=2" "0.000" "False" "15.358" "10" "7" "7" "7" "612" "68.4" "5.20" "20.22" "7" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi" "" "Pf04124" "84342" "ENSG00000213380" "COG8" "hsa:84342; Q0VAK2; Q8WVV6; Q96MW5; Q9H6F8" "" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "3" "0" "0.985" "0.987" "1.007" "1.014" "0.992" "1.013" "1.001" "1.020" "1.031" "708.1" "697.7" "699.2" "713.0" "718.2" "702.2" "716.9" "709.1" "721.9" "730.1" "" "" "" "" "" "" "" "" "" "" "663.4" "577.3" "649.1" "551.2" "612.1" "670.9" "655.1" "629.6" "721.9" "703.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3913128170310311305" "False" "High" "IsMasterProtein" "O00487" "26S proteasome non-ATPase regulatory subunit 14 OS=Homo sapiens OX=9606 GN=PSMD14 PE=1 SV=1" "0.000" "False" "15.356" "18" "7" "12" "7" "310" "34.6" "6.52" "30.92" "7" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01398" "10213" "ENSG00000115233" "PSMD14" "B3KNW2; hsa:10213; O00176; O00487" "Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Metalloprotease DUBs" "64" "0" "0.962" "0.957" "1.020" "0.987" "0.991" "0.949" "0.957" "1.003" "0.974" "1591.0" "1530.4" "1522.4" "1623.4" "1569.9" "1576.5" "1510.6" "1521.8" "1596.5" "1549.6" "" "" "" "" "" "" "" "" "" "" "1490.8" "1266.4" "1413.3" "1254.9" "1338.1" "1506.2" "1380.3" "1351.2" "1596.5" "1492.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2147212707680779052" "False" "High" "IsMasterProtein" "P49427" "Ubiquitin-conjugating enzyme E2 R1 OS=Homo sapiens OX=9606 GN=CDC34 PE=1 SV=2" "0.000" "False" "15.346" "20" "6" "8" "5" "236" "26.7" "4.54" "23.65" "6" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "997" "ENSG00000099804" "CDC34" "A8K689; hsa:997; P49427" "Vitamin D receptor pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "6" "0" "1.025" "1.003" "1.178" "1.088" "1.150" "1.109" "1.071" "1.050" "1.104" "280.8" "287.9" "281.6" "330.8" "305.5" "322.8" "311.3" "300.8" "294.9" "310.1" "" "" "" "" "" "" "" "" "" "" "263.1" "238.2" "261.4" "255.7" "260.4" "308.4" "284.5" "267.1" "294.9" "298.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-161088924712109766" "False" "High" "IsMasterProtein" "Q96RU2" "Ubiquitin carboxyl-terminal hydrolase 28 OS=Homo sapiens OX=9606 GN=USP28 PE=1 SV=1" "0.000" "False" "15.343" "6" "7" "7" "7" "1077" "122.4" "5.20" "18.02" "7" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443" "57646" "ENSG00000048028" "USP28" "B0YJC0; B0YJC1; hsa:57646; Q6NZX9; Q96RU2; Q9P213" "Warburg effect modulated by deubiquitinating enzymes and their substrates" "Ub-specific processing proteases" "2" "0" "1.013" "0.946" "1.096" "1.068" "1.003" "1.034" "0.981" "0.962" "1.048" "810.8" "821.6" "767.1" "888.9" "865.8" "813.4" "838.6" "795.7" "779.8" "850.0" "" "" "" "" "" "" "" "" "" "" "759.7" "679.9" "712.2" "687.2" "738.0" "777.2" "766.3" "706.5" "779.8" "818.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7186431258293956911" "False" "High" "IsMasterProtein" "Q04837" "Single-stranded DNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SSBP1 PE=1 SV=1" "0.000" "False" "15.341" "33" "5" "11" "5" "148" "17.2" "9.60" "28.34" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00436" "6742" "ENSG00000106028; ENSG00000262771" "SSBP1" "hsa:6742; Q04837" "" "Mitochondrial protein degradation; Transcriptional activation of mitochondrial biogenesis" "2" "0" "0.933" "1.024" "0.854" "0.898" "0.977" "0.763" "0.848" "0.824" "0.906" "1708.4" "1594.1" "1749.9" "1459.0" "1534.7" "1668.7" "1304.2" "1449.6" "1407.1" "1547.0" "" "" "" "" "" "" "" "" "" "" "1600.8" "1319.1" "1624.5" "1127.9" "1308.1" "1594.2" "1191.7" "1287.1" "1407.1" "1489.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6816418598839755867" "False" "High" "IsMasterProtein" "Q9NXC5" "GATOR2 complex protein MIOS OS=Homo sapiens OX=9606 GN=MIOS PE=1 SV=2" "0.000" "False" "15.324" "8" "6" "6" "6" "875" "98.5" "6.73" "14.77" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf17034, Pf21719, Pf21720" "54468" "ENSG00000164654" "MIOS" "B2RTV6; hsa:54468; O75216; Q7L551; Q9H092; Q9NXC5" "" "Amino acids regulate mTORC1" "1" "0" "0.956" "0.994" "0.997" "0.981" "0.991" "0.959" "0.918" "1.015" "1.028" "535.5" "512.2" "532.1" "533.7" "525.2" "530.8" "513.4" "491.8" "543.5" "550.4" "" "" "" "" "" "" "" "" "" "" "501.8" "423.8" "494.0" "412.6" "447.7" "507.1" "469.1" "436.6" "543.5" "529.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5740935786864817136" "False" "High" "IsMasterProtein" "Q9BRX2" "Protein pelota homolog OS=Homo sapiens OX=9606 GN=PELO PE=1 SV=2" "0.000" "False" "15.314" "14" "6" "10" "6" "385" "43.3" "6.34" "21.92" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;other molecular function" "Pf03463, Pf03464, Pf03465" "53918" "ENSG00000152684" "PELO" "hsa:53918; Q9BRX2; Q9GZS6; Q9Y306" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "" "1" "0" "0.991" "1.028" "1.005" "0.976" "1.042" "0.914" "0.908" "0.908" "0.982" "587.9" "582.9" "604.1" "590.6" "574.0" "612.5" "537.1" "533.7" "533.9" "577.5" "" "" "" "" "" "" "" "" "" "" "550.9" "482.3" "560.8" "456.6" "489.3" "585.2" "490.8" "473.8" "533.9" "556.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6030770174415932169" "False" "High" "IsMasterProtein" "P52294" "Importin subunit alpha-5 OS=Homo sapiens OX=9606 GN=KPNA1 PE=1 SV=3" "0.000" "False" "15.314" "11" "5" "5" "4" "538" "60.2" "5.01" "18.27" "5" "cell-cell signaling;cell cycle OR cell proliferation;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3836" "ENSG00000114030" "KPNA1" "D3DN93; hsa:3836; P52294; Q6IBQ9; Q9BQ56" "Ebola virus infection in host" "Apoptosis induced DNA fragmentation; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; Interferon alpha/beta signaling; Assembly of the ORC complex at the origin of replication; Integration of provirus; Inhibition of nitric oxide production" "10" "0" "1.072" "1.124" "1.129" "1.191" "1.173" "1.248" "1.208" "1.098" "1.139" "216.0" "231.5" "242.9" "244.0" "257.2" "253.3" "269.6" "261.1" "237.2" "246.1" "" "" "" "" "" "" "" "" "" "" "202.4" "191.6" "225.5" "188.6" "219.3" "242.0" "246.3" "231.8" "237.2" "237.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5704352961259904218" "False" "High" "IsMasterProtein" "Q14155" "Rho guanine nucleotide exchange factor 7 OS=Homo sapiens OX=9606 GN=ARHGEF7 PE=1 SV=2" "0.000" "False" "15.312" "7" "6" "16" "5" "803" "90.0" "7.09" "32.87" "6" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00169, Pf00307, Pf00621, Pf07653, Pf16614, Pf16615" "8874" "ENSG00000102606" "ARHGEF7" "B1ALK6; B1ALK8; hsa:8874; Q14155; Q3LIA4; Q5W9H0; Q6P9G3; Q6PII2; Q86W63; Q8N3M1" "Integrin-mediated cell adhesion; CAMKK2 pathway; Regulation of actin cytoskeleton" "RHOV GTPase cycle; RHOU GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOJ GTPase cycle; RHOQ GTPase cycle; Ephrin signaling; EGFR downregulation" "14" "0" "0.934" "0.977" "0.928" "0.955" "0.968" "0.922" "0.911" "0.943" "1.009" "1566.0" "1462.3" "1530.6" "1452.5" "1495.1" "1516.6" "1443.8" "1426.8" "1476.2" "1580.6" "" "" "" "" "" "" "" "" "" "" "1467.4" "1210.1" "1421.0" "1122.9" "1274.4" "1449.0" "1319.2" "1266.9" "1476.2" "1521.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5958960994699696402" "False" "High" "IsMasterProtein" "Q99081" "Transcription factor 12 OS=Homo sapiens OX=9606 GN=TCF12 PE=1 SV=1" "0.000" "False" "15.294" "9" "5" "5" "4" "682" "72.9" "7.02" "20.54" "5" "other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "6938" "ENSG00000140262" "TCF12" "B4E1W1; hsa:6938; Q7Z3D9; Q86TC1; Q86VM2; Q99081" "" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Myogenesis; NGF-stimulated transcription" "3" "0" "1.131" "1.128" "1.023" "1.106" "1.093" "1.087" "1.071" "1.095" "1.185" "84.1" "95.2" "95.0" "86.1" "93.1" "91.9" "91.5" "90.1" "92.1" "99.7" "" "" "" "" "" "" "" "" "" "" "78.8" "78.8" "88.2" "66.6" "79.3" "87.8" "83.6" "80.0" "92.1" "96.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1040458896990308382" "False" "High" "IsMasterProtein" "Q9Y5J7" "Mitochondrial import inner membrane translocase subunit Tim9 OS=Homo sapiens OX=9606 GN=TIMM9 PE=1 SV=1" "0.000" "False" "15.280" "47" "4" "6" "4" "89" "10.4" "7.21" "19.90" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "26520" "ENSG00000100575" "TIMM9" "B2R584; hsa:26520; Q9Y5J7" "" "Mitochondrial protein import; Mitochondrial protein degradation" "2" "0" "0.969" "1.013" "0.992" "1.029" "1.015" "1.065" "1.116" "1.065" "0.997" "1134.0" "1099.1" "1149.1" "1125.0" "1166.9" "1150.9" "1207.2" "1265.5" "1207.8" "1130.2" "" "" "" "" "" "" "" "" "" "" "1062.6" "909.5" "1066.8" "869.7" "994.6" "1099.5" "1103.1" "1123.7" "1207.8" "1088.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7798556211851200264" "False" "High" "IsMasterProtein" "Q96AX1" "Vacuolar protein sorting-associated protein 33A OS=Homo sapiens OX=9606 GN=VPS33A PE=1 SV=1" "0.000" "False" "15.275" "9" "7" "8" "7" "596" "67.6" "6.96" "21.33" "7" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf00995" "65082" "ENSG00000139719" "VPS33A" "Q547V4; Q96AX1; Q9H5Q0" "Ebola virus infection in host; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Network map of SARS-CoV-2 signaling pathway" "SARS-CoV-2 modulates autophagy" "4" "0" "0.930" "0.940" "0.884" "0.965" "0.996" "0.856" "0.931" "0.922" "0.979" "778.8" "724.3" "731.8" "688.7" "751.7" "775.4" "666.3" "724.9" "718.0" "762.7" "" "" "" "" "" "" "" "" "" "" "729.7" "599.3" "679.4" "532.4" "640.7" "740.8" "608.8" "643.6" "718.0" "734.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1998394200407490675" "False" "High" "IsMasterProtein" "Q8WUA4" "General transcription factor 3C polypeptide 2 OS=Homo sapiens OX=9606 GN=GTF3C2 PE=1 SV=2" "0.000" "False" "15.266" "7" "6" "7" "5" "911" "100.6" "7.31" "19.17" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00400" "2976" "ENSG00000115207" "GTF3C2" "D6W557; hsa:2976; Q16632; Q8WUA4; Q9BWI7" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "3" "0" "0.955" "1.012" "1.009" "0.966" "1.100" "0.965" "0.918" "1.044" "1.148" "233.5" "223.1" "236.3" "235.7" "225.7" "256.8" "225.2" "214.5" "243.8" "268.2" "" "" "" "" "" "" "" "" "" "" "218.8" "184.6" "219.4" "182.2" "192.4" "245.3" "205.8" "190.4" "243.8" "258.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3689423794866279404" "False" "High" "IsMasterProtein" "Q8N8A2" "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B OS=Homo sapiens OX=9606 GN=ANKRD44 PE=1 SV=3" "0.000" "False" "15.259" "5" "5" "8" "3" "993" "107.5" "6.30" "21.68" "5" "" "" "" "Pf12796" "91526" "ENSG00000065413" "ANKRD44" "hsa:91526; Q53SL9; Q6P480; Q86VL5; Q8IZ72; Q8N8A2; Q9UFA4" "" "" "0" "0" "0.867" "0.995" "0.992" "0.890" "0.901" "0.864" "0.899" "0.935" "1.100" "72.7" "63.0" "72.3" "72.1" "64.7" "65.5" "62.8" "65.3" "68.0" "80.0" "" "" "" "" "" "" "" "" "" "" "68.1" "52.2" "67.1" "55.8" "55.1" "62.5" "57.4" "58.0" "68.0" "77.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4655798141038654615" "False" "High" "IsMasterProtein" "Q8N6N3" "UPF0690 protein C1orf52 OS=Homo sapiens OX=9606 GN=C1orf52 PE=1 SV=1" "0.000" "False" "15.254" "30" "5" "6" "5" "182" "20.6" "5.21" "20.84" "5" "" "nucleus" "" "Pf15559" "148423" "ENSG00000162642" "C1orf52" "B3KX89; hsa:148423; Q8N6N3; Q8TDK5; Q8TDK6" "" "" "0" "0" "0.967" "0.971" "0.990" "0.981" "0.968" "1.055" "1.192" "1.083" "1.011" "402.7" "389.2" "391.2" "398.5" "395.1" "389.7" "425.0" "480.1" "436.1" "407.1" "" "" "" "" "" "" "" "" "" "" "377.3" "322.1" "363.2" "308.1" "336.8" "372.3" "388.3" "426.3" "436.1" "392.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-274346279625731140" "False" "High" "IsMasterProtein" "O00471" "Exocyst complex component 5 OS=Homo sapiens OX=9606 GN=EXOC5 PE=1 SV=1" "0.000" "False" "15.245" "7" "6" "6" "6" "708" "81.8" "6.71" "18.46" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;other cell component" "other molecular function" "Pf07393, Pf20667" "10640" "ENSG00000070367" "EXOC5" "B2R6C5; hsa:10640; O00471; Q8IW24" "Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "4" "0" "1.092" "1.011" "1.018" "1.017" "1.114" "1.013" "1.057" "1.102" "1.071" "194.2" "212.1" "196.4" "197.7" "197.4" "216.2" "196.8" "205.3" "214.0" "207.9" "" "" "" "" "" "" "" "" "" "" "181.9" "175.5" "182.3" "152.8" "168.3" "206.6" "179.8" "182.3" "214.0" "200.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6990414283188081585" "False" "High" "IsMasterProtein" "O43660" "Pleiotropic regulator 1 OS=Homo sapiens OX=9606 GN=PLRG1 PE=1 SV=1" "0.000" "False" "15.234" "11" "5" "5" "5" "514" "57.2" "9.17" "17.84" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "" "Pf00400" "5356" "ENSG00000171566" "PLRG1" "B3KMK4; hsa:5356; O43660; Q3KQY5; Q8WUD8" "" "mRNA Splicing - Major Pathway" "1" "0" "1.025" "0.977" "0.989" "1.013" "1.035" "1.107" "1.157" "1.098" "1.075" "736.3" "755.1" "719.2" "728.4" "745.9" "762.4" "815.2" "852.0" "808.4" "791.2" "" "" "" "" "" "" "" "" "" "" "689.9" "624.8" "667.7" "563.1" "635.8" "728.4" "744.9" "756.5" "808.4" "761.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6073254106150692843" "False" "High" "IsMasterProtein" "Q99575" "Ribonucleases P/MRP protein subunit POP1 OS=Homo sapiens OX=9606 GN=POP1 PE=1 SV=2" "0.000" "False" "15.227" "5" "5" "5" "5" "1024" "114.6" "9.22" "13.08" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06978, Pf08170" "10940" "ENSG00000104356" "POP1" "A8K5W9; Q15037; Q99575" "" "tRNA processing in the nucleus" "1" "0" "0.917" "0.984" "0.998" "0.941" "0.942" "0.954" "0.996" "0.993" "1.028" "409.5" "375.5" "403.1" "408.6" "385.4" "385.7" "390.7" "407.9" "406.5" "421.0" "" "" "" "" "" "" "" "" "" "" "383.7" "310.7" "374.2" "315.9" "328.5" "368.5" "357.0" "362.2" "406.5" "405.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4037115124737055274" "False" "High" "IsMasterProtein" "P04439" "HLA class I histocompatibility antigen, A alpha chain OS=Homo sapiens OX=9606 GN=HLA-A PE=1 SV=2" "0.000" "False" "15.189" "15" "5" "5" "3" "365" "40.8" "6.00" "15.91" "5" "stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00129, Pf06623, Pf07654" "3105" "ENSG00000206503" "HLA-A" "B1PKZ3; hsa:3105; O02939; O02954; O02955; O02963; O19509; O19546; O19598; O19605; O19606; O19619; O19647; O19673; O19687; O19695; O19756; O19794; O19795; O43906; O43907; O46874; O62921; O62924; O77937; O77938; O77964; O78073; O78171; O98009; O98010; O98011; O98137; P01891; P01892; P04439; P05534; P06338; P10313; P10314; P10315; P10316; P13746; P16188; P16189; P16190; P18462; P30443; P30444; P30445; P30446; P30447; P30448; P30449; P30450; P30451; P30452; P30453; P30454; P30455; P30456; P30457; P30458; P30459; P30512; P30514; P79505; P79562; P79563; Q09160; Q29680; Q29747; Q29835; Q29837; Q29838; Q29899; Q29908; Q29909; Q29910; Q30208; Q31623; Q5S3G1; Q65A82; Q8MHM1; Q8MHN9; Q95352; Q95355; Q95362; Q95377; Q95380; Q95IZ5; Q9BCN0; Q9BD15; Q9BD19; Q9GJE6; Q9GJE7; Q9GJE8; Q9MW42; Q9MY89; Q9MYA3; Q9MYA5; Q9MYC4; Q9MYE6; Q9MYE9; Q9MYG4; Q9MYG5; Q9MYI5; Q9TP25; Q9TPQ3; Q9TPR8; Q9TPX8; Q9TPX9; Q9TPY0; Q9TQ24; Q9TQE8; Q9TQE9; Q9TQF1; Q9TQF5; Q9TQF8; Q9TQF9; Q9TQG0; Q9TQG5; Q9TQG7; Q9TQH5; Q9TQI3; Q9TQK5; Q9TQM6; Q9TQN5; Q9TQP5; Q9TQP6; Q9TQP7; Q9UIN1; Q9UIN2; Q9UIP7; Q9UQU3; Q9UQU6; Q9UQU7" "Proteasome degradation; Allograft rejection; Ebola virus infection in host; Cancer immunotherapy by PD-1 blockade; TAR syndrome" "ER-Phagosome pathway; Nef mediated downregulation of MHC class I complex cell surface expression; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; E3 ubiquitin ligases ubiquitinate target proteins; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon gamma signaling; Interferon alpha/beta signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway" "14" "1" "0.968" "1.009" "0.893" "0.990" "1.101" "0.960" "1.009" "0.964" "1.011" "768.1" "743.3" "775.4" "686.0" "760.5" "845.7" "737.7" "775.1" "740.2" "776.5" "" "" "" "" "" "" "" "" "" "" "719.7" "615.1" "719.8" "530.3" "648.2" "808.0" "674.0" "688.2" "740.2" "747.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5612646896286873908" "False" "High" "IsMasterProtein" "Q6PJG2" "Mitotic deacetylase-associated SANT domain protein OS=Homo sapiens OX=9606 GN=MIDEAS PE=1 SV=2" "0.000" "False" "15.175" "6" "7" "7" "7" "1045" "114.9" "9.19" "16.98" "7" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01448" "91748" "ENSG00000156030" "MIDEAS" "hsa:91748; Q6PJG2; Q6PK13; Q6PK59; Q6ZS23" "" "" "0" "0" "1.126" "1.051" "1.153" "1.107" "1.058" "1.191" "1.135" "1.089" "1.058" "328.3" "369.8" "344.9" "378.7" "363.5" "347.2" "391.1" "372.5" "357.5" "347.5" "" "" "" "" "" "" "" "" "" "" "307.6" "306.0" "320.2" "292.7" "309.8" "331.7" "357.4" "330.8" "357.5" "334.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2662746858814386989" "False" "High" "IsMasterProtein" "Q15024" "Exosome complex component RRP42 OS=Homo sapiens OX=9606 GN=EXOSC7 PE=1 SV=3" "0.000" "False" "15.138" "20" "5" "5" "5" "291" "31.8" "5.19" "16.14" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "23016" "ENSG00000075914" "EXOSC7" "hsa:23016; Q15024; Q96E72" "Ciliary landscape" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "7" "0" "0.962" "1.023" "0.934" "0.964" "1.039" "0.974" "1.032" "0.956" "0.945" "526.4" "506.3" "538.3" "491.6" "507.4" "546.6" "512.9" "543.2" "503.3" "497.5" "" "" "" "" "" "" "" "" "" "" "493.2" "418.9" "499.7" "380.0" "432.5" "522.3" "468.6" "482.3" "503.3" "479.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6707241685728679125" "False" "High" "IsMasterProtein" "Q9NY93" "Probable ATP-dependent RNA helicase DDX56 OS=Homo sapiens OX=9606 GN=DDX56 PE=1 SV=1" "0.000" "False" "15.121" "8" "5" "7" "5" "547" "61.6" "9.26" "20.85" "5" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "54606" "ENSG00000136271" "DDX56" "A4D2K9; C9JV95; hsa:54606; Q6IAE2; Q9H9I8; Q9NY93" "" "" "0" "0" "1.037" "1.081" "1.022" "1.082" "0.982" "1.118" "1.100" "1.075" "1.076" "534.2" "554.0" "577.3" "546.0" "578.3" "524.7" "597.1" "587.4" "574.2" "574.7" "" "" "" "" "" "" "" "" "" "" "500.6" "458.5" "536.0" "422.1" "492.9" "501.3" "545.6" "521.6" "574.2" "553.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3667364436417788912" "False" "High" "IsMasterProtein" "Q9BYV8" "Centrosomal protein of 41 kDa OS=Homo sapiens OX=9606 GN=CEP41 PE=1 SV=1" "0.000" "False" "15.120" "19" "5" "5" "5" "373" "41.3" "8.32" "21.33" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "cytosol;cytoskeleton;other cell component" "" "Pf00581" "95681" "ENSG00000106477" "CEP41" "A4D1M0; B4DQ35; F5H0V6; hsa:95681; Q7Z496; Q86TM1; Q8NFU8; Q9BYV8; Q9H6A3; Q9NPV3" "Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "10" "0" "1.113" "1.028" "1.138" "1.127" "1.068" "1.070" "1.050" "1.034" "1.080" "872.6" "971.3" "897.1" "992.9" "983.1" "932.3" "933.5" "915.8" "902.6" "942.2" "" "" "" "" "" "" "" "" "" "" "817.6" "803.7" "832.9" "767.5" "838.0" "890.7" "852.9" "813.1" "902.6" "907.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2630059452900541435" "False" "High" "IsMasterProtein" "P21675" "Transcription initiation factor TFIID subunit 1 OS=Homo sapiens OX=9606 GN=TAF1 PE=1 SV=3" "0.000" "False" "15.118" "3" "7" "9" "7" "1893" "214.6" "5.06" "16.02" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00439, Pf09247, Pf12157, Pf15288" "6872" "ENSG00000147133" "TAF1" "A5CVC8; A5CVC9; A5CVD0; A5CVD1; B1Q2X3; hsa:6872; P21675; Q59FZ3; Q6IUZ1; Q70Q86; Q70Q87; Q70T00; Q70T01; Q70T02; Q70T03" "MECP2 and associated Rett syndrome" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "10" "0" "1.076" "1.085" "1.123" "1.115" "1.014" "1.061" "1.052" "1.013" "1.083" "345.9" "372.0" "375.3" "388.5" "385.7" "350.7" "367.0" "363.9" "350.2" "374.6" "" "" "" "" "" "" "" "" "" "" "324.1" "307.9" "348.4" "300.3" "328.8" "335.1" "335.3" "323.1" "350.2" "360.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1785172786280045072" "False" "High" "IsMasterProtein" "P06730" "Eukaryotic translation initiation factor 4E OS=Homo sapiens OX=9606 GN=EIF4E PE=1 SV=2" "0.000" "False" "15.094" "25" "5" "8" "5" "217" "25.1" "6.15" "28.01" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01652" "1977" "ENSG00000151247" "EIF4E" "B7Z6V1; D6RCQ6; hsa:1977; P06730; Q96E95" "Translation factors; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Interleukin-1 (IL-1) structural pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prader-Willi and Angelman syndrome; PI3K-Akt signaling pathway; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Hypertrophy model; Interferon type I signaling pathways" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "33" "0" "0.904" "1.051" "0.909" "0.961" "0.992" "0.906" "1.070" "0.997" "1.003" "955.7" "864.0" "1004.7" "869.0" "918.8" "948.2" "865.9" "1022.9" "952.5" "959.0" "" "" "" "" "" "" "" "" "" "" "895.5" "714.9" "932.7" "671.7" "783.1" "905.9" "791.2" "908.2" "952.5" "923.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3349657221176052038" "False" "High" "IsMasterProtein" "O00750" "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta OS=Homo sapiens OX=9606 GN=PIK3C2B PE=1 SV=2" "0.000" "False" "15.072" "3" "6" "6" "6" "1634" "184.7" "7.30" "15.39" "6" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00168, Pf00454, Pf00613, Pf00787, Pf00792, Pf00794" "5287" "ENSG00000133056" "PIK3C2B" "hsa:5287; O00750; O95666; Q5SW99" "Glioblastoma signaling pathways; S1P receptor signal transduction; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)" "Synthesis of PIPs at the plasma membrane" "8" "0" "0.939" "0.995" "1.102" "1.000" "1.060" "1.040" "0.926" "1.012" "0.986" "414.4" "389.0" "412.2" "456.6" "414.3" "439.4" "430.8" "383.6" "419.4" "408.5" "" "" "" "" "" "" "" "" "" "" "388.3" "321.9" "382.7" "353.0" "353.1" "419.8" "393.7" "340.6" "419.4" "393.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6326411103029325143" "False" "High" "IsMasterProtein" "P53602" "Diphosphomevalonate decarboxylase OS=Homo sapiens OX=9606 GN=MVD PE=1 SV=1" "0.000" "False" "15.072" "8" "3" "4" "3" "400" "43.4" "7.23" "16.16" "3" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00288, Pf18376" "4597" "ENSG00000167508" "MVD" "P53602; Q53Y65" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Mevalonate pathway; Aspirin and miRNAs; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis; Synthesis of Dolichyl-phosphate" "11" "0" "0.982" "0.962" "0.952" "0.955" "0.928" "0.918" "0.973" "0.959" "0.979" "734.6" "721.1" "706.4" "699.6" "701.5" "681.8" "674.4" "714.9" "704.8" "719.1" "" "" "" "" "" "" "" "" "" "" "688.3" "596.7" "655.8" "540.8" "598.0" "651.4" "616.2" "634.7" "704.8" "692.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7969393992682693722" "False" "High" "IsMasterProtein" "Q9NUJ1" "Palmitoyl-protein thioesterase ABHD10, mitochondrial OS=Homo sapiens OX=9606 GN=ABHD10 PE=1 SV=1" "0.000" "False" "15.063" "15" "4" "6" "4" "306" "33.9" "8.57" "19.63" "4" "protein metabolism;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00561" "55347" "ENSG00000144827" "ABHD10" "B7Z6A8; C9IZX5; D3DN63; hsa:55347; Q8TCF9; Q9NUJ1" "" "Glucuronidation" "1" "0" "0.969" "0.984" "1.073" "0.994" "0.946" "1.022" "1.006" "0.975" "0.958" "421.6" "408.6" "415.0" "452.6" "418.9" "398.9" "431.0" "424.1" "411.3" "404.0" "" "" "" "" "" "" "" "" "" "" "395.1" "338.1" "385.3" "349.9" "357.1" "381.1" "393.8" "376.5" "411.3" "389.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "487381900913570393" "False" "High" "IsMasterProtein" "Q9H8Y8" "Golgi reassembly-stacking protein 2 OS=Homo sapiens OX=9606 GN=GORASP2 PE=1 SV=3" "0.000" "False" "15.058" "12" "5" "6" "5" "452" "47.1" "4.82" "18.62" "5" "cell organization and biogenesis;stress response;other biological processes" "other membranes;ER/Golgi" "" "Pf04495" "26003" "ENSG00000115806" "GORASP2" "B4DKT0; hsa:26003; Q53TE3; Q96I74; Q96K84; Q9H8Y8; Q9H946; Q9UFW4" "" "Golgi Cisternae Pericentriolar Stack Reorganization" "1" "0" "1.004" "1.053" "1.184" "1.142" "0.998" "1.158" "1.056" "1.056" "1.132" "208.4" "209.2" "219.4" "246.8" "238.0" "207.9" "241.3" "219.9" "220.0" "235.8" "" "" "" "" "" "" "" "" "" "" "195.2" "173.1" "203.7" "190.8" "202.9" "198.6" "220.5" "195.3" "220.0" "227.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9168897576622990740" "False" "High" "IsMasterProtein" "O43617" "Trafficking protein particle complex subunit 3 OS=Homo sapiens OX=9606 GN=TRAPPC3 PE=1 SV=1" "0.000" "False" "15.055" "27" "5" "6" "5" "180" "20.3" "4.96" "19.23" "5" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "27095" "ENSG00000054116" "TRAPPC3" "A6NDN0; B2RDN2; D3DPS2; hsa:27095; O43617" "" "COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs" "2" "0" "0.974" "0.892" "1.135" "1.000" "0.938" "0.953" "0.964" "0.958" "0.982" "268.6" "261.6" "239.6" "304.9" "268.6" "251.9" "256.1" "258.9" "257.4" "263.9" "" "" "" "" "" "" "" "" "" "" "251.7" "216.5" "222.4" "235.7" "228.9" "240.7" "234.0" "229.9" "257.4" "254.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1688448728000248200" "False" "High" "IsMasterProtein" "Q9BZH6" "WD repeat-containing protein 11 OS=Homo sapiens OX=9606 GN=WDR11 PE=1 SV=1" "0.000" "False" "15.043" "4" "5" "6" "5" "1224" "136.6" "6.92" "15.73" "5" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "" "" "55717" "ENSG00000120008" "WDR11" "hsa:55717; Q5VWA1; Q9BZH6; Q9P2J6" "" "RHOH GTPase cycle" "1" "0" "0.934" "0.980" "0.988" "0.931" "0.967" "1.029" "0.939" "0.954" "0.989" "1184.2" "1105.8" "1160.2" "1169.7" "1102.8" "1144.6" "1218.4" "1112.4" "1130.2" "1171.6" "" "" "" "" "" "" "" "" "" "" "1109.6" "915.1" "1077.1" "904.3" "940.0" "1093.5" "1113.3" "987.7" "1130.2" "1128.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6888861531159930886" "False" "High" "IsMasterProtein" "Q9H832" "Ubiquitin-conjugating enzyme E2 Z OS=Homo sapiens OX=9606 GN=UBE2Z PE=1 SV=2" "0.000" "False" "15.042" "16" "6" "6" "6" "354" "38.2" "5.62" "15.20" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf00179" "65264" "ENSG00000159202" "UBE2Z" "A6N8M6; A6NC60; hsa:65264; Q7L354; Q8TCM4; Q9H832; Q9H893" "" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.048" "1.008" "1.085" "1.024" "1.061" "0.998" "1.049" "0.996" "1.047" "1144.7" "1199.5" "1153.3" "1242.5" "1172.6" "1214.8" "1142.8" "1201.0" "1140.6" "1198.5" "" "" "" "" "" "" "" "" "" "" "1072.6" "992.6" "1070.7" "960.5" "999.5" "1160.7" "1044.2" "1066.3" "1140.6" "1153.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7454062146017555339" "False" "High" "IsMasterProtein" "P32019" "Type II inositol 1,4,5-trisphosphate 5-phosphatase OS=Homo sapiens OX=9606 GN=INPP5B PE=1 SV=4" "0.000" "False" "15.039" "6" "6" "7" "6" "993" "112.8" "5.57" "16.84" "6" "other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00620, Pf16776, Pf21310" "3633" "ENSG00000204084" "INPP5B" "C9J6U5; hsa:3633; P32019; Q5VSG9; Q5VSH0; Q5VSH1; Q658Q5; Q6P6D4; Q6PD53; Q86YE1" "" "Synthesis of IP2, IP, and Ins in the cytosol; Synthesis of IP3 and IP4 in the cytosol" "2" "0" "0.977" "1.064" "1.020" "0.991" "0.953" "0.964" "0.969" "0.946" "1.018" "477.1" "466.3" "507.4" "486.7" "472.8" "454.7" "460.1" "462.3" "451.1" "485.5" "" "" "" "" "" "" "" "" "" "" "447.0" "385.9" "471.1" "376.2" "403.0" "434.4" "420.4" "410.5" "451.1" "467.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2633610480889665575" "False" "High" "IsMasterProtein" "O75608" "Acyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=LYPLA1 PE=1 SV=1" "0.000" "False" "15.038" "20" "5" "9" "5" "230" "24.7" "6.77" "33.16" "5" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02230" "10434" "ENSG00000120992" "LYPLA1" "hsa:10434; O43202; O75608; Q9UQF9" "" "RAS processing; eNOS activation" "2" "0" "0.963" "0.970" "0.920" "0.947" "0.980" "1.003" "0.967" "0.952" "0.945" "1367.1" "1316.9" "1326.6" "1257.3" "1294.5" "1339.1" "1370.8" "1321.3" "1301.1" "1292.2" "" "" "" "" "" "" "" "" "" "" "1280.9" "1089.7" "1231.6" "971.9" "1103.4" "1279.4" "1252.5" "1173.1" "1301.1" "1244.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3035595102958398127" "False" "High" "IsMasterProtein" "P46777" "Large ribosomal subunit protein uL18 OS=Homo sapiens OX=9606 GN=RPL5 PE=1 SV=3" "0.000" "False" "15.035" "20" "6" "7" "6" "297" "34.3" "9.72" "20.12" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf14204, Pf17144" "6125" "ENSG00000122406" "RPL5" "hsa:6125; P46777; Q32LZ3; Q53HH6; Q9H3F4" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.109" "1.067" "0.909" "0.984" "1.007" "0.978" "1.081" "1.085" "1.045" "1762.0" "1954.4" "1880.7" "1600.8" "1733.3" "1774.5" "1723.3" "1904.8" "1912.5" "1841.4" "" "" "" "" "" "" "" "" "" "" "1651.0" "1617.3" "1746.0" "1237.5" "1477.4" "1695.4" "1574.6" "1691.2" "1912.5" "1773.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2215661484008569262" "False" "High" "IsMasterProtein" "Q9UBW7" "Zinc finger MYM-type protein 2 OS=Homo sapiens OX=9606 GN=ZMYM2 PE=1 SV=1" "0.000" "False" "15.034" "4" "7" "8" "6" "1377" "154.8" "6.34" "18.67" "7" "other biological processes" "cytosol;nucleus" "other molecular function" "Pf06467, Pf12012" "7750" "ENSG00000121741" "ZMYM2" "A6NDG0; A6NI02; hsa:7750; O43212; O43434; O60898; Q5W0Q4; Q5W0T3; Q63HP0; Q8NE39; Q9H0V5; Q9H538; Q9UBW7; Q9UEU2" "" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by FLT3 fusion proteins" "3" "0" "0.954" "1.059" "1.034" "1.111" "1.088" "1.058" "1.064" "1.061" "1.082" "353.7" "337.5" "374.7" "365.8" "393.1" "384.9" "374.1" "376.4" "375.5" "382.7" "" "" "" "" "" "" "" "" "" "" "331.4" "279.3" "347.9" "282.8" "335.0" "367.7" "341.9" "334.2" "375.5" "368.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8330278091767700695" "False" "High" "IsMasterProtein" "Q6PCB5" "Lysine-specific demethylase RSBN1L OS=Homo sapiens OX=9606 GN=RSBN1L PE=1 SV=2" "0.000" "False" "15.027" "6" "5" "8" "5" "846" "94.8" "8.78" "24.96" "5" "" "nucleus" "other molecular function" "" "222194" "ENSG00000187257" "RSBN1L" "C9K0P1; hsa:222194; Q6PCB5; Q6ZS58; Q6ZVI9; Q86X48" "" "" "0" "0" "1.209" "0.970" "1.088" "1.094" "0.955" "1.062" "0.994" "1.045" "1.015" "120.2" "145.4" "116.6" "130.8" "131.5" "114.9" "127.6" "119.6" "125.7" "122.0" "" "" "" "" "" "" "" "" "" "" "112.6" "120.3" "108.3" "101.1" "112.1" "109.7" "116.6" "106.2" "125.7" "117.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4837224883862522345" "False" "High" "IsMasterProtein" "Q9BYD1" "Large ribosomal subunit protein uL13m OS=Homo sapiens OX=9606 GN=MRPL13 PE=1 SV=1" "0.000" "False" "15.021" "29" "5" "6" "5" "178" "20.7" "9.16" "23.84" "5" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00572" "28998" "ENSG00000172172" "MRPL13" "B2R4R8; hsa:28998; Q9BYD1; Q9UI04" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.040" "0.987" "1.008" "1.010" "1.036" "0.999" "0.966" "0.990" "1.013" "827.3" "860.6" "816.4" "834.1" "835.5" "857.3" "826.3" "799.0" "819.2" "838.1" "" "" "" "" "" "" "" "" "" "" "775.2" "712.1" "757.9" "644.8" "712.2" "819.0" "755.0" "709.5" "819.2" "807.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3306595998206250770" "False" "High" "IsMasterProtein" "P62753" "Small ribosomal subunit protein eS6 OS=Homo sapiens OX=9606 GN=RPS6 PE=1 SV=1" "0.000" "False" "15.015" "14" "4" "8" "4" "249" "28.7" "10.84" "25.81" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01092" "6194" "ENSG00000137154" "RPS6" "hsa:6194; P08227; P10660; P62753; Q4VBY7; Q8N6Z7" "IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; IL-2 signaling pathway; Pleural mesothelioma; 2q37 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways" "SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; Protein hydroxylation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nuclear events stimulated by ALK signaling in cancer; SARS-CoV-1 modulates host translation machinery" "49" "0" "0.928" "1.027" "0.915" "1.034" "1.060" "1.125" "1.226" "1.082" "1.068" "957.0" "887.7" "982.7" "875.6" "989.7" "1014.9" "1076.7" "1172.9" "1035.2" "1022.3" "" "" "" "" "" "" "" "" "" "" "896.7" "734.6" "912.4" "676.8" "843.6" "969.6" "983.8" "1041.4" "1035.2" "984.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-299196629688227683" "False" "High" "IsMasterProtein" "Q9UGM6" "Tryptophan--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=WARS2 PE=1 SV=1" "0.000" "False" "15.014" "14" "5" "6" "5" "360" "40.1" "9.28" "17.92" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;nucleus" "other molecular function" "Pf00579" "10352" "ENSG00000116874" "WARS2" "B1ALR1; B2R9D4; hsa:10352; Q53FT4; Q5VUD2; Q86TQ0; Q9UGM6" "" "Mitochondrial tRNA aminoacylation" "1" "0" "0.971" "1.100" "1.138" "1.145" "1.136" "1.049" "1.044" "1.134" "1.051" "274.2" "266.1" "301.6" "312.0" "314.0" "311.5" "287.5" "286.3" "311.0" "288.3" "" "" "" "" "" "" "" "" "" "" "256.9" "220.2" "280.0" "241.2" "267.7" "297.6" "262.7" "254.2" "311.0" "277.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6054246856873050357" "False" "High" "IsMasterProtein" "Q15118" "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial OS=Homo sapiens OX=9606 GN=PDK1 PE=1 SV=1" "0.000" "False" "14.985" "12" "5" "5" "5" "436" "49.2" "8.81" "15.93" "5" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "mitochondrion" "kinase activity;other molecular function" "Pf02518, Pf10436" "5163" "ENSG00000152256" "PDK1" "B2R6T1; B7Z937; D3DPD8; E9PD65; hsa:5163; Q15118; Q308M4" "T cell receptor and co-stimulatory signaling; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Hereditary leiomyomatosis and renal cell carcinoma pathway; Non-small cell lung cancer; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Aspirin and miRNAs; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; TCA cycle in senescence; Pleural mesothelioma; Orexin receptor pathway; Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution; Glucose metabolism in triple-negative breast cancer cells; GNAQ pathways in port-wine stain; EPO receptor signaling; DNA damage response (only ATM dependent)" "Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "23" "0" "1.149" "1.052" "1.080" "1.069" "1.057" "0.956" "0.923" "0.929" "1.068" "359.0" "412.5" "377.6" "387.9" "383.8" "379.4" "343.2" "331.3" "333.5" "383.3" "" "" "" "" "" "" "" "" "" "" "336.4" "341.3" "350.6" "299.8" "327.1" "362.5" "313.6" "294.1" "333.5" "369.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3075207303668690710" "False" "High" "IsMasterProtein" "P37198" "Nuclear pore glycoprotein p62 OS=Homo sapiens OX=9606 GN=NUP62 PE=1 SV=3" "0.000" "False" "14.984" "7" "3" "5" "3" "522" "53.2" "5.31" "18.67" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05064" "23636" "ENSG00000213024" "NUP62" "B3KWU5; hsa:23636; P37198; Q503A4; Q6GTM2; Q96C43; Q9NSL1" "7q11.23 copy number variation syndrome" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Early Events; Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "30" "0" "0.987" "0.963" "1.108" "1.105" "1.215" "0.997" "1.130" "1.059" "1.059" "636.4" "627.9" "612.6" "705.2" "702.9" "773.1" "634.5" "719.0" "673.8" "674.0" "" "" "" "" "" "" "" "" "" "" "596.3" "519.6" "568.7" "545.2" "599.1" "738.6" "579.8" "638.4" "673.8" "649.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4893836570063627970" "False" "High" "IsMasterProtein" "O75494" "Serine/arginine-rich splicing factor 10 OS=Homo sapiens OX=9606 GN=SRSF10 PE=1 SV=1" "0.000" "False" "14.966" "20" "5" "5" "5" "262" "31.3" "11.27" "18.50" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "10772" "ENSG00000188529" "SRSF10" "A6NFM6; A6NI42; A6NIU7; B4DJP9; hsa:10772; O60572; O75494; Q5JRH9; Q5JRI0; Q5JRI2; Q5JRI3; Q5JRI4; Q96G09; Q96P17" "mRNA processing" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "3" "0" "1.032" "1.186" "1.160" "0.971" "1.065" "1.194" "0.914" "1.013" "1.081" "115.0" "118.7" "136.4" "133.4" "111.7" "122.5" "137.3" "105.1" "116.5" "124.4" "" "" "" "" "" "" "" "" "" "" "107.7" "98.2" "126.6" "103.1" "95.2" "117.0" "125.4" "93.4" "116.5" "119.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4039607230823659526" "False" "High" "IsMasterProtein" "P42025" "Beta-centractin OS=Homo sapiens OX=9606 GN=ACTR1B PE=1 SV=1" "0.000" "False" "14.947" "14" "5" "7" "2" "376" "42.3" "6.40" "21.78" "5" "" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00022" "10120" "ENSG00000115073; ENSG00000291597" "ACTR1B" "D3DVH2; hsa:10120; P42025; Q53SK5; Q9BRB7" "" "Neutrophil degranulation; MHC class II antigen presentation" "2" "0" "0.913" "0.964" "0.907" "0.950" "0.973" "0.961" "0.958" "0.839" "0.935" "641.1" "585.4" "618.1" "581.7" "609.3" "623.7" "615.8" "614.3" "537.6" "599.4" "" "" "" "" "" "" "" "" "" "" "600.7" "484.4" "573.8" "449.7" "519.3" "595.9" "562.7" "545.5" "537.6" "577.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7680692845404357414" "False" "High" "IsMasterProtein" "P30085" "UMP-CMP kinase OS=Homo sapiens OX=9606 GN=CMPK1 PE=1 SV=3" "0.000" "False" "14.944" "29" "5" "11" "5" "196" "22.2" "5.57" "37.23" "5" "other metabolic processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00406" "51727" "ENSG00000162368" "CMPK1" "B2R6S5; B4DPU7; E9PGI8; hsa:51727; P30085; Q53GB7; Q5SVZ0; Q96C07; Q9UBQ8; Q9UIA2" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "1.103" "1.016" "1.064" "1.026" "1.086" "0.960" "1.038" "1.187" "1.098" "1239.5" "1367.7" "1258.8" "1318.9" "1271.8" "1346.2" "1189.8" "1286.3" "1471.7" "1361.1" "" "" "" "" "" "" "" "" "" "" "1161.4" "1131.8" "1168.6" "1019.6" "1084.0" "1286.2" "1087.2" "1142.1" "1471.7" "1310.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6495840506053035661" "False" "High" "IsMasterProtein" "Q9NRV9" "Heme-binding protein 1 OS=Homo sapiens OX=9606 GN=HEBP1 PE=1 SV=1" "0.000" "False" "14.926" "23" "4" "5" "4" "189" "21.1" "5.80" "21.81" "4" "other biological processes" "non-structural extracellular;other cell component" "other molecular function" "Pf04832" "50865" "ENSG00000013583" "HEBP1" "A8K1G2; hsa:50865; Q9NRV9; Q9Y5Z5" "" "G alpha (i) signalling events; Formyl peptide receptors bind formyl peptides and many other ligands" "2" "0" "1.078" "1.002" "1.010" "1.049" "1.081" "0.968" "1.013" "1.088" "1.049" "982.8" "1059.5" "984.5" "993.0" "1031.4" "1062.3" "951.1" "995.8" "1069.2" "1031.0" "" "" "" "" "" "" "" "" "" "" "920.9" "876.7" "914.0" "767.6" "879.1" "1014.9" "869.1" "884.1" "1069.2" "992.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "217416082876923675" "False" "High" "IsMasterProtein" "O75410" "Transforming acidic coiled-coil-containing protein 1 OS=Homo sapiens OX=9606 GN=TACC1 PE=1 SV=2" "0.000" "False" "14.923" "6" "5" "7" "5" "805" "87.7" "4.88" "21.30" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05010" "6867" "ENSG00000147526" "TACC1" "B2RBD9; B4E302; D3DSX6; hsa:6867; O75410; Q6Y687; Q86YG7; Q8IUJ2; Q8IUJ3; Q8IUJ4; Q8IZG2; Q8NEY7; Q9UPP9" "" "" "0" "0" "1.004" "1.056" "1.132" "1.124" "1.108" "1.168" "1.205" "1.165" "1.128" "445.7" "447.3" "470.6" "504.4" "501.0" "493.7" "520.6" "537.2" "519.1" "502.8" "" "" "" "" "" "" "" "" "" "" "417.6" "370.2" "436.9" "389.9" "427.1" "471.7" "475.7" "477.0" "519.1" "484.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1887782222287180929" "False" "High" "IsMasterProtein" "Q9ULV4" "Coronin-1C OS=Homo sapiens OX=9606 GN=CORO1C PE=1 SV=1" "0.000" "False" "14.914" "12" "6" "6" "6" "474" "53.2" "7.08" "19.02" "6" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf16300" "23603" "ENSG00000110880" "CORO1C" "A7MAP0; A7MAP1; B3KU12; hsa:23603; Q9NSK5; Q9ULV4" "" "" "0" "0" "0.946" "1.110" "0.995" "1.074" "1.034" "1.075" "1.145" "1.033" "1.029" "476.8" "450.9" "529.3" "474.6" "512.0" "492.9" "512.7" "545.9" "492.4" "490.4" "" "" "" "" "" "" "" "" "" "" "446.7" "373.1" "491.4" "366.9" "436.4" "471.0" "468.4" "484.7" "492.4" "472.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6827069170954705052" "False" "High" "IsMasterProtein" "Q9UKJ3" "G patch domain-containing protein 8 OS=Homo sapiens OX=9606 GN=GPATCH8 PE=1 SV=2" "0.000" "False" "14.902" "4" "5" "5" "5" "1502" "164.1" "8.66" "12.84" "5" "" "nucleus" "other molecular function" "Pf01585" "23131" "ENSG00000186566" "GPATCH8" "B9EGP9; hsa:23131; O60300; Q8TB99; Q9UKJ3" "" "" "0" "0" "0.982" "1.029" "0.977" "1.059" "1.034" "0.982" "0.998" "0.954" "1.034" "439.5" "431.6" "452.1" "429.4" "465.5" "454.4" "431.8" "438.5" "419.2" "454.5" "" "" "" "" "" "" "" "" "" "" "411.9" "357.1" "419.7" "331.9" "396.8" "434.1" "394.5" "389.4" "419.2" "437.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3387602003086690885" "False" "High" "IsMasterProtein" "Q9BVC5" "Ashwin OS=Homo sapiens OX=9606 GN=C2orf49 PE=1 SV=1" "0.000" "False" "14.900" "31" "5" "6" "5" "232" "25.8" "9.74" "15.40" "5" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus;other cell component" "" "Pf15323" "79074" "ENSG00000135974" "C2orf49" "B3KXN3; B4E2G9; hsa:79074; Q9BVC5" "" "tRNA processing in the nucleus" "1" "0" "1.162" "0.973" "1.093" "1.024" "1.054" "0.763" "0.789" "0.799" "0.988" "368.1" "427.8" "358.2" "402.5" "377.0" "388.1" "280.8" "290.5" "294.1" "363.6" "" "" "" "" "" "" "" "" "" "" "344.9" "354.0" "332.6" "311.1" "321.4" "370.8" "256.6" "257.9" "294.1" "350.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4844902181037291409" "False" "High" "IsMasterProtein" "P62314" "Small nuclear ribonucleoprotein Sm D1 OS=Homo sapiens OX=9606 GN=SNRPD1 PE=1 SV=1" "0.000" "False" "14.891" "28" "3" "6" "3" "119" "13.3" "11.56" "27.11" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6632" "ENSG00000167088" "SNRPD1" "B5BTZ1; hsa:6632; P13641; P62314" "mRNA processing" "mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; snRNP Assembly; mRNA Splicing - Minor Pathway" "5" "0" "0.902" "0.894" "0.961" "0.899" "0.800" "0.975" "0.966" "0.946" "0.903" "319.6" "288.2" "285.7" "307.0" "287.5" "255.6" "311.6" "308.7" "302.3" "288.5" "" "" "" "" "" "" "" "" "" "" "299.5" "238.5" "265.2" "237.3" "245.0" "244.2" "284.7" "274.1" "302.3" "277.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4299442073717893558" "False" "High" "IsMasterProtein" "Q9Y6A4" "Cilia- and flagella-associated protein 20 OS=Homo sapiens OX=9606 GN=CFAP20 PE=1 SV=1" "0.000" "False" "14.888" "21" "4" "6" "4" "193" "22.8" "9.76" "18.18" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf05018" "29105" "ENSG00000070761" "CFAP20" "hsa:29105; Q9Y6A4" "" "" "0" "0" "1.147" "1.087" "0.932" "1.021" "1.174" "1.040" "1.043" "1.252" "1.099" "564.9" "647.7" "613.7" "526.7" "576.5" "663.3" "587.5" "589.2" "707.0" "620.5" "" "" "" "" "" "" "" "" "" "" "529.3" "535.9" "569.8" "407.2" "491.4" "633.7" "536.8" "523.1" "707.0" "597.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8197939441703168183" "False" "High" "IsMasterProtein" "Cont_P12763" "Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2" "0.000" "True" "14.884" "10" "4" "6" "4" "359" "38.4" "5.50" "18.77" "4" "stress response;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00031" "280988" "ENSBTAG00000000522" "AHSG" "A6QLF7; B0JYN6; bta:280988; P12763" "" "Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "4" "0" "1.069" "0.905" "1.209" "1.353" "1.308" "1.338" "1.218" "1.428" "1.189" "546.3" "584.1" "494.1" "660.2" "739.2" "714.5" "731.1" "665.6" "779.8" "649.2" "" "" "" "" "" "" "" "" "" "" "511.8" "483.3" "458.7" "510.4" "630.0" "682.6" "668.1" "591.0" "779.8" "625.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5039007955841066877" "False" "High" "IsMasterProtein" "Q15397" "Pumilio homolog 3 OS=Homo sapiens OX=9606 GN=PUM3 PE=1 SV=3" "0.000" "False" "14.870" "8" "6" "8" "6" "648" "73.5" "9.64" "22.70" "6" "other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf08144" "9933" "ENSG00000080608" "PUM3" "A8K804; hsa:9933; Q15397; Q547G7; Q5SZY9; Q6IB47; Q96B27; Q96L78; Q96L79; Q96L80" "" "" "0" "0" "1.011" "0.997" "1.198" "1.387" "1.136" "1.238" "1.204" "1.337" "1.125" "89.7" "90.7" "89.4" "107.4" "124.5" "101.9" "111.1" "108.1" "119.9" "100.9" "" "" "" "" "" "" "" "" "" "" "84.1" "75.1" "83.0" "83.1" "106.1" "97.3" "101.5" "95.9" "119.9" "97.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1594484432885072185" "False" "High" "IsMasterProtein" "O75663" "TIP41-like protein OS=Homo sapiens OX=9606 GN=TIPRL PE=1 SV=2" "0.000" "False" "14.853" "15" "5" "6" "5" "272" "31.4" "5.91" "15.49" "5" "stress response;signal transduction;other biological processes" "cytosol" "" "Pf04176" "261726" "ENSG00000143155" "TIPRL" "B2R8V3; hsa:261726; O75663; Q5HYB2; Q8IZ86" "Ciliary landscape" "" "1" "0" "0.915" "0.957" "0.956" "0.971" "0.923" "0.863" "0.947" "0.953" "0.971" "499.3" "456.8" "478.0" "477.2" "485.0" "461.0" "430.9" "472.9" "475.9" "484.7" "" "" "" "" "" "" "" "" "" "" "467.8" "378.0" "443.8" "368.9" "413.4" "440.4" "393.7" "419.9" "475.9" "466.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5762449723745155897" "False" "High" "IsMasterProtein" "Q9H5V9" "STING ER exit protein OS=Homo sapiens OX=9606 GN=STEEP1 PE=1 SV=1" "0.000" "False" "14.836" "18" "5" "6" "5" "222" "25.6" "8.73" "18.73" "5" "cell organization and biogenesis;transport" "cytoskeleton;nucleus;other cell component" "" "" "63932" "ENSG00000018610" "STEEP1" "A8MPX7; B4DQN2; D3DWH9; F5GWL7; hsa:63932; O43351; Q9H5V9" "" "mRNA Splicing - Major Pathway" "1" "0" "1.044" "0.982" "0.993" "1.020" "1.068" "1.093" "1.243" "1.210" "1.116" "822.4" "858.9" "807.6" "816.5" "838.9" "878.7" "898.8" "1022.6" "994.9" "917.9" "" "" "" "" "" "" "" "" "" "" "770.6" "710.7" "749.7" "631.2" "715.0" "839.5" "821.3" "908.0" "994.9" "883.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3539568279205584801" "False" "High" "IsMasterProtein" "P57764" "Gasdermin-D OS=Homo sapiens OX=9606 GN=GSDMD PE=1 SV=1" "0.000" "False" "14.804" "11" "5" "9" "5" "484" "52.8" "5.08" "24.31" "5" "cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "transporter activity;other molecular function" "Pf04598, Pf17708" "79792" "ENSG00000104518; ENSG00000278718" "GSDMD" "A8K702; D3DWJ9; hsa:79792; P57764; Q96Q98" "STING pathway in Kawasaki-like disease and COVID-19" "Purinergic signaling in leishmaniasis infection; Neutrophil degranulation; Regulation of TLR by endogenous ligand; Release of apoptotic factors from the mitochondria; Pyroptosis; Interleukin-1 processing" "7" "0" "0.944" "1.023" "1.007" "1.007" "1.015" "0.953" "0.932" "0.917" "0.959" "822.3" "776.7" "841.4" "827.9" "828.3" "834.3" "783.5" "766.5" "754.4" "788.6" "" "" "" "" "" "" "" "" "" "" "770.5" "642.7" "781.1" "640.0" "706.0" "797.1" "715.9" "680.5" "754.4" "759.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1575206036117319314" "False" "High" "IsMasterProtein" "Q9Y608" "Leucine-rich repeat flightless-interacting protein 2 OS=Homo sapiens OX=9606 GN=LRRFIP2 PE=1 SV=1" "0.000" "False" "14.780" "5" "3" "4" "2" "721" "82.1" "6.95" "16.43" "3" "cell-cell signaling;signal transduction;other biological processes" "" "other molecular function" "Pf09738" "9209" "ENSG00000093167" "LRRFIP2" "A8K649; A8MXR0; B4DY63; Q68CV3; Q9NXH5; Q9Y608" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.079" "1.025" "1.122" "1.078" "1.087" "1.081" "1.101" "1.115" "1.104" "419.8" "453.0" "430.3" "471.1" "452.8" "456.5" "454.0" "462.3" "468.2" "463.4" "" "" "" "" "" "" "" "" "" "" "393.4" "374.8" "399.5" "364.2" "385.9" "436.2" "414.9" "410.4" "468.2" "446.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3321226471008760" "False" "High" "IsMasterProtein" "Q9Y2Q3" "Glutathione S-transferase kappa 1 OS=Homo sapiens OX=9606 GN=GSTK1 PE=1 SV=3" "0.000" "False" "14.777" "23" "4" "4" "4" "226" "25.5" "8.41" "15.62" "4" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf01323" "373156" "ENSG00000197448" "GSTK1" "B4DIH1; B4DSY2; hsa:373156; Q6P4H0; Q7Z520; Q9P1S4; Q9Y2Q3" "Metapathway biotransformation Phase I and II" "Peroxisomal protein import; Glutathione conjugation" "3" "0" "1.042" "1.084" "1.052" "1.080" "1.141" "1.068" "1.035" "0.989" "1.009" "576.4" "600.5" "625.1" "606.7" "622.8" "657.5" "615.8" "596.8" "569.8" "581.5" "" "" "" "" "" "" "" "" "" "" "540.1" "496.9" "580.3" "469.0" "530.9" "628.2" "562.6" "529.9" "569.8" "559.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1220366376593556815" "False" "High" "IsMasterProtein" "Q9Y5U2" "U5 small nuclear ribonucleoprotein TSSC4 OS=Homo sapiens OX=9606 GN=TSSC4 PE=1 SV=3" "0.000" "False" "14.769" "15" "5" "8" "5" "329" "34.3" "5.19" "23.35" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf15264" "10078" "ENSG00000184281" "TSSC4" "C9JS66; hsa:10078; Q86VL2; Q9BRS6; Q9Y5U2" "" "" "0" "0" "0.935" "1.013" "1.060" "0.984" "0.971" "1.058" "0.999" "0.933" "1.027" "1107.3" "1035.4" "1121.4" "1173.7" "1089.6" "1075.6" "1171.0" "1106.4" "1033.4" "1136.8" "" "" "" "" "" "" "" "" "" "" "1037.5" "856.8" "1041.1" "907.4" "928.7" "1027.7" "1070.0" "982.4" "1033.4" "1094.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6665492664209257681" "False" "High" "IsMasterProtein" "Q6P1Q9" "tRNA N(3)-methylcytidine methyltransferase METTL2B OS=Homo sapiens OX=9606 GN=METTL2B PE=1 SV=3" "0.000" "False" "14.758" "13" "5" "8" "5" "378" "43.4" "5.86" "24.36" "5" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf08242" "55798" "ENSG00000165055" "METTL2B" "B4DZ68; hsa:55798; Q0IJ54; Q3B7J1; Q6P1Q9" "" "" "0" "0" "1.063" "0.998" "1.104" "1.067" "1.016" "0.997" "1.045" "0.967" "1.038" "772.8" "821.2" "771.5" "852.9" "824.7" "784.8" "770.7" "807.7" "747.4" "802.0" "" "" "" "" "" "" "" "" "" "" "724.1" "679.5" "716.2" "659.3" "703.0" "749.8" "704.3" "717.2" "747.4" "772.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6736379060781022662" "False" "High" "IsMasterProtein" "P21399" "Cytoplasmic aconitate hydratase OS=Homo sapiens OX=9606 GN=ACO1 PE=1 SV=3" "0.000" "False" "14.751" "5" "5" "5" "5" "889" "98.3" "6.68" "16.31" "5" "other metabolic processes;transport;developmental processes;other biological processes" "cytosol;mitochondrion;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00330, Pf00694" "48" "ENSG00000122729" "ACO1" "D3DRK7; hsa:48; P21399; Q14652; Q5VZA7" "Iron metabolism in placenta; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc)" "Iron uptake and transport" "3" "0" "1.075" "0.966" "1.376" "1.068" "1.018" "1.217" "1.044" "0.963" "1.064" "388.9" "417.9" "375.5" "535.0" "415.5" "395.9" "473.1" "406.0" "374.3" "413.6" "" "" "" "" "" "" "" "" "" "" "364.4" "345.8" "348.6" "413.6" "354.1" "378.3" "432.3" "360.5" "374.3" "398.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3928558694847449526" "False" "High" "IsMasterProtein" "Q9UBQ5" "Eukaryotic translation initiation factor 3 subunit K OS=Homo sapiens OX=9606 GN=EIF3K PE=1 SV=1" "0.000" "False" "14.750" "21" "4" "7" "4" "218" "25.0" "4.93" "22.40" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf10075" "27335" "ENSG00000178982; ENSG00000282986" "EIF3K" "A8K0I9; B7ZAM9; hsa:27335; Q96IQ0; Q9UBQ5; Q9Y6D1" "" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "6" "0" "1.172" "0.989" "0.986" "0.970" "0.903" "1.140" "1.064" "1.132" "0.990" "210.7" "246.9" "208.4" "207.8" "204.4" "190.2" "240.2" "224.1" "238.4" "208.6" "" "" "" "" "" "" "" "" "" "" "197.4" "204.3" "193.5" "160.6" "174.2" "181.7" "219.5" "199.0" "238.4" "200.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6714438533049162384" "False" "High" "IsMasterProtein" "O94953" "Lysine-specific demethylase 4B OS=Homo sapiens OX=9606 GN=KDM4B PE=1 SV=4" "0.000" "False" "14.743" "6" "6" "7" "6" "1096" "121.8" "7.09" "19.21" "6" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02373, Pf02375, Pf13831, Pf13832, Pf18104" "23030" "ENSG00000127663" "KDM4B" "B9EGN8; D6W631; hsa:23030; O75274; O94953; Q6P3R5; Q9P1V1; Q9UF40" "" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Estrogen-dependent gene expression; HDMs demethylate histones" "3" "0" "0.950" "0.941" "1.015" "1.024" "0.951" "0.949" "0.952" "0.868" "0.967" "607.3" "576.8" "571.8" "616.4" "621.7" "577.5" "576.1" "578.0" "527.3" "587.2" "" "" "" "" "" "" "" "" "" "" "569.1" "477.3" "530.8" "476.5" "529.9" "551.8" "526.4" "513.2" "527.3" "565.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-699838257049576232" "False" "High" "IsMasterProtein" "Q8IWC1" "MAP7 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=MAP7D3 PE=1 SV=2" "0.000" "False" "14.735" "5" "5" "6" "5" "876" "98.4" "9.32" "17.59" "5" "cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf05672" "79649" "ENSG00000129680" "MAP7D3" "A2A2J0; A6NCZ7; A6NHR4; B4DWD2; H7BY77; hsa:79649; Q5JXI5; Q5JXI6; Q6P2S1; Q8IWC1; Q9H9M8" "" "" "0" "0" "1.043" "1.052" "1.144" "1.085" "1.046" "1.110" "1.091" "1.106" "1.073" "286.2" "298.5" "301.1" "327.5" "310.7" "299.4" "317.7" "312.3" "316.5" "307.2" "" "" "" "" "" "" "" "" "" "" "268.2" "247.0" "279.5" "253.2" "264.8" "286.1" "290.3" "277.3" "316.5" "295.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4915588766185396896" "False" "High" "IsMasterProtein" "Q86U44" "N6-adenosine-methyltransferase catalytic subunit OS=Homo sapiens OX=9606 GN=METTL3 PE=1 SV=2" "0.000" "False" "14.723" "9" "6" "6" "6" "580" "64.4" "6.42" "14.85" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05063" "56339" "ENSG00000165819" "METTL3" "hsa:56339; O14736; Q86U44; Q86V05; Q9HB32" "mRNA processing" "Processing of Capped Intron-Containing Pre-mRNA" "2" "0" "1.071" "0.978" "1.092" "1.121" "1.036" "1.147" "1.037" "1.081" "1.098" "195.2" "209.0" "190.9" "213.1" "218.7" "202.3" "223.8" "202.4" "211.0" "214.2" "" "" "" "" "" "" "" "" "" "" "182.9" "172.9" "177.2" "164.7" "186.4" "193.2" "204.5" "179.8" "211.0" "206.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3245672403803654152" "False" "High" "IsMasterProtein" "P62263" "Small ribosomal subunit protein uS11 OS=Homo sapiens OX=9606 GN=RPS14 PE=1 SV=3" "0.000" "False" "14.714" "28" "4" "4" "4" "151" "16.3" "10.05" "18.03" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00411" "6208" "ENSG00000164587" "RPS14" "B2R5G5; D3DQG5; hsa:6208; P06366; P62263; Q5BJI0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "20" "0" "1.108" "1.052" "1.052" "1.110" "1.142" "1.179" "1.167" "1.181" "1.111" "516.6" "572.5" "543.2" "543.2" "573.4" "590.0" "609.1" "602.8" "610.0" "573.8" "" "" "" "" "" "" "" "" "" "" "484.0" "473.7" "504.3" "419.9" "488.8" "563.7" "556.6" "535.2" "610.0" "552.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5987314834012537405" "False" "High" "IsMasterProtein" "O60888" "Protein CutA OS=Homo sapiens OX=9606 GN=CUTA PE=1 SV=2" "0.000" "False" "14.704" "22" "3" "6" "3" "179" "19.1" "5.50" "23.39" "3" "other biological processes" "other membranes" "other molecular function" "Pf03091" "51596" "ENSG00000112514; ENSG00000226492" "CUTA" "A2AB26; A2BEL4; hsa:51596; O60888; Q3B784; Q5JXM9; Q5SU05; Q9NYQ9" "" "" "0" "0" "1.133" "1.038" "1.104" "1.074" "1.078" "1.110" "1.087" "1.022" "1.021" "500.9" "567.7" "520.0" "553.0" "538.1" "540.0" "556.2" "544.6" "511.8" "511.5" "" "" "" "" "" "" "" "" "" "" "469.3" "469.7" "482.7" "427.5" "458.6" "515.9" "508.3" "483.6" "511.8" "492.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5381217781487520932" "False" "High" "IsMasterProtein" "Q99536" "Synaptic vesicle membrane protein VAT-1 homolog OS=Homo sapiens OX=9606 GN=VAT1 PE=1 SV=2" "0.000" "False" "14.702" "15" "4" "9" "4" "393" "41.9" "6.29" "29.15" "4" "other biological processes" "non-structural extracellular;other membranes;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf08240, Pf13602" "10493" "ENSG00000108828" "VAT1" "A8K345; B0AZP7; B4DPX4; hsa:10493; Q13035; Q5BKZ7; Q96A39; Q99536; Q9BUT8" "" "Neutrophil degranulation" "1" "0" "0.988" "1.007" "1.024" "1.039" "0.982" "0.984" "0.990" "0.964" "1.007" "891.7" "880.9" "897.8" "912.9" "926.5" "875.7" "877.5" "882.8" "859.5" "898.1" "" "" "" "" "" "" "" "" "" "" "835.5" "729.0" "833.5" "705.7" "789.7" "836.7" "801.8" "783.8" "859.5" "864.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4021992825547666354" "False" "High" "IsMasterProtein" "Q8TDB6" "E3 ubiquitin-protein ligase DTX3L OS=Homo sapiens OX=9606 GN=DTX3L PE=1 SV=1" "0.000" "False" "14.699" "8" "5" "5" "5" "740" "83.5" "8.06" "16.91" "5" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf13923, Pf18102, Pf21717, Pf21718" "151636" "ENSG00000163840" "DTX3L" "B3KWH6; Q53ZZ3; Q5MJP7; Q8TDB6" "Notch signaling" "Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.021" "1.055" "1.041" "1.053" "1.046" "0.940" "0.965" "1.008" "1.070" "1102.7" "1126.3" "1163.8" "1147.5" "1161.2" "1153.5" "1036.2" "1064.4" "1111.6" "1180.1" "" "" "" "" "" "" "" "" "" "" "1033.3" "932.0" "1080.5" "887.1" "989.8" "1102.1" "946.8" "945.1" "1111.6" "1136.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3197858597980699967" "False" "High" "IsMasterProtein" "Q9HA64" "Ketosamine-3-kinase OS=Homo sapiens OX=9606 GN=FN3KRP PE=1 SV=2" "0.000" "False" "14.678" "18" "5" "5" "5" "309" "34.4" "7.33" "17.14" "5" "protein metabolism;other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf03881" "79672" "ENSG00000141560" "FN3KRP" "hsa:79672; Q969F4; Q9H0U7; Q9HA64" "" "Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation" "1" "0" "1.039" "0.958" "0.996" "0.982" "0.971" "0.964" "0.979" "0.992" "0.949" "559.5" "581.1" "535.9" "557.4" "549.2" "543.3" "539.5" "547.8" "554.9" "530.7" "" "" "" "" "" "" "" "" "" "" "524.2" "480.8" "497.5" "430.9" "468.1" "519.0" "493.0" "486.4" "554.9" "511.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1736163179168070894" "False" "High" "IsMasterProtein" "Q9Y2V7" "Conserved oligomeric Golgi complex subunit 6 OS=Homo sapiens OX=9606 GN=COG6 PE=1 SV=2" "0.000" "False" "14.666" "7" "5" "7" "5" "657" "73.2" "5.76" "20.68" "5" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi" "" "Pf06419, Pf20653" "57511" "ENSG00000133103" "COG6" "hsa:57511; Q5T0U1; Q6AI19; Q86V49; Q9ULT5; Q9Y2V7" "" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "3" "0" "0.942" "0.941" "0.965" "0.997" "1.073" "1.029" "0.970" "0.991" "1.058" "535.4" "504.6" "504.0" "516.5" "533.7" "574.8" "551.1" "519.4" "530.8" "566.3" "" "" "" "" "" "" "" "" "" "" "501.7" "417.5" "467.9" "399.3" "454.9" "549.1" "503.6" "461.2" "530.8" "545.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3276103228213200498" "False" "High" "IsMasterProtein" "P62308" "Small nuclear ribonucleoprotein G OS=Homo sapiens OX=9606 GN=SNRPG PE=1 SV=1" "0.000" "False" "14.637" "34" "3" "10" "3" "76" "8.5" "8.88" "22.86" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6637" "ENSG00000143977" "SNRPG" "D6W5G6; hsa:6637; P62308; Q15357; Q6IB86" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; RNA Polymerase II Transcription Termination; snRNP Assembly; SARS-CoV-2 modulates host translation machinery; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "1.055" "1.040" "1.157" "1.015" "1.070" "1.113" "1.106" "1.131" "1.085" "902.9" "952.6" "938.8" "1045.0" "916.5" "965.9" "1005.4" "998.2" "1020.9" "979.6" "" "" "" "" "" "" "" "" "" "" "846.0" "788.3" "871.5" "807.8" "781.2" "922.8" "918.6" "886.3" "1020.9" "943.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5631999146533429965" "False" "High" "IsMasterProtein" "Q02878" "Large ribosomal subunit protein eL6 OS=Homo sapiens OX=9606 GN=RPL6 PE=1 SV=3" "0.000" "False" "14.620" "17" "6" "9" "6" "288" "32.7" "10.58" "27.04" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01159, Pf03868" "6128" "ENSG00000089009" "RPL6" "hsa:6128; Q02878; Q2M3Q3; Q8WW97" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.977" "0.944" "0.892" "0.928" "0.958" "0.988" "0.933" "0.827" "0.905" "349.7" "341.7" "330.3" "312.0" "324.4" "335.1" "345.5" "326.3" "289.1" "316.4" "" "" "" "" "" "" "" "" "" "" "327.6" "282.8" "306.6" "241.2" "276.5" "320.1" "315.7" "289.8" "289.1" "304.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1654443810418690353" "False" "High" "IsMasterProtein" "Q9UJU2" "Lymphoid enhancer-binding factor 1 OS=Homo sapiens OX=9606 GN=LEF1 PE=1 SV=1" "0.000" "False" "14.613" "14" "5" "8" "5" "399" "44.2" "7.42" "24.10" "5" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf08347" "51176" "ENSG00000138795" "LEF1" "B4DG38; B7Z8E2; E9PDK3; hsa:51176; Q3ZCU4; Q9HAZ0; Q9UJU2" "Arrhythmogenic right ventricular cardiomyopathy; Endoderm differentiation; Mesodermal commitment pathway; Mesodermal commitment pathway; Wnt signaling pathway; Hepatitis C and hepatocellular carcinoma; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Amplification and expansion of oncogenic pathways as metastatic traits; Canonical and non-canonical Notch signaling; Wnt signaling pathway and pluripotency; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; Effect of progerin on genes involved in progeria; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Hippo signaling regulation pathways; TGF-beta receptor signaling in skeletal dysplasias; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Acute myeloid leukemia; 11p11.2 copy number variation syndrome ; Cell lineage map for neuronal differentiation; TGF-beta receptor signaling; DNA damage response (only ATM dependent)" "Formation of paraxial mesoderm; Ca2+ pathway; Somitogenesis; Formation of axial mesoderm; Deactivation of the beta-catenin transactivating complex; Transcriptional Regulation by VENTX; Cardiogenesis; Germ layer formation at gastrulation; Transcriptional regulation of granulopoiesis; Binding of TCF/LEF:CTNNB1 to target gene promoters; RUNX3 regulates WNT signaling; Repression of WNT target genes" "41" "0" "1.025" "1.023" "0.996" "1.062" "0.981" "0.892" "0.939" "0.949" "0.984" "511.2" "524.0" "522.8" "509.3" "542.8" "501.7" "456.1" "479.8" "484.9" "503.2" "" "" "" "" "" "" "" "" "" "" "479.0" "433.6" "485.3" "393.7" "462.7" "479.3" "416.8" "426.0" "484.9" "484.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "175169128914004892" "False" "High" "IsMasterProtein" "Q30154" "HLA class II histocompatibility antigen, DR beta 5 chain OS=Homo sapiens OX=9606 GN=HLA-DRB5 PE=1 SV=1" "0.000" "False" "14.604" "18" "4" "5" "2" "266" "30.0" "6.93" "19.20" "4" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00969, Pf07654" "3127" "ENSG00000198502" "HLA-DRB5" "B2RBV6; C7C4X3; hsa:3127; O00157; O00283; O46700; Q29703; Q29787; Q29788; Q30126; Q30150; Q30154; Q30199; Q6SJR2; Q7M2H9; Q8HWS7; Q8WLR5; Q9MY54; Q9XRX6" "Allograft rejection; Ebola virus infection in host; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway" "Interferon gamma signaling; Downstream TCR signaling; MHC class II antigen presentation; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling" "11" "2" "0.995" "1.036" "1.001" "0.978" "1.128" "0.969" "1.045" "1.077" "1.069" "659.5" "656.4" "683.5" "660.2" "645.2" "743.6" "639.2" "689.2" "710.3" "704.8" "" "" "" "" "" "" "" "" "" "" "617.9" "543.1" "634.5" "510.3" "550.0" "710.4" "584.1" "612.0" "710.3" "678.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1674300386967477261" "False" "High" "IsMasterProtein" "Q68CQ4" "U3 small nucleolar RNA-associated protein 25 homolog OS=Homo sapiens OX=9606 GN=UTP25 PE=1 SV=2" "0.000" "False" "14.587" "7" "6" "6" "6" "756" "87.0" "5.88" "11.59" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf06862" "27042" "ENSG00000117597" "UTP25" "hsa:27042; O75992; Q4VY00; Q63HL9; Q68CQ4" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.216" "0.922" "1.302" "1.235" "0.995" "1.177" "0.963" "0.975" "0.935" "83.6" "101.7" "77.1" "108.9" "103.3" "83.2" "98.5" "80.6" "81.5" "78.2" "" "" "" "" "" "" "" "" "" "" "78.4" "84.2" "71.6" "84.2" "88.0" "79.5" "90.0" "71.5" "81.5" "75.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3973865475325375053" "False" "High" "IsMasterProtein" "P15374" "Ubiquitin carboxyl-terminal hydrolase isozyme L3 OS=Homo sapiens OX=9606 GN=UCHL3 PE=1 SV=1" "0.000" "False" "14.583" "25" "5" "9" "5" "230" "26.2" "4.92" "23.97" "5" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01088" "7347" "ENSG00000118939" "UCHL3" "B2R970; hsa:7347; P15374; Q5TBK8; Q6IBE9" "Proteasome degradation" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; UCH proteinases; Neddylation" "4" "0" "1.109" "1.000" "1.017" "1.120" "1.107" "1.059" "1.038" "1.040" "1.068" "209.1" "232.0" "209.2" "212.6" "234.2" "231.4" "221.5" "217.0" "217.5" "223.3" "" "" "" "" "" "" "" "" "" "" "195.9" "192.0" "194.2" "164.4" "199.6" "221.1" "202.4" "192.7" "217.5" "215.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5556518755598623509" "False" "High" "IsMasterProtein" "Q9NQT8" "Kinesin-like protein KIF13B OS=Homo sapiens OX=9606 GN=KIF13B PE=1 SV=2" "0.000" "False" "14.581" "2" "4" "6" "3" "1826" "202.7" "5.88" "17.31" "4" "transport;signal transduction;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf00498, Pf01302, Pf12423, Pf12473, Pf16183" "23303" "ENSG00000197892" "KIF13B" "B4DGY5; B5MC45; F8VPJ2; hsa:23303; O75134; Q9BYJ6; Q9NQT8" "" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "2" "0" "1.137" "1.122" "1.179" "1.219" "0.894" "1.195" "1.020" "1.097" "1.272" "53.1" "60.4" "59.6" "62.6" "64.7" "47.5" "63.4" "54.1" "58.2" "67.5" "" "" "" "" "" "" "" "" "" "" "49.7" "49.9" "55.3" "48.4" "55.1" "45.3" "58.0" "48.1" "58.2" "65.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3818146926309850822" "False" "High" "IsMasterProtein" "O95671" "Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein OS=Homo sapiens OX=9606 GN=ASMTL PE=1 SV=3" "0.000" "False" "14.575" "11" "5" "5" "5" "621" "68.8" "6.07" "17.34" "5" "other metabolic processes" "cytosol" "other molecular function" "Pf00891, Pf02545, Pf16864" "8623" "ENSG00000169093; ENSG00000292339" "ASMTL" "B4DX75; F5GXH4; hsa:8623; J3JS33; O95671; Q5JQ53; Q8NBH5; Q96G02; Q9BUL6" "" "" "0" "0" "0.947" "1.020" "0.912" "1.050" "1.059" "0.954" "0.970" "1.049" "1.118" "93.1" "88.1" "94.9" "84.9" "97.8" "98.5" "88.8" "90.3" "97.6" "104.0" "" "" "" "" "" "" "" "" "" "" "87.2" "72.9" "88.1" "65.6" "83.3" "94.1" "81.1" "80.2" "97.6" "100.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2591568921065242388" "False" "High" "IsMasterProtein" "Q8NB90" "ATPase family gene 2 protein homolog A OS=Homo sapiens OX=9606 GN=AFG2A PE=1 SV=3" "0.000" "False" "14.573" "4" "3" "4" "2" "893" "97.8" "5.66" "15.20" "3" "developmental processes;other biological processes" "cytoskeleton;mitochondrion;other cell component" "other molecular function" "Pf00004, Pf17862" "166378" "ENSG00000145375" "AFG2A" "C9JT97; hsa:166378; Q86XW1; Q8NB90; Q8NI20; Q8TDL7" "" "" "0" "0" "1.039" "1.001" "1.090" "1.066" "1.024" "1.031" "0.913" "0.969" "1.016" "464.0" "482.1" "464.6" "505.7" "494.4" "475.0" "478.5" "423.7" "449.5" "471.4" "" "" "" "" "" "" "" "" "" "" "434.8" "398.9" "431.4" "390.9" "421.4" "453.8" "437.2" "376.2" "449.5" "453.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1430598846084428850" "False" "High" "IsMasterProtein" "Q3B726" "DNA-directed RNA polymerase I subunit RPA43 OS=Homo sapiens OX=9606 GN=POLR1F PE=1 SV=1" "0.000" "False" "14.573" "13" "4" "4" "4" "338" "37.4" "6.98" "15.34" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf03876, Pf17875" "221830" "ENSG00000105849" "POLR1F" "A0PJ45; B7Z724; hsa:221830; Q3B726" "Pyrimidine metabolism; 2q13 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "7" "0" "1.036" "1.037" "1.057" "1.026" "0.981" "1.087" "1.106" "1.083" "1.034" "761.6" "788.9" "790.1" "804.8" "781.1" "747.4" "827.6" "842.1" "824.9" "787.4" "" "" "" "" "" "" "" "" "" "" "713.7" "652.8" "733.5" "622.1" "665.8" "714.0" "756.2" "747.7" "824.9" "758.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9069432479560653681" "False" "High" "IsMasterProtein" "Q08AM6" "Protein VAC14 homolog OS=Homo sapiens OX=9606 GN=VAC14 PE=1 SV=1" "0.000" "False" "14.566" "7" "6" "8" "6" "782" "87.9" "6.13" "21.77" "6" "other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf11916, Pf12755" "55697" "ENSG00000103043" "VAC14" "B3KPJ5; B3KSM8; hsa:55697; Q08AM6; Q13174; Q6IA12; Q7L4Y1; Q9BW96; Q9H6V6" "" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "3" "0" "0.979" "1.019" "0.968" "1.064" "0.963" "0.928" "0.967" "1.026" "1.052" "644.4" "630.6" "656.4" "623.8" "685.6" "620.3" "598.2" "623.2" "661.1" "677.8" "" "" "" "" "" "" "" "" "" "" "603.8" "521.8" "609.4" "482.2" "584.4" "592.6" "546.6" "553.3" "661.1" "652.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4149430532130191750" "False" "High" "IsMasterProtein" "Q13057" "Bifunctional coenzyme A synthase OS=Homo sapiens OX=9606 GN=COASY PE=1 SV=4" "0.000" "False" "14.564" "9" "5" "5" "5" "564" "62.3" "6.99" "16.49" "5" "other metabolic processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf01121, Pf01467" "80347" "ENSG00000068120" "COASY" "B2RA78; B4DLU0; hsa:80347; Q13057; Q6GS23; Q8NBM7; Q8NEW1; Q8WXD4; Q9NRM3" "Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway" "Coenzyme A biosynthesis" "2" "0" "1.057" "0.980" "0.973" "1.020" "1.013" "0.969" "0.956" "0.985" "1.012" "255.4" "270.0" "250.3" "248.7" "260.6" "258.8" "247.6" "244.1" "251.6" "258.4" "" "" "" "" "" "" "" "" "" "" "239.4" "223.5" "232.4" "192.2" "222.1" "247.2" "226.2" "216.8" "251.6" "248.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2020572113107876671" "False" "High" "IsMasterProtein" "Q13643" "Four and a half LIM domains protein 3 OS=Homo sapiens OX=9606 GN=FHL3 PE=1 SV=4" "0.000" "False" "14.556" "19" "5" "5" "5" "280" "31.2" "6.20" "16.35" "5" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00412" "2275" "ENSG00000183386" "FHL3" "D3DPT6; hsa:2275; Q13643; Q6I9T0; Q9BVA2" "" "" "0" "0" "1.004" "1.025" "0.957" "1.003" "0.996" "1.098" "1.162" "1.050" "1.009" "652.4" "654.8" "668.7" "624.3" "654.6" "649.7" "716.4" "758.1" "684.9" "658.2" "" "" "" "" "" "" "" "" "" "" "611.3" "541.9" "620.8" "482.6" "558.0" "620.8" "654.6" "673.1" "684.9" "633.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951709946097313123" "False" "High" "IsMasterProtein" "P78362" "SRSF protein kinase 2 OS=Homo sapiens OX=9606 GN=SRPK2 PE=1 SV=3" "0.000" "False" "14.528" "7" "5" "6" "2" "688" "77.5" "4.97" "17.37" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6733" "ENSG00000135250" "SRPK2" "A8MVX2; hsa:6733; O75220; O75221; P78362; Q6NUL0; Q6V1X2; Q8IYQ3" "mRNA processing" "Maturation of nucleoprotein" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4828769571271312822" "False" "High" "IsMasterProtein" "P46108" "Adapter molecule crk OS=Homo sapiens OX=9606 GN=CRK PE=1 SV=2" "0.000" "False" "14.520" "18" "5" "5" "5" "304" "33.8" "5.55" "15.93" "5" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00017, Pf00018, Pf07653" "1398" "ENSG00000167193" "CRK" "A8MWE8; B0LPE8; D3DTH6; hsa:1398; P46108; Q96GA9; Q96HJ0" "Integrin-mediated cell adhesion; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Rett syndrome; EGF/EGFR signaling pathway; Gastrin signaling pathway; Insulin signaling; Regulation of actin cytoskeleton; GDNF signaling; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "FCGR3A-mediated phagocytosis; Regulation of signaling by CBL; Regulation of actin dynamics for phagocytic cup formation; Downstream signal transduction; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; ARMS-mediated activation; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1; MET receptor recycling" "31" "0" "0.962" "1.018" "1.048" "1.001" "1.063" "0.999" "0.970" "1.037" "1.048" "377.5" "363.1" "384.5" "395.6" "377.8" "401.1" "377.1" "366.3" "391.6" "395.8" "" "" "" "" "" "" "" "" "" "" "353.7" "300.4" "356.9" "305.8" "322.1" "383.3" "344.6" "325.2" "391.6" "381.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3241628752191747033" "False" "High" "IsMasterProtein" "Q9Y6W3" "Calpain-7 OS=Homo sapiens OX=9606 GN=CAPN7 PE=1 SV=1" "0.000" "False" "14.514" "6" "6" "6" "6" "813" "92.6" "7.65" "17.95" "6" "protein metabolism;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00648, Pf01067, Pf04212" "23473" "ENSG00000131375" "CAPN7" "hsa:23473; Q9Y6W3" "Integrin-mediated cell adhesion" "Degradation of the extracellular matrix" "2" "0" "0.971" "1.011" "0.957" "1.016" "1.026" "0.969" "0.975" "0.985" "1.062" "642.8" "624.4" "650.1" "615.5" "653.4" "659.8" "622.9" "626.9" "633.4" "683.0" "" "" "" "" "" "" "" "" "" "" "602.3" "516.7" "603.6" "475.8" "556.9" "630.4" "569.1" "556.7" "633.4" "657.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9211506236520866705" "False" "High" "IsMasterProtein" "O76071" "Probable cytosolic iron-sulfur protein assembly protein CIAO1 OS=Homo sapiens OX=9606 GN=CIAO1 PE=1 SV=1" "0.000" "False" "14.502" "15" "5" "7" "5" "339" "37.8" "4.97" "15.05" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "" "Pf00400" "9391" "ENSG00000144021" "CIAO1" "A0MNN9; hsa:9391; O76071; Q53FM5" "2q11.2 copy number variation syndrome" "Cytosolic iron-sulfur cluster assembly" "2" "0" "1.095" "1.022" "1.148" "1.021" "1.205" "1.205" "1.207" "1.193" "1.236" "60.0" "65.7" "61.3" "68.9" "61.2" "72.3" "72.3" "72.4" "71.5" "74.2" "" "" "" "" "" "" "" "" "" "" "56.2" "54.4" "56.9" "53.3" "52.2" "69.0" "66.0" "64.3" "71.5" "71.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8551730055028160476" "False" "High" "IsMasterProtein" "P08579" "U2 small nuclear ribonucleoprotein B'' OS=Homo sapiens OX=9606 GN=SNRPB2 PE=1 SV=1" "0.000" "False" "14.488" "22" "5" "12" "3" "225" "25.5" "9.72" "43.94" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6629" "ENSG00000125870" "SNRPB2" "B2R7J3; D3DW21; hsa:6629; P08579; Q9UJD4" "mRNA processing; Ciliary landscape" "mRNA Splicing - Major Pathway" "3" "0" "1.094" "1.023" "1.047" "1.059" "1.058" "1.067" "1.099" "1.086" "1.025" "822.0" "899.6" "841.2" "860.9" "870.9" "869.7" "877.4" "903.6" "892.8" "842.7" "" "" "" "" "" "" "" "" "" "" "770.2" "744.4" "780.9" "665.5" "742.3" "830.9" "801.7" "802.3" "892.8" "811.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1319936172901890664" "False" "High" "IsMasterProtein" "P45973" "Chromobox protein homolog 5 OS=Homo sapiens OX=9606 GN=CBX5 PE=1 SV=1" "0.000" "False" "14.479" "26" "6" "7" "6" "191" "22.2" "5.86" "18.06" "6" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00385, Pf01393" "23468" "ENSG00000094916" "CBX5" "B2R8T9; hsa:23468; P45973" "Effect of progerin on genes involved in progeria; 22q11.2 copy number variation syndrome" "Factors involved in megakaryocyte development and platelet production; SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6" "5" "0" "1.015" "1.037" "1.027" "1.044" "0.968" "1.006" "1.036" "0.964" "1.004" "793.8" "805.4" "822.9" "815.2" "828.6" "768.7" "798.4" "822.1" "765.5" "797.3" "" "" "" "" "" "" "" "" "" "" "743.8" "666.4" "763.9" "630.2" "706.2" "734.4" "729.5" "729.9" "765.5" "767.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8127348192762311520" "False" "High" "IsMasterProtein" "Q96HN2" "Adenosylhomocysteinase 3 OS=Homo sapiens OX=9606 GN=AHCYL2 PE=1 SV=1" "0.000" "False" "14.467" "7" "6" "11" "1" "611" "66.7" "7.36" "37.66" "6" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00670, Pf05221" "23382" "ENSG00000158467" "AHCYL2" "B4DIZ5; D9N155; hsa:23382; O94917; Q96HN2" "One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Spina bifida" "Bicarbonate transporters" "4" "0" "0.976" "0.960" "1.071" "0.986" "1.081" "1.025" "1.105" "1.094" "1.000" "375.6" "366.6" "360.6" "402.3" "370.3" "405.9" "385.1" "415.0" "410.8" "375.6" "" "" "" "" "" "" "" "" "" "" "351.9" "303.4" "334.8" "311.0" "315.6" "387.8" "351.9" "368.5" "410.8" "361.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3441790046039018783" "False" "High" "IsMasterProtein" "Q9UQN3" "Charged multivesicular body protein 2b OS=Homo sapiens OX=9606 GN=CHMP2B PE=1 SV=1" "0.000" "False" "14.455" "24" "6" "6" "6" "213" "23.9" "8.76" "17.29" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "25978" "ENSG00000083937" "CHMP2B" "B4DJG8; hsa:25978; Q53HC7; Q9UQN3; Q9Y4U6" "" "Budding and maturation of HIV virion; Macroautophagy; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III; Late endosomal microautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "9" "0" "1.001" "1.019" "0.917" "0.995" "1.015" "0.919" "0.972" "0.954" "0.968" "1272.0" "1273.3" "1296.2" "1166.3" "1266.1" "1291.1" "1168.5" "1235.8" "1213.2" "1231.5" "" "" "" "" "" "" "" "" "" "" "1191.9" "1053.6" "1203.3" "901.6" "1079.2" "1233.5" "1067.7" "1097.3" "1213.2" "1185.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4950317330528062097" "False" "High" "IsMasterProtein" "Q92466" "DNA damage-binding protein 2 OS=Homo sapiens OX=9606 GN=DDB2 PE=1 SV=1" "0.000" "False" "14.450" "11" "4" "5" "4" "427" "47.8" "9.47" "11.73" "4" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "1643" "ENSG00000134574" "DDB2" "B2R875; hsa:1643; Q76E54; Q76E55; Q76E56; Q76E57; Q92466" "miRNA regulation of DNA damage response; miRNA regulation of p53 pathway in prostate cancer; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Small cell lung cancer; Hepatitis B infection; Melanoma; Nucleotide excision repair; DNA repair pathways, full network; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum ; DNA damage response" "Ub-specific processing proteases; TP53 Regulates Transcription of DNA Repair Genes; Dual Incision in GG-NER; Neddylation; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "21" "0" "0.883" "0.946" "0.915" "0.990" "0.945" "0.967" "0.918" "0.911" "0.960" "222.7" "196.8" "210.6" "203.8" "220.5" "210.4" "215.4" "204.5" "203.0" "213.8" "" "" "" "" "" "" "" "" "" "" "208.7" "162.8" "195.6" "157.5" "187.9" "201.0" "196.8" "181.5" "203.0" "205.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4778122268276291111" "False" "High" "IsMasterProtein" "P49406" "Large ribosomal subunit protein bL19m OS=Homo sapiens OX=9606 GN=MRPL19 PE=1 SV=2" "0.000" "False" "14.444" "15" "6" "7" "6" "292" "33.5" "9.50" "19.23" "6" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf01245" "9801" "ENSG00000115364" "MRPL19" "hsa:9801; P49406; Q53TX9; Q96Q52" "Cytoplasmic ribosomal proteins" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "1.009" "1.067" "1.059" "1.062" "1.061" "1.031" "1.050" "1.099" "1.061" "1031.5" "1040.5" "1100.4" "1092.3" "1095.0" "1094.8" "1063.3" "1083.2" "1133.2" "1094.2" "" "" "" "" "" "" "" "" "" "" "966.5" "861.0" "1021.5" "844.4" "933.4" "1046.0" "971.6" "961.8" "1133.2" "1053.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7535964181824527260" "False" "High" "IsMasterProtein" "Q9H0E3" "Histone deacetylase complex subunit SAP130 OS=Homo sapiens OX=9606 GN=SAP130 PE=1 SV=1" "0.000" "False" "14.442" "5" "6" "6" "6" "1048" "110.3" "9.83" "14.63" "6" "other biological processes" "nucleus" "" "Pf16014" "79595" "ENSG00000136715" "SAP130" "B7ZLM3; C9K0X9; hsa:79595; Q4ZFV4; Q53T46; Q8WVW4; Q9H0E3; Q9H9G8" "" "NoRC negatively regulates rRNA expression; HATs acetylate histones" "2" "0" "0.981" "0.965" "1.025" "1.058" "1.000" "1.081" "0.985" "0.987" "1.020" "486.0" "476.8" "468.8" "498.0" "513.9" "485.9" "525.6" "478.8" "479.7" "495.4" "" "" "" "" "" "" "" "" "" "" "455.3" "394.6" "435.2" "385.0" "438.1" "464.2" "480.2" "425.1" "479.7" "477.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7588852199291352544" "False" "High" "IsMasterProtein" "Q68D06" "Schlafen family member 13 OS=Homo sapiens OX=9606 GN=SLFN13 PE=1 SV=1" "0.000" "False" "14.439" "6" "6" "6" "3" "897" "102.0" "6.96" "16.70" "6" "RNA metabolism OR transcription;other metabolic processes;stress response" "other cell component" "nucleic acid binding activity;other molecular function" "Pf04326, Pf09848, Pf17057, Pf21026" "146857" "ENSG00000154760" "SLFN13" "E1P645; hsa:146857; Q658M1; Q68D06; Q6ZS51; Q96A81" "17q12 copy number variation syndrome" "" "1" "0" "0.982" "0.985" "0.999" "0.999" "0.988" "0.903" "0.897" "0.994" "1.018" "546.7" "537.0" "538.6" "546.3" "546.2" "540.1" "493.9" "490.5" "543.6" "556.7" "" "" "" "" "" "" "" "" "" "" "512.2" "444.4" "500.0" "422.3" "465.6" "516.0" "451.3" "435.5" "543.6" "536.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6388610480367959150" "False" "High" "IsMasterProtein" "O15446" "DNA-directed RNA polymerase I subunit RPA34 OS=Homo sapiens OX=9606 GN=POLR1G PE=1 SV=1" "0.000" "False" "14.428" "12" "4" "6" "4" "510" "55.0" "8.51" "22.66" "4" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf08208" "10849" "ENSG00000117877" "POLR1G" "hsa:10849; O15446; Q32N11; Q7Z5U2; Q9UPF6" "2q13 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "6" "0" "1.007" "0.982" "0.946" "1.015" "1.019" "1.120" "1.191" "1.119" "1.048" "1186.1" "1194.9" "1164.9" "1121.5" "1203.9" "1209.1" "1328.8" "1412.8" "1327.2" "1243.4" "" "" "" "" "" "" "" "" "" "" "1111.4" "988.7" "1081.5" "867.0" "1026.1" "1155.2" "1214.2" "1254.4" "1327.2" "1197.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8387303708123169852" "False" "High" "IsMasterProtein" "P07602" "Prosaposin OS=Homo sapiens OX=9606 GN=PSAP PE=1 SV=2" "0.000" "False" "14.400" "9" "5" "5" "5" "524" "58.1" "5.17" "15.91" "5" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf02199, Pf03489, Pf05184" "5660" "ENSG00000197746" "PSAP" "hsa:5660; P07292; P07602; P15793; P78538; P78541; P78546; P78547; P78558; Q53Y86; Q6IBQ6; Q92739; Q92740; Q92741; Q92742" "Degradation pathway of sphingolipids, including diseases" "Neutrophil degranulation; G alpha (i) signalling events; Platelet degranulation ; Peptide ligand-binding receptors; Glycosphingolipid catabolism" "6" "0" "0.993" "0.922" "0.866" "1.022" "1.004" "1.009" "1.005" "0.916" "0.996" "936.9" "930.0" "863.8" "811.7" "957.4" "940.8" "945.7" "941.7" "858.1" "933.4" "" "" "" "" "" "" "" "" "" "" "877.8" "769.6" "801.9" "627.5" "816.0" "898.8" "864.2" "836.1" "858.1" "898.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5775237487534858758" "False" "High" "IsMasterProtein" "P62750" "Large ribosomal subunit protein uL23 OS=Homo sapiens OX=9606 GN=RPL23A PE=1 SV=1" "0.000" "False" "14.399" "37" "6" "8" "6" "156" "17.7" "10.45" "20.46" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00276, Pf03939" "6147" "ENSG00000198242" "RPL23A" "B2R5B2; hsa:6147; P29316; P39024; P62750; Q92774" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.021" "1.130" "1.026" "1.205" "1.177" "1.100" "1.092" "1.115" "1.101" "617.8" "630.8" "698.0" "633.8" "744.3" "726.9" "679.5" "674.9" "689.2" "679.9" "" "" "" "" "" "" "" "" "" "" "578.9" "522.0" "648.0" "489.9" "634.5" "694.5" "620.9" "599.2" "689.2" "654.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7407446589588264140" "False" "High" "IsMasterProtein" "O94763" "Unconventional prefoldin RPB5 interactor 1 OS=Homo sapiens OX=9606 GN=URI1 PE=1 SV=3" "0.000" "False" "14.398" "10" "5" "5" "5" "535" "59.8" "5.05" "14.55" "5" "other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02996" "8725" "ENSG00000105176" "URI1" "A8K805; H7BY42; hsa:8725; O94763; Q8TC23; Q9UNU3" "" "" "0" "0" "0.996" "0.988" "1.096" "1.001" "0.980" "1.053" "0.992" "0.935" "1.006" "766.4" "763.4" "757.3" "839.8" "767.1" "750.8" "806.8" "760.5" "716.4" "771.2" "" "" "" "" "" "" "" "" "" "" "718.2" "631.7" "703.0" "649.2" "653.8" "717.3" "737.2" "675.3" "716.4" "742.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7880695163940437874" "False" "High" "IsMasterProtein" "Q9Y580" "RNA-binding protein 7 OS=Homo sapiens OX=9606 GN=RBM7 PE=1 SV=1" "0.000" "False" "14.396" "17" "4" "4" "4" "266" "30.5" "9.57" "13.82" "4" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "10179" "ENSG00000076053" "RBM7" "B2R6K8; hsa:10179; Q9NUT4; Q9Y580" "" "mRNA Splicing - Major Pathway" "1" "0" "0.961" "0.992" "0.990" "1.019" "0.992" "0.880" "0.896" "0.907" "1.004" "678.5" "652.0" "673.0" "671.9" "691.6" "673.3" "597.1" "607.8" "615.6" "681.5" "" "" "" "" "" "" "" "" "" "" "635.8" "539.5" "624.8" "519.4" "589.5" "643.3" "545.6" "539.6" "615.6" "656.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2673167889447724756" "False" "High" "IsMasterProtein" "Q8IZD4" "mRNA-decapping enzyme 1B OS=Homo sapiens OX=9606 GN=DCP1B PE=1 SV=2" "0.000" "False" "14.387" "8" "5" "6" "5" "617" "67.7" "8.56" "21.31" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf06058, Pf16741" "196513" "ENSG00000151065; ENSG00000284850" "DCP1B" "B4DRD1; hsa:196513; Q86XH9; Q8IZD4; Q96BP8; Q96MZ8" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "1.095" "0.986" "1.007" "0.999" "1.027" "0.964" "0.952" "0.971" "0.991" "506.3" "554.2" "499.4" "509.8" "506.0" "520.0" "488.2" "482.1" "491.6" "501.5" "" "" "" "" "" "" "" "" "" "" "474.4" "458.6" "463.6" "394.1" "431.3" "496.8" "446.1" "428.1" "491.6" "482.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5853605967738796226" "False" "High" "IsMasterProtein" "Q13137" "Calcium-binding and coiled-coil domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CALCOCO2 PE=1 SV=1" "0.000" "False" "14.383" "11" "5" "5" "5" "446" "52.2" "5.02" "14.49" "5" "other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf17751" "10241" "ENSG00000136436" "CALCOCO2" "B2RBT0; B4DDC4; B4DDT4; B4DP36; B4E0C0; E7ENK0; E7ETP5; E9PBE5; hsa:10241; Q13137; Q53FQ5; Q53HB5; Q6IBN9; Q9BTF7" "" "" "0" "0" "0.941" "1.009" "0.981" "1.026" "1.015" "0.951" "1.044" "0.999" "1.041" "746.0" "701.9" "752.9" "731.8" "765.7" "756.9" "709.0" "778.7" "745.2" "776.5" "" "" "" "" "" "" "" "" "" "" "699.0" "580.9" "699.0" "565.7" "652.7" "723.2" "647.9" "691.4" "745.2" "747.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7338451157516248926" "False" "High" "IsMasterProtein" "Q96IZ0" "PRKC apoptosis WT1 regulator protein OS=Homo sapiens OX=9606 GN=PAWR PE=1 SV=1" "0.000" "False" "14.380" "16" "4" "8" "4" "340" "36.5" "5.41" "26.25" "4" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "5074" "ENSG00000177425" "PAWR" "hsa:5074; O75796; Q6FHY9; Q8N700; Q96IZ0" "" "" "0" "0" "1.012" "0.978" "1.045" "1.006" "1.021" "0.990" "1.060" "0.996" "1.024" "788.3" "797.8" "770.7" "823.4" "793.0" "804.7" "780.1" "835.6" "784.8" "807.2" "" "" "" "" "" "" "" "" "" "" "738.6" "660.2" "715.5" "636.5" "675.9" "768.8" "712.8" "741.9" "784.8" "777.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4770714879888361237" "False" "High" "IsMasterProtein" "Q5GLZ8" "Probable E3 ubiquitin-protein ligase HERC4 OS=Homo sapiens OX=9606 GN=HERC4 PE=1 SV=1" "0.000" "False" "14.370" "5" "6" "6" "6" "1057" "118.5" "6.19" "16.51" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00415, Pf00632" "26091" "ENSG00000148634" "HERC4" "hsa:26091; Q5GC98; Q5GC99; Q5GCA0; Q5GLZ8; Q8IXP9; Q9HCH9" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.012" "0.967" "0.995" "0.999" "0.973" "1.030" "0.954" "0.982" "0.962" "873.5" "883.9" "844.7" "868.8" "872.6" "849.6" "899.9" "833.1" "858.0" "840.1" "" "" "" "" "" "" "" "" "" "" "818.5" "731.4" "784.2" "671.6" "743.8" "811.7" "822.3" "739.7" "858.0" "808.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4536625609042411990" "False" "High" "IsMasterProtein" "Q16656" "Nuclear respiratory factor 1 OS=Homo sapiens OX=9606 GN=NRF1 PE=1 SV=1" "0.000" "False" "14.367" "10" "4" "7" "4" "503" "53.5" "5.05" "17.87" "4" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf10491" "4899" "ENSG00000106459" "NRF1" "A8K4C6; B4DDV6; hsa:4899; Q15305; Q16656; Q96AN2" "Energy metabolism; Interactions between LOXL4 and oxidative stress pathway; Mitochondrial gene expression; Sildenafil treatment" "PPARA activates gene expression; Transcriptional activation of mitochondrial biogenesis" "6" "0" "1.115" "0.959" "1.004" "1.014" "1.014" "0.945" "0.955" "0.985" "0.974" "928.1" "1034.5" "890.5" "931.7" "941.4" "940.8" "876.8" "886.6" "914.6" "904.0" "" "" "" "" "" "" "" "" "" "" "869.7" "856.1" "826.7" "720.3" "802.4" "898.8" "801.2" "787.2" "914.6" "870.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7996952704107557877" "False" "High" "IsMasterProtein" "P28331" "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS1 PE=1 SV=3" "0.000" "False" "14.355" "7" "5" "7" "5" "727" "79.4" "6.23" "16.06" "5" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00384, Pf09326, Pf10588, Pf13510" "4719" "ENSG00000023228; ENSG00000283447" "NDUFS1" "B4DIN9; B4DJA0; B4DPG1; B4DUC1; E7ENF3; hsa:4719; P28331; Q53TR8; Q8N1C4; Q8TCC9" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis; Mitochondrial protein degradation" "6" "0" "1.004" "1.027" "0.963" "1.033" "1.015" "0.873" "0.895" "0.996" "0.953" "313.9" "315.2" "322.3" "302.3" "324.3" "318.5" "274.1" "280.8" "312.7" "299.2" "" "" "" "" "" "" "" "" "" "" "294.1" "260.8" "299.2" "233.7" "276.4" "304.3" "250.4" "249.3" "312.7" "288.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3220884936245267041" "False" "High" "IsMasterProtein" "Q8WUA7" "TBC1 domain family member 22A OS=Homo sapiens OX=9606 GN=TBC1D22A PE=1 SV=2" "0.000" "False" "14.353" "10" "6" "7" "5" "517" "59.1" "5.97" "18.92" "6" "" "" "enzyme regulator activity;other molecular function" "Pf00566" "25771" "ENSG00000054611" "TBC1D22A" "B0QYI2; B0QYI3; B9A6M3; hsa:25771; Q5TE47; Q6ZUH2; Q8WUA7; Q92680; Q9BVD6; Q9UGG0; Q9UGT2; Q9UGU6; Q9UH25; Q9Y4W5" "" "" "0" "0" "0.938" "1.009" "1.192" "1.006" "0.974" "1.049" "0.929" "1.081" "1.033" "220.7" "207.1" "222.7" "263.2" "222.0" "215.0" "231.5" "205.1" "238.6" "228.0" "" "" "" "" "" "" "" "" "" "" "206.8" "171.4" "206.7" "203.4" "189.2" "205.4" "211.5" "182.1" "238.6" "219.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4563440572163449089" "False" "High" "IsMasterProtein" "P60520" "Gamma-aminobutyric acid receptor-associated protein-like 2 OS=Homo sapiens OX=9606 GN=GABARAPL2 PE=1 SV=1" "0.000" "False" "14.351" "42" "5" "9" "4" "117" "13.7" "8.10" "24.97" "5" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02991" "11345" "ENSG00000034713" "GABARAPL2" "hsa:11345; O08765; P60520; Q6FG91; Q9DCP8; Q9UQF7" "Network map of SARS-CoV-2 signaling pathway; 2q37 copy number variation syndrome; 8q11.23 (RB1CC1) copy number variation" "TBC/RABGAPs; Macroautophagy" "5" "1" "0.963" "1.000" "0.950" "1.012" "1.053" "0.983" "0.998" "0.964" "1.024" "604.7" "582.2" "604.7" "574.2" "612.2" "636.7" "594.2" "603.6" "583.0" "619.0" "" "" "" "" "" "" "" "" "" "" "566.6" "481.8" "561.4" "443.9" "521.8" "608.3" "542.9" "535.9" "583.0" "596.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7801299591553380074" "False" "High" "IsMasterProtein" "P52298" "Nuclear cap-binding protein subunit 2 OS=Homo sapiens OX=9606 GN=NCBP2 PE=1 SV=1" "0.000" "False" "14.307" "27" "5" "9" "5" "156" "18.0" "8.21" "23.01" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "22916" "ENSG00000114503" "NCBP2" "B2RE91; B4DMK7; E9PAR5; hsa:22916; P52298; Q14924; Q2TS50" "mRNA processing; 3q29 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes; Regulation of expression of SLITs and ROBOs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Polymerase II Pre-transcription Events; mRNA Capping; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; snRNP Assembly; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Processing of Intronless Pre-mRNAs; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "29" "0" "1.095" "1.090" "1.066" "1.022" "1.032" "1.104" "1.081" "1.126" "1.055" "495.6" "542.8" "540.0" "528.3" "506.2" "511.3" "547.0" "535.8" "557.9" "522.9" "" "" "" "" "" "" "" "" "" "" "464.3" "449.2" "501.3" "408.4" "431.5" "488.5" "499.8" "475.8" "557.9" "503.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "945913478307562709" "False" "High" "IsMasterProtein" "Q9Y2Q9" "Small ribosomal subunit protein bS1m OS=Homo sapiens OX=9606 GN=MRPS28 PE=1 SV=1" "0.000" "False" "14.302" "29" "6" "6" "6" "187" "20.8" "9.10" "15.33" "6" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf10246" "28957" "ENSG00000147586" "MRPS28" "B2RDZ7; hsa:28957; Q96Q21; Q9Y2Q9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.106" "1.009" "1.096" "1.004" "1.006" "1.173" "0.952" "0.950" "1.041" "171.2" "189.4" "172.8" "187.6" "172.0" "172.2" "200.8" "163.0" "162.8" "178.2" "" "" "" "" "" "" "" "" "" "" "160.5" "156.7" "160.5" "145.1" "146.6" "164.5" "183.5" "144.7" "162.8" "171.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8075154103448429091" "False" "High" "IsMasterProtein" "O94927" "HAUS augmin-like complex subunit 5 OS=Homo sapiens OX=9606 GN=HAUS5 PE=1 SV=2" "0.000" "False" "14.302" "9" "5" "6" "5" "633" "71.6" "8.51" "20.49" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf14817" "23354" "ENSG00000249115" "HAUS5" "B2RXK1; hsa:23354; O94927; Q6P2P7; Q7L3D5; Q96CT8" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "1.130" "1.043" "1.111" "1.099" "1.009" "1.070" "1.000" "1.007" "1.034" "490.7" "554.4" "512.0" "545.3" "539.4" "495.1" "524.9" "490.6" "494.0" "507.3" "" "" "" "" "" "" "" "" "" "" "459.8" "458.7" "475.3" "421.5" "459.7" "473.0" "479.6" "435.6" "494.0" "488.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3338411764392514561" "False" "High" "IsMasterProtein" "P45954" "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADSB PE=1 SV=1" "0.000" "False" "14.301" "11" "4" "5" "4" "432" "47.5" "6.99" "18.36" "4" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "36" "ENSG00000196177" "ACADSB" "B4DQ51; hsa:36; P45954; Q5SQN6; Q96CX7" "Valproic acid pathway" "Mitochondrial protein degradation; Branched-chain amino acid catabolism" "3" "0" "0.960" "1.046" "0.964" "1.011" "0.993" "0.954" "0.973" "0.990" "1.004" "733.7" "704.7" "767.1" "707.5" "741.8" "728.7" "700.2" "713.8" "726.6" "736.4" "" "" "" "" "" "" "" "" "" "" "687.5" "583.1" "712.2" "546.9" "632.3" "696.2" "639.8" "633.8" "726.6" "709.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4381387929152042020" "False" "High" "IsMasterProtein" "Q9ULX3" "RNA-binding protein NOB1 OS=Homo sapiens OX=9606 GN=NOB1 PE=1 SV=1" "0.000" "False" "14.283" "11" "6" "8" "6" "412" "46.6" "7.18" "20.74" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08772, Pf15017, Pf17146" "28987" "ENSG00000141101" "NOB1" "hsa:28987; Q7L6B7; Q7M4M4; Q7Z4B5; Q9NWB0; Q9ULX3" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.014" "1.004" "1.029" "1.061" "1.123" "1.028" "0.992" "1.021" "1.047" "550.9" "558.9" "553.0" "567.0" "584.5" "618.5" "566.5" "546.7" "562.3" "576.6" "" "" "" "" "" "" "" "" "" "" "516.2" "462.5" "513.4" "438.3" "498.2" "590.9" "517.6" "485.4" "562.3" "555.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4835883825689200365" "False" "High" "IsMasterProtein" "Q92979" "Ribosomal RNA small subunit methyltransferase NEP1 OS=Homo sapiens OX=9606 GN=EMG1 PE=1 SV=4" "0.000" "False" "14.272" "20" "5" "5" "5" "244" "26.7" "9.17" "17.96" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03587" "10436" "ENSG00000126749" "EMG1" "hsa:10436; O00675; O00726; Q92979" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.044" "1.071" "1.068" "0.944" "1.094" "1.117" "1.206" "1.166" "1.080" "938.8" "979.8" "1005.6" "1002.2" "886.1" "1026.7" "1048.6" "1132.6" "1094.3" "1014.0" "" "" "" "" "" "" "" "" "" "" "879.6" "810.7" "933.5" "774.7" "755.3" "980.9" "958.1" "1005.7" "1094.3" "976.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6212598245542673461" "False" "High" "IsMasterProtein" "Q92879" "CUGBP Elav-like family member 1 OS=Homo sapiens OX=9606 GN=CELF1 PE=1 SV=2" "0.000" "False" "14.268" "10" "6" "9" "4" "486" "52.0" "8.46" "25.25" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "10658" "ENSG00000149187" "CELF1" "B4E2U5; D3DQS0; F8W940; Q4LE52; Q92879; Q9NP83; Q9NR06" "Adipogenesis; mRNA processing" "" "2" "0" "0.981" "0.955" "0.952" "0.945" "0.961" "0.890" "0.822" "1.026" "0.977" "1309.9" "1285.6" "1251.3" "1246.6" "1238.4" "1258.7" "1165.7" "1076.6" "1343.6" "1279.8" "" "" "" "" "" "" "" "" "" "" "1227.3" "1063.8" "1161.7" "963.6" "1055.5" "1202.6" "1065.1" "955.9" "1343.6" "1232.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-973328225883047536" "False" "High" "IsMasterProtein" "Q8IV48" "3'-5' exoribonuclease 1 OS=Homo sapiens OX=9606 GN=ERI1 PE=1 SV=3" "0.000" "False" "14.261" "14" "5" "6" "5" "349" "40.0" "6.70" "18.57" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00929, Pf02037" "90459" "ENSG00000104626" "ERI1" "A8K4U7; hsa:90459; Q8IV48; Q9NSX3" "exRNA mechanism of action and biogenesis; 8p23.1 copy number variation syndrome; 4p16.3 copy number variation" "Major pathway of rRNA processing in the nucleolus and cytosol" "4" "0" "0.983" "0.928" "0.913" "0.965" "0.956" "0.906" "0.878" "0.919" "0.948" "967.4" "950.9" "897.4" "883.1" "933.7" "925.1" "876.0" "849.5" "889.3" "917.3" "" "" "" "" "" "" "" "" "" "" "906.4" "786.9" "833.1" "682.7" "795.9" "883.9" "800.4" "754.3" "889.3" "883.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6843403857140785601" "False" "High" "IsMasterProtein" "Q8NBL1" "Protein O-glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POGLUT1 PE=1 SV=1" "0.000" "False" "14.257" "11" "6" "7" "6" "392" "46.2" "8.72" "16.31" "6" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf05686" "56983" "ENSG00000163389" "POGLUT1" "B2RD13; hsa:56983; Q53GJ4; Q8N2T1; Q8NBL1" "" "Pre-NOTCH Processing in the Endoplasmic Reticulum" "1" "0" "0.952" "1.008" "1.019" "1.084" "1.012" "0.987" "0.991" "1.010" "1.043" "869.6" "828.0" "876.6" "886.3" "942.2" "879.6" "858.5" "861.9" "877.8" "907.1" "" "" "" "" "" "" "" "" "" "" "814.8" "685.2" "813.8" "685.1" "803.1" "840.4" "784.4" "765.2" "877.8" "873.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8826261878749587371" "False" "High" "IsMasterProtein" "P39023" "Large ribosomal subunit protein uL3 OS=Homo sapiens OX=9606 GN=RPL3 PE=1 SV=2" "0.000" "False" "14.253" "13" "7" "10" "7" "403" "46.1" "10.18" "17.73" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00297" "6122" "ENSG00000100316" "RPL3" "B2RDV9; hsa:6122; P39023; Q15548; Q5I0G0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.036" "1.079" "1.114" "1.160" "1.181" "1.310" "1.314" "1.173" "1.124" "885.9" "917.9" "955.6" "987.1" "1027.7" "1046.6" "1160.5" "1164.1" "1039.2" "995.7" "" "" "" "" "" "" "" "" "" "" "830.1" "759.6" "887.2" "763.1" "876.0" "1000.0" "1060.4" "1033.6" "1039.2" "958.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5758316461638693187" "False" "High" "IsMasterProtein" "Q05519" "Serine/arginine-rich splicing factor 11 OS=Homo sapiens OX=9606 GN=SRSF11 PE=1 SV=1" "0.000" "False" "14.252" "11" "4" "6" "4" "484" "53.5" "10.52" "15.01" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00076" "9295" "ENSG00000116754" "SRSF11" "hsa:9295; Q05519; Q5T758; Q8IWE6" "" "mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "5" "0" "1.153" "1.150" "1.087" "1.059" "1.062" "1.103" "1.072" "1.014" "1.119" "493.2" "568.8" "567.1" "536.3" "522.4" "524.0" "544.1" "528.8" "500.1" "552.0" "" "" "" "" "" "" "" "" "" "" "462.1" "470.7" "526.4" "414.6" "445.3" "500.6" "497.1" "469.5" "500.1" "531.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6550652705279003104" "False" "High" "IsMasterProtein" "P50552" "Vasodilator-stimulated phosphoprotein OS=Homo sapiens OX=9606 GN=VASP PE=1 SV=3" "0.000" "False" "14.247" "11" "4" "4" "4" "380" "39.8" "8.94" "14.17" "4" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "7408" "ENSG00000125753" "VASP" "B2RBT9; hsa:7408; P50552; Q6PIZ1; Q93035" "Integrin-mediated cell adhesion; Focal adhesion" "Generation of second messenger molecules; Signaling by ROBO receptors; Cell-extracellular matrix interactions" "5" "0" "0.982" "1.062" "1.006" "0.975" "1.061" "1.062" "1.017" "0.966" "1.029" "397.2" "390.1" "421.7" "399.6" "387.2" "421.5" "421.9" "404.0" "383.8" "408.8" "" "" "" "" "" "" "" "" "" "" "372.1" "322.8" "391.5" "308.9" "330.0" "402.7" "385.5" "358.7" "383.8" "393.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4729149100999833326" "False" "High" "IsMasterProtein" "Q9NT62" "Ubiquitin-like-conjugating enzyme ATG3 OS=Homo sapiens OX=9606 GN=ATG3 PE=1 SV=1" "0.000" "False" "14.244" "17" "5" "6" "5" "314" "35.8" "4.74" "18.91" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf03987" "64422" "ENSG00000144848" "ATG3" "hsa:64422; Q6PKC5; Q9H6L9; Q9NT62" "Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "6" "0" "1.006" "1.068" "0.991" "0.985" "1.036" "0.928" "0.999" "0.962" "0.993" "924.4" "929.7" "986.8" "915.9" "910.8" "957.4" "857.9" "923.4" "889.0" "917.7" "" "" "" "" "" "" "" "" "" "" "866.1" "769.3" "916.1" "708.0" "776.4" "914.7" "783.9" "819.8" "889.0" "883.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5097662091813912850" "False" "High" "IsMasterProtein" "Q02252" "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial OS=Homo sapiens OX=9606 GN=ALDH6A1 PE=1 SV=2" "0.000" "False" "14.241" "7" "4" "6" "4" "535" "57.8" "8.50" "20.00" "4" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf00171" "4329" "ENSG00000119711" "ALDH6A1" "B2R609; B4DFS8; hsa:4329; J3KNU8; Q02252; Q9UKM8" "" "Branched-chain amino acid catabolism" "1" "0" "1.041" "1.061" "1.087" "0.953" "1.065" "1.035" "0.962" "0.985" "0.978" "165.1" "171.9" "175.2" "179.5" "157.4" "175.9" "170.9" "158.8" "162.7" "161.5" "" "" "" "" "" "" "" "" "" "" "154.7" "142.3" "162.6" "138.7" "134.1" "168.1" "156.2" "141.0" "162.7" "155.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-204711257539491149" "False" "High" "IsMasterProtein" "O96017" "Serine/threonine-protein kinase Chk2 OS=Homo sapiens OX=9606 GN=CHEK2 PE=1 SV=1" "0.000" "False" "14.238" "9" "6" "7" "5" "543" "60.9" "5.91" "21.76" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00498" "11200" "ENSG00000183765" "CHEK2" "A8K3Y9; B7ZBF3; B7ZBF4; B7ZBF5; hsa:11200; O96017; Q6QA03; Q6QA04; Q6QA05; Q6QA06; Q6QA07; Q6QA08; Q6QA10; Q6QA11; Q6QA12; Q6QA13; Q9HBS5; Q9HCQ8; Q9UGF0; Q9UGF1" "miRNA regulation of DNA damage response; Cell cycle; ATM signaling in development and disease ; miRNA regulation of p53 pathway in prostate cancer; DNA damage response" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Regulation of TP53 Activity through Methylation; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Stabilization of p53" "13" "0" "0.981" "0.985" "0.992" "0.992" "0.984" "1.023" "0.972" "1.041" "1.033" "1068.3" "1048.4" "1051.9" "1059.3" "1059.5" "1050.9" "1093.2" "1038.3" "1112.1" "1103.2" "" "" "" "" "" "" "" "" "" "" "1001.0" "867.5" "976.6" "818.9" "903.1" "1004.0" "998.9" "921.9" "1112.1" "1062.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1964659957025433859" "False" "High" "IsMasterProtein" "Q9H2H8" "Peptidyl-prolyl cis-trans isomerase-like 3 OS=Homo sapiens OX=9606 GN=PPIL3 PE=1 SV=1" "0.000" "False" "14.217" "28" "4" "9" "4" "161" "18.1" "6.79" "22.27" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00160" "53938" "ENSG00000240344" "PPIL3" "hsa:53938; Q86WF9; Q96IA9; Q9BXZ1; Q9H2H8" "" "mRNA Splicing - Major Pathway" "1" "0" "1.051" "1.037" "1.156" "1.079" "1.073" "1.101" "1.049" "1.035" "1.074" "612.3" "643.7" "634.6" "707.5" "660.8" "656.8" "674.1" "642.2" "633.6" "657.3" "" "" "" "" "" "" "" "" "" "" "573.7" "532.6" "589.2" "547.0" "563.2" "627.5" "615.9" "570.2" "633.6" "632.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6594093010420554285" "False" "High" "IsMasterProtein" "Q9NWZ3" "Interleukin-1 receptor-associated kinase 4 OS=Homo sapiens OX=9606 GN=IRAK4 PE=1 SV=1" "0.000" "False" "14.189" "11" "5" "5" "5" "460" "51.5" "5.41" "17.60" "5" "other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf07714" "51135" "ENSG00000198001" "IRAK4" "hsa:51135; Q69FE1; Q8TDF7; Q9NWZ3; Q9Y589" "IL-1 signaling pathway; AGE/RAGE pathway; Interleukin-1 (IL-1) structural pathway; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Fibrin complement receptor 3 signaling pathway; miRNA role in immune response in sepsis; LTF danger signal response pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Toll-like receptor signaling pathway" "Interleukin-1 signaling; PIP3 activates AKT signaling; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; IRAK4 deficiency (TLR2/4); PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; MyD88 cascade initiated on plasma membrane; IRAK4 deficiency (TLR5); TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "23" "0" "0.912" "0.987" "0.931" "0.952" "0.918" "0.865" "0.932" "0.889" "0.969" "967.4" "882.5" "954.5" "900.6" "921.1" "888.1" "836.8" "902.1" "860.2" "937.4" "" "" "" "" "" "" "" "" "" "" "906.5" "730.3" "886.2" "696.2" "785.1" "848.5" "764.6" "801.0" "860.2" "902.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8751597953454221886" "False" "High" "IsMasterProtein" "P09496" "Clathrin light chain A OS=Homo sapiens OX=9606 GN=CLTA PE=1 SV=1" "0.000" "False" "14.170" "16" "5" "9" "5" "248" "27.1" "4.51" "29.14" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01086" "1211" "ENSG00000122705" "CLTA" "A8K4W3; B4DIN1; F5H6N3; hsa:1211; P09496; Q2XPN5; Q53XZ1" "Synaptic vesicle pathway; Ebola virus infection in host; Fragile X syndrome" "Recycling pathway of L1; MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Entry of Influenza Virion into Host Cell via Endocytosis; Formation of annular gap junctions" "17" "0" "1.004" "0.959" "0.983" "1.001" "0.963" "1.056" "1.019" "0.947" "0.964" "1011.4" "1015.8" "970.1" "994.1" "1012.8" "973.6" "1067.7" "1030.7" "958.2" "974.5" "" "" "" "" "" "" "" "" "" "" "947.6" "840.6" "900.7" "768.5" "863.3" "930.2" "975.6" "915.2" "958.2" "938.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "588939397575272440" "False" "High" "IsMasterProtein" "Q7L2J0" "7SK snRNA methylphosphate capping enzyme OS=Homo sapiens OX=9606 GN=MEPCE PE=1 SV=1" "0.000" "False" "14.169" "8" "5" "5" "5" "689" "74.3" "9.57" "19.16" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06859" "56257" "ENSG00000146834" "MEPCE" "B3KP86; D6W5V7; hsa:56257; Q7L2J0; Q9NPD4" "IL-18 signaling pathway; 1p36 copy number variation syndrome" "" "2" "0" "0.982" "0.965" "0.977" "1.011" "1.010" "1.094" "1.046" "1.086" "1.061" "338.4" "332.2" "326.7" "330.8" "342.1" "341.8" "370.1" "354.0" "367.4" "359.1" "" "" "" "" "" "" "" "" "" "" "317.1" "274.9" "303.3" "255.7" "291.6" "326.6" "338.1" "314.4" "367.4" "345.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6144698658960758490" "False" "High" "IsMasterProtein" "Q8IXB1" "DnaJ homolog subfamily C member 10 OS=Homo sapiens OX=9606 GN=DNAJC10 PE=1 SV=2" "0.000" "False" "14.168" "6" "5" "6" "5" "793" "91.0" "7.18" "13.64" "5" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi" "other molecular function" "Pf00085, Pf00226" "54431" "ENSG00000077232" "DNAJC10" "hsa:54431; Q17RJ6; Q3B7W8; Q4ZG06; Q53QT7; Q6UWZ6; Q86T61; Q8IXB1; Q8NC82; Q8TD87; Q96K38; Q96K44; Q96K54; Q9NSY6" "" "" "0" "0" "1.014" "0.987" "1.011" "1.040" "1.059" "0.965" "0.994" "1.012" "1.010" "550.1" "557.6" "543.2" "556.3" "572.4" "582.8" "530.8" "547.0" "556.7" "555.8" "" "" "" "" "" "" "" "" "" "" "515.5" "461.4" "504.2" "430.1" "487.9" "556.8" "485.0" "485.7" "556.7" "535.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4361926129006051556" "False" "High" "IsMasterProtein" "Q9BSH4" "Translational activator of cytochrome c oxidase 1 OS=Homo sapiens OX=9606 GN=TACO1 PE=1 SV=1" "0.000" "False" "14.162" "14" "4" "4" "4" "297" "32.5" "8.13" "15.16" "4" "cell organization and biogenesis;other biological processes" "mitochondrion" "translation activity;nucleic acid binding activity" "Pf01709, Pf20772" "51204" "ENSG00000136463" "TACO1" "B2RD21; hsa:51204; Q8N3N6; Q9BSH4; Q9UI60" "Mitochondrial complex IV assembly" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "4" "0" "0.958" "1.053" "0.947" "0.944" "0.997" "0.949" "0.935" "0.966" "0.980" "589.5" "564.9" "620.4" "558.3" "556.3" "587.8" "559.6" "551.3" "569.2" "577.8" "" "" "" "" "" "" "" "" "" "" "552.3" "467.4" "576.0" "431.6" "474.1" "561.6" "511.4" "489.5" "569.2" "556.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4853611610042411436" "False" "High" "IsMasterProtein" "Q04760" "Lactoylglutathione lyase OS=Homo sapiens OX=9606 GN=GLO1 PE=1 SV=4" "0.000" "False" "14.148" "18" "5" "14" "5" "184" "20.8" "5.31" "34.56" "5" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00903" "2739" "ENSG00000124767" "GLO1" "B2R6P7; B4DDV0; hsa:2739; P78375; Q04760; Q59EL0; Q5TZW3; Q96FC0; Q96J41" "" "Pyruvate metabolism" "1" "0" "1.091" "0.968" "0.920" "0.983" "0.918" "0.962" "1.015" "1.009" "0.940" "1379.8" "1504.9" "1336.2" "1268.8" "1356.6" "1266.3" "1327.8" "1400.5" "1391.8" "1297.0" "" "" "" "" "" "" "" "" "" "" "1292.9" "1245.3" "1240.5" "980.9" "1156.3" "1209.8" "1213.2" "1243.5" "1391.8" "1248.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6592618097650740774" "False" "High" "IsMasterProtein" "Q9UDY2" "Tight junction protein ZO-2 OS=Homo sapiens OX=9606 GN=TJP2 PE=1 SV=2" "0.000" "False" "14.144" "5" "5" "5" "5" "1190" "133.9" "7.40" "15.01" "5" "cell adhesion;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00595, Pf00625, Pf07653" "9414" "ENSG00000119139" "TJP2" "A2A3H9; B7Z2R8; B7Z7T6; F5H301; F5H886; hsa:9414; Q15883; Q5VXL0; Q5VXL1; Q8N756; Q8NI14; Q99839; Q9UDY0; Q9UDY1; Q9UDY2" "1q21.1 copy number variation syndrome; 15q11q13 copy number variation" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Signaling by Hippo; Apoptotic cleavage of cell adhesion proteins" "7" "0" "1.102" "0.980" "1.285" "1.054" "1.160" "1.209" "1.142" "1.078" "1.108" "148.0" "163.1" "144.9" "190.2" "156.0" "171.7" "178.9" "168.9" "159.5" "163.9" "" "" "" "" "" "" "" "" "" "" "138.6" "135.0" "134.6" "147.0" "132.9" "164.0" "163.5" "150.0" "159.5" "157.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8529586358305545684" "False" "High" "IsMasterProtein" "P04181" "Ornithine aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=OAT PE=1 SV=1" "0.000" "False" "14.137" "12" "5" "6" "5" "439" "48.5" "7.03" "19.28" "5" "other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00202" "4942" "ENSG00000065154" "OAT" "D3DRF0; hsa:4942; P04181; Q16068; Q16069; Q68CS0; Q6IAV9; Q9UD03" "Amino acid metabolism; 22q11.2 copy number variation syndrome; Creatine pathway" "Glutamate and glutamine metabolism" "4" "0" "0.941" "1.020" "1.014" "0.988" "0.938" "0.999" "0.939" "0.883" "0.902" "391.6" "368.4" "399.4" "397.2" "386.9" "367.4" "391.3" "367.8" "346.0" "353.3" "" "" "" "" "" "" "" "" "" "" "366.9" "304.8" "370.8" "307.0" "329.8" "351.0" "357.5" "326.6" "346.0" "340.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "274876564336853802" "False" "High" "IsMasterProtein" "Q01804" "OTU domain-containing protein 4 OS=Homo sapiens OX=9606 GN=OTUD4 PE=1 SV=4" "0.000" "False" "14.116" "4" "5" "6" "5" "1114" "124.0" "6.71" "16.39" "5" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02338" "54726" "ENSG00000164164" "OTUD4" "B4DYS4; hsa:54726; Q01804; Q147U2; Q1ZYK1; Q6PG39; Q96MQ5; Q9NT94; Q9UPV6" "" "" "0" "0" "1.003" "1.021" "1.114" "1.055" "1.088" "1.172" "1.099" "1.145" "1.118" "599.9" "601.7" "612.5" "668.1" "632.9" "652.9" "703.2" "659.1" "687.0" "670.4" "" "" "" "" "" "" "" "" "" "" "562.1" "497.9" "568.6" "516.5" "539.4" "623.8" "642.5" "585.2" "687.0" "645.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7331213768411445402" "False" "High" "IsMasterProtein" "O95777" "U6 snRNA-associated Sm-like protein LSm8 OS=Homo sapiens OX=9606 GN=LSM8 PE=1 SV=3" "0.000" "False" "14.113" "61" "4" "7" "4" "96" "10.4" "4.48" "24.82" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "51691" "ENSG00000128534" "LSM8" "hsa:51691; O95777" "" "mRNA Splicing - Major Pathway" "1" "0" "1.093" "0.950" "1.121" "0.992" "0.927" "1.156" "0.990" "0.992" "0.977" "527.6" "576.5" "501.3" "591.2" "523.5" "489.4" "609.7" "522.3" "523.2" "515.7" "" "" "" "" "" "" "" "" "" "" "494.4" "477.1" "465.4" "457.1" "446.2" "467.6" "557.1" "463.8" "523.2" "496.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-981252296573627161" "False" "High" "IsMasterProtein" "Q8NCN4" "E3 ubiquitin-protein ligase RNF169 OS=Homo sapiens OX=9606 GN=RNF169 PE=1 SV=2" "0.000" "False" "14.112" "6" "5" "5" "5" "708" "77.1" "9.10" "16.83" "5" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13920" "254225" "ENSG00000166439" "RNF169" "hsa:254225; Q6N015; Q8NCN4" "" "" "0" "0" "0.968" "1.009" "1.051" "1.085" "1.041" "1.010" "1.017" "1.002" "1.030" "507.7" "491.4" "512.4" "533.8" "551.0" "528.3" "512.6" "516.5" "508.6" "523.1" "" "" "" "" "" "" "" "" "" "" "475.7" "406.6" "475.7" "412.6" "469.7" "504.8" "468.4" "458.6" "508.6" "503.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8605151959694531472" "False" "High" "IsMasterProtein" "Q13888" "General transcription factor IIH subunit 2 OS=Homo sapiens OX=9606 GN=GTF2H2 PE=1 SV=1" "0.000" "False" "14.106" "13" "6" "6" "6" "395" "44.4" "6.76" "13.39" "6" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "nucleus" "other molecular function" "Pf04056, Pf07975" "2966" "ENSG00000145736; ENSG00000275045; ENSG00000276910" "GTF2H2" "hsa:2966; Q13888; Q15570; Q15571; Q9BS41" "Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "33" "0" "0.936" "1.061" "0.954" "1.071" "1.060" "0.999" "1.036" "1.037" "1.120" "289.6" "271.0" "307.3" "276.2" "310.1" "306.9" "289.3" "300.0" "300.3" "324.2" "" "" "" "" "" "" "" "" "" "" "271.3" "224.3" "285.3" "213.5" "264.4" "293.3" "264.3" "266.4" "300.3" "312.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4846658872779087383" "False" "High" "IsMasterProtein" "P61964" "WD repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=WDR5 PE=1 SV=1" "0.000" "False" "14.089" "16" "5" "5" "5" "334" "36.6" "8.27" "16.83" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400" "11091" "ENSG00000196363" "WDR5" "hsa:11091; P61964; Q91VA5; Q9NWX7; Q9UGP9" "Pleural mesothelioma; Kleefstra syndrome" "Neddylation; Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RMTs methylate histone arginines; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Cardiogenesis" "10" "0" "1.016" "1.018" "1.022" "0.903" "1.025" "1.014" "0.965" "0.926" "0.950" "537.2" "545.9" "547.1" "549.1" "485.2" "550.6" "544.9" "518.4" "497.2" "510.3" "" "" "" "" "" "" "" "" "" "" "503.4" "451.7" "507.9" "424.5" "413.6" "526.0" "497.9" "460.3" "497.2" "491.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9134021061211319467" "False" "High" "IsMasterProtein" "Q9HA77" "Probable cysteine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=CARS2 PE=1 SV=1" "0.000" "False" "14.075" "9" "5" "7" "5" "564" "62.2" "8.34" "20.53" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01406" "79587" "ENSG00000134905" "CARS2" "hsa:79587; Q8NI84; Q96IV4; Q9HA77" "" "Mitochondrial tRNA aminoacylation" "1" "0" "0.956" "0.998" "0.961" "0.993" "1.050" "0.915" "1.027" "0.989" "1.031" "504.2" "482.1" "503.4" "484.6" "500.8" "529.3" "461.3" "518.0" "498.5" "519.8" "" "" "" "" "" "" "" "" "" "" "472.5" "399.0" "467.4" "374.6" "426.9" "505.7" "421.5" "459.9" "498.5" "500.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2901873737565675382" "False" "High" "IsMasterProtein" "O95825" "Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=2" "0.000" "False" "14.073" "16" "5" "6" "5" "349" "38.7" "5.78" "19.28" "5" "other metabolic processes" "" "other molecular function" "" "9946" "ENSG00000205758" "CRYZL1" "B2RDX1; B3KQ77; hsa:9946; O95825; Q96DY0; Q9NVY7" "" "" "0" "0" "1.021" "1.038" "1.022" "1.024" "1.042" "1.016" "1.081" "1.023" "0.992" "745.5" "761.4" "773.5" "762.3" "763.4" "777.0" "757.7" "805.7" "762.4" "739.6" "" "" "" "" "" "" "" "" "" "" "698.6" "630.0" "718.1" "589.3" "650.7" "742.4" "692.3" "715.4" "762.4" "712.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3559199072785365377" "False" "High" "IsMasterProtein" "Q14493" "Histone RNA hairpin-binding protein OS=Homo sapiens OX=9606 GN=SLBP PE=1 SV=1" "0.000" "False" "14.057" "20" "5" "9" "5" "270" "31.3" "7.47" "25.30" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15247" "7884" "ENSG00000163950" "SLBP" "B3KRJ5; hsa:7884; Q14493" "8p23.1 copy number variation syndrome; 4p16.3 copy number variation" "RNA Polymerase II Transcription Termination; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; Transport of the SLBP Dependant Mature mRNA" "5" "0" "1.014" "0.984" "1.040" "1.075" "1.071" "1.039" "1.055" "1.037" "1.001" "843.7" "855.4" "830.2" "877.1" "906.7" "903.8" "876.7" "890.2" "875.2" "844.4" "" "" "" "" "" "" "" "" "" "" "790.5" "707.9" "770.7" "678.1" "772.8" "863.5" "801.1" "790.4" "875.2" "813.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1395564513229487982" "False" "High" "IsMasterProtein" "O94826" "Mitochondrial import receptor subunit TOM70 OS=Homo sapiens OX=9606 GN=TOMM70 PE=1 SV=1" "0.000" "False" "14.046" "8" "6" "7" "6" "608" "67.4" "7.12" "17.38" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00515, Pf13181" "9868" "ENSG00000154174" "TOMM70" "D3DN48; hsa:9868; O94826" "Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Mitochondrial protein import; DDX58/IFIH1-mediated induction of interferon-alpha/beta; SARS-CoV-1 activates/modulates innate immune responses; PINK1-PRKN Mediated Mitophagy" "9" "0" "0.933" "0.977" "1.042" "1.036" "1.050" "0.913" "0.981" "0.977" "1.002" "1055.7" "984.5" "1031.8" "1100.2" "1094.2" "1108.2" "964.0" "1035.6" "1031.1" "1057.9" "" "" "" "" "" "" "" "" "" "" "989.2" "814.7" "957.9" "850.5" "932.7" "1058.8" "880.9" "919.5" "1031.1" "1018.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2714329419910624829" "False" "High" "IsMasterProtein" "P47985" "Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRFS1 PE=1 SV=2" "0.000" "False" "14.045" "19" "5" "6" "5" "274" "29.6" "8.32" "16.34" "5" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00355, Pf02921, Pf09165" "7386" "ENSG00000169021" "UQCRFS1" "A8K519; hsa:7386; P47985; Q6NVX5; Q9UPH2" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly; Iron metabolism disorders; Arsenic metabolism and reactive oxygen species generation" "Respiratory electron transport" "6" "0" "1.073" "0.934" "0.976" "1.159" "1.159" "1.062" "1.031" "1.010" "0.945" "193.6" "207.8" "180.8" "189.0" "224.4" "224.3" "205.7" "199.6" "195.5" "182.9" "" "" "" "" "" "" "" "" "" "" "181.4" "172.0" "167.9" "146.1" "191.3" "214.3" "187.9" "177.2" "195.5" "176.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8417235359346522376" "False" "High" "IsMasterProtein" "Q9NR12" "PDZ and LIM domain protein 7 OS=Homo sapiens OX=9606 GN=PDLIM7 PE=1 SV=1" "0.000" "False" "14.020" "10" "5" "5" "5" "457" "49.8" "8.41" "15.79" "5" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595" "9260" "ENSG00000196923" "PDLIM7" "hsa:9260; Q14250; Q5XG82; Q6NVZ5; Q96C91; Q9BXB8; Q9BXB9; Q9NR12" "Ebstein-Barr virus LMP1 signaling; GDNF signaling; 5q35 copy number variation" "RET signaling" "4" "0" "1.049" "0.997" "1.063" "0.998" "1.029" "1.045" "0.994" "0.988" "0.989" "694.1" "728.0" "692.3" "737.5" "692.7" "714.4" "725.2" "690.1" "685.5" "686.8" "" "" "" "" "" "" "" "" "" "" "650.3" "602.4" "642.7" "570.1" "590.4" "682.5" "662.7" "612.8" "685.5" "661.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "545176652009721876" "False" "High" "IsMasterProtein" "Q9P013" "Spliceosome-associated protein CWC15 homolog OS=Homo sapiens OX=9606 GN=CWC15 PE=1 SV=2" "0.000" "False" "14.017" "19" "5" "6" "5" "229" "26.6" "5.71" "18.68" "5" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf04889" "51503" "ENSG00000150316" "CWC15" "B2RC17; hsa:51503; Q05BV9; Q05DM1; Q9P013; Q9UI29" "" "mRNA Splicing - Major Pathway" "1" "0" "1.036" "1.024" "0.996" "1.042" "1.002" "1.223" "1.184" "1.120" "1.010" "1040.6" "1078.2" "1065.3" "1036.3" "1084.6" "1043.1" "1272.6" "1232.5" "1165.3" "1051.3" "" "" "" "" "" "" "" "" "" "" "975.0" "892.2" "989.0" "801.1" "924.5" "996.6" "1162.8" "1094.3" "1165.3" "1012.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1801357975470055423" "False" "High" "IsMasterProtein" "O14526" "F-BAR domain only protein 1 OS=Homo sapiens OX=9606 GN=FCHO1 PE=1 SV=2" "0.000" "False" "14.016" "5" "5" "5" "5" "889" "96.8" "6.96" "13.53" "5" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00611, Pf10291" "23149" "ENSG00000130475" "FCHO1" "A6NHE6; A8K5U5; B4E120; hsa:23149; O14526; Q05C93; Q8IW22" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "1.002" "0.991" "0.959" "1.029" "1.044" "0.953" "0.973" "1.004" "1.027" "426.4" "427.3" "422.8" "409.0" "438.6" "445.0" "406.6" "415.1" "428.1" "438.1" "" "" "" "" "" "" "" "" "" "" "399.6" "353.6" "392.5" "316.2" "373.9" "425.1" "371.5" "368.6" "428.1" "421.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8991968867262954800" "False" "High" "IsMasterProtein" "Q9P2K8" "eIF-2-alpha kinase GCN2 OS=Homo sapiens OX=9606 GN=EIF2AK4 PE=1 SV=3" "0.000" "False" "14.013" "3" "6" "6" "6" "1649" "186.8" "6.28" "13.52" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069, Pf05773, Pf12745, Pf13393" "440275" "ENSG00000128829" "EIF2AK4" "C9JEC4; hsa:440275; Q69YL7; Q6DC97; Q96GN6; Q9H5K1; Q9NSQ3; Q9NSZ5; Q9P2K8; Q9UJ56" "Measles virus infection" "Response of EIF2AK4 (GCN2) to amino acid deficiency" "2" "0" "1.003" "1.020" "0.937" "1.016" "1.002" "1.031" "0.995" "1.051" "0.982" "444.3" "445.7" "453.3" "416.1" "451.5" "445.3" "458.0" "442.0" "466.9" "436.4" "" "" "" "" "" "" "" "" "" "" "416.3" "368.8" "420.8" "321.7" "384.9" "425.4" "418.5" "392.4" "466.9" "420.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7228226931451830335" "False" "High" "IsMasterProtein" "O15084" "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Homo sapiens OX=9606 GN=ANKRD28 PE=1 SV=5" "0.000" "False" "13.997" "5" "5" "7" "3" "1053" "112.9" "6.25" "18.86" "5" "" "cytosol;nucleus" "" "Pf00023, Pf12796" "23243" "ENSG00000206560" "ANKRD28" "B4DES5; hsa:23243; O15084; Q1WWL4; Q29RW6; Q3B857; Q6ULS0; Q6ZT57" "" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "2" "0" "1.050" "0.951" "1.161" "0.968" "0.976" "0.999" "0.890" "0.842" "0.858" "160.4" "168.3" "152.6" "186.3" "155.2" "156.5" "160.2" "142.7" "135.1" "137.6" "" "" "" "" "" "" "" "" "" "" "150.3" "139.3" "141.6" "144.0" "132.3" "149.5" "146.4" "126.7" "135.1" "132.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1710541814749781042" "False" "High" "IsMasterProtein" "P54619" "5'-AMP-activated protein kinase subunit gamma-1 OS=Homo sapiens OX=9606 GN=PRKAG1 PE=1 SV=1" "0.000" "False" "13.990" "12" "4" "4" "4" "331" "37.6" "6.92" "14.29" "4" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00571" "5571" "ENSG00000181929" "PRKAG1" "B4DDT7; hsa:5571; P54619; Q8N7V9" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Angiopoietin-like protein 8 regulatory pathway; Leptin and adiponectin; Lipid metabolism pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Pleural mesothelioma" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy" "24" "0" "0.892" "1.048" "1.125" "1.067" "1.031" "1.062" "1.043" "0.985" "1.029" "342.2" "305.1" "358.7" "385.0" "365.1" "352.8" "363.4" "356.8" "337.0" "352.3" "" "" "" "" "" "" "" "" "" "" "320.6" "252.5" "333.0" "297.6" "311.2" "337.1" "332.0" "316.8" "337.0" "339.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6991992927110115551" "False" "High" "IsMasterProtein" "Q99504" "Eyes absent homolog 3 OS=Homo sapiens OX=9606 GN=EYA3 PE=1 SV=3" "0.000" "False" "13.988" "10" "5" "5" "5" "573" "62.6" "5.21" "16.53" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00702" "2140" "ENSG00000158161" "EYA3" "A8K190; B4DIR7; B4DNZ7; hsa:2140; O95463; Q8IVX7; Q99504; Q99813" "" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" "1" "0" "1.018" "0.987" "0.987" "1.061" "1.011" "1.023" "1.001" "0.994" "1.016" "688.7" "701.4" "679.5" "680.1" "731.0" "696.2" "704.3" "689.1" "684.3" "699.7" "" "" "" "" "" "" "" "" "" "" "645.3" "580.4" "630.8" "525.7" "623.1" "665.2" "643.5" "611.8" "684.3" "673.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2963377560695435167" "False" "High" "IsMasterProtein" "Q96P47" "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 OS=Homo sapiens OX=9606 GN=AGAP3 PE=1 SV=2" "0.000" "False" "13.981" "6" "4" "5" "4" "875" "95.0" "7.97" "15.80" "4" "protein metabolism;other metabolic processes;stress response" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00071, Pf01412, Pf12796" "116988" "ENSG00000133612" "AGAP3" "B3KNZ8; E9PAL8; hsa:116988; Q59EN0; Q96P47; Q96RK3" "" "" "0" "0" "0.967" "0.946" "1.000" "1.025" "0.953" "0.940" "1.010" "0.984" "0.948" "432.7" "418.4" "409.2" "432.6" "443.3" "412.4" "406.8" "437.2" "426.0" "410.3" "" "" "" "" "" "" "" "" "" "" "405.5" "346.2" "379.9" "334.4" "377.9" "394.0" "371.7" "388.2" "426.0" "395.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1978965257736533934" "False" "High" "IsMasterProtein" "Q9NYK5" "Large ribosomal subunit protein mL39 OS=Homo sapiens OX=9606 GN=MRPL39 PE=1 SV=3" "0.000" "False" "13.980" "14" "5" "7" "5" "338" "38.7" "7.65" "19.33" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "" "54148" "ENSG00000154719" "MRPL39" "C9JYA5; hsa:54148; Q32Q74; Q5QTR3; Q96Q65; Q9BSQ7; Q9BZV6; Q9NX44; Q9NYK5" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.021" "1.027" "1.018" "1.098" "1.164" "1.166" "1.133" "1.067" "1.098" "594.9" "607.5" "610.8" "605.4" "653.3" "692.3" "693.5" "674.0" "634.8" "653.5" "" "" "" "" "" "" "" "" "" "" "557.4" "502.7" "567.0" "468.0" "556.9" "661.4" "633.7" "598.4" "634.8" "629.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3175822401937946454" "False" "High" "IsMasterProtein" "Q15942" "Zyxin OS=Homo sapiens OX=9606 GN=ZYX PE=1 SV=1" "0.000" "False" "13.979" "10" "5" "7" "5" "572" "61.2" "6.67" "24.28" "5" "cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "7791" "ENSG00000159840; ENSG00000285443" "ZYX" "A4D2G6; B4DQX7; hsa:7791; Q15942; Q6I9S4" "Integrin-mediated cell adhesion; Focal adhesion" "" "2" "0" "1.002" "0.929" "0.969" "0.975" "0.965" "0.989" "1.040" "0.980" "0.963" "827.8" "829.6" "768.8" "802.4" "807.0" "798.6" "818.6" "860.7" "811.5" "797.5" "" "" "" "" "" "" "" "" "" "" "775.7" "686.5" "713.7" "620.3" "687.9" "763.0" "748.0" "764.2" "811.5" "767.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3895528791649615838" "False" "High" "IsMasterProtein" "Q86UE4" "Protein LYRIC OS=Homo sapiens OX=9606 GN=MTDH PE=1 SV=2" "0.000" "False" "13.974" "8" "4" "5" "4" "582" "63.8" "9.32" "19.97" "4" "signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15686" "92140" "ENSG00000147649" "MTDH" "hsa:92140; Q05DH2; Q52QU9; Q6PK07; Q86UE4; Q8TCX3" "Gastric cancer network 2; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; CCL18 signaling pathway" "" "3" "0" "1.028" "0.940" "1.114" "1.145" "1.040" "1.422" "1.515" "1.337" "1.135" "683.6" "702.9" "642.8" "761.6" "782.5" "710.9" "972.3" "1035.6" "914.1" "776.3" "" "" "" "" "" "" "" "" "" "" "640.6" "581.6" "596.8" "588.8" "667.0" "679.2" "888.5" "919.5" "914.1" "747.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2652497111054879184" "False" "High" "IsMasterProtein" "Q96HE7" "ERO1-like protein alpha OS=Homo sapiens OX=9606 GN=ERO1A PE=1 SV=2" "0.000" "False" "13.974" "10" "4" "5" "4" "468" "54.4" "5.68" "17.18" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf04137" "30001" "ENSG00000197930" "ERO1A" "A8K9X4; A8MYW1; hsa:30001; Q7LD45; Q96HE7; Q9P1Q9; Q9UKV6" "" "Detoxification of Reactive Oxygen Species" "1" "0" "0.925" "0.984" "0.920" "0.965" "0.968" "0.987" "0.928" "0.936" "0.939" "801.1" "741.5" "788.6" "736.8" "773.4" "775.6" "790.4" "743.6" "749.5" "752.0" "" "" "" "" "" "" "" "" "" "" "750.7" "613.5" "732.2" "569.6" "659.2" "741.0" "722.3" "660.2" "749.5" "724.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-81494833362564834" "False" "High" "IsMasterProtein" "Q8WVJ2" "NudC domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NUDCD2 PE=1 SV=1" "0.000" "False" "13.971" "24" "3" "4" "3" "157" "17.7" "5.07" "14.70" "3" "protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf04969" "134492" "ENSG00000170584" "NUDCD2" "B2R4V0; hsa:134492; Q8WVJ2" "" "" "0" "0" "1.004" "0.934" "0.883" "0.998" "0.946" "0.966" "0.943" "0.945" "0.922" "664.8" "667.7" "620.7" "587.3" "663.3" "629.0" "642.2" "626.9" "628.3" "613.2" "" "" "" "" "" "" "" "" "" "" "622.9" "552.5" "576.2" "454.0" "565.4" "600.9" "586.8" "556.7" "628.3" "590.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1845643412684317790" "False" "High" "IsMasterProtein" "P49674" "Casein kinase I isoform epsilon OS=Homo sapiens OX=9606 GN=CSNK1E PE=1 SV=1" "0.000" "False" "13.963" "14" "5" "5" "5" "416" "47.3" "9.66" "16.34" "5" "cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "102800317; 1454" "ENSG00000213923" "CSNK1E" "hsa:102800317; hsa:1454; P49674" "Alzheimer's disease and miRNA effects; Melatonin metabolism and effects; Wnt signaling pathway; Wnt signaling pathway and pluripotency; Hedgehog signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma; Alzheimer's disease" "Major pathway of rRNA processing in the nucleolus and cytosol; WNT mediated activation of DVL; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Circadian Clock" "20" "0" "0.882" "0.903" "0.873" "0.952" "0.946" "0.794" "0.908" "0.861" "0.806" "612.1" "539.6" "552.9" "534.4" "582.6" "579.1" "485.9" "555.8" "527.1" "493.5" "" "" "" "" "" "" "" "" "" "" "573.5" "446.5" "513.3" "413.1" "496.6" "553.3" "444.0" "493.5" "527.1" "475.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7506213950327089282" "False" "High" "IsMasterProtein" "Q8IUF8" "Ribosomal oxygenase 2 OS=Homo sapiens OX=9606 GN=RIOX2 PE=1 SV=1" "0.000" "False" "13.939" "11" "5" "8" "5" "465" "52.8" "6.70" "24.33" "5" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08007, Pf20514" "84864" "ENSG00000170854" "RIOX2" "D3DN35; Q6AHW4; Q6SKS0; Q8IU69; Q8IUF6; Q8IUF7; Q8IUF8; Q96C17; Q96KB0" "" "Protein hydroxylation; HDMs demethylate histones" "2" "0" "0.919" "0.995" "0.928" "0.965" "0.948" "1.002" "0.962" "0.993" "1.027" "1469.0" "1349.4" "1461.7" "1363.9" "1418.2" "1393.0" "1472.0" "1412.5" "1458.8" "1509.3" "" "" "" "" "" "" "" "" "" "" "1376.4" "1116.6" "1357.0" "1054.4" "1208.8" "1330.8" "1345.0" "1254.1" "1458.8" "1453.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7103280702382610433" "False" "High" "IsMasterProtein" "Q8IX90" "Spindle and kinetochore-associated protein 3 OS=Homo sapiens OX=9606 GN=SKA3 PE=1 SV=2" "0.000" "False" "13.934" "7" "3" "4" "3" "412" "46.3" "5.11" "13.21" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "" "221150" "ENSG00000165480" "SKA3" "A2A330; A2A331; B2RBY2; hsa:221150; Q5VZV5; Q86WR2; Q8IX90; Q8NBG1; Q96D22" "" "" "0" "0" "1.032" "0.901" "1.043" "1.059" "1.073" "0.936" "0.915" "0.944" "1.021" "427.4" "440.9" "385.1" "445.8" "452.6" "458.8" "400.1" "391.1" "403.3" "436.3" "" "" "" "" "" "" "" "" "" "" "400.5" "364.8" "357.5" "344.6" "385.8" "438.3" "365.6" "347.2" "403.3" "420.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1136415192925944721" "False" "High" "IsMasterProtein" "Q04864" "Proto-oncogene c-Rel OS=Homo sapiens OX=9606 GN=REL PE=1 SV=1" "0.000" "False" "13.927" "9" "5" "8" "5" "619" "68.5" "5.86" "25.26" "5" "stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "5966" "ENSG00000162924" "REL" "hsa:5966; Q04864; Q17RU2; Q2PNZ7; Q6LDY0" "IL-1 signaling pathway; Leptin signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Photodynamic therapy-induced NF-kB survival signaling; Toll-like receptor signaling related to MyD88; Fibrin complement receptor 3 signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; miRNA role in immune response in sepsis; Canonical NF-kB pathway; Head and neck squamous cell carcinoma; IL-18 signaling pathway; 16p11.2 proximal deletion syndrome; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; Interferon type I signaling pathways; T-cell receptor signaling pathway" "Activation of NF-kappaB in B cells" "20" "0" "1.011" "0.988" "1.025" "1.101" "1.051" "1.049" "1.003" "1.014" "1.035" "408.8" "413.5" "403.7" "418.9" "450.2" "429.6" "428.9" "410.1" "414.5" "423.2" "" "" "" "" "" "" "" "" "" "" "383.1" "342.2" "374.8" "323.8" "383.8" "410.5" "391.9" "364.1" "414.5" "407.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "247879969936268411" "False" "High" "IsMasterProtein" "O94992" "Protein HEXIM1 OS=Homo sapiens OX=9606 GN=HEXIM1 PE=1 SV=1" "0.000" "False" "13.904" "12" "5" "11" "4" "359" "40.6" "4.89" "28.05" "5" "stress response;developmental processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf15313" "10614" "ENSG00000186834" "HEXIM1" "B2R8Y5; hsa:10614; O94992" "Initiation of transcription and translation elongation at the HIV-1 LTR" "" "1" "1" "1.064" "1.011" "1.080" "1.050" "1.044" "1.066" "1.073" "1.034" "1.037" "1031.7" "1097.9" "1043.1" "1114.4" "1083.7" "1076.8" "1099.8" "1106.7" "1066.5" "1069.8" "" "" "" "" "" "" "" "" "" "" "966.7" "908.5" "968.4" "861.5" "923.7" "1028.7" "1004.9" "982.6" "1066.5" "1030.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8148433569690540229" "False" "High" "IsMasterProtein" "Q96C36" "Pyrroline-5-carboxylate reductase 2 OS=Homo sapiens OX=9606 GN=PYCR2 PE=1 SV=1" "0.000" "False" "13.880" "13" "3" "5" "3" "320" "33.6" "7.77" "15.16" "3" "other metabolic processes;stress response" "mitochondrion" "other molecular function" "Pf03807, Pf14748" "29920" "ENSG00000143811" "PYCR2" "A8K798; hsa:29920; Q7Z515; Q96C36; Q9Y5J4" "Metabolic reprogramming in colon cancer" "Glutamate and glutamine metabolism" "2" "0" "1.012" "1.064" "1.016" "1.065" "0.992" "1.006" "1.001" "1.023" "1.041" "360.7" "364.9" "383.8" "366.7" "384.1" "357.8" "362.9" "361.0" "369.2" "375.5" "" "" "" "" "" "" "" "" "" "" "338.0" "302.0" "356.3" "283.5" "327.4" "341.8" "331.6" "320.5" "369.2" "361.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1234088544826657040" "False" "High" "IsMasterProtein" "Q9H871" "E3 ubiquitin-protein transferase RMND5A OS=Homo sapiens OX=9606 GN=RMND5A PE=1 SV=1" "0.000" "False" "13.877" "9" "4" "5" "4" "391" "44.0" "6.06" "11.78" "4" "protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf10607, Pf13445" "64795" "ENSG00000153561" "RMND5A" "D6W5M6; hsa:64795; Q6NTF0; Q9H6W5; Q9H871; Q9H9H2" "Ciliary landscape" "" "1" "0" "0.967" "1.069" "0.942" "1.045" "1.109" "0.946" "1.075" "1.069" "1.094" "404.9" "391.3" "432.8" "381.4" "423.0" "448.9" "383.0" "435.1" "432.6" "442.8" "" "" "" "" "" "" "" "" "" "" "379.3" "323.8" "401.8" "294.9" "360.6" "428.9" "350.0" "386.3" "432.6" "426.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3173318319984318675" "False" "High" "IsMasterProtein" "Q9BXR0" "Queuine tRNA-ribosyltransferase catalytic subunit 1 OS=Homo sapiens OX=9606 GN=QTRT1 PE=1 SV=3" "0.000" "False" "13.874" "10" "4" "6" "4" "403" "44.0" "7.23" "26.31" "4" "RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01702" "81890" "ENSG00000213339" "QTRT1" "B4DFM7; hsa:81890; Q96BQ4; Q9BXQ9; Q9BXR0" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.995" "1.017" "1.076" "1.064" "1.005" "1.098" "1.061" "1.033" "1.014" "615.8" "612.8" "626.4" "662.4" "655.2" "618.7" "676.1" "653.5" "636.0" "624.4" "" "" "" "" "" "" "" "" "" "" "577.0" "507.1" "581.5" "512.1" "558.5" "591.1" "617.8" "580.2" "636.0" "601.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1824011876683044668" "False" "High" "IsMasterProtein" "Q9ULA0" "Aspartyl aminopeptidase OS=Homo sapiens OX=9606 GN=DNPEP PE=1 SV=2" "0.000" "False" "13.869" "11" "5" "7" "5" "485" "53.4" "7.58" "23.82" "5" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02127" "23549" "ENSG00000123992" "DNPEP" "hsa:23549; Q9BW44; Q9NUV5; Q9NV55; Q9ULA0" "Ciliary landscape" "" "1" "0" "1.008" "0.977" "0.949" "0.948" "0.968" "0.990" "0.938" "0.959" "0.945" "1175.3" "1184.3" "1147.8" "1115.3" "1114.2" "1138.0" "1163.9" "1101.9" "1127.0" "1111.1" "" "" "" "" "" "" "" "" "" "" "1101.3" "980.0" "1065.6" "862.2" "949.7" "1087.2" "1063.5" "978.4" "1127.0" "1069.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "51923672491572090" "False" "High" "IsMasterProtein" "Q4J6C6" "Prolyl endopeptidase-like OS=Homo sapiens OX=9606 GN=PREPL PE=1 SV=1" "0.000" "False" "13.849" "6" "5" "6" "5" "727" "83.9" "6.38" "16.72" "5" "protein metabolism;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus" "other molecular function" "Pf00326, Pf02897" "9581" "ENSG00000138078" "PREPL" "A7E2X6; D6W5A3; hsa:9581; O43163; Q4J6C3; Q4J6C4; Q4J6C6; Q4ZG39; Q6ZMW7; Q96DW7" "Primary ovarian insufficiency" "" "1" "0" "0.955" "0.959" "0.984" "0.921" "1.010" "0.911" "0.901" "0.965" "0.999" "1004.5" "958.8" "963.7" "988.6" "925.5" "1014.3" "915.3" "905.3" "969.3" "1003.5" "" "" "" "" "" "" "" "" "" "" "941.2" "793.4" "894.7" "764.3" "788.9" "969.1" "836.3" "803.8" "969.3" "966.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1789067979643489698" "False" "High" "IsMasterProtein" "P46976" "Glycogenin-1 OS=Homo sapiens OX=9606 GN=GYG1 PE=1 SV=4" "0.000" "False" "13.818" "14" "5" "7" "5" "350" "39.4" "5.53" "20.14" "5" "other metabolic processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01501" "2992" "ENSG00000163754" "GYG1" "D3DNH0; D3DNH1; D3DNH2; hsa:2992; P46976; Q6FHZ1; Q9UNV0" "Insulin signaling; Glycogen synthesis and degradation; Disorders of galactose metabolism" "Neutrophil degranulation; Glycogen synthesis; Glycogen breakdown (glycogenolysis); Myoclonic epilepsy of Lafora; Glycogen storage disease type II (GAA); Glycogen storage disease type XV (GYG1); Glycogen storage disease type 0 (muscle GYS1)" "10" "0" "1.044" "1.091" "1.138" "1.149" "1.067" "1.210" "1.302" "1.019" "1.115" "87.8" "91.6" "95.8" "99.9" "100.9" "93.6" "106.2" "114.3" "89.4" "97.9" "" "" "" "" "" "" "" "" "" "" "82.2" "75.8" "88.9" "77.2" "86.0" "89.4" "97.1" "101.5" "89.4" "94.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2463119363191037669" "False" "High" "IsMasterProtein" "Q66LE6" "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform OS=Homo sapiens OX=9606 GN=PPP2R2D PE=1 SV=1" "0.000" "False" "13.815" "7" "3" "4" "1" "453" "52.0" "6.39" "15.93" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "" "55844" "ENSG00000175470" "PPP2R2D" "A8KAK0; hsa:55844; Q5SQJ2; Q66LE6; Q9P1Y7" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "MASTL Facilitates Mitotic Progression" "3" "0" "0.993" "0.959" "1.138" "1.037" "1.014" "0.949" "0.905" "0.908" "0.953" "138.3" "137.3" "132.7" "157.4" "143.5" "140.2" "131.2" "125.1" "125.5" "131.8" "" "" "" "" "" "" "" "" "" "" "129.6" "113.6" "123.2" "121.7" "122.3" "134.0" "119.9" "111.1" "125.5" "126.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8651135355279393622" "False" "High" "IsMasterProtein" "Q8N2G8" "GH3 domain-containing protein OS=Homo sapiens OX=9606 GN=GHDC PE=1 SV=2" "0.000" "False" "13.802" "10" "5" "6" "5" "530" "57.5" "7.88" "14.20" "5" "" "non-structural extracellular;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03321" "84514" "ENSG00000167925" "GHDC" "B4DQS4; E9PDB5; hsa:84514; Q8N2G8; Q9BXM6" "" "Neutrophil degranulation" "1" "0" "1.046" "1.065" "1.110" "1.132" "1.068" "0.984" "0.968" "1.021" "1.051" "430.6" "450.5" "458.7" "478.0" "487.5" "459.8" "423.7" "417.0" "439.8" "452.6" "" "" "" "" "" "" "" "" "" "" "403.5" "372.8" "425.9" "369.5" "415.5" "439.3" "387.1" "370.2" "439.8" "435.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2996634066211424368" "False" "High" "IsMasterProtein" "Q92994" "Transcription factor IIIB 90 kDa subunit OS=Homo sapiens OX=9606 GN=BRF1 PE=1 SV=1" "0.000" "False" "13.789" "8" "5" "6" "5" "677" "73.8" "5.43" "18.30" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00382, Pf07741, Pf08271" "2972" "ENSG00000185024" "BRF1" "B3KU36; B4DIG5; B7Z2N3; F5H5Z7; F8WA46; hsa:2972; Q13223; Q3SYD9; Q5PR24; Q6IQ02; Q92994; Q96KX3; Q9HCW6; Q9HCW7; Q9HCW8" "TAR syndrome" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "4" "0" "1.036" "1.073" "1.024" "1.130" "1.090" "0.973" "0.984" "1.047" "1.078" "197.3" "204.4" "211.7" "201.9" "223.0" "215.0" "192.0" "194.1" "206.5" "212.6" "" "" "" "" "" "" "" "" "" "" "184.8" "169.1" "196.5" "156.1" "190.1" "205.4" "175.4" "172.3" "206.5" "204.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6145009283245857027" "False" "High" "IsMasterProtein" "P62487" "DNA-directed RNA polymerase II subunit RPB7 OS=Homo sapiens OX=9606 GN=POLR2G PE=1 SV=1" "0.000" "False" "13.786" "28" "4" "5" "4" "172" "19.3" "5.54" "14.11" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00575, Pf03876" "5436" "ENSG00000168002" "POLR2G" "B2R5C0; hsa:5436; P52433; P62487; Q2M1Z4" "Pyrimidine metabolism; Eukaryotic transcription initiation" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "43" "0" "0.925" "0.993" "0.905" "0.994" "1.058" "0.971" "1.028" "1.102" "1.011" "368.5" "340.9" "365.8" "333.3" "366.3" "390.0" "357.8" "378.8" "406.2" "372.5" "" "" "" "" "" "" "" "" "" "" "345.3" "282.1" "339.6" "257.7" "312.2" "372.6" "327.0" "336.4" "406.2" "358.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5304133680658965036" "False" "High" "IsMasterProtein" "Q16629" "Serine/arginine-rich splicing factor 7 OS=Homo sapiens OX=9606 GN=SRSF7 PE=1 SV=1" "0.000" "False" "13.780" "18" "5" "6" "5" "238" "27.4" "11.82" "16.65" "5" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6432" "ENSG00000115875" "SRSF7" "B4DLU6; G5E9M3; hsa:6432; Q16629; Q564D3" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "7" "0" "1.088" "1.040" "0.946" "0.885" "0.899" "0.899" "0.785" "0.883" "0.960" "537.7" "585.0" "559.1" "508.8" "475.8" "483.3" "483.4" "422.2" "475.0" "516.5" "" "" "" "" "" "" "" "" "" "" "503.8" "484.0" "519.0" "393.3" "405.6" "461.7" "441.7" "374.9" "475.0" "497.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4549685978582378632" "False" "High" "IsMasterProtein" "Q9Y399" "Small ribosomal subunit protein uS2m OS=Homo sapiens OX=9606 GN=MRPS2 PE=1 SV=1" "0.000" "False" "13.779" "18" "6" "7" "6" "296" "33.2" "9.26" "19.75" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00318" "51116" "ENSG00000122140" "MRPS2" "hsa:51116; Q5T899; Q9BSQ4; Q9Y399" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination; Mitochondrial protein degradation" "4" "0" "0.996" "1.068" "1.053" "1.094" "1.081" "0.988" "0.950" "0.958" "1.031" "500.2" "498.2" "534.0" "526.8" "547.1" "540.9" "494.3" "474.9" "479.0" "515.7" "" "" "" "" "" "" "" "" "" "" "468.7" "412.3" "495.8" "407.2" "466.3" "516.7" "451.7" "421.7" "479.0" "496.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1176718520801112015" "False" "High" "IsMasterProtein" "P11441" "Ubiquitin-like protein 4A OS=Homo sapiens OX=9606 GN=UBL4A PE=1 SV=1" "0.000" "False" "13.776" "22" "4" "5" "4" "157" "17.8" "8.66" "15.57" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf17840" "8266" "ENSG00000102178" "UBL4A" "hsa:8266; P11441; Q5HY80" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "1.053" "0.901" "1.068" "1.008" "0.939" "1.045" "1.019" "0.983" "0.986" "758.0" "798.3" "683.0" "809.3" "763.7" "711.9" "792.0" "772.6" "745.3" "747.6" "" "" "" "" "" "" "" "" "" "" "710.2" "660.6" "634.1" "625.6" "651.0" "680.2" "723.7" "686.0" "745.3" "719.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7061207721996529093" "False" "High" "IsMasterProtein" "P08758" "Annexin A5 OS=Homo sapiens OX=9606 GN=ANXA5 PE=1 SV=2" "0.000" "False" "13.771" "17" "6" "8" "5" "320" "35.9" "5.05" "16.50" "6" "stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00191" "308" "ENSG00000164111" "ANXA5" "D3DNW7; hsa:308; P08758; Q6FHB3; Q6FI16; Q8WV69; Q9UDH9" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Interactions between LOXL4 and oxidative stress pathway; Prostaglandin synthesis and regulation" "Platelet degranulation" "4" "0" "0.974" "0.963" "0.876" "0.951" "1.085" "0.927" "0.907" "0.949" "1.025" "459.6" "447.7" "442.8" "402.6" "436.9" "498.9" "426.1" "416.9" "436.1" "471.3" "" "" "" "" "" "" "" "" "" "" "430.7" "370.5" "411.1" "311.2" "372.4" "476.6" "389.3" "370.1" "436.1" "453.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "172314789071643693" "False" "High" "IsMasterProtein" "Q8IWV7" "E3 ubiquitin-protein ligase UBR1 OS=Homo sapiens OX=9606 GN=UBR1 PE=1 SV=1" "0.000" "False" "13.768" "3" "5" "5" "5" "1749" "200.1" "6.01" "15.23" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf02207, Pf02617, Pf18995" "197131" "ENSG00000159459" "UBR1" "O60708; O75492; Q14D45; Q68DN9; Q8IWV7; Q8IWY6; Q96JY4" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.095" "0.949" "1.052" "1.059" "1.029" "1.152" "1.011" "0.976" "1.001" "147.5" "161.6" "139.9" "155.2" "156.2" "151.8" "169.9" "149.2" "143.9" "147.7" "" "" "" "" "" "" "" "" "" "" "138.2" "133.7" "129.9" "120.0" "133.1" "145.1" "155.3" "132.5" "143.9" "142.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9167076474534668157" "False" "High" "IsMasterProtein" "Q15398" "Disks large-associated protein 5 OS=Homo sapiens OX=9606 GN=DLGAP5 PE=1 SV=2" "0.000" "False" "13.767" "6" "6" "6" "6" "846" "95.1" "9.00" "17.11" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf03359" "9787" "ENSG00000126787" "DLGAP5" "A8MTM6; B4DRM8; hsa:9787; Q15398; Q86T11; Q8NG58" "Complement system in neuronal development and plasticity" "NOTCH3 Intracellular Domain Regulates Transcription" "2" "0" "1.002" "0.979" "0.980" "1.008" "0.955" "0.931" "0.941" "0.925" "1.008" "672.6" "674.3" "658.2" "659.3" "678.1" "642.5" "626.4" "632.8" "622.0" "678.3" "" "" "" "" "" "" "" "" "" "" "630.3" "558.0" "611.1" "509.7" "578.0" "613.9" "572.3" "561.9" "622.0" "653.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6091940501454683011" "False" "High" "IsMasterProtein" "Q9UNX4" "WD repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=WDR3 PE=1 SV=1" "0.000" "False" "13.766" "4" "5" "5" "5" "943" "106.0" "6.64" "15.53" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf00400, Pf04003, Pf12894" "10885" "ENSG00000065183" "WDR3" "hsa:10885; Q9UNX4" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.219" "1.170" "1.298" "1.209" "1.101" "1.311" "1.317" "1.334" "1.186" "395.2" "481.9" "462.6" "512.9" "478.0" "435.2" "518.0" "520.4" "527.1" "468.6" "" "" "" "" "" "" "" "" "" "" "370.3" "398.7" "429.5" "396.5" "407.4" "415.8" "473.4" "462.1" "527.1" "451.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4874402221689570626" "False" "High" "IsMasterProtein" "Q86W56" "Poly(ADP-ribose) glycohydrolase OS=Homo sapiens OX=9606 GN=PARG PE=1 SV=1" "0.000" "False" "13.761" "5" "5" "6" "5" "976" "111.0" "6.43" "17.09" "5" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf05028, Pf20811" "670; 8505" "ENSG00000227345" "PARG" "A5YBK3; B2RC24; B4DIU5; B4DYR4; hsa:8505; I6RUV3; Q6E4P6; Q6E4P7; Q7Z742; Q86W56; Q9Y4W7" "10q11.21q11.23 copy number variation syndrome" "POLB-Dependent Long Patch Base Excision Repair" "2" "0" "1.112" "1.089" "1.062" "1.049" "1.097" "1.116" "0.988" "1.070" "1.054" "228.5" "254.1" "248.9" "242.6" "239.7" "250.7" "255.1" "225.7" "244.5" "240.8" "" "" "" "" "" "" "" "" "" "" "214.1" "210.3" "231.1" "187.6" "204.3" "239.5" "233.0" "200.4" "244.5" "231.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1538784976841218653" "False" "High" "IsMasterProtein" "Q8N5C6" "S1 RNA-binding domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SRBD1 PE=1 SV=2" "0.000" "False" "13.760" "5" "6" "6" "5" "995" "111.7" "8.72" "15.28" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf00575, Pf09371, Pf12836, Pf16921, Pf17674" "55133" "ENSG00000068784" "SRBD1" "hsa:55133; Q53T56; Q8N5C6; Q96TA4; Q9NW11" "" "" "0" "1" "1.096" "1.084" "1.136" "1.108" "1.125" "1.122" "1.006" "1.103" "1.070" "604.7" "662.7" "655.5" "686.7" "670.2" "680.3" "678.7" "608.4" "667.2" "646.8" "" "" "" "" "" "" "" "" "" "" "566.6" "548.4" "608.5" "530.8" "571.3" "649.9" "620.2" "540.2" "667.2" "622.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2347983332977388865" "False" "High" "IsMasterProtein" "Q9H900" "Protein zwilch homolog OS=Homo sapiens OX=9606 GN=ZWILCH PE=1 SV=2" "0.000" "False" "13.759" "7" "5" "6" "5" "591" "67.2" "6.27" "18.52" "5" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf09817" "55055" "ENSG00000174442" "ZWILCH" "B3KVB8; hsa:55055; Q6N049; Q8N404; Q96SY7; Q9H900; Q9NWG7" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.952" "0.993" "1.011" "1.019" "1.030" "0.984" "0.999" "1.045" "1.029" "331.7" "315.8" "329.5" "335.3" "337.8" "341.5" "326.3" "331.2" "346.6" "341.2" "" "" "" "" "" "" "" "" "" "" "310.8" "261.4" "305.9" "259.2" "288.0" "326.3" "298.2" "294.1" "346.6" "328.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3764850706603646464" "False" "High" "IsMasterProtein" "Q9ULC4" "Malignant T-cell-amplified sequence 1 OS=Homo sapiens OX=9606 GN=MCTS1 PE=1 SV=1" "0.000" "False" "13.755" "22" "4" "7" "2" "181" "20.5" "8.82" "16.53" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other cell component" "nucleic acid binding activity" "Pf01472, Pf17832" "28985" "ENSG00000232119" "MCTS1" "B4DGY2; hsa:28985; Q502X6; Q9ULC4" "" "" "0" "2" "0.941" "0.958" "0.931" "0.932" "0.990" "0.901" "0.915" "1.157" "0.935" "753.2" "708.5" "721.4" "701.4" "702.2" "745.6" "678.9" "688.9" "871.8" "704.3" "" "" "" "" "" "" "" "" "" "" "705.8" "586.3" "669.7" "542.2" "598.5" "712.4" "620.4" "611.6" "871.8" "678.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8547587141624532923" "False" "High" "IsMasterProtein" "Q9UKV8" "Protein argonaute-2 OS=Homo sapiens OX=9606 GN=AGO2 PE=1 SV=3" "0.000" "False" "13.747" "7" "6" "8" "4" "859" "97.1" "9.19" "18.92" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02170, Pf02171, Pf08699, Pf16486, Pf16487, Pf16488" "27161" "ENSG00000123908" "AGO2" "Q8TCZ5; Q8WV58; Q96ID1; Q9UKV8" "exRNA mechanism of action and biogenesis; Fragile X syndrome; Male infertility; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "MAPK6/MAPK4 signaling; Transcriptional regulation by small RNAs; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; M-decay: degradation of maternal mRNAs by maternally stored factors; TP53 Regulates Metabolic Genes; Ca2+ pathway; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis; Nuclear events stimulated by ALK signaling in cancer; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "24" "1" "1.002" "0.958" "1.004" "0.989" "1.013" "1.014" "1.018" "1.027" "0.990" "599.1" "600.2" "574.0" "601.3" "592.3" "606.8" "607.3" "609.8" "615.5" "593.4" "" "" "" "" "" "" "" "" "" "" "561.4" "496.7" "532.9" "464.8" "504.9" "579.7" "554.9" "541.5" "615.5" "571.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-597243898993742241" "False" "High" "IsMasterProtein" "P17096" "High mobility group protein HMG-I/HMG-Y OS=Homo sapiens OX=9606 GN=HMGA1 PE=1 SV=3" "0.000" "False" "13.745" "36" "4" "13" "4" "107" "11.7" "10.32" "39.19" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "" "3159" "ENSG00000137309" "HMGA1" "hsa:3159; P10910; P17096; Q5T6U9; Q9UKB0" "Adipogenesis; Pre-implantation embryo; Male infertility; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Orexin receptor pathway" "Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "13" "0" "0.991" "0.975" "1.018" "1.047" "1.018" "1.079" "1.117" "1.001" "0.947" "1439.2" "1426.9" "1402.9" "1465.3" "1506.8" "1464.9" "1553.2" "1607.4" "1440.9" "1363.4" "" "" "" "" "" "" "" "" "" "" "1348.5" "1180.7" "1302.4" "1132.8" "1284.4" "1399.6" "1419.3" "1427.2" "1440.9" "1312.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5215276665585730267" "False" "High" "IsMasterProtein" "Q9BTD8" "RNA-binding protein 42 OS=Homo sapiens OX=9606 GN=RBM42 PE=1 SV=1" "0.000" "False" "13.735" "9" "4" "5" "4" "480" "50.4" "9.63" "14.67" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "79171" "ENSG00000126254" "RBM42" "hsa:79171; O00320; Q8N5R7; Q9BTD8; Q9BU66" "" "mRNA Splicing - Major Pathway" "1" "0" "1.113" "1.105" "1.057" "1.025" "1.104" "1.002" "1.079" "1.106" "1.044" "302.7" "336.9" "334.4" "319.8" "310.3" "334.2" "303.3" "326.6" "334.8" "315.9" "" "" "" "" "" "" "" "" "" "" "283.6" "278.8" "310.4" "247.2" "264.5" "319.3" "277.1" "290.0" "334.8" "304.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6072091565905259276" "False" "High" "IsMasterProtein" "P42574" "Caspase-3 OS=Homo sapiens OX=9606 GN=CASP3 PE=1 SV=2" "0.000" "False" "13.735" "17" "4" "5" "3" "277" "31.6" "6.54" "18.58" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00656" "836" "ENSG00000164305" "CASP3" "A8K5M2; D3DP53; hsa:836; P42574; Q96AN1; Q96KP2" "miRNA regulation of DNA damage response; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft rejection; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Copper homeostasis; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; ERK pathway in Huntington's disease; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Prion disease pathway; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; MTHFR deficiency; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; Complement system in neuronal development and plasticity; Orexin receptor pathway; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Urotensin-II-mediated signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; IL-26 signaling pathways; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response" "Caspase-mediated cleavage of cytoskeletal proteins; Degradation of the extracellular matrix; Apoptosis induced DNA fragmentation; Signaling by Hippo; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Caspase activation via Dependence Receptors in the absence of ligand; Pyroptosis; NADE modulates death signalling; Other interleukin signaling; Apoptotic cleavage of cell adhesion proteins; Stimulation of the cell death response by PAK-2p34" "60" "0" "0.908" "0.920" "0.934" "0.926" "0.978" "0.909" "0.917" "0.856" "0.867" "361.4" "328.3" "332.4" "337.4" "334.8" "353.4" "328.5" "331.5" "309.4" "313.3" "" "" "" "" "" "" "" "" "" "" "338.7" "271.6" "308.6" "260.9" "285.4" "337.6" "300.1" "294.3" "309.4" "301.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7273003467290879098" "False" "High" "IsMasterProtein" "Q9UNE7" "E3 ubiquitin-protein ligase CHIP OS=Homo sapiens OX=9606 GN=STUB1 PE=1 SV=2" "0.000" "False" "13.734" "13" "4" "6" "4" "303" "34.8" "5.87" "13.47" "4" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf04564, Pf12895, Pf18391" "10273" "ENSG00000103266" "STUB1" "A2IDB9; O60526; Q969U2; Q9HBT1; Q9UNE7" "Androgen receptor signaling pathway; Parkin-ubiquitin proteasomal system pathway; HDAC6 interactions in the central nervous system" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of TNFR1 signaling; Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Downregulation of TGF-beta receptor signaling" "11" "0" "1.045" "1.007" "0.983" "1.053" "1.018" "0.941" "0.987" "0.977" "1.006" "772.0" "807.2" "777.3" "758.9" "813.1" "785.9" "726.2" "761.9" "753.9" "776.8" "" "" "" "" "" "" "" "" "" "" "723.4" "667.9" "721.6" "586.7" "693.1" "750.8" "663.5" "676.5" "753.9" "748.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2502404100025205194" "False" "High" "IsMasterProtein" "P27824" "Calnexin OS=Homo sapiens OX=9606 GN=CANX PE=1 SV=2" "0.000" "False" "13.733" "10" "5" "5" "5" "592" "67.5" "4.60" "19.55" "5" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00262" "821" "ENSG00000127022; ENSG00000283777" "CANX" "B2R5V8; B4DGP8; B4E2T8; D3DWQ3; D6R9K3; hsa:821; P27824" "15q11q13 copy number variation" "MHC class II antigen presentation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Interleukin-35 Signalling; Interleukin-27 signaling; Assembly of Viral Components at the Budding Site; Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "9" "0" "0.981" "1.066" "0.949" "1.063" "1.142" "1.007" "1.097" "1.113" "1.118" "934.3" "916.9" "995.6" "887.0" "993.1" "1066.5" "940.7" "1024.6" "1039.4" "1044.5" "" "" "" "" "" "" "" "" "" "" "875.4" "758.8" "924.3" "685.7" "846.5" "1018.9" "859.5" "909.7" "1039.4" "1005.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7849372490440627698" "False" "High" "IsMasterProtein" "Q96P16" "Regulation of nuclear pre-mRNA domain-containing protein 1A OS=Homo sapiens OX=9606 GN=RPRD1A PE=1 SV=1" "0.000" "False" "13.720" "17" "5" "7" "5" "312" "35.7" "7.55" "22.89" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04818, Pf16566" "55197" "ENSG00000141425" "RPRD1A" "A8KA42; B2RBA3; hsa:55197; Q7Z5G8; Q96FY9; Q96P16; Q9NVL4" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "0.994" "0.914" "1.010" "1.005" "1.003" "1.260" "0.984" "0.977" "0.999" "648.8" "644.6" "592.7" "655.5" "651.9" "650.6" "817.8" "638.2" "633.6" "648.1" "" "" "" "" "" "" "" "" "" "" "607.9" "533.4" "550.2" "506.7" "555.6" "621.6" "747.2" "566.7" "633.6" "624.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7543040224215837261" "False" "High" "IsMasterProtein" "Q96EY4" "Translation machinery-associated protein 16 OS=Homo sapiens OX=9606 GN=TMA16 PE=1 SV=2" "0.000" "False" "13.720" "23" "5" "6" "5" "203" "23.8" "9.26" "19.59" "5" "other biological processes" "nucleus" "other molecular function" "Pf11176" "55319" "ENSG00000198498" "TMA16" "hsa:55319; Q0P6E4; Q0P6J1; Q96EY4; Q9NUR7" "" "" "0" "0" "1.023" "1.085" "1.015" "1.109" "1.186" "1.168" "1.298" "1.135" "1.052" "273.9" "280.3" "297.0" "278.0" "303.8" "324.8" "319.8" "355.6" "310.8" "288.1" "" "" "" "" "" "" "" "" "" "" "256.6" "231.9" "275.7" "214.9" "258.9" "310.3" "292.2" "315.7" "310.8" "277.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1368746537246451603" "False" "High" "IsMasterProtein" "Q9Y2I8" "WD repeat-containing protein 37 OS=Homo sapiens OX=9606 GN=WDR37 PE=1 SV=2" "0.000" "False" "13.716" "10" "5" "5" "5" "494" "54.6" "7.23" "15.97" "5" "developmental processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "22884" "ENSG00000047056" "WDR37" "A8K976; D3DRQ7; hsa:22884; Q5SW03; Q8WVG2; Q9NTJ6; Q9Y2I8" "" "" "0" "0" "0.948" "0.999" "1.006" "0.981" "1.009" "0.955" "0.957" "0.956" "0.972" "841.2" "797.6" "840.5" "845.8" "825.1" "849.0" "803.2" "804.7" "804.5" "817.4" "" "" "" "" "" "" "" "" "" "" "788.2" "660.0" "780.3" "653.9" "703.3" "811.2" "733.9" "714.5" "804.5" "787.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4762108780726975250" "False" "High" "IsMasterProtein" "O60861" "Growth arrest-specific protein 7 OS=Homo sapiens OX=9606 GN=GAS7 PE=1 SV=3" "0.000" "False" "13.697" "11" "5" "7" "5" "476" "54.3" "7.34" "19.32" "5" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00397, Pf00611, Pf14604, Pf16623" "8522" "ENSG00000007237" "GAS7" "A8KAC2; B2RCK9; hsa:8522; O43144; O60861; Q53Y77; Q7Z571" "" "" "0" "0" "0.984" "0.969" "0.952" "1.085" "1.090" "0.988" "1.054" "0.927" "1.013" "1059.3" "1042.3" "1026.4" "1008.7" "1149.0" "1154.6" "1047.1" "1116.0" "981.8" "1073.3" "" "" "" "" "" "" "" "" "" "" "992.5" "862.5" "952.9" "779.8" "979.4" "1103.1" "956.8" "990.9" "981.8" "1033.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7225862634974144158" "False" "High" "IsMasterProtein" "Q8N392" "Rho GTPase-activating protein 18 OS=Homo sapiens OX=9606 GN=ARHGAP18 PE=1 SV=3" "0.000" "False" "13.687" "6" "5" "7" "5" "663" "74.9" "6.44" "18.25" "5" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00620" "93663" "ENSG00000146376" "ARHGAP18" "E1P575; hsa:93663; Q58EZ3; Q6P679; Q6PJD7; Q8N392; Q96S64" "" "RHOC GTPase cycle; RHOA GTPase cycle" "2" "0" "0.886" "0.988" "0.993" "0.963" "0.988" "0.959" "1.075" "0.952" "1.096" "624.2" "552.9" "616.6" "619.7" "601.1" "616.9" "598.7" "671.2" "594.0" "684.4" "" "" "" "" "" "" "" "" "" "" "584.8" "457.5" "572.4" "479.0" "512.4" "589.4" "547.1" "596.0" "594.0" "658.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-445851658510322323" "False" "High" "IsMasterProtein" "P55769" "NHP2-like protein 1 OS=Homo sapiens OX=9606 GN=SNU13 PE=1 SV=3" "0.000" "False" "13.654" "25" "3" "7" "3" "128" "14.2" "8.46" "24.25" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01248" "4809" "ENSG00000100138" "SNU13" "hsa:4809; P55769" "mRNA processing" "mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "4" "0" "1.168" "1.033" "1.248" "1.149" "1.117" "1.241" "1.412" "1.407" "1.165" "193.0" "225.5" "199.3" "240.8" "221.8" "215.7" "239.5" "272.6" "271.6" "224.8" "" "" "" "" "" "" "" "" "" "" "180.9" "186.6" "185.0" "186.1" "189.1" "206.0" "218.8" "242.0" "271.6" "216.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5357414389544456501" "False" "High" "IsMasterProtein" "P55212" "Caspase-6 OS=Homo sapiens OX=9606 GN=CASP6 PE=1 SV=2" "0.000" "False" "13.652" "18" "5" "5" "4" "293" "33.3" "6.93" "15.68" "5" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00656" "839" "ENSG00000138794" "CASP6" "hsa:839; P55212; Q9BQE7" "Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Acute viral myocarditis" "TP53 Regulates Transcription of Caspase Activators and Caspases; Caspase-mediated cleavage of cytoskeletal proteins; Breakdown of the nuclear lamina" "10" "0" "1.042" "0.916" "1.220" "1.126" "0.976" "1.037" "1.018" "0.979" "0.971" "89.6" "93.3" "82.1" "109.2" "100.9" "87.4" "92.9" "91.1" "87.7" "86.9" "" "" "" "" "" "" "" "" "" "" "83.9" "77.2" "76.2" "84.4" "86.0" "83.5" "84.8" "80.9" "87.7" "83.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8357851412820186252" "False" "High" "IsMasterProtein" "O60675" "Transcription factor MafK OS=Homo sapiens OX=9606 GN=MAFK PE=1 SV=1" "0.000" "False" "13.649" "36" "5" "6" "5" "156" "17.5" "10.10" "12.50" "5" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03131" "7975" "ENSG00000198517" "MAFK" "A4D214; hsa:7975; O60675" "Quercetin and Nf-kB / AP-1 induced apoptosis; Ethanol metabolism production of ROS by CYP2E1" "Heme signaling; Factors involved in megakaryocyte development and platelet production; Regulation of HMOX1 expression and activity; Regulation of BACH1 activity; NFE2L2 regulating anti-oxidant/detoxification enzymes; NFE2L2 regulating MDR associated enzymes; Nuclear events mediated by NFE2L2; NFE2L2 regulating inflammation associated genes; NFE2L2 regulating tumorigenic genes; NFE2L2 regulating ER-stress associated genes; Regulation of NFE2L2 gene expression" "13" "0" "1.026" "0.986" "1.071" "1.052" "0.967" "0.970" "0.969" "0.945" "0.938" "325.4" "333.8" "320.7" "348.6" "342.2" "314.8" "315.6" "315.4" "307.5" "305.4" "" "" "" "" "" "" "" "" "" "" "304.9" "276.2" "297.8" "269.5" "291.7" "300.8" "288.4" "280.0" "307.5" "294.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4718319405373936898" "False" "High" "IsMasterProtein" "Q5TA45" "Integrator complex subunit 11 OS=Homo sapiens OX=9606 GN=INTS11 PE=1 SV=2" "0.000" "False" "13.646" "8" "5" "5" "5" "600" "67.6" "8.06" "14.94" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07521, Pf10996, Pf16661, Pf21386" "54973" "ENSG00000127054" "INTS11" "A8K5S2; B3KPR3; B4DM87; G3V1S5; hsa:54973; Q5TA45; Q5TA46; Q5TA48; Q5TA52; Q5TA53; Q5TA54; Q7L3D7; Q96HY1; Q9BW36; Q9H0F9; Q9H8R5; Q9HAA6; Q9NWX9" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.121" "1.063" "1.058" "1.020" "1.009" "0.939" "0.992" "1.057" "1.041" "773.2" "867.0" "821.6" "818.2" "788.5" "780.2" "725.9" "767.1" "817.5" "805.0" "" "" "" "" "" "" "" "" "" "" "724.5" "717.4" "762.8" "632.5" "672.1" "745.4" "663.3" "681.1" "817.5" "775.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5819226307907089360" "False" "High" "IsMasterProtein" "Q99996" "A-kinase anchor protein 9 OS=Homo sapiens OX=9606 GN=AKAP9 PE=1 SV=4" "0.000" "False" "13.641" "1" "5" "5" "5" "3907" "452.7" "4.98" "15.34" "5" "cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf10495" "10142" "ENSG00000127914" "AKAP9" "A4D1F0; A4D1F2; A4D1F4; hsa:10142; O14869; O43355; O94895; Q75N20; Q99996; Q9UQH3; Q9UQQ4; Q9Y6B8; Q9Y6Y2" "G protein signaling pathways; NO/cGMP/PKG mediated neuroprotection" "Signaling by BRAF and RAF1 fusions; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Phase 3 - rapid repolarisation; Phase 2 - plateau phase" "12" "0" "0.971" "0.955" "0.987" "1.006" "0.933" "0.979" "0.945" "0.875" "0.960" "449.4" "436.2" "429.3" "443.6" "452.3" "419.5" "440.0" "424.7" "393.0" "431.5" "" "" "" "" "" "" "" "" "" "" "421.1" "361.0" "398.6" "342.9" "385.5" "400.8" "402.0" "377.1" "393.0" "415.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5044889676122240904" "False" "High" "IsMasterProtein" "Q9H270" "Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens OX=9606 GN=VPS11 PE=1 SV=1" "0.000" "False" "13.636" "5" "5" "5" "5" "941" "107.8" "7.05" "14.81" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00637, Pf12451, Pf13923" "55823" "" "VPS11" "hsa:55823; Q8WY89; Q96EP8; Q9H270; Q9H6D9; Q9HCS6" "Network map of SARS-CoV-2 signaling pathway" "SARS-CoV-2 modulates autophagy" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8966117974293097362" "False" "High" "IsMasterProtein" "Q9UHL4" "Dipeptidyl peptidase 2 OS=Homo sapiens OX=9606 GN=DPP7 PE=1 SV=3" "0.000" "False" "13.635" "10" "5" "5" "5" "492" "54.3" "6.32" "13.58" "5" "protein metabolism;other metabolic processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05577" "29952" "ENSG00000176978" "DPP7" "A8K7U7; hsa:29952; Q5VSF1; Q969X4; Q9UHL4" "" "Neutrophil degranulation" "1" "0" "0.920" "0.911" "1.036" "1.072" "0.980" "0.991" "0.971" "0.900" "0.931" "358.1" "329.4" "326.1" "371.1" "384.0" "351.1" "354.9" "347.9" "322.4" "333.2" "" "" "" "" "" "" "" "" "" "" "335.5" "272.6" "302.7" "286.9" "327.3" "335.4" "324.3" "308.9" "322.4" "320.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-788718536083084523" "False" "High" "IsMasterProtein" "Q9ULR0" "Pre-mRNA-splicing factor ISY1 homolog OS=Homo sapiens OX=9606 GN=ISY1 PE=1 SV=3" "0.000" "False" "13.631" "13" "4" "5" "4" "285" "33.0" "5.17" "18.84" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf06246" "100534599; 57461" "ENSG00000240682" "ISY1" "hsa:100534599; hsa:57461; Q96IL2; Q9BT05; Q9ULR0" "" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "5" "0" "0.994" "0.933" "0.913" "1.007" "1.046" "1.006" "1.053" "1.068" "1.021" "1038.3" "1031.9" "968.3" "947.8" "1045.1" "1086.5" "1044.6" "1093.1" "1109.1" "1060.0" "" "" "" "" "" "" "" "" "" "" "972.9" "853.9" "898.9" "732.7" "890.8" "1038.1" "954.5" "970.5" "1109.1" "1020.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6207742459099857160" "False" "High" "IsMasterProtein" "Q9UJ41" "Rab5 GDP/GTP exchange factor OS=Homo sapiens OX=9606 GN=RABGEF1 PE=1 SV=3" "0.000" "False" "13.629" "9" "4" "4" "4" "491" "56.9" "7.02" "13.76" "4" "transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01754, Pf02204, Pf18151" "27342" "ENSG00000154710" "RABGEF1" "B4DZM7; hsa:27342; Q3HKR2; Q3HKR3; Q53FG0; Q9UJ41" "16p11.2 distal deletion syndrome" "RAB GEFs exchange GTP for GDP on RABs; TBC/RABGAPs" "3" "0" "1.004" "0.978" "0.990" "1.015" "1.020" "0.926" "0.928" "0.972" "0.984" "899.7" "903.4" "879.8" "891.0" "913.6" "917.4" "833.0" "835.3" "874.6" "885.2" "" "" "" "" "" "" "" "" "" "" "843.0" "747.5" "816.8" "688.8" "778.7" "876.5" "761.1" "741.6" "874.6" "852.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5233814876495562801" "False" "High" "IsMasterProtein" "P00966" "Argininosuccinate synthase OS=Homo sapiens OX=9606 GN=ASS1 PE=1 SV=2" "0.000" "False" "13.624" "12" "6" "9" "6" "412" "46.5" "8.02" "26.30" "6" "other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00764, Pf20979" "445" "ENSG00000130707" "ASS1" "hsa:445; P00966; Q6LDL2; Q86UZ0; Q96GT4" "Alanine and aspartate metabolism; Amino acid metabolism" "Urea cycle" "3" "0" "0.955" "0.967" "0.914" "0.900" "0.985" "0.971" "0.925" "0.902" "0.938" "616.2" "588.7" "596.1" "563.5" "554.3" "607.1" "598.4" "570.1" "556.1" "577.9" "" "" "" "" "" "" "" "" "" "" "577.4" "487.1" "553.4" "435.6" "472.5" "580.0" "546.8" "506.2" "556.1" "556.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7328219287373480262" "False" "High" "IsMasterProtein" "Q7LG56" "Ribonucleoside-diphosphate reductase subunit M2 B OS=Homo sapiens OX=9606 GN=RRM2B PE=1 SV=1" "0.000" "False" "13.593" "12" "4" "6" "2" "351" "40.7" "4.97" "20.81" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00268" "50484" "ENSG00000048392" "RRM2B" "B4E2N4; hsa:50484; Q17R22; Q75PQ6; Q75PQ7; Q75PY8; Q75PY9; Q7LG56; Q86YE3; Q9NPD6; Q9NTD8; Q9NUW3" "miRNA regulation of DNA damage response; Pyrimidine metabolism; p53 transcriptional gene network; DNA damage response" "TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates" "6" "0" "0.899" "0.954" "0.962" "0.925" "0.957" "0.963" "0.952" "0.903" "0.948" "327.7" "294.6" "312.5" "315.3" "303.2" "313.6" "315.6" "311.9" "295.8" "310.8" "" "" "" "" "" "" "" "" "" "" "307.1" "243.8" "290.1" "243.7" "258.5" "299.7" "288.4" "276.9" "295.8" "299.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7482655995969634953" "False" "High" "IsMasterProtein" "Q9Y237" "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 OS=Homo sapiens OX=9606 GN=PIN4 PE=1 SV=1" "0.000" "False" "13.585" "31" "4" "7" "4" "131" "13.8" "9.77" "22.61" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13616" "5303" "ENSG00000102309" "PIN4" "A8E0G6; B3KXM0; F5H1P5; hsa:5303; Q0D2H3; Q3MHV0; Q52M21; Q5HYW6; Q6IRW4; Q9Y237" "" "" "0" "0" "1.077" "1.070" "0.963" "0.969" "0.951" "0.894" "0.935" "0.948" "1.014" "887.5" "955.4" "949.9" "854.3" "859.9" "844.1" "793.2" "829.9" "841.6" "899.8" "" "" "" "" "" "" "" "" "" "" "831.5" "790.6" "881.8" "660.4" "733.0" "806.5" "724.8" "736.9" "841.6" "866.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8229141518412539790" "False" "High" "IsMasterProtein" "P68036" "Ubiquitin-conjugating enzyme E2 L3 OS=Homo sapiens OX=9606 GN=UBE2L3 PE=1 SV=1" "0.000" "False" "13.561" "27" "5" "8" "5" "154" "17.9" "8.51" "19.70" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00179" "7332" "ENSG00000185651" "UBE2L3" "B2R4A7; B4DDG1; B4DSZ4; E7EWS7; hsa:7332; P51966; P68036; P70653; Q9HAV1" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; Regulation of necroptotic cell death; Regulation of TNFR1 signaling" "7" "0" "0.963" "0.953" "0.855" "0.947" "0.879" "0.978" "0.967" "0.916" "0.935" "655.8" "631.7" "625.1" "560.7" "621.3" "576.6" "641.0" "633.8" "600.8" "613.1" "" "" "" "" "" "" "" "" "" "" "614.4" "522.7" "580.3" "433.5" "529.6" "550.9" "585.7" "562.8" "600.8" "590.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7933868971006090466" "False" "High" "IsMasterProtein" "Q8WUH2" "Transforming growth factor-beta receptor-associated protein 1 OS=Homo sapiens OX=9606 GN=TGFBRAP1 PE=1 SV=1" "0.000" "False" "13.548" "5" "5" "5" "5" "860" "97.1" "6.55" "16.02" "5" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00637, Pf00780, Pf10366, Pf10367" "9392" "ENSG00000135966" "TGFBRAP1" "A8K5R7; D3DVJ8; hsa:9392; O60466; Q8WUH2" "" "" "0" "0" "1.001" "1.044" "1.038" "0.947" "1.003" "0.950" "0.995" "0.947" "0.968" "526.5" "526.9" "549.7" "546.5" "498.4" "528.0" "500.3" "523.8" "498.8" "509.9" "" "" "" "" "" "" "" "" "" "" "493.3" "436.0" "510.3" "422.5" "424.8" "504.5" "457.1" "465.1" "498.8" "490.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1299453744240154091" "False" "High" "IsMasterProtein" "Q96EB1" "Elongator complex protein 4 OS=Homo sapiens OX=9606 GN=ELP4 PE=1 SV=2" "0.000" "False" "13.541" "13" "5" "5" "5" "424" "46.6" "8.51" "17.53" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf05625" "26610" "ENSG00000109911" "ELP4" "B4E3W0; E7EPZ6; hsa:26610; Q96EB1; Q9H4E8; Q9NX11" "Mesodermal commitment pathway" "HATs acetylate histones" "2" "0" "0.993" "0.953" "0.903" "0.999" "1.023" "0.920" "0.976" "0.969" "1.005" "807.8" "802.3" "770.2" "729.1" "806.6" "826.5" "743.5" "788.2" "783.0" "811.9" "" "" "" "" "" "" "" "" "" "" "756.9" "663.9" "715.1" "563.7" "687.6" "789.6" "679.3" "699.9" "783.0" "781.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7369433181564394735" "False" "High" "IsMasterProtein" "P08708" "Small ribosomal subunit protein eS17 OS=Homo sapiens OX=9606 GN=RPS17 PE=1 SV=2" "0.000" "False" "13.537" "23" "4" "6" "4" "135" "15.5" "9.85" "16.91" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00833" "6218" "ENSG00000182774; ENSG00000278229" "RPS17" "B2R4U4; hsa:6218; P08708; P0CW22" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.981" "1.026" "1.073" "1.087" "1.137" "1.177" "1.137" "1.149" "1.157" "527.8" "517.6" "541.5" "566.2" "573.6" "600.2" "621.0" "600.3" "606.3" "610.8" "" "" "" "" "" "" "" "" "" "" "494.5" "428.3" "502.7" "437.7" "488.9" "573.5" "567.4" "533.0" "606.3" "588.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-780269141344007222" "False" "High" "IsMasterProtein" "P15814" "Immunoglobulin lambda-like polypeptide 1 OS=Homo sapiens OX=9606 GN=IGLL1 PE=1 SV=1" "0.000" "False" "13.520" "26" "4" "6" "4" "213" "22.9" "10.07" "24.20" "4" "other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf07654" "3543" "ENSG00000128322" "IGLL1" "hsa:3543; P15814; Q0P681" "Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway" "Cell surface interactions at the vascular wall" "3" "0" "1.001" "0.985" "0.955" "0.949" "0.925" "0.833" "0.861" "0.847" "0.930" "1404.5" "1406.2" "1383.8" "1341.6" "1332.8" "1299.1" "1170.5" "1209.9" "1189.7" "1305.7" "" "" "" "" "" "" "" "" "" "" "1316.0" "1163.6" "1284.7" "1037.1" "1136.0" "1241.1" "1069.5" "1074.3" "1189.7" "1257.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4527223765443096832" "False" "High" "IsMasterProtein" "O95785" "Protein Wiz OS=Homo sapiens OX=9606 GN=WIZ PE=1 SV=2" "0.000" "False" "13.514" "3" "5" "5" "5" "1651" "178.6" "6.86" "16.69" "5" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "58525" "ENSG00000011451" "WIZ" "B3KVH1; B7ZM82; hsa:58525; M0QY21; O95785; Q4G0E0; Q6P6B0; Q6ZN24; Q7LDY6; Q7LDZ1; Q96IG5; Q96SQ6; Q9BUR8; Q9NPT1" "" "" "0" "0" "0.991" "1.006" "0.988" "0.982" "0.936" "1.044" "0.985" "0.952" "0.972" "362.7" "359.6" "365.0" "358.3" "356.2" "339.4" "378.6" "357.3" "345.4" "352.7" "" "" "" "" "" "" "" "" "" "" "339.8" "297.5" "338.9" "277.0" "303.6" "324.3" "345.9" "317.2" "345.4" "339.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5658757101665122516" "False" "High" "IsMasterProtein" "Q9ULP9" "TBC1 domain family member 24 OS=Homo sapiens OX=9606 GN=TBC1D24 PE=1 SV=2" "0.000" "False" "13.505" "11" "7" "7" "7" "559" "62.9" "7.36" "17.86" "7" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity" "Pf00566, Pf07534" "57465" "ENSG00000162065" "TBC1D24" "A0JNW3; B9A6M6; hsa:57465; Q2KJ08; Q9ULP9" "" "TBC/RABGAPs" "1" "0" "0.934" "1.042" "0.978" "1.016" "0.979" "0.983" "1.000" "0.995" "1.023" "596.7" "557.1" "621.8" "583.4" "606.1" "584.1" "586.4" "596.5" "593.7" "610.3" "" "" "" "" "" "" "" "" "" "" "559.1" "461.0" "577.3" "451.0" "516.6" "558.0" "535.8" "529.7" "593.7" "587.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8590032029601755120" "False" "High" "IsMasterProtein" "O75935" "Dynactin subunit 3 OS=Homo sapiens OX=9606 GN=DCTN3 PE=1 SV=1" "0.000" "False" "13.485" "23" "5" "5" "5" "186" "21.1" "5.47" "16.69" "5" "cell cycle OR cell proliferation;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07426" "11258" "ENSG00000137100" "DCTN3" "A6NII7; B2RBM5; hsa:11258; O75935; Q5T1I5; Q5T1I7; Q5T8G3; Q9BPU8" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic" "11" "0" "0.933" "0.963" "0.987" "0.998" "1.123" "0.919" "0.949" "0.972" "1.014" "967.0" "902.5" "931.0" "954.2" "965.0" "1085.5" "888.7" "918.0" "939.5" "980.8" "" "" "" "" "" "" "" "" "" "" "906.1" "746.8" "864.3" "737.7" "822.5" "1037.1" "812.0" "815.1" "939.5" "944.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-123895126992999128" "False" "High" "IsMasterProtein" "Q96BR5" "Cytochrome c oxidase assembly factor 7 OS=Homo sapiens OX=9606 GN=COA7 PE=1 SV=2" "0.000" "False" "13.473" "17" "5" "5" "5" "231" "25.7" "6.02" "16.29" "5" "" "mitochondrion;nucleus" "" "Pf08238" "65260" "ENSG00000162377" "COA7" "hsa:65260; Q0P6I7; Q96BR5; Q9H9Z9" "" "" "0" "0" "1.074" "0.997" "1.015" "1.052" "1.000" "0.934" "0.930" "0.879" "1.006" "412.9" "443.6" "411.5" "419.0" "434.5" "412.9" "385.8" "384.0" "363.0" "415.5" "" "" "" "" "" "" "" "" "" "" "386.9" "367.1" "382.0" "323.9" "370.4" "394.5" "352.5" "341.0" "363.0" "400.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2244987817245821138" "False" "High" "IsMasterProtein" "Q14004" "Cyclin-dependent kinase 13 OS=Homo sapiens OX=9606 GN=CDK13 PE=1 SV=2" "0.000" "False" "13.468" "3" "5" "7" "3" "1512" "164.8" "9.69" "21.28" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8621" "ENSG00000065883" "CDK13" "hsa:8621; Q14004; Q53G78; Q6DKQ9; Q75MH4; Q75MH5; Q96JN4; Q9H4A0; Q9H4A1; Q9UDR4" "" "Neutrophil degranulation; TP53 Regulates Transcription of DNA Repair Genes" "2" "0" "1.019" "1.039" "1.106" "1.115" "1.078" "1.036" "1.059" "1.059" "1.095" "579.3" "590.1" "601.6" "640.7" "645.8" "624.4" "600.0" "613.6" "613.6" "634.1" "" "" "" "" "" "" "" "" "" "" "542.8" "488.3" "558.5" "495.3" "550.4" "596.5" "548.3" "544.8" "613.6" "610.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7630345377865006626" "False" "High" "IsMasterProtein" "Q9NVS9" "Pyridoxine-5'-phosphate oxidase OS=Homo sapiens OX=9606 GN=PNPO PE=1 SV=1" "0.000" "False" "13.465" "19" "4" "6" "4" "261" "30.0" "7.06" "17.45" "4" "other metabolic processes" "cytosol" "other molecular function" "Pf01243, Pf10590" "55163" "ENSG00000108439" "PNPO" "B4E0V0; B4E152; B4E1D7; D3DTT9; hsa:55163; Q9NVS9" "Selenium micronutrient network; Vitamin B6-dependent and responsive disorders" "Vitamin B6 activation to pyridoxal phosphate" "3" "0" "0.899" "0.984" "1.016" "1.086" "1.093" "0.875" "1.012" "0.831" "0.957" "56.5" "50.8" "55.6" "57.4" "61.3" "61.7" "49.4" "57.2" "47.0" "54.1" "" "" "" "" "" "" "" "" "" "" "52.9" "42.0" "51.6" "44.3" "52.3" "59.0" "45.1" "50.8" "47.0" "52.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3087577180827751856" "False" "High" "IsMasterProtein" "Q15172" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R5A PE=1 SV=1" "0.000" "False" "13.458" "9" "4" "4" "3" "486" "56.2" "6.71" "12.44" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01603" "5525" "ENSG00000066027" "PPP2R5A" "B2R6D2; B7Z7L2; D3DT99; hsa:5525; Q15172; Q2NL72; Q5VVB2; Q8TBI9" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "PKR-mediated signaling; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling" "27" "0" "0.946" "0.972" "1.006" "1.126" "0.870" "1.257" "1.029" "0.955" "0.931" "25.9" "24.5" "25.2" "26.1" "29.2" "22.5" "32.6" "26.7" "24.7" "24.1" "" "" "" "" "" "" "" "" "" "" "24.3" "20.3" "23.4" "20.1" "24.9" "21.5" "29.8" "23.7" "24.7" "23.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6008736440558391918" "False" "High" "IsMasterProtein" "O75157" "TSC22 domain family protein 2 OS=Homo sapiens OX=9606 GN=TSC22D2 PE=1 SV=3" "0.000" "False" "13.451" "6" "5" "6" "3" "780" "79.2" "5.02" "14.92" "5" "stress response;other biological processes" "" "" "Pf01166" "9819" "ENSG00000196428" "TSC22D2" "D3DNI5; hsa:9819; O75157; Q6PI50; Q9H2Z6; Q9H2Z7; Q9H2Z8" "" "" "0" "0" "0.939" "0.917" "0.973" "0.942" "0.998" "0.914" "0.918" "0.850" "0.934" "255.4" "239.7" "234.3" "248.5" "240.5" "254.8" "233.5" "234.4" "217.0" "238.4" "" "" "" "" "" "" "" "" "" "" "239.3" "198.3" "217.5" "192.1" "205.0" "243.4" "213.3" "208.1" "217.0" "229.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2304396321486536577" "False" "High" "IsMasterProtein" "Q8IXQ4" "GPALPP motifs-containing protein 1 OS=Homo sapiens OX=9606 GN=GPALPP1 PE=1 SV=1" "0.000" "False" "13.448" "16" "4" "4" "4" "340" "38.1" "5.41" "15.07" "4" "" "" "" "Pf12572" "55425" "ENSG00000133114" "GPALPP1" "A8K8X8; hsa:55425; Q05BX8; Q05D87; Q5T3Z3; Q5T3Z5; Q8IXQ4; Q9C0F9; Q9H2R0; Q9P0W6" "" "" "0" "0" "1.256" "1.133" "1.282" "1.119" "1.142" "1.006" "1.138" "1.174" "1.135" "277.9" "348.9" "314.9" "356.3" "311.0" "317.3" "279.5" "316.1" "326.1" "315.5" "" "" "" "" "" "" "" "" "" "" "260.4" "288.7" "292.4" "275.4" "265.1" "303.2" "255.4" "280.7" "326.1" "303.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3324031393637842436" "False" "High" "IsMasterProtein" "P49458" "Signal recognition particle 9 kDa protein OS=Homo sapiens OX=9606 GN=SRP9 PE=1 SV=2" "0.000" "False" "13.443" "50" "5" "7" "5" "86" "10.1" "7.97" "17.12" "5" "other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf05486" "6726" "ENSG00000143742" "SRP9" "A8K0N0; hsa:6726; P49458; Q6NVX0; Q8WTW0" "" "SRP-dependent cotranslational protein targeting to membrane" "1" "0" "1.163" "1.071" "1.032" "1.074" "1.047" "1.177" "1.127" "0.979" "1.024" "476.4" "554.1" "510.3" "491.6" "511.8" "498.7" "560.8" "536.8" "466.4" "488.0" "" "" "" "" "" "" "" "" "" "" "446.4" "458.6" "473.8" "380.1" "436.2" "476.4" "512.4" "476.7" "466.4" "469.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "289825156273590713" "False" "High" "IsMasterProtein" "Q5JTV8" "Torsin-1A-interacting protein 1 OS=Homo sapiens OX=9606 GN=TOR1AIP1 PE=1 SV=2" "0.000" "False" "13.436" "7" "3" "6" "3" "583" "66.2" "8.18" "24.73" "3" "cell organization and biogenesis;other biological processes" "other membranes;nucleus" "cytoskeletal activity;other molecular function" "Pf05609, Pf20443" "26092" "ENSG00000143337" "TOR1AIP1" "A0A0A0MSK5; A8K630; B0QZ57; hsa:26092; Q5JTV6; Q5JTV8; Q8IZ65; Q9H8Y6; Q9HAJ1; Q9NV52; Q9Y3X5" "Influence of laminopathies on Wnt signaling" "RHOD GTPase cycle; RHOF GTPase cycle" "3" "0" "1.082" "1.042" "1.117" "1.166" "1.135" "1.225" "1.203" "1.115" "1.108" "300.3" "325.0" "312.9" "335.4" "350.1" "340.8" "367.8" "361.2" "334.6" "332.6" "" "" "" "" "" "" "" "" "" "" "281.3" "268.9" "290.5" "259.3" "298.4" "325.6" "336.1" "320.7" "334.6" "320.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7153575726197497326" "False" "High" "IsMasterProtein" "Q7Z6B0" "Coiled-coil domain-containing protein 91 OS=Homo sapiens OX=9606 GN=CCDC91 PE=1 SV=2" "0.000" "False" "13.435" "9" "5" "6" "5" "441" "49.9" "5.07" "14.64" "5" "transport" "other membranes;cytosol;ER/Golgi;nucleus" "" "" "55297" "ENSG00000123106" "CCDC91" "B3KSA3; C9JR07; hsa:55297; Q68D43; Q6IA78; Q7Z6B0; Q8NEN7; Q9NUW9" "" "" "0" "0" "0.986" "0.925" "0.952" "1.000" "0.987" "0.992" "1.009" "1.046" "0.971" "816.0" "804.2" "755.1" "776.7" "815.9" "805.3" "809.4" "823.7" "853.6" "792.3" "" "" "" "" "" "" "" "" "" "" "764.6" "665.5" "701.0" "600.4" "695.4" "769.4" "739.6" "731.4" "853.6" "762.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1711766393091945325" "False" "High" "IsMasterProtein" "Q6DKK2" "Tetratricopeptide repeat protein 19, mitochondrial OS=Homo sapiens OX=9606 GN=TTC19 PE=1 SV=4" "0.000" "False" "13.433" "11" "4" "4" "4" "380" "42.4" "5.77" "13.91" "4" "cell cycle OR cell proliferation;cell organization and biogenesis" "other membranes;cytoskeleton;mitochondrion;other cell component" "" "Pf13374, Pf13424" "54902" "ENSG00000011295" "TTC19" "A8MZ52; B3KP62; B4DN65; hsa:54902; Q2M248; Q6DKK2; Q7L3U8; Q9H6G3; Q9NXB2" "Mitochondrial complex III assembly" "" "1" "0" "0.960" "0.963" "0.879" "0.946" "1.049" "0.832" "0.958" "0.924" "0.988" "530.3" "509.2" "510.6" "465.9" "501.5" "556.4" "441.0" "508.1" "490.1" "523.9" "" "" "" "" "" "" "" "" "" "" "496.8" "421.4" "474.0" "360.1" "427.4" "531.6" "402.9" "451.2" "490.1" "504.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1425618486899947959" "False" "High" "IsMasterProtein" "Q7Z4H3" "5'-deoxynucleotidase HDDC2 OS=Homo sapiens OX=9606 GN=HDDC2 PE=1 SV=1" "0.000" "False" "13.428" "27" "5" "7" "5" "204" "23.4" "5.49" "21.30" "5" "" "" "other molecular function" "Pf13023" "51020" "ENSG00000111906" "HDDC2" "hsa:51020; Q5TDQ4; Q6NZ49; Q7Z4H3; Q9BTT2; Q9BV31; Q9Y3D1" "" "" "0" "0" "1.078" "1.057" "0.983" "1.072" "1.071" "1.007" "1.012" "1.034" "1.060" "1035.3" "1115.7" "1094.5" "1018.0" "1110.2" "1109.2" "1043.0" "1047.5" "1070.7" "1097.8" "" "" "" "" "" "" "" "" "" "" "970.0" "923.3" "1016.1" "787.0" "946.3" "1059.8" "953.0" "930.1" "1070.7" "1057.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4842001087563209976" "False" "High" "IsMasterProtein" "Q9NVN8" "Guanine nucleotide-binding protein-like 3-like protein OS=Homo sapiens OX=9606 GN=GNL3L PE=1 SV=1" "0.000" "False" "13.417" "8" "4" "4" "3" "582" "65.5" "8.44" "13.25" "4" "other biological processes" "cytosol;nucleus" "other molecular function" "Pf01926" "54552" "ENSG00000130119" "GNL3L" "hsa:54552; Q9NVN8" "" "" "0" "0" "1.228" "1.026" "1.771" "1.288" "0.916" "1.377" "1.298" "1.094" "1.017" "20.7" "25.4" "21.2" "36.6" "26.6" "18.9" "28.5" "26.8" "22.6" "21.0" "" "" "" "" "" "" "" "" "" "" "19.4" "21.0" "19.7" "28.3" "22.7" "18.1" "26.0" "23.8" "22.6" "20.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8417991388953307590" "False" "High" "IsMasterProtein" "O75064" "DENN domain-containing protein 4B OS=Homo sapiens OX=9606 GN=DENND4B PE=1 SV=4" "0.000" "False" "13.411" "3" "5" "5" "5" "1496" "163.7" "7.21" "12.71" "5" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf02141, Pf03455, Pf03456" "9909" "ENSG00000198837" "DENND4B" "hsa:9909; O75064; Q5T4K0" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.010" "0.919" "1.049" "1.052" "0.983" "1.075" "0.982" "0.976" "0.949" "523.6" "529.1" "481.0" "549.1" "551.0" "514.5" "563.2" "514.2" "511.2" "496.8" "" "" "" "" "" "" "" "" "" "" "490.6" "437.8" "446.6" "424.5" "469.7" "491.5" "514.6" "456.5" "511.2" "478.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1864840127282000894" "False" "High" "IsMasterProtein" "Q9Y2I1" "Nischarin OS=Homo sapiens OX=9606 GN=NISCH PE=1 SV=3" "0.000" "False" "13.397" "3" "5" "5" "5" "1504" "166.5" "5.14" "14.21" "5" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00787" "11188" "ENSG00000010322" "NISCH" "C9J245; hsa:11188; Q6PGP3; Q6PIB4; Q7L8M3; Q7Z2X6; Q9UES6; Q9UEU4; Q9UFW3; Q9Y2I1" "" "RAC1 GTPase cycle; RND2 GTPase cycle; RND3 GTPase cycle" "3" "0" "1.035" "1.009" "1.062" "0.969" "0.922" "1.038" "0.950" "0.872" "0.985" "262.9" "272.1" "265.2" "279.1" "254.9" "242.5" "272.9" "249.7" "229.2" "258.9" "" "" "" "" "" "" "" "" "" "" "246.3" "225.2" "246.2" "215.8" "217.2" "231.7" "249.3" "221.7" "229.2" "249.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "295082137940750650" "False" "High" "IsMasterProtein" "O43633" "Charged multivesicular body protein 2a OS=Homo sapiens OX=9606 GN=CHMP2A PE=1 SV=1" "0.000" "False" "13.394" "16" "4" "4" "4" "222" "25.1" "5.97" "19.04" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "27243" "ENSG00000130724" "CHMP2A" "B2R4W6; hsa:27243; O43633; Q3ZTT0" "" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Lysosome Vesicle Biogenesis; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "10" "0" "1.083" "0.962" "1.100" "1.063" "1.049" "0.984" "1.036" "1.021" "1.017" "527.2" "571.0" "507.3" "579.8" "560.3" "553.2" "518.8" "546.0" "538.1" "535.9" "" "" "" "" "" "" "" "" "" "" "494.0" "472.5" "470.9" "448.2" "477.6" "528.5" "474.1" "484.8" "538.1" "516.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2375435199137725135" "False" "High" "IsMasterProtein" "Q96MH2" "Protein HEXIM2 OS=Homo sapiens OX=9606 GN=HEXIM2 PE=1 SV=1" "0.000" "False" "13.356" "14" "5" "6" "4" "286" "32.4" "6.55" "19.12" "5" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf15313" "124790" "ENSG00000168517" "HEXIM2" "D3DX66; hsa:124790; Q96MH2" "" "" "0" "0" "1.060" "1.025" "1.023" "1.088" "1.085" "1.027" "1.026" "1.089" "1.028" "780.9" "827.5" "800.4" "799.0" "849.3" "847.3" "801.8" "801.2" "850.5" "802.7" "" "" "" "" "" "" "" "" "" "" "731.7" "684.7" "743.1" "617.6" "724.0" "809.5" "732.6" "711.4" "850.5" "772.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4636367879172640363" "False" "High" "IsMasterProtein" "P24666" "Low molecular weight phosphotyrosine protein phosphatase OS=Homo sapiens OX=9606 GN=ACP1 PE=1 SV=3" "0.000" "False" "13.352" "30" "4" "6" "4" "158" "18.0" "6.74" "22.84" "4" "" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01451" "52" "ENSG00000143727" "ACP1" "A8K1L9; B5MCC7; hsa:52; P24666; P24667; Q16035; Q16036; Q16725; Q3KQX8; Q53RU0" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.115" "1.008" "1.126" "1.026" "0.951" "1.016" "1.009" "1.030" "1.033" "375.2" "418.5" "378.2" "422.5" "384.9" "357.0" "381.4" "378.8" "386.6" "387.8" "" "" "" "" "" "" "" "" "" "" "351.6" "346.3" "351.1" "326.6" "328.1" "341.0" "348.5" "336.3" "386.6" "373.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3881079650873622249" "False" "High" "IsMasterProtein" "P29466" "Caspase-1 OS=Homo sapiens OX=9606 GN=CASP1 PE=1 SV=1" "0.000" "False" "13.338" "11" "5" "6" "3" "404" "45.1" "5.91" "14.16" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf00656" "834" "ENSG00000137752" "CASP1" "B5MDZ1; hsa:834; P29466; Q53EY6; Q6DMQ1; Q6GSS3; Q6PI75; Q9UCN3" "Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; Amyotrophic lateral sclerosis (ALS); Apoptosis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Pleural mesothelioma; Prostaglandin signaling" "TP53 Regulates Transcription of Caspase Activators and Caspases; The AIM2 inflammasome; NOD1/2 Signaling Pathway; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; Pyroptosis; Interleukin-37 signaling; Interleukin-1 processing; The IPAF inflammasome" "19" "2" "0.962" "0.999" "0.962" "0.974" "0.977" "0.865" "0.870" "0.866" "0.959" "1373.8" "1321.9" "1372.4" "1322.0" "1338.6" "1342.9" "1189.0" "1195.9" "1189.6" "1317.4" "" "" "" "" "" "" "" "" "" "" "1287.3" "1093.8" "1274.1" "1021.9" "1140.9" "1283.0" "1086.4" "1061.8" "1189.6" "1268.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5639426559288223252" "False" "High" "IsMasterProtein" "Q9UMX5" "Neudesin OS=Homo sapiens OX=9606 GN=NENF PE=1 SV=1" "0.000" "False" "13.337" "21" "3" "5" "3" "172" "18.8" "5.69" "17.09" "3" "signal transduction;other biological processes" "non-structural extracellular;other membranes;mitochondrion;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00173" "29937" "ENSG00000117691" "NENF" "A1KYQ8; hsa:29937; Q53FZ6; Q5TM90; Q9UMX5" "" "" "0" "0" "1.076" "0.964" "1.083" "1.136" "1.103" "1.034" "1.086" "1.098" "1.122" "276.2" "297.2" "266.3" "299.2" "313.7" "304.8" "285.6" "300.0" "303.3" "309.9" "" "" "" "" "" "" "" "" "" "" "258.8" "246.0" "247.2" "231.3" "267.4" "291.2" "260.9" "266.4" "303.3" "298.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8973056022317677667" "False" "High" "IsMasterProtein" "Q9BVS4" "Serine/threonine-protein kinase RIO2 OS=Homo sapiens OX=9606 GN=RIOK2 PE=1 SV=2" "0.000" "False" "13.336" "9" "4" "5" "4" "552" "63.2" "5.94" "14.95" "4" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01163, Pf09202" "55781" "ENSG00000058729" "RIOK2" "D6RDI3; hsa:55781; Q9BVS4; Q9NUT0" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.108" "1.105" "1.177" "1.113" "1.165" "1.207" "1.149" "1.223" "1.122" "202.0" "223.8" "223.3" "237.7" "224.8" "235.4" "243.7" "232.0" "247.0" "226.6" "" "" "" "" "" "" "" "" "" "" "189.2" "185.2" "207.3" "183.7" "191.6" "224.9" "222.7" "206.0" "247.0" "218.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1214418954468839603" "False" "High" "IsMasterProtein" "Q96C01" "Protein FAM136A OS=Homo sapiens OX=9606 GN=FAM136A PE=1 SV=1" "0.000" "False" "13.316" "29" "4" "8" "4" "138" "15.6" "7.61" "24.41" "4" "" "other cell component" "" "Pf05811" "84908" "ENSG00000035141" "FAM136A" "hsa:84908; Q96C01; Q96SS3" "" "" "0" "0" "1.082" "1.038" "0.968" "1.046" "0.964" "1.004" "0.956" "0.915" "1.067" "240.6" "260.3" "249.6" "232.8" "251.7" "231.8" "241.5" "230.1" "220.1" "256.6" "" "" "" "" "" "" "" "" "" "" "225.4" "215.4" "231.8" "180.0" "214.6" "221.5" "220.6" "204.3" "220.1" "247.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1721155162359169472" "False" "High" "IsMasterProtein" "Q9UBQ0" "Vacuolar protein sorting-associated protein 29 OS=Homo sapiens OX=9606 GN=VPS29 PE=1 SV=1" "0.000" "False" "13.314" "26" "5" "9" "5" "182" "20.5" "6.79" "21.85" "5" "transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf12850" "51699" "ENSG00000111237" "VPS29" "hsa:51699; Q502Y5; Q6FIF8; Q6IAH3; Q9H0W0; Q9NRP1; Q9NRU7; Q9UBQ0" "" "WNT ligand biogenesis and trafficking" "1" "0" "0.909" "0.991" "0.956" "0.949" "1.049" "0.962" "1.072" "1.044" "1.050" "773.2" "703.0" "766.5" "739.4" "733.8" "811.5" "743.9" "829.0" "807.2" "811.8" "" "" "" "" "" "" "" "" "" "" "724.5" "581.8" "711.6" "571.6" "625.5" "775.3" "679.7" "736.1" "807.2" "781.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3380259188437483549" "False" "High" "IsMasterProtein" "Q9NQ88" "Fructose-2,6-bisphosphatase TIGAR OS=Homo sapiens OX=9606 GN=TIGAR PE=1 SV=1" "0.000" "False" "13.307" "20" "5" "6" "5" "270" "30.0" "7.69" "16.30" "5" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00300" "57103" "ENSG00000078237" "TIGAR" "B2R840; hsa:57103; Q9NQ88" "Metabolic reprogramming in colon cancer; p53 transcriptional gene network" "TP53 Regulates Metabolic Genes" "3" "0" "1.003" "0.966" "1.063" "0.980" "1.063" "0.952" "1.081" "1.006" "1.082" "392.5" "393.7" "379.2" "417.5" "384.5" "417.3" "373.6" "424.3" "395.0" "424.8" "" "" "" "" "" "" "" "" "" "" "367.8" "325.8" "352.1" "322.7" "327.8" "398.7" "341.3" "376.7" "395.0" "409.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2514407203909916173" "False" "High" "IsMasterProtein" "O95363" "Phenylalanine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=FARS2 PE=1 SV=1" "0.000" "False" "13.288" "10" "5" "7" "5" "451" "52.3" "7.46" "21.37" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01409, Pf03147" "10667" "ENSG00000145982" "FARS2" "B2R664; hsa:10667; O95363; Q53F66; Q5TCS3; Q6FG29; Q9NPY7; Q9P062" "" "Mitochondrial tRNA aminoacylation" "1" "0" "0.949" "1.001" "0.982" "1.062" "1.042" "0.960" "0.986" "1.008" "1.027" "576.0" "546.6" "576.4" "565.8" "612.0" "600.4" "553.0" "568.0" "580.4" "591.9" "" "" "" "" "" "" "" "" "" "" "539.8" "452.3" "535.2" "437.4" "521.7" "573.6" "505.3" "504.4" "580.4" "569.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9120276004969488072" "False" "High" "IsMasterProtein" "Q15080" "Neutrophil cytosol factor 4 OS=Homo sapiens OX=9606 GN=NCF4 PE=1 SV=2" "0.000" "False" "13.283" "16" "5" "5" "5" "339" "39.0" "6.83" "15.59" "5" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00564, Pf00787" "4689" "ENSG00000100365" "NCF4" "A8K4F9; hsa:4689; O60808; Q15080; Q86U56; Q9BU98; Q9NP45" "Microglia pathogen phagocytosis pathway; Urotensin-II-mediated signaling pathway; Genetic causes of porto-sinusoidal vascular disease" "VEGFA-VEGFR2 Pathway; RAC1 GTPase cycle; RAC3 GTPase cycle; RAC2 GTPase cycle; Detoxification of Reactive Oxygen Species; ROS and RNS production in phagocytes; Cross-presentation of particulate exogenous antigens (phagosomes); RHO GTPases Activate NADPH Oxidases" "11" "0" "1.108" "1.020" "1.099" "1.022" "1.038" "0.980" "0.930" "1.045" "1.068" "499.4" "553.1" "509.4" "549.0" "510.3" "518.2" "489.5" "464.2" "522.1" "533.1" "" "" "" "" "" "" "" "" "" "" "467.9" "457.7" "472.9" "424.4" "435.0" "495.1" "447.3" "412.2" "522.1" "513.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1056370544189754053" "False" "High" "IsMasterProtein" "P28065" "Proteasome subunit beta type-9 OS=Homo sapiens OX=9606 GN=PSMB9 PE=1 SV=2" "0.000" "False" "13.276" "21" "4" "8" "4" "219" "23.3" "5.03" "27.19" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227" "5698" "ENSG00000239836; ENSG00000240065; ENSG00000240118; ENSG00000240508; ENSG00000242711; ENSG00000243067; ENSG00000243594; ENSG00000243958" "PSMB9" "B0V0T1; hsa:5698; P28065; Q16523; Q5JNW4" "Proteasome degradation; Type II interferon signaling" "FCERI mediated NF-kB activation; Ub-specific processing proteases; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "61" "0" "0.989" "0.922" "1.027" "0.917" "0.943" "0.924" "0.906" "0.936" "0.923" "1226.3" "1212.9" "1130.5" "1258.9" "1124.4" "1156.8" "1133.6" "1110.7" "1148.0" "1131.9" "" "" "" "" "" "" "" "" "" "" "1149.0" "1003.6" "1049.5" "973.2" "958.5" "1105.2" "1035.8" "986.2" "1148.0" "1089.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2653046833350144460" "False" "High" "IsMasterProtein" "Q96JZ2" "Hematopoietic SH2 domain-containing protein OS=Homo sapiens OX=9606 GN=HSH2D PE=1 SV=1" "0.000" "False" "13.271" "15" "4" "5" "4" "352" "39.0" "7.11" "16.94" "4" "signal transduction" "nucleus;other cell component" "" "Pf00017" "84941" "ENSG00000196684" "HSH2D" "B5ME72; hsa:84941; Q6ZNG7; Q96JZ2" "" "" "0" "0" "1.014" "0.953" "0.944" "1.016" "1.024" "0.961" "0.983" "1.066" "1.068" "342.0" "346.8" "326.0" "322.9" "347.4" "350.2" "328.7" "336.0" "364.7" "365.2" "" "" "" "" "" "" "" "" "" "" "320.4" "287.0" "302.6" "249.6" "296.1" "334.5" "300.4" "298.4" "364.7" "351.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4237649288618835376" "False" "High" "IsMasterProtein" "Q9NUP9" "Protein lin-7 homolog C OS=Homo sapiens OX=9606 GN=LIN7C PE=1 SV=1" "0.000" "False" "13.252" "21" "4" "5" "4" "197" "21.8" "8.43" "15.58" "4" "cell-cell signaling;transport;other biological processes" "plasma membrane;other membranes;other cell component" "cytoskeletal activity;other molecular function" "Pf00595, Pf02828" "55327" "ENSG00000148943" "LIN7C" "hsa:55327; Q9NUP9" "" "Neurexins and neuroligins; Assembly and cell surface presentation of NMDA receptors; Dopamine Neurotransmitter Release Cycle" "3" "0" "1.102" "1.001" "0.931" "1.025" "1.020" "1.046" "1.015" "0.972" "0.999" "536.6" "591.4" "537.2" "499.6" "550.1" "547.4" "561.1" "544.8" "521.8" "536.3" "" "" "" "" "" "" "" "" "" "" "502.8" "489.4" "498.8" "386.2" "468.9" "523.0" "512.7" "483.7" "521.8" "516.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9138201911436176215" "False" "High" "IsMasterProtein" "Q13952" "Nuclear transcription factor Y subunit gamma OS=Homo sapiens OX=9606 GN=NFYC PE=1 SV=3" "0.000" "False" "13.247" "10" "5" "5" "5" "458" "50.3" "6.10" "14.86" "5" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "4802" "ENSG00000066136" "NFYC" "B4DUS6; B4DW63; D3DPV9; F8VWM3; hsa:4802; Q13952; Q59GY4; Q5T6K8; Q5T6K9; Q5T6L1; Q5TZR6; Q92869; Q9HBX1; Q9NXB5; Q9UM67; Q9UML0; Q9UMT7" "" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum stress; ATF6 (ATF6-alpha) activates chaperone genes" "5" "0" "0.917" "0.996" "1.135" "0.978" "1.177" "1.105" "1.074" "0.936" "1.003" "98.8" "90.6" "98.4" "112.1" "96.6" "116.3" "109.2" "106.1" "92.5" "99.0" "" "" "" "" "" "" "" "" "" "" "92.6" "75.0" "91.3" "86.7" "82.4" "111.1" "99.7" "94.2" "92.5" "95.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5953183427719841951" "False" "High" "IsMasterProtein" "P18615" "Negative elongation factor E OS=Homo sapiens OX=9606 GN=NELFE PE=1 SV=3" "0.000" "False" "13.246" "19" "5" "7" "5" "380" "43.2" "9.33" "21.65" "5" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "7936" "ENSG00000204356; ENSG00000206268; ENSG00000206357; ENSG00000229363; ENSG00000231044; ENSG00000233801" "NELFE" "A2BE08; B4DUN1; B4DYX9; hsa:7936; P18615; Q5JP74; Q5JP75; Q96F56; Q9NPK2" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "16" "0" "1.137" "1.082" "1.088" "1.097" "1.085" "1.143" "1.088" "1.023" "1.138" "135.1" "153.5" "146.2" "146.9" "148.1" "146.6" "154.4" "147.0" "138.2" "153.7" "" "" "" "" "" "" "" "" "" "" "126.6" "127.1" "135.7" "113.6" "126.3" "140.0" "141.1" "130.5" "138.2" "148.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5219092479354345629" "False" "High" "IsMasterProtein" "O94855" "Protein transport protein Sec24D OS=Homo sapiens OX=9606 GN=SEC24D PE=1 SV=2" "0.000" "False" "13.238" "4" "5" "5" "4" "1032" "112.9" "7.25" "16.34" "5" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "9871" "ENSG00000150961" "SEC24D" "hsa:9871; O94855; Q8IYI7" "Sterol regulatory element-binding proteins (SREBP) signaling" "MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "7" "0" "1.004" "0.996" "0.925" "0.956" "1.003" "0.950" "0.995" "0.997" "0.931" "330.9" "332.4" "329.6" "306.0" "316.4" "331.9" "314.2" "329.3" "329.9" "308.1" "" "" "" "" "" "" "" "" "" "" "310.1" "275.0" "306.0" "236.6" "269.7" "317.1" "287.1" "292.4" "329.9" "296.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "877971590202694443" "False" "High" "IsMasterProtein" "Q6ZMZ3" "Nesprin-3 OS=Homo sapiens OX=9606 GN=SYNE3 PE=1 SV=2" "0.000" "False" "13.227" "4" "4" "5" "4" "975" "112.1" "6.23" "14.47" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00435, Pf10541" "161176" "ENSG00000176438" "SYNE3" "A6H8H3; Q6ZMZ3; Q86SX5; Q8N7G8" "Envelope proteins and their potential roles in EDMD physiopathology" "" "1" "0" "0.957" "0.945" "1.306" "1.133" "0.941" "1.402" "1.341" "1.503" "1.236" "170.2" "162.8" "160.8" "222.3" "192.9" "160.1" "238.5" "228.2" "255.7" "210.4" "" "" "" "" "" "" "" "" "" "" "159.5" "134.7" "149.3" "171.9" "164.4" "153.0" "217.9" "202.6" "255.7" "202.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7619751379045493323" "False" "High" "IsMasterProtein" "P04062" "Lysosomal acid glucosylceramidase OS=Homo sapiens OX=9606 GN=GBA1 PE=1 SV=3" "0.000" "False" "13.219" "8" "5" "6" "5" "536" "59.7" "7.61" "16.48" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "signal transduction activity or receptor binding;other molecular function" "Pf02055, Pf17189" "2629" "ENSG00000177628" "GBA1" "A8K796; B7Z5G2; B7Z6S1; hsa:2629; J3KQG4; J3KQK9; P04062; Q16545; Q4VX22; Q6I9R6; Q9UMJ8" "Sphingolipid pathway" "Association of TriC/CCT with target proteins during biosynthesis; Glycosphingolipid catabolism" "3" "0" "0.900" "1.016" "1.014" "1.044" "0.914" "0.935" "0.983" "0.955" "0.963" "182.2" "164.0" "185.1" "184.7" "190.3" "166.6" "170.5" "179.1" "174.0" "175.5" "" "" "" "" "" "" "" "" "" "" "170.7" "135.7" "171.9" "142.8" "162.2" "159.2" "155.8" "159.0" "174.0" "169.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6384522747761550778" "False" "High" "IsMasterProtein" "Q9NUP7" "tRNA:m(4)X modification enzyme TRM13 homolog OS=Homo sapiens OX=9606 GN=TRMT13 PE=1 SV=2" "0.000" "False" "13.213" "9" "5" "5" "5" "481" "54.2" "8.09" "12.96" "5" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf05206, Pf05253, Pf11722" "54482" "ENSG00000122435" "TRMT13" "hsa:54482; Q5VVL0; Q9NUP7; Q9NW65" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.988" "1.004" "1.075" "1.015" "0.977" "1.001" "0.996" "0.959" "0.994" "531.8" "525.5" "533.7" "571.6" "539.9" "519.7" "532.5" "529.6" "509.8" "528.8" "" "" "" "" "" "" "" "" "" "" "498.3" "434.8" "495.5" "441.9" "460.2" "496.5" "486.6" "470.2" "509.8" "509.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-32150545336103988" "False" "High" "IsMasterProtein" "Q14687" "Genetic suppressor element 1 OS=Homo sapiens OX=9606 GN=GSE1 PE=1 SV=3" "0.000" "False" "13.210" "4" "5" "5" "5" "1217" "136.1" "7.74" "12.40" "5" "" "" "" "Pf12540" "23199" "ENSG00000131149" "GSE1" "D3DUM4; hsa:23199; Q14687; Q8IY61; Q96GA4; Q9BW09" "" "" "0" "0" "1.018" "0.979" "1.011" "0.988" "0.977" "1.077" "0.992" "0.972" "1.029" "505.6" "514.9" "494.8" "510.9" "499.7" "494.0" "544.4" "501.8" "491.4" "520.2" "" "" "" "" "" "" "" "" "" "" "473.7" "426.1" "459.3" "395.0" "425.9" "472.0" "497.4" "445.5" "491.4" "500.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5265324397927722466" "False" "High" "IsMasterProtein" "Q6PIW4" "Fidgetin-like protein 1 OS=Homo sapiens OX=9606 GN=FIGNL1 PE=1 SV=2" "0.000" "False" "13.206" "8" "5" "5" "3" "674" "74.0" "7.85" "16.28" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00004, Pf09336, Pf17862" "63979" "ENSG00000132436" "FIGNL1" "D3DVM6; hsa:63979; Q6PIW4; Q86V18; Q8ND59; Q9H8P1; Q9H917" "" "" "0" "0" "1.140" "0.932" "1.197" "1.139" "1.061" "1.081" "1.027" "1.052" "1.116" "126.3" "144.0" "117.7" "151.2" "143.8" "134.0" "136.6" "129.7" "132.9" "140.9" "" "" "" "" "" "" "" "" "" "" "118.3" "119.1" "109.3" "116.9" "122.6" "128.0" "124.8" "115.1" "132.9" "135.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3678335116251458371" "False" "High" "IsMasterProtein" "P22670" "MHC class II regulatory factor RFX1 OS=Homo sapiens OX=9606 GN=RFX1 PE=1 SV=2" "0.000" "False" "13.203" "5" "4" "4" "4" "979" "104.7" "6.29" "14.87" "4" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257, Pf04589" "5989" "ENSG00000132005; ENSG00000288283" "RFX1" "hsa:5989; P22670" "Alstrom syndrome" "" "1" "0" "0.889" "0.956" "0.982" "0.957" "1.030" "0.965" "0.991" "1.144" "0.943" "108.5" "96.5" "103.7" "106.5" "103.8" "111.7" "104.7" "107.5" "124.2" "102.3" "" "" "" "" "" "" "" "" "" "" "101.7" "79.8" "96.3" "82.4" "88.5" "106.7" "95.7" "95.4" "124.2" "98.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9062296513815087799" "False" "High" "IsMasterProtein" "O14640" "Segment polarity protein dishevelled homolog DVL-1 OS=Homo sapiens OX=9606 GN=DVL1 PE=1 SV=2" "0.000" "False" "13.202" "7" "5" "6" "1" "695" "75.1" "7.81" "15.17" "5" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00595, Pf00610, Pf00778, Pf02377, Pf12316" "1855" "ENSG00000107404" "DVL1" "hsa:1855; O14640; Q5TA33; Q5TA35" "MicroRNAs in cardiomyocyte hypertrophy; Microtubule cytoskeleton regulation; Alzheimer's disease and miRNA effects; Neural crest differentiation; Adipogenesis; Notch signaling; Wnt signaling pathway; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Joubert syndrome; Pleural mesothelioma; Alzheimer's disease; 1p36 copy number variation syndrome; DNA damage response (only ATM dependent)" "Degradation of DVL; RHO GTPases Activate Formins; WNT mediated activation of DVL; PCP/CE pathway; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping" "28" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8718473415120973367" "False" "High" "IsMasterProtein" "O00462" "Beta-mannosidase OS=Homo sapiens OX=9606 GN=MANBA PE=1 SV=3" "0.000" "False" "13.193" "6" "6" "6" "5" "879" "100.8" "5.52" "14.24" "6" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf02836, Pf17753, Pf17786" "4126" "ENSG00000109323" "MANBA" "hsa:4126; O00462; Q96BC3; Q9NYX9" "" "Neutrophil degranulation; Lysosomal oligosaccharide catabolism" "2" "0" "0.918" "0.959" "0.904" "0.964" "0.993" "0.945" "0.969" "0.963" "0.945" "784.3" "719.6" "752.3" "708.7" "756.1" "779.0" "741.2" "759.8" "755.1" "741.2" "" "" "" "" "" "" "" "" "" "" "734.9" "595.5" "698.4" "547.9" "644.5" "744.2" "677.3" "674.6" "755.1" "713.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "756136000491077603" "False" "High" "IsMasterProtein" "P08236" "Beta-glucuronidase OS=Homo sapiens OX=9606 GN=GUSB PE=1 SV=2" "0.000" "False" "13.192" "7" "6" "7" "6" "651" "74.7" "7.02" "21.28" "6" "protein metabolism;other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00703, Pf02836, Pf02837" "2990" "ENSG00000169919" "GUSB" "B4E1F6; E9PCV0; hsa:2990; P08236; Q549U0; Q96CL9" "Glycosaminoglycan degradation" "Neutrophil degranulation; HS-GAG degradation; Hyaluronan uptake and degradation; MPS VII - Sly syndrome" "5" "0" "1.008" "0.978" "1.052" "1.011" "1.054" "0.968" "0.990" "0.902" "0.938" "892.9" "900.1" "873.3" "939.2" "902.4" "941.3" "864.5" "883.7" "805.8" "837.2" "" "" "" "" "" "" "" "" "" "" "836.6" "744.8" "810.8" "726.1" "769.2" "899.4" "789.9" "784.7" "805.8" "806.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "598569642609282214" "False" "High" "IsMasterProtein" "Q9BRS2" "Serine/threonine-protein kinase RIO1 OS=Homo sapiens OX=9606 GN=RIOK1 PE=1 SV=2" "0.000" "False" "13.166" "6" "4" "5" "4" "568" "65.5" "6.19" "14.51" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01163" "83732" "ENSG00000124784" "RIOK1" "B2RB28; Q8NDC8; Q96NV9; Q9BRS2" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.023" "0.921" "0.976" "0.993" "0.917" "0.933" "0.916" "0.935" "0.967" "682.6" "698.0" "628.7" "666.1" "677.7" "626.2" "636.8" "625.0" "638.0" "660.2" "" "" "" "" "" "" "" "" "" "" "639.6" "577.6" "583.6" "514.9" "577.6" "598.2" "581.8" "555.0" "638.0" "635.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-163153293796965969" "False" "High" "IsMasterProtein" "Q9NWB6" "Arginine and glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=ARGLU1 PE=1 SV=1" "0.000" "False" "13.132" "16" "6" "6" "6" "273" "33.2" "10.35" "18.28" "6" "" "cytosol;mitochondrion;nucleus" "" "Pf15346" "55082" "ENSG00000134884" "ARGLU1" "B4E0Y3; hsa:55082; Q5T257; Q6IQ34; Q9NWB6" "" "" "0" "0" "1.187" "1.035" "1.044" "0.955" "0.967" "1.035" "0.996" "1.095" "0.992" "599.9" "712.0" "620.9" "626.3" "572.8" "579.8" "620.9" "597.8" "657.2" "594.9" "" "" "" "" "" "" "" "" "" "" "562.1" "589.2" "576.4" "484.2" "488.2" "554.0" "567.3" "530.8" "657.2" "572.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2014587900474496052" "False" "High" "IsMasterProtein" "Q9P015" "Large ribosomal subunit protein uL15m OS=Homo sapiens OX=9606 GN=MRPL15 PE=1 SV=1" "0.000" "False" "13.130" "15" "4" "5" "4" "296" "33.4" "10.01" "15.14" "4" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00828" "29088" "ENSG00000137547" "MRPL15" "hsa:29088; Q96Q54; Q9H0Y1; Q9P015" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.086" "0.928" "1.174" "1.130" "1.075" "1.052" "1.076" "1.014" "1.033" "167.4" "181.8" "155.3" "196.4" "189.1" "179.9" "176.2" "180.2" "169.7" "172.9" "" "" "" "" "" "" "" "" "" "" "156.8" "150.5" "144.2" "151.9" "161.2" "171.9" "161.0" "160.0" "169.7" "166.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3545967028758689053" "False" "High" "IsMasterProtein" "P36543" "V-type proton ATPase subunit E 1 OS=Homo sapiens OX=9606 GN=ATP6V1E1 PE=1 SV=1" "0.000" "False" "13.124" "19" "5" "8" "5" "226" "26.1" "8.00" "19.87" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf01991" "529" "ENSG00000131100" "ATP6V1E1" "A8MUE4; A8MUN4; hsa:529; P36543" "VEGFA-VEGFR2 signaling; Proximal tubule transport" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "7" "0" "1.024" "0.989" "0.947" "1.018" "1.139" "0.944" "1.007" "0.974" "1.037" "398.0" "407.4" "393.5" "376.9" "405.2" "453.5" "375.9" "400.7" "387.6" "412.6" "" "" "" "" "" "" "" "" "" "" "372.9" "337.1" "365.3" "291.3" "345.4" "433.3" "343.4" "355.8" "387.6" "397.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9194436757358923865" "False" "High" "IsMasterProtein" "Q5W0V3" "FHF complex subunit HOOK interacting protein 2A OS=Homo sapiens OX=9606 GN=FHIP2A PE=1 SV=1" "0.000" "False" "13.108" "6" "5" "5" "5" "765" "86.5" "5.29" "13.98" "5" "" "" "" "Pf10257, Pf19311, Pf19314" "57700" "ENSG00000151553" "FHIP2A" "Q5H9P7; Q5W0V2; Q5W0V3; Q8IY76; Q9HCH2" "" "" "0" "0" "1.085" "1.019" "1.109" "1.075" "1.017" "1.012" "1.043" "0.984" "1.023" "679.1" "737.1" "692.3" "752.9" "730.2" "690.6" "687.5" "708.5" "668.2" "694.4" "" "" "" "" "" "" "" "" "" "" "636.3" "610.0" "642.7" "582.0" "622.4" "659.8" "628.2" "629.0" "668.2" "668.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5593923735961542225" "False" "High" "IsMasterProtein" "Q9BRG1" "Vacuolar protein-sorting-associated protein 25 OS=Homo sapiens OX=9606 GN=VPS25 PE=1 SV=1" "0.000" "False" "13.108" "29" "4" "5" "4" "176" "20.7" "6.34" "16.45" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05871" "84313" "ENSG00000131475" "VPS25" "B2R581; hsa:84313; Q9BRG1" "" "Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events" "2" "0" "1.086" "0.957" "1.098" "1.045" "0.995" "1.088" "1.049" "0.986" "1.046" "164.5" "178.7" "157.4" "180.6" "171.8" "163.7" "179.0" "172.4" "162.1" "171.9" "" "" "" "" "" "" "" "" "" "" "154.1" "147.8" "146.1" "139.6" "146.5" "156.4" "163.6" "153.1" "162.1" "165.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4271689599031996441" "False" "High" "IsMasterProtein" "Q9H1K1" "Iron-sulfur cluster assembly enzyme ISCU OS=Homo sapiens OX=9606 GN=ISCU PE=1 SV=2" "0.000" "False" "13.108" "24" "5" "7" "5" "167" "18.0" "9.48" "20.56" "5" "cell organization and biogenesis;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01592" "23479" "ENSG00000136003" "ISCU" "hsa:23479; Q6P713; Q99617; Q9H1K1; Q9H1K2" "Iron-sulfur cluster biogenesis" "Maturation of replicase proteins" "2" "0" "1.043" "0.991" "0.969" "0.982" "1.010" "0.977" "1.016" "0.943" "0.957" "1311.7" "1368.5" "1299.5" "1271.4" "1287.9" "1324.6" "1281.4" "1332.7" "1236.7" "1254.9" "" "" "" "" "" "" "" "" "" "" "1229.1" "1132.4" "1206.4" "982.9" "1097.8" "1265.6" "1170.8" "1183.3" "1236.7" "1208.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8978349436204480078" "False" "High" "IsMasterProtein" "Q13148" "TAR DNA-binding protein 43 OS=Homo sapiens OX=9606 GN=TARDBP PE=1 SV=1" "0.000" "False" "13.088" "13" "5" "6" "5" "414" "44.7" "6.19" "18.80" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf18694, Pf20910" "23435" "ENSG00000120948" "TARDBP" "A4GUK4; A4GUK5; A4GUK6; B2R629; B4DJ45; E2PU12; hsa:23435; Q13148; Q53H27; Q6FI92; Q96DJ0" "MECP2 and associated Rett syndrome; HDAC6 interactions in the central nervous system" "" "2" "0" "1.062" "0.986" "0.990" "0.955" "1.040" "0.945" "0.930" "0.901" "1.003" "1780.0" "1890.1" "1755.0" "1762.7" "1699.3" "1851.1" "1682.8" "1656.2" "1604.4" "1786.1" "" "" "" "" "" "" "" "" "" "" "1667.9" "1564.0" "1629.3" "1362.6" "1448.5" "1768.6" "1537.6" "1470.5" "1604.4" "1719.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6076863243069163850" "False" "High" "IsMasterProtein" "Q8WX93" "Palladin OS=Homo sapiens OX=9606 GN=PALLD PE=1 SV=3" "0.000" "False" "13.082" "3" "4" "4" "4" "1383" "150.5" "7.09" "14.34" "4" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf07679" "23022" "ENSG00000129116" "PALLD" "B3KTG2; B5MD56; B7ZMM5; hsa:23022; Q7L3E0; Q7Z3W0; Q86WE8; Q8N1M2; Q8WX93; Q9UGA0; Q9UQF5; Q9Y2J6; Q9Y3E9" "" "" "0" "0" "0.999" "1.103" "1.086" "1.111" "1.103" "1.056" "1.169" "1.105" "1.070" "293.6" "293.4" "323.8" "319.0" "326.2" "323.7" "310.0" "343.2" "324.6" "314.1" "" "" "" "" "" "" "" "" "" "" "275.1" "242.8" "300.6" "246.6" "278.1" "309.3" "283.3" "304.8" "324.6" "302.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-789511479774361380" "False" "High" "IsMasterProtein" "Q14202" "Zinc finger MYM-type protein 3 OS=Homo sapiens OX=9606 GN=ZMYM3 PE=1 SV=2" "0.000" "False" "13.081" "4" "5" "5" "4" "1370" "152.3" "6.35" "12.72" "5" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06467, Pf12012" "9203" "ENSG00000147130" "ZMYM3" "D3DVV3; hsa:9203; O15089; Q14202; Q96E26" "Orexin receptor pathway" "" "1" "0" "1.014" "1.117" "1.109" "1.066" "1.180" "1.170" "0.950" "1.046" "1.182" "138.4" "140.2" "154.6" "153.4" "147.4" "163.2" "161.9" "131.4" "144.7" "163.5" "" "" "" "" "" "" "" "" "" "" "129.6" "116.0" "143.5" "118.6" "125.7" "156.0" "148.0" "116.7" "144.7" "157.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "193140464994973163" "False" "High" "IsMasterProtein" "P49711" "Transcriptional repressor CTCF OS=Homo sapiens OX=9606 GN=CTCF PE=1 SV=1" "0.000" "False" "13.068" "6" "5" "7" "5" "727" "82.7" "6.96" "18.90" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "10664" "ENSG00000102974" "CTCF" "B5MC38; hsa:10664; P49711; Q53XI7; Q59EL8" "MECP2 and associated Rett syndrome; Prion disease pathway; Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors; Sudden infant death syndrome (SIDS) susceptibility pathways" "Activation of anterior HOX genes in hindbrain development during early embryogenesis" "5" "0" "1.024" "1.085" "0.948" "1.005" "0.954" "0.907" "0.900" "0.935" "1.020" "98.3" "100.7" "106.6" "93.3" "98.8" "93.8" "89.2" "88.4" "91.9" "100.3" "" "" "" "" "" "" "" "" "" "" "92.1" "83.3" "99.0" "72.1" "84.2" "89.6" "81.5" "78.5" "91.9" "96.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7726317818688943966" "False" "High" "IsMasterProtein" "Q9NQC3" "Reticulon-4 OS=Homo sapiens OX=9606 GN=RTN4 PE=1 SV=2" "0.000" "False" "13.050" "4" "5" "5" "5" "1192" "129.9" "4.50" "16.02" "5" "cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02453" "57142" "ENSG00000115310" "RTN4" "O94962; Q7L7Q5; Q7L7Q6; Q7L7Q8; Q8IUA4; Q96B16; Q9BXG5; Q9H212; Q9H3I3; Q9NQC3; Q9UQ42; Q9Y293; Q9Y2Y7; Q9Y5U6" "Alzheimer's disease and miRNA effects; Spinal cord injury; 22q11.2 copy number variation syndrome; Alzheimer's disease; Neurogenesis regulation in the olfactory epithelium; 13q12.12 copy number variation" "Axonal growth inhibition (RHOA activation)" "7" "0" "1.052" "1.027" "1.046" "1.090" "1.079" "0.990" "0.941" "0.926" "1.010" "383.0" "403.0" "393.4" "400.6" "417.6" "413.2" "379.2" "360.2" "354.5" "386.8" "" "" "" "" "" "" "" "" "" "" "358.8" "333.5" "365.2" "309.7" "355.9" "394.8" "346.5" "319.8" "354.5" "372.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5155365173843636052" "False" "High" "IsMasterProtein" "P48507" "Glutamate--cysteine ligase regulatory subunit OS=Homo sapiens OX=9606 GN=GCLM PE=1 SV=1" "0.000" "False" "13.043" "18" "4" "4" "4" "274" "30.7" "6.02" "14.35" "4" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00248" "2730" "ENSG00000023909" "GCLM" "A8K334; D3DT45; hsa:2730; M5A959; P48507; Q6FHC1; Q9NPX9; Q9NU74" "Glutathione metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Amino acid metabolism; One-carbon metabolism and related pathways; Ferroptosis; NRF2-ARE regulation; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway" "Glutathione synthesis and recycling; NFE2L2 regulating anti-oxidant/detoxification enzymes; Defective GCLC causes HAGGSD" "15" "0" "0.940" "0.971" "0.953" "1.024" "0.977" "0.977" "0.985" "0.969" "1.006" "697.7" "655.6" "677.3" "664.9" "714.2" "681.7" "681.5" "686.9" "676.1" "702.1" "" "" "" "" "" "" "" "" "" "" "653.7" "542.5" "628.8" "514.0" "608.8" "651.3" "622.7" "609.9" "676.1" "676.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1528073227460313936" "False" "High" "IsMasterProtein" "Q9H9T3" "Elongator complex protein 3 OS=Homo sapiens OX=9606 GN=ELP3 PE=1 SV=2" "0.000" "False" "13.035" "10" "5" "6" "5" "547" "62.2" "8.88" "16.15" "5" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf04055, Pf16199" "55140" "ENSG00000134014" "ELP3" "B4DE19; B4DIG1; E2QRI5; hsa:55140; Q53G84; Q6AWB0; Q9BVF7; Q9H9T3; Q9NVZ1" "Ethanol effects on histone modifications; HDAC6 interactions in the central nervous system" "HATs acetylate histones" "3" "0" "1.058" "1.025" "1.050" "1.041" "1.025" "0.998" "0.997" "0.975" "1.005" "463.0" "489.7" "474.6" "486.3" "482.2" "474.6" "462.1" "461.4" "451.2" "465.2" "" "" "" "" "" "" "" "" "" "" "433.8" "405.2" "440.6" "376.0" "411.0" "453.4" "422.2" "409.7" "451.2" "447.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5241124612822470915" "False" "High" "IsMasterProtein" "P36639" "Oxidized purine nucleoside triphosphate hydrolase OS=Homo sapiens OX=9606 GN=NUDT1 PE=1 SV=4" "0.000" "False" "13.034" "26" "3" "4" "3" "156" "17.9" "5.08" "14.04" "3" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "4521" "ENSG00000106268" "NUDT1" "A4D205; hsa:4521; P36639; Q6LES7; Q6P0Y6; Q7Z7N6; Q8IV95; Q9UBM0; Q9UBM9" "" "" "0" "0" "1.003" "0.957" "0.953" "0.896" "0.925" "0.910" "0.936" "0.903" "0.936" "601.1" "603.0" "575.1" "573.1" "538.5" "556.1" "546.8" "562.3" "542.7" "562.6" "" "" "" "" "" "" "" "" "" "" "563.2" "499.0" "533.9" "443.0" "459.0" "531.3" "499.6" "499.3" "542.7" "541.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2492705213444431370" "False" "High" "IsMasterProtein" "Q8TE04" "Pantothenate kinase 1 OS=Homo sapiens OX=9606 GN=PANK1 PE=1 SV=2" "0.000" "False" "13.023" "7" "5" "7" "5" "598" "64.3" "7.56" "15.05" "5" "other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf03630" "53354" "ENSG00000152782" "PANK1" "A6NIP0; hsa:53354; Q7RTX6; Q7Z495; Q8TBQ8; Q8TE04" "" "Coenzyme A biosynthesis" "1" "0" "0.901" "0.988" "1.028" "0.948" "0.991" "0.996" "0.963" "0.972" "0.988" "294.5" "265.4" "291.1" "302.7" "279.3" "292.0" "293.4" "283.7" "286.2" "291.0" "" "" "" "" "" "" "" "" "" "" "275.9" "219.6" "270.3" "234.0" "238.1" "278.9" "268.1" "251.9" "286.2" "280.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5208220757799786637" "False" "High" "IsMasterProtein" "Q9BTC8" "Metastasis-associated protein MTA3 OS=Homo sapiens OX=9606 GN=MTA3 PE=1 SV=2" "0.000" "False" "13.011" "8" "5" "6" "1" "594" "67.5" "8.57" "18.07" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "57504" "ENSG00000057935" "MTA3" "hsa:57504; Q9BTC8; Q9NSP2; Q9ULF4" "Pre-implantation embryo; Effect of progerin on genes involved in progeria" "Regulation of PTEN gene transcription; Potential therapeutics for SARS; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" "7" "0" "1.139" "1.181" "1.380" "1.264" "1.031" "1.161" "0.984" "0.967" "1.036" "54.7" "62.3" "64.5" "75.4" "69.1" "56.3" "63.5" "53.8" "52.9" "56.6" "" "" "" "" "" "" "" "" "" "" "51.2" "51.5" "59.9" "58.3" "58.9" "53.8" "58.0" "47.7" "52.9" "54.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7880237521652408093" "False" "High" "IsMasterProtein" "P15408" "Fos-related antigen 2 OS=Homo sapiens OX=9606 GN=FOSL2 PE=1 SV=1" "0.000" "False" "13.003" "18" "4" "5" "4" "326" "35.2" "7.49" "16.67" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "2355" "ENSG00000075426" "FOSL2" "B2RD58; B3KP27; B4DYV4; hsa:2355; P15408; Q6FG46" "Corticotropin-releasing hormone signaling pathway; Orexin receptor pathway; Osteoarthritic chondrocyte hypertrophy" "" "3" "0" "1.050" "1.006" "1.092" "1.057" "1.037" "1.062" "1.112" "1.044" "1.061" "492.3" "517.2" "495.3" "537.9" "520.5" "510.4" "523.0" "547.6" "514.1" "522.4" "" "" "" "" "" "" "" "" "" "" "461.3" "428.0" "459.8" "415.8" "443.7" "487.6" "477.9" "486.2" "514.1" "503.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2583602978446666213" "False" "High" "IsMasterProtein" "O15514" "DNA-directed RNA polymerase II subunit RPB4 OS=Homo sapiens OX=9606 GN=POLR2D PE=1 SV=1" "0.000" "False" "12.998" "35" "4" "4" "4" "142" "16.3" "4.79" "13.86" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf03874" "5433" "ENSG00000144231" "POLR2D" "hsa:5433; O15514; Q52LT4" "Pyrimidine metabolism" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "42" "0" "0.997" "0.928" "0.946" "0.839" "0.874" "0.927" "0.939" "0.997" "0.968" "121.2" "120.8" "112.5" "114.6" "101.7" "105.9" "112.3" "113.8" "120.8" "117.3" "" "" "" "" "" "" "" "" "" "" "113.5" "100.0" "104.4" "88.6" "86.6" "101.2" "102.6" "101.0" "120.8" "113.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2863197479310684416" "False" "High" "IsMasterProtein" "Q96EK6" "Glucosamine 6-phosphate N-acetyltransferase OS=Homo sapiens OX=9606 GN=GNPNAT1 PE=1 SV=1" "0.000" "False" "12.985" "27" "4" "6" "4" "184" "20.7" "7.99" "15.88" "4" "other metabolic processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00583" "64841" "ENSG00000100522" "GNPNAT1" "hsa:64841; Q96EK6" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "0" "0.917" "0.920" "1.000" "1.011" "0.972" "0.906" "1.042" "0.996" "1.011" "77.6" "71.2" "71.4" "77.7" "78.5" "75.4" "70.3" "80.9" "77.3" "78.5" "" "" "" "" "" "" "" "" "" "" "72.7" "58.9" "66.3" "60.0" "66.9" "72.1" "64.3" "71.8" "77.3" "75.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "415707649714952015" "False" "High" "IsMasterProtein" "P38398" "Breast cancer type 1 susceptibility protein OS=Homo sapiens OX=9606 GN=BRCA1 PE=1 SV=2" "0.000" "False" "12.985" "3" "5" "5" "5" "1863" "207.6" "5.41" "14.48" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00097, Pf00533, Pf12820" "672" "ENSG00000012048" "BRCA1" "E9PFZ0; hsa:672; O15129; P38398; Q1RMC1; Q3LRJ0; Q3LRJ6; Q6IN79; Q7KYU9" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; Glioblastoma signaling pathways; Hepatitis C and hepatocellular carcinoma; Pathways affected in adenoid cystic carcinoma; PI3K-Akt signaling pathway; Breast cancer pathway; DNA repair pathways, full network; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum ; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Primary ovarian insufficiency; 5q35 copy number variation; DNA damage response" "Meiotic synapsis; Resolution of D-loop Structures through Holliday Junction Intermediates; Neddylation; KEAP1-NFE2L2 pathway; SUMOylation of DNA damage response and repair proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Transcriptional Regulation by E2F6; Metalloprotease DUBs; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Nonhomologous End-Joining (NHEJ); Defective DNA double strand break response due to BRCA1 loss of function; Defective DNA double strand break response due to BARD1 loss of function" "40" "0" "1.003" "0.983" "0.982" "1.023" "0.962" "1.021" "1.023" "0.998" "1.020" "726.0" "728.0" "713.5" "712.6" "742.5" "698.7" "741.0" "742.4" "724.8" "740.9" "" "" "" "" "" "" "" "" "" "" "680.3" "602.4" "662.4" "550.9" "632.9" "667.6" "677.1" "659.2" "724.8" "713.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2379782774127482569" "False" "High" "IsMasterProtein" "Q86YM7" "Homer protein homolog 1 OS=Homo sapiens OX=9606 GN=HOMER1 PE=1 SV=2" "0.000" "False" "12.978" "13" "5" "5" "5" "354" "40.3" "5.44" "12.52" "5" "cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00568" "9456" "ENSG00000152413" "HOMER1" "B2R688; hsa:9456; O96003; Q86YM5; Q86YM7" "BDNF-TrkB signaling; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; Orexin receptor pathway; Cell lineage map for neuronal differentiation" "Neurexins and neuroligins" "7" "0" "1.062" "1.150" "1.293" "1.170" "0.992" "1.166" "1.047" "1.004" "1.132" "153.2" "162.7" "176.1" "198.0" "179.2" "151.9" "178.7" "160.3" "153.9" "173.4" "" "" "" "" "" "" "" "" "" "" "143.6" "134.6" "163.5" "153.1" "152.8" "145.2" "163.3" "142.4" "153.9" "167.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6953685933096655099" "False" "High" "IsMasterProtein" "Q8N465" "D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=D2HGDH PE=1 SV=3" "0.000" "False" "12.974" "8" "5" "5" "5" "521" "56.4" "7.99" "16.21" "5" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf01565, Pf02913" "728294" "ENSG00000180902" "D2HGDH" "B4E3L6; E7ENP2; hsa:728294; Q6IQ24; Q8N465; Q8N5Q8" "2q37 copy number variation syndrome" "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" "2" "0" "0.976" "1.011" "0.986" "1.010" "1.038" "0.943" "0.989" "1.021" "0.950" "922.2" "900.2" "932.5" "909.1" "931.7" "957.3" "869.3" "911.9" "941.1" "876.3" "" "" "" "" "" "" "" "" "" "" "864.1" "744.9" "865.7" "702.7" "794.1" "914.6" "794.3" "809.6" "941.1" "843.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4293780430971367314" "False" "High" "IsMasterProtein" "Q13371" "Phosducin-like protein OS=Homo sapiens OX=9606 GN=PDCL PE=1 SV=3" "0.000" "False" "12.958" "13" "4" "4" "4" "301" "34.3" "4.73" "14.00" "4" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf02114" "5082" "ENSG00000136940" "PDCL" "hsa:5082; Q13371; Q4VXB6; Q96AF1; Q9UEW7; Q9UFL0; Q9UNX1; Q9UNX2" "" "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" "1" "0" "0.976" "0.938" "0.919" "0.963" "0.970" "0.963" "0.952" "0.923" "0.904" "529.2" "516.5" "496.6" "486.4" "509.6" "513.3" "509.9" "503.7" "488.7" "478.6" "" "" "" "" "" "" "" "" "" "" "495.9" "427.4" "461.1" "376.0" "434.3" "490.5" "465.9" "447.2" "488.7" "460.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3330412660782960382" "False" "High" "IsMasterProtein" "Q16594" "Transcription initiation factor TFIID subunit 9 OS=Homo sapiens OX=9606 GN=TAF9 PE=1 SV=1" "0.000" "False" "12.956" "16" "4" "5" "4" "264" "29.0" "8.66" "11.02" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02291" "6880" "ENSG00000273841; ENSG00000276463" "TAF9" "D3DWA3; hsa:6880; Q16594; Q5U0D1; Q9BTS1" "Eukaryotic transcription initiation" "HATs acetylate histones; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "12" "0" "0.948" "0.896" "0.956" "0.913" "0.889" "0.903" "0.876" "0.792" "0.850" "436.1" "413.5" "390.7" "417.1" "397.9" "387.7" "394.0" "382.0" "345.5" "370.6" "" "" "" "" "" "" "" "" "" "" "408.6" "342.2" "362.7" "322.4" "339.2" "370.4" "360.0" "339.1" "345.5" "356.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7259467159663286133" "False" "High" "IsMasterProtein" "Q9Y5N6" "Origin recognition complex subunit 6 OS=Homo sapiens OX=9606 GN=ORC6 PE=1 SV=1" "0.000" "False" "12.951" "21" "6" "6" "6" "252" "28.1" "8.66" "14.87" "6" "DNA metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05460" "23594" "ENSG00000091651" "ORC6" "B3KN89; hsa:23594; Q9Y5N6" "Cell cycle; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Activation of the pre-replicative complex; Assembly of the ORC complex at the origin of replication; Activation of ATR in response to replication stress; E2F-enabled inhibition of pre-replication complex formation; CDC6 association with the ORC:origin complex" "10" "0" "0.997" "0.961" "0.987" "1.006" "1.044" "0.841" "0.872" "0.931" "0.970" "554.3" "552.8" "532.6" "547.1" "557.8" "578.9" "465.9" "483.5" "516.0" "537.5" "" "" "" "" "" "" "" "" "" "" "519.3" "457.4" "494.4" "422.9" "475.4" "553.1" "425.7" "429.3" "516.0" "517.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8095037981369694658" "False" "High" "IsMasterProtein" "P52434" "DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens OX=9606 GN=POLR2H PE=1 SV=4" "0.000" "False" "12.950" "31" "4" "6" "4" "150" "17.1" "4.68" "16.31" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03870" "5437" "ENSG00000163882" "POLR2H" "C9J413; C9JBJ6; C9JCU7; C9JUA8; hsa:5437; P52434; P53802; Q969R0" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "57" "0" "0.920" "1.106" "1.071" "1.014" "1.058" "1.097" "1.040" "1.112" "1.078" "342.7" "315.2" "379.0" "366.9" "347.6" "362.6" "375.8" "356.4" "381.1" "369.6" "" "" "" "" "" "" "" "" "" "" "321.1" "260.8" "351.8" "283.7" "296.3" "346.4" "343.4" "316.4" "381.1" "355.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7438852567896609676" "False" "High" "IsMasterProtein" "Q7L5N1" "COP9 signalosome complex subunit 6 OS=Homo sapiens OX=9606 GN=COPS6 PE=1 SV=1" "0.000" "False" "12.948" "14" "4" "6" "4" "327" "36.1" "5.73" "18.87" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01398, Pf13012" "10980" "ENSG00000168090" "COPS6" "A4D2A3; hsa:10980; O15387; Q7L5N1" "Nucleotide-binding oligomerization domain (NOD) pathway; Ciliary landscape" "DNA Damage Recognition in GG-NER; Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex" "6" "0" "1.018" "1.043" "1.005" "0.976" "1.056" "0.994" "1.030" "1.016" "1.033" "602.6" "613.5" "628.6" "605.7" "588.0" "636.2" "599.0" "620.4" "612.0" "622.6" "" "" "" "" "" "" "" "" "" "" "564.7" "507.6" "583.6" "468.2" "501.2" "607.8" "547.3" "550.9" "612.0" "599.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5155444033397587021" "False" "High" "IsMasterProtein" "Q06265" "Exosome complex component RRP45 OS=Homo sapiens OX=9606 GN=EXOSC9 PE=1 SV=3" "0.000" "False" "12.946" "9" "3" "4" "3" "439" "48.9" "5.29" "12.24" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "5393" "ENSG00000123737" "EXOSC9" "hsa:5393; Q06265; Q12883; Q4W5P5; Q86Y41; Q86Y48" "Ciliary landscape" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "7" "0" "1.093" "1.084" "1.216" "1.084" "1.062" "1.078" "1.080" "1.043" "1.015" "422.7" "462.2" "458.3" "514.1" "458.3" "448.9" "455.6" "456.6" "440.8" "428.9" "" "" "" "" "" "" "" "" "" "" "396.0" "382.4" "425.5" "397.4" "390.6" "428.9" "416.3" "405.4" "440.8" "412.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2282593962912776213" "False" "High" "IsMasterProtein" "Q15853" "Upstream stimulatory factor 2 OS=Homo sapiens OX=9606 GN=USF2 PE=1 SV=1" "0.000" "False" "12.940" "14" "5" "8" "5" "346" "36.9" "5.10" "15.49" "5" "transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "7392" "ENSG00000105698" "USF2" "hsa:7392; O00671; O00709; Q05750; Q07952; Q15851; Q15852; Q15853; Q6FI33; Q6YI47" "Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)" "Estrogen-dependent gene expression" "2" "0" "1.067" "0.960" "1.062" "1.035" "0.996" "0.995" "0.962" "0.930" "0.973" "227.4" "242.7" "218.4" "241.5" "235.3" "226.6" "226.3" "218.9" "211.6" "221.4" "" "" "" "" "" "" "" "" "" "" "213.1" "200.9" "202.8" "186.7" "200.6" "216.5" "206.7" "194.3" "211.6" "213.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3256219212228257535" "False" "High" "IsMasterProtein" "P15104" "Glutamine synthetase OS=Homo sapiens OX=9606 GN=GLUL PE=1 SV=4" "0.000" "False" "12.937" "12" "5" "8" "5" "373" "42.0" "6.89" "27.07" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00120, Pf03951" "2752" "ENSG00000135821" "GLUL" "hsa:2752; P15104; Q499Y9; Q5T9Z1; Q7Z3W4; Q8IZ17" "TNF-alpha signaling pathway; Amino acid metabolism; Cell lineage map for neuronal differentiation" "Glutamate and glutamine metabolism; Astrocytic Glutamate-Glutamine Uptake And Metabolism" "5" "0" "0.994" "1.043" "0.939" "1.056" "0.993" "0.945" "0.949" "1.029" "0.985" "481.6" "478.7" "502.3" "452.3" "508.4" "478.4" "455.1" "456.9" "495.5" "474.4" "" "" "" "" "" "" "" "" "" "" "451.2" "396.1" "466.3" "349.6" "433.3" "457.1" "415.9" "405.7" "495.5" "456.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2449426517635308859" "False" "High" "IsMasterProtein" "Q9H6F5" "Coiled-coil domain-containing protein 86 OS=Homo sapiens OX=9606 GN=CCDC86 PE=1 SV=1" "0.000" "False" "12.929" "16" "6" "6" "6" "360" "40.2" "10.33" "15.07" "6" "" "nucleus;other cell component" "" "Pf03879" "79080" "ENSG00000110104" "CCDC86" "B4DY99; hsa:79080; Q9H6F5" "" "" "0" "0" "1.069" "1.000" "1.003" "1.123" "1.046" "1.062" "1.172" "1.159" "1.102" "545.0" "582.6" "544.9" "546.6" "611.8" "570.1" "579.1" "639.0" "631.5" "600.9" "" "" "" "" "" "" "" "" "" "" "510.7" "482.1" "505.8" "422.5" "521.5" "544.7" "529.1" "567.3" "631.5" "578.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3028441251658952013" "False" "High" "IsMasterProtein" "Q9H7L9" "Sin3 histone deacetylase corepressor complex component SDS3 OS=Homo sapiens OX=9606 GN=SUDS3 PE=1 SV=2" "0.000" "False" "12.926" "13" "4" "5" "4" "328" "38.1" "5.66" "14.18" "4" "cell organization and biogenesis;other biological processes" "cytosol;nucleus" "other molecular function" "Pf08598" "64426" "ENSG00000111707" "SUDS3" "hsa:64426; Q4KMQ5; Q8N6H0; Q9H7L9; Q9H8D2" "" "NoRC negatively regulates rRNA expression; Ub-specific processing proteases; HDACs deacetylate histones; Potential therapeutics for SARS" "4" "0" "1.005" "0.953" "0.988" "1.094" "1.096" "1.068" "1.040" "1.011" "1.058" "154.0" "154.7" "146.7" "152.1" "168.5" "168.8" "164.4" "160.2" "155.7" "162.9" "" "" "" "" "" "" "" "" "" "" "144.3" "128.0" "136.2" "117.6" "143.6" "161.3" "150.2" "142.2" "155.7" "156.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6588464217400974604" "False" "High" "IsMasterProtein" "Q10471" "Polypeptide N-acetylgalactosaminyltransferase 2 OS=Homo sapiens OX=9606 GN=GALNT2 PE=1 SV=1" "0.000" "False" "12.925" "8" "4" "4" "4" "571" "64.7" "8.35" "13.11" "4" "protein metabolism;other metabolic processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00535, Pf00652" "2590" "ENSG00000143641" "GALNT2" "A8K1Y3; B7Z8V8; C5HU00; hsa:2590; Q10471; Q9NPY4" "" "COPI-independent Golgi-to-ER retrograde traffic; O-linked glycosylation of mucins" "2" "0" "1.011" "1.102" "1.046" "1.072" "1.127" "1.329" "1.515" "1.404" "1.183" "284.1" "287.3" "313.0" "297.3" "304.4" "320.2" "377.6" "430.3" "398.8" "336.1" "" "" "" "" "" "" "" "" "" "" "266.2" "237.7" "290.6" "229.8" "259.5" "305.9" "345.0" "382.0" "398.8" "323.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3289616204838975461" "False" "High" "IsMasterProtein" "P62851" "Small ribosomal subunit protein eS25 OS=Homo sapiens OX=9606 GN=RPS25 PE=1 SV=1" "0.000" "False" "12.923" "31" "4" "10" "4" "125" "13.7" "10.11" "29.63" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf03297" "6230" "ENSG00000118181; ENSG00000280831" "RPS25" "B2R4M7; hsa:6230; P25111; P62851" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "1.101" "1.117" "1.198" "1.087" "1.111" "1.325" "1.232" "1.143" "1.137" "666.4" "733.8" "744.3" "798.0" "724.4" "740.3" "883.2" "821.1" "761.6" "757.9" "" "" "" "" "" "" "" "" "" "" "624.4" "607.2" "691.0" "616.9" "617.4" "707.3" "807.0" "729.0" "761.6" "729.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7289415820017297402" "False" "High" "IsMasterProtein" "P82675" "Small ribosomal subunit protein uS5m OS=Homo sapiens OX=9606 GN=MRPS5 PE=1 SV=2" "0.000" "False" "12.896" "10" "5" "5" "5" "430" "48.0" "9.92" "10.76" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00333, Pf03719, Pf21251" "64969" "ENSG00000144029" "MRPS5" "hsa:64969; P82675; Q4ZFY5; Q96LJ6; Q9BWI4; Q9BYC4" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.217" "1.062" "1.177" "1.127" "1.049" "1.081" "0.981" "0.973" "1.029" "457.9" "557.3" "486.1" "538.7" "516.2" "480.1" "494.8" "449.0" "445.6" "471.2" "" "" "" "" "" "" "" "" "" "" "429.0" "461.1" "451.3" "416.5" "440.0" "458.7" "452.1" "398.7" "445.6" "453.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3568941862227660384" "False" "High" "IsMasterProtein" "Q9NVP2" "Histone chaperone ASF1B OS=Homo sapiens OX=9606 GN=ASF1B PE=1 SV=1" "0.000" "False" "12.892" "28" "4" "5" "3" "202" "22.4" "4.56" "15.20" "4" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04729" "55723" "ENSG00000105011; ENSG00000288210" "ASF1B" "hsa:55723; Q53G51; Q9NVP2; Q9NVZ0" "" "" "0" "1" "1.021" "1.120" "1.045" "1.118" "1.002" "1.074" "1.121" "1.111" "1.060" "304.6" "310.9" "341.3" "318.3" "340.4" "305.3" "327.0" "341.5" "338.4" "322.7" "" "" "" "" "" "" "" "" "" "" "285.4" "257.3" "316.8" "246.1" "290.2" "291.7" "298.8" "303.2" "338.4" "310.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3163566102457861060" "False" "High" "IsMasterProtein" "Q8IWI9" "MAX gene-associated protein OS=Homo sapiens OX=9606 GN=MGA PE=1 SV=4" "0.000" "False" "12.879" "2" "5" "5" "5" "3065" "336.0" "6.90" "13.72" "5" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf00907, Pf16059" "23269" "ENSG00000174197" "MGA" "B9EGR5; E7ENI0; F5H7K2; hsa:23269; Q8IWI9; Q9H8R3; Q9H9N7; Q9UG69; Q9Y4E9" "Pathways affected in adenoid cystic carcinoma" "Transcriptional Regulation by E2F6" "2" "0" "1.174" "0.962" "1.004" "1.167" "0.878" "1.173" "1.015" "0.948" "1.066" "55.5" "65.2" "53.4" "55.7" "64.8" "48.8" "65.1" "56.4" "52.6" "59.2" "" "" "" "" "" "" "" "" "" "" "52.0" "53.9" "49.6" "43.1" "55.2" "46.6" "59.5" "50.0" "52.6" "57.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7548254055495868617" "False" "High" "IsMasterProtein" "Q9BZD4" "Kinetochore protein Nuf2 OS=Homo sapiens OX=9606 GN=NUF2 PE=1 SV=2" "0.000" "False" "12.875" "10" "6" "6" "6" "464" "54.3" "8.27" "16.54" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03800" "83540" "ENSG00000143228" "NUF2" "hsa:83540; Q8WU69; Q96HJ4; Q96Q78; Q9BZD4" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.978" "0.999" "0.838" "0.938" "0.950" "0.795" "0.825" "0.879" "0.985" "1694.0" "1656.0" "1692.8" "1419.2" "1589.3" "1608.6" "1346.6" "1397.7" "1489.4" "1668.4" "" "" "" "" "" "" "" "" "" "" "1587.3" "1370.3" "1571.5" "1097.1" "1354.7" "1536.9" "1230.4" "1241.0" "1489.4" "1606.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9200993166108458048" "False" "High" "IsMasterProtein" "P29728" "2'-5'-oligoadenylate synthase 2 OS=Homo sapiens OX=9606 GN=OAS2 PE=1 SV=3" "0.000" "False" "12.867" "7" "5" "5" "5" "719" "82.4" "8.25" "17.45" "5" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01909, Pf10421" "4939" "ENSG00000111335" "OAS2" "A8K9T1; hsa:4939; P29728; Q6PJ33; Q86XX8" "Non-genomic actions of 1,25 dihydroxyvitamin D3; Measles virus infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction" "RSV-host interactions; OAS antiviral response; Interferon gamma signaling; Interferon alpha/beta signaling" "8" "0" "0.981" "1.100" "1.149" "1.088" "1.048" "1.067" "0.998" "0.945" "1.066" "440.8" "432.2" "484.7" "506.4" "479.6" "461.8" "470.5" "440.0" "416.4" "469.9" "" "" "" "" "" "" "" "" "" "" "413.0" "357.7" "450.0" "391.5" "408.8" "441.3" "429.9" "390.7" "416.4" "452.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5967874803311728941" "False" "High" "IsMasterProtein" "Q9UBP0" "Spastin OS=Homo sapiens OX=9606 GN=SPAST PE=1 SV=1" "0.000" "False" "12.863" "7" "5" "5" "4" "616" "67.2" "9.64" "15.67" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00004, Pf09336, Pf17862" "6683" "ENSG00000021574" "SPAST" "A7E2A7; hsa:6683; Q9UBP0; Q9UPR9" "" "Sealing of the nuclear envelope (NE) by ESCRT-III" "1" "1" "0.945" "0.987" "0.988" "0.955" "1.002" "0.985" "0.990" "0.923" "0.997" "764.1" "722.4" "754.4" "755.1" "730.1" "765.9" "752.5" "756.2" "705.1" "761.8" "" "" "" "" "" "" "" "" "" "" "716.0" "597.8" "700.4" "583.7" "622.3" "731.7" "687.5" "671.4" "705.1" "733.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6179011071974481602" "False" "High" "IsMasterProtein" "Q9NWS0" "PIH1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PIH1D1 PE=1 SV=1" "0.000" "False" "12.845" "11" "3" "4" "3" "290" "32.3" "5.14" "13.63" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08190, Pf18201" "55011" "ENSG00000104872" "PIH1D1" "B4DGN7; B4E2X7; hsa:55011; Q9BVL0; Q9NWS0" "" "" "0" "0" "1.112" "1.044" "1.126" "1.062" "1.016" "0.993" "1.050" "1.061" "1.062" "310.0" "344.9" "323.6" "349.2" "329.1" "315.0" "307.8" "325.6" "329.0" "329.2" "" "" "" "" "" "" "" "" "" "" "290.5" "285.4" "300.4" "270.0" "280.5" "301.0" "281.3" "289.1" "329.0" "317.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3703495334451703375" "False" "High" "IsMasterProtein" "O94782" "Ubiquitin carboxyl-terminal hydrolase 1 OS=Homo sapiens OX=9606 GN=USP1 PE=1 SV=1" "0.000" "False" "12.844" "6" "4" "5" "4" "785" "88.2" "5.45" "14.11" "4" "protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00443" "7398" "ENSG00000162607" "USP1" "A0PJ95; D3DQ57; hsa:7398; O94782; Q05BX7; Q59H66; Q9UFR0; Q9UNJ3" "miR-517 relationship with ARCN1 and USP1; DNA repair pathways, full network" "Fanconi Anemia Pathway; Recognition of DNA damage by PCNA-containing replication complex" "4" "0" "0.942" "1.038" "0.969" "0.994" "0.931" "0.974" "0.953" "1.076" "1.034" "216.3" "203.6" "224.5" "209.5" "214.9" "201.2" "210.7" "206.0" "232.7" "223.5" "" "" "" "" "" "" "" "" "" "" "202.6" "168.5" "208.4" "162.0" "183.1" "192.3" "192.5" "182.9" "232.7" "215.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5585916410181359903" "False" "High" "IsMasterProtein" "Q6IQ49" "Splicing regulator SDE2 OS=Homo sapiens OX=9606 GN=SDE2 PE=1 SV=1" "0.000" "False" "12.843" "12" "6" "8" "6" "451" "49.7" "6.05" "20.54" "6" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf13019, Pf13297" "163859" "ENSG00000143751" "SDE2" "A8K4P3; hsa:163859; Q5TD36; Q6IQ49; Q6ZS26; Q8NAG7" "" "mRNA Splicing - Major Pathway" "1" "0" "1.057" "0.957" "1.001" "1.024" "1.034" "1.106" "0.933" "1.053" "1.032" "313.7" "331.4" "300.1" "314.1" "321.3" "324.3" "346.9" "292.5" "330.2" "323.9" "" "" "" "" "" "" "" "" "" "" "293.9" "274.2" "278.6" "242.8" "273.9" "309.8" "317.0" "259.7" "330.2" "311.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6220946712320524294" "False" "High" "IsMasterProtein" "Q7L5D6" "Golgi to ER traffic protein 4 homolog OS=Homo sapiens OX=9606 GN=GET4 PE=1 SV=1" "0.000" "False" "12.833" "15" "4" "5" "4" "327" "36.5" "5.41" "10.41" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04190" "51608" "ENSG00000239857" "GET4" "A4D2Q1; B3KNC7; hsa:51608; Q7L5D6; Q9UFC9; Q9Y309" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "1.046" "1.042" "1.121" "1.066" "1.098" "1.105" "1.045" "1.077" "1.153" "241.8" "253.0" "251.9" "270.9" "257.7" "265.6" "267.2" "252.6" "260.4" "278.7" "" "" "" "" "" "" "" "" "" "" "226.5" "209.4" "233.9" "209.4" "219.6" "253.7" "244.1" "224.3" "260.4" "268.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4484612190120374131" "False" "High" "IsMasterProtein" "Q9Y6Y0" "Influenza virus NS1A-binding protein OS=Homo sapiens OX=9606 GN=IVNS1ABP PE=1 SV=3" "0.000" "False" "12.831" "9" "6" "6" "6" "642" "71.7" "5.53" "13.38" "6" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf00651, Pf01344, Pf07707" "10625" "ENSG00000116679" "IVNS1ABP" "A8K8R6; hsa:10625; Q1G4T6; Q1G4T7; Q5TF75; Q6NW38; Q7LCG2; Q9NZX0; Q9Y480; Q9Y6Y0" "" "" "0" "0" "0.953" "1.008" "0.900" "0.956" "1.001" "0.839" "0.844" "0.894" "0.933" "1553.2" "1481.0" "1565.6" "1398.5" "1484.7" "1554.9" "1302.9" "1311.4" "1387.8" "1449.9" "" "" "" "" "" "" "" "" "" "" "1455.4" "1225.5" "1453.5" "1081.1" "1265.6" "1485.6" "1190.5" "1164.4" "1387.8" "1396.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2471884395781023228" "False" "High" "IsMasterProtein" "Q9Y5X2" "Sorting nexin-8 OS=Homo sapiens OX=9606 GN=SNX8 PE=1 SV=1" "0.000" "False" "12.815" "9" "4" "4" "4" "465" "52.5" "7.39" "12.10" "4" "transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787, Pf19566" "29886" "ENSG00000106266" "SNX8" "A4D207; hsa:29886; Q96I67; Q9Y5X2" "" "" "0" "0" "1.006" "1.119" "1.188" "1.168" "1.100" "1.143" "1.161" "1.082" "1.120" "259.2" "260.9" "290.1" "308.0" "302.7" "285.1" "296.2" "300.9" "280.4" "290.4" "" "" "" "" "" "" "" "" "" "" "242.9" "215.9" "269.3" "238.1" "258.0" "272.4" "270.7" "267.2" "280.4" "279.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7211345083341158849" "False" "High" "IsMasterProtein" "Q15382" "GTP-binding protein Rheb OS=Homo sapiens OX=9606 GN=RHEB PE=1 SV=1" "0.000" "False" "12.806" "28" "6" "8" "6" "184" "20.5" "5.92" "24.23" "6" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00071" "6009" "ENSG00000106615" "RHEB" "B3KWN6; D3DX13; hsa:6009; Q15382; Q53Y56; Q99444" "Target of rapamycin signaling; Follicle stimulating hormone (FSH) signaling pathway; Polycystic kidney disease pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Joubert syndrome; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway" "mTORC1-mediated signalling; Macroautophagy; Regulation of PTEN gene transcription; Amino acids regulate mTORC1; TP53 Regulates Metabolic Genes; Energy dependent regulation of mTOR by LKB1-AMPK" "26" "0" "0.953" "0.989" "0.983" "0.978" "1.011" "0.989" "0.983" "0.947" "0.983" "1506.6" "1436.5" "1490.4" "1481.6" "1472.8" "1522.6" "1490.7" "1481.0" "1427.3" "1480.5" "" "" "" "" "" "" "" "" "" "" "1411.7" "1188.7" "1383.6" "1145.3" "1255.4" "1454.7" "1362.1" "1314.9" "1427.3" "1425.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1353658345851562217" "False" "High" "IsMasterProtein" "Q9BR76" "Coronin-1B OS=Homo sapiens OX=9606 GN=CORO1B PE=1 SV=1" "0.000" "False" "12.780" "9" "5" "5" "5" "489" "54.2" "5.88" "14.10" "5" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf16300" "57175" "ENSG00000172725" "CORO1B" "B2RD45; hsa:57175; Q9BR76" "" "" "0" "0" "1.034" "1.024" "1.052" "1.063" "1.035" "1.043" "1.036" "0.988" "1.036" "637.1" "658.6" "652.3" "670.1" "677.2" "659.3" "664.8" "659.9" "629.5" "660.2" "" "" "" "" "" "" "" "" "" "" "597.0" "545.0" "605.6" "518.0" "577.3" "629.9" "607.4" "585.9" "629.5" "635.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6990547013884615551" "False" "High" "IsMasterProtein" "Q5JSH3" "WD repeat-containing protein 44 OS=Homo sapiens OX=9606 GN=WDR44 PE=1 SV=1" "0.000" "False" "12.765" "5" "4" "5" "4" "913" "101.3" "5.45" "16.45" "4" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "54521" "ENSG00000131725" "WDR44" "B4DSE9; F8W913; hsa:54521; Q0JS52; Q0JTF3; Q5JSH2; Q5JSH3; Q6ZSC1; Q7Z365; Q7Z3P6; Q8NAU8; Q8NHU5; Q9NUV4" "Ectoderm differentiation" "" "1" "0" "1.078" "1.044" "1.059" "1.076" "1.042" "0.971" "0.902" "0.960" "1.049" "318.6" "343.5" "332.6" "337.4" "342.7" "331.9" "309.4" "287.4" "305.9" "334.2" "" "" "" "" "" "" "" "" "" "" "298.5" "284.3" "308.8" "260.8" "292.1" "317.1" "282.7" "255.2" "305.9" "321.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-320392191251803943" "False" "High" "IsMasterProtein" "Q9BXS6" "Nucleolar and spindle-associated protein 1 OS=Homo sapiens OX=9606 GN=NUSAP1 PE=1 SV=1" "0.000" "False" "12.755" "13" "5" "6" "5" "441" "49.4" "9.91" "17.64" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity" "Pf16006" "51203" "ENSG00000137804" "NUSAP1" "B4DDF1; E7ERR5; hsa:51203; J3KN21; Q53GW2; Q8TBT4; Q96E58; Q96FJ1; Q9BXS6; Q9GZM9; Q9NZ85; Q9UI70" "" "" "0" "0" "0.976" "1.053" "0.859" "0.863" "0.939" "0.921" "0.759" "0.920" "0.952" "606.7" "592.2" "639.1" "521.2" "523.7" "569.6" "558.5" "460.7" "558.4" "577.5" "" "" "" "" "" "" "" "" "" "" "568.5" "490.0" "593.4" "402.9" "446.4" "544.2" "510.3" "409.0" "558.4" "556.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7530688595643988973" "False" "High" "IsMasterProtein" "Q13510" "Acid ceramidase OS=Homo sapiens OX=9606 GN=ASAH1 PE=1 SV=5" "0.000" "False" "12.755" "13" "5" "7" "5" "395" "44.6" "7.62" "16.70" "5" "other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02275, Pf15508" "427" "ENSG00000104763" "ASAH1" "E9PDS0; hsa:427; Q13510; Q6W898; Q96AS2" "Sphingolipid pathway; S1P receptor signal transduction; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence; Biosynthesis and turnover of 1-deoxy-sphingoid bases; Synthesis of ceramides and 1-deoxyceramides" "Neutrophil degranulation; Glycosphingolipid catabolism" "8" "0" "1.008" "0.948" "1.010" "0.954" "1.060" "0.927" "0.950" "0.951" "0.971" "1094.9" "1103.9" "1037.7" "1106.1" "1044.5" "1160.9" "1014.5" "1040.1" "1040.9" "1063.4" "" "" "" "" "" "" "" "" "" "" "1025.9" "913.5" "963.4" "855.1" "890.3" "1109.1" "927.0" "923.5" "1040.9" "1023.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6460055541994458794" "False" "High" "IsMasterProtein" "Q14019" "Coactosin-like protein OS=Homo sapiens OX=9606 GN=COTL1 PE=1 SV=3" "0.000" "False" "12.747" "29" "5" "7" "5" "142" "15.9" "5.67" "19.14" "5" "cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "23406" "ENSG00000103187" "COTL1" "B2RDU3; D3DUL9; hsa:23406; Q14019; Q86XM5" "" "Neutrophil degranulation" "1" "0" "0.918" "0.915" "0.891" "0.929" "0.884" "0.905" "0.933" "0.880" "0.885" "896.6" "823.3" "820.0" "798.5" "832.8" "792.4" "811.9" "836.4" "789.2" "793.4" "" "" "" "" "" "" "" "" "" "" "840.2" "681.3" "761.3" "617.3" "709.8" "757.1" "741.9" "742.6" "789.2" "763.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6449517754761536848" "False" "High" "IsMasterProtein" "O95619" "YEATS domain-containing protein 4 OS=Homo sapiens OX=9606 GN=YEATS4 PE=1 SV=1" "0.000" "False" "12.745" "16" "4" "4" "4" "227" "26.5" "8.41" "13.08" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03366" "8089" "ENSG00000127337" "YEATS4" "hsa:8089; O95619; Q9NQD0" "" "HATs acetylate histones; Activation of the TFAP2 (AP-2) family of transcription factors" "2" "0" "1.007" "0.975" "0.987" "0.953" "0.983" "0.940" "0.952" "0.916" "0.952" "588.3" "592.1" "573.8" "580.4" "560.4" "578.1" "553.1" "560.0" "538.6" "560.2" "" "" "" "" "" "" "" "" "" "" "551.2" "490.0" "532.7" "448.7" "477.7" "552.3" "505.4" "497.2" "538.6" "539.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5375173174660804131" "False" "High" "IsMasterProtein" "Q16698" "2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial OS=Homo sapiens OX=9606 GN=DECR1 PE=1 SV=1" "0.000" "False" "12.739" "12" "4" "5" "4" "335" "36.0" "9.28" "14.65" "4" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf13561" "1666" "ENSG00000104325" "DECR1" "B7Z6B8; hsa:1666; Q16698; Q2M304; Q93085" "Fatty acid beta-oxidation; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling; Omega-6-fatty acids in senescence" "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" "5" "0" "1.077" "1.279" "1.297" "1.336" "1.177" "1.216" "1.242" "1.090" "1.320" "122.1" "131.6" "156.2" "158.4" "163.1" "143.7" "148.6" "151.7" "133.1" "161.2" "" "" "" "" "" "" "" "" "" "" "114.4" "108.9" "145.0" "122.5" "139.1" "137.3" "135.7" "134.7" "133.1" "155.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3729688095668830132" "False" "High" "IsMasterProtein" "O75419" "Cell division control protein 45 homolog OS=Homo sapiens OX=9606 GN=CDC45 PE=1 SV=1" "0.000" "False" "12.725" "8" "4" "5" "4" "566" "65.5" "5.53" "17.05" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf02724" "8318" "ENSG00000093009" "CDC45" "B4DDB4; B4DDU3; E9PDH7; hsa:8318; O60856; O75419; Q20WK8; Q6UW54; Q9UP68" "Cell cycle; Retinoblastoma gene in cancer; G1 to S cell cycle control; 22q11.2 copy number variation syndrome; DNA replication" "Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA; G1/S-Specific Transcription" "9" "0" "0.984" "1.038" "1.079" "1.008" "0.995" "1.050" "0.995" "0.950" "0.963" "360.6" "354.8" "374.5" "389.1" "363.5" "358.8" "378.8" "358.9" "342.5" "347.3" "" "" "" "" "" "" "" "" "" "" "337.9" "293.6" "347.7" "300.8" "309.8" "342.8" "346.1" "318.6" "342.5" "334.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8670958433918101160" "False" "High" "IsMasterProtein" "P26373" "Large ribosomal subunit protein eL13 OS=Homo sapiens OX=9606 GN=RPL13 PE=1 SV=4" "0.000" "False" "12.681" "17" "4" "4" "4" "211" "24.2" "11.65" "15.26" "4" "protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01294" "6137" "ENSG00000167526" "RPL13" "B4DLX3; F5H1S2; hsa:6137; P26373; Q3KQT8; Q567Q8; Q9BPX0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.002" "0.945" "0.905" "0.987" "0.913" "1.023" "0.956" "0.868" "0.985" "940.2" "941.9" "888.8" "850.9" "927.6" "858.9" "962.2" "898.6" "816.1" "926.2" "" "" "" "" "" "" "" "" "" "" "881.0" "779.4" "825.1" "657.7" "790.6" "820.6" "879.2" "797.9" "816.1" "891.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1820553366353762966" "False" "High" "IsMasterProtein" "Q9UKF7" "Cytoplasmic phosphatidylinositol transfer protein 1 OS=Homo sapiens OX=9606 GN=PITPNC1 PE=1 SV=3" "0.000" "False" "12.671" "14" "5" "5" "5" "332" "38.4" "6.40" "12.82" "5" "cell organization and biogenesis;transport;signal transduction" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf02121" "26207" "ENSG00000154217" "PITPNC1" "A8K473; hsa:26207; J3QR20; Q96I07; Q9UKF7" "" "" "0" "0" "1.062" "1.035" "1.172" "1.173" "1.068" "1.077" "1.049" "1.108" "1.123" "337.8" "358.6" "349.7" "395.8" "396.1" "360.8" "363.7" "354.5" "374.2" "379.4" "" "" "" "" "" "" "" "" "" "" "316.5" "296.8" "324.6" "306.0" "337.7" "344.7" "332.3" "314.7" "374.2" "365.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7197122219504261731" "False" "High" "IsMasterProtein" "Q96EK9" "Protein KTI12 homolog OS=Homo sapiens OX=9606 GN=KTI12 PE=1 SV=1" "0.000" "False" "12.659" "16" "4" "5" "4" "354" "38.6" "6.95" "16.85" "4" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf08433" "112970" "ENSG00000198841" "KTI12" "hsa:112970; Q96EK9" "" "" "0" "0" "1.005" "1.035" "1.121" "1.035" "1.018" "1.058" "1.004" "0.994" "1.031" "441.4" "443.6" "456.7" "495.0" "457.0" "449.2" "467.1" "443.1" "439.0" "454.9" "" "" "" "" "" "" "" "" "" "" "413.6" "367.1" "424.0" "382.6" "389.5" "429.1" "426.8" "393.5" "439.0" "438.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1224682826513998034" "False" "High" "IsMasterProtein" "O00255" "Menin OS=Homo sapiens OX=9606 GN=MEN1 PE=1 SV=5" "0.000" "False" "12.659" "8" "5" "6" "5" "610" "67.5" "6.55" "23.12" "5" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05053" "4221" "ENSG00000133895" "MEN1" "A5HBC6; A5HBC7; A5HBC8; A5HBC9; A5HBD0; A5HBD1; A5HBD2; O00255; O00632; Q9BUF0; Q9BUK2" "10q11.21q11.23 copy number variation syndrome" "RHO GTPases activate IQGAPs; Formation of WDR5-containing histone-modifying complexes; Formation of the beta-catenin:TCF transactivating complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "8" "0" "1.011" "1.054" "1.080" "1.090" "1.060" "1.055" "1.200" "1.088" "1.101" "918.8" "929.0" "968.6" "992.4" "1001.3" "973.7" "969.0" "1102.1" "999.9" "1011.3" "" "" "" "" "" "" "" "" "" "" "860.9" "768.7" "899.3" "767.2" "853.5" "930.3" "885.4" "978.6" "999.9" "973.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4838480320139969571" "False" "High" "IsMasterProtein" "Q13951" "Core-binding factor subunit beta OS=Homo sapiens OX=9606 GN=CBFB PE=1 SV=2" "0.000" "False" "12.650" "23" "4" "6" "4" "182" "21.5" "6.60" "22.27" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02312" "865" "ENSG00000067955" "CBFB" "A8K347; hsa:865; Q13124; Q13951; Q9HCT2" "Dual hijack model of Vif in HIV infection; Hijack of ubiquitination by SARS-CoV-2" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of RUNX3 expression and activity; RUNX2 regulates osteoblast differentiation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Estrogen-dependent gene expression; RUNX1 regulates expression of components of tight junctions; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; RUNX1 regulates estrogen receptor mediated transcription; RUNX1 regulates transcription of genes involved in WNT signaling; Transcriptional regulation of granulopoiesis; RUNX2 regulates genes involved in cell migration; RUNX3 regulates p14-ARF; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs); RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX2 regulates chondrocyte maturation; RUNX3 Regulates Immune Response and Cell Migration; Regulation of RUNX1 Expression and Activity; RUNX2 regulates genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in BCR signaling; RUNX3 regulates RUNX1-mediated transcription" "27" "0" "1.089" "1.028" "1.028" "1.100" "1.018" "1.137" "1.012" "1.011" "1.039" "235.6" "256.6" "242.1" "242.2" "259.1" "239.8" "267.9" "238.5" "238.2" "244.8" "" "" "" "" "" "" "" "" "" "" "220.7" "212.3" "224.7" "187.2" "220.9" "229.1" "244.8" "211.7" "238.2" "235.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "500960934407520232" "False" "High" "IsMasterProtein" "O43716" "Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial OS=Homo sapiens OX=9606 GN=GATC PE=1 SV=1" "0.000" "False" "12.645" "35" "4" "5" "4" "136" "15.1" "5.05" "11.45" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf02686" "283459" "ENSG00000257218" "GATC" "B3KSU7; hsa:283459; O43716; Q3B824; Q3KNR8" "" "" "0" "0" "1.058" "0.916" "0.992" "1.098" "1.045" "1.014" "1.016" "0.920" "0.994" "401.6" "424.9" "367.9" "398.3" "441.0" "419.9" "407.2" "408.1" "369.4" "399.2" "" "" "" "" "" "" "" "" "" "" "376.3" "351.6" "341.6" "307.9" "375.9" "401.2" "372.1" "362.4" "369.4" "384.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3065352799485715425" "False" "High" "IsMasterProtein" "Q9P0P0" "E3 ubiquitin-protein ligase RNF181 OS=Homo sapiens OX=9606 GN=RNF181 PE=1 SV=1" "0.000" "False" "12.643" "31" "5" "8" "5" "153" "17.9" "5.06" "17.69" "5" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf13639" "51255" "ENSG00000168894" "RNF181" "hsa:51255; Q53H81; Q9P0P0" "" "E3 ubiquitin ligases ubiquitinate target proteins" "1" "0" "1.044" "0.927" "0.964" "1.014" "1.067" "1.014" "0.930" "0.947" "1.026" "585.5" "611.1" "542.5" "564.6" "593.8" "624.5" "593.8" "544.4" "554.7" "600.4" "" "" "" "" "" "" "" "" "" "" "548.6" "505.7" "503.6" "436.5" "506.2" "596.6" "542.5" "483.4" "554.7" "578.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3265471816786777464" "False" "High" "IsMasterProtein" "Q9Y657" "Spindlin-1 OS=Homo sapiens OX=9606 GN=SPIN1 PE=1 SV=3" "0.000" "False" "12.636" "16" "3" "6" "3" "262" "29.6" "6.96" "17.09" "3" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf02513" "10927" "ENSG00000106723" "SPIN1" "A8K0X6; B3KRQ4; hsa:10927; Q7KZJ8; Q9GZT2; Q9H0N7; Q9Y657" "" "" "0" "0" "1.018" "1.010" "1.191" "1.074" "1.037" "0.947" "0.999" "0.991" "1.030" "265.0" "269.9" "267.8" "315.7" "284.5" "274.9" "251.1" "264.7" "262.7" "272.9" "" "" "" "" "" "" "" "" "" "" "248.3" "223.3" "248.6" "244.1" "242.5" "262.7" "229.4" "235.0" "262.7" "262.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4814601069630724909" "False" "High" "IsMasterProtein" "Q15906" "Vacuolar protein sorting-associated protein 72 homolog OS=Homo sapiens OX=9606 GN=VPS72 PE=1 SV=1" "0.000" "False" "12.624" "12" "4" "6" "4" "364" "40.6" "6.48" "18.01" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05764, Pf08265" "6944" "ENSG00000163159" "VPS72" "A6NLK9; A6PW55; hsa:6944; Q15906; Q53GJ2; Q5U0R4" "" "HATs acetylate histones" "1" "0" "0.976" "0.969" "0.911" "0.941" "1.036" "0.895" "0.916" "0.958" "1.015" "284.3" "277.4" "275.5" "259.0" "267.6" "294.6" "254.3" "260.3" "272.5" "288.4" "" "" "" "" "" "" "" "" "" "" "266.4" "229.5" "255.8" "200.2" "228.1" "281.5" "232.4" "231.2" "272.5" "277.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2194368294587715280" "False" "High" "IsMasterProtein" "Q16513" "Serine/threonine-protein kinase N2 OS=Homo sapiens OX=9606 GN=PKN2 PE=1 SV=1" "0.000" "False" "12.623" "5" "5" "5" "3" "984" "112.0" "6.30" "13.78" "5" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433, Pf02185" "5586" "ENSG00000065243" "PKN2" "B4DQ21; B4DTP5; B4DVG1; D3DT24; hsa:5586; Q08AF4; Q16513; Q9H1W4" "PI3K-Akt signaling pathway" "RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RHO GTPases activate PKNs" "6" "0" "1.070" "1.021" "1.074" "1.063" "1.055" "1.050" "1.045" "1.020" "1.009" "489.8" "524.3" "500.3" "526.0" "520.5" "516.7" "514.5" "511.8" "499.6" "494.3" "" "" "" "" "" "" "" "" "" "" "459.0" "433.8" "464.5" "406.6" "443.7" "493.7" "470.1" "454.5" "499.6" "475.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7697367026041443041" "False" "High" "IsMasterProtein" "Q96A49" "Synapse-associated protein 1 OS=Homo sapiens OX=9606 GN=SYAP1 PE=1 SV=1" "0.000" "False" "12.619" "14" "4" "5" "4" "352" "39.9" "4.53" "19.75" "4" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf03909" "94056" "ENSG00000169895" "SYAP1" "hsa:94056; Q68CP1; Q96A49; Q96C60; Q96JQ6; Q96T20" "" "" "0" "0" "1.147" "1.075" "1.209" "1.094" "1.151" "1.066" "1.066" "0.998" "1.098" "498.4" "571.5" "535.8" "602.7" "545.3" "573.8" "531.2" "531.4" "497.4" "547.5" "" "" "" "" "" "" "" "" "" "" "467.0" "472.9" "497.4" "465.9" "464.8" "548.2" "485.3" "471.8" "497.4" "527.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4669719094448447392" "False" "High" "IsMasterProtein" "Q9BSJ8" "Extended synaptotagmin-1 OS=Homo sapiens OX=9606 GN=ESYT1 PE=1 SV=1" "0.000" "False" "12.597" "4" "4" "4" "4" "1104" "122.8" "5.83" "13.36" "4" "cell organization and biogenesis;transport" "plasma membrane;other membranes;ER/Golgi" "transporter activity;other molecular function" "Pf00168, Pf17047" "23344" "ENSG00000139641" "ESYT1" "A0FGR7; A8K2S2; hsa:23344; O94848; Q6PJN4; Q9BSJ8; Q9H6J1; Q9H6W2; Q9Y416" "" "RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Glycosphingolipid transport; RHOD GTPase cycle; RHOF GTPase cycle" "7" "0" "1.100" "1.001" "1.218" "1.186" "1.103" "1.586" "1.529" "1.379" "1.213" "560.7" "616.8" "561.1" "682.8" "665.0" "618.6" "889.4" "857.3" "773.3" "679.8" "" "" "" "" "" "" "" "" "" "" "525.3" "510.4" "520.9" "527.8" "566.9" "591.0" "812.6" "761.2" "773.3" "654.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8976168612742678464" "False" "High" "IsMasterProtein" "Q13243" "Serine/arginine-rich splicing factor 5 OS=Homo sapiens OX=9606 GN=SRSF5 PE=1 SV=1" "0.000" "False" "12.582" "16" "4" "7" "3" "272" "31.2" "11.59" "19.79" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf00076" "6430" "ENSG00000100650" "SRSF5" "hsa:6430; O14797; Q13243; Q16662; Q49AD6; Q6FGE0" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "6" "0" "0.918" "1.018" "1.179" "1.024" "1.181" "1.020" "0.983" "0.925" "0.993" "120.7" "110.8" "122.8" "142.3" "123.7" "142.5" "123.1" "118.7" "111.6" "119.8" "" "" "" "" "" "" "" "" "" "" "113.1" "91.7" "114.0" "110.0" "105.4" "136.2" "112.5" "105.4" "111.6" "115.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2516739525907873838" "False" "High" "IsMasterProtein" "Q96RN5" "Mediator of RNA polymerase II transcription subunit 15 OS=Homo sapiens OX=9606 GN=MED15 PE=1 SV=2" "0.000" "False" "12.578" "7" "5" "10" "5" "788" "86.7" "9.42" "27.89" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09606, Pf21538, Pf21539" "51586" "ENSG00000099917" "MED15" "D3DX31; D3DX32; hsa:51586; O15413; Q6IC31; Q8NF16; Q96CT0; Q96IH7; Q96RN5; Q9P1T3" "Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; 22q11.2 copy number variation syndrome" "Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "7" "0" "0.911" "0.914" "0.938" "0.953" "0.909" "1.007" "0.941" "0.889" "0.902" "355.9" "324.4" "325.3" "333.8" "339.2" "323.5" "358.3" "334.9" "316.4" "321.1" "" "" "" "" "" "" "" "" "" "" "333.5" "268.4" "302.0" "258.0" "289.1" "309.1" "327.4" "297.4" "316.4" "309.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2429984818239481220" "False" "High" "IsMasterProtein" "O60488" "Long-chain-fatty-acid--CoA ligase 4 OS=Homo sapiens OX=9606 GN=ACSL4 PE=1 SV=2" "0.000" "False" "12.574" "6" "5" "5" "5" "711" "79.1" "8.38" "16.45" "5" "other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00501" "2182" "ENSG00000068366" "ACSL4" "D3DUY2; hsa:2182; O60488; O60848; O60849; Q5JWV8" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters; Mitochondrial fatty acid oxidation disorders" "Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion" "13" "0" "0.987" "0.957" "1.034" "0.897" "0.936" "0.883" "0.907" "0.890" "0.976" "611.4" "603.7" "585.3" "632.0" "548.2" "572.4" "539.6" "554.6" "544.1" "596.6" "" "" "" "" "" "" "" "" "" "" "572.9" "499.5" "543.3" "488.6" "467.2" "546.9" "493.1" "492.4" "544.1" "574.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3758284595644048114" "False" "High" "IsMasterProtein" "P78345" "Ribonuclease P protein subunit p38 OS=Homo sapiens OX=9606 GN=RPP38 PE=1 SV=2" "0.000" "False" "12.573" "13" "4" "4" "4" "283" "31.8" "9.92" "14.41" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01248" "10557" "ENSG00000152464" "RPP38" "B3KPY0; D3DRT8; hsa:10557; P78345; Q53F71; Q8NHS8" "Sphingolipid metabolism in senescence" "Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus" "3" "0" "1.017" "0.970" "0.965" "1.034" "1.137" "0.923" "1.033" "1.054" "1.101" "672.0" "683.3" "651.6" "648.2" "694.7" "763.9" "620.1" "694.4" "708.4" "739.6" "" "" "" "" "" "" "" "" "" "" "629.7" "565.4" "605.0" "501.1" "592.1" "729.8" "566.6" "616.6" "708.4" "712.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4257366520332167042" "False" "High" "IsMasterProtein" "Q13422" "DNA-binding protein Ikaros OS=Homo sapiens OX=9606 GN=IKZF1 PE=1 SV=1" "0.000" "False" "12.572" "8" "4" "6" "2" "519" "57.5" "6.58" "20.15" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "10320" "ENSG00000185811" "IKZF1" "A4D260; B4E0Z1; D3DVM5; hsa:10320; O00598; Q13422; Q53XL2; Q69BM4; Q8WVA3" "Hematopoietic stem cell differentiation; Development of pulmonary dendritic cells and macrophage subsets" "" "2" "0" "1.106" "0.950" "1.384" "1.093" "1.144" "1.301" "1.247" "1.155" "1.157" "147.9" "163.6" "140.5" "204.7" "161.7" "169.2" "192.4" "184.4" "170.8" "171.1" "" "" "" "" "" "" "" "" "" "" "138.5" "135.4" "130.4" "158.2" "137.8" "161.6" "175.8" "163.7" "170.8" "164.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4375562830836446683" "False" "High" "IsMasterProtein" "Q15386" "Ubiquitin-protein ligase E3C OS=Homo sapiens OX=9606 GN=UBE3C PE=1 SV=3" "0.000" "False" "12.568" "5" "5" "5" "5" "1083" "123.8" "6.71" "16.22" "5" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00632" "9690" "ENSG00000009335" "UBE3C" "A4D235; A6NCP3; hsa:9690; Q15386; Q8TC15; Q96CR4; Q9UDU3" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.026" "0.993" "1.064" "1.104" "1.033" "1.072" "0.979" "1.036" "1.036" "335.4" "344.2" "333.2" "357.0" "370.3" "346.4" "359.4" "328.4" "347.4" "347.5" "" "" "" "" "" "" "" "" "" "" "314.3" "284.8" "309.3" "276.0" "315.6" "330.9" "328.4" "291.6" "347.4" "334.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6527665309278316816" "False" "High" "IsMasterProtein" "O15145" "Actin-related protein 2/3 complex subunit 3 OS=Homo sapiens OX=9606 GN=ARPC3 PE=1 SV=3" "0.000" "False" "12.563" "17" "3" "8" "3" "178" "20.5" "8.59" "18.89" "3" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf04062" "10094" "ENSG00000111229" "ARPC3" "hsa:10094; O00554; O15145" "Pathogenic Escherichia coli infection" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "6" "0" "1.289" "1.114" "1.185" "1.208" "1.108" "1.089" "1.100" "1.296" "1.048" "680.3" "876.7" "757.8" "806.2" "822.1" "753.7" "740.7" "748.6" "881.3" "713.0" "" "" "" "" "" "" "" "" "" "" "637.4" "725.5" "703.5" "623.2" "700.7" "720.1" "676.8" "664.7" "881.3" "686.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1987024820899376297" "False" "High" "IsMasterProtein" "Q9BRA2" "Thioredoxin domain-containing protein 17 OS=Homo sapiens OX=9606 GN=TXNDC17 PE=1 SV=1" "0.000" "False" "12.553" "31" "4" "9" "4" "123" "13.9" "5.52" "23.83" "4" "signal transduction;other biological processes" "cytosol" "other molecular function" "Pf06110" "84817" "ENSG00000129235" "TXNDC17" "A8K7E8; hsa:84817; Q9BRA2" "" "" "0" "0" "0.984" "0.980" "0.992" "0.942" "0.922" "0.931" "0.978" "0.889" "0.888" "1515.5" "1491.1" "1484.6" "1502.7" "1427.7" "1396.6" "1411.1" "1482.0" "1347.3" "1346.4" "" "" "" "" "" "" "" "" "" "" "1420.0" "1233.9" "1378.3" "1161.7" "1217.0" "1334.3" "1289.4" "1315.8" "1347.3" "1296.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6104257487773187704" "False" "High" "IsMasterProtein" "Q0PNE2" "Elongator complex protein 6 OS=Homo sapiens OX=9606 GN=ELP6 PE=1 SV=1" "0.000" "False" "12.546" "16" "4" "5" "4" "266" "29.8" "6.84" "14.32" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf09807" "54859" "ENSG00000163832" "ELP6" "hsa:54859; Q0PNE2; Q9BW57; Q9NXJ3" "" "HATs acetylate histones" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1831448905794715132" "False" "High" "IsMasterProtein" "P84098" "Large ribosomal subunit protein eL19 OS=Homo sapiens OX=9606 GN=RPL19 PE=1 SV=1" "0.000" "False" "12.527" "24" "5" "8" "5" "196" "23.5" "11.47" "19.69" "5" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01280" "6143" "ENSG00000108298" "RPL19" "B2R4K2; P14118; P22908; P84098; Q502Y6; Q7Z6E4" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.074" "0.972" "1.088" "1.002" "1.073" "1.047" "1.070" "1.126" "1.038" "403.5" "433.4" "392.2" "438.9" "404.2" "432.9" "422.4" "431.8" "454.1" "418.8" "" "" "" "" "" "" "" "" "" "" "378.1" "358.6" "364.1" "339.3" "344.5" "413.6" "386.0" "383.4" "454.1" "403.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6138498598484703965" "False" "High" "IsMasterProtein" "P30405" "Peptidyl-prolyl cis-trans isomerase F, mitochondrial OS=Homo sapiens OX=9606 GN=PPIF PE=1 SV=1" "0.000" "False" "12.518" "20" "5" "9" "4" "207" "22.0" "9.38" "29.57" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00160" "10105" "ENSG00000108179" "PPIF" "hsa:10105; P30405; Q2YDB7; Q5W131" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "" "2" "0" "0.854" "0.967" "0.932" "0.931" "0.953" "0.942" "0.965" "0.867" "0.923" "999.7" "853.6" "966.6" "932.0" "930.9" "952.9" "942.0" "964.7" "866.4" "923.1" "" "" "" "" "" "" "" "" "" "" "936.7" "706.4" "897.3" "720.5" "793.5" "910.4" "860.7" "856.5" "866.4" "888.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5083710564544014092" "False" "High" "IsMasterProtein" "P84103" "Serine/arginine-rich splicing factor 3 OS=Homo sapiens OX=9606 GN=SRSF3 PE=1 SV=1" "0.000" "False" "12.506" "28" "5" "7" "5" "164" "19.3" "11.65" "22.55" "5" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6428" "ENSG00000112081" "SRSF3" "B4E241; hsa:6428; O08831; P23152; P84103; Q5R3K0" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "6" "0" "1.072" "1.168" "1.061" "1.141" "1.125" "1.136" "0.990" "1.118" "1.059" "918.3" "984.3" "1072.5" "974.2" "1047.6" "1033.5" "1042.7" "909.5" "1027.0" "972.6" "" "" "" "" "" "" "" "" "" "" "860.4" "814.5" "995.7" "753.1" "892.9" "987.4" "952.8" "807.5" "1027.0" "936.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "576551174696518957" "False" "High" "IsMasterProtein" "Q5T447" "E3 ubiquitin-protein ligase HECTD3 OS=Homo sapiens OX=9606 GN=HECTD3 PE=1 SV=1" "0.000" "False" "12.503" "5" "4" "4" "4" "861" "97.1" "5.64" "14.21" "4" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00632, Pf03256" "79654" "ENSG00000126107" "HECTD3" "B3KPV7; B3KRH4; hsa:79654; Q5T447; Q5T448; Q9H783" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.032" "0.989" "1.104" "1.083" "1.011" "0.991" "0.950" "0.990" "1.002" "568.8" "587.1" "562.6" "627.9" "615.8" "574.8" "563.5" "540.4" "563.2" "569.8" "" "" "" "" "" "" "" "" "" "" "532.9" "485.8" "522.3" "485.4" "524.9" "549.2" "514.8" "479.8" "563.2" "548.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4345096920380690584" "False" "High" "IsMasterProtein" "Q68CZ6" "HAUS augmin-like complex subunit 3 OS=Homo sapiens OX=9606 GN=HAUS3 PE=1 SV=1" "0.000" "False" "12.500" "7" "4" "6" "4" "603" "69.6" "5.55" "10.71" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf14932" "79441" "ENSG00000214367" "HAUS3" "B4DF64; hsa:79441; O43606; Q68CZ6; Q8TAZ5; Q9BTJ9" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "0.995" "0.967" "1.153" "1.060" "1.010" "1.055" "1.033" "0.941" "1.029" "310.1" "308.5" "299.7" "357.5" "328.6" "313.1" "327.2" "320.2" "291.9" "319.2" "" "" "" "" "" "" "" "" "" "" "290.5" "255.3" "278.2" "276.4" "280.1" "299.1" "299.0" "284.3" "291.9" "307.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2326963864063357056" "False" "High" "IsMasterProtein" "O95202" "Mitochondrial proton/calcium exchanger protein OS=Homo sapiens OX=9606 GN=LETM1 PE=1 SV=1" "0.000" "False" "12.499" "6" "5" "5" "5" "739" "83.3" "6.70" "11.82" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;translation activity;other molecular function" "Pf07766" "3954" "ENSG00000168924" "LETM1" "B4DED2; hsa:3954; O95202; Q9UF65" "4p16.3 copy number variation" "RHOG GTPase cycle; Mitochondrial calcium ion transport" "3" "0" "0.971" "0.974" "1.099" "1.090" "1.101" "1.316" "1.366" "1.228" "1.057" "704.2" "684.1" "686.1" "773.6" "767.3" "775.3" "926.8" "961.8" "864.6" "744.2" "" "" "" "" "" "" "" "" "" "" "659.9" "566.1" "637.0" "598.0" "654.0" "740.7" "846.9" "854.0" "864.6" "716.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5167676998188788346" "False" "High" "IsMasterProtein" "Q96EV2" "RNA-binding protein 33 OS=Homo sapiens OX=9606 GN=RBM33 PE=1 SV=3" "0.000" "False" "12.484" "4" "4" "4" "4" "1170" "129.9" "6.93" "13.25" "4" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "155435" "ENSG00000184863" "RBM33" "A4D244; B5MC24; hsa:155435; Q52LF5; Q75LN9; Q75ML5; Q96EV2; Q9NSV0" "" "" "0" "0" "1.024" "1.094" "1.048" "1.073" "1.255" "1.163" "1.086" "1.053" "1.107" "198.2" "202.8" "216.9" "207.7" "212.6" "248.7" "230.6" "215.2" "208.6" "219.5" "" "" "" "" "" "" "" "" "" "" "185.7" "167.9" "201.3" "160.6" "181.2" "237.6" "210.7" "191.1" "208.6" "211.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4871053517443562380" "False" "High" "IsMasterProtein" "P57772" "Selenocysteine-specific elongation factor OS=Homo sapiens OX=9606 GN=EEFSEC PE=1 SV=4" "0.000" "False" "12.460" "8" "5" "7" "5" "596" "65.3" "8.35" "20.25" "5" "protein metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144, Pf21131, Pf21208" "60678" "ENSG00000132394; ENSG00000284869" "EEFSEC" "hsa:60678; P57772; Q96HZ6" "Selenium metabolism and selenoproteins" "Selenocysteine synthesis" "2" "0" "1.028" "1.029" "1.078" "1.075" "1.071" "1.053" "1.051" "1.059" "1.076" "684.3" "703.6" "704.0" "737.4" "735.6" "733.1" "720.5" "719.1" "724.6" "736.1" "" "" "" "" "" "" "" "" "" "" "641.2" "582.2" "653.5" "570.0" "627.0" "700.4" "658.4" "638.5" "724.6" "708.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1195560165940606003" "False" "High" "IsMasterProtein" "Q9Y4X0" "Nuclear protein AMMECR1 OS=Homo sapiens OX=9606 GN=AMMECR1 PE=1 SV=1" "0.000" "False" "12.457" "11" "4" "4" "1" "333" "35.4" "8.63" "14.77" "4" "" "mitochondrion;nucleus" "" "Pf01871" "9949" "ENSG00000101935" "AMMECR1" "Q5JYV9; Q6P9D8; Q8WX22; Q9UIQ8; Q9Y4X0" "" "" "0" "0" "0.991" "0.952" "0.982" "0.984" "0.999" "0.894" "0.979" "0.971" "0.996" "290.6" "288.0" "276.6" "285.3" "285.9" "290.3" "259.7" "284.6" "282.2" "289.4" "" "" "" "" "" "" "" "" "" "" "272.3" "238.3" "256.8" "220.6" "243.7" "277.3" "237.3" "252.7" "282.2" "278.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6020211284576112703" "False" "High" "IsMasterProtein" "Q86UY8" "5'-nucleotidase domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NT5DC3 PE=1 SV=1" "0.000" "False" "12.449" "6" "4" "5" "4" "548" "63.4" "8.31" "13.24" "4" "" "cytosol;other cell component" "other molecular function" "Pf05761" "51559" "ENSG00000111696" "NT5DC3" "hsa:51559; Q86UY8; Q9NUM7; Q9P2T2; Q9P2T3" "" "" "0" "0" "1.041" "1.110" "1.128" "1.081" "1.012" "1.036" "1.067" "1.053" "1.035" "233.8" "243.4" "259.5" "263.8" "252.8" "236.6" "242.2" "249.6" "246.3" "242.0" "" "" "" "" "" "" "" "" "" "" "219.1" "201.4" "240.9" "203.9" "215.5" "226.0" "221.3" "221.6" "246.3" "233.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3530814954955127226" "False" "High" "IsMasterProtein" "Q9UKV0" "Histone deacetylase 9 OS=Homo sapiens OX=9606 GN=HDAC9 PE=1 SV=2" "0.000" "False" "12.446" "5" "5" "5" "5" "1011" "111.2" "6.89" "14.83" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00850, Pf12203" "9734" "ENSG00000048052" "HDAC9" "A7E2F3; B7Z4I4; B7Z917; B7Z928; B7Z940; C9JS87; E7EX34; F8W9E0; hsa:9734; O94845; O95028; Q2M2R6; Q86SL1; Q86US3; Q9UKV0" "MicroRNAs in cardiomyocyte hypertrophy; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; HDAC6 interactions in the central nervous system; Sudden infant death syndrome (SIDS) susceptibility pathways" "Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway" "12" "0" "1.094" "1.026" "1.080" "0.980" "0.932" "0.975" "0.887" "0.874" "0.882" "256.2" "280.5" "263.0" "276.8" "251.0" "238.7" "249.8" "227.2" "223.9" "225.9" "" "" "" "" "" "" "" "" "" "" "240.1" "232.1" "244.2" "214.0" "214.0" "228.1" "228.2" "201.8" "223.9" "217.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2548334964560567831" "False" "High" "IsMasterProtein" "Q9GZT8" "NIF3-like protein 1 OS=Homo sapiens OX=9606 GN=NIF3L1 PE=1 SV=2" "0.000" "False" "12.428" "12" "5" "7" "5" "377" "41.9" "6.65" "16.05" "5" "developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf01784" "60491" "ENSG00000196290" "NIF3L1" "hsa:60491; Q53TX4; Q6X735; Q9GZT8; Q9H2D2; Q9HC18" "" "" "0" "0" "1.005" "0.984" "1.009" "0.886" "0.917" "0.977" "0.866" "0.930" "0.921" "915.6" "920.4" "900.7" "923.6" "811.0" "839.4" "894.2" "793.2" "851.5" "843.3" "" "" "" "" "" "" "" "" "" "" "857.9" "761.6" "836.1" "714.0" "691.3" "802.0" "817.1" "704.3" "851.5" "811.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5846443296709188562" "False" "High" "IsMasterProtein" "Q9Y248" "DNA replication complex GINS protein PSF2 OS=Homo sapiens OX=9606 GN=GINS2 PE=1 SV=1" "0.000" "False" "12.419" "17" "3" "6" "3" "185" "21.4" "5.44" "18.56" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus" "" "Pf05916" "51659" "ENSG00000131153" "GINS2" "D3DUM5; hsa:51659; Q6IAG9; Q9Y248" "" "Unwinding of DNA" "1" "0" "0.945" "1.068" "1.070" "1.119" "1.202" "1.034" "1.087" "1.127" "1.156" "138.5" "130.9" "147.9" "148.2" "155.0" "166.5" "143.1" "150.5" "156.1" "160.0" "" "" "" "" "" "" "" "" "" "" "129.8" "108.3" "137.3" "114.6" "132.1" "159.1" "130.8" "133.6" "156.1" "154.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8250154090209623680" "False" "High" "IsMasterProtein" "Q9H2W6" "Large ribosomal subunit protein mL46 OS=Homo sapiens OX=9606 GN=MRPL46 PE=1 SV=1" "0.000" "False" "12.417" "14" "5" "7" "5" "279" "31.7" "7.05" "20.52" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "other molecular function" "Pf11788" "26589" "ENSG00000259494" "MRPL46" "B2RD75; hsa:26589; Q9H2W6; Q9HBU8" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.065" "1.047" "1.055" "1.134" "1.206" "1.128" "1.098" "1.134" "1.161" "659.2" "701.8" "690.1" "695.6" "747.9" "795.1" "743.5" "724.0" "747.7" "765.1" "" "" "" "" "" "" "" "" "" "" "617.7" "580.7" "640.7" "537.8" "637.4" "759.7" "679.4" "642.9" "747.7" "736.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5155041473924721713" "False" "High" "IsMasterProtein" "P48454" "Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform OS=Homo sapiens OX=9606 GN=PPP3CC PE=1 SV=3" "0.000" "False" "12.417" "8" "4" "9" "1" "512" "58.1" "6.98" "26.16" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00149" "5533" "ENSG00000120910" "PPP3CC" "B4DRT5; hsa:5533; P48454; Q9BSS6; Q9H4M5" "Energy metabolism; Alzheimer's disease and miRNA effects; Amyotrophic lateral sclerosis (ALS); Initiation of transcription and translation elongation at the HIV-1 LTR; G protein signaling pathways; MAPK signaling pathway; Wnt signaling; Alzheimer's disease; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "DARPP-32 events; Activation of BAD and translocation to mitochondria" "11" "0" "0.993" "0.953" "1.063" "1.004" "1.003" "1.025" "0.970" "1.041" "1.035" "187.3" "185.9" "178.5" "199.0" "188.1" "187.9" "192.0" "181.7" "194.9" "193.9" "" "" "" "" "" "" "" "" "" "" "175.5" "153.9" "165.7" "153.9" "160.3" "179.5" "175.5" "161.3" "194.9" "186.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-692133851352470930" "False" "High" "IsMasterProtein" "Q14376" "UDP-glucose 4-epimerase OS=Homo sapiens OX=9606 GN=GALE PE=1 SV=2" "0.000" "False" "12.414" "12" "4" "4" "4" "348" "38.3" "6.73" "13.18" "4" "other metabolic processes" "cytosol" "other molecular function" "Pf16363" "2582" "ENSG00000117308" "GALE" "A0A024RAH5; B3KQ39; hsa:2582; Q14376; Q38G75; Q86W41; Q9BVE3; Q9UJB4" "Disorders of galactose metabolism ; UDP-derived sugars synthesis in fibroblasts" "Galactose catabolism; Defective GALE causes EDG" "4" "0" "0.977" "0.965" "1.089" "0.988" "0.986" "1.005" "0.943" "0.965" "0.992" "384.3" "375.6" "370.7" "418.7" "379.7" "379.0" "386.2" "362.3" "371.0" "381.4" "" "" "" "" "" "" "" "" "" "" "360.1" "310.8" "344.2" "323.7" "323.6" "362.1" "352.9" "321.7" "371.0" "367.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5777002652342293914" "False" "High" "IsMasterProtein" "Q9H307" "Pinin OS=Homo sapiens OX=9606 GN=PNN PE=1 SV=5" "0.000" "False" "12.406" "7" "5" "5" "5" "717" "81.6" "7.14" "13.46" "5" "cell adhesion;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04696, Pf04697" "5411" "ENSG00000100941" "PNN" "B4DZX8; hsa:5411; O60899; Q53EM7; Q6P5X4; Q7KYL1; Q99738; Q9H307; Q9UHZ9; Q9UQR9" "" "mRNA Splicing - Major Pathway" "1" "0" "1.167" "1.101" "1.195" "1.089" "1.113" "1.132" "1.073" "1.038" "1.105" "520.4" "607.1" "572.8" "622.0" "566.7" "579.4" "589.2" "558.6" "540.1" "575.2" "" "" "" "" "" "" "" "" "" "" "487.6" "502.4" "531.8" "480.9" "483.0" "553.6" "538.4" "496.0" "540.1" "553.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1908958946430001431" "False" "High" "IsMasterProtein" "O60333" "Kinesin-like protein KIF1B OS=Homo sapiens OX=9606 GN=KIF1B PE=1 SV=5" "0.000" "False" "12.387" "2" "4" "5" "3" "1816" "204.3" "5.60" "16.91" "4" "cell-cell signaling;transport;other biological processes" "other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00225, Pf00498, Pf12423, Pf12473, Pf16183" "23095" "ENSG00000054523" "KIF1B" "A6NFS8; A6NKQ4; hsa:23095; O60333; Q4VXC3; Q4VXC4; Q4VXC5; Q4VXC6; Q96Q94; Q9BV80; Q9P280" "Intracellular trafficking proteins involved in CMT neuropathy" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "3" "1" "1.022" "0.996" "1.058" "0.980" "0.985" "0.983" "0.981" "0.957" "0.978" "799.7" "817.4" "796.2" "845.7" "783.6" "788.0" "786.3" "784.7" "765.1" "782.4" "" "" "" "" "" "" "" "" "" "" "749.3" "676.4" "739.2" "653.8" "667.9" "752.9" "718.5" "696.7" "765.1" "753.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7386528410140377558" "False" "High" "IsMasterProtein" "Q9H147" "Deoxynucleotidyltransferase terminal-interacting protein 1 OS=Homo sapiens OX=9606 GN=DNTTIP1 PE=1 SV=2" "0.000" "False" "12.347" "13" "5" "6" "5" "329" "37.0" "8.97" "14.62" "5" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf18192, Pf21229" "116092" "ENSG00000101457" "DNTTIP1" "B2RA18; hsa:116092; Q96DE3; Q9BQP2; Q9H147; Q9H148" "" "" "0" "0" "0.938" "0.953" "1.038" "0.955" "1.001" "1.012" "1.070" "0.997" "1.013" "469.2" "440.0" "447.0" "487.0" "448.3" "469.6" "474.9" "502.1" "468.0" "475.2" "" "" "" "" "" "" "" "" "" "" "439.6" "364.1" "415.0" "376.5" "382.1" "448.7" "434.0" "445.8" "468.0" "457.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1328397515797573102" "False" "High" "IsMasterProtein" "A6NDG6" "Glycerol-3-phosphate phosphatase OS=Homo sapiens OX=9606 GN=PGP PE=1 SV=1" "0.000" "False" "12.312" "15" "4" "5" "4" "321" "34.0" "6.14" "13.95" "4" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf13242, Pf13344" "283871" "ENSG00000184207" "PGP" "A6NDG6; hsa:283871" "" "Glycolysis" "1" "0" "0.984" "0.942" "1.028" "0.937" "0.919" "0.894" "0.929" "0.892" "0.934" "1033.1" "1016.9" "973.5" "1061.5" "967.8" "949.8" "923.8" "960.1" "922.0" "964.4" "" "" "" "" "" "" "" "" "" "" "968.0" "841.4" "903.7" "820.6" "824.9" "907.4" "844.1" "852.5" "922.0" "928.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4314325281228425264" "False" "High" "IsMasterProtein" "O15382" "Branched-chain-amino-acid aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=BCAT2 PE=1 SV=2" "0.000" "False" "12.308" "12" "4" "4" "4" "392" "44.3" "8.65" "14.42" "4" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf01063" "587" "ENSG00000105552" "BCAT2" "B2RB87; hsa:587; O00269; O15382; Q96KG1; Q9BTB6; Q9BUU6" "Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways" "Branched-chain amino acid catabolism" "3" "0" "1.121" "0.958" "1.249" "1.072" "1.015" "1.188" "1.026" "0.943" "1.028" "261.7" "293.3" "250.7" "327.0" "280.7" "265.6" "310.8" "268.4" "246.7" "269.2" "" "" "" "" "" "" "" "" "" "" "245.2" "242.7" "232.7" "252.8" "239.3" "253.8" "284.0" "238.3" "246.7" "259.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "947873724462567429" "False" "High" "IsMasterProtein" "Q9UNQ2" "Dimethyladenosine transferase OS=Homo sapiens OX=9606 GN=DIMT1 PE=1 SV=1" "0.000" "False" "12.301" "14" "5" "5" "5" "313" "35.2" "9.99" "14.16" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00398" "27292" "ENSG00000086189" "DIMT1" "O76025; Q9BU77; Q9UES1; Q9UNQ2" "" "rRNA modification in the nucleus and cytosol" "1" "0" "1.012" "0.960" "0.981" "0.949" "1.035" "1.072" "1.105" "1.049" "0.971" "396.1" "400.8" "380.1" "388.4" "376.0" "410.1" "424.6" "437.6" "415.3" "384.4" "" "" "" "" "" "" "" "" "" "" "371.1" "331.7" "352.9" "300.2" "320.5" "391.8" "388.0" "388.6" "415.3" "370.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7460825629413537855" "False" "High" "IsMasterProtein" "Q9BV40" "Vesicle-associated membrane protein 8 OS=Homo sapiens OX=9606 GN=VAMP8 PE=1 SV=1" "0.000" "False" "12.296" "39" "4" "6" "4" "100" "11.4" "7.34" "16.96" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957" "8673" "ENSG00000118640" "VAMP8" "hsa:8673; O60625; Q53SP9; Q6IB09; Q9BV40" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "Neutrophil degranulation; Cargo recognition for clathrin-mediated endocytosis; ER-Phagosome pathway; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis" "8" "0" "1.046" "0.914" "0.953" "0.977" "0.886" "0.839" "0.777" "0.845" "0.915" "959.7" "1003.5" "877.5" "914.1" "937.2" "850.1" "804.9" "746.0" "810.5" "877.9" "" "" "" "" "" "" "" "" "" "" "899.2" "830.4" "814.7" "706.7" "798.8" "812.1" "735.5" "662.4" "810.5" "845.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2774466273942528480" "False" "High" "IsMasterProtein" "O43379" "WD repeat-containing protein 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=4" "0.000" "False" "12.284" "3" "5" "5" "5" "1518" "165.8" "5.91" "13.05" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus" "" "Pf00400" "284403" "ENSG00000075702" "WDR62" "hsa:284403; O43379; Q63HP9; Q659D7; Q8NBF7; Q96AD9" "Primary ovarian insufficiency" "" "1" "0" "1.159" "0.975" "1.080" "1.048" "0.957" "1.116" "1.033" "1.023" "1.002" "176.4" "204.5" "171.9" "190.5" "184.8" "168.8" "196.9" "182.2" "180.4" "176.8" "" "" "" "" "" "" "" "" "" "" "165.2" "169.2" "159.6" "147.3" "157.6" "161.2" "179.9" "161.8" "180.4" "170.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-474422990152712875" "False" "High" "IsMasterProtein" "P61923" "Coatomer subunit zeta-1 OS=Homo sapiens OX=9606 GN=COPZ1 PE=1 SV=1" "0.000" "False" "12.266" "23" "3" "5" "3" "177" "20.2" "4.81" "12.22" "3" "transport" "other membranes;cytosol;ER/Golgi" "" "Pf01217" "22818" "ENSG00000111481" "COPZ1" "B4DDX8; B4DHZ0; F8VS17; F8VWL5; hsa:22818; P61923; Q549N6; Q9Y3C3" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "1.019" "1.037" "0.978" "1.091" "1.077" "0.947" "1.016" "1.055" "1.121" "149.5" "152.4" "155.0" "146.2" "163.1" "161.1" "141.6" "152.0" "157.8" "167.7" "" "" "" "" "" "" "" "" "" "" "140.1" "126.1" "143.9" "113.0" "139.1" "153.9" "129.4" "134.9" "157.8" "161.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5243510255652215024" "False" "High" "IsMasterProtein" "Q9Y448" "Small kinetochore-associated protein OS=Homo sapiens OX=9606 GN=KNSTRN PE=1 SV=2" "0.000" "False" "12.264" "15" "5" "5" "5" "316" "35.4" "6.30" "15.96" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "90417" "ENSG00000128944" "KNSTRN" "B4DXA7; hsa:90417; Q147U5; Q32Q57; Q5ISJ0; Q6P2S5; Q6PJM0; Q86XB4; Q9Y448" "Leukocyte-intrinsic Hippo pathway functions" "" "1" "0" "0.978" "0.881" "0.966" "0.947" "0.983" "0.874" "0.809" "0.890" "0.936" "825.7" "807.4" "727.5" "797.4" "781.9" "811.5" "721.8" "667.6" "734.7" "772.8" "" "" "" "" "" "" "" "" "" "" "773.7" "668.1" "675.4" "616.4" "666.4" "775.4" "659.5" "592.8" "734.7" "744.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8454366493935613494" "False" "High" "IsMasterProtein" "P19404" "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV2 PE=1 SV=2" "0.000" "False" "12.260" "16" "3" "5" "3" "249" "27.4" "8.06" "13.32" "3" "other metabolic processes;transport;developmental processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf01257" "4729" "ENSG00000178127" "NDUFV2" "hsa:4729; P19404; Q9BV41" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "1.341" "1.157" "1.333" "1.256" "1.080" "1.093" "1.135" "0.943" "1.107" "72.1" "96.7" "83.5" "96.2" "90.6" "77.9" "78.9" "81.9" "68.0" "79.9" "" "" "" "" "" "" "" "" "" "" "67.6" "80.0" "77.5" "74.3" "77.2" "74.4" "72.1" "72.7" "68.0" "76.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6259860464076082435" "False" "High" "IsMasterProtein" "Q9NR31" "Small COPII coat GTPase SAR1A OS=Homo sapiens OX=9606 GN=SAR1A PE=1 SV=1" "0.000" "False" "12.248" "18" "4" "6" "4" "198" "22.4" "6.68" "18.05" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00025" "56681" "ENSG00000079332" "SAR1A" "B4DQ19; hsa:56681; Q9NR31" "Sterol regulatory element-binding proteins (SREBP) signaling" "" "1" "0" "0.975" "0.984" "1.049" "1.034" "1.143" "1.053" "1.010" "1.033" "1.005" "1283.9" "1251.2" "1263.8" "1346.7" "1327.2" "1466.9" "1351.6" "1296.7" "1326.1" "1290.6" "" "" "" "" "" "" "" "" "" "" "1203.0" "1035.3" "1173.2" "1041.1" "1131.2" "1401.5" "1235.0" "1151.4" "1326.1" "1242.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5817906340983341960" "False" "High" "IsMasterProtein" "P61956" "Small ubiquitin-related modifier 2 OS=Homo sapiens OX=9606 GN=SUMO2 PE=1 SV=3" "0.000" "False" "12.246" "29" "3" "9" "1" "95" "10.9" "5.50" "26.48" "3" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11976" "6613" "ENSG00000188612" "SUMO2" "B2R4I2; hsa:6613; P55855; P61956; Q32Q42; Q6IPZ6; Q96HK1" "TAR syndrome" "SUMOylation of chromatin organization proteins; SUMOylation of intracellular receptors; SUMOylation of DNA damage response and repair proteins; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; Processing of DNA double-strand break ends; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5305151798806457032" "False" "High" "IsMasterProtein" "Q9UJ68" "Mitochondrial peptide methionine sulfoxide reductase OS=Homo sapiens OX=9606 GN=MSRA PE=1 SV=1" "0.000" "False" "12.237" "15" "4" "5" "4" "235" "26.1" "8.09" "11.48" "4" "protein metabolism;other metabolic processes;stress response" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01625" "4482" "ENSG00000175806; ENSG00000285250" "MSRA" "E9PAS8; hsa:4482; Q52TC4; Q549N4; Q66MI7; Q9UJ68" "Sulindac metabolic pathway; Methionine de novo and salvage pathway; 8p23.1 copy number variation syndrome" "Protein repair" "4" "0" "1.073" "1.048" "1.347" "0.921" "1.025" "1.062" "1.068" "1.031" "1.069" "79.9" "85.8" "83.7" "107.6" "73.6" "81.9" "84.8" "85.4" "82.4" "85.4" "" "" "" "" "" "" "" "" "" "" "74.9" "71.0" "77.7" "83.2" "62.8" "78.2" "77.5" "75.8" "82.4" "82.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7272269523816723745" "False" "High" "IsMasterProtein" "Q13613" "Myotubularin-related protein 1 OS=Homo sapiens OX=9606 GN=MTMR1 PE=1 SV=4" "0.000" "False" "12.234" "5" "4" "4" "4" "665" "74.6" "7.14" "13.35" "4" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf02893, Pf06602" "8776" "ENSG00000063601" "MTMR1" "A0A024RC07; hsa:8776; Q13613; Q9UBX6; Q9UEM0; Q9UQD5" "" "RHOF GTPase cycle; Synthesis of PIPs at the plasma membrane" "2" "0" "1.138" "0.993" "1.113" "1.017" "1.036" "0.991" "0.924" "1.033" "0.979" "511.7" "582.2" "508.1" "569.8" "520.2" "530.2" "507.2" "472.9" "528.5" "500.9" "" "" "" "" "" "" "" "" "" "" "479.5" "481.8" "471.7" "440.5" "443.4" "506.5" "463.4" "419.9" "528.5" "482.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1619272264168287387" "False" "High" "IsMasterProtein" "Q8WVT3" "Trafficking protein particle complex subunit 12 OS=Homo sapiens OX=9606 GN=TRAPPC12 PE=1 SV=3" "0.000" "False" "12.228" "6" "4" "4" "4" "735" "79.3" "4.91" "14.80" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf13174, Pf14559" "51112" "ENSG00000171853" "TRAPPC12" "B3KV01; D6W4Y2; hsa:51112; Q8WVT3; Q8WVW1; Q9Y395" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.146" "1.019" "1.107" "1.053" "1.002" "1.008" "1.004" "1.042" "1.029" "291.5" "334.0" "296.9" "322.8" "307.0" "292.0" "293.8" "292.7" "303.7" "300.0" "" "" "" "" "" "" "" "" "" "" "273.1" "276.4" "275.6" "249.5" "261.7" "279.0" "268.5" "259.9" "303.7" "288.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2309568012740462624" "False" "High" "IsMasterProtein" "Q02750" "Dual specificity mitogen-activated protein kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP2K1 PE=1 SV=2" "0.000" "False" "12.223" "7" "4" "5" "4" "393" "43.4" "6.62" "17.05" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "5604" "ENSG00000169032" "MAP2K1" "hsa:5604; Q02750" "IL-5 signaling pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; Endothelin pathways; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Aryl hydrocarbon receptor pathway; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; IL6 signaling pathway; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "Signaling by BRAF and RAF1 fusions; Uptake and function of anthrax toxins; Signal transduction by L1; RAF activation; MAP3K8 (TPL2)-dependent MAPK1/3 activation; MAPK3 (ERK1) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Negative feedback regulation of MAPK pathway; Signaling by MAP2K mutants" "102" "0" "0.974" "1.037" "1.055" "1.004" "1.034" "1.007" "1.004" "1.067" "0.996" "521.4" "507.7" "540.7" "550.3" "523.3" "539.1" "525.2" "523.5" "556.6" "519.4" "" "" "" "" "" "" "" "" "" "" "488.5" "420.1" "502.0" "425.4" "446.0" "515.1" "479.9" "464.8" "556.6" "500.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8413974576400389324" "False" "High" "IsMasterProtein" "Q9NQT5" "Exosome complex component RRP40 OS=Homo sapiens OX=9606 GN=EXOSC3 PE=1 SV=3" "0.000" "False" "12.222" "19" "4" "7" "4" "275" "29.6" "8.10" "23.83" "4" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf15985, Pf21261, Pf21262" "51010" "ENSG00000107371" "EXOSC3" "A8K0K6; hsa:51010; Q5QP85; Q9NQT5; Q9Y3A8" "" "ATF4 activates genes in response to endoplasmic reticulum stress; mRNA decay by 3' to 5' exoribonuclease; Major pathway of rRNA processing in the nucleolus and cytosol; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "6" "0" "0.980" "1.053" "1.014" "1.080" "1.111" "1.029" "1.123" "1.016" "1.083" "421.9" "413.6" "444.1" "427.9" "455.8" "468.9" "434.1" "473.8" "428.7" "457.1" "" "" "" "" "" "" "" "" "" "" "395.3" "342.3" "412.3" "330.8" "388.5" "448.0" "396.6" "420.6" "428.7" "440.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-705908850981217680" "False" "High" "IsMasterProtein" "Q9NWZ5" "Uridine-cytidine kinase-like 1 OS=Homo sapiens OX=9606 GN=UCKL1 PE=1 SV=2" "0.000" "False" "12.221" "9" "6" "8" "6" "548" "61.1" "7.36" "19.51" "6" "other metabolic processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00485, Pf14681" "54963" "ENSG00000198276" "UCKL1" "B7Z8N2; hsa:54963; Q5JWV0; Q70AQ5; Q8N524; Q9H3Z2; Q9NWZ5" "Pyrimidine metabolism" "Pyrimidine salvage" "2" "0" "1.103" "1.086" "1.156" "1.071" "1.092" "1.041" "0.929" "1.015" "1.078" "297.7" "328.5" "323.4" "344.2" "318.7" "325.1" "309.8" "276.6" "302.1" "321.0" "" "" "" "" "" "" "" "" "" "" "278.9" "271.8" "300.3" "266.1" "271.7" "310.6" "283.0" "245.6" "302.1" "309.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7446725702153589765" "False" "High" "IsMasterProtein" "Q9Y2T2" "AP-3 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP3M1 PE=1 SV=1" "0.000" "False" "12.220" "11" "4" "4" "4" "418" "46.9" "6.93" "14.36" "4" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00928, Pf01217" "26985" "ENSG00000185009" "AP3M1" "hsa:26985; Q5JQ12; Q9H5L2; Q9Y2T2" "" "Association of TriC/CCT with target proteins during biosynthesis" "1" "0" "0.954" "1.009" "0.971" "0.985" "0.982" "0.948" "0.951" "0.943" "1.000" "526.9" "502.4" "531.9" "511.3" "518.9" "517.4" "499.6" "501.0" "496.8" "527.0" "" "" "" "" "" "" "" "" "" "" "493.7" "415.7" "493.8" "395.3" "442.3" "494.4" "456.5" "444.8" "496.8" "507.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1282007746480283530" "False" "High" "IsMasterProtein" "Q9BRJ7" "Tudor-interacting repair regulator protein OS=Homo sapiens OX=9606 GN=NUDT16L1 PE=1 SV=1" "0.000" "False" "12.213" "22" "4" "5" "3" "211" "23.3" "8.91" "11.98" "4" "other biological processes" "nucleus" "nucleic acid binding activity" "" "84309" "ENSG00000168101" "NUDT16L1" "Q8NAI2; Q9BRJ7" "" "" "0" "1" "1.060" "1.000" "1.371" "1.131" "0.996" "1.220" "1.018" "1.004" "1.062" "268.7" "284.7" "268.8" "368.2" "303.9" "267.7" "327.8" "273.4" "269.8" "285.4" "" "" "" "" "" "" "" "" "" "" "251.7" "235.6" "249.5" "284.7" "259.0" "255.8" "299.5" "242.8" "269.8" "274.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4822956659812595428" "False" "High" "IsMasterProtein" "P17706" "Tyrosine-protein phosphatase non-receptor type 2 OS=Homo sapiens OX=9606 GN=PTPN2 PE=1 SV=2" "0.000" "False" "12.209" "13" "6" "9" "6" "415" "48.4" "8.29" "17.24" "6" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00102" "5771" "ENSG00000175354" "PTPN2" "A8K955; A8MXU3; hsa:5771; K7ENG3; P17706; Q96AU5; Q96HR2" "Immune response to tuberculosis; 5q35 copy number variation" "PKR-mediated signaling; Negative regulation of MET activity; Interleukin-37 signaling" "5" "0" "0.968" "0.992" "1.010" "0.998" "0.930" "0.988" "1.013" "0.967" "1.030" "609.4" "590.0" "604.3" "615.2" "608.3" "566.6" "601.9" "617.2" "589.0" "627.5" "" "" "" "" "" "" "" "" "" "" "571.0" "488.3" "561.0" "475.6" "518.5" "541.4" "550.0" "548.0" "589.0" "604.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4447255440292633936" "False" "High" "IsMasterProtein" "Q92625" "Ankyrin repeat and SAM domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ANKS1A PE=1 SV=4" "0.000" "False" "12.186" "6" "6" "6" "6" "1134" "123.0" "6.38" "13.67" "6" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding" "Pf00023, Pf00536, Pf00640" "23294" "ENSG00000064999" "ANKS1A" "A2RUC1; B4DQW8; hsa:23294; Q5JYI9; Q5SYR2; Q86WQ7; Q92625" "" "" "0" "0" "1.005" "0.963" "1.212" "1.099" "0.957" "1.138" "0.962" "0.958" "0.866" "77.6" "78.0" "74.8" "94.1" "85.3" "74.3" "88.3" "74.7" "74.4" "67.2" "" "" "" "" "" "" "" "" "" "" "72.7" "64.6" "69.4" "72.7" "72.7" "71.0" "80.7" "66.3" "74.4" "64.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1388353290409054284" "False" "High" "IsMasterProtein" "Q9NNW7" "Thioredoxin reductase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TXNRD2 PE=1 SV=3" "0.000" "False" "12.171" "10" "4" "6" "4" "524" "56.5" "7.50" "15.67" "4" "stress response;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf02852, Pf07992" "10587" "ENSG00000184470" "TXNRD2" "hsa:10587; O95840; Q96IJ2; Q9H2Z5; Q9NNW7; Q9NZV3; Q9NZV4; Q9P2Y0; Q9P2Y1; Q9UQU8" "Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Selenium metabolism and selenoproteins; Oxidative stress response; 22q11.2 copy number variation syndrome" "Detoxification of Reactive Oxygen Species" "7" "0" "1.051" "0.956" "1.000" "1.038" "1.033" "0.977" "0.994" "1.024" "1.044" "524.5" "551.2" "501.7" "524.4" "544.6" "541.8" "512.3" "521.5" "536.9" "547.4" "" "" "" "" "" "" "" "" "" "" "491.5" "456.1" "465.7" "405.4" "464.2" "517.7" "468.1" "463.1" "536.9" "527.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5043456387620106594" "False" "High" "IsMasterProtein" "Q86US8" "Telomerase-binding protein EST1A OS=Homo sapiens OX=9606 GN=SMG6 PE=1 SV=2" "0.000" "False" "12.170" "3" "4" "4" "4" "1419" "160.4" "7.05" "9.80" "4" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10373, Pf10374, Pf13638" "23293" "ENSG00000070366" "SMG6" "B7Z874; hsa:23293; O94837; Q86US8; Q86VH6; Q9UF60" "" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "1" "0" "1.056" "1.104" "1.555" "1.292" "1.242" "1.196" "0.974" "1.137" "1.154" "38.8" "41.0" "42.8" "60.3" "50.1" "48.2" "46.4" "37.8" "44.1" "44.8" "" "" "" "" "" "" "" "" "" "" "36.3" "33.9" "39.8" "46.6" "42.7" "46.0" "42.4" "33.5" "44.1" "43.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7794810011178551467" "False" "High" "IsMasterProtein" "O75348" "V-type proton ATPase subunit G 1 OS=Homo sapiens OX=9606 GN=ATP6V1G1 PE=1 SV=3" "0.000" "False" "12.170" "31" "4" "4" "4" "118" "13.7" "8.79" "12.84" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf03179" "9550" "ENSG00000136888" "ATP6V1G1" "hsa:9550; O75348; Q6IB33" "Osteoclast signaling; Proximal tubule transport" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "7" "0" "1.172" "1.147" "0.963" "1.083" "1.146" "1.059" "1.032" "1.091" "1.119" "372.1" "436.3" "426.7" "358.5" "403.2" "426.5" "393.9" "383.9" "406.2" "416.5" "" "" "" "" "" "" "" "" "" "" "348.7" "361.0" "396.1" "277.2" "343.6" "407.5" "359.9" "340.9" "406.2" "401.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5085231935458707065" "False" "High" "IsMasterProtein" "O75530" "Polycomb protein EED OS=Homo sapiens OX=9606 GN=EED PE=1 SV=2" "0.000" "False" "12.161" "10" "4" "5" "4" "441" "50.2" "7.03" "14.88" "4" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400" "8726" "ENSG00000074266" "EED" "A8K7V5; hsa:8726; O00149; O75530; Q6NTH2; Q7LDA5; Q7LDG8; Q86VV2; Q9UNY7" "Histone modifications; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma; 5q35 copy number variation" "Transcriptional Regulation by E2F6; HCMV Early Events; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis" "15" "0" "0.954" "1.116" "0.949" "1.022" "1.278" "1.013" "1.160" "1.279" "1.198" "287.0" "273.8" "320.3" "272.5" "293.3" "366.8" "290.8" "333.1" "367.1" "343.9" "" "" "" "" "" "" "" "" "" "" "268.9" "226.5" "297.4" "210.7" "250.0" "350.5" "265.7" "295.7" "367.1" "331.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3310116821494939621" "False" "High" "IsMasterProtein" "O00584" "Ribonuclease T2 OS=Homo sapiens OX=9606 GN=RNASET2 PE=1 SV=2" "0.000" "False" "12.157" "16" "4" "6" "4" "256" "29.5" "7.08" "16.79" "4" "RNA metabolism OR transcription;other metabolic processes;stress response" "non-structural extracellular;mitochondrion;ER/Golgi;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00445" "8635" "ENSG00000026297" "RNASET2" "B2RDA7; E1P5C3; hsa:8635; O00584; Q5T8Q0; Q8TCU2; Q9BZ46; Q9BZ47" "" "Neutrophil degranulation" "1" "0" "1.078" "1.028" "1.098" "1.149" "1.212" "0.991" "1.127" "1.140" "1.195" "98.8" "106.5" "101.6" "108.4" "113.5" "119.8" "97.9" "111.4" "112.6" "118.1" "" "" "" "" "" "" "" "" "" "" "92.6" "88.1" "94.3" "83.8" "96.8" "114.4" "89.5" "98.9" "112.6" "113.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2837359330570591993" "False" "High" "IsMasterProtein" "Q15022" "Polycomb protein SUZ12 OS=Homo sapiens OX=9606 GN=SUZ12 PE=1 SV=3" "0.000" "False" "12.126" "6" "4" "6" "4" "739" "83.0" "8.81" "20.82" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf09733" "23512" "ENSG00000178691" "SUZ12" "hsa:23512; Q15022; Q96BD9" "Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma; NF1 copy number variation syndrome" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; HCMV Early Events; SUMOylation of chromatin organization proteins; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis" "15" "0" "1.048" "1.015" "1.007" "1.023" "1.024" "0.992" "1.021" "1.025" "1.046" "795.3" "833.3" "807.3" "800.9" "813.2" "814.7" "788.8" "812.2" "815.5" "831.5" "" "" "" "" "" "" "" "" "" "" "745.2" "689.5" "749.5" "619.1" "693.2" "778.4" "720.8" "721.2" "815.5" "800.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6755213045612558311" "False" "High" "IsMasterProtein" "P53367" "Arfaptin-1 OS=Homo sapiens OX=9606 GN=ARFIP1 PE=1 SV=2" "0.000" "False" "12.122" "10" "4" "6" "3" "373" "41.7" "6.70" "17.11" "4" "transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf06456" "27236" "ENSG00000164144" "ARFIP1" "B4DS69; hsa:27236; P53367; Q2M2X4; Q3SYL4; Q9Y2X6" "" "" "0" "0" "0.996" "1.033" "1.024" "0.995" "1.028" "0.947" "0.970" "1.018" "1.030" "638.0" "635.4" "659.4" "653.5" "635.0" "656.0" "604.4" "618.8" "649.3" "657.4" "" "" "" "" "" "" "" "" "" "" "597.8" "525.8" "612.2" "505.2" "541.2" "626.8" "552.3" "549.4" "649.3" "633.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4146618986531713622" "False" "High" "IsMasterProtein" "P46782" "Small ribosomal subunit protein uS7 OS=Homo sapiens OX=9606 GN=RPS5 PE=1 SV=4" "0.000" "False" "12.106" "18" "4" "9" "4" "204" "22.9" "9.72" "22.12" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00177" "6193" "ENSG00000083845" "RPS5" "B2R4T2; hsa:6193; P46782; Q96BN0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.066" "1.175" "0.949" "1.117" "1.166" "1.232" "1.277" "1.319" "1.156" "1254.1" "1337.0" "1474.1" "1190.2" "1400.9" "1462.4" "1545.4" "1600.9" "1653.9" "1449.5" "" "" "" "" "" "" "" "" "" "" "1175.1" "1106.4" "1368.5" "920.1" "1194.1" "1397.2" "1412.0" "1421.5" "1653.9" "1395.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5439043522832827691" "False" "High" "IsMasterProtein" "Q8WZA0" "Protein LZIC OS=Homo sapiens OX=9606 GN=LZIC PE=1 SV=1" "0.000" "False" "12.105" "23" "4" "5" "4" "190" "21.5" "4.94" "16.72" "4" "other biological processes" "" "other molecular function" "Pf06384" "84328" "ENSG00000162441" "LZIC" "B2R6F0; B4E2N0; hsa:84328; Q8WZA0; Q96IU1" "" "" "0" "0" "1.065" "0.901" "0.955" "0.970" "1.058" "1.033" "1.104" "0.998" "0.971" "770.2" "820.2" "693.6" "735.9" "747.0" "815.1" "795.5" "850.5" "768.9" "747.5" "" "" "" "" "" "" "" "" "" "" "721.6" "678.7" "644.0" "568.9" "636.7" "778.7" "726.9" "755.2" "768.9" "719.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1008427851520544832" "False" "High" "IsMasterProtein" "Q4KMP7" "TBC1 domain family member 10B OS=Homo sapiens OX=9606 GN=TBC1D10B PE=1 SV=3" "0.000" "False" "12.103" "6" "4" "4" "4" "808" "87.1" "9.19" "12.25" "4" "transport;other biological processes" "plasma membrane;other membranes;cytosol" "enzyme regulator activity" "Pf00566" "26000" "ENSG00000169221" "TBC1D10B" "B9A6L0; hsa:26000; Q4KMP7; Q6IN54; Q6P530; Q71RG7; Q86VC5; Q9H8Z2; Q9NUN6; Q9UFP2" "" "TBC/RABGAPs" "1" "0" "0.953" "1.065" "1.173" "1.080" "1.043" "1.034" "1.093" "0.989" "1.045" "363.1" "346.2" "386.9" "425.9" "392.2" "378.8" "375.5" "396.8" "359.2" "379.6" "" "" "" "" "" "" "" "" "" "" "340.2" "286.5" "359.2" "329.2" "334.3" "361.9" "343.1" "352.3" "359.2" "365.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6123043622142940735" "False" "High" "IsMasterProtein" "P55145" "Mesencephalic astrocyte-derived neurotrophic factor OS=Homo sapiens OX=9606 GN=MANF PE=1 SV=3" "0.000" "False" "12.087" "18" "4" "5" "4" "182" "20.7" "8.69" "18.90" "4" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf10208, Pf20145" "7873" "ENSG00000145050" "MANF" "hsa:7873; P55145; Q14CX4; Q86U67; Q96IS4" "Orexin receptor pathway" "Platelet degranulation" "2" "0" "0.974" "0.931" "0.856" "1.044" "1.021" "0.922" "1.004" "0.889" "0.918" "275.2" "268.0" "256.2" "235.5" "287.3" "280.9" "253.7" "276.2" "244.6" "252.5" "" "" "" "" "" "" "" "" "" "" "257.8" "221.7" "237.9" "182.1" "244.9" "268.4" "231.8" "245.3" "244.6" "243.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8965718931841673636" "False" "High" "IsMasterProtein" "Q9Y496" "Kinesin-like protein KIF3A OS=Homo sapiens OX=9606 GN=KIF3A PE=1 SV=4" "0.000" "False" "12.085" "8" "5" "5" "4" "699" "80.0" "6.54" "11.22" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "11127" "ENSG00000131437" "KIF3A" "A8MSW9; hsa:11127; Q59EN1; Q86XE9; Q9Y496; Q9Y6V4" "Hedgehog signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Insulin signaling" "Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Kinesins; Hedgehog 'off' state; Activation of SMO" "11" "0" "0.948" "0.953" "0.968" "0.892" "0.963" "0.855" "0.935" "0.900" "1.040" "50.8" "48.2" "48.4" "49.1" "45.3" "48.9" "43.4" "47.5" "45.7" "52.8" "" "" "" "" "" "" "" "" "" "" "47.6" "39.8" "44.9" "38.0" "38.6" "46.7" "39.7" "42.1" "45.7" "50.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "289518910119416826" "False" "High" "IsMasterProtein" "P61966" "AP-1 complex subunit sigma-1A OS=Homo sapiens OX=9606 GN=AP1S1 PE=1 SV=1" "0.000" "False" "12.071" "31" "5" "5" "4" "158" "18.7" "5.73" "14.10" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "1174" "ENSG00000106367" "AP1S1" "B2R5D8; hsa:1174; P61966; P82267; Q00382; Q53YA7; Q9BTN4; Q9UDW9" "" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "4" "1" "1.041" "1.120" "1.063" "1.107" "1.038" "1.020" "1.054" "1.078" "1.048" "762.9" "794.6" "854.8" "810.9" "844.6" "791.6" "777.9" "804.4" "822.8" "799.2" "" "" "" "" "" "" "" "" "" "" "714.8" "657.5" "793.6" "626.9" "719.9" "756.3" "710.8" "714.2" "822.8" "769.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8569062232649936506" "False" "High" "IsMasterProtein" "Q9NVH2" "Integrator complex subunit 7 OS=Homo sapiens OX=9606 GN=INTS7 PE=1 SV=1" "0.000" "False" "12.062" "4" "5" "6" "5" "962" "106.8" "8.02" "18.33" "5" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "" "25896" "ENSG00000143493" "INTS7" "B4DLZ6; B7WNP6; B7WPB6; hsa:25896; Q8N4K7; Q8WUH5; Q9H9V3; Q9NVH2; Q9NVU5; Q9UFC6; Q9UFM3" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "1.027" "1.089" "0.970" "0.972" "0.942" "0.964" "0.974" "0.992" "1.011" "473.9" "486.9" "516.1" "459.6" "460.8" "446.3" "457.0" "461.6" "470.2" "479.1" "" "" "" "" "" "" "" "" "" "" "444.1" "402.9" "479.1" "355.3" "392.8" "426.4" "417.5" "409.8" "470.2" "461.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1099504193891774007" "False" "High" "IsMasterProtein" "Q13557" "Calcium/calmodulin-dependent protein kinase type II subunit delta OS=Homo sapiens OX=9606 GN=CAMK2D PE=1 SV=3" "0.000" "False" "12.060" "10" "5" "10" "3" "499" "56.3" "7.25" "13.53" "5" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08332" "817" "ENSG00000145349" "CAMK2D" "A8MVS8; hsa:817; Q13557; Q52PK4; Q59G21; Q8N553; Q9UGH6; Q9UQE9" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; SRF and miRs in smooth muscle differentiation and proliferation; Cardiac hypertrophic response; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Affected pathways in Duchenne muscular dystrophy; Calcium regulation in cardiac cells; ErbB signaling pathway" "Signaling by BRAF and RAF1 fusions; Assembly and cell surface presentation of NMDA receptors; Ion homeostasis; Ion transport by P-type ATPases; Interferon gamma signaling; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; Regulation of MECP2 expression and activity; Unblocking of NMDA receptors, glutamate binding and activation; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Phase 0 - rapid depolarisation; HSF1-dependent transactivation; CaMK IV-mediated phosphorylation of CREB" "33" "1" "1.065" "0.907" "1.216" "1.114" "1.022" "1.297" "1.048" "1.301" "1.085" "205.0" "218.4" "185.8" "249.2" "228.4" "209.4" "265.8" "214.8" "266.6" "222.3" "" "" "" "" "" "" "" "" "" "" "192.0" "180.7" "172.5" "192.7" "194.7" "200.1" "242.9" "190.7" "266.6" "214.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3327789120096563661" "False" "High" "IsMasterProtein" "Q9NR56" "Muscleblind-like protein 1 OS=Homo sapiens OX=9606 GN=MBNL1 PE=1 SV=2" "0.000" "False" "12.058" "9" "4" "6" "3" "388" "41.8" "8.90" "18.24" "4" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608" "4154" "ENSG00000152601" "MBNL1" "E9PBW7; hsa:4154; O43311; O43797; Q86UV8; Q86UV9; Q96P92; Q96RE3; Q9NR56" "Adipogenesis" "" "1" "1" "0.993" "1.000" "0.951" "0.983" "1.007" "0.929" "0.945" "0.926" "0.966" "638.0" "633.3" "638.1" "606.8" "627.2" "642.6" "592.5" "603.2" "590.8" "616.6" "" "" "" "" "" "" "" "" "" "" "597.8" "524.1" "592.4" "469.1" "534.6" "614.0" "541.4" "535.6" "590.8" "593.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5887664116474982474" "False" "High" "IsMasterProtein" "Q9H6E4" "Coiled-coil domain-containing protein 134 OS=Homo sapiens OX=9606 GN=CCDC134 PE=1 SV=1" "0.000" "False" "12.048" "20" "4" "5" "4" "229" "26.5" "8.85" "8.49" "4" "developmental processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf15002" "79879" "ENSG00000100147" "CCDC134" "hsa:79879; Q9H6E4" "" "" "0" "0" "1.014" "0.905" "1.309" "1.132" "0.974" "1.118" "1.096" "0.920" "1.030" "73.5" "74.5" "66.5" "96.2" "83.2" "71.6" "82.1" "80.6" "67.6" "75.7" "" "" "" "" "" "" "" "" "" "" "68.9" "61.7" "61.7" "74.4" "70.9" "68.4" "75.1" "71.5" "67.6" "72.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6226740505465900925" "False" "High" "IsMasterProtein" "Q08170" "Serine/arginine-rich splicing factor 4 OS=Homo sapiens OX=9606 GN=SRSF4 PE=1 SV=2" "0.000" "False" "12.041" "9" "5" "7" "1" "494" "56.6" "11.52" "19.97" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076" "6429" "ENSG00000116350" "SRSF4" "hsa:6429; Q08170; Q5VXP1; Q9BUA4; Q9UEB5" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "6" "0" "1.061" "1.166" "1.025" "1.046" "1.143" "1.133" "1.098" "1.197" "1.172" "148.9" "158.0" "173.6" "152.6" "155.8" "170.2" "168.7" "163.5" "178.2" "174.5" "" "" "" "" "" "" "" "" "" "" "139.5" "130.8" "161.2" "118.0" "132.8" "162.6" "154.2" "145.2" "178.2" "168.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4118942694403519746" "False" "High" "IsMasterProtein" "Q13492" "Phosphatidylinositol-binding clathrin assembly protein OS=Homo sapiens OX=9606 GN=PICALM PE=1 SV=2" "0.000" "False" "12.039" "7" "5" "5" "5" "652" "70.7" "7.90" "12.37" "5" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf07651" "8301" "ENSG00000073921" "PICALM" "B4DTM3; E9PN05; F8VPG7; hsa:8301; O60700; Q13492; Q4LE54; Q6GMQ6; Q86XZ9" "" "Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; RND3 GTPase cycle" "4" "0" "0.991" "0.937" "0.936" "0.970" "0.936" "0.975" "0.926" "0.957" "0.941" "532.0" "527.3" "498.2" "498.1" "516.3" "498.0" "518.8" "492.6" "508.9" "500.5" "" "" "" "" "" "" "" "" "" "" "498.5" "436.4" "462.5" "385.1" "440.1" "475.8" "474.1" "437.4" "508.9" "481.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2427980612750648457" "False" "High" "IsMasterProtein" "P21359" "Neurofibromin OS=Homo sapiens OX=9606 GN=NF1 PE=1 SV=2" "0.000" "False" "12.032" "2" "6" "7" "6" "2839" "319.2" "7.39" "13.11" "6" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00616, Pf13716" "4763" "ENSG00000196712" "NF1" "hsa:4763; O00662; P21359; Q14284; Q14930; Q14931; Q9UMK3" "Pilocytic astrocytoma; Glioblastoma signaling pathways; Aryl hydrocarbon receptor pathway; MECP2 and associated Rett syndrome; MAPK signaling pathway; Ras signaling; Transcription co-factors SKI and SKIL protein partners; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Melanoma; EGFR tyrosine kinase inhibitor resistance; NF1 copy number variation syndrome" "Regulation of RAS by GAPs; RAS signaling downstream of NF1 loss-of-function variants" "14" "0" "1.002" "0.992" "1.145" "1.051" "1.009" "0.998" "1.054" "1.056" "1.023" "235.2" "235.6" "233.3" "269.4" "247.1" "237.3" "234.8" "247.9" "248.3" "240.7" "" "" "" "" "" "" "" "" "" "" "220.4" "195.0" "216.6" "208.3" "210.6" "226.7" "214.6" "220.1" "248.3" "231.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1508959840554036408" "False" "High" "IsMasterProtein" "Q969V6" "Myocardin-related transcription factor A OS=Homo sapiens OX=9606 GN=MRTFA PE=1 SV=1" "0.000" "False" "12.027" "4" "4" "4" "3" "931" "98.9" "5.86" "11.03" "4" "cell organization and biogenesis;stress response;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02037, Pf02755" "57591" "ENSG00000196588" "MRTFA" "hsa:57591; Q8TCL1; Q969V6; Q96SC5; Q96SC6; Q9P2B0" "" "RHO GTPases Activate Formins; SUMOylation of transcription cofactors" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2555536461123867922" "False" "High" "IsMasterProtein" "Q86U90" "Threonylcarbamoyl-AMP synthase OS=Homo sapiens OX=9606 GN=YRDC PE=1 SV=1" "0.000" "False" "12.022" "19" "4" "5" "4" "279" "29.3" "8.57" "11.10" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01300" "79693" "ENSG00000196449" "YRDC" "hsa:79693; Q4W4X8; Q6NVW3; Q7L4E4; Q7Z2I4; Q86U90; Q9H5F8" "" "" "0" "0" "1.078" "1.127" "1.185" "1.115" "1.056" "1.172" "1.102" "1.070" "1.153" "197.6" "213.0" "222.7" "234.1" "220.2" "208.6" "231.6" "217.6" "211.4" "227.8" "" "" "" "" "" "" "" "" "" "" "185.1" "176.3" "206.8" "181.0" "187.7" "199.3" "211.6" "193.2" "211.4" "219.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8914003618785624230" "False" "High" "IsMasterProtein" "O75934" "Pre-mRNA-splicing factor SPF27 OS=Homo sapiens OX=9606 GN=BCAS2 PE=1 SV=1" "0.000" "False" "12.019" "13" "4" "6" "4" "225" "26.1" "5.66" "15.72" "4" "RNA metabolism OR transcription;other metabolic processes" "cytoskeleton;nucleus;other cell component" "" "Pf05700" "10286" "ENSG00000116752" "BCAS2" "hsa:10286; O75934; Q6FGS0" "" "mRNA Splicing - Major Pathway" "1" "0" "0.942" "0.972" "0.999" "1.035" "1.027" "1.181" "1.308" "1.066" "1.042" "411.7" "387.7" "400.1" "411.5" "426.3" "422.6" "486.3" "538.6" "439.0" "429.2" "" "" "" "" "" "" "" "" "" "" "385.8" "320.8" "371.5" "318.1" "363.4" "403.8" "444.4" "478.2" "439.0" "413.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4892501601992705752" "False" "High" "IsMasterProtein" "Q5K651" "Sterile alpha motif domain-containing protein 9 OS=Homo sapiens OX=9606 GN=SAMD9 PE=1 SV=1" "0.000" "False" "12.016" "2" "5" "5" "5" "1589" "184.2" "7.83" "13.98" "5" "cell organization and biogenesis;stress response;transport" "cytosol;other cell component" "" "Pf00536" "54809" "ENSG00000205413" "SAMD9" "A2RU68; hsa:54809; Q5K649; Q5K651; Q6P080; Q75N21; Q8IVG6; Q9NXS8" "" "" "0" "0" "0.992" "0.989" "1.089" "1.049" "0.981" "1.059" "0.992" "0.982" "1.043" "900.3" "892.9" "890.7" "980.1" "944.9" "883.4" "953.8" "893.3" "884.3" "938.8" "" "" "" "" "" "" "" "" "" "" "843.6" "738.9" "826.9" "757.6" "805.4" "844.0" "871.5" "793.1" "884.3" "903.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1552810518553592315" "False" "High" "IsMasterProtein" "P49662" "Caspase-4 OS=Homo sapiens OX=9606 GN=CASP4 PE=1 SV=1" "0.000" "False" "12.013" "14" "5" "5" "5" "377" "43.2" "6.00" "13.28" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00619, Pf00656" "837" "ENSG00000196954" "CASP4" "A2NHL8; A2NHL9; A2NHM0; B3KPZ9; B4DJH5; B4E2D2; hsa:837; O95601; P49662; Q7KYX7; Q9UG96" "Apoptosis modulation and signaling; Apoptosis" "NOD1/2 Signaling Pathway; Pyroptosis" "4" "0" "1.081" "0.943" "1.075" "1.008" "1.067" "0.999" "1.017" "0.943" "0.982" "372.9" "403.2" "351.6" "400.9" "376.0" "397.7" "372.7" "379.1" "351.6" "366.3" "" "" "" "" "" "" "" "" "" "" "349.4" "333.6" "326.4" "309.9" "320.5" "380.0" "340.5" "336.6" "351.6" "352.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7526425454586707099" "False" "High" "IsMasterProtein" "Q8TE02" "Elongator complex protein 5 OS=Homo sapiens OX=9606 GN=ELP5 PE=1 SV=3" "0.000" "False" "12.011" "15" "4" "4" "4" "300" "33.2" "4.98" "13.00" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10483" "23587" "ENSG00000170291; ENSG00000288485" "ELP5" "A8K1M5; D3DTN9; Q659B6; Q7Z2T4; Q8TDR9; Q8TE02; Q9BUB2; Q9Y2Q4" "" "HATs acetylate histones" "1" "0" "0.981" "0.913" "1.021" "1.006" "1.076" "1.128" "1.094" "1.053" "0.993" "198.8" "195.1" "181.5" "203.1" "200.1" "214.0" "224.3" "217.5" "209.3" "197.3" "" "" "" "" "" "" "" "" "" "" "186.3" "161.4" "168.5" "157.0" "170.5" "204.4" "204.9" "193.1" "209.3" "190.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8120903851432865653" "False" "High" "IsMasterProtein" "P01889" "HLA class I histocompatibility antigen, B alpha chain OS=Homo sapiens OX=9606 GN=HLA-B PE=1 SV=3" "0.000" "False" "11.995" "11" "4" "4" "2" "362" "40.4" "5.85" "12.48" "4" "stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00129, Pf06623, Pf07654" "3106" "ENSG00000234745" "HLA-B" "A0A2I6Q7B5; B0V0B8; G3GN01; hsa:3106; O02862; O02956; O02957; O02960; O19555; O19556; O19595; O19615; O19624; O19625; O19627; O19641; O19651; O19675; O19692; O19758; O19779; O19783; O46702; O62897; O62901; O62915; O62917; O62919; O77933; O77959; O78053; O78138; O78160; O78163; O78172; O78173; O78180; O78217; O95730; O98140; P01889; P01890; P03989; P10317; P10318; P10319; P10320; P18463; P18464; P18465; P19373; P30460; P30461; P30462; P30463; P30464; P30465; P30466; P30467; P30468; P30469; P30470; P30471; P30472; P30473; P30474; P30475; P30476; P30477; P30478; P30479; P30480; P30481; P30482; P30483; P30484; P30485; P30486; P30487; P30488; P30489; P30490; P30491; P30492; P30493; P30494; P30495; P30496; P30497; P30498; P30513; P30685; P79489; P79490; P79496; P79504; P79523; P79524; P79542; P79555; Q04826; Q08136; Q29633; Q29636; Q29638; Q29661; Q29665; Q29678; Q29679; Q29681; Q29693; Q29695; Q29697; Q29718; Q29742; Q29749; Q29762; Q29764; Q29829; Q29836; Q29842; Q29845; Q29846; Q29847; Q29848; Q29850; Q29851; Q29852; Q29854; Q29855; Q29857; Q29858; Q29861; Q29924; Q29925; Q29933; Q29935; Q29936; Q29940; Q29953; Q29961; Q29982; Q30173; Q30198; Q31603; Q31610; Q31612; Q31613; Q546L8; Q546M4; Q5JP37; Q5QT24; Q5RIP1; Q5SRJ2; Q5TK76; Q5TK77; Q860I4; Q861B5; Q8HWF0; Q8MGQ3; Q8MHN4; Q8SNC5; Q95343; Q95344; Q95365; Q95369; Q95392; Q95HA3; Q95HA8; Q95HM9; Q95IA6; Q95IB8; Q95IH5; Q95J00; Q96IT9; Q9BCM6; Q9BCM7; Q9BCM8; Q9BD06; Q9BD38; Q9BD43; Q9GIL3; Q9GIM3; Q9GIX1; Q9GIY5; Q9GIZ0; Q9GIZ9; Q9GJ00; Q9GJ17; Q9GJ20; Q9GJ23; Q9GJ31; Q9GJF0; Q9GJM7; Q9MX21; Q9MY37; Q9MY42; Q9MY43; Q9MY61; Q9MY75; Q9MY78; Q9MY79; Q9MY84; Q9MY92; Q9MY93; Q9MY94; Q9MYB8; Q9MYC3; Q9MYC7; Q9MYF4; Q9MYG1; Q9TP35; Q9TP36; Q9TP37; Q9TP95; Q9TPQ7; Q9TPQ9; Q9TPR2; Q9TPR4; Q9TPS6; Q9TPT2; Q9TPT4; Q9TPT6; Q9TPV2; Q9TQG1; Q9TQH3; Q9TQH6; Q9TQH7; Q9TQH8; Q9TQH9; Q9TQM2; Q9TQN4; Q9TQN6; Q9UQS8; Q9UQT0" "Proteasome degradation; Allograft rejection; Ebola virus infection in host; TAR syndrome; Type II interferon signaling" "Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ER-Phagosome pathway; DAP12 interactions; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon gamma signaling; Interferon alpha/beta signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway" "14" "0" "1.079" "1.016" "1.037" "0.950" "0.907" "0.888" "0.967" "0.905" "0.921" "502.1" "541.8" "510.1" "520.8" "477.1" "455.4" "445.6" "485.4" "454.3" "462.4" "" "" "" "" "" "" "" "" "" "" "470.4" "448.3" "473.5" "402.6" "406.7" "435.1" "407.2" "431.0" "454.3" "445.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2137073451658822686" "False" "High" "IsMasterProtein" "Q01664" "Transcription factor AP-4 OS=Homo sapiens OX=9606 GN=TFAP4 PE=1 SV=2" "0.000" "False" "11.980" "11" "4" "5" "4" "338" "38.7" "5.87" "16.58" "4" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "7023" "ENSG00000090447" "TFAP4" "hsa:7023; O60409; Q01664" "DYRK1A involvement regarding cell proliferation in brain development" "" "1" "0" "0.965" "0.970" "0.979" "1.022" "1.033" "0.896" "0.924" "0.886" "0.941" "680.8" "656.9" "660.4" "666.2" "696.0" "703.2" "610.0" "629.1" "603.3" "640.5" "" "" "" "" "" "" "" "" "" "" "637.9" "543.6" "613.1" "515.0" "593.3" "671.8" "557.4" "558.6" "603.3" "616.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3246938043361698856" "False" "High" "IsMasterProtein" "O94842" "TOX high mobility group box family member 4 OS=Homo sapiens OX=9606 GN=TOX4 PE=1 SV=1" "0.000" "False" "11.957" "7" "4" "5" "4" "621" "66.2" "5.06" "14.04" "4" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00505" "9878" "ENSG00000092203" "TOX4" "B4DPY8; B4DSM0; E7EV69; hsa:9878; O94842" "" "" "0" "0" "1.053" "1.050" "1.066" "1.062" "1.066" "1.075" "1.097" "1.120" "1.073" "757.1" "797.2" "794.8" "806.8" "804.2" "807.1" "814.1" "830.6" "847.8" "812.1" "" "" "" "" "" "" "" "" "" "" "709.4" "659.7" "737.9" "623.7" "685.5" "771.1" "743.9" "737.5" "847.8" "782.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1054037842820128470" "False" "High" "IsMasterProtein" "Q9BXK1" "Krueppel-like factor 16 OS=Homo sapiens OX=9606 GN=KLF16 PE=1 SV=1" "0.000" "False" "11.956" "21" "3" "3" "3" "252" "25.4" "9.88" "15.73" "3" "signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "83855" "ENSG00000129911" "KLF16" "hsa:83855; Q9BXK1" "" "" "0" "0" "1.105" "1.052" "1.013" "1.027" "1.107" "1.036" "1.056" "1.038" "1.033" "465.2" "514.2" "489.6" "471.4" "477.9" "514.8" "481.7" "491.2" "482.7" "480.6" "" "" "" "" "" "" "" "" "" "" "435.9" "425.5" "454.5" "364.4" "407.4" "491.9" "440.2" "436.1" "482.7" "462.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2679816748943853066" "False" "High" "IsMasterProtein" "Q9ULH7" "Myocardin-related transcription factor B OS=Homo sapiens OX=9606 GN=MRTFB PE=1 SV=3" "0.000" "False" "11.954" "3" "4" "5" "3" "1088" "118.1" "6.28" "16.69" "4" "other biological processes" "nucleus" "other molecular function" "Pf02037, Pf02755" "57496" "ENSG00000186260" "MRTFB" "A6ND53; B4DGT8; hsa:57496; Q68CT1; Q6UB16; Q86WW2; Q8N226; Q9ULH7" "" "" "0" "1" "1.008" "0.961" "0.979" "0.973" "0.955" "0.980" "0.952" "0.945" "0.955" "1492.8" "1504.5" "1434.4" "1461.0" "1452.3" "1425.0" "1462.9" "1421.0" "1411.3" "1426.3" "" "" "" "" "" "" "" "" "" "" "1398.7" "1244.9" "1331.7" "1129.4" "1237.9" "1361.4" "1336.7" "1261.7" "1411.3" "1373.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6660438545085976361" "False" "High" "IsMasterProtein" "Q9BUL5" "PHD finger protein 23 OS=Homo sapiens OX=9606 GN=PHF23 PE=1 SV=1" "0.000" "False" "11.951" "11" "4" "4" "4" "403" "43.8" "5.78" "15.09" "4" "other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13831" "79142" "ENSG00000040633" "PHF23" "A1DZ74; B3KVH8; B4DLK6; D3DTN4; hsa:79142; Q8IZK0; Q96HG7; Q9BUL5; Q9H5X0" "" "" "0" "0" "1.104" "1.041" "1.137" "1.137" "1.075" "1.113" "1.082" "1.061" "1.141" "339.5" "374.6" "353.5" "386.0" "386.1" "365.1" "377.7" "367.3" "360.3" "387.4" "" "" "" "" "" "" "" "" "" "" "318.1" "310.0" "328.2" "298.4" "329.1" "348.8" "345.1" "326.2" "360.3" "373.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5255338936326354588" "False" "High" "IsMasterProtein" "O75448" "Mediator of RNA polymerase II transcription subunit 24 OS=Homo sapiens OX=9606 GN=MED24 PE=1 SV=1" "0.000" "False" "11.948" "4" "4" "5" "4" "989" "110.2" "6.95" "9.83" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11277" "9862" "ENSG00000008838" "MED24" "A8K4S5; B3KMR9; hsa:9862; O75448; Q14143; Q9NNY5" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "0.969" "1.016" "1.005" "1.050" "0.995" "0.968" "0.977" "0.997" "1.002" "1044.3" "1012.4" "1060.8" "1050.0" "1096.3" "1039.6" "1011.0" "1020.1" "1041.2" "1046.5" "" "" "" "" "" "" "" "" "" "" "978.5" "837.7" "984.9" "811.7" "934.5" "993.2" "923.8" "905.7" "1041.2" "1007.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3724111757375065163" "False" "High" "IsMasterProtein" "Q9P0W2" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related OS=Homo sapiens OX=9606 GN=HMG20B PE=1 SV=1" "0.000" "False" "11.942" "12" "4" "5" "4" "317" "35.8" "9.35" "13.77" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00505" "10362" "ENSG00000064961" "HMG20B" "A6NMS5; D6W616; hsa:10362; Q6IBP8; Q8NBD5; Q9HD21; Q9P0W2; Q9Y491; Q9Y4A2" "" "Factors involved in megakaryocyte development and platelet production; Potential therapeutics for SARS; HDACs deacetylate histones" "3" "0" "0.925" "0.901" "1.050" "1.002" "0.994" "0.946" "0.901" "0.901" "0.926" "694.8" "642.6" "626.0" "729.2" "696.2" "690.9" "657.6" "626.2" "625.9" "643.6" "" "" "" "" "" "" "" "" "" "" "651.0" "531.8" "581.1" "563.7" "593.5" "660.1" "600.8" "556.0" "625.9" "619.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6183242122487478565" "False" "High" "IsMasterProtein" "Q8TDP1" "Ribonuclease H2 subunit C OS=Homo sapiens OX=9606 GN=RNASEH2C PE=1 SV=1" "0.000" "False" "11.938" "34" "4" "5" "4" "164" "17.8" "5.03" "14.86" "4" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "" "Pf08615" "84153" "ENSG00000172922" "RNASEH2C" "hsa:84153; Q8TDP1; Q9H7F5" "" "" "0" "0" "0.993" "1.027" "1.122" "1.073" "0.953" "1.176" "1.055" "1.061" "1.067" "429.5" "426.5" "441.3" "481.8" "460.6" "409.1" "505.0" "453.0" "455.7" "458.3" "" "" "" "" "" "" "" "" "" "" "402.4" "352.9" "409.7" "372.4" "392.6" "390.9" "461.5" "402.3" "455.7" "441.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-765021547925747573" "False" "High" "IsMasterProtein" "P49366" "Deoxyhypusine synthase OS=Homo sapiens OX=9606 GN=DHPS PE=1 SV=1" "0.000" "False" "11.930" "12" "4" "4" "4" "369" "40.9" "5.36" "12.29" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01916" "1725" "ENSG00000095059" "DHPS" "A8K688; hsa:1725; M0R1I5; P49366; Q13184; Q13276; Q9UDG0" "" "Hypusine synthesis from eIF5A-lysine" "1" "0" "1.165" "1.191" "1.551" "1.121" "1.068" "1.123" "1.068" "0.970" "0.913" "19.4" "22.6" "23.1" "30.1" "21.7" "20.7" "21.8" "20.7" "18.8" "17.7" "" "" "" "" "" "" "" "" "" "" "18.2" "18.7" "21.4" "23.2" "18.5" "19.8" "19.9" "18.4" "18.8" "17.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1541335516874274105" "False" "High" "IsMasterProtein" "Q14527" "Helicase-like transcription factor OS=Homo sapiens OX=9606 GN=HLTF PE=1 SV=2" "0.000" "False" "11.926" "4" "4" "4" "4" "1009" "113.9" "8.60" "11.50" "4" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf08797, Pf13923" "6596" "ENSG00000071794" "HLTF" "D3DNH3; Q14527; Q14536; Q16051; Q7KYJ6; Q86YA5; Q92652; Q96KM9" "Retinoblastoma gene in cancer" "E3 ubiquitin ligases ubiquitinate target proteins" "2" "0" "0.977" "0.884" "1.150" "1.038" "0.947" "0.968" "0.927" "0.974" "0.945" "169.7" "165.8" "150.0" "195.1" "176.2" "160.7" "164.3" "157.3" "165.3" "160.5" "" "" "" "" "" "" "" "" "" "" "159.0" "137.2" "139.3" "150.8" "150.2" "153.5" "150.1" "139.7" "165.3" "154.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "141064915599705120" "False" "High" "IsMasterProtein" "Q9P000" "COMM domain-containing protein 9 OS=Homo sapiens OX=9606 GN=COMMD9 PE=1 SV=2" "0.000" "False" "11.921" "18" "4" "4" "4" "198" "21.8" "5.88" "12.70" "4" "transport;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf07258, Pf20923" "29099" "ENSG00000110442" "COMMD9" "E9PAN2; hsa:29099; Q96FI2; Q9H0R0; Q9P000" "" "Neutrophil degranulation; Neddylation" "2" "0" "1.148" "1.049" "1.113" "1.018" "1.168" "1.033" "0.998" "1.044" "1.008" "261.0" "299.6" "273.7" "290.5" "265.8" "304.7" "269.6" "260.4" "272.4" "263.2" "" "" "" "" "" "" "" "" "" "" "244.5" "247.9" "254.1" "224.6" "226.5" "291.1" "246.4" "231.2" "272.4" "253.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8461791288305677895" "False" "High" "IsMasterProtein" "Q92783" "Signal transducing adapter molecule 1 OS=Homo sapiens OX=9606 GN=STAM PE=1 SV=3" "0.000" "False" "11.920" "8" "4" "4" "4" "540" "59.1" "4.82" "14.85" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00790, Pf02809" "8027" "ENSG00000136738" "STAM" "B0YJ99; D3DRU5; hsa:8027; Q8N6D9; Q92783" "Vitamin D receptor pathway; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway" "RHOU GTPase cycle; Endosomal Sorting Complex Required For Transport (ESCRT); Metalloprotease DUBs; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "11" "0" "0.800" "1.034" "0.961" "1.036" "1.047" "1.131" "1.061" "1.087" "0.978" "125.4" "100.3" "129.7" "120.6" "130.0" "131.3" "141.9" "133.1" "136.4" "122.7" "" "" "" "" "" "" "" "" "" "" "117.5" "83.0" "120.4" "93.2" "110.8" "125.5" "129.6" "118.2" "136.4" "118.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6197247688658885913" "False" "High" "IsMasterProtein" "Q8N1B4" "Vacuolar protein sorting-associated protein 52 homolog OS=Homo sapiens OX=9606 GN=VPS52 PE=1 SV=1" "0.000" "False" "11.915" "7" "5" "6" "5" "723" "82.2" "5.99" "15.37" "5" "transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04129, Pf20655" "6293" "ENSG00000206286; ENSG00000223501; ENSG00000224455; ENSG00000225590; ENSG00000228425; ENSG00000236014" "VPS52" "A2BF38; B0UZZ4; B4DNI9; hsa:6293; Q53GR4; Q5JPA0; Q5SQW1; Q8IUN6; Q8N1B4; Q9NPT5" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "0.986" "0.989" "1.040" "1.059" "1.032" "0.987" "0.977" "0.965" "1.042" "507.2" "500.0" "501.7" "527.3" "537.4" "523.6" "500.6" "495.7" "489.6" "528.5" "" "" "" "" "" "" "" "" "" "" "475.3" "413.8" "465.7" "407.6" "458.0" "500.3" "457.4" "440.1" "489.6" "508.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2509931178025596273" "False" "High" "IsMasterProtein" "Q5JSP0" "FYVE, RhoGEF and PH domain-containing protein 3 OS=Homo sapiens OX=9606 GN=FGD3 PE=1 SV=1" "0.000" "False" "11.905" "6" "5" "5" "5" "725" "79.4" "6.15" "13.00" "5" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621, Pf01363" "89846" "ENSG00000127084" "FGD3" "F8W7P2; hsa:89846; Q4VX84; Q5JSP0; Q7Z7D9; Q8N5G1" "" "CDC42 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "3" "0" "0.727" "1.122" "0.762" "0.816" "0.671" "0.593" "0.663" "0.628" "0.660" "523.0" "380.4" "587.1" "398.7" "427.0" "350.9" "310.1" "346.6" "328.5" "345.1" "" "" "" "" "" "" "" "" "" "" "490.1" "314.8" "545.0" "308.2" "364.0" "335.2" "283.4" "307.7" "328.5" "332.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "621637110793391590" "False" "High" "IsMasterProtein" "Q9BV79" "Enoyl-[acyl-carrier-protein] reductase, mitochondrial OS=Homo sapiens OX=9606 GN=MECR PE=1 SV=2" "0.000" "False" "11.904" "11" "4" "5" "4" "373" "40.4" "8.76" "12.38" "4" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00107, Pf08240" "51102" "ENSG00000116353" "MECR" "B3KT72; Q5SYU0; Q5SYU1; Q5SYU2; Q6IBU9; Q9BV79; Q9Y373" "Fatty acid biosynthesis; Mitochondrial fatty acid synthesis pathway" "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA" "3" "0" "0.909" "1.001" "0.878" "0.925" "0.898" "0.778" "0.967" "0.924" "0.940" "133.7" "121.5" "133.8" "117.4" "123.7" "120.0" "104.1" "129.3" "123.5" "125.7" "" "" "" "" "" "" "" "" "" "" "125.3" "100.6" "124.3" "90.7" "105.4" "114.7" "95.1" "114.8" "123.5" "121.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3819373703684901703" "False" "High" "IsMasterProtein" "Q2KHT3" "Protein CLEC16A OS=Homo sapiens OX=9606 GN=CLEC16A PE=1 SV=2" "0.000" "False" "11.901" "4" "4" "4" "4" "1053" "117.6" "5.86" "12.82" "4" "other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf09758, Pf19439" "23274" "ENSG00000038532" "CLEC16A" "hsa:23274; O15058; Q2KHT3; Q6ZTB2" "Vitamin D receptor pathway" "" "1" "0" "1.029" "0.957" "1.080" "1.008" "1.065" "1.097" "0.979" "1.061" "1.147" "178.8" "184.0" "171.2" "193.1" "180.2" "190.4" "196.2" "175.1" "189.8" "205.1" "" "" "" "" "" "" "" "" "" "" "167.5" "152.3" "158.9" "149.3" "153.6" "181.9" "179.3" "155.4" "189.8" "197.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1699378345202944964" "False" "High" "IsMasterProtein" "Q96MX6" "Dynein axonemal assembly factor 10 OS=Homo sapiens OX=9606 GN=DNAAF10 PE=1 SV=1" "0.000" "False" "11.901" "11" "4" "4" "4" "357" "39.7" "8.09" "14.53" "4" "cell organization and biogenesis;other biological processes" "other cell component" "other molecular function" "Pf00400" "116143" "ENSG00000243667" "DNAAF10" "hsa:116143; Q96CR6; Q96MX6" "" "" "0" "0" "0.916" "0.952" "0.908" "0.955" "0.923" "0.932" "0.894" "0.953" "0.934" "833.5" "763.8" "793.5" "756.6" "796.0" "769.1" "777.0" "745.3" "794.7" "778.9" "" "" "" "" "" "" "" "" "" "" "781.0" "632.0" "736.7" "584.9" "678.5" "734.8" "710.0" "661.7" "794.7" "750.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8855314221236891810" "False" "High" "IsMasterProtein" "Q5T0F9" "Coiled-coil and C2 domain-containing protein 1B OS=Homo sapiens OX=9606 GN=CC2D1B PE=1 SV=1" "0.000" "False" "11.888" "6" "5" "5" "5" "858" "94.2" "5.26" "12.96" "5" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00168, Pf21528" "200014" "ENSG00000154222" "CC2D1B" "hsa:200014; Q49AE8; Q5T0F8; Q5T0F9; Q5T0G0; Q6ZNQ1; Q96AP3; Q96I04; Q96JJ1" "" "Sealing of the nuclear envelope (NE) by ESCRT-III" "1" "0" "1.103" "1.008" "0.998" "1.114" "1.029" "1.063" "0.987" "1.028" "1.114" "204.5" "225.7" "206.3" "204.2" "227.9" "210.5" "217.5" "201.8" "210.3" "227.8" "" "" "" "" "" "" "" "" "" "" "191.7" "186.7" "191.5" "157.9" "194.3" "201.1" "198.7" "179.2" "210.3" "219.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6827826663467104318" "False" "High" "IsMasterProtein" "Q9UK41" "Vacuolar protein sorting-associated protein 28 homolog OS=Homo sapiens OX=9606 GN=VPS28 PE=1 SV=1" "0.000" "False" "11.884" "19" "4" "4" "4" "221" "25.4" "5.54" "8.74" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03997" "51160" "ENSG00000160948; ENSG00000285339" "VPS28" "hsa:51160; Q86VK0; Q9UK41" "7q11.23 copy number variation syndrome" "HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy" "6" "0" "0.992" "0.977" "1.341" "1.101" "1.071" "1.068" "1.054" "1.017" "1.146" "67.1" "66.6" "65.5" "90.0" "73.9" "71.9" "71.7" "70.8" "68.3" "76.9" "" "" "" "" "" "" "" "" "" "" "62.9" "55.1" "60.8" "69.6" "63.0" "68.7" "65.5" "62.8" "68.3" "74.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8411894831205011543" "False" "High" "IsMasterProtein" "Q7L8J4" "SH3 domain-binding protein 5-like OS=Homo sapiens OX=9606 GN=SH3BP5L PE=1 SV=1" "0.000" "False" "11.879" "11" "5" "6" "5" "393" "43.5" "5.77" "9.56" "5" "signal transduction" "other cell component" "enzyme regulator activity" "Pf05276" "80851" "ENSG00000175137" "SH3BP5L" "B4DQ94; hsa:80851; Q7L8J4; Q96FI5; Q9BQH8; Q9C0E3" "" "" "0" "0" "1.108" "1.067" "1.128" "1.063" "1.056" "1.067" "1.008" "1.090" "1.115" "607.5" "673.2" "648.0" "685.2" "645.9" "641.5" "648.1" "612.2" "662.0" "677.6" "" "" "" "" "" "" "" "" "" "" "569.2" "557.0" "601.6" "529.7" "550.5" "612.9" "592.2" "543.6" "662.0" "652.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6811152372553307115" "False" "High" "IsMasterProtein" "Q9Y2X3" "Nucleolar protein 58 OS=Homo sapiens OX=9606 GN=NOP58 PE=1 SV=1" "0.000" "False" "11.872" "9" "4" "4" "4" "529" "59.5" "8.92" "12.60" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01798, Pf08156" "51602" "ENSG00000055044" "NOP58" "hsa:51602; Q53SA4; Q6PK08; Q9P036; Q9UFN3; Q9Y2X3" "" "Major pathway of rRNA processing in the nucleolus and cytosol; SUMOylation of RNA binding proteins; rRNA modification in the nucleus and cytosol" "3" "0" "1.065" "1.073" "0.992" "1.044" "1.076" "1.012" "1.043" "0.991" "1.027" "677.9" "721.7" "727.2" "672.1" "707.8" "729.1" "686.0" "707.3" "671.7" "696.2" "" "" "" "" "" "" "" "" "" "" "635.2" "597.2" "675.1" "519.6" "603.3" "696.6" "626.8" "628.0" "671.7" "670.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7969959000989021007" "False" "High" "IsMasterProtein" "P38935" "DNA-binding protein SMUBP-2 OS=Homo sapiens OX=9606 GN=IGHMBP2 PE=1 SV=3" "0.000" "False" "11.856" "4" "4" "4" "4" "993" "109.1" "8.97" "11.53" "4" "cell organization and biogenesis;RNA metabolism OR transcription" "nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf01424, Pf01428, Pf13086, Pf13087, Pf21138" "3508" "ENSG00000132740" "IGHMBP2" "A0PJD2; hsa:3508; P38935; Q00443; Q14177" "" "" "0" "0" "1.152" "1.014" "1.154" "1.216" "1.149" "1.196" "1.177" "1.192" "1.066" "209.1" "240.8" "212.1" "241.3" "254.3" "240.3" "250.1" "246.2" "249.2" "222.9" "" "" "" "" "" "" "" "" "" "" "195.9" "199.2" "196.9" "186.5" "216.8" "229.6" "228.5" "218.6" "249.2" "214.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8295272483259113664" "False" "High" "IsMasterProtein" "Q9Y333" "U6 snRNA-associated Sm-like protein LSm2 OS=Homo sapiens OX=9606 GN=LSM2 PE=1 SV=1" "0.000" "False" "11.845" "47" "4" "5" "4" "95" "10.8" "6.52" "16.41" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "57819" "ENSG00000172850; ENSG00000204392; ENSG00000224979; ENSG00000225998; ENSG00000231502; ENSG00000236826" "LSM2" "hsa:57819; Q6FGG1; Q9Y333" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "3" "0" "0.975" "1.074" "1.062" "1.020" "1.032" "1.083" "1.071" "1.014" "1.047" "418.6" "408.3" "449.8" "444.4" "426.9" "432.2" "453.2" "448.2" "424.5" "438.3" "" "" "" "" "" "" "" "" "" "" "392.3" "337.9" "417.6" "343.6" "363.9" "412.9" "414.1" "398.0" "424.5" "422.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6026735558710273601" "False" "High" "IsMasterProtein" "P36507" "Dual specificity mitogen-activated protein kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP2K2 PE=1 SV=1" "0.000" "False" "11.835" "9" "4" "5" "4" "400" "44.4" "6.55" "20.77" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "5605" "ENSG00000126934" "MAP2K2" "hsa:5605; P36507" "IL-5 signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Amyotrophic lateral sclerosis (ALS); Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; IL6 signaling pathway; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Kallmann syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "Signaling by BRAF and RAF1 fusions; Uptake and function of anthrax toxins; Signal transduction by L1; RAF activation; MAPK1 (ERK2) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Negative feedback regulation of MAPK pathway; Signaling by MAP2K mutants" "88" "0" "0.960" "1.024" "0.965" "0.973" "0.981" "0.923" "0.934" "0.991" "1.000" "885.4" "849.9" "907.1" "854.8" "861.2" "869.0" "817.3" "826.9" "877.7" "885.8" "" "" "" "" "" "" "" "" "" "" "829.6" "703.3" "842.1" "660.8" "734.1" "830.2" "746.8" "734.2" "877.7" "852.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2753103137801597372" "False" "High" "IsMasterProtein" "Q99618" "Cell division cycle-associated protein 3 OS=Homo sapiens OX=9606 GN=CDCA3 PE=1 SV=1" "0.000" "False" "11.835" "16" "4" "4" "4" "268" "29.0" "6.43" "13.39" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "" "" "83461" "ENSG00000111665" "CDCA3" "A8K5V6; D3DUS6; hsa:83461; Q99618" "" "" "0" "0" "1.122" "0.998" "1.055" "1.043" "1.031" "1.057" "1.059" "1.004" "1.021" "231.3" "259.7" "230.9" "244.2" "241.3" "238.5" "244.5" "245.0" "232.3" "236.3" "" "" "" "" "" "" "" "" "" "" "216.8" "214.9" "214.4" "188.8" "205.6" "227.9" "223.4" "217.5" "232.3" "227.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7634397569492690707" "False" "High" "IsMasterProtein" "Q96HY7" "2-oxoadipate dehydrogenase complex component E1 OS=Homo sapiens OX=9606 GN=DHTKD1 PE=1 SV=2" "0.000" "False" "11.826" "5" "5" "5" "5" "919" "103.0" "6.93" "17.82" "5" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00676, Pf02779, Pf16870" "55526" "ENSG00000181192" "DHTKD1" "hsa:55526; Q68CU5; Q96HY7; Q9BUM8; Q9HCE2" "" "Glyoxylate metabolism and glycine degradation" "1" "0" "1.014" "1.086" "1.062" "1.041" "1.062" "0.978" "1.016" "1.039" "1.050" "886.1" "898.2" "962.5" "941.0" "922.5" "941.4" "866.8" "900.6" "920.7" "930.4" "" "" "" "" "" "" "" "" "" "" "830.3" "743.3" "893.5" "727.4" "786.3" "899.4" "792.0" "799.7" "920.7" "895.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4718065310323386899" "False" "High" "IsMasterProtein" "Q5VSL9" "Striatin-interacting protein 1 OS=Homo sapiens OX=9606 GN=STRIP1 PE=1 SV=1" "0.000" "False" "11.825" "6" "4" "5" "4" "837" "95.5" "6.29" "12.51" "4" "cell organization and biogenesis;other biological processes" "cytosol;nucleus" "other molecular function" "Pf07923, Pf11882" "85369" "ENSG00000143093" "STRIP1" "hsa:85369; Q0V925; Q5VSL8; Q5VSL9; Q658K2; Q6ZV31; Q8N598; Q96SN2; Q9C0A2" "" "" "0" "0" "0.935" "0.990" "1.039" "1.151" "1.090" "1.129" "1.075" "1.061" "1.116" "74.4" "69.6" "73.6" "77.2" "85.6" "81.1" "83.9" "79.9" "78.9" "83.0" "" "" "" "" "" "" "" "" "" "" "69.7" "57.6" "68.3" "59.7" "72.9" "77.5" "76.7" "71.0" "78.9" "79.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2950951748836187489" "False" "High" "IsMasterProtein" "Q96MG7" "Non-structural maintenance of chromosomes element 3 homolog OS=Homo sapiens OX=9606 GN=NSMCE3 PE=1 SV=1" "0.000" "False" "11.798" "16" "4" "4" "4" "304" "34.3" "9.28" "10.53" "4" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01454" "56160" "ENSG00000185115; ENSG00000282130" "NSMCE3" "hsa:56160; Q8IW16; Q8TEI6; Q96MG7; Q9H214" "15q11q13 copy number variation" "SUMOylation of DNA damage response and repair proteins" "2" "0" "1.014" "1.006" "1.164" "1.086" "1.063" "1.138" "1.069" "1.041" "1.075" "355.5" "360.4" "357.8" "413.8" "386.2" "378.0" "404.5" "379.9" "370.1" "382.2" "" "" "" "" "" "" "" "" "" "" "333.1" "298.2" "332.1" "319.9" "329.2" "361.1" "369.6" "337.3" "370.1" "368.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "876115928982754265" "False" "High" "IsMasterProtein" "P00519" "Tyrosine-protein kinase ABL1 OS=Homo sapiens OX=9606 GN=ABL1 PE=1 SV=4" "0.000" "False" "11.785" "4" "5" "5" "5" "1130" "122.8" "8.66" "14.09" "5" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714, Pf08919" "25" "ENSG00000097007" "ABL1" "A3KFJ3; hsa:25; P00519; Q13869; Q13870; Q16133; Q17R61; Q45F09" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; Retinoblastoma gene in cancer; ATM signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Imatinib and chronic myeloid leukemia; VEGFA-VEGFR2 signaling; Ras signaling; Acute viral myocarditis; EGF/EGFR signaling pathway; Macrophage-stimulating protein (MSP) signaling network map; 5q35 copy number variation; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RHO GTPases Activate WASPs and WAVEs; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Myogenesis; Cyclin D associated events in G1; Factors involved in megakaryocyte development and platelet production; RUNX2 regulates osteoblast differentiation; HDR through Single Strand Annealing (SSA); Role of ABL in ROBO-SLIT signaling" "30" "0" "0.991" "0.984" "1.023" "0.989" "1.037" "1.126" "0.972" "1.020" "1.056" "432.8" "428.9" "425.7" "442.6" "427.9" "449.0" "487.2" "420.9" "441.6" "457.3" "" "" "" "" "" "" "" "" "" "" "405.5" "354.9" "395.2" "342.1" "364.7" "429.0" "445.2" "373.7" "441.6" "440.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5017693853216972141" "False" "High" "IsMasterProtein" "Q969S3" "Cytoplasmic 60S subunit biogenesis factor ZNF622 OS=Homo sapiens OX=9606 GN=ZNF622 PE=1 SV=1" "0.000" "False" "11.781" "8" "4" "4" "4" "477" "54.2" "6.15" "12.69" "4" "signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf12171, Pf12756" "90441" "ENSG00000173545" "ZNF622" "hsa:90441; Q969S3" "" "" "0" "0" "1.092" "1.081" "1.366" "1.350" "1.340" "2.001" "1.833" "1.807" "1.440" "566.9" "619.2" "612.7" "774.5" "765.3" "759.8" "1134.5" "1039.3" "1024.1" "816.3" "" "" "" "" "" "" "" "" "" "" "531.2" "512.4" "568.8" "598.7" "652.3" "726.0" "1036.6" "922.8" "1024.1" "785.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7691661012823891973" "False" "High" "IsMasterProtein" "P54278" "Mismatch repair endonuclease PMS2 OS=Homo sapiens OX=9606 GN=PMS2 PE=1 SV=2" "0.000" "False" "11.780" "5" "4" "4" "4" "862" "95.7" "6.86" "13.69" "4" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01119, Pf08676, Pf13589" "5395" "ENSG00000122512" "PMS2" "B2R610; hsa:5395; P54278; Q52LH6; Q5FBW9; Q5FBX1; Q5FBX2; Q75MR2" "Male infertility; DNA repair pathways, full network; DNA mismatch repair" "TP53 Regulates Transcription of DNA Repair Genes; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MLH1; Defective Mismatch Repair Associated With PMS2" "8" "0" "1.110" "1.046" "1.106" "0.995" "1.087" "1.046" "1.037" "1.050" "1.057" "240.9" "267.4" "252.0" "266.4" "239.7" "261.9" "252.0" "249.8" "253.0" "254.7" "" "" "" "" "" "" "" "" "" "" "225.7" "221.2" "234.0" "205.9" "204.3" "250.2" "230.2" "221.8" "253.0" "245.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4323505555585634337" "False" "High" "IsMasterProtein" "Q9UKS7" "Zinc finger protein Helios OS=Homo sapiens OX=9606 GN=IKZF2 PE=1 SV=2" "0.000" "False" "11.739" "7" "4" "5" "2" "526" "59.5" "6.77" "14.89" "4" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "22807" "ENSG00000030419" "IKZF2" "hsa:22807; Q53YJ5; Q6PQC5; Q6PQC6; Q6PQC7; Q6PQC8; Q6PQD0; Q6PQD1; Q8N6S1; Q9UKS7" "" "" "0" "2" "1.047" "1.012" "1.080" "1.064" "1.082" "1.185" "1.128" "1.191" "1.160" "192.3" "201.3" "194.7" "207.8" "204.6" "208.2" "227.9" "217.0" "229.0" "223.2" "" "" "" "" "" "" "" "" "" "" "180.2" "166.6" "180.7" "160.6" "174.4" "198.9" "208.3" "192.7" "229.0" "214.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4643868144451564503" "False" "High" "IsMasterProtein" "P41567" "Eukaryotic translation initiation factor 1 OS=Homo sapiens OX=9606 GN=EIF1 PE=1 SV=1" "0.000" "False" "11.735" "27" "2" "3" "2" "113" "12.7" "7.44" "13.45" "2" "protein metabolism;other metabolic processes;other biological processes" "translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01253" "10209" "ENSG00000173812" "EIF1" "hsa:10209; P41567; Q9UNQ9" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "" "2" "0" "0.981" "0.954" "0.908" "1.034" "1.065" "0.997" "1.040" "0.954" "1.004" "415.2" "407.2" "396.0" "377.0" "429.4" "442.3" "414.2" "431.7" "396.3" "416.8" "" "" "" "" "" "" "" "" "" "" "389.1" "337.0" "367.6" "291.4" "366.0" "422.5" "378.5" "383.3" "396.3" "401.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4842637441270179392" "False" "High" "IsMasterProtein" "Q9BU76" "Multiple myeloma tumor-associated protein 2 OS=Homo sapiens OX=9606 GN=MMTAG2 PE=1 SV=1" "0.000" "False" "11.728" "17" "4" "4" "4" "263" "29.4" "10.02" "14.07" "4" "" "non-structural extracellular;other cell component" "" "Pf10159" "79169" "ENSG00000143793" "MMTAG2" "hsa:79169; Q6P5Y0; Q6ZTZ6; Q6ZWA6; Q8IZH3; Q9BU76" "" "Neutrophil degranulation" "1" "0" "1.062" "1.019" "1.184" "1.250" "1.064" "1.793" "1.891" "1.900" "1.325" "371.4" "394.3" "378.5" "439.6" "464.1" "395.1" "665.9" "702.2" "705.8" "492.2" "" "" "" "" "" "" "" "" "" "" "348.0" "326.3" "351.4" "339.8" "395.6" "377.5" "608.5" "623.5" "705.8" "474.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7431440183355440202" "False" "High" "IsMasterProtein" "Q9ULL5" "Proline-rich protein 12 OS=Homo sapiens OX=9606 GN=PRR12 PE=1 SV=3" "0.000" "False" "11.709" "2" "5" "6" "5" "2036" "210.9" "7.87" "16.37" "5" "" "nucleus;other cell component" "" "Pf13926" "57479" "ENSG00000126464" "PRR12" "E9PB06; hsa:57479; Q8N4J6; Q9ULL5" "" "" "0" "0" "1.060" "1.035" "1.094" "1.041" "1.014" "1.023" "1.006" "1.024" "1.020" "581.1" "615.7" "601.5" "636.0" "605.2" "589.0" "594.8" "584.7" "595.0" "592.6" "" "" "" "" "" "" "" "" "" "" "544.5" "509.5" "558.4" "491.6" "515.9" "562.8" "543.4" "519.2" "595.0" "570.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4043384267201458756" "False" "High" "IsMasterProtein" "Q8TBX8" "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma OS=Homo sapiens OX=9606 GN=PIP4K2C PE=1 SV=3" "0.000" "False" "11.708" "12" "5" "5" "5" "421" "47.3" "6.84" "13.56" "5" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf01504" "79837" "ENSG00000166908" "PIP4K2C" "B2RDL3; B4DM11; B4DY44; hsa:79837; Q8TBX8; Q9H6N2" "Regulation of actin cytoskeleton" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "5" "0" "0.886" "0.986" "0.893" "0.938" "0.948" "0.799" "0.899" "0.840" "0.943" "743.9" "658.8" "733.6" "664.1" "697.9" "705.6" "594.4" "668.7" "624.8" "701.6" "" "" "" "" "" "" "" "" "" "" "697.1" "545.1" "681.0" "513.4" "594.9" "674.1" "543.1" "593.8" "624.8" "675.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5010086175827698668" "False" "High" "IsMasterProtein" "P42575" "Caspase-2 OS=Homo sapiens OX=9606 GN=CASP2 PE=1 SV=2" "0.000" "False" "11.708" "10" "4" "5" "4" "452" "50.7" "6.81" "15.08" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00619, Pf00656" "835" "ENSG00000106144" "CASP2" "A8K5F9; D3DXD6; E9PDN0; hsa:835; P42575; P42576; Q59F21; Q7KZL6; Q86UJ3; Q9BUP7; Q9BZK9; Q9BZL0" "Apoptosis modulation and signaling; Parkinson's disease pathway; Apoptosis; Apoptosis modulation by HSP70; Acute viral myocarditis" "TP53 Regulates Transcription of Caspase Activators and Caspases; NOD1/2 Signaling Pathway; NADE modulates death signalling" "8" "0" "1.020" "1.074" "0.892" "0.867" "0.919" "0.656" "0.633" "0.653" "0.912" "692.1" "705.7" "743.6" "617.6" "599.8" "635.8" "454.0" "438.4" "451.8" "631.0" "" "" "" "" "" "" "" "" "" "" "648.5" "584.0" "690.3" "477.4" "511.3" "607.4" "414.8" "389.3" "451.8" "607.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3153714913884480543" "False" "High" "IsMasterProtein" "Q8TAE8" "Large ribosomal subunit protein mL64 OS=Homo sapiens OX=9606 GN=GADD45GIP1 PE=1 SV=1" "0.000" "False" "11.702" "27" "5" "5" "5" "222" "25.4" "10.02" "15.03" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf10147" "90480" "ENSG00000179271" "GADD45GIP1" "hsa:90480; Q8IVM3; Q8TAE8; Q8TE51; Q969P9; Q9BSM6" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.088" "0.961" "0.979" "1.094" "1.101" "1.022" "1.017" "1.009" "1.074" "607.2" "660.7" "583.7" "594.2" "664.1" "668.5" "620.2" "617.5" "612.6" "652.4" "" "" "" "" "" "" "" "" "" "" "568.9" "546.7" "541.9" "459.3" "566.1" "638.7" "566.7" "548.3" "612.6" "628.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1607467674154274672" "False" "High" "IsMasterProtein" "Q8N4Q1" "Mitochondrial intermembrane space import and assembly protein 40 OS=Homo sapiens OX=9606 GN=CHCHD4 PE=1 SV=1" "0.000" "False" "11.690" "25" "3" "4" "3" "142" "16.0" "4.31" "18.26" "3" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "mitochondrion" "other molecular function" "Pf06747" "131474" "ENSG00000163528" "CHCHD4" "A8K3Z9; hsa:131474; Q8N4Q1; Q96AI2; Q96MY6" "" "Mitochondrial protein import" "1" "0" "1.011" "0.995" "0.979" "1.065" "0.999" "0.987" "1.026" "0.970" "1.061" "495.9" "501.2" "493.6" "485.4" "528.2" "495.5" "489.3" "509.0" "481.2" "526.1" "" "" "" "" "" "" "" "" "" "" "464.7" "414.7" "458.3" "375.2" "450.2" "473.4" "447.1" "452.0" "481.2" "506.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1614464300928510251" "False" "High" "IsMasterProtein" "P55854" "Small ubiquitin-related modifier 3 OS=Homo sapiens OX=9606 GN=SUMO3 PE=1 SV=2" "0.000" "False" "11.690" "26" "3" "8" "1" "103" "11.6" "5.49" "24.46" "3" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11976" "6612" "ENSG00000184900" "SUMO3" "B2R5X4; B4DUW4; hsa:6612; P55854; Q53HI9; Q6FGD4; Q9BWR4" "Exercise-induced circadian regulation" "SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER; SUMOylation of immune response proteins; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "12" "2" "0.955" "0.984" "0.926" "0.899" "0.889" "0.952" "0.929" "0.857" "0.936" "856.5" "818.0" "842.9" "793.1" "770.4" "761.4" "815.5" "796.0" "733.9" "801.8" "" "" "" "" "" "" "" "" "" "" "802.6" "676.9" "782.6" "613.1" "656.7" "727.5" "745.1" "706.8" "733.9" "772.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-345660777743534482" "False" "High" "IsMasterProtein" "Q9NPJ6" "Mediator of RNA polymerase II transcription subunit 4 OS=Homo sapiens OX=9606 GN=MED4 PE=1 SV=1" "0.000" "False" "11.676" "15" "4" "4" "4" "270" "29.7" "5.10" "14.47" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf10018" "29079" "ENSG00000136146" "MED4" "B4DX67; hsa:29079; Q53GB4; Q53H68; Q5T912; Q6FHC4; Q6IA79; Q9BS95; Q9NPJ6; Q9NYR5" "" "PPARA activates gene expression; Generic Transcription Pathway; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "4" "0" "1.058" "0.916" "1.032" "1.114" "1.121" "0.989" "1.019" "1.058" "1.056" "325.6" "344.5" "298.3" "336.0" "362.6" "365.0" "322.1" "331.8" "344.6" "343.7" "" "" "" "" "" "" "" "" "" "" "305.1" "285.1" "276.9" "259.8" "309.1" "348.7" "294.3" "294.6" "344.6" "330.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6698557715673705148" "False" "High" "IsMasterProtein" "Q6P3W7" "SCY1-like protein 2 OS=Homo sapiens OX=9606 GN=SCYL2 PE=1 SV=1" "0.000" "False" "11.675" "4" "4" "4" "4" "929" "103.6" "8.22" "13.01" "4" "cell-cell signaling;transport;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069" "55681" "ENSG00000136021" "SCYL2" "A8KAB5; hsa:55681; Q6P3W7; Q96EF4; Q96ST4; Q9H7V5; Q9NVH3; Q9P2I7" "" "" "0" "0" "1.019" "1.097" "1.077" "1.101" "1.017" "1.055" "1.139" "1.101" "1.115" "76.0" "77.4" "83.4" "81.9" "83.7" "77.3" "80.1" "86.6" "83.7" "84.8" "" "" "" "" "" "" "" "" "" "" "71.2" "64.1" "77.4" "63.3" "71.3" "73.8" "73.2" "76.9" "83.7" "81.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5299507636150983864" "False" "High" "IsMasterProtein" "Q9Y697" "Cysteine desulfurase OS=Homo sapiens OX=9606 GN=NFS1 PE=1 SV=3" "0.000" "False" "11.671" "10" "4" "5" "4" "457" "50.2" "8.31" "18.77" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00266" "9054" "ENSG00000244005" "NFS1" "B3KMA5; B4DXK9; E1P5R8; F5GYK5; hsa:9054; Q6P0L8; Q9NTZ5; Q9Y481; Q9Y697" "Iron-sulfur cluster biogenesis" "" "1" "0" "0.992" "0.996" "0.986" "1.029" "0.975" "0.984" "1.040" "1.007" "0.984" "1009.9" "1001.9" "1005.7" "996.1" "1039.2" "984.7" "994.1" "1050.6" "1017.5" "993.8" "" "" "" "" "" "" "" "" "" "" "946.3" "829.1" "933.6" "770.0" "885.8" "940.8" "908.3" "932.8" "1017.5" "956.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "558828740565352174" "False" "High" "IsMasterProtein" "Q2VPK5" "Cytoplasmic tRNA 2-thiolation protein 2 OS=Homo sapiens OX=9606 GN=CTU2 PE=1 SV=1" "0.000" "False" "11.671" "7" "4" "5" "4" "515" "56.1" "6.32" "16.53" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf10288" "348180" "ENSG00000174177" "CTU2" "B2RXK0; hsa:348180; Q0P511; Q2VPK5; Q66K78; Q6P4C8; Q86SV4" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.007" "1.013" "1.037" "0.997" "0.998" "1.004" "0.995" "0.968" "0.977" "428.4" "431.5" "433.9" "444.2" "427.1" "427.7" "430.0" "426.4" "414.8" "418.7" "" "" "" "" "" "" "" "" "" "" "401.4" "357.1" "402.8" "343.4" "364.1" "408.6" "392.9" "378.6" "414.8" "403.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2898221823971910502" "False" "High" "IsMasterProtein" "Q96H79" "Zinc finger CCCH-type antiviral protein 1-like OS=Homo sapiens OX=9606 GN=ZC3HAV1L PE=1 SV=2" "0.000" "False" "11.670" "16" "5" "6" "5" "300" "32.9" "8.13" "11.60" "5" "" "cytosol" "" "Pf18606" "92092" "ENSG00000146858" "ZC3HAV1L" "hsa:92092; Q8WUD9; Q96H79" "" "" "0" "0" "1.031" "1.009" "0.959" "0.926" "0.964" "0.966" "0.890" "0.981" "0.970" "304.7" "314.0" "307.4" "292.1" "282.1" "293.7" "294.2" "271.0" "299.0" "295.4" "" "" "" "" "" "" "" "" "" "" "285.5" "259.8" "285.4" "225.8" "240.4" "280.6" "268.8" "240.7" "299.0" "284.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6043879365308815932" "False" "High" "IsMasterProtein" "O75818" "Ribonuclease P protein subunit p40 OS=Homo sapiens OX=9606 GN=RPP40 PE=1 SV=3" "0.000" "False" "11.667" "14" "5" "5" "5" "363" "41.8" "6.67" "15.29" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08584" "10799" "ENSG00000124787" "RPP40" "hsa:10799; O75818; Q5VX97; Q8WVK8" "" "tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol" "2" "0" "1.030" "1.059" "1.131" "1.026" "1.021" "1.029" "1.054" "1.117" "1.034" "724.0" "746.0" "766.5" "819.1" "743.0" "739.2" "744.6" "763.3" "808.4" "748.5" "" "" "" "" "" "" "" "" "" "" "678.4" "617.3" "711.6" "633.2" "633.3" "706.3" "680.4" "677.8" "808.4" "720.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5107333921582106986" "False" "High" "IsMasterProtein" "Q9UPR3" "Nonsense-mediated mRNA decay factor SMG5 OS=Homo sapiens OX=9606 GN=SMG5 PE=1 SV=3" "0.000" "False" "11.635" "4" "5" "6" "5" "1016" "113.9" "5.91" "16.63" "5" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10373, Pf10374, Pf13638" "23381" "ENSG00000198952" "SMG5" "D3DVB7; hsa:23381; Q5QJE7; Q659C7; Q8IXC0; Q8IY09; Q96IJ7; Q9UPR3" "" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "1" "0" "0.954" "0.998" "0.977" "0.976" "1.022" "0.916" "0.948" "0.991" "0.995" "457.0" "435.8" "456.2" "446.5" "446.2" "466.9" "418.8" "433.3" "452.8" "454.9" "" "" "" "" "" "" "" "" "" "" "428.2" "360.6" "423.5" "345.2" "380.3" "446.0" "382.6" "384.7" "452.8" "438.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8524788288681439212" "False" "High" "IsMasterProtein" "O15164" "Transcription intermediary factor 1-alpha OS=Homo sapiens OX=9606 GN=TRIM24 PE=1 SV=3" "0.000" "False" "11.626" "4" "4" "5" "3" "1050" "116.8" "7.11" "14.39" "4" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;kinase activity;other molecular function" "Pf00439, Pf00628, Pf00643" "8805" "ENSG00000122779" "TRIM24" "A4D1R7; A4D1R8; hsa:8805; O15164; O95854" "" "Signaling by BRAF and RAF1 fusions; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "3" "0" "1.146" "1.038" "1.258" "1.209" "1.141" "1.404" "1.302" "1.257" "1.167" "183.0" "209.6" "189.9" "230.2" "221.2" "208.7" "256.9" "238.1" "230.0" "213.4" "" "" "" "" "" "" "" "" "" "" "171.4" "173.5" "176.3" "177.9" "188.5" "199.4" "234.7" "211.4" "230.0" "205.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4646306898255403066" "False" "High" "IsMasterProtein" "Q96FF9" "Sororin OS=Homo sapiens OX=9606 GN=CDCA5 PE=1 SV=1" "0.000" "False" "11.625" "17" "5" "5" "5" "252" "27.6" "9.61" "17.34" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09666" "113130" "ENSG00000146670" "CDCA5" "A8K625; hsa:113130; Q96FF9" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion" "3" "0" "1.070" "1.072" "1.019" "1.090" "1.103" "0.965" "1.058" "1.061" "1.066" "403.5" "431.6" "432.6" "410.9" "439.9" "444.8" "389.3" "426.7" "427.9" "429.9" "" "" "" "" "" "" "" "" "" "" "378.0" "357.2" "401.6" "317.7" "375.0" "425.0" "355.8" "378.9" "427.9" "414.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8759036951300063870" "False" "High" "IsMasterProtein" "Q6ZT12" "E3 ubiquitin-protein ligase UBR3 OS=Homo sapiens OX=9606 GN=UBR3 PE=1 SV=2" "0.000" "False" "11.623" "2" "4" "5" "4" "1888" "212.3" "6.10" "11.94" "4" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;other cell component" "other molecular function" "Pf02207, Pf18995" "130507" "ENSG00000144357" "UBR3" "B4DZR7; Q2KHN5; Q6ZR55; Q6ZSC2; Q6ZT12; Q8IVE7; Q8ND96" "" "" "0" "0" "1.053" "1.009" "1.071" "1.012" "1.040" "1.040" "0.983" "1.021" "1.006" "131.9" "138.9" "133.1" "141.3" "133.5" "137.2" "137.2" "129.7" "134.7" "132.8" "" "" "" "" "" "" "" "" "" "" "123.6" "115.0" "123.6" "109.3" "113.8" "131.1" "125.3" "115.1" "134.7" "127.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2028658389890867927" "False" "High" "IsMasterProtein" "Q99708" "DNA endonuclease RBBP8 OS=Homo sapiens OX=9606 GN=RBBP8 PE=1 SV=2" "0.000" "False" "11.613" "5" "5" "7" "5" "897" "101.9" "6.30" "19.25" "5" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08573, Pf10482" "5932" "ENSG00000101773" "RBBP8" "A6NKN2; A8K8W6; E7ETY1; hsa:5932; O75371; Q8NHQ3; Q99708" "ATM signaling in development and disease" "Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Transcriptional Regulation by E2F6; Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through MMEJ (alt-NHEJ)" "18" "0" "1.053" "1.021" "1.089" "1.016" "1.088" "1.020" "1.052" "1.000" "1.038" "432.7" "455.8" "441.8" "471.2" "439.8" "470.6" "441.2" "455.1" "432.7" "449.2" "" "" "" "" "" "" "" "" "" "" "405.4" "377.2" "410.2" "364.2" "374.8" "449.6" "403.1" "404.1" "432.7" "432.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2601253202356678168" "False" "High" "IsMasterProtein" "P31937" "3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HIBADH PE=1 SV=2" "0.000" "False" "11.600" "16" "3" "5" "3" "336" "35.3" "8.13" "17.09" "3" "other metabolic processes" "mitochondrion" "other molecular function" "Pf03446, Pf14833" "11112" "ENSG00000106049" "HIBADH" "hsa:11112; P31937; Q546Z2; Q9UDN3" "Amino acid metabolism" "Branched-chain amino acid catabolism" "2" "0" "0.985" "0.961" "1.069" "1.042" "0.989" "1.023" "1.031" "1.003" "1.019" "692.2" "682.0" "665.2" "739.8" "721.1" "684.6" "707.8" "714.0" "694.4" "705.2" "" "" "" "" "" "" "" "" "" "" "648.6" "564.3" "617.5" "571.9" "614.6" "654.0" "646.7" "634.0" "694.4" "679.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8041398226355410347" "False" "High" "IsMasterProtein" "Q9NUL5" "Shiftless antiviral inhibitor of ribosomal frameshifting protein OS=Homo sapiens OX=9606 GN=SHFL PE=1 SV=2" "0.000" "False" "11.592" "15" "4" "4" "4" "291" "33.1" "7.25" "11.51" "4" "stress response;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf15135" "55337" "ENSG00000130813" "SHFL" "A8MQT9; hsa:55337; Q4G188; Q8IYH6; Q8N8V1; Q9NUL5" "" "" "0" "0" "0.916" "0.954" "1.103" "0.997" "0.955" "1.012" "1.128" "0.851" "1.016" "109.1" "99.9" "104.1" "120.3" "108.7" "104.2" "110.3" "123.0" "92.8" "110.8" "" "" "" "" "" "" "" "" "" "" "102.2" "82.7" "96.6" "93.0" "92.7" "99.5" "100.8" "109.3" "92.8" "106.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2341580766278944773" "False" "High" "IsMasterProtein" "P15056" "Serine/threonine-protein kinase B-raf OS=Homo sapiens OX=9606 GN=BRAF PE=1 SV=4" "0.000" "False" "11.579" "5" "4" "6" "2" "766" "84.4" "7.53" "18.25" "4" "cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00130, Pf02196, Pf07714" "673" "ENSG00000157764" "BRAF" "A4D1T4; B6HY61; B6HY62; B6HY63; B6HY64; B6HY65; B6HY66; hsa:673; P15056; Q13878; Q3MIN6; Q9UDP8; Q9Y6T3" "Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Alzheimer's disease and miRNA effects; Pilocytic astrocytoma; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Polycystic kidney disease pathway; Bladder cancer; Focal adhesion; BDNF-TrkB signaling; MAPK signaling pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Endometrial cancer; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Rett syndrome; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Fragile X syndrome; Hepatitis B infection; Melanoma; EGFR tyrosine kinase inhibitor resistance; Regucalcin in proximal tubule epithelial kidney cells; MAPK pathway in congenital thyroid cancer; TCA cycle in senescence; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; ErbB signaling pathway; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling" "Signaling by BRAF and RAF1 fusions; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Spry regulation of FGF signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; ARMS-mediated activation; Signalling to p38 via RIT and RIN; Negative feedback regulation of MAPK pathway" "56" "0" "0.943" "0.944" "0.931" "0.994" "1.019" "0.904" "0.934" "0.872" "0.963" "415.4" "391.7" "392.2" "386.5" "413.0" "423.1" "375.4" "388.1" "362.3" "400.1" "" "" "" "" "" "" "" "" "" "" "389.2" "324.1" "364.1" "298.8" "352.0" "404.2" "343.0" "344.6" "362.3" "385.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5444198170657218689" "False" "High" "IsMasterProtein" "O14508" "Suppressor of cytokine signaling 2 OS=Homo sapiens OX=9606 GN=SOCS2 PE=1 SV=1" "0.000" "False" "11.567" "20" "5" "5" "5" "198" "22.2" "8.69" "15.46" "5" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf07525" "8835" "ENSG00000120833" "SOCS2" "A8K3D1; hsa:8835; O14508; O14542; O95102; Q9UKS5" "Leptin signaling pathway; Prolactin signaling pathway; Ectoderm differentiation; Leptin-insulin signaling overlap; JAK-STAT signaling in the regulation of beta cells" "Neddylation; Interleukin-7 signaling; Negative regulation of FLT3; Growth hormone receptor signaling" "9" "0" "0.901" "0.948" "0.852" "0.882" "0.981" "0.886" "0.908" "0.951" "0.950" "993.8" "895.3" "942.3" "847.1" "876.7" "975.3" "880.5" "902.0" "945.6" "943.7" "" "" "" "" "" "" "" "" "" "" "931.2" "740.9" "874.8" "654.9" "747.3" "931.8" "804.5" "800.9" "945.6" "908.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "469142345215753577" "False" "High" "IsMasterProtein" "Q9Y2R9" "Small ribosomal subunit protein uS7m OS=Homo sapiens OX=9606 GN=MRPS7 PE=1 SV=2" "0.000" "False" "11.558" "15" "3" "5" "3" "242" "28.1" "9.99" "15.49" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00177" "51081" "ENSG00000125445" "MRPS7" "B2R9N5; hsa:51081; Q53GD6; Q9Y2R9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.122" "1.086" "1.206" "1.125" "1.131" "1.078" "1.036" "1.044" "1.107" "368.5" "413.5" "400.3" "444.5" "414.6" "416.7" "397.1" "381.7" "384.6" "407.8" "" "" "" "" "" "" "" "" "" "" "345.3" "342.2" "371.6" "343.6" "353.4" "398.1" "362.9" "338.9" "384.6" "392.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-510169837627830895" "False" "High" "IsMasterProtein" "P49789" "Bis(5'-adenosyl)-triphosphatase OS=Homo sapiens OX=9606 GN=FHIT PE=1 SV=3" "0.000" "False" "11.544" "27" "4" "4" "4" "147" "16.8" "7.08" "11.28" "4" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01230" "2272" "ENSG00000189283" "FHIT" "A2IAS9; A2IAT0; A2IAT6; A8K1A9; hsa:2272; P49789; Q45QG9; Q6IU12" "Non-small cell lung cancer; Small cell lung cancer" "" "2" "0" "1.033" "0.982" "1.010" "0.959" "1.049" "0.937" "0.965" "0.997" "1.102" "344.7" "356.1" "338.5" "348.2" "330.7" "361.7" "323.1" "332.8" "343.6" "379.8" "" "" "" "" "" "" "" "" "" "" "323.0" "294.7" "314.3" "269.2" "281.9" "345.6" "295.2" "295.5" "343.6" "365.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6951101032549152638" "False" "High" "IsMasterProtein" "Q9BYD3" "Large ribosomal subunit protein uL4m OS=Homo sapiens OX=9606 GN=MRPL4 PE=1 SV=1" "0.000" "False" "11.529" "16" "4" "4" "4" "311" "34.9" "9.72" "13.04" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00573" "51073" "ENSG00000105364" "MRPL4" "A6NNV7; hsa:51073; Q9BW07; Q9BYD3; Q9H4N2; Q9Y317" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.048" "1.014" "1.155" "1.027" "1.071" "1.056" "0.992" "1.027" "0.982" "321.6" "337.0" "326.1" "371.5" "330.4" "344.4" "339.5" "319.1" "330.4" "315.8" "" "" "" "" "" "" "" "" "" "" "301.4" "278.9" "302.8" "287.2" "281.6" "329.1" "310.2" "283.4" "330.4" "304.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8619075754329803082" "False" "High" "IsMasterProtein" "P17275" "Transcription factor JunB OS=Homo sapiens OX=9606 GN=JUNB PE=1 SV=1" "0.000" "False" "11.529" "11" "4" "4" "3" "347" "35.9" "9.22" "16.26" "4" "cell cycle OR cell proliferation;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf03957" "3726" "ENSG00000171223" "JUNB" "hsa:3726; P17275; Q96GH3" "Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Photodynamic therapy-induced AP-1 survival signaling; IL6 signaling pathway; TGF-beta signaling pathway; Oxidative stress response; Host-pathogen interaction of human coronaviruses - MAPK signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Orexin receptor pathway; Osteoarthritic chondrocyte hypertrophy" "NGF-stimulated transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Interleukin-4 and Interleukin-13 signaling; Nuclear events stimulated by ALK signaling in cancer" "18" "0" "1.053" "0.999" "1.174" "1.114" "1.125" "1.130" "1.260" "1.113" "1.129" "563.5" "593.6" "563.2" "661.7" "628.0" "633.9" "636.7" "709.8" "627.2" "636.2" "" "" "" "" "" "" "" "" "" "" "528.0" "491.2" "522.8" "511.5" "535.3" "605.6" "581.8" "630.2" "627.2" "612.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4589433783542351991" "False" "High" "IsMasterProtein" "Q9NVU0" "DNA-directed RNA polymerase III subunit RPC5 OS=Homo sapiens OX=9606 GN=POLR3E PE=1 SV=1" "0.000" "False" "11.520" "6" "5" "6" "5" "708" "79.8" "6.47" "16.44" "5" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus" "" "Pf04801, Pf19725" "55718" "ENSG00000058600; ENSG00000284282" "POLR3E" "B4DL24; B4DUP6; H3BT11; hsa:55718; Q9BWF7; Q9H8W8; Q9H907; Q9NVU0; Q9P276" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "0.912" "0.970" "0.939" "0.924" "0.988" "0.930" "0.935" "0.908" "0.973" "749.9" "683.8" "727.6" "703.8" "692.9" "740.7" "697.2" "700.8" "681.2" "729.8" "" "" "" "" "" "" "" "" "" "" "702.6" "565.8" "675.5" "544.1" "590.6" "707.7" "637.1" "622.2" "681.2" "702.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6790579379401263319" "False" "High" "IsMasterProtein" "Q8IU85" "Calcium/calmodulin-dependent protein kinase type 1D OS=Homo sapiens OX=9606 GN=CAMK1D PE=1 SV=1" "0.000" "False" "11.518" "10" "4" "4" "4" "385" "42.9" "7.21" "14.52" "4" "other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "57118" "ENSG00000183049" "CAMK1D" "B0YIY0; hsa:57118; Q8IU85; Q9HD31" "" "" "0" "0" "1.065" "1.009" "1.110" "1.073" "1.029" "1.025" "0.997" "1.063" "1.076" "560.0" "596.6" "565.0" "621.7" "600.8" "576.0" "573.9" "558.3" "595.3" "602.7" "" "" "" "" "" "" "" "" "" "" "524.7" "493.6" "524.6" "480.6" "512.1" "550.3" "524.4" "495.7" "595.3" "580.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6567734872650185245" "False" "High" "IsMasterProtein" "C9JLW8" "Mapk-regulated corepressor-interacting protein 1 OS=Homo sapiens OX=9606 GN=MCRIP1 PE=1 SV=1" "0.000" "False" "11.510" "35" "3" "4" "3" "97" "10.9" "9.41" "15.81" "3" "other biological processes" "nucleus;other cell component" "" "Pf14799" "348262" "ENSG00000225663; ENSG00000288213" "MCRIP1" "C9JLW8; hsa:348262; Q6ZUL0" "" "" "0" "0" "0.962" "0.965" "0.997" "1.022" "0.982" "0.940" "0.972" "0.967" "0.975" "418.0" "401.9" "403.2" "416.9" "427.2" "410.3" "392.8" "406.2" "404.1" "407.5" "" "" "" "" "" "" "" "" "" "" "391.7" "332.6" "374.3" "322.3" "364.1" "392.0" "358.9" "360.7" "404.1" "392.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "258971474423548673" "False" "High" "IsMasterProtein" "Q14746" "Conserved oligomeric Golgi complex subunit 2 OS=Homo sapiens OX=9606 GN=COG2 PE=1 SV=1" "0.000" "False" "11.508" "6" "4" "4" "4" "738" "83.2" "6.62" "13.87" "4" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi" "other molecular function" "Pf06148, Pf12022" "22796" "ENSG00000135775" "COG2" "hsa:22796; Q14746; Q86U99" "" "Retrograde transport at the Trans-Golgi-Network; COPI-mediated anterograde transport; Intra-Golgi traffic" "3" "0" "1.040" "1.003" "0.946" "0.928" "1.047" "0.939" "0.976" "0.961" "1.048" "188.3" "195.8" "188.8" "178.1" "174.7" "197.0" "176.7" "183.8" "181.0" "197.3" "" "" "" "" "" "" "" "" "" "" "176.4" "162.0" "175.3" "137.7" "148.9" "188.2" "161.5" "163.2" "181.0" "190.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7235232019180232965" "False" "High" "IsMasterProtein" "A0A3B3IRV3" "Malignant T-cell-amplified sequence 2 OS=Homo sapiens OX=9606 GN=MCTS2 PE=1 SV=1" "0.000" "False" "11.497" "20" "3" "6" "1" "181" "20.3" "9.01" "15.79" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other cell component" "nucleic acid binding activity" "Pf01472, Pf17832" "" "ENSG00000101898" "MCTS2" "A0A3B3IRV3" "" "" "0" "0" "1.397" "1.342" "1.477" "1.120" "1.417" "1.348" "0.900" "1.208" "1.477" "18.9" "26.5" "25.4" "28.0" "21.2" "26.8" "25.5" "17.0" "22.9" "28.0" "" "" "" "" "" "" "" "" "" "" "17.7" "21.9" "23.6" "21.6" "18.1" "25.6" "23.3" "15.1" "22.9" "26.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5181742408378363027" "False" "High" "IsMasterProtein" "P62253" "Ubiquitin-conjugating enzyme E2 G1 OS=Homo sapiens OX=9606 GN=UBE2G1 PE=1 SV=3" "0.000" "False" "11.486" "28" "4" "7" "4" "170" "19.5" "5.30" "24.47" "4" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00179" "7326" "ENSG00000132388" "UBE2G1" "B2R7P2; D3DTK0; hsa:7326; P62253; Q99462" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "4" "0" "1.197" "0.968" "0.976" "0.945" "0.991" "1.286" "0.941" "0.983" "0.976" "264.6" "316.7" "256.1" "258.3" "250.1" "262.3" "340.3" "249.0" "260.2" "258.2" "" "" "" "" "" "" "" "" "" "" "248.0" "262.1" "237.7" "199.7" "213.2" "250.6" "310.9" "221.1" "260.2" "248.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1505271825198651647" "False" "High" "IsMasterProtein" "P41236" "Protein phosphatase inhibitor 2 OS=Homo sapiens OX=9606 GN=PPP1R2 PE=1 SV=2" "0.000" "False" "11.477" "17" "3" "5" "3" "205" "23.0" "4.74" "18.87" "3" "other metabolic processes;other biological processes" "" "enzyme regulator activity;other molecular function" "Pf04979" "5504" "ENSG00000184203" "PPP1R2" "hsa:5504; P41236" "" "" "0" "0" "1.046" "0.991" "0.991" "1.005" "0.915" "0.955" "0.982" "0.925" "0.923" "1326.0" "1387.0" "1314.5" "1313.6" "1332.3" "1212.7" "1266.7" "1302.1" "1226.5" "1223.8" "" "" "" "" "" "" "" "" "" "" "1242.4" "1147.7" "1220.4" "1015.5" "1135.7" "1158.6" "1157.5" "1156.2" "1226.5" "1178.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7848560432404461068" "False" "High" "IsMasterProtein" "Q16775" "Hydroxyacylglutathione hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HAGH PE=1 SV=2" "0.000" "False" "11.466" "13" "4" "5" "4" "308" "33.8" "8.12" "14.78" "4" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00753, Pf16123" "3029" "ENSG00000063854" "HAGH" "A8K290; B4DP33; B4DRA7; E7EN93; hsa:3029; Q16775" "" "" "0" "0" "0.930" "1.033" "1.064" "0.991" "1.117" "1.075" "0.997" "1.074" "1.098" "150.4" "139.9" "155.4" "160.0" "149.0" "168.1" "161.7" "149.9" "161.6" "165.1" "" "" "" "" "" "" "" "" "" "" "140.9" "115.7" "144.3" "123.7" "127.0" "160.6" "147.7" "133.1" "161.6" "159.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6538585977691412019" "False" "High" "IsMasterProtein" "Q9BYB4" "Guanine nucleotide-binding protein subunit beta-like protein 1 OS=Homo sapiens OX=9606 GN=GNB1L PE=1 SV=2" "0.000" "False" "11.446" "13" "3" "4" "3" "327" "35.6" "7.97" "15.80" "3" "" "" "" "Pf00400" "54584" "ENSG00000185838" "GNB1L" "hsa:54584; Q9BYB4; Q9H2S2; Q9H4M4" "22q11.2 copy number variation syndrome" "" "1" "0" "0.970" "1.039" "1.057" "1.138" "1.034" "1.102" "1.067" "0.990" "1.099" "260.7" "252.8" "270.9" "275.5" "296.8" "269.5" "287.4" "278.3" "258.2" "286.4" "" "" "" "" "" "" "" "" "" "" "244.3" "209.2" "251.5" "213.0" "253.0" "257.5" "262.6" "247.1" "258.2" "275.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6225000128541682863" "False" "High" "IsMasterProtein" "Q99836" "Myeloid differentiation primary response protein MyD88 OS=Homo sapiens OX=9606 GN=MYD88 PE=1 SV=1" "0.000" "False" "11.445" "19" "5" "6" "5" "296" "33.2" "6.15" "11.30" "5" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00531, Pf13676" "4615" "ENSG00000172936" "MYD88" "B4DKH8; B4DKU4; B4DQ60; B4DQ72; hsa:4615; J3KPU4; J3KQ87; J3KQJ6; P78397; Q53XS7; Q99836" "IL-1 signaling pathway; AGE/RAGE pathway; Interleukin-1 (IL-1) structural pathway; IL1 and megakaryocytes in obesity; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; MYD88 distinct input-output pathway; Fibrin complement receptor 3 signaling pathway; miRNA role in immune response in sepsis; LTF danger signal response pathway; Signal transduction through IL1R; Measles virus infection; Hepatitis B infection; IL-18 signaling pathway; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Induction of autophagy and toll-like receptor signaling pathways by graphene oxide ; HDAC6 interactions in the central nervous system; Toll-like receptor signaling pathway" "PIP3 activates AKT signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; ER-Phagosome pathway; Interleukin-1 signaling; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); RIP-mediated NFkB activation via ZBP1; p75NTR recruits signalling complexes; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; MyD88 cascade initiated on plasma membrane; MyD88 deficiency (TLR5); IRAK4 deficiency (TLR5); TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "35" "0" "0.872" "0.912" "0.876" "0.877" "1.002" "0.807" "0.843" "0.957" "1.003" "136.5" "119.0" "124.5" "119.6" "119.7" "136.9" "110.2" "115.1" "130.6" "136.9" "" "" "" "" "" "" "" "" "" "" "127.9" "98.5" "115.6" "92.5" "102.1" "130.8" "100.7" "102.2" "130.6" "131.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1632540778200031519" "False" "High" "IsMasterProtein" "Q9BVA0" "Katanin p80 WD40 repeat-containing subunit B1 OS=Homo sapiens OX=9606 GN=KATNB1 PE=1 SV=1" "0.000" "False" "11.442" "8" "5" "5" "5" "655" "72.3" "7.56" "14.42" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf13925" "10300" "ENSG00000140854" "KATNB1" "A6NCG6; hsa:10300; O60620; Q9BVA0" "Genes related to primary cilium development (based on CRISPR)" "" "1" "0" "0.958" "1.044" "1.134" "0.961" "1.023" "0.957" "1.044" "0.870" "0.939" "222.3" "213.0" "232.2" "252.2" "213.6" "227.5" "212.9" "232.1" "193.4" "208.8" "" "" "" "" "" "" "" "" "" "" "208.3" "176.2" "215.6" "195.0" "182.1" "217.4" "194.5" "206.1" "193.4" "201.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8597337933688242360" "False" "High" "IsMasterProtein" "P84243" "Histone H3.3 OS=Homo sapiens OX=9606 GN=H3-3B PE=1 SV=2" "0.000" "False" "11.437" "24" "4" "11" "1" "136" "15.3" "11.27" "35.80" "4" "cell organization and biogenesis;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "3020; 3021" "ENSG00000132475; ENSG00000163041" "H3-3A; H3-3B" "hsa:3020; hsa:3021; P06351; P33155; P84243; Q5VV55; Q5VV56; Q66I33; Q9V3W4" "Gastric cancer network 1; Histone modifications; Tumor suppressor activity of SMARCB1; Ciliary landscape; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; DYRK1A involvement regarding cell proliferation in brain development; 4p16.3 copy number variation; 5q35 copy number variation" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Amyloid fiber formation; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); Factors involved in megakaryocyte development and platelet production; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "36" "2" "0.952" "1.018" "0.996" "1.010" "0.977" "1.050" "0.985" "1.238" "0.960" "1202.5" "1144.9" "1224.3" "1197.1" "1214.5" "1175.0" "1262.5" "1184.6" "1489.0" "1154.4" "" "" "" "" "" "" "" "" "" "" "1126.7" "947.4" "1136.6" "925.4" "1035.2" "1122.6" "1153.6" "1051.8" "1489.0" "1111.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-823041984393634953" "False" "High" "IsMasterProtein" "P25774" "Cathepsin S OS=Homo sapiens OX=9606 GN=CTSS PE=1 SV=3" "0.000" "False" "11.436" "11" "4" "5" "4" "331" "37.5" "8.34" "16.79" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00112, Pf08246" "1520" "ENSG00000163131" "CTSS" "B4DWC9; D3DV05; hsa:1520; P25774; Q5T5I0; Q6FHS5; Q9BUG3" "" "MHC class II antigen presentation; Neutrophil degranulation; Degradation of the extracellular matrix; Assembly of collagen fibrils and other multimeric structures; Trafficking and processing of endosomal TLR; Endosomal/Vacuolar pathway" "6" "0" "0.958" "0.968" "0.930" "0.967" "1.023" "0.892" "0.988" "0.936" "0.983" "1086.3" "1041.0" "1051.8" "1010.2" "1049.9" "1111.4" "969.3" "1073.6" "1017.3" "1067.3" "" "" "" "" "" "" "" "" "" "" "1017.9" "861.4" "976.5" "780.9" "894.9" "1061.9" "885.7" "953.2" "1017.3" "1027.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2364171353668644168" "False" "High" "IsMasterProtein" "Q00653" "Nuclear factor NF-kappa-B p100 subunit OS=Homo sapiens OX=9606 GN=NFKB2 PE=1 SV=4" "0.000" "False" "11.435" "5" "5" "5" "5" "900" "96.7" "6.25" "15.72" "5" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00023, Pf00531, Pf00554, Pf16179" "4791" "ENSG00000077150" "NFKB2" "A8K9D9; D3DR83; hsa:4791; Q00653; Q04860; Q9BU75; Q9H471; Q9H472" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Thymic stromal lymphopoietin (TSLP) signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; ApoE and miR-146 in inflammation and atherosclerosis; Ebola virus infection in host; Breast cancer pathway; Acute viral myocarditis; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; FGF23 signaling in hypophosphatemic rickets and related disorders; Mitochondrial immune response to SARS-CoV-2; Neuroinflammation and glutamatergic signaling; Network map of SARS-CoV-2 signaling pathway; Inclusion body myositis; GDNF signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; Interleukin-1 processing; SUMOylation of immune response proteins; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "43" "0" "0.982" "1.018" "0.989" "1.056" "1.018" "0.980" "0.910" "1.028" "0.990" "421.5" "413.9" "429.0" "417.0" "445.2" "429.2" "413.0" "383.4" "433.5" "417.4" "" "" "" "" "" "" "" "" "" "" "395.0" "342.5" "398.3" "322.3" "379.5" "410.1" "377.3" "340.4" "433.5" "401.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2511129465997250368" "False" "High" "IsMasterProtein" "Q9NX07" "tRNA selenocysteine 1-associated protein 1 OS=Homo sapiens OX=9606 GN=TRNAU1AP PE=1 SV=1" "0.000" "False" "11.425" "11" "4" "5" "4" "287" "32.5" "4.74" "14.86" "4" "protein metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf17654" "54952" "ENSG00000180098" "TRNAU1AP" "hsa:54952; Q86SU7; Q9NX07" "Selenium metabolism and selenoproteins" "" "1" "0" "1.022" "0.953" "1.056" "0.972" "1.013" "0.961" "0.937" "0.879" "1.003" "672.1" "686.7" "640.8" "709.4" "653.0" "680.9" "646.0" "629.7" "591.0" "674.3" "" "" "" "" "" "" "" "" "" "" "629.7" "568.3" "594.9" "548.4" "556.6" "650.5" "590.2" "559.1" "591.0" "649.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7717168989126712836" "False" "High" "IsMasterProtein" "Q8TAF3" "WD repeat-containing protein 48 OS=Homo sapiens OX=9606 GN=WDR48 PE=1 SV=1" "0.000" "False" "11.416" "5" "4" "6" "4" "677" "76.2" "7.03" "17.84" "4" "DNA metabolism;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00400, Pf11816" "57599" "ENSG00000114742" "WDR48" "B4DM86; B4DQI2; B4DY84; hsa:57599; Q63HJ2; Q658Y1; Q8N3Z1; Q8TAF3; Q9NSK8; Q9P279" "DNA repair pathways, full network" "Ub-specific processing proteases; Fanconi Anemia Pathway; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins; Recognition of DNA damage by PCNA-containing replication complex" "5" "0" "1.137" "1.166" "1.036" "1.157" "1.102" "1.073" "1.081" "1.117" "1.151" "589.4" "670.0" "686.9" "610.7" "682.1" "649.6" "632.3" "636.9" "658.2" "678.1" "" "" "" "" "" "" "" "" "" "" "552.2" "554.4" "637.7" "472.1" "581.4" "620.6" "577.8" "565.5" "658.2" "652.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "967030651674579734" "False" "High" "IsMasterProtein" "Q9NV88" "Integrator complex subunit 9 OS=Homo sapiens OX=9606 GN=INTS9 PE=1 SV=2" "0.000" "False" "11.411" "5" "5" "6" "5" "658" "73.8" "6.33" "18.12" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf10996, Pf16661, Pf21382" "55756" "ENSG00000104299" "INTS9" "B7Z560; B7Z6M5; hsa:55756; O00224; Q8TB16; Q9NV88" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.047" "1.061" "1.158" "1.111" "1.060" "1.082" "1.116" "1.134" "1.115" "605.1" "633.7" "642.2" "700.5" "672.1" "641.7" "654.9" "675.4" "686.2" "674.8" "" "" "" "" "" "" "" "" "" "" "567.0" "524.4" "596.2" "541.5" "572.9" "613.1" "598.4" "599.6" "686.2" "649.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518403686067478951" "False" "High" "IsMasterProtein" "O95149" "Snurportin-1 OS=Homo sapiens OX=9606 GN=SNUPN PE=1 SV=1" "0.000" "False" "11.401" "10" "4" "7" "4" "360" "41.1" "6.64" "21.82" "4" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11538" "10073" "ENSG00000169371" "SNUPN" "A6NE34; A8K0B0; D3DW76; hsa:10073; O95149" "" "snRNP Assembly" "1" "0" "0.995" "0.980" "1.040" "1.048" "1.031" "0.960" "0.988" "1.040" "0.997" "565.2" "562.3" "554.1" "587.9" "592.5" "582.7" "542.4" "558.4" "588.1" "563.6" "" "" "" "" "" "" "" "" "" "" "529.6" "465.3" "514.4" "454.5" "505.0" "556.7" "495.6" "495.8" "588.1" "542.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6374027858147592096" "False" "High" "IsMasterProtein" "O95613" "Pericentrin OS=Homo sapiens OX=9606 GN=PCNT PE=1 SV=4" "0.000" "False" "11.398" "1" "5" "5" "5" "3336" "377.8" "5.55" "12.69" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton" "other molecular function" "Pf10495" "5116" "ENSG00000160299" "PCNT" "hsa:5116; O43152; O95613; Q7Z7C9" "" "Late endosomal microautophagy; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Chaperone Mediated Autophagy" "10" "0" "1.112" "1.103" "1.087" "1.102" "1.121" "1.231" "1.106" "1.152" "1.165" "116.9" "130.0" "129.0" "127.1" "128.8" "131.0" "143.9" "129.3" "134.7" "136.2" "" "" "" "" "" "" "" "" "" "" "109.6" "107.6" "119.8" "98.3" "109.8" "125.2" "131.5" "114.8" "134.7" "131.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9196998486354008360" "False" "High" "IsMasterProtein" "Q6F5E8" "Capping protein, Arp2/3 and myosin-I linker protein 2 OS=Homo sapiens OX=9606 GN=CARMIL2 PE=1 SV=2" "0.000" "False" "11.393" "3" "4" "4" "4" "1435" "154.6" "6.76" "12.21" "4" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13516, Pf16000, Pf17888" "146206" "ENSG00000159753" "CARMIL2" "B8X2Z3; hsa:146206; Q6F5E8" "" "" "0" "0" "0.988" "1.029" "1.150" "1.059" "0.978" "1.023" "0.973" "0.967" "1.058" "188.5" "186.2" "194.1" "216.7" "199.6" "184.3" "192.9" "183.4" "182.2" "199.4" "" "" "" "" "" "" "" "" "" "" "176.6" "154.1" "180.2" "167.6" "170.2" "176.1" "176.2" "162.9" "182.2" "191.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4255183124898333384" "False" "High" "IsMasterProtein" "Q9Y6G5" "COMM domain-containing protein 10 OS=Homo sapiens OX=9606 GN=COMMD10 PE=1 SV=1" "0.000" "False" "11.383" "20" "4" "4" "4" "202" "23.0" "6.54" "12.89" "4" "" "nucleus;other cell component" "" "Pf07258, Pf21672" "51397" "ENSG00000145781" "COMMD10" "D3DT07; hsa:51397; Q9P077; Q9Y6G5" "" "Neddylation" "1" "0" "0.973" "1.072" "1.092" "1.142" "1.096" "1.040" "1.075" "1.080" "1.087" "609.7" "593.0" "653.6" "665.7" "696.0" "668.0" "634.1" "655.4" "658.2" "662.7" "" "" "" "" "" "" "" "" "" "" "571.3" "490.7" "606.7" "514.6" "593.3" "638.2" "579.4" "581.9" "658.2" "638.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1107540500627023376" "False" "High" "IsMasterProtein" "Q96EE3" "Nucleoporin SEH1 OS=Homo sapiens OX=9606 GN=SEH1L PE=1 SV=3" "0.000" "False" "11.383" "10" "4" "4" "4" "360" "39.6" "8.09" "12.86" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "81929" "ENSG00000085415" "SEH1L" "A8K5B1; hsa:81929; Q8NFU6; Q96EE3; Q96MH3; Q9C069" "" "Amino acids regulate mTORC1" "1" "0" "1.064" "1.065" "1.016" "1.007" "0.990" "1.031" "0.999" "1.068" "1.055" "691.0" "734.9" "735.6" "702.3" "696.0" "683.9" "712.5" "690.2" "737.9" "728.7" "" "" "" "" "" "" "" "" "" "" "647.4" "608.1" "683.0" "542.9" "593.3" "653.4" "651.1" "612.8" "737.9" "701.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5757828644476711483" "False" "High" "IsMasterProtein" "Q9NXR1" "Nuclear distribution protein nudE homolog 1 OS=Homo sapiens OX=9606 GN=NDE1 PE=1 SV=3" "0.000" "False" "11.378" "13" "5" "5" "5" "335" "37.7" "5.15" "15.67" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04880" "54820" "ENSG00000072864; ENSG00000275911" "NDE1" "hsa:54820; Q49AQ2; Q9NXR1" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "13" "0" "1.081" "1.041" "1.052" "1.056" "1.109" "1.028" "1.047" "1.035" "1.018" "821.0" "887.6" "854.7" "863.6" "867.2" "910.1" "843.8" "859.5" "849.4" "835.6" "" "" "" "" "" "" "" "" "" "" "769.2" "734.5" "793.5" "667.6" "739.2" "869.5" "771.0" "763.1" "849.4" "804.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3782870004774892945" "False" "High" "IsMasterProtein" "Q15796" "Mothers against decapentaplegic homolog 2 OS=Homo sapiens OX=9606 GN=SMAD2 PE=1 SV=1" "0.000" "False" "11.367" "7" "3" "6" "3" "467" "52.3" "6.58" "16.86" "3" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4087" "ENSG00000175387" "SMAD2" "hsa:4087; Q15796" "Cell cycle; AGE/RAGE pathway; Endoderm differentiation; Mesodermal commitment pathway; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Tgif disruption of Shh signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Neovascularization processes; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Hepatitis B infection; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Overlap between signal transduction pathways contributing to LMNA laminopathies; LDLRAD4 and what we know about it; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Progeria-associated lipodystrophy; Th17 cell differentiation pathway; GDNF signaling; Inflammatory bowel disease signaling; Macrophage-stimulating protein (MSP) signaling network map; HDAC6 interactions in the central nervous system; TGF-beta receptor signaling" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Ub-specific processing proteases; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Formation of axial mesoderm; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Germ layer formation at gastrulation; Formation of definitive endoderm; Transcriptional regulation of pluripotent stem cells; Signaling by Activin; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer" "49" "0" "1.179" "1.171" "1.182" "1.058" "1.089" "1.049" "0.990" "0.967" "1.023" "344.7" "406.3" "403.6" "407.6" "364.8" "375.3" "361.6" "341.4" "333.3" "352.8" "" "" "" "" "" "" "" "" "" "" "323.0" "336.2" "374.7" "315.1" "311.0" "358.5" "330.4" "303.1" "333.3" "339.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4153058016593714536" "False" "High" "IsMasterProtein" "Q9UKT5" "F-box only protein 4 OS=Homo sapiens OX=9606 GN=FBXO4 PE=1 SV=2" "0.000" "False" "11.361" "8" "3" "5" "3" "387" "44.1" "6.16" "15.94" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00646" "26272" "ENSG00000151876" "FBXO4" "hsa:26272; Q68CU8; Q86VT8; Q9UK98; Q9UKT5" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "3" "0" "1.082" "1.125" "1.118" "1.110" "1.056" "1.096" "0.991" "0.987" "1.069" "522.9" "565.9" "588.3" "584.5" "580.4" "552.2" "573.2" "518.1" "516.3" "559.1" "" "" "" "" "" "" "" "" "" "" "490.0" "468.3" "546.2" "451.8" "494.7" "527.6" "523.8" "460.0" "516.3" "538.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3981569091438122921" "False" "High" "IsMasterProtein" "Q8N4P3" "Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 OS=Homo sapiens OX=9606 GN=HDDC3 PE=1 SV=3" "0.000" "False" "11.353" "22" "3" "3" "3" "179" "20.3" "6.74" "12.07" "3" "" "" "other molecular function" "Pf13328" "374659" "ENSG00000184508" "HDDC3" "hsa:374659; Q8N4P3" "" "" "0" "0" "0.898" "0.843" "0.964" "0.967" "1.036" "0.874" "0.902" "0.942" "0.954" "675.4" "606.2" "569.3" "651.3" "652.9" "699.9" "590.1" "609.2" "636.1" "644.1" "" "" "" "" "" "" "" "" "" "" "632.8" "501.6" "528.6" "503.5" "556.5" "668.7" "539.2" "540.9" "636.1" "620.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2189379826665428433" "False" "High" "IsMasterProtein" "Q9UMY1" "U3 small nucleolar RNA-associated protein NOL7 OS=Homo sapiens OX=9606 GN=NOL7 PE=1 SV=2" "0.000" "False" "11.352" "13" "4" "4" "4" "257" "29.4" "9.67" "12.11" "4" "other biological processes" "mitochondrion;nucleus;other cell component" "" "Pf08157" "51406" "ENSG00000225921" "NOL7" "hsa:51406; Q5T297; Q9UMY1; Q9Y3U7" "" "" "0" "0" "1.033" "0.995" "0.970" "1.076" "1.019" "1.276" "1.277" "1.236" "1.038" "663.6" "685.7" "660.5" "643.9" "713.9" "676.3" "847.0" "847.5" "820.4" "688.9" "" "" "" "" "" "" "" "" "" "" "621.7" "567.4" "613.2" "497.8" "608.5" "646.2" "773.9" "752.5" "820.4" "663.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4493401864324206702" "False" "High" "IsMasterProtein" "Q53S33" "BolA-like protein 3 OS=Homo sapiens OX=9606 GN=BOLA3 PE=1 SV=1" "0.000" "False" "11.351" "39" "4" "6" "4" "107" "12.1" "9.64" "20.94" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "" "Pf01722" "388962" "ENSG00000163170" "BOLA3" "G3XAB0; hsa:388962; Q53S33" "" "" "0" "0" "0.969" "0.965" "0.978" "1.048" "1.004" "0.991" "0.941" "0.873" "1.026" "1357.4" "1315.9" "1310.1" "1327.7" "1422.8" "1362.8" "1345.6" "1276.7" "1184.4" "1393.2" "" "" "" "" "" "" "" "" "" "" "1271.9" "1088.9" "1216.3" "1026.4" "1212.8" "1302.0" "1229.5" "1133.6" "1184.4" "1341.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4026716302863274085" "False" "High" "IsMasterProtein" "Q5T5X7" "BEN domain-containing protein 3 OS=Homo sapiens OX=9606 GN=BEND3 PE=1 SV=1" "0.000" "False" "11.347" "5" "4" "4" "4" "828" "94.4" "5.43" "12.53" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf10523" "57673" "ENSG00000178409" "BEND3" "A2RRH2; hsa:57673; Q5T5X7; Q9HCL9" "" "" "0" "0" "1.031" "1.033" "0.946" "0.980" "1.017" "0.835" "0.804" "0.912" "0.939" "259.0" "267.2" "267.5" "245.0" "253.9" "263.4" "216.3" "208.2" "236.1" "243.3" "" "" "" "" "" "" "" "" "" "" "242.7" "221.1" "248.3" "189.4" "216.4" "251.6" "197.7" "184.9" "236.1" "234.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5113146668834443448" "False" "High" "IsMasterProtein" "Q9NRG4" "N-lysine methyltransferase SMYD2 OS=Homo sapiens OX=9606 GN=SMYD2 PE=1 SV=2" "0.000" "False" "11.340" "9" "5" "6" "5" "433" "49.7" "6.71" "16.15" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00856, Pf01753" "56950" "ENSG00000143499" "SMYD2" "B2R9P9; hsa:56950; I6L9H7; Q4V765; Q5VSH9; Q96AI4; Q9NRG4" "Histone modifications" "PKMTs methylate histone lysines; Regulation of TP53 Activity through Methylation" "3" "0" "0.939" "0.963" "0.894" "0.913" "0.970" "0.826" "0.878" "0.904" "0.939" "321.6" "302.0" "309.8" "287.6" "293.5" "311.8" "265.8" "282.2" "290.7" "301.8" "" "" "" "" "" "" "" "" "" "" "301.3" "249.9" "287.6" "222.3" "250.2" "297.9" "242.8" "250.6" "290.7" "290.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-519156847082484659" "False" "High" "IsMasterProtein" "Q16695" "Histone H3.1t OS=Homo sapiens OX=9606 GN=H3-4 PE=1 SV=3" "0.000" "False" "11.333" "24" "4" "9" "1" "136" "15.5" "11.12" "29.13" "4" "cell organization and biogenesis" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "8290" "ENSG00000168148; ENSG00000285435" "H3-4" "B2R5K3; hsa:8290; Q16695; Q6FGU4" "Follicle stimulating hormone (FSH) signaling pathway; Male infertility" "Meiotic synapsis; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Formation of the beta-catenin:TCF transactivating complex; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ)" "17" "0" "0.994" "1.091" "1.078" "1.011" "1.045" "1.098" "0.947" "0.982" "1.005" "340.2" "338.1" "371.1" "366.8" "344.1" "355.6" "373.4" "322.3" "334.2" "341.8" "" "" "" "" "" "" "" "" "" "" "318.8" "279.8" "344.5" "283.6" "293.3" "339.8" "341.2" "286.2" "334.2" "329.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1189012646270467424" "False" "High" "IsMasterProtein" "Q9H5Q4" "Dimethyladenosine transferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TFB2M PE=1 SV=1" "0.000" "False" "11.330" "11" "5" "6" "5" "396" "45.3" "9.19" "17.98" "5" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00398" "64216" "ENSG00000162851" "TFB2M" "hsa:64216; Q9H5Q4; Q9H626" "Energy metabolism; Mitochondrial gene expression" "Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis" "4" "0" "0.991" "1.079" "1.036" "0.974" "0.997" "0.998" "1.036" "0.979" "1.012" "879.8" "871.8" "949.5" "911.3" "856.7" "876.7" "878.3" "911.1" "861.5" "890.2" "" "" "" "" "" "" "" "" "" "" "824.4" "721.4" "881.5" "704.4" "730.3" "837.6" "802.6" "809.0" "861.5" "857.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6108137657648573585" "False" "High" "IsMasterProtein" "O95571" "Persulfide dioxygenase ETHE1, mitochondrial OS=Homo sapiens OX=9606 GN=ETHE1 PE=1 SV=2" "0.000" "False" "11.314" "13" "3" "5" "3" "254" "27.9" "6.83" "18.12" "3" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00753" "23474" "ENSG00000105755" "ETHE1" "hsa:23474; O95571; Q96HR0; Q9H001" "" "Sulfide oxidation to sulfate" "1" "0" "1.052" "1.076" "1.136" "1.161" "1.104" "1.118" "1.045" "1.123" "1.188" "192.1" "202.1" "206.7" "218.2" "223.1" "212.1" "214.8" "200.8" "215.7" "228.3" "" "" "" "" "" "" "" "" "" "" "180.0" "167.2" "191.9" "168.7" "190.1" "202.6" "196.2" "178.3" "215.7" "219.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1581896134396951467" "False" "High" "IsMasterProtein" "P49006" "MARCKS-related protein OS=Homo sapiens OX=9606 GN=MARCKSL1 PE=1 SV=2" "0.000" "False" "11.294" "18" "3" "5" "3" "195" "19.5" "4.67" "13.21" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02063" "65108" "ENSG00000175130" "MARCKSL1" "D3DPQ0; hsa:65108; P49006; Q5TEE6; Q6NXS5" "" "" "0" "0" "1.030" "0.819" "1.041" "0.862" "0.739" "2.040" "0.901" "0.819" "1.091" "65.9" "67.9" "54.0" "68.7" "56.8" "48.7" "134.5" "59.4" "54.0" "71.9" "" "" "" "" "" "" "" "" "" "" "61.8" "56.2" "50.1" "53.1" "48.4" "46.5" "122.9" "52.8" "54.0" "69.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7874915043186486884" "False" "High" "IsMasterProtein" "P20962" "Parathymosin OS=Homo sapiens OX=9606 GN=PTMS PE=1 SV=2" "0.000" "False" "11.285" "22" "2" "3" "2" "102" "11.5" "4.16" "11.52" "2" "DNA metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf03247" "5763" "ENSG00000159335" "PTMS" "hsa:5763; P20962" "IL-18 signaling pathway" "" "1" "0" "0.872" "0.969" "0.941" "1.014" "0.930" "0.978" "0.884" "0.989" "0.994" "444.6" "387.6" "430.8" "418.2" "450.7" "413.5" "434.8" "392.9" "439.6" "441.7" "" "" "" "" "" "" "" "" "" "" "416.5" "320.7" "399.9" "323.3" "384.2" "395.0" "397.3" "348.9" "439.6" "425.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5723466212240730486" "False" "High" "IsMasterProtein" "Q13574" "Diacylglycerol kinase zeta OS=Homo sapiens OX=9606 GN=DGKZ PE=1 SV=4" "0.000" "False" "11.285" "5" "4" "4" "4" "928" "103.9" "8.05" "10.18" "4" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00023, Pf00130, Pf00609, Pf00781" "8525" "ENSG00000149091" "DGKZ" "B7Z2M9; B7Z6M3; E9PPW4; F6UCU9; G3V0F6; hsa:8525; J3KNJ6; O00542; Q13574; Q6ZVG7; Q8IVW9" "Myometrial relaxation and contraction pathways; Leptin-insulin signaling overlap; Glycerolipids and glycerophospholipids; Modulators of TCR signaling and T cell activation" "Effects of PIP2 hydrolysis" "5" "0" "1.070" "0.943" "1.102" "0.944" "0.930" "1.003" "0.915" "0.931" "0.987" "342.8" "366.9" "323.3" "377.6" "323.7" "318.9" "343.8" "313.7" "319.1" "338.5" "" "" "" "" "" "" "" "" "" "" "321.2" "303.6" "300.2" "291.9" "275.9" "304.7" "314.2" "278.6" "319.1" "325.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1630996109560083637" "False" "High" "IsMasterProtein" "O75909" "Cyclin-K OS=Homo sapiens OX=9606 GN=CCNK PE=1 SV=2" "0.000" "False" "11.283" "9" "4" "5" "4" "580" "64.2" "8.41" "17.24" "4" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00134, Pf21797" "8812" "ENSG00000090061" "CCNK" "hsa:8812; O75909; Q59FT6; Q86U16; Q96B63; Q9NNY9" "Male infertility" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes" "10" "0" "0.915" "1.017" "1.005" "0.999" "0.995" "0.985" "1.056" "1.029" "1.043" "646.7" "591.4" "657.6" "650.1" "645.8" "643.7" "636.9" "683.2" "665.7" "674.6" "" "" "" "" "" "" "" "" "" "" "605.9" "489.4" "610.5" "502.5" "550.5" "615.0" "581.9" "606.6" "665.7" "649.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2632668230264232030" "False" "High" "IsMasterProtein" "P61024" "Cyclin-dependent kinases regulatory subunit 1 OS=Homo sapiens OX=9606 GN=CKS1B PE=1 SV=1" "0.000" "False" "11.277" "28" "4" "5" "3" "79" "9.7" "8.94" "14.02" "4" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01111" "1163" "ENSG00000173207" "CKS1B" "hsa:1163; P33551; P61024" "Small cell lung cancer" "SCF(Skp2)-mediated degradation of p27/p21; Cyclin D associated events in G1" "3" "0" "1.259" "1.118" "0.971" "1.023" "0.875" "0.850" "0.989" "1.031" "1.023" "628.8" "791.5" "702.7" "610.5" "643.0" "550.0" "534.5" "622.1" "648.6" "643.1" "" "" "" "" "" "" "" "" "" "" "589.2" "655.0" "652.4" "471.9" "548.1" "525.5" "488.4" "552.4" "648.6" "619.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2612054938348296953" "False" "High" "IsMasterProtein" "Q16595" "Frataxin, mitochondrial OS=Homo sapiens OX=9606 GN=FXN PE=1 SV=2" "0.000" "False" "11.277" "22" "4" "6" "4" "210" "23.1" "8.69" "8.36" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf01491" "2395" "ENSG00000165060" "FXN" "A8MXJ6; C9JJ89; hsa:2395; O15545; O95656; Q15294; Q16595; Q5VZ01" "Iron-sulfur cluster biogenesis" "Mitochondrial protein import; Mitochondrial iron-sulfur cluster biogenesis" "3" "0" "0.960" "1.114" "0.962" "0.993" "0.958" "0.985" "0.944" "0.932" "0.992" "265.4" "254.7" "295.6" "255.3" "263.4" "254.1" "261.4" "250.5" "247.4" "263.4" "" "" "" "" "" "" "" "" "" "" "248.7" "210.8" "274.4" "197.4" "224.5" "242.8" "238.8" "222.4" "247.4" "253.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6653368877228174187" "False" "High" "IsMasterProtein" "Q9NRX2" "Large ribosomal subunit protein bL17m OS=Homo sapiens OX=9606 GN=MRPL17 PE=1 SV=1" "0.000" "False" "11.266" "24" "5" "5" "5" "175" "20.0" "10.11" "11.11" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01196" "63875" "ENSG00000158042" "MRPL17" "D3DQU3; hsa:63875; Q6IAH8; Q96Q53; Q9C066; Q9NRX2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.874" "1.165" "0.965" "1.055" "1.286" "1.038" "1.074" "1.118" "1.056" "136.3" "119.2" "158.8" "131.6" "143.9" "175.3" "141.5" "146.4" "152.5" "144.0" "" "" "" "" "" "" "" "" "" "" "127.7" "98.6" "147.4" "101.7" "122.6" "167.5" "129.3" "130.0" "152.5" "138.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6002739480164065296" "False" "High" "IsMasterProtein" "Q14137" "Ribosome biogenesis protein BOP1 OS=Homo sapiens OX=9606 GN=BOP1 PE=1 SV=2" "0.000" "False" "11.247" "5" "4" "8" "4" "746" "83.6" "6.19" "22.09" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf08145" "23246" "ENSG00000261236" "BOP1" "hsa:23246; Q14137; Q969Z6; Q96IS8; Q96Q25; Q9BSA7; Q9BVM0" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.015" "1.081" "1.206" "1.161" "1.112" "1.050" "1.029" "0.981" "1.074" "419.4" "425.8" "453.2" "505.9" "487.0" "466.2" "440.3" "431.4" "411.3" "450.3" "" "" "" "" "" "" "" "" "" "" "392.9" "352.3" "420.8" "391.1" "415.1" "445.4" "402.3" "383.0" "411.3" "433.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3661455698439909776" "False" "High" "IsMasterProtein" "Q96AG4" "Leucine-rich repeat-containing protein 59 OS=Homo sapiens OX=9606 GN=LRRC59 PE=1 SV=1" "0.000" "False" "11.239" "11" "4" "4" "4" "307" "34.9" "9.57" "11.14" "4" "signal transduction" "other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "" "Pf13855" "55379" "ENSG00000108829" "LRRC59" "B2RE83; D3DTX8; hsa:55379; Q96AG4; Q9P189" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.901" "0.977" "1.182" "1.104" "1.088" "0.977" "0.960" "0.995" "1.089" "123.8" "111.5" "120.9" "146.3" "136.6" "134.6" "120.9" "118.8" "123.2" "134.8" "" "" "" "" "" "" "" "" "" "" "116.0" "92.3" "112.2" "113.1" "116.4" "128.6" "110.5" "105.5" "123.2" "129.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2596521025155403540" "False" "High" "IsMasterProtein" "Q9BXM9" "FSD1-like protein OS=Homo sapiens OX=9606 GN=FSD1L PE=1 SV=2" "0.000" "False" "11.226" "8" "4" "4" "4" "530" "59.5" "6.20" "6.15" "4" "" "" "" "Pf00622" "83856" "ENSG00000106701" "FSD1L" "A2A338; A6NKH7; B7Z5S6; B7Z5W3; hsa:83856; Q5T879; Q5T880; Q9BXM9" "" "" "0" "0" "0.986" "1.009" "1.044" "0.947" "1.002" "0.914" "0.936" "0.987" "1.006" "446.9" "440.7" "450.9" "466.7" "423.2" "447.6" "408.6" "418.1" "441.3" "449.6" "" "" "" "" "" "" "" "" "" "" "418.8" "364.7" "418.6" "360.8" "360.7" "427.6" "373.3" "371.2" "441.3" "432.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4937271554403891889" "False" "High" "IsMasterProtein" "P16150" "Leukosialin OS=Homo sapiens OX=9606 GN=SPN PE=1 SV=1" "0.000" "False" "11.225" "15" "4" "4" "4" "400" "40.3" "5.10" "14.93" "4" "cell adhesion;cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "" "6693" "ENSG00000197471" "SPN" "A8K9B1; hsa:6693; P16150" "16p11.2 proximal deletion syndrome" "Basigin interactions" "3" "0" "1.041" "1.019" "1.044" "1.036" "1.034" "1.039" "1.073" "0.985" "1.017" "1064.1" "1107.3" "1083.9" "1111.2" "1102.9" "1100.3" "1106.1" "1141.5" "1048.1" "1081.8" "" "" "" "" "" "" "" "" "" "" "997.1" "916.3" "1006.3" "859.0" "940.1" "1051.2" "1010.7" "1013.5" "1048.1" "1041.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6667774858643488951" "False" "High" "IsMasterProtein" "P11308" "Transcriptional regulator ERG OS=Homo sapiens OX=9606 GN=ERG PE=1 SV=3" "0.000" "False" "11.224" "10" "4" "7" "3" "479" "53.8" "7.65" "13.99" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198" "2078" "ENSG00000157554" "ERG" "B4DTW5; B4E0T4; hsa:2078; P11308; Q16113; Q6XXX4; Q6XXX5; Q8IXK9" "Genes targeted by miRNAs in adipocytes; Androgen receptor network in prostate cancer; VEGFA-VEGFR2 signaling; HDAC6 interactions in the central nervous system" "" "4" "0" "1.012" "0.992" "0.942" "1.028" "1.031" "0.936" "0.929" "0.935" "1.031" "317.8" "321.7" "315.1" "299.3" "326.6" "327.6" "297.6" "295.3" "297.1" "327.5" "" "" "" "" "" "" "" "" "" "" "297.8" "266.2" "292.6" "231.4" "278.4" "313.0" "271.9" "262.2" "297.1" "315.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1385876623079047354" "False" "High" "IsMasterProtein" "Q9UFC0" "Leucine-rich repeat and WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=LRWD1 PE=1 SV=2" "0.000" "False" "11.221" "6" "4" "5" "4" "647" "70.8" "7.21" "15.67" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf00560" "222229" "ENSG00000161036" "LRWD1" "A8K4K2; B2R9G2; hsa:222229; Q8N0T9; Q8WV43; Q96GJ2; Q9UFC0" "Male infertility" "" "1" "0" "1.037" "0.962" "1.070" "1.056" "1.003" "0.996" "0.993" "0.897" "1.009" "817.8" "848.4" "787.0" "875.0" "863.9" "820.6" "814.3" "811.7" "733.4" "825.2" "" "" "" "" "" "" "" "" "" "" "766.3" "702.0" "730.6" "676.4" "736.4" "784.0" "744.1" "720.7" "733.4" "794.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-334461821702611292" "False" "High" "IsMasterProtein" "Q6DCA0" "AMMECR1-like protein OS=Homo sapiens OX=9606 GN=AMMECR1L PE=1 SV=1" "0.000" "False" "11.219" "11" "4" "4" "1" "310" "34.5" "8.98" "13.30" "4" "" "nucleus" "" "Pf01871" "83607" "ENSG00000144233" "AMMECR1L" "B4E276; hsa:83607; Q6DCA0" "" "" "0" "2" "1.141" "1.032" "0.971" "1.035" "1.148" "0.966" "0.978" "1.114" "1.029" "464.9" "530.7" "479.9" "451.4" "481.1" "533.7" "449.2" "454.7" "517.8" "478.6" "" "" "" "" "" "" "" "" "" "" "435.6" "439.2" "445.5" "349.0" "410.1" "509.9" "410.4" "403.7" "517.8" "460.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3838187860165332500" "False" "High" "IsMasterProtein" "P52564" "Dual specificity mitogen-activated protein kinase kinase 6 OS=Homo sapiens OX=9606 GN=MAP2K6 PE=1 SV=1" "0.000" "False" "11.207" "12" "4" "4" "2" "334" "37.5" "7.39" "12.73" "4" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5608" "ENSG00000108984" "MAP2K6" "hsa:5608; P52564" "MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Photodynamic therapy-induced AP-1 survival signaling; TGF-beta signaling pathway; MAPK signaling pathway; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; p38 MAPK signaling pathway; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; 16p11.2 proximal deletion syndrome; Angiotensin II receptor type 1 pathway; Pleural mesothelioma; GNAQ pathways in port-wine stain; Interferon type I signaling pathways; Serotonin HTR1 group and FOS pathway; Toll-like receptor signaling pathway" "PKR-mediated signaling; Myogenesis; NOD1/2 Signaling Pathway; Interleukin-1 signaling; Oxidative Stress Induced Senescence; activated TAK1 mediates p38 MAPK activation; PI5P Regulates TP53 Acetylation" "41" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7599147423310777868" "False" "High" "IsMasterProtein" "P55199" "RNA polymerase II elongation factor ELL OS=Homo sapiens OX=9606 GN=ELL PE=1 SV=1" "0.000" "False" "11.200" "6" "4" "4" "4" "621" "68.2" "9.33" "12.84" "4" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07303, Pf10390" "8178" "ENSG00000105656" "ELL" "hsa:8178; P55199" "Interactome of polycomb repressive complex 2 (PRC2)" "TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; Transcription-Coupled Nucleotide Excision Repair (TC-NER)" "14" "0" "1.035" "1.088" "1.114" "1.043" "1.032" "1.036" "1.040" "1.136" "1.046" "403.0" "417.3" "438.3" "449.0" "420.4" "416.0" "417.4" "419.2" "457.9" "421.4" "" "" "" "" "" "" "" "" "" "" "377.6" "345.3" "406.9" "347.1" "358.3" "397.4" "381.4" "372.2" "457.9" "405.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3629092038123866655" "False" "High" "IsMasterProtein" "Q86TP1" "Exopolyphosphatase PRUNE1 OS=Homo sapiens OX=9606 GN=PRUNE1 PE=1 SV=2" "0.000" "False" "11.188" "11" "4" "4" "4" "453" "50.2" "5.50" "12.93" "4" "other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01368, Pf02833" "58497" "ENSG00000143363" "PRUNE1" "B2RCH8; B4DFL7; Q5SZF9; Q659E5; Q6P4E0; Q86TP1; Q8N654; Q96JU5; Q9C071; Q9C072; Q9UIV0" "" "" "0" "0" "1.038" "1.030" "1.075" "1.052" "0.977" "1.095" "0.915" "1.022" "1.050" "345.7" "358.9" "356.0" "371.8" "363.6" "337.7" "378.5" "316.4" "353.2" "363.2" "" "" "" "" "" "" "" "" "" "" "323.9" "297.0" "330.5" "287.4" "309.9" "322.7" "345.8" "280.9" "353.2" "349.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4890653308716064100" "False" "High" "IsMasterProtein" "Q9H981" "Actin-related protein 8 OS=Homo sapiens OX=9606 GN=ACTR8 PE=1 SV=2" "0.000" "False" "11.188" "7" "5" "6" "5" "624" "70.4" "7.78" "15.50" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus" "other molecular function" "Pf00022" "93973" "ENSG00000113812" "ACTR8" "B3KSW7; hsa:93973; Q8N566; Q9H663; Q9H981" "" "UCH proteinases; DNA Damage Recognition in GG-NER" "2" "0" "1.251" "0.893" "1.231" "2.212" "1.033" "0.961" "0.954" "1.122" "1.063" "40.0" "50.0" "35.7" "49.2" "88.4" "41.3" "38.4" "38.1" "44.9" "42.5" "" "" "" "" "" "" "" "" "" "" "37.5" "41.4" "33.1" "38.1" "75.4" "39.5" "35.1" "33.9" "44.9" "40.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7525494529212049263" "False" "High" "IsMasterProtein" "O43149" "Zinc finger ZZ-type and EF-hand domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZZEF1 PE=1 SV=6" "0.000" "False" "11.185" "2" "5" "6" "5" "2961" "330.9" "5.95" "15.90" "5" "cell organization and biogenesis" "" "other molecular function" "Pf00569, Pf03256" "23140" "ENSG00000074755" "ZZEF1" "A7MBM5; hsa:23140; O43149; Q6NXG0; Q6ZRA1; Q6ZSF4; Q9NVB9" "" "" "0" "0" "0.951" "1.008" "0.950" "0.995" "1.016" "0.989" "0.931" "0.933" "0.998" "709.2" "674.6" "715.2" "674.0" "705.8" "720.5" "701.2" "660.6" "661.9" "707.7" "" "" "" "" "" "" "" "" "" "" "664.6" "558.2" "664.0" "521.0" "601.6" "688.3" "640.7" "586.5" "661.9" "681.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8641441660686703988" "False" "High" "IsMasterProtein" "O94868" "F-BAR and double SH3 domains protein 2 OS=Homo sapiens OX=9606 GN=FCHSD2 PE=1 SV=3" "0.000" "False" "11.179" "5" "5" "6" "5" "740" "84.2" "5.77" "15.71" "5" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00611, Pf14604" "9873" "ENSG00000137478" "FCHSD2" "B4DNI3; hsa:9873; O94868; Q7L8J9; Q8WVM2; Q96FV7; Q9UF77" "" "" "0" "0" "1.029" "1.034" "0.925" "1.079" "1.089" "0.931" "1.036" "1.047" "1.058" "445.2" "458.0" "460.6" "411.7" "480.5" "485.0" "414.4" "461.3" "466.1" "471.1" "" "" "" "" "" "" "" "" "" "" "417.2" "379.0" "427.6" "318.3" "409.5" "463.4" "378.6" "409.6" "466.1" "453.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8911180821409162451" "False" "High" "IsMasterProtein" "Q9NYB9" "Abl interactor 2 OS=Homo sapiens OX=9606 GN=ABI2 PE=1 SV=1" "0.000" "False" "11.176" "7" "4" "6" "2" "513" "55.6" "6.16" "20.17" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00018, Pf07815" "10152" "ENSG00000138443" "ABI2" "B4DSN1; hsa:10152; Q13147; Q13249; Q13801; Q9BV70; Q9NYB9" "Regulation of actin cytoskeleton" "RAC1 GTPase cycle; RAC2 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "8" "0" "1.136" "0.990" "1.018" "1.047" "0.929" "0.975" "0.976" "0.918" "0.995" "171.7" "195.1" "170.1" "174.9" "179.7" "159.6" "167.4" "167.7" "157.6" "170.9" "" "" "" "" "" "" "" "" "" "" "160.9" "161.4" "157.9" "135.2" "153.2" "152.5" "153.0" "148.9" "157.6" "164.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6449496976955696731" "False" "High" "IsMasterProtein" "Q9UHR5" "SAP30-binding protein OS=Homo sapiens OX=9606 GN=SAP30BP PE=1 SV=1" "0.000" "False" "11.167" "12" "4" "5" "4" "308" "33.9" "4.84" "18.30" "4" "other biological processes" "cytoskeleton;nucleus" "" "Pf07818" "29115" "ENSG00000161526" "SAP30BP" "B3KML7; hsa:29115; Q8N1R5; Q8TDR8; Q96D27; Q9UHR5" "" "NoRC negatively regulates rRNA expression" "1" "0" "1.014" "0.983" "0.955" "1.035" "1.023" "0.996" "1.043" "1.015" "1.004" "870.6" "882.6" "856.2" "831.8" "901.1" "890.6" "867.3" "908.1" "884.0" "874.5" "" "" "" "" "" "" "" "" "" "" "815.8" "730.3" "794.9" "643.1" "768.0" "850.8" "792.5" "806.3" "884.0" "842.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3972038562420252503" "False" "High" "IsMasterProtein" "P61254" "Large ribosomal subunit protein uL24 OS=Homo sapiens OX=9606 GN=RPL26 PE=1 SV=1" "0.000" "False" "11.151" "23" "5" "6" "5" "145" "17.2" "10.55" "18.28" "5" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00467, Pf16906" "6154" "ENSG00000161970" "RPL26" "B2R4F0; D3DTR8; hsa:6154; P61254; Q02877; Q6IPY2" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.032" "1.009" "1.036" "1.087" "1.087" "1.107" "1.104" "1.013" "1.080" "1150.8" "1187.3" "1161.0" "1191.7" "1251.1" "1250.9" "1273.9" "1270.6" "1165.9" "1243.4" "" "" "" "" "" "" "" "" "" "" "1078.3" "982.5" "1077.9" "921.2" "1066.4" "1195.1" "1164.0" "1128.1" "1165.9" "1197.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1871023154594230453" "False" "High" "IsMasterProtein" "Q14241" "Elongin-A OS=Homo sapiens OX=9606 GN=ELOA PE=1 SV=3" "0.000" "False" "11.150" "5" "5" "6" "5" "772" "87.2" "9.57" "15.49" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf06881, Pf08711" "6924" "ENSG00000011007" "ELOA" "B2R7Q8; hsa:6924; Q14241; Q8IXH1" "VEGFA-VEGFR2 signaling; MET in type 1 papillary renal cell carcinoma; 10q11.21q11.23 copy number variation syndrome" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "14" "0" "1.017" "0.972" "1.152" "1.169" "1.109" "1.337" "1.341" "1.243" "1.156" "1064.8" "1082.7" "1035.0" "1226.3" "1244.8" "1180.8" "1423.6" "1427.9" "1323.6" "1230.5" "" "" "" "" "" "" "" "" "" "" "997.7" "895.9" "960.9" "948.0" "1061.1" "1128.1" "1300.8" "1267.8" "1323.6" "1184.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8717511238945883438" "False" "High" "IsMasterProtein" "Q12769" "Nuclear pore complex protein Nup160 OS=Homo sapiens OX=9606 GN=NUP160 PE=1 SV=3" "0.000" "False" "11.138" "2" "3" "4" "3" "1436" "162.0" "5.50" "11.70" "3" "other metabolic processes;transport;developmental processes" "cytosol;nucleus" "other molecular function" "Pf11715" "23279" "ENSG00000030066" "NUP160" "B4DYE8; B4E2J9; hsa:23279; Q08AD3; Q12769; Q7Z5X6; Q96GB3; Q9H660" "" "SUMOylation of DNA replication proteins; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "35" "0" "1.065" "1.135" "1.261" "1.021" "1.103" "1.174" "0.986" "1.093" "1.206" "65.3" "69.6" "74.1" "82.4" "66.7" "72.0" "76.7" "64.4" "71.4" "78.8" "" "" "" "" "" "" "" "" "" "" "61.2" "57.6" "68.8" "63.7" "56.9" "68.8" "70.1" "57.2" "71.4" "75.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5661386699023188299" "False" "High" "IsMasterProtein" "Q9Y4B4" "Helicase ARIP4 OS=Homo sapiens OX=9606 GN=RAD54L2 PE=1 SV=4" "0.000" "False" "11.137" "3" "3" "3" "3" "1467" "162.7" "6.09" "12.98" "3" "cell organization and biogenesis" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "23132" "ENSG00000164080" "RAD54L2" "hsa:23132; Q8TB57; Q9BV54; Q9Y4B4" "DYRK1A involvement regarding cell proliferation in brain development" "" "1" "0" "1.020" "1.076" "1.034" "1.031" "1.021" "1.017" "0.970" "0.977" "1.051" "309.7" "315.8" "333.2" "320.1" "319.3" "316.1" "314.9" "300.2" "302.6" "325.5" "" "" "" "" "" "" "" "" "" "" "290.2" "261.3" "309.3" "247.5" "272.2" "302.0" "287.8" "266.6" "302.6" "313.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8657870357206849576" "False" "High" "IsMasterProtein" "Q9Y2Y0" "ADP-ribosylation factor-like protein 2-binding protein OS=Homo sapiens OX=9606 GN=ARL2BP PE=1 SV=1" "0.000" "False" "11.131" "20" "3" "3" "3" "163" "18.8" "4.35" "12.06" "3" "signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf11527" "23568" "ENSG00000102931" "ARL2BP" "B3KQJ5; hsa:23568; Q504R0; Q9Y2Y0" "Ciliopathies" "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" "2" "0" "0.898" "0.960" "0.943" "0.943" "0.938" "0.894" "0.924" "0.954" "0.969" "627.7" "563.9" "602.7" "591.9" "592.0" "588.9" "561.0" "579.8" "598.6" "608.0" "" "" "" "" "" "" "" "" "" "" "588.1" "466.6" "559.5" "457.5" "504.6" "562.6" "512.6" "514.8" "598.6" "585.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3208052669097016746" "False" "High" "IsMasterProtein" "P51608" "Methyl-CpG-binding protein 2 OS=Homo sapiens OX=9606 GN=MECP2 PE=1 SV=1" "0.000" "False" "11.130" "7" "3" "3" "3" "486" "52.4" "9.95" "9.93" "3" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429" "4204" "ENSG00000169057" "MECP2" "hsa:4204; O15233; P51608; Q6QHH9; Q7Z384" "Ectoderm differentiation; MECP2 and associated Rett syndrome; Lung fibrosis; Rett syndrome; Transcription co-factors SKI and SKIL protein partners; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Neurogenesis regulation in the olfactory epithelium; ADHD and autism (ASD) linked metabolic pathways and SNP; Sudden infant death syndrome (SIDS) susceptibility pathways" "" "10" "0" "1.061" "1.014" "0.911" "0.990" "1.040" "1.106" "1.160" "1.135" "1.111" "292.8" "310.6" "296.8" "266.8" "289.8" "304.5" "324.0" "339.7" "332.4" "325.4" "" "" "" "" "" "" "" "" "" "" "274.4" "257.1" "275.6" "206.2" "247.0" "291.0" "296.0" "301.6" "332.4" "313.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7173448255119182363" "False" "High" "IsMasterProtein" "P27635" "Large ribosomal subunit protein uL16 OS=Homo sapiens OX=9606 GN=RPL10 PE=1 SV=5" "0.000" "False" "11.127" "20" "4" "6" "4" "214" "24.6" "10.08" "13.88" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00252" "6134" "ENSG00000147403" "RPL10" "A3KQT0; D3DWW6; hsa:6134; P27635; Q16470; Q2HXT7; Q53FH7; Q6FGN8; Q8TDA5" "Cytoplasmic ribosomal proteins; Primary ovarian insufficiency" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination" "15" "0" "1.454" "1.059" "1.118" "1.217" "1.243" "1.005" "1.099" "1.368" "1.162" "419.3" "609.8" "444.0" "468.8" "510.1" "521.1" "421.4" "460.8" "573.7" "487.3" "" "" "" "" "" "" "" "" "" "" "392.8" "504.6" "412.2" "362.4" "434.8" "497.9" "385.0" "409.1" "573.7" "469.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6108723454848240584" "False" "High" "IsMasterProtein" "Q7L7X3" "Serine/threonine-protein kinase TAO1 OS=Homo sapiens OX=9606 GN=TAOK1 PE=1 SV=1" "0.000" "False" "11.116" "4" "5" "5" "2" "1001" "116.0" "7.65" "9.18" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "57551" "ENSG00000160551" "TAOK1" "A2RUT8; B7ZLV6; hsa:57551; Q7L7X3; Q96L75; Q9H2K7; Q9H7S5; Q9P2I6" "Microtubule cytoskeleton regulation; MAPK signaling pathway" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "8" "0" "1.094" "1.059" "1.214" "1.069" "1.062" "1.119" "1.068" "1.120" "1.043" "132.5" "144.8" "140.3" "160.9" "141.6" "140.7" "148.2" "141.5" "148.4" "138.2" "" "" "" "" "" "" "" "" "" "" "124.1" "119.9" "130.3" "124.4" "120.7" "134.4" "135.4" "125.6" "148.4" "133.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5646887584104105884" "False" "High" "IsMasterProtein" "Q9BW61" "DET1- and DDB1-associated protein 1 OS=Homo sapiens OX=9606 GN=DDA1 PE=1 SV=1" "0.000" "False" "11.114" "36" "3" "5" "3" "102" "11.8" "8.68" "19.08" "3" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf10172" "79016" "ENSG00000130311" "DDA1" "hsa:79016; Q9BW61" "" "Neddylation" "1" "0" "1.051" "1.088" "1.074" "1.085" "1.050" "1.081" "1.093" "1.032" "1.054" "462.9" "486.4" "503.5" "497.0" "502.1" "486.2" "500.5" "506.0" "477.6" "488.0" "" "" "" "" "" "" "" "" "" "" "433.8" "402.5" "467.4" "384.2" "428.0" "464.5" "457.3" "449.3" "477.6" "469.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3659608677254824690" "False" "High" "IsMasterProtein" "P53582" "Methionine aminopeptidase 1 OS=Homo sapiens OX=9606 GN=METAP1 PE=1 SV=2" "0.000" "False" "11.106" "10" "4" "6" "4" "386" "43.2" "7.17" "14.15" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00557, Pf15801" "23173" "ENSG00000164024" "METAP1" "B4E2E6; hsa:23173; P53582" "" "Inactivation, recovery and regulation of the phototransduction cascade" "1" "0" "0.949" "0.972" "1.033" "0.945" "1.032" "0.945" "0.936" "1.004" "0.982" "1358.2" "1289.2" "1320.1" "1402.5" "1283.2" "1401.6" "1284.1" "1271.0" "1364.2" "1334.4" "" "" "" "" "" "" "" "" "" "" "1272.6" "1066.8" "1225.5" "1084.2" "1093.7" "1339.1" "1173.3" "1128.5" "1364.2" "1284.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1224423870794083930" "False" "High" "IsMasterProtein" "P49356" "Protein farnesyltransferase subunit beta OS=Homo sapiens OX=9606 GN=FNTB PE=1 SV=1" "0.000" "False" "11.105" "10" "4" "4" "4" "437" "48.7" "5.82" "11.96" "4" "protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00432" "100529261; 2342" "ENSG00000257365" "FNTB" "B2RDX6; B4E1A0; hsa:100529261; hsa:2342; P49356" "" "Potential therapeutics for SARS; Inactivation, recovery and regulation of the phototransduction cascade; RAS processing" "3" "0" "1.018" "0.985" "1.050" "1.002" "1.030" "1.040" "1.004" "1.007" "1.032" "455.6" "464.0" "448.6" "478.4" "456.4" "469.2" "474.0" "457.3" "458.8" "470.3" "" "" "" "" "" "" "" "" "" "" "426.9" "384.0" "416.4" "369.8" "389.0" "448.3" "433.1" "406.0" "458.8" "452.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1981774019348378929" "False" "High" "IsMasterProtein" "P0DOY2" "Immunoglobulin lambda constant 2 OS=Homo sapiens OX=9606 GN=IGLC2 PE=1 SV=1" "0.000" "False" "11.096" "27" "2" "6" "2" "106" "11.3" "7.24" "22.96" "2" "other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf07654" "" "ENSG00000211677" "IGLC2" "A0A075B6K9; A0M8Q4; P0CG05; P0CG06; P0DOY2; P80423" "" "Cell surface interactions at the vascular wall; FCGR activation; Role of LAT2/NTAL/LAB on calcium mobilization; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Initial triggering of complement; Classical antibody-mediated complement activation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Scavenging of heme from plasma; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Potential therapeutics for SARS; Regulation of Complement cascade" "19" "0" "0.922" "0.919" "0.854" "0.866" "0.830" "0.803" "0.796" "0.785" "0.828" "437.7" "403.7" "402.2" "374.0" "379.1" "363.3" "351.4" "348.2" "343.4" "362.6" "" "" "" "" "" "" "" "" "" "" "410.1" "334.1" "373.4" "289.1" "323.2" "347.1" "321.1" "309.2" "343.4" "349.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5100210059596347713" "False" "High" "IsMasterProtein" "P04899" "Guanine nucleotide-binding protein G(i) subunit alpha-2 OS=Homo sapiens OX=9606 GN=GNAI2 PE=1 SV=3" "0.000" "False" "11.093" "10" "3" "4" "2" "355" "40.4" "5.54" "13.96" "3" "cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00503" "2771" "ENSG00000114353" "GNAI2" "B3KTZ0; B4DYA0; B4E2X5; hsa:2771; P04899; Q6B6N3; Q8IZ71" "Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; S1P receptor signal transduction; Complement system; G protein signaling pathways; Chemokine signaling pathway; Hippo signaling regulation pathways; Purinergic signaling; Opioid receptor pathways; Calcium regulation in cardiac cells; 5q35 copy number variation; Serotonin HTR1 group and FOS pathway" "G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Adrenaline,noradrenaline inhibits insulin secretion" "22" "0" "0.845" "0.985" "0.916" "0.957" "1.050" "0.911" "0.979" "0.960" "1.010" "217.0" "183.4" "213.8" "198.8" "207.7" "227.8" "197.6" "212.6" "208.3" "219.2" "" "" "" "" "" "" "" "" "" "" "203.4" "151.7" "198.5" "153.6" "177.0" "217.7" "180.6" "188.7" "208.3" "211.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7473966995224482536" "False" "High" "IsMasterProtein" "Q13233" "Mitogen-activated protein kinase kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP3K1 PE=1 SV=4" "0.000" "False" "11.089" "3" "4" "5" "4" "1512" "164.4" "7.74" "9.21" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf04434, Pf21040" "4214" "ENSG00000095015" "MAP3K1" "hsa:4214; Q13233" "IL-1 signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Oxidative damage response; PDGFR-beta pathway; p38 MAPK signaling pathway; MAPK cascade; EGF/EGFR signaling pathway; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Hepatitis B infection; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Interferon type I signaling pathways; DNA damage response (only ATM dependent); Serotonin HTR1 group and FOS pathway" "MyD88:MAL(TIRAP) cascade initiated on plasma membrane; FCERI mediated MAPK activation; TRAF6 mediated NF-kB activation; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; MyD88 cascade initiated on plasma membrane" "32" "0" "0.906" "0.947" "1.102" "1.042" "1.047" "1.072" "0.987" "0.906" "0.955" "537.0" "486.5" "508.3" "591.7" "559.3" "562.1" "575.6" "530.0" "486.6" "512.9" "" "" "" "" "" "" "" "" "" "" "503.2" "402.5" "471.9" "457.4" "476.7" "537.1" "525.9" "470.6" "486.6" "493.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-325919897552027140" "False" "High" "IsMasterProtein" "Q9NW08" "DNA-directed RNA polymerase III subunit RPC2 OS=Homo sapiens OX=9606 GN=POLR3B PE=1 SV=2" "0.000" "False" "11.088" "4" "5" "5" "5" "1133" "127.7" "8.50" "14.85" "5" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04566, Pf04567" "55703" "ENSG00000013503" "POLR3B" "A8K6H0; B3KV73; F5H1E6; hsa:55703; Q9NW08; Q9NW59" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "0.959" "0.891" "1.054" "1.029" "0.867" "0.943" "0.924" "0.966" "0.972" "348.5" "334.1" "310.5" "367.3" "358.8" "302.1" "328.7" "322.0" "336.8" "338.8" "" "" "" "" "" "" "" "" "" "" "326.5" "276.5" "288.3" "283.9" "305.8" "288.6" "300.4" "285.9" "336.8" "326.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8339310688111388996" "False" "High" "IsMasterProtein" "Q9HCE5" "N6-adenosine-methyltransferase non-catalytic subunit OS=Homo sapiens OX=9606 GN=METTL14 PE=1 SV=2" "0.000" "False" "11.087" "7" "3" "4" "3" "456" "52.1" "6.21" "17.92" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05063" "57721" "ENSG00000145388" "METTL14" "A6NIG1; hsa:57721; Q969V2; Q9HCE5" "1p36 copy number variation syndrome" "Processing of Capped Intron-Containing Pre-mRNA" "2" "0" "1.062" "1.125" "1.088" "1.162" "1.085" "1.083" "1.187" "1.186" "1.106" "399.5" "424.3" "449.5" "434.6" "464.4" "433.6" "432.6" "474.4" "473.9" "442.0" "" "" "" "" "" "" "" "" "" "" "374.4" "351.1" "417.3" "336.0" "395.8" "414.2" "395.3" "421.2" "473.9" "425.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5894079024390586831" "False" "High" "IsMasterProtein" "Q9NQ29" "Putative RNA-binding protein Luc7-like 1 OS=Homo sapiens OX=9606 GN=LUC7L PE=1 SV=1" "0.000" "False" "11.087" "10" "4" "4" "2" "371" "43.7" "9.92" "12.75" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03194" "55692" "ENSG00000007392" "LUC7L" "B8ZZ13; hsa:55692; Q96S32; Q9NPH4; Q9NQ29" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.097" "1.229" "1.060" "1.083" "1.083" "1.162" "1.226" "1.144" "1.051" "104.1" "114.2" "127.9" "110.3" "112.7" "112.8" "121.0" "127.6" "119.1" "109.5" "" "" "" "" "" "" "" "" "" "" "97.5" "94.5" "118.8" "85.3" "96.1" "107.7" "110.5" "113.3" "119.1" "105.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6116188343313863326" "False" "High" "IsMasterProtein" "Q6P1L8" "Large ribosomal subunit protein uL14m OS=Homo sapiens OX=9606 GN=MRPL14 PE=1 SV=1" "0.000" "False" "11.073" "30" "3" "3" "3" "145" "15.9" "10.24" "11.59" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00238" "64928" "ENSG00000180992" "MRPL14" "B2R575; hsa:64928; Q6P1L8; Q96Q72" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.066" "1.017" "1.091" "1.069" "0.981" "1.040" "1.020" "1.004" "0.991" "152.5" "162.5" "155.0" "166.3" "163.0" "149.6" "158.6" "155.5" "153.0" "151.1" "" "" "" "" "" "" "" "" "" "" "142.9" "134.5" "143.9" "128.6" "139.0" "143.0" "144.9" "138.0" "153.0" "145.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1492167490634941437" "False" "High" "IsMasterProtein" "P49914" "5-formyltetrahydrofolate cyclo-ligase OS=Homo sapiens OX=9606 GN=MTHFS PE=1 SV=2" "0.000" "False" "11.064" "27" "5" "7" "5" "203" "23.2" "7.88" "15.69" "5" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01812" "10588" "ENSG00000136371" "MTHFS" "H3BQ75; hsa:10588; P49914" "Folate metabolism; One-carbon metabolism; Disorders of folate metabolism and transport" "Metabolism of folate and pterines" "4" "0" "1.000" "1.088" "1.045" "1.013" "1.046" "0.910" "1.049" "1.105" "1.087" "356.5" "356.5" "388.1" "372.6" "361.3" "372.8" "324.4" "374.0" "393.9" "387.7" "" "" "" "" "" "" "" "" "" "" "334.1" "295.0" "360.3" "288.0" "307.9" "356.2" "296.4" "332.1" "393.9" "373.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8494127544242029271" "False" "High" "IsMasterProtein" "P62249" "Small ribosomal subunit protein uS9 OS=Homo sapiens OX=9606 GN=RPS16 PE=1 SV=2" "0.000" "False" "11.048" "27" "5" "5" "5" "146" "16.4" "10.21" "14.27" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00380" "6217" "ENSG00000105193" "RPS16" "B2RDD5; hsa:6217; P17008; P62249" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.107" "1.321" "1.076" "1.135" "1.207" "1.486" "1.446" "1.478" "1.235" "529.4" "585.9" "699.5" "569.7" "601.0" "638.7" "786.4" "765.4" "782.4" "654.0" "" "" "" "" "" "" "" "" "" "" "496.0" "484.8" "649.4" "440.4" "512.3" "610.3" "718.6" "679.6" "782.4" "629.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7987145187797725947" "False" "High" "IsMasterProtein" "Q9H6R0" "ATP-dependent RNA helicase DHX33 OS=Homo sapiens OX=9606 GN=DHX33 PE=1 SV=2" "0.000" "False" "11.043" "6" "4" "4" "4" "707" "78.8" "8.91" "12.69" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "56919" "ENSG00000005100" "DHX33" "B4DHF9; hsa:56919; Q4G149; Q5CZ73; Q9H5M9; Q9H6R0" "" "" "0" "0" "1.059" "0.953" "1.241" "1.172" "1.044" "1.247" "1.282" "1.183" "1.130" "390.9" "414.0" "372.4" "484.9" "458.2" "408.1" "487.4" "501.2" "462.4" "441.8" "" "" "" "" "" "" "" "" "" "" "366.2" "342.6" "345.7" "374.9" "390.6" "389.9" "445.3" "445.1" "462.4" "425.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3163608174618773486" "False" "High" "IsMasterProtein" "Q5SXM2" "snRNA-activating protein complex subunit 4 OS=Homo sapiens OX=9606 GN=SNAPC4 PE=1 SV=1" "0.000" "False" "11.041" "4" "5" "5" "4" "1469" "159.3" "8.28" "10.84" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13921" "6621" "ENSG00000165684" "SNAPC4" "hsa:6621; Q5SXM2; Q9Y6P7" "" "RNA polymerase II transcribes snRNA genes; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter" "3" "0" "0.938" "0.950" "1.012" "1.095" "0.908" "0.868" "0.831" "0.892" "0.942" "184.9" "173.5" "175.7" "187.0" "202.4" "167.8" "160.4" "153.6" "164.8" "174.2" "" "" "" "" "" "" "" "" "" "" "173.2" "143.6" "163.1" "144.6" "172.5" "160.3" "146.6" "136.4" "164.8" "167.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1135518619596976792" "False" "High" "IsMasterProtein" "B7ZBB8" "Protein phosphatase 1 regulatory subunit 3G OS=Homo sapiens OX=9606 GN=PPP1R3G PE=1 SV=1" "0.000" "False" "11.041" "12" "3" "4" "3" "358" "38.0" "4.93" "15.75" "3" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf03370" "648791" "ENSG00000219607" "PPP1R3G" "B7ZBB8; hsa:648791" "" "" "0" "0" "0.978" "0.967" "1.049" "1.033" "0.977" "0.919" "0.911" "0.948" "1.022" "332.6" "325.4" "321.5" "348.8" "343.4" "324.8" "305.6" "303.1" "315.3" "339.9" "" "" "" "" "" "" "" "" "" "" "311.6" "269.2" "298.5" "269.6" "292.7" "310.3" "279.3" "269.2" "315.3" "327.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8531789863272175239" "False" "High" "IsMasterProtein" "Q9BU89" "Deoxyhypusine hydroxylase OS=Homo sapiens OX=9606 GN=DOHH PE=1 SV=1" "0.000" "False" "11.034" "15" "3" "3" "3" "302" "32.9" "4.83" "13.33" "3" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf13646" "83475" "ENSG00000129932" "DOHH" "O75265; Q9BU89" "" "Hypusine synthesis from eIF5A-lysine" "1" "0" "1.096" "0.938" "1.304" "1.115" "0.991" "1.170" "1.013" "0.891" "1.049" "226.8" "248.5" "212.7" "295.7" "252.9" "224.8" "265.4" "229.6" "202.0" "237.9" "" "" "" "" "" "" "" "" "" "" "212.5" "205.6" "197.5" "228.6" "215.6" "214.8" "242.5" "203.9" "202.0" "229.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8722067118007621165" "False" "High" "IsMasterProtein" "P23497" "Nuclear autoantigen Sp-100 OS=Homo sapiens OX=9606 GN=SP100 PE=1 SV=3" "0.000" "False" "11.034" "4" "4" "4" "3" "879" "100.4" "8.22" "9.18" "4" "cell organization and biogenesis;DNA metabolism;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf01342, Pf03172, Pf09011" "6672" "ENSG00000067066" "SP100" "B4DDX5; B8ZZD8; E7EUA7; E9PH61; F8WFE2; hsa:6672; O75450; P23497; Q13343; Q8TE34; Q96F70; Q96T24; Q96T95; Q9NP33; Q9UE32" "" "SUMOylation of DNA damage response and repair proteins; Interferon gamma signaling" "2" "0" "0.980" "0.995" "1.087" "1.077" "1.083" "1.063" "1.067" "1.100" "1.077" "584.7" "573.1" "581.5" "635.4" "629.8" "633.4" "621.7" "623.9" "643.4" "629.5" "" "" "" "" "" "" "" "" "" "" "547.9" "474.2" "539.8" "491.2" "536.9" "605.2" "568.1" "553.9" "643.4" "606.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9053740260663860944" "False" "High" "IsMasterProtein" "Q9NZN8" "CCR4-NOT transcription complex subunit 2 OS=Homo sapiens OX=9606 GN=CNOT2 PE=1 SV=1" "0.000" "False" "11.030" "8" "4" "4" "4" "540" "59.7" "7.66" "8.66" "4" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04153" "4848" "ENSG00000111596" "CNOT2" "hsa:4848; Q9H3E0; Q9NSX5; Q9NWR6; Q9NZN8; Q9P028" "" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "1.082" "0.992" "1.008" "1.005" "0.968" "1.183" "1.052" "1.072" "1.016" "595.6" "644.3" "590.9" "600.5" "598.6" "576.8" "704.5" "626.6" "638.7" "605.2" "" "" "" "" "" "" "" "" "" "" "558.1" "533.1" "548.6" "464.2" "510.3" "551.1" "643.7" "556.3" "638.7" "582.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2014146262064774288" "False" "High" "IsMasterProtein" "P09001" "Large ribosomal subunit protein uL3m OS=Homo sapiens OX=9606 GN=MRPL3 PE=1 SV=1" "0.000" "False" "11.025" "9" "3" "6" "3" "348" "38.6" "9.48" "21.31" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00297" "11222" "ENSG00000114686" "MRPL3" "hsa:11222; P09001; Q6IBT2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.091" "1.107" "1.076" "1.101" "1.122" "1.078" "1.049" "1.067" "1.064" "324.6" "354.0" "359.1" "349.3" "357.4" "364.2" "349.9" "340.3" "346.3" "345.2" "" "" "" "" "" "" "" "" "" "" "304.1" "292.9" "333.4" "270.0" "304.6" "348.0" "319.7" "302.2" "346.3" "332.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6884862282451345768" "False" "High" "IsMasterProtein" "Q9Y232" "Chromodomain Y-like protein OS=Homo sapiens OX=9606 GN=CDYL PE=1 SV=2" "0.000" "False" "11.024" "6" "4" "4" "4" "598" "66.4" "9.45" "11.01" "4" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00378, Pf00385" "9425" "ENSG00000153046" "CDYL" "A8K6D6; B4DLG4; hsa:9425; Q0VDG7; Q32NC5; Q5VX99; Q6P7T5; Q9BWZ2; Q9Y232; Q9Y424" "" "" "0" "0" "0.952" "1.083" "0.997" "1.072" "1.005" "1.142" "1.096" "1.115" "1.059" "779.3" "742.3" "843.7" "777.2" "835.6" "783.3" "889.9" "854.2" "868.9" "825.7" "" "" "" "" "" "" "" "" "" "" "730.2" "614.3" "783.3" "600.8" "712.3" "748.4" "813.1" "758.4" "868.9" "795.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8192519440703409270" "False" "High" "IsMasterProtein" "Q8NB37" "Glutamine amidotransferase-like class 1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GATD1 PE=1 SV=1" "0.000" "False" "11.022" "14" "3" "4" "3" "220" "23.3" "6.61" "11.76" "3" "other metabolic processes" "other cell component" "other molecular function" "" "347862" "ENSG00000177225" "GATD1" "B7ZKW5; hsa:347862; Q2NL76; Q6ZQY0; Q8NAE0; Q8NB37" "" "" "0" "0" "0.882" "0.932" "0.852" "1.040" "0.969" "0.926" "0.921" "0.978" "0.888" "92.1" "81.2" "85.9" "78.5" "95.8" "89.2" "85.3" "84.8" "90.1" "81.8" "" "" "" "" "" "" "" "" "" "" "86.3" "67.2" "79.7" "60.7" "81.6" "85.3" "77.9" "75.3" "90.1" "78.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8560465734379748063" "False" "High" "IsMasterProtein" "Q9NP77" "RNA polymerase II subunit A C-terminal domain phosphatase SSU72 OS=Homo sapiens OX=9606 GN=SSU72 PE=1 SV=1" "0.000" "False" "11.018" "17" "3" "4" "3" "194" "22.6" "5.33" "15.63" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04722" "29101" "ENSG00000160075" "SSU72" "hsa:29101; Q9BZS6; Q9H933; Q9NP77" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.121" "1.006" "1.036" "1.167" "1.107" "1.124" "1.145" "1.189" "1.140" "601.0" "673.9" "604.5" "622.6" "701.4" "665.3" "675.8" "688.4" "714.4" "684.9" "" "" "" "" "" "" "" "" "" "" "563.2" "557.7" "561.2" "481.3" "597.9" "635.7" "617.5" "611.2" "714.4" "659.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2886709730536475345" "False" "High" "IsMasterProtein" "Q9BTT0" "Acidic leucine-rich nuclear phosphoprotein 32 family member E OS=Homo sapiens OX=9606 GN=ANP32E PE=1 SV=1" "0.000" "False" "11.013" "15" "3" "5" "3" "268" "30.7" "3.85" "16.41" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf14580" "81611" "ENSG00000143401" "ANP32E" "B4E0I6; E9PEA6; hsa:81611; Q5TB18; Q5TB20; Q8N1S4; Q8WWW9; Q9BTT0" "" "" "0" "0" "0.948" "1.077" "1.273" "1.230" "1.168" "1.173" "1.105" "1.081" "1.122" "94.0" "89.2" "101.3" "119.7" "115.7" "109.8" "110.3" "103.9" "101.7" "105.5" "" "" "" "" "" "" "" "" "" "" "88.1" "73.8" "94.1" "92.6" "98.6" "104.9" "100.8" "92.3" "101.7" "101.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6634047056467408227" "False" "High" "IsMasterProtein" "P62318" "Small nuclear ribonucleoprotein Sm D3 OS=Homo sapiens OX=9606 GN=SNRPD3 PE=1 SV=1" "0.000" "False" "11.010" "32" "3" "7" "3" "126" "13.9" "10.32" "21.77" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "6634" "ENSG00000100028" "SNRPD3" "B4DJP7; B5BU13; hsa:6634; P43331; P62318" "mRNA processing" "RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; snRNP Assembly; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "1.088" "1.225" "1.086" "1.118" "1.172" "1.112" "1.196" "1.217" "1.086" "455.3" "495.2" "557.9" "494.4" "509.1" "533.7" "506.3" "544.8" "554.3" "494.4" "" "" "" "" "" "" "" "" "" "" "426.6" "409.8" "517.9" "382.2" "433.9" "509.9" "462.7" "483.7" "554.3" "476.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3431130476793294573" "False" "High" "IsMasterProtein" "Q8IUR0" "Trafficking protein particle complex subunit 5 OS=Homo sapiens OX=9606 GN=TRAPPC5 PE=1 SV=1" "0.000" "False" "11.005" "18" "4" "5" "4" "188" "20.8" "9.66" "16.91" "4" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "126003" "ENSG00000181029" "TRAPPC5" "A8K7I6; hsa:126003; Q8IUR0" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "1.068" "1.124" "1.235" "1.124" "1.039" "1.092" "1.092" "1.123" "1.118" "400.1" "427.4" "449.9" "494.0" "449.9" "415.7" "437.1" "436.8" "449.4" "447.2" "" "" "" "" "" "" "" "" "" "" "374.9" "353.7" "417.6" "381.9" "383.5" "397.2" "399.3" "387.8" "449.4" "430.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3279905099390366435" "False" "High" "IsMasterProtein" "Q6FIF0" "AN1-type zinc finger protein 6 OS=Homo sapiens OX=9606 GN=ZFAND6 PE=1 SV=2" "0.000" "False" "10.998" "21" "3" "3" "3" "208" "22.5" "7.20" "12.18" "3" "cell organization and biogenesis;other biological processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf01428, Pf01754" "54469" "ENSG00000086666" "ZFAND6" "D3DW92; D3DW94; hsa:54469; O95792; Q6FIF0; Q9BQF7; Q9GZY3" "" "Peroxisomal protein import" "1" "0" "1.349" "1.128" "1.179" "1.216" "1.143" "1.119" "1.003" "1.209" "1.304" "114.0" "153.7" "128.6" "134.4" "138.6" "130.2" "127.5" "114.4" "137.8" "148.6" "" "" "" "" "" "" "" "" "" "" "106.8" "127.2" "119.4" "103.9" "118.1" "124.4" "116.5" "101.5" "137.8" "143.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7056878073192047652" "False" "High" "IsMasterProtein" "Q96JM7" "Lethal(3)malignant brain tumor-like protein 3 OS=Homo sapiens OX=9606 GN=L3MBTL3 PE=1 SV=2" "0.000" "False" "10.992" "5" "3" "3" "3" "780" "88.3" "6.46" "10.76" "3" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf00536, Pf02820" "84456" "ENSG00000198945" "L3MBTL3" "hsa:84456; Q4VXE1; Q5VUM9; Q6P9B5; Q96JM7" "" "" "0" "0" "1.082" "0.952" "1.165" "1.150" "1.132" "1.130" "0.990" "0.966" "1.078" "95.9" "103.8" "91.3" "111.7" "110.3" "108.6" "108.3" "94.9" "92.6" "103.4" "" "" "" "" "" "" "" "" "" "" "89.8" "85.9" "84.8" "86.4" "94.0" "103.7" "99.0" "84.3" "92.6" "99.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "316205606070741097" "False" "High" "IsMasterProtein" "Q5JTD0" "Tight junction-associated protein 1 OS=Homo sapiens OX=9606 GN=TJAP1 PE=1 SV=1" "0.000" "False" "10.984" "6" "3" "3" "3" "557" "61.8" "5.97" "12.27" "3" "cell organization and biogenesis" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf15453" "93643" "ENSG00000137221" "TJAP1" "hsa:93643; Q05BH9; Q5JTD0; Q5JTD1; Q5JWW1; Q68DB2; Q6P2P3; Q9H7V7" "" "" "0" "0" "1.117" "0.939" "1.148" "1.099" "1.039" "1.018" "0.976" "0.929" "0.986" "253.9" "283.6" "238.4" "291.5" "279.0" "263.7" "258.5" "247.8" "235.8" "250.3" "" "" "" "" "" "" "" "" "" "" "237.9" "234.6" "221.3" "225.4" "237.8" "252.0" "236.2" "220.0" "235.8" "241.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2687801448742430149" "False" "High" "IsMasterProtein" "Q9H4A6" "Golgi phosphoprotein 3 OS=Homo sapiens OX=9606 GN=GOLPH3 PE=1 SV=1" "0.000" "False" "10.977" "15" "5" "5" "5" "298" "33.8" "6.44" "13.20" "5" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05719" "64083" "ENSG00000113384" "GOLPH3" "hsa:64083; Q9H4A6; Q9UIW5" "" "" "0" "0" "1.121" "0.986" "1.062" "1.132" "0.982" "1.049" "0.957" "1.022" "1.015" "247.5" "277.4" "244.0" "262.9" "280.3" "243.1" "259.7" "236.9" "252.9" "251.2" "" "" "" "" "" "" "" "" "" "" "231.9" "229.6" "226.5" "203.2" "238.9" "232.2" "237.3" "210.4" "252.9" "241.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6341568024441871550" "False" "High" "IsMasterProtein" "O75131" "Copine-3 OS=Homo sapiens OX=9606 GN=CPNE3 PE=1 SV=1" "0.000" "False" "10.970" "6" "4" "4" "4" "537" "60.1" "5.85" "11.67" "4" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00168, Pf07002" "8895" "ENSG00000085719" "CPNE3" "A8KA47; hsa:8895; O75131; Q8IYA1" "" "Neutrophil degranulation; Glycerophospholipid biosynthesis" "2" "0" "1.010" "1.266" "1.051" "1.188" "1.212" "1.079" "1.204" "1.193" "1.260" "181.3" "183.1" "229.6" "190.6" "215.5" "219.8" "195.7" "218.4" "216.3" "228.6" "" "" "" "" "" "" "" "" "" "" "169.9" "151.5" "213.2" "147.3" "183.7" "210.0" "178.9" "193.9" "216.3" "220.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-398928808883879512" "False" "High" "IsMasterProtein" "P07311" "Acylphosphatase-1 OS=Homo sapiens OX=9606 GN=ACYP1 PE=1 SV=2" "0.000" "False" "10.960" "36" "4" "4" "4" "99" "11.3" "9.31" "13.57" "4" "other metabolic processes" "" "other molecular function" "Pf00708" "97" "ENSG00000119640" "ACYP1" "A6NDV8; B2R590; hsa:97; P07311" "" "" "0" "0" "1.028" "1.140" "1.133" "0.998" "0.993" "0.964" "1.081" "1.058" "1.120" "343.9" "353.4" "392.0" "389.7" "343.3" "341.6" "331.4" "371.6" "363.9" "385.2" "" "" "" "" "" "" "" "" "" "" "322.2" "292.4" "363.9" "301.3" "292.6" "326.3" "302.8" "330.0" "363.9" "370.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4936048942270731480" "False" "High" "IsMasterProtein" "O00567" "Nucleolar protein 56 OS=Homo sapiens OX=9606 GN=NOP56 PE=1 SV=4" "0.000" "False" "10.958" "7" "4" "4" "4" "594" "66.0" "9.19" "10.67" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01798, Pf08156" "10528" "ENSG00000101361" "NOP56" "hsa:10528; O00567; Q2M3T6; Q9NQ05" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Association of TriC/CCT with target proteins during biosynthesis" "3" "0" "1.022" "0.911" "1.094" "1.160" "0.997" "1.137" "1.145" "1.614" "1.083" "107.8" "110.1" "98.2" "117.9" "125.0" "107.5" "122.6" "123.4" "174.0" "116.8" "" "" "" "" "" "" "" "" "" "" "101.0" "91.1" "91.1" "91.1" "106.5" "102.7" "112.0" "109.5" "174.0" "112.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-475093268658479309" "False" "High" "IsMasterProtein" "P61599" "N-alpha-acetyltransferase 20 OS=Homo sapiens OX=9606 GN=NAA20 PE=1 SV=1" "0.000" "False" "10.936" "24" "4" "5" "4" "178" "20.4" "5.03" "14.98" "4" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "51126" "ENSG00000173418" "NAA20" "A6NHA3; B2R4G4; hsa:51126; P61599; Q5TFT7; Q9D7H8; Q9H0Y4; Q9NQH6; Q9Y6D2" "Metapathway biotransformation Phase I and II" "" "1" "0" "1.092" "0.905" "0.971" "1.053" "1.015" "0.963" "1.058" "1.174" "0.946" "40.2" "43.9" "36.4" "39.0" "42.3" "40.8" "38.7" "42.6" "47.2" "38.1" "" "" "" "" "" "" "" "" "" "" "37.7" "36.3" "33.8" "30.2" "36.1" "39.0" "35.4" "37.8" "47.2" "36.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8434101151437963191" "False" "High" "IsMasterProtein" "Q7Z2K8" "G protein-regulated inducer of neurite outgrowth 1 OS=Homo sapiens OX=9606 GN=GPRIN1 PE=1 SV=2" "0.000" "False" "10.912" "5" "5" "5" "5" "1008" "102.3" "8.06" "10.38" "5" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf15235" "114787" "ENSG00000169258" "GPRIN1" "C9JM70; hsa:114787; Q7Z2K8; Q8ND74; Q96PZ4" "MECP2 and associated Rett syndrome; 5q35 copy number variation" "MECP2 regulates neuronal receptors and channels" "3" "0" "1.051" "1.055" "1.204" "1.062" "1.006" "1.071" "1.110" "1.021" "1.031" "319.5" "335.6" "337.1" "384.7" "339.4" "321.5" "342.1" "354.7" "326.3" "329.3" "" "" "" "" "" "" "" "" "" "" "299.3" "277.7" "312.9" "297.4" "289.3" "307.2" "312.5" "314.9" "326.3" "317.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8771434071682940528" "False" "High" "IsMasterProtein" "O95294" "RasGAP-activating-like protein 1 OS=Homo sapiens OX=9606 GN=RASAL1 PE=1 SV=3" "0.000" "False" "10.901" "6" "5" "6" "5" "804" "90.0" "6.51" "13.30" "5" "signal transduction;other biological processes" "cytosol" "enzyme regulator activity;other molecular function" "Pf00168, Pf00169, Pf00616, Pf00779" "8437" "ENSG00000111344" "RASAL1" "B7ZKM4; C9JFK5; F8VQX1; hsa:8437; O95294; Q52M03; Q59H24; Q96CC7" "Ras signaling" "Regulation of RAS by GAPs" "2" "0" "0.990" "1.045" "1.055" "1.047" "1.016" "1.024" "0.998" "0.963" "1.016" "356.5" "353.0" "372.6" "376.0" "373.2" "362.1" "365.0" "355.9" "343.2" "362.0" "" "" "" "" "" "" "" "" "" "" "334.0" "292.1" "345.9" "290.7" "318.1" "346.0" "333.5" "316.0" "343.2" "348.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5643527966773386320" "False" "High" "IsMasterProtein" "Q8IWZ8" "SURP and G-patch domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SUGP1 PE=1 SV=2" "0.000" "False" "10.900" "6" "3" "4" "3" "645" "72.4" "7.61" "14.41" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf01585, Pf01805" "57794" "ENSG00000105705" "SUGP1" "hsa:57794; O60378; Q6P3X9; Q8IWZ8; Q8TCQ4; Q8WWT4; Q8WWT5; Q9NTG3" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.985" "0.937" "1.081" "1.093" "1.100" "1.234" "1.258" "1.221" "1.181" "460.7" "453.9" "431.7" "497.8" "503.5" "506.6" "568.3" "579.3" "562.6" "544.1" "" "" "" "" "" "" "" "" "" "" "431.6" "375.6" "400.8" "384.8" "429.2" "484.0" "519.2" "514.4" "562.6" "523.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3115833996025844865" "False" "High" "IsMasterProtein" "P19447" "General transcription and DNA repair factor IIH helicase/translocase subunit XPB OS=Homo sapiens OX=9606 GN=ERCC3 PE=1 SV=1" "0.000" "False" "10.886" "5" "3" "4" "3" "782" "89.2" "7.23" "15.82" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04851, Pf13625, Pf16203" "2071" "ENSG00000163161" "ERCC3" "hsa:2071; P19447; Q53QM0" "Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "33" "0" "1.009" "1.059" "1.125" "1.147" "1.114" "1.121" "1.179" "1.175" "1.139" "445.2" "449.1" "471.5" "500.7" "510.6" "496.1" "499.0" "524.9" "523.3" "507.2" "" "" "" "" "" "" "" "" "" "" "417.2" "371.6" "437.8" "387.1" "435.2" "474.0" "455.9" "466.0" "523.3" "488.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-27127465578060112" "False" "High" "IsMasterProtein" "Q96SU4" "Oxysterol-binding protein-related protein 9 OS=Homo sapiens OX=9606 GN=OSBPL9 PE=1 SV=2" "0.000" "False" "10.883" "5" "4" "5" "4" "736" "83.1" "6.18" "16.68" "4" "other metabolic processes;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "114883" "ENSG00000117859" "OSBPL9" "B1AKJ8; B3KPQ4; D3DQ31; hsa:114883; Q5TFC0; Q6IA67; Q86YQ3; Q8NB17; Q8TAS8; Q96SK4; Q96SU4; Q9H9X2" "" "Synthesis of bile acids and bile salts" "1" "0" "0.989" "1.007" "0.916" "0.973" "0.975" "0.926" "0.919" "0.862" "0.962" "622.3" "615.7" "626.7" "569.7" "605.3" "607.0" "576.0" "571.7" "536.2" "598.5" "" "" "" "" "" "" "" "" "" "" "583.1" "509.5" "581.8" "440.4" "516.0" "579.9" "526.3" "507.6" "536.2" "576.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6270565792586481652" "False" "High" "IsMasterProtein" "Q9UHY7" "Enolase-phosphatase E1 OS=Homo sapiens OX=9606 GN=ENOPH1 PE=1 SV=1" "0.000" "False" "10.871" "9" "2" "5" "2" "261" "28.9" "4.78" "17.74" "2" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00702" "58478" "ENSG00000145293" "ENOPH1" "hsa:58478; Q7Z4C5; Q9BVC2; Q9UHY7" "Methionine de novo and salvage pathway" "Methionine salvage pathway" "2" "0" "1.062" "0.987" "1.066" "1.096" "0.978" "1.137" "1.054" "1.004" "0.972" "222.3" "236.2" "219.4" "237.0" "243.5" "217.4" "252.7" "234.3" "223.1" "216.1" "" "" "" "" "" "" "" "" "" "" "208.3" "195.4" "203.7" "183.2" "207.6" "207.7" "230.9" "208.1" "223.1" "208.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3778187452605941811" "False" "High" "IsMasterProtein" "Q9NZ52" "ADP-ribosylation factor-binding protein GGA3 OS=Homo sapiens OX=9606 GN=GGA3 PE=1 SV=1" "0.000" "False" "10.859" "5" "4" "6" "3" "723" "78.3" "5.58" "14.82" "4" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "23163" "ENSG00000125447" "GGA3" "B7Z7E2; B7Z7M9; hsa:23163; J3KRN0; Q15017; Q6IS16; Q9NZ52; Q9UJY3" "" "Amyloid fiber formation; TBC/RABGAPs; MET receptor recycling" "3" "0" "1.022" "1.050" "1.009" "1.040" "1.007" "0.966" "1.023" "1.022" "1.051" "856.2" "875.4" "899.2" "863.7" "890.5" "861.9" "827.2" "876.0" "875.1" "899.8" "" "" "" "" "" "" "" "" "" "" "802.2" "724.4" "834.8" "667.7" "759.0" "823.4" "755.8" "777.8" "875.1" "866.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2810950685469585295" "False" "High" "IsMasterProtein" "Q2TBE0" "CWF19-like protein 2 OS=Homo sapiens OX=9606 GN=CWF19L2 PE=1 SV=4" "0.000" "False" "10.859" "4" "4" "6" "4" "894" "103.7" "8.65" "14.20" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf04676, Pf04677" "143884" "ENSG00000152404" "CWF19L2" "A4FU66; A4FU67; A4FU68; A8KAD6; hsa:143884; Q2TBE0; Q6PHW1; Q96MI1" "" "mRNA Splicing - Major Pathway" "1" "0" "1.022" "1.041" "1.137" "1.047" "0.987" "1.141" "1.026" "1.009" "1.054" "404.5" "413.4" "421.1" "459.8" "423.6" "399.4" "461.5" "415.0" "408.3" "426.5" "" "" "" "" "" "" "" "" "" "" "379.0" "342.1" "391.0" "355.5" "361.1" "381.6" "421.6" "368.5" "408.3" "410.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2753763641550930270" "False" "High" "IsMasterProtein" "Q96NB3" "Zinc finger protein 830 OS=Homo sapiens OX=9606 GN=ZNF830 PE=1 SV=2" "0.000" "False" "10.853" "10" "3" "3" "3" "372" "42.0" "5.31" "11.68" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12874" "91603" "ENSG00000198783" "ZNF830" "hsa:91603; Q96F60; Q96GZ5; Q96NB3; Q9BU38" "17q12 copy number variation syndrome" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "6" "0" "1.143" "1.018" "1.110" "1.116" "1.077" "1.208" "1.180" "1.033" "1.087" "202.6" "231.7" "206.2" "225.0" "226.1" "218.2" "244.7" "239.1" "209.3" "220.3" "" "" "" "" "" "" "" "" "" "" "189.9" "191.7" "191.5" "173.9" "192.8" "208.5" "223.6" "212.3" "209.3" "212.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5802259196988862678" "False" "High" "IsMasterProtein" "Q9NUY8" "TBC1 domain family member 23 OS=Homo sapiens OX=9606 GN=TBC1D23 PE=1 SV=3" "0.000" "False" "10.851" "5" "4" "4" "4" "699" "78.3" "5.41" "13.44" "4" "cell organization and biogenesis;transport;developmental processes" "cytosol;ER/Golgi;other cell component" "" "Pf00566, Pf00581, Pf19430" "55773" "ENSG00000036054" "TBC1D23" "B9A6M5; hsa:55773; Q8TCN8; Q8WUB7; Q96D90; Q9NUY8; Q9NV75" "" "" "0" "0" "0.968" "0.972" "1.026" "0.977" "0.973" "0.994" "0.934" "0.962" "0.971" "771.8" "747.2" "750.0" "791.8" "754.4" "750.8" "767.1" "721.2" "742.3" "749.5" "" "" "" "" "" "" "" "" "" "" "723.2" "618.3" "696.3" "612.1" "643.0" "717.3" "700.9" "640.3" "742.3" "721.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-822484129541956869" "False" "High" "IsMasterProtein" "Q14149" "MORC family CW-type zinc finger protein 3 OS=Homo sapiens OX=9606 GN=MORC3 PE=1 SV=3" "0.000" "False" "10.825" "5" "5" "5" "4" "939" "107.0" "5.60" "14.69" "5" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07496, Pf13589, Pf17942" "23515" "ENSG00000159256" "MORC3" "A8KA92; hsa:23515; Q14149; Q9UEZ2" "Interactome of polycomb repressive complex 2 (PRC2)" "" "1" "0" "0.939" "0.963" "0.975" "0.996" "0.996" "1.009" "0.993" "1.017" "1.027" "554.6" "520.8" "534.2" "540.7" "552.1" "552.6" "559.9" "550.6" "564.1" "569.6" "" "" "" "" "" "" "" "" "" "" "519.7" "431.0" "496.0" "418.0" "470.6" "528.0" "511.6" "488.8" "564.1" "548.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6180191668945880169" "False" "High" "IsMasterProtein" "Q9H269" "Vacuolar protein sorting-associated protein 16 homolog OS=Homo sapiens OX=9606 GN=VPS16 PE=1 SV=2" "0.000" "False" "10.824" "4" "4" "4" "4" "839" "94.6" "6.77" "11.96" "4" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf04840, Pf04841" "64601" "ENSG00000215305" "VPS16" "hsa:64601; Q5JUB1; Q8WU31; Q96EE7; Q96N92; Q9H1Q4; Q9H1Q5; Q9H269" "Ebola virus infection in host; Network map of SARS-CoV-2 signaling pathway" "SARS-CoV-2 modulates autophagy" "3" "0" "1.010" "0.979" "0.931" "0.939" "0.926" "0.935" "0.894" "0.935" "0.962" "226.6" "229.0" "221.9" "210.9" "212.8" "209.8" "211.9" "202.5" "211.9" "217.9" "" "" "" "" "" "" "" "" "" "" "212.3" "189.5" "206.0" "163.0" "181.3" "200.5" "193.7" "179.8" "211.9" "209.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7603913648578901731" "False" "High" "IsMasterProtein" "Q5VWZ2" "Lysophospholipase-like protein 1 OS=Homo sapiens OX=9606 GN=LYPLAL1 PE=1 SV=3" "0.000" "False" "10.813" "14" "4" "5" "4" "237" "26.3" "7.84" "16.03" "4" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02230" "127018" "ENSG00000143353" "LYPLAL1" "A8K677; hsa:127018; Q5VWZ2; Q5VWZ3; Q7Z4A3; Q96AV0" "" "" "0" "0" "0.939" "0.958" "0.973" "0.951" "0.933" "0.949" "0.964" "0.908" "0.922" "1052.0" "988.2" "1007.8" "1024.1" "1000.7" "981.6" "998.8" "1013.8" "954.8" "969.5" "" "" "" "" "" "" "" "" "" "" "985.7" "817.7" "935.6" "791.7" "853.0" "937.8" "912.6" "900.1" "954.8" "933.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1141936988023863748" "False" "High" "IsMasterProtein" "Q9NP61" "ADP-ribosylation factor GTPase-activating protein 3 OS=Homo sapiens OX=9606 GN=ARFGAP3 PE=1 SV=1" "0.000" "False" "10.803" "8" "5" "5" "5" "516" "56.9" "7.36" "13.43" "5" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf01412" "26286" "ENSG00000242247" "ARFGAP3" "E9PB03; hsa:26286; Q9BSC6; Q9H9J0; Q9NP61; Q9NT10; Q9NUP5; Q9Y4V3; Q9Y4V4" "Ciliary landscape" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; CDC42 GTPase cycle; RHOG GTPase cycle" "5" "0" "0.969" "0.915" "0.842" "1.002" "1.011" "0.854" "0.891" "0.932" "0.974" "539.0" "522.4" "493.5" "453.6" "539.9" "544.8" "460.3" "480.3" "502.2" "525.2" "" "" "" "" "" "" "" "" "" "" "505.1" "432.3" "458.1" "350.7" "460.2" "520.5" "420.6" "426.5" "502.2" "505.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3818907558764607522" "False" "High" "IsMasterProtein" "Q8IWD4" "Coiled-coil domain-containing protein 117 OS=Homo sapiens OX=9606 GN=CCDC117 PE=1 SV=1" "0.000" "False" "10.801" "13" "4" "4" "4" "279" "30.5" "5.07" "13.58" "4" "other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf15810" "150275" "ENSG00000159873" "CCDC117" "A8K0F1; B7Z2V1; B7Z860; hsa:150275; Q6ICA7; Q8IWD4; Q8N278" "" "" "0" "0" "1.034" "0.996" "1.048" "0.990" "1.068" "0.984" "1.024" "1.042" "1.051" "659.4" "681.7" "656.9" "691.3" "653.0" "704.5" "648.9" "675.1" "687.0" "692.9" "" "" "" "" "" "" "" "" "" "" "617.9" "564.1" "609.8" "534.4" "556.6" "673.1" "592.9" "599.4" "687.0" "667.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3311968132693307525" "False" "High" "IsMasterProtein" "P42773" "Cyclin-dependent kinase 4 inhibitor C OS=Homo sapiens OX=9606 GN=CDKN2C PE=1 SV=1" "0.000" "False" "10.801" "20" "4" "6" "4" "168" "18.1" "6.52" "17.63" "4" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf12796" "1031" "ENSG00000123080" "CDKN2C" "hsa:1031; P42773; Q8TB83" "Cell cycle; Glioblastoma signaling pathways; Vitamin D receptor pathway; G1 to S cell cycle control" "Oxidative Stress Induced Senescence; Oncogene Induced Senescence; Cyclin D associated events in G1; Senescence-Associated Secretory Phenotype (SASP)" "8" "0" "1.000" "0.997" "1.131" "1.047" "1.282" "1.056" "1.043" "1.151" "1.171" "198.5" "198.6" "197.8" "224.5" "207.9" "254.5" "209.6" "207.0" "228.4" "232.4" "" "" "" "" "" "" "" "" "" "" "186.0" "164.3" "183.6" "173.6" "177.2" "243.2" "191.6" "183.8" "228.4" "223.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7857445100061984594" "False" "High" "IsMasterProtein" "Q8WVY7" "Ubiquitin-like domain-containing CTD phosphatase 1 OS=Homo sapiens OX=9606 GN=UBLCP1 PE=1 SV=2" "0.000" "False" "10.801" "14" "5" "7" "5" "318" "36.8" "6.46" "21.27" "5" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00240, Pf03031" "134510" "ENSG00000164332" "UBLCP1" "D3DQJ7; hsa:134510; Q8WVY7; Q96DK5" "" "" "0" "0" "0.987" "1.023" "0.844" "0.891" "0.935" "0.893" "0.970" "0.928" "0.899" "357.5" "353.0" "365.8" "301.6" "318.5" "334.3" "319.4" "346.9" "331.9" "321.3" "" "" "" "" "" "" "" "" "" "" "335.0" "292.1" "339.6" "233.2" "271.5" "319.4" "291.8" "308.0" "331.9" "309.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1047850882453787868" "False" "High" "IsMasterProtein" "Q96S19" "Methyltransferase-like 26 OS=Homo sapiens OX=9606 GN=METTL26 PE=1 SV=2" "0.000" "False" "10.793" "16" "3" "5" "3" "204" "22.6" "7.83" "10.75" "3" "" "" "other molecular function" "Pf06080" "84326" "ENSG00000130731" "METTL26" "A8MTR1; A8MWJ8; A8MZA1; B4DG95; B4DIJ3; D6REA6; F6TF62; F6VM53; hsa:84326; Q96IW1; Q96MD6; Q96S19" "" "" "0" "0" "0.959" "1.004" "1.183" "1.042" "1.032" "1.145" "0.949" "0.932" "1.004" "129.1" "123.8" "129.6" "152.7" "134.5" "133.2" "147.8" "122.5" "120.3" "129.6" "" "" "" "" "" "" "" "" "" "" "121.0" "102.4" "120.3" "118.1" "114.7" "127.3" "135.0" "108.8" "120.3" "124.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4503550903694701286" "False" "High" "IsMasterProtein" "O60504" "Vinexin OS=Homo sapiens OX=9606 GN=SORBS3 PE=1 SV=2" "0.000" "False" "10.791" "6" "4" "4" "4" "671" "75.3" "9.45" "11.97" "4" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00018, Pf02208, Pf14604" "10174" "ENSG00000120896" "SORBS3" "hsa:10174; O60504; Q5BJE4; Q6NX54; Q96FY4; Q9UQE4" "" "Smooth Muscle Contraction" "1" "0" "0.973" "0.995" "0.959" "1.018" "1.064" "0.895" "1.036" "0.972" "0.976" "471.3" "458.4" "468.9" "451.9" "480.0" "501.6" "421.7" "488.1" "458.1" "460.0" "" "" "" "" "" "" "" "" "" "" "441.6" "379.3" "435.3" "349.3" "409.1" "479.2" "385.3" "433.4" "458.1" "442.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4378027519318782833" "False" "High" "IsMasterProtein" "Q9H425" "Uncharacterized protein C1orf198 OS=Homo sapiens OX=9606 GN=C1orf198 PE=1 SV=1" "0.000" "False" "10.772" "9" "3" "3" "3" "327" "36.3" "5.72" "11.14" "3" "" "cytosol" "" "Pf15797" "84886" "ENSG00000119280" "C1orf198" "A8K8R8; B3KTW1; G5EA08; hsa:84886; Q9H425" "" "" "0" "0" "1.072" "0.945" "1.072" "1.089" "1.094" "0.985" "0.973" "0.964" "1.024" "439.0" "470.7" "414.7" "470.5" "477.9" "480.4" "432.3" "427.3" "423.3" "449.6" "" "" "" "" "" "" "" "" "" "" "411.3" "389.5" "385.0" "363.7" "407.4" "459.0" "395.0" "379.4" "423.3" "432.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6200383293614890998" "False" "High" "IsMasterProtein" "Q9UK45" "U6 snRNA-associated Sm-like protein LSm7 OS=Homo sapiens OX=9606 GN=LSM7 PE=1 SV=1" "0.000" "False" "10.771" "47" "4" "9" "4" "103" "11.6" "5.27" "21.98" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "51690" "ENSG00000130332" "LSM7" "hsa:51690; Q9UK45" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "3" "0" "0.995" "0.940" "0.867" "0.919" "0.978" "0.969" "0.995" "0.910" "0.914" "1326.5" "1320.4" "1247.2" "1149.8" "1219.2" "1297.9" "1285.9" "1319.9" "1207.2" "1212.3" "" "" "" "" "" "" "" "" "" "" "1242.9" "1092.6" "1157.8" "888.8" "1039.2" "1240.0" "1174.9" "1172.0" "1207.2" "1167.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6933649257231024003" "False" "High" "IsMasterProtein" "P16930" "Fumarylacetoacetase OS=Homo sapiens OX=9606 GN=FAH PE=1 SV=2" "0.000" "False" "10.768" "7" "3" "4" "3" "419" "46.3" "6.95" "13.85" "3" "other metabolic processes" "cytosol" "other molecular function" "Pf01557, Pf09298" "2184" "ENSG00000103876" "FAH" "B2R9X1; D3DW95; hsa:2184; P16930; Q53XA7" "Amino acid metabolism" "Tyrosine catabolism" "2" "0" "0.875" "0.880" "1.036" "0.782" "1.088" "0.859" "0.889" "0.910" "0.888" "220.9" "193.3" "194.4" "228.9" "172.7" "240.5" "189.8" "196.4" "201.0" "196.1" "" "" "" "" "" "" "" "" "" "" "207.0" "160.0" "180.5" "177.0" "147.2" "229.7" "173.5" "174.4" "201.0" "188.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3906185605223521012" "False" "High" "IsMasterProtein" "Q9BY32" "Inosine triphosphate pyrophosphatase OS=Homo sapiens OX=9606 GN=ITPA PE=1 SV=2" "0.000" "False" "10.767" "20" "3" "3" "3" "194" "21.4" "5.66" "12.65" "3" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01725" "3704" "ENSG00000125877" "ITPA" "A2A2N2; A4UIM5; B2BCH7; hsa:3704; O14878; Q5JWH4; Q9BY32; Q9BYN1; Q9BYX0; Q9H3H8" "" "Purine catabolism; Ribavirin ADME" "2" "0" "0.882" "0.959" "0.897" "1.015" "0.998" "0.887" "0.908" "0.887" "0.975" "109.2" "96.3" "104.8" "98.0" "110.8" "108.9" "96.9" "99.2" "96.9" "106.5" "" "" "" "" "" "" "" "" "" "" "102.3" "79.7" "97.3" "75.7" "94.5" "104.1" "88.5" "88.1" "96.9" "102.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3538958500289371582" "False" "High" "IsMasterProtein" "P49336" "Cyclin-dependent kinase 8 OS=Homo sapiens OX=9606 GN=CDK8 PE=1 SV=1" "0.000" "False" "10.765" "8" "4" "4" "4" "464" "53.3" "8.57" "13.96" "4" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1024" "ENSG00000132964" "CDK8" "hsa:1024; P49336; Q5VUF3; Q6ISB5" "Sterol regulatory element-binding proteins (SREBP) signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; lncRNA in canonical Wnt signaling and colorectal cancer" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH1 Intracellular Domain Regulates Transcription" "11" "0" "0.945" "1.021" "1.049" "1.057" "1.068" "1.043" "1.050" "1.007" "1.113" "848.6" "801.8" "866.4" "890.0" "896.6" "906.0" "885.5" "891.4" "854.8" "944.8" "" "" "" "" "" "" "" "" "" "" "795.1" "663.5" "804.3" "688.0" "764.2" "865.6" "809.1" "791.5" "854.8" "909.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8446655200423982377" "False" "High" "IsMasterProtein" "Q8N4C8" "Misshapen-like kinase 1 OS=Homo sapiens OX=9606 GN=MINK1 PE=1 SV=2" "0.000" "False" "10.752" "3" "4" "5" "1" "1332" "149.7" "7.85" "13.85" "4" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00780" "50488" "ENSG00000141503" "MINK1" "D3DTK3; D3DTK4; hsa:50488; Q5U8Z0; Q8N4C8; Q9P1X1; Q9P2R8" "Angiopoietin-like protein 8 regulatory pathway; Hippo-YAP signaling; Insulin signaling; Pleural mesothelioma" "Oxidative Stress Induced Senescence" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1829057595259192676" "False" "High" "IsMasterProtein" "Q8ND83" "SLAIN motif-containing protein 1 OS=Homo sapiens OX=9606 GN=SLAIN1 PE=1 SV=3" "0.000" "False" "10.744" "6" "4" "7" "3" "568" "60.6" "7.64" "23.27" "4" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf15301" "122060" "ENSG00000139737" "SLAIN1" "A8K0Z9; B7Z209; hsa:122060; Q5T6P4; Q5T6P7; Q8ND10; Q8ND83; Q96NV0" "" "" "0" "0" "1.073" "1.008" "1.030" "1.033" "1.068" "0.996" "0.920" "1.066" "1.080" "464.3" "498.3" "468.1" "478.2" "479.5" "496.0" "462.6" "427.3" "495.0" "501.3" "" "" "" "" "" "" "" "" "" "" "435.0" "412.4" "434.6" "369.7" "408.7" "473.9" "422.7" "379.4" "495.0" "482.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2811678325838740313" "False" "High" "IsMasterProtein" "Q9NXW9" "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 OS=Homo sapiens OX=9606 GN=ALKBH4 PE=1 SV=1" "0.000" "False" "10.740" "9" "3" "4" "3" "302" "33.8" "6.67" "14.14" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "54784" "ENSG00000160993" "ALKBH4" "hsa:54784; Q53H92; Q9H6A4; Q9NXW9" "" "" "0" "0" "0.968" "0.965" "1.098" "0.983" "1.025" "0.968" "0.897" "0.899" "0.932" "406.8" "393.9" "392.5" "446.6" "399.9" "417.1" "393.6" "364.7" "365.6" "379.2" "" "" "" "" "" "" "" "" "" "" "381.2" "326.0" "364.3" "345.2" "340.9" "398.5" "359.7" "323.9" "365.6" "365.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6802815428408388451" "False" "High" "IsMasterProtein" "Q9UK99" "F-box only protein 3 OS=Homo sapiens OX=9606 GN=FBXO3 PE=1 SV=3" "0.000" "False" "10.728" "8" "3" "4" "3" "471" "54.5" "5.00" "12.74" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00646, Pf04379, Pf09346" "26273" "ENSG00000110429" "FBXO3" "B3KY16; D3DR05; hsa:26273; Q86X90; Q9H0V2; Q9NUX2; Q9UK99" "" "" "0" "0" "0.956" "1.045" "1.113" "1.263" "0.964" "1.059" "0.906" "0.987" "1.144" "81.5" "78.0" "85.2" "90.8" "103.0" "78.6" "86.4" "73.9" "80.5" "93.3" "" "" "" "" "" "" "" "" "" "" "76.4" "64.5" "79.1" "70.2" "87.8" "75.1" "78.9" "65.6" "80.5" "89.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6043463436452304537" "False" "High" "IsMasterProtein" "Q5SSJ5" "Heterochromatin protein 1-binding protein 3 OS=Homo sapiens OX=9606 GN=HP1BP3 PE=1 SV=1" "0.000" "False" "10.722" "8" "5" "6" "5" "553" "61.2" "9.67" "13.05" "5" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "50809" "ENSG00000127483" "HP1BP3" "A6NI71; A8K5D7; B3KMZ8; B4E210; hsa:50809; Q05BI0; Q5SSJ5; Q5SSJ6; Q5SWC6; Q6PIM9; Q8NDF0; Q9UHY0" "" "" "0" "0" "1.048" "0.966" "0.885" "0.970" "0.998" "1.013" "0.908" "0.966" "0.950" "458.1" "480.2" "442.4" "405.2" "444.3" "457.0" "464.0" "415.8" "442.3" "435.4" "" "" "" "" "" "" "" "" "" "" "429.2" "397.4" "410.8" "313.3" "378.7" "436.6" "424.0" "369.2" "442.3" "419.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6660198099631122457" "False" "High" "IsMasterProtein" "Q7Z3B3" "KAT8 regulatory NSL complex subunit 1 OS=Homo sapiens OX=9606 GN=KANSL1 PE=1 SV=3" "0.000" "False" "10.721" "3" "4" "4" "4" "1105" "120.9" "8.75" "11.79" "4" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15275" "284058" "ENSG00000120071" "KANSL1" "A8K5E4; B3KT49; hsa:284058; I3L4J3; Q6AW85; Q7Z3B3; Q8IYH1; Q9BRH0; Q9NTE7; Q9UFT0; Q9ULF3" "Pathways affected in adenoid cystic carcinoma" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "3" "0" "1.129" "1.013" "1.229" "1.063" "1.074" "1.130" "1.005" "0.991" "1.058" "386.2" "436.1" "391.2" "474.8" "410.7" "414.8" "436.3" "388.3" "382.6" "408.6" "" "" "" "" "" "" "" "" "" "" "361.8" "360.8" "363.1" "367.0" "350.1" "396.3" "398.6" "344.7" "382.6" "393.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1716870644817082742" "False" "High" "IsMasterProtein" "Q15751" "Probable E3 ubiquitin-protein ligase HERC1 OS=Homo sapiens OX=9606 GN=HERC1 PE=1 SV=2" "0.000" "False" "10.713" "1" "3" "3" "3" "4861" "531.9" "6.04" "9.69" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf00415, Pf00622, Pf00632" "8925" "ENSG00000103657" "HERC1" "hsa:8925; Q15751; Q8IW65" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.982" "1.038" "1.081" "1.021" "1.005" "1.039" "0.987" "0.985" "1.037" "397.5" "390.4" "412.5" "429.6" "405.7" "399.6" "412.8" "392.4" "391.6" "412.1" "" "" "" "" "" "" "" "" "" "" "372.5" "323.0" "382.9" "332.1" "345.8" "381.7" "377.2" "348.4" "391.6" "396.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1698124095596496194" "False" "High" "IsMasterProtein" "Q14147" "Probable ATP-dependent RNA helicase DHX34 OS=Homo sapiens OX=9606 GN=DHX34 PE=1 SV=2" "0.000" "False" "10.712" "3" "4" "4" "4" "1143" "128.0" "7.56" "12.12" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "9704" "ENSG00000134815" "DHX34" "B4DMY8; hsa:9704; Q14147" "" "" "0" "0" "1.095" "0.998" "1.164" "1.072" "0.969" "1.073" "1.107" "0.965" "1.045" "155.2" "170.0" "154.8" "180.6" "166.3" "150.5" "166.5" "171.8" "149.7" "162.2" "" "" "" "" "" "" "" "" "" "" "145.4" "140.7" "143.7" "139.6" "141.8" "143.7" "152.1" "152.6" "149.7" "156.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7472508916157269106" "False" "High" "IsMasterProtein" "Q9H9P8" "L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=L2HGDH PE=1 SV=3" "0.000" "False" "10.710" "8" "3" "3" "3" "463" "50.3" "8.15" "12.86" "3" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf01266" "79944" "ENSG00000087299" "L2HGDH" "hsa:79944; Q9BRR1; Q9H9P8" "Cerebral organic acidurias, including diseases" "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" "2" "0" "0.979" "0.954" "0.923" "0.960" "0.874" "0.831" "0.844" "0.873" "0.906" "782.2" "765.6" "746.6" "722.1" "750.6" "683.3" "650.1" "660.1" "683.0" "709.0" "" "" "" "" "" "" "" "" "" "" "732.9" "633.5" "693.1" "558.2" "639.8" "652.8" "594.0" "586.1" "683.0" "682.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8333462526308289964" "False" "High" "IsMasterProtein" "O60671" "Cell cycle checkpoint protein RAD1 OS=Homo sapiens OX=9606 GN=RAD1 PE=1 SV=1" "0.000" "False" "10.710" "11" "4" "5" "4" "282" "31.8" "4.83" "16.97" "4" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02144" "5810" "ENSG00000113456" "RAD1" "hsa:5810; O60671; O75572; O95304; Q1W161; Q5KSM0; Q5KSM1; Q9UEP1" "miRNA regulation of DNA damage response; ATR signaling; DNA damage response" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "10" "0" "0.934" "1.034" "1.073" "1.057" "0.968" "1.012" "0.985" "1.038" "1.058" "975.9" "911.9" "1008.8" "1047.5" "1031.8" "944.7" "987.8" "961.3" "1012.5" "1032.3" "" "" "" "" "" "" "" "" "" "" "914.4" "754.6" "936.6" "809.8" "879.5" "902.6" "902.5" "853.6" "1012.5" "993.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5615919369887998349" "False" "High" "IsMasterProtein" "P49903" "Selenide, water dikinase 1 OS=Homo sapiens OX=9606 GN=SEPHS1 PE=1 SV=2" "0.000" "False" "10.703" "12" "4" "5" "3" "392" "42.9" "5.97" "17.77" "4" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf00586, Pf02769" "22929" "ENSG00000086475" "SEPHS1" "B4DWK0; D3DRS9; D6PSQ9; hsa:22929; P49903; Q5T5U8; Q5T5U9; Q9BVT4" "" "" "0" "0" "0.944" "1.050" "0.951" "1.136" "1.091" "1.013" "1.022" "1.171" "1.160" "142.4" "134.4" "149.6" "135.4" "161.7" "155.3" "144.2" "145.5" "166.7" "165.2" "" "" "" "" "" "" "" "" "" "" "133.4" "111.2" "138.8" "104.7" "137.8" "148.4" "131.8" "129.2" "166.7" "159.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2830448209821531490" "False" "High" "IsMasterProtein" "Q9GZS3" "Superkiller complex protein 8 OS=Homo sapiens OX=9606 GN=SKIC8 PE=1 SV=1" "0.000" "False" "10.702" "11" "3" "5" "3" "305" "33.6" "5.47" "14.38" "3" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "80349" "ENSG00000140395" "SKIC8" "D3DW84; hsa:80349; Q6IA22; Q7Z4X4; Q9GZS3" "" "RNA Polymerase II Pre-transcription Events; mRNA decay by 3' to 5' exoribonuclease; E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex" "5" "0" "0.925" "1.043" "1.064" "1.015" "1.006" "1.062" "1.061" "0.938" "1.019" "291.0" "269.1" "303.6" "309.5" "295.3" "292.6" "309.0" "308.7" "272.8" "296.4" "" "" "" "" "" "" "" "" "" "" "272.6" "222.7" "281.9" "239.2" "251.7" "279.5" "282.4" "274.1" "272.8" "285.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7283076570857654598" "False" "High" "IsMasterProtein" "Q96F44" "E3 ubiquitin-protein ligase TRIM11 OS=Homo sapiens OX=9606 GN=TRIM11 PE=1 SV=2" "0.000" "False" "10.695" "11" "4" "5" "4" "468" "52.7" "5.69" "12.32" "4" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13765, Pf15227" "81559" "ENSG00000154370" "TRIM11" "A6NKE2; B2RB82; B3KUS3; B4DX88; hsa:81559; Q5VSU1; Q8NCA6; Q96F44; Q9C022" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.974" "1.014" "1.084" "1.046" "1.063" "1.023" "1.051" "1.012" "1.034" "548.4" "533.9" "556.3" "594.8" "573.8" "582.8" "561.1" "576.5" "555.1" "567.1" "" "" "" "" "" "" "" "" "" "" "513.9" "441.8" "516.5" "459.8" "489.1" "556.8" "512.7" "511.9" "555.1" "546.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5200285318932313306" "False" "High" "IsMasterProtein" "Q9UHR6" "Zinc finger HIT domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZNHIT2 PE=1 SV=1" "0.000" "False" "10.694" "9" "4" "5" "4" "403" "42.9" "5.99" "10.85" "4" "" "" "other molecular function" "Pf04438" "741" "ENSG00000174276" "ZNHIT2" "hsa:741; Q3SY14; Q8IUV0; Q9UHR6" "" "" "0" "0" "1.114" "0.967" "1.041" "1.051" "1.029" "0.949" "0.930" "0.953" "1.005" "316.3" "352.3" "306.0" "329.2" "332.5" "325.5" "300.2" "294.1" "301.4" "317.9" "" "" "" "" "" "" "" "" "" "" "296.4" "291.5" "284.1" "254.5" "283.4" "311.0" "274.3" "261.2" "301.4" "306.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2002509444900540538" "False" "High" "IsMasterProtein" "Q9BTY2" "Plasma alpha-L-fucosidase OS=Homo sapiens OX=9606 GN=FUCA2 PE=1 SV=2" "0.000" "False" "10.688" "7" "4" "4" "4" "467" "54.0" "6.25" "11.71" "4" "other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf01120, Pf16757" "2519" "ENSG00000001036" "FUCA2" "E9PEB6; hsa:2519; Q7Z6V1; Q7Z6Y2; Q8NBK4; Q9BTY2" "" "Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "3" "0" "0.916" "0.926" "0.954" "0.957" "0.978" "0.869" "0.913" "0.902" "0.992" "346.0" "317.1" "320.4" "330.0" "331.1" "338.3" "300.7" "315.7" "311.9" "343.1" "" "" "" "" "" "" "" "" "" "" "324.2" "262.4" "297.5" "255.1" "282.2" "323.2" "274.8" "280.3" "311.9" "330.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1015618648752571383" "False" "High" "IsMasterProtein" "P55210" "Caspase-7 OS=Homo sapiens OX=9606 GN=CASP7 PE=1 SV=1" "0.000" "False" "10.679" "14" "4" "4" "4" "303" "34.3" "6.07" "11.32" "4" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00656" "840" "ENSG00000165806" "CASP7" "B4DQU7; B5BU45; D3DRB8; hsa:840; P55210; Q13364; Q53YD5; Q5SVL0; Q5SVL3; Q96BA0" "Nucleotide-binding oligomerization domain (NOD) pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Allograft rejection; Parkinson's disease pathway; Oncostatin M signaling pathway; Nanomaterial induced apoptosis; Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; RAC1/PAK1/p38/MMP2 pathway; Hepatitis C and hepatocellular carcinoma; Apoptosis modulation by HSP70; ERK pathway in Huntington's disease; Acute viral myocarditis; Nonalcoholic fatty liver disease; Host-pathogen interaction of human coronaviruses - apoptosis; 3q29 copy number variation syndrome; Complement system in neuronal development and plasticity; Alzheimer's disease" "Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Caspase-mediated cleavage of cytoskeletal proteins" "27" "0" "1.165" "1.107" "1.163" "1.197" "1.093" "1.015" "1.022" "1.072" "1.104" "332.5" "387.4" "368.1" "386.6" "397.9" "363.3" "337.4" "339.7" "356.4" "366.9" "" "" "" "" "" "" "" "" "" "" "311.5" "320.6" "341.7" "298.8" "339.2" "347.1" "308.3" "301.6" "356.4" "353.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4440624783436864340" "False" "High" "IsMasterProtein" "P01911" "HLA class II histocompatibility antigen, DRB1 beta chain OS=Homo sapiens OX=9606 GN=HLA-DRB1 PE=1 SV=2" "0.000" "False" "10.668" "13" "3" "3" "1" "266" "29.9" "7.74" "11.59" "3" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00969, Pf07654" "3123" "ENSG00000196126" "HLA-DRB1" "A0MWF2; A0N0W1; A2ICT1; A2TGX3; A4F5N0; A4ZXA5; A4ZXA6; A4ZY86; A5H000; A5HKN8; A7DZP9; A7LA26; A7UHG2; A7X5B1; A7X5B7; A7X5E0; A7X5E6; A7X5H8; A7X5J4; A7X5K7; A8K098; A8YQE9; A9JPG0; B0BK85; B0LUZ6; B0UYW1; B1GWE7; B2CR03; B2LVF9; B2NJ29; B2ZCY1; B3VTP8; B3VTQ3; B5A8Y2; B5A8Y3; B5B8U0; B5B9V5; B5B9V6; B5LZ25; B5QSK8; B6VCX2; B6VEL9; B7UDB2; B9VRA4; B9X248; C0LAB5; hsa:3123; O02876; O02930; O19585; O19717; O19718; O19739; O19788; O46699; O46793; O46872; O62869; O62889; O77969; O78047; O78210; O98212; P01911; P01912; P01914; P04229; P13758; P13759; P13760; P13761; P20039; P79545; Q06662; Q0PGR5; Q0PQ39; Q14280; Q14QT2; Q155F7; Q19AF2; Q19K86; Q1AP33; Q1G0Z9; Q1JRP3; Q1KLJ6; Q27PR6; Q27PR7; Q29673; Q29720; Q29722; Q29734; Q29770; Q29771; Q29772; Q29790; Q29792; Q29800; Q29806; Q29833; Q29874; Q29875; Q29886; Q29968; Q29974; Q29975; Q2A120; Q2HZE5; Q2L9H4; Q2LE76; Q2MF40; Q2MJA6; Q2MZ92; Q2VQU1; Q2YHQ2; Q30006; Q30108; Q30112; Q30115; Q30116; Q30117; Q30120; Q30134; Q30142; Q30145; Q30149; Q30159; Q30166; Q30167; Q30200; Q307W5; Q31636; Q32MY7; Q3HUP9; Q3KTM1; Q3LA84; Q3LA87; Q3LA88; Q3LA89; Q3LA90; Q3LA91; Q3LA92; Q3LA93; Q3LA94; Q3LA95; Q3LA96; Q3LA97; Q3LA98; Q3LA99; Q3LAA0; Q3LAA1; Q3LAA2; Q3MQ60; Q3T919; Q4PRC3; Q4PRC5; Q4VZY7; Q53IG1; Q56FN9; Q56FP1; Q56FP2; Q56FP3; Q58F52; Q5BM92; Q5EER6; Q5K3W2; Q5NDB9; Q5U9W6; Q5UBA2; Q5UT58; Q5W3L4; Q5Y7A7; Q5Y7B0; Q5Y7B9; Q5Y7E9; Q5Y7G0; Q683P7; Q6REE2; Q6T865; Q6U387; Q701T1; Q70GL2; Q70Q85; Q768U2; Q768U4; Q7M2H4; Q7YNY9; Q7YP03; Q7YP04; Q7YQ26; Q7YQA3; Q7YQA5; Q860D8; Q860D9; Q860E5; Q860H8; Q860S0; Q860Z3; Q861G6; Q861H0; Q861H4; Q861H5; Q861H7; Q861H8; Q8HWQ6; Q8MH59; Q8MH60; Q8WLU3; Q8WMA0; Q95348; Q95383; Q95389; Q95461; Q95HK1; Q95HL0; Q95HL1; Q95IE3; Q95IG2; Q95IT6; Q96HZ9; Q9BCL7; Q9BCP0; Q9BCP1; Q9BCP2; Q9BCP5; Q9BD21; Q9BD33; Q9BD40; Q9GIK5; Q9GIL5; Q9GIL6; Q9GIP3; Q9GIX8; Q9GIX9; Q9GIY0; Q9GIY1; Q9GIY2; Q9GIY3; Q9GIY4; Q9GJ25; Q9GJ56; Q9GJ57; Q9GJ58; Q9GJ60; Q9GJF8; Q9GJF9; Q9GJG0; Q9MXZ0; Q9MXZ5; Q9MY13; Q9MY45; Q9MY56; Q9MYF5; Q9TPB6; Q9TPW1; Q9TPW3; Q9TPW9; Q9TPX4; Q9TQ37; Q9TQ91; Q9TQE0; Q9UBY1; Q9UIM9; Q9UIN0; Q9XRX1; Q9XRY4; Q9XRY5; Q9Y453; Q9Y4H7" "Allograft rejection; Vitamin D receptor pathway; Ebola virus infection in host; Cancer immunotherapy by PD-1 blockade; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Genes associated with the development of rheumatoid arthritis; Network map of SARS-CoV-2 signaling pathway; Cell interactions of the pancreatic cancer microenvironment; Cytokines and inflammatory response; Primary ovarian insufficiency" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "17" "0" "1.072" "0.944" "1.005" "1.012" "0.994" "0.920" "0.982" "0.999" "0.940" "253.9" "272.1" "239.6" "255.1" "257.0" "252.4" "233.5" "249.2" "253.7" "238.8" "" "" "" "" "" "" "" "" "" "" "237.9" "225.2" "222.4" "197.2" "219.1" "241.2" "213.3" "221.3" "253.7" "229.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5223570774126061662" "False" "High" "IsMasterProtein" "Q9UKA4" "A-kinase anchor protein 11 OS=Homo sapiens OX=9606 GN=AKAP11 PE=1 SV=1" "0.000" "False" "10.667" "2" "4" "5" "4" "1901" "210.4" "5.39" "15.08" "4" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "11215" "ENSG00000023516" "AKAP11" "hsa:11215; O75124; Q9NUK7; Q9UKA4" "G protein signaling pathways" "" "1" "0" "1.034" "0.990" "1.120" "1.046" "1.016" "1.007" "0.979" "1.006" "1.005" "504.5" "521.8" "499.3" "564.9" "527.5" "512.7" "508.3" "494.1" "507.7" "507.2" "" "" "" "" "" "" "" "" "" "" "472.7" "431.8" "463.6" "436.7" "449.6" "489.8" "464.4" "438.7" "507.7" "488.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4996953049836216410" "False" "High" "IsMasterProtein" "O14618" "Copper chaperone for superoxide dismutase OS=Homo sapiens OX=9606 GN=CCS PE=1 SV=1" "0.000" "False" "10.667" "14" "4" "4" "4" "274" "29.0" "5.58" "12.55" "4" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00080, Pf00403" "9973" "ENSG00000173992" "CCS" "hsa:9973; O14618; Q2M366; Q8NEV0" "Amyotrophic lateral sclerosis (ALS); Copper homeostasis" "Detoxification of Reactive Oxygen Species" "3" "0" "1.054" "0.976" "1.035" "1.095" "1.023" "1.050" "1.045" "1.054" "1.036" "486.8" "513.1" "475.1" "503.8" "533.2" "497.8" "510.9" "508.5" "513.1" "504.5" "" "" "" "" "" "" "" "" "" "" "456.1" "424.6" "441.1" "389.5" "454.5" "475.6" "466.8" "451.5" "513.1" "485.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3995888645862527253" "False" "High" "IsMasterProtein" "A4D1E9" "GTP-binding protein 10 OS=Homo sapiens OX=9606 GN=GTPBP10 PE=1 SV=1" "0.000" "False" "10.659" "10" "4" "5" "4" "387" "42.9" "9.03" "9.11" "4" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf01018, Pf01926" "85865" "ENSG00000105793" "GTPBP10" "A4D1E9; B4DFY6; hsa:85865; Q3B7A6; Q5H9V2; Q8IXG8; Q8N982; Q8WU16; Q9BSP1; Q9Y6T6" "" "" "0" "0" "0.997" "1.047" "1.003" "1.071" "1.028" "1.069" "1.044" "1.077" "1.048" "383.8" "382.5" "401.9" "384.9" "410.9" "394.7" "410.4" "400.8" "413.6" "402.1" "" "" "" "" "" "" "" "" "" "" "359.7" "316.5" "373.1" "297.6" "350.3" "377.1" "375.0" "355.9" "413.6" "387.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1984767701943514611" "False" "High" "IsMasterProtein" "Q9NQS1" "Cell death regulator Aven OS=Homo sapiens OX=9606 GN=AVEN PE=1 SV=1" "0.000" "False" "10.643" "12" "4" "4" "4" "362" "38.5" "4.98" "14.09" "4" "other biological processes" "other membranes;cytosol;other cell component" "" "" "57099" "ENSG00000169857" "AVEN" "hsa:57099; Q9NQS1" "" "Regulation of the apoptosome activity" "2" "0" "1.060" "0.980" "1.048" "1.050" "1.144" "1.122" "1.035" "1.072" "1.120" "388.7" "412.1" "380.8" "407.4" "408.2" "444.5" "436.3" "402.3" "416.6" "435.1" "" "" "" "" "" "" "" "" "" "" "364.2" "341.0" "353.5" "315.0" "347.9" "424.7" "398.6" "357.2" "416.6" "419.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5959854138225624200" "False" "High" "IsMasterProtein" "Q7Z6E9" "E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens OX=9606 GN=RBBP6 PE=1 SV=1" "0.000" "False" "10.642" "2" "4" "4" "4" "1792" "201.4" "9.64" "8.37" "4" "protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04564, Pf08783, Pf13696" "5930" "ENSG00000122257" "RBBP6" "Q147T5; Q15290; Q6DKH4; Q6P4C2; Q6YNC9; Q7Z6E8; Q7Z6E9; Q8N0V2; Q96PH3; Q9H3I8; Q9H5M5; Q9NPX4" "" "RHOBTB1 GTPase cycle; Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.080" "1.103" "1.198" "1.095" "1.066" "1.209" "1.204" "1.232" "1.143" "195.1" "210.7" "215.2" "233.6" "213.5" "208.0" "235.8" "234.8" "240.3" "222.9" "" "" "" "" "" "" "" "" "" "" "182.8" "174.3" "199.8" "180.6" "182.0" "198.7" "215.4" "208.5" "240.3" "214.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8135385361793162553" "False" "High" "IsMasterProtein" "Q9BQA1" "Methylosome protein WDR77 OS=Homo sapiens OX=9606 GN=WDR77 PE=1 SV=1" "0.000" "False" "10.639" "10" "3" "5" "3" "342" "36.7" "5.17" "12.79" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "79084" "ENSG00000116455" "WDR77" "B3KMW6; B4DP38; hsa:79084; Q3LID2; Q53FU2; Q6JZZ5; Q96GK4; Q9BQA1; Q9BWY3" "" "RMTs methylate histone arginines; snRNP Assembly" "2" "0" "1.081" "1.048" "1.187" "1.030" "1.028" "1.085" "1.066" "1.067" "1.090" "442.1" "478.0" "463.5" "525.0" "455.4" "454.3" "479.8" "471.4" "471.6" "481.9" "" "" "" "" "" "" "" "" "" "" "414.3" "395.6" "430.3" "405.9" "388.1" "434.0" "438.4" "418.6" "471.6" "464.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3294406842495901290" "False" "High" "IsMasterProtein" "Q8NHM5" "Lysine-specific demethylase 2B OS=Homo sapiens OX=9606 GN=KDM2B PE=1 SV=1" "0.000" "False" "10.635" "3" "4" "4" "4" "1336" "152.5" "8.56" "6.55" "4" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02008, Pf12937, Pf13621, Pf16866, Pf17811" "84678" "ENSG00000089094" "KDM2B" "A8MRS1; hsa:84678; Q1RLM7; Q8NCI2; Q8NHM5; Q96HC7; Q96SL0; Q96T03; Q9NS96; Q9UF75" "FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "HDMs demethylate histones" "2" "0" "1.120" "0.973" "1.348" "1.104" "1.062" "1.208" "1.040" "1.033" "1.087" "137.4" "153.9" "133.7" "185.3" "151.7" "145.9" "166.0" "142.9" "142.0" "149.4" "" "" "" "" "" "" "" "" "" "" "128.8" "127.4" "124.2" "143.3" "129.3" "139.4" "151.7" "126.9" "142.0" "143.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "584714024089658403" "False" "High" "IsMasterProtein" "Q5XPI4" "E3 ubiquitin-protein ligase RNF123 OS=Homo sapiens OX=9606 GN=RNF123 PE=1 SV=1" "0.000" "False" "10.627" "3" "5" "6" "3" "1314" "148.4" "6.74" "13.75" "5" "protein metabolism;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf13920" "63891" "ENSG00000164068" "RNF123" "A1L4Q3; A6NLS5; hsa:63891; Q5I022; Q5XPI4; Q6PFW4; Q71RH0; Q8IW18; Q9H0M8; Q9H5L8; Q9H9T2" "" "Ub-specific processing proteases; Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.044" "0.905" "1.048" "1.013" "0.992" "0.953" "1.027" "0.904" "1.047" "201.1" "209.8" "182.0" "210.7" "203.6" "199.4" "191.6" "206.4" "181.7" "210.5" "" "" "" "" "" "" "" "" "" "" "188.4" "173.6" "169.0" "162.8" "173.6" "190.5" "175.0" "183.3" "181.7" "202.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3953931010856732739" "False" "High" "IsMasterProtein" "P16104" "Histone H2AX OS=Homo sapiens OX=9606 GN=H2AX PE=1 SV=2" "0.000" "False" "10.605" "22" "4" "6" "1" "143" "15.1" "10.74" "17.11" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "3014" "ENSG00000188486" "H2AX" "hsa:3014; P16104; Q4ZGJ7; Q6IAS5" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Proteasome degradation; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; DNA repair pathways, full network; 5q35 copy number variation; DNA damage response" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; RMTs methylate histone arginines; Amyloid fiber formation; Meiotic synapsis; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; Nonhomologous End-Joining (NHEJ); RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "47" "3" "1.071" "1.046" "1.125" "1.038" "1.025" "0.982" "1.010" "0.960" "0.973" "1136.6" "1216.9" "1188.8" "1278.9" "1179.5" "1164.8" "1116.7" "1147.7" "1091.4" "1106.2" "" "" "" "" "" "" "" "" "" "" "1065.0" "1006.9" "1103.6" "988.7" "1005.4" "1112.8" "1020.3" "1019.1" "1091.4" "1065.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7515623990102163669" "False" "High" "IsMasterProtein" "P51161" "Gastrotropin OS=Homo sapiens OX=9606 GN=FABP6 PE=1 SV=2" "0.000" "False" "10.602" "34" "4" "4" "4" "128" "14.4" "6.80" "11.84" "4" "other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf14651" "2172" "ENSG00000170231" "FABP6" "hsa:2172; P51161; Q07DR7; Q8TBI3; Q9UGI7" "PPAR signaling pathway; Fatty acid transporters" "Triglyceride catabolism; Recycling of bile acids and salts; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis" "5" "0" "0.988" "0.951" "0.925" "0.990" "1.008" "0.942" "0.976" "0.926" "0.995" "685.7" "677.5" "652.4" "634.2" "678.6" "691.5" "646.1" "669.0" "635.3" "682.1" "" "" "" "" "" "" "" "" "" "" "642.5" "560.6" "605.7" "490.2" "578.4" "660.7" "590.4" "594.0" "635.3" "656.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3472433998448837783" "False" "High" "IsMasterProtein" "O75323" "Protein NipSnap homolog 2 OS=Homo sapiens OX=9606 GN=NIPSNAP2 PE=1 SV=1" "0.000" "False" "10.598" "13" "4" "5" "3" "286" "33.7" "9.36" "16.55" "4" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;mitochondrion" "" "Pf07978" "2631" "ENSG00000146729" "NIPSNAP2" "C9IYJ3; hsa:2631; O43801; O75323; Q53X96" "" "RHOJ GTPase cycle; RHOH GTPase cycle" "2" "1" "0.874" "1.063" "0.812" "0.988" "1.044" "0.886" "1.027" "0.997" "0.932" "606.6" "530.2" "644.9" "492.5" "599.1" "633.1" "537.4" "622.7" "604.7" "565.4" "" "" "" "" "" "" "" "" "" "" "568.4" "438.7" "598.7" "380.7" "510.6" "604.9" "491.0" "552.9" "604.7" "544.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8213729863308039280" "False" "High" "IsMasterProtein" "Q14331" "Protein FRG1 OS=Homo sapiens OX=9606 GN=FRG1 PE=1 SV=1" "0.000" "False" "10.586" "13" "3" "5" "3" "258" "29.2" "9.01" "12.74" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "cytoskeletal activity" "Pf06229" "2483" "ENSG00000109536; ENSG00000275145; ENSG00000283153; ENSG00000283630" "FRG1" "A8K775; hsa:2483; Q14331" "" "" "0" "0" "0.938" "1.082" "0.973" "0.978" "0.976" "0.924" "0.988" "0.913" "0.934" "565.9" "530.9" "612.1" "550.5" "553.6" "552.1" "522.9" "559.0" "516.8" "528.3" "" "" "" "" "" "" "" "" "" "" "530.2" "439.3" "568.2" "425.6" "471.8" "527.5" "477.8" "496.3" "516.8" "508.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1347928425928225454" "False" "High" "IsMasterProtein" "O60925" "Prefoldin subunit 1 OS=Homo sapiens OX=9606 GN=PFDN1 PE=1 SV=2" "0.000" "False" "10.566" "27" "4" "6" "4" "122" "14.2" "6.81" "17.25" "4" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "5201" "ENSG00000113068" "PFDN1" "B2RD02; hsa:5201; O60925; Q53F95; Q96EX6" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "1.030" "0.963" "0.949" "0.974" "0.956" "0.996" "0.960" "0.930" "0.917" "1058.4" "1090.7" "1019.0" "1004.9" "1030.7" "1011.9" "1054.4" "1015.6" "984.8" "970.7" "" "" "" "" "" "" "" "" "" "" "991.8" "902.6" "946.0" "776.8" "878.6" "966.8" "963.4" "901.7" "984.8" "934.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7722178459817833286" "False" "High" "IsMasterProtein" "P61970" "Nuclear transport factor 2 OS=Homo sapiens OX=9606 GN=NUTF2 PE=1 SV=1" "0.000" "False" "10.565" "30" "3" "8" "3" "127" "14.5" "5.38" "23.10" "3" "transport;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf02136" "10204" "ENSG00000102898" "NUTF2" "B2R4G7; hsa:10204; P13662; P61970; Q6IB67" "" "" "0" "0" "1.016" "1.063" "1.043" "0.995" "1.020" "0.977" "1.092" "1.075" "1.017" "858.8" "872.2" "912.9" "895.7" "854.8" "876.1" "839.3" "937.7" "922.9" "873.2" "" "" "" "" "" "" "" "" "" "" "804.7" "721.7" "847.5" "692.4" "728.6" "837.0" "766.9" "832.6" "922.9" "840.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4125655909395712746" "False" "High" "IsMasterProtein" "Q8IUR7" "Armadillo repeat-containing protein 8 OS=Homo sapiens OX=9606 GN=ARMC8 PE=1 SV=2" "0.000" "False" "10.555" "6" "4" "5" "4" "673" "75.5" "6.73" "16.54" "4" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00514" "25852" "ENSG00000114098" "ARMC8" "A8K0L2; B7Z441; B7Z453; D3DNE6; F5GWK4; hsa:25852; Q6PIL2; Q8IUR7; Q96D19; Q96HZ5; Q9NV02; Q9NV94; Q9Y4R9" "Ciliary landscape" "Neutrophil degranulation" "2" "0" "0.998" "1.072" "1.059" "1.035" "1.086" "0.944" "0.982" "1.126" "1.059" "284.3" "283.6" "304.8" "301.1" "294.4" "308.7" "268.4" "279.2" "320.1" "301.1" "" "" "" "" "" "" "" "" "" "" "266.4" "234.7" "283.0" "232.8" "250.9" "294.9" "245.3" "247.9" "320.1" "289.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5356440792729817096" "False" "High" "IsMasterProtein" "Q5VZ89" "DENN domain-containing protein 4C OS=Homo sapiens OX=9606 GN=DENND4C PE=1 SV=3" "0.000" "False" "10.549" "3" "4" "4" "4" "1909" "212.6" "6.83" "11.70" "4" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity" "Pf02141, Pf03455, Pf03456" "55667" "ENSG00000137145" "DENND4C" "A2A3R1; A2A3R2; A2A3R3; A2A3R9; hsa:55667; Q5VZ89; Q6AI48; Q6ZUB3; Q8NCY7; Q9H6N4; Q9NUT1; Q9NWA5; Q9NWT3; R4GN35; R4GNB2" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.258" "1.251" "1.312" "1.359" "1.216" "1.366" "1.208" "1.144" "1.212" "43.4" "54.6" "54.3" "57.0" "59.0" "52.8" "59.3" "52.5" "49.7" "52.6" "" "" "" "" "" "" "" "" "" "" "40.7" "45.2" "50.4" "44.1" "50.3" "50.4" "54.2" "46.6" "49.7" "50.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2332565569261485395" "False" "High" "IsMasterProtein" "Q9BZL6" "Serine/threonine-protein kinase D2 OS=Homo sapiens OX=9606 GN=PRKD2 PE=1 SV=3" "0.000" "False" "10.542" "5" "3" "4" "3" "878" "96.7" "6.84" "12.09" "3" "cell adhesion;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf00169" "25865" "ENSG00000105287" "PRKD2" "B4DTS2; hsa:25865; M0QZW1; M0R2R2; Q8NCK8; Q8TB08; Q9BZL6; Q9P0T6; Q9Y3X8" "VEGFA-VEGFR2 signaling; Gastrin signaling pathway" "Sphingolipid de novo biosynthesis" "3" "0" "0.997" "0.913" "1.140" "1.122" "0.988" "1.112" "0.921" "0.979" "1.028" "76.9" "76.7" "70.3" "87.7" "86.3" "76.0" "85.6" "70.8" "75.3" "79.1" "" "" "" "" "" "" "" "" "" "" "72.1" "63.5" "65.2" "67.8" "73.6" "72.6" "78.2" "62.9" "75.3" "76.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6342560622817440014" "False" "High" "IsMasterProtein" "Q96PU8" "KH domain-containing RNA-binding protein QKI OS=Homo sapiens OX=9606 GN=QKI PE=1 SV=1" "0.000" "False" "10.528" "10" "3" "3" "3" "341" "37.6" "8.56" "9.09" "3" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf16544, Pf16551" "9444" "ENSG00000112531" "QKI" "hsa:9444; Q2I375; Q5MJQ1; Q969L9; Q96EJ3; Q96KA3; Q96PU6; Q96PU7; Q96PU8; Q9P0X6; Q9P0X7; Q9P0X8; Q9P0X9; Q9P0Y0; Q9P0Y1" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation" "Signaling by BRAF and RAF1 fusions" "3" "0" "1.104" "1.061" "1.088" "1.097" "1.107" "1.033" "1.025" "1.031" "1.056" "456.5" "504.1" "484.1" "496.6" "500.7" "505.1" "471.5" "467.8" "470.6" "482.0" "" "" "" "" "" "" "" "" "" "" "427.7" "417.1" "449.4" "383.9" "426.8" "482.6" "430.9" "415.4" "470.6" "464.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4254593612476960216" "False" "High" "IsMasterProtein" "Q9BTZ2" "Dehydrogenase/reductase SDR family member 4 OS=Homo sapiens OX=9606 GN=DHRS4 PE=1 SV=3" "0.000" "False" "10.526" "11" "4" "7" "4" "278" "29.5" "8.56" "21.36" "4" "other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf13561" "10901" "ENSG00000157326; ENSG00000284807" "DHRS4" "B2RB10; B7WNS9; D3YTB8; E2QRL8; hsa:10901; O95162; Q20CR0; Q2LC19; Q2LE81; Q58IU4; Q6E0Y1; Q6UWU3; Q71UQ6; Q8TD03; Q9BTZ2; Q9H3N5; Q9NV08" "" "Peroxisomal protein import; RA biosynthesis pathway" "2" "0" "0.994" "0.975" "0.985" "1.065" "1.090" "0.977" "0.998" "1.006" "1.015" "598.3" "594.6" "583.6" "589.6" "637.3" "652.4" "584.3" "597.2" "601.8" "607.2" "" "" "" "" "" "" "" "" "" "" "560.6" "492.0" "541.8" "455.8" "543.3" "623.3" "533.9" "530.3" "601.8" "584.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7803733859155002080" "False" "High" "IsMasterProtein" "A2RTX5" "Threonine--tRNA ligase 2, cytoplasmic OS=Homo sapiens OX=9606 GN=TARS3 PE=1 SV=1" "0.000" "False" "10.522" "4" "4" "4" "3" "802" "92.6" "6.05" "10.64" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00587, Pf02824, Pf03129, Pf07973" "123283" "ENSG00000185418" "TARS3" "A2RTX5; B2RMP7; hsa:123283; Q6B0A1; Q6IS76; Q96LW3; Q96MP4" "" "" "0" "0" "1.143" "1.125" "1.177" "1.109" "1.103" "1.099" "1.063" "1.046" "1.088" "387.3" "442.5" "435.7" "455.9" "429.4" "427.1" "425.5" "411.7" "405.1" "421.4" "" "" "" "" "" "" "" "" "" "" "362.9" "366.1" "404.5" "352.4" "366.0" "408.1" "388.8" "365.6" "405.1" "405.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5301300435928167882" "False" "High" "IsMasterProtein" "P47755" "F-actin-capping protein subunit alpha-2 OS=Homo sapiens OX=9606 GN=CAPZA2 PE=1 SV=3" "0.000" "False" "10.517" "13" "3" "6" "2" "286" "32.9" "5.85" "24.11" "3" "cell organization and biogenesis" "non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01267" "830" "ENSG00000198898" "CAPZA2" "B4DG50; hsa:830; P47755" "" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Sensory processing of sound by inner hair cells of the cochlea; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling" "7" "0" "1.089" "1.040" "1.155" "1.025" "1.040" "1.062" "0.907" "1.128" "1.074" "142.3" "155.0" "148.0" "164.3" "145.8" "148.0" "151.1" "129.1" "160.5" "152.8" "" "" "" "" "" "" "" "" "" "" "133.3" "128.3" "137.4" "127.0" "124.3" "141.4" "138.0" "114.6" "160.5" "147.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3620399161639766887" "False" "High" "IsMasterProtein" "Q99471" "Prefoldin subunit 5 OS=Homo sapiens OX=9606 GN=PFDN5 PE=1 SV=2" "0.000" "False" "10.504" "25" "3" "4" "3" "154" "17.3" "6.33" "11.57" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf02996" "5204" "ENSG00000123349; ENSG00000291834" "PFDN5" "A8K9A8; hsa:5204; Q54AA8; Q99471; Q9C083; Q9C084" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "1.048" "0.905" "0.987" "0.971" "0.972" "1.027" "0.975" "0.912" "0.911" "577.9" "605.8" "523.1" "570.3" "561.1" "561.8" "593.4" "563.5" "527.2" "526.4" "" "" "" "" "" "" "" "" "" "" "541.5" "501.3" "485.6" "440.8" "478.3" "536.7" "542.2" "500.3" "527.2" "506.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2326437507521645462" "False" "High" "IsMasterProtein" "Q9P2W1" "Homologous-pairing protein 2 homolog OS=Homo sapiens OX=9606 GN=PSMC3IP PE=1 SV=1" "0.000" "False" "10.499" "16" "4" "5" "4" "217" "24.9" "7.81" "15.78" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf07106, Pf18517" "29893" "ENSG00000131470" "PSMC3IP" "C5ILB7; hsa:29893; Q14458; Q8WXG2; Q96HA2; Q9P2W1" "Androgen receptor signaling pathway; Primary ovarian insufficiency" "Meiotic recombination" "3" "0" "1.143" "1.032" "1.093" "1.092" "1.076" "1.067" "1.063" "1.128" "1.094" "479.8" "548.3" "495.1" "524.2" "524.1" "516.1" "511.9" "510.2" "541.4" "524.8" "" "" "" "" "" "" "" "" "" "" "449.5" "453.7" "459.7" "405.2" "446.8" "493.1" "467.8" "453.0" "541.4" "505.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1566902771694482530" "False" "High" "IsMasterProtein" "P51153" "Ras-related protein Rab-13 OS=Homo sapiens OX=9606 GN=RAB13 PE=1 SV=1" "0.000" "False" "10.488" "10" "2" "5" "1" "203" "22.8" "9.19" "19.11" "2" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5872" "ENSG00000143545" "RAB13" "A8K6B5; D3DV67; hsa:5872; P51153; Q5U0A6; Q6GPG6; Q96GU4" "Leukocyte-intrinsic Hippo pathway functions" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Translocation of SLC2A4 (GLUT4) to the plasma membrane" "4" "0" "0.990" "0.958" "0.950" "0.971" "1.065" "1.028" "0.870" "0.982" "1.022" "166.5" "164.8" "159.5" "158.2" "161.7" "177.3" "171.2" "144.8" "163.5" "170.2" "" "" "" "" "" "" "" "" "" "" "156.0" "136.3" "148.1" "122.3" "137.8" "169.4" "156.5" "128.6" "163.5" "163.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4776370304497058949" "False" "High" "IsMasterProtein" "Q8IV04" "Carabin OS=Homo sapiens OX=9606 GN=TBC1D10C PE=1 SV=1" "0.000" "False" "10.487" "10" "5" "5" "5" "446" "49.7" "8.76" "14.40" "5" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "enzyme regulator activity" "Pf00566" "374403" "ENSG00000175463" "TBC1D10C" "G3V1D6; hsa:374403; Q8IV04" "" "Neutrophil degranulation; TBC/RABGAPs" "2" "0" "1.081" "1.024" "1.064" "1.066" "1.021" "1.038" "1.026" "1.043" "1.036" "762.1" "823.6" "780.1" "810.8" "812.8" "777.8" "791.3" "781.6" "795.0" "789.3" "" "" "" "" "" "" "" "" "" "" "714.1" "681.5" "724.2" "626.8" "692.8" "743.1" "723.0" "694.0" "795.0" "760.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "860011175530275491" "False" "High" "IsMasterProtein" "Q9H0Q0" "CYFIP-related Rac1 interactor A OS=Homo sapiens OX=9606 GN=CYRIA PE=1 SV=1" "0.000" "False" "10.487" "15" "4" "7" "3" "323" "37.3" "6.01" "17.10" "4" "cell organization and biogenesis" "other membranes" "other molecular function" "Pf07159" "81553" "ENSG00000197872" "CYRIA" "B3KNZ1; hsa:81553; Q53QW2; Q9H0Q0" "" "" "0" "0" "1.160" "1.146" "1.112" "1.010" "1.250" "1.120" "1.131" "1.131" "1.214" "71.8" "83.2" "82.3" "79.8" "72.5" "89.7" "80.4" "81.2" "81.2" "87.1" "" "" "" "" "" "" "" "" "" "" "67.3" "68.9" "76.4" "61.7" "61.8" "85.7" "73.5" "72.1" "81.2" "83.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3588161142439279914" "False" "High" "IsMasterProtein" "Q96RG2" "PAS domain-containing serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=PASK PE=1 SV=3" "0.000" "False" "10.479" "3" "5" "5" "5" "1323" "142.8" "4.86" "11.86" "5" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf13426" "23178" "ENSG00000115687" "PASK" "G5E9F1; hsa:23178; Q05BE4; Q68DY3; Q6GSJ5; Q86XH6; Q96RG2; Q99763; Q9UFR7" "2q37 copy number variation syndrome" "" "1" "0" "1.017" "0.979" "1.080" "1.026" "1.043" "1.010" "0.977" "0.980" "0.971" "621.3" "632.1" "608.1" "670.8" "637.7" "648.2" "627.4" "607.2" "608.7" "603.0" "" "" "" "" "" "" "" "" "" "" "582.1" "523.1" "564.5" "518.5" "543.6" "619.3" "573.3" "539.1" "608.7" "580.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5919366994915360532" "False" "High" "IsMasterProtein" "Q8NI60" "Atypical kinase COQ8A, mitochondrial OS=Homo sapiens OX=9606 GN=COQ8A PE=1 SV=1" "0.000" "False" "10.476" "5" "3" "6" "3" "647" "71.9" "6.99" "21.60" "3" "other metabolic processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf03109" "56997" "ENSG00000163050" "COQ8A" "hsa:56997; Q5T7A5; Q63HK0; Q8NCJ6; Q8NI60; Q9HBQ1; Q9NQ67" "" "" "0" "0" "1.000" "1.013" "1.002" "1.032" "1.037" "0.991" "0.949" "1.017" "1.010" "841.4" "841.1" "852.4" "843.1" "868.0" "872.5" "833.7" "798.7" "855.5" "849.9" "" "" "" "" "" "" "" "" "" "" "788.4" "696.0" "791.3" "651.7" "739.9" "833.6" "761.8" "709.2" "855.5" "818.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5412542927183305238" "False" "High" "IsMasterProtein" "P17535" "Transcription factor JunD OS=Homo sapiens OX=9606 GN=JUND PE=1 SV=3" "0.000" "False" "10.457" "11" "4" "4" "2" "347" "35.2" "7.37" "10.19" "4" "other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf03957" "3727" "ENSG00000130522" "JUND" "hsa:3727; P17535; Q53EK9" "Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; Angiotensin II receptor type 1 pathway; Hypertrophy model; 10q11.21q11.23 copy number variation syndrome; Osteoarthritic chondrocyte hypertrophy" "Estrogen-dependent gene expression; NGF-stimulated transcription" "14" "2" "1.005" "1.014" "1.067" "1.080" "1.025" "1.005" "1.095" "1.054" "0.972" "558.7" "561.6" "566.6" "595.9" "603.5" "572.4" "561.4" "611.9" "589.1" "542.9" "" "" "" "" "" "" "" "" "" "" "523.5" "464.7" "526.0" "460.7" "514.4" "546.9" "512.9" "543.3" "589.1" "522.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-630716066930521994" "False" "High" "IsMasterProtein" "P55957" "BH3-interacting domain death agonist OS=Homo sapiens OX=9606 GN=BID PE=1 SV=1" "0.000" "False" "10.449" "17" "3" "6" "3" "195" "22.0" "5.44" "15.77" "3" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf06393" "637" "ENSG00000015475" "BID" "hsa:637; P55957; Q549M7; Q71T04; Q7Z4M9; Q8IY86" "miRNA regulation of DNA damage response; TP53 network; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Apoptosis modulation by HSP70; Regulation of apoptosis by parathyroid hormone-related protein; miRNA regulation of p53 pathway in prostate cancer; Non-small cell lung cancer; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Unfolded protein response; Complement system in neuronal development and plasticity; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; DNA damage response" "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Activation, myristolyation of BID and translocation to mitochondria; Activation of BAD and translocation to mitochondria ; Activation and oligomerization of BAK protein; Activation, translocation and oligomerization of BAX" "30" "0" "1.095" "1.047" "1.065" "0.975" "1.012" "0.918" "0.986" "1.026" "0.993" "395.9" "433.4" "414.3" "421.5" "386.1" "400.7" "363.5" "390.2" "406.3" "393.0" "" "" "" "" "" "" "" "" "" "" "370.9" "358.7" "384.7" "325.8" "329.1" "382.8" "332.2" "346.4" "406.3" "378.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6931862210339099933" "False" "High" "IsMasterProtein" "Q9H1B7" "Probable E3 ubiquitin-protein ligase IRF2BPL OS=Homo sapiens OX=9606 GN=IRF2BPL PE=1 SV=1" "0.000" "False" "10.448" "5" "3" "3" "1" "796" "82.6" "8.24" "13.36" "3" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf11261" "64207" "ENSG00000119669" "IRF2BPL" "hsa:64207; Q8NDQ2; Q96JG2; Q9H1B7; Q9H3I7" "" "" "0" "0" "1.004" "0.985" "0.952" "1.051" "0.978" "1.047" "0.944" "1.059" "0.987" "120.3" "120.7" "118.4" "114.5" "126.4" "117.7" "125.9" "113.5" "127.3" "118.6" "" "" "" "" "" "" "" "" "" "" "112.7" "99.9" "109.9" "88.5" "107.7" "112.4" "115.0" "100.7" "127.3" "114.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8651766820472939276" "False" "High" "IsMasterProtein" "Q12792" "Twinfilin-1 OS=Homo sapiens OX=9606 GN=TWF1 PE=1 SV=3" "0.000" "False" "10.439" "13" "5" "7" "4" "350" "40.3" "6.96" "16.11" "5" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "5756" "ENSG00000151239" "TWF1" "A8K5A8; B3KXS6; B4DLX9; hsa:5756; Q12792; Q59G07; Q5U0B1; Q6FHJ1; Q6FHL6; Q6NUK9; Q86XL6; Q8TCD3" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHOBTB2 GTPase cycle" "3" "0" "0.939" "1.050" "0.948" "0.985" "0.970" "0.921" "0.981" "0.981" "0.967" "620.4" "582.6" "651.1" "588.3" "611.2" "601.9" "571.5" "608.7" "608.4" "599.8" "" "" "" "" "" "" "" "" "" "" "581.3" "482.1" "604.5" "454.8" "521.0" "575.0" "522.2" "540.4" "608.4" "577.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4372358057775812967" "False" "High" "IsMasterProtein" "Q9UMZ2" "Synergin gamma OS=Homo sapiens OX=9606 GN=SYNRG PE=1 SV=2" "0.000" "False" "10.438" "3" "4" "4" "4" "1314" "140.6" "5.03" "12.83" "4" "transport" "other membranes;ER/Golgi;other cell component" "" "" "11276" "ENSG00000274047; ENSG00000275066" "SYNRG" "A8MWU4; B7ZKZ2; B7ZKZ3; hsa:11276; Q17RI2; Q5BKU5; Q6ZT17; Q9UMZ2" "17q12 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4922430964326819838" "False" "High" "IsMasterProtein" "Q13686" "Nucleic acid dioxygenase ALKBH1 OS=Homo sapiens OX=9606 GN=ALKBH1 PE=1 SV=2" "0.000" "False" "10.432" "9" "3" "3" "3" "389" "43.8" "7.08" "9.84" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf13532" "8846" "ENSG00000100601" "ALKBH1" "Q13686; Q8TAU1; Q9ULA7" "" "" "0" "0" "0.970" "1.040" "1.007" "1.013" "1.092" "0.999" "1.029" "1.066" "1.679" "511.0" "495.5" "531.4" "514.5" "517.4" "557.9" "510.3" "525.8" "544.6" "857.7" "" "" "" "" "" "" "" "" "" "" "478.8" "410.0" "493.3" "397.7" "441.0" "533.0" "466.2" "466.9" "544.6" "825.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1047661720353379507" "False" "High" "IsMasterProtein" "Q03426" "Mevalonate kinase OS=Homo sapiens OX=9606 GN=MVK PE=1 SV=1" "0.000" "False" "10.429" "12" "4" "4" "4" "396" "42.4" "6.46" "14.06" "4" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00288, Pf08544" "4598" "ENSG00000110921" "MVK" "hsa:4598; Q03426" "Cholesterol biosynthesis pathway; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "8" "0" "1.001" "0.963" "1.024" "0.968" "0.981" "0.928" "0.917" "0.952" "0.927" "592.7" "593.3" "570.9" "607.0" "573.8" "581.7" "549.9" "543.3" "564.0" "549.7" "" "" "" "" "" "" "" "" "" "" "555.3" "491.0" "530.0" "469.2" "489.1" "555.7" "502.5" "482.4" "564.0" "529.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4788954663334132438" "False" "High" "IsMasterProtein" "Q9NWX6" "Probable tRNA(His) guanylyltransferase OS=Homo sapiens OX=9606 GN=THG1L PE=1 SV=2" "0.000" "False" "10.428" "12" "3" "3" "3" "298" "34.8" "8.00" "10.30" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response" "other membranes;cytosol;mitochondrion;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf04446, Pf14413" "54974" "ENSG00000113272" "THG1L" "D3DQJ5; hsa:54974; Q53G12; Q7L5R3; Q9H0S2; Q9NWX6" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.000" "1.155" "0.967" "1.036" "1.041" "0.971" "1.098" "1.119" "1.146" "240.3" "240.3" "277.6" "232.5" "249.0" "250.2" "233.5" "263.9" "269.0" "275.5" "" "" "" "" "" "" "" "" "" "" "225.2" "198.9" "257.7" "179.7" "212.3" "239.0" "213.3" "234.3" "269.0" "265.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7476977248749324952" "False" "High" "IsMasterProtein" "Q7Z4H8" "Protein O-glucosyltransferase 3 OS=Homo sapiens OX=9606 GN=POGLUT3 PE=1 SV=2" "0.000" "False" "10.427" "6" "4" "4" "4" "507" "58.5" "8.24" "12.53" "4" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf00630, Pf05686" "143888" "ENSG00000178202" "POGLUT3" "hsa:143888; Q6UWW2; Q6ZUM9; Q7Z4H8; Q8N7L8; Q8NE24" "" "" "0" "0" "0.986" "0.997" "1.091" "1.082" "1.067" "1.026" "1.040" "1.047" "1.093" "469.0" "462.6" "467.4" "511.7" "507.4" "500.5" "481.3" "487.8" "490.8" "512.8" "" "" "" "" "" "" "" "" "" "" "439.5" "382.8" "433.9" "395.6" "432.5" "478.2" "439.8" "433.2" "490.8" "493.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5163980209620091115" "False" "High" "IsMasterProtein" "O43598" "5-hydroxymethyl-dUMP N-hydrolase OS=Homo sapiens OX=9606 GN=DNPH1 PE=1 SV=1" "0.000" "False" "10.424" "29" "4" "5" "4" "174" "19.1" "5.05" "18.25" "4" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05014" "10591" "ENSG00000112667" "DNPH1" "B2LUJ9; hsa:10591; O43598" "" "Purine catabolism" "1" "0" "1.136" "0.966" "1.009" "0.944" "0.919" "0.905" "0.889" "0.965" "0.967" "450.7" "512.1" "435.2" "454.9" "425.4" "414.3" "408.0" "400.8" "434.7" "436.0" "" "" "" "" "" "" "" "" "" "" "422.3" "423.8" "404.0" "351.7" "362.6" "395.9" "372.8" "355.8" "434.7" "419.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8603881510889965526" "False" "High" "IsMasterProtein" "Q92889" "DNA repair endonuclease XPF OS=Homo sapiens OX=9606 GN=ERCC4 PE=1 SV=3" "0.000" "False" "10.419" "4" "4" "4" "4" "916" "104.4" "6.93" "14.31" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02732" "2072" "ENSG00000175595" "ERCC4" "A5PKV6; A8K111; hsa:2072; O00140; Q8TD83; Q92889" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Fanconi Anemia Pathway; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "8" "0" "0.901" "0.931" "0.955" "0.877" "0.896" "0.896" "0.953" "0.902" "1.011" "123.8" "111.5" "115.3" "118.2" "108.6" "110.9" "110.9" "118.0" "111.7" "125.1" "" "" "" "" "" "" "" "" "" "" "116.0" "92.3" "107.0" "91.4" "92.6" "106.0" "101.4" "104.7" "111.7" "120.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4225597047578388345" "False" "High" "IsMasterProtein" "Q9H334" "Forkhead box protein P1 OS=Homo sapiens OX=9606 GN=FOXP1 PE=1 SV=1" "0.000" "False" "10.410" "4" "3" "3" "3" "677" "75.3" "6.67" "10.42" "3" "stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf16159" "27086" "ENSG00000114861" "FOXP1" "A3QVP8; B3KV70; G5E9V8; hsa:27086; Q8NAN6; Q9BSG9; Q9H332; Q9H333; Q9H334; Q9P0R1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "546158601093739992" "False" "High" "IsMasterProtein" "Q8N9V3" "WD repeat, SAM and U-box domain-containing protein 1 OS=Homo sapiens OX=9606 GN=WDSUB1 PE=1 SV=4" "0.000" "False" "10.405" "8" "4" "4" "4" "476" "52.8" "6.37" "13.45" "4" "protein metabolism;other metabolic processes" "" "other molecular function" "Pf00400, Pf04564, Pf07647" "151525" "ENSG00000196151" "WDSUB1" "hsa:151525; Q53TI9; Q8N6N8; Q8N9V3" "" "" "0" "0" "0.958" "0.968" "0.989" "0.965" "1.000" "0.957" "0.987" "0.948" "0.997" "760.8" "729.1" "736.1" "752.4" "734.5" "760.7" "728.2" "751.1" "721.5" "758.3" "" "" "" "" "" "" "" "" "" "" "712.8" "603.3" "683.4" "581.6" "626.1" "726.8" "665.3" "666.9" "721.5" "730.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5424828533558395863" "False" "High" "IsMasterProtein" "O95352" "Ubiquitin-like modifier-activating enzyme ATG7 OS=Homo sapiens OX=9606 GN=ATG7 PE=1 SV=1" "0.000" "False" "10.404" "6" "4" "5" "4" "703" "77.9" "6.24" "10.80" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00899, Pf16420" "10533" "ENSG00000197548" "ATG7" "B4E170; E9PB95; hsa:10533; O95352; Q7L8L0; Q9BWP2; Q9UFH4" "Nanoparticle triggered autophagic cell death; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Clock-controlled autophagy in bone metabolism; Primary ovarian insufficiency; Autophagy in pancreatic ductal adenocarcinoma; ADHD and autism (ASD) linked metabolic pathways and SNP" "Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation; Signaling by BRAF and RAF1 fusions; Macroautophagy" "12" "0" "0.981" "0.910" "0.957" "1.015" "0.909" "0.911" "0.868" "0.920" "0.934" "210.2" "206.3" "191.2" "201.2" "213.4" "191.1" "191.5" "182.4" "193.3" "196.4" "" "" "" "" "" "" "" "" "" "" "197.0" "170.7" "177.5" "155.5" "181.9" "182.6" "175.0" "162.0" "193.3" "189.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3534429540462627294" "False" "High" "IsMasterProtein" "P09525" "Annexin A4 OS=Homo sapiens OX=9606 GN=ANXA4 PE=1 SV=4" "0.000" "False" "10.398" "13" "5" "8" "4" "319" "35.9" "6.13" "20.44" "5" "signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00191" "307" "ENSG00000196975" "ANXA4" "B4DDF9; hsa:307; P09525; Q6LES2; Q96F33; Q9BWK1" "Prostaglandin synthesis and regulation" "" "1" "0" "1.055" "1.009" "1.088" "1.142" "1.200" "1.171" "1.116" "1.079" "1.063" "335.4" "353.9" "338.5" "364.7" "383.0" "402.5" "392.7" "374.3" "361.7" "356.3" "" "" "" "" "" "" "" "" "" "" "314.2" "292.9" "314.2" "281.9" "326.4" "384.5" "358.8" "332.4" "361.7" "343.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6327174108011486304" "False" "High" "IsMasterProtein" "Q96CX6" "Leucine-rich repeat-containing protein 58 OS=Homo sapiens OX=9606 GN=LRRC58 PE=1 SV=2" "0.000" "False" "10.391" "8" "2" "3" "2" "371" "40.6" "6.84" "8.95" "2" "signal transduction" "" "" "Pf00560, Pf12799" "116064" "ENSG00000163428" "LRRC58" "hsa:116064; Q96CX6" "" "" "0" "0" "1.210" "1.043" "1.258" "1.120" "1.073" "1.123" "1.104" "1.172" "1.110" "104.9" "126.9" "109.4" "131.9" "117.5" "112.5" "117.7" "115.8" "122.9" "116.4" "" "" "" "" "" "" "" "" "" "" "98.2" "105.0" "101.6" "102.0" "100.1" "107.5" "107.6" "102.8" "122.9" "112.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9088626010110122517" "False" "High" "IsMasterProtein" "Q9UJX6" "Anaphase-promoting complex subunit 2 OS=Homo sapiens OX=9606 GN=ANAPC2 PE=1 SV=1" "0.000" "False" "10.390" "5" "5" "6" "5" "822" "93.8" "5.22" "10.96" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00888, Pf08672" "29882" "ENSG00000176248" "ANAPC2" "hsa:29882; Q5VSG1; Q96DG5; Q96GG4; Q9P2E1; Q9UJX6" "Cell cycle" "Separation of Sister Chromatids; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "1.068" "1.105" "0.991" "0.995" "1.010" "0.921" "0.904" "1.047" "1.006" "329.7" "352.0" "364.4" "326.7" "328.0" "333.0" "303.6" "298.1" "345.1" "331.7" "" "" "" "" "" "" "" "" "" "" "308.9" "291.3" "338.3" "252.6" "279.6" "318.2" "277.4" "264.7" "345.1" "319.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5422158606125759469" "False" "High" "IsMasterProtein" "Q86U42" "Polyadenylate-binding protein 2 OS=Homo sapiens OX=9606 GN=PABPN1 PE=1 SV=3" "0.000" "False" "10.379" "12" "4" "5" "4" "306" "32.7" "5.06" "11.64" "4" "RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "8106" "ENSG00000100836" "PABPN1" "D3DS49; hsa:8106; O43484; Q86U42" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "7" "0" "1.084" "1.016" "1.031" "1.046" "1.029" "1.092" "1.066" "1.212" "1.086" "661.9" "717.8" "672.7" "682.2" "692.5" "681.4" "722.7" "705.4" "802.2" "718.9" "" "" "" "" "" "" "" "" "" "" "620.2" "594.0" "624.6" "527.4" "590.2" "651.0" "660.4" "626.3" "802.2" "692.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4711793945183504944" "False" "High" "IsMasterProtein" "P23434" "Glycine cleavage system H protein, mitochondrial OS=Homo sapiens OX=9606 GN=GCSH PE=1 SV=2" "0.000" "False" "10.377" "17" "2" "6" "2" "173" "18.9" "4.88" "22.78" "2" "protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01597" "2653" "ENSG00000140905; ENSG00000291958" "GCSH" "hsa:2653; P23434; Q9H1E9" "" "Glycine degradation" "2" "0" "1.079" "1.067" "1.036" "1.110" "1.061" "0.989" "1.055" "1.151" "1.094" "626.4" "676.0" "668.2" "649.1" "695.1" "664.7" "619.8" "660.9" "721.0" "685.1" "" "" "" "" "" "" "" "" "" "" "587.0" "559.4" "620.3" "501.8" "592.5" "635.1" "566.3" "586.8" "721.0" "659.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6883226900925947322" "False" "High" "IsMasterProtein" "Q9BW83" "Intraflagellar transport protein 27 homolog OS=Homo sapiens OX=9606 GN=IFT27 PE=1 SV=1" "0.000" "False" "10.367" "21" "4" "7" "4" "186" "20.5" "5.41" "18.46" "4" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00071" "11020" "ENSG00000100360" "IFT27" "hsa:11020; O60897; Q9BW83" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; GDNF/RET signaling axis; Alstrom syndrome; Bardet-Biedl syndrome" "Intraflagellar transport" "8" "0" "1.008" "1.009" "1.136" "1.027" "1.066" "1.108" "0.978" "1.017" "1.019" "181.5" "183.0" "183.2" "206.1" "186.3" "193.4" "201.1" "177.5" "184.6" "184.8" "" "" "" "" "" "" "" "" "" "" "170.0" "151.4" "170.1" "159.3" "158.8" "184.8" "183.8" "157.6" "184.6" "178.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8467787264096672406" "False" "High" "IsMasterProtein" "O00506" "Serine/threonine-protein kinase 25 OS=Homo sapiens OX=9606 GN=STK25 PE=1 SV=1" "0.000" "False" "10.367" "10" "4" "4" "1" "426" "48.1" "6.74" "10.66" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "10494" "ENSG00000115694" "STK25" "A8K6Z3; A8K7D2; B7Z9K1; hsa:10494; O00506; Q15522; Q5BJF1" "2q37 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4634668291009869452" "False" "High" "IsMasterProtein" "Q9UNP9" "Peptidyl-prolyl cis-trans isomerase E OS=Homo sapiens OX=9606 GN=PPIE PE=1 SV=1" "0.000" "False" "10.366" "14" "4" "6" "4" "301" "33.4" "5.60" "14.94" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00160" "10450" "ENSG00000084072" "PPIE" "B2R971; hsa:10450; O43634; O43635; Q32Q72; Q3S611; Q5TGA0; Q5TGA2; Q5TGA3; Q9UIZ5; Q9UNP9" "" "mRNA Splicing - Major Pathway; Neutrophil degranulation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "6" "0" "1.047" "0.926" "0.999" "1.008" "0.980" "1.200" "1.014" "1.003" "1.067" "550.2" "576.0" "509.6" "549.9" "554.5" "539.4" "660.3" "557.8" "552.0" "586.9" "" "" "" "" "" "" "" "" "" "" "515.6" "476.6" "473.1" "425.1" "472.7" "515.3" "603.3" "495.3" "552.0" "565.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2272350597619465793" "False" "High" "IsMasterProtein" "O00743" "Serine/threonine-protein phosphatase 6 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP6C PE=1 SV=1" "0.000" "False" "10.343" "11" "3" "4" "3" "305" "35.1" "5.69" "10.50" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149" "5537" "ENSG00000119414" "PPP6C" "B2R5V6; B7Z2W9; B7Z5K9; hsa:5537; O00743; Q5U0A2; Q9UIC9" "" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "2" "0" "1.011" "1.014" "1.075" "0.955" "1.078" "0.964" "0.954" "0.971" "1.082" "305.7" "309.1" "310.0" "328.8" "292.0" "329.5" "294.6" "291.6" "296.7" "330.8" "" "" "" "" "" "" "" "" "" "" "286.5" "255.8" "287.8" "254.2" "248.9" "314.8" "269.2" "258.9" "296.7" "318.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1882529908578060163" "False" "High" "IsMasterProtein" "Q9HAS0" "Protein Njmu-R1 OS=Homo sapiens OX=9606 GN=C17orf75 PE=1 SV=2" "0.000" "False" "10.334" "9" "4" "5" "4" "396" "44.6" "5.03" "14.33" "4" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "" "Pf15053" "64149" "ENSG00000108666" "C17orf75" "hsa:64149; Q7Z2H4; Q9HAS0" "" "" "0" "0" "1.052" "1.047" "1.138" "1.065" "1.104" "1.089" "0.968" "1.077" "1.020" "381.5" "401.4" "399.2" "434.3" "406.1" "421.1" "415.2" "369.1" "411.0" "389.0" "" "" "" "" "" "" "" "" "" "" "357.4" "332.1" "370.7" "335.7" "346.1" "402.3" "379.4" "327.7" "411.0" "374.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4578961420069997890" "False" "High" "IsMasterProtein" "P31930" "Cytochrome b-c1 complex subunit 1, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC1 PE=1 SV=3" "0.000" "False" "10.326" "8" "5" "5" "4" "480" "52.6" "6.37" "12.36" "5" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00675, Pf05193" "7384" "ENSG00000010256" "UQCRC1" "B2R7R8; hsa:7384; P31930; Q96DD2" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "Respiratory electron transport" "4" "0" "0.952" "0.990" "0.907" "1.052" "1.074" "0.971" "0.957" "0.928" "0.951" "243.7" "232.1" "241.2" "221.0" "256.2" "261.7" "236.7" "233.2" "226.1" "231.9" "" "" "" "" "" "" "" "" "" "" "228.3" "192.0" "224.0" "170.8" "218.4" "250.1" "216.3" "207.1" "226.1" "223.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5795774045568999421" "False" "High" "IsMasterProtein" "Q9GZR7" "ATP-dependent RNA helicase DDX24 OS=Homo sapiens OX=9606 GN=DDX24 PE=1 SV=1" "0.000" "False" "10.317" "7" "4" "4" "4" "859" "96.3" "9.06" "11.91" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271" "57062" "ENSG00000089737; ENSG00000273761" "DDX24" "E7EMJ4; hsa:57062; Q4V9L5; Q9GZR7" "" "" "0" "0" "0.975" "1.007" "1.023" "1.143" "0.977" "1.243" "1.253" "1.071" "1.139" "97.9" "95.5" "98.5" "100.2" "111.8" "95.6" "121.7" "122.6" "104.8" "111.4" "" "" "" "" "" "" "" "" "" "" "91.7" "79.0" "91.5" "77.4" "95.3" "91.4" "111.2" "108.9" "104.8" "107.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8387736998001173674" "False" "High" "IsMasterProtein" "Q969T4" "Ubiquitin-conjugating enzyme E2 E3 OS=Homo sapiens OX=9606 GN=UBE2E3 PE=1 SV=1" "0.000" "False" "10.315" "19" "3" "5" "2" "207" "22.9" "7.18" "15.21" "3" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179" "10477" "ENSG00000170035" "UBE2E3" "B2RAD6; D3DPG3; hsa:10477; Q5U0R7; Q7Z4W4; Q969T4" "7q11.23 copy number variation syndrome" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "3" "0" "0.976" "0.976" "1.128" "0.977" "1.008" "1.041" "1.023" "1.054" "1.038" "212.6" "207.4" "207.4" "239.9" "207.7" "214.3" "221.3" "217.5" "224.1" "220.6" "" "" "" "" "" "" "" "" "" "" "199.2" "171.6" "192.6" "185.4" "177.1" "204.7" "202.2" "193.1" "224.1" "212.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "735333771594595677" "False" "High" "IsMasterProtein" "Q9BYN8" "Small ribosomal subunit protein mS26 OS=Homo sapiens OX=9606 GN=MRPS26 PE=1 SV=1" "0.000" "False" "10.313" "21" "4" "4" "4" "205" "24.2" "10.39" "9.02" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf14943" "64949" "ENSG00000125901" "MRPS26" "hsa:64949; Q96Q58; Q9BYN8" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.027" "1.002" "1.174" "1.026" "1.014" "1.011" "0.836" "0.890" "1.010" "481.7" "494.9" "482.6" "565.5" "494.2" "488.4" "487.2" "403.0" "429.0" "486.4" "" "" "" "" "" "" "" "" "" "" "451.4" "409.5" "448.1" "437.1" "421.3" "466.6" "445.2" "357.8" "429.0" "468.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-256514097134295092" "False" "High" "IsMasterProtein" "Q13546" "Receptor-interacting serine/threonine-protein kinase 1 OS=Homo sapiens OX=9606 GN=RIPK1 PE=1 SV=3" "0.000" "False" "10.308" "6" "3" "3" "3" "671" "75.9" "6.33" "10.16" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00531, Pf07714" "8737" "ENSG00000137275" "RIPK1" "A0AV89; B2RAG1; B4E3F9; hsa:8737; Q13180; Q13546; Q59H33" "Apoptosis modulation and signaling; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; TNF-alpha signaling pathway; Nanoparticle triggered regulated necrosis; Apoptosis; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; p38 MAPK signaling pathway; Cytosolic DNA-sensing pathway; Host-pathogen interaction of human coronaviruses - interferon induction; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Toll-like receptor signaling pathway" "IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Potential therapeutics for SARS; Ub-specific processing proteases; TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TLR3-mediated TICAM1-dependent programmed cell death; TNFR1-induced proapoptotic signaling; Defective RIPK1-mediated regulated necrosis; Ovarian tumor domain proteases; TRP channels; Microbial modulation of RIPK1-mediated regulated necrosis; SARS-CoV-1-mediated effects on programmed cell death" "35" "0" "1.058" "0.934" "1.465" "1.194" "1.020" "1.158" "1.342" "1.150" "1.014" "22.7" "24.0" "21.2" "33.2" "27.1" "23.1" "26.3" "30.4" "26.1" "23.0" "" "" "" "" "" "" "" "" "" "" "21.3" "19.9" "19.7" "25.7" "23.1" "22.1" "24.0" "27.0" "26.1" "22.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4457401366019025404" "False" "High" "IsMasterProtein" "Q7KZI7" "Serine/threonine-protein kinase MARK2 OS=Homo sapiens OX=9606 GN=MARK2 PE=1 SV=2" "0.000" "False" "10.305" "6" "5" "5" "5" "788" "87.9" "9.72" "9.60" "5" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00627, Pf02149" "2011" "ENSG00000072518" "MARK2" "hsa:2011; Q15449; Q15524; Q5XGA3; Q68A18; Q7KZI7; Q96HB3; Q96RG0" "Microtubule cytoskeleton regulation; Complement system in neuronal development and plasticity; Neurogenesis regulation in the olfactory epithelium" "" "3" "0" "1.068" "0.991" "1.094" "1.050" "0.998" "1.009" "0.995" "0.971" "1.007" "573.2" "612.1" "568.3" "627.0" "601.9" "571.9" "578.4" "570.4" "556.4" "577.2" "" "" "" "" "" "" "" "" "" "" "537.1" "506.5" "527.6" "484.7" "513.1" "546.4" "528.5" "506.4" "556.4" "555.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7158651141849584646" "False" "High" "IsMasterProtein" "Q9Y294" "Histone chaperone ASF1A OS=Homo sapiens OX=9606 GN=ASF1A PE=1 SV=1" "0.000" "False" "10.305" "17" "3" "5" "2" "204" "23.0" "4.41" "15.31" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04729" "25842" "ENSG00000111875" "ASF1A" "hsa:25842; Q6IA08; Q9P014; Q9Y294" "22q11.2 copy number variation syndrome" "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "2" "0" "1.101" "1.016" "1.138" "1.183" "1.047" "1.013" "1.092" "1.120" "1.144" "224.1" "246.8" "227.6" "255.1" "265.2" "234.6" "227.0" "244.7" "251.0" "256.4" "" "" "" "" "" "" "" "" "" "" "210.0" "204.3" "211.3" "197.2" "226.0" "224.1" "207.5" "217.3" "251.0" "246.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6130355325015870888" "False" "High" "IsMasterProtein" "Q9Y3E2" "BolA-like protein 1 OS=Homo sapiens OX=9606 GN=BOLA1 PE=1 SV=1" "0.000" "False" "10.282" "16" "2" "3" "2" "137" "14.3" "7.96" "10.44" "2" "cell organization and biogenesis;other biological processes" "cytosol;mitochondrion" "" "Pf01722" "51027" "ENSG00000178096" "BOLA1" "B2R7K2; D3DUZ4; hsa:51027; Q5QNY0; Q9Y3E2" "" "" "0" "0" "1.012" "1.235" "1.167" "1.319" "1.154" "1.271" "1.169" "0.960" "1.205" "51.9" "52.6" "64.1" "60.6" "68.5" "59.9" "66.0" "60.7" "49.9" "62.6" "" "" "" "" "" "" "" "" "" "" "48.7" "43.5" "59.5" "46.8" "58.4" "57.2" "60.3" "53.9" "49.9" "60.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8472695818303021401" "False" "High" "IsMasterProtein" "P22087" "rRNA 2'-O-methyltransferase fibrillarin OS=Homo sapiens OX=9606 GN=FBL PE=1 SV=2" "0.000" "False" "10.270" "10" "4" "5" "4" "321" "33.8" "10.18" "11.67" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01269" "2091" "ENSG00000105202; ENSG00000280548" "FBL" "B5BUE8; hsa:2091; O75259; P22087; Q6IAT5; Q9UPI6" "Rubinstein-Taybi syndrome 1" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1790933947294059226" "False" "High" "IsMasterProtein" "Q9H477" "Ribokinase OS=Homo sapiens OX=9606 GN=RBKS PE=1 SV=1" "0.000" "False" "10.269" "11" "3" "3" "3" "322" "34.1" "5.05" "9.99" "3" "other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00294" "64080" "ENSG00000171174" "RBKS" "A9UK04; B4DV96; hsa:64080; Q9H477" "" "Pentose phosphate pathway" "1" "0" "0.989" "1.013" "1.037" "1.033" "1.041" "0.925" "0.965" "1.042" "0.999" "358.8" "355.0" "363.4" "371.9" "370.8" "373.5" "331.9" "346.2" "373.8" "358.3" "" "" "" "" "" "" "" "" "" "" "336.2" "293.8" "337.4" "287.5" "316.1" "356.9" "303.3" "307.4" "373.8" "345.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1246779234316334068" "False" "High" "IsMasterProtein" "P49773" "Adenosine 5'-monophosphoramidase HINT1 OS=Homo sapiens OX=9606 GN=HINT1 PE=1 SV=2" "0.000" "False" "10.265" "24" "3" "5" "3" "126" "13.8" "6.95" "14.63" "3" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01230" "3094" "ENSG00000169567" "HINT1" "hsa:3094; P49773; Q9H5W8" "" "" "0" "0" "0.992" "0.933" "0.903" "0.890" "0.872" "0.901" "0.920" "0.847" "0.876" "1181.7" "1172.5" "1102.9" "1067.4" "1052.0" "1030.9" "1065.2" "1086.9" "1000.3" "1034.8" "" "" "" "" "" "" "" "" "" "" "1107.2" "970.2" "1023.9" "825.1" "896.7" "984.9" "973.3" "965.1" "1000.3" "996.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2630091394541072843" "False" "High" "IsMasterProtein" "Q9P2Y5" "UV radiation resistance-associated gene protein OS=Homo sapiens OX=9606 GN=UVRAG PE=1 SV=1" "0.000" "False" "10.255" "5" "4" "4" "4" "699" "78.1" "8.29" "13.51" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf10186" "7405" "ENSG00000198382" "UVRAG" "B3KTC1; hsa:7405; O00392; Q9P2Y5" "Nanoparticle triggered autophagic cell death; Autophagy" "Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; SARS-CoV-2 modulates autophagy" "6" "0" "0.978" "0.954" "0.984" "1.001" "1.040" "0.958" "0.938" "1.003" "1.010" "608.3" "594.7" "580.1" "598.7" "609.0" "632.9" "582.6" "570.6" "609.8" "614.2" "" "" "" "" "" "" "" "" "" "" "570.0" "492.1" "538.5" "462.8" "519.1" "604.7" "532.3" "506.7" "609.8" "591.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2106414634070186016" "False" "High" "IsMasterProtein" "Q8WVM8" "Sec1 family domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SCFD1 PE=1 SV=4" "0.000" "False" "10.247" "6" "4" "6" "4" "642" "72.3" "6.27" "15.32" "4" "stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00995" "23256" "ENSG00000092108" "SCFD1" "A8K2Z5; B7Z4U7; B7Z594; hsa:23256; O60754; O94990; Q7Z529; Q8WVM8; Q9BZI3; Q9UNL3; Q9Y6A8" "" "RHOA GTPase cycle; COPII-mediated vesicle transport" "2" "0" "0.983" "0.938" "1.113" "1.044" "1.017" "1.315" "1.309" "1.259" "1.147" "559.3" "550.0" "524.4" "622.5" "584.0" "568.7" "735.6" "731.9" "704.0" "641.3" "" "" "" "" "" "" "" "" "" "" "524.1" "455.1" "486.8" "481.2" "497.8" "543.3" "672.2" "649.8" "704.0" "617.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7694143023947037177" "False" "High" "IsMasterProtein" "Q96I15" "Selenocysteine lyase OS=Homo sapiens OX=9606 GN=SCLY PE=1 SV=4" "0.000" "False" "10.240" "8" "4" "5" "4" "445" "48.1" "7.12" "16.90" "4" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00266" "51540" "ENSG00000132330" "SCLY" "B9A068; hsa:51540; J3KN06; Q53SN1; Q53SN8; Q7L670; Q96I15; Q9NVT7; Q9NZR7" "Selenium metabolism and selenoproteins; 2q37 copy number variation syndrome" "Metabolism of ingested SeMet, Sec, MeSec into H2Se" "3" "0" "0.963" "1.005" "0.899" "0.994" "0.995" "0.926" "1.008" "1.072" "0.985" "451.1" "434.4" "453.6" "405.7" "448.5" "448.7" "417.7" "454.8" "483.8" "444.3" "" "" "" "" "" "" "" "" "" "" "422.7" "359.4" "421.1" "313.6" "382.3" "428.7" "381.7" "403.8" "483.8" "427.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6246281522193444266" "False" "High" "IsMasterProtein" "O60573" "Eukaryotic translation initiation factor 4E type 2 OS=Homo sapiens OX=9606 GN=EIF4E2 PE=1 SV=1" "0.000" "False" "10.234" "14" "3" "4" "3" "245" "28.3" "8.88" "15.28" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01652" "9470" "ENSG00000135930" "EIF4E2" "B8ZZJ9; hsa:9470; O60573; O75349" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance" "ISG15 antiviral mechanism" "4" "0" "0.963" "1.058" "1.155" "1.020" "0.997" "1.256" "1.145" "1.153" "1.128" "361.9" "348.6" "382.9" "417.8" "369.3" "360.6" "454.6" "414.4" "417.1" "408.2" "" "" "" "" "" "" "" "" "" "" "339.1" "288.5" "355.4" "323.0" "314.8" "344.6" "415.3" "368.0" "417.1" "393.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5027095919971470310" "False" "High" "IsMasterProtein" "Q5VVJ2" "Deubiquitinase MYSM1 OS=Homo sapiens OX=9606 GN=MYSM1 PE=1 SV=1" "0.000" "False" "10.234" "4" "4" "4" "4" "828" "95.0" "5.53" "8.74" "4" "cell organization and biogenesis;protein metabolism;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf01398, Pf04433" "114803" "ENSG00000162601" "MYSM1" "A8KA54; B3KX65; hsa:114803; Q5VVJ2; Q68DD3; Q6AI53; Q7Z3G8; Q96PX3" "" "Metalloprotease DUBs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-377515032386624778" "False" "High" "IsMasterProtein" "P78346" "Ribonuclease P protein subunit p30 OS=Homo sapiens OX=9606 GN=RPP30 PE=1 SV=1" "0.000" "False" "10.227" "11" "3" "4" "3" "268" "29.3" "8.91" "14.83" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01876" "10556" "ENSG00000148688" "RPP30" "B2R799; E9PB02; hsa:10556; P78346" "" "Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus" "2" "0" "1.036" "1.066" "1.153" "1.102" "1.013" "1.097" "1.083" "1.105" "1.078" "470.6" "487.5" "501.8" "542.6" "518.7" "476.5" "516.0" "509.5" "520.1" "507.2" "" "" "" "" "" "" "" "" "" "" "440.9" "403.4" "465.9" "419.4" "442.1" "455.3" "471.5" "452.4" "520.1" "488.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "57787487465406304" "False" "High" "IsMasterProtein" "Q08945" "FACT complex subunit SSRP1 OS=Homo sapiens OX=9606 GN=SSRP1 PE=1 SV=1" "0.000" "False" "10.214" "5" "3" "5" "3" "709" "81.0" "6.87" "17.08" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505, Pf03531, Pf08512, Pf17292, Pf21092, Pf21103" "6749" "ENSG00000149136" "SSRP1" "hsa:6749; Q08945; Q5BJG8" "" "Regulation of TP53 Activity through Phosphorylation; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "12" "0" "1.081" "1.078" "1.146" "1.194" "1.061" "1.474" "1.432" "1.390" "1.198" "222.4" "240.5" "239.8" "254.9" "265.5" "235.9" "327.8" "318.4" "309.1" "266.5" "" "" "" "" "" "" "" "" "" "" "208.4" "199.0" "222.6" "197.0" "226.3" "225.4" "299.5" "282.7" "309.1" "256.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9008676394331225875" "False" "High" "IsMasterProtein" "Q9ULV3" "Cip1-interacting zinc finger protein OS=Homo sapiens OX=9606 GN=CIZ1 PE=1 SV=2" "0.000" "False" "10.204" "5" "4" "4" "4" "898" "100.0" "6.11" "12.29" "4" "other biological processes" "plasma membrane;other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf12171" "25792" "ENSG00000148337" "CIZ1" "A8K9J8; B4E131; B7ZAS8; hsa:25792; Q5SYW3; Q5SYW5; Q8WU72; Q9H868; Q9NYM8; Q9UHK4; Q9ULV3; Q9Y3F9; Q9Y3G0" "" "" "0" "0" "0.985" "0.976" "0.947" "0.969" "1.009" "1.109" "0.911" "0.955" "1.013" "317.2" "312.6" "309.6" "300.3" "307.3" "320.0" "351.6" "289.1" "303.0" "321.3" "" "" "" "" "" "" "" "" "" "" "297.2" "258.6" "287.4" "232.2" "261.9" "305.8" "321.3" "256.7" "303.0" "309.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6058304427516802646" "False" "High" "IsMasterProtein" "Q7Z6J9" "tRNA-splicing endonuclease subunit Sen54 OS=Homo sapiens OX=9606 GN=TSEN54 PE=1 SV=3" "0.000" "False" "10.194" "7" "3" "3" "3" "526" "58.8" "7.91" "11.39" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf12928" "283989" "ENSG00000182173" "TSEN54" "hsa:283989; Q7Z6J9; Q86WV3; Q86XE4; Q8N9H2" "" "tRNA processing in the nucleus" "1" "0" "0.986" "0.994" "1.011" "1.049" "0.990" "0.987" "1.075" "1.058" "1.023" "330.9" "326.3" "328.8" "334.6" "347.1" "327.5" "326.7" "355.6" "350.1" "338.3" "" "" "" "" "" "" "" "" "" "" "310.0" "270.0" "305.2" "258.7" "295.9" "312.9" "298.5" "315.7" "350.1" "325.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8480986397388579687" "False" "High" "IsMasterProtein" "Q9UBB9" "Tuftelin-interacting protein 11 OS=Homo sapiens OX=9606 GN=TFIP11 PE=1 SV=1" "0.000" "False" "10.190" "4" "3" "3" "3" "837" "96.8" "5.67" "9.97" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "extracellular matrix;nucleus;other cell component" "nucleic acid binding activity" "Pf01585, Pf07842, Pf12457" "24144" "ENSG00000100109" "TFIP11" "hsa:24144; O95908; Q20WL0; Q5H8V8; Q9UBB9; Q9UGV7; Q9Y2Q8" "" "mRNA Splicing - Major Pathway" "1" "0" "1.071" "0.972" "1.004" "0.992" "0.977" "0.932" "0.915" "0.964" "0.936" "195.5" "209.3" "190.1" "196.2" "193.9" "191.0" "182.1" "178.8" "188.4" "183.0" "" "" "" "" "" "" "" "" "" "" "183.2" "173.2" "176.4" "151.7" "165.3" "182.4" "166.4" "158.8" "188.4" "176.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4618404774181820652" "False" "High" "IsMasterProtein" "P57076" "Cilia- and flagella-associated protein 298 OS=Homo sapiens OX=9606 GN=CFAP298 PE=1 SV=1" "0.000" "False" "10.187" "13" "4" "4" "3" "290" "33.2" "7.44" "12.75" "4" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf11069" "56683" "ENSG00000159079" "CFAP298" "hsa:56683; P57076; Q53FH0" "Ciliopathies" "" "1" "0" "0.944" "0.888" "0.995" "1.094" "1.062" "0.939" "0.948" "0.996" "1.025" "230.3" "217.4" "204.7" "229.1" "252.0" "244.5" "216.3" "218.4" "229.4" "236.1" "" "" "" "" "" "" "" "" "" "" "215.8" "179.9" "190.0" "177.1" "214.8" "233.6" "197.7" "194.0" "229.4" "227.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5985118232380264359" "False" "High" "IsMasterProtein" "Q15363" "Transmembrane emp24 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=TMED2 PE=1 SV=1" "0.000" "False" "10.184" "15" "3" "5" "3" "201" "22.7" "5.17" "9.61" "3" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "signal transduction activity or receptor binding" "Pf01105" "10959" "ENSG00000086598" "TMED2" "hsa:10959; Q15363" "5q35 copy number variation" "COPII-mediated vesicle transport; Cargo concentration in the ER; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; Pre-NOTCH Processing in Golgi" "6" "0" "1.055" "1.048" "1.134" "1.055" "1.142" "1.185" "1.088" "1.066" "1.103" "502.4" "530.0" "526.6" "569.8" "530.2" "573.9" "595.6" "546.5" "535.6" "554.1" "" "" "" "" "" "" "" "" "" "" "470.8" "438.5" "488.9" "440.5" "451.9" "548.3" "544.2" "485.2" "535.6" "533.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5208996323542288612" "False" "High" "IsMasterProtein" "Q8N5P1" "Zinc finger CCCH domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZC3H8 PE=1 SV=2" "0.000" "False" "10.174" "12" "4" "7" "4" "291" "33.6" "8.28" "10.08" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608, Pf18345" "84524" "ENSG00000144161" "ZC3H8" "hsa:84524; Q8N5P1; Q9BZ75" "2q13 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.054" "0.953" "0.995" "0.865" "0.940" "0.983" "0.872" "0.854" "0.976" "161.9" "170.7" "154.3" "161.1" "140.0" "152.2" "159.2" "141.2" "138.3" "158.0" "" "" "" "" "" "" "" "" "" "" "151.7" "141.3" "143.3" "124.5" "119.3" "145.4" "145.5" "125.4" "138.3" "152.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3766879511259281877" "False" "High" "IsMasterProtein" "Q96CM8" "Medium-chain acyl-CoA ligase ACSF2, mitochondrial OS=Homo sapiens OX=9606 GN=ACSF2 PE=1 SV=2" "0.000" "False" "10.168" "6" "4" "5" "4" "615" "68.1" "7.55" "17.52" "4" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00501, Pf13193" "80221" "ENSG00000167107" "ACSF2" "B4DFQ6; B4DHT5; B4DUF5; hsa:80221; Q96CM8; Q9H7G2" "Mitochondrial long chain fatty acid beta-oxidation; Mitochondrial fatty acid oxidation disorders" "Mitochondrial Fatty Acid Beta-Oxidation" "3" "0" "1.099" "1.131" "1.213" "1.070" "1.091" "1.093" "1.095" "1.023" "1.098" "174.0" "191.2" "196.8" "211.0" "186.1" "189.8" "190.1" "190.4" "177.9" "191.0" "" "" "" "" "" "" "" "" "" "" "163.0" "158.2" "182.7" "163.1" "158.6" "181.3" "173.7" "169.1" "177.9" "183.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5647730209445312513" "False" "High" "IsMasterProtein" "Q9BWT3" "Poly(A) polymerase gamma OS=Homo sapiens OX=9606 GN=PAPOLG PE=1 SV=2" "0.000" "False" "10.166" "6" "3" "3" "3" "736" "82.8" "9.14" "8.48" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf04926, Pf04928, Pf20750" "64895" "ENSG00000115421" "PAPOLG" "B2RBH4; hsa:64895; Q59G05; Q969N1; Q9BWT3; Q9H8L2; Q9HAD0" "" "" "0" "0" "1.005" "0.984" "1.180" "1.058" "1.075" "1.095" "0.963" "1.015" "1.015" "550.6" "553.2" "541.9" "650.0" "582.7" "592.2" "602.9" "530.4" "558.9" "559.0" "" "" "" "" "" "" "" "" "" "" "515.9" "457.7" "503.0" "502.5" "496.6" "565.8" "550.9" "471.0" "558.9" "538.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5951829502980748262" "False" "High" "IsMasterProtein" "Q92989" "Polyribonucleotide 5'-hydroxyl-kinase Clp1 OS=Homo sapiens OX=9606 GN=CLP1 PE=1 SV=1" "0.000" "False" "10.147" "7" "4" "4" "4" "425" "47.6" "6.62" "10.79" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf06807, Pf16573, Pf16575" "10978" "ENSG00000172409" "CLP1" "B2R7J6; B4DTI8; hsa:10978; Q92989" "mRNA processing" "tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "6" "0" "0.979" "0.935" "1.094" "1.002" "0.969" "1.021" "0.956" "0.934" "0.970" "678.3" "663.7" "634.5" "741.8" "679.9" "657.2" "692.8" "648.7" "633.3" "657.7" "" "" "" "" "" "" "" "" "" "" "635.6" "549.2" "589.1" "573.4" "579.5" "627.9" "633.0" "576.0" "633.3" "633.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4100918330742864628" "False" "High" "IsMasterProtein" "Q96GK7" "Oxaloacetate tautomerase FAHD2A, mitochondrial OS=Homo sapiens OX=9606 GN=FAHD2A PE=1 SV=1" "0.000" "False" "10.147" "11" "4" "5" "4" "314" "34.6" "8.24" "14.93" "4" "" "" "other molecular function" "Pf01557" "51011" "ENSG00000115042; ENSG00000292086" "FAHD2A" "hsa:51011; Q96GK7; Q9Y3B0" "" "" "0" "0" "1.086" "1.022" "1.250" "1.125" "1.062" "1.088" "1.050" "1.052" "1.127" "190.8" "207.2" "194.9" "238.5" "214.6" "202.7" "207.6" "200.3" "200.6" "215.1" "" "" "" "" "" "" "" "" "" "" "178.8" "171.5" "181.0" "184.4" "182.9" "193.6" "189.7" "177.9" "200.6" "207.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3715797868298302435" "False" "High" "IsMasterProtein" "Q5ST30" "Valine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=VARS2 PE=1 SV=2" "0.000" "False" "10.146" "3" "4" "4" "4" "1063" "118.4" "7.02" "8.74" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00133, Pf08264" "57176" "ENSG00000137411; ENSG00000223494" "VARS2" "A2ABL7; B4DET4; B4E3P5; F5GXJ0; F5H323; hsa:57176; Q2M2A0; Q59FI1; Q5SQ96; Q5SS98; Q5ST30; Q6DKJ5; Q6ZV24; Q96GN2; Q96H77; Q96Q02; Q9H6R2; Q9UFH7" "" "Mitochondrial tRNA aminoacylation" "1" "0" "1.046" "1.008" "1.088" "1.069" "1.041" "0.996" "0.970" "0.958" "1.005" "470.6" "492.1" "474.2" "511.9" "503.2" "489.9" "468.6" "456.2" "450.8" "473.1" "" "" "" "" "" "" "" "" "" "" "440.9" "407.2" "440.2" "395.8" "428.9" "468.1" "428.1" "405.1" "450.8" "455.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7881341601402710105" "False" "High" "IsMasterProtein" "Q8IYQ7" "Threonine synthase-like 1 OS=Homo sapiens OX=9606 GN=THNSL1 PE=1 SV=2" "0.000" "False" "10.126" "6" "5" "5" "5" "743" "83.0" "7.12" "11.96" "5" "" "other cell component" "" "Pf01202, Pf14821" "79896" "ENSG00000185875" "THNSL1" "B3KWL1; D3DRV3; hsa:79896; Q5VV21; Q8IYQ7" "" "" "0" "0" "1.052" "1.003" "1.002" "1.021" "1.007" "1.063" "1.005" "1.022" "0.987" "386.3" "406.5" "387.4" "386.9" "394.4" "389.2" "410.5" "388.4" "394.8" "381.3" "" "" "" "" "" "" "" "" "" "" "361.9" "336.4" "359.7" "299.1" "336.2" "371.8" "375.1" "344.8" "394.8" "367.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9137773696009286865" "False" "High" "IsMasterProtein" "P58546" "Myotrophin OS=Homo sapiens OX=9606 GN=MTPN PE=1 SV=2" "0.000" "False" "10.125" "22" "2" "6" "2" "118" "12.9" "5.52" "23.03" "2" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf12796" "136319" "ENSG00000105887" "MTPN" "hsa:136319; P58546" "" "" "0" "0" "0.997" "0.929" "0.912" "0.965" "0.945" "0.992" "0.990" "0.907" "0.942" "1492.0" "1487.3" "1386.7" "1360.3" "1440.3" "1409.2" "1479.6" "1477.4" "1353.5" "1404.9" "" "" "" "" "" "" "" "" "" "" "1398.0" "1230.7" "1287.4" "1051.6" "1227.7" "1346.4" "1352.0" "1311.8" "1353.5" "1352.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3647234260862617095" "False" "High" "IsMasterProtein" "Q8TEA8" "D-aminoacyl-tRNA deacylase 1 OS=Homo sapiens OX=9606 GN=DTD1 PE=1 SV=2" "0.000" "False" "10.122" "18" "4" "7" "4" "209" "23.4" "8.24" "17.57" "4" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02580" "92675" "ENSG00000125821" "DTD1" "A8K5X5; D3DW37; hsa:92675; Q496D1; Q5W184; Q8TEA8; Q8WXU8; Q9BW67; Q9H464; Q9H474" "" "" "0" "0" "0.966" "0.924" "0.971" "0.936" "0.994" "0.934" "1.041" "0.987" "0.951" "811.6" "783.7" "750.0" "787.8" "759.5" "806.3" "757.8" "845.2" "800.9" "771.7" "" "" "" "" "" "" "" "" "" "" "760.5" "648.5" "696.3" "609.0" "647.4" "770.4" "692.4" "750.5" "800.9" "743.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-329240465840991374" "False" "High" "IsMasterProtein" "Q6GMV3" "Putative peptidyl-tRNA hydrolase PTRHD1 OS=Homo sapiens OX=9606 GN=PTRHD1 PE=1 SV=1" "0.000" "False" "10.118" "21" "3" "4" "3" "140" "15.8" "9.10" "12.54" "3" "" "" "other molecular function" "Pf01981" "391356" "ENSG00000184924" "PTRHD1" "Q6GMV3" "" "" "0" "0" "1.001" "0.965" "0.881" "0.955" "0.978" "0.878" "0.985" "0.956" "0.961" "1115.1" "1116.7" "1076.2" "982.1" "1064.9" "1090.6" "979.3" "1098.5" "1066.2" "1071.9" "" "" "" "" "" "" "" "" "" "" "1044.9" "924.0" "999.1" "759.2" "907.7" "1041.9" "894.8" "975.4" "1066.2" "1032.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1639956808395934598" "False" "High" "IsMasterProtein" "Q9UKT4" "F-box only protein 5 OS=Homo sapiens OX=9606 GN=FBXO5 PE=1 SV=1" "0.000" "False" "10.112" "7" "4" "4" "4" "447" "50.1" "8.92" "12.93" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00646" "26271" "ENSG00000112029" "FBXO5" "B3KNX5; hsa:26271; Q5TF47; Q8WV29; Q9UGC8; Q9UKT4" "" "SCF-beta-TrCP mediated degradation of Emi1; G1/S-Specific Transcription; Phosphorylation of Emi1; Mitotic Metaphase/Anaphase Transition" "5" "0" "0.971" "0.963" "0.934" "0.921" "0.955" "0.869" "0.809" "0.814" "0.915" "953.3" "926.1" "918.3" "890.5" "877.5" "910.8" "828.3" "771.2" "775.8" "872.5" "" "" "" "" "" "" "" "" "" "" "893.2" "766.3" "852.5" "688.4" "748.0" "870.2" "756.8" "684.8" "775.8" "840.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8034699390765478794" "False" "High" "IsMasterProtein" "Q9UID3" "Vacuolar protein sorting-associated protein 51 homolog OS=Homo sapiens OX=9606 GN=VPS51 PE=1 SV=2" "0.000" "False" "10.110" "5" "4" "6" "4" "782" "86.0" "6.47" "16.23" "4" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08700" "738" "ENSG00000149823" "VPS51" "hsa:738; Q6PJV5; Q7L8A6; Q8WZ35; Q96DF4; Q96GR3; Q9UID3" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "1.037" "1.240" "1.131" "1.194" "1.091" "0.879" "0.990" "0.990" "1.224" "70.7" "73.3" "87.6" "79.9" "84.4" "77.1" "62.1" "70.0" "70.0" "86.5" "" "" "" "" "" "" "" "" "" "" "66.2" "60.6" "81.3" "61.8" "71.9" "73.7" "56.8" "62.1" "70.0" "83.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8367261200096812552" "False" "High" "IsMasterProtein" "O15091" "Mitochondrial ribonuclease P catalytic subunit OS=Homo sapiens OX=9606 GN=PRORP PE=1 SV=2" "0.000" "False" "10.105" "8" "5" "5" "5" "583" "67.3" "8.78" "12.50" "5" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf16953" "9692" "ENSG00000100890" "PRORP" "B4DXD9; B4E0S8; B4E211; C4AM93; D3DS99; D3DSA1; hsa:9692; O15091; Q86SZ4; Q86YB5; Q8N5L5" "" "tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion" "3" "0" "0.998" "0.984" "1.045" "1.092" "1.043" "1.124" "1.088" "1.013" "1.029" "390.2" "389.5" "384.0" "407.7" "425.9" "406.9" "438.7" "424.3" "395.3" "401.6" "" "" "" "" "" "" "" "" "" "" "365.6" "322.3" "356.5" "315.2" "363.0" "388.7" "400.9" "376.7" "395.3" "386.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5964921006077680004" "False" "High" "IsMasterProtein" "Q92522" "Histone H1.10 OS=Homo sapiens OX=9606 GN=H1-10 PE=1 SV=1" "0.000" "False" "10.091" "16" "3" "4" "3" "213" "22.5" "10.76" "16.85" "3" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "8971" "ENSG00000184897" "H1-10" "hsa:8971; Q92522" "" "" "0" "0" "1.289" "0.957" "0.976" "1.115" "0.955" "1.026" "0.821" "0.980" "0.960" "307.5" "396.5" "294.2" "300.1" "342.8" "293.7" "315.4" "252.4" "301.2" "295.2" "" "" "" "" "" "" "" "" "" "" "288.1" "328.1" "273.1" "232.0" "292.2" "280.6" "288.2" "224.1" "301.2" "284.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9207268972416967358" "False" "High" "IsMasterProtein" "O15066" "Kinesin-like protein KIF3B OS=Homo sapiens OX=9606 GN=KIF3B PE=1 SV=1" "0.000" "False" "10.082" "5" "4" "4" "4" "747" "85.1" "7.69" "11.96" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "9371" "ENSG00000101350" "KIF3B" "B2RMP4; B4DSR5; E1P5M5; hsa:9371; O15066" "" "Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Kinesins" "5" "0" "1.072" "1.065" "1.022" "1.058" "1.075" "0.984" "0.962" "1.071" "1.074" "484.1" "518.8" "515.6" "494.6" "512.1" "520.3" "476.4" "465.5" "518.4" "520.0" "" "" "" "" "" "" "" "" "" "" "453.6" "429.3" "478.7" "382.4" "436.5" "497.1" "435.3" "413.3" "518.4" "500.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1892003299666365822" "False" "High" "IsMasterProtein" "P60484" "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Homo sapiens OX=9606 GN=PTEN PE=1 SV=1" "0.000" "False" "10.069" "9" "4" "5" "4" "403" "47.1" "6.37" "15.00" "4" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00102, Pf10409" "5728" "ENSG00000171862; ENSG00000284792" "PTEN" "B2R904; F2YHV0; O00633; O02679; P60484; Q6ICT7" "Androgen receptor signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; T cell receptor and co-stimulatory signaling; Focal adhesion; Hepatocyte growth factor receptor signaling; Copper homeostasis; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of p53 pathway in prostate cancer; Clear cell renal cell carcinoma pathways; Endometrial cancer; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Breast cancer pathway; Extracellular vesicles in the crosstalk of cardiac cells; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; 16p11.2 proximal deletion syndrome; p53 transcriptional gene network; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; Urotensin-II-mediated signaling pathway; TROP2 regulatory signaling; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map; DNA damage response (only ATM dependent)" "TP53 Regulates Metabolic Genes; Regulation of PTEN stability and activity; Downstream TCR signaling; Ub-specific processing proteases; Transcriptional Regulation by MECP2; Synthesis of PIPs at the plasma membrane; Synthesis of IP3 and IP4 in the cytosol; Ovarian tumor domain proteases; Negative regulation of the PI3K/AKT network; Regulation of PTEN localization; PTEN Loss of Function in Cancer; Regulation of PTEN mRNA translation" "55" "0" "0.955" "0.957" "0.958" "0.955" "0.925" "0.927" "0.897" "0.928" "0.943" "731.1" "698.5" "699.3" "700.7" "697.9" "676.3" "678.0" "655.7" "678.8" "689.7" "" "" "" "" "" "" "" "" "" "" "685.0" "578.0" "649.3" "541.7" "594.9" "646.2" "619.5" "582.2" "678.8" "664.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2918128559095144433" "False" "High" "IsMasterProtein" "Q9NRA8" "Eukaryotic translation initiation factor 4E transporter OS=Homo sapiens OX=9606 GN=EIF4ENIF1 PE=1 SV=2" "0.000" "False" "10.066" "4" "3" "3" "3" "985" "108.1" "8.32" "7.43" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10477" "56478" "ENSG00000184708" "EIF4ENIF1" "B1AKL2; B1AKL3; B2RBF1; hsa:56478; Q8NCF2; Q9H708; Q9NRA8" "Primary ovarian insufficiency; 10q11.21q11.23 copy number variation syndrome" "" "2" "0" "1.021" "1.051" "1.081" "1.129" "1.119" "1.087" "1.117" "1.027" "1.096" "233.5" "238.4" "245.5" "252.3" "263.6" "261.2" "253.9" "260.7" "239.8" "256.0" "" "" "" "" "" "" "" "" "" "" "218.8" "197.3" "227.9" "195.1" "224.7" "249.6" "232.0" "231.5" "239.8" "246.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3055099900900343627" "False" "High" "IsMasterProtein" "Q9P0M9" "Large ribosomal subunit protein bL27m OS=Homo sapiens OX=9606 GN=MRPL27 PE=1 SV=1" "0.000" "False" "10.065" "20" "3" "3" "3" "148" "16.1" "10.42" "10.42" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01016" "51264" "ENSG00000108826" "MRPL27" "B2RE14; hsa:51264; Q9P0M9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.858" "0.954" "0.987" "0.926" "0.972" "1.034" "0.869" "0.974" "0.922" "68.6" "58.8" "65.5" "67.7" "63.5" "66.7" "70.9" "59.6" "66.8" "63.2" "" "" "" "" "" "" "" "" "" "" "64.3" "48.7" "60.8" "52.3" "54.1" "63.7" "64.8" "52.9" "66.8" "60.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7740912979344048922" "False" "High" "IsMasterProtein" "Q99871" "HAUS augmin-like complex subunit 7 OS=Homo sapiens OX=9606 GN=HAUS7 PE=1 SV=4" "0.000" "False" "10.065" "13" "3" "3" "3" "358" "39.8" "4.75" "11.97" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "" "55559" "ENSG00000213397" "HAUS7" "B4DUH6; D3DWT9; Q96HS8; Q99871; Q9NP54; Q9UFH9" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "1.075" "1.041" "1.096" "1.070" "1.314" "0.900" "1.050" "0.990" "1.090" "47.1" "50.6" "49.0" "51.6" "50.4" "61.9" "42.4" "49.4" "46.6" "51.3" "" "" "" "" "" "" "" "" "" "" "44.1" "41.8" "45.5" "39.9" "42.9" "59.1" "38.7" "43.9" "46.6" "49.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3980746601808787358" "False" "High" "IsMasterProtein" "Q9P1U1" "Actin-related protein 3B OS=Homo sapiens OX=9606 GN=ACTR3B PE=1 SV=1" "0.000" "False" "10.064" "9" "4" "8" "1" "418" "47.6" "5.88" "22.56" "4" "" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "57180" "ENSG00000133627" "ACTR3B" "A8MTG1; B4DFW4; hsa:57180; Q7Z526; Q96BT2; Q9P1U1" "" "" "0" "0" "0.970" "0.975" "0.926" "0.918" "0.956" "0.979" "0.936" "0.902" "0.885" "244.8" "237.4" "238.7" "226.6" "224.8" "234.1" "239.6" "229.1" "220.9" "216.7" "" "" "" "" "" "" "" "" "" "" "229.3" "196.4" "221.6" "175.1" "191.6" "223.7" "218.9" "203.4" "220.9" "208.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6147929922391527183" "False" "High" "IsMasterProtein" "P49116" "Nuclear receptor subfamily 2 group C member 2 OS=Homo sapiens OX=9606 GN=NR2C2 PE=1 SV=1" "0.000" "False" "10.064" "6" "4" "4" "4" "596" "65.4" "6.28" "10.72" "4" "developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105" "7182" "ENSG00000177463" "NR2C2" "A8K3H5; B6ZGT8; hsa:7182; P49116; P55092" "Androgen receptor signaling pathway; Nuclear receptors; Hypothesized pathways in pathogenesis of cardiovascular disease; Epithelial to mesenchymal transition in colorectal cancer" "Nuclear Receptor transcription pathway" "5" "0" "1.019" "0.956" "1.061" "1.004" "0.985" "1.008" "0.940" "0.878" "0.990" "837.7" "853.5" "800.7" "889.1" "841.1" "825.2" "844.5" "787.0" "735.6" "829.7" "" "" "" "" "" "" "" "" "" "" "784.9" "706.3" "743.3" "687.3" "716.9" "788.4" "771.6" "698.8" "735.6" "798.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "702541733568471880" "False" "High" "IsMasterProtein" "Q5T0B9" "Zinc finger protein 362 OS=Homo sapiens OX=9606 GN=ZNF362 PE=1 SV=1" "0.000" "False" "10.063" "9" "4" "4" "1" "420" "45.8" "9.64" "11.93" "4" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "149076" "ENSG00000160094" "ZNF362" "hsa:149076; Q5T0B9; Q8WYU4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4657914547001490376" "False" "High" "IsMasterProtein" "P53778" "Mitogen-activated protein kinase 12 OS=Homo sapiens OX=9606 GN=MAPK12 PE=1 SV=3" "0.000" "False" "10.062" "8" "3" "5" "2" "367" "41.9" "6.39" "16.04" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6300" "ENSG00000188130" "MAPK12" "hsa:6300; P53778; Q14260; Q6IC53; Q99588; Q99672" "Integrin-mediated cell adhesion; Parkinson's disease pathway; S1P receptor signal transduction; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Regulatory circuits of the STAT3 signaling pathway; Hepatitis B infection; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Toll-like receptor signaling pathway" "VEGFA-VEGFR2 Pathway; Myogenesis; NOD1/2 Signaling Pathway; p38MAPK events; DSCAM interactions; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Negative regulation of MAPK pathway" "30" "0" "1.113" "1.026" "1.193" "0.996" "0.976" "1.011" "0.948" "0.992" "1.062" "131.9" "146.8" "135.4" "157.4" "131.4" "128.7" "133.4" "125.1" "130.8" "140.1" "" "" "" "" "" "" "" "" "" "" "123.6" "121.5" "125.7" "121.7" "112.0" "123.0" "121.9" "111.1" "130.8" "134.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2272121550069660062" "False" "High" "IsMasterProtein" "P35268" "Large ribosomal subunit protein eL22 OS=Homo sapiens OX=9606 GN=RPL22 PE=1 SV=2" "0.000" "False" "10.051" "30" "3" "5" "3" "128" "14.8" "9.19" "15.64" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01776" "6146" "ENSG00000116251" "RPL22" "B2R495; hsa:6146; P35268; Q6IBD1" "Cytoplasmic ribosomal proteins" "Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.076" "1.053" "1.274" "1.319" "1.193" "1.209" "1.136" "1.160" "1.080" "342.9" "369.1" "361.2" "436.9" "452.5" "409.1" "414.8" "389.7" "397.9" "370.3" "" "" "" "" "" "" "" "" "" "" "321.3" "305.4" "335.3" "337.7" "385.7" "390.8" "379.0" "346.0" "397.9" "356.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1944436007343456073" "False" "High" "IsMasterProtein" "Q9H7B4" "Histone-lysine N-methyltransferase SMYD3 OS=Homo sapiens OX=9606 GN=SMYD3 PE=1 SV=4" "0.000" "False" "10.037" "11" "4" "6" "4" "428" "49.1" "7.25" "16.65" "4" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00856, Pf01753" "64754" "ENSG00000185420" "SMYD3" "A8K0P0; B1AN38; hsa:64754; Q86TL8; Q8N5Z6; Q96AI5; Q9H7B4" "Histone modifications" "PKMTs methylate histone lysines" "2" "0" "0.954" "1.019" "1.075" "1.055" "1.070" "1.058" "0.951" "1.018" "0.944" "181.6" "173.2" "185.1" "195.2" "191.5" "194.4" "192.1" "172.6" "185.0" "171.5" "" "" "" "" "" "" "" "" "" "" "170.2" "143.3" "171.9" "150.9" "163.3" "185.7" "175.5" "153.3" "185.0" "165.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1378614036355870767" "False" "High" "IsMasterProtein" "Q9UIV1" "CCR4-NOT transcription complex subunit 7 OS=Homo sapiens OX=9606 GN=CNOT7 PE=1 SV=3" "0.000" "False" "10.033" "13" "3" "3" "3" "285" "32.7" "4.84" "8.97" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04857" "29883" "ENSG00000198791" "CNOT7" "A8MZM5; B3KMP1; B3KN35; D3DSP6; G3V108; hsa:29883; Q7Z530; Q9UIV1" "" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "1.088" "1.153" "1.198" "1.166" "1.091" "1.115" "1.172" "1.157" "1.140" "168.5" "183.3" "194.3" "201.9" "196.6" "183.8" "187.8" "197.5" "195.0" "192.1" "" "" "" "" "" "" "" "" "" "" "157.9" "151.7" "180.4" "156.1" "167.6" "175.6" "171.6" "175.3" "195.0" "185.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3386437626543326564" "False" "High" "IsMasterProtein" "Q9BWE0" "DNA-binding protein REPIN1 OS=Homo sapiens OX=9606 GN=REPIN1 PE=1 SV=1" "0.000" "False" "10.025" "8" "3" "3" "3" "567" "63.5" "9.98" "11.02" "3" "DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "29803" "ENSG00000214022" "REPIN1" "C9J3L7; D3DWZ1; hsa:29803; Q7LE03; Q9BUZ6; Q9BWE0; Q9NZH2; Q9UMP5" "" "" "0" "0" "1.003" "1.026" "1.146" "0.972" "1.054" "0.989" "0.912" "0.983" "1.096" "217.4" "218.0" "223.2" "249.2" "211.4" "229.2" "215.1" "198.3" "213.8" "238.2" "" "" "" "" "" "" "" "" "" "" "203.7" "180.4" "207.2" "192.6" "180.2" "218.9" "196.6" "176.1" "213.8" "229.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2059779998353867711" "False" "High" "IsMasterProtein" "Q58A45" "PAN2-PAN3 deadenylation complex subunit PAN3 OS=Homo sapiens OX=9606 GN=PAN3 PE=1 SV=3" "0.000" "False" "10.025" "5" "4" "4" "4" "887" "95.6" "8.57" "9.46" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf18101" "255967" "ENSG00000152520" "PAN3" "A0N0X1; A1A4Y8; A1A4Y9; B1ALF1; B7Z3W7; hsa:255967; Q0D2P2; Q58A45; Q5HYG6; Q5T515; Q5T516; Q5TBA0; Q76E13; Q8NBA6" "" "Deadenylation of mRNA" "1" "0" "1.031" "0.981" "0.998" "1.057" "1.050" "1.015" "1.006" "1.010" "1.047" "366.3" "377.9" "359.4" "365.7" "387.3" "384.8" "371.7" "368.6" "370.1" "383.6" "" "" "" "" "" "" "" "" "" "" "343.2" "312.7" "333.7" "282.7" "330.1" "367.6" "339.7" "327.3" "370.1" "369.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1875589299266399931" "False" "High" "IsMasterProtein" "Q14139" "Ubiquitin conjugation factor E4 A OS=Homo sapiens OX=9606 GN=UBE4A PE=1 SV=2" "0.000" "False" "10.019" "5" "5" "5" "5" "1066" "122.5" "5.24" "10.71" "5" "protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04564, Pf10408" "9354" "ENSG00000110344" "UBE4A" "B0YJB6; Q14139; Q2M1H0; Q6P5T4; Q7Z639" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.913" "0.879" "1.067" "1.002" "1.036" "1.022" "1.153" "1.067" "1.025" "133.0" "121.5" "116.9" "142.0" "133.3" "137.8" "136.0" "153.4" "141.9" "136.3" "" "" "" "" "" "" "" "" "" "" "124.7" "100.5" "108.5" "109.7" "113.7" "131.6" "124.3" "136.2" "141.9" "131.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7338672527715775280" "False" "High" "IsMasterProtein" "Q8IWL3" "Iron-sulfur cluster co-chaperone protein HscB OS=Homo sapiens OX=9606 GN=HSCB PE=1 SV=3" "0.000" "False" "10.017" "15" "4" "4" "4" "235" "27.4" "7.69" "10.92" "4" "cell organization and biogenesis;developmental processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf07743, Pf18256" "150274" "ENSG00000100209" "HSCB" "hsa:150274; Q8IWL3; Q9BWS7" "Iron-sulfur cluster biogenesis" "Mitochondrial protein import; Mitochondrial iron-sulfur cluster biogenesis" "3" "0" "0.995" "1.042" "1.069" "0.997" "1.068" "1.013" "1.024" "1.021" "1.020" "334.7" "333.0" "348.6" "358.0" "333.9" "357.4" "339.1" "342.9" "341.8" "341.6" "" "" "" "" "" "" "" "" "" "" "313.7" "275.6" "323.7" "276.7" "284.6" "341.4" "309.9" "304.4" "341.8" "328.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8843415988459270294" "False" "High" "IsMasterProtein" "Q7Z2W9" "Large ribosomal subunit protein bL21m OS=Homo sapiens OX=9606 GN=MRPL21 PE=1 SV=2" "0.000" "False" "10.016" "18" "4" "5" "4" "205" "22.8" "9.89" "14.90" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00829" "219927" "ENSG00000197345" "MRPL21" "A6NKU0; C9JPR2; hsa:219927; Q7Z2W9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.100" "1.172" "1.149" "1.059" "1.000" "1.060" "1.008" "1.017" "1.081" "621.3" "683.7" "728.4" "713.9" "657.7" "621.1" "658.5" "626.4" "631.9" "671.9" "" "" "" "" "" "" "" "" "" "" "582.2" "565.8" "676.2" "551.9" "560.6" "593.4" "601.7" "556.1" "631.9" "647.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2572043715436263453" "False" "High" "IsMasterProtein" "Q9H3R5" "Centromere protein H OS=Homo sapiens OX=9606 GN=CENPH PE=1 SV=1" "0.000" "False" "10.012" "16" "4" "4" "4" "247" "28.5" "5.29" "8.84" "4" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;nucleus;other cell component" "other molecular function" "Pf05837" "64946" "ENSG00000153044" "CENPH" "A8K3Y1; hsa:64946; Q9H3R5" "" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere" "7" "0" "0.951" "0.939" "1.020" "1.008" "1.103" "0.906" "0.922" "0.876" "0.992" "793.4" "754.8" "745.3" "809.0" "800.0" "875.4" "718.7" "731.2" "694.7" "786.9" "" "" "" "" "" "" "" "" "" "" "743.4" "624.5" "691.9" "625.4" "681.9" "836.3" "656.7" "649.2" "694.7" "757.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4270729495226616365" "False" "High" "IsMasterProtein" "Q9Y535" "DNA-directed RNA polymerase III subunit RPC8 OS=Homo sapiens OX=9606 GN=POLR3H PE=1 SV=1" "0.000" "False" "10.011" "27" "3" "3" "3" "204" "22.9" "4.58" "8.95" "3" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03876, Pf08292" "171568" "ENSG00000100413" "POLR3H" "B0QYH9; hsa:171568; Q5M7Y8; Q96AE3; Q9BY95; Q9Y535" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; Primary ovarian insufficiency" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "11" "0" "0.952" "1.011" "1.076" "1.003" "1.015" "1.065" "1.059" "1.003" "1.011" "266.5" "253.7" "269.3" "286.8" "267.4" "270.4" "283.8" "282.2" "267.4" "269.3" "" "" "" "" "" "" "" "" "" "" "249.7" "209.9" "250.0" "221.7" "227.9" "258.4" "259.3" "250.5" "267.4" "259.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9120451514636770754" "False" "High" "IsMasterProtein" "Q12979" "Active breakpoint cluster region-related protein OS=Homo sapiens OX=9606 GN=ABR PE=1 SV=2" "0.000" "False" "9.984" "3" "3" "5" "1" "859" "97.5" "6.55" "13.26" "3" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00168, Pf00620, Pf00621" "29" "ENSG00000159842; ENSG00000276016; ENSG00000278741" "ABR" "B3KW89; B7Z6H7; D3DTH3; D3DTH4; F5H3S2; F5H8B3; hsa:29; Q12979; Q13693; Q13694" "" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC3 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOC GTPase cycle; RAC2 GTPase cycle; RHOB GTPase cycle" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4634393773107864734" "False" "High" "IsMasterProtein" "P19474" "E3 ubiquitin-protein ligase TRIM21 OS=Homo sapiens OX=9606 GN=TRIM21 PE=1 SV=1" "0.000" "False" "9.953" "6" "3" "6" "3" "475" "54.1" "6.38" "21.78" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097, Pf00622, Pf00643, Pf13765" "6737" "ENSG00000132109" "TRIM21" "hsa:6737; P19474; Q5XPV5; Q96RF8" "" "Antigen processing: Ubiquitination & Proteasome degradation; KEAP1-NFE2L2 pathway; Interferon gamma signaling; Regulation of innate immune responses to cytosolic DNA; STING mediated induction of host immune responses" "5" "0" "0.954" "0.992" "1.016" "1.017" "0.976" "0.991" "0.986" "0.939" "0.955" "450.8" "430.2" "447.2" "457.9" "458.5" "439.9" "446.7" "444.6" "423.4" "430.3" "" "" "" "" "" "" "" "" "" "" "422.4" "356.0" "415.2" "354.0" "390.8" "420.3" "408.2" "394.7" "423.4" "414.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5796509123597455273" "False" "High" "IsMasterProtein" "Q14558" "Phosphoribosyl pyrophosphate synthase-associated protein 1 OS=Homo sapiens OX=9606 GN=PRPSAP1 PE=1 SV=2" "0.000" "False" "9.952" "10" "3" "4" "1" "356" "39.4" "7.20" "14.30" "3" "other metabolic processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf13793, Pf14572" "5635" "ENSG00000161542" "PRPSAP1" "B2R6M4; hsa:5635; Q14558; Q96H06" "" "" "0" "0" "1.454" "0.941" "1.377" "1.205" "0.900" "1.163" "0.862" "0.963" "1.055" "22.5" "32.7" "21.1" "30.9" "27.1" "20.2" "26.1" "19.4" "21.6" "23.7" "" "" "" "" "" "" "" "" "" "" "21.1" "27.1" "19.6" "23.9" "23.1" "19.3" "23.9" "17.2" "21.6" "22.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2026118880241708351" "False" "High" "IsMasterProtein" "A5PLN9" "Trafficking protein particle complex subunit 13 OS=Homo sapiens OX=9606 GN=TRAPPC13 PE=1 SV=2" "0.000" "False" "9.949" "8" "4" "5" "4" "417" "46.5" "5.60" "15.18" "4" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf06159" "80006" "ENSG00000113597" "TRAPPC13" "A5PLN9; hsa:80006; Q17RZ9; Q49A23; Q4JHG0; Q6MZG4; Q8TCM2; Q9H8I3" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "0.976" "0.966" "0.951" "0.992" "0.995" "1.003" "0.910" "0.942" "0.993" "728.5" "710.8" "703.5" "692.5" "722.8" "725.2" "730.6" "663.2" "686.1" "723.1" "" "" "" "" "" "" "" "" "" "" "682.6" "588.2" "653.1" "535.3" "616.1" "692.8" "667.6" "588.9" "686.1" "696.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8566997630735090852" "False" "High" "IsMasterProtein" "Q8NHU6" "Tudor domain-containing protein 7 OS=Homo sapiens OX=9606 GN=TDRD7 PE=1 SV=2" "0.000" "False" "9.940" "4" "5" "5" "5" "1098" "123.5" "7.21" "10.64" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other cell component" "nucleic acid binding activity" "Pf00567, Pf12872" "23424" "ENSG00000196116" "TDRD7" "A6NCI6; B2RBX3; B4DG99; B4DXF7; E7EQD4; hsa:23424; Q5VV27; Q8NHU6; Q96JT1; Q9UFF0; Q9Y2M3" "" "" "0" "0" "1.005" "1.005" "1.010" "1.062" "1.023" "0.990" "1.005" "1.008" "1.037" "518.1" "520.4" "520.9" "523.3" "550.3" "530.1" "513.1" "520.8" "522.3" "537.4" "" "" "" "" "" "" "" "" "" "" "485.4" "430.6" "483.6" "404.5" "469.0" "506.4" "468.9" "462.5" "522.3" "517.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4696215040566855502" "False" "High" "IsMasterProtein" "Q9H446" "RWD domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RWDD1 PE=1 SV=1" "0.000" "False" "9.933" "13" "4" "4" "4" "243" "27.9" "4.20" "9.28" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other cell component" "" "Pf05773, Pf16543" "51389" "ENSG00000111832" "RWDD1" "A8K3W2; A8MT24; hsa:51389; Q9H446; Q9Y313; Q9Y6B3" "" "Protein hydroxylation" "1" "0" "1.183" "1.207" "1.133" "1.082" "1.013" "0.839" "1.064" "1.116" "1.074" "620.1" "733.8" "748.3" "702.5" "670.7" "628.3" "520.0" "660.1" "692.0" "666.1" "" "" "" "" "" "" "" "" "" "" "581.0" "607.2" "694.7" "543.0" "571.7" "600.3" "475.1" "586.1" "692.0" "641.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4626223979709161938" "False" "High" "IsMasterProtein" "Q9NXX6" "Non-structural maintenance of chromosomes element 4 homolog A OS=Homo sapiens OX=9606 GN=NSMCE4A PE=1 SV=2" "0.000" "False" "9.917" "10" "4" "4" "4" "385" "44.3" "5.38" "7.03" "4" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf08743, Pf15412" "54780" "ENSG00000107672" "NSMCE4A" "hsa:54780; Q5SQQ5; Q6P673; Q8WY66; Q9BS90; Q9NXX6" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "1.064" "0.953" "1.054" "0.995" "1.096" "1.085" "1.021" "0.997" "1.031" "247.8" "263.6" "236.3" "261.2" "246.6" "271.6" "268.9" "253.1" "247.1" "255.6" "" "" "" "" "" "" "" "" "" "" "232.2" "218.2" "219.3" "201.9" "210.2" "259.5" "245.7" "224.7" "247.1" "246.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2780012699029809096" "False" "High" "IsMasterProtein" "Q9H9J2" "Large ribosomal subunit protein mL44 OS=Homo sapiens OX=9606 GN=MRPL44 PE=1 SV=1" "0.000" "False" "9.912" "11" "3" "3" "3" "332" "37.5" "8.40" "11.28" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;mitochondrion;translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "" "65080" "ENSG00000135900" "MRPL44" "hsa:65080; Q53S16; Q6IA62; Q9H821; Q9H9J2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.953" "1.047" "1.161" "1.187" "0.970" "1.086" "1.018" "0.986" "1.057" "64.1" "61.1" "67.1" "74.4" "76.1" "62.2" "69.6" "65.3" "63.2" "67.8" "" "" "" "" "" "" "" "" "" "" "60.1" "50.6" "62.3" "57.5" "64.9" "59.4" "63.6" "57.9" "63.2" "65.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7227038913092173690" "False" "High" "IsMasterProtein" "P32456" "Guanylate-binding protein 2 OS=Homo sapiens OX=9606 GN=GBP2 PE=1 SV=3" "0.000" "False" "9.908" "6" "3" "3" "2" "591" "67.2" "5.71" "8.98" "3" "stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02263, Pf02841" "2634" "ENSG00000162645" "GBP2" "hsa:2634; P32456; Q6GPH0; Q6IAU2; Q86TB0" "" "Interferon gamma signaling; Interferon alpha/beta signaling" "2" "0" "0.984" "0.931" "1.040" "1.000" "0.938" "0.891" "0.987" "0.962" "0.916" "106.3" "104.6" "99.0" "110.6" "106.3" "99.8" "94.7" "105.0" "102.3" "97.4" "" "" "" "" "" "" "" "" "" "" "99.6" "86.6" "91.9" "85.5" "90.6" "95.3" "86.5" "93.2" "102.3" "93.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3857525489381916364" "False" "High" "IsMasterProtein" "A8MXV4" "Acyl-coenzyme A diphosphatase NUDT19 OS=Homo sapiens OX=9606 GN=NUDT19 PE=1 SV=1" "0.000" "False" "9.906" "9" "3" "5" "3" "375" "42.2" "7.64" "19.68" "3" "other metabolic processes" "cytosol;other cytoplasmic organelle" "other molecular function" "" "390916" "ENSG00000213965" "NUDT19" "A8MXV4; hsa:390916" "" "Peroxisomal lipid metabolism; Peroxisomal protein import" "2" "0" "0.954" "1.027" "1.005" "1.016" "0.989" "1.012" "1.013" "0.925" "1.008" "938.4" "895.3" "964.2" "943.3" "953.1" "927.7" "949.7" "950.6" "867.8" "946.2" "" "" "" "" "" "" "" "" "" "" "879.3" "740.8" "895.2" "729.2" "812.4" "886.4" "867.8" "844.0" "867.8" "911.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3983981062552353097" "False" "High" "IsMasterProtein" "Q92600" "CCR4-NOT transcription complex subunit 9 OS=Homo sapiens OX=9606 GN=CNOT9 PE=1 SV=1" "0.000" "False" "9.906" "10" "3" "4" "3" "299" "33.6" "8.03" "11.61" "3" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04078" "9125" "ENSG00000144580" "CNOT9" "B2RPI0; B5MDQ4; B7Z1E5; hsa:9125; Q92600; Q96IX4" "" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "4" "0" "1.008" "1.028" "1.062" "1.078" "1.046" "1.027" "1.083" "1.032" "1.061" "773.6" "779.7" "795.3" "821.2" "833.6" "809.6" "794.4" "837.5" "798.1" "820.5" "" "" "" "" "" "" "" "" "" "" "724.9" "645.2" "738.3" "634.9" "710.6" "773.5" "725.9" "743.6" "798.1" "790.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8869464350434744721" "False" "High" "IsMasterProtein" "O95372" "Acyl-protein thioesterase 2 OS=Homo sapiens OX=9606 GN=LYPLA2 PE=1 SV=1" "0.000" "False" "9.902" "18" "4" "5" "4" "231" "24.7" "7.23" "14.52" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02230" "11313" "ENSG00000011009" "LYPLA2" "hsa:11313; O95372; Q7Z4Z2" "" "L1CAM interactions" "1" "0" "1.004" "0.988" "1.008" "1.065" "1.023" "0.968" "0.992" "0.973" "1.021" "220.3" "221.3" "217.7" "222.1" "234.7" "225.3" "213.2" "218.5" "214.4" "224.9" "" "" "" "" "" "" "" "" "" "" "206.4" "183.1" "202.1" "171.7" "200.0" "215.2" "194.8" "194.0" "214.4" "216.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8009088926221679389" "False" "High" "IsMasterProtein" "P40616" "ADP-ribosylation factor-like protein 1 OS=Homo sapiens OX=9606 GN=ARL1 PE=1 SV=1" "0.000" "False" "9.896" "13" "2" "3" "2" "181" "20.4" "5.72" "7.02" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00025" "400" "ENSG00000120805" "ARL1" "B4DWW1; hsa:400; P40616; P80417; Q53XB1" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "1.151" "1.120" "1.070" "1.090" "1.030" "1.139" "1.008" "1.100" "1.090" "171.4" "197.3" "191.9" "183.3" "186.7" "176.5" "195.3" "172.7" "188.5" "186.7" "" "" "" "" "" "" "" "" "" "" "160.6" "163.2" "178.2" "141.7" "159.2" "168.7" "178.4" "153.4" "188.5" "179.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2792434032950857374" "False" "High" "IsMasterProtein" "Q96HR3" "Mediator of RNA polymerase II transcription subunit 30 OS=Homo sapiens OX=9606 GN=MED30 PE=1 SV=1" "0.000" "False" "9.893" "20" "4" "4" "4" "178" "20.3" "8.27" "10.85" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11315" "90390" "ENSG00000164758" "MED30" "C6GKU9; hsa:90390; Q96HR3" "" "Generic Transcription Pathway; Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; RSV-host interactions" "4" "0" "1.074" "1.034" "1.080" "1.092" "1.134" "1.086" "1.093" "1.100" "1.032" "481.1" "516.8" "497.4" "519.4" "525.2" "545.7" "522.3" "525.7" "529.2" "496.6" "" "" "" "" "" "" "" "" "" "" "450.8" "427.6" "461.8" "401.5" "447.7" "521.3" "477.2" "466.8" "529.2" "478.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2939925399894006679" "False" "High" "IsMasterProtein" "Q9NWU2" "Glucose-induced degradation protein 8 homolog OS=Homo sapiens OX=9606 GN=GID8 PE=1 SV=1" "0.000" "False" "9.889" "18" "4" "9" "4" "228" "26.7" "4.97" "24.36" "4" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08513, Pf10607" "54994" "ENSG00000101193" "GID8" "E1P5I3; hsa:54994; Q8N5M5; Q9NWU2" "Ciliary landscape" "" "1" "0" "0.975" "0.864" "0.976" "1.014" "1.037" "0.977" "0.999" "0.912" "0.913" "689.5" "672.3" "595.4" "672.8" "699.4" "714.7" "674.0" "688.5" "628.9" "629.5" "" "" "" "" "" "" "" "" "" "" "646.1" "556.3" "552.8" "520.1" "596.2" "682.8" "615.8" "611.4" "628.9" "606.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2957461368778197343" "False" "High" "IsMasterProtein" "Q96I51" "RCC1-like G exchanging factor-like protein OS=Homo sapiens OX=9606 GN=RCC1L PE=1 SV=3" "0.000" "False" "9.889" "11" "3" "4" "3" "464" "49.9" "8.29" "14.58" "3" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00415, Pf13540" "81554" "ENSG00000274523" "RCC1L" "D3DXK0; F5GX55; F5H6C7; hsa:81554; Q548B1; Q8IW88; Q8N572; Q96I51; Q9H0G7" "" "" "0" "0" "1.037" "0.961" "1.111" "1.119" "1.053" "1.093" "1.072" "1.001" "1.042" "210.9" "218.8" "202.6" "234.3" "236.0" "222.0" "230.4" "226.1" "211.2" "219.8" "" "" "" "" "" "" "" "" "" "" "197.6" "181.0" "188.1" "181.1" "201.2" "212.1" "210.6" "200.8" "211.2" "211.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4267228453861492918" "False" "High" "IsMasterProtein" "Q8IVM0" "Coiled-coil domain-containing protein 50 OS=Homo sapiens OX=9606 GN=CCDC50 PE=1 SV=1" "0.000" "False" "9.885" "11" "3" "4" "3" "306" "35.8" "6.65" "14.18" "3" "other biological processes" "cytosol;other cell component" "other molecular function" "Pf15295" "152137" "ENSG00000152492" "CCDC50" "hsa:152137; Q86VH7; Q8IVM0" "" "" "0" "0" "0.945" "0.955" "1.005" "0.989" "0.890" "0.853" "0.861" "0.911" "0.838" "202.8" "191.6" "193.6" "203.8" "200.5" "180.5" "173.0" "174.7" "184.7" "169.9" "" "" "" "" "" "" "" "" "" "" "190.0" "158.5" "179.8" "157.5" "170.9" "172.4" "158.0" "155.1" "184.7" "163.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5613658654748761200" "False" "High" "IsMasterProtein" "P51617" "Interleukin-1 receptor-associated kinase 1 OS=Homo sapiens OX=9606 GN=IRAK1 PE=1 SV=2" "0.000" "False" "9.883" "5" "3" "3" "3" "712" "76.5" "6.62" "8.36" "3" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00531" "3654" "ENSG00000184216" "IRAK1" "D3DWW3; D3DWW4; hsa:3654; P51617; Q7Z5V4; Q96C06; Q96RL2" "IL-1 signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; IL1 and megakaryocytes in obesity; Melatonin metabolism and effects; Interleukin-1 induced activation of NF-kB; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; MYD88 distinct input-output pathway; ApoE and miR-146 in inflammation and atherosclerosis; Fibrin complement receptor 3 signaling pathway; miRNA role in immune response in sepsis; LTF danger signal response pathway; Signal transduction through IL1R; Measles virus infection; Hepatitis B infection; IL-18 signaling pathway; Network map of SARS-CoV-2 signaling pathway; Toll-like receptor signaling pathway" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; PIP3 activates AKT signaling; Transcriptional Regulation by MECP2; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "37" "0" "0.933" "0.981" "0.943" "1.015" "1.019" "0.966" "0.861" "0.920" "0.973" "196.7" "183.5" "193.0" "185.4" "199.7" "200.4" "190.1" "169.5" "181.1" "191.4" "" "" "" "" "" "" "" "" "" "" "184.3" "151.8" "179.2" "143.4" "170.3" "191.4" "173.7" "150.5" "181.1" "184.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8650097818779685703" "False" "High" "IsMasterProtein" "P62857" "Small ribosomal subunit protein eS28 OS=Homo sapiens OX=9606 GN=RPS28 PE=1 SV=1" "0.000" "False" "9.879" "46" "3" "5" "3" "69" "7.8" "10.70" "13.68" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01200" "6234" "ENSG00000233927" "RPS28" "hsa:6234; P25112; P62857" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.167" "1.068" "1.199" "1.075" "1.030" "1.261" "1.293" "1.054" "1.008" "636.0" "742.2" "679.2" "762.3" "683.5" "654.8" "801.7" "822.4" "670.6" "641.3" "" "" "" "" "" "" "" "" "" "" "595.9" "614.2" "630.6" "589.3" "582.6" "625.6" "732.5" "730.2" "670.6" "617.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5416177737731563011" "False" "High" "IsMasterProtein" "Q14457" "Beclin-1 OS=Homo sapiens OX=9606 GN=BECN1 PE=1 SV=2" "0.000" "False" "9.872" "8" "4" "4" "4" "450" "51.9" "4.89" "13.28" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04111, Pf15285, Pf17675" "8678" "ENSG00000126581" "BECN1" "B2R6N7; hsa:8678; O75595; Q14457; Q9UNA8" "Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; Pleural mesothelioma; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; Autophagy in pancreatic ductal adenocarcinoma; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy; RSV-host interactions; Ub-specific processing proteases; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "18" "0" "0.999" "0.992" "1.009" "1.058" "1.038" "1.039" "0.990" "0.997" "1.009" "414.6" "414.1" "411.3" "418.5" "438.5" "430.5" "430.7" "410.4" "413.3" "418.3" "" "" "" "" "" "" "" "" "" "" "388.5" "342.7" "381.9" "323.5" "373.8" "411.3" "393.6" "364.4" "413.3" "402.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5703778072310238355" "False" "High" "IsMasterProtein" "Q9Y6I3" "Epsin-1 OS=Homo sapiens OX=9606 GN=EPN1 PE=1 SV=2" "0.000" "False" "9.871" "8" "4" "5" "4" "576" "60.3" "4.83" "16.71" "4" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf01417" "29924" "ENSG00000063245" "EPN1" "hsa:29924; Q86ST3; Q9HA18; Q9Y6I3" "VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation" "5" "0" "0.955" "0.905" "0.978" "0.961" "1.035" "1.097" "0.976" "0.935" "1.007" "502.6" "480.0" "454.7" "491.5" "482.9" "520.4" "551.2" "490.5" "470.0" "506.3" "" "" "" "" "" "" "" "" "" "" "470.9" "397.2" "422.1" "380.0" "411.6" "497.1" "503.7" "435.5" "470.0" "487.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-140378452823337742" "False" "High" "IsMasterProtein" "Q9HCN4" "GPN-loop GTPase 1 OS=Homo sapiens OX=9606 GN=GPN1 PE=1 SV=1" "0.000" "False" "9.867" "9" "3" "3" "3" "374" "41.7" "4.92" "9.34" "3" "" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf03029" "11321" "ENSG00000198522" "GPN1" "B4DQJ5; B4DQM4; B4DXU4; B5MBZ5; hsa:11321; O76004; Q9HCN4" "" "" "0" "0" "0.989" "1.085" "0.973" "0.997" "1.039" "0.934" "0.959" "0.956" "1.007" "397.1" "392.8" "431.1" "386.5" "395.9" "412.7" "371.0" "380.7" "379.5" "399.8" "" "" "" "" "" "" "" "" "" "" "372.1" "325.0" "400.2" "298.7" "337.5" "394.3" "339.0" "338.0" "379.5" "385.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1355108408195266018" "False" "High" "IsMasterProtein" "Q6NZ67" "Mitotic-spindle organizing protein 2B OS=Homo sapiens OX=9606 GN=MZT2B PE=1 SV=1" "0.000" "False" "9.864" "27" "3" "3" "3" "158" "16.2" "10.15" "13.59" "3" "" "cytosol;cytoskeleton;nucleus" "" "Pf12926" "80097" "ENSG00000152082; ENSG00000292119" "MZT2B" "hsa:80097; Q6NZ67; Q96CG4" "" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "2" "0" "1.101" "1.070" "1.157" "1.076" "1.011" "1.074" "1.011" "1.022" "1.076" "443.4" "488.3" "474.5" "512.8" "477.2" "448.2" "476.0" "448.2" "453.2" "477.3" "" "" "" "" "" "" "" "" "" "" "415.5" "404.1" "440.5" "396.5" "406.8" "428.2" "435.0" "397.9" "453.2" "459.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4871299150167349072" "False" "High" "IsMasterProtein" "Q8TF68" "Zinc finger protein 384 OS=Homo sapiens OX=9606 GN=ZNF384 PE=1 SV=2" "0.000" "False" "9.858" "8" "4" "4" "1" "577" "63.2" "8.95" "11.31" "4" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13912" "171017" "ENSG00000126746" "ZNF384" "hsa:171017; O15407; Q7Z722; Q8N938; Q8TF68" "" "" "0" "2" "1.014" "1.006" "0.997" "1.012" "1.070" "0.987" "1.077" "1.059" "1.017" "346.9" "351.6" "349.0" "345.9" "351.0" "371.2" "342.4" "373.6" "367.5" "352.7" "" "" "" "" "" "" "" "" "" "" "325.0" "290.9" "324.0" "267.4" "299.2" "354.6" "312.8" "331.7" "367.5" "339.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6814802731580382634" "False" "High" "IsMasterProtein" "Q6SJ96" "TATA box-binding protein-like 2 OS=Homo sapiens OX=9606 GN=TBPL2 PE=2 SV=2" "0.000" "False" "9.855" "7" "3" "5" "3" "343" "38.0" "5.74" "13.36" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00352" "387332" "ENSG00000182521" "TBPL2" "hsa:387332; Q17RU8; Q6SJ96" "" "Germ layer formation at gastrulation" "1" "0" "0.920" "1.019" "0.862" "0.983" "1.029" "0.942" "1.007" "0.997" "0.984" "366.8" "337.4" "373.6" "316.0" "360.6" "377.5" "345.5" "369.5" "365.9" "360.9" "" "" "" "" "" "" "" "" "" "" "343.7" "279.2" "346.9" "244.3" "307.4" "360.6" "315.7" "328.0" "365.9" "347.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8809739148280005605" "False" "High" "IsMasterProtein" "P46776" "Large ribosomal subunit protein uL15 OS=Homo sapiens OX=9606 GN=RPL27A PE=1 SV=2" "0.000" "False" "9.849" "28" "4" "8" "4" "148" "16.6" "11.00" "20.47" "4" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "other molecular function" "Pf00828" "6157" "ENSG00000166441" "RPL27A" "B2R4B3; hsa:6157; P46776" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Protein hydroxylation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.923" "0.940" "0.997" "0.933" "0.967" "1.091" "0.961" "1.066" "0.946" "298.5" "275.6" "280.6" "297.5" "278.5" "288.6" "325.7" "286.9" "318.2" "282.4" "" "" "" "" "" "" "" "" "" "" "279.7" "228.0" "260.5" "230.0" "237.4" "275.7" "297.6" "254.7" "318.2" "271.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-675276312923681114" "False" "High" "IsMasterProtein" "Q96GY0" "Zinc finger C2HC domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ZC2HC1A PE=1 SV=2" "0.000" "False" "9.846" "11" "4" "4" "4" "325" "35.1" "9.82" "11.12" "4" "" "" "other molecular function" "Pf13913" "51101" "ENSG00000104427" "ZC2HC1A" "hsa:51101; Q96GY0; Q9Y372" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-911938199932515837" "False" "High" "IsMasterProtein" "Q9NZQ3" "NCK-interacting protein with SH3 domain OS=Homo sapiens OX=9606 GN=NCKIPSD PE=1 SV=1" "0.000" "False" "9.846" "5" "4" "4" "4" "722" "78.9" "6.38" "10.53" "4" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00018, Pf09431" "51517" "ENSG00000213672" "NCKIPSD" "B4DFL5; hsa:51517; Q6GU34; Q6SPF3; Q8TC10; Q9NZQ3; Q9UGM8" "" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "3" "0" "0.963" "1.031" "1.100" "1.086" "1.034" "0.991" "1.039" "0.935" "0.969" "140.1" "134.9" "144.4" "154.1" "152.1" "144.9" "138.8" "145.5" "130.9" "135.7" "" "" "" "" "" "" "" "" "" "" "131.2" "111.6" "134.1" "119.1" "129.7" "138.4" "126.8" "129.2" "130.9" "130.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4178938987355296714" "False" "High" "IsMasterProtein" "P62312" "U6 snRNA-associated Sm-like protein LSm6 OS=Homo sapiens OX=9606 GN=LSM6 PE=1 SV=1" "0.000" "False" "9.843" "43" "4" "7" "4" "80" "9.1" "9.58" "20.25" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01423" "11157" "ENSG00000164167" "LSM6" "hsa:11157; P62312; Q4W5J5; Q9Y4Y8" "" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "2" "0" "0.906" "0.973" "0.890" "0.962" "0.933" "0.960" "0.983" "0.911" "0.921" "1688.3" "1530.2" "1643.5" "1503.3" "1624.7" "1575.1" "1620.3" "1659.2" "1538.2" "1554.1" "" "" "" "" "" "" "" "" "" "" "1581.9" "1266.2" "1525.7" "1162.2" "1384.9" "1504.9" "1480.5" "1473.2" "1538.2" "1496.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3533689105478908948" "False" "High" "IsMasterProtein" "Q15369" "Elongin-C OS=Homo sapiens OX=9606 GN=ELOC PE=1 SV=1" "0.000" "False" "9.840" "35" "3" "6" "3" "112" "12.5" "4.78" "25.57" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03931" "6921" "ENSG00000154582" "ELOC" "E5RGD9; hsa:6921; Q15369; Q567Q6" "Dual hijack model of Vif in HIV infection; VEGFA-VEGFR2 signaling; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2" "Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Regulation of expression of SLITs and ROBOs; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Inactivation of CSF3 (G-CSF) signaling; Evasion by RSV of host interferon responses" "22" "0" "1.051" "0.901" "0.926" "0.947" "1.017" "0.924" "1.002" "1.006" "0.957" "518.9" "545.5" "467.7" "480.6" "491.5" "527.5" "479.4" "519.9" "522.2" "496.5" "" "" "" "" "" "" "" "" "" "" "486.2" "451.4" "434.2" "371.5" "419.0" "504.0" "438.0" "461.6" "522.2" "478.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5798091253452066801" "False" "High" "IsMasterProtein" "Cont_Q86YZ3" "Hornerin OS=Homo sapiens OX=9606 GN=HRNR PE=1 SV=2" "0.000" "True" "9.838" "5" "3" "3" "3" "2850" "282.2" "10.04" "8.16" "3" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01023" "388697" "ENSG00000197915" "HRNR" "hsa:388697; Q5DT20; Q5U1F4; Q86YZ3" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5982176321518383" "False" "High" "IsMasterProtein" "Q92572" "AP-3 complex subunit sigma-1 OS=Homo sapiens OX=9606 GN=AP3S1 PE=1 SV=1" "0.000" "False" "9.831" "18" "3" "3" "3" "193" "21.7" "5.39" "10.84" "3" "cell organization and biogenesis;transport;signal transduction" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01217" "1176" "ENSG00000177879" "AP3S1" "hsa:1176; O00647; O00676; O00721; O00727; Q53XL4; Q6ICQ2; Q92572" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "1.037" "1.020" "1.090" "1.246" "1.055" "1.055" "1.006" "0.922" "1.045" "528.2" "547.8" "538.7" "575.5" "658.0" "557.0" "557.1" "531.3" "487.2" "552.1" "" "" "" "" "" "" "" "" "" "" "495.0" "453.3" "500.1" "444.9" "560.9" "532.2" "509.1" "471.7" "487.2" "531.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4134532342981628088" "False" "High" "IsMasterProtein" "Q9BSV6" "tRNA-splicing endonuclease subunit Sen34 OS=Homo sapiens OX=9606 GN=TSEN34 PE=1 SV=1" "0.000" "False" "9.825" "10" "4" "6" "4" "310" "33.6" "8.43" "17.05" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01974" "79042" "ENSG00000170892; ENSG00000273896; ENSG00000274078; ENSG00000274129; ENSG00000274672; ENSG00000274796; ENSG00000275165; ENSG00000278605; ENSG00000278622; ENSG00000278712" "TSEN34" "A6NNB1; B0V3J1; hsa:79042; Q9BSV6; Q9BVT1; Q9H6H5" "" "tRNA processing in the nucleus" "1" "0" "1.070" "1.030" "0.982" "1.006" "1.035" "1.026" "0.958" "0.979" "0.990" "927.9" "993.0" "955.7" "911.3" "933.2" "959.9" "952.3" "889.1" "908.3" "918.7" "" "" "" "" "" "" "" "" "" "" "869.5" "821.7" "887.3" "704.5" "795.4" "917.1" "870.2" "789.4" "908.3" "884.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7432769003305581720" "False" "High" "IsMasterProtein" "Q9BXW6" "Oxysterol-binding protein-related protein 1 OS=Homo sapiens OX=9606 GN=OSBPL1A PE=1 SV=2" "0.000" "False" "9.822" "4" "4" "5" "4" "950" "108.4" "6.38" "16.27" "4" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf01237, Pf12796" "114876" "ENSG00000141447" "OSBPL1A" "B7Z7D3; hsa:114876; Q9BXW6; Q9BZF5; Q9NW87" "" "MHC class II antigen presentation; Synthesis of bile acids and bile salts" "2" "0" "1.023" "1.019" "1.107" "1.065" "1.125" "1.054" "1.066" "1.162" "1.164" "466.8" "477.6" "475.5" "516.5" "496.9" "525.1" "491.9" "497.6" "542.2" "543.2" "" "" "" "" "" "" "" "" "" "" "437.4" "395.2" "441.4" "399.3" "423.5" "501.6" "449.5" "441.8" "542.2" "523.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7043086942307680796" "False" "High" "IsMasterProtein" "P63220" "Small ribosomal subunit protein eS21 OS=Homo sapiens OX=9606 GN=RPS21 PE=1 SV=1" "0.000" "False" "9.818" "40" "3" "3" "3" "83" "9.1" "8.50" "10.15" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01249" "6227" "ENSG00000171858" "RPS21" "hsa:6227; P35265; P63220" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.187" "1.007" "1.185" "1.167" "1.091" "1.306" "1.318" "1.468" "1.174" "424.5" "503.7" "427.6" "503.0" "495.2" "463.1" "554.6" "559.4" "623.0" "498.5" "" "" "" "" "" "" "" "" "" "" "397.8" "416.8" "396.9" "388.9" "422.1" "442.5" "506.7" "496.7" "623.0" "480.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3835661040312072050" "False" "High" "IsMasterProtein" "Q9BUA3" "Spindlin interactor and repressor of chromatin-binding protein OS=Homo sapiens OX=9606 GN=SPINDOC PE=1 SV=3" "0.000" "False" "9.807" "10" "4" "4" "4" "381" "41.0" "5.01" "13.30" "4" "stress response;other biological processes" "nucleus;other cell component" "" "Pf18658" "144097" "ENSG00000168005" "SPINDOC" "hsa:144097; Q68CV7; Q6PHS2; Q96IH0; Q9BUA3" "" "" "0" "0" "1.134" "0.988" "1.093" "1.085" "1.098" "1.191" "0.891" "1.015" "1.112" "168.1" "190.6" "166.1" "183.7" "182.4" "184.6" "200.1" "149.8" "170.6" "186.8" "" "" "" "" "" "" "" "" "" "" "157.5" "157.7" "154.2" "142.0" "155.5" "176.4" "182.9" "133.0" "170.6" "179.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-502282286759796404" "False" "High" "IsMasterProtein" "O00411" "DNA-directed RNA polymerase, mitochondrial OS=Homo sapiens OX=9606 GN=POLRMT PE=1 SV=2" "0.000" "False" "9.801" "3" "3" "3" "3" "1230" "138.5" "8.98" "10.59" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00940, Pf14700" "5442" "ENSG00000099821" "POLRMT" "hsa:5442; O00411; O60370" "Mitochondrial gene expression" "Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis" "3" "0" "1.073" "0.997" "0.933" "1.073" "0.970" "0.876" "1.072" "0.958" "0.970" "53.8" "57.7" "53.7" "50.2" "57.8" "52.2" "47.1" "57.7" "51.6" "52.2" "" "" "" "" "" "" "" "" "" "" "50.4" "47.8" "49.8" "38.8" "49.2" "49.9" "43.1" "51.2" "51.6" "50.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2915122001344888094" "False" "High" "IsMasterProtein" "Q13136" "Liprin-alpha-1 OS=Homo sapiens OX=9606 GN=PPFIA1 PE=1 SV=1" "0.000" "False" "9.796" "3" "4" "5" "4" "1202" "135.7" "6.29" "9.73" "4" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf00536, Pf07647" "8500" "ENSG00000131626; ENSG00000288198" "PPFIA1" "A6NLE3; hsa:8500; Q13135; Q13136; Q14567; Q8N4I2" "Cell lineage map for neuronal differentiation" "Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3875322263221301035" "False" "High" "IsMasterProtein" "P51553" "Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3G PE=1 SV=1" "0.000" "False" "9.789" "8" "4" "5" "4" "393" "42.8" "8.50" "13.50" "4" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00180" "3421" "ENSG00000067829" "IDH3G" "E9PDD5; hsa:3421; P51553; Q9BUU5" "TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein import" "3" "0" "0.952" "0.888" "0.943" "0.911" "0.975" "0.982" "0.801" "0.938" "0.920" "225.9" "215.0" "200.5" "213.0" "205.8" "220.3" "221.8" "181.1" "211.8" "207.8" "" "" "" "" "" "" "" "" "" "" "211.7" "177.9" "186.1" "164.6" "175.4" "210.4" "202.7" "160.8" "211.8" "200.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-181287195693513573" "False" "High" "IsMasterProtein" "Q96EA4" "Protein Spindly OS=Homo sapiens OX=9606 GN=SPDL1 PE=1 SV=2" "0.000" "False" "9.786" "6" "4" "4" "4" "605" "70.1" "5.47" "11.52" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "54908" "ENSG00000040275" "SPDL1" "B4E393; C9JS47; hsa:54908; Q8TEC8; Q96EA4; Q9HD44; Q9NX97" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.346" "1.069" "0.409" "0.164" "0.208" "0.186" "0.161" "0.178" "0.164" "765.8" "265.1" "818.4" "313.0" "125.3" "159.5" "142.6" "123.2" "136.4" "125.4" "" "" "" "" "" "" "" "" "" "" "717.5" "219.3" "759.8" "241.9" "106.8" "152.4" "130.3" "109.4" "136.4" "120.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4223527727478599420" "False" "High" "IsMasterProtein" "Q9UBF8" "Phosphatidylinositol 4-kinase beta OS=Homo sapiens OX=9606 GN=PI4KB PE=1 SV=1" "0.000" "False" "9.783" "4" "3" "3" "3" "816" "91.3" "6.25" "10.44" "3" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00454, Pf21245" "5298" "ENSG00000143393" "PI4KB" "B4DGI2; hsa:5298; O15096; P78405; Q5VWB9; Q5VWC0; Q5VWC1; Q9BWR6; Q9UBF8" "" "Synthesis of PIPs at the Golgi membrane" "1" "0" "1.107" "1.067" "1.148" "1.098" "1.059" "1.144" "1.086" "1.093" "1.048" "565.5" "625.9" "603.6" "649.5" "621.0" "598.7" "646.9" "614.0" "618.3" "592.6" "" "" "" "" "" "" "" "" "" "" "529.9" "517.9" "560.4" "502.1" "529.3" "572.0" "591.1" "545.2" "618.3" "570.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2974134927255505490" "False" "High" "IsMasterProtein" "Q6VY07" "Phosphofurin acidic cluster sorting protein 1 OS=Homo sapiens OX=9606 GN=PACS1 PE=1 SV=2" "0.000" "False" "9.780" "3" "2" "4" "2" "963" "104.8" "7.74" "17.20" "2" "other biological processes" "cytosol;ER/Golgi" "other molecular function" "Pf10254" "55690" "ENSG00000175115" "PACS1" "hsa:55690; Q6PJY6; Q6PKB6; Q6VY07; Q7Z590; Q7Z5W4; Q8N8K6; Q96MW0; Q9NW92; Q9ULP5" "" "Nef mediated downregulation of MHC class I complex cell surface expression" "1" "0" "1.125" "0.983" "0.959" "0.940" "1.008" "0.858" "0.862" "0.929" "0.915" "146.3" "164.6" "143.8" "140.2" "137.6" "147.5" "125.5" "126.1" "135.8" "133.9" "" "" "" "" "" "" "" "" "" "" "137.1" "136.2" "133.5" "108.4" "117.3" "140.9" "114.7" "112.0" "135.8" "128.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7486166187731566186" "False" "High" "IsMasterProtein" "Q9BV57" "Acireductone dioxygenase OS=Homo sapiens OX=9606 GN=ADI1 PE=1 SV=1" "0.000" "False" "9.772" "25" "3" "4" "3" "179" "21.5" "5.68" "15.74" "3" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03079" "55256" "ENSG00000182551" "ADI1" "D6W4Y3; hsa:55256; Q53HW3; Q53QD3; Q57YV7; Q68CK2; Q6ZSF7; Q7Z512; Q96P85; Q9BV57; Q9NV57" "Methionine de novo and salvage pathway" "Methionine salvage pathway" "2" "0" "1.145" "0.964" "0.983" "0.961" "0.962" "0.879" "0.970" "1.014" "0.958" "504.9" "578.2" "486.9" "496.3" "485.1" "485.9" "443.8" "489.8" "512.2" "483.9" "" "" "" "" "" "" "" "" "" "" "473.1" "478.5" "452.0" "383.7" "413.5" "464.3" "405.5" "434.9" "512.2" "465.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2337623474681162042" "False" "High" "IsMasterProtein" "P18074" "General transcription and DNA repair factor IIH helicase subunit XPD OS=Homo sapiens OX=9606 GN=ERCC2 PE=1 SV=1" "0.000" "False" "9.771" "4" "4" "4" "4" "760" "86.9" "7.15" "10.39" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06733, Pf06777, Pf13307" "2068" "ENSG00000104884" "ERCC2" "hsa:2068; P18074; Q2TB78; Q2YDY2; Q7KZU6; Q8N721" "Fluoropyrimidine activity; Eukaryotic transcription initiation; Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Cytosolic iron-sulfur cluster assembly; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "36" "0" "0.949" "1.070" "1.168" "1.117" "1.021" "1.176" "0.992" "1.040" "0.989" "175.8" "166.8" "188.1" "205.3" "196.4" "179.5" "206.8" "174.4" "182.9" "173.8" "" "" "" "" "" "" "" "" "" "" "164.7" "138.0" "174.6" "158.7" "167.4" "171.5" "188.9" "154.9" "182.9" "167.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3678214923131327318" "False" "High" "IsMasterProtein" "Q96RQ3" "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=MCCC1 PE=1 SV=3" "0.000" "False" "9.768" "5" "3" "3" "3" "725" "80.4" "7.78" "10.08" "3" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00289, Pf00364, Pf02785, Pf02786" "56922" "ENSG00000078070" "MCCC1" "hsa:56922; Q59ES4; Q96RQ3; Q9H959; Q9NS97" "Amino acid metabolism" "Branched-chain amino acid catabolism; Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency" "4" "0" "1.011" "1.067" "1.025" "1.031" "1.104" "1.115" "1.013" "1.050" "1.007" "176.3" "178.2" "188.1" "180.8" "181.8" "194.8" "196.7" "178.6" "185.2" "177.5" "" "" "" "" "" "" "" "" "" "" "165.2" "147.5" "174.7" "139.7" "155.0" "186.1" "179.7" "158.6" "185.2" "170.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5735228591980069382" "False" "High" "IsMasterProtein" "Q9HD42" "Charged multivesicular body protein 1a OS=Homo sapiens OX=9606 GN=CHMP1A PE=1 SV=1" "0.000" "False" "9.765" "16" "4" "5" "4" "196" "21.7" "8.06" "15.48" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "5119" "ENSG00000131165" "CHMP1A" "A2RU09; hsa:5119; Q14468; Q15779; Q96G31; Q9HD42" "" "HCMV Late Events" "1" "0" "1.114" "0.959" "1.015" "1.015" "1.007" "0.990" "0.903" "0.936" "0.964" "835.5" "930.4" "801.6" "848.1" "847.7" "840.9" "826.7" "754.5" "782.2" "805.7" "" "" "" "" "" "" "" "" "" "" "782.8" "769.9" "744.2" "655.7" "722.5" "803.4" "755.4" "669.9" "782.2" "775.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1731274812714259147" "False" "High" "IsMasterProtein" "Q9NYJ8" "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 OS=Homo sapiens OX=9606 GN=TAB2 PE=1 SV=1" "0.000" "False" "9.764" "4" "3" "3" "3" "693" "76.4" "8.54" "11.12" "3" "stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02845" "23118" "ENSG00000055208" "TAB2" "B2RCC4; E1P5A0; hsa:23118; O94838; Q6I9W8; Q76N06; Q9NYJ8; Q9UFP7" "IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; MAPK signaling pathway; TLR4 signaling and tolerance; Exercise-induced circadian regulation; miRNA role in immune response in sepsis; Measles virus infection; Hepatitis B infection; Toll-like receptor signaling pathway" "Downstream TCR signaling; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; FCERI mediated NF-kB activation; CLEC7A (Dectin-1) signaling; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Nuclear signaling by ERBB4; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; TAK1-dependent IKK and NF-kappa-B activation ; TNFR1-induced NF-kappa-B signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway" "27" "0" "1.016" "0.948" "0.940" "1.015" "1.037" "0.938" "0.942" "0.985" "1.025" "443.6" "450.6" "420.5" "416.8" "450.5" "460.0" "416.1" "418.1" "437.0" "454.7" "" "" "" "" "" "" "" "" "" "" "415.7" "372.9" "390.3" "322.2" "384.0" "439.5" "380.2" "371.2" "437.0" "437.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6321776130452368548" "False" "High" "IsMasterProtein" "Q9H7Z6" "Histone acetyltransferase KAT8 OS=Homo sapiens OX=9606 GN=KAT8 PE=1 SV=2" "0.000" "False" "9.762" "9" "4" "4" "4" "458" "52.4" "8.27" "11.13" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01853, Pf11717, Pf17772" "84148" "ENSG00000103510" "KAT8" "A8K4Z1; G5E9P2; hsa:84148; Q659G0; Q7LC17; Q8IY59; Q8WYB4; Q8WZ14; Q9H7Z6; Q9HAC5; Q9NR35" "" "HATs acetylate histones; Formation of WDR5-containing histone-modifying complexes" "2" "0" "0.927" "0.956" "0.964" "0.979" "0.982" "0.949" "0.977" "0.920" "0.953" "596.7" "553.4" "570.6" "575.4" "583.9" "585.9" "566.5" "582.8" "548.8" "568.4" "" "" "" "" "" "" "" "" "" "" "559.1" "457.9" "529.8" "444.8" "497.7" "559.8" "517.6" "517.5" "548.8" "547.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1339372435308816495" "False" "High" "IsMasterProtein" "Q8IWT0" "Protein archease OS=Homo sapiens OX=9606 GN=ZBTB8OS PE=1 SV=2" "0.000" "False" "9.762" "16" "3" "5" "3" "167" "19.5" "4.49" "14.67" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf01951" "339487" "ENSG00000176261" "ZBTB8OS" "hsa:339487; Q5TGK5; Q6PDA1; Q8IWS9; Q8IWT0; Q8NEV6; Q8NEV7" "" "tRNA processing in the nucleus" "1" "0" "0.998" "1.005" "0.901" "0.995" "1.019" "0.901" "0.961" "0.960" "1.044" "500.2" "499.4" "502.7" "450.7" "497.9" "509.6" "450.4" "480.6" "480.0" "521.9" "" "" "" "" "" "" "" "" "" "" "468.7" "413.2" "466.7" "348.4" "424.4" "486.9" "411.6" "426.7" "480.0" "502.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7544877575899964257" "False" "High" "IsMasterProtein" "Q96C57" "Protein CUSTOS OS=Homo sapiens OX=9606 GN=CUSTOS PE=1 SV=2" "0.000" "False" "9.762" "14" "3" "3" "3" "262" "28.2" "9.42" "12.71" "3" "cell-cell signaling;signal transduction;other biological processes" "nucleus" "" "" "64897" "ENSG00000157895" "CUSTOS" "Q53HF0; Q96C57; Q9H9Z7" "" "" "0" "0" "1.166" "1.053" "1.233" "1.091" "1.229" "1.309" "1.167" "1.256" "1.044" "41.5" "48.4" "43.7" "51.2" "45.3" "51.0" "54.3" "48.4" "52.1" "43.3" "" "" "" "" "" "" "" "" "" "" "38.9" "40.1" "40.6" "39.6" "38.6" "48.8" "49.6" "43.0" "52.1" "41.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1999315358904826558" "False" "High" "IsMasterProtein" "P01040" "Cystatin-A OS=Homo sapiens OX=9606 GN=CSTA PE=1 SV=1" "0.000" "False" "9.761" "39" "3" "4" "3" "98" "11.0" "5.50" "15.22" "3" "cell adhesion;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00031" "1475" "ENSG00000121552" "CSTA" "hsa:1475; P01040; Q6IB90" "8p23.1 copy number variation syndrome" "Formation of the cornified envelope" "2" "0" "0.912" "0.981" "0.924" "0.958" "0.970" "0.930" "0.988" "0.919" "1.063" "283.3" "258.4" "277.9" "261.6" "271.5" "274.7" "263.5" "279.9" "260.2" "301.2" "" "" "" "" "" "" "" "" "" "" "265.4" "213.9" "258.0" "202.2" "231.4" "262.4" "240.8" "248.5" "260.2" "290.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4018200245095699536" "False" "High" "IsMasterProtein" "P55327" "Tumor protein D52 OS=Homo sapiens OX=9606 GN=TPD52 PE=1 SV=2" "0.000" "False" "9.757" "15" "3" "3" "3" "224" "24.3" "4.83" "8.33" "3" "transport;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf04201" "7163" "ENSG00000076554" "TPD52" "B7Z414; C9J502; D0UFD1; D0UFD2; D0UFD3; D0UFD4; D0UFD5; E5RKB4; hsa:7163; P55327; Q13056; Q53EK8; Q6FGP3; Q6FGS3; Q86YZ2; Q9UCX8" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "1.206" "1.015" "0.976" "1.063" "1.114" "1.085" "1.173" "0.984" "0.998" "98.4" "118.7" "100.0" "96.1" "104.6" "109.7" "106.8" "115.5" "96.9" "98.2" "" "" "" "" "" "" "" "" "" "" "92.2" "98.2" "92.8" "74.3" "89.2" "104.8" "97.6" "102.5" "96.9" "94.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6149624510723031081" "False" "High" "IsMasterProtein" "P30043" "Flavin reductase (NADPH) OS=Homo sapiens OX=9606 GN=BLVRB PE=1 SV=3" "0.000" "False" "9.749" "19" "3" "6" "3" "206" "22.1" "7.65" "15.51" "3" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf13460" "645" "ENSG00000090013" "BLVRB" "A6NKD8; B2R5C6; hsa:645; P30043; P32078; P53005; Q32LZ2" "Nuclear receptors meta-pathway; NRF2 pathway; IL-10 anti-inflammatory signaling pathway" "Cytoprotection by HMOX1; Heme degradation" "5" "0" "1.069" "0.848" "1.052" "1.131" "0.905" "0.970" "0.799" "1.007" "1.019" "74.6" "79.7" "63.2" "78.5" "84.3" "67.5" "72.4" "59.6" "75.1" "76.0" "" "" "" "" "" "" "" "" "" "" "69.9" "66.0" "58.7" "60.7" "71.9" "64.5" "66.1" "52.9" "75.1" "73.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3538094465215650253" "False" "High" "IsMasterProtein" "Q8N4J0" "Carnosine N-methyltransferase OS=Homo sapiens OX=9606 GN=CARNMT1 PE=1 SV=1" "0.000" "False" "9.741" "8" "4" "5" "4" "409" "47.2" "6.32" "12.67" "4" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf07942" "138199" "ENSG00000156017" "CARNMT1" "hsa:138199; Q7Z383; Q8N4J0; Q8N7C5" "" "Histidine catabolism" "1" "0" "1.022" "1.008" "1.027" "0.988" "0.981" "0.985" "0.982" "1.172" "1.021" "699.0" "714.1" "704.9" "718.2" "690.6" "685.7" "688.6" "686.7" "819.5" "713.7" "" "" "" "" "" "" "" "" "" "" "655.0" "590.9" "654.4" "555.2" "588.6" "655.1" "629.2" "609.7" "819.5" "687.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5259121706082363690" "False" "High" "IsMasterProtein" "Q6NS38" "DNA oxidative demethylase ALKBH2 OS=Homo sapiens OX=9606 GN=ALKBH2 PE=1 SV=1" "0.000" "False" "9.740" "12" "3" "3" "3" "261" "29.3" "9.66" "6.50" "3" "DNA metabolism;other metabolic processes;stress response" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13532" "121642" "ENSG00000189046" "ALKBH2" "A4PET2; hsa:121642; Q5XLE3; Q6NS38" "Direct reversal repair" "ALKBH2 mediated reversal of alkylation damage" "2" "0" "0.891" "0.894" "0.953" "0.958" "1.023" "0.835" "0.889" "0.871" "0.954" "373.4" "332.6" "333.8" "355.7" "357.6" "381.9" "311.9" "332.1" "325.2" "356.0" "" "" "" "" "" "" "" "" "" "" "349.8" "275.2" "309.9" "275.0" "304.8" "364.9" "285.0" "294.9" "325.2" "342.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6429762109324514714" "False" "High" "IsMasterProtein" "O75607" "Nucleoplasmin-3 OS=Homo sapiens OX=9606 GN=NPM3 PE=1 SV=3" "0.000" "False" "9.730" "19" "3" "4" "3" "178" "19.3" "4.63" "13.89" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03066" "10360" "ENSG00000107833" "NPM3" "hsa:10360; O75607; Q9UNY6" "" "" "0" "0" "0.961" "1.010" "0.945" "1.044" "1.076" "0.999" "1.065" "1.033" "0.978" "204.9" "196.9" "206.9" "193.7" "213.9" "220.4" "204.7" "218.3" "211.7" "200.4" "" "" "" "" "" "" "" "" "" "" "192.0" "162.9" "192.1" "149.7" "182.3" "210.6" "187.0" "193.8" "211.7" "192.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1270194887050037302" "False" "High" "IsMasterProtein" "Q9UBW8" "COP9 signalosome complex subunit 7a OS=Homo sapiens OX=9606 GN=COPS7A PE=1 SV=1" "0.000" "False" "9.730" "14" "4" "4" "4" "275" "30.3" "8.22" "12.68" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf18392" "50813" "ENSG00000111652" "COPS7A" "A8K9A6; hsa:50813; Q9NVX3; Q9UBW8; Q9UJW4" "Ciliary landscape" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER" "5" "0" "0.883" "0.949" "0.987" "0.962" "0.988" "0.922" "0.939" "0.914" "0.936" "164.0" "144.8" "155.7" "161.8" "157.8" "162.0" "151.2" "154.1" "149.9" "153.5" "" "" "" "" "" "" "" "" "" "" "153.7" "119.9" "144.5" "125.1" "134.5" "154.8" "138.1" "136.8" "149.9" "147.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1360420814074918380" "False" "High" "IsMasterProtein" "Q5T653" "Large ribosomal subunit protein uL2m OS=Homo sapiens OX=9606 GN=MRPL2 PE=1 SV=2" "0.000" "False" "9.730" "10" "3" "3" "3" "305" "33.3" "11.30" "10.27" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00181, Pf03947" "51069" "ENSG00000112651" "MRPL2" "B2RC56; hsa:51069; Q5T653; Q8WUL1; Q96Q56; Q9Y311" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2803114814399122734" "False" "High" "IsMasterProtein" "Q8NFI3" "Cytosolic endo-beta-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=ENGASE PE=1 SV=1" "0.000" "False" "9.721" "6" "4" "4" "4" "743" "83.9" "6.79" "8.83" "4" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf03644" "64772" "ENSG00000167280" "ENGASE" "hsa:64772; Q659F0; Q8NFI3; Q8TB86; Q9H6U4" "" "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "1" "0" "1.059" "1.020" "1.201" "1.146" "1.033" "1.159" "1.064" "1.032" "1.029" "229.2" "242.8" "233.8" "275.3" "262.6" "236.8" "265.6" "243.9" "236.7" "236.0" "" "" "" "" "" "" "" "" "" "" "214.8" "200.9" "217.0" "212.9" "223.9" "226.3" "242.7" "216.6" "236.7" "227.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3949732143901396407" "False" "High" "IsMasterProtein" "O43427" "Acidic fibroblast growth factor intracellular-binding protein OS=Homo sapiens OX=9606 GN=FIBP PE=1 SV=3" "0.000" "False" "9.682" "8" "4" "4" "4" "364" "41.9" "6.48" "12.70" "4" "signal transduction" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf05427" "9158" "ENSG00000172500" "FIBP" "A8K0J7; hsa:9158; O43427; Q27Q85; Q6IBQ3; Q9HD65" "Modulators of TCR signaling and T cell activation" "" "1" "0" "0.946" "0.984" "0.983" "0.976" "0.996" "1.006" "0.947" "0.950" "0.989" "522.3" "494.1" "514.1" "513.2" "509.6" "520.3" "525.6" "494.4" "496.2" "516.6" "" "" "" "" "" "" "" "" "" "" "489.4" "408.9" "477.2" "396.7" "434.4" "497.1" "480.3" "439.0" "496.2" "497.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4835472215069796756" "False" "High" "IsMasterProtein" "Q9Y692" "Glucocorticoid modulatory element-binding protein 1 OS=Homo sapiens OX=9606 GN=GMEB1 PE=1 SV=2" "0.000" "False" "9.674" "5" "3" "4" "3" "573" "62.6" "4.83" "14.14" "3" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01342" "10691" "ENSG00000162419" "GMEB1" "B1AT48; hsa:10691; Q9NWH1; Q9UKD0; Q9Y692" "2q37 copy number variation syndrome" "" "1" "0" "1.102" "1.121" "1.232" "1.209" "0.975" "1.161" "1.067" "1.016" "0.981" "215.7" "237.6" "241.8" "265.8" "260.9" "210.3" "250.4" "230.1" "219.2" "211.7" "" "" "" "" "" "" "" "" "" "" "202.1" "196.6" "224.5" "205.5" "222.4" "200.9" "228.8" "204.3" "219.2" "203.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8933841314574218963" "False" "High" "IsMasterProtein" "Q99633" "Pre-mRNA-splicing factor 18 OS=Homo sapiens OX=9606 GN=PRPF18 PE=1 SV=1" "0.000" "False" "9.672" "12" "4" "5" "4" "342" "39.8" "8.15" "12.08" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02840, Pf08799" "8559" "ENSG00000165630" "PRPF18" "hsa:8559; Q5T9P9; Q99633; Q9BUI9" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.931" "1.009" "0.928" "0.997" "1.074" "1.037" "1.060" "1.074" "1.063" "412.9" "384.2" "416.5" "383.2" "411.7" "443.5" "428.3" "437.6" "443.4" "439.0" "" "" "" "" "" "" "" "" "" "" "386.9" "317.9" "386.6" "296.2" "350.9" "423.7" "391.4" "388.6" "443.4" "422.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4407063102303430808" "False" "High" "IsMasterProtein" "P23378" "Glycine dehydrogenase (decarboxylating), mitochondrial OS=Homo sapiens OX=9606 GN=GLDC PE=1 SV=2" "0.000" "False" "9.665" "3" "3" "5" "3" "1020" "112.7" "7.11" "14.23" "3" "other metabolic processes;other biological processes" "plasma membrane;other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01212, Pf02347, Pf21478" "2731" "ENSG00000178445" "GLDC" "hsa:2731; P23378; Q2M2F8" "Metabolic Epileptic Disorders" "Glycine degradation" "2" "0" "1.020" "1.014" "1.077" "1.047" "1.011" "0.954" "0.888" "0.975" "0.986" "322.3" "328.7" "326.9" "347.1" "337.5" "325.8" "307.4" "286.1" "314.4" "317.6" "" "" "" "" "" "" "" "" "" "" "302.0" "272.0" "303.5" "268.3" "287.7" "311.3" "280.9" "254.0" "314.4" "305.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1224070834007844842" "False" "High" "IsMasterProtein" "Q9BW91" "ADP-ribose pyrophosphatase, mitochondrial OS=Homo sapiens OX=9606 GN=NUDT9 PE=1 SV=1" "0.000" "False" "9.662" "13" "4" "4" "4" "350" "39.1" "8.22" "10.81" "4" "other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00293" "53343" "ENSG00000170502" "NUDT9" "hsa:53343; Q8NBN1; Q8NCB9; Q8NG25; Q9BW91" "" "" "0" "0" "1.017" "1.015" "1.154" "1.085" "1.077" "1.181" "1.038" "1.038" "1.017" "222.5" "226.1" "225.8" "256.7" "241.3" "239.6" "262.8" "231.0" "230.8" "226.2" "" "" "" "" "" "" "" "" "" "" "208.4" "187.1" "209.6" "198.5" "205.7" "228.9" "240.1" "205.1" "230.8" "217.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2850205802309277585" "False" "High" "IsMasterProtein" "Q96DE0" "U8 snoRNA-decapping enzyme OS=Homo sapiens OX=9606 GN=NUDT16 PE=1 SV=2" "0.000" "False" "9.654" "15" "3" "3" "2" "195" "21.3" "6.89" "12.16" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "131870" "ENSG00000198585" "NUDT16" "B4E3B4; E9PED4; F5GYJ1; hsa:131870; Q96DE0; Q96N82" "" "Phosphate bond hydrolysis by NUDT proteins" "1" "0" "0.924" "0.970" "1.004" "0.930" "0.939" "0.962" "0.915" "0.911" "0.982" "277.6" "256.4" "269.4" "278.7" "258.3" "260.8" "267.1" "254.0" "252.8" "272.7" "" "" "" "" "" "" "" "" "" "" "260.1" "212.2" "250.1" "215.5" "220.1" "249.1" "244.1" "225.5" "252.8" "262.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1450891647387080638" "False" "High" "IsMasterProtein" "Q9BUL8" "Programmed cell death protein 10 OS=Homo sapiens OX=9606 GN=PDCD10 PE=1 SV=1" "0.000" "False" "9.648" "14" "3" "4" "3" "212" "24.7" "8.19" "12.91" "3" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf06840, Pf20929" "11235" "ENSG00000114209" "PDCD10" "A8K515; D3DNN5; hsa:11235; O14811; Q9BUL8" "" "" "0" "0" "1.028" "1.035" "1.036" "1.059" "1.039" "1.005" "1.053" "1.057" "1.051" "755.3" "776.7" "781.5" "782.4" "799.9" "784.4" "759.2" "795.1" "798.1" "793.8" "" "" "" "" "" "" "" "" "" "" "707.7" "642.7" "725.5" "604.9" "681.8" "749.4" "693.7" "706.0" "798.1" "764.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3387955691257056682" "False" "High" "IsMasterProtein" "O43318" "Mitogen-activated protein kinase kinase kinase 7 OS=Homo sapiens OX=9606 GN=MAP3K7 PE=1 SV=1" "0.000" "False" "9.639" "5" "3" "3" "3" "606" "67.2" "7.11" "8.24" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf07714" "6885" "ENSG00000135341" "MAP3K7" "B2RE27; E1P523; hsa:6885; O43317; O43318; O43319; Q5TDN2; Q5TDN3; Q5TDT7; Q9NTR3; Q9NZ70" "IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; Fas ligand pathway and stress induction of heat shock proteins; Wnt signaling pathway; IL6 signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; Angiopoietin-like protein 8 regulatory pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; miRNA role in immune response in sepsis; Signal transduction through IL1R; Measles virus infection; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ca2+ pathway; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1-dependent IKK and NF-kappa-B activation ; TNFR1-induced NF-kappa-B signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway" "50" "0" "0.965" "0.970" "0.979" "1.076" "0.975" "0.980" "1.045" "0.935" "1.017" "374.5" "361.5" "363.1" "366.5" "402.9" "365.0" "367.1" "391.2" "350.2" "381.1" "" "" "" "" "" "" "" "" "" "" "350.9" "299.1" "337.1" "283.3" "343.5" "348.8" "335.5" "347.4" "350.2" "366.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3553931004733427798" "False" "High" "IsMasterProtein" "P62306" "Small nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=SNRPF PE=1 SV=1" "0.000" "False" "9.629" "24" "2" "6" "2" "86" "9.7" "4.67" "18.01" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "6636" "ENSG00000139343" "SNRPF" "A2VCR2; B2R498; hsa:6636; P62306; Q15356; Q6IBQ1; Q6P4I0" "mRNA processing" "snRNP Assembly; mRNA Splicing - Major Pathway; RNA Polymerase II Transcription Termination; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "1.046" "0.961" "0.909" "0.948" "0.888" "0.962" "0.975" "0.841" "0.876" "307.2" "321.2" "295.4" "279.1" "291.2" "272.8" "295.7" "299.5" "258.4" "269.0" "" "" "" "" "" "" "" "" "" "" "287.8" "265.8" "274.2" "215.8" "248.2" "260.7" "270.2" "265.9" "258.4" "259.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7633283186484640293" "False" "High" "IsMasterProtein" "Q06547" "GA-binding protein subunit beta-1 OS=Homo sapiens OX=9606 GN=GABPB1 PE=1 SV=2" "0.000" "False" "9.623" "6" "3" "6" "3" "395" "42.5" "4.86" "20.65" "3" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf12796" "2553" "ENSG00000104064" "GABPB1" "A8IE52; hsa:2553; Q06545; Q06547; Q12940; Q12941; Q12942; Q8IYD0" "Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression" "" "3" "0" "0.958" "0.935" "0.943" "0.964" "1.000" "1.035" "0.979" "0.946" "0.981" "836.8" "801.4" "782.5" "788.8" "806.5" "836.4" "866.5" "818.9" "792.0" "820.9" "" "" "" "" "" "" "" "" "" "" "784.1" "663.2" "726.5" "609.8" "687.5" "799.1" "791.7" "727.1" "792.0" "790.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8573575756283577734" "False" "High" "IsMasterProtein" "Q8TEH3" "DENN domain-containing protein 1A OS=Homo sapiens OX=9606 GN=DENND1A PE=1 SV=2" "0.000" "False" "9.617" "2" "2" "4" "2" "1009" "110.5" "6.96" "11.89" "2" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf02141, Pf03455, Pf03456" "57706" "ENSG00000119522" "DENND1A" "A8MZA3; B1AM80; B7Z3C8; B7Z669; D3PFD3; hsa:57706; Q05C88; Q5VWF0; Q6PJZ5; Q8IVD6; Q8TEH3; Q9H796" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.064" "0.912" "1.167" "1.052" "1.042" "1.154" "1.050" "0.906" "1.075" "91.1" "97.0" "83.1" "106.4" "95.9" "94.9" "105.2" "95.7" "82.6" "98.0" "" "" "" "" "" "" "" "" "" "" "85.4" "80.2" "77.2" "82.2" "81.8" "90.7" "96.1" "85.0" "82.6" "94.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1941330484708974901" "False" "High" "IsMasterProtein" "P18621" "Large ribosomal subunit protein uL22 OS=Homo sapiens OX=9606 GN=RPL17 PE=1 SV=3" "0.000" "False" "9.606" "16" "3" "5" "2" "184" "21.4" "10.17" "18.73" "3" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00237" "6139" "ENSG00000265681" "RPL17" "B2R4H3; B4E3C2; B5ME31; hsa:6139; J3QL51; P18621; Q3KQW2; Q6NZ54; Q7M4M5" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.978" "1.008" "0.957" "1.039" "1.016" "0.987" "0.980" "0.938" "1.042" "803.0" "785.4" "809.5" "768.3" "834.0" "815.8" "792.7" "787.2" "753.4" "836.5" "" "" "" "" "" "" "" "" "" "" "752.4" "649.9" "751.5" "593.9" "710.8" "779.4" "724.3" "698.9" "753.4" "805.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5652857945915371988" "False" "High" "IsMasterProtein" "Q9BQ69" "ADP-ribose glycohydrolase MACROD1 OS=Homo sapiens OX=9606 GN=MACROD1 PE=1 SV=2" "0.000" "False" "9.604" "12" "3" "3" "3" "325" "35.5" "9.51" "12.00" "3" "protein metabolism;other metabolic processes;stress response" "nucleus" "other molecular function" "Pf01661" "28992" "ENSG00000133315" "MACROD1" "hsa:28992; Q9BQ69; Q9UH96" "" "" "0" "0" "1.015" "1.048" "1.003" "1.073" "1.070" "1.066" "1.022" "1.058" "1.160" "360.4" "365.9" "377.5" "361.4" "386.6" "385.6" "384.0" "368.2" "381.3" "417.9" "" "" "" "" "" "" "" "" "" "" "337.7" "302.8" "350.5" "279.4" "329.5" "368.4" "350.9" "326.9" "381.3" "402.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "115101743397248701" "False" "High" "IsMasterProtein" "Q15528" "Mediator of RNA polymerase II transcription subunit 22 OS=Homo sapiens OX=9606 GN=MED22 PE=1 SV=2" "0.000" "False" "9.600" "17" "3" "3" "3" "200" "22.2" "4.68" "9.99" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf06179" "6837" "ENSG00000148297; ENSG00000281022" "MED22" "B3KW83; B3KWX4; hsa:6837; O76072; Q15528; Q5T8U0" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "3" "0" "1.095" "0.949" "1.059" "1.035" "0.998" "0.931" "1.049" "1.000" "1.048" "228.8" "250.4" "217.1" "242.4" "236.9" "228.4" "212.9" "239.9" "228.8" "239.8" "" "" "" "" "" "" "" "" "" "" "214.4" "207.2" "201.6" "187.4" "201.9" "218.2" "194.6" "213.0" "228.8" "230.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7159093635266280091" "False" "High" "IsMasterProtein" "O95295" "SNARE-associated protein Snapin OS=Homo sapiens OX=9606 GN=SNAPIN PE=1 SV=1" "0.000" "False" "9.588" "24" "3" "5" "3" "136" "14.9" "9.31" "12.31" "3" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf14712" "23557" "ENSG00000143553" "SNAPIN" "D3DV56; hsa:23557; O95295; Q5SXU8" "Alstrom syndrome" "Golgi Associated Vesicle Biogenesis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4000962258629935056" "False" "High" "IsMasterProtein" "P62847" "Small ribosomal subunit protein eS24 OS=Homo sapiens OX=9606 GN=RPS24 PE=1 SV=1" "0.000" "False" "9.581" "30" "4" "5" "4" "133" "15.4" "10.78" "13.57" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01282" "6229" "ENSG00000138326" "RPS24" "E7EPK6; hsa:6229; P16632; P62847; Q5T0P7; Q5T0P8; Q7Z3D1" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "1.106" "1.123" "0.937" "1.080" "1.093" "1.142" "1.164" "1.170" "1.036" "264.6" "292.6" "297.1" "247.9" "285.6" "289.2" "302.2" "307.9" "309.5" "274.2" "" "" "" "" "" "" "" "" "" "" "247.9" "242.1" "275.8" "191.7" "243.5" "276.3" "276.2" "273.4" "309.5" "264.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8564322409184755345" "False" "High" "IsMasterProtein" "Q9Y4K3" "TNF receptor-associated factor 6 OS=Homo sapiens OX=9606 GN=TRAF6 PE=1 SV=1" "0.000" "False" "9.569" "6" "3" "4" "3" "522" "59.5" "6.44" "15.46" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02176, Pf13923, Pf18048, Pf21355" "7189" "ENSG00000175104" "TRAF6" "A6NKI7; A8KAB3; D3DR16; hsa:7189; Q8NEH5; Q9Y4K3" "IL-1 signaling pathway; RANKL/RANK signaling pathway; IL-17 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Melatonin metabolism and effects; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NF-kB survival signaling; Interleukin-1 induced activation of NF-kB; TGF-beta signaling pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; MYD88 distinct input-output pathway; ApoE and miR-146 in inflammation and atherosclerosis; Oxidative damage response; Fibrin complement receptor 3 signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; miRNA role in immune response in sepsis; LTF danger signal response pathway; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; Clock-controlled autophagy in bone metabolism; Induction of autophagy and toll-like receptor signaling pathways by graphene oxide ; T-cell receptor signaling pathway; Toll-like receptor signaling pathway" "Ub-specific processing proteases; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; PIP3 activates AKT signaling; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; SARS-CoV-1 activates/modulates innate immune responses; Alpha-protein kinase 1 signaling pathway; Ovarian tumor domain proteases; TRAF6 mediated IRF7 activation; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "78" "0" "1.013" "1.053" "1.301" "1.115" "0.994" "1.221" "1.113" "1.099" "1.175" "118.2" "119.7" "124.5" "153.8" "131.8" "117.5" "144.2" "131.5" "129.9" "138.8" "" "" "" "" "" "" "" "" "" "" "110.7" "99.1" "115.5" "118.9" "112.3" "112.3" "131.8" "116.8" "129.9" "133.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2490332894624900384" "False" "High" "IsMasterProtein" "Q92574" "Hamartin OS=Homo sapiens OX=9606 GN=TSC1 PE=1 SV=2" "0.000" "False" "9.568" "2" "3" "5" "3" "1164" "129.7" "6.47" "13.62" "3" "cell adhesion;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04388" "7248" "ENSG00000165699" "TSC1" "B7Z897; hsa:7248; Q5VVN5; Q92574" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Glioblastoma signaling pathways; Nanoparticle triggered autophagic cell death; Polycystic kidney disease pathway; Wnt signaling pathway; BDNF-TrkB signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; CAMKK2 pathway; Pleural mesothelioma; DYRK1A involvement regarding cell proliferation in brain development" "TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; TBC/RABGAPs; Inhibition of TSC complex formation by PKB" "27" "0" "0.974" "0.946" "0.988" "0.977" "0.972" "0.946" "0.898" "0.869" "0.999" "473.5" "461.0" "447.7" "467.8" "462.8" "460.1" "448.1" "425.3" "411.4" "472.8" "" "" "" "" "" "" "" "" "" "" "443.6" "381.5" "415.6" "361.6" "394.5" "439.5" "409.4" "377.6" "411.4" "455.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1591325911363533533" "False" "High" "IsMasterProtein" "Q8NFV4" "sn-1-specific diacylglycerol lipase ABHD11 OS=Homo sapiens OX=9606 GN=ABHD11 PE=1 SV=2" "0.000" "False" "9.555" "10" "3" "3" "3" "306" "33.7" "9.19" "10.11" "3" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00561" "83451" "ENSG00000106077" "ABHD11" "H7BYM8; hsa:83451; Q6PJU0; Q8N722; Q8N723; Q8NFV2; Q8NFV3; Q8NFV4; Q9HBS8" "7q11.23 copy number variation syndrome" "" "1" "0" "1.009" "0.985" "1.122" "0.965" "0.938" "1.035" "0.956" "0.974" "0.967" "532.0" "536.9" "523.8" "596.9" "513.1" "499.1" "550.8" "508.4" "518.0" "514.3" "" "" "" "" "" "" "" "" "" "" "498.5" "444.3" "486.2" "461.4" "437.4" "476.8" "503.3" "451.4" "518.0" "495.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6607241123372228531" "False" "High" "IsMasterProtein" "Q13017" "Rho GTPase-activating protein 5 OS=Homo sapiens OX=9606 GN=ARHGAP5 PE=1 SV=2" "0.000" "False" "9.550" "2" "4" "4" "4" "1502" "172.4" "6.62" "12.07" "4" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00620, Pf01846, Pf16512, Pf19518" "394" "ENSG00000100852" "ARHGAP5" "A1L375; A1L376; A8KAA1; D3DS89; D3DS90; hsa:394; Q05BE8; Q05BU8; Q13017; Q59ER0; Q6DHZ3" "Focal adhesion" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOJ GTPase cycle; RHOC GTPase cycle; RND2 GTPase cycle; RHOA GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle" "15" "0" "1.034" "1.004" "1.161" "1.109" "1.026" "1.117" "1.045" "1.022" "1.071" "308.7" "319.2" "309.9" "358.5" "342.5" "316.7" "344.7" "322.7" "315.6" "330.5" "" "" "" "" "" "" "" "" "" "" "289.2" "264.1" "287.7" "277.1" "291.9" "302.6" "315.0" "286.5" "315.6" "318.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5966605329502245695" "False" "High" "IsMasterProtein" "P10599" "Thioredoxin OS=Homo sapiens OX=9606 GN=TXN PE=1 SV=3" "0.000" "False" "9.542" "30" "3" "11" "3" "105" "11.7" "4.92" "37.04" "3" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00085" "7295" "ENSG00000136810" "TXN" "B1ALW1; hsa:7295; O60744; P10599; Q53X69; Q96KI3; Q9UDG5" "Selenium micronutrient network; Folic acid network; Selenium micronutrient network ; Folic acid network; Selenium micronutrient network; TNF-alpha signaling pathway; Complement system; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling; TAR syndrome" "Detoxification of Reactive Oxygen Species; Oxidative Stress Induced Senescence; TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates; NFE2L2 regulating anti-oxidant/detoxification enzymes; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Regulation of FOXO transcriptional activity by acetylation; Protein repair" "20" "0" "1.012" "0.983" "1.065" "0.989" "0.967" "1.025" "0.987" "0.943" "0.965" "593.3" "600.2" "583.4" "632.0" "586.5" "573.4" "608.4" "585.4" "559.3" "572.8" "" "" "" "" "" "" "" "" "" "" "555.9" "496.6" "541.6" "488.6" "500.0" "547.8" "555.9" "519.8" "559.3" "551.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4404494894943398685" "False" "High" "IsMasterProtein" "Q6P5R6" "Ribosomal protein eL22-like OS=Homo sapiens OX=9606 GN=RPL22L1 PE=1 SV=2" "0.000" "False" "9.534" "28" "3" "3" "3" "122" "14.6" "9.38" "11.57" "3" "protein metabolism;other metabolic processes" "translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01776" "200916" "ENSG00000163584" "RPL22L1" "hsa:200916; Q32Q77; Q6P5R6" "" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "13" "0" "1.089" "1.135" "1.142" "1.164" "1.205" "1.221" "1.242" "1.311" "1.147" "313.0" "340.8" "355.1" "357.3" "364.4" "377.1" "382.1" "388.9" "410.4" "359.0" "" "" "" "" "" "" "" "" "" "" "293.3" "282.0" "329.7" "276.2" "310.6" "360.3" "349.2" "345.3" "410.4" "345.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-218313334757402260" "False" "High" "IsMasterProtein" "A6NFI3" "Zinc finger protein 316 OS=Homo sapiens OX=9606 GN=ZNF316 PE=1 SV=1" "0.000" "False" "9.532" "4" "5" "6" "5" "1004" "108.4" "5.31" "8.02" "5" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "100131017" "ENSG00000205903" "ZNF316" "A6NFI3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1227162241055397784" "False" "High" "IsMasterProtein" "Q9H0W8" "Nonsense-mediated mRNA decay factor SMG9 OS=Homo sapiens OX=9606 GN=SMG9 PE=1 SV=1" "0.000" "False" "9.520" "8" "3" "3" "3" "520" "57.6" "7.01" "9.76" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol" "other molecular function" "" "56006" "ENSG00000105771" "SMG9" "hsa:56006; O60429; Q9H0W8; Q9H9A9" "" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "1" "0" "1.175" "0.975" "1.337" "1.154" "0.916" "1.240" "0.939" "0.942" "1.076" "93.4" "109.7" "91.1" "124.9" "107.8" "85.5" "115.8" "87.7" "88.0" "100.4" "" "" "" "" "" "" "" "" "" "" "87.5" "90.8" "84.5" "96.5" "91.8" "81.7" "105.8" "77.9" "88.0" "96.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7069334460136082352" "False" "High" "IsMasterProtein" "Q9Y4P8" "WD repeat domain phosphoinositide-interacting protein 2 OS=Homo sapiens OX=9606 GN=WIPI2 PE=1 SV=1" "0.000" "False" "9.513" "7" "4" "5" "4" "454" "49.4" "6.46" "16.17" "4" "cell organization and biogenesis;other metabolic processes;stress response" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf21032" "26100" "ENSG00000157954" "WIPI2" "B3KNC2; hsa:26100; Q5MNZ8; Q6FI96; Q75L50; Q96IE4; Q9Y364; Q9Y4P8" "Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "6" "0" "1.030" "1.023" "0.940" "0.998" "0.977" "1.040" "0.915" "0.969" "0.980" "720.5" "742.0" "737.0" "677.7" "718.9" "703.9" "749.2" "659.6" "698.3" "706.5" "" "" "" "" "" "" "" "" "" "" "675.1" "614.0" "684.2" "523.9" "612.8" "672.5" "684.5" "585.6" "698.3" "680.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8814237146634600983" "False" "High" "IsMasterProtein" "Q15642" "Cdc42-interacting protein 4 OS=Homo sapiens OX=9606 GN=TRIP10 PE=1 SV=3" "0.000" "False" "9.509" "6" "4" "6" "4" "601" "68.3" "5.73" "10.89" "4" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00611" "9322" "ENSG00000125733" "TRIP10" "B2R8A6; B7WP22; D6W645; hsa:9322; O15184; Q15642; Q53G22; Q5TZN1; Q6FI24; Q8NFL1; Q8TCY1; Q8TDX3; Q96RJ1" "Angiopoietin-like protein 8 regulatory pathway" "RHOQ GTPase cycle; Clathrin-mediated endocytosis" "3" "0" "1.035" "0.987" "1.104" "1.036" "0.980" "1.041" "0.988" "0.990" "0.961" "438.8" "454.0" "433.0" "484.3" "454.6" "430.1" "456.9" "433.3" "434.3" "421.5" "" "" "" "" "" "" "" "" "" "" "411.1" "375.7" "402.0" "374.4" "387.5" "410.9" "417.5" "384.7" "434.3" "405.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8554271472140898461" "False" "High" "IsMasterProtein" "Q8N584" "Tetratricopeptide repeat protein 39C OS=Homo sapiens OX=9606 GN=TTC39C PE=1 SV=2" "0.000" "False" "9.497" "6" "4" "4" "4" "583" "65.8" "6.99" "11.36" "4" "cell organization and biogenesis;developmental processes" "" "" "Pf10300" "125488" "ENSG00000168234" "TTC39C" "B7WP63; hsa:125488; J3QRR1; Q0VAJ2; Q8N284; Q8N584" "" "" "0" "0" "0.952" "1.012" "0.952" "0.932" "1.023" "0.894" "0.874" "0.922" "0.946" "668.7" "636.9" "676.6" "636.7" "623.2" "683.9" "597.7" "584.6" "616.7" "632.5" "" "" "" "" "" "" "" "" "" "" "626.5" "527.0" "628.1" "492.2" "531.2" "653.4" "546.1" "519.1" "616.7" "609.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8587567595163417034" "False" "High" "IsMasterProtein" "Q9UIQ6" "Leucyl-cystinyl aminopeptidase OS=Homo sapiens OX=9606 GN=LNPEP PE=1 SV=3" "0.000" "False" "9.496" "3" "3" "4" "3" "1025" "117.3" "5.73" "10.87" "3" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "4012" "ENSG00000113441" "LNPEP" "hsa:4012; O00769; Q15145; Q59H76; Q9TNQ2; Q9TNQ3; Q9UIQ6; Q9UIQ7" "" "Antigen processing: Ubiquitination & Proteasome degradation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Endosomal/Vacuolar pathway" "3" "0" "0.992" "0.894" "1.160" "1.085" "0.952" "1.081" "1.035" "0.961" "1.046" "169.9" "168.5" "151.9" "197.1" "184.4" "161.7" "183.8" "175.9" "163.3" "177.8" "" "" "" "" "" "" "" "" "" "" "159.2" "139.4" "141.1" "152.4" "157.2" "154.5" "167.9" "156.2" "163.3" "171.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6504309841328491303" "False" "High" "IsMasterProtein" "Q8NAF0" "Zinc finger protein 579 OS=Homo sapiens OX=9606 GN=ZNF579 PE=1 SV=2" "0.000" "False" "9.491" "5" "3" "4" "3" "562" "60.5" "8.69" "11.94" "3" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "163033" "ENSG00000218891" "ZNF579" "hsa:163033; Q8NAF0" "" "" "0" "0" "1.082" "0.990" "1.007" "0.974" "0.929" "0.994" "0.997" "0.922" "0.933" "564.2" "610.6" "558.4" "568.2" "549.6" "524.3" "560.9" "562.4" "520.0" "526.3" "" "" "" "" "" "" "" "" "" "" "528.7" "505.3" "518.4" "439.3" "468.5" "500.9" "512.5" "499.3" "520.0" "506.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6469801124856573436" "False" "High" "IsMasterProtein" "P36404" "ADP-ribosylation factor-like protein 2 OS=Homo sapiens OX=9606 GN=ARL2 PE=1 SV=4" "0.000" "False" "9.488" "11" "2" "4" "2" "184" "20.9" "6.34" "10.17" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00025" "402" "ENSG00000213465" "ARL2" "G3V184; hsa:402; P36404; Q9BUK8" "Joubert syndrome" "Post-chaperonin tubulin folding pathway; Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; RAS processing" "4" "0" "1.057" "1.145" "1.115" "1.064" "1.246" "1.118" "1.156" "1.062" "1.051" "145.9" "154.2" "167.0" "162.7" "155.3" "181.7" "163.0" "168.7" "154.9" "153.3" "" "" "" "" "" "" "" "" "" "" "136.7" "127.6" "155.0" "125.7" "132.3" "173.6" "149.0" "149.7" "154.9" "147.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-381937601164646059" "False" "High" "IsMasterProtein" "Q15257" "Serine/threonine-protein phosphatase 2A activator OS=Homo sapiens OX=9606 GN=PTPA PE=1 SV=3" "0.000" "False" "9.483" "11" "4" "5" "4" "358" "40.6" "5.94" "13.96" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf03095" "5524" "ENSG00000119383" "PTPA" "A2A347; A9IZU4; B4DXM4; hsa:5524; Q15257; Q15258; Q53GZ3; Q5TZQ2; Q9BUK1; Q9NNZ7; Q9NNZ8; Q9NNZ9" "Interleukin-11 signaling pathway; Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Wnt signaling pathway and pluripotency; Netrin-UNC5B signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "" "7" "0" "1.090" "1.141" "1.196" "1.054" "1.060" "1.144" "1.173" "1.103" "1.061" "79.0" "86.1" "90.2" "94.5" "83.3" "83.8" "90.4" "92.7" "87.2" "83.9" "" "" "" "" "" "" "" "" "" "" "74.1" "71.3" "83.7" "73.1" "71.0" "80.0" "82.6" "82.3" "87.2" "80.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2715683272122769400" "False" "High" "IsMasterProtein" "Q14197" "Large ribosomal subunit protein mL62 OS=Homo sapiens OX=9606 GN=MRPL58 PE=1 SV=1" "0.000" "False" "9.476" "14" "3" "4" "3" "206" "23.6" "10.07" "14.37" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "plasma membrane;other membranes;mitochondrion;translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "Pf00472" "3396" "ENSG00000167862" "MRPL58" "B2RAD1; hsa:3396; Q14197; Q53HM7; Q53Y11" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.044" "1.063" "0.994" "1.080" "1.085" "1.028" "1.067" "1.070" "1.082" "533.9" "557.2" "567.5" "530.8" "576.8" "579.3" "549.0" "569.7" "571.4" "577.5" "" "" "" "" "" "" "" "" "" "" "500.3" "461.1" "526.9" "410.3" "491.7" "553.4" "501.6" "505.8" "571.4" "556.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8611257715597886633" "False" "High" "IsMasterProtein" "Q15555" "Microtubule-associated protein RP/EB family member 2 OS=Homo sapiens OX=9606 GN=MAPRE2 PE=1 SV=1" "0.000" "False" "9.471" "10" "4" "4" "4" "327" "37.0" "5.57" "10.73" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf03271" "10982" "ENSG00000166974" "MAPRE2" "B2RE21; B3KR39; B4DJV4; B7Z2L3; E9PHR3; F5H1V8; G5E9I6; hsa:10982; Q15555; Q9UQ33" "Ciliary landscape" "" "1" "0" "0.930" "0.951" "0.862" "0.953" "0.941" "0.817" "0.908" "0.861" "0.937" "1111.2" "1033.6" "1056.5" "957.9" "1059.5" "1046.1" "908.3" "1008.7" "956.2" "1040.8" "" "" "" "" "" "" "" "" "" "" "1041.2" "855.3" "980.9" "740.5" "903.1" "999.4" "830.0" "895.6" "956.2" "1002.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5454865549219062540" "False" "High" "IsMasterProtein" "P14859" "POU domain, class 2, transcription factor 1 OS=Homo sapiens OX=9606 GN=POU2F1 PE=1 SV=2" "0.000" "False" "9.465" "4" "3" "3" "3" "743" "76.4" "6.81" "10.51" "3" "other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00157, Pf19536" "5451" "ENSG00000143190" "POU2F1" "B1AL91; B1AL93; B4E029; hsa:5451; J3KP77; P14859; Q5TBT7; Q6PK46; Q8NEU9; Q9BPV1" "Integrated cancer pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interleukin-4 and Interleukin-13 signaling" "6" "0" "0.901" "0.947" "0.992" "0.987" "0.929" "0.943" "0.983" "0.951" "0.959" "498.4" "449.1" "472.1" "494.3" "492.1" "463.2" "470.1" "490.0" "473.9" "478.2" "" "" "" "" "" "" "" "" "" "" "467.0" "371.6" "438.2" "382.1" "419.5" "442.5" "429.6" "435.1" "473.9" "460.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6265096555801149049" "False" "High" "IsMasterProtein" "P06132" "Uroporphyrinogen decarboxylase OS=Homo sapiens OX=9606 GN=UROD PE=1 SV=2" "0.000" "False" "9.463" "9" "4" "4" "4" "367" "40.8" "6.14" "10.34" "4" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01208" "7389" "ENSG00000126088" "UROD" "A8K762; hsa:7389; P06132; Q16863; Q16883; Q53YB8; Q53ZP6; Q6IB28; Q9BUZ0" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "3" "0" "0.860" "0.884" "1.064" "0.995" "0.931" "1.019" "0.878" "0.858" "0.972" "410.8" "353.4" "363.2" "437.0" "408.8" "382.6" "418.8" "360.5" "352.4" "399.3" "" "" "" "" "" "" "" "" "" "" "384.9" "292.4" "337.2" "337.8" "348.4" "365.6" "382.7" "320.1" "352.4" "384.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8633064063620321085" "False" "High" "IsMasterProtein" "Q6PGP7" "Superkiller complex protein 3 OS=Homo sapiens OX=9606 GN=SKIC3 PE=1 SV=1" "0.000" "False" "9.462" "2" "4" "4" "4" "1564" "175.4" "7.53" "10.52" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf13181, Pf13432, Pf14559" "9652" "ENSG00000198677" "SKIC3" "hsa:9652; O15077; Q6PGP7; Q6PJI3" "" "mRNA decay by 3' to 5' exoribonuclease" "1" "0" "0.939" "0.900" "0.913" "0.961" "1.008" "0.969" "0.953" "1.009" "0.954" "543.2" "509.9" "488.6" "496.0" "521.8" "547.7" "526.4" "517.8" "548.1" "518.2" "" "" "" "" "" "" "" "" "" "" "509.0" "421.9" "453.6" "383.4" "444.7" "523.3" "481.0" "459.7" "548.1" "499.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1176830711489117496" "False" "High" "IsMasterProtein" "Q7L1V2" "Vacuolar fusion protein MON1 homolog B OS=Homo sapiens OX=9606 GN=MON1B PE=1 SV=1" "0.000" "False" "9.449" "7" "4" "5" "4" "547" "59.2" "6.29" "8.52" "4" "transport;other biological processes" "other cytoplasmic organelle;other cell component" "" "Pf19036, Pf19037, Pf19038" "22879" "ENSG00000103111" "MON1B" "B4DDZ0; hsa:22879; O94949; Q7L1V2" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "0.881" "1.041" "1.067" "1.148" "0.970" "1.020" "1.015" "1.014" "1.089" "263.4" "232.1" "274.1" "281.1" "302.5" "255.4" "268.8" "267.3" "267.1" "287.0" "" "" "" "" "" "" "" "" "" "" "246.8" "192.1" "254.5" "217.3" "257.9" "244.0" "245.6" "237.4" "267.1" "276.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4736314326613788604" "False" "High" "IsMasterProtein" "P62277" "Small ribosomal subunit protein uS15 OS=Homo sapiens OX=9606 GN=RPS13 PE=1 SV=2" "0.000" "False" "9.445" "25" "4" "4" "4" "151" "17.2" "10.54" "11.68" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00312, Pf08069" "6207" "ENSG00000110700" "RPS13" "B2R549; hsa:6207; P19116; P62277; Q02546; Q29200; Q498Y0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Selenocysteine synthesis; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.006" "0.984" "1.122" "1.104" "1.040" "1.293" "1.117" "1.096" "1.112" "189.7" "190.8" "186.7" "212.8" "209.3" "197.3" "245.2" "211.8" "207.9" "210.8" "" "" "" "" "" "" "" "" "" "" "177.7" "157.9" "173.3" "164.5" "178.4" "188.5" "224.1" "188.1" "207.9" "203.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5258302069466510735" "False" "High" "IsMasterProtein" "P56279" "T-cell leukemia/lymphoma protein 1A OS=Homo sapiens OX=9606 GN=TCL1A PE=1 SV=1" "0.000" "False" "9.441" "32" "4" "8" "4" "114" "13.5" "5.11" "18.04" "4" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01840" "8115" "ENSG00000100721" "TCL1A" "hsa:8115; P56279; Q6IBK7" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "" "2" "0" "0.987" "0.973" "1.015" "0.962" "1.002" "0.959" "0.975" "0.908" "0.916" "1297.3" "1280.2" "1261.7" "1316.8" "1247.8" "1299.5" "1243.7" "1264.7" "1177.7" "1188.5" "" "" "" "" "" "" "" "" "" "" "1215.5" "1059.3" "1171.3" "1017.9" "1063.6" "1241.6" "1136.4" "1122.9" "1177.7" "1144.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2974578878725693910" "False" "High" "IsMasterProtein" "P45984" "Mitogen-activated protein kinase 9 OS=Homo sapiens OX=9606 GN=MAPK9 PE=1 SV=2" "0.000" "False" "9.437" "7" "3" "5" "2" "424" "48.1" "5.63" "14.34" "3" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5601" "ENSG00000050748" "MAPK9" "A8K0S3; B5BU66; B5M0B4; D3DWQ8; D3DWQ9; hsa:5601; P45984; Q15708; Q15710; Q15711; Q8N5C5" "IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling pathway; Interleukin-1 (IL-1) structural pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Wnt signaling pathway and pluripotency; Splicing factor NOVA regulated synaptic proteins; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Regulatory circuits of the STAT3 signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; CCL18 signaling pathway; Familial partial lipodystrophy; Alzheimer's disease; GDNF signaling; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; 5q35 copy number variation; 13q12.12 copy number variation; TGF-beta receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Toll-like receptor signaling pathway" "Oxidative Stress Induced Senescence; Signaling by ALK fusions and activated point mutants; FCERI mediated MAPK activation; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Activation of the AP-1 family of transcription factors" "66" "0" "1.040" "1.047" "1.141" "1.186" "1.060" "1.086" "1.099" "0.999" "1.088" "128.8" "134.0" "134.9" "147.0" "152.8" "136.6" "139.9" "141.6" "128.7" "140.2" "" "" "" "" "" "" "" "" "" "" "120.7" "110.9" "125.2" "113.7" "130.2" "130.5" "127.8" "125.7" "128.7" "135.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8414928618058390258" "False" "High" "IsMasterProtein" "Q8N9N2" "Activating signal cointegrator 1 complex subunit 1 OS=Homo sapiens OX=9606 GN=ASCC1 PE=1 SV=1" "0.000" "False" "9.432" "8" "4" "4" "4" "400" "45.5" "5.54" "11.71" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00013, Pf10469" "51008" "ENSG00000138303" "ASCC1" "hsa:51008; Q5SW06; Q5SW07; Q8N9N2; Q96EI8; Q9Y307" "Neuroinflammation" "ALKBH3 mediated reversal of alkylation damage" "2" "0" "1.016" "1.081" "1.043" "0.987" "1.018" "1.073" "1.069" "1.062" "1.024" "423.7" "430.3" "458.1" "441.8" "418.0" "431.5" "454.8" "452.9" "449.9" "433.8" "" "" "" "" "" "" "" "" "" "" "397.0" "356.1" "425.3" "341.5" "356.3" "412.3" "415.5" "402.2" "449.9" "417.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8905060599663970094" "False" "High" "IsMasterProtein" "Q9Y5K8" "V-type proton ATPase subunit D OS=Homo sapiens OX=9606 GN=ATP6V1D PE=1 SV=1" "0.000" "False" "9.431" "13" "3" "4" "3" "247" "28.2" "9.36" "13.16" "3" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity" "Pf01813" "51382" "ENSG00000100554" "ATP6V1D" "B2RE33; hsa:51382; Q9Y5K8; Q9Y688" "Proximal tubule transport" "Neutrophil degranulation; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "7" "0" "0.958" "1.003" "1.008" "1.045" "1.041" "1.000" "0.958" "0.963" "1.017" "824.7" "790.0" "827.1" "831.4" "861.5" "858.6" "824.6" "789.9" "794.1" "838.9" "" "" "" "" "" "" "" "" "" "" "772.7" "653.8" "767.8" "642.7" "734.3" "820.3" "753.4" "701.3" "794.1" "807.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3617199734258832058" "False" "High" "IsMasterProtein" "Q9BZQ8" "Protein Niban 1 OS=Homo sapiens OX=9606 GN=NIBAN1 PE=1 SV=1" "0.000" "False" "9.424" "5" "3" "3" "3" "928" "103.1" "4.78" "13.63" "3" "stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "" "" "116496" "ENSG00000135842" "NIBAN1" "hsa:116496; Q2TTR2; Q5TEM8; Q8TEI5; Q9BZQ8; Q9H593; Q9H9Y8; Q9HCB9" "" "" "0" "0" "0.980" "1.094" "1.107" "0.997" "0.994" "0.999" "0.928" "0.959" "1.042" "238.4" "233.7" "260.8" "263.9" "237.5" "237.0" "238.2" "221.3" "228.5" "248.3" "" "" "" "" "" "" "" "" "" "" "223.3" "193.3" "242.1" "204.0" "202.5" "226.4" "217.7" "196.5" "228.5" "239.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3249380285139605434" "False" "High" "IsMasterProtein" "Q96CB9" "5-methylcytosine rRNA methyltransferase NSUN4 OS=Homo sapiens OX=9606 GN=NSUN4 PE=1 SV=2" "0.000" "False" "9.416" "8" "3" "3" "3" "384" "43.1" "8.18" "10.65" "3" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf01189" "387338" "ENSG00000117481" "NSUN4" "A8K6S6; B3KQ50; B4DHA4; hsa:387338; Q5TDF7; Q96AN8; Q96CB9; Q9HAJ8" "" "rRNA modification in the mitochondrion" "1" "0" "1.096" "1.016" "1.173" "1.148" "1.100" "1.101" "1.091" "1.049" "1.052" "200.3" "219.5" "203.4" "234.9" "230.0" "220.3" "220.5" "218.5" "210.1" "210.7" "" "" "" "" "" "" "" "" "" "" "187.7" "181.6" "188.8" "181.6" "196.0" "210.5" "201.5" "194.0" "210.1" "202.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5740436620154947735" "False" "High" "IsMasterProtein" "Q9BX68" "Adenosine 5'-monophosphoramidase HINT2 OS=Homo sapiens OX=9606 GN=HINT2 PE=1 SV=1" "0.000" "False" "9.408" "20" "3" "3" "3" "163" "17.2" "9.16" "9.38" "3" "other metabolic processes;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01230" "84681" "ENSG00000137133" "HINT2" "hsa:84681; Q5TCW3; Q9BX68" "" "RHOD GTPase cycle" "1" "0" "1.014" "0.950" "0.907" "1.042" "1.033" "0.966" "1.014" "0.930" "1.024" "329.5" "334.2" "313.2" "298.8" "343.4" "340.5" "318.2" "334.3" "306.4" "337.6" "" "" "" "" "" "" "" "" "" "" "308.8" "276.6" "290.7" "231.0" "292.7" "325.3" "290.8" "296.8" "306.4" "325.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3278234146555232268" "False" "High" "IsMasterProtein" "Q96BK5" "PIN2/TERF1-interacting telomerase inhibitor 1 OS=Homo sapiens OX=9606 GN=PINX1 PE=1 SV=2" "0.000" "False" "9.407" "10" "3" "5" "3" "328" "37.0" "9.60" "15.49" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01585" "54984" "ENSG00000254093; ENSG00000284764" "PINX1" "B2R9B1; hsa:54984; Q548A5; Q6QWG9; Q7Z7J8; Q96BK5; Q96QD7; Q9HBU7; Q9NWW2" "" "" "0" "0" "1.122" "1.090" "1.185" "1.276" "1.114" "1.417" "1.532" "1.428" "1.253" "288.0" "323.3" "314.1" "341.5" "367.6" "321.0" "408.3" "441.4" "411.3" "360.9" "" "" "" "" "" "" "" "" "" "" "269.9" "267.5" "291.6" "264.0" "313.4" "306.7" "373.1" "391.9" "411.3" "347.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-827121188594037217" "False" "High" "IsMasterProtein" "Q6P1R4" "tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like OS=Homo sapiens OX=9606 GN=DUS1L PE=1 SV=1" "0.000" "False" "9.404" "7" "3" "3" "3" "473" "53.2" "8.29" "10.41" "3" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf01207" "64118" "ENSG00000169718" "DUS1L" "A6NHV4; hsa:64118; Q6P1R4; Q96AI3" "" "" "0" "0" "0.993" "1.091" "1.075" "0.962" "0.969" "0.999" "0.964" "1.011" "1.028" "427.4" "424.6" "466.3" "459.3" "411.2" "414.3" "427.1" "411.9" "432.2" "439.2" "" "" "" "" "" "" "" "" "" "" "400.5" "351.3" "432.9" "355.1" "350.5" "395.8" "390.3" "365.7" "432.2" "422.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5697914900789617779" "False" "High" "IsMasterProtein" "Q7RTV0" "PHD finger-like domain-containing protein 5A OS=Homo sapiens OX=9606 GN=PHF5A PE=1 SV=1" "0.000" "False" "9.397" "27" "4" "5" "4" "110" "12.4" "8.41" "14.95" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03660" "84844" "ENSG00000100410" "PHF5A" "hsa:84844; Q7RTV0; Q9UH06" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.067" "1.042" "0.978" "0.985" "0.971" "1.029" "1.041" "1.036" "0.955" "1378.8" "1470.5" "1436.3" "1349.1" "1357.5" "1338.8" "1419.3" "1435.5" "1428.4" "1317.0" "" "" "" "" "" "" "" "" "" "" "1291.9" "1216.8" "1333.4" "1042.9" "1157.1" "1279.1" "1296.8" "1274.6" "1428.4" "1268.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4850217669682801799" "False" "High" "IsMasterProtein" "Q9NZD8" "Maspardin OS=Homo sapiens OX=9606 GN=SPG21 PE=1 SV=1" "0.000" "False" "9.395" "7" "2" "3" "2" "308" "34.9" "6.28" "8.01" "2" "signal transduction" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding" "Pf00561" "51324" "ENSG00000090487" "SPG21" "B4DW44; Q6ZMB6; Q9NZD8" "" "" "0" "0" "0.950" "0.968" "1.099" "1.032" "1.046" "0.966" "0.932" "0.960" "0.981" "358.2" "340.3" "346.9" "393.7" "369.8" "374.8" "345.8" "333.9" "343.7" "351.3" "" "" "" "" "" "" "" "" "" "" "335.6" "281.6" "322.0" "304.3" "315.2" "358.0" "316.0" "296.5" "343.7" "338.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1696656026908675474" "False" "High" "IsMasterProtein" "Q9BS40" "Latexin OS=Homo sapiens OX=9606 GN=LXN PE=1 SV=2" "0.000" "False" "9.392" "14" "3" "3" "3" "222" "25.7" "5.78" "9.46" "3" "stress response;other biological processes" "non-structural extracellular;other cell component" "enzyme regulator activity;other molecular function" "Pf06907, Pf20630" "56925" "ENSG00000079257" "LXN" "hsa:56925; Q96PN2; Q9BS40; Q9NQS6" "" "" "0" "0" "0.963" "0.933" "0.998" "0.997" "0.960" "0.922" "0.961" "0.881" "0.951" "712.0" "685.4" "664.5" "710.9" "709.5" "683.6" "656.7" "684.1" "627.4" "676.7" "" "" "" "" "" "" "" "" "" "" "667.1" "567.2" "616.9" "549.5" "604.8" "653.1" "600.0" "607.4" "627.4" "651.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-428002072210945893" "False" "High" "IsMasterProtein" "P52657" "Transcription initiation factor IIA subunit 2 OS=Homo sapiens OX=9606 GN=GTF2A2 PE=1 SV=1" "0.000" "False" "9.391" "28" "4" "6" "4" "109" "12.4" "6.62" "19.00" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02268, Pf02751" "2958" "ENSG00000140307" "GTF2A2" "A8MYQ7; hsa:2958; P52657; Q6FGB5" "Eukaryotic transcription initiation" "Estrogen-dependent gene expression; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "11" "0" "0.883" "0.930" "0.975" "0.931" "0.992" "0.932" "0.929" "0.934" "0.954" "1026.4" "905.9" "954.5" "1000.7" "955.6" "1018.5" "956.2" "953.1" "958.7" "978.9" "" "" "" "" "" "" "" "" "" "" "961.7" "749.6" "886.2" "773.6" "814.5" "973.1" "873.7" "846.3" "958.7" "942.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5064589920710455811" "False" "High" "IsMasterProtein" "O00635" "E3 ubiquitin-protein ligase TRIM38 OS=Homo sapiens OX=9606 GN=TRIM38 PE=1 SV=1" "0.000" "False" "9.388" "7" "3" "3" "3" "465" "53.4" "7.02" "9.10" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13765, Pf15227" "10475" "ENSG00000112343" "TRIM38" "B2R862; hsa:10475; O00635" "" "Interferon gamma signaling" "1" "0" "1.028" "1.031" "0.948" "1.054" "1.052" "0.987" "1.048" "1.049" "1.035" "289.7" "297.9" "298.5" "274.7" "305.4" "304.6" "285.9" "303.5" "303.8" "299.7" "" "" "" "" "" "" "" "" "" "" "271.4" "246.5" "277.2" "212.4" "260.3" "291.0" "261.3" "269.5" "303.8" "288.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2283979429673317137" "False" "High" "IsMasterProtein" "A6NIH7" "Protein unc-119 homolog B OS=Homo sapiens OX=9606 GN=UNC119B PE=1 SV=1" "0.000" "False" "9.387" "11" "3" "3" "3" "251" "28.1" "5.68" "9.43" "3" "cell organization and biogenesis;transport;developmental processes" "cytosol;other cell component" "other molecular function" "Pf05351" "84747" "ENSG00000175970" "UNC119B" "A6NIH7; hsa:84747" "" "Trafficking of myristoylated proteins to the cilium" "1" "0" "1.011" "1.042" "1.005" "1.068" "1.110" "0.933" "1.060" "1.057" "1.037" "424.9" "429.4" "443.0" "427.2" "453.7" "471.6" "396.4" "450.4" "449.2" "440.5" "" "" "" "" "" "" "" "" "" "" "398.2" "355.4" "411.2" "330.3" "386.7" "450.6" "362.2" "399.9" "449.2" "424.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1997849162023251854" "False" "High" "IsMasterProtein" "P63208" "S-phase kinase-associated protein 1 OS=Homo sapiens OX=9606 GN=SKP1 PE=1 SV=2" "0.000" "False" "9.385" "38" "4" "4" "4" "163" "18.6" "4.54" "8.20" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01466, Pf03931" "6500" "ENSG00000113558" "SKP1" "D3DQ97; D3DQ98; hsa:6500; P34991; P63208; Q8TAY2" "Cell cycle; TNF-alpha signaling pathway; TGF-beta signaling pathway; Breast cancer pathway; Small cell lung cancer; Notch signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of PLK1 Activity at G2/M Transition; Circadian Clock; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Cyclin D associated events in G1; Regulation of BACH1 activity; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Iron uptake and transport; Nuclear events stimulated by ALK signaling in cancer; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "39" "0" "1.098" "0.945" "0.934" "0.996" "0.941" "0.917" "0.991" "1.081" "0.995" "131.7" "144.6" "124.4" "123.0" "131.1" "123.9" "120.7" "130.5" "142.3" "131.0" "" "" "" "" "" "" "" "" "" "" "123.4" "119.7" "115.5" "95.1" "111.8" "118.4" "110.3" "115.8" "142.3" "126.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7160695848866474340" "False" "High" "IsMasterProtein" "Q96JG6" "Syndetin OS=Homo sapiens OX=9606 GN=VPS50 PE=1 SV=3" "0.000" "False" "9.384" "4" "4" "5" "4" "964" "111.1" "6.20" "13.29" "4" "transport" "other cytoplasmic organelle;other cell component" "other molecular function" "Pf10474, Pf10475" "55610" "ENSG00000004766" "VPS50" "B3KX22; D1MQ00; F5H5U7; hsa:55610; Q75N07; Q8WVK3; Q96JG6; Q9H5C6" "" "" "0" "0" "0.994" "0.993" "1.015" "0.995" "0.981" "0.969" "0.985" "0.983" "1.010" "339.2" "337.0" "336.7" "344.3" "337.6" "332.7" "328.5" "334.2" "333.5" "342.5" "" "" "" "" "" "" "" "" "" "" "317.8" "278.8" "312.6" "266.2" "287.7" "317.8" "300.2" "296.7" "333.5" "329.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5067244968494119358" "False" "High" "IsMasterProtein" "O75496" "Geminin OS=Homo sapiens OX=9606 GN=GMNN PE=1 SV=1" "0.000" "False" "9.359" "14" "3" "4" "3" "209" "23.6" "4.96" "13.47" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07412" "51053" "ENSG00000112312" "GMNN" "B3KMM8; hsa:51053; O75496; Q9H1Z1" "DNA replication; DYRK1A involvement regarding cell proliferation in brain development" "Assembly of the pre-replicative complex; Activation of the pre-replicative complex; Switching of origins to a post-replicative state" "5" "0" "1.039" "0.969" "0.963" "0.967" "0.956" "0.880" "0.946" "0.912" "0.975" "1041.5" "1082.3" "1009.3" "1003.0" "1006.9" "995.5" "916.8" "985.6" "949.9" "1015.0" "" "" "" "" "" "" "" "" "" "" "975.9" "895.6" "937.0" "775.3" "858.2" "951.2" "837.7" "875.1" "949.9" "977.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6366050407919946154" "False" "High" "IsMasterProtein" "Q96II8" "DISP complex protein LRCH3 OS=Homo sapiens OX=9606 GN=LRCH3 PE=1 SV=2" "0.000" "False" "9.350" "4" "4" "5" "3" "777" "86.0" "6.71" "15.33" "4" "cell organization and biogenesis" "cytosol;other cell component" "" "Pf00307, Pf13855" "84859" "ENSG00000186001" "LRCH3" "B4E0T7; hsa:84859; Q96FP9; Q96II8; Q9NT52" "" "" "0" "1" "0.924" "0.955" "0.895" "0.936" "1.018" "0.891" "0.900" "0.928" "0.957" "1078.1" "996.4" "1029.5" "965.0" "1009.2" "1097.0" "960.9" "970.3" "1000.1" "1031.9" "" "" "" "" "" "" "" "" "" "" "1010.2" "824.5" "955.7" "746.0" "860.2" "1048.1" "878.0" "861.5" "1000.1" "993.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3710113209643881705" "False" "High" "IsMasterProtein" "O75794" "Translation initiation factor eIF2 assembly protein OS=Homo sapiens OX=9606 GN=CDC123 PE=1 SV=1" "0.000" "False" "9.333" "11" "4" "7" "4" "336" "39.1" "4.81" "18.70" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other cell component" "" "Pf07065" "8872" "ENSG00000151465" "CDC123" "A8JZZ7; hsa:8872; O75794; Q14107; Q5T0L4; Q5T0L5; Q5T0L7; Q5T0L8; Q5T0L9" "" "" "0" "0" "0.986" "0.974" "1.093" "1.070" "1.077" "1.014" "1.082" "1.155" "1.027" "617.5" "608.9" "601.5" "675.1" "660.8" "665.3" "626.1" "668.1" "713.1" "634.4" "" "" "" "" "" "" "" "" "" "" "578.6" "503.9" "558.4" "521.9" "563.3" "635.6" "572.1" "593.2" "713.1" "610.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8893850793131937072" "False" "High" "IsMasterProtein" "O95749" "Geranylgeranyl pyrophosphate synthase OS=Homo sapiens OX=9606 GN=GGPS1 PE=1 SV=1" "0.000" "False" "9.329" "12" "4" "5" "4" "300" "34.8" "6.14" "4.17" "4" "other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00348" "9453" "ENSG00000152904" "GGPS1" "A8MVQ8; hsa:9453; O95749; Q5T2C8; Q6NW19" "Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis pathway in hepatocytes" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "451284985450217438" "False" "High" "IsMasterProtein" "Q9NVV4" "Poly(A) RNA polymerase, mitochondrial OS=Homo sapiens OX=9606 GN=MTPAP PE=1 SV=1" "0.000" "False" "9.324" "4" "3" "4" "3" "582" "66.1" "9.04" "15.27" "3" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf03828, Pf17797" "55149" "ENSG00000107951" "MTPAP" "D3DRX0; hsa:55149; Q659E3; Q6P7E5; Q9HA74; Q9NVV4" "" "" "0" "0" "1.003" "1.076" "0.907" "1.129" "1.184" "1.080" "1.146" "1.173" "1.138" "548.2" "549.6" "589.6" "497.0" "618.8" "649.0" "591.8" "628.2" "643.3" "623.9" "" "" "" "" "" "" "" "" "" "" "513.7" "454.8" "547.4" "384.2" "527.4" "620.0" "540.8" "557.8" "643.3" "600.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3683679323439236664" "False" "High" "IsMasterProtein" "Q6IPR3" "tRNA wybutosine-synthesizing protein 3 homolog OS=Homo sapiens OX=9606 GN=TYW3 PE=1 SV=2" "0.000" "False" "9.323" "11" "3" "5" "3" "259" "29.8" "7.68" "13.39" "3" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf02676" "127253" "ENSG00000162623" "TYW3" "B4DSP9; E9PGR7; hsa:127253; Q5HYJ0; Q6IPR3; Q8N7L1" "" "Synthesis of wybutosine at G37 of tRNA(Phe)" "1" "0" "0.935" "0.930" "0.965" "0.986" "1.012" "1.032" "0.880" "0.878" "0.969" "208.5" "194.9" "193.9" "201.1" "205.6" "210.9" "215.1" "183.5" "183.1" "202.1" "" "" "" "" "" "" "" "" "" "" "195.3" "161.3" "180.0" "155.5" "175.2" "201.5" "196.6" "162.9" "183.1" "194.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9200930033631648957" "False" "High" "IsMasterProtein" "Q06413" "Myocyte-specific enhancer factor 2C OS=Homo sapiens OX=9606 GN=MEF2C PE=1 SV=1" "0.000" "False" "9.318" "7" "3" "4" "1" "473" "51.2" "8.03" "8.75" "3" "cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4208" "ENSG00000081189" "MEF2C" "C9JMZ0; D7F7N5; F8W7V7; hsa:4208; Q06413" "Energy metabolism; Heart development; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; B cell receptor signaling pathway; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Prion disease pathway; Rett syndrome; EGF/EGFR signaling pathway; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; GDNF signaling; 2q37 copy number variation syndrome; Neurogenesis regulation in the olfactory epithelium; Sudden infant death syndrome (SIDS) susceptibility pathways" "ERK/MAPK targets; Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Myogenesis; Cardiogenesis; MECP2 regulates transcription factors" "30" "0" "1.015" "1.008" "1.079" "1.149" "1.083" "1.106" "0.989" "0.938" "1.034" "199.4" "202.4" "201.1" "215.3" "229.3" "216.0" "220.6" "197.2" "187.0" "206.2" "" "" "" "" "" "" "" "" "" "" "186.9" "167.5" "186.7" "166.4" "195.4" "206.3" "201.6" "175.1" "187.0" "198.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3208600518816650541" "False" "High" "IsMasterProtein" "Q96IU4" "Putative protein-lysine deacylase ABHD14B OS=Homo sapiens OX=9606 GN=ABHD14B PE=1 SV=1" "0.000" "False" "9.314" "13" "3" "4" "3" "210" "22.3" "6.40" "10.29" "3" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12697" "84836" "ENSG00000114779" "ABHD14B" "hsa:84836; Q86VK8; Q8N8W5; Q96IU4" "" "Cytosolic sulfonation of small molecules" "1" "0" "0.957" "1.094" "0.829" "0.937" "0.980" "0.901" "0.992" "1.010" "0.996" "643.3" "615.5" "704.0" "533.5" "603.0" "630.5" "579.8" "637.9" "649.5" "640.6" "" "" "" "" "" "" "" "" "" "" "602.8" "509.3" "653.6" "412.5" "514.0" "602.4" "529.8" "566.4" "649.5" "616.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2776993726351284183" "False" "High" "IsMasterProtein" "Q9BVJ6" "U3 small nucleolar RNA-associated protein 14 homolog A OS=Homo sapiens OX=9606 GN=UTP14A PE=1 SV=1" "0.000" "False" "9.309" "5" "3" "4" "3" "771" "87.9" "7.87" "13.29" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf04615" "10813" "ENSG00000156697" "UTP14A" "A8K7A3; A8MVQ1; B4DQ08; E9PEL7; hsa:10813; Q5JYF1; Q9BVJ6" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.243" "1.172" "1.514" "1.408" "1.252" "1.629" "1.504" "1.592" "1.359" "67.0" "83.3" "78.6" "101.5" "94.3" "83.9" "109.2" "100.8" "106.7" "91.1" "" "" "" "" "" "" "" "" "" "" "62.8" "69.0" "72.9" "78.4" "80.4" "80.2" "99.8" "89.5" "106.7" "87.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7745810489150015985" "False" "High" "IsMasterProtein" "O95292" "Vesicle-associated membrane protein-associated protein B/C OS=Homo sapiens OX=9606 GN=VAPB PE=1 SV=3" "0.000" "False" "9.300" "11" "3" "4" "2" "243" "27.2" "7.30" "10.23" "3" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00635" "9217" "ENSG00000124164" "VAPB" "A2A2F2; hsa:9217; O95292; O95293; Q9P0H0" "Ciliary landscape" "RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; Sphingolipid de novo biosynthesis; RAC2 GTPase cycle; RHOD GTPase cycle" "7" "1" "1.038" "1.047" "1.002" "1.079" "1.096" "1.118" "1.061" "1.200" "1.136" "274.8" "285.1" "287.8" "275.3" "296.5" "301.2" "307.3" "291.6" "329.7" "312.0" "" "" "" "" "" "" "" "" "" "" "257.5" "235.9" "267.2" "212.8" "252.8" "287.8" "280.8" "259.0" "329.7" "300.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4412220755654312839" "False" "High" "IsMasterProtein" "Q15652" "Probable JmjC domain-containing histone demethylation protein 2C OS=Homo sapiens OX=9606 GN=JMJD1C PE=1 SV=2" "0.000" "False" "9.278" "1" "4" "4" "3" "2540" "284.3" "7.87" "11.78" "4" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "221037" "ENSG00000171988" "JMJD1C" "A0T124; hsa:221037; Q15652; Q5SQZ8; Q5SQZ9; Q5SR00; Q7Z3E7; Q8N3U0; Q96KB9; Q9P2G7" "Pathways affected in adenoid cystic carcinoma" "Factors involved in megakaryocyte development and platelet production" "2" "0" "1.222" "1.067" "1.332" "1.188" "1.223" "1.286" "1.076" "1.202" "1.185" "118.1" "144.2" "125.9" "157.3" "140.3" "144.3" "151.8" "127.0" "141.9" "139.8" "" "" "" "" "" "" "" "" "" "" "110.6" "119.3" "116.9" "121.6" "119.6" "137.9" "138.7" "112.7" "141.9" "134.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4746768512254432328" "False" "High" "IsMasterProtein" "Q9Y4X5" "E3 ubiquitin-protein ligase ARIH1 OS=Homo sapiens OX=9606 GN=ARIH1 PE=1 SV=2" "0.000" "False" "9.275" "6" "3" "3" "3" "557" "64.1" "5.08" "12.11" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097, Pf01485, Pf19422, Pf21235" "25820" "ENSG00000166233" "ARIH1" "B2R6U3; hsa:25820; O76026; Q9H3T6; Q9UEN0; Q9UP39; Q9Y4X5" "" "PKR-mediated signaling; ISG15 antiviral mechanism; RSV-host interactions" "3" "0" "1.002" "0.971" "1.000" "0.921" "0.992" "1.038" "0.944" "0.964" "0.964" "593.9" "595.0" "577.0" "594.2" "546.8" "589.0" "616.4" "560.5" "572.6" "572.3" "" "" "" "" "" "" "" "" "" "" "556.5" "492.3" "535.7" "459.3" "466.1" "562.8" "563.2" "497.7" "572.6" "551.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5788074156748143009" "False" "High" "IsMasterProtein" "Q96IJ6" "Mannose-1-phosphate guanyltransferase alpha OS=Homo sapiens OX=9606 GN=GMPPA PE=1 SV=1" "0.000" "False" "9.270" "11" "4" "4" "4" "420" "46.3" "7.21" "8.18" "4" "other metabolic processes" "other cell component" "other molecular function" "Pf00132, Pf00483" "29926" "ENSG00000144591" "GMPPA" "A6NJ74; A8K3Q6; B3KMT4; hsa:29926; Q53GI0; Q96IJ6; Q9NWC3; Q9Y5P5" "N-glycan biosynthesis" "Synthesis of GDP-mannose" "2" "0" "0.980" "0.988" "1.099" "1.085" "1.011" "1.059" "0.979" "1.203" "1.030" "261.5" "256.4" "258.3" "287.3" "283.7" "264.3" "277.0" "255.9" "314.5" "269.4" "" "" "" "" "" "" "" "" "" "" "245.0" "212.2" "239.8" "222.1" "241.8" "252.5" "253.1" "227.2" "314.5" "259.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8571260626068012330" "False" "High" "IsMasterProtein" "Q9NXK8" "F-box/LRR-repeat protein 12 OS=Homo sapiens OX=9606 GN=FBXL12 PE=1 SV=1" "0.000" "False" "9.265" "10" "3" "3" "3" "326" "37.0" "8.79" "9.52" "3" "protein metabolism;other metabolic processes" "cytosol;other cell component" "" "Pf12937" "54850" "ENSG00000127452" "FBXL12" "B3KSJ8; hsa:54850; Q9H5K4; Q9NXK8" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "0.885" "1.016" "1.112" "1.121" "1.059" "1.077" "0.962" "1.087" "1.009" "162.9" "144.2" "165.5" "181.2" "182.6" "172.5" "175.5" "156.8" "177.2" "164.3" "" "" "" "" "" "" "" "" "" "" "152.7" "119.3" "153.6" "140.1" "155.7" "164.8" "160.4" "139.2" "177.2" "158.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6462118287367883221" "False" "High" "IsMasterProtein" "Q9Y296" "Trafficking protein particle complex subunit 4 OS=Homo sapiens OX=9606 GN=TRAPPC4 PE=1 SV=1" "0.000" "False" "9.257" "11" "3" "5" "3" "219" "24.3" "6.21" "15.91" "3" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04099" "51399" "ENSG00000196655; ENSG00000280495" "TRAPPC4" "A8K3A5; B4DME1; hsa:51399; Q9Y296" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport; Syndecan interactions" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1103469562335054989" "False" "High" "IsMasterProtein" "Q8WUF8" "Cotranscriptional regulator ARB2A OS=Homo sapiens OX=9606 GN=ARB2A PE=1 SV=1" "0.000" "False" "9.256" "8" "3" "3" "3" "416" "47.9" "6.09" "8.96" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus" "" "Pf09757" "83989" "ENSG00000113391" "ARB2A" "B2R7C6; B4DJ14; B4DLG5; hsa:83989; Q8WUF8; Q9H0U8" "" "" "0" "0" "0.970" "0.960" "1.071" "1.051" "0.976" "0.924" "0.963" "0.924" "1.000" "268.6" "260.6" "257.9" "287.7" "282.3" "262.2" "248.2" "258.6" "248.3" "268.5" "" "" "" "" "" "" "" "" "" "" "251.7" "215.6" "239.5" "222.4" "240.6" "250.5" "226.8" "229.6" "248.3" "258.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-126462466589207022" "False" "High" "IsMasterProtein" "P18440" "Arylamine N-acetyltransferase 1 OS=Homo sapiens OX=9606 GN=NAT1 PE=1 SV=2" "0.000" "False" "9.213" "10" "3" "3" "3" "290" "33.9" "6.54" "7.76" "3" "other metabolic processes" "cytosol" "other molecular function" "Pf00797" "9" "ENSG00000171428" "NAT1" "A8K4E7; hsa:9; O15159; O15300; P18440; Q546N1; Q96TE9" "Omega-6-fatty acids in senescence; Arylamine metabolism; Metapathway biotransformation Phase I and II" "Paracetamol ADME; Acetylation" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8892747589052197154" "False" "High" "IsMasterProtein" "Q5W0B1" "ORC ubiquitin ligase 1 OS=Homo sapiens OX=9606 GN=OBI1 PE=1 SV=1" "0.000" "False" "9.203" "5" "3" "3" "3" "726" "81.1" "5.72" "9.91" "3" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf13923" "79596" "ENSG00000152193" "OBI1" "B2RN99; hsa:79596; Q5W0B1; Q8TBY2; Q9H0T2; Q9H8M0" "" "" "0" "0" "1.081" "1.022" "1.091" "0.932" "1.016" "0.986" "0.942" "1.019" "1.011" "160.2" "173.2" "163.8" "174.8" "149.4" "162.8" "158.0" "151.0" "163.2" "162.0" "" "" "" "" "" "" "" "" "" "" "150.1" "143.3" "152.1" "135.1" "127.3" "155.5" "144.4" "134.1" "163.2" "156.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8254999691274013684" "False" "High" "IsMasterProtein" "Q9HAV0" "Guanine nucleotide-binding protein subunit beta-4 OS=Homo sapiens OX=9606 GN=GNB4 PE=1 SV=3" "0.000" "False" "9.199" "8" "3" "4" "3" "340" "37.5" "6.00" "12.99" "3" "signal transduction" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00400" "59345" "ENSG00000114450" "GNB4" "B3KMH5; D3DNR8; hsa:59345; Q9HAV0" "Myometrial relaxation and contraction pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells" "G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; G alpha (12/13) signalling events; G alpha (q) signalling events; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "34" "0" "0.858" "1.001" "1.096" "0.971" "0.905" "0.991" "0.924" "0.865" "0.853" "165.6" "142.0" "165.8" "181.4" "160.7" "149.9" "164.1" "153.0" "143.2" "141.3" "" "" "" "" "" "" "" "" "" "" "155.1" "117.5" "153.9" "140.3" "137.0" "143.2" "149.9" "135.8" "143.2" "136.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3798154804985713391" "False" "High" "IsMasterProtein" "P41229" "Lysine-specific demethylase 5C OS=Homo sapiens OX=9606 GN=KDM5C PE=1 SV=2" "0.000" "False" "9.198" "2" "3" "3" "3" "1560" "175.6" "5.58" "10.65" "3" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00628, Pf01388, Pf02373, Pf02375, Pf02928, Pf08429, Pf21323" "8242" "ENSG00000126012" "KDM5C" "B0QZ44; B4E3I2; F5H3T1; hsa:8242; P41229; Q5JUX3; Q5JUX4; Q5JUX5; Q7Z5S5" "Clear cell renal cell carcinoma pathways" "HDMs demethylate histones" "2" "0" "0.959" "1.021" "1.039" "0.972" "1.008" "1.058" "0.952" "0.962" "1.012" "448.5" "429.9" "458.0" "466.0" "436.1" "452.0" "474.5" "426.9" "431.2" "454.1" "" "" "" "" "" "" "" "" "" "" "420.2" "355.7" "425.2" "360.2" "371.7" "431.9" "433.6" "379.1" "431.2" "437.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7361850666082059512" "False" "High" "IsMasterProtein" "P54252" "Ataxin-3 OS=Homo sapiens OX=9606 GN=ATXN3 PE=1 SV=5" "0.000" "False" "9.182" "12" "4" "4" "4" "361" "41.2" "4.78" "8.30" "4" "cell-cell signaling;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02099, Pf02809, Pf16619" "4287" "ENSG00000066427" "ATXN3" "A7LFZ5; D6RDL9; E9PB63; hsa:4287; O15284; O15285; O15286; P54252; Q8N189; Q96TC3; Q96TC4; Q9H3N0" "HDAC6 interactions in the central nervous system" "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Josephin domain DUBs" "3" "0" "0.876" "0.886" "0.989" "0.950" "0.834" "0.920" "0.887" "0.841" "0.901" "246.1" "215.6" "218.1" "243.4" "233.9" "205.2" "226.6" "218.2" "207.0" "221.6" "" "" "" "" "" "" "" "" "" "" "230.6" "178.4" "202.5" "188.1" "199.4" "196.0" "207.0" "193.8" "207.0" "213.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-651184813655133351" "False" "High" "IsMasterProtein" "P13807" "Glycogen [starch] synthase, muscle OS=Homo sapiens OX=9606 GN=GYS1 PE=1 SV=2" "0.000" "False" "9.181" "4" "3" "4" "3" "737" "83.7" "6.18" "13.13" "3" "other metabolic processes;developmental processes" "cytosol;other cell component" "other molecular function" "Pf05693" "2997" "ENSG00000104812" "GYS1" "hsa:2997; P13807; Q9BTT9" "AMP-activated protein kinase signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Insulin signaling; Glycogen synthesis and degradation; Disorders of galactose metabolism ; 2q37 copy number variation syndrome" "Glycogen synthesis; Myoclonic epilepsy of Lafora; Glycogen storage disease type XV (GYG1); Glycogen storage disease type 0 (muscle GYS1)" "12" "0" "1.044" "1.103" "1.138" "1.083" "0.980" "1.072" "1.147" "1.100" "1.076" "326.0" "340.2" "359.7" "371.0" "353.1" "319.4" "349.4" "374.0" "358.5" "350.8" "" "" "" "" "" "" "" "" "" "" "305.5" "281.5" "334.0" "286.8" "301.0" "305.2" "319.3" "332.0" "358.5" "337.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2735556346422021928" "False" "High" "IsMasterProtein" "P53384" "Cytosolic Fe-S cluster assembly factor NUBP1 OS=Homo sapiens OX=9606 GN=NUBP1 PE=1 SV=2" "0.000" "False" "9.178" "11" "3" "4" "3" "320" "34.5" "5.33" "12.27" "3" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10609" "4682" "ENSG00000103274" "NUBP1" "hsa:4682; P53384; Q32M30; Q498A9; Q53FS7" "Iron-sulfur cluster biogenesis" "Cytosolic iron-sulfur cluster assembly" "2" "0" "1.048" "0.998" "0.988" "1.064" "0.966" "0.952" "0.914" "0.920" "1.008" "270.4" "283.5" "269.9" "267.1" "287.7" "261.3" "257.4" "247.1" "248.7" "272.5" "" "" "" "" "" "" "" "" "" "" "253.3" "234.6" "250.5" "206.5" "245.3" "249.6" "235.2" "219.4" "248.7" "262.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8542796064985296864" "False" "High" "IsMasterProtein" "Q969Y2" "tRNA modification GTPase GTPBP3, mitochondrial OS=Homo sapiens OX=9606 GN=GTPBP3 PE=1 SV=2" "0.000" "False" "9.164" "6" "3" "3" "3" "492" "52.0" "6.48" "12.12" "3" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf01926, Pf10396, Pf12631" "84705" "ENSG00000130299" "GTPBP3" "A6NFH1; A6NIG5; A6NKR4; A8K7B4; B7Z4V8; hsa:84705; Q8TCY6; Q8WUW9; Q969G4; Q969Y2; Q9BX61" "" "tRNA modification in the mitochondrion" "1" "0" "1.021" "0.958" "0.984" "0.983" "1.005" "0.985" "1.013" "1.020" "0.958" "194.9" "199.0" "186.6" "191.7" "191.6" "196.0" "192.0" "197.5" "198.8" "186.8" "" "" "" "" "" "" "" "" "" "" "182.6" "164.7" "173.3" "148.2" "163.3" "187.2" "175.5" "175.3" "198.8" "179.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5441876211868438473" "False" "High" "IsMasterProtein" "Q92585" "Mastermind-like protein 1 OS=Homo sapiens OX=9606 GN=MAML1 PE=1 SV=3" "0.000" "False" "9.161" "4" "3" "3" "3" "1016" "108.0" "8.28" "7.43" "3" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09596, Pf20801, Pf20802" "9794" "ENSG00000161021; ENSG00000283780" "MAML1" "hsa:9794; Q92585; Q9NZ12" "Notch signaling; Canonical and non-canonical Notch signaling; Head and neck squamous cell carcinoma; Notch signaling pathway" "NOTCH3 Intracellular Domain Regulates Transcription; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH2 intracellular domain regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "15" "0" "1.109" "0.972" "1.090" "1.009" "0.937" "0.925" "0.925" "1.011" "1.025" "247.5" "274.4" "240.5" "269.7" "249.7" "231.8" "229.0" "228.8" "250.3" "253.6" "" "" "" "" "" "" "" "" "" "" "231.9" "227.0" "223.3" "208.5" "212.8" "221.5" "209.2" "203.2" "250.3" "244.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5929165091375925329" "False" "High" "IsMasterProtein" "Q15545" "Transcription initiation factor TFIID subunit 7 OS=Homo sapiens OX=9606 GN=TAF7 PE=1 SV=1" "0.000" "False" "9.148" "8" "3" "3" "3" "349" "40.2" "5.20" "10.17" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04658" "6879" "ENSG00000178913" "TAF7" "B2RBV9; hsa:6879; Q13036; Q15545" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; Regulation of TP53 Activity through Phosphorylation; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "10" "0" "0.955" "0.911" "0.928" "1.007" "1.009" "0.876" "0.980" "0.997" "0.996" "368.3" "351.5" "335.4" "341.7" "370.9" "371.7" "322.7" "360.8" "367.1" "366.9" "" "" "" "" "" "" "" "" "" "" "345.1" "290.9" "311.4" "264.1" "316.1" "355.1" "294.8" "320.4" "367.1" "353.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7727085808198553563" "False" "High" "IsMasterProtein" "P30291" "Wee1-like protein kinase OS=Homo sapiens OX=9606 GN=WEE1 PE=1 SV=2" "0.000" "False" "9.148" "6" "4" "4" "4" "646" "71.6" "6.77" "9.44" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "7465" "ENSG00000166483" "WEE1" "B3KVE1; D3DQV0; hsa:7465; P30291" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control" "Factors involved in megakaryocyte development and platelet production; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Cyclin A/B1/B2 associated events during G2/M transition; Polo-like kinase mediated events; G2/M DNA replication checkpoint; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5564485370032939878" "False" "High" "IsMasterProtein" "Q9UBV8" "Peflin OS=Homo sapiens OX=9606 GN=PEF1 PE=1 SV=1" "0.000" "False" "9.141" "11" "3" "4" "3" "284" "30.4" "6.54" "12.53" "3" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf13405, Pf13499" "553115" "ENSG00000162517" "PEF1" "hsa:553115; Q9UBV8" "" "" "0" "0" "1.090" "1.018" "1.034" "1.119" "1.151" "1.057" "1.079" "1.154" "1.113" "448.1" "488.2" "456.2" "463.4" "501.2" "515.7" "473.7" "483.6" "516.8" "498.7" "" "" "" "" "" "" "" "" "" "" "419.8" "404.0" "423.5" "358.2" "427.2" "492.7" "432.9" "429.4" "516.8" "480.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "583939558635172856" "False" "High" "IsMasterProtein" "Q9Y4P1" "Cysteine protease ATG4B OS=Homo sapiens OX=9606 GN=ATG4B PE=1 SV=2" "0.000" "False" "9.136" "8" "3" "3" "3" "393" "44.3" "5.07" "9.55" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03416, Pf20166" "23192" "ENSG00000168397" "ATG4B" "B7WNK2; hsa:23192; Q53NU4; Q6ZUV8; Q8WYM9; Q96K07; Q96K96; Q96SZ1; Q9Y2F2; Q9Y4P1" "2q37 copy number variation syndrome" "Macroautophagy" "2" "0" "0.847" "0.997" "0.902" "0.942" "0.954" "0.942" "0.902" "0.985" "0.961" "776.6" "657.5" "774.3" "700.8" "731.7" "740.9" "731.5" "700.6" "765.3" "746.0" "" "" "" "" "" "" "" "" "" "" "727.7" "544.1" "718.8" "541.8" "623.7" "707.9" "668.4" "622.1" "765.3" "718.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-331948696601358906" "False" "High" "IsMasterProtein" "Q969T7" "7-methylguanosine phosphate-specific 5'-nucleotidase OS=Homo sapiens OX=9606 GN=NT5C3B PE=1 SV=4" "0.000" "False" "9.119" "9" "3" "3" "3" "300" "34.4" "6.38" "8.07" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf05822" "115024" "ENSG00000141698" "NT5C3B" "A8MWB9; C9JKC4; hsa:115024; Q7L3B7; Q969T7" "" "mRNA decay by 3' to 5' exoribonuclease" "1" "0" "0.991" "1.078" "1.028" "1.151" "1.120" "1.023" "1.040" "1.183" "1.116" "273.9" "271.4" "295.3" "281.5" "315.2" "306.7" "280.2" "284.7" "324.1" "305.7" "" "" "" "" "" "" "" "" "" "" "256.6" "224.6" "274.2" "217.6" "268.6" "293.0" "256.1" "252.8" "324.1" "294.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4102844417532121967" "False" "High" "IsMasterProtein" "Q15560" "Transcription elongation factor A protein 2 OS=Homo sapiens OX=9606 GN=TCEA2 PE=1 SV=1" "0.000" "False" "9.105" "11" "3" "3" "1" "299" "33.6" "9.13" "9.84" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf07500, Pf08711" "6919" "ENSG00000171703" "TCEA2" "B3KNM1; Q15560; Q8TD37; Q8TD38" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2659505507426523226" "False" "High" "IsMasterProtein" "P0CAP2" "DNA-directed RNA polymerase II subunit GRINL1A OS=Homo sapiens OX=9606 GN=POLR2M PE=1 SV=1" "0.000" "False" "9.102" "10" "3" "3" "3" "368" "41.7" "6.39" "8.41" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15328" "81488" "ENSG00000255529" "POLR2M" "hsa:81488; P0CAP2; Q6EER8; Q6EES2; Q6EEV3; Q6EF00; Q6EF01; Q6EF02; Q6EF46; Q6EFN8; Q6EM48; Q6K046; Q6K050; Q6K051; Q6ZQZ3; Q8NC58; Q8NCF3; Q96DI5; Q96JB7; Q96NF5; Q9Y3V6" "" "" "0" "0" "0.937" "0.916" "0.888" "1.018" "0.942" "0.959" "0.935" "1.100" "0.896" "103.7" "97.1" "95.0" "92.1" "105.6" "97.7" "99.4" "97.0" "114.0" "92.9" "" "" "" "" "" "" "" "" "" "" "97.1" "80.4" "88.2" "71.2" "90.0" "93.3" "90.8" "86.1" "114.0" "89.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6915758716299824080" "False" "High" "IsMasterProtein" "Q06787" "Fragile X messenger ribonucleoprotein 1 OS=Homo sapiens OX=9606 GN=FMR1 PE=1 SV=1" "0.000" "False" "9.098" "7" "4" "5" "2" "632" "71.1" "7.42" "15.14" "4" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16098, Pf17904, Pf18336" "2332" "ENSG00000102081" "FMR1" "A6NNH4; D3DWT0; D3DWT1; D3DWT2; G8JL90; hsa:2332; Q06787; Q16578; Q5PQZ6; Q99054" "Ovarian infertility; Serotonin and anxiety; Prader-Willi and Angelman syndrome; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; 15q11.2 copy number variation syndrome; Primary ovarian insufficiency" "" "7" "0" "1.067" "0.985" "1.199" "1.166" "1.039" "1.152" "1.103" "1.107" "1.093" "239.3" "255.4" "235.8" "286.9" "279.1" "248.6" "275.7" "263.9" "264.9" "261.7" "" "" "" "" "" "" "" "" "" "" "224.2" "211.3" "218.9" "221.7" "237.9" "237.5" "251.9" "234.3" "264.9" "251.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8682459872602538883" "False" "High" "IsMasterProtein" "Q8N108" "Mesoderm induction early response protein 1 OS=Homo sapiens OX=9606 GN=MIER1 PE=1 SV=2" "0.000" "False" "9.093" "8" "4" "4" "4" "512" "57.9" "4.42" "12.42" "4" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf19426" "57708" "ENSG00000198160" "MIER1" "C9JFD4; hsa:57708; Q08AE0; Q32NC4; Q5T104; Q5TAD1; Q5TAD2; Q5TAD4; Q5TAD5; Q6AHY8; Q86TB4; Q8N108; Q8N156; Q8N161; Q8NC37; Q8NES4; Q8NES5; Q8NES6; Q8WWG2; Q9HCG2" "" "" "0" "0" "1.082" "1.053" "0.973" "1.065" "1.066" "1.081" "1.057" "1.056" "1.075" "374.2" "405.1" "394.1" "364.2" "398.6" "398.9" "404.5" "395.7" "395.1" "402.4" "" "" "" "" "" "" "" "" "" "" "350.7" "335.2" "365.9" "281.6" "339.7" "381.1" "369.6" "351.3" "395.1" "387.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3659552786150411994" "False" "High" "IsMasterProtein" "O75127" "Pentatricopeptide repeat-containing protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=PTCD1 PE=1 SV=2" "0.000" "False" "9.089" "4" "3" "3" "3" "700" "78.8" "8.59" "8.85" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity" "Pf01535" "26024" "ENSG00000106246" "PTCD1" "hsa:26024; O75127; Q3ZB78; Q66K60; Q9UDV2" "" "" "0" "0" "1.034" "1.020" "1.152" "1.044" "1.073" "1.147" "1.044" "1.108" "1.079" "598.6" "619.1" "610.3" "689.6" "625.2" "642.4" "686.7" "624.8" "663.0" "645.8" "" "" "" "" "" "" "" "" "" "" "560.9" "512.3" "566.6" "533.1" "532.9" "613.8" "627.5" "554.7" "663.0" "621.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1490025525500914879" "False" "High" "IsMasterProtein" "O43929" "Origin recognition complex subunit 4 OS=Homo sapiens OX=9606 GN=ORC4 PE=1 SV=2" "0.000" "False" "9.088" "7" "3" "3" "3" "436" "50.3" "8.00" "8.70" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13191, Pf14629" "5000" "ENSG00000115947" "ORC4" "B7Z3D0; B7Z5F1; D3DP86; F5H069; hsa:5000; O43929; Q96C42" "Cell cycle; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication; CDC6 association with the ORC:origin complex" "10" "0" "0.979" "0.961" "1.050" "1.066" "1.001" "1.029" "0.896" "0.977" "1.036" "200.8" "196.5" "193.0" "210.7" "214.0" "200.9" "206.6" "179.9" "196.1" "208.0" "" "" "" "" "" "" "" "" "" "" "188.1" "162.6" "179.2" "162.9" "182.4" "192.0" "188.8" "159.7" "196.1" "200.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1816223727671685711" "False" "High" "IsMasterProtein" "A1L020" "RNA-binding protein MEX3A OS=Homo sapiens OX=9606 GN=MEX3A PE=1 SV=1" "0.000" "False" "9.083" "9" "3" "3" "2" "520" "54.1" "7.27" "10.78" "3" "" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf13920" "92312" "ENSG00000254726" "MEX3A" "A1L020; hsa:92312" "" "" "0" "0" "1.112" "1.185" "1.272" "1.335" "1.362" "1.333" "1.172" "1.382" "1.386" "28.0" "31.1" "33.2" "35.6" "37.4" "38.2" "37.3" "32.8" "38.7" "38.8" "" "" "" "" "" "" "" "" "" "" "26.2" "25.8" "30.8" "27.5" "31.9" "36.5" "34.1" "29.1" "38.7" "37.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2608297445267441955" "False" "High" "IsMasterProtein" "Q96QR8" "Transcriptional regulator protein Pur-beta OS=Homo sapiens OX=9606 GN=PURB PE=1 SV=3" "0.000" "False" "9.081" "10" "3" "3" "3" "312" "33.2" "5.43" "9.11" "3" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf04845" "5814" "ENSG00000146676" "PURB" "A4D2L7; hsa:5814; Q96QR8" "" "" "0" "0" "1.002" "0.969" "0.993" "1.025" "0.983" "1.011" "0.990" "0.959" "1.043" "588.8" "590.2" "570.5" "584.7" "603.5" "578.6" "595.4" "582.8" "564.5" "614.4" "" "" "" "" "" "" "" "" "" "" "551.7" "488.4" "529.7" "452.0" "514.4" "552.8" "544.0" "517.5" "564.5" "591.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3564822305630524625" "False" "High" "IsMasterProtein" "Q96M27" "Protein PRRC1 OS=Homo sapiens OX=9606 GN=PRRC1 PE=1 SV=1" "0.000" "False" "9.073" "8" "4" "5" "4" "445" "46.7" "5.83" "13.48" "4" "" "ER/Golgi;other cell component" "other molecular function" "Pf01931" "133619" "ENSG00000164244" "PRRC1" "hsa:133619; Q69YM8; Q7L2U7; Q86Y42; Q8IVJ4; Q8IVL4; Q8NEZ7; Q96AJ3; Q96M27" "" "" "0" "0" "0.961" "0.956" "0.981" "1.006" "1.026" "0.947" "0.989" "0.907" "1.034" "817.0" "785.0" "780.8" "801.3" "821.6" "838.3" "773.9" "807.6" "741.4" "844.4" "" "" "" "" "" "" "" "" "" "" "765.5" "649.6" "724.9" "619.5" "700.3" "800.9" "707.1" "717.1" "741.4" "813.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6992356892802965689" "False" "High" "IsMasterProtein" "Q6UVJ0" "Spindle assembly abnormal protein 6 homolog OS=Homo sapiens OX=9606 GN=SASS6 PE=1 SV=1" "0.000" "False" "9.071" "4" "3" "4" "3" "657" "74.4" "7.55" "13.14" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf16531, Pf18594" "163786" "ENSG00000156876" "SASS6" "D3DT55; hsa:163786; Q6UVJ0; Q8N3K0" "Genes related to primary cilium development (based on CRISPR)" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4546155412470536460" "False" "High" "IsMasterProtein" "Q9NQS7" "Inner centromere protein OS=Homo sapiens OX=9606 GN=INCENP PE=1 SV=3" "0.000" "False" "9.069" "4" "3" "3" "3" "918" "105.4" "9.44" "10.08" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03941, Pf12178" "3619" "ENSG00000149503" "INCENP" "A8MQD2; hsa:3619; Q5Y192; Q9NQS7" "" "SUMOylation of DNA replication proteins; RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "1.177" "1.084" "1.407" "1.357" "1.333" "2.325" "2.266" "2.147" "1.562" "155.9" "183.5" "169.1" "219.4" "211.7" "207.8" "362.6" "353.4" "334.8" "243.5" "" "" "" "" "" "" "" "" "" "" "146.1" "151.9" "157.0" "169.6" "180.4" "198.5" "331.3" "313.8" "334.8" "234.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6548420804533655280" "False" "High" "IsMasterProtein" "O43353" "Receptor-interacting serine/threonine-protein kinase 2 OS=Homo sapiens OX=9606 GN=RIPK2 PE=1 SV=2" "0.000" "False" "9.064" "6" "3" "3" "3" "540" "61.2" "7.09" "7.52" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00619, Pf07714" "8767" "ENSG00000104312" "RIPK2" "B7Z748; hsa:8767; O43353; Q6UWF0" "Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; T-cell receptor signaling pathway" "Downstream TCR signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; p75NTR recruits signalling complexes; TAK1-dependent IKK and NF-kappa-B activation ; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases" "13" "0" "0.977" "0.910" "0.889" "0.888" "0.890" "1.026" "0.838" "0.967" "0.962" "255.4" "249.5" "232.4" "226.9" "226.8" "227.3" "262.0" "214.1" "246.8" "245.7" "" "" "" "" "" "" "" "" "" "" "239.3" "206.4" "215.7" "175.4" "193.4" "217.2" "239.4" "190.1" "246.8" "236.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6971851119340033318" "False" "High" "IsMasterProtein" "Q712K3" "Ubiquitin-conjugating enzyme E2 R2 OS=Homo sapiens OX=9606 GN=UBE2R2 PE=1 SV=1" "0.000" "False" "9.054" "13" "3" "3" "2" "238" "27.1" "4.42" "9.34" "3" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00179" "54926" "ENSG00000107341" "UBE2R2" "D3DRL5; hsa:54926; Q712K3; Q9NX64" "" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "2" "0" "1.114" "1.005" "1.136" "1.098" "1.049" "1.067" "1.058" "1.064" "0.984" "279.8" "311.5" "281.2" "317.7" "307.1" "293.6" "298.4" "295.9" "297.8" "275.4" "" "" "" "" "" "" "" "" "" "" "262.1" "257.8" "261.0" "245.6" "261.7" "280.5" "272.7" "262.8" "297.8" "265.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3819481250379265452" "False" "High" "IsMasterProtein" "Q5JWF2" "Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas OS=Homo sapiens OX=9606 GN=GNAS PE=1 SV=2" "0.000" "False" "9.048" "4" "4" "5" "3" "1037" "111.0" "5.03" "15.11" "4" "cell adhesion;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00503" "2778" "ENSG00000087460" "GNAS" "A2A2S3; E1P5G3; O75684; O75685; Q5JW67; Q5JWF1; Q5JWF2; Q9NY42" "Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; G protein signaling pathways; Thermogenesis; Hippo signaling regulation pathways; Purinergic signaling; GPR143 in melanocytes and retinal pigment epithelium cells; Vasopressin-regulated water reabsorption; Prostaglandin and leukotriene metabolism in senescence ; Primary ovarian insufficiency; Prostaglandin and leukotriene metabolism in senescence ; Calcium regulation in cardiac cells; Estrogen signaling pathway; Serotonin receptor 4/6/7 and NR3C signaling" "G alpha (i) signalling events; G alpha (z) signalling events; G alpha (s) signalling events; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Prostacyclin signalling through prostacyclin receptor; Glucagon-type ligand receptors; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation in glucagon signalling; Hedgehog 'off' state" "29" "0" "0.951" "1.123" "1.076" "1.122" "1.028" "1.053" "1.005" "0.938" "1.039" "351.9" "334.7" "395.1" "378.6" "395.0" "361.9" "370.5" "353.6" "330.1" "365.7" "" "" "" "" "" "" "" "" "" "" "329.7" "276.9" "366.8" "292.7" "336.7" "345.7" "338.5" "313.9" "330.1" "352.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2025748717046247647" "False" "High" "IsMasterProtein" "Q8IV63" "Serine/threonine-protein kinase VRK3 OS=Homo sapiens OX=9606 GN=VRK3 PE=1 SV=2" "0.000" "False" "9.044" "8" "3" "3" "3" "474" "52.8" "9.04" "10.52" "3" "signal transduction;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf13240" "51231" "ENSG00000105053" "VRK3" "A6NEG5; A8KA53; hsa:51231; Q502Y2; Q8IV63; Q9P2V8" "" "ERKs are inactivated" "1" "0" "1.092" "1.174" "1.152" "1.235" "1.092" "1.065" "1.154" "1.090" "1.045" "208.8" "228.0" "245.1" "240.6" "257.9" "228.1" "222.4" "241.0" "227.5" "218.1" "" "" "" "" "" "" "" "" "" "" "195.6" "188.6" "227.5" "186.0" "219.9" "217.9" "203.2" "214.0" "227.5" "210.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3479204083364141985" "False" "High" "IsMasterProtein" "Q96IY1" "Kinetochore-associated protein NSL1 homolog OS=Homo sapiens OX=9606 GN=NSL1 PE=1 SV=3" "0.000" "False" "9.042" "15" "3" "3" "3" "281" "32.1" "6.79" "7.90" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf08641" "25936" "ENSG00000117697" "NSL1" "E7ETD5; hsa:25936; Q5SY75; Q96IY1; Q9H2M5; Q9NRN8; Q9Y415" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.836" "1.026" "0.940" "0.887" "0.900" "0.968" "0.913" "0.848" "0.940" "447.9" "374.2" "459.6" "421.2" "397.5" "403.0" "433.4" "408.8" "379.9" "420.8" "" "" "" "" "" "" "" "" "" "" "419.7" "309.7" "426.7" "325.6" "338.8" "385.1" "396.0" "362.9" "379.9" "405.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-130690685770980429" "False" "High" "IsMasterProtein" "Q9NWS6" "Protein FAM118A OS=Homo sapiens OX=9606 GN=FAM118A PE=1 SV=2" "0.000" "False" "9.037" "10" "3" "3" "3" "357" "40.2" "6.09" "9.70" "3" "" "other membranes" "other molecular function" "Pf13289" "55007" "ENSG00000100376" "FAM118A" "B3KWG4; B4DY02; hsa:55007; Q5TII5; Q96CY3; Q9NWS6" "" "" "0" "0" "1.088" "1.038" "0.999" "1.051" "1.081" "1.005" "0.875" "0.850" "0.964" "154.7" "168.4" "160.6" "154.7" "162.7" "167.3" "155.4" "135.4" "131.6" "149.1" "" "" "" "" "" "" "" "" "" "" "145.0" "139.4" "149.1" "119.6" "138.7" "159.8" "142.0" "120.2" "131.6" "143.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3076278996676727483" "False" "High" "IsMasterProtein" "P53350" "Serine/threonine-protein kinase PLK1 OS=Homo sapiens OX=9606 GN=PLK1 PE=1 SV=1" "0.000" "False" "9.034" "5" "4" "4" "4" "603" "68.2" "8.91" "12.18" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00659" "5347" "ENSG00000166851" "PLK1" "hsa:5347; P53350; Q15153; Q99746" "Cell cycle; Integrated cancer pathway; Androgen receptor network in prostate cancer; TNF-alpha signaling pathway; 22q11.2 copy number variation syndrome; Cohesin complex - Cornelia de Lange syndrome" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Phosphorylation of the APC/C; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; Polo-like kinase mediated events; Activation of NIMA Kinases NEK9, NEK6, NEK7; Mitotic Telophase/Cytokinesis; Phosphorylation of Emi1; Mitotic Metaphase/Anaphase Transition" "30" "0" "1.067" "1.059" "1.095" "1.037" "1.058" "0.973" "0.961" "0.977" "1.066" "595.8" "635.8" "630.9" "652.2" "618.1" "630.1" "579.6" "572.4" "582.3" "635.3" "" "" "" "" "" "" "" "" "" "" "558.3" "526.1" "585.7" "504.1" "526.8" "602.0" "529.6" "508.2" "582.3" "611.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5049018417817342026" "False" "High" "IsMasterProtein" "P09497" "Clathrin light chain B OS=Homo sapiens OX=9606 GN=CLTB PE=1 SV=1" "0.000" "False" "9.031" "8" "3" "4" "3" "229" "25.2" "4.64" "13.21" "3" "transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01086" "1212" "ENSG00000175416" "CLTB" "hsa:1212; P09497; Q53Y37; Q6FHW1" "Ebola virus infection in host; Fragile X syndrome; 5q35 copy number variation" "Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Formation of annular gap junctions" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "908398624639479548" "False" "High" "IsMasterProtein" "P62913" "Large ribosomal subunit protein uL5 OS=Homo sapiens OX=9606 GN=RPL11 PE=1 SV=2" "0.000" "False" "9.029" "21" "4" "4" "4" "178" "20.2" "9.60" "11.34" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00281, Pf00673" "6135" "ENSG00000142676" "RPL11" "hsa:6135; P25121; P39026; P62913; Q8TDH2; Q9Y674" "MET in type 1 papillary renal cell carcinoma; Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Response of EIF2AK4 (GCN2) to amino acid deficiency; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.886" "0.940" "0.874" "0.882" "0.921" "1.052" "0.991" "1.056" "0.915" "776.4" "688.0" "730.0" "678.5" "685.1" "715.5" "816.5" "769.3" "820.2" "710.8" "" "" "" "" "" "" "" "" "" "" "727.5" "569.3" "677.7" "524.5" "584.0" "683.6" "746.1" "683.1" "820.2" "684.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4426217636715391666" "False" "High" "IsMasterProtein" "Q9H9F9" "Actin-related protein 5 OS=Homo sapiens OX=9606 GN=ACTR5 PE=1 SV=2" "0.000" "False" "9.023" "5" "3" "4" "3" "607" "68.3" "5.27" "12.63" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf00022" "79913" "ENSG00000101442" "ACTR5" "hsa:79913; Q86WF7; Q8IUY5; Q8N724; Q9BRN0; Q9BVB7; Q9H9F9" "" "UCH proteinases; DNA Damage Recognition in GG-NER" "2" "0" "1.130" "1.173" "1.126" "1.079" "1.140" "1.115" "1.043" "1.015" "1.098" "253.3" "286.4" "297.3" "285.2" "273.3" "288.7" "282.5" "264.1" "257.1" "278.2" "" "" "" "" "" "" "" "" "" "" "237.4" "237.0" "276.0" "220.4" "232.9" "275.9" "258.1" "234.5" "257.1" "267.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4795865386403905334" "False" "High" "IsMasterProtein" "Q9Y4Z0" "U6 snRNA-associated Sm-like protein LSm4 OS=Homo sapiens OX=9606 GN=LSM4 PE=1 SV=1" "0.000" "False" "9.017" "26" "4" "5" "4" "139" "15.3" "9.99" "14.97" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "25804" "ENSG00000130520" "LSM4" "hsa:25804; Q9Y4Z0" "Ciliary landscape" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "3" "0" "1.011" "1.012" "1.037" "1.018" "1.024" "1.079" "1.040" "0.983" "1.087" "460.3" "465.4" "465.8" "477.2" "468.4" "471.3" "496.8" "478.7" "452.6" "500.4" "" "" "" "" "" "" "" "" "" "" "431.3" "385.1" "432.5" "368.9" "399.3" "450.3" "453.9" "425.1" "452.6" "481.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6979715234218397145" "False" "High" "IsMasterProtein" "Q9BVC3" "Sister chromatid cohesion protein DCC1 OS=Homo sapiens OX=9606 GN=DSCC1 PE=1 SV=2" "0.000" "False" "9.014" "7" "3" "3" "3" "393" "44.8" "5.17" "9.78" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09724" "79075" "ENSG00000136982" "DSCC1" "hsa:79075; Q969N5; Q9BVC3" "Gastric cancer network 2" "Polymerase switching on the C-strand of the telomere" "2" "0" "0.932" "0.953" "1.023" "1.007" "1.060" "0.945" "0.930" "0.987" "1.018" "440.0" "410.3" "419.4" "450.2" "443.1" "466.6" "415.6" "409.1" "434.4" "447.8" "" "" "" "" "" "" "" "" "" "" "412.3" "339.5" "389.4" "348.0" "377.7" "445.7" "379.8" "363.2" "434.4" "431.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7850572796846009162" "False" "High" "IsMasterProtein" "P52435" "DNA-directed RNA polymerase II subunit RPB11-a OS=Homo sapiens OX=9606 GN=POLR2J PE=1 SV=1" "0.000" "False" "9.007" "24" "3" "3" "3" "117" "13.3" "5.86" "9.56" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01193, Pf13656" "5439" "ENSG00000005075" "POLR2J" "A5D6V8; hsa:5439; O43375; P52435" "Pyrimidine metabolism; Eukaryotic transcription initiation" "RNA polymerase II transcribes snRNA genes; TP53 Regulates Transcription of DNA Repair Genes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "43" "0" "1.178" "0.952" "0.947" "1.337" "1.157" "0.957" "1.015" "1.284" "1.077" "98.3" "115.8" "93.6" "93.1" "131.5" "113.8" "94.1" "99.8" "126.2" "105.8" "" "" "" "" "" "" "" "" "" "" "92.1" "95.8" "86.9" "72.0" "112.1" "108.7" "85.9" "88.6" "126.2" "101.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4954031466942572679" "False" "High" "IsMasterProtein" "Q6NW29" "RWD domain-containing protein 4 OS=Homo sapiens OX=9606 GN=RWDD4 PE=1 SV=3" "0.000" "False" "9.006" "15" "3" "3" "3" "188" "21.2" "5.31" "10.87" "3" "" "" "" "Pf05773" "201965" "ENSG00000182552" "RWDD4" "B2RDE9; B4DDP2; hsa:201965; Q6NW29; Q75LA9; Q8WVW2" "" "" "0" "0" "1.056" "1.160" "1.014" "1.090" "1.076" "0.970" "1.043" "1.049" "1.114" "242.2" "255.8" "280.9" "245.6" "263.9" "260.5" "235.1" "252.7" "254.0" "269.9" "" "" "" "" "" "" "" "" "" "" "227.0" "211.7" "260.8" "189.9" "225.0" "248.9" "214.8" "224.3" "254.0" "259.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2146106311129589736" "False" "High" "IsMasterProtein" "P35244" "Replication protein A 14 kDa subunit OS=Homo sapiens OX=9606 GN=RPA3 PE=1 SV=1" "0.000" "False" "9.002" "22" "2" "4" "2" "121" "13.6" "5.08" "12.25" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf08661" "6119" "ENSG00000106399" "RPA3" "hsa:6119; P35244; Q549U6" "Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Meiotic recombination; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "36" "0" "0.967" "1.013" "1.037" "1.184" "1.076" "1.030" "1.141" "1.126" "0.998" "113.0" "109.2" "114.4" "117.2" "133.7" "121.6" "116.3" "128.9" "127.2" "112.7" "" "" "" "" "" "" "" "" "" "" "105.9" "90.4" "106.2" "90.6" "114.0" "116.2" "106.3" "114.4" "127.2" "108.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5119829718007226858" "False" "High" "IsMasterProtein" "Q9UJX5" "Anaphase-promoting complex subunit 4 OS=Homo sapiens OX=9606 GN=ANAPC4 PE=1 SV=2" "0.000" "False" "8.996" "4" "3" "3" "3" "808" "92.1" "5.53" "9.45" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf12894, Pf12896" "29945" "ENSG00000053900" "ANAPC4" "A8K8H1; E9PCR4; hsa:29945; Q6PCC6; Q9NSH6; Q9UJX5" "Cell cycle" "Assembly of the pre-replicative complex; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "0.997" "1.058" "1.064" "1.067" "1.033" "1.130" "1.053" "1.116" "1.096" "347.1" "346.0" "367.2" "369.5" "370.3" "358.5" "392.2" "365.5" "387.4" "380.5" "" "" "" "" "" "" "" "" "" "" "325.3" "286.3" "340.9" "285.6" "315.7" "342.5" "358.4" "324.6" "387.4" "366.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3011469150095823870" "False" "High" "IsMasterProtein" "Q9Y696" "Chloride intracellular channel protein 4 OS=Homo sapiens OX=9606 GN=CLIC4 PE=1 SV=4" "0.000" "False" "8.993" "13" "3" "5" "3" "253" "28.8" "5.59" "16.16" "3" "transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "transporter activity" "Pf13409" "25932" "ENSG00000169504" "CLIC4" "hsa:25932; Q9UFW9; Q9UQJ6; Q9Y696" "" "" "0" "0" "0.947" "0.994" "0.960" "1.012" "0.990" "0.970" "1.041" "0.987" "1.003" "561.4" "531.8" "558.1" "538.9" "568.2" "555.9" "544.3" "584.6" "554.0" "563.2" "" "" "" "" "" "" "" "" "" "" "526.1" "440.0" "518.1" "416.6" "484.3" "531.1" "497.4" "519.1" "554.0" "542.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "779708130048871486" "False" "High" "IsMasterProtein" "O43464" "Serine protease HTRA2, mitochondrial OS=Homo sapiens OX=9606 GN=HTRA2 PE=1 SV=2" "0.000" "False" "8.987" "7" "3" "3" "3" "458" "48.8" "10.07" "9.48" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf13365, Pf17820" "27429" "ENSG00000115317" "HTRA2" "hsa:27429; O43464; Q9HBZ4; Q9P0Y3; Q9P0Y4" "Apoptosis modulation and signaling; Parkinson's disease pathway; Nanomaterial induced apoptosis; Ciliary landscape; Complement system in neuronal development and plasticity" "Mitochondrial protein degradation" "6" "0" "1.018" "0.963" "1.078" "1.080" "1.067" "1.096" "0.961" "0.952" "1.023" "244.5" "249.0" "235.4" "263.5" "264.2" "261.0" "268.0" "234.9" "232.8" "250.2" "" "" "" "" "" "" "" "" "" "" "229.1" "206.0" "218.6" "203.7" "225.2" "249.3" "244.9" "208.5" "232.8" "240.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3836342718594531018" "False" "High" "IsMasterProtein" "O94921" "Cyclin-dependent kinase 14 OS=Homo sapiens OX=9606 GN=CDK14 PE=1 SV=3" "0.000" "False" "8.977" "7" "4" "5" "3" "469" "53.0" "8.92" "13.82" "4" "cell-cell signaling;cell cycle OR cell proliferation;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5218" "ENSG00000058091" "CDK14" "A4D1E6; A6NK51; A8WFP6; B4DHG5; B4DNM2; hsa:5218; O94921; Q75N06; Q75N22; Q8N764; Q9H3D7; Q9UDR0" "" "" "0" "0" "0.976" "1.103" "1.119" "1.120" "1.057" "0.991" "1.015" "1.022" "1.025" "269.7" "263.1" "297.5" "301.7" "302.1" "284.9" "267.4" "273.7" "275.7" "276.4" "" "" "" "" "" "" "" "" "" "" "252.7" "217.7" "276.2" "233.2" "257.5" "272.2" "244.3" "243.0" "275.7" "266.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6636555355274069790" "False" "High" "IsMasterProtein" "Q9Y5J9" "Mitochondrial import inner membrane translocase subunit Tim8 B OS=Homo sapiens OX=9606 GN=TIMM8B PE=1 SV=1" "0.000" "False" "8.964" "31" "3" "4" "3" "83" "9.3" "5.12" "11.87" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02953" "26521" "ENSG00000150779" "TIMM8B" "B0YJA5; hsa:26521; Q3KQS9; Q9UN04; Q9Y5J9" "" "Mitochondrial protein import" "1" "0" "1.086" "1.020" "0.939" "0.999" "1.013" "0.919" "1.008" "0.965" "0.997" "413.1" "448.7" "421.2" "387.9" "412.6" "418.5" "379.7" "416.3" "398.5" "412.1" "" "" "" "" "" "" "" "" "" "" "387.1" "371.3" "391.1" "299.9" "351.6" "399.9" "347.0" "369.7" "398.5" "396.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3946386613732823747" "False" "High" "IsMasterProtein" "Q8WXD5" "Gem-associated protein 6 OS=Homo sapiens OX=9606 GN=GEMIN6 PE=1 SV=1" "0.000" "False" "8.955" "22" "3" "3" "3" "167" "18.8" "5.12" "10.11" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf06372, Pf20417" "79833" "ENSG00000152147" "GEMIN6" "B2RDP8; hsa:79833; Q53SI5; Q8WVB4; Q8WXD5; Q9H5G6" "" "SARS-CoV-2 modulates host translation machinery; snRNP Assembly" "2" "0" "0.954" "0.923" "0.995" "1.027" "0.960" "0.943" "0.933" "0.880" "0.992" "493.3" "470.6" "455.3" "490.9" "506.8" "473.4" "465.4" "460.3" "434.1" "489.5" "" "" "" "" "" "" "" "" "" "" "462.2" "389.4" "422.6" "379.5" "432.0" "452.2" "425.3" "408.7" "434.1" "471.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "460406497697363824" "False" "High" "IsMasterProtein" "P61018" "Ras-related protein Rab-4B OS=Homo sapiens OX=9606 GN=RAB4B PE=1 SV=1" "0.000" "False" "8.954" "14" "3" "4" "1" "213" "23.6" "6.06" "12.30" "3" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "53916" "ENSG00000167578" "RAB4B" "hsa:53916; P22750; P61018; Q7Z514; Q9HBR6" "Intracellular trafficking proteins involved in CMT neuropathy" "Neutrophil degranulation; RAB geranylgeranylation; MET receptor recycling" "4" "0" "1.034" "1.025" "1.052" "1.201" "0.925" "1.030" "1.079" "1.037" "1.056" "166.3" "171.9" "170.5" "174.9" "199.8" "153.9" "171.4" "179.4" "172.5" "175.7" "" "" "" "" "" "" "" "" "" "" "155.9" "142.3" "158.2" "135.2" "170.3" "147.0" "156.6" "159.3" "172.5" "169.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1761615694951134021" "False" "High" "IsMasterProtein" "P62888" "Large ribosomal subunit protein eL30 OS=Homo sapiens OX=9606 GN=RPL30 PE=1 SV=2" "0.000" "False" "8.953" "29" "3" "5" "3" "115" "12.8" "9.63" "16.32" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6156" "ENSG00000156482" "RPL30" "B2R591; hsa:6156; P04645; P62888; Q502Z6" "Selenium metabolism and selenoproteins; Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.038" "1.014" "1.082" "1.167" "1.072" "1.276" "1.366" "1.223" "1.120" "827.5" "858.7" "839.1" "895.2" "965.3" "887.2" "1056.2" "1130.8" "1012.2" "926.7" "" "" "" "" "" "" "" "" "" "" "775.4" "710.6" "779.0" "692.0" "822.8" "847.7" "965.1" "1004.0" "1012.2" "892.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4633988099481439098" "False" "High" "IsMasterProtein" "Q9Y5T5" "Ubiquitin carboxyl-terminal hydrolase 16 OS=Homo sapiens OX=9606 GN=USP16 PE=1 SV=1" "0.000" "False" "8.952" "3" "3" "3" "3" "823" "93.5" "6.93" "7.99" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "translation activity;other molecular function" "Pf00443, Pf02148" "10600" "ENSG00000156256; ENSG00000291527" "USP16" "A8MU43; B3KN13; B4DFV8; B4DY37; D3DSD9; hsa:10600; Q53GP7; Q53HA0; Q5VKN8; Q8NEL3; Q9H3E6; Q9Y5T5" "" "Ub-specific processing proteases" "1" "0" "0.922" "0.990" "0.920" "0.911" "0.932" "0.913" "0.915" "0.863" "0.944" "272.5" "251.3" "269.7" "250.6" "248.1" "254.0" "248.8" "249.4" "235.3" "257.1" "" "" "" "" "" "" "" "" "" "" "255.3" "207.9" "250.4" "193.7" "211.5" "242.7" "227.3" "221.4" "235.3" "247.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1753263337049179801" "False" "High" "IsMasterProtein" "O75808" "Calpain-15 OS=Homo sapiens OX=9606 GN=CAPN15 PE=1 SV=1" "0.000" "False" "8.950" "3" "3" "5" "3" "1086" "117.2" "6.71" "12.95" "3" "protein metabolism" "other cell component" "other molecular function" "Pf00641, Pf00648" "6650" "ENSG00000103326" "CAPN15" "B1B1M4; hsa:6650; O75808; Q2KHS2; Q8WTY9; Q9BUW0" "" "Degradation of the extracellular matrix" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "215729870143927910" "False" "High" "IsMasterProtein" "P52815" "Large ribosomal subunit protein bL12m OS=Homo sapiens OX=9606 GN=MRPL12 PE=1 SV=2" "0.000" "False" "8.940" "18" "3" "4" "3" "198" "21.3" "8.87" "14.07" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00542, Pf16320" "6182" "ENSG00000262814" "MRPL12" "hsa:6182; P52815; Q969U0; Q9HCA2; Q9UQJ3" "" "Mitochondrial protein degradation; Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "1.053" "1.032" "1.136" "1.145" "1.162" "1.027" "1.118" "1.143" "1.188" "402.4" "423.5" "415.2" "457.3" "460.6" "467.6" "413.1" "449.8" "460.0" "478.1" "" "" "" "" "" "" "" "" "" "" "377.0" "350.5" "385.5" "353.5" "392.6" "446.8" "377.5" "399.3" "460.0" "460.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1292677114640833852" "False" "High" "IsMasterProtein" "Q5VZL5" "Zinc finger MYM-type protein 4 OS=Homo sapiens OX=9606 GN=ZMYM4 PE=1 SV=1" "0.000" "False" "8.939" "2" "5" "5" "4" "1548" "172.7" "6.84" "13.67" "5" "cell organization and biogenesis;other biological processes" "" "nucleic acid binding activity;other molecular function" "Pf06467, Pf12012" "9202" "ENSG00000146463" "ZMYM4" "A0JP19; A0JP20; hsa:9202; O43308; Q5T5E1; Q5T5E2; Q5VZL5; Q7L3Q4" "" "" "0" "0" "1.071" "0.997" "1.069" "1.056" "1.144" "1.320" "1.227" "1.273" "1.171" "386.9" "414.3" "385.7" "413.8" "408.4" "442.7" "510.7" "474.7" "492.6" "452.9" "" "" "" "" "" "" "" "" "" "" "362.5" "342.9" "358.1" "319.9" "348.1" "423.0" "466.6" "421.5" "492.6" "436.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1949176893953303809" "False" "High" "IsMasterProtein" "Q9NZZ3" "Charged multivesicular body protein 5 OS=Homo sapiens OX=9606 GN=CHMP5 PE=1 SV=1" "0.000" "False" "8.935" "18" "3" "5" "3" "219" "24.6" "4.83" "14.65" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf03357" "51510" "ENSG00000086065" "CHMP5" "B2RD95; B4DIR6; hsa:51510; Q5VXW2; Q96AV2; Q9HB68; Q9NYS4; Q9NZZ3; Q9Y323" "Ferroptosis" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "3" "0" "0.957" "1.038" "1.133" "1.059" "0.983" "1.015" "0.962" "1.019" "1.027" "127.2" "121.7" "132.1" "144.2" "134.8" "125.0" "129.1" "122.4" "129.6" "130.6" "" "" "" "" "" "" "" "" "" "" "119.2" "100.7" "122.6" "111.4" "114.9" "119.4" "118.0" "108.7" "129.6" "125.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5327705833801287144" "False" "High" "IsMasterProtein" "Q96EP0" "E3 ubiquitin-protein ligase RNF31 OS=Homo sapiens OX=9606 GN=RNF31 PE=1 SV=1" "0.000" "False" "8.931" "3" "3" "3" "3" "1072" "119.6" "6.57" "6.24" "3" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01485, Pf09409, Pf16678, Pf18091, Pf18486" "55072" "ENSG00000092098; ENSG00000285152" "RNF31" "A0A962; Q86VI2; Q8TEI0; Q96EP0; Q96GB4; Q96NF1; Q9H5F1; Q9NWD2" "" "Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9028171991778450679" "False" "High" "IsMasterProtein" "P27540" "Aryl hydrocarbon receptor nuclear translocator OS=Homo sapiens OX=9606 GN=ARNT PE=1 SV=1" "0.000" "False" "8.931" "4" "3" "3" "3" "789" "86.6" "6.54" "8.94" "3" "stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00010, Pf00989, Pf14598" "405" "ENSG00000143437" "ARNT" "B2R9H1; C4AMA1; F8WAP6; hsa:405; P27540; Q59ED4; Q5QP39; Q8NDC7" "Angiogenesis; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Type 2 papillary renal cell carcinoma; 6q16 copy number variation" "PPARA activates gene expression; NPAS4 regulates expression of target genes; Endogenous sterols; Xenobiotics; Aryl hydrocarbon receptor signalling; Regulation of gene expression by Hypoxia-inducible Factor" "16" "0" "1.070" "0.971" "1.000" "1.047" "0.970" "0.958" "0.951" "0.999" "0.997" "174.3" "186.4" "169.2" "174.3" "182.5" "169.0" "167.0" "165.8" "174.1" "173.7" "" "" "" "" "" "" "" "" "" "" "163.3" "154.3" "157.1" "134.8" "155.6" "161.4" "152.6" "147.2" "174.1" "167.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3674026765185109736" "False" "High" "IsMasterProtein" "Q6EEV6" "Small ubiquitin-related modifier 4 OS=Homo sapiens OX=9606 GN=SUMO4 PE=1 SV=3" "0.000" "False" "8.917" "23" "2" "4" "1" "95" "10.6" "7.18" "14.99" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11976" "387082" "ENSG00000177688" "SUMO4" "A1L3W5; hsa:387082; Q6EEV6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6512701136026714686" "False" "High" "IsMasterProtein" "O95379" "Tumor necrosis factor alpha-induced protein 8 OS=Homo sapiens OX=9606 GN=TNFAIP8 PE=1 SV=1" "0.000" "False" "8.899" "15" "3" "5" "3" "198" "23.0" "7.93" "14.93" "3" "other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf05527" "25816" "ENSG00000145779" "TNFAIP8" "B3KMH1; B3KMI2; B7Z713; hsa:25816; O95379; Q9P1Q1; Q9UER5; Q9UP47" "" "PI Metabolism" "1" "0" "0.905" "0.963" "0.992" "0.970" "1.000" "0.898" "0.963" "0.967" "0.989" "690.8" "625.2" "665.0" "685.5" "669.9" "691.0" "620.4" "665.0" "668.0" "683.4" "" "" "" "" "" "" "" "" "" "" "647.3" "517.3" "617.4" "529.9" "571.0" "660.2" "566.9" "590.4" "668.0" "658.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3889272514054364250" "False" "High" "IsMasterProtein" "O15541" "E3 ubiquitin-protein ligase RNF113A OS=Homo sapiens OX=9606 GN=RNF113A PE=1 SV=1" "0.000" "False" "8.886" "13" "3" "4" "3" "343" "38.8" "5.69" "10.06" "3" "protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00642, Pf13920" "7737" "ENSG00000125352" "RNF113A" "B2RBR7; hsa:7737; O15541" "" "mRNA Splicing - Major Pathway" "1" "0" "0.948" "1.204" "1.224" "1.022" "1.061" "1.161" "1.224" "1.062" "1.081" "57.6" "54.6" "69.3" "70.5" "58.9" "61.1" "66.9" "70.5" "61.2" "62.3" "" "" "" "" "" "" "" "" "" "" "54.0" "45.2" "64.4" "54.5" "50.2" "58.4" "61.1" "62.6" "61.2" "60.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1812058185286656363" "False" "High" "IsMasterProtein" "Q9NWZ8" "Gem-associated protein 8 OS=Homo sapiens OX=9606 GN=GEMIN8 PE=1 SV=1" "0.000" "False" "8.879" "12" "3" "4" "3" "242" "28.6" "6.80" "10.85" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf15348" "54960" "ENSG00000046647" "GEMIN8" "C4AMC4; hsa:54960; Q2LJ66; Q6ZV27; Q9NWZ8" "" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "2" "0" "1.047" "0.959" "1.022" "0.990" "0.986" "1.024" "0.961" "0.906" "0.969" "261.0" "273.1" "250.2" "266.7" "258.2" "257.2" "267.2" "250.7" "236.5" "253.0" "" "" "" "" "" "" "" "" "" "" "244.5" "226.0" "232.3" "206.2" "220.1" "245.7" "244.2" "222.6" "236.5" "243.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1610110799858015964" "False" "High" "IsMasterProtein" "P20674" "Cytochrome c oxidase subunit 5A, mitochondrial OS=Homo sapiens OX=9606 GN=COX5A PE=1 SV=2" "0.000" "False" "8.878" "21" "3" "4" "3" "150" "16.8" "6.79" "11.47" "3" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02284" "9377" "ENSG00000178741" "COX5A" "hsa:9377; P20674; P30045; Q8TB65" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation; Arachidonate epoxygenase / epoxide hydrolase" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial protein degradation" "9" "0" "1.174" "1.066" "1.167" "1.100" "1.229" "1.158" "1.133" "1.102" "1.160" "169.0" "198.4" "180.1" "197.2" "185.9" "207.6" "195.7" "191.4" "186.3" "196.0" "" "" "" "" "" "" "" "" "" "" "158.3" "164.2" "167.2" "152.4" "158.4" "198.3" "178.8" "170.0" "186.3" "188.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8489357358395881882" "False" "High" "IsMasterProtein" "Q86SX6" "Glutaredoxin-related protein 5, mitochondrial OS=Homo sapiens OX=9606 GN=GLRX5 PE=1 SV=2" "0.000" "False" "8.874" "25" "3" "4" "3" "157" "16.6" "6.79" "12.90" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00462" "51218" "ENSG00000182512" "GLRX5" "hsa:51218; Q0X088; Q3YML0; Q86SX6; Q86WY3; Q8IZ54" "Iron-sulfur cluster biogenesis" "Mitochondrial iron-sulfur cluster biogenesis" "2" "0" "1.066" "0.999" "1.046" "1.019" "1.023" "1.092" "1.009" "0.908" "0.958" "126.3" "134.6" "126.3" "132.1" "128.7" "129.2" "137.9" "127.4" "114.7" "121.0" "" "" "" "" "" "" "" "" "" "" "118.4" "111.4" "117.2" "102.1" "109.7" "123.5" "126.0" "113.2" "114.7" "116.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6535864909566568035" "False" "High" "IsMasterProtein" "O75367" "Core histone macro-H2A.1 OS=Homo sapiens OX=9606 GN=MACROH2A1 PE=1 SV=5" "0.000" "False" "8.874" "8" "3" "4" "3" "369" "39.2" "9.83" "14.52" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00125, Pf01661, Pf16211" "9555" "ENSG00000113648" "MACROH2A1" "hsa:9555; O75367; O75377; Q503A8; Q7Z5E3; Q96D41; Q9H8P3; Q9UP96" "H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "" "2" "0" "1.067" "1.010" "1.109" "1.101" "1.056" "1.259" "1.255" "1.236" "1.096" "354.5" "378.4" "357.9" "393.1" "390.2" "374.5" "446.3" "444.8" "438.4" "388.7" "" "" "" "" "" "" "" "" "" "" "332.2" "313.1" "332.3" "303.9" "332.6" "357.8" "407.8" "395.0" "438.4" "374.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1414945439185658993" "False" "High" "IsMasterProtein" "P84090" "Enhancer of rudimentary homolog OS=Homo sapiens OX=9606 GN=ERH PE=1 SV=1" "0.000" "False" "8.870" "34" "3" "3" "3" "104" "12.3" "5.92" "10.80" "3" "cell cycle OR cell proliferation;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01133" "2079" "ENSG00000100632" "ERH" "B2R5H2; hsa:2079; P70659; P84090; Q14259" "" "" "0" "0" "1.129" "1.078" "1.222" "1.121" "0.995" "1.075" "1.410" "1.255" "1.151" "568.3" "641.8" "612.5" "694.5" "636.8" "565.3" "611.0" "801.2" "713.0" "654.3" "" "" "" "" "" "" "" "" "" "" "532.5" "531.1" "568.6" "536.8" "542.8" "540.1" "558.3" "711.4" "713.0" "630.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2919844003918088189" "False" "High" "IsMasterProtein" "Q9P215" "Pogo transposable element with KRAB domain OS=Homo sapiens OX=9606 GN=POGK PE=1 SV=2" "0.000" "False" "8.869" "6" "4" "4" "4" "609" "69.4" "5.14" "11.31" "4" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf01352, Pf03184, Pf03221, Pf09607" "57645" "ENSG00000143157" "POGK" "hsa:57645; Q5TIJ1; Q8TE07; Q9P215" "" "" "0" "0" "0.918" "0.989" "0.955" "0.984" "0.999" "0.860" "0.856" "0.910" "1.021" "1162.7" "1066.8" "1149.4" "1110.2" "1144.5" "1161.3" "1000.1" "995.5" "1057.8" "1186.7" "" "" "" "" "" "" "" "" "" "" "1089.4" "882.8" "1067.0" "858.2" "975.6" "1109.5" "913.8" "883.9" "1057.8" "1142.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-932703795777546839" "False" "High" "IsMasterProtein" "Q96BJ3" "Axin interactor, dorsalization-associated protein OS=Homo sapiens OX=9606 GN=AIDA PE=1 SV=1" "0.000" "False" "8.848" "11" "3" "3" "3" "306" "35.0" "6.55" "10.49" "3" "developmental processes;other biological processes" "other membranes;other cell component" "other molecular function" "Pf08910, Pf14186" "64853" "ENSG00000186063" "AIDA" "A8K1F0; hsa:64853; Q49A81; Q5JRA4; Q658P1; Q96BJ3; Q9H9E8" "" "" "0" "0" "1.046" "1.072" "0.952" "1.107" "1.131" "0.967" "1.073" "1.148" "1.055" "351.0" "367.2" "376.1" "334.0" "388.5" "397.1" "339.4" "376.5" "402.9" "370.1" "" "" "" "" "" "" "" "" "" "" "328.8" "303.8" "349.2" "258.2" "331.2" "379.4" "310.1" "334.3" "402.9" "356.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3246140782840633700" "False" "High" "IsMasterProtein" "Q96B01" "RAD51-associated protein 1 OS=Homo sapiens OX=9606 GN=RAD51AP1 PE=1 SV=1" "0.000" "False" "8.830" "11" "4" "4" "4" "352" "38.4" "9.11" "11.64" "4" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf15696" "10635" "ENSG00000111247" "RAD51AP1" "A8K7D3; hsa:10635; O43403; Q7Z779; Q96B01" "" "Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange; Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2" "8" "0" "1.114" "0.930" "0.956" "1.033" "1.035" "1.041" "1.091" "1.075" "1.074" "517.9" "577.1" "481.6" "495.2" "535.1" "536.2" "539.0" "565.0" "556.6" "556.5" "" "" "" "" "" "" "" "" "" "" "485.3" "477.6" "447.1" "382.8" "456.1" "512.3" "492.5" "501.7" "556.6" "535.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4405181458594490981" "False" "High" "IsMasterProtein" "Q9NYL2" "Mitogen-activated protein kinase kinase kinase 20 OS=Homo sapiens OX=9606 GN=MAP3K20 PE=1 SV=3" "0.000" "False" "8.830" "4" "3" "3" "3" "800" "91.1" "7.87" "6.89" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00536, Pf07714" "51776" "ENSG00000091436" "MAP3K20" "B3KPG2; hsa:51776; Q53SX1; Q580W8; Q59GY5; Q86YW8; Q9HCC4; Q9HCC5; Q9HDD2; Q9NYE9; Q9NYL2" "MAPK signaling pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6403678717829717744" "False" "High" "IsMasterProtein" "Q9H3K6" "BolA-like protein 2 OS=Homo sapiens OX=9606 GN=BOLA2B PE=1 SV=1" "0.000" "False" "8.829" "37" "3" "5" "3" "86" "10.1" "6.52" "17.35" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01722" "552900; 654483" "ENSG00000169627; ENSG00000183336" "BOLA2; BOLA2B" "A1L454; A7YDY3; hsa:552900; hsa:654483; Q9H3K6" "" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "1" "0" "1.012" "0.916" "1.017" "0.969" "0.938" "0.929" "0.992" "0.887" "0.905" "761.4" "770.8" "697.8" "774.3" "737.9" "714.0" "707.5" "755.0" "675.0" "689.1" "" "" "" "" "" "" "" "" "" "" "713.5" "637.8" "647.8" "598.6" "629.0" "682.2" "646.4" "670.3" "675.0" "663.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4321447803487511562" "False" "High" "IsMasterProtein" "Q8NEZ2" "Vacuolar protein sorting-associated protein 37A OS=Homo sapiens OX=9606 GN=VPS37A PE=1 SV=1" "0.000" "False" "8.828" "10" "3" "3" "3" "397" "44.3" "5.57" "11.29" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf07200" "137492" "ENSG00000155975" "VPS37A" "hsa:137492; Q336D5; Q6NW27; Q8N3D7; Q8NEZ2; Q8TBL7; Q96DL9" "7q11.23 copy number variation syndrome" "Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy" "6" "0" "1.277" "1.128" "1.361" "1.253" "1.232" "1.193" "1.723" "1.223" "1.954" "116.8" "149.1" "131.8" "159.0" "146.3" "143.9" "139.3" "201.2" "142.8" "228.3" "" "" "" "" "" "" "" "" "" "" "109.4" "123.4" "122.4" "122.9" "124.7" "137.4" "127.3" "178.6" "142.8" "219.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-781411655815037660" "False" "High" "IsMasterProtein" "P14316" "Interferon regulatory factor 2 OS=Homo sapiens OX=9606 GN=IRF2 PE=1 SV=2" "0.000" "False" "8.821" "9" "4" "6" "4" "349" "39.3" "7.52" "16.88" "4" "cell cycle OR cell proliferation;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605" "3660" "ENSG00000168310" "IRF2" "D6RCK5; H0Y8S3; hsa:3660; P14316; Q6IAS7; Q96B99" "Apoptosis; Rubinstein-Taybi syndrome 1; Type II interferon signaling" "Interferon gamma signaling; Factors involved in megakaryocyte development and platelet production; Interferon alpha/beta signaling; Pyroptosis" "7" "0" "0.997" "1.037" "1.025" "1.034" "1.000" "0.998" "1.025" "0.958" "0.978" "668.8" "666.8" "693.3" "685.6" "691.6" "668.6" "667.2" "685.6" "640.9" "653.8" "" "" "" "" "" "" "" "" "" "" "626.6" "551.8" "643.6" "530.0" "589.5" "638.8" "609.6" "608.8" "640.9" "629.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7415946790012265046" "False" "High" "IsMasterProtein" "O75586" "Mediator of RNA polymerase II transcription subunit 6 OS=Homo sapiens OX=9606 GN=MED6 PE=1 SV=2" "0.000" "False" "8.821" "10" "3" "6" "3" "246" "28.4" "8.62" "16.91" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04934" "10001" "ENSG00000133997" "MED6" "B4DU17; B4E2P0; hsa:10001; O15401; O75586; Q53FE3; Q53HJ3; Q6FHQ4; Q9BTH1; Q9UHL1" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "0.969" "0.997" "1.096" "1.109" "1.118" "1.032" "1.114" "0.972" "1.035" "632.7" "612.9" "630.8" "693.4" "701.5" "707.2" "652.8" "704.7" "615.0" "655.0" "" "" "" "" "" "" "" "" "" "" "592.9" "507.2" "585.6" "536.1" "597.9" "675.6" "596.5" "625.7" "615.0" "630.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3684476333316036577" "False" "High" "IsMasterProtein" "Q5R372" "Rab GTPase-activating protein 1-like OS=Homo sapiens OX=9606 GN=RABGAP1L PE=1 SV=1" "0.000" "False" "8.819" "4" "3" "3" "3" "815" "92.5" "5.31" "11.11" "3" "transport;other biological processes" "ER/Golgi;nucleus;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00566, Pf00640, Pf12473" "9910" "ENSG00000152061" "RABGAP1L" "O75059; Q3ZTR8; Q5R369; Q5R372; Q8IVV0; Q8N921; Q8WV78; Q9NSP8; Q9UQ19; Q9UQP5; Q9Y6Y5; Q9Y6Y6" "" "" "0" "0" "1.024" "0.996" "1.163" "1.066" "1.114" "1.016" "1.047" "1.032" "1.074" "248.8" "254.9" "247.9" "289.4" "265.3" "277.2" "252.7" "260.5" "256.7" "267.2" "" "" "" "" "" "" "" "" "" "" "233.1" "210.9" "230.1" "223.7" "226.1" "264.8" "230.9" "231.3" "256.7" "257.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4492999109905159377" "False" "High" "IsMasterProtein" "Q15121" "Astrocytic phosphoprotein PEA-15 OS=Homo sapiens OX=9606 GN=PEA15 PE=1 SV=2" "0.000" "False" "8.812" "22" "3" "3" "3" "130" "15.0" "5.02" "10.14" "3" "transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf01335" "8682" "ENSG00000162734" "PEA15" "B1AKZ3; hsa:8682; O00511; Q15121" "Apoptosis modulation and signaling" "RAF/MAP kinase cascade; RAF-independent MAPK1/3 activation" "3" "0" "1.033" "1.007" "0.865" "0.925" "0.898" "0.845" "0.824" "0.838" "0.874" "1000.5" "1033.2" "1007.1" "865.8" "925.0" "898.1" "845.2" "824.7" "838.8" "874.0" "" "" "" "" "" "" "" "" "" "" "937.5" "855.0" "935.0" "669.3" "788.5" "858.1" "772.3" "732.2" "838.8" "841.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1450384486208506068" "False" "High" "IsMasterProtein" "Q96LD4" "E3 ubiquitin-protein ligase TRIM47 OS=Homo sapiens OX=9606 GN=TRIM47 PE=1 SV=2" "0.000" "False" "8.799" "7" "3" "4" "3" "638" "69.5" "6.44" "13.55" "3" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00643, Pf13445" "91107" "ENSG00000132481" "TRIM47" "hsa:91107; Q96AD0; Q96GU5; Q96LD4; Q9BRN7" "" "" "0" "0" "0.925" "0.867" "0.925" "0.942" "0.878" "0.898" "0.830" "0.943" "1.019" "71.9" "66.5" "62.3" "66.5" "67.7" "63.1" "64.5" "59.6" "67.8" "73.2" "" "" "" "" "" "" "" "" "" "" "67.3" "55.0" "57.9" "51.4" "57.7" "60.3" "59.0" "52.9" "67.8" "70.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1136276274869286846" "False" "High" "IsMasterProtein" "Q9NVR2" "Integrator complex subunit 10 OS=Homo sapiens OX=9606 GN=INTS10 PE=1 SV=2" "0.000" "False" "8.780" "4" "3" "3" "3" "710" "82.2" "7.44" "9.92" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf21045" "55174" "ENSG00000104613" "INTS10" "hsa:55174; Q6IA93; Q7L538; Q7L8C8; Q9H3W8; Q9NVR2" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.100" "1.109" "0.989" "1.076" "0.996" "0.997" "1.059" "1.151" "1.021" "118.6" "130.5" "131.6" "117.3" "127.6" "118.2" "118.2" "125.7" "136.5" "121.2" "" "" "" "" "" "" "" "" "" "" "111.2" "108.0" "122.2" "90.7" "108.8" "112.9" "108.0" "111.6" "136.5" "116.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "755217233260055713" "False" "High" "IsMasterProtein" "O95786" "Antiviral innate immune response receptor RIG-I OS=Homo sapiens OX=9606 GN=RIGI PE=1 SV=2" "0.000" "False" "8.779" "4" "4" "4" "4" "925" "106.5" "6.40" "11.90" "4" "other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf11648, Pf16739, Pf18119" "23586" "ENSG00000107201" "RIGI" "A2RU81; hsa:23586; O95786; Q5HYE1; Q5VYT1; Q9NT04" "Novel intracellular components of RIG-I-like receptor pathway; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Pathways of nucleic acid metabolism and innate immune sensing; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19" "RSV-host interactions; Ub-specific processing proteases; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; OAS antiviral response; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Negative regulators of DDX58/IFIH1 signaling; SARS-CoV-1 activates/modulates innate immune responses; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses" "27" "0" "1.023" "0.977" "1.056" "1.016" "0.994" "0.988" "0.929" "0.993" "0.977" "508.8" "520.8" "497.0" "537.5" "517.1" "505.8" "502.8" "473.0" "505.2" "497.3" "" "" "" "" "" "" "" "" "" "" "476.8" "430.9" "461.4" "415.5" "440.8" "483.3" "459.5" "419.9" "505.2" "478.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9041642715196390420" "False" "High" "IsMasterProtein" "Q7L7L0" "Histone H2A type 3 OS=Homo sapiens OX=9606 GN=H2AC25 PE=1 SV=3" "0.000" "False" "8.770" "23" "4" "6" "1" "130" "14.1" "11.05" "13.69" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "92815" "ENSG00000181218; ENSG00000284841" "H2AC25" "B2R4S4; hsa:92815; Q7L7L0" "" "Ub-specific processing proteases; HCMV Late Events; UCH proteinases; HCMV Early Events; HDACs deacetylate histones; Metalloprotease DUBs; RMTs methylate histone arginines; HATs acetylate histones" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2129800861400375686" "False" "High" "IsMasterProtein" "O60220" "Mitochondrial import inner membrane translocase subunit Tim8 A OS=Homo sapiens OX=9606 GN=TIMM8A PE=1 SV=1" "0.000" "False" "8.768" "23" "2" "4" "2" "97" "11.0" "5.16" "8.24" "2" "cell organization and biogenesis;transport;developmental processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "1678" "ENSG00000126953" "TIMM8A" "B2R5A6; O60220; Q6IRW6" "" "Mitochondrial protein import" "1" "0" "1.131" "1.014" "0.851" "0.951" "0.924" "0.904" "0.908" "0.959" "0.939" "230.9" "261.2" "234.0" "196.6" "219.5" "213.3" "208.7" "209.6" "221.3" "216.9" "" "" "" "" "" "" "" "" "" "" "216.3" "216.2" "217.3" "151.9" "187.1" "203.8" "190.7" "186.1" "221.3" "208.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6627286514823912553" "False" "High" "IsMasterProtein" "Q8TEA1" "tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 OS=Homo sapiens OX=9606 GN=NSUN6 PE=1 SV=1" "0.000" "False" "8.763" "6" "3" "4" "3" "469" "51.7" "7.96" "12.15" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01189" "221078" "ENSG00000241058" "NSUN6" "B0YJ54; hsa:221078; Q8TEA1" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.838" "0.980" "1.217" "1.277" "1.356" "1.190" "0.967" "1.215" "1.082" "251.4" "462.1" "246.3" "306.0" "321.0" "340.9" "299.3" "243.2" "305.4" "272.2" "" "" "" "" "" "" "" "" "" "" "235.6" "382.4" "228.7" "236.6" "273.6" "325.7" "273.5" "215.9" "305.4" "262.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4329245545062110439" "False" "High" "IsMasterProtein" "Q9NQ50" "Large ribosomal subunit protein mL40 OS=Homo sapiens OX=9606 GN=MRPL40 PE=1 SV=1" "0.000" "False" "8.742" "14" "3" "6" "3" "206" "24.5" "9.63" "20.67" "3" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf09812" "64976" "ENSG00000185608" "MRPL40" "B3KVZ7; hsa:64976; O95134; Q9NQ50" "22q11.2 copy number variation syndrome" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "1.088" "1.078" "1.085" "1.122" "1.170" "1.032" "1.239" "1.180" "1.135" "360.2" "391.9" "388.4" "390.9" "404.0" "421.4" "371.8" "446.3" "425.1" "409.0" "" "" "" "" "" "" "" "" "" "" "337.5" "324.3" "360.5" "302.1" "344.3" "402.6" "339.7" "396.2" "425.1" "393.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6978047849896927875" "False" "High" "IsMasterProtein" "O15234" "Protein CASC3 OS=Homo sapiens OX=9606 GN=CASC3 PE=1 SV=2" "0.000" "False" "8.741" "4" "4" "5" "4" "703" "76.2" "6.48" "14.91" "4" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09405" "22794" "ENSG00000108349" "CASC3" "A8K8R0; O15234" "" "Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "6" "0" "1.162" "1.054" "1.112" "1.148" "0.995" "1.058" "0.972" "0.938" "0.990" "116.7" "135.6" "123.0" "129.8" "134.0" "116.1" "123.5" "113.4" "109.4" "115.5" "" "" "" "" "" "" "" "" "" "" "109.3" "112.2" "114.2" "100.3" "114.2" "110.9" "112.9" "100.7" "109.4" "111.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8429981221702182893" "False" "High" "IsMasterProtein" "P20340" "Ras-related protein Rab-6A OS=Homo sapiens OX=9606 GN=RAB6A PE=1 SV=3" "0.000" "False" "8.736" "16" "3" "4" "2" "208" "23.6" "5.54" "12.51" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "5870" "ENSG00000175582" "RAB6A" "A8K133; B7Z772; F5H668; hsa:5870; P20340; Q1W5D8; Q5U0A8; Q9UBE4" "" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; COPI-independent Golgi-to-ER retrograde traffic; Pre-NOTCH Processing in Golgi; Retrograde transport at the Trans-Golgi-Network; TBC/RABGAPs" "7" "0" "1.003" "1.060" "1.269" "1.149" "1.106" "1.195" "1.133" "1.158" "1.144" "126.7" "127.1" "134.2" "160.7" "145.6" "140.1" "151.4" "143.5" "146.7" "144.9" "" "" "" "" "" "" "" "" "" "" "118.7" "105.2" "124.6" "124.2" "124.1" "133.8" "138.3" "127.4" "146.7" "139.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4482584710342815386" "False" "High" "IsMasterProtein" "Q15773" "Myeloid leukemia factor 2 OS=Homo sapiens OX=9606 GN=MLF2 PE=1 SV=1" "0.000" "False" "8.727" "16" "3" "3" "3" "248" "28.1" "6.90" "11.30" "3" "other biological processes" "nucleus;other cell component" "" "Pf10248" "8079" "ENSG00000089693" "MLF2" "hsa:8079; Q15773" "" "" "0" "0" "1.049" "0.984" "1.075" "0.984" "0.940" "0.843" "0.830" "0.857" "1.023" "325.9" "341.9" "320.6" "350.4" "320.7" "306.3" "274.7" "270.5" "279.4" "333.4" "" "" "" "" "" "" "" "" "" "" "305.3" "282.9" "297.6" "270.8" "273.4" "292.6" "251.0" "240.2" "279.4" "321.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7098201232450387464" "False" "High" "IsMasterProtein" "Q8N999" "RNA ligase 1 OS=Homo sapiens OX=9606 GN=RLIG1 PE=1 SV=2" "0.000" "False" "8.703" "10" "3" "3" "3" "325" "37.5" "7.06" "9.75" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "" "other molecular function" "Pf17720" "91298" "ENSG00000133641" "RLIG1" "Q569K5; Q6AWA8; Q6PEK5; Q8IYQ5; Q8N999; Q9NT75" "" "" "0" "0" "0.929" "0.972" "1.057" "1.011" "0.986" "1.005" "1.000" "0.889" "0.907" "122.9" "114.2" "119.4" "129.9" "124.2" "121.2" "123.5" "122.9" "109.3" "111.4" "" "" "" "" "" "" "" "" "" "" "115.2" "94.5" "110.9" "100.4" "105.9" "115.8" "112.8" "109.1" "109.3" "107.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4686593457953999194" "False" "High" "IsMasterProtein" "P45985" "Dual specificity mitogen-activated protein kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP2K4 PE=1 SV=1" "0.000" "False" "8.700" "8" "4" "4" "4" "399" "44.3" "8.07" "11.80" "4" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6416" "ENSG00000065559" "MAP2K4" "B2R7N7; B3KYB2; D3DTS5; hsa:6416; P45985; Q5U0B8; Q6FHX4; Q6P9H2; Q6PIE6" "MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; Glioblastoma signaling pathways; TNF-alpha signaling pathway; PDGF pathway; Apoptosis; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Fas ligand pathway and stress induction of heat shock proteins; Photodynamic therapy-induced AP-1 survival signaling; IL6 signaling pathway; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Oxidative damage response; PDGFR-beta pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; GNAQ pathways in port-wine stain; ErbB signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Uptake and function of anthrax toxins; MAP3K8 (TPL2)-dependent MAPK1/3 activation" "35" "0" "0.913" "0.966" "0.971" "0.963" "0.939" "0.927" "0.881" "0.907" "0.907" "718.8" "656.3" "694.6" "697.8" "692.4" "675.0" "666.7" "633.0" "652.1" "652.0" "" "" "" "" "" "" "" "" "" "" "673.6" "543.1" "644.8" "539.4" "590.2" "644.9" "609.2" "562.1" "652.1" "627.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3771039295331557619" "False" "High" "IsMasterProtein" "P12694" "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHA PE=1 SV=2" "0.000" "False" "8.695" "9" "4" "5" "4" "445" "50.4" "8.27" "9.77" "4" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00676" "593" "ENSG00000248098" "BCKDHA" "B4DP47; E7EW46; hsa:593; P12694; Q16034; Q16472" "Lipid metabolism pathway" "Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism" "3" "0" "1.085" "1.028" "1.067" "1.194" "1.110" "1.023" "1.167" "1.055" "1.007" "161.4" "175.0" "165.9" "172.2" "192.6" "179.1" "165.2" "188.4" "170.3" "162.5" "" "" "" "" "" "" "" "" "" "" "151.2" "144.8" "154.0" "133.1" "164.2" "171.1" "150.9" "167.3" "170.3" "156.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8044840362148842225" "False" "High" "IsMasterProtein" "O95376" "E3 ubiquitin-protein ligase ARIH2 OS=Homo sapiens OX=9606 GN=ARIH2 PE=1 SV=1" "0.000" "False" "8.695" "8" "3" "4" "3" "493" "57.8" "5.63" "10.93" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01485, Pf19422" "10425" "ENSG00000177479" "ARIH2" "hsa:10425; O95376; Q9HBZ6; Q9UEM9" "Modulators of TCR signaling and T cell activation" "Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.078" "1.036" "1.237" "1.132" "1.027" "1.105" "1.085" "1.010" "0.961" "295.5" "318.6" "306.1" "365.5" "334.5" "303.4" "326.4" "320.8" "298.5" "284.1" "" "" "" "" "" "" "" "" "" "" "276.9" "263.7" "284.2" "282.5" "285.2" "289.9" "298.3" "284.8" "298.5" "273.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5294747431044223143" "False" "High" "IsMasterProtein" "Q9UBN7" "Histone deacetylase 6 OS=Homo sapiens OX=9606 GN=HDAC6 PE=1 SV=2" "0.000" "False" "8.687" "2" "3" "3" "3" "1215" "131.3" "5.30" "8.63" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00850, Pf02148" "10013" "ENSG00000094631" "HDAC6" "hsa:10013; O94975; Q6NT75; Q7L3E5; Q96CY0; Q9UBN7" "Neural crest differentiation; Ectoderm differentiation; Ectoderm differentiation; Ethanol effects on histone modifications; 7q11.23 copy number variation syndrome; HDAC6 interactions in the central nervous system" "Cilium Assembly; Aggrephagy; Late endosomal microautophagy; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Transcriptional regulation by RUNX2; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Chaperone Mediated Autophagy; HSF1 activation" "17" "0" "1.141" "0.949" "1.083" "0.899" "1.006" "0.935" "0.908" "0.903" "0.956" "186.8" "213.3" "177.2" "202.3" "167.9" "188.0" "174.7" "169.7" "168.6" "178.7" "" "" "" "" "" "" "" "" "" "" "175.1" "176.5" "164.5" "156.4" "143.1" "179.6" "159.7" "150.7" "168.6" "172.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4065169870199249389" "False" "High" "IsMasterProtein" "Q86VP1" "Tax1-binding protein 1 OS=Homo sapiens OX=9606 GN=TAX1BP1 PE=1 SV=2" "0.000" "False" "8.685" "3" "3" "3" "3" "789" "90.8" "5.43" "8.55" "3" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07888, Pf17751, Pf18112" "8887" "ENSG00000106052" "TAX1BP1" "A4D196; B4DKU7; E7ENV2; hsa:8887; O60398; O95770; Q13311; Q86VP1; Q9BQG5; Q9UI88" "" "Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling" "2" "0" "1.030" "1.099" "1.117" "1.074" "1.071" "1.063" "1.089" "1.073" "1.064" "372.2" "383.4" "409.2" "415.8" "399.9" "398.5" "395.5" "405.2" "399.4" "396.0" "" "" "" "" "" "" "" "" "" "" "348.8" "317.3" "379.9" "321.5" "340.9" "380.7" "361.4" "359.8" "399.4" "381.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8855179925451267268" "False" "High" "IsMasterProtein" "Q96F24" "Nuclear receptor-binding factor 2 OS=Homo sapiens OX=9606 GN=NRBF2 PE=1 SV=1" "0.000" "False" "8.679" "9" "3" "3" "3" "287" "32.4" "5.87" "9.42" "3" "other metabolic processes;stress response" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08961, Pf17169" "29982" "ENSG00000148572" "NRBF2" "A6PW36; B4DWS0; hsa:29982; Q86UR2; Q96F24; Q96NP6; Q9H0S9; Q9H2I2" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "" "2" "0" "0.968" "0.980" "0.948" "0.917" "0.928" "0.960" "0.882" "0.956" "0.928" "336.3" "325.4" "329.4" "318.9" "308.5" "312.1" "323.0" "296.5" "321.4" "312.2" "" "" "" "" "" "" "" "" "" "" "315.1" "269.2" "305.9" "246.5" "262.9" "298.2" "295.1" "263.3" "321.4" "300.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1601999827614054718" "False" "High" "IsMasterProtein" "O95067" "G2/mitotic-specific cyclin-B2 OS=Homo sapiens OX=9606 GN=CCNB2 PE=1 SV=1" "0.000" "False" "8.676" "8" "4" "4" "4" "398" "45.3" "8.90" "10.64" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00134, Pf02984" "9133" "ENSG00000157456" "CCNB2" "B3KM93; hsa:9133; O95067; Q6FI99" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; IL-18 signaling pathway; DNA damage response" "The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Initiation of Nuclear Envelope (NE) Reformation; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint" "17" "0" "0.946" "1.000" "0.931" "0.934" "0.960" "0.859" "0.872" "0.890" "0.967" "850.3" "804.6" "850.3" "791.5" "794.0" "816.1" "730.5" "741.5" "757.0" "822.2" "" "" "" "" "" "" "" "" "" "" "796.8" "665.8" "789.4" "611.9" "676.8" "779.7" "667.5" "658.4" "757.0" "791.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3752183774953564252" "False" "High" "IsMasterProtein" "Q8WY36" "HMG box transcription factor BBX OS=Homo sapiens OX=9606 GN=BBX PE=1 SV=1" "0.000" "False" "8.676" "4" "4" "4" "4" "941" "105.1" "8.79" "10.87" "4" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf09667" "56987" "ENSG00000114439" "BBX" "A2RRM7; hsa:56987; Q2TAJ1; Q7L3J8; Q7LBY8; Q8NDB0; Q8WY35; Q8WY36; Q9H0J6" "" "" "0" "0" "0.969" "0.983" "0.985" "0.973" "0.954" "0.941" "0.873" "0.889" "0.974" "634.2" "614.8" "623.6" "624.7" "617.4" "605.3" "597.1" "553.7" "563.9" "617.6" "" "" "" "" "" "" "" "" "" "" "594.3" "508.7" "579.0" "482.9" "526.2" "578.3" "545.6" "491.7" "563.9" "594.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1948620087686216778" "False" "High" "IsMasterProtein" "Q9BQL6" "Fermitin family homolog 1 OS=Homo sapiens OX=9606 GN=FERMT1 PE=1 SV=1" "0.000" "False" "8.674" "5" "3" "4" "3" "677" "77.4" "6.28" "10.03" "3" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf00169, Pf00373, Pf18124" "55612" "ENSG00000101311" "FERMT1" "D3DW10; hsa:55612; Q8IX34; Q8IYH2; Q9BQL6; Q9NWM2; Q9NXQ3" "" "" "0" "0" "0.981" "0.999" "0.972" "0.898" "0.960" "1.015" "0.925" "0.943" "0.961" "314.7" "308.7" "314.5" "305.8" "282.5" "302.2" "319.5" "291.3" "296.9" "302.4" "" "" "" "" "" "" "" "" "" "" "294.9" "255.4" "291.9" "236.4" "240.8" "288.7" "292.0" "258.6" "296.9" "291.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4024286234021820395" "False" "High" "IsMasterProtein" "P78406" "mRNA export factor RAE1 OS=Homo sapiens OX=9606 GN=RAE1 PE=1 SV=1" "0.000" "False" "8.674" "9" "3" "4" "3" "368" "40.9" "7.83" "11.94" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00400" "8480" "ENSG00000101146" "RAE1" "A8K882; hsa:8480; O15306; P78406; Q3SYL7; Q5TCH8; Q6V708; Q9H100; Q9NQM6" "IL-18 signaling pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Transcriptional regulation by small RNAs; Regulation of HSF1-mediated heat shock response; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus" "30" "0" "1.219" "0.990" "1.192" "0.978" "1.167" "1.111" "1.034" "0.961" "1.166" "165.3" "201.6" "163.7" "197.1" "161.7" "192.9" "183.7" "171.0" "158.9" "192.9" "" "" "" "" "" "" "" "" "" "" "154.9" "166.8" "151.9" "152.4" "137.9" "184.3" "167.9" "151.8" "158.9" "185.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7635739719901529146" "False" "High" "IsMasterProtein" "Q8TB03" "Uncharacterized protein CXorf38 OS=Homo sapiens OX=9606 GN=CXorf38 PE=1 SV=1" "0.000" "False" "8.671" "8" "3" "3" "3" "319" "36.6" "6.30" "10.22" "3" "" "" "" "Pf15112" "159013" "ENSG00000185753" "CXorf38" "B3KW28; D3DWB5; hsa:159013; Q5JPF5; Q8N941; Q8TB03" "" "" "0" "0" "0.920" "0.798" "0.991" "0.875" "0.880" "1.077" "0.853" "0.882" "0.928" "197.0" "181.3" "157.2" "195.3" "172.4" "173.4" "212.1" "168.2" "173.8" "182.8" "" "" "" "" "" "" "" "" "" "" "184.6" "150.1" "145.9" "151.0" "146.9" "165.7" "193.8" "149.3" "173.8" "176.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2751742477750142499" "False" "High" "IsMasterProtein" "Q15345" "Leucine-rich repeat-containing protein 41 OS=Homo sapiens OX=9606 GN=LRRC41 PE=1 SV=3" "0.000" "False" "8.670" "4" "3" "3" "3" "812" "88.6" "8.38" "9.47" "3" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "" "10489" "ENSG00000132128" "LRRC41" "A8K5G8; hsa:10489; Q15345; Q3MJ96; Q5TDF5; Q71RA8; Q9BSM0" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; RHOBTB3 ATPase cycle" "3" "0" "0.965" "0.936" "0.892" "0.983" "0.987" "0.881" "0.898" "0.843" "0.959" "304.2" "293.7" "284.7" "271.3" "299.0" "300.2" "268.1" "273.3" "256.5" "291.6" "" "" "" "" "" "" "" "" "" "" "285.0" "243.0" "264.3" "209.8" "254.8" "286.8" "245.0" "242.6" "256.5" "280.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2020319621841403457" "False" "High" "IsMasterProtein" "P07741" "Adenine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=APRT PE=1 SV=2" "0.000" "False" "8.668" "16" "3" "5" "3" "180" "19.6" "6.02" "15.52" "3" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00156" "353" "ENSG00000198931" "APRT" "G5E9J2; hsa:353; P07741; Q3KP55; Q68DF9" "" "Neutrophil degranulation; Purine salvage; Defective APRT disrupts adenine salvage" "3" "0" "0.925" "0.948" "0.884" "0.812" "0.934" "0.858" "0.937" "0.871" "0.869" "919.6" "850.7" "871.8" "812.5" "746.4" "859.3" "789.4" "862.0" "800.9" "799.4" "" "" "" "" "" "" "" "" "" "" "861.6" "703.9" "809.3" "628.1" "636.2" "821.0" "721.3" "765.4" "800.9" "769.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5772748486031489240" "False" "High" "IsMasterProtein" "Q9Y3R5" "Protein dopey-2 OS=Homo sapiens OX=9606 GN=DOP1B PE=1 SV=5" "0.000" "False" "8.664" "2" "4" "4" "4" "2298" "258.1" "6.29" "8.12" "4" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "" "Pf04118" "9980" "ENSG00000142197" "DOP1B" "D3DSG5; hsa:9980; Q6PJQ7; Q9UEZ3; Q9Y3R5" "" "" "0" "0" "1.025" "0.900" "1.200" "1.106" "1.099" "1.098" "1.118" "1.078" "1.100" "181.5" "186.1" "163.3" "217.8" "200.7" "199.5" "199.2" "202.9" "195.6" "199.5" "" "" "" "" "" "" "" "" "" "" "170.0" "154.0" "151.6" "168.4" "171.1" "190.6" "182.0" "180.2" "195.6" "192.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8588470506095453677" "False" "High" "IsMasterProtein" "P21912" "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHB PE=1 SV=3" "0.000" "False" "8.662" "12" "4" "4" "4" "280" "31.6" "8.76" "12.79" "4" "other metabolic processes" "plasma membrane;other membranes;mitochondrion;nucleus" "other molecular function" "Pf13085, Pf13534" "6390" "ENSG00000117118" "SDHB" "B2R545; hsa:6390; P21912; Q0QEY7; Q9NQ12" "Electron transport chain: OXPHOS system in mitochondria; Metabolic reprogramming in colon cancer; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; TCA cycle (aka Krebs or citric acid cycle)" "Respiratory electron transport; Citric acid cycle (TCA cycle)" "7" "0" "1.074" "1.041" "1.064" "1.088" "1.043" "0.969" "1.095" "1.234" "1.096" "248.4" "266.7" "258.4" "264.2" "270.2" "259.1" "240.6" "271.8" "306.6" "272.3" "" "" "" "" "" "" "" "" "" "" "232.7" "220.7" "239.9" "204.3" "230.3" "247.6" "219.8" "241.4" "306.6" "262.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-348929784632102448" "False" "High" "IsMasterProtein" "O75306" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS2 PE=1 SV=2" "0.000" "False" "8.659" "6" "3" "3" "3" "463" "52.5" "7.55" "8.41" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;mitochondrion;nucleus" "transporter activity;other molecular function" "Pf00346" "4720" "ENSG00000158864" "NDUFS2" "D3DVG7; hsa:4720; J3KPM7; O75306; Q5VTW0; Q969P3; Q9UEV3" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "1.087" "1.112" "1.125" "1.115" "1.179" "1.054" "1.015" "1.049" "1.157" "260.9" "283.7" "290.3" "293.6" "290.9" "307.6" "275.2" "264.8" "273.7" "302.0" "" "" "" "" "" "" "" "" "" "" "244.5" "234.7" "269.5" "227.0" "247.9" "293.9" "251.4" "235.1" "273.7" "290.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5516289566189376071" "False" "High" "IsMasterProtein" "Q13084" "Large ribosomal subunit protein bL28m OS=Homo sapiens OX=9606 GN=MRPL28 PE=1 SV=4" "0.000" "False" "8.654" "13" "3" "4" "3" "256" "30.1" "8.29" "6.30" "3" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "other molecular function" "Pf00830" "10573" "ENSG00000086504" "MRPL28" "B2RCM4; D3DU46; hsa:10573; Q13084; Q4TT39; Q96S26; Q9BQD8; Q9BR04" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.184" "1.144" "1.041" "1.118" "1.133" "1.117" "0.979" "1.111" "1.170" "84.7" "100.2" "96.9" "88.2" "94.7" "96.0" "94.6" "82.9" "94.1" "99.1" "" "" "" "" "" "" "" "" "" "" "79.4" "83.0" "90.0" "68.2" "80.7" "91.7" "86.4" "73.6" "94.1" "95.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1553540605597619179" "False" "High" "IsMasterProtein" "P51965" "Ubiquitin-conjugating enzyme E2 E1 OS=Homo sapiens OX=9606 GN=UBE2E1 PE=1 SV=1" "0.000" "False" "8.650" "17" "3" "5" "2" "193" "21.4" "8.53" "16.54" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7324" "ENSG00000170142" "UBE2E1" "B2RBX4; C9J8K2; hsa:7324; K4DI90; P51965" "Photodynamic therapy-induced unfolded protein response; 7q11.23 copy number variation syndrome" "Separation of Sister Chromatids; Assembly of the pre-replicative complex; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; ISG15 antiviral mechanism; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "23" "0" "0.967" "0.979" "0.850" "0.881" "0.879" "0.885" "0.972" "0.890" "0.932" "981.9" "949.3" "961.1" "834.4" "864.7" "862.8" "868.8" "954.4" "874.0" "915.4" "" "" "" "" "" "" "" "" "" "" "920.0" "785.6" "892.3" "645.0" "737.1" "824.3" "793.9" "847.4" "874.0" "881.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9146953398004624321" "False" "High" "IsMasterProtein" "Q00613" "Heat shock factor protein 1 OS=Homo sapiens OX=9606 GN=HSF1 PE=1 SV=1" "0.000" "False" "8.643" "5" "3" "5" "3" "529" "57.2" "5.19" "15.44" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00447, Pf06546" "3297" "ENSG00000185122; ENSG00000284774" "HSF1" "A8K4L0; A8MW26; hsa:3297; Q00613; Q53XT4" "10q11.21q11.23 copy number variation syndrome; HDAC6 interactions in the central nervous system" "Regulation of HSF1-mediated heat shock response; Attenuation phase; Aggrephagy; HSF1 activation" "7" "0" "0.958" "0.937" "0.926" "0.983" "0.997" "0.904" "0.924" "0.955" "1.030" "419.6" "401.8" "393.0" "388.5" "412.3" "418.5" "379.5" "387.8" "400.7" "432.2" "" "" "" "" "" "" "" "" "" "" "393.1" "332.5" "364.9" "300.4" "351.5" "399.8" "346.8" "344.3" "400.7" "416.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5628662921146722487" "False" "High" "IsMasterProtein" "Q9UL18" "Protein argonaute-1 OS=Homo sapiens OX=9606 GN=AGO1 PE=1 SV=3" "0.000" "False" "8.641" "4" "3" "5" "1" "857" "97.2" "9.16" "10.22" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02170, Pf02171, Pf08699, Pf16486, Pf16487, Pf16488" "26523" "ENSG00000092847" "AGO1" "hsa:26523; Q5TA57; Q6P4S0; Q9UL18" "Modulators of TCR signaling and T cell activation" "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; MAPK6/MAPK4 signaling; Transcriptional regulation by small RNAs; Oxidative Stress Induced Senescence; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Ca2+ pathway; Regulation of MECP2 expression and activity; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis; Nuclear events stimulated by ALK signaling in cancer; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "23" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2381350149897154971" "False" "High" "IsMasterProtein" "P51572" "B-cell receptor-associated protein 31 OS=Homo sapiens OX=9606 GN=BCAP31 PE=1 SV=3" "0.000" "False" "8.640" "13" "4" "4" "4" "246" "28.0" "8.44" "11.88" "4" "stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05529, Pf18035" "10134" "ENSG00000185825" "BCAP31" "B3KQ79; D3DWV5; hsa:10134; P51572; Q13836; Q96CF0" "" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC; RSV-host interactions; RHOA GTPase cycle; Apoptotic cleavage of cellular proteins" "5" "0" "0.898" "0.986" "1.164" "1.171" "1.203" "2.281" "2.276" "1.933" "1.452" "750.3" "673.7" "739.8" "873.1" "878.3" "902.7" "1711.4" "1707.8" "1450.5" "1089.1" "" "" "" "" "" "" "" "" "" "" "703.0" "557.5" "686.8" "674.9" "748.6" "862.4" "1563.7" "1516.3" "1450.5" "1048.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3196663768808374141" "False" "High" "IsMasterProtein" "Q9UBP6" "tRNA (guanine-N(7)-)-methyltransferase OS=Homo sapiens OX=9606 GN=METTL1 PE=1 SV=1" "0.000" "False" "8.633" "14" "3" "4" "3" "276" "31.5" "7.64" "8.93" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02390" "4234" "ENSG00000037897" "METTL1" "B2RBX1; H7BXF2; hsa:4234; Q14105; Q53FS9; Q9UBP6" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.176" "1.170" "1.146" "1.258" "1.215" "1.205" "1.205" "1.298" "1.168" "215.2" "253.1" "251.9" "246.7" "270.8" "261.4" "259.4" "259.3" "279.5" "251.3" "" "" "" "" "" "" "" "" "" "" "201.7" "209.4" "233.9" "190.7" "230.8" "249.8" "237.0" "230.2" "279.5" "242.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2311027039317612116" "False" "High" "IsMasterProtein" "Q9Y3B8" "Oligoribonuclease, mitochondrial OS=Homo sapiens OX=9606 GN=REXO2 PE=1 SV=3" "0.000" "False" "8.630" "14" "3" "4" "3" "237" "26.8" "6.87" "11.29" "3" "DNA metabolism;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00929" "25996" "ENSG00000076043" "REXO2" "B2R532; hsa:25996; Q32Q18; Q53FT1; Q6FIC6; Q9UFY7; Q9Y3B8" "" "Mitochondrial RNA degradation" "1" "0" "0.998" "0.901" "0.938" "0.962" "0.941" "0.875" "0.971" "0.928" "0.928" "1170.0" "1168.2" "1053.6" "1097.7" "1126.1" "1100.5" "1024.3" "1136.5" "1086.2" "1085.5" "" "" "" "" "" "" "" "" "" "" "1096.3" "966.7" "978.1" "848.6" "959.9" "1051.5" "935.9" "1009.1" "1086.2" "1045.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8334369527451810461" "False" "High" "IsMasterProtein" "Q8NF64" "Zinc finger MIZ domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZMIZ2 PE=1 SV=2" "0.000" "False" "8.625" "4" "4" "4" "1" "920" "96.5" "7.12" "10.72" "4" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf02891" "83637" "ENSG00000122515" "ZMIZ2" "A4D2K7; D3DVL1; hsa:83637; O94790; Q0VGB4; Q659A8; Q6JKL5; Q8NF64; Q8WTX8; Q96Q01; Q9BQH7" "" "" "0" "0" "0.962" "0.941" "0.935" "1.034" "0.939" "0.805" "0.951" "0.952" "1.002" "272.4" "262.0" "256.2" "254.6" "281.6" "255.7" "219.1" "259.1" "259.2" "272.8" "" "" "" "" "" "" "" "" "" "" "255.2" "216.8" "237.9" "196.8" "240.0" "244.3" "200.2" "230.1" "259.2" "262.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-948672987785726372" "False" "High" "IsMasterProtein" "Q9BT25" "HAUS augmin-like complex subunit 8 OS=Homo sapiens OX=9606 GN=HAUS8 PE=1 SV=3" "0.000" "False" "8.609" "7" "3" "4" "3" "410" "44.8" "7.06" "13.04" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "" "93323" "ENSG00000131351" "HAUS8" "B4DJA7; C9JBZ4; hsa:93323; Q49AC4; Q86WF0; Q96FX3; Q9BT25" "" "Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "1.154" "1.000" "1.164" "0.967" "0.951" "0.841" "0.821" "0.859" "1.008" "232.6" "268.3" "232.6" "270.7" "224.9" "221.3" "195.5" "191.1" "199.7" "234.4" "" "" "" "" "" "" "" "" "" "" "217.9" "222.0" "216.0" "209.3" "191.7" "211.4" "178.7" "169.6" "199.7" "225.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8051060092972963537" "False" "High" "IsMasterProtein" "P05412" "Transcription factor Jun OS=Homo sapiens OX=9606 GN=JUN PE=1 SV=2" "0.000" "False" "8.609" "9" "3" "3" "1" "331" "35.7" "8.76" "10.20" "3" "stress response;signal transduction;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00170, Pf03957" "3725" "ENSG00000177606" "JUN" "hsa:3725; P05412; Q6FHM7; Q96G93" "IL-5 signaling pathway; Androgen receptor signaling pathway; Physiological and pathological hypertrophy of the heart; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; ATM signaling pathway; Apoptosis; Polycystic kidney disease pathway; Selenium metabolism and selenoproteins; IL-3 signaling pathway; Aryl hydrocarbon receptor pathway; Glucocorticoid receptor pathway; Estrogen receptor pathway; Nuclear receptors meta-pathway; Myometrial relaxation and contraction pathways; Focal adhesion; Hepatocyte growth factor receptor signaling; Fas ligand pathway and stress induction of heat shock proteins; Copper homeostasis; MFAP5-mediated ovarian cancer cell motility and invasiveness; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; PDGFR-beta pathway; Wnt signaling pathway and pluripotency; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Signal transduction through IL1R; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Neural crest cell migration during development; Neural crest cell migration in cancer; Cancer immunotherapy by PD-1 blockade; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Host-pathogen interaction of human coronaviruses - MAPK signaling; Host-pathogen interaction of human coronaviruses - interferon induction; IL-2 signaling pathway; 3q29 copy number variation syndrome; Neuroinflammation; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; Th17 cell differentiation pathway; Inflammatory bowel disease signaling; 2q37 copy number variation syndrome; TROP2 regulatory signaling; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; Osteoarthritic chondrocyte hypertrophy; 5q35 copy number variation; TGF-beta receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response (only ATM dependent); Estrogen signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated MAPK activation; MAPK6/MAPK4 signaling; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; TP53 Regulates Transcription of DNA Repair Genes; Signaling by ALK fusions and activated point mutants; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); WNT5:FZD7-mediated leishmania damping; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Activation of the AP-1 family of transcription factors" "98" "0" "0.972" "1.003" "1.067" "1.185" "0.916" "1.121" "1.093" "1.024" "1.067" "176.4" "171.5" "177.0" "188.2" "209.0" "161.6" "197.8" "192.8" "180.7" "188.3" "" "" "" "" "" "" "" "" "" "" "165.3" "141.9" "164.3" "145.5" "178.1" "154.4" "180.7" "171.2" "180.7" "181.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9046713427756662077" "False" "High" "IsMasterProtein" "Q05209" "Tyrosine-protein phosphatase non-receptor type 12 OS=Homo sapiens OX=9606 GN=PTPN12 PE=1 SV=3" "0.000" "False" "8.604" "4" "4" "5" "4" "780" "88.1" "5.62" "10.69" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00102" "5782" "ENSG00000127947" "PTPN12" "A4D1C5; B4DKY2; E9PBR5; E9PEH9; hsa:5782; Q05209; Q16130; Q59FD6; Q75MN8; Q86XU4" "EGF/EGFR signaling pathway" "Signaling by PDGF; SHC1 events in ERBB2 signaling; Downregulation of ERBB2 signaling; EGFR downregulation; Interleukin-37 signaling; Constitutive Signaling by Overexpressed ERBB2" "7" "0" "0.802" "0.917" "0.894" "0.875" "0.878" "1.317" "0.979" "0.940" "0.966" "174.7" "140.1" "160.3" "156.2" "152.8" "153.4" "230.2" "171.0" "164.2" "168.7" "" "" "" "" "" "" "" "" "" "" "163.7" "115.9" "148.8" "120.8" "130.2" "146.6" "210.3" "151.8" "164.2" "162.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5702774175857427246" "False" "High" "IsMasterProtein" "Q02078" "Myocyte-specific enhancer factor 2A OS=Homo sapiens OX=9606 GN=MEF2A PE=1 SV=1" "0.000" "False" "8.603" "8" "3" "4" "1" "507" "54.8" "7.91" "7.85" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4205" "ENSG00000068305" "MEF2A" "B4DFQ7; F6XG23; hsa:4205; O43814; Q02078; Q14223; Q14224; Q59GX4; Q7Z6C9; Q96D14" "Energy metabolism; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; TGF-beta signaling pathway; EGF/EGFR signaling pathway; IL-18 signaling pathway; 2q37 copy number variation syndrome" "Myogenesis; ERK/MAPK targets" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4637087941136759499" "False" "High" "IsMasterProtein" "O15126" "Secretory carrier-associated membrane protein 1 OS=Homo sapiens OX=9606 GN=SCAMP1 PE=1 SV=2" "0.000" "False" "8.592" "8" "3" "6" "3" "338" "37.9" "7.42" "15.89" "3" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04144" "9522" "ENSG00000085365" "SCAMP1" "hsa:9522; O15126; O43587; Q6FG23; Q96BX1; Q96QK5" "" "Neutrophil degranulation" "1" "0" "0.910" "0.901" "0.974" "0.943" "0.913" "0.835" "0.910" "0.907" "0.900" "126.5" "115.1" "114.0" "123.2" "119.2" "115.6" "105.6" "115.1" "114.8" "113.9" "" "" "" "" "" "" "" "" "" "" "118.5" "95.3" "105.9" "95.3" "101.6" "110.4" "96.5" "102.2" "114.8" "109.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3037258603534985886" "False" "High" "IsMasterProtein" "Q12974" "Protein tyrosine phosphatase type IVA 2 OS=Homo sapiens OX=9606 GN=PTP4A2 PE=1 SV=1" "0.000" "False" "8.585" "15" "3" "3" "3" "167" "19.1" "8.37" "10.07" "3" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00102" "8073" "ENSG00000184007" "PTP4A2" "A8K9I8; B4DM39; D3DPP0; E9PGJ6; hsa:8073; O00649; Q12974; Q15197; Q15259; Q15260; Q15261; R4GN50" "" "RAB geranylgeranylation" "1" "0" "0.974" "0.899" "0.959" "0.987" "1.080" "0.819" "0.885" "1.015" "1.000" "131.8" "128.4" "118.5" "126.4" "130.1" "142.3" "107.9" "116.6" "133.7" "131.7" "" "" "" "" "" "" "" "" "" "" "123.5" "106.3" "110.0" "97.7" "110.9" "136.0" "98.6" "103.6" "133.7" "126.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9128432651374987381" "False" "High" "IsMasterProtein" "Q9NNW5" "tRNA (34-2'-O)-methyltransferase regulator WDR6 OS=Homo sapiens OX=9606 GN=WDR6 PE=1 SV=1" "0.000" "False" "8.584" "3" "3" "4" "3" "1121" "121.6" "6.87" "14.14" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf00400" "11180" "ENSG00000178252" "WDR6" "B4DHK2; hsa:11180; Q3MIT1; Q9NNW5; Q9UF63" "" "RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle" "5" "0" "0.876" "0.900" "1.055" "0.962" "0.876" "0.969" "0.818" "0.740" "0.934" "126.9" "111.2" "114.2" "133.9" "122.1" "111.1" "122.9" "103.8" "93.9" "118.5" "" "" "" "" "" "" "" "" "" "" "118.9" "92.0" "106.0" "103.5" "104.1" "106.1" "112.3" "92.2" "93.9" "114.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3643109724268830478" "False" "High" "IsMasterProtein" "Q8WUH1" "Protein Churchill OS=Homo sapiens OX=9606 GN=CHURC1 PE=1 SV=3" "0.000" "False" "8.581" "33" "3" "3" "3" "112" "12.9" "4.84" "9.42" "3" "signal transduction;other biological processes" "" "other molecular function" "Pf06573" "91612" "ENSG00000258289" "CHURC1" "A0A0C4DGJ7; B3KQ81; G3V1X3; G3V214; hsa:91612; Q8WUH1; Q9H3K7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6087199310060456450" "False" "High" "IsMasterProtein" "Q9UI30" "Multifunctional methyltransferase subunit TRM112-like protein OS=Homo sapiens OX=9606 GN=TRMT112 PE=1 SV=1" "0.000" "False" "8.579" "28" "3" "3" "3" "125" "14.2" "5.26" "11.91" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03966" "51504" "ENSG00000173113" "TRMT112" "B2R539; hsa:51504; J3KNG5; Q3MHC7; Q8N2Z4; Q9UI30" "" "Methylation; rRNA modification in the nucleus and cytosol; tRNA modification in the nucleus and cytosol; Eukaryotic Translation Termination" "4" "0" "1.074" "0.991" "1.053" "1.033" "1.060" "0.938" "0.993" "1.037" "0.996" "445.7" "478.6" "441.9" "469.4" "460.3" "472.5" "418.2" "442.5" "462.1" "443.9" "" "" "" "" "" "" "" "" "" "" "417.7" "396.0" "410.2" "362.8" "392.4" "451.4" "382.2" "392.9" "462.1" "427.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4761760755167772661" "False" "High" "IsMasterProtein" "Q9GZR2" "RNA exonuclease 4 OS=Homo sapiens OX=9606 GN=REXO4 PE=1 SV=2" "0.000" "False" "8.577" "8" "4" "5" "4" "422" "46.6" "9.77" "9.92" "4" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00929" "57109" "ENSG00000148300; ENSG00000280706" "REXO4" "B2RAT2; hsa:57109; Q5T8S4; Q5T8S5; Q5T8S6; Q9GZR2; Q9GZW3" "" "" "0" "0" "1.051" "0.988" "1.099" "1.136" "1.158" "1.263" "1.233" "1.160" "1.165" "196.2" "206.3" "193.9" "215.6" "222.9" "227.2" "247.8" "241.8" "227.5" "228.6" "" "" "" "" "" "" "" "" "" "" "183.8" "170.7" "180.0" "166.7" "190.0" "217.0" "226.4" "214.7" "227.5" "220.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "809495191273134722" "False" "High" "IsMasterProtein" "P42356" "Phosphatidylinositol 4-kinase alpha OS=Homo sapiens OX=9606 GN=PI4KA PE=1 SV=4" "0.000" "False" "8.568" "1" "3" "3" "3" "2102" "236.7" "7.06" "7.37" "3" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf19274" "5297" "ENSG00000241973" "PI4KA" "hsa:5297; P42356; Q7Z625; Q9UPG2" "Ectoderm differentiation; 22q11.2 copy number variation syndrome" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the ER membrane" "4" "0" "0.921" "0.926" "1.035" "1.004" "0.986" "0.946" "0.937" "0.864" "0.927" "189.0" "174.1" "175.0" "195.6" "189.8" "186.3" "178.8" "177.1" "163.3" "175.2" "" "" "" "" "" "" "" "" "" "" "177.1" "144.0" "162.5" "151.2" "161.8" "178.0" "163.3" "157.2" "163.3" "168.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7682312476163043373" "False" "High" "IsMasterProtein" "P82914" "Small ribosomal subunit protein uS15m OS=Homo sapiens OX=9606 GN=MRPS15 PE=1 SV=1" "0.000" "False" "8.558" "12" "4" "4" "4" "257" "29.8" "10.48" "8.65" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00312" "64960" "ENSG00000116898" "MRPS15" "B2RD82; hsa:64960; P82914; Q9H2K1" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.045" "1.162" "1.010" "1.014" "0.987" "1.035" "0.883" "0.994" "1.126" "339.5" "354.9" "394.7" "342.8" "344.2" "335.0" "351.3" "299.8" "337.6" "382.3" "" "" "" "" "" "" "" "" "" "" "318.1" "293.7" "366.4" "265.0" "293.4" "320.1" "321.0" "266.2" "337.6" "368.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "120688063892906197" "False" "High" "IsMasterProtein" "Q6P4R8" "Nuclear factor related to kappa-B-binding protein OS=Homo sapiens OX=9606 GN=NFRKB PE=1 SV=2" "0.000" "False" "8.551" "2" "3" "3" "3" "1299" "138.9" "9.25" "9.12" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf14465" "4798" "ENSG00000170322" "NFRKB" "hsa:4798; Q12869; Q15312; Q6P4R8; Q9H048" "Overview of nanoparticle effects" "UCH proteinases; DNA Damage Recognition in GG-NER" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6421392599925785436" "False" "High" "IsMasterProtein" "Q9HD15" "Steroid receptor RNA activator 1 OS=Homo sapiens OX=9606 GN=SRA1 PE=1 SV=2" "0.000" "False" "8.543" "15" "3" "4" "3" "224" "24.4" "7.50" "11.81" "3" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07304" "10011" "ENSG00000213523" "SRA1" "hsa:10011; Q6NVU9; Q8IXM1; Q9HD13; Q9HD14; Q9HD15" "" "" "0" "0" "0.985" "0.940" "0.986" "0.992" "1.039" "0.970" "1.008" "0.909" "0.962" "942.6" "928.4" "886.2" "929.2" "935.3" "979.1" "914.2" "950.5" "856.4" "906.5" "" "" "" "" "" "" "" "" "" "" "883.2" "768.2" "822.8" "718.3" "797.2" "935.5" "835.4" "843.9" "856.4" "872.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6107269265140402008" "False" "High" "IsMasterProtein" "P10109" "Adrenodoxin, mitochondrial OS=Homo sapiens OX=9606 GN=FDX1 PE=1 SV=1" "0.000" "False" "8.528" "13" "3" "3" "3" "184" "19.4" "5.83" "9.82" "3" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00111" "2230" "ENSG00000137714" "FDX1" "B0YJ14; hsa:2230; P10109; Q53YD6" "Iron-sulfur cluster biogenesis" "Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin" "6" "0" "1.050" "0.942" "0.850" "1.019" "1.078" "0.955" "1.012" "0.928" "0.980" "578.3" "607.1" "544.9" "491.8" "589.3" "623.3" "552.5" "585.1" "536.6" "566.8" "" "" "" "" "" "" "" "" "" "" "541.9" "502.4" "505.8" "380.2" "502.3" "595.5" "504.8" "519.5" "536.6" "545.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2594177095458516104" "False" "High" "IsMasterProtein" "P24386" "Rab proteins geranylgeranyltransferase component A 1 OS=Homo sapiens OX=9606 GN=CHM PE=1 SV=3" "0.000" "False" "8.523" "5" "4" "5" "2" "653" "73.4" "4.75" "10.97" "4" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "1121" "ENSG00000188419" "CHM" "A1L4D2; hsa:1121; O43732; P24386" "" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "3" "1" "1.138" "1.091" "1.173" "1.088" "1.134" "1.070" "1.045" "1.138" "1.109" "211.9" "241.2" "231.1" "248.5" "230.5" "240.1" "226.6" "221.5" "241.0" "234.8" "" "" "" "" "" "" "" "" "" "" "198.5" "199.6" "214.5" "192.1" "196.4" "229.4" "207.1" "196.6" "241.0" "226.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6376451565471680516" "False" "High" "IsMasterProtein" "Q6P4I2" "WD repeat-containing protein 73 OS=Homo sapiens OX=9606 GN=WDR73 PE=1 SV=1" "0.000" "False" "8.499" "8" "3" "3" "3" "378" "41.7" "5.78" "8.42" "3" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "" "" "84942" "ENSG00000177082; ENSG00000291629" "WDR73" "hsa:84942; Q6P4I2; Q96JZ1; Q9P0B7" "Nephrotic syndrome; 15q25 copy number variation" "" "2" "0" "1.024" "1.057" "1.139" "1.055" "1.041" "0.996" "1.041" "1.032" "1.042" "316.6" "324.4" "334.5" "360.6" "334.0" "329.6" "315.4" "329.7" "326.6" "330.0" "" "" "" "" "" "" "" "" "" "" "296.7" "268.4" "310.6" "278.8" "284.7" "314.9" "288.2" "292.8" "326.6" "317.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-507762156530799771" "False" "High" "IsMasterProtein" "O43670" "BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1" "0.000" "False" "8.494" "7" "3" "6" "3" "478" "50.7" "9.10" "17.55" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "" "7756" "ENSG00000010244" "ZNF207" "A8K6Y6; E1P660; E1P661; E1P662; hsa:7756; O43670; Q53XS9; Q96HW5; Q9BUQ7" "" "" "0" "0" "1.001" "1.101" "1.050" "1.048" "1.085" "1.075" "1.151" "1.095" "1.046" "778.8" "779.3" "857.6" "817.5" "816.4" "844.8" "837.2" "896.3" "853.0" "814.7" "" "" "" "" "" "" "" "" "" "" "729.8" "644.8" "796.1" "632.0" "695.9" "807.2" "765.0" "795.8" "853.0" "784.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6687881647514235914" "False" "High" "IsMasterProtein" "Q147X3" "N-alpha-acetyltransferase 30 OS=Homo sapiens OX=9606 GN=NAA30 PE=1 SV=1" "0.000" "False" "8.491" "10" "3" "5" "3" "362" "39.3" "5.52" "15.85" "3" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "122830" "ENSG00000139977" "NAA30" "hsa:122830; Q0IIN2; Q147X3" "Metapathway biotransformation Phase I and II" "Retrograde transport at the Trans-Golgi-Network" "2" "0" "0.943" "1.018" "1.058" "1.014" "1.081" "0.995" "1.009" "1.008" "1.065" "391.9" "369.5" "398.9" "414.5" "397.2" "423.8" "390.0" "395.6" "395.0" "417.2" "" "" "" "" "" "" "" "" "" "" "367.2" "305.8" "370.3" "320.4" "338.6" "404.9" "356.4" "351.2" "395.0" "401.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5153257351632709387" "False" "High" "IsMasterProtein" "P26374" "Rab proteins geranylgeranyltransferase component A 2 OS=Homo sapiens OX=9606 GN=CHML PE=1 SV=2" "0.000" "False" "8.485" "5" "4" "5" "2" "656" "74.0" "4.93" "10.81" "4" "protein metabolism;other metabolic processes;transport;signal transduction" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "1122" "ENSG00000203668" "CHML" "B2RAB9; hsa:1122; P26374; Q17RE0; Q9H1Y4" "" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation" "2" "0" "1.068" "1.234" "1.334" "1.290" "1.128" "1.268" "1.190" "1.186" "1.156" "101.6" "108.5" "125.4" "135.6" "131.0" "114.6" "128.8" "120.9" "120.6" "117.4" "" "" "" "" "" "" "" "" "" "" "95.2" "89.8" "116.4" "104.8" "111.7" "109.5" "117.7" "107.3" "120.6" "113.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4597913287802266182" "False" "High" "IsMasterProtein" "O60921" "Checkpoint protein HUS1 OS=Homo sapiens OX=9606 GN=HUS1 PE=1 SV=1" "0.000" "False" "8.483" "12" "3" "3" "3" "280" "31.7" "6.84" "9.43" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04005" "3364" "ENSG00000136273" "HUS1" "B4DFI9; hsa:3364; O60921" "ATR signaling" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "8" "0" "0.909" "0.993" "1.138" "1.155" "1.051" "1.321" "1.235" "1.433" "1.066" "148.5" "135.0" "147.4" "168.9" "171.5" "156.0" "196.1" "183.4" "212.8" "158.3" "" "" "" "" "" "" "" "" "" "" "139.1" "111.7" "136.8" "130.6" "146.2" "149.1" "179.2" "162.9" "212.8" "152.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7557449725087676483" "False" "High" "IsMasterProtein" "Q3MIT2" "tRNA pseudouridine synthase Pus10 OS=Homo sapiens OX=9606 GN=PUS10 PE=1 SV=1" "0.000" "False" "8.480" "5" "3" "3" "3" "529" "60.2" "6.54" "9.40" "3" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf21237, Pf21238" "150962" "ENSG00000162927" "PUS10" "hsa:150962; Q3MIT2; Q5JPJ5; Q96MI8" "" "" "0" "0" "1.032" "1.029" "1.010" "1.066" "1.044" "1.013" "0.969" "1.021" "1.052" "399.8" "412.7" "411.4" "403.6" "426.2" "417.4" "404.9" "387.4" "408.0" "420.4" "" "" "" "" "" "" "" "" "" "" "374.6" "341.5" "382.0" "312.0" "363.3" "398.7" "370.0" "343.9" "408.0" "404.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3414895648230328268" "False" "High" "IsMasterProtein" "Q92667" "A-kinase anchor protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=AKAP1 PE=1 SV=1" "0.000" "False" "8.478" "3" "3" "5" "3" "903" "97.3" "4.94" "12.21" "3" "stress response;other biological processes" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf00013, Pf00567" "8165" "ENSG00000121057" "AKAP1" "A8K8Q1; D3DTZ0; hsa:8165; Q13320; Q92667; Q9BW14" "G protein signaling pathways" "Factors involved in megakaryocyte development and platelet production; Mitochondrial calcium ion transport" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7904410846819458044" "False" "High" "IsMasterProtein" "Q92796" "Disks large homolog 3 OS=Homo sapiens OX=9606 GN=DLG3 PE=1 SV=2" "0.000" "False" "8.475" "4" "3" "3" "3" "817" "90.3" "7.03" "9.82" "3" "cell adhesion;cell-cell signaling;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00018, Pf00595, Pf00625, Pf10600" "1741" "ENSG00000082458" "DLG3" "B4E0H1; D3DVU5; hsa:1741; Q5JUW6; Q5JUW7; Q92796; Q9ULI8" "Cell lineage map for neuronal differentiation" "Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Neurexins and neuroligins; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; NrCAM interactions; Activation of Ca-permeable Kainate Receptor" "11" "0" "0.956" "1.102" "0.952" "1.072" "1.024" "0.986" "0.945" "1.022" "1.122" "301.5" "288.3" "332.2" "286.9" "323.4" "308.8" "297.4" "284.9" "308.1" "338.5" "" "" "" "" "" "" "" "" "" "" "282.5" "238.6" "308.4" "221.8" "275.6" "295.1" "271.7" "253.0" "308.1" "325.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8070932965104358622" "False" "High" "IsMasterProtein" "Q86YS7" "C2 domain-containing protein 5 OS=Homo sapiens OX=9606 GN=C2CD5 PE=1 SV=1" "0.000" "False" "8.468" "3" "3" "3" "3" "1000" "110.4" "5.69" "9.87" "3" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00168" "9847" "ENSG00000111731" "C2CD5" "B4DJ03; B4DRN7; B7ZLL0; F5H2A1; F5H5R1; hsa:9847; O60280; Q17RY7; Q7Z619; Q86SU3; Q86YS7" "" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "1" "0" "1.184" "1.285" "1.454" "1.364" "1.164" "1.658" "1.436" "2.300" "1.291" "60.9" "72.1" "78.3" "88.5" "83.1" "70.9" "101.0" "87.5" "140.1" "78.6" "" "" "" "" "" "" "" "" "" "" "57.1" "59.7" "72.7" "68.4" "70.8" "67.7" "92.3" "77.6" "140.1" "75.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1197629715335020775" "False" "High" "IsMasterProtein" "Q02535" "DNA-binding protein inhibitor ID-3 OS=Homo sapiens OX=9606 GN=ID3 PE=1 SV=2" "0.000" "False" "8.467" "27" "3" "5" "3" "119" "13.0" "5.83" "14.30" "3" "developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00010" "3399" "ENSG00000117318; ENSG00000283060" "ID3" "A8K1T8; hsa:3399; O75641; Q02535" "Adipogenesis; Orexin receptor pathway; ID signaling pathway" "NGF-stimulated transcription" "4" "0" "1.056" "1.006" "1.122" "1.091" "1.072" "1.049" "0.979" "0.961" "1.058" "343.7" "363.0" "345.6" "385.7" "374.9" "368.4" "360.7" "336.3" "330.2" "363.7" "" "" "" "" "" "" "" "" "" "" "322.0" "300.4" "320.8" "298.2" "319.5" "352.0" "329.6" "298.6" "330.2" "350.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3559430331434459476" "False" "High" "IsMasterProtein" "O95630" "STAM-binding protein OS=Homo sapiens OX=9606 GN=STAMBP PE=1 SV=1" "0.000" "False" "8.467" "8" "3" "3" "3" "424" "48.0" "6.29" "9.02" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf01398, Pf08969" "10617" "ENSG00000124356" "STAMBP" "B5M0B6; D6W5H7; hsa:10617; O95630; Q3MJE7" "EGF/EGFR signaling pathway" "Metalloprotease DUBs" "2" "0" "1.033" "0.972" "1.053" "1.016" "1.021" "0.969" "1.014" "1.061" "1.011" "418.5" "432.4" "406.7" "440.9" "425.4" "427.2" "405.5" "424.3" "443.9" "423.1" "" "" "" "" "" "" "" "" "" "" "392.1" "357.8" "377.6" "340.8" "362.6" "408.2" "370.5" "376.7" "443.9" "407.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1354238916064112101" "False" "High" "IsMasterProtein" "Q5T6V5" "Queuosine 5'-phosphate N-glycosylase/hydrolase OS=Homo sapiens OX=9606 GN=QNG1 PE=1 SV=1" "0.000" "False" "8.452" "9" "4" "4" "4" "341" "39.0" "5.88" "9.94" "4" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf10343" "84267" "ENSG00000165118" "QNG1" "B2RPI6; hsa:84267; Q5T6V5; Q8N2B1; Q9BT18" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5021225223718005983" "False" "High" "IsMasterProtein" "P31949" "Protein S100-A11 OS=Homo sapiens OX=9606 GN=S100A11 PE=1 SV=2" "0.000" "False" "8.444" "17" "2" "3" "2" "105" "11.7" "7.12" "9.18" "2" "signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00036, Pf01023" "6282" "ENSG00000163191" "S100A11" "hsa:6282; P31949; Q5VTK0" "" "Neutrophil degranulation" "1" "0" "1.091" "1.016" "1.041" "1.048" "1.161" "1.108" "1.202" "1.084" "1.085" "676.9" "738.6" "687.4" "704.4" "709.5" "785.7" "750.2" "813.7" "734.0" "734.5" "" "" "" "" "" "" "" "" "" "" "634.3" "611.2" "638.2" "544.6" "604.7" "750.7" "685.5" "722.5" "734.0" "707.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3328900627537449382" "False" "High" "IsMasterProtein" "Q03111" "Protein ENL OS=Homo sapiens OX=9606 GN=MLLT1 PE=1 SV=2" "0.000" "False" "8.434" "5" "3" "5" "3" "559" "62.0" "8.59" "15.33" "3" "other biological processes" "cytosol;nucleus" "other molecular function" "Pf03366, Pf17793" "4298" "ENSG00000130382" "MLLT1" "hsa:4298; Q03111; Q14768" "" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "3" "0" "0.976" "1.032" "0.943" "0.972" "0.985" "0.944" "1.063" "1.071" "1.036" "135.6" "132.4" "140.0" "127.9" "131.8" "133.5" "128.0" "144.1" "145.2" "140.5" "" "" "" "" "" "" "" "" "" "" "127.1" "109.5" "129.9" "98.9" "112.3" "127.6" "116.9" "127.9" "145.2" "135.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4531692626450091838" "False" "High" "IsMasterProtein" "Q05BQ5" "MBT domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MBTD1 PE=1 SV=2" "0.000" "False" "8.416" "4" "3" "3" "2" "628" "70.5" "7.77" "8.97" "3" "cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02820, Pf21319" "54799" "ENSG00000011258" "MBTD1" "hsa:54799; Q05BQ5; Q6ZVU7; Q9NXU1" "Mesodermal commitment pathway" "" "1" "0" "1.048" "1.141" "0.875" "1.153" "1.116" "1.001" "0.927" "1.025" "1.041" "141.5" "148.3" "161.5" "123.9" "163.2" "157.9" "141.6" "131.2" "145.0" "147.3" "" "" "" "" "" "" "" "" "" "" "132.6" "122.7" "149.9" "95.8" "139.1" "150.9" "129.4" "116.5" "145.0" "141.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2311185762453524816" "False" "High" "IsMasterProtein" "O95905" "Protein ecdysoneless homolog OS=Homo sapiens OX=9606 GN=ECD PE=1 SV=1" "0.000" "False" "8.410" "4" "3" "3" "3" "644" "72.7" "4.87" "9.54" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07093" "11319" "ENSG00000122882" "ECD" "C9JX46; E9PAW8; hsa:11319; O95905" "" "" "0" "0" "1.021" "1.066" "1.065" "1.007" "1.004" "0.903" "0.887" "0.926" "0.995" "213.9" "218.3" "228.1" "227.9" "215.5" "214.8" "193.2" "189.8" "198.0" "212.8" "" "" "" "" "" "" "" "" "" "" "200.4" "180.6" "211.8" "176.2" "183.7" "205.2" "176.5" "168.5" "198.0" "204.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9025151423134884799" "False" "High" "IsMasterProtein" "Q9BY42" "Replication termination factor 2 OS=Homo sapiens OX=9606 GN=RTF2 PE=1 SV=3" "0.000" "False" "8.403" "12" "3" "4" "3" "306" "33.9" "8.59" "13.40" "3" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04641" "51507" "ENSG00000022277" "RTF2" "E1P5Z9; hsa:51507; Q9BY42; Q9BYL7; Q9HCV9; Q9NX29; Q9NZZ8; Q9P002; Q9UHW3" "" "" "0" "0" "1.036" "0.972" "1.054" "0.962" "1.060" "0.991" "1.346" "0.970" "1.135" "276.5" "286.4" "268.7" "291.5" "266.0" "293.1" "274.0" "372.0" "268.2" "313.8" "" "" "" "" "" "" "" "" "" "" "259.0" "237.0" "249.5" "225.4" "226.8" "280.1" "250.4" "330.3" "268.2" "302.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3066040936717898467" "False" "High" "IsMasterProtein" "Q8NC60" "Nitric oxide-associated protein 1 OS=Homo sapiens OX=9606 GN=NOA1 PE=1 SV=2" "0.000" "False" "8.398" "6" "4" "4" "4" "698" "78.4" "8.66" "8.62" "4" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf01926, Pf21516" "84273" "ENSG00000084092" "NOA1" "hsa:84273; Q8N7L6; Q8NC60; Q9BSQ9" "" "" "0" "0" "1.086" "1.059" "1.562" "1.252" "1.046" "1.650" "1.032" "1.086" "0.868" "12.9" "14.0" "13.7" "20.2" "16.2" "13.5" "21.3" "13.3" "14.0" "11.2" "" "" "" "" "" "" "" "" "" "" "12.1" "11.6" "12.7" "15.6" "13.8" "12.9" "19.5" "11.8" "14.0" "10.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4110567019566568697" "False" "High" "IsMasterProtein" "Q9P0U4" "CXXC-type zinc finger protein 1 OS=Homo sapiens OX=9606 GN=CXXC1 PE=1 SV=2" "0.000" "False" "8.371" "5" "3" "6" "3" "656" "75.7" "8.24" "18.97" "3" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf02008, Pf12269" "30827" "ENSG00000154832" "CXXC1" "B2RC03; hsa:30827; Q8N2W4; Q96BC8; Q9P0U4; Q9P2V7" "Male infertility" "XBP1(S) activates chaperone genes; Formation of WDR5-containing histone-modifying complexes" "3" "0" "0.896" "1.015" "0.992" "1.007" "1.010" "0.921" "1.001" "1.075" "1.004" "162.4" "145.5" "164.8" "161.0" "163.6" "164.0" "149.6" "162.5" "174.5" "163.0" "" "" "" "" "" "" "" "" "" "" "152.2" "120.4" "153.0" "124.5" "139.4" "156.7" "136.7" "144.3" "174.5" "156.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2825408205880823904" "False" "High" "IsMasterProtein" "P14635" "G2/mitotic-specific cyclin-B1 OS=Homo sapiens OX=9606 GN=CCNB1 PE=1 SV=1" "0.000" "False" "8.352" "6" "3" "3" "3" "433" "48.3" "7.47" "10.49" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00134, Pf02984" "891" "ENSG00000134057" "CCNB1" "A8K066; hsa:891; P14635; Q5TZP9" "AMP-activated protein kinase signaling; miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATM signaling pathway; G1 to S cell cycle control; GDNF signaling; IL-19 signaling pathway; DNA damage response" "The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of the APC/C; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Cyclin A/B1/B2 associated events during G2/M transition; Transcriptional regulation by RUNX2; MASTL Facilitates Mitotic Progression; E2F-enabled inhibition of pre-replication complex formation; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; Initiation of Nuclear Envelope (NE) Reformation; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Depolymerization of the Nuclear Lamina; Nuclear events stimulated by ALK signaling in cancer; Phosphorylation of Emi1" "33" "0" "1.001" "0.972" "0.922" "0.934" "0.891" "0.919" "0.894" "0.829" "0.936" "985.9" "987.0" "958.4" "908.7" "920.6" "878.1" "906.0" "881.3" "816.9" "922.4" "" "" "" "" "" "" "" "" "" "" "923.8" "816.7" "889.7" "702.5" "784.7" "838.9" "827.8" "782.5" "816.9" "888.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8248162455227524541" "False" "High" "IsMasterProtein" "Q92636" "Protein FAN OS=Homo sapiens OX=9606 GN=NSMAF PE=1 SV=2" "0.000" "False" "8.352" "4" "3" "3" "3" "917" "104.3" "6.23" "11.24" "3" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00400, Pf02138, Pf02893" "8439" "ENSG00000035681" "NSMAF" "B4DFB0; E9PCH0; hsa:8439; Q8IW26; Q92636" "TNF-alpha signaling pathway; Orexin receptor pathway" "TNFR1-mediated ceramide production" "3" "0" "1.004" "0.954" "0.981" "1.012" "1.030" "1.055" "1.040" "1.032" "0.979" "312.4" "313.5" "297.9" "306.5" "316.2" "321.9" "329.6" "324.8" "322.2" "305.9" "" "" "" "" "" "" "" "" "" "" "292.7" "259.4" "276.6" "236.9" "269.5" "307.5" "301.2" "288.4" "322.2" "294.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8505612402410571852" "False" "High" "IsMasterProtein" "P17900" "Ganglioside GM2 activator OS=Homo sapiens OX=9606 GN=GM2A PE=1 SV=4" "0.000" "False" "8.342" "13" "3" "3" "3" "193" "20.8" "5.31" "10.95" "3" "other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;enzyme regulator activity;other molecular function" "Pf02221" "2760" "ENSG00000196743" "GM2A" "B2R699; D3DQH6; hsa:2760; P17900; Q14426; Q14428; Q6LBL5" "Degradation pathway of sphingolipids, including diseases" "Neutrophil degranulation; Glycosphingolipid catabolism" "3" "0" "0.985" "0.989" "1.025" "0.919" "1.002" "0.974" "1.028" "0.959" "0.938" "571.8" "563.3" "565.7" "586.1" "525.3" "572.8" "556.7" "587.8" "548.6" "536.4" "" "" "" "" "" "" "" "" "" "" "535.8" "466.1" "525.2" "453.1" "447.7" "547.2" "508.7" "521.9" "548.6" "516.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "784332711560809760" "False" "High" "IsMasterProtein" "P62072" "Mitochondrial import inner membrane translocase subunit Tim10 OS=Homo sapiens OX=9606 GN=TIMM10 PE=1 SV=1" "0.000" "False" "8.338" "43" "3" "5" "3" "90" "10.3" "6.29" "16.76" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "26519" "ENSG00000134809" "TIMM10" "A8K136; hsa:26519; P62072; Q9WV99; Q9WVA0; Q9Y5J8" "" "Mitochondrial protein degradation; Mitochondrial protein import" "2" "0" "1.065" "1.035" "1.204" "1.130" "1.012" "1.219" "1.127" "1.104" "1.127" "325.8" "346.9" "337.3" "392.2" "368.2" "329.9" "397.3" "367.2" "359.7" "367.3" "" "" "" "" "" "" "" "" "" "" "305.3" "287.1" "313.2" "303.2" "313.9" "315.2" "363.0" "326.1" "359.7" "353.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8342243932904844919" "False" "High" "IsMasterProtein" "Q13555" "Calcium/calmodulin-dependent protein kinase type II subunit gamma OS=Homo sapiens OX=9606 GN=CAMK2G PE=1 SV=4" "0.000" "False" "8.338" "5" "3" "8" "1" "558" "62.6" "7.83" "13.27" "3" "cell-cell signaling;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf08332" "818" "ENSG00000148660" "CAMK2G" "A0A0A0MS52; A0A0A0MT11; hsa:818; O00561; O15378; Q13279; Q13282; Q13555; Q13556; Q5SQZ3; Q5SQZ4; Q5SWX4; Q7KYX5; Q8N4I3; Q8NIA4" "Energy metabolism; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Splicing factor NOVA regulated synaptic proteins; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells; ErbB signaling pathway" "Assembly and cell surface presentation of NMDA receptors; Ion homeostasis; Ion transport by P-type ATPases; Signaling by BRAF and RAF1 fusions; Interferon gamma signaling; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; Regulation of MECP2 expression and activity; Unblocking of NMDA receptors, glutamate binding and activation; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Phase 0 - rapid depolarisation; HSF1-dependent transactivation; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde" "31" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2672477719754299040" "False" "High" "IsMasterProtein" "Q86YB8" "ERO1-like protein beta OS=Homo sapiens OX=9606 GN=ERO1B PE=1 SV=2" "0.000" "False" "8.335" "8" "3" "3" "3" "467" "53.5" "7.99" "8.36" "3" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf04137" "56605" "ENSG00000086619" "ERO1B" "B4DF57; hsa:56605; Q5T1H4; Q86YB8; Q8IZ11; Q9NR62" "" "Insulin processing" "1" "0" "1.478" "1.116" "1.703" "1.363" "1.051" "1.359" "1.208" "1.118" "1.291" "30.7" "45.4" "34.3" "52.3" "41.9" "32.3" "41.8" "37.1" "34.4" "39.7" "" "" "" "" "" "" "" "" "" "" "28.8" "37.6" "31.8" "40.5" "35.7" "30.9" "38.2" "33.0" "34.4" "38.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3574158792208652274" "False" "High" "IsMasterProtein" "O96028" "Histone-lysine N-methyltransferase NSD2 OS=Homo sapiens OX=9606 GN=NSD2 PE=1 SV=1" "0.000" "False" "8.307" "2" "3" "3" "2" "1365" "152.2" "8.69" "9.79" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf00628, Pf00855, Pf00856, Pf17907, Pf17982" "7468" "ENSG00000109685" "NSD2" "A2A2T2; A2A2T3; A2A2T4; A7MCZ1; D3DVQ2; hsa:7468; O96028; O96031; Q4VBY8; Q672J1; Q6IS00; Q86V01; Q9BZB4; Q9UI92; Q9UPR2" "4p16.3 copy number variation" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; PKMTs methylate histone lysines; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "6" "0" "0.984" "0.984" "1.231" "1.121" "1.121" "1.189" "1.012" "1.082" "1.197" "203.5" "200.2" "200.1" "250.5" "228.2" "228.1" "241.8" "206.0" "220.2" "243.6" "" "" "" "" "" "" "" "" "" "" "190.6" "165.7" "185.8" "193.6" "194.5" "217.9" "221.0" "182.9" "220.2" "234.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7247108035044904633" "False" "High" "IsMasterProtein" "P62244" "Small ribosomal subunit protein uS8 OS=Homo sapiens OX=9606 GN=RPS15A PE=1 SV=2" "0.000" "False" "8.303" "24" "4" "6" "4" "130" "14.8" "10.13" "13.80" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00410" "6210" "ENSG00000134419" "RPS15A" "hsa:6210; P39027; P39031; P62244; Q3MHD9; Q8C023; Q9BV24" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.061" "1.002" "0.974" "0.994" "1.052" "1.195" "1.080" "1.074" "1.015" "886.6" "940.6" "888.1" "863.4" "881.0" "932.8" "1059.5" "957.1" "952.1" "900.2" "" "" "" "" "" "" "" "" "" "" "830.7" "778.4" "824.5" "667.5" "751.0" "891.2" "968.1" "849.9" "952.1" "866.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6104701307196402264" "False" "High" "IsMasterProtein" "Q96PE3" "Inositol polyphosphate-4-phosphatase type I A OS=Homo sapiens OX=9606 GN=INPP4A PE=1 SV=1" "0.000" "False" "8.287" "3" "3" "3" "3" "977" "109.9" "6.96" "7.95" "3" "other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "" "3631" "ENSG00000040933" "INPP4A" "hsa:3631; O15326; Q13187; Q53TD8; Q8TC02; Q96PE3" "Insulin signaling" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of IP2, IP, and Ins in the cytosol" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8289862670679680301" "False" "High" "IsMasterProtein" "Q96EK7" "Constitutive coactivator of peroxisome proliferator-activated receptor gamma OS=Homo sapiens OX=9606 GN=FAM120B PE=1 SV=1" "0.000" "False" "8.273" "3" "3" "3" "3" "910" "103.7" "5.69" "8.97" "3" "signal transduction;other biological processes" "nucleus" "" "" "84498" "ENSG00000112584; ENSG00000275333" "FAM120B" "B4DL34; hsa:84498; Q86V68; Q96EK7; Q96JI9" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation" "2" "0" "1.019" "0.989" "1.173" "1.040" "1.053" "1.081" "0.973" "0.937" "1.011" "153.5" "156.5" "151.9" "180.0" "159.6" "161.6" "166.0" "149.5" "143.8" "155.2" "" "" "" "" "" "" "" "" "" "" "143.9" "129.5" "141.0" "139.2" "136.1" "154.4" "151.7" "132.7" "143.8" "149.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5779285951144314922" "False" "High" "IsMasterProtein" "Q8IUH3" "RNA-binding protein 45 OS=Homo sapiens OX=9606 GN=RBM45 PE=1 SV=1" "0.000" "False" "8.273" "5" "3" "4" "3" "476" "53.5" "7.17" "12.01" "3" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "129831" "ENSG00000155636" "RBM45" "hsa:129831; Q6NYL0; Q8IUH3; Q8NFC9" "" "" "0" "0" "1.025" "1.044" "1.118" "1.087" "1.129" "1.058" "1.051" "1.076" "1.095" "405.0" "415.0" "423.0" "452.7" "440.2" "457.1" "428.6" "425.7" "435.9" "443.3" "" "" "" "" "" "" "" "" "" "" "379.5" "343.4" "392.7" "349.9" "375.2" "436.8" "391.7" "378.0" "435.9" "426.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93736052394886069" "False" "High" "IsMasterProtein" "P50583" "Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] OS=Homo sapiens OX=9606 GN=NUDT2 PE=1 SV=3" "0.000" "False" "8.270" "21" "3" "4" "3" "147" "16.8" "5.35" "13.19" "3" "other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf00293" "318" "ENSG00000164978" "NUDT2" "D3DRM0; hsa:318; P50583; Q5T589" "" "Detoxification of Reactive Oxygen Species" "1" "0" "1.035" "0.947" "1.114" "1.030" "0.965" "0.995" "1.020" "0.996" "0.963" "303.1" "313.6" "286.9" "337.6" "312.0" "292.5" "301.6" "309.1" "301.9" "292.0" "" "" "" "" "" "" "" "" "" "" "284.0" "259.5" "266.3" "261.0" "266.0" "279.5" "275.5" "274.5" "301.9" "281.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-567080843799231126" "False" "High" "IsMasterProtein" "Q9NVF7" "F-box only protein 28 OS=Homo sapiens OX=9606 GN=FBXO28 PE=1 SV=1" "0.000" "False" "8.270" "7" "3" "3" "3" "368" "41.1" "9.55" "8.91" "3" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00646" "23219" "ENSG00000143756" "FBXO28" "E9PEM8; hsa:23219; O75070; Q9NVF7" "" "" "0" "0" "0.885" "0.953" "1.007" "0.948" "0.997" "1.016" "1.014" "0.970" "0.963" "366.4" "324.4" "349.1" "368.9" "347.2" "365.3" "372.3" "371.5" "355.5" "352.8" "" "" "" "" "" "" "" "" "" "" "343.3" "268.4" "324.1" "285.2" "296.0" "349.1" "340.2" "329.9" "355.5" "339.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8694247867552348247" "False" "High" "IsMasterProtein" "Q9BQ75" "Protein CMSS1 OS=Homo sapiens OX=9606 GN=CMSS1 PE=1 SV=2" "0.000" "False" "8.247" "10" "3" "3" "3" "279" "31.9" "9.19" "9.00" "3" "" "" "" "Pf14617" "84319" "ENSG00000184220" "CMSS1" "A8K5S7; B4DUM1; E9PHS3; hsa:84319; Q9BQ75" "" "" "0" "0" "1.058" "0.911" "1.578" "1.120" "1.072" "1.343" "0.954" "0.905" "1.075" "70.9" "75.0" "64.6" "111.9" "79.4" "76.0" "95.2" "67.7" "64.2" "76.3" "" "" "" "" "" "" "" "" "" "" "66.5" "62.1" "60.0" "86.5" "67.7" "72.6" "87.0" "60.1" "64.2" "73.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-116543853618974429" "False" "High" "IsMasterProtein" "P20338" "Ras-related protein Rab-4A OS=Homo sapiens OX=9606 GN=RAB4A PE=1 SV=3" "0.000" "False" "8.240" "14" "3" "5" "1" "218" "24.4" "6.07" "14.90" "3" "transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5867" "ENSG00000168118" "RAB4A" "hsa:5867; P20338; Q5T7P7; Q9BQ44" "VEGFA-VEGFR2 signaling; Insulin signaling; Intracellular trafficking proteins involved in CMT neuropathy; 16p11.2 distal deletion syndrome" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Synthesis of PIPs at the plasma membrane; RAB geranylgeranylation; TBC/RABGAPs; MET receptor recycling" "9" "1" "1.886" "0.983" "1.398" "1.419" "1.561" "1.323" "0.989" "1.452" "1.282" "675.8" "1274.7" "664.5" "944.9" "959.0" "1054.8" "894.4" "668.6" "981.6" "866.4" "" "" "" "" "" "" "" "" "" "" "633.3" "1054.8" "616.9" "730.4" "817.5" "1007.8" "817.3" "593.7" "981.6" "834.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4875234499947995187" "False" "High" "IsMasterProtein" "Q93100" "Phosphorylase b kinase regulatory subunit beta OS=Homo sapiens OX=9606 GN=PHKB PE=1 SV=3" "0.000" "False" "8.230" "3" "4" "5" "4" "1093" "124.8" "6.95" "11.99" "4" "other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00723, Pf19292" "5257" "ENSG00000102893" "PHKB" "hsa:5257; Q8N4T5; Q93100" "Glycogen synthesis and degradation" "Glycogen breakdown (glycogenolysis)" "2" "0" "0.944" "0.935" "0.965" "1.041" "0.932" "0.851" "0.865" "0.845" "0.929" "316.1" "298.5" "295.4" "304.9" "329.1" "294.4" "268.9" "273.4" "267.2" "293.5" "" "" "" "" "" "" "" "" "" "" "296.2" "247.0" "274.2" "235.7" "280.5" "281.3" "245.7" "242.7" "267.2" "282.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1467078136555344062" "False" "High" "IsMasterProtein" "Q8NHZ8" "Anaphase-promoting complex subunit CDC26 OS=Homo sapiens OX=9606 GN=CDC26 PE=1 SV=1" "0.000" "False" "8.210" "49" "3" "4" "3" "85" "9.8" "6.81" "10.57" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf10471" "246184" "ENSG00000176386" "CDC26" "hsa:246184; Q8NHZ8" "" "Separation of Sister Chromatids; Assembly of the pre-replicative complex; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "18" "0" "1.033" "1.044" "1.230" "1.097" "1.027" "1.172" "1.028" "0.956" "1.192" "214.9" "221.9" "224.4" "264.3" "235.8" "220.8" "251.9" "220.8" "205.5" "256.2" "" "" "" "" "" "" "" "" "" "" "201.4" "183.6" "208.3" "204.3" "201.0" "210.9" "230.2" "196.1" "205.5" "246.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "208143562843118343" "False" "High" "IsMasterProtein" "Q8NFH5" "Nucleoporin NUP35 OS=Homo sapiens OX=9606 GN=NUP35 PE=1 SV=1" "0.000" "False" "8.204" "12" "3" "3" "3" "326" "34.8" "9.09" "9.80" "3" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05172" "129401" "ENSG00000163002" "NUP35" "B4DP57; B4DYB4; hsa:129401; Q4ZFZ9; Q53S95; Q8NFH5; Q8TDJ1" "" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; HCMV Early Events; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "1.046" "1.007" "1.141" "1.080" "1.096" "1.230" "1.099" "1.138" "1.067" "285.0" "298.1" "287.1" "325.2" "307.7" "312.4" "350.6" "313.1" "324.2" "304.0" "" "" "" "" "" "" "" "" "" "" "267.0" "246.7" "266.5" "251.4" "262.3" "298.5" "320.3" "278.0" "324.2" "292.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-410624310622087342" "False" "High" "IsMasterProtein" "Q13227" "G protein pathway suppressor 2 OS=Homo sapiens OX=9606 GN=GPS2 PE=1 SV=3" "0.000" "False" "8.202" "7" "3" "3" "3" "327" "36.7" "9.52" "7.70" "3" "stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf15991" "2874" "ENSG00000132522; ENSG00000288325" "GPS2" "B4DXA1; hsa:2874; Q13227; Q6FHM8" "Rett syndrome" "HCMV Early Events; HDACs deacetylate histones; PPARA activates gene expression; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3588052474242389854" "False" "High" "IsMasterProtein" "Q92766" "Ras-responsive element-binding protein 1 OS=Homo sapiens OX=9606 GN=RREB1 PE=1 SV=3" "0.000" "False" "8.202" "2" "3" "3" "3" "1687" "181.3" "6.98" "5.35" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13894, Pf13912" "6239" "ENSG00000124782" "RREB1" "A2RRF5; E2GM80; E2GM81; hsa:6239; O75567; O75568; Q5VYB2; Q6BEP5; Q6BEP6; Q6BEP8; Q86SU2; Q92766; Q9Y474" "" "" "0" "0" "1.208" "1.116" "1.185" "1.173" "1.172" "1.183" "1.051" "1.149" "1.351" "111.3" "134.4" "124.1" "131.8" "130.5" "130.4" "131.6" "116.9" "127.8" "150.3" "" "" "" "" "" "" "" "" "" "" "104.2" "111.2" "115.2" "101.9" "111.3" "124.6" "120.3" "103.8" "127.8" "144.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5062141414675458558" "False" "High" "IsMasterProtein" "Q9P0L0" "Vesicle-associated membrane protein-associated protein A OS=Homo sapiens OX=9606 GN=VAPA PE=1 SV=3" "0.000" "False" "8.171" "8" "2" "3" "1" "249" "27.9" "8.62" "8.92" "2" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00635" "9218" "ENSG00000101558" "VAPA" "A6NDZ0; D3DUI3; hsa:9218; O75453; Q5U0E7; Q9P0L0; Q9UBZ2" "Exercise-induced circadian regulation; Cholesterol metabolism" "Neutrophil degranulation; Sphingolipid de novo biosynthesis; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "5" "0" "0.992" "0.940" "0.989" "1.017" "1.091" "1.364" "1.462" "1.483" "1.179" "284.2" "282.0" "267.2" "281.2" "289.1" "310.2" "387.7" "415.5" "421.4" "335.0" "" "" "" "" "" "" "" "" "" "" "266.3" "233.3" "248.1" "217.4" "246.4" "296.4" "354.3" "368.9" "421.4" "322.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2096625671163089170" "False" "High" "IsMasterProtein" "O95999" "B-cell lymphoma/leukemia 10 OS=Homo sapiens OX=9606 GN=BCL10 PE=1 SV=1" "0.000" "False" "8.167" "11" "3" "3" "3" "233" "26.2" "5.74" "9.74" "3" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00619" "8915" "ENSG00000142867" "BCL10" "hsa:8915; O95999; Q5VUF1" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling" "9" "0" "0.959" "0.900" "0.898" "1.033" "0.953" "1.018" "0.926" "0.858" "0.989" "254.0" "243.4" "228.5" "228.1" "262.4" "242.0" "258.6" "235.3" "217.9" "251.1" "" "" "" "" "" "" "" "" "" "" "238.0" "201.4" "212.2" "176.4" "223.6" "231.2" "236.3" "208.9" "217.9" "241.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3738159445275184604" "False" "High" "IsMasterProtein" "Q96SL4" "Glutathione peroxidase 7 OS=Homo sapiens OX=9606 GN=GPX7 PE=1 SV=1" "0.000" "False" "8.160" "16" "4" "7" "4" "187" "21.0" "8.27" "20.62" "4" "stress response;other biological processes" "non-structural extracellular;ER/Golgi" "other molecular function" "Pf00255" "2882" "ENSG00000116157" "GPX7" "hsa:2882; O95337; Q5T501; Q96SL4" "Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways" "Detoxification of Reactive Oxygen Species" "3" "0" "0.959" "0.971" "0.945" "1.004" "1.045" "0.908" "0.973" "0.950" "1.036" "1075.8" "1031.6" "1044.5" "1016.3" "1080.4" "1123.8" "977.1" "1047.1" "1022.0" "1114.6" "" "" "" "" "" "" "" "" "" "" "1008.1" "853.6" "969.7" "785.6" "920.9" "1073.7" "892.8" "929.7" "1022.0" "1073.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1566941551472469516" "False" "High" "IsMasterProtein" "O60508" "Pre-mRNA-processing factor 17 OS=Homo sapiens OX=9606 GN=CDC40 PE=1 SV=1" "0.000" "False" "8.151" "4" "3" "3" "3" "579" "65.5" "7.06" "5.85" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "nucleic acid binding activity" "Pf00400" "51362" "ENSG00000168438" "CDC40" "B2RBC5; hsa:51362; O60508; O75471; Q5SRN0; Q9UPG1" "mRNA processing" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "5" "0" "0.964" "1.053" "1.059" "1.051" "1.067" "1.437" "1.373" "1.294" "1.151" "336.0" "323.8" "353.9" "356.0" "353.2" "358.5" "482.9" "461.2" "434.9" "386.8" "" "" "" "" "" "" "" "" "" "" "314.8" "268.0" "328.5" "275.2" "301.0" "342.5" "441.2" "409.5" "434.9" "372.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9014625147701874173" "False" "High" "IsMasterProtein" "Q5T160" "Probable arginine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=RARS2 PE=1 SV=1" "0.000" "False" "8.144" "5" "3" "3" "3" "578" "65.5" "8.21" "9.32" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf00750, Pf05746" "57038" "ENSG00000146282" "RARS2" "B2RDT7; hsa:57038; Q5T160; Q96FU5; Q9H8K8" "" "Mitochondrial tRNA aminoacylation" "1" "0" "0.990" "1.055" "1.093" "1.060" "1.005" "1.023" "1.006" "1.028" "1.056" "293.1" "290.3" "309.3" "320.5" "310.6" "294.4" "299.9" "295.0" "301.4" "309.6" "" "" "" "" "" "" "" "" "" "" "274.6" "240.2" "287.2" "247.8" "264.8" "281.3" "274.0" "261.9" "301.4" "298.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1544752813938856715" "False" "High" "IsMasterProtein" "Q9H9H4" "Vacuolar protein sorting-associated protein 37B OS=Homo sapiens OX=9606 GN=VPS37B PE=1 SV=1" "0.000" "False" "8.128" "13" "3" "4" "3" "285" "31.3" "7.34" "10.71" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07200" "79720" "ENSG00000139722" "VPS37B" "hsa:79720; Q9H9H4" "7q11.23 copy number variation syndrome" "Late endosomal microautophagy; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Membrane binding and targetting of GAG proteins" "6" "0" "1.104" "1.015" "1.160" "1.171" "1.083" "1.239" "1.238" "1.086" "1.223" "56.7" "62.7" "57.6" "65.8" "66.4" "61.4" "70.3" "70.2" "61.6" "69.4" "" "" "" "" "" "" "" "" "" "" "53.2" "51.9" "53.5" "50.9" "56.6" "58.7" "64.2" "62.4" "61.6" "66.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9153257875265109999" "False" "High" "IsMasterProtein" "Q9NYJ1" "Cytochrome c oxidase assembly factor 4 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=COA4 PE=1 SV=2" "0.000" "False" "8.127" "36" "3" "4" "3" "87" "10.1" "6.04" "16.99" "3" "cell organization and biogenesis" "mitochondrion" "" "Pf06747" "51287" "ENSG00000181924" "COA4" "B2RAA0; hsa:51287; Q69YU4; Q9NYJ1" "" "Mitochondrial protein import" "1" "0" "1.096" "0.963" "1.104" "1.062" "0.946" "0.982" "1.028" "1.006" "1.039" "613.9" "672.6" "591.3" "677.8" "652.1" "580.8" "603.0" "631.2" "617.3" "637.9" "" "" "" "" "" "" "" "" "" "" "575.2" "556.6" "549.0" "524.0" "555.8" "554.9" "551.0" "560.5" "617.3" "614.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7737181066118710012" "False" "High" "IsMasterProtein" "Q8TB40" "(Lyso)-N-acylphosphatidylethanolamine lipase OS=Homo sapiens OX=9606 GN=ABHD4 PE=1 SV=1" "0.000" "False" "8.123" "7" "3" "3" "3" "342" "38.8" "7.59" "8.49" "3" "other metabolic processes;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00561" "63874" "ENSG00000100439" "ABHD4" "B4DDH7; hsa:63874; Q8TB40; Q9H9E0" "" "Acyl chain remodelling of PE" "1" "0" "0.985" "1.051" "0.964" "1.045" "1.027" "0.988" "0.951" "1.040" "1.060" "164.3" "161.9" "172.7" "158.3" "171.8" "168.8" "162.4" "156.2" "170.9" "174.1" "" "" "" "" "" "" "" "" "" "" "154.0" "134.0" "160.3" "122.4" "146.4" "161.3" "148.4" "138.7" "170.9" "167.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3454207587848358751" "False" "High" "IsMasterProtein" "Q9UMN6" "Histone-lysine N-methyltransferase 2B OS=Homo sapiens OX=9606 GN=KMT2B PE=1 SV=1" "0.000" "False" "8.123" "2" "4" "4" "4" "2715" "293.3" "8.22" "7.25" "4" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf00856, Pf02008, Pf05964, Pf05965, Pf13771" "9757" "ENSG00000272333" "KMT2B" "hsa:9757; O15022; O95836; Q96GP2; Q96IP3; Q9UK25; Q9UMN6; Q9Y668; Q9Y669" "Histone modifications" "PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Formation of WDR5-containing histone-modifying complexes" "4" "0" "1.000" "1.026" "0.946" "0.927" "0.999" "0.946" "0.965" "0.923" "0.958" "773.2" "773.2" "793.3" "731.7" "716.9" "772.6" "731.4" "746.0" "713.4" "741.1" "" "" "" "" "" "" "" "" "" "" "724.5" "639.8" "736.5" "565.6" "611.0" "738.2" "668.3" "662.4" "713.4" "713.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1208867046530031718" "False" "High" "IsMasterProtein" "P47813" "Eukaryotic translation initiation factor 1A, X-chromosomal OS=Homo sapiens OX=9606 GN=EIF1AX PE=1 SV=2" "0.000" "False" "8.122" "24" "4" "5" "4" "144" "16.5" "5.24" "14.78" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf01176" "1964" "ENSG00000173674" "EIF1AX" "B2R5U5; hsa:1964; P47813; Q0VGC2; Q5JPS5; Q5JPS6" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "8" "0" "1.098" "1.065" "0.951" "0.965" "0.961" "0.854" "1.048" "1.073" "1.032" "924.5" "1014.8" "984.4" "879.3" "891.8" "888.8" "789.8" "969.0" "991.6" "954.0" "" "" "" "" "" "" "" "" "" "" "866.2" "839.8" "913.9" "679.7" "760.1" "849.1" "721.6" "860.4" "991.6" "918.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7785444937320200778" "False" "High" "IsMasterProtein" "P17544" "Cyclic AMP-dependent transcription factor ATF-7 OS=Homo sapiens OX=9606 GN=ATF7 PE=1 SV=3" "0.000" "False" "8.115" "7" "4" "5" "2" "483" "51.7" "8.00" "10.91" "4" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "11016" "ENSG00000170653" "ATF7" "A5D6Y4; B2RMP1; B4DQL4; hsa:11016; P17544; Q13814; Q8IVR8; Q9UD83" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3279265676386753137" "False" "High" "IsMasterProtein" "Q9BXB4" "Oxysterol-binding protein-related protein 11 OS=Homo sapiens OX=9606 GN=OSBPL11 PE=1 SV=2" "0.000" "False" "8.103" "6" "4" "4" "4" "747" "83.6" "7.06" "9.21" "4" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "114885" "ENSG00000144909" "OSBPL11" "A8K9I7; hsa:114885; Q9BXB4" "" "RHOH GTPase cycle" "1" "0" "1.027" "1.025" "1.192" "1.034" "0.959" "1.154" "1.009" "0.984" "1.056" "163.2" "167.6" "167.2" "194.6" "168.7" "156.4" "188.2" "164.6" "160.6" "172.3" "" "" "" "" "" "" "" "" "" "" "152.9" "138.7" "155.2" "150.4" "143.8" "149.5" "172.0" "146.2" "160.6" "165.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6639760008816947129" "False" "High" "IsMasterProtein" "Q6ZUM4" "Rho GTPase-activating protein 27 OS=Homo sapiens OX=9606 GN=ARHGAP27 PE=1 SV=3" "0.000" "False" "8.100" "3" "3" "3" "3" "889" "98.3" "5.59" "8.32" "3" "transport;signal transduction;other biological processes" "other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00397, Pf00620" "201176" "ENSG00000159314; ENSG00000276836; ENSG00000276907" "ARHGAP27" "A4FU35; A8K3N5; C9JTF3; hsa:201176; Q494U0; Q6NWZ8; Q6ZUM4; Q8WY58" "" "CDC42 GTPase cycle; RAC1 GTPase cycle" "2" "0" "0.853" "0.937" "0.981" "0.950" "0.949" "0.898" "0.950" "0.989" "0.910" "191.6" "163.3" "179.5" "188.0" "182.0" "181.9" "172.1" "182.0" "189.5" "174.4" "" "" "" "" "" "" "" "" "" "" "179.5" "135.2" "166.6" "145.3" "155.1" "173.8" "157.2" "161.6" "189.5" "167.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5693736025540312441" "False" "High" "IsMasterProtein" "P0CG12" "Decreased expression in renal and prostate cancer protein OS=Homo sapiens OX=9606 GN=DERPC PE=1 SV=1" "0.000" "False" "8.092" "6" "3" "3" "3" "524" "51.4" "12.41" "9.88" "3" "" "nucleus" "" "" "" "ENSG00000286140" "DERPC" "A8MYX8; P0CG12; Q71E72; Q8NDH8; Q8WV66; Q9NX73" "" "" "0" "0" "0.969" "1.015" "0.979" "0.952" "0.926" "0.905" "0.958" "0.951" "0.973" "595.1" "576.4" "604.1" "582.9" "566.7" "551.1" "538.6" "570.0" "565.7" "579.0" "" "" "" "" "" "" "" "" "" "" "557.7" "477.0" "560.8" "450.6" "483.0" "526.5" "492.1" "506.1" "565.7" "557.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4534068984681137235" "False" "High" "IsMasterProtein" "Q86WQ0" "Nuclear receptor 2C2-associated protein OS=Homo sapiens OX=9606 GN=NR2C2AP PE=1 SV=1" "0.000" "False" "8.081" "26" "2" "2" "2" "139" "15.9" "6.16" "8.80" "2" "" "nucleus" "" "" "126382" "ENSG00000184162" "NR2C2AP" "A6NGP7; B4DW92; hsa:126382; Q86WQ0" "" "Nuclear Receptor transcription pathway" "1" "0" "1.220" "1.004" "1.199" "1.158" "1.176" "1.159" "1.013" "1.051" "1.059" "155.7" "189.8" "156.2" "186.7" "180.2" "183.1" "180.4" "157.6" "163.6" "164.9" "" "" "" "" "" "" "" "" "" "" "145.9" "157.1" "145.0" "144.3" "153.6" "174.9" "164.8" "140.0" "163.6" "158.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8894202004243013211" "False" "High" "IsMasterProtein" "O15530" "3-phosphoinositide-dependent protein kinase 1 OS=Homo sapiens OX=9606 GN=PDPK1 PE=1 SV=1" "0.000" "False" "8.053" "4" "3" "3" "3" "556" "63.1" "7.36" "9.45" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf14593" "5170" "ENSG00000140992" "PDPK1" "H0Y4Z0; hsa:5170; O15530; Q59EH6; Q6FI20; Q8IV52; Q9BRD5" "MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; Focal adhesion; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PPAR signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Modulators of TCR signaling and T cell activation; GDNF signaling; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway" "Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; G beta:gamma signalling through PI3Kgamma; RHO GTPases activate PKNs; Activation of AKT2; Integrin signaling; RSK activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways" "46" "0" "0.919" "0.995" "1.001" "0.893" "0.952" "0.976" "0.960" "0.972" "0.976" "252.3" "231.7" "250.9" "252.6" "225.4" "240.1" "246.3" "242.1" "245.2" "246.2" "" "" "" "" "" "" "" "" "" "" "236.4" "191.8" "232.9" "195.3" "192.1" "229.4" "225.0" "215.0" "245.2" "237.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4805951626840685734" "False" "High" "IsMasterProtein" "P50336" "Protoporphyrinogen oxidase OS=Homo sapiens OX=9606 GN=PPOX PE=1 SV=1" "0.000" "False" "8.053" "6" "3" "3" "3" "477" "50.7" "8.16" "9.58" "3" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf01593" "5498" "ENSG00000143224" "PPOX" "D3DVG0; hsa:5498; P50336; Q5VTW8" "Orexin receptor pathway; Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "4" "0" "0.999" "0.932" "0.983" "1.007" "1.031" "0.944" "0.939" "0.934" "0.982" "377.5" "377.0" "351.9" "371.1" "380.3" "389.1" "356.4" "354.6" "352.6" "370.8" "" "" "" "" "" "" "" "" "" "" "353.7" "312.0" "326.7" "286.9" "324.2" "371.7" "325.6" "314.8" "352.6" "357.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "75736922320642282" "False" "High" "IsMasterProtein" "O95568" "Histidine protein methyltransferase 1 homolog OS=Homo sapiens OX=9606 GN=METTL18 PE=1 SV=1" "0.000" "False" "8.040" "9" "4" "6" "4" "372" "42.1" "6.76" "16.18" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13489" "92342" "ENSG00000171806" "METTL18" "B2R9T5; hsa:92342; O95568" "" "" "0" "0" "1.110" "1.009" "1.523" "1.153" "0.930" "1.267" "1.035" "1.057" "1.083" "375.1" "416.4" "378.5" "571.1" "432.4" "348.8" "475.3" "388.0" "396.6" "406.4" "" "" "" "" "" "" "" "" "" "" "351.4" "344.6" "351.4" "441.5" "368.6" "333.3" "434.3" "344.5" "396.6" "391.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3162421235115001887" "False" "High" "IsMasterProtein" "L0R819" "ASNSD1 upstream open reading frame protein OS=Homo sapiens OX=9606 GN=ASDURF PE=1 SV=1" "0.000" "False" "8.040" "32" "3" "3" "3" "96" "11.2" "8.88" "8.64" "3" "other biological processes" "other cell component" "" "" "" "ENSG00000286053" "ASDURF" "L0R819" "" "" "0" "0" "0.994" "1.044" "0.978" "1.041" "0.974" "0.942" "0.982" "0.883" "1.025" "508.8" "505.6" "531.0" "497.5" "529.7" "495.6" "479.4" "499.5" "449.3" "521.3" "" "" "" "" "" "" "" "" "" "" "476.7" "418.4" "492.9" "384.6" "451.5" "473.5" "438.0" "443.5" "449.3" "502.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1939715462803938056" "False" "High" "IsMasterProtein" "O75691" "Small subunit processome component 20 homolog OS=Homo sapiens OX=9606 GN=UTP20 PE=1 SV=3" "0.000" "False" "8.040" "1" "4" "4" "4" "2785" "318.2" "7.39" "11.02" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "" "Pf07539, Pf20416" "27340" "ENSG00000120800" "UTP20" "hsa:27340; O75691; Q9H3H4" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.151" "1.053" "1.233" "1.467" "1.177" "1.422" "1.215" "1.262" "1.244" "163.3" "187.9" "171.9" "201.3" "239.6" "192.2" "232.2" "198.4" "206.1" "203.1" "" "" "" "" "" "" "" "" "" "" "153.0" "155.5" "159.6" "155.6" "204.2" "183.6" "212.2" "176.2" "206.1" "195.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7040769112947432832" "False" "High" "IsMasterProtein" "Q96EY1" "DnaJ homolog subfamily A member 3, mitochondrial OS=Homo sapiens OX=9606 GN=DNAJA3 PE=1 SV=2" "0.000" "False" "8.034" "7" "3" "4" "3" "480" "52.5" "9.26" "11.47" "3" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00226, Pf00684, Pf01556" "9093" "ENSG00000103423; ENSG00000276726" "DNAJA3" "B2RAJ5; B4DI33; E7ES32; hsa:9093; O75472; Q8WUJ6; Q8WXJ3; Q96D76; Q96EY1; Q96IV1; Q9NYH8" "" "" "0" "0" "1.062" "1.043" "1.133" "1.150" "1.038" "1.055" "1.026" "1.012" "1.094" "236.0" "250.6" "246.1" "267.3" "271.4" "244.9" "249.0" "242.2" "238.9" "258.1" "" "" "" "" "" "" "" "" "" "" "221.1" "207.4" "228.5" "206.6" "231.3" "234.0" "227.6" "215.0" "238.9" "248.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5575516958920561508" "False" "High" "IsMasterProtein" "Q9H1Y0" "Autophagy protein 5 OS=Homo sapiens OX=9606 GN=ATG5 PE=1 SV=2" "0.000" "False" "8.031" "12" "3" "4" "3" "275" "32.4" "5.77" "7.55" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04106, Pf20637, Pf20638" "9474" "ENSG00000057663" "ATG5" "hsa:9474; O60875; Q5JVR2; Q68DI4; Q9H1Y0; Q9H2B8; Q9HCZ7" "Nanoparticle triggered autophagic cell death; Novel intracellular components of RIG-I-like receptor pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Cytosolic DNA-sensing pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Autophagy; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP" "Negative regulators of DDX58/IFIH1 signaling; Macroautophagy; PINK1-PRKN Mediated Mitophagy; Receptor Mediated Mitophagy" "13" "0" "1.044" "1.075" "1.143" "1.115" "1.076" "1.063" "1.076" "1.017" "1.112" "260.4" "271.7" "280.0" "297.6" "290.3" "280.1" "276.6" "280.2" "264.8" "289.6" "" "" "" "" "" "" "" "" "" "" "244.0" "224.8" "259.9" "230.0" "247.4" "267.6" "252.8" "248.8" "264.8" "278.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6383269344633082517" "False" "High" "IsMasterProtein" "Q8WTW3" "Conserved oligomeric Golgi complex subunit 1 OS=Homo sapiens OX=9606 GN=COG1 PE=1 SV=1" "0.000" "False" "8.026" "3" "3" "4" "3" "980" "108.9" "7.31" "7.82" "3" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi" "" "Pf08700" "9382" "ENSG00000166685" "COG1" "hsa:9382; Q8WTW3; Q9NPV9; Q9P2G6" "" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8772663144839085983" "False" "High" "IsMasterProtein" "O14965" "Aurora kinase A OS=Homo sapiens OX=9606 GN=AURKA PE=1 SV=3" "0.000" "False" "8.001" "6" "2" "4" "2" "403" "45.8" "9.39" "7.00" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6790" "ENSG00000087586" "AURKA" "E1P5F9; hsa:6790; O14965; O60445; O75873; Q9BQD6; Q9UPG5" "Gastric cancer network 1; EGF/EGFR signaling pathway; p53 transcriptional gene network; HDAC6 interactions in the central nervous system" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; SUMOylation of DNA replication proteins; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Interaction between PHLDA1 and AURKA" "12" "0" "1.066" "0.838" "0.863" "0.818" "0.885" "0.853" "0.831" "0.693" "0.869" "30.5" "32.5" "25.5" "26.3" "24.9" "27.0" "26.0" "25.3" "21.1" "26.5" "" "" "" "" "" "" "" "" "" "" "28.5" "26.9" "23.7" "20.3" "21.3" "25.8" "23.7" "22.5" "21.1" "25.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7569413463716614588" "False" "High" "IsMasterProtein" "Q8N6M0" "Deubiquitinase OTUD6B OS=Homo sapiens OX=9606 GN=OTUD6B PE=1 SV=1" "0.000" "False" "7.986" "11" "4" "4" "4" "293" "33.8" "6.05" "12.38" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf02338" "51633" "ENSG00000155100" "OTUD6B" "A8K6I1; B4DEY0; hsa:51633; Q8N6M0; Q9NTA4; Q9Y387" "Warburg effect modulated by deubiquitinating enzymes and their substrates" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1082810895474363705" "False" "High" "IsMasterProtein" "P06746" "DNA polymerase beta OS=Homo sapiens OX=9606 GN=POLB PE=1 SV=3" "0.000" "False" "7.981" "10" "3" "4" "3" "335" "38.2" "8.95" "11.78" "3" "DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf10391, Pf14716, Pf14791, Pf14792" "5423" "ENSG00000070501" "POLB" "B2RC78; hsa:5423; P06746; Q3KP48; Q6FI34" "Male infertility; Base excision repair; DNA repair pathways, full network" "Ub-specific processing proteases; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-390863097898701106" "False" "High" "IsMasterProtein" "Q14657" "EKC/KEOPS complex subunit LAGE3 OS=Homo sapiens OX=9606 GN=LAGE3 PE=1 SV=2" "0.000" "False" "7.976" "26" "3" "4" "3" "143" "14.8" "8.63" "15.99" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf09341" "8270" "ENSG00000196976" "LAGE3" "hsa:8270; Q14657; Q5HY39; Q8IZ78" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.072" "1.001" "1.025" "0.952" "0.973" "1.042" "1.056" "1.038" "0.993" "337.0" "361.2" "337.3" "345.5" "320.9" "327.8" "351.0" "355.8" "349.8" "334.5" "" "" "" "" "" "" "" "" "" "" "315.8" "298.9" "313.2" "267.1" "273.5" "313.1" "320.8" "316.0" "349.8" "322.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5049084120360688973" "False" "High" "IsMasterProtein" "Q6PL24" "Protein TMED8 OS=Homo sapiens OX=9606 GN=TMED8 PE=1 SV=1" "0.000" "False" "7.964" "9" "3" "3" "3" "325" "35.7" "4.74" "10.14" "3" "" "" "" "Pf13897" "283578" "ENSG00000100580" "TMED8" "B3KTI6; hsa:283578; Q3MJB0; Q6PL24; Q9P1V9" "" "" "0" "0" "1.156" "1.000" "1.137" "1.106" "1.033" "1.109" "0.915" "1.031" "1.095" "182.0" "210.5" "181.9" "206.9" "201.2" "187.9" "201.8" "166.4" "187.7" "199.2" "" "" "" "" "" "" "" "" "" "" "170.5" "174.2" "168.9" "159.9" "171.5" "179.6" "184.4" "147.8" "187.7" "191.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8531201272546720497" "False" "High" "IsMasterProtein" "P14854" "Cytochrome c oxidase subunit 6B1 OS=Homo sapiens OX=9606 GN=COX6B1 PE=1 SV=2" "0.000" "False" "7.953" "27" "3" "6" "3" "86" "10.2" "7.05" "18.44" "3" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf02297" "1340" "ENSG00000126267" "COX6B1" "B2R5C9; hsa:1340; P14854; Q6IBL4" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes" "7" "0" "1.053" "1.027" "0.935" "0.980" "0.935" "0.856" "0.848" "0.838" "0.952" "1467.5" "1545.9" "1507.7" "1372.6" "1438.8" "1371.4" "1255.5" "1243.9" "1229.3" "1396.6" "" "" "" "" "" "" "" "" "" "" "1375.0" "1279.2" "1399.7" "1061.1" "1226.4" "1310.2" "1147.2" "1104.4" "1229.3" "1344.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1732426368668540463" "False" "High" "IsMasterProtein" "Q8N9N8" "Probable RNA-binding protein EIF1AD OS=Homo sapiens OX=9606 GN=EIF1AD PE=1 SV=1" "0.000" "False" "7.952" "20" "2" "2" "2" "165" "19.0" "5.21" "9.22" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01176" "84285" "ENSG00000175376" "EIF1AD" "B2R4N5; hsa:84285; Q8N9N8; Q9BSC1" "" "" "0" "0" "1.054" "0.947" "1.079" "1.014" "1.088" "1.055" "1.056" "1.066" "1.097" "149.3" "157.3" "141.3" "161.1" "151.4" "162.4" "157.4" "157.6" "159.1" "163.7" "" "" "" "" "" "" "" "" "" "" "139.9" "130.2" "131.2" "124.5" "129.0" "155.1" "143.9" "140.0" "159.1" "157.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3551068469878704149" "False" "High" "IsMasterProtein" "Q9H0U6" "Large ribosomal subunit protein uL18m OS=Homo sapiens OX=9606 GN=MRPL18 PE=1 SV=1" "0.000" "False" "7.951" "17" "3" "3" "3" "180" "20.6" "9.54" "10.03" "3" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00861" "29074" "ENSG00000112110" "MRPL18" "hsa:29074; Q5TAP9; Q9H0U6; Q9NZW8" "" "Mitochondrial translation elongation; Mitochondrial translation initiation; Mitochondrial translation termination" "3" "0" "1.047" "1.025" "1.163" "1.016" "1.132" "1.102" "1.095" "0.935" "1.098" "170.3" "178.3" "174.5" "198.0" "173.0" "192.7" "187.7" "186.5" "159.3" "187.1" "" "" "" "" "" "" "" "" "" "" "159.6" "147.5" "162.0" "153.1" "147.5" "184.1" "171.5" "165.6" "159.3" "180.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5802267777781672264" "False" "High" "IsMasterProtein" "O43665" "Regulator of G-protein signaling 10 OS=Homo sapiens OX=9606 GN=RGS10 PE=1 SV=3" "0.000" "False" "7.942" "16" "2" "2" "2" "181" "21.2" "7.49" "10.16" "2" "cell-cell signaling;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00615" "6001" "ENSG00000148908" "RGS10" "A8K408; B1AMR8; hsa:6001; O43665; Q6IAZ6; Q96GN0" "Mesodermal commitment pathway; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "G alpha (i) signalling events" "4" "0" "1.040" "1.002" "0.925" "1.022" "0.944" "0.766" "0.846" "0.795" "0.919" "197.2" "205.0" "197.6" "182.4" "201.5" "186.2" "151.0" "166.9" "156.8" "181.3" "" "" "" "" "" "" "" "" "" "" "184.8" "169.7" "183.5" "141.0" "171.7" "177.9" "137.9" "148.2" "156.8" "174.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1389983804562693885" "False" "High" "IsMasterProtein" "A2RUC4" "tRNA wybutosine-synthesizing protein 5 OS=Homo sapiens OX=9606 GN=TYW5 PE=1 SV=1" "0.000" "False" "7.934" "12" "4" "4" "4" "315" "36.5" "7.55" "10.93" "4" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf13621" "129450" "ENSG00000162971" "TYW5" "A2RUC4; B2RNE3; hsa:129450; Q8N1R2" "" "Synthesis of wybutosine at G37 of tRNA(Phe)" "1" "0" "0.938" "1.059" "1.117" "1.033" "1.090" "1.134" "1.123" "1.050" "1.075" "181.0" "169.9" "191.8" "202.3" "187.0" "197.3" "205.3" "203.2" "190.0" "194.7" "" "" "" "" "" "" "" "" "" "" "169.6" "140.6" "178.0" "156.4" "159.4" "188.5" "187.6" "180.5" "190.0" "187.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8392578490847645683" "False" "High" "IsMasterProtein" "Q9NR33" "DNA polymerase epsilon subunit 4 OS=Homo sapiens OX=9606 GN=POLE4 PE=1 SV=2" "0.000" "False" "7.933" "30" "2" "2" "2" "117" "12.2" "4.92" "9.44" "2" "DNA metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "56655" "ENSG00000115350" "POLE4" "Q53TR2; Q9NR33" "Pyrimidine metabolism; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Dual Incision in GG-NER; Activation of the pre-replicative complex; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; DNA replication initiation; Gap-filling DNA repair synthesis and ligation in GG-NER" "16" "0" "1.092" "1.001" "1.103" "1.334" "1.223" "1.309" "0.974" "1.239" "0.965" "40.5" "44.2" "40.5" "44.6" "54.0" "49.5" "53.0" "39.4" "50.1" "39.0" "" "" "" "" "" "" "" "" "" "" "37.9" "36.6" "37.6" "34.5" "46.0" "47.3" "48.4" "35.0" "50.1" "37.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4967906594537230573" "False" "High" "IsMasterProtein" "Q9NUG6" "p53 and DNA damage-regulated protein 1 OS=Homo sapiens OX=9606 GN=PDRG1 PE=1 SV=2" "0.000" "False" "7.924" "21" "3" "4" "3" "133" "15.5" "6.06" "12.51" "3" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "81572" "ENSG00000088356" "PDRG1" "B2R511; hsa:81572; Q96GP3; Q9BUW8; Q9NUG6" "" "" "0" "0" "1.000" "0.975" "0.985" "1.022" "1.042" "1.031" "1.032" "0.963" "1.027" "764.7" "764.5" "745.5" "752.9" "781.3" "796.5" "788.3" "789.5" "736.1" "785.1" "" "" "" "" "" "" "" "" "" "" "716.5" "632.6" "692.1" "582.0" "666.0" "761.0" "720.3" "701.0" "736.1" "755.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3764290193644051117" "False" "High" "IsMasterProtein" "Q8WU10" "Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PYROXD1 PE=1 SV=1" "0.000" "False" "7.916" "7" "3" "3" "3" "500" "55.8" "5.85" "8.81" "3" "stress response" "cytoskeleton;nucleus" "other molecular function" "Pf07992, Pf18267" "79912" "ENSG00000121350" "PYROXD1" "A6NKI6; B3KWN8; hsa:79912; Q8WU10; Q9H6P1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5232175681869918932" "False" "High" "IsMasterProtein" "Q14678" "KN motif and ankyrin repeat domain-containing protein 1 OS=Homo sapiens OX=9606 GN=KANK1 PE=1 SV=3" "0.000" "False" "7.915" "2" "3" "3" "3" "1352" "147.2" "5.30" "9.25" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00023, Pf12075" "23189" "ENSG00000107104" "KANK1" "A2A2W8; D3DRH3; hsa:23189; Q14678; Q5W0W0; Q8IY65; Q8WX74" "VEGFA-VEGFR2 signaling" "Estrogen-dependent gene expression; Signaling by membrane-tethered fusions of PDGFRA or PDGFRB" "3" "0" "1.002" "0.988" "1.017" "1.023" "0.956" "0.985" "0.899" "0.934" "1.056" "382.2" "383.1" "377.5" "388.6" "391.0" "365.3" "376.5" "343.8" "357.1" "403.6" "" "" "" "" "" "" "" "" "" "" "358.2" "317.0" "350.4" "300.4" "333.3" "349.0" "344.0" "305.3" "357.1" "388.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5878749091954707236" "False" "High" "IsMasterProtein" "Q9NXA8" "NAD-dependent protein deacylase sirtuin-5, mitochondrial OS=Homo sapiens OX=9606 GN=SIRT5 PE=1 SV=2" "0.000" "False" "7.908" "11" "2" "2" "2" "310" "33.9" "8.47" "8.42" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf02146" "23408" "ENSG00000124523" "SIRT5" "B4DFM4; B4DYJ5; F5H5Z9; hsa:23408; Q5T294; Q5T295; Q9NXA8; Q9Y6E6" "NAD+ metabolism; NAD+ biosynthetic pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence" "Transcriptional activation of mitochondrial biogenesis" "4" "0" "1.011" "1.020" "0.992" "1.133" "0.993" "1.042" "1.091" "1.091" "1.071" "255.4" "258.2" "260.5" "253.4" "289.4" "253.7" "266.0" "278.6" "278.6" "273.7" "" "" "" "" "" "" "" "" "" "" "239.3" "213.6" "241.8" "195.9" "246.7" "242.3" "243.1" "247.4" "278.6" "263.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9147063981897791280" "False" "High" "IsMasterProtein" "P04632" "Calpain small subunit 1 OS=Homo sapiens OX=9606 GN=CAPNS1 PE=1 SV=1" "0.000" "False" "7.884" "10" "2" "5" "2" "268" "28.3" "5.20" "22.04" "2" "protein metabolism;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "" "826" "ENSG00000126247" "CAPNS1" "A8K0P1; hsa:826; P04632; Q8WTX3; Q96EW0" "Integrin-mediated cell adhesion" "Formation of the cornified envelope; Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "4" "0" "0.971" "0.960" "0.957" "0.984" "1.006" "0.977" "0.962" "0.949" "0.900" "532.7" "517.3" "511.7" "509.8" "524.2" "536.0" "520.4" "512.5" "505.5" "479.5" "" "" "" "" "" "" "" "" "" "" "499.2" "428.0" "475.0" "394.1" "446.8" "512.1" "475.5" "455.0" "505.5" "461.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5853825877774435955" "False" "High" "IsMasterProtein" "Q96HQ2" "CDKN2AIP N-terminal-like protein OS=Homo sapiens OX=9606 GN=CDKN2AIPNL PE=1 SV=1" "0.000" "False" "7.872" "25" "2" "4" "2" "116" "13.2" "5.00" "17.26" "2" "" "" "" "Pf11952" "91368" "ENSG00000237190" "CDKN2AIPNL" "hsa:91368; Q8WVE3; Q96HQ2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-476586099519423561" "False" "High" "IsMasterProtein" "Q9UI43" "rRNA methyltransferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=MRM2 PE=1 SV=1" "0.000" "False" "7.872" "13" "3" "4" "3" "246" "27.4" "9.50" "11.75" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf01728" "29960" "ENSG00000122687" "MRM2" "hsa:29960; Q24JR8; Q9UI43" "" "rRNA modification in the mitochondrion" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7498907094133803237" "False" "High" "IsMasterProtein" "A4D1P6" "WD repeat-containing protein 91 OS=Homo sapiens OX=9606 GN=WDR91 PE=1 SV=2" "0.000" "False" "7.866" "4" "3" "5" "3" "747" "83.3" "6.58" "10.58" "3" "transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle" "enzyme regulator activity" "Pf00400, Pf12894" "29062" "ENSG00000105875" "WDR91" "A4D1P6; A6NK54; C9JMI4; hsa:29062; Q6FI65; Q6MZQ1; Q6P4I1; Q96AE5; Q96G63; Q9H062; Q9H9B6; Q9NVG7; Q9NZY6" "" "CDC42 GTPase cycle" "1" "0" "0.940" "0.914" "1.054" "1.007" "0.980" "0.966" "0.898" "1.013" "0.959" "262.5" "246.9" "239.8" "276.7" "264.4" "257.3" "253.6" "235.8" "265.9" "251.6" "" "" "" "" "" "" "" "" "" "" "246.0" "204.3" "222.6" "213.9" "225.4" "245.8" "231.7" "209.4" "265.9" "242.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4801504579459921117" "False" "High" "IsMasterProtein" "Q8IXQ3" "Uncharacterized protein C9orf40 OS=Homo sapiens OX=9606 GN=C9orf40 PE=1 SV=1" "0.000" "False" "7.865" "14" "2" "3" "2" "194" "21.1" "5.01" "12.74" "2" "" "" "" "Pf15017" "55071" "ENSG00000135045" "C9orf40" "hsa:55071; Q8IXQ3; Q9NWD3" "" "" "0" "0" "1.065" "1.007" "0.917" "0.952" "1.005" "0.908" "0.932" "0.830" "0.956" "414.1" "441.0" "417.2" "379.6" "394.1" "416.3" "376.1" "386.1" "343.7" "396.0" "" "" "" "" "" "" "" "" "" "" "388.0" "364.9" "387.3" "293.4" "335.9" "397.7" "343.6" "342.8" "343.7" "381.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1613875613327361847" "False" "High" "IsMasterProtein" "Q96G25" "Mediator of RNA polymerase II transcription subunit 8 OS=Homo sapiens OX=9606 GN=MED8 PE=1 SV=2" "0.000" "False" "7.862" "10" "3" "3" "3" "268" "29.1" "7.44" "6.63" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10232" "112950" "ENSG00000159479" "MED8" "A9IZ91; A9IZ92; hsa:112950; Q5JUY8; Q96FQ4; Q96G25" "" "Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "4" "0" "0.991" "0.979" "0.995" "0.956" "0.927" "1.019" "1.007" "1.078" "1.004" "424.6" "420.8" "415.6" "422.5" "405.8" "393.7" "432.6" "427.5" "457.5" "426.4" "" "" "" "" "" "" "" "" "" "" "397.8" "348.2" "385.9" "326.6" "345.9" "376.2" "395.3" "379.6" "457.5" "410.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8781078747776304120" "False" "High" "IsMasterProtein" "Q9NY12" "H/ACA ribonucleoprotein complex subunit 1 OS=Homo sapiens OX=9606 GN=GAR1 PE=1 SV=1" "0.000" "False" "7.862" "16" "3" "4" "3" "217" "22.3" "10.92" "10.44" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf04410" "54433" "ENSG00000109534" "GAR1" "hsa:54433; Q5MJQ2; Q9NY12" "" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "2" "0" "1.271" "1.179" "1.118" "1.091" "1.015" "1.136" "1.109" "1.133" "1.156" "183.4" "233.1" "216.1" "204.9" "200.1" "186.1" "208.3" "203.4" "207.8" "211.9" "" "" "" "" "" "" "" "" "" "" "171.8" "192.9" "200.6" "158.4" "170.6" "177.8" "190.3" "180.6" "207.8" "204.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "653544174487068262" "False" "High" "IsMasterProtein" "O00479" "High mobility group nucleosome-binding domain-containing protein 4 OS=Homo sapiens OX=9606 GN=HMGN4 PE=1 SV=3" "0.000" "False" "7.860" "27" "3" "3" "3" "90" "9.5" "10.48" "10.49" "3" "cell organization and biogenesis" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "10473" "ENSG00000182952; ENSG00000292175" "HMGN4" "B2R4I6; hsa:10473; O00479; Q53XL9" "" "" "0" "0" "1.119" "1.027" "1.092" "1.093" "1.035" "0.957" "1.197" "1.119" "1.055" "747.0" "835.9" "767.3" "815.8" "816.2" "773.1" "715.3" "894.1" "836.3" "788.3" "" "" "" "" "" "" "" "" "" "" "700.0" "691.7" "712.3" "630.7" "695.7" "738.6" "653.6" "793.9" "836.3" "759.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3573603970106114423" "False" "High" "IsMasterProtein" "Q9H2F5" "Enhancer of polycomb homolog 1 OS=Homo sapiens OX=9606 GN=EPC1 PE=1 SV=1" "0.000" "False" "7.856" "2" "2" "4" "1" "836" "93.4" "8.59" "10.06" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf06752, Pf10513" "80314" "ENSG00000120616" "EPC1" "B4DSC3; D3DRX7; hsa:80314; Q5VW54; Q5VW56; Q5VW58; Q8NAQ4; Q8NE21; Q96LF4; Q96RR6; Q9H2F5; Q9H7T7" "" "Transcriptional Regulation by E2F6; HATs acetylate histones" "2" "1" "1.123" "1.162" "1.203" "1.176" "1.175" "1.023" "1.050" "0.981" "1.099" "133.2" "149.6" "154.8" "160.3" "156.7" "156.6" "136.4" "139.9" "130.7" "146.4" "" "" "" "" "" "" "" "" "" "" "124.9" "123.8" "143.7" "123.9" "133.6" "149.6" "124.6" "124.3" "130.7" "140.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2227008394942671266" "False" "High" "IsMasterProtein" "Q9BUQ8" "Probable ATP-dependent RNA helicase DDX23 OS=Homo sapiens OX=9606 GN=DDX23 PE=1 SV=3" "0.000" "False" "7.855" "3" "3" "3" "3" "820" "95.5" "9.55" "8.30" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271" "9416" "ENSG00000174243" "DDX23" "B2R600; B4DH15; hsa:9416; O43188; Q9BUQ8" "" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "2" "0" "1.175" "1.210" "1.033" "1.107" "0.967" "1.394" "1.101" "1.127" "1.067" "104.3" "122.6" "126.2" "107.8" "115.5" "100.9" "145.4" "114.9" "117.5" "111.4" "" "" "" "" "" "" "" "" "" "" "97.8" "101.5" "117.2" "83.3" "98.5" "96.4" "132.9" "102.0" "117.5" "107.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1307074189875800146" "False" "High" "IsMasterProtein" "O14732" "Inositol monophosphatase 2 OS=Homo sapiens OX=9606 GN=IMPA2 PE=1 SV=1" "0.000" "False" "7.854" "8" "3" "3" "3" "288" "31.3" "6.61" "9.90" "3" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00459" "3613" "ENSG00000141401" "IMPA2" "B0YJ29; hsa:3613; O14732; Q9UJT3" "" "Synthesis of IP2, IP, and Ins in the cytosol" "1" "0" "0.981" "0.901" "1.003" "0.914" "1.006" "0.958" "0.925" "0.960" "0.989" "221.9" "217.7" "199.9" "222.7" "202.9" "223.3" "212.6" "205.3" "213.1" "219.5" "" "" "" "" "" "" "" "" "" "" "207.9" "180.1" "185.6" "172.1" "173.0" "213.3" "194.3" "182.3" "213.1" "211.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9084351700158867792" "False" "High" "IsMasterProtein" "Q9HD33" "Large ribosomal subunit protein uL29m OS=Homo sapiens OX=9606 GN=MRPL47 PE=1 SV=2" "0.000" "False" "7.844" "11" "3" "3" "3" "250" "29.4" "10.37" "5.90" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf06984" "57129" "ENSG00000136522" "MRPL47" "hsa:57129; Q6XRG1; Q8N5D1; Q9HD33" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.918" "0.966" "0.956" "0.913" "0.989" "0.946" "0.881" "0.939" "0.908" "413.3" "379.3" "399.4" "395.1" "377.2" "408.8" "391.2" "364.0" "388.1" "375.4" "" "" "" "" "" "" "" "" "" "" "387.2" "313.8" "370.8" "305.4" "321.5" "390.5" "357.4" "323.2" "388.1" "361.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5379927886480691395" "False" "High" "IsMasterProtein" "O95456" "Proteasome assembly chaperone 1 OS=Homo sapiens OX=9606 GN=PSMG1 PE=1 SV=1" "0.000" "False" "7.842" "11" "3" "5" "3" "288" "32.8" "7.17" "15.93" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf16094" "8624" "ENSG00000183527" "PSMG1" "B5BUN2; hsa:8624; O95456; Q6FHA3; Q6FHD3; Q6S713" "" "" "0" "0" "1.020" "0.996" "1.082" "0.969" "1.003" "1.028" "1.012" "1.000" "1.003" "596.2" "607.8" "594.0" "644.8" "577.8" "598.3" "613.1" "603.5" "596.0" "598.0" "" "" "" "" "" "" "" "" "" "" "558.6" "503.0" "551.5" "498.5" "492.5" "571.6" "560.2" "535.8" "596.0" "575.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5446146544739154360" "False" "High" "IsMasterProtein" "Q15654" "Thyroid receptor-interacting protein 6 OS=Homo sapiens OX=9606 GN=TRIP6 PE=1 SV=3" "0.000" "False" "7.838" "7" "2" "2" "2" "476" "50.3" "7.37" "10.23" "2" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00412" "7205" "ENSG00000087077" "TRIP6" "A4D2E7; F2ZC07; F2ZC08; hsa:7205; O15170; O15275; Q15654; Q9BTB2; Q9BUE5; Q9BXP3; Q9UNT4" "" "" "0" "0" "0.940" "0.841" "0.880" "0.880" "0.856" "0.972" "0.883" "0.851" "0.857" "286.3" "269.1" "240.8" "251.8" "252.0" "245.1" "278.3" "252.7" "243.6" "245.2" "" "" "" "" "" "" "" "" "" "" "268.2" "222.6" "223.5" "194.7" "214.8" "234.1" "254.3" "224.4" "243.6" "236.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-486676491892428044" "False" "High" "IsMasterProtein" "Q92759" "General transcription factor IIH subunit 4 OS=Homo sapiens OX=9606 GN=GTF2H4 PE=1 SV=1" "0.000" "False" "7.835" "5" "3" "5" "3" "462" "52.2" "9.04" "12.75" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03849, Pf18307" "2968" "ENSG00000213780; ENSG00000221974; ENSG00000226384; ENSG00000233149; ENSG00000234370; ENSG00000236895" "GTF2H4" "B4DTJ5; hsa:2968; Q76KU4; Q92759" "Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA Polymerase I Transcription Initiation; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "33" "0" "0.951" "1.047" "1.158" "1.108" "0.975" "1.076" "1.177" "1.219" "1.010" "165.3" "157.2" "173.1" "191.4" "183.3" "161.2" "177.9" "194.6" "201.5" "166.9" "" "" "" "" "" "" "" "" "" "" "154.9" "130.1" "160.7" "148.0" "156.2" "154.0" "162.5" "172.8" "201.5" "160.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3119089922168410835" "False" "High" "IsMasterProtein" "P10606" "Cytochrome c oxidase subunit 5B, mitochondrial OS=Homo sapiens OX=9606 GN=COX5B PE=1 SV=2" "0.000" "False" "7.833" "24" "3" "5" "3" "129" "13.7" "8.81" "13.31" "3" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf01215" "1329" "ENSG00000135940; ENSG00000291596" "COX5B" "hsa:1329; P10606; Q53YB7; Q96J18; Q99610" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial protein degradation" "8" "0" "1.137" "1.075" "1.102" "1.200" "1.116" "1.093" "1.086" "1.058" "1.086" "175.5" "199.6" "188.6" "193.4" "210.7" "195.8" "191.8" "190.6" "185.7" "190.6" "" "" "" "" "" "" "" "" "" "" "164.4" "165.2" "175.1" "149.5" "179.6" "187.1" "175.2" "169.3" "185.7" "183.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8196142567442196869" "False" "High" "IsMasterProtein" "P20645" "Cation-dependent mannose-6-phosphate receptor OS=Homo sapiens OX=9606 GN=M6PR PE=1 SV=1" "0.000" "False" "7.824" "13" "2" "2" "2" "277" "31.0" "5.83" "9.40" "2" "transport" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02157" "4074" "ENSG00000003056" "M6PR" "A8K528; D3DUV5; hsa:4074; P20645" "" "Glycosphingolipid catabolism; Retrograde transport at the Trans-Golgi-Network; Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis" "5" "0" "0.984" "0.987" "1.110" "1.057" "1.007" "1.031" "1.017" "1.079" "1.078" "139.6" "137.4" "137.9" "155.0" "147.6" "140.6" "143.9" "142.1" "150.7" "150.5" "" "" "" "" "" "" "" "" "" "" "130.8" "113.7" "128.0" "119.8" "125.8" "134.4" "131.5" "126.1" "150.7" "144.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8306155883597695001" "False" "High" "IsMasterProtein" "Q9NTM9" "Copper homeostasis protein cutC homolog OS=Homo sapiens OX=9606 GN=CUTC PE=1 SV=1" "0.000" "False" "7.823" "10" "3" "3" "3" "273" "29.3" "8.18" "8.92" "3" "cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03932" "51076" "ENSG00000119929" "CUTC" "hsa:51076; Q5TCZ8; Q9NTM9; Q9Y321" "" "Ion transport by P-type ATPases" "1" "0" "1.005" "0.989" "1.048" "0.997" "1.203" "0.986" "1.014" "1.045" "1.103" "330.8" "332.3" "327.3" "346.8" "329.7" "397.9" "326.0" "335.4" "345.9" "364.9" "" "" "" "" "" "" "" "" "" "" "310.0" "275.0" "303.8" "268.1" "281.0" "380.2" "297.9" "297.8" "345.9" "351.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2544930509745837934" "False" "High" "IsMasterProtein" "P81877" "Single-stranded DNA-binding protein 2 OS=Homo sapiens OX=9606 GN=SSBP2 PE=1 SV=2" "0.000" "False" "7.823" "6" "2" "3" "1" "361" "37.8" "6.64" "11.75" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04503" "23635" "ENSG00000145687" "SSBP2" "B2R5W1; B7Z1J2; B7Z2L9; B7Z665; D6RH18; E9PB74; E9PDA8; hsa:23635; P81877; Q8N2Q2; Q9BWW6; Q9Y4T7" "" "" "0" "0" "0.968" "0.728" "0.868" "1.050" "1.070" "0.974" "0.957" "0.969" "1.041" "61.9" "59.9" "45.0" "53.7" "65.0" "66.2" "60.2" "59.2" "60.0" "64.4" "" "" "" "" "" "" "" "" "" "" "58.0" "49.6" "41.8" "41.5" "55.4" "63.3" "55.0" "52.6" "60.0" "62.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5541205227018029514" "False" "High" "IsMasterProtein" "Q9H0P0" "Cytosolic 5'-nucleotidase 3A OS=Homo sapiens OX=9606 GN=NT5C3A PE=1 SV=3" "0.000" "False" "7.820" "10" "3" "5" "3" "336" "37.9" "7.12" "15.66" "3" "other metabolic processes;stress response" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf05822" "51251" "ENSG00000122643" "NT5C3A" "A8K253; B2RAA5; B8ZZC4; hsa:51251; Q6IPZ1; Q6NXS6; Q7L3G6; Q9H0P0; Q9P0P5; Q9UC42; Q9UC43; Q9UC44; Q9UC45" "" "" "0" "0" "1.023" "1.015" "1.134" "1.068" "1.032" "1.076" "0.955" "0.976" "1.030" "313.5" "320.7" "318.1" "355.4" "334.8" "323.6" "337.3" "299.5" "306.1" "322.9" "" "" "" "" "" "" "" "" "" "" "293.7" "265.4" "295.3" "274.7" "285.3" "309.1" "308.2" "265.9" "306.1" "310.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6036677964263745223" "False" "High" "IsMasterProtein" "Q8NFH4" "Nucleoporin Nup37 OS=Homo sapiens OX=9606 GN=NUP37 PE=1 SV=1" "0.000" "False" "7.813" "8" "3" "3" "3" "326" "36.7" "5.92" "8.63" "3" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "79023" "ENSG00000075188" "NUP37" "hsa:79023; Q8NFH4; Q9H644" "" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; Transport of Mature mRNA derived from an Intron-Containing Transcript; tRNA processing in the nucleus; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "35" "0" "1.009" "1.091" "1.066" "1.112" "1.011" "1.170" "1.036" "1.070" "0.993" "168.9" "170.4" "184.2" "180.1" "187.7" "170.7" "197.6" "175.0" "180.6" "167.6" "" "" "" "" "" "" "" "" "" "" "158.2" "141.0" "171.0" "139.2" "160.0" "163.1" "180.5" "155.4" "180.6" "161.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2488299377452803712" "False" "High" "IsMasterProtein" "Q8N9T8" "Protein KRI1 homolog OS=Homo sapiens OX=9606 GN=KRI1 PE=1 SV=3" "0.000" "False" "7.811" "5" "2" "2" "2" "703" "82.5" "5.14" "8.15" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf05178, Pf12936" "65095" "ENSG00000129347" "KRI1" "hsa:65095; Q2M1R5; Q2M1R7; Q7L5J7; Q8N9T8; Q96G92; Q9BU50; Q9H6I1; Q9H978" "" "" "0" "0" "1.147" "1.091" "1.381" "1.235" "1.172" "1.433" "1.500" "1.380" "1.379" "223.9" "256.8" "244.4" "309.2" "276.4" "262.3" "320.8" "335.9" "308.8" "308.7" "" "" "" "" "" "" "" "" "" "" "209.8" "212.5" "226.9" "239.0" "235.6" "250.6" "293.1" "298.2" "308.8" "297.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8795922102085507366" "False" "High" "IsMasterProtein" "Q9ULM3" "YEATS domain-containing protein 2 OS=Homo sapiens OX=9606 GN=YEATS2 PE=1 SV=2" "0.000" "False" "7.800" "2" "4" "4" "3" "1422" "150.7" "8.98" "8.14" "4" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03366" "55689" "ENSG00000163872" "YEATS2" "A7E2B9; D3DNS9; hsa:55689; Q641P6; Q9NW96; Q9ULM3" "" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "2" "0" "1.483" "1.018" "1.183" "1.154" "1.258" "1.107" "1.058" "1.142" "1.168" "302.9" "449.1" "308.4" "358.2" "349.7" "381.0" "335.4" "320.3" "345.9" "353.9" "" "" "" "" "" "" "" "" "" "" "283.8" "371.6" "286.3" "276.9" "298.1" "364.0" "306.5" "284.4" "345.9" "340.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9084397244840994227" "False" "High" "IsMasterProtein" "Q8N9B5" "Junction-mediating and -regulatory protein OS=Homo sapiens OX=9606 GN=JMY PE=1 SV=2" "0.000" "False" "7.786" "4" "3" "3" "3" "988" "111.4" "6.18" "8.85" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf15871, Pf15920" "133746" "ENSG00000152409" "JMY" "A1L4P5; B5MDS2; B5MDT0; hsa:133746; Q8N9B5" "" "Regulation of TP53 Activity through Methylation" "1" "0" "0.993" "1.016" "1.148" "1.001" "1.030" "1.000" "0.975" "0.919" "0.999" "244.2" "242.3" "247.9" "280.2" "244.5" "251.4" "244.2" "238.0" "224.3" "243.9" "" "" "" "" "" "" "" "" "" "" "228.8" "200.5" "230.2" "216.6" "208.4" "240.2" "223.1" "211.3" "224.3" "234.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3901597498303011274" "False" "High" "IsMasterProtein" "P14621" "Acylphosphatase-2 OS=Homo sapiens OX=9606 GN=ACYP2 PE=1 SV=2" "0.000" "False" "7.783" "24" "3" "4" "3" "99" "11.1" "9.50" "11.98" "3" "other metabolic processes" "" "other molecular function" "Pf00708" "98" "ENSG00000170634" "ACYP2" "hsa:98; P14621" "" "" "0" "0" "0.967" "0.968" "0.990" "1.014" "0.985" "0.949" "1.015" "0.954" "1.020" "868.6" "839.7" "841.0" "859.7" "880.5" "855.3" "824.7" "881.6" "828.6" "886.2" "" "" "" "" "" "" "" "" "" "" "813.9" "694.9" "780.8" "664.6" "750.5" "817.2" "753.6" "782.8" "828.6" "853.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5712517081782202986" "False" "High" "IsMasterProtein" "Q86V48" "Leucine zipper protein 1 OS=Homo sapiens OX=9606 GN=LUZP1 PE=1 SV=2" "0.000" "False" "7.769" "3" "4" "4" "4" "1076" "120.2" "8.50" "11.27" "4" "developmental processes" "cytoskeleton;nucleus;other cell component" "" "" "7798" "ENSG00000169641" "LUZP1" "hsa:7798; Q5TH93; Q86V48; Q8N4X3; Q8TEH1" "Orexin receptor pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8609206004865475892" "False" "High" "IsMasterProtein" "Q96BD8" "Spindle and kinetochore-associated protein 1 OS=Homo sapiens OX=9606 GN=SKA1 PE=1 SV=1" "0.000" "False" "7.768" "11" "4" "5" "4" "255" "29.5" "7.12" "11.34" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf07160" "220134" "ENSG00000154839; ENSG00000262634" "SKA1" "B2R9Y6; B4E0P4; hsa:220134; Q96BD8" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.979" "1.006" "1.025" "1.075" "1.102" "0.969" "0.994" "0.936" "1.104" "1510.5" "1478.7" "1519.5" "1548.3" "1624.4" "1664.9" "1464.3" "1500.9" "1414.4" "1667.1" "" "" "" "" "" "" "" "" "" "" "1415.3" "1223.6" "1410.6" "1196.9" "1384.6" "1590.6" "1338.0" "1332.6" "1414.4" "1605.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-379596745727063060" "False" "High" "IsMasterProtein" "Q96CW6" "Probable RNA polymerase II nuclear localization protein SLC7A6OS OS=Homo sapiens OX=9606 GN=SLC7A6OS PE=1 SV=2" "0.000" "False" "7.760" "7" "2" "2" "2" "309" "35.0" "4.60" "8.98" "2" "transport;other biological processes" "nucleus;other cell component" "" "Pf08574" "84138" "ENSG00000103061" "SLC7A6OS" "hsa:84138; Q8TCZ3; Q96CW6; Q9H8R8" "" "" "0" "0" "1.041" "0.984" "1.038" "1.112" "0.989" "0.902" "0.930" "0.942" "0.992" "399.3" "415.5" "393.0" "414.4" "444.1" "395.0" "360.4" "371.4" "376.3" "396.3" "" "" "" "" "" "" "" "" "" "" "374.2" "343.9" "364.8" "320.4" "378.6" "377.3" "329.3" "329.8" "376.3" "381.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2260293505055803748" "False" "High" "IsMasterProtein" "Q5JSZ5" "Protein PRRC2B OS=Homo sapiens OX=9606 GN=PRRC2B PE=1 SV=2" "0.000" "False" "7.756" "1" "3" "3" "2" "2229" "242.8" "8.34" "8.47" "3" "other biological processes" "" "" "Pf07001" "84726" "ENSG00000288701" "PRRC2B" "hsa:84726; O60270; Q5JSZ5; Q5JSZ7; Q66VZ2; Q68CR0; Q96EI9; Q9H683" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "710012249327667382" "False" "High" "IsMasterProtein" "P48449" "Lanosterol synthase OS=Homo sapiens OX=9606 GN=LSS PE=1 SV=1" "0.000" "False" "7.754" "5" "4" "4" "4" "732" "83.3" "6.61" "6.92" "4" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00432" "4047" "ENSG00000160285" "LSS" "B4DJZ9; D3DSN0; E9PEI9; G5E9Q9; P48449; Q8IYL6; Q9UEZ1" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "8" "0" "0.940" "1.007" "1.060" "0.991" "0.984" "1.050" "1.019" "0.994" "0.994" "484.2" "455.2" "487.6" "513.2" "480.1" "476.6" "508.5" "493.5" "481.3" "481.2" "" "" "" "" "" "" "" "" "" "" "453.7" "376.7" "452.7" "396.7" "409.2" "455.4" "464.6" "438.2" "481.3" "463.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5815959030617886930" "False" "High" "IsMasterProtein" "O75167" "Phosphatase and actin regulator 2 OS=Homo sapiens OX=9606 GN=PHACTR2 PE=1 SV=2" "0.000" "False" "7.743" "4" "2" "2" "2" "634" "69.7" "8.16" "10.07" "2" "cell organization and biogenesis" "plasma membrane;other membranes" "enzyme regulator activity;cytoskeletal activity" "Pf02755" "9749" "ENSG00000112419" "PHACTR2" "A6NKP5; A7MCZ5; A8MZC0; B2RWP7; B4DN76; B4DPB5; B4DTH7; hsa:9749; O75167; Q5TFA0; Q68DM2" "" "Platelet degranulation" "1" "0" "1.154" "1.169" "1.125" "1.204" "1.120" "1.157" "1.157" "1.088" "1.146" "293.8" "339.2" "343.4" "330.6" "353.7" "329.1" "340.0" "340.0" "319.8" "336.7" "" "" "" "" "" "" "" "" "" "" "275.3" "280.7" "318.8" "255.6" "301.5" "314.4" "310.7" "301.9" "319.8" "324.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7546150518504420539" "False" "High" "IsMasterProtein" "O00186" "Syntaxin-binding protein 3 OS=Homo sapiens OX=9606 GN=STXBP3 PE=1 SV=2" "0.000" "False" "7.738" "4" "3" "3" "3" "592" "67.7" "7.80" "9.90" "3" "cell adhesion;cell-cell signaling;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00995" "6814" "ENSG00000116266" "STXBP3" "A8K269; A8K5K7; hsa:6814; O00186; Q53FW1; Q86YJ3; Q9UPD7" "Insulin signaling" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Disinhibition of SNARE formation" "3" "0" "1.057" "1.061" "1.024" "1.051" "1.057" "0.993" "0.958" "1.001" "1.089" "397.4" "420.0" "421.6" "407.1" "417.6" "419.9" "394.6" "380.7" "397.7" "432.9" "" "" "" "" "" "" "" "" "" "" "372.3" "347.6" "391.4" "314.7" "356.0" "401.2" "360.5" "338.0" "397.7" "416.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3242855938982215798" "False" "High" "IsMasterProtein" "Q9BQP7" "Mitochondrial genome maintenance exonuclease 1 OS=Homo sapiens OX=9606 GN=MGME1 PE=1 SV=1" "0.000" "False" "7.736" "8" "3" "3" "3" "344" "39.4" "7.68" "9.07" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "mitochondrion" "other molecular function" "Pf12705" "92667" "ENSG00000125871" "MGME1" "B2RDG5; D3DW29; hsa:92667; Q96SW3; Q9BQP7" "Primary ovarian insufficiency" "" "1" "0" "0.967" "1.036" "0.934" "0.961" "0.983" "0.927" "0.928" "0.999" "1.019" "812.6" "785.9" "842.2" "759.1" "780.9" "798.8" "753.2" "754.1" "812.0" "827.9" "" "" "" "" "" "" "" "" "" "" "761.4" "650.3" "781.9" "586.8" "665.6" "763.1" "688.3" "669.6" "812.0" "797.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7756363839167913105" "False" "High" "IsMasterProtein" "Q13490" "Baculoviral IAP repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=BIRC2 PE=1 SV=2" "0.000" "False" "7.718" "5" "3" "3" "3" "618" "69.9" "6.70" "5.39" "3" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf00653, Pf13920, Pf21290" "329" "ENSG00000110330" "BIRC2" "B4E026; hsa:329; Q13490; Q16516; Q4TTG0" "TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; TNF-alpha signaling pathway; Apoptosis; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Focal adhesion; Photodynamic therapy-induced NF-kB survival signaling; Small cell lung cancer; Gastrin signaling pathway; Head and neck squamous cell carcinoma" "Ub-specific processing proteases; IKK complex recruitment mediated by RIP1; Regulation of necroptotic cell death; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling; Apoptotic cleavage of cellular proteins" "22" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7950271419257628424" "False" "High" "IsMasterProtein" "P30049" "ATP synthase subunit delta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1D PE=1 SV=2" "0.000" "False" "7.706" "14" "2" "2" "2" "168" "17.5" "5.49" "9.76" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf02823, Pf21335" "513" "ENSG00000099624" "ATP5F1D" "D6W5Y3; hsa:513; P30049; Q6FG90" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Cristae formation; Formation of ATP by chemiosmotic coupling" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2849598886551382800" "False" "High" "IsMasterProtein" "Q9P2K5" "Myelin expression factor 2 OS=Homo sapiens OX=9606 GN=MYEF2 PE=1 SV=3" "0.000" "False" "7.706" "5" "3" "3" "3" "600" "64.1" "8.75" "6.35" "3" "developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076" "50804" "ENSG00000104177" "MYEF2" "A7MCZ9; C9J921; C9K0J4; hsa:50804; Q6NUM5; Q7L388; Q7Z4B7; Q9H922; Q9NUQ1; Q9P2K5" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Mitochondrial gene expression" "" "4" "0" "1.092" "1.039" "0.909" "0.996" "1.073" "1.056" "1.066" "1.074" "1.041" "139.7" "152.5" "145.2" "127.0" "139.2" "149.9" "147.5" "148.9" "150.0" "145.5" "" "" "" "" "" "" "" "" "" "" "130.9" "126.2" "134.8" "98.2" "118.7" "143.3" "134.8" "132.2" "150.0" "140.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8872418037025781977" "False" "High" "IsMasterProtein" "Q5VTB9" "E3 ubiquitin-protein ligase RNF220 OS=Homo sapiens OX=9606 GN=RNF220 PE=1 SV=1" "0.000" "False" "7.704" "4" "2" "2" "2" "566" "62.7" "6.04" "7.24" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13923, Pf15926" "55182" "ENSG00000187147" "RNF220" "B3KPJ3; B4DLZ9; E9PCS1; hsa:55182; Q4KMX2; Q5VTB9; Q9NVP6" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.078" "1.085" "1.160" "1.112" "1.048" "1.093" "1.116" "1.023" "1.112" "311.4" "335.6" "337.7" "361.1" "346.3" "326.4" "340.5" "347.7" "318.5" "346.3" "" "" "" "" "" "" "" "" "" "" "291.8" "277.7" "313.5" "279.1" "295.2" "311.8" "311.1" "308.7" "318.5" "333.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6537965283186170392" "False" "High" "IsMasterProtein" "Q9UM13" "Anaphase-promoting complex subunit 10 OS=Homo sapiens OX=9606 GN=ANAPC10 PE=1 SV=1" "0.000" "False" "7.700" "18" "3" "3" "3" "185" "21.2" "9.06" "8.45" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf03256" "10393" "ENSG00000164162" "ANAPC10" "D3DNZ7; hsa:10393; Q2V500; Q9UG51; Q9UM13; Q9Y5R0" "Cell cycle" "Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "0.948" "0.975" "0.946" "0.918" "1.047" "0.874" "0.897" "1.080" "1.043" "237.8" "225.5" "231.9" "224.9" "218.4" "249.1" "207.9" "213.4" "256.8" "248.1" "" "" "" "" "" "" "" "" "" "" "222.9" "186.6" "215.3" "173.8" "186.2" "237.9" "190.0" "189.4" "256.8" "238.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4577230366185343110" "False" "High" "IsMasterProtein" "Q96GM8" "Target of EGR1 protein 1 OS=Homo sapiens OX=9606 GN=TOE1 PE=1 SV=1" "0.000" "False" "7.698" "5" "3" "4" "3" "510" "56.5" "7.18" "12.39" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf04857" "114034" "ENSG00000132773" "TOE1" "B4DEM6; hsa:114034; Q6IA35; Q8IWN5; Q96GM8; Q9H846" "" "" "0" "0" "0.886" "0.981" "0.845" "0.891" "1.014" "1.031" "0.871" "0.967" "1.007" "75.9" "67.2" "74.4" "64.1" "67.6" "77.0" "78.2" "66.1" "73.3" "76.4" "" "" "" "" "" "" "" "" "" "" "71.1" "55.6" "69.1" "49.6" "57.6" "73.5" "71.4" "58.7" "73.3" "73.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1391272447933749932" "False" "High" "IsMasterProtein" "Q9UNI6" "Dual specificity protein phosphatase 12 OS=Homo sapiens OX=9606 GN=DUSP12 PE=1 SV=1" "0.000" "False" "7.694" "8" "3" "3" "3" "340" "37.7" "6.84" "6.67" "3" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00782" "11266" "ENSG00000081721" "DUSP12" "hsa:11266; Q5VXA8; Q9UNI6" "" "" "0" "0" "0.953" "1.027" "1.043" "0.998" "0.998" "0.989" "1.059" "0.997" "0.971" "635.7" "605.7" "653.0" "662.8" "634.6" "634.8" "628.8" "673.3" "633.9" "617.0" "" "" "" "" "" "" "" "" "" "" "595.7" "501.2" "606.2" "512.4" "540.9" "606.5" "574.6" "597.8" "633.9" "594.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5048841209035306562" "False" "High" "IsMasterProtein" "Q9H845" "Complex I assembly factor ACAD9, mitochondrial OS=Homo sapiens OX=9606 GN=ACAD9 PE=1 SV=1" "0.000" "False" "7.684" "4" "3" "3" "3" "621" "68.7" "7.96" "9.36" "3" "cell organization and biogenesis;other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00441, Pf02770, Pf02771, Pf21343" "28976" "ENSG00000177646" "ACAD9" "D3DNB8; hsa:28976; Q8WXX3; Q9H845" "Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "Complex I biogenesis" "3" "0" "1.032" "1.017" "1.131" "1.029" "1.039" "1.124" "1.010" "1.017" "1.006" "390.2" "402.7" "396.7" "441.3" "401.5" "405.4" "438.8" "394.0" "397.0" "392.4" "" "" "" "" "" "" "" "" "" "" "365.7" "333.2" "368.3" "341.1" "342.2" "387.3" "400.9" "349.8" "397.0" "377.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3318152306764108447" "False" "High" "IsMasterProtein" "O60563" "Cyclin-T1 OS=Homo sapiens OX=9606 GN=CCNT1 PE=1 SV=1" "0.000" "False" "7.679" "3" "3" "3" "3" "726" "80.6" "8.78" "9.16" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00134, Pf21797" "904" "ENSG00000129315" "CCNT1" "A9XU13; E7EX76; hsa:904; O60563; O60581" "Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins" "17" "0" "1.061" "1.100" "1.102" "1.118" "1.099" "1.225" "1.356" "1.202" "1.122" "474.7" "503.6" "522.4" "523.4" "530.9" "521.6" "581.3" "643.5" "570.8" "532.8" "" "" "" "" "" "" "" "" "" "" "444.8" "416.7" "485.0" "404.6" "452.5" "498.3" "531.2" "571.4" "570.8" "513.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "514790625548438605" "False" "High" "IsMasterProtein" "Q8WUX2" "Glutathione-specific gamma-glutamylcyclotransferase 2 OS=Homo sapiens OX=9606 GN=CHAC2 PE=1 SV=1" "0.000" "False" "7.677" "18" "3" "4" "3" "184" "20.9" "5.43" "12.95" "3" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf04752" "494143" "ENSG00000143942" "CHAC2" "hsa:494143; Q8WUX2; Q8WVI8" "" "Glutathione synthesis and recycling" "1" "0" "0.966" "0.935" "0.957" "0.976" "1.028" "0.893" "0.927" "0.945" "0.950" "580.6" "560.7" "542.8" "555.8" "566.8" "596.9" "518.4" "538.3" "548.7" "551.9" "" "" "" "" "" "" "" "" "" "" "544.0" "464.0" "503.9" "429.7" "483.1" "570.3" "473.7" "478.0" "548.7" "531.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2101401554741180333" "False" "High" "IsMasterProtein" "Q8N5M1" "ATP synthase mitochondrial F1 complex assembly factor 2 OS=Homo sapiens OX=9606 GN=ATPAF2 PE=1 SV=1" "0.000" "False" "7.669" "8" "2" "2" "2" "289" "32.8" "7.09" "7.45" "2" "cell organization and biogenesis" "cytosol;mitochondrion;nucleus" "" "Pf07542" "91647" "ENSG00000171953" "ATPAF2" "A6NDE5; A8K2J2; hsa:91647; Q6XYC7; Q8N5M1" "7q11.23 copy number variation syndrome; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8494300980345175756" "False" "High" "IsMasterProtein" "P48059" "LIM and senescent cell antigen-like-containing domain protein 1 OS=Homo sapiens OX=9606 GN=LIMS1 PE=1 SV=4" "0.000" "False" "7.666" "8" "3" "3" "3" "325" "37.2" "8.05" "5.74" "3" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00412" "3987" "ENSG00000169756" "LIMS1" "B2RAJ4; B7Z483; B7Z7R3; B7Z907; hsa:3987; P48059; Q53TE0; Q9BS44" "Primary focal segmental glomerulosclerosis (FSGS)" "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "3" "0" "1.065" "0.972" "1.010" "1.055" "1.016" "1.004" "0.966" "1.006" "1.056" "348.4" "371.0" "338.5" "351.9" "367.5" "354.0" "349.9" "336.5" "350.5" "368.0" "" "" "" "" "" "" "" "" "" "" "326.4" "307.0" "314.3" "272.0" "313.2" "338.2" "319.7" "298.8" "350.5" "354.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8443546389451323737" "False" "High" "IsMasterProtein" "Q96HJ9" "Protein FMC1 homolog OS=Homo sapiens OX=9606 GN=FMC1 PE=1 SV=2" "0.000" "False" "7.660" "11" "1" "2" "1" "113" "12.7" "10.07" "8.91" "1" "cell organization and biogenesis;other biological processes" "mitochondrion" "" "Pf13233" "100996928; 154791" "ENSG00000164898" "FMC1" "B7Z4Q3; hsa:100996928; hsa:154791; Q75M90; Q96HJ9; Q9P0B3" "" "" "0" "0" "0.968" "0.979" "0.974" "1.054" "1.033" "0.998" "1.057" "1.020" "1.031" "446.7" "432.3" "437.2" "435.2" "470.8" "461.4" "445.7" "472.0" "455.4" "460.5" "" "" "" "" "" "" "" "" "" "" "418.6" "357.7" "405.9" "336.5" "401.3" "440.8" "407.2" "419.1" "455.4" "443.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-397251386471415027" "False" "High" "IsMasterProtein" "Q9Y3X0" "Coiled-coil domain-containing protein 9 OS=Homo sapiens OX=9606 GN=CCDC9 PE=1 SV=1" "0.000" "False" "7.644" "5" "3" "3" "3" "531" "59.7" "5.40" "6.73" "3" "" "nucleus" "nucleic acid binding activity" "Pf15266" "26093" "ENSG00000105321" "CCDC9" "hsa:26093; Q9Y3X0" "IL-18 signaling pathway" "" "1" "0" "1.063" "1.042" "0.945" "0.981" "1.107" "0.940" "0.948" "0.932" "0.984" "321.7" "341.8" "335.1" "303.8" "315.6" "356.2" "302.4" "304.9" "299.8" "316.5" "" "" "" "" "" "" "" "" "" "" "301.4" "282.8" "311.1" "234.9" "269.0" "340.3" "276.4" "270.7" "299.8" "304.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5049271637643204736" "False" "High" "IsMasterProtein" "Q96F63" "Coiled-coil domain-containing protein 97 OS=Homo sapiens OX=9606 GN=CCDC97 PE=1 SV=1" "0.000" "False" "7.642" "11" "2" "2" "2" "343" "38.9" "4.59" "7.33" "2" "" "nucleus" "" "Pf09747" "90324" "ENSG00000142039" "CCDC97" "hsa:90324; Q658N6; Q96F63; Q96IF3" "" "" "0" "0" "1.147" "1.091" "1.042" "1.083" "1.204" "0.972" "0.990" "1.059" "1.163" "146.0" "167.5" "159.2" "152.1" "158.1" "175.7" "141.8" "144.5" "154.6" "169.7" "" "" "" "" "" "" "" "" "" "" "136.8" "138.6" "147.8" "117.6" "134.7" "167.9" "129.6" "128.3" "154.6" "163.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6769080269671987288" "False" "High" "IsMasterProtein" "Q9NVP1" "ATP-dependent RNA helicase DDX18 OS=Homo sapiens OX=9606 GN=DDX18 PE=1 SV=2" "0.000" "False" "7.641" "5" "3" "3" "3" "670" "75.4" "9.50" "9.37" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf13959" "8886" "ENSG00000088205" "DDX18" "hsa:8886; Q6GTZ9; Q6IAU4; Q92732; Q9BQB7; Q9NVP1" "" "" "0" "0" "1.102" "0.947" "1.004" "1.035" "1.037" "1.217" "1.228" "1.259" "1.114" "443.5" "488.5" "420.1" "445.2" "459.1" "459.7" "539.5" "544.4" "558.2" "493.9" "" "" "" "" "" "" "" "" "" "" "415.5" "404.3" "390.0" "344.2" "391.3" "439.2" "493.0" "483.4" "558.2" "475.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1962544655148758053" "False" "High" "IsMasterProtein" "P35240" "Merlin OS=Homo sapiens OX=9606 GN=NF2 PE=1 SV=1" "0.000" "False" "7.640" "4" "3" "3" "2" "595" "69.6" "6.47" "9.97" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "4771" "ENSG00000186575" "NF2" "hsa:4771; O95683; P35240; Q8WUJ2; Q969N0; Q969Q3; Q96T30; Q96T31; Q96T32; Q96T33; Q9BTW3; Q9UNG9; Q9UNH3; Q9UNH4" "Ectoderm differentiation; Ectoderm differentiation; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; 3q29 copy number variation syndrome; Pleural mesothelioma" "Regulation of actin dynamics for phagocytic cup formation; RHO GTPases activate PAKs" "10" "1" "0.994" "1.018" "1.066" "1.120" "1.085" "0.999" "1.033" "0.999" "1.051" "393.7" "391.3" "401.0" "419.7" "441.2" "427.1" "393.4" "406.6" "393.2" "413.7" "" "" "" "" "" "" "" "" "" "" "368.9" "323.8" "372.3" "324.5" "376.0" "408.1" "359.5" "361.0" "393.2" "398.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7841713393868884800" "False" "High" "IsMasterProtein" "Q9BSL1" "Ubiquitin-associated domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBAC1 PE=1 SV=1" "0.000" "False" "7.638" "8" "3" "4" "3" "405" "45.3" "4.92" "10.59" "3" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00627" "10422" "ENSG00000130560" "UBAC1" "hsa:10422; O75500; Q9BSL1; Q9UMW7" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.916" "0.954" "1.040" "1.021" "0.978" "1.065" "1.002" "0.924" "0.988" "683.7" "626.2" "652.6" "711.4" "697.9" "669.0" "728.3" "684.9" "631.8" "675.7" "" "" "" "" "" "" "" "" "" "" "640.6" "518.2" "605.8" "549.9" "594.9" "639.1" "665.5" "608.1" "631.8" "650.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7973916192928746401" "False" "High" "IsMasterProtein" "Q8N6N7" "Acyl-CoA-binding domain-containing protein 7 OS=Homo sapiens OX=9606 GN=ACBD7 PE=1 SV=1" "0.000" "False" "7.632" "26" "2" "2" "2" "88" "9.8" "6.71" "8.29" "2" "other metabolic processes" "" "other molecular function" "Pf00887" "414149" "ENSG00000176244" "ACBD7" "A6NCI2; B3KTG8; hsa:414149; Q8N6N7" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "1.095" "1.022" "1.045" "1.073" "1.070" "0.937" "1.023" "0.986" "1.085" "416.2" "455.7" "425.2" "434.9" "446.4" "445.4" "390.2" "426.0" "410.4" "451.6" "" "" "" "" "" "" "" "" "" "" "390.0" "377.1" "394.8" "336.2" "380.5" "425.6" "356.6" "378.2" "410.4" "434.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8740975055967109676" "False" "High" "IsMasterProtein" "O95926" "Pre-mRNA-splicing factor SYF2 OS=Homo sapiens OX=9606 GN=SYF2 PE=1 SV=1" "0.000" "False" "7.630" "9" "2" "2" "2" "243" "28.7" "8.40" "7.78" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf08231" "25949" "ENSG00000117614" "SYF2" "hsa:25949; O95926; Q5TH73" "" "mRNA Splicing - Major Pathway" "1" "0" "1.031" "0.893" "0.930" "0.987" "0.927" "1.064" "1.030" "0.948" "0.990" "271.9" "280.3" "242.7" "252.9" "268.3" "252.0" "289.4" "280.1" "257.8" "269.2" "" "" "" "" "" "" "" "" "" "" "254.8" "231.9" "225.4" "195.5" "228.7" "240.8" "264.4" "248.7" "257.8" "259.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6665456693960719485" "False" "High" "IsMasterProtein" "Q86V88" "Magnesium-dependent phosphatase 1 OS=Homo sapiens OX=9606 GN=MDP1 PE=1 SV=1" "0.000" "False" "7.624" "20" "3" "3" "3" "176" "20.1" "6.39" "7.14" "3" "" "" "other molecular function" "Pf12689" "145553" "ENSG00000213920; ENSG00000285200" "MDP1" "hsa:145553; Q86V88; Q86Y84; Q8NAD9" "" "" "0" "0" "1.025" "0.994" "1.083" "0.977" "1.026" "0.936" "0.975" "1.034" "1.027" "239.7" "245.7" "238.2" "259.7" "234.1" "245.9" "224.3" "233.7" "247.9" "246.1" "" "" "" "" "" "" "" "" "" "" "224.6" "203.3" "221.1" "200.8" "199.6" "234.9" "205.0" "207.5" "247.9" "237.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4879216047058048587" "False" "High" "IsMasterProtein" "P81605" "Dermcidin OS=Homo sapiens OX=9606 GN=DCD PE=1 SV=2" "0.000" "False" "7.618" "22" "3" "3" "3" "110" "11.3" "6.54" "5.71" "3" "protein metabolism;stress response;transport" "non-structural extracellular;other membranes" "transporter activity;other molecular function" "Pf15291" "117159" "ENSG00000161634" "DCD" "A5JHP2; A5JHP3; hsa:117159; P58461; P81605; Q53YJ2" "" "Antimicrobial peptides" "1" "0" "0.403" "0.337" "0.465" "0.463" "0.388" "1.287" "0.576" "0.465" "0.509" "1026.2" "413.5" "346.0" "477.1" "475.0" "398.3" "1321.0" "590.8" "476.8" "522.4" "" "" "" "" "" "" "" "" "" "" "961.5" "342.1" "321.2" "368.8" "404.9" "380.5" "1207.1" "524.6" "476.8" "503.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4612502200950371664" "False" "High" "IsMasterProtein" "Q86V21" "Acetoacetyl-CoA synthetase OS=Homo sapiens OX=9606 GN=AACS PE=1 SV=1" "0.000" "False" "7.604" "4" "2" "2" "2" "672" "75.1" "6.24" "9.59" "2" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00501, Pf16177" "65985" "ENSG00000081760" "AACS" "hsa:65985; Q49AB9; Q49AC3; Q658Q8; Q86V21; Q8IWD2; Q8NEW5; Q9BSJ9; Q9H829; Q9HA19" "" "Synthesis of Ketone Bodies" "1" "0" "0.976" "1.036" "1.014" "0.995" "1.081" "0.987" "1.009" "0.993" "1.099" "365.3" "356.4" "378.5" "370.5" "363.3" "395.0" "360.4" "368.7" "362.7" "401.5" "" "" "" "" "" "" "" "" "" "" "342.3" "294.9" "351.4" "286.4" "309.7" "377.4" "329.3" "327.4" "362.7" "386.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2198906581928094734" "False" "High" "IsMasterProtein" "Q9BQC3" "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 OS=Homo sapiens OX=9606 GN=DPH2 PE=1 SV=1" "0.000" "False" "7.603" "6" "3" "3" "3" "489" "52.1" "5.53" "9.95" "3" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01866" "1802" "ENSG00000132768" "DPH2" "A8MVC9; B2RDE3; B4DNI8; hsa:1802; O60623; Q9BQC3" "" "Synthesis of diphthamide-EEF2" "1" "0" "0.984" "0.962" "0.996" "0.981" "1.033" "0.987" "0.899" "0.946" "0.998" "617.1" "607.4" "593.5" "614.6" "605.2" "637.8" "608.9" "554.6" "583.8" "615.8" "" "" "" "" "" "" "" "" "" "" "578.3" "502.6" "551.0" "475.1" "515.9" "609.3" "556.4" "492.4" "583.8" "592.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4465081379876381336" "False" "High" "IsMasterProtein" "Q86U70" "LIM domain-binding protein 1 OS=Homo sapiens OX=9606 GN=LDB1 PE=1 SV=2" "0.000" "False" "7.601" "9" "4" "4" "4" "411" "46.5" "6.96" "7.48" "4" "cell adhesion;cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01803, Pf17916" "8861" "ENSG00000198728" "LDB1" "B4DUC4; hsa:8861; O75479; O96010; Q1EQX1; Q86U70; Q9UGM4" "" "Regulation of expression of SLITs and ROBOs; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Expression and translocation of olfactory receptors; Cardiogenesis" "4" "0" "0.903" "0.992" "1.019" "1.005" "0.950" "0.981" "0.968" "0.969" "1.009" "437.5" "395.0" "434.1" "445.8" "439.6" "415.6" "429.4" "423.7" "423.9" "441.6" "" "" "" "" "" "" "" "" "" "" "410.0" "326.8" "403.0" "344.6" "374.7" "397.0" "392.4" "376.2" "423.9" "425.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7820090330366172225" "False" "High" "IsMasterProtein" "Cont_Q7RTS7" "Keratin, type II cytoskeletal 74 OS=Homo sapiens OX=9606 GN=KRT74 PE=1 SV=2" "0.000" "True" "7.598" "5" "3" "5" "1" "529" "57.8" "7.71" "10.89" "3" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038, Pf16208" "121391" "ENSG00000170484" "KRT74" "B5MD61; hsa:121391; Q7RTS7; Q86Y45" "" "Formation of the cornified envelope" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8165152486354207968" "False" "High" "IsMasterProtein" "O75037" "Kinesin-like protein KIF21B OS=Homo sapiens OX=9606 GN=KIF21B PE=1 SV=2" "0.000" "False" "7.594" "2" "4" "4" "1" "1637" "182.5" "7.08" "7.81" "4" "other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf00400" "23046" "ENSG00000116852" "KIF21B" "B2RP62; B7ZMI0; hsa:23046; O75037; Q5T4J3" "" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3039666916282587145" "False" "High" "IsMasterProtein" "Q562E7" "WD repeat-containing protein 81 OS=Homo sapiens OX=9606 GN=WDR81 PE=1 SV=2" "0.000" "False" "7.592" "3" "4" "4" "4" "1941" "211.6" "5.58" "9.72" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;mitochondrion;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00400, Pf02138" "124997" "ENSG00000167716; ENSG00000276021" "WDR81" "B3KW16; B3KXU1; B7Z579; E9PHG7; hsa:124997; Q24JP6; Q562E7; Q8N277; Q8N3F3; Q8TEL1" "" "CDC42 GTPase cycle" "1" "0" "1.012" "0.970" "1.124" "0.958" "0.969" "1.081" "1.025" "0.952" "0.990" "180.7" "182.8" "175.2" "203.1" "173.2" "175.1" "195.2" "185.2" "172.0" "178.8" "" "" "" "" "" "" "" "" "" "" "169.3" "151.2" "162.7" "157.0" "147.6" "167.3" "178.4" "164.5" "172.0" "172.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4201760533929060036" "False" "High" "IsMasterProtein" "P63313" "Thymosin beta-10 OS=Homo sapiens OX=9606 GN=TMSB10 PE=1 SV=2" "0.000" "False" "7.590" "34" "3" "13" "3" "44" "5.0" "5.36" "41.83" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf01290" "9168" "ENSG00000034510" "TMSB10" "hsa:9168; P13472; P63313; Q596K9" "VEGFA-VEGFR2 signaling; Extrafollicular and follicular B cell activation by SARS-CoV-2" "" "2" "0" "1.622" "1.063" "1.409" "0.982" "2.602" "0.838" "1.014" "1.286" "1.641" "1152.7" "1870.3" "1225.6" "1623.9" "1132.5" "2999.8" "966.2" "1169.3" "1482.9" "1892.2" "" "" "" "" "" "" "" "" "" "" "1080.1" "1547.6" "1137.8" "1255.4" "965.3" "2866.1" "882.9" "1038.2" "1482.9" "1821.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "592112739915171791" "False" "High" "IsMasterProtein" "Q8NCG7" "Diacylglycerol lipase-beta OS=Homo sapiens OX=9606 GN=DAGLB PE=1 SV=2" "0.000" "False" "7.583" "4" "3" "3" "3" "672" "73.7" "6.55" "8.75" "3" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus" "other molecular function" "Pf01764" "221955" "ENSG00000164535" "DAGLB" "A4D2P3; B3KV90; B4DQU0; hsa:221955; Q6PIX3; Q8N2N2; Q8N9S1; Q8NCG7; Q8TED3; Q8WXE6" "Cannabinoid receptor signaling; ADHD and autism (ASD) linked metabolic pathways and SNP" "Arachidonate production from DAG" "3" "0" "0.914" "0.887" "0.964" "1.031" "1.008" "0.947" "1.019" "0.951" "0.938" "318.5" "291.0" "282.4" "307.1" "328.3" "321.1" "301.7" "324.6" "302.9" "298.7" "" "" "" "" "" "" "" "" "" "" "298.4" "240.8" "262.2" "237.4" "279.8" "306.8" "275.7" "288.2" "302.9" "287.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1707111681236337832" "False" "High" "IsMasterProtein" "Q96BY7" "Autophagy-related protein 2 homolog B OS=Homo sapiens OX=9606 GN=ATG2B PE=1 SV=5" "0.000" "False" "7.582" "1" "3" "3" "3" "2078" "232.6" "5.76" "6.29" "3" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf09333, Pf12624, Pf13329" "55102" "ENSG00000066739" "ATG2B" "hsa:55102; Q6ZRE7; Q96BY7; Q96DQ3; Q9NW80" "Alzheimer's disease and miRNA effects; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Alzheimer's disease" "" "3" "0" "0.961" "1.128" "0.843" "1.032" "0.891" "0.791" "0.830" "0.845" "0.969" "56.1" "54.0" "63.3" "47.3" "57.9" "50.0" "44.4" "46.6" "47.5" "54.4" "" "" "" "" "" "" "" "" "" "" "52.6" "44.7" "58.8" "36.6" "49.4" "47.8" "40.6" "41.4" "47.5" "52.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-443661170883717287" "False" "High" "IsMasterProtein" "Q9NQ92" "Coordinator of PRMT5 and differentiation stimulator OS=Homo sapiens OX=9606 GN=COPRS PE=1 SV=3" "0.000" "False" "7.581" "18" "3" "3" "3" "184" "20.1" "4.18" "8.60" "3" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf15340" "55352" "ENSG00000172301" "COPRS" "A6NP14; E1P656; hsa:55352; Q96EF5; Q96P75; Q9NQ92" "NF1 copy number variation syndrome" "RMTs methylate histone arginines" "2" "0" "1.085" "0.986" "1.061" "1.043" "0.953" "0.999" "1.113" "1.025" "1.047" "263.8" "286.1" "260.0" "279.9" "275.2" "251.5" "263.5" "293.7" "270.4" "276.1" "" "" "" "" "" "" "" "" "" "" "247.1" "236.7" "241.4" "216.4" "234.5" "240.2" "240.8" "260.8" "270.4" "265.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5532821643516687408" "False" "High" "IsMasterProtein" "Q6P158" "Putative ATP-dependent RNA helicase DHX57 OS=Homo sapiens OX=9606 GN=DHX57 PE=1 SV=2" "0.000" "False" "7.576" "2" "3" "5" "2" "1386" "155.5" "7.71" "13.20" "3" "" "" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf05773, Pf07717, Pf18044, Pf21010" "90957" "ENSG00000163214" "DHX57" "A2RRC7; hsa:90957; Q53SI4; Q6P158; Q6P9G1; Q7Z6H3; Q8NG17; Q96M33" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3645624783218300571" "False" "High" "IsMasterProtein" "Q96CG3" "TRAF-interacting protein with FHA domain-containing protein A OS=Homo sapiens OX=9606 GN=TIFA PE=1 SV=1" "0.000" "False" "7.576" "13" "3" "4" "3" "184" "21.4" "5.11" "11.94" "3" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf00498" "92610" "ENSG00000145365" "TIFA" "hsa:92610; Q96CG3" "Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway" "TAK1-dependent IKK and NF-kappa-B activation ; Alpha-protein kinase 1 signaling pathway" "4" "0" "0.877" "0.959" "0.860" "0.822" "0.926" "0.821" "0.879" "0.834" "0.875" "1081.2" "948.6" "1036.6" "929.8" "889.2" "1001.6" "888.2" "949.9" "901.2" "945.7" "" "" "" "" "" "" "" "" "" "" "1013.1" "785.0" "962.4" "718.7" "757.9" "956.9" "811.5" "843.4" "901.2" "910.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1538396539459298741" "False" "High" "IsMasterProtein" "Q9H6Q4" "Cytosolic iron-sulfur assembly component 3 OS=Homo sapiens OX=9606 GN=CIAO3 PE=1 SV=1" "0.000" "False" "7.575" "7" "3" "3" "3" "476" "53.0" "7.23" "5.24" "3" "cell organization and biogenesis;stress response;other biological processes" "other cell component" "other molecular function" "Pf02256, Pf02906" "64428" "ENSG00000103245" "CIAO3" "A1L385; B3KTJ3; hsa:64428; Q53GC6; Q96S10; Q9H6J8; Q9H6Q4" "" "Cytosolic iron-sulfur cluster assembly" "1" "0" "1.033" "1.028" "0.903" "1.056" "1.019" "0.953" "1.049" "1.053" "1.017" "169.2" "174.9" "174.0" "152.8" "178.7" "172.5" "161.2" "177.4" "178.2" "172.2" "" "" "" "" "" "" "" "" "" "" "158.5" "144.7" "161.5" "118.1" "152.3" "164.8" "147.3" "157.5" "178.2" "165.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2602489287625283403" "False" "High" "IsMasterProtein" "P62330" "ADP-ribosylation factor 6 OS=Homo sapiens OX=9606 GN=ARF6 PE=1 SV=2" "0.000" "False" "7.573" "21" "3" "3" "3" "175" "20.1" "8.95" "8.56" "3" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00025" "382" "ENSG00000165527" "ARF6" "hsa:382; P26438; P62330; Q6FGZ2" "VEGFA-VEGFR2 signaling; Ras signaling; EGF/EGFR signaling pathway; IL-18 signaling pathway; Insulin signaling; CCL18 signaling pathway; 2q13 copy number variation syndrome" "Clathrin-mediated endocytosis; TBC/RABGAPs; MET receptor recycling" "10" "0" "1.042" "0.972" "1.115" "1.040" "1.065" "0.944" "0.963" "0.979" "1.068" "211.9" "220.9" "206.0" "236.3" "220.5" "225.6" "200.1" "204.1" "207.5" "226.3" "" "" "" "" "" "" "" "" "" "" "198.6" "182.8" "191.3" "182.7" "187.9" "215.6" "182.8" "181.2" "207.5" "217.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6395227692188504005" "False" "High" "IsMasterProtein" "Q7Z3K3" "Pogo transposable element with ZNF domain OS=Homo sapiens OX=9606 GN=POGZ PE=1 SV=2" "0.000" "False" "7.573" "2" "2" "2" "2" "1410" "155.2" "7.40" "8.21" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03184, Pf03221" "23126" "ENSG00000143442" "POGZ" "B4DTP8; B4DYL9; B7ZBY5; E9PM80; hsa:23126; O75049; Q3LIC4; Q5SZS1; Q5SZS2; Q5SZS3; Q5SZS4; Q7Z3K3; Q8TDZ7; Q9Y4X7" "" "" "0" "0" "0.982" "1.111" "1.196" "1.170" "1.067" "1.382" "1.409" "1.415" "1.213" "156.0" "153.3" "173.4" "186.6" "182.6" "166.5" "215.6" "219.9" "220.8" "189.3" "" "" "" "" "" "" "" "" "" "" "146.2" "126.8" "161.0" "144.2" "155.6" "159.1" "197.0" "195.3" "220.8" "182.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5166856508772248001" "False" "High" "IsMasterProtein" "P01111" "GTPase NRas OS=Homo sapiens OX=9606 GN=NRAS PE=1 SV=1" "0.000" "False" "7.572" "11" "2" "3" "1" "189" "21.2" "5.17" "12.67" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00071" "4893" "ENSG00000213281" "NRAS" "hsa:4893; P01111; Q14971; Q15104; Q15282" "Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; JAK-STAT signaling in the regulation of beta cells; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling" "FCERI mediated MAPK activation; Regulation of RAS by GAPs; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 in disease; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; Signaling by RAS GAP mutants; Signaling by RAS GTPase mutants" "110" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2928934229844812076" "False" "High" "IsMasterProtein" "Q8TCD5" "5'(3')-deoxyribonucleotidase, cytosolic type OS=Homo sapiens OX=9606 GN=NT5C PE=1 SV=2" "0.000" "False" "7.565" "16" "3" "3" "3" "201" "23.4" "6.64" "8.50" "3" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06941" "30833" "ENSG00000125458" "NT5C" "hsa:30833; Q8TCD5; Q96HS6; Q9NP82" "Pyrimidine metabolism" "Purine catabolism; Pyrimidine catabolism" "3" "0" "1.085" "1.138" "1.088" "1.094" "1.145" "1.119" "0.905" "0.868" "1.039" "93.5" "101.5" "106.5" "101.7" "102.3" "107.0" "104.7" "84.6" "81.2" "97.2" "" "" "" "" "" "" "" "" "" "" "87.6" "84.0" "98.8" "78.7" "87.2" "102.3" "95.6" "75.1" "81.2" "93.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8102518268723220557" "False" "High" "IsMasterProtein" "Q2M2I8" "AP2-associated protein kinase 1 OS=Homo sapiens OX=9606 GN=AAK1 PE=1 SV=3" "0.000" "False" "7.558" "2" "2" "2" "2" "961" "103.8" "6.60" "8.02" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069" "22848" "ENSG00000115977" "AAK1" "hsa:22848; Q2M2I8; Q4ZFZ3; Q53RX6; Q9UPV4" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "1.133" "1.107" "1.265" "1.146" "1.069" "1.154" "1.102" "1.058" "1.079" "401.0" "454.3" "444.0" "507.4" "459.5" "428.7" "462.6" "441.7" "424.2" "432.8" "" "" "" "" "" "" "" "" "" "" "375.7" "376.0" "412.2" "392.2" "391.7" "409.6" "422.7" "392.2" "424.2" "416.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3651526396460300245" "False" "High" "IsMasterProtein" "P17693" "HLA class I histocompatibility antigen, alpha chain G OS=Homo sapiens OX=9606 GN=HLA-G PE=1 SV=1" "0.000" "False" "7.546" "9" "3" "3" "1" "338" "38.2" "5.69" "8.64" "3" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "signal transduction activity or receptor binding;other molecular function" "Pf00129, Pf07654" "3135" "ENSG00000204632; ENSG00000206506; ENSG00000230413; ENSG00000233095; ENSG00000235346; ENSG00000235680; ENSG00000237216; ENSG00000276051" "HLA-G" "hsa:3135; P17693" "Proteasome degradation; Allograft rejection; Ebola virus infection in host; TAR syndrome" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ER-Phagosome pathway; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon gamma signaling; Interferon alpha/beta signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway" "11" "0" "1.064" "1.066" "1.124" "1.004" "1.023" "1.039" "1.086" "1.090" "1.027" "203.3" "216.2" "216.7" "228.6" "204.1" "208.0" "211.2" "220.8" "221.5" "208.8" "" "" "" "" "" "" "" "" "" "" "190.5" "178.9" "201.2" "176.7" "174.0" "198.7" "193.0" "196.0" "221.5" "201.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6666030451106529783" "False" "High" "IsMasterProtein" "Q9NRY2" "SOSS complex subunit C OS=Homo sapiens OX=9606 GN=INIP PE=1 SV=1" "0.000" "False" "7.540" "21" "2" "4" "2" "104" "11.4" "9.25" "12.70" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf15925" "58493" "ENSG00000148153" "INIP" "hsa:58493; Q5VWJ7; Q96E04; Q9NRY2; Q9P090" "" "" "0" "0" "1.095" "0.939" "1.038" "1.023" "0.891" "0.973" "0.932" "0.987" "0.916" "199.9" "218.8" "187.8" "207.6" "204.4" "178.2" "194.6" "186.3" "197.2" "183.2" "" "" "" "" "" "" "" "" "" "" "187.3" "181.1" "174.3" "160.5" "174.3" "170.2" "177.8" "165.4" "197.2" "176.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8586542513876721198" "False" "High" "IsMasterProtein" "O43502" "DNA repair protein RAD51 homolog 3 OS=Homo sapiens OX=9606 GN=RAD51C PE=1 SV=1" "0.000" "False" "7.539" "6" "2" "3" "2" "376" "42.2" "6.74" "10.79" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "5889" "ENSG00000108384" "RAD51C" "hsa:5889; O43502; O43503; Q3B783" "DNA repair pathways, full network" "Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination" "12" "0" "1.250" "1.070" "1.208" "1.212" "1.075" "1.087" "1.117" "1.108" "1.008" "170.9" "213.8" "182.8" "206.5" "207.1" "183.8" "185.8" "190.9" "189.4" "172.3" "" "" "" "" "" "" "" "" "" "" "160.2" "176.9" "169.7" "159.6" "176.5" "175.7" "169.8" "169.5" "189.4" "165.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3575198767162097907" "False" "High" "IsMasterProtein" "Q9BXV9" "EKC/KEOPS complex subunit GON7 OS=Homo sapiens OX=9606 GN=GON7 PE=1 SV=2" "0.000" "False" "7.528" "27" "2" "2" "2" "100" "10.9" "4.27" "10.06" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf15387" "84520" "ENSG00000170270; ENSG00000275619" "GON7" "Q0D2N1; Q0P6C4; Q3B7W5; Q9BXV9" "" "" "0" "0" "0.967" "0.918" "0.871" "0.901" "0.867" "0.778" "0.807" "0.715" "0.845" "983.4" "951.4" "902.9" "856.1" "885.9" "852.9" "765.1" "794.0" "702.9" "831.1" "" "" "" "" "" "" "" "" "" "" "921.5" "787.3" "838.2" "661.8" "755.1" "814.9" "699.1" "705.0" "702.9" "800.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3973232294886296363" "False" "High" "IsMasterProtein" "Q9HCJ3" "Ribonucleoprotein PTB-binding 2 OS=Homo sapiens OX=9606 GN=RAVER2 PE=1 SV=2" "0.000" "False" "7.521" "3" "2" "3" "2" "691" "74.3" "7.47" "10.83" "2" "" "nucleus;other cell component" "" "Pf00076" "55225" "ENSG00000162437" "RAVER2" "hsa:55225; Q6P141; Q9HCJ3; Q9NPV7" "" "" "0" "0" "1.008" "1.040" "0.945" "1.055" "0.987" "0.916" "0.905" "0.934" "1.014" "329.9" "332.7" "343.0" "311.8" "348.2" "325.6" "302.3" "298.5" "308.0" "334.7" "" "" "" "" "" "" "" "" "" "" "309.1" "275.3" "318.5" "241.1" "296.8" "311.1" "276.2" "265.0" "308.0" "322.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7205134673462845767" "False" "High" "IsMasterProtein" "Q86Y91" "Kinesin-like protein KIF18B OS=Homo sapiens OX=9606 GN=KIF18B PE=1 SV=4" "0.000" "False" "7.520" "3" "3" "4" "3" "852" "93.0" "8.62" "11.66" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "146909" "ENSG00000186185" "KIF18B" "A0A0C4DGP2; A0A0C4DGP5; A6NJI2; B7ZM49; B9EGM8; D5L6I1; hsa:146909; Q86Y91" "" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "2" "0" "0.976" "0.995" "1.123" "0.990" "1.084" "0.942" "0.850" "1.071" "1.024" "71.6" "69.9" "71.3" "80.5" "70.9" "77.7" "67.5" "60.9" "76.8" "73.4" "" "" "" "" "" "" "" "" "" "" "67.1" "57.9" "66.2" "62.2" "60.5" "74.2" "61.7" "54.1" "76.8" "70.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6611035198024909537" "False" "High" "IsMasterProtein" "O43167" "Zinc finger and BTB domain-containing protein 24 OS=Homo sapiens OX=9606 GN=ZBTB24 PE=1 SV=2" "0.000" "False" "7.495" "4" "3" "4" "3" "697" "78.2" "7.61" "12.06" "3" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "9841" "ENSG00000112365" "ZBTB24" "hsa:9841; O43167; Q17RC6; Q5TED5; Q8N455" "" "" "0" "0" "1.053" "1.034" "0.996" "0.948" "0.935" "0.948" "0.720" "0.813" "0.998" "118.8" "125.0" "122.8" "118.3" "112.6" "111.0" "112.6" "85.5" "96.6" "118.5" "" "" "" "" "" "" "" "" "" "" "111.3" "103.5" "114.0" "91.4" "96.0" "106.1" "102.9" "75.9" "96.6" "114.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6380773280211833227" "False" "High" "IsMasterProtein" "Q9Y508" "E3 ubiquitin-protein ligase RNF114 OS=Homo sapiens OX=9606 GN=RNF114 PE=1 SV=1" "0.000" "False" "7.489" "11" "3" "4" "3" "228" "25.7" "7.25" "10.60" "3" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf05605, Pf13445, Pf18574" "55905" "ENSG00000124226" "RNF114" "B2RDQ9; B4DWY5; E1P627; hsa:55905; Q6N0B0; Q9Y508" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.058" "0.933" "0.962" "1.054" "0.967" "1.070" "0.981" "0.897" "0.961" "573.3" "606.3" "534.7" "551.8" "604.3" "554.4" "613.4" "562.2" "514.3" "551.2" "" "" "" "" "" "" "" "" "" "" "537.2" "501.7" "496.4" "426.5" "515.1" "529.7" "560.5" "499.2" "514.3" "530.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3192969394575095847" "False" "High" "IsMasterProtein" "Q9BT17" "Mitochondrial ribosome-associated GTPase 1 OS=Homo sapiens OX=9606 GN=MTG1 PE=1 SV=2" "0.000" "False" "7.487" "8" "3" "3" "3" "334" "37.2" "9.47" "9.31" "3" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf01926" "92170" "ENSG00000148824" "MTG1" "hsa:92170; Q5VWX8; Q6PIY9; Q8IYJ4; Q8NC48; Q9BT17; Q9BVU8" "" "" "0" "0" "1.002" "1.037" "1.100" "1.027" "1.056" "0.993" "0.986" "0.971" "1.054" "532.0" "533.2" "551.9" "585.0" "546.4" "561.6" "528.1" "524.7" "516.8" "560.6" "" "" "" "" "" "" "" "" "" "" "498.5" "441.2" "512.4" "452.2" "465.7" "536.5" "482.6" "465.8" "516.8" "539.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1329977133710577893" "False" "High" "IsMasterProtein" "Q96EZ8" "Microspherule protein 1 OS=Homo sapiens OX=9606 GN=MCRS1 PE=1 SV=1" "0.000" "False" "7.478" "6" "3" "3" "3" "462" "51.8" "9.38" "8.83" "3" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf00498, Pf13325" "10445" "ENSG00000187778" "MCRS1" "hsa:10445; O14742; O75497; Q6VN53; Q7Z372; Q96EZ8" "3q29 copy number variation syndrome; 8p23.1 copy number variation syndrome" "DNA Damage Recognition in GG-NER; UCH proteinases; Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "6" "0" "1.016" "0.989" "1.070" "1.019" "0.974" "0.980" "0.987" "0.965" "1.021" "454.6" "462.1" "449.5" "486.5" "463.1" "442.8" "445.6" "448.6" "438.5" "463.9" "" "" "" "" "" "" "" "" "" "" "426.0" "382.4" "417.3" "376.1" "394.7" "423.1" "407.1" "398.3" "438.5" "446.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4422070484711978078" "False" "High" "IsMasterProtein" "O95684" "Centrosomal protein 43 OS=Homo sapiens OX=9606 GN=CEP43 PE=1 SV=1" "0.000" "False" "7.474" "7" "2" "2" "2" "399" "43.0" "4.81" "8.31" "2" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf09398" "11116" "ENSG00000213066" "CEP43" "A8K1D1; B2R705; hsa:11116; O95684; Q49AI0; Q5R3F6; Q96EW1" "Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "11" "0" "0.979" "0.930" "0.925" "1.015" "1.071" "0.954" "1.032" "1.050" "0.998" "354.2" "346.9" "329.3" "327.7" "359.7" "379.5" "337.9" "365.6" "371.9" "353.5" "" "" "" "" "" "" "" "" "" "" "331.9" "287.1" "305.7" "253.3" "306.6" "362.6" "308.8" "324.7" "371.9" "340.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4904792924861238037" "False" "High" "IsMasterProtein" "Q9Y5J6" "Mitochondrial import inner membrane translocase subunit Tim10 B OS=Homo sapiens OX=9606 GN=TIMM10B PE=1 SV=1" "0.000" "False" "7.472" "33" "2" "2" "2" "103" "11.6" "7.43" "6.62" "2" "cell adhesion;cell organization and biogenesis;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02953" "26515" "ENSG00000132286" "TIMM10B" "hsa:26515; Q96FF3; Q9Y5J6" "" "Mitochondrial protein import" "1" "0" "1.179" "0.807" "1.278" "1.099" "0.817" "1.225" "0.887" "0.854" "0.949" "181.9" "214.5" "146.9" "232.6" "199.9" "148.7" "222.8" "161.4" "155.4" "172.6" "" "" "" "" "" "" "" "" "" "" "170.5" "177.5" "136.4" "179.8" "170.4" "142.1" "203.6" "143.3" "155.4" "166.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4154792399073788951" "False" "High" "IsMasterProtein" "Q13541" "Eukaryotic translation initiation factor 4E-binding protein 1 OS=Homo sapiens OX=9606 GN=EIF4EBP1 PE=1 SV=3" "0.000" "False" "7.465" "32" "2" "3" "2" "118" "12.6" "5.48" "11.30" "2" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05456" "1978" "ENSG00000187840" "EIF4EBP1" "B2R502; D3DSW8; hsa:1978; Q13541; Q6IBN3" "Translation factors; AMP-activated protein kinase signaling; Target of rapamycin signaling; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; RAC1/PAK1/p38/MMP2 pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Hypertrophy model; Acute myeloid leukemia; Interferon type I signaling pathways; ErbB signaling pathway" "mTORC1-mediated signalling; Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S" "32" "0" "1.060" "1.143" "1.051" "1.133" "1.196" "1.072" "1.066" "0.933" "1.134" "204.4" "216.6" "233.7" "214.8" "231.5" "244.4" "219.1" "217.9" "190.8" "231.8" "" "" "" "" "" "" "" "" "" "" "191.5" "179.3" "217.0" "166.0" "197.3" "233.5" "200.2" "193.4" "190.8" "223.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2774592991242960215" "False" "High" "IsMasterProtein" "Q9H0H0" "Integrator complex subunit 2 OS=Homo sapiens OX=9606 GN=INTS2 PE=1 SV=2" "0.000" "False" "7.464" "3" "3" "4" "3" "1204" "134.2" "6.05" "10.66" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "" "Pf14750" "57508" "ENSG00000108506" "INTS2" "hsa:57508; Q9H0H0; Q9ULD3" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "1.257" "1.373" "1.573" "1.218" "1.302" "1.478" "1.146" "1.311" "1.195" "34.8" "43.8" "47.8" "54.8" "42.4" "45.3" "51.5" "39.9" "45.6" "41.6" "" "" "" "" "" "" "" "" "" "" "32.6" "36.2" "44.4" "42.3" "36.1" "43.3" "47.0" "35.4" "45.6" "40.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8790786939717611867" "False" "High" "IsMasterProtein" "Q15723" "ETS-related transcription factor Elf-2 OS=Homo sapiens OX=9606 GN=ELF2 PE=1 SV=2" "0.000" "False" "7.464" "3" "2" "3" "2" "593" "63.9" "6.57" "11.17" "2" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf12310" "1998" "ENSG00000109381" "ELF2" "E9PCX3; hsa:1998; Q15723; Q15724; Q15725; Q6P1K5" "" "RUNX1 regulates transcription of genes involved in BCR signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4854644692515831998" "False" "High" "IsMasterProtein" "Q86X76" "Deaminated glutathione amidase OS=Homo sapiens OX=9606 GN=NIT1 PE=1 SV=2" "0.000" "False" "7.463" "8" "3" "3" "3" "327" "35.9" "7.74" "9.19" "3" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00795" "4817" "ENSG00000158793" "NIT1" "B1AQP3; D3DVF4; hsa:4817; O76091; Q86X76" "" "" "0" "0" "1.075" "1.028" "1.039" "1.025" "1.102" "0.931" "1.005" "1.063" "1.066" "186.7" "200.7" "191.9" "194.0" "191.3" "205.7" "173.7" "187.6" "198.4" "199.0" "" "" "" "" "" "" "" "" "" "" "174.9" "166.1" "178.2" "149.9" "163.0" "196.5" "158.7" "166.6" "198.4" "191.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "370234138651289741" "False" "High" "IsMasterProtein" "Q96RS0" "Trimethylguanosine synthase OS=Homo sapiens OX=9606 GN=TGS1 PE=1 SV=3" "0.000" "False" "7.449" "3" "3" "4" "3" "853" "96.6" "4.94" "7.75" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09445" "96764" "ENSG00000137574" "TGS1" "A6NJQ5; hsa:96764; Q5GH23; Q8TDG9; Q96QU3; Q96RS0; Q9H5V3" "" "Heme signaling; Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); RORA activates gene expression; snRNP Assembly" "11" "0" "0.942" "1.078" "1.115" "1.131" "1.068" "1.169" "1.014" "1.087" "0.978" "103.5" "97.5" "111.6" "115.5" "117.1" "110.5" "121.1" "105.0" "112.6" "101.3" "" "" "" "" "" "" "" "" "" "" "97.0" "80.7" "103.6" "89.3" "99.8" "105.6" "110.6" "93.2" "112.6" "97.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-998134309870178967" "False" "High" "IsMasterProtein" "P47974" "mRNA decay activator protein ZFP36L2 OS=Homo sapiens OX=9606 GN=ZFP36L2 PE=1 SV=3" "0.000" "False" "7.449" "5" "2" "4" "2" "494" "51.0" "8.16" "16.03" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf04553" "678" "ENSG00000152518" "ZFP36L2" "hsa:678; P47974; Q53TB4; Q9BSJ3" "Pre-implantation embryo; TYROBP causal network in microglia" "M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "1.026" "0.909" "0.946" "0.934" "0.969" "0.810" "0.742" "0.816" "0.902" "366.7" "376.2" "333.4" "347.1" "342.6" "355.4" "297.1" "272.3" "299.1" "330.7" "" "" "" "" "" "" "" "" "" "" "343.6" "311.3" "309.6" "268.3" "292.0" "339.5" "271.4" "241.7" "299.1" "318.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7100137965290358990" "False" "High" "IsMasterProtein" "Q9UJW0" "Dynactin subunit 4 OS=Homo sapiens OX=9606 GN=DCTN4 PE=1 SV=1" "0.000" "False" "7.449" "7" "2" "2" "2" "460" "52.3" "7.34" "7.35" "2" "" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf05502" "51164" "ENSG00000132912" "DCTN4" "B3KWW0; D3DQH0; E5RGT5; hsa:51164; Q8TAN8; Q9UJW0" "Vasopressin-regulated water reabsorption" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; MHC class II antigen presentation; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic" "5" "0" "0.939" "0.941" "0.936" "0.966" "1.035" "0.962" "0.988" "1.075" "0.947" "271.7" "255.0" "255.7" "254.3" "262.5" "281.2" "261.5" "268.6" "292.0" "257.3" "" "" "" "" "" "" "" "" "" "" "254.6" "211.0" "237.4" "196.6" "223.8" "268.6" "238.9" "238.4" "292.0" "247.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1247972566185408077" "False" "High" "IsMasterProtein" "Q9UNT1" "Rab-like protein 2B OS=Homo sapiens OX=9606 GN=RABL2B PE=1 SV=1" "0.000" "False" "7.448" "10" "3" "3" "3" "228" "26.1" "4.89" "8.53" "3" "cell organization and biogenesis;transport" "cytoskeleton;other cell component" "other molecular function" "Pf00071" "11158" "ENSG00000079974" "RABL2B" "hsa:11158; Q5TZT8; Q96C33; Q9UNT1" "3q29 copy number variation syndrome" "" "1" "0" "0.926" "1.014" "0.867" "0.938" "0.958" "0.899" "0.900" "0.965" "0.936" "816.7" "755.9" "828.2" "708.3" "765.9" "782.1" "734.1" "734.9" "787.8" "764.7" "" "" "" "" "" "" "" "" "" "" "765.2" "625.5" "768.9" "547.6" "652.8" "747.2" "670.7" "652.5" "787.8" "736.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1157936408086935804" "False" "High" "IsMasterProtein" "O75446" "Histone deacetylase complex subunit SAP30 OS=Homo sapiens OX=9606 GN=SAP30 PE=1 SV=1" "0.000" "False" "7.435" "10" "3" "6" "3" "220" "23.3" "9.17" "17.31" "3" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13866, Pf13867" "8819" "ENSG00000164105" "SAP30" "D3DP38; hsa:8819; O75446" "Retinoblastoma gene in cancer; Notch signaling pathway" "Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression" "5" "0" "0.973" "1.023" "1.089" "1.053" "1.033" "1.038" "0.994" "0.994" "1.048" "472.5" "459.6" "483.2" "514.7" "497.4" "488.3" "490.6" "469.5" "469.7" "495.0" "" "" "" "" "" "" "" "" "" "" "442.7" "380.3" "448.6" "397.9" "423.9" "466.5" "448.3" "416.9" "469.7" "476.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-985839782283071822" "False" "High" "IsMasterProtein" "P10619" "Lysosomal protective protein OS=Homo sapiens OX=9606 GN=CTSA PE=1 SV=2" "0.000" "False" "7.425" "6" "3" "3" "3" "480" "54.4" "6.61" "9.27" "3" "protein metabolism;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00450" "5476" "ENSG00000064601" "CTSA" "B2R798; hsa:5476; P10619; Q561W6; Q5JZH1; Q96KJ2; Q9BR08; Q9BW68" "Ciliary landscape" "MHC class II antigen presentation; Neutrophil degranulation; Sialic acid metabolism; Glycosphingolipid catabolism; Defective NEU1 causes sialidosis" "6" "0" "0.854" "0.989" "0.706" "0.929" "0.973" "0.822" "0.897" "0.971" "0.888" "624.0" "532.9" "616.8" "440.3" "579.7" "606.9" "512.8" "559.9" "605.7" "554.2" "" "" "" "" "" "" "" "" "" "" "584.6" "441.0" "572.7" "340.4" "494.1" "579.9" "468.6" "497.2" "605.7" "533.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8653500297928283924" "False" "High" "IsMasterProtein" "Q9H7Z3" "Nuclear exosome regulator NRDE2 OS=Homo sapiens OX=9606 GN=NRDE2 PE=1 SV=3" "0.000" "False" "7.421" "3" "3" "3" "3" "1164" "132.6" "7.68" "8.23" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "" "Pf08424" "55051" "ENSG00000119720" "NRDE2" "B4DH71; hsa:55051; Q4G0A7; Q9H7Z3; Q9NWH6" "" "" "0" "0" "0.998" "1.112" "1.195" "1.125" "1.027" "1.062" "1.016" "1.049" "1.039" "161.0" "160.7" "179.0" "192.5" "181.2" "165.4" "171.0" "163.6" "168.9" "167.3" "" "" "" "" "" "" "" "" "" "" "150.9" "133.0" "166.2" "148.8" "154.4" "158.0" "156.2" "145.3" "168.9" "161.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8490030146092636123" "False" "High" "IsMasterProtein" "Q7Z422" "SUZ RNA-binding domain-containing OS=Homo sapiens OX=9606 GN=SZRD1 PE=1 SV=1" "0.000" "False" "7.420" "23" "3" "3" "3" "152" "17.0" "8.95" "9.17" "3" "" "" "" "Pf12752, Pf12901" "26099" "ENSG00000055070; ENSG00000291379" "SZRD1" "A8MXJ2; C9K0U0; hsa:26099; Q7Z422; Q7Z424; Q8IVM2; Q8TBV3; Q9Y403" "" "" "0" "0" "1.020" "1.017" "0.979" "0.998" "0.936" "0.984" "1.026" "0.941" "1.023" "156.4" "159.5" "159.0" "153.2" "156.1" "146.4" "153.8" "160.4" "147.1" "160.0" "" "" "" "" "" "" "" "" "" "" "146.5" "132.0" "147.6" "118.4" "133.1" "139.9" "140.6" "142.5" "147.1" "154.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6342427626710048975" "False" "High" "IsMasterProtein" "Q96SW2" "Protein cereblon OS=Homo sapiens OX=9606 GN=CRBN PE=1 SV=1" "0.000" "False" "7.413" "7" "3" "4" "3" "442" "50.5" "5.63" "10.69" "3" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf02190, Pf03226" "51185" "ENSG00000113851" "CRBN" "B2R6H4; C9IZA9; C9JAH6; hsa:51185; Q6AI62; Q6NVZ0; Q96SW2; Q9UHW4" "" "Potential therapeutics for SARS" "1" "0" "0.908" "0.981" "1.029" "0.967" "0.966" "0.933" "0.995" "1.017" "0.970" "306.2" "278.1" "300.6" "315.1" "296.1" "295.9" "285.6" "304.7" "311.5" "297.0" "" "" "" "" "" "" "" "" "" "" "286.9" "230.1" "279.0" "243.6" "252.4" "282.7" "261.0" "270.5" "311.5" "286.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-768881656379736442" "False" "High" "IsMasterProtein" "Q9BT73" "Proteasome assembly chaperone 3 OS=Homo sapiens OX=9606 GN=PSMG3 PE=1 SV=1" "0.000" "False" "7.402" "23" "2" "3" "2" "122" "13.1" "7.88" "10.28" "2" "cell organization and biogenesis" "other cell component" "other molecular function" "Pf10178" "84262" "ENSG00000157778" "PSMG3" "A4D216; A8MPW2; hsa:84262; Q9BT73" "" "" "0" "0" "1.124" "1.161" "1.484" "1.170" "1.276" "1.349" "1.093" "1.242" "1.257" "95.3" "107.1" "110.6" "141.4" "111.5" "121.5" "128.5" "104.1" "118.3" "119.8" "" "" "" "" "" "" "" "" "" "" "89.3" "88.6" "102.7" "109.3" "95.0" "116.1" "117.4" "92.4" "118.3" "115.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7766499346682965111" "False" "High" "IsMasterProtein" "Q99583" "Max-binding protein MNT OS=Homo sapiens OX=9606 GN=MNT PE=1 SV=1" "0.000" "False" "7.401" "5" "3" "4" "3" "582" "62.3" "8.78" "11.20" "3" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "4335" "ENSG00000070444" "MNT" "A8K6D1; D3DTI7; hsa:4335; Q1ED38; Q99583" "" "" "0" "0" "1.029" "1.022" "1.041" "1.083" "1.002" "1.051" "1.027" "0.992" "1.052" "340.4" "350.2" "347.9" "354.4" "368.5" "341.0" "357.7" "349.6" "337.7" "358.0" "" "" "" "" "" "" "" "" "" "" "319.0" "289.8" "323.0" "274.0" "314.1" "325.8" "326.9" "310.5" "337.7" "344.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4298882931648225908" "False" "High" "IsMasterProtein" "Q9UGJ1" "Gamma-tubulin complex component 4 OS=Homo sapiens OX=9606 GN=TUBGCP4 PE=1 SV=1" "0.000" "False" "7.387" "5" "3" "3" "3" "667" "76.0" "6.65" "6.55" "3" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;other cytoplasmic organelle" "cytoskeletal activity" "Pf04130, Pf17681" "27229" "ENSG00000137822" "TUBGCP4" "B3KNK6; hsa:27229; Q969X3; Q9NVF0; Q9UGJ1" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "4" "0" "0.778" "1.037" "0.931" "0.876" "0.947" "1.194" "0.943" "0.958" "0.934" "329.3" "256.1" "341.5" "306.7" "288.4" "311.8" "393.4" "310.6" "315.4" "307.5" "" "" "" "" "" "" "" "" "" "" "308.6" "211.9" "317.1" "237.1" "245.9" "297.9" "359.5" "275.8" "315.4" "296.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2912767912009988876" "False" "High" "IsMasterProtein" "Q8TCE6" "DENN domain-containing protein 10 OS=Homo sapiens OX=9606 GN=DENND10 PE=1 SV=1" "0.000" "False" "7.385" "7" "2" "2" "2" "357" "40.5" "6.61" "6.45" "2" "transport;other biological processes" "other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf08616" "404636" "ENSG00000119979" "DENND10" "B1AMV6; B4DDC3; D3DRC8; hsa:404636; Q8TCE6; Q9NXW4" "" "" "0" "0" "1.008" "0.958" "1.046" "1.006" "1.022" "1.015" "0.960" "0.989" "1.012" "470.8" "474.5" "451.2" "492.3" "473.4" "481.0" "477.9" "452.0" "465.5" "476.3" "" "" "" "" "" "" "" "" "" "" "441.1" "392.7" "418.8" "380.6" "403.5" "459.6" "436.7" "401.3" "465.5" "458.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7404612744659791932" "False" "High" "IsMasterProtein" "Q01658" "Protein Dr1 OS=Homo sapiens OX=9606 GN=DR1 PE=1 SV=1" "0.000" "False" "7.382" "16" "3" "3" "3" "176" "19.4" "4.75" "10.61" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "1810" "ENSG00000117505" "DR1" "hsa:1810; Q01658" "" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "2" "0" "1.046" "0.952" "0.936" "1.002" "0.935" "0.968" "0.949" "0.905" "0.930" "1019.5" "1066.1" "970.3" "954.3" "1021.5" "953.2" "987.1" "967.6" "923.0" "948.1" "" "" "" "" "" "" "" "" "" "" "955.2" "882.2" "900.8" "737.7" "870.7" "910.7" "901.9" "859.1" "923.0" "912.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3469585503029869905" "False" "High" "IsMasterProtein" "Q96PU5" "E3 ubiquitin-protein ligase NEDD4-like OS=Homo sapiens OX=9606 GN=NEDD4L PE=1 SV=2" "0.000" "False" "7.372" "3" "3" "4" "1" "975" "111.9" "5.82" "10.55" "3" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf00397, Pf00632" "23327" "ENSG00000049759" "NEDD4L" "hsa:23327; O43165; Q3LSM7; Q7Z5F1; Q7Z5F2; Q7Z5N3; Q8N5A7; Q8WUU9; Q96PU5; Q9BW58; Q9H2W4; Q9NT88" "TGF-beta signaling pathway" "Antigen processing: Ubiquitination & Proteasome degradation; Budding and maturation of HIV virion; Stimuli-sensing channels; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "6" "0" "1.325" "1.168" "1.534" "1.283" "1.225" "1.107" "1.318" "1.245" "1.216" "28.7" "38.0" "33.5" "44.0" "36.8" "35.1" "31.7" "37.8" "35.7" "34.9" "" "" "" "" "" "" "" "" "" "" "26.9" "31.5" "31.1" "34.0" "31.4" "33.6" "29.0" "33.6" "35.7" "33.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6044339121918528105" "False" "High" "IsMasterProtein" "O75676" "Ribosomal protein S6 kinase alpha-4 OS=Homo sapiens OX=9606 GN=RPS6KA4 PE=1 SV=1" "0.000" "False" "7.371" "3" "3" "3" "2" "772" "85.6" "8.28" "9.56" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433" "8986" "ENSG00000162302" "RPS6KA4" "A8K7Z8; hsa:8986; O75585; O75676; Q53ES8" "MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways" "Recycling pathway of L1" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "43561169089107894" "False" "High" "IsMasterProtein" "Q5VWG9" "Transcription initiation factor TFIID subunit 3 OS=Homo sapiens OX=9606 GN=TAF3 PE=1 SV=1" "0.000" "False" "7.363" "2" "2" "3" "2" "929" "103.5" "9.06" "9.34" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus" "other molecular function" "Pf00628, Pf07524" "83860" "ENSG00000165632" "TAF3" "hsa:83860; Q05DA0; Q5VWG9; Q6GMS5; Q6P6B5; Q86VY6; Q9BQS9; Q9UFI8" "" "Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "9" "0" "0.970" "0.972" "0.877" "0.985" "0.958" "0.981" "0.956" "0.956" "0.972" "300.7" "291.7" "292.2" "263.8" "296.2" "288.1" "295.0" "287.5" "287.3" "292.3" "" "" "" "" "" "" "" "" "" "" "281.7" "241.4" "271.3" "203.9" "252.5" "275.3" "269.6" "255.3" "287.3" "281.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4022881073250375863" "False" "High" "IsMasterProtein" "P16455" "Methylated-DNA--protein-cysteine methyltransferase OS=Homo sapiens OX=9606 GN=MGMT PE=1 SV=1" "0.000" "False" "7.363" "11" "2" "3" "2" "207" "21.6" "8.10" "11.69" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01035, Pf02870" "4255" "ENSG00000170430" "MGMT" "P16455; Q5VY78" "Direct reversal repair; DNA repair pathways, full network; p53 transcriptional gene network" "MGMT-mediated DNA damage reversal" "4" "0" "1.038" "0.981" "0.926" "0.983" "1.076" "0.998" "1.038" "1.006" "1.026" "226.6" "235.1" "222.3" "209.8" "222.8" "243.9" "226.1" "235.3" "228.0" "232.5" "" "" "" "" "" "" "" "" "" "" "212.3" "194.6" "206.4" "162.2" "189.9" "233.0" "206.6" "208.9" "228.0" "223.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8206347650273111002" "False" "High" "IsMasterProtein" "Q9H7C9" "Mth938 domain-containing protein OS=Homo sapiens OX=9606 GN=AAMDC PE=1 SV=1" "0.000" "False" "7.324" "17" "2" "2" "2" "122" "13.3" "8.46" "7.55" "2" "other biological processes" "other cell component" "" "Pf04430" "28971" "ENSG00000087884" "AAMDC" "hsa:28971; Q96AQ4; Q9H7C9; Q9Y6B1" "" "" "0" "0" "0.928" "0.998" "0.914" "0.973" "0.994" "0.906" "0.935" "0.936" "0.939" "506.4" "469.9" "505.4" "463.0" "492.7" "503.6" "458.6" "473.5" "474.2" "475.5" "" "" "" "" "" "" "" "" "" "" "474.5" "388.9" "469.2" "357.9" "420.0" "481.2" "419.0" "420.4" "474.2" "457.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7927368921331951811" "False" "High" "IsMasterProtein" "Cont_O46375" "Transthyretin OS=Bos taurus OX=9913 GN=TTR PE=1 SV=1" "0.000" "True" "7.318" "17" "2" "2" "2" "147" "15.7" "6.30" "6.27" "2" "other metabolic processes;signal transduction" "non-structural extracellular" "signal transduction activity or receptor binding;other molecular function" "Pf00576" "102267525; 104980319; 109577967; 280948" "ENSBGRG00000022634; ENSBIXG00000008920; ENSBIXG00005017301; ENSBTAG00000010991" "TTR" "A0A4W2BU20; A0A6B0QTW8; A0A6P3GKP7; A0A6P5DX06; A0A8B9YDR1; bbis:104980319; biu:109577967; bom:102267525; bta:280948; O46375; Q3SZ91" "" "Neutrophil degranulation; Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision)" "3" "0" "1.070" "1.047" "1.027" "1.250" "1.218" "1.045" "1.197" "1.189" "1.084" "294.1" "314.5" "307.9" "301.9" "367.5" "358.3" "307.4" "352.1" "349.7" "318.7" "" "" "" "" "" "" "" "" "" "" "275.5" "260.3" "285.8" "233.4" "313.2" "342.3" "280.9" "312.6" "349.7" "306.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1936196132069053391" "False" "High" "IsMasterProtein" "Q8WXA9" "Splicing regulatory glutamine/lysine-rich protein 1 OS=Homo sapiens OX=9606 GN=SREK1 PE=1 SV=1" "0.000" "False" "7.317" "5" "2" "4" "2" "508" "59.3" "10.39" "10.66" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00076" "140890" "ENSG00000153914" "SREK1" "A4FTW3; hsa:140890; Q2M1J0; Q86X37; Q8WXA9" "mRNA processing" "" "1" "0" "1.160" "1.126" "1.149" "1.037" "1.019" "1.130" "0.951" "1.126" "1.070" "344.5" "399.8" "387.9" "395.9" "357.2" "351.0" "389.4" "327.5" "388.1" "368.8" "" "" "" "" "" "" "" "" "" "" "322.8" "330.8" "360.1" "306.0" "304.5" "335.3" "355.8" "290.8" "388.1" "355.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2936218477733222076" "False" "High" "IsMasterProtein" "Q8N6T7" "NAD-dependent protein deacylase sirtuin-6 OS=Homo sapiens OX=9606 GN=SIRT6 PE=1 SV=2" "0.000" "False" "7.315" "10" "3" "3" "3" "355" "39.1" "9.19" "4.57" "3" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02146" "51548" "ENSG00000077463" "SIRT6" "B2RCD0; hsa:51548; O75291; Q6IAF5; Q6PK99; Q8N6T7; Q8NCD2; Q9BSI5; Q9BWP3; Q9NRC7; Q9UQD1" "SREBF and miR33 in cholesterol and lipid homeostasis; NAD+ metabolism; NAD+ biosynthetic pathways; Thermogenesis; Thyroid hormones production and peripheral downstream signaling effects; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; 10q11.21q11.23 copy number variation syndrome" "Pre-NOTCH Transcription and Translation; Processing of DNA double-strand break ends" "9" "0" "0.905" "0.874" "1.078" "1.061" "0.991" "1.034" "0.982" "0.970" "0.883" "81.1" "73.4" "70.8" "87.4" "86.0" "80.3" "83.8" "79.6" "78.6" "71.6" "" "" "" "" "" "" "" "" "" "" "76.0" "60.7" "65.7" "67.6" "73.3" "76.7" "76.6" "70.7" "78.6" "69.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2383613337026514959" "False" "High" "IsMasterProtein" "Q93052" "Lipoma-preferred partner OS=Homo sapiens OX=9606 GN=LPP PE=1 SV=1" "0.000" "False" "7.314" "3" "2" "2" "2" "612" "65.7" "7.37" "7.09" "2" "cell adhesion" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "4026" "ENSG00000145012" "LPP" "A1L4L6; D3DNV6; hsa:4026; Q8NFX5; Q93052" "MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement" "" "1" "0" "1.116" "1.007" "1.119" "1.135" "1.110" "1.071" "1.077" "1.016" "1.113" "285.3" "318.4" "287.3" "319.2" "323.7" "316.7" "305.6" "307.3" "289.9" "317.6" "" "" "" "" "" "" "" "" "" "" "267.3" "263.5" "266.8" "246.8" "276.0" "302.6" "279.2" "272.9" "289.9" "305.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-275352047723705183" "False" "High" "IsMasterProtein" "Q8TF09" "Dynein light chain roadblock-type 2 OS=Homo sapiens OX=9606 GN=DYNLRB2 PE=1 SV=1" "0.000" "False" "7.303" "13" "1" "2" "1" "96" "10.8" "7.50" "6.39" "1" "other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf03259" "83657" "ENSG00000168589" "DYNLRB2" "hsa:83657; Q8TF09" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome" "Intraflagellar transport" "4" "0" "0.947" "0.904" "1.064" "1.072" "0.902" "0.992" "0.946" "0.950" "0.960" "132.5" "125.6" "119.9" "141.0" "142.1" "119.5" "131.4" "125.4" "125.9" "127.2" "" "" "" "" "" "" "" "" "" "" "124.2" "103.9" "111.3" "109.0" "121.2" "114.2" "120.1" "111.3" "125.9" "122.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3037731205086659877" "False" "High" "IsMasterProtein" "P09234" "U1 small nuclear ribonucleoprotein C OS=Homo sapiens OX=9606 GN=SNRPC PE=1 SV=1" "0.000" "False" "7.299" "13" "2" "4" "2" "159" "17.4" "9.67" "14.60" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06220" "6631" "ENSG00000124562" "SNRPC" "hsa:6631; P09234; Q5TAL3" "" "mRNA Splicing - Major Pathway" "1" "0" "1.073" "1.108" "0.982" "0.917" "0.940" "1.068" "1.084" "1.029" "0.964" "272.2" "292.0" "301.5" "267.4" "249.6" "255.8" "290.6" "295.2" "280.0" "262.3" "" "" "" "" "" "" "" "" "" "" "255.0" "241.6" "279.9" "206.7" "212.7" "244.4" "265.6" "262.1" "280.0" "252.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8251896987743937176" "False" "High" "IsMasterProtein" "P53680" "AP-2 complex subunit sigma OS=Homo sapiens OX=9606 GN=AP2S1 PE=1 SV=2" "0.000" "False" "7.297" "18" "3" "4" "3" "142" "17.0" "6.18" "10.67" "3" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "1175" "ENSG00000042753" "AP2S1" "B2R4Z4; hsa:1175; O75977; P53680; Q6PK67" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome" "MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; Potential therapeutics for SARS; Recycling pathway of L1; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "18" "0" "1.027" "1.266" "1.140" "1.226" "1.168" "1.346" "1.124" "1.107" "1.084" "41.4" "42.5" "52.4" "47.2" "50.8" "48.4" "55.7" "46.5" "45.8" "44.9" "" "" "" "" "" "" "" "" "" "" "38.8" "35.2" "48.7" "36.5" "43.3" "46.2" "50.9" "41.3" "45.8" "43.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7022499983038261226" "False" "High" "IsMasterProtein" "Q1ED39" "Lysine-rich nucleolar protein 1 OS=Homo sapiens OX=9606 GN=KNOP1 PE=1 SV=1" "0.000" "False" "7.295" "6" "3" "3" "3" "458" "51.6" "9.86" "7.92" "3" "" "nucleus" "" "Pf15477" "400506" "ENSG00000103550" "KNOP1" "O43328; Q1ED39; Q5FWF3" "" "" "0" "0" "0.905" "0.905" "0.938" "1.079" "0.956" "1.039" "1.127" "1.041" "1.042" "175.7" "159.0" "159.1" "164.9" "189.7" "167.9" "182.6" "198.1" "183.0" "183.2" "" "" "" "" "" "" "" "" "" "" "164.7" "131.5" "147.7" "127.5" "161.7" "160.4" "166.9" "175.9" "183.0" "176.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-344337871911847900" "False" "High" "IsMasterProtein" "Q86X53" "Glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=ERICH1 PE=1 SV=1" "0.000" "False" "7.291" "5" "2" "2" "2" "443" "49.0" "4.78" "6.44" "2" "" "" "" "" "157697" "ENSG00000104714" "ERICH1" "A8K2J9; hsa:157697; Q86X53; Q9P063" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1411281452547832793" "False" "High" "IsMasterProtein" "Q9UPT9" "Ubiquitin carboxyl-terminal hydrolase 22 OS=Homo sapiens OX=9606 GN=USP22 PE=1 SV=2" "0.000" "False" "7.287" "6" "4" "6" "4" "525" "59.9" "8.05" "10.52" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00443, Pf02148" "23326" "ENSG00000124422" "USP22" "A0JNS3; hsa:23326; Q2NLE2; Q6MZY4; Q8TBS8; Q96IW5; Q9UPT9" "" "Ub-specific processing proteases; HATs acetylate histones" "2" "0" "0.947" "1.068" "1.032" "1.061" "1.036" "0.979" "1.026" "0.991" "1.051" "1142.4" "1081.8" "1220.6" "1178.5" "1212.2" "1183.6" "1118.3" "1172.5" "1131.7" "1200.8" "" "" "" "" "" "" "" "" "" "" "1070.5" "895.2" "1133.2" "911.0" "1033.3" "1130.8" "1021.8" "1041.1" "1131.7" "1156.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2902136520496705703" "False" "High" "IsMasterProtein" "Q8N3F8" "MICAL-like protein 1 OS=Homo sapiens OX=9606 GN=MICALL1 PE=1 SV=2" "0.000" "False" "7.278" "4" "4" "5" "4" "863" "93.4" "7.25" "11.70" "4" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00307, Pf00412, Pf12130" "85377" "ENSG00000100139" "MICALL1" "hsa:85377; Q5TI16; Q7RTP5; Q8N3F8; Q8N3N8; Q9BVL9; Q9BY92; Q9UH43; Q9UH44; Q9UH45" "" "" "0" "0" "0.880" "1.119" "1.048" "0.926" "1.065" "1.096" "0.910" "0.936" "0.959" "153.3" "134.9" "171.6" "160.6" "141.9" "163.2" "168.0" "139.6" "143.5" "147.0" "" "" "" "" "" "" "" "" "" "" "143.7" "111.6" "159.3" "124.2" "121.0" "156.0" "153.5" "123.9" "143.5" "141.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4869636170547335298" "False" "High" "IsMasterProtein" "Q9H257" "Caspase recruitment domain-containing protein 9 OS=Homo sapiens OX=9606 GN=CARD9 PE=1 SV=2" "0.000" "False" "7.269" "9" "3" "3" "3" "536" "62.2" "6.07" "6.81" "3" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00619" "64170" "ENSG00000187796" "CARD9" "hsa:64170; Q5SXM5; Q5SXM6; Q9H257; Q9H854" "Nucleotide-binding oligomerization domain (NOD) pathway" "CLEC7A (Dectin-1) signaling; NOD1/2 Signaling Pathway" "3" "0" "1.066" "0.939" "1.256" "1.079" "1.040" "1.031" "1.130" "1.121" "1.020" "38.2" "40.7" "35.8" "48.0" "41.2" "39.7" "39.3" "43.1" "42.8" "38.9" "" "" "" "" "" "" "" "" "" "" "35.8" "33.7" "33.3" "37.1" "35.1" "37.9" "35.9" "38.3" "42.8" "37.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7240944493038279722" "False" "High" "IsMasterProtein" "Q9Y676" "Small ribosomal subunit protein mS40 OS=Homo sapiens OX=9606 GN=MRPS18B PE=1 SV=1" "0.000" "False" "7.268" "8" "2" "2" "2" "258" "29.4" "9.38" "8.18" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01084" "28973" "ENSG00000203624; ENSG00000204568; ENSG00000223775; ENSG00000226111; ENSG00000227420; ENSG00000229861; ENSG00000233813" "MRPS18B" "A6NDQ0; hsa:28973; Q659G4; Q9BS27; Q9Y676" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.005" "1.067" "0.939" "1.009" "1.070" "0.984" "1.082" "0.876" "0.973" "570.3" "573.2" "608.7" "535.6" "575.3" "610.4" "561.1" "616.9" "499.7" "554.7" "" "" "" "" "" "" "" "" "" "" "534.3" "474.3" "565.1" "414.0" "490.4" "583.1" "512.7" "547.7" "499.7" "534.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7969170579020640520" "False" "High" "IsMasterProtein" "A6NKF1" "SAC3 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SAC3D1 PE=1 SV=2" "0.000" "False" "7.254" "5" "2" "3" "2" "404" "43.5" "8.69" "6.99" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf03399" "" "" "SAC3D1" "A6NKF1; A8MX08; Q99773" "" "" "0" "0" "1.124" "1.034" "1.073" "1.117" "1.097" "1.039" "1.045" "1.045" "1.085" "192.0" "215.8" "198.6" "206.0" "214.4" "210.6" "199.4" "200.6" "200.6" "208.2" "" "" "" "" "" "" "" "" "" "" "179.9" "178.6" "184.4" "159.2" "182.7" "201.2" "182.2" "178.1" "200.6" "200.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6438294564185077030" "False" "High" "IsMasterProtein" "Q9BPW8" "Protein NipSnap homolog 1 OS=Homo sapiens OX=9606 GN=NIPSNAP1 PE=1 SV=1" "0.000" "False" "7.249" "11" "3" "4" "2" "284" "33.3" "9.31" "9.61" "3" "other biological processes" "plasma membrane;other membranes;mitochondrion" "" "Pf07978" "8508" "ENSG00000184117" "NIPSNAP1" "B2RAY3; hsa:8508; O43800; Q9BPW8" "" "" "0" "0" "1.004" "1.071" "0.958" "1.066" "1.128" "0.944" "1.081" "1.005" "1.004" "422.9" "424.7" "453.0" "405.1" "450.7" "477.1" "399.3" "457.2" "425.1" "424.4" "" "" "" "" "" "" "" "" "" "" "396.2" "351.4" "420.5" "313.2" "384.1" "455.9" "364.9" "405.9" "425.1" "408.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2019204481334339745" "False" "High" "IsMasterProtein" "Q9H3R0" "Lysine-specific demethylase 4C OS=Homo sapiens OX=9606 GN=KDM4C PE=1 SV=2" "0.000" "False" "7.241" "2" "2" "2" "2" "1056" "119.9" "6.46" "7.17" "2" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02373, Pf02375, Pf13831, Pf13832, Pf18104" "23081" "ENSG00000107077" "KDM4C" "B4E1Y4; B7ZL46; F5H347; F5H7P0; hsa:23081; O94877; Q2M3M0; Q5JUC9; Q5VYJ2; Q5VYJ3; Q9H3R0" "" "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; HDMs demethylate histones" "2" "0" "0.983" "0.936" "1.051" "0.957" "0.998" "1.081" "0.990" "0.869" "0.962" "233.5" "229.6" "218.4" "245.4" "223.4" "233.0" "252.5" "231.2" "202.9" "224.6" "" "" "" "" "" "" "" "" "" "" "218.8" "190.0" "202.8" "189.7" "190.4" "222.6" "230.7" "205.3" "202.9" "216.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2851468461982241185" "False" "High" "IsMasterProtein" "P30626" "Sorcin OS=Homo sapiens OX=9606 GN=SRI PE=1 SV=1" "0.000" "False" "7.240" "15" "3" "7" "3" "198" "21.7" "5.59" "16.88" "3" "transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13499, Pf13833" "6717" "ENSG00000075142" "SRI" "A8MTH6; B4DKK2; D6W5Q0; hsa:6717; P30626" "" "Stimuli-sensing channels; Ion homeostasis; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels; Sodium/Calcium exchangers" "5" "0" "0.960" "0.951" "0.960" "1.038" "1.005" "1.031" "1.009" "0.961" "1.003" "647.6" "621.4" "615.6" "622.0" "672.4" "650.7" "667.7" "653.6" "622.6" "649.5" "" "" "" "" "" "" "" "" "" "" "606.8" "514.2" "571.5" "480.9" "573.1" "621.7" "610.1" "580.3" "622.6" "625.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3895404278384693276" "False" "High" "IsMasterProtein" "P08047" "Transcription factor Sp1 OS=Homo sapiens OX=9606 GN=SP1 PE=1 SV=3" "0.000" "False" "7.226" "5" "2" "3" "2" "785" "80.6" "7.34" "15.03" "2" "stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6667" "ENSG00000185591" "SP1" "E4Z9M7; G5E9M8; hsa:6667; P08047; Q86TN8; Q9H3Q5; Q9NR51; Q9NY21; Q9NYE7" "Androgen receptor signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; IL-17 signaling pathway; Androgen receptor network in prostate cancer; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Constitutive androstane receptor pathway; Estrogen receptor pathway; Nuclear receptors meta-pathway; Myometrial relaxation and contraction pathways; Copper homeostasis; Initiation of transcription and translation elongation at the HIV-1 LTR; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; Mitochondrial gene expression; Oxidative stress response; Breast cancer pathway; Ethanol metabolism production of ROS by CYP2E1; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Gastrin signaling pathway; IL-18 signaling pathway; Angiotensin II receptor type 1 pathway; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; Genetic causes of porto-sinusoidal vascular disease; HDAC6 interactions in the central nervous system; Pathways in cancer; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway" "PPARA activates gene expression; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Oncogene Induced Senescence; Activation of gene expression by SREBF (SREBP); SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Regulation of CDH11 gene transcription; NFE2L2 regulating tumorigenic genes" "42" "0" "1.059" "0.947" "0.949" "1.042" "1.053" "0.938" "1.070" "1.063" "0.985" "255.2" "270.2" "241.7" "242.2" "265.9" "268.7" "239.4" "273.1" "271.4" "251.3" "" "" "" "" "" "" "" "" "" "" "239.2" "223.6" "224.4" "187.2" "226.6" "256.7" "218.7" "242.5" "271.4" "242.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2389854899245022230" "False" "High" "IsMasterProtein" "A6NDU8" "RAB7A-interacting MON1-CCZ1 complex subunit 1 OS=Homo sapiens OX=9606 GN=RIMOC1 PE=1 SV=1" "0.000" "False" "7.225" "10" "3" "4" "3" "294" "33.6" "5.26" "14.32" "3" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus" "" "Pf17716" "285636" "ENSG00000205765" "RIMOC1" "A2RRM9; A6NDU8; hsa:285636" "" "" "0" "0" "1.058" "1.015" "1.033" "1.026" "0.998" "0.881" "0.860" "0.836" "0.970" "691.4" "731.3" "702.0" "714.2" "709.6" "690.4" "609.3" "594.5" "577.7" "670.7" "" "" "" "" "" "" "" "" "" "" "647.8" "605.1" "651.7" "552.1" "604.8" "659.6" "556.8" "527.9" "577.7" "645.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7992266646399474025" "False" "High" "IsMasterProtein" "Q9Y605" "MORF4 family-associated protein 1 OS=Homo sapiens OX=9606 GN=MRFAP1 PE=1 SV=1" "0.000" "False" "7.221" "25" "2" "3" "2" "127" "14.6" "4.70" "11.82" "2" "" "nucleus;other cell component" "" "Pf15155" "93621" "ENSG00000179010" "MRFAP1" "B3KVT2; D3DVT3; hsa:93621; Q9Y605" "" "" "0" "0" "0.949" "0.886" "0.937" "0.927" "1.069" "0.961" "0.973" "1.009" "0.986" "185.2" "175.9" "164.2" "173.5" "171.8" "197.9" "178.0" "180.3" "186.9" "182.7" "" "" "" "" "" "" "" "" "" "" "173.6" "145.5" "152.4" "134.1" "146.4" "189.1" "162.7" "160.1" "186.9" "175.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8451694186259982559" "False" "High" "IsMasterProtein" "Q86W92" "Liprin-beta-1 OS=Homo sapiens OX=9606 GN=PPFIBP1 PE=1 SV=2" "0.000" "False" "7.221" "2" "2" "2" "2" "1011" "114.0" "5.55" "6.36" "2" "cell adhesion;cell organization and biogenesis" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf00536, Pf07647" "8496" "ENSG00000110841" "PPFIBP1" "hsa:8496; O75336; Q86W92; Q86X70; Q9NY03; Q9ULJ0" "" "Signaling by ALK fusions and activated point mutants; Receptor-type tyrosine-protein phosphatases" "2" "0" "1.356" "0.923" "1.292" "1.284" "1.059" "1.137" "1.072" "0.936" "0.822" "37.0" "50.2" "34.2" "47.8" "47.6" "39.2" "42.1" "39.7" "34.7" "30.4" "" "" "" "" "" "" "" "" "" "" "34.7" "41.6" "31.7" "37.0" "40.5" "37.5" "38.5" "35.2" "34.7" "29.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8027894993262294813" "False" "High" "IsMasterProtein" "Q13131" "5'-AMP-activated protein kinase catalytic subunit alpha-1 OS=Homo sapiens OX=9606 GN=PRKAA1 PE=1 SV=4" "0.000" "False" "7.219" "4" "2" "3" "2" "559" "64.0" "8.12" "6.37" "2" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf16579, Pf21147" "5562" "ENSG00000132356" "PRKAA1" "A8MTQ6; B2R7E1; hsa:5562; O00286; Q13131; Q5D0E1; Q86VS1; Q9UNQ4" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Energy metabolism; Thyroxine (thyroid hormone) production; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; mir-124 predicted interactions with cell cycle and differentiation ; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin; Lipid metabolism pathway; PI3K-Akt signaling pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Insulin signaling; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Pleural mesothelioma; Affected pathways in Duchenne muscular dystrophy; ADHD and autism (ASD) linked metabolic pathways and SNP" "Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "36" "0" "1.120" "1.020" "1.091" "1.026" "1.041" "1.027" "1.026" "0.993" "1.026" "235.8" "264.0" "240.6" "257.3" "242.0" "245.6" "242.2" "241.9" "234.3" "241.9" "" "" "" "" "" "" "" "" "" "" "221.0" "218.5" "223.4" "198.9" "206.3" "234.6" "221.3" "214.8" "234.3" "232.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3187719389386559931" "False" "High" "IsMasterProtein" "Q9Y2V2" "Calcium-regulated heat-stable protein 1 OS=Homo sapiens OX=9606 GN=CARHSP1 PE=1 SV=2" "0.000" "False" "7.219" "23" "3" "3" "3" "147" "15.9" "8.21" "9.94" "3" "signal transduction;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00313" "23589" "ENSG00000153048" "CARHSP1" "B2R4C3; D3DUF5; hsa:23589; Q2YDX5; Q9BQ53; Q9Y2V2" "" "" "0" "0" "1.244" "1.125" "1.034" "0.941" "0.968" "0.999" "1.077" "1.119" "1.060" "230.6" "286.7" "259.3" "238.4" "217.1" "223.2" "230.2" "248.2" "258.0" "244.4" "" "" "" "" "" "" "" "" "" "" "216.0" "237.2" "240.8" "184.3" "185.0" "213.3" "210.4" "220.4" "258.0" "235.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8182350314247288702" "False" "High" "IsMasterProtein" "Q9NVQ4" "Fas apoptotic inhibitory molecule 1 OS=Homo sapiens OX=9606 GN=FAIM PE=1 SV=1" "0.000" "False" "7.216" "12" "2" "2" "2" "179" "20.2" "5.83" "7.20" "2" "signal transduction;other biological processes" "other cell component" "" "Pf06905" "55179" "ENSG00000158234" "FAIM" "hsa:55179; Q6IAN2; Q9NVQ4" "Neurogenesis regulation in the olfactory epithelium" "" "1" "0" "0.869" "0.999" "0.814" "0.923" "0.928" "0.745" "0.988" "1.108" "0.958" "287.8" "250.2" "287.4" "234.3" "265.5" "267.0" "214.5" "284.2" "319.0" "275.8" "" "" "" "" "" "" "" "" "" "" "269.7" "207.0" "266.8" "181.1" "226.3" "255.1" "196.0" "252.3" "319.0" "265.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8644531714570174079" "False" "High" "IsMasterProtein" "Q8WVM0" "Dimethyladenosine transferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=TFB1M PE=1 SV=1" "0.000" "False" "7.213" "12" "4" "4" "4" "346" "39.5" "9.26" "9.62" "4" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00398" "51106" "ENSG00000029639" "TFB1M" "hsa:51106; Q05DR0; Q8WVM0; Q9Y384" "Energy metabolism; Mitochondrial gene expression" "Transcriptional activation of mitochondrial biogenesis; rRNA modification in the mitochondrion" "4" "0" "1.237" "1.128" "1.340" "1.334" "1.105" "1.291" "1.109" "1.165" "1.210" "139.0" "171.9" "156.9" "186.3" "185.5" "153.7" "179.5" "154.2" "161.9" "168.2" "" "" "" "" "" "" "" "" "" "" "130.3" "142.3" "145.6" "144.0" "158.1" "146.8" "164.0" "136.9" "161.9" "162.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3858679499056122524" "False" "High" "IsMasterProtein" "P53370" "Nucleoside diphosphate-linked moiety X motif 6 OS=Homo sapiens OX=9606 GN=NUDT6 PE=1 SV=2" "0.000" "False" "7.210" "6" "2" "2" "2" "316" "35.7" "8.00" "6.96" "2" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00293, Pf18290" "11162" "ENSG00000170917" "NUDT6" "A8K756; hsa:11162; O95097; P53370; Q9UQD9" "" "" "0" "0" "0.956" "0.998" "0.891" "0.965" "0.985" "0.888" "0.929" "0.960" "0.965" "171.7" "164.2" "171.4" "153.0" "165.7" "169.1" "152.5" "159.6" "164.8" "165.6" "" "" "" "" "" "" "" "" "" "" "160.9" "135.9" "159.1" "118.3" "141.3" "161.6" "139.4" "141.7" "164.8" "159.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7381193083052724868" "False" "High" "IsMasterProtein" "Q9Y6R4" "Mitogen-activated protein kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP3K4 PE=1 SV=2" "0.000" "False" "7.206" "2" "4" "6" "3" "1608" "181.6" "6.32" "12.38" "4" "other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069, Pf19431" "4216" "ENSG00000085511" "MAP3K4" "A6H8W0; B7ZLD3; B9EG75; hsa:4216; Q5VTT8; Q5VTT9; Q92612; Q9H408; Q9Y6R4" "MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; G13 signaling pathway; DNA damage response (only ATM dependent)" "" "9" "0" "1.526" "1.181" "1.633" "1.186" "1.112" "1.129" "1.121" "1.165" "1.174" "281.4" "429.4" "332.2" "459.5" "333.7" "312.9" "317.6" "315.5" "327.8" "330.4" "" "" "" "" "" "" "" "" "" "" "263.6" "355.3" "308.4" "355.2" "284.4" "299.0" "290.2" "280.2" "327.8" "318.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1316883428224227619" "False" "High" "IsMasterProtein" "Q8WYQ5" "Microprocessor complex subunit DGCR8 OS=Homo sapiens OX=9606 GN=DGCR8 PE=1 SV=1" "0.000" "False" "7.205" "3" "3" "3" "3" "773" "86.0" "5.95" "10.41" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035" "54487" "ENSG00000128191" "DGCR8" "B2R8G1; hsa:54487; Q6DCB2; Q6MZE9; Q6Y2L0; Q8WYQ5; Q96G39; Q96GP8; Q9H6L8; Q9H6T7; Q9NRW2" "miRNA biogenesis; exRNA mechanism of action and biogenesis; DDX1 as a regulatory component of the Drosha microprocessor; 22q11.2 copy number variation syndrome" "Transcriptional Regulation by MECP2; MicroRNA (miRNA) biogenesis" "6" "0" "1.046" "1.113" "1.086" "1.089" "1.098" "0.983" "1.009" "1.033" "1.081" "828.8" "867.0" "922.2" "900.0" "902.9" "910.1" "815.0" "835.9" "856.4" "896.3" "" "" "" "" "" "" "" "" "" "" "776.5" "717.4" "856.1" "695.7" "769.6" "869.5" "744.7" "742.2" "856.4" "863.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7747450166338589829" "False" "High" "IsMasterProtein" "Q8IUE6" "Histone H2A type 2-B OS=Homo sapiens OX=9606 GN=H2AC21 PE=1 SV=3" "0.000" "False" "7.203" "18" "3" "4" "1" "130" "14.0" "10.89" "11.96" "3" "" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "317772" "ENSG00000184270" "H2AC21" "hsa:317772; Q8IUE6" "" "HCMV Early Events; UCH proteinases; Ub-specific processing proteases; HCMV Late Events; HDACs deacetylate histones; Metalloprotease DUBs; RMTs methylate histone arginines; HATs acetylate histones" "8" "0" "1.119" "1.033" "1.303" "1.240" "1.169" "1.140" "0.943" "0.985" "1.052" "56.8" "63.6" "58.7" "74.0" "70.4" "66.4" "64.8" "53.5" "55.9" "59.8" "" "" "" "" "" "" "" "" "" "" "53.2" "52.6" "54.4" "57.2" "60.0" "63.4" "59.2" "47.5" "55.9" "57.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1355905293603533123" "False" "High" "IsMasterProtein" "Q9Y2Z2" "Protein MTO1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=MTO1 PE=1 SV=2" "0.000" "False" "7.198" "3" "3" "3" "3" "717" "79.9" "8.31" "8.89" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01134, Pf13932, Pf21680" "25821" "ENSG00000135297" "MTO1" "B3KQB5; hsa:25821; Q5SWL2; Q5SWL3; Q5SWL4; Q8NDN7; Q8WZ57; Q96FE6; Q9BS06; Q9Y2Z2" "" "tRNA modification in the mitochondrion" "1" "0" "0.989" "0.980" "1.059" "1.046" "1.018" "1.160" "0.977" "1.032" "1.014" "90.2" "89.2" "88.4" "95.5" "94.3" "91.8" "104.6" "88.1" "93.1" "91.5" "" "" "" "" "" "" "" "" "" "" "84.5" "73.8" "82.1" "73.8" "80.4" "87.7" "95.6" "78.2" "93.1" "88.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2750317325017084074" "False" "High" "IsMasterProtein" "Q12962" "Transcription initiation factor TFIID subunit 10 OS=Homo sapiens OX=9606 GN=TAF10 PE=1 SV=1" "0.000" "False" "7.195" "15" "2" "2" "2" "218" "21.7" "6.57" "12.33" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03540" "6881" "ENSG00000166337" "TAF10" "hsa:6881; O00703; Q12962; Q13175; Q6FH13" "" "Ub-specific processing proteases; HATs acetylate histones; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "11" "0" "1.125" "1.034" "1.340" "1.227" "1.048" "1.228" "1.195" "1.200" "1.207" "68.8" "77.5" "71.2" "92.2" "84.4" "72.1" "84.6" "82.3" "82.6" "83.1" "" "" "" "" "" "" "" "" "" "" "64.5" "64.1" "66.1" "71.3" "72.0" "68.9" "77.3" "73.0" "82.6" "80.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "222321955828462706" "False" "High" "IsMasterProtein" "O00244" "Copper transport protein ATOX1 OS=Homo sapiens OX=9606 GN=ATOX1 PE=1 SV=1" "0.000" "False" "7.184" "40" "3" "4" "3" "68" "7.4" "7.24" "12.31" "3" "stress response;transport;other biological processes" "cytosol" "other molecular function" "Pf00403" "475" "ENSG00000177556" "ATOX1" "A8KAJ8; D3DQI2; hsa:475; O00244; Q2M1R6; Q56AP3" "Copper homeostasis" "Detoxification of Reactive Oxygen Species; Ion influx/efflux at host-pathogen interface" "3" "0" "1.068" "1.040" "0.970" "1.007" "1.030" "0.921" "0.994" "0.988" "1.024" "557.2" "595.0" "579.3" "540.6" "560.9" "574.1" "513.2" "554.1" "550.5" "570.4" "" "" "" "" "" "" "" "" "" "" "522.1" "492.4" "537.8" "417.9" "478.1" "548.5" "468.9" "492.0" "550.5" "549.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602671086497481481" "False" "High" "IsMasterProtein" "O43709" "18S rRNA (guanine-N(7))-methyltransferase OS=Homo sapiens OX=9606 GN=BUD23 PE=1 SV=2" "0.000" "False" "7.175" "10" "2" "2" "2" "281" "31.9" "8.73" "8.46" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08241, Pf12589" "114049" "ENSG00000071462" "BUD23" "A8K501; C9K060; hsa:114049; O43709; Q96P12; Q9BQ58; Q9HBP9" "7q11.23 copy number variation syndrome" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "3" "0" "0.993" "1.009" "1.073" "0.998" "0.975" "1.043" "0.995" "0.976" "0.991" "198.0" "196.5" "199.9" "212.4" "197.6" "193.1" "206.5" "197.0" "193.3" "196.3" "" "" "" "" "" "" "" "" "" "" "185.5" "162.6" "185.5" "164.2" "168.4" "184.5" "188.6" "174.9" "193.3" "189.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2350737749617918576" "False" "High" "IsMasterProtein" "Q5TAQ9" "DDB1- and CUL4-associated factor 8 OS=Homo sapiens OX=9606 GN=DCAF8 PE=1 SV=1" "0.000" "False" "7.173" "5" "3" "3" "3" "597" "66.8" "5.39" "5.54" "3" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf00400" "50717" "ENSG00000132716" "DCAF8" "D3DVE6; hsa:50717; Q12839; Q4QQI6; Q53F14; Q5TAQ9; Q66K50; Q68CS7; Q96E00" "" "Neddylation" "1" "0" "0.937" "1.049" "0.857" "0.932" "1.062" "0.875" "0.978" "0.946" "1.015" "361.9" "339.1" "379.8" "310.2" "337.4" "384.2" "316.9" "353.9" "342.3" "367.4" "" "" "" "" "" "" "" "" "" "" "339.1" "280.6" "352.6" "239.8" "287.6" "367.1" "289.5" "314.2" "342.3" "353.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4596787228496680093" "False" "High" "IsMasterProtein" "Q9BV86" "N-terminal Xaa-Pro-Lys N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=NTMT1 PE=1 SV=3" "0.000" "False" "7.165" "7" "3" "3" "3" "223" "25.4" "5.52" "9.86" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05891" "28989" "ENSG00000148335" "NTMT1" "A8K4J2; A8K8G7; hsa:28989; Q5SZB9; Q9BV86; Q9UI28" "" "" "0" "0" "0.981" "0.897" "0.940" "0.941" "0.989" "0.875" "0.888" "1.010" "1.006" "585.5" "574.1" "525.2" "550.6" "551.1" "579.3" "512.6" "520.0" "591.4" "589.1" "" "" "" "" "" "" "" "" "" "" "548.6" "475.1" "487.6" "425.6" "469.7" "553.5" "468.4" "461.7" "591.4" "567.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7864399280568064191" "False" "High" "IsMasterProtein" "Q9BT23" "LIM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=LIMD2 PE=1 SV=1" "0.000" "False" "7.164" "14" "2" "2" "2" "127" "14.1" "9.03" "6.82" "2" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00412" "80774" "ENSG00000136490" "LIMD2" "D3DU16; hsa:80774; Q96S91; Q9BT23" "" "" "0" "0" "1.215" "1.036" "1.057" "1.010" "1.098" "1.075" "1.058" "1.036" "1.076" "345.8" "420.0" "358.3" "365.5" "349.4" "379.8" "371.6" "365.8" "358.2" "372.2" "" "" "" "" "" "" "" "" "" "" "324.0" "347.5" "332.6" "282.5" "297.8" "362.9" "339.6" "324.8" "358.2" "358.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5589324606331654897" "False" "High" "IsMasterProtein" "Q6P161" "Large ribosomal subunit protein mL54 OS=Homo sapiens OX=9606 GN=MRPL54 PE=1 SV=1" "0.000" "False" "7.163" "14" "2" "3" "2" "138" "15.8" "9.60" "9.65" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf08561" "116541" "ENSG00000183617" "MRPL54" "hsa:116541; Q6P161" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.015" "0.895" "0.960" "1.007" "0.983" "0.867" "1.016" "0.959" "0.923" "539.2" "547.5" "482.4" "517.3" "543.0" "530.0" "467.6" "547.6" "516.9" "497.8" "" "" "" "" "" "" "" "" "" "" "505.2" "453.0" "447.8" "399.9" "462.8" "506.4" "427.3" "486.2" "516.9" "479.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3431457210334272148" "False" "High" "IsMasterProtein" "Q75QN2" "Integrator complex subunit 8 OS=Homo sapiens OX=9606 GN=INTS8 PE=1 SV=1" "0.000" "False" "7.160" "4" "3" "3" "3" "995" "113.0" "7.05" "7.94" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "" "55656" "ENSG00000164941" "INTS8" "B2RN92; hsa:55656; Q5RKZ3; Q6P1R5; Q75QN2; Q7Z314; Q9NVS6; Q9NWY7" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "197200824509217859" "False" "High" "IsMasterProtein" "P31040" "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHA PE=1 SV=2" "0.000" "False" "7.155" "3" "2" "2" "2" "664" "72.6" "7.39" "7.88" "2" "other metabolic processes;developmental processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00890, Pf02910" "6389" "ENSG00000073578" "SDHA" "A8K5J6; B4DJ60; E9PBJ5; hsa:6389; P31040; Q16395; Q59GW8; Q8IW48; Q9UMY5" "Electron transport chain: OXPHOS system in mitochondria; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; Arsenic metabolism and reactive oxygen species generation; TCA cycle (aka Krebs or citric acid cycle)" "Respiratory electron transport; Citric acid cycle (TCA cycle)" "9" "0" "1.005" "0.944" "0.983" "0.971" "1.123" "0.882" "1.024" "1.007" "1.056" "253.0" "254.4" "238.7" "248.8" "245.6" "284.3" "223.1" "259.1" "254.8" "267.2" "" "" "" "" "" "" "" "" "" "" "237.1" "210.5" "221.6" "192.3" "209.4" "271.6" "203.9" "230.1" "254.8" "257.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3811066710026793793" "False" "High" "IsMasterProtein" "P21580" "Tumor necrosis factor alpha-induced protein 3 OS=Homo sapiens OX=9606 GN=TNFAIP3 PE=1 SV=1" "0.000" "False" "7.152" "3" "3" "4" "3" "790" "89.6" "8.22" "10.29" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01754, Pf02338" "7128" "ENSG00000118503" "TNFAIP3" "B2R767; E1P588; hsa:7128; P21580; Q2HIX9; Q5VXQ7; Q9NSR6" "TNF-alpha signaling pathway; Vitamin D receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Measles virus infection; IL-18 signaling pathway; Burn wound healing; Modulators of TCR signaling and T cell activation" "NOD1/2 Signaling Pathway; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases; TNFR1-induced proapoptotic signaling" "14" "0" "0.921" "0.961" "0.924" "0.980" "1.011" "0.894" "0.908" "0.896" "0.950" "527.9" "486.4" "507.3" "487.9" "517.2" "533.6" "471.9" "479.3" "473.1" "501.7" "" "" "" "" "" "" "" "" "" "" "494.7" "402.5" "470.9" "377.1" "440.8" "509.8" "431.1" "425.6" "473.1" "483.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6300186880546044127" "False" "High" "IsMasterProtein" "O94829" "Importin-13 OS=Homo sapiens OX=9606 GN=IPO13 PE=1 SV=3" "0.000" "False" "7.150" "3" "3" "3" "3" "963" "108.1" "5.30" "5.69" "3" "transport" "nucleus;other cell component" "other molecular function" "Pf03810, Pf08389, Pf18773, Pf18786, Pf18806" "9670" "ENSG00000117408" "IPO13" "D3DPY4; hsa:9670; O94829; Q5T4X3; Q7LC04; Q96HS3; Q9H8N3; Q9UFR1" "" "" "0" "0" "1.049" "0.993" "1.021" "1.045" "1.057" "0.961" "1.065" "0.971" "1.049" "419.3" "440.0" "416.3" "428.0" "438.1" "443.1" "402.8" "446.5" "407.2" "439.7" "" "" "" "" "" "" "" "" "" "" "392.8" "364.1" "386.4" "330.9" "373.5" "423.4" "368.0" "396.4" "407.2" "423.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1844756928667547842" "False" "High" "IsMasterProtein" "Q9NWU1" "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial OS=Homo sapiens OX=9606 GN=OXSM PE=1 SV=1" "0.000" "False" "7.149" "6" "2" "2" "2" "459" "48.8" "7.66" "6.51" "2" "other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00109, Pf02801" "54995" "ENSG00000151093" "OXSM" "Q9NWU1" "Mitochondrial fatty acid synthesis pathway" "Mitochondrial protein degradation" "2" "0" "1.019" "1.107" "1.050" "1.028" "1.104" "0.972" "1.106" "1.129" "1.132" "233.7" "238.2" "258.7" "245.5" "240.3" "258.1" "227.2" "258.5" "263.9" "264.6" "" "" "" "" "" "" "" "" "" "" "219.0" "197.1" "240.2" "189.8" "204.8" "246.6" "207.6" "229.5" "263.9" "254.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8138947424293882527" "False" "High" "IsMasterProtein" "Q8WV60" "Pentatricopeptide repeat-containing protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=PTCD2 PE=1 SV=3" "0.000" "False" "7.148" "6" "3" "4" "3" "388" "43.9" "9.23" "10.87" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "mitochondrion" "" "Pf10037" "79810" "ENSG00000049883" "PTCD2" "B7Z5D0; B7Z8L7; E9PFV7; hsa:79810; Q6IA65; Q8WV60; Q9H9R0" "" "" "0" "0" "0.982" "1.056" "0.960" "0.995" "1.071" "1.080" "1.019" "1.009" "1.094" "203.8" "200.1" "215.2" "195.7" "202.8" "218.3" "220.1" "207.7" "205.7" "223.0" "" "" "" "" "" "" "" "" "" "" "190.9" "165.6" "199.8" "151.3" "172.9" "208.6" "201.1" "184.4" "205.7" "214.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1820154667624248039" "False" "High" "IsMasterProtein" "P54098" "DNA polymerase subunit gamma-1 OS=Homo sapiens OX=9606 GN=POLG PE=1 SV=1" "0.000" "False" "7.147" "2" "2" "2" "2" "1239" "139.5" "6.90" "8.41" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf18136" "5428" "ENSG00000140521" "POLG" "hsa:5428; P54098; Q8NFM2; Q92515" "Male infertility; Primary ovarian insufficiency" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "843171063376576291" "False" "High" "IsMasterProtein" "Q6P0Q8" "Microtubule-associated serine/threonine-protein kinase 2 OS=Homo sapiens OX=9606 GN=MAST2 PE=1 SV=2" "0.000" "False" "7.145" "2" "3" "3" "2" "1798" "196.3" "8.16" "8.20" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08926, Pf17820" "23139" "ENSG00000086015" "MAST2" "hsa:23139; O94899; Q5VT07; Q5VT08; Q6P0Q8; Q7LGC4; Q8NDG1; Q96B94; Q9BYE8" "" "" "0" "0" "1.053" "0.985" "0.915" "0.912" "0.786" "0.891" "0.885" "0.857" "1.059" "50.3" "53.0" "49.6" "46.1" "45.9" "39.6" "44.8" "44.5" "43.1" "53.3" "" "" "" "" "" "" "" "" "" "" "47.2" "43.8" "46.0" "35.6" "39.1" "37.8" "41.0" "39.5" "43.1" "51.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7524352490741382419" "False" "High" "IsMasterProtein" "O14972" "Vacuolar protein sorting-associated protein 26C OS=Homo sapiens OX=9606 GN=VPS26C PE=1 SV=1" "0.000" "False" "7.137" "13" "3" "3" "3" "297" "33.0" "7.68" "7.58" "3" "transport" "other cytoplasmic organelle" "" "Pf03643" "10311" "ENSG00000157538" "VPS26C" "B2R6T8; B7Z6B1; D3DSH4; hsa:10311; O14972; Q2TAY6" "" "" "0" "0" "1.244" "1.216" "1.281" "1.214" "0.978" "1.232" "1.248" "1.597" "1.113" "64.8" "80.6" "78.8" "82.9" "78.6" "63.3" "79.8" "80.8" "103.4" "72.1" "" "" "" "" "" "" "" "" "" "" "60.7" "66.7" "73.1" "64.1" "67.0" "60.5" "72.9" "71.8" "103.4" "69.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5403362594162546688" "False" "High" "IsMasterProtein" "Q15007" "Pre-mRNA-splicing regulator WTAP OS=Homo sapiens OX=9606 GN=WTAP PE=1 SV=2" "0.000" "False" "7.134" "7" "3" "3" "3" "396" "44.2" "5.19" "10.79" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf17098" "9589" "ENSG00000146457" "WTAP" "hsa:9589; Q15007; Q5TCL8; Q5TCL9; Q96T28; Q9BYJ7; Q9H4E2" "" "Processing of Capped Intron-Containing Pre-mRNA" "1" "0" "0.930" "0.938" "0.977" "0.987" "1.002" "1.213" "1.188" "1.236" "1.085" "1167.1" "1084.9" "1094.5" "1139.9" "1152.4" "1169.9" "1415.5" "1386.6" "1442.7" "1266.8" "" "" "" "" "" "" "" "" "" "" "1093.5" "897.7" "1016.1" "881.2" "982.3" "1117.7" "1293.3" "1231.1" "1442.7" "1219.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7375312169873933341" "False" "High" "IsMasterProtein" "Q92564" "DCN1-like protein 4 OS=Homo sapiens OX=9606 GN=DCUN1D4 PE=1 SV=2" "0.000" "False" "7.131" "8" "3" "5" "2" "292" "34.0" "5.88" "12.15" "3" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03556" "23142" "ENSG00000109184" "DCUN1D4" "B4DH25; hsa:23142; Q7Z3F3; Q7Z6B8; Q92564" "" "Neddylation" "1" "1" "0.988" "0.977" "0.971" "0.970" "0.963" "0.934" "0.975" "0.947" "0.972" "858.1" "848.0" "838.3" "833.2" "832.0" "826.0" "801.2" "836.3" "812.5" "834.1" "" "" "" "" "" "" "" "" "" "" "804.1" "701.7" "778.2" "644.1" "709.1" "789.2" "732.1" "742.5" "812.5" "803.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8481325661535348808" "False" "High" "IsMasterProtein" "P46019" "Phosphorylase b kinase regulatory subunit alpha, liver isoform OS=Homo sapiens OX=9606 GN=PHKA2 PE=1 SV=1" "0.000" "False" "7.130" "2" "3" "5" "3" "1235" "138.3" "6.44" "13.02" "3" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00723, Pf19292" "5256" "ENSG00000044446" "PHKA2" "A8K1T1; hsa:5256; P46019; Q6LAJ5; Q7Z6W0; Q96CR3; Q9UDA1" "Type II diabetes mellitus; Glycogen synthesis and degradation" "Glycogen breakdown (glycogenolysis)" "3" "0" "0.962" "1.033" "1.078" "1.038" "1.060" "0.972" "1.013" "0.966" "0.968" "465.3" "447.6" "480.5" "501.4" "483.1" "493.1" "452.3" "471.1" "449.5" "450.5" "" "" "" "" "" "" "" "" "" "" "436.0" "370.4" "446.1" "387.6" "411.8" "471.1" "413.3" "418.3" "449.5" "433.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7909778503156322818" "False" "High" "IsMasterProtein" "Q96J02" "E3 ubiquitin-protein ligase Itchy homolog OS=Homo sapiens OX=9606 GN=ITCH PE=1 SV=2" "0.000" "False" "7.130" "3" "3" "3" "2" "903" "102.7" "6.30" "3.16" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00168, Pf00397, Pf00632" "83737" "ENSG00000078747" "ITCH" "A6NEW4; B4E234; E1P5P3; F5H217; hsa:83737; O43584; Q5QP37; Q5TEL0; Q96F66; Q96J02; Q9BY75; Q9H451; Q9H4U5" "TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; 10q11.21q11.23 copy number variation syndrome; Notch signaling pathway" "Antigen processing: Ubiquitination & Proteasome degradation; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Activated NOTCH1 Transmits Signal to the Nucleus; Regulation of necroptotic cell death; NOD1/2 Signaling Pathway; Negative regulators of DDX58/IFIH1 signaling; SARS-CoV-1 activates/modulates innate immune responses; Downregulation of ERBB4 signaling" "16" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6678202250508335411" "False" "High" "IsMasterProtein" "Q96CS2" "HAUS augmin-like complex subunit 1 OS=Homo sapiens OX=9606 GN=HAUS1 PE=1 SV=1" "0.000" "False" "7.127" "6" "2" "3" "2" "278" "31.8" "5.53" "9.89" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "" "115106" "ENSG00000152240" "HAUS1" "B2RDM7; hsa:115106; Q8N837; Q96CS2" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "1.038" "0.992" "1.069" "1.037" "1.088" "1.016" "1.031" "1.027" "1.069" "747.1" "775.9" "741.3" "799.0" "774.8" "812.9" "759.3" "770.0" "767.5" "798.9" "" "" "" "" "" "" "" "" "" "" "700.1" "642.0" "688.2" "617.7" "660.4" "776.6" "693.8" "683.7" "767.5" "769.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1100964520603987926" "False" "High" "IsMasterProtein" "Q13825" "Methylglutaconyl-CoA hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=AUH PE=1 SV=1" "0.000" "False" "7.116" "8" "3" "4" "3" "339" "35.6" "9.48" "8.36" "3" "other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00378" "549" "ENSG00000148090" "AUH" "B1ALV7; B1ALV8; hsa:549; Q13825; Q8WUE4" "Amino acid metabolism" "Branched-chain amino acid catabolism" "2" "0" "0.919" "0.988" "1.095" "1.013" "0.990" "0.996" "0.989" "0.970" "0.985" "230.7" "212.1" "228.0" "252.6" "233.8" "228.4" "229.9" "228.2" "223.7" "227.3" "" "" "" "" "" "" "" "" "" "" "216.2" "175.5" "211.7" "195.3" "199.3" "218.2" "210.0" "202.6" "223.7" "218.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-832536973652725080" "False" "High" "IsMasterProtein" "Q96C90" "Protein phosphatase 1 regulatory subunit 14B OS=Homo sapiens OX=9606 GN=PPP1R14B PE=1 SV=3" "0.000" "False" "7.095" "17" "2" "2" "2" "147" "15.9" "4.86" "11.86" "2" "stress response;other biological processes" "other cell component" "enzyme regulator activity" "Pf05361" "26472" "ENSG00000173457" "PPP1R14B" "hsa:26472; Q504S7; Q7KZD7; Q96C90" "" "" "0" "0" "1.091" "0.988" "1.097" "1.083" "0.891" "0.977" "1.026" "1.033" "1.062" "145.6" "158.8" "143.8" "159.7" "157.7" "129.8" "142.3" "149.4" "150.5" "154.7" "" "" "" "" "" "" "" "" "" "" "136.4" "131.4" "133.5" "123.5" "134.4" "124.0" "130.0" "132.6" "150.5" "148.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1297378894876740813" "False" "High" "IsMasterProtein" "Q16854" "Deoxyguanosine kinase, mitochondrial OS=Homo sapiens OX=9606 GN=DGUOK PE=1 SV=2" "0.000" "False" "7.085" "9" "3" "4" "3" "277" "32.0" "8.66" "10.99" "3" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf01712" "1716" "ENSG00000114956" "DGUOK" "hsa:1716; P78532; Q16759; Q16854; Q4ZG09; Q7L1W9; Q96BC1" "Genetic causes of porto-sinusoidal vascular disease" "Purine salvage" "2" "0" "1.065" "1.211" "1.261" "1.164" "1.217" "1.193" "1.107" "1.146" "1.186" "255.8" "272.6" "309.9" "322.7" "297.7" "311.3" "305.3" "283.2" "293.1" "303.4" "" "" "" "" "" "" "" "" "" "" "239.7" "225.6" "287.7" "249.5" "253.7" "297.4" "279.0" "251.4" "293.1" "292.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8567537084386512250" "False" "High" "IsMasterProtein" "P20933" "N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase OS=Homo sapiens OX=9606 GN=AGA PE=1 SV=2" "0.000" "False" "7.065" "8" "3" "3" "3" "346" "37.2" "6.28" "7.83" "3" "protein metabolism;other metabolic processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01112" "175" "ENSG00000038002" "AGA" "B2R7H2; D3DP47; hsa:175; P20933; Q4W5Q2; Q6FHN6; Q9UCK6; Q9UCK7; Q9UCK8" "" "Neutrophil degranulation" "1" "0" "1.052" "0.953" "0.967" "0.995" "0.938" "0.948" "0.964" "0.849" "0.953" "772.8" "812.8" "736.1" "747.3" "768.8" "724.5" "732.4" "745.3" "655.7" "736.3" "" "" "" "" "" "" "" "" "" "" "724.1" "672.6" "683.4" "577.7" "655.3" "692.2" "669.3" "661.7" "655.7" "708.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7576876112341409561" "False" "High" "IsMasterProtein" "O43813" "Glutathione S-transferase LANCL1 OS=Homo sapiens OX=9606 GN=LANCL1 PE=1 SV=1" "0.000" "False" "7.064" "7" "3" "4" "3" "399" "45.3" "7.75" "9.99" "3" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05147" "10314" "ENSG00000115365" "LANCL1" "hsa:10314; O43813" "" "" "0" "0" "0.962" "0.964" "1.070" "0.992" "0.994" "1.000" "0.994" "0.958" "0.967" "377.0" "362.5" "363.2" "403.5" "374.0" "374.6" "376.9" "374.8" "361.2" "364.6" "" "" "" "" "" "" "" "" "" "" "353.2" "300.0" "337.2" "311.9" "318.8" "357.9" "344.4" "332.8" "361.2" "351.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1007819713485126010" "False" "High" "IsMasterProtein" "P83916" "Chromobox protein homolog 1 OS=Homo sapiens OX=9606 GN=CBX1 PE=1 SV=1" "0.000" "False" "7.061" "15" "2" "6" "1" "185" "21.4" "4.93" "23.03" "2" "cell organization and biogenesis;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00385, Pf01393" "10951" "ENSG00000108468" "CBX1" "hsa:10951; P23197; P83916" "Effect of progerin on genes involved in progeria" "HCMV Early Events" "2" "0" "0.891" "1.078" "1.036" "1.138" "1.102" "1.220" "1.105" "1.087" "1.226" "119.4" "106.4" "128.8" "123.7" "135.9" "131.6" "145.6" "131.9" "129.8" "146.4" "" "" "" "" "" "" "" "" "" "" "111.9" "88.1" "119.5" "95.6" "115.8" "125.7" "133.1" "117.1" "129.8" "140.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8727669707947595879" "False" "High" "IsMasterProtein" "Q15058" "Kinesin-like protein KIF14 OS=Homo sapiens OX=9606 GN=KIF14 PE=1 SV=1" "0.000" "False" "7.057" "2" "3" "3" "3" "1648" "186.4" "7.91" "7.87" "3" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf00498, Pf16183" "9928" "ENSG00000118193" "KIF14" "hsa:9928; Q14CI8; Q15058; Q4G0A5; Q5T1W3" "" "RND2 GTPase cycle; RND1 GTPase cycle; RHO GTPases activate CIT" "3" "0" "0.938" "1.005" "1.135" "1.054" "0.969" "1.093" "1.008" "1.000" "1.032" "347.0" "325.7" "348.7" "393.9" "365.6" "336.3" "379.2" "349.7" "347.1" "358.2" "" "" "" "" "" "" "" "" "" "" "325.2" "269.5" "323.7" "304.5" "311.6" "321.3" "346.5" "310.5" "347.1" "344.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5119048535094086908" "False" "High" "IsMasterProtein" "P82912" "Small ribosomal subunit protein uS11m OS=Homo sapiens OX=9606 GN=MRPS11 PE=1 SV=2" "0.000" "False" "7.053" "16" "2" "2" "2" "194" "20.6" "10.81" "2.22" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00411" "64963" "ENSG00000181991" "MRPS11" "B2RD52; hsa:64963; P82912; Q969D7; Q96GI3; Q9BYC3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8365125981762301712" "False" "High" "IsMasterProtein" "P52739" "Zinc finger protein 131 OS=Homo sapiens OX=9606 GN=ZNF131 PE=1 SV=2" "0.000" "False" "7.033" "4" "2" "2" "2" "623" "71.4" "5.19" "6.36" "2" "other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf00651, Pf12874" "7690" "ENSG00000172262" "ZNF131" "B4DRL3; hsa:7690; P52739; Q6PIF0" "" "SUMOylation of transcription cofactors" "1" "0" "1.037" "0.865" "0.819" "0.869" "0.776" "0.727" "0.774" "0.856" "0.893" "86.6" "89.9" "75.0" "70.9" "75.3" "67.2" "63.0" "67.1" "74.2" "77.4" "" "" "" "" "" "" "" "" "" "" "81.2" "74.4" "69.6" "54.8" "64.2" "64.2" "57.5" "59.6" "74.2" "74.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7653373487496169859" "False" "High" "IsMasterProtein" "Q4VC05" "B-cell CLL/lymphoma 7 protein family member A OS=Homo sapiens OX=9606 GN=BCL7A PE=1 SV=1" "0.000" "False" "7.023" "10" "2" "2" "2" "210" "22.8" "5.14" "7.38" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf04714" "605" "ENSG00000110987" "BCL7A" "B4DJN6; B7ZB21; hsa:605; Q13843; Q14CT7; Q4VC05" "" "" "0" "0" "0.987" "0.942" "0.902" "0.914" "0.894" "0.883" "0.846" "0.864" "0.949" "738.8" "728.8" "695.9" "666.5" "675.0" "660.1" "652.4" "625.3" "638.0" "701.2" "" "" "" "" "" "" "" "" "" "" "692.2" "603.1" "646.1" "515.2" "575.4" "630.7" "596.1" "555.2" "638.0" "675.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1641780535886565556" "False" "High" "IsMasterProtein" "Q7L1T6" "Cytochrome b5 reductase 4 OS=Homo sapiens OX=9606 GN=CYB5R4 PE=1 SV=1" "0.000" "False" "7.019" "7" "3" "4" "3" "521" "59.4" "7.72" "12.75" "3" "cell-cell signaling;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00173, Pf00175, Pf00970, Pf04969" "51167" "ENSG00000065615" "CYB5R4" "B1AEM2; hsa:51167; Q5TGI9; Q7L1T6; Q9NUE4; Q9UHI9" "Oxidation by cytochrome P450" "Erythrocytes take up carbon dioxide and release oxygen" "2" "0" "0.866" "0.984" "1.049" "1.062" "1.040" "1.031" "0.936" "1.022" "1.074" "161.9" "140.2" "159.3" "169.8" "171.9" "168.3" "166.8" "151.5" "165.4" "173.8" "" "" "" "" "" "" "" "" "" "" "151.7" "116.1" "147.9" "131.3" "146.5" "160.8" "152.4" "134.5" "165.4" "167.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8349989266333908893" "False" "High" "IsMasterProtein" "P49841" "Glycogen synthase kinase-3 beta OS=Homo sapiens OX=9606 GN=GSK3B PE=1 SV=2" "0.000" "False" "7.018" "7" "2" "2" "1" "420" "46.7" "8.78" "9.48" "2" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "2932" "ENSG00000082701" "GSK3B" "D3DN89; hsa:2932; P49841; Q9BWH3; Q9UL47" "IL-5 signaling pathway; Androgen receptor signaling pathway; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Cell cycle; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; IL-17 signaling pathway; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Focal adhesion; Copper homeostasis; Melatonin metabolism and effects; Wnt signaling pathway; IL6 signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Regulation of apoptosis by parathyroid hormone-related protein; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Wnt signaling pathway and pluripotency; PI3K/AKT/mTOR - vitamin D3 signaling; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; Acute viral myocarditis; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; NRF2-ARE regulation; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Gastrin signaling pathway; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Influence of laminopathies on Wnt signaling; MAP3K1 role in promoting and blocking gonadal determination; Overlap between signal transduction pathways contributing to LMNA laminopathies; Glycogen synthesis and degradation; Pleural mesothelioma; CCL18 signaling pathway; Alzheimer's disease; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Neurogenesis regulation in the olfactory epithelium; Sildenafil treatment; Macrophage-stimulating protein (MSP) signaling network map; HDAC6 interactions in the central nervous system; Notch signaling pathway; ErbB signaling pathway; DNA damage response (only ATM dependent)" "Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Ubiquitin-dependent degradation of Cyclin D; Regulation of RUNX2 expression and activity; Regulation of HSF1-mediated heat shock response; Constitutive Signaling by AKT1 E17K in Cancer; B-WICH complex positively regulates rRNA expression; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; CRMPs in Sema3A signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; AKT phosphorylates targets in the cytosol; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Maturation of nucleoprotein; Maturation of nucleoprotein" "95" "0" "1.063" "0.935" "1.217" "1.247" "1.102" "0.969" "0.990" "0.927" "1.000" "37.1" "39.4" "34.7" "45.1" "46.2" "40.9" "35.9" "36.7" "34.4" "37.1" "" "" "" "" "" "" "" "" "" "" "34.7" "32.6" "32.2" "34.9" "39.4" "39.0" "32.8" "32.6" "34.4" "35.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9165342661713370894" "False" "High" "IsMasterProtein" "Q969U7" "Proteasome assembly chaperone 2 OS=Homo sapiens OX=9606 GN=PSMG2 PE=1 SV=1" "0.000" "False" "7.014" "11" "3" "5" "3" "264" "29.4" "6.98" "12.03" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf09754" "56984" "ENSG00000128789" "PSMG2" "B0YJB3; hsa:56984; Q6IAH4; Q969U7; Q9NRV1; V9GYH7" "" "" "0" "0" "0.919" "0.996" "1.094" "0.966" "1.026" "1.018" "0.995" "1.074" "1.074" "400.3" "368.0" "398.7" "437.8" "386.8" "410.8" "407.7" "398.5" "429.8" "430.0" "" "" "" "" "" "" "" "" "" "" "375.1" "304.6" "370.1" "338.4" "329.7" "392.5" "372.5" "353.8" "429.8" "414.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6622895814543661851" "False" "High" "IsMasterProtein" "O15504" "Nucleoporin NUP42 OS=Homo sapiens OX=9606 GN=NUP42 PE=1 SV=1" "0.000" "False" "7.012" "6" "3" "3" "3" "423" "44.8" "9.19" "8.92" "3" "transport" "other membranes;cytosol;nucleus" "other molecular function" "Pf18044" "11097" "ENSG00000136243" "NUP42" "A4D143; B4DP42; hsa:11097; O15504; Q49AE7; Q9BS49" "" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "28" "0" "0.966" "1.018" "1.111" "1.073" "1.063" "0.988" "1.035" "1.122" "1.074" "134.7" "130.0" "137.1" "149.6" "144.5" "143.2" "133.0" "139.4" "151.1" "144.7" "" "" "" "" "" "" "" "" "" "" "126.2" "107.6" "127.3" "115.7" "123.2" "136.8" "121.5" "123.7" "151.1" "139.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2197704674171232077" "False" "High" "IsMasterProtein" "Q52LR7" "Enhancer of polycomb homolog 2 OS=Homo sapiens OX=9606 GN=EPC2 PE=1 SV=2" "0.000" "False" "7.012" "2" "2" "3" "1" "807" "91.0" "8.73" "7.20" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf06752, Pf10513" "26122" "ENSG00000135999" "EPC2" "B3KWT7; D3DP89; hsa:26122; Q52LR7; Q7L9J1; Q96RR7; Q9NUT8; Q9NVR1; Q9UFM9" "" "" "0" "0" "1.056" "0.916" "1.046" "1.045" "1.050" "1.042" "0.985" "1.229" "1.305" "126.9" "133.9" "116.3" "132.7" "132.6" "133.2" "132.2" "125.0" "155.9" "165.6" "" "" "" "" "" "" "" "" "" "" "118.9" "110.8" "107.9" "102.6" "113.0" "127.3" "120.8" "110.9" "155.9" "159.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-710496043913301714" "False" "High" "IsMasterProtein" "Q15714" "TSC22 domain family protein 1 OS=Homo sapiens OX=9606 GN=TSC22D1 PE=1 SV=3" "0.000" "False" "7.003" "2" "3" "3" "1" "1073" "109.6" "5.64" "7.74" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01166" "8848" "ENSG00000102804" "TSC22D1" "A0A087X0H8; B3KRL7; B9EGI0; hsa:8848; O00666; Q15714; Q6AHX5; Q6IBU1; Q8NCN1; Q96JS5" "Ectoderm differentiation; Ectoderm differentiation" "" "2" "0" "1.098" "0.935" "1.035" "1.064" "1.053" "0.958" "0.920" "0.827" "1.050" "214.5" "235.6" "200.5" "222.1" "228.2" "225.9" "205.6" "197.4" "177.5" "225.3" "" "" "" "" "" "" "" "" "" "" "201.0" "194.9" "186.1" "171.7" "194.5" "215.8" "187.8" "175.3" "177.5" "216.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7918100123629271451" "False" "High" "IsMasterProtein" "Q9NWV4" "CXXC motif containing zinc binding protein OS=Homo sapiens OX=9606 GN=CZIB PE=1 SV=1" "0.000" "False" "6.995" "16" "2" "2" "2" "160" "18.0" "5.01" "8.55" "2" "" "" "other molecular function" "Pf05907" "54987" "ENSG00000162384" "CZIB" "hsa:54987; Q9NWV4" "" "" "0" "0" "1.085" "0.941" "1.043" "1.005" "0.975" "1.024" "1.046" "0.963" "1.005" "479.7" "520.4" "451.3" "500.3" "482.0" "467.5" "491.2" "501.8" "462.1" "482.2" "" "" "" "" "" "" "" "" "" "" "449.4" "430.6" "419.0" "386.7" "410.8" "446.7" "448.8" "445.5" "462.1" "464.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1811232654349558643" "False" "High" "IsMasterProtein" "P18846" "Cyclic AMP-dependent transcription factor ATF-1 OS=Homo sapiens OX=9606 GN=ATF1 PE=1 SV=2" "0.000" "False" "6.987" "9" "3" "4" "1" "271" "29.2" "8.37" "14.29" "3" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf02173" "466" "ENSG00000123268" "ATF1" "B4DRF9; hsa:466; P18846; P25168; Q9H4A8" "Integrated cancer pathway; Androgen receptor network in prostate cancer; Interleukin-11 signaling pathway; Myometrial relaxation and contraction pathways; EGF/EGFR signaling pathway; GDNF signaling; Serotonin receptor 4/6/7 and NR3C signaling" "NGF-stimulated transcription; CREB phosphorylation" "9" "0" "0.949" "0.961" "1.010" "1.038" "1.017" "0.913" "1.058" "0.925" "1.033" "96.1" "91.2" "92.4" "97.1" "99.8" "97.8" "87.8" "101.7" "88.9" "99.3" "" "" "" "" "" "" "" "" "" "" "90.1" "75.5" "85.8" "75.0" "85.1" "93.4" "80.2" "90.3" "88.9" "95.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5869827592286108947" "False" "High" "IsMasterProtein" "Q9UPQ9" "Trinucleotide repeat-containing gene 6B protein OS=Homo sapiens OX=9606 GN=TNRC6B PE=1 SV=4" "0.000" "False" "6.984" "1" "2" "2" "2" "1833" "193.9" "6.76" "6.87" "2" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf10427, Pf16608" "23112" "ENSG00000100354" "TNRC6B" "B0QY73; B0QY78; B4DGC0; hsa:23112; Q5TH52; Q8TBX2; Q9UPQ9" "" "Oxidative Stress Induced Senescence; MAPK6/MAPK4 signaling; Estrogen-dependent gene expression; TP53 Regulates Metabolic Genes; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Ca2+ pathway; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "18" "0" "1.017" "0.944" "0.986" "1.127" "1.041" "1.133" "1.004" "1.011" "0.995" "191.9" "195.2" "181.1" "189.1" "216.2" "199.6" "217.3" "192.6" "193.9" "191.0" "" "" "" "" "" "" "" "" "" "" "179.8" "161.5" "168.1" "146.2" "184.3" "190.7" "198.6" "171.0" "193.9" "183.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2936440106232523244" "False" "High" "IsMasterProtein" "Q9NYH9" "U3 small nucleolar RNA-associated protein 6 homolog OS=Homo sapiens OX=9606 GN=UTP6 PE=1 SV=2" "0.000" "False" "6.981" "4" "2" "3" "2" "597" "70.1" "7.28" "9.44" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf08640" "55813" "ENSG00000108651" "UTP6" "hsa:55813; Q8IX96; Q96BL2; Q9NQ91; Q9NYH9" "NF1 copy number variation syndrome" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "3" "0" "1.021" "1.097" "1.266" "1.131" "1.127" "1.167" "1.131" "1.051" "1.165" "362.4" "370.2" "397.5" "458.9" "409.8" "408.4" "423.0" "409.8" "381.0" "422.4" "" "" "" "" "" "" "" "" "" "" "339.6" "306.3" "369.0" "354.7" "349.3" "390.2" "386.5" "363.8" "381.0" "406.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5875198809388005970" "False" "High" "IsMasterProtein" "Q9H3H3" "UPF0696 protein C11orf68 OS=Homo sapiens OX=9606 GN=C11orf68 PE=1 SV=3" "0.000" "False" "6.975" "7" "2" "3" "2" "292" "31.4" "6.32" "11.29" "2" "" "" "" "Pf08939" "83638" "ENSG00000175573" "C11orf68" "hsa:83638; J3KQG9; Q9BT13; Q9H3H3" "" "" "0" "0" "1.068" "0.975" "1.093" "0.989" "0.909" "0.956" "0.946" "0.968" "0.951" "442.9" "473.1" "431.9" "483.9" "437.9" "402.4" "423.6" "419.1" "428.5" "421.3" "" "" "" "" "" "" "" "" "" "" "415.0" "391.5" "401.0" "374.1" "373.2" "384.5" "387.0" "372.1" "428.5" "405.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8485844677282632680" "False" "High" "IsMasterProtein" "Q99717" "Mothers against decapentaplegic homolog 5 OS=Homo sapiens OX=9606 GN=SMAD5 PE=1 SV=1" "0.000" "False" "6.963" "5" "2" "2" "2" "465" "52.2" "7.71" "8.92" "2" "developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4090" "ENSG00000113658" "SMAD5" "hsa:4090; O14688; Q15798; Q99717; Q9UQA1" "Differentiation of white and brown adipocyte; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Neovascularization processes; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Network map of SARS-CoV-2 signaling pathway; Clock-controlled autophagy in bone metabolism; Markers of kidney cell lineage; 10q11.21q11.23 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; TGF-beta receptor signaling" "Signaling by BMP" "14" "0" "1.012" "1.056" "0.972" "0.971" "1.020" "0.968" "0.944" "1.005" "0.989" "105.5" "106.7" "111.3" "102.5" "102.4" "107.6" "102.1" "99.5" "106.0" "104.3" "" "" "" "" "" "" "" "" "" "" "98.8" "88.3" "103.4" "79.2" "87.3" "102.8" "93.3" "88.4" "106.0" "100.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4995074517937679177" "False" "High" "IsMasterProtein" "O95628" "CCR4-NOT transcription complex subunit 4 OS=Homo sapiens OX=9606 GN=CNOT4 PE=1 SV=3" "0.000" "False" "6.962" "4" "3" "3" "3" "575" "63.5" "7.03" "9.72" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00076, Pf14570" "4850" "ENSG00000080802" "CNOT4" "B7Z6I4; E7ET38; F8VQP3; O95339; O95627; O95628; Q8IYM7; Q8NCL0; Q9NPQ1; Q9NZN6" "" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "1.061" "1.018" "1.023" "1.015" "0.991" "0.989" "0.960" "0.943" "0.976" "436.9" "463.5" "444.6" "446.8" "443.5" "432.8" "432.3" "419.4" "412.0" "426.6" "" "" "" "" "" "" "" "" "" "" "409.4" "383.5" "412.8" "345.4" "378.0" "413.5" "395.0" "372.4" "412.0" "410.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5464068146291938331" "False" "High" "IsMasterProtein" "P49840" "Glycogen synthase kinase-3 alpha OS=Homo sapiens OX=9606 GN=GSK3A PE=1 SV=2" "0.000" "False" "6.961" "5" "2" "2" "1" "483" "50.9" "8.75" "9.01" "2" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "2931" "ENSG00000105723" "GSK3A" "hsa:2931; O14959; P49840" "IL-5 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Wnt signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Nonalcoholic fatty liver disease; Insulin signaling; Glycogen synthesis and degradation; HDAC6 interactions in the central nervous system" "Constitutive Signaling by AKT1 E17K in Cancer; XBP1(S) activates chaperone genes; AKT phosphorylates targets in the cytosol; Suppression of apoptosis; Maturation of nucleoprotein; Maturation of nucleoprotein" "18" "1" "1.046" "1.092" "1.069" "1.081" "1.059" "0.989" "1.047" "1.148" "1.018" "365.4" "382.0" "399.1" "390.8" "395.2" "387.1" "361.2" "382.7" "419.5" "371.8" "" "" "" "" "" "" "" "" "" "" "342.4" "316.1" "370.5" "302.1" "336.8" "369.9" "330.1" "339.8" "419.5" "358.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8312562393160644927" "False" "High" "IsMasterProtein" "Q8WV22" "Non-structural maintenance of chromosomes element 1 homolog OS=Homo sapiens OX=9606 GN=NSMCE1 PE=1 SV=5" "0.000" "False" "6.959" "10" "3" "3" "3" "266" "30.8" "7.47" "7.76" "3" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf07574, Pf08746" "197370" "ENSG00000169189" "NSMCE1" "D3DWF6; hsa:197370; Q8WV22; Q9P045; Q9P049" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "1.008" "1.049" "1.127" "1.042" "1.125" "1.032" "1.049" "1.036" "1.070" "387.8" "390.9" "406.8" "437.1" "404.1" "436.3" "400.1" "406.8" "401.9" "415.1" "" "" "" "" "" "" "" "" "" "" "363.4" "323.5" "377.7" "337.9" "344.5" "416.9" "365.6" "361.2" "401.9" "399.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4220399671961536759" "False" "High" "IsMasterProtein" "Q92918" "Mitogen-activated protein kinase kinase kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP4K1 PE=1 SV=1" "0.000" "False" "6.958" "3" "3" "3" "3" "833" "91.2" "8.34" "7.78" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069, Pf00780" "11184" "ENSG00000104814" "MAP4K1" "hsa:11184; Q92918" "Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Cardiac hypertrophic response; Hepatocyte growth factor receptor signaling; TGF-beta signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Modulators of TCR signaling and T cell activation; Pleural mesothelioma; T-cell receptor signaling pathway" "" "14" "0" "0.955" "0.982" "1.063" "0.925" "0.984" "1.067" "0.949" "0.929" "0.983" "161.4" "154.1" "158.4" "171.4" "149.3" "158.7" "172.1" "153.2" "149.9" "158.7" "" "" "" "" "" "" "" "" "" "" "151.2" "127.5" "147.0" "132.5" "127.3" "151.6" "157.3" "136.0" "149.9" "152.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9157929292758815644" "False" "High" "IsMasterProtein" "Q96A35" "Large ribosomal subunit protein uL24m OS=Homo sapiens OX=9606 GN=MRPL24 PE=1 SV=1" "0.000" "False" "6.949" "14" "3" "4" "3" "216" "24.9" "9.29" "11.84" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00467, Pf17136" "79590" "ENSG00000143314" "MRPL24" "D3DVC8; hsa:79590; Q53G65; Q53HT0; Q5SYZ9; Q5SZ00; Q5SZ02; Q96A35; Q96Q70; Q9H7G3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.168" "1.147" "1.050" "1.088" "1.208" "1.027" "1.160" "1.158" "1.104" "133.0" "155.4" "152.6" "139.7" "144.8" "160.7" "136.6" "154.3" "154.0" "146.9" "" "" "" "" "" "" "" "" "" "" "124.6" "128.6" "141.7" "108.0" "123.4" "153.5" "124.8" "137.0" "154.0" "141.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5461850800476976864" "False" "High" "IsMasterProtein" "Q9UBB5" "Methyl-CpG-binding domain protein 2 OS=Homo sapiens OX=9606 GN=MBD2 PE=1 SV=1" "0.000" "False" "6.948" "7" "3" "3" "1" "411" "43.2" "10.04" "9.27" "3" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429, Pf14048, Pf16564" "8932" "ENSG00000134046" "MBD2" "hsa:8932; O95242; Q9UBB5; Q9UIS8" "Effect of progerin on genes involved in progeria" "NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Opening" "3" "0" "1.693" "1.442" "2.073" "1.420" "1.419" "1.631" "1.428" "1.420" "1.395" "25.4" "43.0" "36.6" "52.7" "36.1" "36.0" "41.4" "36.3" "36.1" "35.4" "" "" "" "" "" "" "" "" "" "" "23.8" "35.6" "34.0" "40.7" "30.8" "34.4" "37.9" "32.2" "36.1" "34.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2424139350801194209" "False" "High" "IsMasterProtein" "Q9NRG0" "Chromatin accessibility complex protein 1 OS=Homo sapiens OX=9606 GN=CHRAC1 PE=1 SV=1" "0.000" "False" "6.942" "20" "2" "4" "2" "131" "14.7" "5.10" "15.53" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "54108" "ENSG00000104472" "CHRAC1" "hsa:54108; Q9NRG0" "Acute viral myocarditis" "" "1" "0" "1.114" "0.997" "1.061" "1.106" "1.035" "1.047" "0.964" "0.946" "1.044" "491.6" "547.7" "490.3" "521.6" "543.7" "508.8" "514.5" "473.7" "465.3" "513.4" "" "" "" "" "" "" "" "" "" "" "460.7" "453.2" "455.2" "403.2" "463.4" "486.1" "470.1" "420.6" "465.3" "494.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4561933771637395336" "False" "High" "IsMasterProtein" "Q15329" "Transcription factor E2F5 OS=Homo sapiens OX=9606 GN=E2F5 PE=1 SV=1" "0.000" "False" "6.933" "7" "3" "4" "1" "346" "37.6" "5.10" "9.29" "3" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02319, Pf16421" "1875" "ENSG00000133740" "E2F5" "E9PBN9; hsa:1875; Q15329; Q16601; Q92756" "Cell cycle; Spinal cord injury; Pre-implantation embryo; TGF-beta signaling pathway; DYRK1A involvement regarding cell proliferation in brain development" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Cyclin D associated events in G1; G1/S-Specific Transcription; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8771198256922364078" "False" "High" "IsMasterProtein" "P10244" "Myb-related protein B OS=Homo sapiens OX=9606 GN=MYBL2 PE=1 SV=1" "0.000" "False" "6.931" "3" "2" "2" "2" "700" "78.7" "6.87" "6.83" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf09316, Pf13921" "4605" "ENSG00000101057" "MYBL2" "B2RBS5; B7Z8D9; F8W6N6; hsa:4605; P10244; Q53F07" "Gastric cancer network 1; EGF/EGFR signaling pathway" "Polo-like kinase mediated events; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "5" "0" "1.076" "1.053" "1.015" "1.059" "0.976" "1.035" "1.082" "1.159" "1.018" "246.0" "264.6" "259.1" "249.6" "260.6" "240.1" "254.6" "266.1" "285.0" "250.5" "" "" "" "" "" "" "" "" "" "" "230.5" "219.0" "240.5" "192.9" "222.1" "229.4" "232.6" "236.3" "285.0" "241.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3248682762130005719" "False" "High" "IsMasterProtein" "Q9BQ39" "ATP-dependent RNA helicase DDX50 OS=Homo sapiens OX=9606 GN=DDX50 PE=1 SV=1" "0.000" "False" "6.928" "4" "3" "6" "1" "737" "82.5" "9.17" "19.73" "3" "" "plasma membrane;other membranes;nucleus" "other molecular function" "Pf00270, Pf00271, Pf08152" "79009" "ENSG00000107625" "DDX50" "hsa:79009; Q5VX37; Q8WV76; Q9BQ39; Q9BWI8" "" "" "0" "0" "0.882" "1.005" "1.127" "1.006" "0.990" "1.037" "1.030" "0.852" "1.000" "263.7" "232.6" "265.1" "297.3" "265.4" "261.0" "273.5" "271.7" "224.8" "263.6" "" "" "" "" "" "" "" "" "" "" "247.1" "192.5" "246.1" "229.8" "226.2" "249.4" "249.9" "241.2" "224.8" "253.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4707319533501773453" "False" "High" "IsMasterProtein" "O95260" "Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=2" "0.000" "False" "6.910" "5" "3" "3" "3" "518" "59.1" "7.93" "8.19" "3" "protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04376, Pf04377" "11101" "ENSG00000107669" "ATE1" "hsa:11101; O95260; O95261; Q5SQQ3; Q8WW04" "" "" "0" "0" "1.106" "1.191" "1.036" "1.095" "1.249" "0.981" "0.953" "1.115" "1.094" "85.5" "94.6" "101.8" "88.6" "93.6" "106.8" "83.9" "81.5" "95.3" "93.5" "" "" "" "" "" "" "" "" "" "" "80.1" "78.3" "94.6" "68.5" "79.8" "102.0" "76.7" "72.3" "95.3" "90.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5006297447401564784" "False" "High" "IsMasterProtein" "Q96B23" "Protein ARK2N OS=Homo sapiens OX=9606 GN=ARK2N PE=1 SV=3" "0.000" "False" "6.907" "5" "2" "2" "2" "404" "43.4" "4.88" "7.64" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15303" "147339" "ENSG00000152242" "ARK2N" "A8K123; A8KAB6; hsa:147339; Q5BIX2; Q5XG78; Q6N058; Q86TB5; Q8TCQ5; Q96B23" "" "" "0" "0" "1.125" "1.081" "0.982" "0.985" "1.009" "0.977" "0.957" "1.054" "1.040" "464.1" "522.2" "501.7" "455.6" "457.3" "468.4" "453.7" "444.1" "489.0" "482.5" "" "" "" "" "" "" "" "" "" "" "434.9" "432.1" "465.8" "352.2" "389.8" "447.5" "414.5" "394.4" "489.0" "464.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5314014285931232470" "False" "High" "IsMasterProtein" "P18124" "Large ribosomal subunit protein uL30 OS=Homo sapiens OX=9606 GN=RPL7 PE=1 SV=1" "0.000" "False" "6.904" "8" "2" "2" "2" "248" "29.2" "10.65" "6.55" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00327, Pf08079" "6129" "ENSG00000147604" "RPL7" "A8K504; hsa:6129; P18124; Q15289; Q3KQU0; Q5I0X1; Q6IBM9" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3273487821867758056" "False" "High" "IsMasterProtein" "Q96DV4" "Large ribosomal subunit protein mL38 OS=Homo sapiens OX=9606 GN=MRPL38 PE=1 SV=2" "0.000" "False" "6.894" "7" "3" "3" "3" "380" "44.6" "7.53" "9.07" "3" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "" "Pf01161" "64978" "ENSG00000204316" "MRPL38" "B3KN96; hsa:64978; Q96DV4; Q96Q66; Q9P0B9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.942" "0.969" "1.000" "1.078" "0.996" "0.980" "1.002" "1.030" "1.104" "188.7" "177.7" "182.8" "188.8" "203.5" "188.0" "184.9" "189.0" "194.3" "208.4" "" "" "" "" "" "" "" "" "" "" "176.8" "147.1" "169.7" "145.9" "173.4" "179.6" "168.9" "167.8" "194.3" "200.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5094634281983093833" "False" "High" "IsMasterProtein" "P57723" "Poly(rC)-binding protein 4 OS=Homo sapiens OX=9606 GN=PCBP4 PE=1 SV=1" "0.000" "False" "6.887" "5" "2" "3" "1" "403" "41.5" "8.16" "11.59" "2" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00013, Pf07650" "57060" "ENSG00000090097" "PCBP4" "hsa:57060; P57723; Q96AH7" "" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; FOXO-mediated transcription of cell cycle genes; Transcriptional activation of cell cycle inhibitor p21" "3" "0" "1.042" "0.916" "0.971" "0.953" "0.956" "0.919" "0.912" "0.873" "0.886" "137.8" "143.6" "126.3" "133.8" "131.3" "131.7" "126.6" "125.8" "120.3" "122.2" "" "" "" "" "" "" "" "" "" "" "129.1" "118.8" "117.2" "103.4" "111.9" "125.8" "115.7" "111.7" "120.3" "117.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6256301948778102802" "False" "High" "IsMasterProtein" "Q8NCE0" "tRNA-splicing endonuclease subunit Sen2 OS=Homo sapiens OX=9606 GN=TSEN2 PE=1 SV=2" "0.000" "False" "6.886" "6" "3" "3" "3" "465" "53.2" "7.85" "9.30" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf01974, Pf02778" "80746" "ENSG00000154743" "TSEN2" "B7Z6K1; C9IZI7; G5E9Q3; hsa:80746; Q8NCE0; Q8WTW7; Q9BPU7" "" "tRNA processing in the nucleus" "1" "0" "1.056" "0.992" "1.155" "1.070" "0.990" "0.970" "1.043" "0.962" "0.972" "351.4" "371.1" "348.8" "405.9" "376.0" "348.0" "341.0" "366.4" "338.0" "341.6" "" "" "" "" "" "" "" "" "" "" "329.3" "307.1" "323.8" "313.8" "320.5" "332.5" "311.6" "325.3" "338.0" "328.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3776455647046576995" "False" "High" "IsMasterProtein" "Q7L3B6" "Hsp90 co-chaperone Cdc37-like 1 OS=Homo sapiens OX=9606 GN=CDC37L1 PE=1 SV=1" "0.000" "False" "6.883" "8" "2" "2" "2" "337" "38.8" "5.34" "7.03" "2" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf08565" "55664" "ENSG00000106993" "CDC37L1" "B1AL70; hsa:55664; Q7L3B6; Q9NWS3; Q9NX16" "" "Platelet degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6928651678899214990" "False" "High" "IsMasterProtein" "Q86VM9" "Zinc finger CCCH domain-containing protein 18 OS=Homo sapiens OX=9606 GN=ZC3H18 PE=1 SV=2" "0.000" "False" "6.865" "2" "2" "3" "2" "953" "106.3" "8.32" "11.77" "2" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf18044" "124245" "ENSG00000158545" "ZC3H18" "hsa:124245; Q86VM9; Q96DG4; Q96MP7" "" "" "0" "0" "1.059" "0.990" "1.012" "1.022" "0.872" "1.256" "1.149" "1.097" "1.013" "352.4" "373.0" "348.9" "356.8" "360.1" "307.3" "442.7" "404.9" "386.7" "356.9" "" "" "" "" "" "" "" "" "" "" "330.2" "308.7" "323.9" "275.8" "306.9" "293.6" "404.5" "359.5" "386.7" "343.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8775799832689222428" "False" "High" "IsMasterProtein" "Q8IV38" "Ankyrin repeat and MYND domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ANKMY2 PE=1 SV=1" "0.000" "False" "6.863" "7" "2" "2" "2" "441" "49.3" "6.25" "7.37" "2" "" "other cell component" "other molecular function" "Pf01753, Pf12796" "57037" "ENSG00000106524" "ANKMY2" "A4D124; hsa:57037; Q659G1; Q8IV38; Q96BL3" "" "" "0" "0" "1.270" "1.210" "1.235" "1.377" "1.190" "1.003" "0.950" "1.114" "1.356" "23.1" "29.4" "28.0" "28.6" "31.9" "27.5" "23.2" "22.0" "25.8" "31.4" "" "" "" "" "" "" "" "" "" "" "21.7" "24.3" "26.0" "22.1" "27.2" "26.3" "21.2" "19.5" "25.8" "30.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4031307080017597315" "False" "High" "IsMasterProtein" "P18077" "Large ribosomal subunit protein eL33 OS=Homo sapiens OX=9606 GN=RPL35A PE=1 SV=2" "0.000" "False" "6.862" "21" "3" "3" "3" "110" "12.5" "11.06" "9.52" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01247" "6165" "ENSG00000182899" "RPL35A" "hsa:6165; P18077; Q08ES9; Q9BVN7" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.058" "1.070" "1.110" "1.198" "1.099" "1.201" "1.108" "1.106" "1.185" "472.6" "500.0" "505.7" "524.3" "565.9" "519.5" "567.4" "523.6" "522.7" "560.0" "" "" "" "" "" "" "" "" "" "" "442.8" "413.7" "469.5" "405.3" "482.4" "496.3" "518.5" "464.9" "522.7" "539.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8837747805973553035" "False" "High" "IsMasterProtein" "Q12778" "Forkhead box protein O1 OS=Homo sapiens OX=9606 GN=FOXO1 PE=1 SV=2" "0.000" "False" "6.862" "3" "2" "2" "2" "655" "69.6" "6.77" "7.53" "2" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf16675, Pf16676" "2308" "ENSG00000150907" "FOXO1" "hsa:2308; O43523; Q12778; Q5VYC7; Q6NSK6" "Androgen receptor signaling pathway; Energy metabolism; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; AGE/RAGE pathway; Adipogenesis; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; Copper homeostasis; Melatonin metabolism and effects; RAC1/PAK1/p38/MMP2 pathway; Transcription factor regulation in adipogenesis; NAD metabolism, sirtuins and aging; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; White fat cell differentiation; Somatroph axis (GH) and its relationship to dietary restriction and aging; EGF/EGFR signaling pathway; Leukocyte-intrinsic Hippo pathway functions; Gastrin signaling pathway; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; Kynurenine pathway and links to cell senescence; FOXA2 pathway; Pleural mesothelioma; Interactions of natural killer cells in pancreatic cancer; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Warburg effect modulated by deubiquitinating enzymes and their substrates; Extrafollicular and follicular B cell activation by SARS-CoV-2; Primary ovarian insufficiency; Rubinstein-Taybi syndrome 1; ErbB signaling pathway" "Constitutive Signaling by AKT1 E17K in Cancer; MAPK6/MAPK4 signaling; AKT phosphorylates targets in the nucleus; Regulation of localization of FOXO transcription factors; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Interleukin-4 and Interleukin-13 signaling; FOXO-mediated transcription of cell cycle genes; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; AKT-mediated inactivation of FOXO1A" "52" "0" "1.032" "0.974" "0.916" "0.965" "0.921" "0.870" "0.888" "0.897" "0.962" "567.8" "585.9" "553.2" "520.3" "547.8" "523.2" "494.1" "504.0" "509.4" "546.1" "" "" "" "" "" "" "" "" "" "" "532.0" "484.8" "513.6" "402.2" "466.9" "499.8" "451.5" "447.5" "509.4" "525.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4650231133703774819" "False" "High" "IsMasterProtein" "Q96RF0" "Sorting nexin-18 OS=Homo sapiens OX=9606 GN=SNX18 PE=1 SV=2" "0.000" "False" "6.860" "5" "3" "3" "3" "628" "68.9" "5.68" "9.85" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787, Pf10456, Pf14604" "112574" "ENSG00000178996" "SNX18" "B4E2B3; H7BXX3; hsa:112574; Q05BB3; Q0VG02; Q96RF0" "" "Clathrin-mediated endocytosis" "1" "0" "0.952" "0.963" "1.044" "0.985" "1.002" "0.984" "0.940" "0.887" "0.963" "408.2" "388.5" "393.2" "426.2" "402.2" "409.2" "401.8" "383.8" "362.1" "393.0" "" "" "" "" "" "" "" "" "" "" "382.5" "321.4" "365.0" "329.5" "342.8" "391.0" "367.1" "340.8" "362.1" "378.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1970257073034718295" "False" "High" "IsMasterProtein" "Q6RW13" "Type-1 angiotensin II receptor-associated protein OS=Homo sapiens OX=9606 GN=AGTRAP PE=1 SV=1" "0.000" "False" "6.858" "19" "2" "2" "2" "159" "17.4" "6.14" "7.13" "2" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf06396" "57085" "ENSG00000177674" "AGTRAP" "A8MVQ5; hsa:57085; Q5SNV4; Q5SNV5; Q6RW13; Q96AC0; Q96PL4; Q9NRW9" "" "Signaling by BRAF and RAF1 fusions" "1" "0" "0.956" "0.964" "1.006" "0.922" "0.963" "1.030" "1.007" "0.975" "0.998" "302.8" "289.4" "291.8" "304.6" "279.1" "291.6" "311.7" "304.8" "295.3" "302.1" "" "" "" "" "" "" "" "" "" "" "283.7" "239.5" "270.9" "235.5" "237.9" "278.6" "284.9" "270.6" "295.3" "290.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3423051625263553233" "False" "High" "IsMasterProtein" "Q9BZQ6" "ER degradation-enhancing alpha-mannosidase-like protein 3 OS=Homo sapiens OX=9606 GN=EDEM3 PE=1 SV=2" "0.000" "False" "6.854" "2" "2" "2" "2" "932" "104.6" "4.93" "6.62" "2" "protein metabolism;other metabolic processes;stress response" "other membranes;ER/Golgi" "other molecular function" "Pf01532, Pf02225" "80267" "ENSG00000116406" "EDEM3" "B2RCH6; B7ZLZ2; hsa:80267; Q0VGM5; Q5TEZ0; Q7L2Y5; Q9BZQ6; Q9HCW1; Q9UFV7" "" "ER Quality Control Compartment (ERQC)" "1" "0" "0.931" "0.975" "0.965" "0.947" "0.974" "0.895" "0.885" "0.876" "0.925" "386.4" "359.7" "376.7" "372.8" "365.8" "376.2" "345.8" "341.9" "338.4" "357.5" "" "" "" "" "" "" "" "" "" "" "362.0" "297.7" "349.7" "288.2" "311.8" "359.4" "316.0" "303.6" "338.4" "344.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5375440904508103637" "False" "High" "IsMasterProtein" "Q6ZSJ8" "Uncharacterized protein C1orf122 OS=Homo sapiens OX=9606 GN=C1orf122 PE=1 SV=2" "0.000" "False" "6.854" "18" "2" "3" "2" "110" "11.5" "6.73" "7.42" "2" "" "" "" "Pf15855" "127687" "ENSG00000197982" "C1orf122" "A2RQF4; E9PQ13; hsa:127687; Q56A71; Q6ZSJ8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8678565654600364554" "False" "High" "IsMasterProtein" "Q8WWV3" "Reticulon-4-interacting protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=RTN4IP1 PE=1 SV=2" "0.000" "False" "6.853" "5" "2" "2" "2" "396" "43.6" "9.11" "7.18" "2" "developmental processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf08240, Pf13602" "84816" "ENSG00000130347" "RTN4IP1" "hsa:84816; Q8N9B3; Q8WWV3; Q8WZ66; Q9BRA4" "" "" "0" "0" "1.049" "1.027" "1.038" "1.009" "1.055" "1.040" "1.026" "1.009" "1.073" "550.7" "577.7" "565.3" "571.4" "555.7" "581.2" "572.6" "565.1" "555.4" "590.9" "" "" "" "" "" "" "" "" "" "" "516.0" "478.1" "524.8" "441.8" "473.7" "555.3" "523.2" "501.7" "555.4" "569.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4119933875415276465" "False" "High" "IsMasterProtein" "P07902" "Galactose-1-phosphate uridylyltransferase OS=Homo sapiens OX=9606 GN=GALT PE=1 SV=3" "0.000" "False" "6.850" "5" "3" "3" "3" "379" "43.3" "6.99" "8.96" "3" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01087, Pf02744" "2592" "ENSG00000213930" "GALT" "B4E097; E7ET32; hsa:2592; P07902; Q14355; Q14356; Q14357; Q14358; Q14359; Q14360; Q14361; Q14363; Q14364; Q14365; Q14369; Q14370; Q14371; Q14372; Q14373; Q14374; Q14375; Q14377; Q14378; Q14380; Q14381; Q14382; Q14383; Q14384; Q14385; Q14386; Q14387; Q14389; Q16766; Q53XK1; Q5VZ81; Q96BY1" "Disorders of galactose metabolism ; Primary ovarian insufficiency" "Defective GALT can cause GALCT; Galactose catabolism" "4" "0" "0.986" "0.990" "1.066" "0.984" "0.996" "0.990" "0.926" "0.901" "0.941" "386.6" "381.1" "382.8" "412.0" "380.4" "385.0" "382.8" "357.9" "348.5" "363.9" "" "" "" "" "" "" "" "" "" "" "362.3" "315.4" "355.3" "318.5" "324.2" "367.8" "349.8" "317.8" "348.5" "350.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2054594351010378030" "False" "High" "IsMasterProtein" "Q9H977" "WD repeat-containing protein 54 OS=Homo sapiens OX=9606 GN=WDR54 PE=1 SV=1" "0.000" "False" "6.845" "6" "2" "3" "2" "334" "35.9" "6.20" "3.49" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf21031" "84058" "ENSG00000005448" "WDR54" "B9A049; D6W5I3; hsa:84058; Q53H85; Q86V45; Q9H977" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5463770494626313283" "False" "High" "IsMasterProtein" "Q9C035" "Tripartite motif-containing protein 5 OS=Homo sapiens OX=9606 GN=TRIM5 PE=1 SV=1" "0.000" "False" "6.844" "6" "3" "3" "3" "493" "56.3" "6.05" "10.12" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13445" "85363" "ENSG00000132256" "TRIM5" "A6NGQ1; A8WFA8; D3DQS8; D3DQS9; G3GJY1; hsa:85363; Q2MLV4; Q2MLV8; Q2MLV9; Q2MLW1; Q2MLW3; Q2MLW4; Q2MLW6; Q2MLW7; Q2MLX1; Q2MLX2; Q2MLX3; Q2MLX5; Q2MLY3; Q2MLY4; Q2V6Q6; Q6GX26; Q8WU46; Q96SR5; Q9C031; Q9C032; Q9C033; Q9C034; Q9C035" "Mesodermal commitment pathway" "Interferon gamma signaling" "2" "0" "1.006" "0.966" "0.894" "1.018" "0.984" "0.928" "0.917" "0.948" "1.029" "603.4" "606.7" "583.0" "539.6" "614.3" "593.9" "559.6" "553.4" "572.2" "621.1" "" "" "" "" "" "" "" "" "" "" "565.4" "502.0" "541.3" "417.1" "523.6" "567.4" "511.4" "491.4" "572.2" "598.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7384087443166083849" "False" "High" "IsMasterProtein" "O14562" "Ubiquitin domain-containing protein UBFD1 OS=Homo sapiens OX=9606 GN=UBFD1 PE=1 SV=2" "0.000" "False" "6.836" "7" "2" "2" "2" "309" "33.4" "5.77" "6.12" "2" "" "" "" "Pf00240" "56061" "ENSG00000103353" "UBFD1" "A8MW58; D3DWF2; hsa:56061; O14562" "" "" "0" "0" "1.096" "1.001" "1.098" "1.039" "1.042" "1.035" "1.081" "0.972" "1.001" "279.9" "306.8" "280.1" "307.5" "290.7" "291.7" "289.8" "302.5" "272.1" "280.2" "" "" "" "" "" "" "" "" "" "" "262.3" "253.8" "260.1" "237.7" "247.8" "278.7" "264.8" "268.6" "272.1" "269.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8696690186535498755" "False" "High" "IsMasterProtein" "Q9NPJ3" "Acyl-coenzyme A thioesterase 13 OS=Homo sapiens OX=9606 GN=ACOT13 PE=1 SV=1" "0.000" "False" "6.835" "16" "2" "2" "2" "140" "15.0" "9.14" "6.28" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion" "other molecular function" "Pf03061" "55856" "ENSG00000112304" "ACOT13" "F5H2L4; hsa:55856; O95549; Q9NPJ3" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2431037713967118528" "False" "High" "IsMasterProtein" "Q9NW13" "RNA-binding protein 28 OS=Homo sapiens OX=9606 GN=RBM28 PE=1 SV=3" "0.000" "False" "6.828" "3" "2" "2" "2" "759" "85.7" "9.22" "6.61" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00076" "55131" "ENSG00000106344" "RBM28" "A4D100; B4DU52; E9PDD9; hsa:55131; Q53H65; Q96CV3; Q9NW13" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.069" "1.016" "1.366" "1.130" "1.190" "1.613" "1.704" "1.644" "1.224" "180.7" "193.1" "183.5" "246.7" "204.1" "215.1" "291.4" "307.8" "297.0" "221.1" "" "" "" "" "" "" "" "" "" "" "169.3" "159.8" "170.3" "190.7" "174.0" "205.5" "266.3" "273.3" "297.0" "212.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7711116662832737595" "False" "High" "IsMasterProtein" "Q53EZ4" "Centrosomal protein of 55 kDa OS=Homo sapiens OX=9606 GN=CEP55 PE=1 SV=3" "0.000" "False" "6.825" "5" "3" "3" "3" "464" "54.1" "7.01" "9.86" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf12180" "55165" "ENSG00000138180" "CEP55" "B2RDG8; D3DR37; hsa:55165; Q32WF5; Q3MV20; Q53EZ4; Q5VY28; Q6N034; Q96H32; Q9NVS7" "" "" "0" "0" "1.093" "0.966" "0.966" "1.102" "1.093" "0.965" "0.956" "0.936" "1.050" "506.9" "553.8" "489.7" "489.6" "558.4" "554.1" "488.9" "484.5" "474.5" "532.4" "" "" "" "" "" "" "" "" "" "" "474.9" "458.2" "454.6" "378.5" "475.9" "529.4" "446.8" "430.2" "474.5" "512.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4010780836197462310" "False" "High" "IsMasterProtein" "Q15427" "Splicing factor 3B subunit 4 OS=Homo sapiens OX=9606 GN=SF3B4 PE=1 SV=1" "0.000" "False" "6.805" "5" "2" "4" "2" "424" "44.4" "8.56" "11.82" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "10262" "ENSG00000143368" "SF3B4" "hsa:10262; Q15427; Q5SZ63" "mRNA processing; 10q22q23 copy number variation" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "4" "0" "0.967" "0.992" "0.883" "0.992" "1.064" "0.919" "1.063" "1.123" "1.081" "156.8" "151.6" "155.5" "138.4" "155.5" "166.9" "144.1" "166.7" "176.2" "169.5" "" "" "" "" "" "" "" "" "" "" "147.0" "125.5" "144.4" "107.0" "132.6" "159.4" "131.7" "148.0" "176.2" "163.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3490991347050641114" "False" "High" "IsMasterProtein" "Q9H9A7" "RecQ-mediated genome instability protein 1 OS=Homo sapiens OX=9606 GN=RMI1 PE=1 SV=3" "0.000" "False" "6.805" "4" "3" "3" "3" "625" "70.1" "4.96" "8.85" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08585, Pf16099, Pf21000" "80010" "ENSG00000178966" "RMI1" "hsa:80010; Q05BX1; Q05CW3; Q5SQG8; Q5SQG9; Q6P1Q4; Q6PI89; Q7Z6L6; Q9H9A7" "" "Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "14" "0" "0.986" "0.980" "1.009" "1.000" "0.997" "0.993" "1.052" "1.002" "1.030" "802.4" "791.5" "786.5" "809.7" "802.7" "800.2" "796.6" "843.8" "803.6" "826.2" "" "" "" "" "" "" "" "" "" "" "751.8" "655.0" "730.1" "625.9" "684.2" "764.5" "727.8" "749.3" "803.6" "795.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1542485656427922063" "False" "High" "IsMasterProtein" "Q6P1K2" "Polyamine-modulated factor 1 OS=Homo sapiens OX=9606 GN=PMF1 PE=1 SV=2" "0.000" "False" "6.801" "11" "2" "3" "2" "205" "23.3" "5.49" "9.05" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03980" "100527963; 11243" "ENSG00000160783" "PMF1" "A8K0C5; hsa:100527963; hsa:11243; Q5TCJ8; Q5TCJ9; Q5TCK0; Q5TCK1; Q5TCK3; Q69YZ9; Q6P1K2; Q6PHR4; Q6ZVE6; Q86VJ6; Q8N4T6; Q9UBQ3" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.930" "0.874" "1.108" "0.964" "0.988" "1.003" "0.852" "0.975" "0.921" "90.8" "84.5" "79.3" "100.6" "87.6" "89.8" "91.1" "77.4" "88.6" "83.7" "" "" "" "" "" "" "" "" "" "" "85.1" "69.9" "73.7" "77.8" "74.6" "85.8" "83.2" "68.7" "88.6" "80.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8894400129343683729" "False" "High" "IsMasterProtein" "Q9BUH6" "Protein PAXX OS=Homo sapiens OX=9606 GN=PAXX PE=1 SV=2" "0.000" "False" "6.797" "10" "2" "2" "2" "204" "21.6" "5.48" "7.98" "2" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf15384" "286257" "ENSG00000148362" "PAXX" "hsa:286257; Q8IY19; Q9BUH6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2969987479368307007" "False" "High" "IsMasterProtein" "O14657" "Torsin-1B OS=Homo sapiens OX=9606 GN=TOR1B PE=1 SV=2" "0.000" "False" "6.796" "6" "2" "2" "2" "336" "38.0" "8.54" "7.22" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;ER/Golgi;nucleus" "cytoskeletal activity;other molecular function" "Pf06309, Pf21376" "27348" "ENSG00000136816" "TOR1B" "hsa:27348; O14657" "" "Cargo recognition for clathrin-mediated endocytosis" "1" "0" "1.020" "0.968" "1.083" "0.994" "1.013" "0.978" "0.962" "0.978" "1.006" "219.7" "224.0" "212.7" "237.8" "218.4" "222.4" "214.8" "211.3" "214.8" "220.9" "" "" "" "" "" "" "" "" "" "" "205.8" "185.3" "197.5" "183.9" "186.2" "212.5" "196.2" "187.6" "214.8" "212.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3369137616140023088" "False" "High" "IsMasterProtein" "Q9NZJ9" "Diphosphoinositol polyphosphate phosphohydrolase 2 OS=Homo sapiens OX=9606 GN=NUDT4 PE=1 SV=2" "0.000" "False" "6.794" "11" "2" "4" "2" "180" "20.3" "6.35" "12.58" "2" "other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "11163" "ENSG00000173598" "NUDT4" "B7Z916; hsa:11163; Q4AEJ6; Q53EZ2; Q68DD7; Q9NPC5; Q9NS30; Q9NZJ9; Q9NZK0; Q9NZK1" "" "Synthesis of pyrophosphates in the cytosol" "1" "0" "0.986" "0.926" "0.866" "0.964" "1.085" "0.875" "1.002" "0.967" "1.089" "368.8" "363.7" "341.6" "319.4" "355.5" "400.0" "322.6" "369.4" "356.5" "401.5" "" "" "" "" "" "" "" "" "" "" "345.6" "301.0" "317.1" "246.9" "303.0" "382.1" "294.8" "328.0" "356.5" "386.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1728061732538429863" "False" "High" "IsMasterProtein" "Q9UQC2" "GRB2-associated-binding protein 2 OS=Homo sapiens OX=9606 GN=GAB2 PE=1 SV=1" "0.000" "False" "6.791" "3" "2" "2" "2" "676" "74.4" "8.31" "6.59" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00169" "9846" "ENSG00000033327" "GAB2" "A2RRM2; A6NEW9; A7MD36; hsa:9846; O60317; Q9UQC2" "RANKL/RANK signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Imatinib and chronic myeloid leukemia; BDNF-TrkB signaling; IL-4 signaling pathway; Ras signaling; EGF/EGFR signaling pathway; IL-2 signaling pathway; GDNF signaling; Interferon type I signaling pathways; T-cell receptor signaling pathway" "Role of LAT2/NTAL/LAB on calcium mobilization; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Interleukin receptor SHC signaling; PI3K Cascade; Signaling by SCF-KIT; Signaling by CSF3 (G-CSF); Signaling by cytosolic FGFR1 fusion mutants; Signaling by CSF1 (M-CSF) in myeloid cells; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling; STAT5 Activation" "32" "0" "1.104" "1.060" "1.054" "1.063" "1.072" "0.972" "1.017" "1.056" "1.099" "218.0" "240.7" "231.1" "229.7" "231.6" "233.6" "211.8" "221.8" "230.1" "239.6" "" "" "" "" "" "" "" "" "" "" "204.2" "199.2" "214.5" "177.6" "197.4" "223.2" "193.5" "196.9" "230.1" "230.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2934429115890705699" "False" "High" "IsMasterProtein" "P49821" "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV1 PE=1 SV=4" "0.000" "False" "6.790" "5" "2" "2" "2" "464" "50.8" "8.21" "5.96" "2" "other metabolic processes;transport" "other membranes;cytosol;mitochondrion" "transporter activity;other molecular function" "Pf01512, Pf10589" "4723" "ENSG00000167792" "NDUFV1" "hsa:4723; O60924; O60940; P49821; Q16104; Q6IBR3; Q96BF8; Q96HS7" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; HDAC6 interactions in the central nervous system; Oxidative phosphorylation" "Mitochondrial protein degradation; Complex I biogenesis" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8841381739766448706" "False" "High" "IsMasterProtein" "Q2M296" "Methenyltetrahydrofolate synthase domain-containing protein OS=Homo sapiens OX=9606 GN=MTHFSD PE=1 SV=2" "0.000" "False" "6.784" "6" "3" "3" "3" "383" "42.1" "8.73" "7.87" "3" "" "other cell component" "" "Pf00076, Pf01812" "64779" "ENSG00000103248" "MTHFSD" "A8MQ77; B7ZLC0; B7ZLC2; D3DUM9; E9PAM1; hsa:64779; Q2M296; Q9H878; Q9H954" "" "" "0" "0" "1.024" "1.022" "1.096" "1.047" "0.963" "1.132" "0.862" "0.981" "0.973" "114.4" "117.2" "116.9" "125.4" "119.8" "110.2" "129.5" "98.7" "112.2" "111.3" "" "" "" "" "" "" "" "" "" "" "107.2" "96.9" "108.5" "96.9" "102.1" "105.3" "118.4" "87.6" "112.2" "107.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1386453636298102119" "False" "High" "IsMasterProtein" "Q8NDH3" "Probable aminopeptidase NPEPL1 OS=Homo sapiens OX=9606 GN=NPEPL1 PE=1 SV=3" "0.000" "False" "6.767" "4" "2" "2" "2" "523" "55.8" "6.87" "6.31" "2" "protein metabolism" "other cell component" "other molecular function" "Pf00883, Pf18295" "79716" "ENSG00000215440" "NPEPL1" "A6NGZ0; B4DMW7; B7ZBN0; E9PN47; G5EA34; hsa:79716; Q53G37; Q5W083; Q8NDH3; Q8TF28; Q8WUI2; Q9H1T6; Q9HAI5" "" "" "0" "0" "1.057" "0.993" "1.125" "1.044" "1.077" "1.059" "1.007" "0.997" "1.054" "378.4" "400.0" "375.7" "425.5" "395.0" "407.6" "400.8" "380.9" "377.1" "398.9" "" "" "" "" "" "" "" "" "" "" "354.5" "331.0" "348.8" "328.9" "336.7" "389.4" "366.2" "338.2" "377.1" "384.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2174498408520760419" "False" "High" "IsMasterProtein" "Q02241" "Kinesin-like protein KIF23 OS=Homo sapiens OX=9606 GN=KIF23 PE=1 SV=3" "0.000" "False" "6.757" "3" "3" "3" "3" "960" "110.0" "8.51" "5.55" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf16540" "9493" "ENSG00000137807" "KIF23" "B4E1K0; hsa:9493; Q02241; Q8WVP0" "Pleural mesothelioma" "MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Mitotic Telophase/Cytokinesis" "5" "0" "1.432" "0.990" "1.623" "1.109" "1.162" "1.428" "0.918" "1.054" "1.043" "38.9" "55.7" "38.5" "63.1" "43.1" "45.2" "55.6" "35.7" "41.0" "40.6" "" "" "" "" "" "" "" "" "" "" "36.4" "46.1" "35.8" "48.8" "36.8" "43.2" "50.8" "31.7" "41.0" "39.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3071806788293272628" "False" "High" "IsMasterProtein" "Q5EG05" "Caspase recruitment domain-containing protein 16 OS=Homo sapiens OX=9606 GN=CARD16 PE=1 SV=1" "0.000" "False" "6.755" "14" "3" "4" "1" "197" "22.6" "8.44" "7.73" "3" "protein metabolism;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00619" "114769" "ENSG00000204397" "CARD16" "hsa:114769; Q5EG05; Q96RJ9" "" "" "0" "0" "1.059" "1.049" "1.064" "1.071" "1.036" "1.040" "1.172" "1.067" "1.203" "100.4" "106.3" "105.3" "106.7" "107.5" "104.0" "104.3" "117.6" "107.1" "120.7" "" "" "" "" "" "" "" "" "" "" "94.0" "88.0" "97.8" "82.5" "91.6" "99.4" "95.3" "104.4" "107.1" "116.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4653311583040189549" "False" "High" "IsMasterProtein" "Q9H2P9" "Diphthine methyl ester synthase OS=Homo sapiens OX=9606 GN=DPH5 PE=1 SV=2" "0.000" "False" "6.755" "6" "2" "2" "2" "285" "31.6" "5.31" "7.66" "2" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00590" "51611" "ENSG00000117543" "DPH5" "A8JZY6; D3DT62; hsa:51611; Q9H2P9; Q9P017; Q9P0I4; Q9Y319" "" "Synthesis of diphthamide-EEF2" "1" "0" "0.904" "0.926" "0.906" "0.935" "0.976" "0.877" "0.902" "0.928" "0.925" "670.2" "605.9" "620.7" "607.4" "626.9" "654.0" "587.7" "604.3" "621.8" "620.0" "" "" "" "" "" "" "" "" "" "" "627.9" "501.4" "576.3" "469.6" "534.4" "624.8" "537.0" "536.5" "621.8" "597.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7638543548033193713" "False" "High" "IsMasterProtein" "Q00765" "Receptor expression-enhancing protein 5 OS=Homo sapiens OX=9606 GN=REEP5 PE=1 SV=3" "0.000" "False" "6.750" "10" "2" "2" "2" "189" "21.5" "8.10" "6.55" "2" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf03134" "7905" "ENSG00000129625" "REEP5" "B7Z681; D3DT04; hsa:7905; Q00765; Q04198; Q5QGT0; Q9BWH9" "" "" "0" "0" "1.003" "1.037" "0.861" "0.926" "0.997" "0.847" "0.834" "0.804" "0.908" "629.7" "631.3" "652.9" "542.1" "583.2" "627.9" "533.3" "525.3" "506.5" "571.5" "" "" "" "" "" "" "" "" "" "" "590.0" "522.4" "606.2" "419.1" "497.1" "599.9" "487.3" "466.4" "506.5" "550.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5517999105151406307" "False" "High" "IsMasterProtein" "Q9NWT1" "p21-activated protein kinase-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAK1IP1 PE=1 SV=2" "0.000" "False" "6.749" "4" "2" "2" "2" "392" "43.9" "8.91" "7.17" "2" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf00400" "55003" "ENSG00000111845; ENSG00000285226" "PAK1IP1" "hsa:55003; Q5T4J2; Q96QJ8; Q96T87; Q9NWT1" "" "" "0" "0" "0.935" "0.900" "0.942" "1.132" "1.009" "0.993" "1.118" "1.103" "0.970" "240.8" "225.2" "216.6" "226.9" "272.6" "242.9" "239.0" "269.2" "265.6" "233.6" "" "" "" "" "" "" "" "" "" "" "225.6" "186.3" "201.1" "175.4" "232.4" "232.1" "218.4" "239.0" "265.6" "224.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3186791909088934819" "False" "High" "IsMasterProtein" "Q96JB2" "Conserved oligomeric Golgi complex subunit 3 OS=Homo sapiens OX=9606 GN=COG3 PE=1 SV=3" "0.000" "False" "6.746" "4" "3" "3" "3" "828" "94.0" "5.57" "9.23" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "" "Pf04136, Pf20671" "83548" "ENSG00000136152" "COG3" "B2RAW5; hsa:83548; Q5VT70; Q8IXX4; Q96JB2; Q9BZ92" "" "Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network; COPI-mediated anterograde transport" "3" "0" "0.830" "1.034" "0.905" "0.941" "1.087" "0.967" "0.989" "0.992" "1.027" "113.6" "94.3" "117.5" "102.8" "106.9" "123.5" "109.9" "112.4" "112.7" "116.6" "" "" "" "" "" "" "" "" "" "" "106.4" "78.0" "109.1" "79.5" "91.1" "118.0" "100.4" "99.8" "112.7" "112.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4115257495252240726" "False" "High" "IsMasterProtein" "P82909" "Alpha-ketoglutarate dehydrogenase component 4 OS=Homo sapiens OX=9606 GN=KGD4 PE=1 SV=2" "0.000" "False" "6.745" "29" "2" "2" "2" "103" "11.5" "9.99" "7.13" "2" "other metabolic processes" "other membranes;mitochondrion" "" "" "92259" "ENSG00000134056; ENSG00000278461" "KGD4" "hsa:92259; P82909; Q9H2H4" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.074" "1.072" "1.188" "1.178" "1.017" "1.060" "0.993" "0.909" "0.942" "189.8" "203.9" "203.6" "225.5" "223.7" "193.0" "201.3" "188.5" "172.6" "178.9" "" "" "" "" "" "" "" "" "" "" "177.9" "168.7" "189.0" "174.3" "190.7" "184.4" "183.9" "167.4" "172.6" "172.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4248741172720899665" "False" "High" "IsMasterProtein" "P62304" "Small nuclear ribonucleoprotein E OS=Homo sapiens OX=9606 GN=SNRPE PE=1 SV=1" "0.000" "False" "6.742" "25" "2" "6" "2" "92" "10.8" "9.44" "16.09" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "6635" "ENSG00000182004" "SNRPE" "B2R5B9; hsa:6635; P08578; P62304; Q15498; Q5BKT2" "mRNA processing" "snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "1.148" "1.148" "1.223" "1.146" "1.030" "1.209" "1.148" "1.200" "1.023" "367.4" "421.8" "421.7" "449.3" "421.2" "378.6" "444.2" "421.8" "441.0" "376.0" "" "" "" "" "" "" "" "" "" "" "344.3" "349.0" "391.5" "347.3" "359.0" "361.7" "405.8" "374.5" "441.0" "362.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "462571488104407495" "False" "High" "IsMasterProtein" "Q86T24" "Transcriptional regulator Kaiso OS=Homo sapiens OX=9606 GN=ZBTB33 PE=1 SV=2" "0.000" "False" "6.733" "4" "3" "4" "3" "672" "74.4" "5.12" "11.45" "3" "cell-cell signaling;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651" "10009" "ENSG00000177485" "ZBTB33" "B2R5U6; hsa:10009; O00319; Q7Z361; Q86T24; Q8IVP6; Q8N3P0" "Wnt signaling pathway and pluripotency" "" "1" "0" "1.020" "0.981" "0.979" "0.992" "1.047" "0.912" "0.897" "0.995" "0.987" "568.3" "579.9" "557.3" "556.6" "563.5" "595.1" "518.2" "509.9" "565.5" "560.7" "" "" "" "" "" "" "" "" "" "" "532.5" "479.9" "517.4" "430.2" "480.4" "568.5" "473.5" "452.8" "565.5" "539.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4052352701498406510" "False" "High" "IsMasterProtein" "Q9Y6J9" "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L OS=Homo sapiens OX=9606 GN=TAF6L PE=1 SV=1" "0.000" "False" "6.733" "4" "3" "3" "3" "622" "67.8" "8.97" "8.88" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02969, Pf07571" "10629" "ENSG00000162227" "TAF6L" "B2RAT0; hsa:10629; Q96HA6; Q9Y6J9" "" "HATs acetylate histones" "1" "0" "0.941" "0.891" "0.936" "0.899" "0.921" "1.077" "0.902" "0.889" "0.970" "224.0" "210.8" "199.6" "209.6" "201.4" "206.3" "241.2" "202.1" "199.0" "217.3" "" "" "" "" "" "" "" "" "" "" "209.8" "174.4" "185.3" "162.0" "171.6" "197.1" "220.4" "179.4" "199.0" "209.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3125031583536319160" "False" "High" "IsMasterProtein" "P05204" "Non-histone chromosomal protein HMG-17 OS=Homo sapiens OX=9606 GN=HMGN2 PE=1 SV=3" "0.000" "False" "6.732" "22" "2" "3" "2" "90" "9.4" "9.99" "9.54" "2" "cell organization and biogenesis;stress response;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "3151" "ENSG00000198830" "HMGN2" "hsa:3151; P05204; Q0VGD5; Q6FGI5; Q96C64" "" "" "0" "0" "1.264" "1.255" "1.217" "0.939" "0.857" "0.766" "1.035" "1.030" "0.950" "713.0" "901.4" "894.9" "868.0" "669.2" "611.3" "546.3" "737.7" "734.3" "677.5" "" "" "" "" "" "" "" "" "" "" "668.1" "745.9" "830.8" "671.0" "570.4" "584.0" "499.2" "655.0" "734.3" "652.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "602378726444352058" "False" "High" "IsMasterProtein" "O75828" "Carbonyl reductase [NADPH] 3 OS=Homo sapiens OX=9606 GN=CBR3 PE=1 SV=3" "0.000" "False" "6.728" "9" "2" "3" "2" "277" "30.8" "6.18" "7.07" "2" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00106" "874" "ENSG00000159231" "CBR3" "O75828; Q6FHP2" "Nuclear receptors meta-pathway; NRF2 pathway" "Phase I - Functionalization of compounds" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-273580326344755001" "False" "High" "IsMasterProtein" "P26885" "Peptidyl-prolyl cis-trans isomerase FKBP2 OS=Homo sapiens OX=9606 GN=FKBP2 PE=1 SV=2" "0.000" "False" "6.728" "18" "2" "3" "2" "142" "15.6" "9.13" "10.70" "2" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00254" "2286" "ENSG00000173486" "FKBP2" "hsa:2286; P26885; Q5BJH9; Q9BTS7" "Complement system" "" "1" "0" "1.204" "1.047" "1.344" "1.336" "1.047" "1.404" "1.232" "1.050" "1.147" "27.9" "33.6" "29.2" "37.5" "37.3" "29.2" "39.2" "34.4" "29.3" "32.0" "" "" "" "" "" "" "" "" "" "" "26.1" "27.8" "27.1" "29.0" "31.8" "27.9" "35.8" "30.5" "29.3" "30.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7711060710327679778" "False" "High" "IsMasterProtein" "O75886" "Signal transducing adapter molecule 2 OS=Homo sapiens OX=9606 GN=STAM2 PE=1 SV=1" "0.000" "False" "6.715" "5" "2" "3" "2" "525" "58.1" "5.07" "8.17" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00790, Pf02809" "10254" "ENSG00000115145" "STAM2" "A8K8A0; D3DPA1; hsa:10254; O75886; Q7LDQ0; Q9UF58" "EGF/EGFR signaling pathway" "Ub-specific processing proteases; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "9" "0" "1.187" "0.979" "1.437" "1.184" "0.932" "1.083" "1.016" "0.989" "1.042" "64.4" "76.4" "63.1" "92.6" "76.3" "60.0" "69.7" "65.4" "63.7" "67.1" "" "" "" "" "" "" "" "" "" "" "60.4" "63.3" "58.5" "71.6" "65.0" "57.3" "63.7" "58.1" "63.7" "64.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6883874888390724890" "False" "High" "IsMasterProtein" "Q5VTL8" "Pre-mRNA-splicing factor 38B OS=Homo sapiens OX=9606 GN=PRPF38B PE=1 SV=1" "0.000" "False" "6.715" "4" "3" "4" "3" "546" "64.4" "10.54" "10.98" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf03371" "55119" "ENSG00000134186" "PRPF38B" "hsa:55119; Q05DD6; Q32Q58; Q5VTL8; Q5VTL9; Q6PK39; Q7Z6E2; Q86WF3; Q8IWG9; Q9NW40" "" "" "0" "0" "1.049" "1.141" "1.128" "1.033" "1.019" "1.201" "1.281" "1.203" "1.145" "339.8" "356.5" "387.6" "383.1" "350.9" "346.1" "408.1" "435.4" "408.6" "389.0" "" "" "" "" "" "" "" "" "" "" "318.4" "295.0" "359.9" "296.1" "299.1" "330.7" "372.9" "386.6" "408.6" "374.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6342285970436861386" "False" "High" "IsMasterProtein" "Q9UPM8" "AP-4 complex subunit epsilon-1 OS=Homo sapiens OX=9606 GN=AP4E1 PE=1 SV=2" "0.000" "False" "6.711" "2" "2" "2" "2" "1137" "127.2" "5.99" "6.13" "2" "transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf01602, Pf14807" "23431" "ENSG00000081014" "AP4E1" "A0AVD6; A1L4A9; A6NNX7; H0YKX4; hsa:23431; Q68D31; Q9UPM8; Q9Y588" "" "Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis" "2" "0" "1.020" "1.015" "1.378" "1.116" "1.038" "1.051" "1.102" "0.886" "1.046" "79.8" "81.4" "81.1" "110.0" "89.1" "82.8" "84.0" "88.0" "70.7" "83.5" "" "" "" "" "" "" "" "" "" "" "74.8" "67.4" "75.3" "85.1" "75.9" "79.1" "76.7" "78.1" "70.7" "80.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8296927392794764826" "False" "High" "IsMasterProtein" "Q9BZL4" "Protein phosphatase 1 regulatory subunit 12C OS=Homo sapiens OX=9606 GN=PPP1R12C PE=1 SV=1" "0.000" "False" "6.706" "3" "2" "2" "2" "782" "84.8" "5.57" "6.87" "2" "signal transduction" "cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf12796, Pf15898" "54776" "ENSG00000125503" "PPP1R12C" "B4DME2; hsa:54776; Q59FK8; Q6ZPD1; Q7L8F7; Q96HW1; Q9BZL4; Q9H5H5; Q9NT00" "Focal adhesion" "" "1" "0" "1.048" "1.053" "1.085" "1.058" "1.066" "1.007" "1.000" "0.994" "1.067" "69.3" "72.6" "73.0" "75.2" "73.3" "73.9" "69.8" "69.3" "68.9" "74.0" "" "" "" "" "" "" "" "" "" "" "64.9" "60.1" "67.7" "58.1" "62.5" "70.6" "63.8" "61.5" "68.9" "71.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-902532758451743562" "False" "High" "IsMasterProtein" "Q96B26" "Exosome complex component RRP43 OS=Homo sapiens OX=9606 GN=EXOSC8 PE=1 SV=1" "0.000" "False" "6.700" "9" "2" "3" "2" "276" "30.0" "5.30" "10.31" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "11340" "ENSG00000120699" "EXOSC8" "hsa:11340; O43480; Q5TBA5; Q96B26" "" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "1.040" "1.065" "1.004" "1.048" "1.115" "0.957" "1.071" "1.117" "1.038" "252.2" "262.1" "268.6" "253.2" "264.2" "281.2" "241.3" "270.2" "281.7" "261.7" "" "" "" "" "" "" "" "" "" "" "236.3" "216.9" "249.4" "195.7" "225.2" "268.7" "220.5" "239.9" "281.7" "252.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6553541234872075133" "False" "High" "IsMasterProtein" "Q8N488" "RING1 and YY1-binding protein OS=Homo sapiens OX=9606 GN=RYBP PE=1 SV=2" "0.000" "False" "6.699" "12" "2" "2" "2" "228" "24.8" "9.63" "7.02" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00641, Pf17219" "23429" "ENSG00000163602; ENSG00000281766" "RYBP" "hsa:23429; Q8N488; Q9P2W5; Q9UMW4" "" "Transcriptional Regulation by E2F6; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "2" "0" "0.914" "0.946" "1.088" "0.991" "1.064" "1.080" "0.939" "1.019" "1.059" "139.6" "127.6" "132.1" "152.0" "138.3" "148.5" "150.8" "131.1" "142.3" "147.9" "" "" "" "" "" "" "" "" "" "" "130.8" "105.6" "122.7" "117.5" "117.9" "141.9" "137.8" "116.4" "142.3" "142.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2769790673461720299" "False" "High" "IsMasterProtein" "Q96DF8" "Splicing factor ESS-2 homolog OS=Homo sapiens OX=9606 GN=ESS2 PE=1 SV=1" "0.000" "False" "6.697" "7" "3" "3" "3" "476" "52.5" "7.56" "8.77" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "" "Pf09751" "8220" "ENSG00000100056" "ESS2" "hsa:8220; Q49AH7; Q96DF8; Q9BTZ4" "22q11.2 copy number variation syndrome" "" "1" "0" "1.047" "1.085" "1.268" "1.258" "0.983" "1.396" "1.409" "1.136" "0.955" "19.5" "20.4" "21.2" "24.7" "24.5" "19.2" "27.2" "27.5" "22.2" "18.6" "" "" "" "" "" "" "" "" "" "" "18.3" "16.9" "19.6" "19.1" "20.9" "18.3" "24.9" "24.4" "22.2" "17.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3805240560895531655" "False" "High" "IsMasterProtein" "Q15532" "Protein SSXT OS=Homo sapiens OX=9606 GN=SS18 PE=1 SV=3" "0.000" "False" "6.689" "2" "1" "2" "1" "418" "45.9" "6.46" "8.35" "1" "cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05030" "6760" "ENSG00000141380" "SS18" "B0YJ95; hsa:6760; Q15532; Q16404; Q4VAX1; Q9BXC6" "" "" "0" "0" "1.140" "0.992" "0.928" "1.006" "0.977" "0.970" "1.009" "0.910" "0.973" "406.2" "463.1" "403.1" "376.9" "408.7" "396.9" "394.1" "409.8" "369.5" "395.1" "" "" "" "" "" "" "" "" "" "" "380.6" "383.2" "374.2" "291.4" "348.3" "379.2" "360.1" "363.9" "369.5" "380.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6165163621982420395" "False" "High" "IsMasterProtein" "P42694" "Probable helicase with zinc finger domain OS=Homo sapiens OX=9606 GN=HELZ PE=1 SV=2" "0.000" "False" "6.681" "2" "2" "2" "2" "1942" "218.8" "7.42" "6.15" "2" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00642, Pf13086, Pf13087" "9931" "ENSG00000198265" "HELZ" "hsa:9931; I6L9H4; P42694" "" "" "0" "0" "1.147" "1.130" "1.539" "1.172" "1.260" "1.244" "1.078" "1.063" "1.070" "52.4" "60.1" "59.2" "80.7" "61.4" "66.0" "65.2" "56.5" "55.7" "56.0" "" "" "" "" "" "" "" "" "" "" "49.1" "49.7" "54.9" "62.3" "52.4" "63.1" "59.5" "50.1" "55.7" "54.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "105236357953779316" "False" "High" "IsMasterProtein" "Q9H0R4" "Haloacid dehalogenase-like hydrolase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=HDHD2 PE=1 SV=1" "0.000" "False" "6.669" "8" "3" "4" "3" "259" "28.5" "6.24" "11.22" "3" "other metabolic processes" "" "other molecular function" "Pf13242, Pf13344" "84064" "ENSG00000167220" "HDHD2" "A8K7T3; hsa:84064; Q96NV4; Q9H0R4" "" "" "0" "0" "0.966" "0.983" "0.971" "0.974" "0.938" "0.962" "0.953" "0.941" "0.997" "594.0" "573.7" "583.8" "576.5" "578.7" "557.2" "571.1" "566.3" "558.7" "592.3" "" "" "" "" "" "" "" "" "" "" "556.5" "474.8" "542.0" "445.6" "493.3" "532.3" "521.8" "502.8" "558.7" "570.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4572306403840384650" "False" "High" "IsMasterProtein" "O75208" "Ubiquinone biosynthesis protein COQ9, mitochondrial OS=Homo sapiens OX=9606 GN=COQ9 PE=1 SV=1" "0.000" "False" "6.661" "8" "3" "4" "3" "318" "35.5" "5.94" "10.98" "3" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf08511, Pf21392" "57017" "ENSG00000088682" "COQ9" "A8K3L2; hsa:57017; O75208; Q7L5V7; Q7Z5T6; Q8NBL4; Q9NTJ2; Q9P056" "" "Ubiquinol biosynthesis" "1" "0" "1.064" "0.984" "1.058" "1.135" "1.149" "1.014" "1.055" "1.052" "1.103" "341.0" "362.8" "335.6" "360.9" "387.2" "391.7" "345.9" "359.7" "358.8" "376.1" "" "" "" "" "" "" "" "" "" "" "319.5" "300.2" "311.6" "279.0" "330.0" "374.2" "316.1" "319.4" "358.8" "362.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8994364974169992098" "False" "High" "IsMasterProtein" "Q6PIJ6" "F-box only protein 38 OS=Homo sapiens OX=9606 GN=FBXO38 PE=1 SV=3" "0.000" "False" "6.660" "2" "2" "2" "2" "1188" "133.9" "6.33" "5.47" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00646" "81545" "ENSG00000145868" "FBXO38" "hsa:81545; Q6PIJ6; Q6PK72; Q7Z2U0; Q86VN3; Q9BXY6; Q9H837; Q9HC40" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2600353075121762102" "False" "High" "IsMasterProtein" "A4D161" "Protein FAM221A OS=Homo sapiens OX=9606 GN=FAM221A PE=1 SV=1" "0.000" "False" "6.660" "7" "2" "2" "2" "298" "33.1" "6.74" "6.81" "2" "" "" "" "Pf14753" "340277" "ENSG00000188732" "FAM221A" "A4D161; hsa:340277; Q05CG4; Q4G0Q7; Q6P519" "" "" "0" "0" "1.254" "1.091" "1.231" "1.167" "1.138" "1.170" "1.035" "1.076" "1.045" "129.3" "162.2" "141.0" "159.2" "150.9" "147.1" "151.3" "133.7" "139.0" "135.1" "" "" "" "" "" "" "" "" "" "" "121.1" "134.2" "130.9" "123.0" "128.6" "140.6" "138.2" "118.8" "139.0" "130.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1077886033734645757" "False" "High" "IsMasterProtein" "Q5SQI0" "Alpha-tubulin N-acetyltransferase 1 OS=Homo sapiens OX=9606 GN=ATAT1 PE=1 SV=1" "0.000" "False" "6.651" "9" "3" "4" "3" "421" "46.8" "9.95" "10.70" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf05301" "79969" "ENSG00000137343; ENSG00000206488; ENSG00000223752; ENSG00000229061; ENSG00000231257; ENSG00000234549; ENSG00000235658" "ATAT1" "A2AB28; hsa:79969; Q3LIB0; Q5JP39; Q5JP40; Q5JP42; Q5SQI0; Q5SQI1; Q5SU03; Q86X42; Q8NDK9; Q9BRS1; Q9H8X5" "" "Cilium Assembly" "1" "0" "1.009" "0.978" "0.913" "1.210" "1.035" "1.095" "1.088" "1.034" "1.093" "95.1" "96.0" "93.0" "86.8" "115.2" "98.5" "104.2" "103.6" "98.4" "104.0" "" "" "" "" "" "" "" "" "" "" "89.2" "79.5" "86.4" "67.1" "98.2" "94.1" "95.2" "92.0" "98.4" "100.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5013600273074776242" "False" "High" "IsMasterProtein" "Q9NZ09" "Ubiquitin-associated protein 1 OS=Homo sapiens OX=9606 GN=UBAP1 PE=1 SV=1" "0.000" "False" "6.650" "7" "3" "4" "3" "502" "55.0" "5.11" "10.62" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf21267" "51271" "ENSG00000165006" "UBAP1" "B7Z348; B7Z8N9; D3DRL7; F5GXE2; F5H0J8; hsa:51271; Q4V759; Q53FP7; Q5T7B3; Q6FI75; Q8NC52; Q8NCG6; Q8NCH9; Q9NZ09" "" "HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy" "5" "0" "1.074" "1.045" "1.002" "1.091" "1.047" "1.077" "1.045" "0.986" "1.073" "622.7" "668.5" "650.9" "624.2" "679.5" "652.2" "670.4" "650.9" "613.8" "668.0" "" "" "" "" "" "" "" "" "" "" "583.5" "553.1" "604.3" "482.6" "579.2" "623.1" "612.6" "577.9" "613.8" "643.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8164709769345228762" "False" "High" "IsMasterProtein" "Q9H4Z3" "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase OS=Homo sapiens OX=9606 GN=PCIF1 PE=1 SV=1" "0.000" "False" "6.648" "4" "3" "3" "3" "704" "80.6" "7.42" "6.99" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00397, Pf12237" "63935" "ENSG00000100982" "PCIF1" "E1P5P1; hsa:63935; Q54AB9; Q9H4Z3; Q9NT85" "" "" "0" "0" "0.960" "0.954" "0.945" "0.920" "1.057" "0.916" "0.935" "0.998" "1.054" "151.1" "145.1" "144.1" "142.8" "139.0" "159.7" "138.5" "141.2" "150.8" "159.3" "" "" "" "" "" "" "" "" "" "" "141.6" "120.1" "133.8" "110.4" "118.5" "152.5" "126.5" "125.4" "150.8" "153.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6713269859164182683" "False" "High" "IsMasterProtein" "P08567" "Pleckstrin OS=Homo sapiens OX=9606 GN=PLEK PE=1 SV=3" "0.000" "False" "6.633" "8" "2" "2" "2" "350" "40.1" "8.28" "7.87" "2" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00169, Pf00610" "5341" "ENSG00000115956" "PLEK" "B2R9E8; hsa:5341; P08567; Q53SU8; Q6FGM8; Q6FGQ1; Q8WV81" "Serotonin and anxiety-related events; TYROBP causal network in microglia; Serotonin and anxiety" "Platelet degranulation" "4" "0" "0.933" "0.971" "1.052" "1.016" "0.963" "1.049" "0.981" "0.968" "0.973" "277.9" "259.4" "270.0" "292.3" "282.4" "267.8" "291.5" "272.8" "269.0" "270.4" "" "" "" "" "" "" "" "" "" "" "260.4" "214.7" "250.6" "226.0" "240.7" "255.8" "266.3" "242.2" "269.0" "260.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2563545888999241244" "False" "High" "IsMasterProtein" "Q9P2D3" "HEAT repeat-containing protein 5B OS=Homo sapiens OX=9606 GN=HEATR5B PE=1 SV=2" "0.000" "False" "6.630" "1" "3" "3" "3" "2071" "224.2" "7.17" "9.11" "3" "transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf20210" "54497" "ENSG00000008869" "HEATR5B" "B5MDU8; hsa:54497; Q7Z3B2; Q9NVL7; Q9P2D3" "" "" "0" "0" "0.972" "1.013" "1.079" "1.034" "0.985" "1.005" "0.901" "0.944" "1.038" "388.3" "377.6" "393.2" "419.0" "401.5" "382.4" "390.2" "350.0" "366.4" "402.9" "" "" "" "" "" "" "" "" "" "" "363.9" "312.4" "365.1" "323.9" "342.2" "365.3" "356.5" "310.8" "366.4" "388.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1773607396615155691" "False" "High" "IsMasterProtein" "Q16774" "Guanylate kinase OS=Homo sapiens OX=9606 GN=GUK1 PE=1 SV=2" "0.000" "False" "6.610" "8" "2" "5" "2" "197" "21.7" "6.55" "14.54" "2" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00625" "2987" "ENSG00000143774" "GUK1" "B1ANH1; hsa:2987; Q16774" "" "Interconversion of nucleotide di- and triphosphates; Azathioprine ADME" "2" "0" "0.940" "0.985" "0.913" "1.099" "1.054" "0.985" "0.965" "1.028" "1.016" "220.5" "207.2" "217.2" "201.4" "242.3" "232.3" "217.2" "212.8" "226.6" "224.0" "" "" "" "" "" "" "" "" "" "" "206.6" "171.5" "201.7" "155.7" "206.5" "222.0" "198.5" "188.9" "226.6" "215.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6950244637905263726" "False" "High" "IsMasterProtein" "Q9Y3B4" "Splicing factor 3B subunit 6 OS=Homo sapiens OX=9606 GN=SF3B6 PE=1 SV=1" "0.000" "False" "6.593" "23" "3" "4" "3" "125" "14.6" "9.38" "10.93" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "nucleic acid binding activity" "Pf00076" "51639" "ENSG00000115128" "SF3B6" "hsa:51639; Q53TM1; Q9Y3B4" "" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "2" "0" "1.033" "1.045" "0.950" "0.984" "0.974" "1.076" "1.100" "1.073" "1.011" "586.3" "605.6" "612.4" "556.9" "577.0" "571.0" "630.6" "645.1" "629.0" "592.7" "" "" "" "" "" "" "" "" "" "" "549.4" "501.1" "568.6" "430.5" "491.8" "545.5" "576.2" "572.8" "629.0" "570.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4842107794335973179" "False" "High" "IsMasterProtein" "P15336" "Cyclic AMP-dependent transcription factor ATF-2 OS=Homo sapiens OX=9606 GN=ATF2 PE=1 SV=4" "0.000" "False" "6.582" "6" "4" "4" "2" "505" "54.5" "7.88" "9.99" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "1386" "ENSG00000115966" "ATF2" "A1L3Z2; A4D7U4; A4D7U5; A4D7V1; D3DPE9; G8JLM5; hsa:1386; P15336; Q13000; Q3B7B7; Q4ZFU9; Q53RY2; Q8TAR1; Q96JT8" "Energy metabolism; IL-1 signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; ATM signaling pathway; Interleukin-1 (IL-1) structural pathway; Myometrial relaxation and contraction pathways; Photodynamic therapy-induced AP-1 survival signaling; TGF-beta signaling pathway; MAPK signaling pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; DNA IR-double strand breaks and cellular response via ATM; Ethanol effects on histone modifications; p38 MAPK signaling pathway; PI3K-Akt signaling pathway; Thermogenesis; Gastrin signaling pathway; Hepatitis B infection; Thyroid hormones production and peripheral downstream signaling effects; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; 10q11.21q11.23 copy number variation syndrome; T-cell receptor signaling pathway" "NGF-stimulated transcription; Heme signaling; Regulation of PTEN gene transcription; TP53 Regulates Transcription of DNA Repair Genes; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Estrogen-dependent gene expression; HATs acetylate histones; Activation of the AP-1 family of transcription factors; Response of EIF2AK4 (GCN2) to amino acid deficiency" "36" "2" "1.019" "0.988" "0.970" "0.997" "1.009" "0.952" "1.005" "0.962" "1.018" "500.0" "509.3" "494.2" "485.3" "498.7" "504.5" "475.8" "502.4" "481.1" "509.0" "" "" "" "" "" "" "" "" "" "" "468.5" "421.5" "458.8" "375.1" "425.1" "482.0" "434.8" "446.1" "481.1" "490.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2210481861453836415" "False" "High" "IsMasterProtein" "Q9BVM2" "Protein DPCD OS=Homo sapiens OX=9606 GN=DPCD PE=1 SV=2" "0.000" "False" "6.578" "14" "3" "4" "3" "203" "23.2" "9.03" "11.83" "3" "transport;developmental processes;other biological processes" "non-structural extracellular" "" "Pf14913" "25911" "ENSG00000166171" "DPCD" "A8K289; hsa:25911; Q6QNL3; Q8N5R1; Q9BVM2; Q9UFY6" "" "" "0" "0" "0.991" "1.036" "1.014" "1.066" "1.102" "0.970" "1.160" "1.055" "1.056" "465.8" "461.5" "482.4" "472.2" "496.7" "513.4" "452.0" "540.2" "491.3" "492.0" "" "" "" "" "" "" "" "" "" "" "436.5" "381.9" "447.8" "365.0" "423.4" "490.5" "413.0" "479.6" "491.3" "473.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2896751395551910999" "False" "High" "IsMasterProtein" "O95236" "Apolipoprotein L3 OS=Homo sapiens OX=9606 GN=APOL3 PE=1 SV=3" "0.000" "False" "6.577" "6" "3" "3" "3" "402" "44.3" "8.16" "8.94" "3" "protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;other cell component" "transporter activity;other molecular function" "Pf05461" "80833" "ENSG00000128284" "APOL3" "B1AHI4; B1AHI5; hsa:80833; O95236; Q5U5N4; Q9BQ82; Q9BQA3" "" "" "0" "0" "1.081" "0.941" "1.129" "1.041" "0.950" "1.038" "0.841" "0.810" "0.949" "260.5" "281.7" "245.3" "294.1" "271.1" "247.6" "270.4" "219.1" "211.1" "247.2" "" "" "" "" "" "" "" "" "" "" "244.1" "233.1" "227.7" "227.3" "231.1" "236.6" "247.0" "194.6" "211.1" "238.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4899059138870577225" "False" "High" "IsMasterProtein" "Q7Z7F7" "Large ribosomal subunit protein mL55 OS=Homo sapiens OX=9606 GN=MRPL55 PE=1 SV=1" "0.000" "False" "6.575" "17" "2" "4" "2" "128" "15.1" "11.15" "7.58" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;other cell component" "other molecular function" "Pf09776" "128308" "ENSG00000162910" "MRPL55" "hsa:128308; Q5TBY3; Q5TBY6; Q6UWI8; Q7Z7F7" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.034" "0.990" "1.034" "0.985" "1.056" "0.944" "1.051" "0.937" "1.054" "266.4" "275.4" "263.7" "275.3" "262.4" "281.4" "251.4" "279.9" "249.7" "280.8" "" "" "" "" "" "" "" "" "" "" "249.6" "227.9" "244.8" "212.9" "223.7" "268.8" "229.7" "248.5" "249.7" "270.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6865133109964514058" "False" "High" "IsMasterProtein" "Q9NVS2" "Large ribosomal subunit protein mL66 OS=Homo sapiens OX=9606 GN=MRPS18A PE=1 SV=1" "0.000" "False" "6.574" "12" "3" "3" "3" "196" "22.2" "10.33" "8.20" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf01084" "55168" "ENSG00000096080" "MRPS18A" "A6XND3; hsa:55168; Q5QPA4; Q9NVS2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.972" "1.022" "0.905" "1.020" "1.141" "0.965" "1.115" "0.996" "1.022" "449.1" "436.5" "458.9" "406.5" "458.3" "512.4" "433.3" "500.6" "447.4" "458.8" "" "" "" "" "" "" "" "" "" "" "420.8" "361.2" "426.0" "314.2" "390.6" "489.5" "395.9" "444.5" "447.4" "441.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1801369761430289409" "False" "High" "IsMasterProtein" "Q12968" "Nuclear factor of activated T-cells, cytoplasmic 3 OS=Homo sapiens OX=9606 GN=NFATC3 PE=1 SV=1" "0.000" "False" "6.561" "2" "2" "3" "1" "1075" "115.5" "6.37" "5.01" "2" "stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "4775" "ENSG00000072736" "NFATC3" "hsa:4775; O75211; Q12968; Q14516; Q99840; Q99841; Q99842" "Heart development; B cell receptor signaling pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; Wnt signaling; Cancer immunotherapy by PD-1 blockade; Hepatitis B infection" "FCERI mediated Ca+2 mobilization; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8767729618822811067" "False" "High" "IsMasterProtein" "O14933" "Ubiquitin/ISG15-conjugating enzyme E2 L6 OS=Homo sapiens OX=9606 GN=UBE2L6 PE=1 SV=4" "0.000" "False" "6.554" "15" "2" "3" "2" "153" "17.8" "7.88" "10.41" "2" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "9246" "ENSG00000156587" "UBE2L6" "A6NDM6; A8MY53; hsa:9246; O14933; Q8N5D8; Q9UEZ0" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; 7q11.23 copy number variation syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; RSV-host interactions; Amyloid fiber formation; PKR-mediated signaling; ISG15 antiviral mechanism; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3003909500726814877" "False" "High" "IsMasterProtein" "O60443" "Gasdermin-E OS=Homo sapiens OX=9606 GN=GSDME PE=1 SV=2" "0.000" "False" "6.552" "5" "2" "3" "2" "496" "54.5" "5.17" "7.59" "2" "transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "transporter activity;other molecular function" "Pf04598, Pf17708" "1687" "ENSG00000105928" "GSDME" "A4D156; B2RAX9; B3KT05; O14590; O60443; Q08AQ8; Q9UBV3" "" "Regulation of TLR by endogenous ligand; Release of apoptotic factors from the mitochondria; Pyroptosis; Defective pyroptosis" "4" "0" "1.176" "0.960" "1.259" "1.134" "0.938" "0.984" "0.921" "0.868" "1.020" "134.5" "158.3" "129.2" "169.4" "152.6" "126.2" "132.4" "123.9" "116.8" "137.3" "" "" "" "" "" "" "" "" "" "" "126.1" "131.0" "119.9" "130.9" "130.1" "120.5" "121.0" "110.0" "116.8" "132.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "139312885901764532" "False" "High" "IsMasterProtein" "Q53H54" "tRNA wybutosine-synthesizing protein 2 homolog OS=Homo sapiens OX=9606 GN=TRMT12 PE=1 SV=1" "0.000" "False" "6.544" "5" "3" "3" "3" "448" "50.2" "7.97" "8.57" "3" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf02475" "55039" "ENSG00000183665" "TRMT12" "hsa:55039; Q53H54; Q6PKB9; Q96F21; Q9NWK6" "" "Synthesis of wybutosine at G37 of tRNA(Phe)" "1" "0" "0.933" "0.811" "0.896" "0.937" "0.888" "0.873" "0.974" "0.831" "0.861" "86.9" "81.1" "70.4" "77.8" "81.4" "77.2" "75.9" "84.7" "72.2" "74.8" "" "" "" "" "" "" "" "" "" "" "81.4" "67.1" "65.4" "60.2" "69.4" "73.7" "69.3" "75.2" "72.2" "72.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2766829585988969351" "False" "High" "IsMasterProtein" "O75190" "DnaJ homolog subfamily B member 6 OS=Homo sapiens OX=9606 GN=DNAJB6 PE=1 SV=2" "0.000" "False" "6.537" "7" "2" "2" "2" "326" "36.1" "9.16" "6.33" "2" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00226" "10049" "ENSG00000105993" "DNAJB6" "A4D232; A8K7D8; A8KAG0; B4DN73; E9PCZ2; hsa:10049; O75190; O95806; Q53EN8; Q59EF2; Q6FIC8; Q75MA2; Q9UIK6" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "1.005" "0.868" "0.784" "0.970" "0.905" "0.864" "0.873" "0.891" "0.943" "115.5" "116.0" "100.3" "90.5" "112.0" "104.5" "99.7" "100.8" "102.8" "108.9" "" "" "" "" "" "" "" "" "" "" "108.2" "96.0" "93.1" "70.0" "95.4" "99.9" "91.1" "89.5" "102.8" "104.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4412599355076663570" "False" "High" "IsMasterProtein" "Q8WV92" "MIT domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MITD1 PE=1 SV=1" "0.000" "False" "6.528" "10" "2" "2" "2" "249" "29.3" "8.00" "5.86" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04212, Pf16565" "129531" "ENSG00000158411" "MITD1" "hsa:129531; Q69YV0; Q8WV92" "TAR syndrome" "" "1" "0" "1.064" "1.019" "1.142" "1.042" "1.024" "1.084" "1.012" "1.052" "1.070" "171.7" "182.7" "174.9" "196.0" "178.8" "175.8" "186.0" "173.8" "180.5" "183.7" "" "" "" "" "" "" "" "" "" "" "160.9" "151.2" "162.4" "151.5" "152.4" "168.0" "170.0" "154.3" "180.5" "176.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1601323890120227237" "False" "High" "IsMasterProtein" "Q9NQZ6" "Zinc finger C4H2 domain-containing protein OS=Homo sapiens OX=9606 GN=ZC4H2 PE=1 SV=1" "0.000" "False" "6.519" "10" "3" "3" "3" "224" "26.2" "7.14" "5.27" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf10146" "55906" "ENSG00000126970" "ZC4H2" "B2RDC2; B3KVZ5; B4DED0; E7EM74; G3V1L3; hsa:55906; Q53H73; Q5JTF9; Q9H9C3; Q9H9H7; Q9NQZ6; Q9ULQ4" "" "" "0" "0" "1.210" "1.072" "1.344" "1.220" "1.219" "1.134" "1.111" "1.298" "0.985" "43.7" "52.8" "46.8" "58.7" "53.2" "53.2" "49.5" "48.5" "56.7" "43.0" "" "" "" "" "" "" "" "" "" "" "40.9" "43.7" "43.5" "45.4" "45.4" "50.8" "45.2" "43.1" "56.7" "41.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7499774936196670588" "False" "High" "IsMasterProtein" "A0A3B3IU46" "RNA guanine-N7 methyltransferase-activating subunit-like protein OS=Homo sapiens OX=9606 GN=RAMACL PE=3 SV=1" "0.000" "False" "6.498" "20" "3" "4" "3" "118" "14.4" "8.40" "11.97" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf15320" "" "ENSG00000235272" "RAMACL" "A0A3B3IU46" "" "" "0" "0" "1.007" "1.023" "0.884" "1.020" "1.038" "0.924" "1.042" "1.090" "1.041" "583.2" "587.4" "596.3" "515.7" "594.8" "605.2" "538.9" "607.5" "635.7" "607.3" "" "" "" "" "" "" "" "" "" "" "546.4" "486.1" "553.6" "398.6" "507.0" "578.3" "492.4" "539.4" "635.7" "584.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5820747965278093086" "False" "High" "IsMasterProtein" "Q9BPX7" "UPF0415 protein C7orf25 OS=Homo sapiens OX=9606 GN=C7orf25 PE=1 SV=1" "0.000" "False" "6.482" "6" "2" "2" "2" "421" "46.4" "6.42" "6.43" "2" "" "" "" "Pf07000, Pf18474" "79020" "ENSG00000136197" "C7orf25" "A4D1V2; hsa:79020; J3KR36; Q9BPX7; Q9H779" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4477032751293866758" "False" "High" "IsMasterProtein" "Q96MF7" "E3 SUMO-protein ligase NSE2 OS=Homo sapiens OX=9606 GN=NSMCE2 PE=1 SV=2" "0.000" "False" "6.476" "10" "3" "4" "3" "247" "27.9" "7.74" "10.93" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11789" "286053" "ENSG00000156831" "NSMCE2" "hsa:286053; Q8N549; Q96MF7" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5611096213630678464" "False" "High" "IsMasterProtein" "P11279" "Lysosome-associated membrane glycoprotein 1 OS=Homo sapiens OX=9606 GN=LAMP1 PE=1 SV=3" "0.000" "False" "6.474" "4" "2" "3" "2" "417" "44.9" "8.75" "8.61" "2" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01299, Pf21222" "3916" "ENSG00000185896" "LAMP1" "B4DWL3; hsa:3916; P11279; Q8WU33; Q96I40; Q9BRD2; Q9NP13" "" "Neutrophil degranulation" "1" "0" "0.990" "0.941" "1.016" "1.007" "0.932" "0.999" "0.975" "0.837" "0.916" "175.0" "173.3" "164.7" "177.9" "176.3" "163.2" "174.9" "170.6" "146.5" "160.3" "" "" "" "" "" "" "" "" "" "" "164.0" "143.4" "152.9" "137.5" "150.2" "155.9" "159.8" "151.5" "146.5" "154.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8766767178054047588" "False" "High" "IsMasterProtein" "Q9BYC9" "Large ribosomal subunit protein bL20m OS=Homo sapiens OX=9606 GN=MRPL20 PE=1 SV=1" "0.000" "False" "6.472" "15" "3" "3" "3" "149" "17.4" "10.86" "8.22" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00453" "55052" "ENSG00000242485" "MRPL20" "B2RE41; B7Z746; hsa:55052; Q9BYC9" "1p36 copy number variation syndrome" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "0.923" "0.949" "0.956" "0.910" "0.893" "0.901" "0.871" "0.905" "0.879" "193.4" "178.6" "183.5" "184.9" "176.0" "172.6" "174.2" "168.4" "175.0" "170.1" "" "" "" "" "" "" "" "" "" "" "181.2" "147.7" "170.4" "142.9" "150.0" "164.9" "159.2" "149.5" "175.0" "163.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1011365371626777610" "False" "High" "IsMasterProtein" "P56277" "Cx9C motif-containing protein 4 OS=Homo sapiens OX=9606 GN=CMC4 PE=1 SV=1" "0.000" "False" "6.470" "25" "2" "2" "2" "68" "7.7" "8.18" "8.24" "2" "" "mitochondrion" "" "Pf08991" "100272147" "ENSG00000182712" "CMC4" "hsa:100272147; P56277; Q5HYP9" "" "Mitochondrial protein import" "1" "0" "0.969" "0.924" "0.901" "0.932" "0.931" "0.879" "0.964" "0.881" "0.907" "583.2" "565.4" "539.0" "525.5" "543.5" "542.7" "512.6" "562.2" "513.9" "529.1" "" "" "" "" "" "" "" "" "" "" "546.5" "467.9" "500.4" "406.3" "463.3" "518.5" "468.4" "499.2" "513.9" "509.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1245532746290238029" "False" "High" "IsMasterProtein" "P61353" "Large ribosomal subunit protein eL27 OS=Homo sapiens OX=9606 GN=RPL27 PE=1 SV=2" "0.000" "False" "6.460" "13" "2" "2" "2" "136" "15.8" "10.56" "6.36" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00467, Pf01777" "6155" "ENSG00000131469" "RPL27" "hsa:6155; P08526; P61353; Q4G0A9" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.050" "1.016" "0.938" "1.177" "1.060" "1.162" "1.020" "1.009" "1.052" "357.1" "374.8" "362.7" "335.1" "420.2" "378.7" "414.8" "364.4" "360.3" "375.7" "" "" "" "" "" "" "" "" "" "" "334.6" "310.1" "336.7" "259.0" "358.2" "361.8" "379.0" "323.5" "360.3" "361.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5912307548831863099" "False" "High" "IsMasterProtein" "P25398" "Small ribosomal subunit protein eS12 OS=Homo sapiens OX=9606 GN=RPS12 PE=1 SV=3" "0.000" "False" "6.458" "14" "2" "3" "2" "132" "14.5" "7.21" "7.63" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6206" "ENSG00000112306" "RPS12" "hsa:6206; P25398; Q76M58" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.076" "1.066" "1.138" "1.135" "1.150" "1.167" "1.172" "1.075" "0.950" "114.7" "123.4" "122.2" "130.5" "130.2" "131.8" "133.7" "134.4" "123.3" "108.9" "" "" "" "" "" "" "" "" "" "" "107.4" "102.1" "113.4" "100.8" "111.0" "125.9" "122.2" "119.4" "123.3" "104.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7198210632893501960" "False" "High" "IsMasterProtein" "Q07864" "DNA polymerase epsilon catalytic subunit A OS=Homo sapiens OX=9606 GN=POLE PE=1 SV=5" "0.000" "False" "6.444" "1" "2" "2" "2" "2286" "261.4" "6.39" "6.24" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes" "plasma membrane;other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf00136, Pf03104, Pf08490" "5426" "ENSG00000177084" "POLE" "hsa:5426; Q07864; Q13533; Q86VH9" "Retinoblastoma gene in cancer; Pyrimidine metabolism; G1 to S cell cycle control; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Activation of the pre-replicative complex; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; DNA replication initiation; Gap-filling DNA repair synthesis and ligation in GG-NER" "19" "0" "1.063" "1.041" "0.950" "1.112" "0.984" "0.922" "0.942" "1.067" "0.984" "208.2" "221.2" "216.7" "197.9" "231.6" "204.9" "192.0" "196.2" "222.2" "204.8" "" "" "" "" "" "" "" "" "" "" "195.1" "183.1" "201.2" "153.0" "197.4" "195.7" "175.4" "174.2" "222.2" "197.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3487009987400899106" "False" "High" "IsMasterProtein" "P13051" "Uracil-DNA glycosylase OS=Homo sapiens OX=9606 GN=UNG PE=1 SV=2" "0.000" "False" "6.444" "10" "2" "2" "2" "313" "34.6" "9.32" "7.01" "2" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion;nucleus" "translation activity;nucleic acid binding activity;other molecular function" "Pf03167" "7374" "ENSG00000076248" "UNG" "A8K5M6; B2R8Y1; hsa:7374; O00637; O00719; P13051; Q93028" "Base excision repair; DNA repair pathways, full network" "Chromatin modifications during the maternal to zygotic transition (MZT)" "3" "0" "1.251" "1.135" "1.263" "1.219" "1.219" "1.404" "1.274" "1.175" "1.195" "152.6" "191.0" "173.2" "192.8" "186.1" "186.1" "214.3" "194.5" "179.3" "182.4" "" "" "" "" "" "" "" "" "" "" "143.0" "158.1" "160.8" "149.1" "158.6" "177.8" "195.8" "172.7" "179.3" "175.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5531116507177860716" "False" "High" "IsMasterProtein" "Q06609" "DNA repair protein RAD51 homolog 1 OS=Homo sapiens OX=9606 GN=RAD51 PE=1 SV=1" "0.000" "False" "6.441" "11" "3" "3" "3" "339" "36.9" "5.60" "8.90" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423, Pf14520" "5888" "ENSG00000051180" "RAD51" "B0FXP0; B2R8T6; hsa:5888; Q06609; Q6FHX9; Q6ZNA8; Q9BV60" "miRNA regulation of DNA damage response; Homologous recombination; ATM signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Ovarian infertility; Breast cancer pathway; Pancreatic adenocarcinoma pathway; DNA repair pathways, full network; Primary ovarian insufficiency; DNA damage response" "Resolution of D-loop Structures through Holliday Junction Intermediates; Transcriptional Regulation by E2F6; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "23" "0" "1.004" "1.076" "1.010" "1.061" "1.014" "0.935" "0.948" "0.974" "0.976" "403.6" "405.1" "434.5" "407.5" "428.2" "409.1" "377.5" "382.5" "393.2" "393.9" "" "" "" "" "" "" "" "" "" "" "378.2" "335.3" "403.3" "315.0" "365.0" "390.9" "344.9" "339.6" "393.2" "379.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4895248664825856717" "False" "High" "IsMasterProtein" "Q9UGP4" "LIM domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LIMD1 PE=1 SV=1" "0.000" "False" "6.439" "4" "3" "3" "3" "676" "72.1" "6.65" "5.54" "3" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00412" "8994" "ENSG00000144791" "LIMD1" "hsa:8994; Q17RQ1; Q9BQQ9; Q9NQ47; Q9UGP4" "Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Pleural mesothelioma" "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha" "3" "0" "1.002" "0.947" "1.061" "0.997" "0.965" "0.990" "1.054" "0.895" "0.934" "478.6" "479.6" "453.3" "507.9" "477.0" "461.6" "473.8" "504.5" "428.3" "446.8" "" "" "" "" "" "" "" "" "" "" "448.4" "396.8" "420.8" "392.6" "406.6" "441.0" "432.9" "448.0" "428.3" "430.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8918324511185795548" "False" "High" "IsMasterProtein" "Q9BVC4" "Target of rapamycin complex subunit LST8 OS=Homo sapiens OX=9606 GN=MLST8 PE=1 SV=1" "0.000" "False" "6.431" "6" "2" "3" "2" "326" "35.9" "5.86" "8.86" "2" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf00400" "64223" "ENSG00000167965" "MLST8" "B3KMM4; B4DY00; D3DU88; hsa:64223; Q5M800; Q86Y18; Q8WUI5; Q9BVC4; Q9HA66; Q9UJV6" "Target of rapamycin signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Thermogenesis; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Autophagy; p53 transcriptional gene network; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; JAK-STAT signaling in the regulation of beta cells; ADHD and autism (ASD) linked metabolic pathways and SNP; Interferon type I signaling pathways" "Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; CD28 dependent PI3K/Akt signaling; VEGFR2 mediated vascular permeability; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; HSF1-dependent transactivation" "34" "0" "1.036" "1.050" "0.985" "0.938" "0.899" "1.010" "0.791" "0.932" "0.915" "179.3" "185.8" "188.3" "176.6" "168.2" "161.2" "181.1" "141.9" "167.1" "164.0" "" "" "" "" "" "" "" "" "" "" "168.0" "153.8" "174.8" "136.6" "143.4" "154.0" "165.5" "126.0" "167.1" "157.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4240907950946080993" "False" "High" "IsMasterProtein" "Q9BV44" "tRNA (guanine(6)-N2)-methyltransferase THUMP3 OS=Homo sapiens OX=9606 GN=THUMPD3 PE=1 SV=1" "0.000" "False" "6.427" "3" "2" "4" "2" "507" "57.0" "6.37" "13.16" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01170, Pf02926" "25917" "ENSG00000134077" "THUMPD3" "hsa:25917; Q9BV44; Q9H8V6; Q9NVC1; Q9UFS3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5981502460717336485" "False" "High" "IsMasterProtein" "O60244" "Mediator of RNA polymerase II transcription subunit 14 OS=Homo sapiens OX=9606 GN=MED14 PE=1 SV=2" "0.000" "False" "6.420" "1" "2" "2" "2" "1454" "160.5" "8.73" "7.61" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf08638" "9282" "ENSG00000180182" "MED14" "hsa:9282; O60244; Q4KMR7; Q9UNB3" "Vitamin D in inflammatory diseases" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "5" "0" "1.025" "1.006" "1.062" "1.025" "1.048" "1.160" "1.011" "1.007" "1.014" "426.9" "437.5" "429.6" "453.2" "437.5" "447.5" "495.2" "431.7" "429.9" "433.0" "" "" "" "" "" "" "" "" "" "" "400.0" "362.1" "398.8" "350.3" "372.9" "427.5" "452.5" "383.3" "429.9" "416.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7444936349459715889" "False" "High" "IsMasterProtein" "Q32P28" "Prolyl 3-hydroxylase 1 OS=Homo sapiens OX=9606 GN=P3H1 PE=1 SV=2" "0.000" "False" "6.420" "2" "2" "2" "2" "736" "83.3" "5.14" "6.94" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf13640" "64175" "ENSG00000117385" "P3H1" "hsa:64175; Q32P28; Q7KZR4; Q96BR8; Q96SK8; Q96SL5; Q96SN3; Q9H6K3; Q9HC86; Q9HC87" "Type I collagen synthesis in the context of osteogenesis imperfecta" "Collagen biosynthesis and modifying enzymes" "2" "0" "0.947" "0.982" "0.952" "0.965" "0.954" "0.859" "0.971" "0.949" "0.968" "407.1" "385.4" "399.7" "387.4" "392.7" "388.4" "349.8" "395.5" "386.6" "394.1" "" "" "" "" "" "" "" "" "" "" "381.5" "318.9" "371.0" "299.5" "334.7" "371.1" "319.6" "351.2" "386.6" "379.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3054856418516569750" "False" "High" "IsMasterProtein" "Q8IZ07" "Ankyrin repeat domain-containing protein 13A OS=Homo sapiens OX=9606 GN=ANKRD13A PE=1 SV=3" "0.000" "False" "6.417" "6" "2" "2" "2" "590" "67.6" "5.02" "7.87" "2" "other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf11904, Pf12796" "88455" "ENSG00000076513" "ANKRD13A" "hsa:88455; O60736; Q8IZ07" "" "" "0" "0" "1.213" "1.166" "1.214" "1.063" "0.969" "1.087" "1.049" "1.141" "0.967" "19.1" "23.1" "22.2" "23.1" "20.3" "18.5" "20.7" "20.0" "21.7" "18.4" "" "" "" "" "" "" "" "" "" "" "17.9" "19.1" "20.6" "17.9" "17.3" "17.6" "18.9" "17.7" "21.7" "17.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4629432555354117988" "False" "High" "IsMasterProtein" "P78537" "Biogenesis of lysosome-related organelles complex 1 subunit 1 OS=Homo sapiens OX=9606 GN=BLOC1S1 PE=1 SV=2" "0.000" "False" "6.400" "14" "2" "2" "2" "153" "17.3" "9.33" "4.29" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "" "Pf06320" "2647" "ENSG00000135441" "BLOC1S1" "A1L4Q9; hsa:2647; P78537; Q6NZ45" "Alstrom syndrome" "Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis" "3" "0" "0.977" "0.901" "1.098" "0.962" "1.063" "1.007" "0.995" "0.960" "1.062" "327.4" "319.8" "295.1" "359.4" "315.0" "348.0" "329.6" "325.7" "314.2" "347.6" "" "" "" "" "" "" "" "" "" "" "306.8" "264.6" "274.0" "277.9" "268.5" "332.4" "301.2" "289.2" "314.2" "334.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2956941067343712987" "False" "High" "IsMasterProtein" "O75718" "Cartilage-associated protein OS=Homo sapiens OX=9606 GN=CRTAP PE=1 SV=1" "0.000" "False" "6.399" "7" "3" "3" "3" "401" "46.5" "5.73" "4.93" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "" "" "10491" "ENSG00000170275" "CRTAP" "B2RBL6; hsa:10491; O75718" "Type I collagen synthesis in the context of osteogenesis imperfecta" "Collagen biosynthesis and modifying enzymes" "2" "0" "1.235" "1.051" "1.461" "1.234" "1.269" "1.254" "1.283" "1.210" "1.089" "105.1" "129.8" "110.5" "153.6" "129.7" "133.4" "131.8" "134.9" "127.2" "114.5" "" "" "" "" "" "" "" "" "" "" "98.5" "107.4" "102.6" "118.8" "110.6" "127.4" "120.5" "119.8" "127.2" "110.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2965457832063428151" "False" "High" "IsMasterProtein" "A8MW92" "PHD finger protein 20-like protein 1 OS=Homo sapiens OX=9606 GN=PHF20L1 PE=1 SV=2" "0.000" "False" "6.398" "2" "2" "2" "2" "1017" "114.9" "6.83" "4.61" "2" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf16660, Pf18104, Pf20826" "51105" "ENSG00000129292" "PHF20L1" "A8MW92; A8MZC9; hsa:51105; Q86U89; Q86W43; Q96BT0; Q9H702; Q9HBK3; Q9NYR3; Q9Y381" "" "Formation of WDR5-containing histone-modifying complexes" "1" "0" "0.933" "0.959" "0.874" "1.021" "0.972" "0.804" "0.864" "0.841" "0.985" "219.9" "205.1" "210.9" "192.1" "224.5" "213.6" "176.9" "189.9" "185.0" "216.7" "" "" "" "" "" "" "" "" "" "" "206.0" "169.8" "195.8" "148.5" "191.3" "204.1" "161.6" "168.6" "185.0" "208.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8875331277631851835" "False" "High" "IsMasterProtein" "O75113" "NEDD4-binding protein 1 OS=Homo sapiens OX=9606 GN=N4BP1 PE=1 SV=4" "0.000" "False" "6.387" "3" "3" "3" "3" "896" "100.3" "5.36" "7.76" "3" "stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf11977" "9683" "ENSG00000102921" "N4BP1" "A7MD49; hsa:9683; O75113; Q2YDX1" "" "Regulation of NF-kappa B signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3050786431982256186" "False" "High" "IsMasterProtein" "Q53ET0" "CREB-regulated transcription coactivator 2 OS=Homo sapiens OX=9606 GN=CRTC2 PE=1 SV=2" "0.000" "False" "6.383" "6" "3" "3" "3" "693" "73.3" "7.11" "9.87" "3" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12884, Pf12885, Pf12886" "200186" "ENSG00000160741" "CRTC2" "hsa:200186; Q53ET0; Q6UUV8; Q7Z3X7; Q8N332" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Circadian Clock; Heme signaling; Transcriptional activation of mitochondrial biogenesis" "5" "0" "0.968" "0.975" "0.941" "1.013" "1.044" "0.914" "0.900" "0.920" "1.009" "507.4" "491.2" "494.9" "477.4" "514.2" "529.8" "464.0" "456.7" "466.9" "512.0" "" "" "" "" "" "" "" "" "" "" "475.5" "406.4" "459.4" "369.0" "438.3" "506.2" "423.9" "405.5" "466.9" "493.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2898803308841595735" "False" "High" "IsMasterProtein" "O00182" "Galectin-9 OS=Homo sapiens OX=9606 GN=LGALS9 PE=1 SV=2" "0.000" "False" "6.380" "6" "3" "3" "3" "355" "39.5" "9.17" "7.73" "3" "stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00337" "3965" "ENSG00000168961" "LGALS9" "A7VJG6; F8W9W4; hsa:3965; O00182; O14532; O75028; Q3B8N1; Q53FQ0; Q8WYQ7; Q9NQ58" "Vitamin D receptor pathway; Pleural mesothelioma; Immune infiltration in pancreatic cancer" "Interleukin-2 family signaling" "4" "0" "0.973" "0.978" "1.057" "0.940" "1.026" "0.957" "0.985" "0.917" "0.976" "405.0" "393.9" "395.9" "427.9" "380.7" "415.6" "387.5" "399.0" "371.2" "395.3" "" "" "" "" "" "" "" "" "" "" "379.4" "326.0" "367.5" "330.8" "324.5" "397.1" "354.1" "354.3" "371.2" "380.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-631503824976752333" "False" "High" "IsMasterProtein" "Q9BYD2" "Large ribosomal subunit protein bL9m OS=Homo sapiens OX=9606 GN=MRPL9 PE=1 SV=2" "0.000" "False" "6.380" "9" "3" "3" "3" "267" "30.2" "10.08" "8.58" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01281" "65005" "ENSG00000143436" "MRPL9" "B2RD99; hsa:65005; Q5SZR2; Q9BSW8; Q9BYD2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.934" "0.936" "0.973" "0.917" "1.013" "0.946" "0.913" "0.853" "0.890" "366.2" "342.0" "342.7" "356.3" "335.8" "371.0" "346.3" "334.3" "312.4" "325.9" "" "" "" "" "" "" "" "" "" "" "343.1" "283.0" "318.2" "275.5" "286.3" "354.4" "316.5" "296.9" "312.4" "313.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5271819707192533656" "False" "High" "IsMasterProtein" "Q9H7E9" "UPF0488 protein C8orf33 OS=Homo sapiens OX=9606 GN=C8orf33 PE=1 SV=1" "0.000" "False" "6.377" "9" "2" "2" "2" "229" "25.0" "9.95" "7.16" "2" "" "" "" "Pf15393" "65265" "ENSG00000182307; ENSG00000291362" "C8orf33" "A6NGC0; hsa:65265; Q96BT8; Q9H7E9" "" "" "0" "0" "1.020" "0.991" "0.991" "1.051" "0.997" "0.957" "0.971" "0.952" "1.033" "600.8" "612.6" "595.6" "595.4" "631.2" "599.2" "575.3" "583.7" "572.1" "620.5" "" "" "" "" "" "" "" "" "" "" "563.0" "506.9" "553.0" "460.3" "538.0" "572.5" "525.7" "518.3" "572.1" "597.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4147874032451066507" "False" "High" "IsMasterProtein" "Q15036" "Sorting nexin-17 OS=Homo sapiens OX=9606 GN=SNX17 PE=1 SV=1" "0.000" "False" "6.376" "5" "2" "3" "2" "470" "52.9" "7.46" "7.61" "2" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf18116, Pf21271, Pf21273" "9784" "ENSG00000115234" "SNX17" "B4DQM7; hsa:9784; Q15036; Q53HN7; Q6IAS3" "" "" "0" "0" "1.112" "0.868" "1.177" "1.151" "0.944" "1.086" "0.942" "0.961" "1.024" "49.4" "54.9" "42.8" "58.1" "56.8" "46.6" "53.6" "46.5" "47.5" "50.6" "" "" "" "" "" "" "" "" "" "" "46.3" "45.4" "39.8" "44.9" "48.4" "44.5" "49.0" "41.3" "47.5" "48.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9165007621832030545" "False" "High" "IsMasterProtein" "Q7Z624" "Calmodulin-lysine N-methyltransferase OS=Homo sapiens OX=9606 GN=CAMKMT PE=1 SV=2" "0.000" "False" "6.374" "6" "2" "2" "2" "323" "36.1" "6.83" "6.17" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf10294" "79823" "ENSG00000143919" "CAMKMT" "hsa:79823; Q4ZG15; Q53SS6; Q7Z624; Q8N6P5; Q9H5G8" "" "Inactivation, recovery and regulation of the phototransduction cascade; Protein methylation" "2" "0" "1.116" "1.048" "1.137" "1.124" "1.028" "1.040" "1.021" "1.031" "1.083" "281.2" "314.0" "294.7" "319.8" "316.1" "289.0" "292.4" "287.3" "290.0" "304.7" "" "" "" "" "" "" "" "" "" "" "263.5" "259.8" "273.6" "247.2" "269.5" "276.2" "267.2" "255.1" "290.0" "293.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174147483962909046" "False" "High" "IsMasterProtein" "Q9NRX1" "RNA-binding protein PNO1 OS=Homo sapiens OX=9606 GN=PNO1 PE=1 SV=1" "0.000" "False" "6.373" "10" "3" "4" "3" "252" "27.9" "9.73" "8.78" "3" "other biological processes" "cytosol;nucleus;other cell component" "" "" "56902" "ENSG00000115946" "PNO1" "A8K6Q0; hsa:56902; Q53G13; Q8WVB8; Q9NRX1" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.019" "1.034" "1.091" "1.211" "1.150" "1.264" "1.369" "1.435" "1.196" "753.3" "767.9" "779.2" "822.2" "912.5" "866.6" "952.1" "1031.3" "1081.3" "901.3" "" "" "" "" "" "" "" "" "" "" "705.9" "635.4" "723.4" "635.6" "777.8" "827.9" "870.0" "915.7" "1081.3" "867.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5958552957432297313" "False" "High" "IsMasterProtein" "Q9BRJ6" "Uncharacterized protein C7orf50 OS=Homo sapiens OX=9606 GN=C7orf50 PE=1 SV=1" "0.000" "False" "6.368" "17" "2" "2" "2" "194" "22.1" "9.64" "9.57" "2" "" "" "" "Pf10180" "84310" "ENSG00000146540" "C7orf50" "Q9BRJ6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7984641138409737976" "False" "High" "IsMasterProtein" "Q9BXK5" "Bcl-2-like protein 13 OS=Homo sapiens OX=9606 GN=BCL2L13 PE=1 SV=1" "0.000" "False" "6.357" "4" "2" "3" "2" "485" "52.7" "4.44" "10.67" "2" "other biological processes" "other membranes;mitochondrion;nucleus" "enzyme regulator activity" "Pf00452" "23786" "ENSG00000099968" "BCL2L13" "B3KPE7; hsa:23786; Q96B37; Q96IB7; Q9BXK5; Q9BY01; Q9HC05; Q9UFE0; Q9UKN3" "Regulation of apoptosis by parathyroid hormone-related protein; TAR syndrome" "" "2" "0" "0.920" "0.991" "0.933" "0.991" "1.021" "1.016" "1.011" "1.007" "1.026" "513.5" "472.6" "508.7" "478.9" "509.1" "524.5" "521.8" "518.9" "517.0" "527.0" "" "" "" "" "" "" "" "" "" "" "481.1" "391.0" "472.3" "370.2" "433.9" "501.1" "476.8" "460.7" "517.0" "507.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1023835603968378243" "False" "High" "IsMasterProtein" "O75506" "Heat shock factor-binding protein 1 OS=Homo sapiens OX=9606 GN=HSBP1 PE=1 SV=1" "0.000" "False" "6.356" "39" "2" "2" "2" "76" "8.5" "4.36" "7.50" "2" "stress response;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06825" "3281" "ENSG00000230989" "HSBP1" "hsa:3281; O75506; Q53XA8; Q7Z5Z3" "" "HSF1 activation; Attenuation phase" "3" "0" "1.153" "0.943" "1.058" "1.013" "1.040" "1.046" "1.019" "0.926" "1.008" "429.8" "495.8" "405.3" "454.8" "435.5" "446.9" "449.5" "437.9" "398.2" "433.4" "" "" "" "" "" "" "" "" "" "" "402.8" "410.3" "376.3" "351.6" "371.2" "427.0" "410.7" "388.8" "398.2" "417.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3369989001081277177" "False" "High" "IsMasterProtein" "Q96CN9" "GRIP and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GCC1 PE=1 SV=1" "0.000" "False" "6.349" "2" "2" "2" "2" "775" "87.8" "5.45" "5.79" "2" "" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf01465" "79571" "ENSG00000179562" "GCC1" "hsa:79571; Q96CN9; Q9H6N7" "Nuclear receptors meta-pathway" "Retrograde transport at the Trans-Golgi-Network" "2" "0" "1.107" "1.003" "1.032" "1.041" "1.032" "0.961" "0.830" "0.925" "1.058" "73.6" "81.5" "73.8" "75.9" "76.6" "76.0" "70.7" "61.1" "68.1" "77.8" "" "" "" "" "" "" "" "" "" "" "69.0" "67.4" "68.5" "58.7" "65.3" "72.6" "64.6" "54.2" "68.1" "74.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1094871198918048732" "False" "High" "IsMasterProtein" "O00287" "Regulatory factor X-associated protein OS=Homo sapiens OX=9606 GN=RFXAP PE=1 SV=1" "0.000" "False" "6.337" "8" "2" "3" "2" "272" "28.2" "5.54" "9.80" "2" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf15289" "5994" "ENSG00000133111" "RFXAP" "B2R9T8; hsa:5994; O00287; Q5VZM6; Q8TC40" "" "" "0" "0" "1.124" "0.965" "1.159" "1.138" "0.974" "1.169" "1.109" "0.985" "1.004" "126.8" "142.5" "122.3" "146.9" "144.2" "123.5" "148.2" "140.5" "124.9" "127.2" "" "" "" "" "" "" "" "" "" "" "118.8" "117.9" "113.5" "113.6" "122.9" "118.0" "135.5" "124.8" "124.9" "122.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1616595542625436951" "False" "High" "IsMasterProtein" "Q96LR5" "Ubiquitin-conjugating enzyme E2 E2 OS=Homo sapiens OX=9606 GN=UBE2E2 PE=1 SV=1" "0.000" "False" "6.334" "8" "2" "4" "1" "201" "22.2" "7.71" "11.92" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00179" "7325" "ENSG00000182247" "UBE2E2" "hsa:7325; Q96LR5" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.972" "0.934" "0.970" "1.010" "0.911" "0.968" "1.009" "0.932" "0.978" "292.7" "284.4" "273.3" "283.9" "295.7" "266.5" "283.2" "295.3" "272.8" "286.4" "" "" "" "" "" "" "" "" "" "" "274.3" "235.3" "253.7" "219.5" "252.0" "254.6" "258.8" "262.2" "272.8" "275.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1540404723274759842" "False" "High" "IsMasterProtein" "P52333" "Tyrosine-protein kinase JAK3 OS=Homo sapiens OX=9606 GN=JAK3 PE=1 SV=2" "0.000" "False" "6.331" "3" "3" "3" "3" "1124" "125.0" "7.18" "7.92" "3" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf07714, Pf17887, Pf18377, Pf18379" "3718" "ENSG00000105639" "JAK3" "hsa:3718; P52333; Q13259; Q13260; Q13611; Q8N1E8; Q99699; Q9Y6S2" "IL-7 signaling pathway; IL-9 signaling pathway; Oncostatin M signaling pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Non-small cell lung cancer; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Measles virus infection; Hepatitis B infection; IL-2 signaling pathway" "Potential therapeutics for SARS; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; Interleukin-7 signaling; Signaling by ALK; Interleukin-4 and Interleukin-13 signaling; Interleukin-20 family signaling; Interleukin-2 signaling; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling" "24" "0" "1.162" "1.039" "1.135" "1.051" "0.993" "1.029" "0.956" "0.996" "1.005" "328.1" "381.2" "340.8" "372.5" "344.8" "325.7" "337.5" "313.5" "326.7" "329.8" "" "" "" "" "" "" "" "" "" "" "307.4" "315.4" "316.4" "288.0" "293.9" "311.1" "308.4" "278.3" "326.7" "317.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6202573485252222351" "False" "High" "IsMasterProtein" "Q9NZD2" "Glycolipid transfer protein OS=Homo sapiens OX=9606 GN=GLTP PE=1 SV=3" "0.000" "False" "6.320" "9" "2" "2" "2" "209" "23.8" "7.39" "6.44" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport" "cytosol" "transporter activity;other molecular function" "Pf08718" "51228" "ENSG00000139433" "GLTP" "hsa:51228; Q53Z13; Q96J68; Q9NZD2" "" "Glycosphingolipid transport" "1" "0" "0.993" "0.948" "1.156" "0.993" "0.933" "1.125" "0.932" "0.855" "0.974" "96.4" "95.7" "91.4" "111.4" "95.7" "89.9" "108.5" "89.8" "82.4" "93.9" "" "" "" "" "" "" "" "" "" "" "90.3" "79.2" "84.9" "86.1" "81.6" "85.9" "99.1" "79.8" "82.4" "90.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6959093533306709871" "False" "High" "IsMasterProtein" "P0DPD7" "EEF1A lysine methyltransferase 4 OS=Homo sapiens OX=9606 GN=EEF1AKMT4 PE=1 SV=1" "0.000" "False" "6.315" "9" "2" "2" "2" "255" "28.3" "6.05" "6.04" "2" "other metabolic processes" "" "other molecular function" "Pf08241" "110599564" "ENSG00000284753" "EEF1AKMT4" "A5PLK8; hsa:110599564; O60344; P0DPD7; Q6NTG7; Q6UW36; Q8NFD7; Q96NX3; Q96NX4; Q9BRZ8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3739657141075103728" "False" "High" "IsMasterProtein" "Q9NRN9" "rRNA N6-adenosine-methyltransferase METTL5 OS=Homo sapiens OX=9606 GN=METTL5 PE=1 SV=1" "0.000" "False" "6.305" "11" "2" "2" "2" "209" "23.7" "6.68" "5.65" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05175" "29081" "ENSG00000138382" "METTL5" "D3DPC9; hsa:29081; Q9NRN9; Q9NVX1" "" "" "0" "0" "1.228" "1.373" "1.783" "1.544" "1.430" "1.433" "1.419" "1.245" "1.317" "37.3" "45.8" "51.2" "66.5" "57.6" "53.4" "53.5" "52.9" "46.4" "49.1" "" "" "" "" "" "" "" "" "" "" "35.0" "37.9" "47.6" "51.4" "49.1" "51.0" "48.9" "47.0" "46.4" "47.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8410241835469765050" "False" "High" "IsMasterProtein" "Q9Y2G2" "Caspase recruitment domain-containing protein 8 OS=Homo sapiens OX=9606 GN=CARD8 PE=1 SV=2" "0.000" "False" "6.303" "3" "2" "2" "2" "537" "60.6" "4.84" "6.10" "2" "cell organization and biogenesis;protein metabolism;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf13553" "22900" "ENSG00000105483" "CARD8" "B5KVR6; B5KVR8; B7Z496; B7Z4A2; E5RFV9; E9PEM7; G3XAM9; hsa:22900; Q6PGP8; Q96P82; Q9Y2G2" "Nucleotide-binding oligomerization domain (NOD) pathway" "Regulation of the apoptosome activity" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "338471368414013319" "False" "High" "IsMasterProtein" "Q96T60" "Bifunctional polynucleotide phosphatase/kinase OS=Homo sapiens OX=9606 GN=PNKP PE=1 SV=1" "0.000" "False" "6.301" "5" "3" "3" "3" "521" "57.0" "8.46" "7.77" "3" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf08645, Pf13671, Pf17913" "11284" "ENSG00000039650" "PNKP" "hsa:11284; Q96T60; Q9BUL2; Q9P1V2; Q9UKU8; Q9UNF8; Q9UNI0" "Base excision repair; DNA repair pathways, full network" "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway" "3" "0" "0.990" "1.022" "1.024" "1.024" "1.085" "1.014" "1.061" "0.973" "1.057" "291.6" "288.6" "297.9" "298.7" "298.6" "316.4" "295.5" "309.3" "283.6" "308.2" "" "" "" "" "" "" "" "" "" "" "273.2" "238.8" "276.6" "230.9" "254.6" "302.3" "270.0" "274.7" "283.6" "296.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-985181273239411309" "False" "High" "IsMasterProtein" "Q5JUR7" "Testis-expressed protein 30 OS=Homo sapiens OX=9606 GN=TEX30 PE=1 SV=1" "0.000" "False" "6.300" "11" "3" "3" "3" "227" "25.6" "8.66" "5.24" "3" "" "" "" "Pf20408" "93081" "ENSG00000151287" "TEX30" "hsa:93081; Q5JUR7; Q5JUR8; Q96KZ8" "" "" "0" "0" "1.168" "1.147" "1.297" "1.189" "1.174" "1.177" "1.131" "1.137" "1.079" "144.7" "169.0" "166.0" "187.6" "172.1" "169.8" "170.3" "163.7" "164.5" "156.1" "" "" "" "" "" "" "" "" "" "" "135.6" "139.8" "154.1" "145.0" "146.7" "162.2" "155.6" "145.4" "164.5" "150.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9075280951894741873" "False" "High" "IsMasterProtein" "Q9NQP4" "Prefoldin subunit 4 OS=Homo sapiens OX=9606 GN=PFDN4 PE=1 SV=1" "0.000" "False" "6.300" "20" "2" "5" "2" "134" "15.3" "4.53" "16.52" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01920" "5203" "ENSG00000101132" "PFDN4" "hsa:5203; Q5TD11; Q92779; Q9NQP4" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "1.163" "0.949" "1.134" "1.021" "1.041" "1.186" "1.120" "0.975" "1.003" "152.0" "176.8" "144.2" "172.3" "155.2" "158.2" "180.3" "170.2" "148.2" "152.4" "" "" "" "" "" "" "" "" "" "" "142.4" "146.3" "133.9" "133.2" "132.3" "151.2" "164.7" "151.2" "148.2" "146.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5495353831656127209" "False" "High" "IsMasterProtein" "Q8ND04" "Nonsense-mediated mRNA decay factor SMG8 OS=Homo sapiens OX=9606 GN=SMG8 PE=1 SV=1" "0.000" "False" "6.295" "2" "2" "3" "2" "991" "109.6" "7.68" "9.82" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol" "" "Pf10220" "55181" "ENSG00000167447" "SMG8" "hsa:55181; Q8N5U5; Q8ND04; Q8TDN0; Q9H5P5; Q9NVQ1" "" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "1" "0" "0.972" "0.990" "0.997" "1.001" "0.934" "0.991" "0.919" "0.937" "1.009" "317.7" "308.8" "314.4" "316.8" "318.0" "296.7" "314.7" "291.8" "297.6" "320.6" "" "" "" "" "" "" "" "" "" "" "297.7" "255.5" "291.9" "244.9" "271.1" "283.5" "287.5" "259.1" "297.6" "308.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7180208613807174562" "False" "High" "IsMasterProtein" "P16118" "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 OS=Homo sapiens OX=9606 GN=PFKFB1 PE=1 SV=3" "0.000" "False" "6.287" "7" "3" "5" "1" "471" "54.6" "6.58" "11.66" "3" "other metabolic processes;stress response;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf00300, Pf01591" "5207" "ENSG00000158571" "PFKFB1" "B2RA88; B4DUN5; hsa:5207; P16118; Q5JXS5; Q99951" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; PKA-mediated phosphorylation of key metabolic factors; PP2A-mediated dephosphorylation of key metabolic factors" "4" "0" "0.931" "1.055" "0.842" "0.911" "0.959" "0.863" "0.899" "0.987" "1.037" "454.0" "422.6" "479.0" "382.2" "413.6" "435.4" "392.0" "408.0" "448.0" "471.0" "" "" "" "" "" "" "" "" "" "" "425.4" "349.7" "444.7" "295.4" "352.6" "416.0" "358.2" "362.3" "448.0" "453.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3436560803263431899" "False" "High" "IsMasterProtein" "P14921" "Protein C-ets-1 OS=Homo sapiens OX=9606 GN=ETS1 PE=1 SV=1" "0.000" "False" "6.278" "4" "2" "2" "2" "441" "50.4" "5.19" "6.90" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198, Pf19525" "2113" "ENSG00000134954" "ETS1" "A9UL17; F5GYX9; hsa:2113; P14921; Q14278; Q16080; Q6N087; Q96AC5" "Neural crest differentiation; B cell receptor signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; MET in type 1 papillary renal cell carcinoma; Ras signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Melanoma; Extrafollicular and follicular B cell activation by SARS-CoV-2" "Oncogene Induced Senescence" "11" "0" "1.047" "1.081" "1.030" "0.998" "0.985" "0.811" "0.834" "0.811" "0.976" "284.5" "298.0" "307.6" "293.0" "284.1" "280.4" "230.7" "237.4" "230.7" "277.6" "" "" "" "" "" "" "" "" "" "" "266.6" "246.6" "285.6" "226.5" "242.1" "267.9" "210.8" "210.8" "230.7" "267.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4714570572578111777" "False" "High" "IsMasterProtein" "Q86YS6" "Ras-related protein Rab-43 OS=Homo sapiens OX=9606 GN=RAB43 PE=1 SV=1" "0.000" "False" "6.276" "10" "2" "2" "1" "212" "23.3" "5.64" "6.40" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00071" "339122" "ENSG00000172780" "RAB43" "A8K4P9; E9PBQ0; hsa:339122; Q86YS6" "" "RAB geranylgeranylation; Retrograde transport at the Trans-Golgi-Network" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6434237713970420089" "False" "High" "IsMasterProtein" "Q9Y291" "Small ribosomal subunit protein mS33 OS=Homo sapiens OX=9606 GN=MRPS33 PE=1 SV=1" "0.000" "False" "6.270" "19" "2" "3" "2" "106" "12.6" "10.11" "7.68" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf08293" "51650" "ENSG00000090263" "MRPS33" "hsa:51650; Q9Y291" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.914" "0.972" "0.874" "1.776" "1.980" "1.483" "1.131" "2.144" "1.347" "130.9" "119.6" "127.2" "114.4" "232.4" "259.1" "194.0" "148.0" "280.5" "176.2" "" "" "" "" "" "" "" "" "" "" "122.6" "99.0" "118.1" "88.4" "198.1" "247.5" "177.3" "131.4" "280.5" "169.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5372839880175933062" "False" "High" "IsMasterProtein" "Q9NUK0" "Muscleblind-like protein 3 OS=Homo sapiens OX=9606 GN=MBNL3 PE=1 SV=2" "0.000" "False" "6.258" "6" "2" "2" "1" "354" "38.5" "8.81" "6.27" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf14608, Pf18044" "55796" "ENSG00000076770" "MBNL3" "hsa:55796; Q5JXN8; Q5JXN9; Q5JXP4; Q6UDQ1; Q8IUR4; Q8TAD9; Q8TAF4; Q9H0Z7; Q9NUK0; Q9UF37" "" "" "0" "0" "0.981" "1.141" "1.207" "1.096" "1.072" "1.017" "1.119" "1.072" "1.019" "97.2" "95.3" "110.9" "117.3" "106.5" "104.2" "98.9" "108.7" "104.2" "99.0" "" "" "" "" "" "" "" "" "" "" "91.1" "78.9" "102.9" "90.7" "90.8" "99.5" "90.3" "96.5" "104.2" "95.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400072782813286453" "False" "High" "IsMasterProtein" "P62424" "Large ribosomal subunit protein eL8 OS=Homo sapiens OX=9606 GN=RPL7A PE=1 SV=2" "0.000" "False" "6.257" "9" "3" "3" "3" "266" "30.0" "10.61" "9.41" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6130" "ENSG00000148303; ENSG00000280858" "RPL7A" "hsa:6130; P11518; P62424; Q5T8U4" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.982" "1.030" "1.002" "1.071" "1.015" "1.051" "0.952" "0.949" "1.070" "934.9" "917.8" "962.8" "936.5" "1001.4" "948.9" "982.2" "889.9" "887.7" "1000.6" "" "" "" "" "" "" "" "" "" "" "876.0" "759.4" "893.8" "724.0" "853.6" "906.5" "897.5" "790.2" "887.7" "963.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4910055014827061803" "False" "High" "IsMasterProtein" "Q14653" "Interferon regulatory factor 3 OS=Homo sapiens OX=9606 GN=IRF3 PE=1 SV=1" "0.000" "False" "6.256" "6" "2" "7" "2" "427" "47.2" "5.34" "11.07" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3661" "ENSG00000126456" "IRF3" "A8K7L2; B2RAZ3; hsa:3661; Q14653; Q5FBY1; Q5FBY2; Q5FBY4; Q7Z5G6" "Apoptosis; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; Fibrin complement receptor 3 signaling pathway; White fat cell differentiation; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19; Urotensin-II-mediated signaling pathway; Induction of autophagy and toll-like receptor signaling pathways by graphene oxide ; Toll-like receptor signaling pathway" "Interferon gamma signaling; Regulation of innate immune responses to cytosolic DNA; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Negative regulators of DDX58/IFIH1 signaling; TICAM1-dependent activation of IRF3/IRF7; SARS-CoV-1 activates/modulates innate immune responses; TRAF3-dependent IRF activation pathway; ISG15 antiviral mechanism; Interferon alpha/beta signaling; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; IRF3-mediated induction of type I IFN; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; IRF3 mediated activation of type 1 IFN" "38" "0" "1.014" "0.956" "1.113" "1.000" "1.013" "0.996" "0.990" "0.969" "0.973" "259.9" "263.7" "248.4" "289.3" "260.0" "263.2" "259.0" "257.3" "251.8" "252.9" "" "" "" "" "" "" "" "" "" "" "243.5" "218.2" "230.6" "223.6" "221.6" "251.5" "236.6" "228.4" "251.8" "243.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4297435359722797915" "False" "High" "IsMasterProtein" "Q99755" "Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha OS=Homo sapiens OX=9606 GN=PIP5K1A PE=1 SV=1" "0.000" "False" "6.248" "4" "3" "3" "3" "562" "62.6" "8.21" "8.90" "3" "cell adhesion;cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01504" "8394" "ENSG00000143398" "PIP5K1A" "A8K4Q0; B4DIN0; hsa:8394; Q99754; Q99755; Q99756" "B cell receptor signaling pathway; Regulation of actin cytoskeleton" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8787023427386069087" "False" "High" "IsMasterProtein" "P53365" "Arfaptin-2 OS=Homo sapiens OX=9606 GN=ARFIP2 PE=1 SV=1" "0.000" "False" "6.244" "5" "2" "3" "1" "341" "37.8" "6.04" "6.22" "2" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06456" "23647" "ENSG00000132254" "ARFIP2" "B4DX86; B4E306; D3DQT5; hsa:23647; P53365" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5305679341133587567" "False" "High" "IsMasterProtein" "Q86WR0" "Coiled-coil domain-containing protein 25 OS=Homo sapiens OX=9606 GN=CCDC25 PE=1 SV=2" "0.000" "False" "6.238" "8" "2" "3" "2" "208" "24.5" "6.80" "8.87" "2" "other biological processes" "plasma membrane;other membranes;other cell component" "nucleic acid binding activity" "Pf05670" "55246" "ENSG00000147419" "CCDC25" "hsa:55246; Q0P663; Q86WR0; Q96SI2; Q9NV98" "" "" "0" "0" "0.931" "0.928" "1.003" "0.946" "0.916" "0.941" "0.961" "0.897" "0.977" "508.0" "473.2" "471.2" "509.7" "480.7" "465.2" "478.0" "488.1" "455.5" "496.5" "" "" "" "" "" "" "" "" "" "" "476.0" "391.6" "437.5" "394.0" "409.8" "444.4" "436.7" "433.4" "455.5" "478.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6903887554392062573" "False" "High" "IsMasterProtein" "P35226" "Polycomb complex protein BMI-1 OS=Homo sapiens OX=9606 GN=BMI1 PE=1 SV=2" "0.000" "False" "6.220" "7" "3" "4" "3" "326" "36.9" "8.63" "12.95" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf13923, Pf16207" "100532731; 648" "ENSG00000168283" "BMI1" "hsa:100532731; hsa:648; P35226; Q16030; Q5T8Z3; Q96F37" "Pleural mesothelioma; Interactions of natural killer cells in pancreatic cancer; CCL18 signaling pathway" "SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6" "12" "0" "0.934" "1.009" "0.969" "1.007" "1.032" "1.065" "1.135" "1.048" "0.991" "397.3" "371.2" "400.9" "385.0" "400.1" "410.1" "423.3" "450.9" "416.3" "393.6" "" "" "" "" "" "" "" "" "" "" "372.2" "307.2" "372.2" "297.6" "341.0" "391.8" "386.8" "400.3" "416.3" "379.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2974219725755957834" "False" "High" "IsMasterProtein" "Q5HYJ3" "Protein FAM76B OS=Homo sapiens OX=9606 GN=FAM76B PE=1 SV=3" "0.000" "False" "6.216" "5" "2" "2" "2" "339" "38.7" "9.25" "7.89" "2" "" "nucleus" "" "Pf16046" "143684" "ENSG00000077458" "FAM76B" "B2R9C2; hsa:143684; Q5HYJ3; Q6PIU3; Q8TC53" "" "" "0" "0" "1.063" "0.954" "0.973" "1.078" "1.167" "1.129" "1.236" "1.238" "1.018" "196.4" "208.8" "187.3" "191.0" "211.7" "229.2" "221.7" "242.8" "243.0" "200.0" "" "" "" "" "" "" "" "" "" "" "184.0" "172.8" "173.9" "147.7" "180.4" "219.0" "202.6" "215.6" "243.0" "192.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1078046361948541096" "False" "High" "IsMasterProtein" "Q6UWP2" "Dehydrogenase/reductase SDR family member 11 OS=Homo sapiens OX=9606 GN=DHRS11 PE=1 SV=1" "0.000" "False" "6.212" "7" "2" "2" "2" "260" "28.3" "6.64" "7.59" "2" "other metabolic processes" "non-structural extracellular" "other molecular function" "Pf00106" "79154" "ENSG00000275397; ENSG00000278535" "DHRS11" "A0A0U5BLD0; B2RDZ3; hsa:79154; Q6UWP2; Q9BUC7; Q9H674" "17q12 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4792290450889044309" "False" "High" "IsMasterProtein" "Q96IV0" "Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Homo sapiens OX=9606 GN=NGLY1 PE=1 SV=1" "0.000" "False" "6.199" "3" "3" "4" "3" "654" "74.3" "6.89" "11.06" "3" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01841, Pf04721, Pf09409" "55768" "ENSG00000151092" "NGLY1" "B4DJE9; hsa:55768; Q59FB1; Q6PJD8; Q96IV0; Q9BVR8; Q9NR70" "" "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "1" "0" "1.014" "0.977" "0.980" "1.044" "1.018" "0.936" "1.063" "0.977" "1.052" "287.3" "291.4" "280.8" "281.5" "300.0" "292.4" "269.0" "305.3" "280.6" "302.2" "" "" "" "" "" "" "" "" "" "" "269.2" "241.2" "260.7" "217.6" "255.7" "279.4" "245.8" "271.1" "280.6" "290.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8388783144784420231" "False" "High" "IsMasterProtein" "P82930" "Small ribosomal subunit protein mS34 OS=Homo sapiens OX=9606 GN=MRPS34 PE=1 SV=2" "0.000" "False" "6.197" "10" "3" "4" "3" "218" "25.6" "9.98" "9.99" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf16053" "65993" "ENSG00000074071" "MRPS34" "hsa:65993; P82930; Q9BVI7" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-776165374606149247" "False" "High" "IsMasterProtein" "Q99547" "M-phase phosphoprotein 6 OS=Homo sapiens OX=9606 GN=MPHOSPH6 PE=1 SV=2" "0.000" "False" "6.185" "16" "3" "3" "3" "160" "19.0" "5.20" "10.22" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf10175" "10200" "ENSG00000135698" "MPHOSPH6" "B2RAF0; hsa:10200; Q99547" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "0.987" "1.046" "0.935" "1.062" "1.034" "1.003" "1.050" "1.012" "1.021" "767.5" "757.2" "802.9" "717.5" "815.3" "793.7" "770.1" "805.6" "776.5" "783.5" "" "" "" "" "" "" "" "" "" "" "719.1" "626.6" "745.4" "554.7" "694.9" "758.3" "703.7" "715.3" "776.5" "754.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-626678755710490294" "False" "High" "IsMasterProtein" "O14593" "DNA-binding protein RFXANK OS=Homo sapiens OX=9606 GN=RFXANK PE=1 SV=2" "0.000" "False" "6.179" "9" "2" "4" "2" "260" "28.1" "4.55" "10.22" "2" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00023" "8625" "ENSG00000064490" "RFXANK" "hsa:8625; O14593; O95839; Q24JQ1; Q6FGA8" "" "" "0" "0" "1.375" "1.009" "1.459" "1.205" "1.159" "1.381" "1.097" "1.754" "1.303" "23.4" "32.1" "23.6" "34.1" "28.1" "27.1" "32.3" "25.6" "41.0" "30.4" "" "" "" "" "" "" "" "" "" "" "21.9" "26.6" "21.9" "26.3" "24.0" "25.9" "29.5" "22.8" "41.0" "29.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3974339187776743055" "False" "High" "IsMasterProtein" "Q93074" "Mediator of RNA polymerase II transcription subunit 12 OS=Homo sapiens OX=9606 GN=MED12 PE=1 SV=4" "0.000" "False" "6.172" "1" "3" "3" "3" "2177" "242.9" "7.05" "6.87" "3" "cell-cell signaling;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09497, Pf12144, Pf12145" "9968" "ENSG00000184634" "MED12" "hsa:9968; O15410; O75557; Q93074; Q9UHV6; Q9UND7" "" "PPARA activates gene expression; Generic Transcription Pathway; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "4" "0" "1.501" "0.897" "1.521" "1.319" "1.053" "1.271" "0.979" "1.070" "1.056" "259.7" "390.0" "233.0" "394.9" "342.7" "273.5" "330.2" "254.3" "277.8" "274.4" "" "" "" "" "" "" "" "" "" "" "243.3" "322.7" "216.3" "305.3" "292.1" "261.3" "301.7" "225.8" "277.8" "264.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5130532040742567239" "False" "High" "IsMasterProtein" "Q9HCN8" "Stromal cell-derived factor 2-like protein 1 OS=Homo sapiens OX=9606 GN=SDF2L1 PE=1 SV=2" "0.000" "False" "6.169" "10" "2" "3" "2" "221" "23.6" "7.03" "8.14" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf02815" "23753" "ENSG00000128228" "SDF2L1" "A2RUD3; hsa:23753; Q9BRI5; Q9HCN8" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.953" "0.941" "0.887" "1.024" "1.045" "0.912" "0.923" "0.946" "0.914" "177.6" "169.2" "167.0" "157.5" "181.8" "185.5" "162.0" "163.9" "168.0" "162.3" "" "" "" "" "" "" "" "" "" "" "166.4" "140.0" "155.1" "121.8" "155.0" "177.3" "148.0" "145.5" "168.0" "156.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "765579875042607640" "False" "High" "IsMasterProtein" "Q15843" "NEDD8 OS=Homo sapiens OX=9606 GN=NEDD8 PE=1 SV=1" "0.000" "False" "6.160" "25" "2" "4" "2" "81" "9.1" "8.43" "11.25" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00240" "4738" "ENSG00000129559; ENSG00000285246" "NEDD8" "hsa:4738; Q15843; Q3SXN8; Q6LES6" "EGF/EGFR signaling pathway; 2q37 copy number variation syndrome" "UCH proteinases; Neddylation; Cargo recognition for clathrin-mediated endocytosis; Iron uptake and transport; TGF-beta receptor signaling activates SMADs" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4471823552801457794" "False" "High" "IsMasterProtein" "Q9GZN1" "Actin-related protein 6 OS=Homo sapiens OX=9606 GN=ACTR6 PE=1 SV=1" "0.000" "False" "6.158" "6" "2" "3" "2" "396" "45.8" "5.03" "9.03" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00022" "64431" "ENSG00000075089" "ACTR6" "B3KW37; B4DLG9; hsa:64431; Q53GH2; Q9BY39; Q9GZN1; Q9H8H6" "" "" "0" "0" "0.912" "1.122" "1.141" "1.271" "1.124" "1.103" "1.099" "1.069" "1.202" "112.5" "102.6" "126.2" "128.4" "142.9" "126.4" "124.1" "123.6" "120.3" "135.2" "" "" "" "" "" "" "" "" "" "" "105.4" "84.9" "117.2" "99.3" "121.8" "120.8" "113.4" "109.8" "120.3" "130.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8979611846707191829" "False" "High" "IsMasterProtein" "O76080" "AN1-type zinc finger protein 5 OS=Homo sapiens OX=9606 GN=ZFAND5 PE=1 SV=1" "0.000" "False" "6.150" "8" "2" "2" "2" "213" "23.1" "8.51" "7.72" "2" "developmental processes;signal transduction;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf01428, Pf01754" "7763" "ENSG00000107372" "ZFAND5" "A8K484; hsa:7763; O76080" "" "" "0" "0" "1.036" "0.990" "0.910" "0.971" "0.992" "0.882" "0.855" "0.871" "0.919" "393.6" "407.6" "389.6" "358.3" "382.1" "390.5" "347.1" "336.5" "342.7" "361.7" "" "" "" "" "" "" "" "" "" "" "368.8" "337.3" "361.7" "277.0" "325.7" "373.1" "317.1" "298.8" "342.7" "348.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4887773767884950166" "False" "High" "IsMasterProtein" "Q68DK7" "Male-specific lethal 1 homolog OS=Homo sapiens OX=9606 GN=MSL1 PE=1 SV=3" "0.000" "False" "6.149" "3" "2" "2" "2" "614" "67.1" "8.92" "6.98" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15275, Pf16801" "339287" "ENSG00000188895" "MSL1" "hsa:339287; Q0VF46; Q68DK7; Q69Z03" "" "HATs acetylate histones" "1" "0" "1.502" "1.304" "1.264" "1.402" "1.231" "1.282" "1.121" "1.160" "1.148" "147.1" "220.9" "191.8" "185.9" "206.2" "181.1" "188.6" "164.9" "170.7" "168.8" "" "" "" "" "" "" "" "" "" "" "137.8" "182.8" "178.1" "143.7" "175.8" "173.0" "172.3" "146.4" "170.7" "162.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7065461624018501642" "False" "High" "IsMasterProtein" "Q96JB5" "CDK5 regulatory subunit-associated protein 3 OS=Homo sapiens OX=9606 GN=CDK5RAP3 PE=1 SV=2" "0.000" "False" "6.141" "6" "3" "4" "3" "506" "56.9" "4.75" "6.97" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05600" "80279" "ENSG00000108465" "CDK5RAP3" "B7Z6N4; D3DTU1; D3DTU2; F5H3I5; hsa:80279; Q53FA2; Q96JB5; Q9H3F8; Q9H8G0; Q9HBR9" "" "" "0" "0" "1.172" "1.040" "1.146" "0.948" "1.072" "1.008" "1.055" "0.947" "1.073" "110.6" "129.6" "115.0" "126.7" "104.8" "118.5" "111.5" "116.7" "104.8" "118.6" "" "" "" "" "" "" "" "" "" "" "103.6" "107.2" "106.7" "98.0" "89.4" "113.2" "101.8" "103.6" "104.8" "114.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8852337030398889599" "False" "High" "IsMasterProtein" "C9JRZ8" "Aldo-keto reductase family 1 member B15 OS=Homo sapiens OX=9606 GN=AKR1B15 PE=1 SV=2" "0.000" "False" "6.133" "8" "2" "4" "1" "316" "36.5" "6.70" "11.90" "2" "other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00248" "441282" "ENSG00000227471" "AKR1B15" "C9J3V2; C9JRZ8; hsa:441282" "" "Estrogen biosynthesis" "1" "0" "1.101" "1.088" "0.854" "1.123" "1.120" "0.900" "1.107" "1.228" "1.163" "122.5" "134.8" "133.2" "104.6" "137.6" "137.2" "110.2" "135.6" "150.4" "142.5" "" "" "" "" "" "" "" "" "" "" "114.8" "111.5" "123.7" "80.9" "117.2" "131.1" "100.7" "120.4" "150.4" "137.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4485483695822680049" "False" "High" "IsMasterProtein" "Q9Y5R8" "Trafficking protein particle complex subunit 1 OS=Homo sapiens OX=9606 GN=TRAPPC1 PE=1 SV=1" "0.000" "False" "6.133" "12" "2" "4" "2" "145" "16.8" "9.16" "11.37" "2" "cell organization and biogenesis;transport" "non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04099" "58485" "ENSG00000170043" "TRAPPC1" "D3DTR0; hsa:58485; Q9Y5R8" "" "COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation" "3" "0" "1.091" "1.018" "1.072" "1.055" "1.042" "0.965" "0.989" "1.035" "1.006" "320.6" "349.8" "326.3" "343.7" "338.2" "334.0" "309.4" "317.2" "332.0" "322.5" "" "" "" "" "" "" "" "" "" "" "300.4" "289.4" "302.9" "265.7" "288.2" "319.1" "282.7" "281.6" "332.0" "310.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2746028524908130600" "False" "High" "IsMasterProtein" "P16070" "CD44 antigen OS=Homo sapiens OX=9606 GN=CD44 PE=1 SV=3" "0.000" "False" "6.130" "3" "2" "2" "2" "742" "81.5" "5.33" "7.08" "2" "cell adhesion;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00193" "960" "ENSG00000026508" "CD44" "A5YRN9; B6EAT9; D3DR12; D3DR13; hsa:960; O95370; P16070; P22511; Q04858; Q13419; Q13957; Q13958; Q13959; Q13960; Q13961; Q13967; Q13968; Q13980; Q15861; Q16064; Q16065; Q16066; Q16208; Q16522; Q86T72; Q86Z27; Q8N694; Q92493; Q96J24; Q9H5A5; Q9UC28; Q9UC29; Q9UC30; Q9UCB0; Q9UJ36" "Hepatitis C and hepatocellular carcinoma; Wnt signaling pathway and pluripotency; Hippo-Merlin signaling dysregulation; Gastrin signaling pathway; Pleural mesothelioma; CCL18 signaling pathway" "Neutrophil degranulation; Cell surface interactions at the vascular wall; Degradation of the extracellular matrix; Integrin cell surface interactions; Interferon gamma signaling; Hyaluronan uptake and degradation" "12" "0" "1.088" "1.075" "1.002" "1.023" "1.043" "1.067" "1.021" "0.949" "1.030" "221.4" "240.9" "238.0" "221.8" "226.4" "231.0" "236.1" "225.9" "210.1" "228.0" "" "" "" "" "" "" "" "" "" "" "207.4" "199.3" "221.0" "171.4" "193.0" "220.7" "215.8" "200.6" "210.1" "219.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1535429357355427418" "False" "High" "IsMasterProtein" "Q9UL25" "Ras-related protein Rab-21 OS=Homo sapiens OX=9606 GN=RAB21 PE=1 SV=3" "0.000" "False" "6.128" "9" "2" "2" "2" "225" "24.3" "7.94" "5.57" "2" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "23011" "ENSG00000080371" "RAB21" "hsa:23011; Q14466; Q569H3; Q9UL25" "Ciliary landscape" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation" "3" "0" "1.044" "0.973" "1.158" "0.999" "0.893" "0.970" "1.000" "0.926" "0.951" "329.4" "344.0" "320.6" "381.5" "329.1" "294.3" "319.5" "329.3" "305.2" "313.4" "" "" "" "" "" "" "" "" "" "" "308.7" "284.6" "297.6" "294.9" "280.5" "281.2" "291.9" "292.4" "305.2" "301.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7099090004337322375" "False" "High" "IsMasterProtein" "P63167" "Dynein light chain 1, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL1 PE=1 SV=1" "0.000" "False" "6.124" "33" "2" "3" "2" "89" "10.4" "7.40" "10.00" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01221" "8655" "ENSG00000088986" "DYNLL1" "hsa:8655; P63167; Q15701" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome; Vasopressin-regulated water reabsorption" "Neutrophil degranulation; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Intraflagellar transport; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Macroautophagy; Activation of BIM and translocation to mitochondria" "28" "0" "1.131" "1.047" "1.261" "1.068" "1.123" "1.112" "0.964" "1.167" "1.104" "244.0" "275.9" "255.3" "307.7" "260.6" "273.9" "271.4" "235.1" "284.7" "269.4" "" "" "" "" "" "" "" "" "" "" "228.6" "228.3" "237.0" "237.9" "222.1" "261.7" "248.0" "208.8" "284.7" "259.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4846678346596657924" "False" "High" "IsMasterProtein" "Q7L775" "EPM2A-interacting protein 1 OS=Homo sapiens OX=9606 GN=EPM2AIP1 PE=1 SV=1" "0.000" "False" "6.123" "4" "3" "4" "3" "607" "70.3" "6.11" "8.11" "3" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf18658" "9852" "ENSG00000178567" "EPM2AIP1" "hsa:9852; O94866; Q7L775; Q9H3L3" "" "" "0" "0" "0.963" "0.963" "1.005" "0.995" "1.011" "1.016" "0.942" "0.906" "0.879" "238.3" "229.6" "229.5" "239.6" "237.1" "241.0" "242.1" "224.4" "216.0" "209.6" "" "" "" "" "" "" "" "" "" "" "223.3" "190.0" "213.0" "185.2" "202.1" "230.3" "221.2" "199.3" "216.0" "201.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5842118922115640430" "False" "High" "IsMasterProtein" "P36405" "ADP-ribosylation factor-like protein 3 OS=Homo sapiens OX=9606 GN=ARL3 PE=1 SV=2" "0.000" "False" "6.109" "10" "2" "3" "2" "182" "20.4" "7.24" "10.12" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00025" "403" "ENSG00000138175" "ARL3" "B2R6C7; hsa:403; P36405; Q53X83; Q5JSM2" "Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "Trafficking of myristoylated proteins to the cilium" "5" "0" "1.099" "0.959" "1.119" "1.075" "1.119" "1.031" "0.984" "0.955" "1.043" "154.6" "169.8" "148.3" "172.9" "166.2" "173.0" "159.4" "152.0" "147.7" "161.2" "" "" "" "" "" "" "" "" "" "" "144.8" "140.5" "137.6" "133.7" "141.7" "165.3" "145.6" "135.0" "147.7" "155.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1537630137721928118" "False" "High" "IsMasterProtein" "Q8IU60" "m7GpppN-mRNA hydrolase OS=Homo sapiens OX=9606 GN=DCP2 PE=1 SV=3" "0.000" "False" "6.109" "5" "2" "2" "2" "420" "48.4" "8.00" "5.68" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293, Pf05026" "167227" "ENSG00000172795" "DCP2" "C9J778; hsa:167227; Q6P2D4; Q7Z5W5; Q8IU60; Q8NBG5" "" "mRNA decay by 5' to 3' exoribonuclease; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7398915680383575894" "False" "High" "IsMasterProtein" "Q5BKX5" "Actin maturation protease OS=Homo sapiens OX=9606 GN=ACTMAP PE=1 SV=2" "0.000" "False" "6.105" "7" "2" "2" "2" "351" "37.8" "7.47" "6.85" "2" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf21646" "284325" "ENSG00000188493" "ACTMAP" "A8MSZ5; B4DNU7; hsa:284325; Q5BKX5" "" "" "0" "0" "0.989" "0.960" "1.098" "1.022" "1.019" "0.980" "0.868" "1.015" "1.031" "283.3" "280.1" "272.1" "310.9" "289.5" "288.8" "277.5" "246.0" "287.6" "292.1" "" "" "" "" "" "" "" "" "" "" "265.5" "231.8" "252.6" "240.4" "246.7" "275.9" "253.6" "218.5" "287.6" "281.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6803937283949644789" "False" "High" "IsMasterProtein" "O15381" "Nuclear valosin-containing protein-like OS=Homo sapiens OX=9606 GN=NVL PE=1 SV=1" "0.000" "False" "6.098" "3" "3" "3" "3" "856" "95.0" "6.48" "7.42" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00004, Pf16725, Pf17862" "4931" "ENSG00000143748" "NVL" "B4DMC4; B4DP98; hsa:4931; O15381; Q96EM7" "" "" "0" "0" "0.971" "0.984" "1.092" "1.058" "1.045" "1.180" "1.156" "1.068" "0.985" "359.0" "348.6" "353.3" "391.9" "379.8" "375.1" "423.7" "415.0" "383.5" "353.8" "" "" "" "" "" "" "" "" "" "" "336.4" "288.5" "328.0" "302.9" "323.7" "358.4" "387.1" "368.5" "383.5" "340.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6853827814974880096" "False" "High" "IsMasterProtein" "P52747" "Zinc finger protein 143 OS=Homo sapiens OX=9606 GN=ZNF143 PE=1 SV=2" "0.000" "False" "6.091" "3" "2" "2" "2" "638" "68.9" "6.05" "6.56" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "7702" "ENSG00000166478" "ZNF143" "A8K518; B4DLY5; E7ER34; hsa:7702; O75559; P52747; Q8WUK9" "IL-18 signaling pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes" "4" "0" "1.052" "1.078" "1.119" "1.077" "1.074" "1.019" "0.956" "1.007" "1.054" "181.3" "190.8" "195.5" "203.0" "195.4" "194.8" "184.7" "173.4" "182.7" "191.0" "" "" "" "" "" "" "" "" "" "" "169.9" "157.9" "181.5" "156.9" "166.5" "186.1" "168.8" "153.9" "182.7" "183.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7097092162087690863" "False" "High" "IsMasterProtein" "O43683" "Mitotic checkpoint serine/threonine-protein kinase BUB1 OS=Homo sapiens OX=9606 GN=BUB1 PE=1 SV=1" "0.000" "False" "6.085" "2" "2" "2" "2" "1085" "122.3" "6.47" "3.54" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf08311" "699" "ENSG00000169679" "BUB1" "E9PC26; F5GXI5; hsa:699; O43430; O43643; O43683; O60626; Q53QE4" "Cell cycle; ATM signaling in development and disease ; Regulation of sister chromatid separation at the metaphase-anaphase transition" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "9" "0" "1.156" "1.005" "0.984" "1.028" "0.958" "0.902" "0.929" "0.947" "0.987" "335.2" "387.5" "336.9" "329.8" "344.7" "321.0" "302.5" "311.4" "317.4" "330.7" "" "" "" "" "" "" "" "" "" "" "314.1" "320.6" "312.8" "254.9" "293.8" "306.7" "276.4" "276.5" "317.4" "318.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3945672141617060885" "False" "High" "IsMasterProtein" "Q9P2E9" "Ribosome-binding protein 1 OS=Homo sapiens OX=9606 GN=RRBP1 PE=1 SV=5" "0.000" "False" "6.084" "12" "3" "3" "2" "1410" "152.4" "8.60" "6.92" "3" "protein metabolism;other metabolic processes;transport" "other membranes;ER/Golgi;translational apparatus" "other molecular function" "Pf05104" "6238" "ENSG00000125844" "RRBP1" "A0A0A0MRV0; A2A2S6; A6NCN6; hsa:6238; O75300; O75301; Q5W165; Q96SB2; Q9BWP1; Q9H476; Q9P2E9" "Ectoderm differentiation" "Signaling by ALK fusions and activated point mutants" "2" "0" "0.978" "1.123" "1.051" "1.106" "0.961" "0.956" "0.981" "1.011" "1.103" "89.8" "87.8" "100.8" "94.4" "99.3" "86.3" "85.9" "88.0" "90.7" "99.0" "" "" "" "" "" "" "" "" "" "" "84.1" "72.6" "93.6" "73.0" "84.6" "82.4" "78.5" "78.2" "90.7" "95.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2174289831199594781" "False" "High" "IsMasterProtein" "Q2KHR3" "Glutamine and serine-rich protein 1 OS=Homo sapiens OX=9606 GN=QSER1 PE=1 SV=3" "0.000" "False" "6.081" "1" "3" "3" "3" "1735" "189.9" "7.08" "5.87" "3" "" "other cell component" "" "Pf13926" "79832" "" "QSER1" "hsa:79832; Q2KHR3; Q6ZU30; Q6ZUR5" "" "" "0" "0" "1.066" "0.976" "0.975" "1.048" "1.031" "1.103" "0.967" "0.936" "1.123" "182.1" "194.1" "177.7" "177.6" "190.8" "187.7" "200.8" "176.2" "170.5" "204.5" "" "" "" "" "" "" "" "" "" "" "170.6" "160.6" "164.9" "137.3" "162.6" "179.3" "183.5" "156.4" "170.5" "196.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6827410314429019344" "False" "High" "IsMasterProtein" "Q9UM22" "Mammalian ependymin-related protein 1 OS=Homo sapiens OX=9606 GN=EPDR1 PE=1 SV=2" "0.000" "False" "6.080" "10" "2" "2" "2" "224" "25.4" "6.60" "5.09" "2" "cell adhesion;other biological processes" "non-structural extracellular;other cytoplasmic organelle" "other molecular function" "Pf00811" "54749" "ENSG00000086289" "EPDR1" "A8K4C0; C9JYS3; hsa:54749; Q06BL0; Q99M77; Q9UM22" "" "" "0" "0" "0.959" "0.946" "1.047" "1.038" "0.991" "0.888" "0.999" "0.894" "0.953" "283.3" "271.8" "268.1" "296.7" "294.2" "280.7" "251.5" "282.9" "253.4" "270.0" "" "" "" "" "" "" "" "" "" "" "265.5" "224.9" "248.9" "229.4" "250.7" "268.2" "229.8" "251.2" "253.4" "260.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8287217106573217655" "False" "High" "IsMasterProtein" "Q92540" "Nonsense-mediated mRNA decay factor SMG7 OS=Homo sapiens OX=9606 GN=SMG7 PE=1 SV=2" "0.000" "False" "6.065" "2" "2" "2" "2" "1137" "127.2" "8.72" "5.69" "2" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10373, Pf10374" "9887" "ENSG00000116698" "SMG7" "B4DRB2; E9PCI0; E9PEH2; hsa:9887; Q5T1Q0; Q6PIE0; Q7Z7H9; Q8IXC1; Q8IXC2; Q92540" "" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "1" "0" "1.083" "0.980" "1.079" "1.005" "1.043" "1.039" "0.838" "0.975" "1.047" "254.9" "276.1" "249.7" "275.1" "256.1" "265.7" "264.9" "213.4" "248.6" "267.0" "" "" "" "" "" "" "" "" "" "" "238.8" "228.5" "231.8" "212.6" "218.3" "253.9" "242.1" "189.5" "248.6" "257.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1867390860608568122" "False" "High" "IsMasterProtein" "Q9BRJ2" "Large ribosomal subunit protein mL45 OS=Homo sapiens OX=9606 GN=MRPL45 PE=1 SV=2" "0.000" "False" "6.056" "8" "3" "5" "3" "306" "35.3" "9.03" "9.03" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf04280" "" "ENSG00000277936" "MRPL45" "A1L436; Q6ZMJ5; Q9BRJ2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.071" "1.018" "1.086" "1.066" "1.057" "1.042" "1.020" "0.981" "1.040" "530.1" "567.7" "539.6" "575.8" "565.2" "560.2" "552.4" "540.8" "519.9" "551.4" "" "" "" "" "" "" "" "" "" "" "496.7" "469.8" "500.9" "445.1" "481.8" "535.2" "504.8" "480.2" "519.9" "530.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1438891196455375570" "False" "High" "IsMasterProtein" "A9UHW6" "MIF4G domain-containing protein OS=Homo sapiens OX=9606 GN=MIF4GD PE=1 SV=1" "0.000" "False" "6.039" "11" "3" "3" "3" "222" "25.4" "5.33" "8.85" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02854" "57409" "ENSG00000125457" "MIF4GD" "A9UHW6; B4DUM7; hsa:57409; Q8N4Q5; Q9HBL5" "" "" "0" "0" "0.929" "0.978" "1.138" "1.008" "1.050" "1.121" "0.942" "1.035" "0.978" "119.1" "110.6" "116.4" "135.5" "120.0" "125.0" "133.5" "112.1" "123.3" "116.4" "" "" "" "" "" "" "" "" "" "" "111.6" "91.6" "108.1" "104.7" "102.3" "119.4" "122.0" "99.6" "123.3" "112.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9153157307515931541" "False" "High" "IsMasterProtein" "Q9UBI9" "Headcase protein homolog OS=Homo sapiens OX=9606 GN=HECA PE=1 SV=1" "0.000" "False" "6.032" "3" "2" "2" "2" "543" "58.8" "8.54" "6.05" "2" "developmental processes;other biological processes" "nucleus;other cell component" "" "Pf15353, Pf16002" "51696" "ENSG00000112406" "HECA" "hsa:51696; Q9UBI9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7698628990297234698" "False" "High" "IsMasterProtein" "Q9Y3D3" "Small ribosomal subunit protein bS16m OS=Homo sapiens OX=9606 GN=MRPS16 PE=1 SV=1" "0.000" "False" "6.026" "12" "2" "2" "2" "137" "15.3" "9.50" "6.83" "2" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "other molecular function" "Pf00886" "51021" "ENSG00000182180" "MRPS16" "B4E032; hsa:51021; Q96Q60; Q9Y3D3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.023" "1.004" "0.886" "0.946" "1.008" "0.896" "0.875" "0.891" "1.022" "837.3" "856.3" "840.7" "742.0" "792.3" "843.9" "750.0" "732.8" "745.7" "855.5" "" "" "" "" "" "" "" "" "" "" "784.5" "708.6" "780.5" "573.6" "675.4" "806.3" "685.3" "650.6" "745.7" "823.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1923018383904393967" "False" "High" "IsMasterProtein" "Q8TAP6" "Centrosomal protein of 76 kDa OS=Homo sapiens OX=9606 GN=CEP76 PE=1 SV=1" "0.000" "False" "6.020" "3" "2" "2" "2" "659" "74.4" "6.74" "5.64" "2" "other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf15627" "79959" "ENSG00000101624" "CEP76" "B0YJB2; B4DXG5; B4DZW1; hsa:79959; Q658N5; Q8TAP6; Q9H9U7" "Genes related to primary cilium development (based on CRISPR)" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "8" "0" "1.068" "1.078" "1.122" "1.200" "1.145" "1.023" "1.069" "1.042" "0.984" "186.0" "198.7" "200.5" "208.7" "223.2" "212.9" "190.2" "198.9" "193.7" "182.9" "" "" "" "" "" "" "" "" "" "" "174.3" "164.4" "186.2" "161.3" "190.2" "203.4" "173.8" "176.6" "193.7" "176.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6309414575858280989" "False" "High" "IsMasterProtein" "Q9GZQ3" "COMM domain-containing protein 5 OS=Homo sapiens OX=9606 GN=COMMD5 PE=1 SV=1" "0.000" "False" "6.017" "10" "3" "4" "3" "224" "24.7" "7.02" "9.89" "3" "" "cytosol;nucleus" "" "Pf07258, Pf21672" "28991" "ENSG00000170619" "COMMD5" "D3DWN7; hsa:28991; Q9GZQ3; Q9NVN6; Q9UHX5" "" "Neddylation" "1" "0" "0.963" "0.936" "0.999" "0.886" "0.956" "0.906" "0.965" "0.987" "1.002" "358.9" "345.7" "335.8" "358.5" "318.1" "343.1" "325.0" "346.3" "354.4" "359.5" "" "" "" "" "" "" "" "" "" "" "336.3" "286.1" "311.8" "277.1" "271.2" "327.8" "297.0" "307.5" "354.4" "346.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5260823146616738925" "False" "High" "IsMasterProtein" "O43829" "Zinc finger and BTB domain-containing protein 14 OS=Homo sapiens OX=9606 GN=ZBTB14 PE=1 SV=2" "0.000" "False" "6.011" "5" "3" "3" "3" "449" "50.9" "6.04" "8.57" "3" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "7541" "ENSG00000198081" "ZBTB14" "hsa:7541; O00403; O43829; Q2TB80" "" "" "0" "0" "1.102" "0.862" "0.906" "0.920" "0.909" "1.026" "0.936" "0.923" "1.009" "191.7" "211.3" "165.2" "173.8" "176.4" "174.3" "196.8" "179.5" "177.1" "193.5" "" "" "" "" "" "" "" "" "" "" "179.7" "174.8" "153.4" "134.3" "150.3" "166.5" "179.8" "159.4" "177.1" "186.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3372054881013806202" "False" "High" "IsMasterProtein" "Q9NVZ3" "Adaptin ear-binding coat-associated protein 2 OS=Homo sapiens OX=9606 GN=NECAP2 PE=1 SV=1" "0.000" "False" "6.008" "7" "2" "3" "2" "263" "28.3" "8.38" "8.54" "2" "transport" "other membranes" "" "Pf07933" "55707" "ENSG00000157191; ENSG00000291380" "NECAP2" "B4DY19; E9PGQ8; hsa:55707; Q5VSU4; Q5VSU5; Q9H7L1; Q9H8L1; Q9NVZ3" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "1.139" "1.017" "1.013" "1.131" "1.037" "1.098" "1.088" "1.000" "1.120" "145.5" "165.7" "148.0" "147.3" "164.6" "150.8" "159.8" "158.3" "145.4" "163.0" "" "" "" "" "" "" "" "" "" "" "136.4" "137.1" "137.4" "113.9" "140.3" "144.1" "146.0" "140.5" "145.4" "156.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4633091577178115671" "False" "High" "IsMasterProtein" "P41212" "Transcription factor ETV6 OS=Homo sapiens OX=9606 GN=ETV6 PE=1 SV=1" "0.000" "False" "5.998" "5" "3" "3" "3" "452" "53.0" "7.43" "8.04" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198" "2120" "ENSG00000139083" "ETV6" "A3QVP6; A8K076; hsa:2120; P41212; Q9UMF6; Q9UMF7; Q9UMG0" "Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Exercise-induced circadian regulation" "Signaling by FLT3 fusion proteins; Signaling by membrane-tethered fusions of PDGFRA or PDGFRB" "4" "0" "1.000" "1.110" "1.081" "1.137" "1.129" "1.076" "1.037" "1.030" "1.061" "194.9" "194.9" "216.4" "210.7" "221.7" "220.1" "209.7" "202.2" "200.8" "206.9" "" "" "" "" "" "" "" "" "" "" "182.7" "161.3" "200.9" "162.9" "188.9" "210.3" "191.6" "179.5" "200.8" "199.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7489520263377738348" "False" "High" "IsMasterProtein" "Q96DI7" "U5 small nuclear ribonucleoprotein 40 kDa protein OS=Homo sapiens OX=9606 GN=SNRNP40 PE=1 SV=1" "0.000" "False" "5.995" "5" "2" "2" "2" "357" "39.3" "8.10" "6.62" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00400" "9410" "ENSG00000060688" "SNRNP40" "B4DQJ1; hsa:9410; O75938; O95320; Q96DI7" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "1.072" "1.072" "1.005" "1.015" "0.923" "1.245" "1.162" "1.156" "1.097" "137.9" "147.9" "147.8" "138.6" "140.0" "127.3" "171.7" "160.3" "159.4" "151.3" "" "" "" "" "" "" "" "" "" "" "129.2" "122.4" "137.2" "107.2" "119.3" "121.6" "156.9" "142.3" "159.4" "145.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "960186512465263261" "False" "High" "IsMasterProtein" "Q96L93" "Kinesin-like protein KIF16B OS=Homo sapiens OX=9606 GN=KIF16B PE=1 SV=2" "0.000" "False" "5.986" "2" "2" "2" "1" "1317" "151.9" "6.16" "6.55" "2" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf00498, Pf00787" "55614" "ENSG00000089177" "KIF16B" "A6NKJ9; A7E2A8; B1AKG3; B1AKT7; C9JDN5; C9JI52; C9JSM8; C9JWJ7; hsa:55614; Q2TBF5; Q5HYC0; Q5HYK1; Q5JWW3; Q5TFK5; Q86VL9; Q86YS5; Q8IYU0; Q96L93; Q9BQJ8; Q9BQM0; Q9BQM1; Q9BQM5; Q9H5U0; Q9HCI2; Q9NXN9" "" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2011789362582396358" "False" "High" "IsMasterProtein" "Q9NSI8" "SAM domain-containing protein SAMSN-1 OS=Homo sapiens OX=9606 GN=SAMSN1 PE=1 SV=1" "0.000" "False" "5.985" "6" "2" "2" "2" "373" "41.7" "5.43" "5.48" "2" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07647, Pf07653, Pf12485" "64092" "ENSG00000155307" "SAMSN1" "B3KWJ3; F8WAA1; hsa:64092; Q8NFF7; Q9C041; Q9NSI8" "TYROBP causal network in microglia" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8527831482180649662" "False" "High" "IsMasterProtein" "Q8NCE2" "Myotubularin-related protein 14 OS=Homo sapiens OX=9606 GN=MTMR14 PE=1 SV=2" "0.000" "False" "5.982" "3" "2" "2" "2" "650" "72.2" "6.24" "6.28" "2" "other metabolic processes" "cytosol;other cell component" "other molecular function" "" "64419" "ENSG00000163719" "MTMR14" "hsa:64419; Q0JTH5; Q0JU83; Q6PIZ4; Q6QE21; Q86VK9; Q8IYK1; Q8NCE2; Q8TCM7; Q9H6C0" "" "Synthesis of PIPs at the plasma membrane; Macroautophagy" "2" "0" "0.928" "0.872" "1.011" "1.086" "0.931" "0.913" "0.845" "0.879" "0.947" "269.8" "250.3" "235.2" "272.9" "293.1" "251.2" "246.3" "227.9" "237.2" "255.5" "" "" "" "" "" "" "" "" "" "" "252.8" "207.1" "218.4" "211.0" "249.8" "240.0" "225.1" "202.4" "237.2" "246.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2699883784093853229" "False" "High" "IsMasterProtein" "Q8IY47" "Kelch repeat and BTB domain-containing protein 2 OS=Homo sapiens OX=9606 GN=KBTBD2 PE=1 SV=2" "0.000" "False" "5.982" "3" "2" "2" "2" "623" "71.3" "5.62" "4.19" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "" "" "Pf00651, Pf01344, Pf07707" "25948" "ENSG00000170852" "KBTBD2" "A8K9T7; hsa:25948; Q86Y62; Q8IY47; Q9P239; Q9UFM7; Q9Y382" "" "" "0" "0" "1.041" "1.014" "1.100" "0.955" "0.985" "1.036" "0.982" "0.923" "1.005" "284.6" "296.2" "288.6" "313.2" "271.8" "280.4" "295.0" "279.5" "262.7" "286.2" "" "" "" "" "" "" "" "" "" "" "266.7" "245.1" "267.9" "242.1" "231.7" "267.9" "269.5" "248.2" "262.7" "275.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8932263568853688601" "False" "High" "IsMasterProtein" "Q9UKA9" "Polypyrimidine tract-binding protein 2 OS=Homo sapiens OX=9606 GN=PTBP2 PE=1 SV=1" "0.000" "False" "5.963" "4" "3" "8" "2" "531" "57.5" "8.66" "18.39" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "58155" "ENSG00000117569" "PTBP2" "hsa:58155; Q8N0Z1; Q8N160; Q8NFB0; Q8NFB1; Q969N9; Q96Q76; Q9UKA9" "Genes targeted by miRNAs in adipocytes; mRNA processing" "" "2" "0" "0.948" "0.961" "0.977" "0.922" "0.904" "0.936" "0.943" "0.891" "0.927" "307.1" "291.0" "295.1" "300.0" "283.2" "277.6" "287.5" "289.6" "273.7" "284.7" "" "" "" "" "" "" "" "" "" "" "287.7" "240.8" "274.0" "231.9" "241.4" "265.3" "262.7" "257.2" "273.7" "274.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4676575217961373957" "False" "High" "IsMasterProtein" "P63098" "Calcineurin subunit B type 1 OS=Homo sapiens OX=9606 GN=PPP3R1 PE=1 SV=2" "0.000" "False" "5.959" "15" "3" "5" "3" "170" "19.3" "4.81" "13.52" "3" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13499" "5534" "ENSG00000221823" "PPP3R1" "B2RC10; B5MDU4; hsa:5534; P06705; P15117; P63098; Q08044; Q53SL0" "Energy metabolism; Transcription factors regulate miRNAs related to cardiac hypertrophy; Alzheimer's disease and miRNA effects; Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; Wnt signaling; Vitamin D in inflammatory diseases; Regucalcin in proximal tubule epithelial kidney cells; Alzheimer's disease" "FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; DARPP-32 events; Activation of BAD and translocation to mitochondria" "15" "0" "1.030" "0.906" "0.890" "0.942" "0.985" "0.998" "1.007" "0.894" "0.943" "556.9" "573.4" "504.7" "495.6" "524.9" "548.7" "555.9" "561.1" "497.8" "525.3" "" "" "" "" "" "" "" "" "" "" "521.8" "474.5" "468.5" "383.1" "447.4" "524.2" "507.9" "498.2" "497.8" "505.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8887953044378161653" "False" "High" "IsMasterProtein" "Q9UPR0" "Inactive phospholipase C-like protein 2 OS=Homo sapiens OX=9606 GN=PLCL2 PE=1 SV=2" "0.000" "False" "5.959" "2" "2" "2" "2" "1127" "125.8" "6.90" "7.74" "2" "cell-cell signaling;cell cycle OR cell proliferation;other metabolic processes;signal transduction;other biological processes" "other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00168, Pf00387, Pf00388, Pf09279, Pf16457" "23228" "ENSG00000154822; ENSG00000284017" "PLCL2" "A8K5V4; hsa:23228; Q8N498; Q9H8L0; Q9UFP9; Q9UPR0" "" "" "0" "0" "0.969" "0.889" "0.981" "0.931" "0.873" "1.038" "0.904" "0.921" "1.027" "137.3" "133.0" "122.1" "134.7" "127.8" "119.9" "142.6" "124.2" "126.4" "141.0" "" "" "" "" "" "" "" "" "" "" "128.6" "110.0" "113.3" "104.1" "108.9" "114.5" "130.3" "110.2" "126.4" "135.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6571071577836756123" "False" "High" "IsMasterProtein" "Q9NUP1" "Biogenesis of lysosome-related organelles complex 1 subunit 4 OS=Homo sapiens OX=9606 GN=BLOC1S4 PE=1 SV=1" "0.000" "False" "5.959" "11" "2" "2" "2" "217" "23.3" "4.98" "6.30" "2" "cell adhesion;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "cytosol;other cell component" "" "" "55330" "ENSG00000186222" "BLOC1S4" "hsa:55330; Q6NVY6; Q96G84; Q9NUP1" "Alstrom syndrome" "Golgi Associated Vesicle Biogenesis" "2" "0" "0.873" "0.909" "0.964" "0.982" "0.997" "0.872" "0.868" "0.910" "0.877" "109.6" "95.7" "99.6" "105.7" "107.7" "109.2" "95.6" "95.2" "99.7" "96.1" "" "" "" "" "" "" "" "" "" "" "102.7" "79.2" "92.5" "81.7" "91.8" "104.4" "87.3" "84.5" "99.7" "92.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3563159699507819169" "False" "High" "IsMasterProtein" "P06280" "Alpha-galactosidase A OS=Homo sapiens OX=9606 GN=GLA PE=1 SV=1" "0.000" "False" "5.947" "6" "3" "4" "3" "429" "48.7" "5.60" "10.83" "3" "other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf16499, Pf17450" "2717" "ENSG00000102393" "GLA" "hsa:2717; P06280; Q6LER7" "Degradation pathway of sphingolipids, including diseases; Ciliary landscape" "Neutrophil degranulation; Glycosphingolipid catabolism" "4" "0" "1.000" "0.986" "1.017" "1.054" "1.033" "0.985" "1.012" "0.957" "0.980" "419.7" "419.7" "413.8" "426.7" "442.4" "433.7" "413.3" "424.6" "401.7" "411.1" "" "" "" "" "" "" "" "" "" "" "393.3" "347.3" "384.2" "329.9" "377.1" "414.4" "377.6" "377.0" "401.7" "395.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1635055545262344476" "False" "High" "IsMasterProtein" "Q9UER7" "Death domain-associated protein 6 OS=Homo sapiens OX=9606 GN=DAXX PE=1 SV=2" "0.000" "False" "5.946" "4" "2" "2" "2" "740" "81.3" "4.87" "7.62" "2" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03344, Pf20920" "1616" "ENSG00000204209; ENSG00000206206; ENSG00000206279; ENSG00000227046; ENSG00000231617" "DAXX" "B4E1I3; F5ANJ6; F5ANJ7; F5H082; hsa:1616; O14747; O15141; O15208; Q5STK9; Q9BWI3; Q9UER7" "Androgen receptor signaling pathway; Amyotrophic lateral sclerosis (ALS); Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; p38 MAPK signaling pathway" "SUMOylation of transcription cofactors; HCMV Early Events; Inhibition of DNA recombination at telomere; Regulation of TP53 Degradation; Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations; Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations" "11" "0" "2.305" "1.166" "1.527" "1.550" "1.723" "1.583" "1.184" "1.477" "1.410" "36.3" "83.6" "42.3" "55.4" "56.3" "62.5" "57.5" "43.0" "53.6" "51.2" "" "" "" "" "" "" "" "" "" "" "34.0" "69.2" "39.3" "42.8" "47.9" "59.7" "52.5" "38.1" "53.6" "49.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6765720071674471585" "False" "High" "IsMasterProtein" "Q15633" "RISC-loading complex subunit TARBP2 OS=Homo sapiens OX=9606 GN=TARBP2 PE=1 SV=3" "0.000" "False" "5.940" "7" "3" "3" "3" "366" "39.0" "6.54" "7.44" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035" "6895" "ENSG00000139546" "TARBP2" "hsa:6895; Q12878; Q15633; Q8WY32; Q8WY33; Q9BRY2" "Fragile X syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "PKR-mediated signaling; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis" "6" "0" "0.982" "1.052" "1.300" "1.023" "1.124" "1.185" "0.955" "0.895" "1.033" "81.7" "80.1" "85.9" "106.2" "83.5" "91.8" "96.7" "78.0" "73.1" "84.4" "" "" "" "" "" "" "" "" "" "" "76.5" "66.3" "79.7" "82.1" "71.2" "87.7" "88.4" "69.3" "73.1" "81.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3341461915485741514" "False" "High" "IsMasterProtein" "Q9HC36" "rRNA methyltransferase 3, mitochondrial OS=Homo sapiens OX=9606 GN=MRM3 PE=1 SV=2" "0.000" "False" "5.938" "5" "2" "2" "2" "420" "47.0" "8.73" "7.80" "2" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00588" "55178" "ENSG00000171861" "MRM3" "hsa:55178; Q53GN1; Q86VC3; Q96F76; Q9HC36; Q9NVQ5" "" "rRNA modification in the mitochondrion" "1" "0" "1.027" "0.933" "1.005" "1.189" "1.208" "1.212" "1.129" "1.098" "1.082" "105.6" "108.5" "98.5" "106.1" "125.6" "127.7" "128.1" "119.3" "116.0" "114.3" "" "" "" "" "" "" "" "" "" "" "99.0" "89.8" "91.5" "82.1" "107.0" "122.0" "117.0" "105.9" "116.0" "110.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5475559016249233817" "False" "High" "IsMasterProtein" "Q9NVT9" "Armadillo repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=ARMC1 PE=1 SV=1" "0.000" "False" "5.937" "7" "2" "2" "2" "282" "31.3" "5.74" "5.46" "2" "cell organization and biogenesis" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf00514" "55156" "ENSG00000104442" "ARMC1" "B4E2W7; hsa:55156; Q9H018; Q9H820; Q9NVT9" "" "" "0" "0" "0.953" "0.906" "0.878" "0.930" "0.927" "0.961" "0.967" "0.855" "0.964" "384.8" "366.7" "348.5" "337.7" "357.8" "356.7" "369.8" "372.1" "328.9" "370.8" "" "" "" "" "" "" "" "" "" "" "360.6" "303.5" "323.5" "261.1" "305.0" "340.8" "337.9" "330.4" "328.9" "357.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7191429951444630095" "False" "High" "IsMasterProtein" "Q96RR4" "Calcium/calmodulin-dependent protein kinase kinase 2 OS=Homo sapiens OX=9606 GN=CAMKK2 PE=1 SV=2" "0.000" "False" "5.931" "6" "2" "2" "2" "588" "64.7" "6.68" "5.53" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "10645" "ENSG00000110931" "CAMKK2" "A8K7Q7; hsa:10645; O94883; Q8IUG2; Q8IUG3; Q8N3I4; Q8WY03; Q8WY04; Q8WY05; Q8WY06; Q96RP1; Q96RP2; Q96RR3; Q96RR4; Q9BWE9; Q9UER3; Q9UES2; Q9Y5N2" "AMP-activated protein kinase signaling; VEGFA-VEGFR2 signaling; CAMKK2 pathway; Neuroinflammation and glutamatergic signaling; Orexin receptor pathway; Hippocampal synaptogenesis and neurogenesis" "Activation of AMPK downstream of NMDARs; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde; Activation of RAC1 downstream of NMDARs" "10" "0" "0.829" "0.695" "1.165" "1.005" "0.877" "0.990" "0.870" "0.910" "1.015" "33.9" "28.1" "23.5" "39.4" "34.0" "29.7" "33.5" "29.4" "30.8" "34.4" "" "" "" "" "" "" "" "" "" "" "31.7" "23.2" "21.9" "30.5" "29.0" "28.4" "30.6" "26.1" "30.8" "33.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5402441647647125323" "False" "High" "IsMasterProtein" "O75880" "Protein SCO1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=SCO1 PE=1 SV=1" "0.000" "False" "5.927" "5" "2" "3" "2" "301" "33.8" "8.88" "9.39" "2" "cell organization and biogenesis;other biological processes" "other membranes;cytoskeleton;mitochondrion" "other molecular function" "Pf02630" "6341" "ENSG00000133028" "SCO1" "B2RDM0; hsa:6341; O75880" "Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "5" "0" "0.930" "1.044" "0.998" "1.114" "1.202" "1.046" "1.171" "1.089" "1.066" "468.6" "436.0" "489.2" "467.4" "521.9" "563.2" "490.0" "548.5" "510.1" "499.7" "" "" "" "" "" "" "" "" "" "" "439.1" "360.8" "454.1" "361.3" "444.9" "538.1" "447.8" "487.0" "510.1" "481.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4261899160220204292" "False" "High" "IsMasterProtein" "Q9ULE0" "Protein WWC3 OS=Homo sapiens OX=9606 GN=WWC3 PE=1 SV=4" "0.000" "False" "5.926" "1" "2" "3" "1" "1216" "136.6" "6.42" "10.28" "2" "other biological processes" "cytosol;other cell component" "other molecular function" "Pf00397" "55841" "ENSG00000047644" "WWC3" "A8KA96; hsa:55841; Q659C1; Q9BTQ1; Q9ULE0; T2C6S4" "" "" "0" "0" "1.117" "1.047" "1.121" "1.086" "1.296" "1.098" "0.932" "1.040" "1.113" "66.7" "74.5" "69.8" "74.8" "72.4" "86.4" "73.2" "62.2" "69.4" "74.2" "" "" "" "" "" "" "" "" "" "" "62.5" "61.6" "64.8" "57.8" "61.7" "82.6" "66.9" "55.2" "69.4" "71.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6940581547763936040" "False" "High" "IsMasterProtein" "Q9NUL3" "Double-stranded RNA-binding protein Staufen homolog 2 OS=Homo sapiens OX=9606 GN=STAU2 PE=1 SV=2" "0.000" "False" "5.916" "4" "2" "2" "1" "570" "62.6" "9.61" "6.14" "2" "stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function" "Pf00035, Pf16482" "27067" "ENSG00000040341" "STAU2" "A0A0A0MTC5; B7Z1I6; B7Z292; B7Z8B4; E7ER74; E9PEI3; E9PF26; E9PF50; hsa:27067; Q6AHY7; Q96HM0; Q96HM1; Q9NUL3; Q9NVI5; Q9UGG6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5620722506811584939" "False" "High" "IsMasterProtein" "Q96GG9" "DCN1-like protein 1 OS=Homo sapiens OX=9606 GN=DCUN1D1 PE=1 SV=1" "0.000" "False" "5.915" "6" "3" "3" "3" "259" "30.1" "5.34" "8.61" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03556, Pf14555" "54165" "ENSG00000043093" "DCUN1D1" "B2RB37; hsa:54165; Q7L3G9; Q8TEX7; Q96GG9; Q9H6M1; Q9HCT3" "" "Neddylation" "1" "0" "0.986" "1.077" "0.884" "0.948" "0.976" "0.913" "0.988" "0.974" "0.964" "604.4" "595.8" "651.2" "534.3" "573.2" "589.6" "552.0" "597.0" "588.6" "582.9" "" "" "" "" "" "" "" "" "" "" "566.3" "493.0" "604.5" "413.0" "488.6" "563.3" "504.4" "530.1" "588.6" "561.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7220611050320335909" "False" "High" "IsMasterProtein" "Q8TDH9" "Biogenesis of lysosome-related organelles complex 1 subunit 5 OS=Homo sapiens OX=9606 GN=BLOC1S5 PE=1 SV=1" "0.000" "False" "5.912" "9" "2" "2" "2" "187" "21.6" "7.59" "6.60" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "ER/Golgi;other cell component" "" "Pf14942" "63915" "ENSG00000188428" "BLOC1S5" "B4DVM2; hsa:63915; Q0VDJ6; Q0VDJ7; Q5THS1; Q68D56; Q8N5F9; Q8TDH9; Q9NU16" "" "" "0" "0" "1.079" "1.003" "0.948" "0.964" "0.947" "0.949" "0.983" "0.986" "0.953" "290.0" "312.9" "290.9" "274.9" "279.6" "274.6" "275.1" "285.1" "285.8" "276.2" "" "" "" "" "" "" "" "" "" "" "271.7" "258.9" "270.1" "212.5" "238.3" "262.4" "251.3" "253.2" "285.8" "266.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8811809090486028216" "False" "High" "IsMasterProtein" "Q6QNY0" "Biogenesis of lysosome-related organelles complex 1 subunit 3 OS=Homo sapiens OX=9606 GN=BLOC1S3 PE=1 SV=1" "0.000" "False" "5.905" "12" "3" "3" "3" "202" "21.2" "5.15" "8.53" "3" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "cytosol;ER/Golgi;other cell component" "transporter activity" "Pf15753" "388552" "ENSG00000189114" "BLOC1S3" "B2RXB8; hsa:388552; Q6QNY0" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "1.030" "0.942" "1.041" "1.026" "1.101" "0.987" "0.955" "0.995" "0.989" "601.4" "619.6" "566.4" "625.8" "617.0" "662.3" "593.5" "574.2" "598.2" "595.1" "" "" "" "" "" "" "" "" "" "" "563.5" "512.7" "525.9" "483.8" "526.0" "632.8" "542.3" "509.8" "598.2" "573.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6257643935121491465" "False" "High" "IsMasterProtein" "Q15120" "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial OS=Homo sapiens OX=9606 GN=PDK3 PE=1 SV=1" "0.000" "False" "5.902" "5" "2" "2" "2" "406" "46.9" "8.37" "5.60" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "mitochondrion;nucleus" "kinase activity;other molecular function" "Pf02518, Pf10436" "5165" "ENSG00000067992" "PDK3" "B4DXG6; hsa:5165; Q15120" "" "Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "2" "0" "1.046" "1.047" "1.043" "1.037" "1.021" "0.942" "0.953" "0.992" "1.063" "353.2" "369.3" "369.7" "368.3" "366.3" "360.7" "332.7" "336.7" "350.4" "375.3" "" "" "" "" "" "" "" "" "" "" "330.9" "305.6" "343.2" "284.7" "312.2" "344.6" "304.0" "299.0" "350.4" "361.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5091177938667012153" "False" "High" "IsMasterProtein" "P41743" "Protein kinase C iota type OS=Homo sapiens OX=9606 GN=PRKCI PE=1 SV=2" "0.000" "False" "5.902" "4" "2" "3" "2" "596" "68.2" "5.85" "9.95" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf00433, Pf00564" "5584" "ENSG00000163558" "PRKCI" "D3DNQ4; hsa:5584; P41743; Q8WW06" "Glioblastoma signaling pathways; Corticotropin-releasing hormone signaling pathway; G protein signaling pathways; VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Osteoblast differentiation and related diseases; Insulin signaling; Complement system in neuronal development and plasticity; Chronic hyperglycemia impairment of neuron function" "KEAP1-NFE2L2 pathway; Tight junction interactions; Pre-NOTCH Transcription and Translation; p75NTR recruits signalling complexes" "15" "0" "0.954" "1.036" "1.166" "1.103" "0.974" "0.970" "0.896" "0.892" "0.919" "207.6" "198.1" "215.1" "242.0" "228.9" "202.2" "201.3" "185.9" "185.2" "190.7" "" "" "" "" "" "" "" "" "" "" "194.5" "163.9" "199.7" "187.1" "195.1" "193.2" "183.9" "165.0" "185.2" "183.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6795582567929622559" "False" "High" "IsMasterProtein" "P61916" "NPC intracellular cholesterol transporter 2 OS=Homo sapiens OX=9606 GN=NPC2 PE=1 SV=1" "0.000" "False" "5.901" "11" "2" "4" "2" "151" "16.6" "7.65" "13.09" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf02221" "10577" "ENSG00000119655" "NPC2" "B4DQV7; P61916; Q15668; Q29413" "TYROBP causal network in microglia; Degradation pathway of sphingolipids, including diseases; Ebola virus infection in host; Cholesterol metabolism; Fatty acids and lipoproteins transport in hepatocytes" "Neutrophil degranulation; LDL clearance" "7" "0" "1.044" "0.960" "0.925" "0.996" "1.002" "0.915" "1.000" "0.927" "1.032" "639.6" "667.7" "614.2" "591.6" "637.4" "640.8" "585.0" "639.6" "593.2" "659.8" "" "" "" "" "" "" "" "" "" "" "599.3" "552.5" "570.2" "457.4" "543.3" "612.3" "534.6" "567.9" "593.2" "635.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8399686422006739058" "False" "High" "IsMasterProtein" "O15116" "U6 snRNA-associated Sm-like protein LSm1 OS=Homo sapiens OX=9606 GN=LSM1 PE=1 SV=1" "0.000" "False" "5.889" "20" "2" "2" "2" "133" "15.2" "5.22" "7.77" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "27257" "ENSG00000175324" "LSM1" "B2R5E6; hsa:27257; O15116" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "1.218" "1.085" "1.089" "1.171" "1.367" "1.105" "1.219" "1.066" "1.189" "21.8" "26.5" "23.6" "23.7" "25.5" "29.8" "24.1" "26.6" "23.2" "25.9" "" "" "" "" "" "" "" "" "" "" "20.4" "22.0" "21.9" "18.3" "21.7" "28.4" "22.0" "23.6" "23.2" "24.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8783162572127248995" "False" "High" "IsMasterProtein" "Q9H4A5" "Golgi phosphoprotein 3-like OS=Homo sapiens OX=9606 GN=GOLPH3L PE=1 SV=1" "0.000" "False" "5.888" "8" "3" "3" "3" "285" "32.7" "5.83" "7.81" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf05719" "55204" "ENSG00000143457" "GOLPH3L" "B1AN09; B7Z6N3; hsa:55204; Q9H4A5; Q9NVK0" "" "" "0" "0" "1.027" "1.007" "0.970" "0.932" "1.018" "1.012" "1.023" "0.870" "0.949" "208.6" "214.2" "210.1" "202.3" "194.4" "212.3" "211.0" "213.3" "181.5" "198.0" "" "" "" "" "" "" "" "" "" "" "195.4" "177.3" "195.0" "156.4" "165.7" "202.9" "192.8" "189.4" "181.5" "190.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6077742637667714135" "False" "High" "IsMasterProtein" "Q00535" "Cyclin-dependent kinase 5 OS=Homo sapiens OX=9606 GN=CDK5 PE=1 SV=3" "0.000" "False" "5.887" "6" "2" "3" "1" "292" "33.3" "7.66" "9.55" "2" "cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "1020" "ENSG00000164885" "CDK5" "A1XKG3; hsa:1020; Q00535" "miRNA regulation of DNA damage response; Nicotine effect on dopaminergic neurons; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling in development and disease ; Alzheimer's disease; Neurogenesis regulation in the olfactory epithelium; DNA damage response" "NPAS4 regulates expression of target genes; NGF-stimulated transcription; Regulation of TP53 Activity through Phosphorylation; Factors involved in megakaryocyte development and platelet production; CRMPs in Sema3A signaling; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; DARPP-32 events; Activated NTRK2 signals through CDK5" "16" "0" "1.050" "1.036" "1.040" "0.987" "0.980" "1.034" "1.015" "1.009" "1.129" "140.1" "147.0" "145.1" "145.7" "138.3" "137.2" "144.8" "142.2" "141.3" "158.1" "" "" "" "" "" "" "" "" "" "" "131.2" "121.7" "134.7" "112.6" "117.9" "131.1" "132.3" "126.3" "141.3" "152.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5438538710980627953" "False" "High" "IsMasterProtein" "Q9H2C0" "Gigaxonin OS=Homo sapiens OX=9606 GN=GAN PE=1 SV=1" "0.000" "False" "5.885" "4" "2" "2" "2" "597" "67.6" "5.85" "2.39" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "" "Pf00651, Pf01344, Pf07707" "8139" "ENSG00000261609" "GAN" "hsa:8139; Q9H2C0" "" "Neddylation; Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "0.889" "0.961" "0.902" "0.922" "0.973" "0.890" "0.950" "0.911" "0.938" "364.6" "324.0" "350.4" "328.8" "336.1" "354.6" "324.4" "346.2" "332.0" "342.0" "" "" "" "" "" "" "" "" "" "" "341.6" "268.1" "325.3" "254.2" "286.4" "338.7" "296.4" "307.4" "332.0" "329.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6209481463683659801" "False" "High" "IsMasterProtein" "Q71F23" "Centromere protein U OS=Homo sapiens OX=9606 GN=CENPU PE=1 SV=1" "0.000" "False" "5.885" "6" "2" "3" "2" "418" "47.5" "9.13" "10.43" "2" "cell cycle OR cell proliferation;developmental processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf13097" "79682" "ENSG00000151725" "CENPU" "A2RRD9; hsa:79682; Q09GN2; Q32Q71; Q71F23; Q9H5G1" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Deposition of new CENPA-containing nucleosomes at the centromere; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "1.015" "1.020" "1.131" "1.143" "1.149" "1.165" "1.110" "1.094" "1.199" "254.4" "258.2" "259.5" "287.6" "290.8" "292.2" "296.3" "282.3" "278.4" "305.1" "" "" "" "" "" "" "" "" "" "" "238.4" "213.6" "241.0" "222.3" "247.9" "279.2" "270.7" "250.7" "278.4" "293.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5856391887248193599" "False" "High" "IsMasterProtein" "Q9H4H8" "Protein FAM83D OS=Homo sapiens OX=9606 GN=FAM83D PE=1 SV=3" "0.000" "False" "5.883" "4" "3" "3" "3" "585" "64.4" "6.54" "7.20" "3" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf07894" "81610" "ENSG00000101447" "FAM83D" "B4E1I7; hsa:81610; Q5THR2; Q68EN1; Q6P457; Q7Z6H0; Q96DF5; Q96N89; Q9BVM8; Q9H4H8" "" "Signaling by EGFR" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3950704505580312253" "False" "High" "IsMasterProtein" "Q9BVI4" "Nucleolar complex protein 4 homolog OS=Homo sapiens OX=9606 GN=NOC4L PE=1 SV=1" "0.000" "False" "5.881" "5" "3" "3" "3" "516" "58.4" "7.49" "8.42" "3" "RNA metabolism OR transcription;other metabolic processes" "other membranes;nucleus;other cell component" "" "Pf03914" "79050" "ENSG00000184967; ENSG00000288146" "NOC4L" "hsa:79050; Q8N2S5; Q96I14; Q9BVI4" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.049" "0.943" "1.187" "1.069" "1.001" "1.164" "1.122" "1.072" "1.092" "369.6" "387.6" "348.4" "438.7" "395.2" "370.0" "430.2" "414.6" "396.2" "403.8" "" "" "" "" "" "" "" "" "" "" "346.3" "320.7" "323.5" "339.1" "336.8" "353.5" "393.1" "368.1" "396.2" "388.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6640986681869860573" "False" "High" "IsMasterProtein" "P40123" "Adenylyl cyclase-associated protein 2 OS=Homo sapiens OX=9606 GN=CAP2 PE=1 SV=1" "0.000" "False" "5.871" "5" "2" "2" "1" "477" "52.8" "6.37" "5.08" "2" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "cytoskeletal activity;other molecular function" "Pf01213, Pf08603" "10486" "ENSG00000112186" "CAP2" "B2R5Y3; B7Z1C4; B7Z214; hsa:10486; P40123; Q6IAY2" "Ectoderm differentiation; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway" "Role of ABL in ROBO-SLIT signaling" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5634766023329637374" "False" "High" "IsMasterProtein" "Q9HAF1" "Chromatin modification-related protein MEAF6 OS=Homo sapiens OX=9606 GN=MEAF6 PE=1 SV=1" "0.000" "False" "5.868" "10" "2" "2" "2" "191" "21.6" "9.32" "7.83" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf09340" "64769" "ENSG00000163875" "MEAF6" "B1AK64; hsa:64769; Q4F967; Q7Z311; Q86WE3; Q9HAF1" "" "HATs acetylate histones; Regulation of TP53 Activity through Acetylation" "2" "0" "1.044" "1.068" "1.076" "1.085" "0.989" "1.099" "1.092" "1.041" "1.017" "464.1" "484.4" "495.7" "499.2" "503.4" "459.0" "510.1" "506.9" "483.0" "471.9" "" "" "" "" "" "" "" "" "" "" "434.8" "400.8" "460.2" "385.9" "429.1" "438.5" "466.1" "450.1" "483.0" "454.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "983128830238586266" "False" "High" "IsMasterProtein" "Q53F19" "Nuclear cap-binding protein subunit 3 OS=Homo sapiens OX=9606 GN=NCBP3 PE=1 SV=2" "0.000" "False" "5.867" "3" "2" "2" "2" "620" "70.5" "5.73" "6.03" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf10309" "55421" "ENSG00000074356" "NCBP3" "B3KWG7; hsa:55421; Q53F19; Q7L406; Q96FK1; Q9NXZ4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6385362476021457625" "False" "High" "IsMasterProtein" "B3KNS4" "Endogenous retrovirus group K3 member 1 OS=Homo sapiens OX=9606 GN=ERVK3-1 PE=1 SV=1" "0.000" "False" "5.853" "26" "2" "2" "2" "109" "11.6" "7.78" "8.14" "2" "" "" "" "Pf15695" "" "ENSG00000142396" "ERVK3-1" "B3KNS4" "" "" "0" "0" "1.256" "1.173" "1.166" "1.004" "0.985" "1.021" "1.044" "0.985" "1.031" "369.4" "464.1" "433.3" "430.6" "370.8" "363.8" "377.2" "385.7" "363.7" "380.8" "" "" "" "" "" "" "" "" "" "" "346.1" "384.0" "402.3" "332.9" "316.1" "347.6" "344.6" "342.5" "363.7" "366.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7585773354798248656" "False" "High" "IsMasterProtein" "O60232" "Protein ZNRD2 OS=Homo sapiens OX=9606 GN=ZNRD2 PE=1 SV=1" "0.000" "False" "5.847" "12" "2" "2" "2" "199" "21.5" "5.24" "7.72" "2" "cell cycle OR cell proliferation;other biological processes" "" "" "Pf06677" "10534" "ENSG00000173465" "ZNRD2" "hsa:10534; O60232" "" "" "0" "0" "1.050" "1.046" "1.104" "1.030" "1.061" "0.969" "1.014" "1.006" "1.068" "395.9" "415.6" "414.2" "437.1" "407.6" "420.1" "383.8" "401.5" "398.1" "422.8" "" "" "" "" "" "" "" "" "" "" "370.9" "343.9" "384.5" "337.9" "347.4" "401.4" "350.7" "356.5" "398.1" "407.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3536014580655726636" "False" "High" "IsMasterProtein" "P98170" "E3 ubiquitin-protein ligase XIAP OS=Homo sapiens OX=9606 GN=XIAP PE=1 SV=2" "0.000" "False" "5.839" "4" "2" "2" "2" "497" "56.6" "6.65" "6.88" "2" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00653, Pf13920, Pf21290" "331" "ENSG00000101966" "XIAP" "D3DTF2; hsa:331; P98170; Q9NQ14" "Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis modulation and signaling; Apoptosis; Focal adhesion; Copper homeostasis; NO/cGMP/PKG mediated neuroprotection; Complement system in neuronal development and plasticity" "Regulation of PTEN stability and activity; Deactivation of the beta-catenin transactivating complex; Regulation of necroptotic cell death; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling; Regulation of PTEN localization" "20" "0" "1.136" "1.016" "1.084" "1.191" "1.067" "0.985" "0.832" "0.979" "1.031" "114.7" "130.3" "116.4" "124.3" "136.6" "122.3" "112.9" "95.3" "112.2" "118.2" "" "" "" "" "" "" "" "" "" "" "107.4" "107.8" "108.1" "96.1" "116.4" "116.9" "103.2" "84.7" "112.2" "113.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4502838028789951010" "False" "High" "IsMasterProtein" "P51397" "Death-associated protein 1 OS=Homo sapiens OX=9606 GN=DAP PE=1 SV=3" "0.000" "False" "5.836" "16" "2" "2" "2" "102" "11.2" "9.32" "5.29" "2" "other metabolic processes;stress response;signal transduction;other biological processes" "" "other molecular function" "Pf15228" "1611" "ENSG00000112977" "DAP" "hsa:1611; P51397; Q6FGC3; Q9BUC9" "" "" "0" "0" "1.169" "1.122" "1.129" "1.199" "1.234" "1.171" "1.165" "1.297" "1.095" "43.8" "51.2" "49.1" "49.4" "52.5" "54.0" "51.3" "51.0" "56.8" "47.9" "" "" "" "" "" "" "" "" "" "" "41.0" "42.3" "45.6" "38.2" "44.7" "51.6" "46.8" "45.3" "56.8" "46.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-749856808040687854" "False" "High" "IsMasterProtein" "Q8WTS6" "Histone-lysine N-methyltransferase SETD7 OS=Homo sapiens OX=9606 GN=SETD7 PE=1 SV=1" "0.000" "False" "5.819" "5" "2" "4" "2" "366" "40.7" "4.63" "9.27" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00856, Pf02493" "80854" "ENSG00000145391" "SETD7" "B5WWL3; hsa:80854; Q0VAH3; Q4W5A9; Q8WTS6; Q9C0E6" "Histone modifications" "PKMTs methylate histone lysines" "2" "0" "0.976" "0.973" "0.867" "0.895" "0.931" "0.869" "0.933" "0.948" "0.918" "569.6" "555.8" "554.1" "494.1" "509.8" "530.3" "495.1" "531.7" "540.1" "522.8" "" "" "" "" "" "" "" "" "" "" "533.7" "459.9" "514.4" "382.0" "434.6" "506.7" "452.4" "472.1" "540.1" "503.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1272084248319891202" "False" "High" "IsMasterProtein" "Q9UKB1" "F-box/WD repeat-containing protein 11 OS=Homo sapiens OX=9606 GN=FBXW11 PE=1 SV=1" "0.000" "False" "5.810" "4" "2" "2" "2" "542" "62.1" "7.12" "4.89" "2" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf12125, Pf12937" "23291" "ENSG00000072803" "FBXW11" "B2RC98; hsa:23291; Q9P2S8; Q9P2S9; Q9UKB1; Q9Y4C6" "TNF-alpha signaling pathway; VEGFA-VEGFR2 signaling" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Regulation of PLK1 Activity at G2/M Transition; MAP3K8 (TPL2)-dependent MAPK1/3 activation" "12" "0" "1.054" "1.063" "1.072" "0.971" "0.956" "1.098" "0.940" "0.911" "0.990" "221.1" "233.1" "235.0" "237.1" "214.8" "211.5" "242.8" "207.8" "201.6" "218.8" "" "" "" "" "" "" "" "" "" "" "207.2" "192.9" "218.2" "183.3" "183.1" "202.1" "221.8" "184.5" "201.6" "210.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-708383096801431027" "False" "High" "IsMasterProtein" "Q9HD34" "LYR motif-containing protein 4 OS=Homo sapiens OX=9606 GN=LYRM4 PE=1 SV=1" "0.000" "False" "5.809" "21" "2" "3" "2" "91" "10.8" "10.73" "9.42" "2" "cell organization and biogenesis" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf05347" "57128" "ENSG00000214113" "LYRM4" "A8K543; hsa:57128; Q5XKP1; Q9HD34" "Iron-sulfur cluster biogenesis" "Mitochondrial iron-sulfur cluster biogenesis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3281625266906913156" "False" "High" "IsMasterProtein" "Q7RTP6" "[F-actin]-monooxygenase MICAL3 OS=Homo sapiens OX=9606 GN=MICAL3 PE=1 SV=2" "0.000" "False" "5.797" "1" "2" "2" "2" "2002" "224.2" "5.55" "7.42" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00412, Pf01494, Pf12130" "57553" "ENSG00000243156" "MICAL3" "B2RXJ5; E9PEF0; O94909; Q5U4P4; Q6ICK4; Q7RTP6; Q96DF2; Q9P2I3" "" "" "0" "0" "1.048" "0.964" "1.118" "1.133" "0.976" "1.037" "0.897" "0.979" "0.967" "489.0" "512.7" "471.3" "546.9" "553.9" "477.1" "507.0" "438.6" "478.5" "472.9" "" "" "" "" "" "" "" "" "" "" "458.2" "424.2" "437.5" "422.8" "472.1" "455.8" "463.2" "389.4" "478.5" "455.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1549161421235899806" "False" "High" "IsMasterProtein" "Q96EH3" "Mitochondrial assembly of ribosomal large subunit protein 1 OS=Homo sapiens OX=9606 GN=MALSU1 PE=1 SV=1" "0.000" "False" "5.794" "12" "2" "4" "2" "234" "26.2" "5.49" "13.46" "2" "other biological processes" "cytosol;mitochondrion" "translation activity" "Pf02410" "115416" "ENSG00000156928" "MALSU1" "A4D154; hsa:115416; Q96EH3" "" "" "0" "0" "0.991" "1.086" "0.957" "1.049" "1.045" "1.021" "1.067" "1.022" "1.036" "736.6" "729.9" "799.7" "704.8" "772.7" "770.0" "752.4" "786.0" "752.6" "763.0" "" "" "" "" "" "" "" "" "" "" "690.2" "604.0" "742.4" "544.8" "658.7" "735.7" "687.5" "697.9" "752.6" "734.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-662349959999439869" "False" "High" "IsMasterProtein" "Q92871" "Phosphomannomutase 1 OS=Homo sapiens OX=9606 GN=PMM1 PE=1 SV=2" "0.000" "False" "5.783" "10" "3" "3" "2" "262" "29.7" "5.74" "7.78" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf03332" "5372" "ENSG00000100417" "PMM1" "A8K003; hsa:5372; Q92586; Q92871" "" "Synthesis of GDP-mannose" "1" "0" "0.980" "1.052" "1.150" "1.084" "1.016" "0.999" "1.025" "1.055" "1.014" "351.0" "344.2" "369.2" "403.7" "380.6" "356.7" "350.7" "359.7" "370.4" "356.0" "" "" "" "" "" "" "" "" "" "" "328.9" "284.8" "342.8" "312.1" "324.4" "340.8" "320.5" "319.4" "370.4" "342.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5517326746891322777" "False" "High" "IsMasterProtein" "Q9H2P0" "Activity-dependent neuroprotector homeobox protein OS=Homo sapiens OX=9606 GN=ADNP PE=1 SV=1" "0.000" "False" "5.769" "2" "2" "2" "2" "1102" "123.5" "7.34" "5.81" "2" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00046, Pf19627" "23394" "ENSG00000101126" "ADNP" "E1P5Y2; hsa:23394; O94881; Q5BKU2; Q9H2P0; Q9UG34" "" "" "0" "0" "1.300" "1.066" "1.080" "1.316" "1.108" "1.380" "1.573" "1.345" "1.399" "53.3" "69.3" "56.8" "57.6" "70.2" "59.0" "73.5" "83.8" "71.7" "74.6" "" "" "" "" "" "" "" "" "" "" "49.9" "57.3" "52.7" "44.5" "59.8" "56.4" "67.2" "74.4" "71.7" "71.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8568464795180105445" "False" "High" "IsMasterProtein" "Q9Y385" "Ubiquitin-conjugating enzyme E2 J1 OS=Homo sapiens OX=9606 GN=UBE2J1 PE=1 SV=2" "0.000" "False" "5.767" "6" "2" "2" "2" "318" "35.2" "6.74" "6.24" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf00179" "51465" "ENSG00000198833" "UBE2J1" "A8K3F9; hsa:51465; Q53F25; Q5W0N4; Q9BZ32; Q9NQL3; Q9NY66; Q9P011; Q9P0S0; Q9UF10; Q9Y385" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "Antigen processing: Ubiquitination & Proteasome degradation" "3" "0" "0.954" "1.031" "0.961" "0.973" "1.009" "1.047" "1.042" "1.031" "0.996" "306.1" "292.2" "315.7" "294.3" "298.0" "308.8" "320.5" "318.9" "315.8" "304.8" "" "" "" "" "" "" "" "" "" "" "286.9" "241.8" "293.1" "227.5" "254.0" "295.0" "292.9" "283.1" "315.8" "293.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-580559568770530829" "False" "High" "IsMasterProtein" "Q14135" "Transcription cofactor vestigial-like protein 4 OS=Homo sapiens OX=9606 GN=VGLL4 PE=1 SV=4" "0.000" "False" "5.766" "7" "2" "2" "2" "290" "30.9" "8.22" "7.13" "2" "other biological processes" "nucleus" "other molecular function" "Pf15245" "9686" "ENSG00000144560" "VGLL4" "B4DTS7; hsa:9686; J3KN68; Q14135; Q7L5V0; Q9BQ78" "Hippo-Merlin signaling dysregulation; Pleural mesothelioma" "" "2" "0" "0.997" "1.018" "0.911" "0.923" "0.937" "0.836" "0.903" "0.905" "0.923" "333.6" "332.7" "339.7" "303.8" "307.8" "312.6" "278.8" "301.3" "301.8" "307.8" "" "" "" "" "" "" "" "" "" "" "312.6" "275.3" "315.3" "234.9" "262.4" "298.6" "254.7" "267.5" "301.8" "296.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7086888772498369272" "False" "High" "IsMasterProtein" "Q15596" "Nuclear receptor coactivator 2 OS=Homo sapiens OX=9606 GN=NCOA2 PE=1 SV=2" "0.000" "False" "5.759" "1" "2" "2" "2" "1464" "159.1" "6.64" "6.43" "2" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00989, Pf07469, Pf08815, Pf08832, Pf14598, Pf16279, Pf16665" "10499" "ENSG00000140396" "NCOA2" "hsa:10499; Q14CD2; Q15596" "Androgen receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway" "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Endogenous sterols; Heme signaling; SUMOylation of transcription cofactors; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Estrogen-dependent gene expression; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); HATs acetylate histones; Recycling of bile acids and salts; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; RORA activates gene expression" "25" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9151780766463194199" "False" "High" "IsMasterProtein" "P24863" "Cyclin-C OS=Homo sapiens OX=9606 GN=CCNC PE=1 SV=2" "0.000" "False" "5.754" "6" "2" "2" "2" "283" "33.2" "7.33" "7.13" "2" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00134, Pf16899" "892" "ENSG00000112237" "CCNC" "B4DPZ1; hsa:892; P24863; Q9H543" "Vitamin D receptor pathway" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH1 Intracellular Domain Regulates Transcription" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2771631356277906494" "False" "High" "IsMasterProtein" "Q01650" "Large neutral amino acids transporter small subunit 1 OS=Homo sapiens OX=9606 GN=SLC7A5 PE=1 SV=2" "0.000" "False" "5.744" "3" "2" "2" "2" "507" "55.0" "7.72" "5.66" "2" "stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf13520" "8140" "ENSG00000103257" "SLC7A5" "hsa:8140; Q01650; Q8IV97; Q9UBN8; Q9UP15; Q9UQC0" "Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Pleural mesothelioma" "Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane" "7" "0" "1.043" "0.969" "0.994" "1.029" "1.032" "0.987" "1.021" "0.843" "0.834" "366.0" "381.9" "354.5" "363.7" "376.5" "377.8" "361.1" "373.7" "308.4" "305.3" "" "" "" "" "" "" "" "" "" "" "343.0" "316.0" "329.1" "281.1" "320.9" "360.9" "329.9" "331.8" "308.4" "294.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8013804065466167884" "False" "High" "IsMasterProtein" "Q3B7T1" "Erythroid differentiation-related factor 1 OS=Homo sapiens OX=9606 GN=EDRF1 PE=1 SV=1" "0.000" "False" "5.742" "2" "3" "3" "3" "1238" "138.4" "6.33" "8.54" "3" "other biological processes" "nucleus" "" "" "26098" "ENSG00000107938" "EDRF1" "B2RC65; hsa:26098; Q3B7T1; Q3KR40; Q4G190; Q5VZQ4; Q8IZ74; Q9Y3W4" "" "" "0" "0" "1.092" "1.053" "1.089" "1.052" "1.056" "1.033" "0.928" "1.046" "1.006" "450.8" "492.3" "474.7" "491.1" "474.4" "476.2" "465.5" "418.4" "471.4" "453.3" "" "" "" "" "" "" "" "" "" "" "422.4" "407.4" "440.7" "379.6" "404.4" "455.0" "425.4" "371.5" "471.4" "436.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8397270974056062959" "False" "High" "IsMasterProtein" "Q9NRL3" "Striatin-4 OS=Homo sapiens OX=9606 GN=STRN4 PE=1 SV=2" "0.000" "False" "5.730" "3" "2" "3" "2" "753" "80.5" "5.40" "7.15" "2" "" "other membranes;other cell component" "other molecular function" "Pf00400, Pf08232" "29888" "ENSG00000090372" "STRN4" "A0A024R0V2; B4DQH7; F8VYA6; hsa:29888; Q8NE53; Q9NRL3" "" "" "0" "0" "1.147" "1.069" "1.452" "1.116" "1.146" "1.261" "1.066" "1.002" "1.121" "295.9" "339.3" "316.2" "429.5" "330.3" "339.2" "373.0" "315.5" "296.5" "331.8" "" "" "" "" "" "" "" "" "" "" "277.2" "280.8" "293.6" "332.0" "281.5" "324.1" "340.8" "280.1" "296.5" "319.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2758038755542979545" "False" "High" "IsMasterProtein" "P61769" "Beta-2-microglobulin OS=Homo sapiens OX=9606 GN=B2M PE=1 SV=1" "0.000" "False" "5.718" "17" "2" "2" "2" "119" "13.7" "6.52" "5.99" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07654" "567" "ENSG00000166710; ENSG00000273686" "B2M" "hsa:567; P01884; P61769; Q540F8; Q6IAT8; Q9UCK0; Q9UD48; Q9UDF4" "IL-18 signaling pathway" "ER-Phagosome pathway; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Amyloid fiber formation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; DAP12 signaling; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Modulation by Mtb of host immune system; Nef mediated downregulation of MHC class I complex cell surface expression; Endosomal/Vacuolar pathway" "13" "0" "1.015" "0.997" "1.035" "1.046" "0.983" "1.062" "1.087" "1.053" "1.015" "167.2" "169.7" "166.6" "173.1" "174.9" "164.3" "177.5" "181.7" "176.0" "169.7" "" "" "" "" "" "" "" "" "" "" "156.6" "140.4" "154.7" "133.8" "149.1" "157.0" "162.2" "161.3" "176.0" "163.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2219235455752224995" "False" "High" "IsMasterProtein" "P29558" "RNA-binding motif, single-stranded-interacting protein 1 OS=Homo sapiens OX=9606 GN=RBMS1 PE=1 SV=3" "0.000" "False" "5.714" "5" "2" "2" "2" "406" "44.5" "8.79" "7.23" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "5937" "ENSG00000153250" "RBMS1" "hsa:5937; P29558; Q14869; Q15433; Q53P46; Q53QX8; Q53RG6; Q8WV20" "" "" "0" "0" "1.034" "1.059" "1.074" "1.122" "1.135" "1.104" "1.062" "1.041" "1.140" "166.9" "172.7" "176.9" "179.3" "187.4" "189.5" "184.2" "177.2" "173.8" "190.3" "" "" "" "" "" "" "" "" "" "" "156.4" "142.9" "164.2" "138.6" "159.7" "181.0" "168.3" "157.4" "173.8" "183.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9074819377594512916" "False" "High" "IsMasterProtein" "Q9BQ67" "Glutamate-rich WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GRWD1 PE=1 SV=1" "0.000" "False" "5.703" "4" "2" "4" "2" "446" "49.4" "4.92" "8.56" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "83743" "ENSG00000105447" "GRWD1" "A0MNN5; hsa:83743; Q8TF59; Q9BQ67" "" "" "0" "0" "1.336" "1.085" "1.339" "1.038" "1.040" "1.087" "0.923" "1.036" "0.878" "69.3" "92.6" "75.1" "92.8" "71.9" "72.1" "75.3" "63.9" "71.8" "60.9" "" "" "" "" "" "" "" "" "" "" "64.9" "76.6" "69.8" "71.7" "61.3" "68.9" "68.8" "56.8" "71.8" "58.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7523601130490084284" "False" "High" "IsMasterProtein" "Q9BX63" "Fanconi anemia group J protein OS=Homo sapiens OX=9606 GN=BRIP1 PE=1 SV=2" "0.000" "False" "5.698" "2" "3" "3" "3" "1249" "140.8" "6.92" "8.63" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06733, Pf13307" "83990" "ENSG00000136492" "BRIP1" "A0A024QZ45; hsa:83990; Q3MJE2; Q8NCI5; Q9BX63" "DNA repair pathways, full network" "Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Cytosolic iron-sulfur cluster assembly" "16" "0" "0.929" "0.972" "1.063" "1.010" "0.952" "0.888" "0.866" "0.868" "0.918" "279.0" "259.2" "271.2" "296.5" "281.8" "265.5" "247.8" "241.6" "242.3" "256.1" "" "" "" "" "" "" "" "" "" "" "261.4" "214.5" "251.7" "229.2" "240.2" "253.6" "226.4" "214.5" "242.3" "246.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2922734994360900835" "False" "High" "IsMasterProtein" "P54198" "Protein HIRA OS=Homo sapiens OX=9606 GN=HIRA PE=1 SV=2" "0.000" "False" "5.697" "3" "3" "3" "3" "1017" "111.8" "8.07" "6.68" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf07569" "7290" "ENSG00000100084" "HIRA" "hsa:7290; P54198; Q05BU9; Q8IXN2" "22q11.2 copy number variation syndrome; 16p11.2 proximal deletion syndrome" "Replacement of protamines by nucleosomes in the male pronucleus; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "4" "0" "1.024" "0.932" "1.131" "1.156" "1.068" "1.196" "1.078" "1.350" "1.139" "135.4" "138.7" "126.2" "153.1" "156.5" "144.6" "162.0" "145.9" "182.8" "154.3" "" "" "" "" "" "" "" "" "" "" "126.9" "114.8" "117.2" "118.4" "133.4" "138.1" "148.0" "129.6" "182.8" "148.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-359770206824869393" "False" "High" "IsMasterProtein" "P50747" "Biotin--protein ligase OS=Homo sapiens OX=9606 GN=HLCS PE=1 SV=1" "0.000" "False" "5.694" "3" "3" "3" "3" "726" "80.7" "5.62" "6.96" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf02237, Pf03099" "3141" "ENSG00000159267" "HLCS" "B2RAH1; D3DSG6; hsa:3141; P50747; Q99451" "" "Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8120916206400470693" "False" "High" "IsMasterProtein" "O96006" "E3 SUMO-protein ligase ZBED1 OS=Homo sapiens OX=9606 GN=ZBED1 PE=1 SV=1" "0.000" "False" "5.687" "4" "2" "2" "2" "694" "78.1" "6.10" "2.50" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02892, Pf05699" "9189" "ENSG00000214717; ENSG00000292345" "ZBED1" "hsa:9189; O96006; Q96BY4" "" "SUMOylation of chromatin organization proteins" "1" "0" "1.018" "1.210" "1.060" "1.035" "1.078" "1.065" "0.977" "1.080" "1.122" "99.9" "101.7" "120.9" "105.9" "103.4" "107.7" "106.4" "97.6" "107.9" "112.1" "" "" "" "" "" "" "" "" "" "" "93.6" "84.2" "112.2" "81.9" "88.2" "102.9" "97.2" "86.7" "107.9" "107.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5634316393020217319" "False" "High" "IsMasterProtein" "Q5VZE5" "N-alpha-acetyltransferase 35, NatC auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA35 PE=1 SV=1" "0.000" "False" "5.686" "3" "2" "2" "2" "725" "83.6" "7.05" "5.38" "2" "cell cycle OR cell proliferation;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf04112" "60560" "ENSG00000135040" "NAA35" "hsa:60560; Q5VZE5; Q5VZE6; Q9H631; Q9H703" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8162637103249760299" "False" "High" "IsMasterProtein" "Q14CB8" "Rho GTPase-activating protein 19 OS=Homo sapiens OX=9606 GN=ARHGAP19 PE=1 SV=1" "0.000" "False" "5.685" "4" "2" "3" "2" "494" "55.7" "9.36" "5.95" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf00620" "84986" "ENSG00000213390" "ARHGAP19" "A1XCP1; B4DZR1; hsa:84986; Q14CB8; Q14CF2; Q5J8M2; Q5T460; Q5T462; Q68DG6; Q8N9X1; Q8NF34; Q8TEK1" "" "RHOA GTPase cycle" "1" "0" "1.195" "0.972" "1.381" "1.258" "0.941" "1.263" "1.095" "1.197" "1.078" "27.4" "32.8" "26.7" "37.9" "34.5" "25.8" "34.7" "30.0" "32.8" "29.6" "" "" "" "" "" "" "" "" "" "" "25.7" "27.1" "24.8" "29.3" "29.4" "24.7" "31.7" "26.7" "32.8" "28.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "357381019356623363" "False" "High" "IsMasterProtein" "Q15025" "TNFAIP3-interacting protein 1 OS=Homo sapiens OX=9606 GN=TNIP1 PE=1 SV=2" "0.000" "False" "5.682" "3" "2" "2" "2" "636" "71.8" "6.62" "5.54" "2" "cell adhesion;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "" "10318" "ENSG00000145901" "TNIP1" "A4F1W8; A4F1W9; A4F1X2; A4F1X4; A4F1X5; A4F1X6; A4F1X7; A4F1X9; B7Z699; E7EPY1; E7ET96; hsa:10318; O76008; Q05KP3; Q05KP4; Q15025; Q6N077; Q96EL9; Q99833; Q9H1J3" "RAC1/PAK1/p38/MMP2 pathway" "Ovarian tumor domain proteases" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7866416472238112790" "False" "High" "IsMasterProtein" "Q14061" "Cytochrome c oxidase copper chaperone OS=Homo sapiens OX=9606 GN=COX17 PE=1 SV=2" "0.000" "False" "5.677" "32" "2" "3" "2" "63" "6.9" "7.24" "7.26" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf05051" "10063" "ENSG00000138495" "COX17" "B2R5D2; D3DN84; hsa:10063; Q14061; Q3MHD6" "Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis; IL-18 signaling pathway; Mitochondrial complex IV assembly" "Mitochondrial protein import" "5" "0" "0.934" "0.953" "0.874" "0.887" "0.942" "0.867" "0.883" "0.845" "0.930" "132.4" "123.6" "126.2" "115.7" "117.5" "124.7" "114.8" "116.9" "111.9" "123.1" "" "" "" "" "" "" "" "" "" "" "124.0" "102.3" "117.2" "89.5" "100.1" "119.1" "104.9" "103.8" "111.9" "118.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4635662456929640047" "False" "High" "IsMasterProtein" "O15304" "Apoptosis regulatory protein Siva OS=Homo sapiens OX=9606 GN=SIVA1 PE=1 SV=2" "0.000" "False" "5.675" "9" "2" "2" "2" "175" "18.7" "7.61" "6.66" "2" "cell organization and biogenesis;transport;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05458" "10572" "ENSG00000184990" "SIVA1" "hsa:10572; O15304; Q96P98; Q9UPD6" "p53 transcriptional gene network" "" "1" "0" "0.946" "0.829" "1.027" "0.970" "0.940" "0.889" "1.040" "0.977" "0.903" "136.8" "129.4" "113.4" "140.6" "132.7" "128.7" "121.7" "142.3" "133.7" "123.5" "" "" "" "" "" "" "" "" "" "" "128.2" "107.1" "105.3" "108.7" "113.1" "122.9" "111.2" "126.3" "133.7" "118.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8652321965736247269" "False" "High" "IsMasterProtein" "Q8TCA0" "Leucine-rich repeat-containing protein 20 OS=Homo sapiens OX=9606 GN=LRRC20 PE=1 SV=1" "0.000" "False" "5.673" "9" "2" "2" "2" "184" "20.5" "6.55" "5.31" "2" "" "" "" "Pf13855" "55222" "ENSG00000172731" "LRRC20" "hsa:55222; Q5T6D4; Q5T6D6; Q8TCA0; Q9NVA6; Q9NVG3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7256809200695467141" "False" "High" "IsMasterProtein" "Q02083" "N-acylethanolamine-hydrolyzing acid amidase OS=Homo sapiens OX=9606 GN=NAAA PE=1 SV=3" "0.000" "False" "5.671" "7" "3" "3" "3" "359" "40.0" "8.75" "4.51" "3" "other metabolic processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02275, Pf15508" "27163" "ENSG00000138744" "NAAA" "hsa:27163; Q02083; Q5KTF2; Q96EY2; Q9BRA8" "" "Neurotransmitter release cycle" "1" "0" "0.980" "0.966" "1.121" "0.925" "1.049" "0.999" "0.983" "1.000" "0.981" "391.8" "383.9" "378.4" "439.1" "362.6" "411.1" "391.4" "385.1" "391.8" "384.3" "" "" "" "" "" "" "" "" "" "" "367.1" "317.6" "351.3" "339.5" "309.1" "392.8" "357.6" "342.0" "391.8" "370.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5032311727132364318" "False" "High" "IsMasterProtein" "Q8IVV7" "Glucose-induced degradation protein 4 homolog OS=Homo sapiens OX=9606 GN=GID4 PE=1 SV=1" "0.000" "False" "5.670" "8" "2" "2" "2" "300" "33.5" "9.16" "5.41" "2" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf09783" "79018" "ENSG00000141034" "GID4" "hsa:79018; Q8IVV7; Q8TEB5; Q9BW50" "Ciliary landscape; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8413874508331317204" "False" "High" "IsMasterProtein" "Q9NPA3" "Mid1-interacting protein 1 OS=Homo sapiens OX=9606 GN=MID1IP1 PE=1 SV=1" "0.000" "False" "5.665" "14" "2" "2" "2" "183" "20.2" "5.50" "5.72" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf07084" "58526" "ENSG00000165175" "MID1IP1" "D3DWB2; hsa:58526; Q9NPA3" "" "Carnitine metabolism" "1" "0" "0.982" "0.937" "0.894" "0.901" "0.977" "0.783" "0.785" "0.820" "0.872" "394.6" "387.6" "369.8" "352.9" "355.3" "385.4" "308.9" "309.9" "323.4" "344.0" "" "" "" "" "" "" "" "" "" "" "369.7" "320.7" "343.3" "272.8" "302.9" "368.2" "282.3" "275.2" "323.4" "331.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2825155014730555615" "False" "High" "IsMasterProtein" "Q6GMV2" "Histone-lysine N-trimethyltransferase SMYD5 OS=Homo sapiens OX=9606 GN=SMYD5 PE=1 SV=2" "0.000" "False" "5.663" "4" "2" "2" "2" "418" "47.3" "5.05" "4.68" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "" "other molecular function" "Pf00856" "10322" "ENSG00000135632" "SMYD5" "D6W5H3; hsa:10322; Q13558; Q6GMV2" "Histone modifications" "" "1" "0" "1.316" "1.232" "1.572" "0.952" "1.014" "0.845" "0.902" "0.881" "0.905" "71.0" "93.4" "87.4" "111.6" "67.6" "72.0" "60.0" "64.0" "62.6" "64.2" "" "" "" "" "" "" "" "" "" "" "66.5" "77.3" "81.2" "86.3" "57.6" "68.8" "54.8" "56.8" "62.6" "61.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3637812855525000132" "False" "High" "IsMasterProtein" "Q2KHR2" "DNA-binding protein RFX7 OS=Homo sapiens OX=9606 GN=RFX7 PE=1 SV=2" "0.000" "False" "5.661" "1" "2" "2" "1" "1460" "157.3" "6.61" "6.58" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257" "64864" "ENSG00000181827" "RFX7" "hsa:64864; Q2KHR2; Q6ZRR1; Q6ZTY6; Q8N3J0; Q9H7A9; Q9H956" "" "" "0" "0" "0.936" "0.946" "1.027" "1.041" "0.979" "0.939" "0.993" "1.003" "0.983" "137.3" "128.5" "129.9" "141.0" "142.9" "134.3" "128.9" "136.3" "137.7" "134.9" "" "" "" "" "" "" "" "" "" "" "128.6" "106.3" "120.6" "109.0" "121.8" "128.4" "117.8" "121.0" "137.7" "129.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3567158229513091577" "False" "High" "IsMasterProtein" "Q8NDX1" "PH and SEC7 domain-containing protein 4 OS=Homo sapiens OX=9606 GN=PSD4 PE=1 SV=2" "0.000" "False" "5.657" "2" "3" "3" "3" "1056" "116.2" "5.48" "5.45" "3" "other biological processes" "plasma membrane;other membranes" "enzyme regulator activity;other molecular function" "Pf01369, Pf15410" "23550" "ENSG00000125637" "PSD4" "A6NEG7; A8K1Y0; hsa:23550; O95621; Q4ZG34; Q6GPH8; Q8IYP4; Q8NDX1" "2q13 copy number variation syndrome" "" "1" "0" "1.078" "1.032" "1.018" "1.008" "0.998" "0.962" "0.891" "0.905" "0.933" "186.9" "201.5" "193.0" "190.4" "188.4" "186.6" "179.8" "166.6" "169.2" "174.4" "" "" "" "" "" "" "" "" "" "" "175.1" "166.8" "179.2" "147.1" "160.6" "178.3" "164.3" "147.9" "169.2" "167.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3408450596310404748" "False" "High" "IsMasterProtein" "Q9UHA4" "Ragulator complex protein LAMTOR3 OS=Homo sapiens OX=9606 GN=LAMTOR3 PE=1 SV=1" "0.000" "False" "5.650" "14" "2" "2" "2" "124" "13.6" "7.34" "7.12" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf08923" "8649" "ENSG00000109270" "LAMTOR3" "B2R4A1; hsa:8649; J3KMX4; Q9H364; Q9UHA4" "MAPK signaling pathway; MAPK cascade; Gastrin signaling pathway; Melanoma" "Neutrophil degranulation; mTORC1-mediated signalling; Regulation of PTEN gene transcription; MAP2K and MAPK activation; TP53 Regulates Metabolic Genes; Amino acids regulate mTORC1; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1058361017873513588" "False" "High" "IsMasterProtein" "P63173" "Large ribosomal subunit protein eL38 OS=Homo sapiens OX=9606 GN=RPL38 PE=1 SV=2" "0.000" "False" "5.649" "24" "2" "5" "2" "70" "8.2" "10.10" "14.89" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01781" "6169" "ENSG00000172809" "RPL38" "B2R5A8; hsa:6169; P23411; P63173" "Mesodermal commitment pathway; Mesodermal commitment pathway; Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Response of EIF2AK4 (GCN2) to amino acid deficiency; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "16" "0" "1.126" "1.133" "1.156" "1.404" "1.400" "1.344" "1.437" "1.392" "1.262" "578.4" "651.5" "655.1" "668.7" "811.8" "809.8" "777.1" "830.9" "804.8" "730.0" "" "" "" "" "" "" "" "" "" "" "541.9" "539.1" "608.1" "517.0" "692.0" "773.7" "710.0" "737.8" "804.8" "702.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1698483045954744258" "False" "High" "IsMasterProtein" "Q15018" "BRISC complex subunit Abraxas 2 OS=Homo sapiens OX=9606 GN=ABRAXAS2 PE=1 SV=2" "0.000" "False" "5.642" "8" "3" "3" "3" "415" "46.9" "6.21" "6.73" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf21125" "23172" "ENSG00000165660" "ABRAXAS2" "B4DKR2; hsa:23172; Q15018; Q96H11" "" "Metalloprotease DUBs" "1" "0" "1.911" "1.011" "1.572" "2.427" "1.349" "1.087" "1.142" "1.379" "1.110" "425.2" "812.4" "429.7" "668.6" "1031.8" "573.8" "462.4" "485.8" "586.5" "472.1" "" "" "" "" "" "" "" "" "" "" "398.4" "672.3" "399.0" "516.9" "879.5" "548.2" "422.5" "431.3" "586.5" "454.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8924414405991965446" "False" "High" "IsMasterProtein" "P98179" "RNA-binding protein 3 OS=Homo sapiens OX=9606 GN=RBM3 PE=1 SV=1" "0.000" "False" "5.635" "16" "2" "3" "2" "157" "17.2" "8.91" "11.11" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity" "Pf00076" "5935" "ENSG00000102317" "RBM3" "hsa:5935; P98179" "" "" "0" "0" "1.085" "1.002" "1.005" "1.042" "0.960" "0.883" "0.933" "0.975" "0.984" "447.1" "485.2" "448.1" "449.4" "465.8" "429.2" "394.8" "417.1" "435.8" "440.0" "" "" "" "" "" "" "" "" "" "" "418.9" "401.5" "416.0" "347.4" "397.0" "410.1" "360.8" "370.3" "435.8" "423.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1663461843225663368" "False" "High" "IsMasterProtein" "O00716" "Transcription factor E2F3 OS=Homo sapiens OX=9606 GN=E2F3 PE=1 SV=1" "0.000" "False" "5.635" "4" "2" "2" "2" "465" "49.1" "5.44" "7.13" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02319, Pf16421" "1871" "ENSG00000112242" "E2F3" "hsa:1871; O00716; Q15000; Q68DT0; Q9BZ44" "Cell cycle; Metastatic brain tumor; B cell receptor signaling pathway; Retinoblastoma gene in cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Small cell lung cancer; Melanoma; Nephrotic syndrome" "Oxidative Stress Induced Senescence; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; G2 Phase; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)" "17" "0" "0.960" "1.056" "1.040" "1.086" "1.050" "1.105" "1.069" "1.060" "1.101" "286.5" "275.2" "302.5" "298.1" "311.1" "300.8" "316.5" "306.2" "303.7" "315.3" "" "" "" "" "" "" "" "" "" "" "268.4" "227.7" "280.8" "230.4" "265.2" "287.4" "289.2" "271.9" "303.7" "303.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6677968596851833833" "False" "High" "IsMasterProtein" "Q9NXR8" "Inhibitor of growth protein 3 OS=Homo sapiens OX=9606 GN=ING3 PE=1 SV=2" "0.000" "False" "5.633" "6" "2" "2" "2" "418" "46.7" "6.27" "3.32" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12998" "54556" "ENSG00000071243" "ING3" "A8K790; hsa:54556; O60394; Q567P3; Q6GMT3; Q7Z762; Q969G0; Q96DT4; Q9HC99; Q9NXR8; Q9P081" "" "HATs acetylate histones" "1" "0" "1.083" "1.000" "1.413" "1.177" "1.071" "1.096" "1.199" "1.092" "0.852" "32.4" "35.1" "32.4" "45.8" "38.1" "34.7" "35.5" "38.9" "35.4" "27.6" "" "" "" "" "" "" "" "" "" "" "30.4" "29.0" "30.1" "35.4" "32.5" "33.2" "32.5" "34.5" "35.4" "26.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2149131157478544716" "False" "High" "IsMasterProtein" "Q6P587" "Oxaloacetate tautomerase FAHD1, mitochondrial OS=Homo sapiens OX=9606 GN=FAHD1 PE=1 SV=3" "0.000" "False" "5.633" "13" "3" "3" "3" "221" "24.5" "7.39" "5.80" "3" "" "" "" "" "" "" "" "" "" "" "0" "0" "0.984" "0.945" "1.034" "1.039" "1.144" "0.998" "1.023" "1.014" "1.008" "346.7" "341.1" "327.7" "358.5" "360.4" "396.5" "346.1" "354.5" "351.4" "349.4" "" "" "" "" "" "" "" "" "" "" "324.8" "282.2" "304.3" "277.1" "307.2" "378.8" "316.3" "314.7" "351.4" "336.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3010506436641867552" "False" "High" "IsMasterProtein" "Q8WWW0" "Ras association domain-containing protein 5 OS=Homo sapiens OX=9606 GN=RASSF5 PE=1 SV=1" "0.000" "False" "5.618" "5" "2" "2" "2" "418" "47.1" "9.14" "5.30" "2" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00130, Pf00788, Pf16517" "83593" "ENSG00000266094" "RASSF5" "A8K1E6; hsa:83593; Q5SY32; Q8WWV9; Q8WWW0; Q8WXF4; Q9BT99" "Fibrin complement receptor 3 signaling pathway; Ras signaling; Non-small cell lung cancer; Leukocyte-intrinsic Hippo pathway functions; Pleural mesothelioma" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3161881869701219173" "False" "High" "IsMasterProtein" "O43715" "TP53-regulated inhibitor of apoptosis 1 OS=Homo sapiens OX=9606 GN=TRIAP1 PE=1 SV=1" "0.000" "False" "5.615" "28" "2" "3" "2" "76" "8.8" "5.48" "11.20" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf05254" "51499" "ENSG00000170855" "TRIAP1" "B2R4Z7; hsa:51499; O43715; Q5RKS5; Q6LCA7" "5q35 copy number variation" "Mitochondrial protein degradation; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" "3" "0" "1.088" "1.097" "1.051" "1.100" "1.097" "0.937" "1.067" "0.949" "1.145" "468.7" "509.9" "514.2" "492.5" "515.6" "514.3" "439.2" "499.9" "444.6" "536.7" "" "" "" "" "" "" "" "" "" "" "439.2" "421.9" "477.4" "380.8" "439.5" "491.4" "401.3" "443.9" "444.6" "516.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3102131592095934236" "False" "High" "IsMasterProtein" "Q969G6" "Riboflavin kinase OS=Homo sapiens OX=9606 GN=RFK PE=1 SV=2" "0.000" "False" "5.612" "12" "2" "2" "2" "155" "17.6" "8.13" "7.00" "2" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf01687" "55312" "ENSG00000135002" "RFK" "hsa:55312; Q5JSG9; Q969G6; Q9NUT7" "Selenium micronutrient network; Folate metabolism; TNF-alpha signaling pathway" "Vitamin B2 (riboflavin) metabolism" "4" "0" "1.003" "1.053" "1.127" "1.080" "1.184" "1.048" "1.207" "1.116" "1.113" "94.1" "94.5" "99.1" "106.1" "101.6" "111.5" "98.7" "113.6" "105.0" "104.7" "" "" "" "" "" "" "" "" "" "" "88.2" "78.2" "92.0" "82.1" "86.6" "106.5" "90.2" "100.8" "105.0" "100.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1025854285268432181" "False" "High" "IsMasterProtein" "P56377" "AP-1 complex subunit sigma-2 OS=Homo sapiens OX=9606 GN=AP1S2 PE=1 SV=1" "0.000" "False" "5.610" "10" "2" "3" "1" "157" "18.6" "5.47" "9.48" "2" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "8905" "ENSG00000182287" "AP1S2" "B4DSU4; hsa:8905; O95326; P56377; Q9H2N6" "" "Golgi Associated Vesicle Biogenesis; MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "4" "0" "0.954" "0.993" "1.008" "1.038" "1.015" "0.913" "0.971" "0.930" "1.081" "210.6" "200.9" "209.2" "212.3" "218.6" "213.8" "192.2" "204.6" "195.8" "227.7" "" "" "" "" "" "" "" "" "" "" "197.4" "166.2" "194.2" "164.1" "186.3" "204.3" "175.6" "181.7" "195.8" "219.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-212858070142576811" "False" "High" "IsMasterProtein" "Q86VX2" "COMM domain-containing protein 7 OS=Homo sapiens OX=9606 GN=COMMD7 PE=1 SV=2" "0.000" "False" "5.606" "11" "2" "2" "2" "200" "22.5" "5.92" "6.45" "2" "signal transduction;other biological processes" "other cell component" "other molecular function" "Pf07258, Pf21672" "149951" "ENSG00000149600" "COMMD7" "A2BHJ2; B3KTZ2; hsa:149951; Q5JYB0; Q86VX2; Q96SI7; Q9BW53" "" "Neddylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4563498728879559184" "False" "High" "IsMasterProtein" "Q9BW71" "HIRA-interacting protein 3 OS=Homo sapiens OX=9606 GN=HIRIP3 PE=1 SV=3" "0.000" "False" "5.601" "3" "2" "3" "2" "556" "61.9" "8.54" "7.08" "2" "cell organization and biogenesis" "nucleus" "" "Pf09649" "8479" "ENSG00000149929" "HIRIP3" "H3BSR3; hsa:8479; O75707; O75708; Q9BW71" "22q11.2 copy number variation syndrome; 16p11.2 proximal deletion syndrome" "" "2" "0" "1.079" "0.994" "0.980" "1.031" "0.967" "1.207" "1.100" "1.112" "1.099" "498.4" "537.7" "495.3" "488.6" "514.1" "482.0" "601.8" "548.5" "554.1" "547.6" "" "" "" "" "" "" "" "" "" "" "467.0" "445.0" "459.8" "377.7" "438.2" "460.5" "549.8" "487.0" "554.1" "527.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6155932716542002822" "False" "High" "IsMasterProtein" "P06239" "Tyrosine-protein kinase Lck OS=Homo sapiens OX=9606 GN=LCK PE=1 SV=6" "0.000" "False" "5.587" "4" "2" "3" "1" "509" "58.0" "5.36" "7.94" "2" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "3932" "ENSG00000182866" "LCK" "D3DPP8; hsa:3932; P06239; P07100; Q12850; Q13152; Q5TDH8; Q5TDH9; Q7RTZ3; Q96DW4; Q9NYT8" "Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Inflammatory response pathway; Cancer immunotherapy by PD-1 blockade; IL-18 signaling pathway; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; IL-2 signaling pathway; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis; TAR syndrome; Interferon type I signaling pathways; Notch signaling pathway; T-cell receptor signaling pathway" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; DAP12 signaling; CD28 dependent PI3K/Akt signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Regulation of KIT signaling; RHOH GTPase cycle; CD28 dependent Vav1 pathway; Nef Mediated CD4 Down-regulation; Interleukin-2 signaling; Nef and signal transduction; PECAM1 interactions; CTLA4 inhibitory signaling; FLT3 signaling through SRC family kinases" "40" "0" "0.894" "0.879" "0.916" "0.911" "0.844" "0.835" "0.876" "0.866" "0.885" "696.0" "622.3" "611.5" "637.2" "634.1" "587.5" "581.0" "609.8" "602.6" "615.9" "" "" "" "" "" "" "" "" "" "" "652.1" "514.9" "567.7" "492.5" "540.5" "561.3" "530.9" "541.5" "602.6" "593.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7445573923015050179" "False" "High" "IsMasterProtein" "Q9BYC8" "Large ribosomal subunit protein bL32m OS=Homo sapiens OX=9606 GN=MRPL32 PE=1 SV=1" "0.000" "False" "5.583" "15" "2" "2" "2" "188" "21.4" "9.73" "7.52" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01783" "64983" "ENSG00000106591" "MRPL32" "hsa:64983; Q96Q68; Q9BYC8; Q9P098" "" "Mitochondrial protein degradation; Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "1.012" "0.950" "1.056" "1.075" "1.072" "1.049" "1.040" "0.988" "1.047" "436.6" "441.9" "414.6" "461.0" "469.5" "467.9" "458.1" "454.1" "431.4" "457.1" "" "" "" "" "" "" "" "" "" "" "409.1" "365.7" "384.9" "356.3" "400.2" "447.0" "418.6" "403.2" "431.4" "440.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6333223318553199487" "False" "High" "IsMasterProtein" "Q14919" "Dr1-associated corepressor OS=Homo sapiens OX=9606 GN=DRAP1 PE=1 SV=3" "0.000" "False" "5.579" "9" "2" "2" "2" "205" "22.3" "5.17" "3.89" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00808" "10589" "ENSG00000175550" "DRAP1" "hsa:10589; Q13448; Q14919" "" "Signaling by NODAL; Signaling by Activin" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6764296312378698476" "False" "High" "IsMasterProtein" "Q9UHJ3" "Scm-like with four MBT domains protein 1 OS=Homo sapiens OX=9606 GN=SFMBT1 PE=1 SV=2" "0.000" "False" "5.578" "2" "2" "2" "2" "866" "98.1" "6.21" "6.57" "2" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf00536, Pf02820, Pf12140" "51460" "ENSG00000163935" "SFMBT1" "hsa:51460; Q402F7; Q96C73; Q9UHJ3; Q9Y4Q9" "" "" "0" "0" "0.972" "0.965" "0.985" "1.043" "1.034" "1.085" "1.085" "1.031" "1.052" "390.8" "380.0" "377.3" "384.9" "407.7" "404.0" "424.0" "423.9" "402.9" "411.3" "" "" "" "" "" "" "" "" "" "" "366.2" "314.4" "350.3" "297.5" "347.5" "386.0" "387.5" "376.4" "402.9" "396.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8204162643568548731" "False" "High" "IsMasterProtein" "Q9HD47" "Ran guanine nucleotide release factor OS=Homo sapiens OX=9606 GN=RANGRF PE=1 SV=1" "0.000" "False" "5.574" "11" "2" "2" "2" "186" "20.4" "4.94" "7.13" "2" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04603" "29098" "ENSG00000108961" "RANGRF" "D3DTR6; hsa:29098; Q68DI3; Q9BR68; Q9HD47; Q9HD48; Q9NRU9; Q9P001; Q9P0P2" "" "Phase 0 - rapid depolarisation" "1" "0" "1.065" "0.971" "0.999" "1.019" "0.912" "0.918" "0.902" "1.012" "1.000" "255.4" "271.9" "248.0" "255.3" "260.4" "233.0" "234.5" "230.4" "258.6" "255.4" "" "" "" "" "" "" "" "" "" "" "239.3" "225.0" "230.2" "197.3" "221.9" "222.6" "214.3" "204.6" "258.6" "245.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5558995711693310036" "False" "High" "IsMasterProtein" "Q9BWW4" "Single-stranded DNA-binding protein 3 OS=Homo sapiens OX=9606 GN=SSBP3 PE=1 SV=1" "0.000" "False" "5.556" "5" "2" "3" "1" "388" "40.4" "6.90" "10.00" "2" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04503" "23648" "ENSG00000157216" "SSBP3" "A8K0A9; hsa:23648; Q5T860; Q5T861; Q9BTM0; Q9BWW3; Q9BWW4" "" "" "0" "1" "0.961" "0.943" "1.087" "1.000" "0.956" "1.005" "1.055" "0.977" "1.026" "297.7" "286.2" "280.6" "323.6" "297.6" "284.7" "299.2" "314.0" "290.8" "305.4" "" "" "" "" "" "" "" "" "" "" "279.0" "236.9" "260.5" "250.2" "253.7" "272.0" "273.4" "278.8" "290.8" "294.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9028825818345530826" "False" "High" "IsMasterProtein" "Q9UNZ5" "Leydig cell tumor 10 kDa protein homolog OS=Homo sapiens OX=9606 GN=C19orf53 PE=1 SV=1" "0.000" "False" "5.555" "17" "2" "2" "2" "99" "10.6" "11.55" "6.61" "2" "" "" "" "Pf09495" "28974" "ENSG00000104979" "C19orf53" "B2R4J9; hsa:28974; Q9UNZ5" "" "" "0" "0" "1.306" "1.210" "1.661" "1.217" "1.120" "0.982" "1.181" "1.141" "1.242" "251.5" "328.6" "304.3" "417.7" "306.2" "281.8" "247.0" "297.1" "287.1" "312.4" "" "" "" "" "" "" "" "" "" "" "235.7" "271.9" "282.5" "322.9" "261.0" "269.3" "225.7" "263.8" "287.1" "300.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-221730190353322517" "False" "High" "IsMasterProtein" "Q9UL63" "Muskelin OS=Homo sapiens OX=9606 GN=MKLN1 PE=1 SV=2" "0.000" "False" "5.552" "3" "2" "2" "2" "735" "84.7" "6.34" "5.63" "2" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01344, Pf06588, Pf13415" "4289" "ENSG00000128585" "MKLN1" "A4D1M8; A6NG43; hsa:4289; Q9NSK4; Q9NUS8; Q9UL63" "Ciliary landscape" "" "1" "0" "1.059" "1.057" "1.077" "1.013" "1.047" "0.996" "0.965" "1.035" "1.036" "185.0" "195.8" "195.5" "199.2" "187.4" "193.6" "184.3" "178.5" "191.5" "191.6" "" "" "" "" "" "" "" "" "" "" "173.3" "162.0" "181.5" "154.0" "159.7" "185.0" "168.4" "158.5" "191.5" "184.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4397574204075436679" "False" "High" "IsMasterProtein" "Q15013" "MAD2L1-binding protein OS=Homo sapiens OX=9606 GN=MAD2L1BP PE=1 SV=1" "0.000" "False" "5.548" "7" "2" "2" "2" "274" "31.0" "6.30" "2.94" "2" "other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "" "Pf06581" "9587" "ENSG00000124688" "MAD2L1BP" "B4DLV3; E9PAT7; hsa:9587; Q15013; Q6IBB1" "3q29 copy number variation syndrome" "" "1" "0" "1.155" "0.958" "1.408" "1.076" "0.869" "1.170" "1.027" "0.959" "0.977" "287.7" "332.2" "275.8" "405.2" "309.5" "250.1" "336.8" "295.5" "276.0" "281.1" "" "" "" "" "" "" "" "" "" "" "269.6" "274.9" "256.0" "313.3" "263.8" "238.9" "307.7" "262.4" "276.0" "270.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1706468280429092974" "False" "High" "IsMasterProtein" "Q9Y3S2" "Zinc finger protein 330 OS=Homo sapiens OX=9606 GN=ZNF330 PE=1 SV=1" "0.000" "False" "5.533" "5" "2" "4" "2" "320" "36.2" "6.16" "5.30" "2" "" "nucleus;other cell component" "other molecular function" "Pf06524" "27309" "ENSG00000109445" "ZNF330" "B2RDA3; hsa:27309; Q9Y3S2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8473500087346521620" "False" "High" "IsMasterProtein" "O43734" "E3 ubiquitin ligase TRAF3IP2 OS=Homo sapiens OX=9606 GN=TRAF3IP2 PE=1 SV=3" "0.000" "False" "5.532" "3" "2" "2" "2" "574" "64.6" "6.76" "6.57" "2" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf08357" "10758" "ENSG00000056972" "TRAF3IP2" "B2RAY9; E1P555; hsa:10758; O43734; Q5R3A3; Q7Z6Q1; Q7Z6Q2; Q7Z6Q3; Q9H5W2; Q9H6Y3; Q9NS14; Q9UG72" "IL-17 signaling pathway; VEGFA-VEGFR2 signaling" "" "2" "0" "1.168" "1.022" "1.135" "1.120" "1.161" "1.110" "1.090" "1.064" "1.148" "342.3" "399.8" "349.7" "388.5" "383.2" "397.2" "379.9" "373.1" "364.0" "392.9" "" "" "" "" "" "" "" "" "" "" "320.7" "330.8" "324.7" "300.4" "326.6" "379.5" "347.1" "331.3" "364.0" "378.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2679973573870526538" "False" "High" "IsMasterProtein" "P55347" "Homeobox protein PKNOX1 OS=Homo sapiens OX=9606 GN=PKNOX1 PE=1 SV=3" "0.000" "False" "5.531" "4" "2" "3" "2" "436" "47.6" "4.91" "5.62" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05920, Pf16493" "5316" "ENSG00000160199" "PKNOX1" "hsa:5316; O00528; P55347; Q8IWT7" "Sudden infant death syndrome (SIDS) susceptibility pathways" "Activation of anterior HOX genes in hindbrain development during early embryogenesis" "2" "0" "1.000" "0.944" "1.197" "1.087" "1.089" "1.057" "1.039" "0.993" "1.082" "190.7" "190.7" "180.0" "228.2" "207.3" "207.8" "201.6" "198.2" "189.3" "206.3" "" "" "" "" "" "" "" "" "" "" "178.7" "157.8" "167.1" "176.4" "176.7" "198.5" "184.2" "176.0" "189.3" "198.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6260636582982827540" "False" "High" "IsMasterProtein" "Q6YHU6" "tRNA (32-2'-O)-methyltransferase regulator THADA OS=Homo sapiens OX=9606 GN=THADA PE=1 SV=1" "0.000" "False" "5.528" "1" "2" "2" "2" "1953" "219.5" "6.06" "6.19" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;ER/Golgi" "enzyme regulator activity" "Pf10350" "63892" "ENSG00000115970" "THADA" "A8K1V8; B7WNS6; hsa:63892; Q3KR04; Q53RC6; Q53TB2; Q6YHU2; Q6YHU6; Q6ZU38; Q8IY32; Q8TAU8; Q96I88; Q9BZF7; Q9C096; Q9H6U0; Q9H6W7" "" "tRNA modification in the nucleus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2414902147837832753" "False" "High" "IsMasterProtein" "Q969R5" "Lethal(3)malignant brain tumor-like protein 2 OS=Homo sapiens OX=9606 GN=L3MBTL2 PE=1 SV=1" "0.000" "False" "5.527" "3" "2" "3" "1" "705" "79.1" "6.84" "9.11" "2" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf02820, Pf21319" "83746" "ENSG00000100395" "L3MBTL2" "hsa:83746; Q8TEN1; Q969R5; Q96SC4; Q9BQI2; Q9UGS4" "" "SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2402002904731644261" "False" "High" "IsMasterProtein" "Q9H0J9" "Protein mono-ADP-ribosyltransferase PARP12 OS=Homo sapiens OX=9606 GN=PARP12 PE=1 SV=1" "0.000" "False" "5.519" "3" "2" "2" "2" "701" "79.0" "8.51" "6.43" "2" "protein metabolism;other metabolic processes" "nucleus" "other molecular function" "Pf00642, Pf00644, Pf02825" "64761" "ENSG00000059378" "PARP12" "hsa:64761; Q9H0J9; Q9H610; Q9NP36; Q9NTI3" "" "" "0" "0" "1.120" "1.260" "1.095" "1.099" "1.027" "1.174" "1.105" "0.977" "1.099" "113.1" "126.6" "142.5" "123.8" "124.2" "116.1" "132.7" "125.0" "110.5" "124.3" "" "" "" "" "" "" "" "" "" "" "105.9" "104.8" "132.3" "95.7" "105.9" "110.9" "121.2" "111.0" "110.5" "119.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4234172936871541887" "False" "High" "IsMasterProtein" "Q9HA65" "TBC1 domain family member 17 OS=Homo sapiens OX=9606 GN=TBC1D17 PE=1 SV=3" "0.000" "False" "5.515" "3" "2" "2" "2" "648" "72.6" "5.21" "6.57" "2" "other metabolic processes;transport" "cytosol;other cytoplasmic organelle" "enzyme regulator activity" "Pf00566, Pf12068" "79735" "ENSG00000104946" "TBC1D17" "B4DT12; B9A6L8; F5H1W7; hsa:79735; Q9HA65" "" "TBC/RABGAPs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1130505086342919631" "False" "High" "IsMasterProtein" "Q99704" "Docking protein 1 OS=Homo sapiens OX=9606 GN=DOK1 PE=1 SV=1" "0.000" "False" "5.505" "3" "2" "2" "2" "481" "52.4" "6.47" "6.59" "2" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00169, Pf02174" "1796" "ENSG00000115325" "DOK1" "hsa:1796; O43204; Q53TY2; Q99704; Q9UHG6" "Kit receptor signaling pathway; VEGFA-VEGFR2 signaling; GDNF signaling" "RET signaling; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1" "5" "0" "0.919" "0.968" "0.983" "0.957" "0.929" "0.967" "0.926" "0.830" "0.923" "105.4" "96.9" "102.1" "103.7" "100.9" "98.0" "102.0" "97.7" "87.5" "97.3" "" "" "" "" "" "" "" "" "" "" "98.8" "80.2" "94.8" "80.2" "86.0" "93.6" "93.2" "86.7" "87.5" "93.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8782034775898615298" "False" "High" "IsMasterProtein" "Q96NC0" "Zinc finger matrin-type protein 2 OS=Homo sapiens OX=9606 GN=ZMAT2 PE=1 SV=1" "0.000" "False" "5.505" "11" "3" "5" "3" "199" "23.6" "9.01" "15.18" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf12171" "153527" "ENSG00000146007" "ZMAT2" "hsa:153527; Q96NC0" "" "mRNA Splicing - Major Pathway" "1" "0" "1.063" "0.952" "0.934" "0.880" "0.962" "1.040" "1.097" "1.077" "0.995" "333.4" "354.4" "317.4" "311.5" "293.5" "320.6" "346.9" "365.7" "359.2" "331.7" "" "" "" "" "" "" "" "" "" "" "312.4" "293.2" "294.7" "240.8" "250.2" "306.3" "317.0" "324.7" "359.2" "319.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-68439151188917529" "False" "High" "IsMasterProtein" "P50219" "Motor neuron and pancreas homeobox protein 1 OS=Homo sapiens OX=9606 GN=MNX1 PE=1 SV=3" "0.000" "False" "5.502" "5" "2" "2" "2" "401" "40.5" "7.68" "6.50" "2" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046" "3110" "ENSG00000130675" "MNX1" "F5H401; hsa:3110; P50219; Q9Y648" "" "" "0" "0" "1.023" "0.964" "0.953" "0.996" "1.143" "0.942" "0.924" "0.974" "1.068" "191.2" "195.7" "184.4" "182.2" "190.6" "218.7" "180.2" "176.7" "186.2" "204.3" "" "" "" "" "" "" "" "" "" "" "179.2" "162.0" "171.2" "140.9" "162.4" "208.9" "164.6" "156.9" "186.2" "196.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6799320046678325900" "False" "High" "IsMasterProtein" "Q13506" "NGFI-A-binding protein 1 OS=Homo sapiens OX=9606 GN=NAB1 PE=1 SV=2" "0.000" "False" "5.496" "3" "2" "3" "1" "487" "54.4" "6.70" "9.43" "2" "developmental processes;other biological processes" "nucleus" "other molecular function" "Pf04902, Pf04904, Pf04905" "4664" "ENSG00000138386" "NAB1" "hsa:4664; O75383; O75384; Q13506; Q6GTU1; Q9UEV1" "" "NGF-stimulated transcription; EGR2 and SOX10-mediated initiation of Schwann cell myelination" "2" "0" "1.088" "1.022" "1.100" "1.094" "1.087" "1.096" "1.070" "1.069" "1.180" "233.7" "254.3" "238.8" "257.2" "255.7" "253.9" "256.2" "250.2" "249.8" "275.8" "" "" "" "" "" "" "" "" "" "" "219.0" "210.4" "221.7" "198.8" "217.9" "242.6" "234.1" "222.1" "249.8" "265.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4539117867176903484" "False" "High" "IsMasterProtein" "P50402" "Emerin OS=Homo sapiens OX=9606 GN=EMD PE=1 SV=1" "0.000" "False" "5.496" "8" "2" "2" "2" "254" "29.0" "5.50" "6.02" "2" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity" "Pf03020" "2010" "ENSG00000102119" "EMD" "hsa:2010; P50402; Q6FI02" "Arrhythmogenic right ventricular cardiomyopathy; Envelope proteins and their potential roles in EDMD physiopathology; Influence of laminopathies on Wnt signaling" "RHOG GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina" "12" "0" "1.142" "1.034" "1.162" "1.229" "1.212" "1.168" "1.241" "1.197" "1.168" "208.1" "237.7" "215.2" "241.8" "255.8" "252.1" "243.0" "258.3" "249.2" "243.0" "" "" "" "" "" "" "" "" "" "" "195.0" "196.7" "199.8" "186.9" "218.1" "240.9" "222.0" "229.3" "249.2" "234.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7069915122482910766" "False" "High" "IsMasterProtein" "Q9Y2I7" "1-phosphatidylinositol 3-phosphate 5-kinase OS=Homo sapiens OX=9606 GN=PIKFYVE PE=1 SV=3" "0.000" "False" "5.494" "1" "2" "2" "2" "2098" "237.0" "6.70" "5.61" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00118, Pf00610, Pf01363, Pf01504" "200576" "ENSG00000115020" "PIKFYVE" "hsa:200576; Q08AR7; Q08AR8; Q53ST3; Q53T36; Q8N5H0; Q8NB67; Q9Y2I7" "" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "3" "0" "1.038" "0.987" "0.982" "1.022" "1.046" "1.069" "0.899" "1.001" "1.036" "496.5" "515.2" "490.2" "487.9" "507.3" "519.6" "530.8" "446.3" "497.3" "514.6" "" "" "" "" "" "" "" "" "" "" "465.3" "426.3" "455.1" "377.1" "432.4" "496.4" "485.0" "396.3" "497.3" "495.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4307491490075501206" "False" "High" "IsMasterProtein" "P32322" "Pyrroline-5-carboxylate reductase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PYCR1 PE=1 SV=2" "0.000" "False" "5.491" "6" "2" "4" "2" "319" "33.3" "7.61" "12.08" "2" "other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf03807, Pf14748" "5831" "ENSG00000183010" "PYCR1" "A6NFM2; B4DMU0; hsa:5831; P32322; Q6FHI4; Q96DI6; Q9HBQ4" "Amino acid metabolism; Metabolic reprogramming in colon cancer" "Glutamate and glutamine metabolism" "3" "0" "1.094" "1.110" "1.084" "1.026" "0.981" "0.944" "1.091" "1.014" "1.031" "265.5" "290.3" "294.6" "287.7" "272.4" "260.5" "250.7" "289.7" "269.3" "273.7" "" "" "" "" "" "" "" "" "" "" "248.8" "240.3" "273.5" "222.4" "232.2" "248.9" "229.1" "257.2" "269.3" "263.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5833411024047299895" "False" "High" "IsMasterProtein" "Q02156" "Protein kinase C epsilon type OS=Homo sapiens OX=9606 GN=PRKCE PE=1 SV=1" "0.000" "False" "5.484" "4" "2" "2" "2" "737" "83.6" "7.12" "6.48" "2" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00130, Pf00168, Pf00433" "5581" "ENSG00000171132" "PRKCE" "B0LPH7; hsa:5581; Q02156; Q32MQ3; Q53SL4; Q53SM5; Q9UE81" "Physiological and pathological hypertrophy of the heart; Oncostatin M signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency; Non-genomic actions of 1,25 dihydroxyvitamin D3; Hippo signaling regulation pathways; Gastrin signaling pathway; Osteoblast differentiation and related diseases; Kisspeptin/kisspeptin receptor system in the ovary; Opioid receptor pathways; Orexin receptor pathway; Chronic hyperglycemia impairment of neuron function; Calcium regulation in cardiac cells; HDAC6 interactions in the central nervous system" "Role of phospholipids in phagocytosis; G alpha (z) signalling events; SHC1 events in ERBB2 signaling; DAG and IP3 signaling; Effects of PIP2 hydrolysis" "21" "0" "1.014" "0.888" "1.330" "1.178" "0.909" "1.106" "1.024" "0.921" "0.980" "57.7" "58.6" "51.3" "76.8" "68.0" "52.5" "63.8" "59.1" "53.2" "56.6" "" "" "" "" "" "" "" "" "" "" "54.1" "48.5" "47.6" "59.4" "58.0" "50.2" "58.3" "52.5" "53.2" "54.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1443587214663370681" "False" "High" "IsMasterProtein" "Q9UKD1" "Glucocorticoid modulatory element-binding protein 2 OS=Homo sapiens OX=9606 GN=GMEB2 PE=1 SV=1" "0.000" "False" "5.479" "5" "3" "3" "3" "530" "56.4" "5.60" "7.12" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01342" "26205" "ENSG00000101216" "GMEB2" "E1P5J3; hsa:26205; Q5TDS0; Q9H431; Q9H4X7; Q9H4X8; Q9UF78; Q9UKD1; Q9ULF1" "" "" "0" "0" "0.924" "0.966" "0.865" "0.956" "1.128" "0.892" "0.927" "0.947" "1.047" "125.1" "115.5" "120.9" "108.2" "119.5" "141.1" "111.5" "115.9" "118.4" "130.9" "" "" "" "" "" "" "" "" "" "" "117.2" "95.6" "112.2" "83.6" "101.9" "134.8" "101.9" "102.9" "118.4" "126.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1283281267783462391" "False" "High" "IsMasterProtein" "Q7L4P6" "BEN domain-containing protein 5 OS=Homo sapiens OX=9606 GN=BEND5 PE=1 SV=1" "0.000" "False" "5.477" "4" "2" "2" "2" "421" "48.2" "6.20" "5.65" "2" "other biological processes" "ER/Golgi" "nucleic acid binding activity" "Pf10523" "79656" "ENSG00000162373" "BEND5" "D3DQ27; hsa:79656; Q7L4P6; Q96A62; Q9HAI3" "" "" "0" "0" "1.166" "1.141" "1.278" "1.202" "1.129" "1.343" "1.106" "1.031" "1.074" "117.6" "137.1" "134.2" "150.2" "141.4" "132.8" "157.9" "130.1" "121.3" "126.3" "" "" "" "" "" "" "" "" "" "" "110.2" "113.4" "124.6" "116.1" "120.5" "126.8" "144.3" "115.5" "121.3" "121.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3408617602849881412" "False" "High" "IsMasterProtein" "Q9UKU7" "Isobutyryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAD8 PE=1 SV=1" "0.000" "False" "5.475" "4" "2" "2" "2" "415" "45.0" "7.85" "6.27" "2" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "27034" "ENSG00000151498" "ACAD8" "B7Z5W4; hsa:27034; Q6ZWP6; Q9BUS8; Q9UKU7" "" "Mitochondrial protein degradation; Branched-chain amino acid catabolism" "2" "0" "1.022" "1.091" "1.005" "1.019" "1.039" "1.007" "1.028" "0.946" "1.103" "209.8" "214.3" "228.8" "210.9" "213.9" "217.9" "211.2" "215.7" "198.5" "231.4" "" "" "" "" "" "" "" "" "" "" "196.6" "177.3" "212.5" "163.0" "182.3" "208.2" "193.0" "191.5" "198.5" "222.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2802895978922525693" "False" "High" "IsMasterProtein" "O15151" "Protein Mdm4 OS=Homo sapiens OX=9606 GN=MDM4 PE=1 SV=2" "0.000" "False" "5.473" "5" "2" "2" "2" "490" "54.8" "5.00" "4.92" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00641, Pf13920" "4194" "ENSG00000198625" "MDM4" "hsa:4194; O15151; Q2M2Y2; Q32SL2; Q6GS18; Q8IV83" "Glioblastoma signaling pathways; Pleural mesothelioma" "Ub-specific processing proteases; Regulation of TP53 Degradation; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Oncogene Induced Senescence; Regulation of TP53 Activity through Methylation; Stabilization of p53" "9" "0" "1.058" "1.041" "1.074" "1.044" "1.127" "1.040" "1.005" "1.033" "1.015" "198.7" "210.2" "206.8" "213.3" "207.4" "224.0" "206.6" "199.7" "205.2" "201.7" "" "" "" "" "" "" "" "" "" "" "186.2" "174.0" "191.9" "164.9" "176.8" "214.0" "188.7" "177.4" "205.2" "194.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4691271095298353856" "False" "High" "IsMasterProtein" "Q13114" "TNF receptor-associated factor 3 OS=Homo sapiens OX=9606 GN=TRAF3 PE=1 SV=2" "0.000" "False" "5.469" "3" "2" "2" "2" "568" "64.4" "7.91" "6.33" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02176, Pf21355, Pf21363" "7187" "ENSG00000131323" "TRAF3" "B7Z8C4; hsa:7187; Q12990; Q13076; Q13114; Q13947; Q6AZX1; Q9UNL1" "RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; IL-17 signaling pathway; Apoptosis; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; Oxidative damage response; miRNA role in immune response in sepsis; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; Type I interferon induction and signaling during SARS-CoV-2 infection; Activation of NLRP3 inflammasome by SARS-CoV-2; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; 2q37 copy number variation syndrome; 13q12.12 copy number variation; Toll-like receptor signaling pathway" "Ovarian tumor domain proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; Negative regulators of DDX58/IFIH1 signaling; TRAF3 deficiency - HSE; TICAM1-dependent activation of IRF3/IRF7; SARS-CoV-1 activates/modulates innate immune responses; TRAF3-dependent IRF activation pathway" "35" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8316251485158664462" "False" "High" "IsMasterProtein" "Q8N8A6" "ATP-dependent RNA helicase DDX51 OS=Homo sapiens OX=9606 GN=DDX51 PE=1 SV=3" "0.000" "False" "5.459" "4" "2" "2" "2" "666" "72.4" "8.16" "6.16" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271" "317781" "ENSG00000185163; ENSG00000288503" "DDX51" "A8MPT9; hsa:317781; Q5CZ71; Q8IXK5; Q8N8A6; Q96ED1" "" "" "0" "0" "1.014" "1.191" "1.201" "1.123" "1.090" "1.204" "1.162" "1.188" "1.127" "133.9" "135.8" "159.5" "160.8" "150.4" "146.0" "161.3" "155.6" "159.1" "151.0" "" "" "" "" "" "" "" "" "" "" "125.5" "112.4" "148.1" "124.3" "128.2" "139.5" "147.4" "138.1" "159.1" "145.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2213528751694895262" "False" "High" "IsMasterProtein" "Q8N2W9" "E3 SUMO-protein ligase PIAS4 OS=Homo sapiens OX=9606 GN=PIAS4 PE=1 SV=1" "0.000" "False" "5.458" "3" "2" "2" "2" "510" "56.5" "6.14" "6.58" "2" "cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02891, Pf14324" "51588" "ENSG00000105229" "PIAS4" "O75926; Q8N2W9; Q96G19; Q9UN16" "Androgen receptor signaling pathway" "SUMOylation of intracellular receptors; Nonhomologous End-Joining (NHEJ); SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of DNA replication proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription cofactors; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; SUMOylation of immune response proteins" "14" "0" "0.911" "1.034" "0.891" "0.921" "0.999" "0.859" "0.953" "0.965" "1.003" "435.1" "396.4" "449.8" "387.7" "400.7" "434.5" "373.8" "414.6" "420.1" "436.6" "" "" "" "" "" "" "" "" "" "" "407.7" "328.0" "417.6" "299.7" "341.6" "415.1" "341.6" "368.1" "420.1" "420.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-579603406694116788" "False" "High" "IsMasterProtein" "Q9H0C5" "BTB/POZ domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BTBD1 PE=1 SV=1" "0.000" "False" "5.455" "4" "2" "3" "1" "482" "52.7" "6.10" "9.06" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00651, Pf07707, Pf08005" "53339" "ENSG00000064726" "BTBD1" "A6NMI8; hsa:53339; Q9BX71; Q9H0C5; Q9NWN4" "15q25 copy number variation" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "3" "0" "1.023" "1.002" "0.959" "0.907" "1.025" "0.916" "0.829" "0.851" "0.929" "229.4" "234.7" "230.0" "220.0" "208.2" "235.1" "210.1" "190.3" "195.3" "213.2" "" "" "" "" "" "" "" "" "" "" "215.0" "194.2" "213.5" "170.1" "177.4" "224.7" "191.9" "169.0" "195.3" "205.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1124967282390941354" "False" "High" "IsMasterProtein" "Q9HB90" "Ras-related GTP-binding protein C OS=Homo sapiens OX=9606 GN=RRAGC PE=1 SV=1" "0.000" "False" "5.451" "5" "2" "2" "2" "399" "44.2" "5.10" "5.24" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04670" "64121" "ENSG00000116954" "RRAGC" "hsa:64121; Q9H202; Q9H8Q8; Q9HB90" "Target of rapamycin signaling; Orexin receptor pathway; 2q37 copy number variation syndrome" "Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Amino acids regulate mTORC1; mTORC1-mediated signalling; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "10" "0" "0.941" "1.047" "1.020" "1.061" "1.054" "1.067" "1.022" "1.132" "1.117" "148.8" "140.0" "155.8" "151.7" "157.9" "156.7" "158.8" "152.0" "168.4" "166.2" "" "" "" "" "" "" "" "" "" "" "139.4" "115.8" "144.6" "117.3" "134.6" "149.8" "145.1" "135.0" "168.4" "160.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9088787272925242729" "False" "High" "IsMasterProtein" "Q9C0D3" "Protein zyg-11 homolog B OS=Homo sapiens OX=9606 GN=ZYG11B PE=1 SV=2" "0.000" "False" "5.439" "3" "2" "3" "2" "744" "83.9" "6.86" "7.19" "2" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "" "" "79699" "ENSG00000162378" "ZYG11B" "hsa:79699; Q8N2X3; Q9C0D3; Q9H8L8" "Ciliary landscape; Hijack of ubiquitination by SARS-CoV-2" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3564377166653415060" "False" "High" "IsMasterProtein" "Q5JS54" "Proteasome assembly chaperone 4 OS=Homo sapiens OX=9606 GN=PSMG4 PE=1 SV=2" "0.000" "False" "5.430" "28" "2" "3" "2" "123" "13.8" "6.52" "14.40" "2" "cell organization and biogenesis" "other cell component" "other molecular function" "Pf16093" "389362" "ENSG00000180822" "PSMG4" "C9J2F8; F8WBZ2; hsa:389362; Q5JS53; Q5JS54; Q5JS56" "" "" "0" "0" "0.904" "0.776" "0.996" "1.081" "0.766" "0.735" "1.001" "0.820" "0.752" "45.2" "40.8" "35.1" "45.0" "48.9" "34.6" "33.2" "45.2" "37.0" "34.0" "" "" "" "" "" "" "" "" "" "" "42.3" "33.8" "32.6" "34.8" "41.6" "33.1" "30.3" "40.1" "37.0" "32.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5860754846925802701" "False" "High" "IsMasterProtein" "O95400" "CD2 antigen cytoplasmic tail-binding protein 2 OS=Homo sapiens OX=9606 GN=CD2BP2 PE=1 SV=1" "0.000" "False" "5.425" "8" "2" "2" "2" "341" "37.6" "4.61" "4.04" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02213" "10421" "ENSG00000169217" "CD2BP2" "B2RDX2; hsa:10421; O95400; Q9ULP2" "mRNA processing; Ciliary landscape" "" "2" "0" "1.178" "0.945" "1.292" "0.995" "0.998" "1.244" "1.218" "1.208" "1.179" "51.6" "60.8" "48.7" "66.6" "51.3" "51.5" "64.2" "62.8" "62.3" "60.8" "" "" "" "" "" "" "" "" "" "" "48.3" "50.3" "45.2" "51.5" "43.8" "49.2" "58.6" "55.8" "62.3" "58.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4980915021063436064" "False" "High" "IsMasterProtein" "Q9H944" "Mediator of RNA polymerase II transcription subunit 20 OS=Homo sapiens OX=9606 GN=MED20 PE=1 SV=1" "0.000" "False" "5.425" "10" "2" "2" "2" "212" "23.2" "6.87" "7.45" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf08612" "9477" "ENSG00000124641" "MED20" "B4DE08; hsa:9477; O95821; Q5T8J4; Q9H944; Q9Y429" "" "Generic Transcription Pathway; Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; RSV-host interactions" "4" "0" "1.075" "0.994" "1.020" "0.970" "0.903" "1.090" "0.995" "0.982" "1.007" "218.5" "235.0" "217.1" "222.9" "211.9" "197.4" "238.1" "217.3" "214.5" "219.9" "" "" "" "" "" "" "" "" "" "" "204.7" "194.4" "201.5" "172.3" "180.7" "188.6" "217.5" "192.9" "214.5" "211.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5668169265399271149" "False" "High" "IsMasterProtein" "Q8N9N5" "Protein BANP OS=Homo sapiens OX=9606 GN=BANP PE=1 SV=3" "0.000" "False" "5.422" "4" "2" "2" "2" "519" "56.5" "5.49" "6.71" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf10523" "54971" "ENSG00000172530" "BANP" "A8MU25; A8MX25; B2RCF7; B4DNJ9; F5GZM0; hsa:54971; Q8N9N5; Q96GJ7; Q9NWY1" "" "Regulation of TP53 Activity through Association with Co-factors" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8563797319587415269" "False" "High" "IsMasterProtein" "P25208" "Nuclear transcription factor Y subunit beta OS=Homo sapiens OX=9606 GN=NFYB PE=1 SV=2" "0.000" "False" "5.409" "10" "2" "2" "2" "207" "22.8" "4.59" "6.18" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "4801" "ENSG00000120837" "NFYB" "A8K7B9; hsa:4801; P25208; Q96IY8" "" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum stress; ATF6 (ATF6-alpha) activates chaperone genes" "5" "0" "0.989" "1.001" "0.849" "1.020" "1.017" "1.035" "1.001" "0.942" "0.928" "217.2" "214.8" "217.4" "184.5" "221.5" "220.8" "224.8" "217.3" "204.6" "201.7" "" "" "" "" "" "" "" "" "" "" "203.5" "177.8" "201.8" "142.6" "188.8" "211.0" "205.4" "193.0" "204.6" "194.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6666677363642983444" "False" "High" "IsMasterProtein" "O75182" "Paired amphipathic helix protein Sin3b OS=Homo sapiens OX=9606 GN=SIN3B PE=1 SV=2" "0.000" "False" "5.399" "2" "2" "2" "2" "1162" "133.0" "6.93" "5.51" "2" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf02671, Pf08295, Pf16879" "23309" "ENSG00000127511" "SIN3B" "hsa:23309; O75182; Q2NL91; Q68GC2; Q6P4B8; Q8TB34; Q9BSC8" "" "NoRC negatively regulates rRNA expression; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "2" "0" "0.990" "0.962" "0.934" "0.933" "0.985" "0.936" "0.892" "0.896" "0.880" "156.4" "154.9" "150.5" "146.1" "146.0" "154.1" "146.4" "139.5" "140.2" "137.7" "" "" "" "" "" "" "" "" "" "" "146.6" "128.2" "139.7" "112.9" "124.5" "147.3" "133.8" "123.8" "140.2" "132.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7116132215439268199" "False" "High" "IsMasterProtein" "Q6ZRQ5" "Protein MMS22-like OS=Homo sapiens OX=9606 GN=MMS22L PE=1 SV=3" "0.000" "False" "5.399" "1" "2" "2" "2" "1243" "142.2" "7.12" "5.69" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf14910, Pf14911" "253714" "ENSG00000146263" "MMS22L" "D6R9Y8; D6RBQ4; E1P529; hsa:253714; Q5THT2; Q68CQ6; Q68D32; Q6ZRQ5" "" "" "0" "0" "0.995" "1.091" "1.059" "1.038" "0.989" "1.093" "1.208" "1.068" "1.070" "307.0" "305.4" "334.9" "325.0" "318.6" "303.6" "335.6" "370.8" "328.0" "328.4" "" "" "" "" "" "" "" "" "" "" "287.6" "252.7" "310.9" "251.2" "271.6" "290.0" "306.7" "329.2" "328.0" "316.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3754812835242028685" "False" "High" "IsMasterProtein" "Q6ZSR9" "Uncharacterized protein FLJ45252 OS=Homo sapiens OX=9606 PE=1 SV=2" "0.000" "False" "5.382" "7" "2" "2" "2" "355" "38.0" "5.26" "7.52" "2" "" "" "" "Pf15282" "" "" "" "" "" "" "0" "0" "0.996" "0.933" "1.075" "1.056" "0.958" "1.044" "0.975" "0.831" "0.889" "619.5" "616.9" "578.0" "666.3" "654.4" "593.3" "647.1" "604.1" "515.1" "550.8" "" "" "" "" "" "" "" "" "" "" "580.5" "510.5" "536.6" "515.1" "557.8" "566.9" "591.2" "536.4" "515.1" "530.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1532626323839813541" "False" "High" "IsMasterProtein" "Q99622" "Protein C10 OS=Homo sapiens OX=9606 GN=C12orf57 PE=1 SV=1" "0.000" "False" "5.378" "19" "2" "2" "2" "126" "13.2" "5.14" "4.48" "2" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf14974" "113246" "ENSG00000111678" "C12orf57" "B2R4Q6; hsa:113246; Q99622" "" "" "0" "0" "1.079" "1.034" "1.153" "1.186" "1.054" "1.083" "1.126" "1.069" "1.156" "201.9" "217.8" "208.8" "232.8" "239.4" "212.7" "218.6" "227.3" "215.8" "233.4" "" "" "" "" "" "" "" "" "" "" "189.1" "180.2" "193.8" "179.9" "204.0" "203.2" "199.7" "201.8" "215.8" "224.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8051417909882487765" "False" "High" "IsMasterProtein" "Q14562" "ATP-dependent RNA helicase DHX8 OS=Homo sapiens OX=9606 GN=DHX8 PE=1 SV=1" "0.000" "False" "5.368" "1" "2" "2" "2" "1220" "139.2" "8.32" "5.18" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00270, Pf00271, Pf00575, Pf04408, Pf07717, Pf21010" "1659" "ENSG00000067596" "DHX8" "hsa:1659; Q14562" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.001" "1.039" "1.091" "1.084" "1.061" "1.169" "1.275" "1.227" "1.062" "178.8" "179.0" "185.7" "195.1" "193.9" "189.7" "209.0" "228.0" "219.3" "189.8" "" "" "" "" "" "" "" "" "" "" "167.5" "148.1" "172.4" "150.8" "165.2" "181.2" "191.0" "202.4" "219.3" "182.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3393024407889637945" "False" "High" "IsMasterProtein" "P63027" "Vesicle-associated membrane protein 2 OS=Homo sapiens OX=9606 GN=VAMP2 PE=1 SV=3" "0.000" "False" "5.364" "20" "2" "2" "2" "116" "12.7" "8.13" "5.68" "2" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00957" "6844" "ENSG00000220205" "VAMP2" "hsa:6844; P19065; P63027; Q9BUC2" "Synaptic vesicle pathway; Insulin signaling; 7q11.23 copy number variation syndrome; Galanin receptor pathway; Vasopressin-regulated water reabsorption; Sudden infant death syndrome (SIDS) susceptibility pathways" "Sensory processing of sound by inner hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Glutamate Neurotransmitter Release Cycle; Regulation of insulin secretion; Insulin processing; Cargo recognition for clathrin-mediated endocytosis; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; GABA synthesis, release, reuptake and degradation; Other interleukin signaling; Toxicity of tetanus toxin (tetX); Toxicity of botulinum toxin type B (botB); Toxicity of botulinum toxin type D (botD); Toxicity of botulinum toxin type G (botG); Toxicity of botulinum toxin type F (botF)" "28" "0" "0.977" "0.960" "1.056" "0.990" "1.037" "1.068" "0.983" "0.960" "0.939" "339.8" "331.8" "326.1" "358.9" "336.4" "352.4" "363.0" "334.0" "326.1" "319.0" "" "" "" "" "" "" "" "" "" "" "318.3" "274.6" "302.7" "277.4" "286.7" "336.7" "331.7" "296.5" "326.1" "307.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2541081725476023529" "False" "High" "IsMasterProtein" "Q8NBJ7" "Inactive C-alpha-formylglycine-generating enzyme 2 OS=Homo sapiens OX=9606 GN=SUMF2 PE=1 SV=2" "0.000" "False" "5.363" "8" "2" "3" "2" "301" "33.8" "8.00" "6.44" "2" "" "ER/Golgi" "other molecular function" "Pf03781" "25870" "ENSG00000129103" "SUMF2" "B4DU41; B4DWQ0; hsa:25870; Q14DW5; Q53ZE3; Q8NBJ7; Q96BH2; Q9BRN3; Q9BWI1; Q9Y405" "" "Glycosphingolipid catabolism; The activation of arylsulfatases" "2" "0" "0.932" "0.881" "0.896" "0.903" "0.945" "0.894" "0.997" "0.971" "0.928" "259.4" "241.9" "228.6" "232.4" "234.2" "245.2" "231.9" "258.7" "251.8" "240.7" "" "" "" "" "" "" "" "" "" "" "243.1" "200.1" "212.2" "179.7" "199.6" "234.2" "211.9" "229.7" "251.8" "231.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "484436176042567230" "False" "High" "IsMasterProtein" "P02686" "Myelin basic protein OS=Homo sapiens OX=9606 GN=MBP PE=1 SV=3" "0.000" "False" "5.362" "5" "2" "2" "2" "304" "33.1" "9.79" "6.18" "2" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf01669" "4155" "ENSG00000197971" "MBP" "A4FU54; A6NI84; A8MY86; A8MYL4; B3KY66; B7ZKS2; B7ZKS4; hsa:4155; P02686; Q15337; Q15338; Q15339; Q15340; Q59GX3; Q65ZS4; Q6AI64; Q6FH37; Q6FI04; Q6PK23" "Neural crest differentiation; Glial cell differentiation; Spinal cord injury; Interleukin-1 (IL-1) structural pathway; MECP2 and associated Rett syndrome; MAPK cascade; Complement system in neuronal development and plasticity; Opioid receptor pathways; Cell lineage map for neuronal differentiation" "EGR2 and SOX10-mediated initiation of Schwann cell myelination" "10" "0" "1.057" "1.024" "1.049" "0.897" "0.772" "0.779" "0.745" "0.856" "0.855" "98.9" "104.5" "101.3" "103.8" "88.8" "76.3" "77.1" "73.7" "84.7" "84.6" "" "" "" "" "" "" "" "" "" "" "92.7" "86.5" "94.1" "80.3" "75.7" "72.9" "70.4" "65.4" "84.7" "81.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3452513591771994158" "False" "High" "IsMasterProtein" "Q6ICG6" "Uncharacterized protein KIAA0930 OS=Homo sapiens OX=9606 GN=KIAA0930 PE=1 SV=1" "0.000" "False" "5.355" "4" "2" "4" "2" "404" "45.8" "7.94" "7.57" "2" "" "" "" "Pf09741" "23313" "ENSG00000100364" "KIAA0930" "B0QY17; B0QY19; B3KT48; hsa:23313; Q6ICG6; Q6ZVE5; Q7Z6K9; Q8IZ76; Q9Y2E2" "" "" "0" "0" "1.216" "1.003" "1.313" "1.044" "1.099" "1.245" "1.000" "1.125" "1.045" "39.9" "48.5" "40.0" "52.4" "41.7" "43.9" "49.7" "39.9" "44.9" "41.7" "" "" "" "" "" "" "" "" "" "" "37.4" "40.2" "37.2" "40.5" "35.5" "41.9" "45.4" "35.4" "44.9" "40.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1775190888259302728" "False" "High" "IsMasterProtein" "Q6P2C8" "Mediator of RNA polymerase II transcription subunit 27 OS=Homo sapiens OX=9606 GN=MED27 PE=1 SV=1" "0.000" "False" "5.339" "7" "2" "2" "2" "311" "35.4" "9.31" "5.52" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf11571" "9442" "ENSG00000160563" "MED27" "hsa:9442; O95401; Q4F964; Q5VTA4; Q5VTA5; Q6P2C8; Q9BU57; Q9NYR4; V9GYV9" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "0.951" "0.976" "0.985" "1.037" "1.051" "0.971" "0.984" "1.058" "1.093" "581.3" "552.6" "567.4" "572.6" "602.7" "610.9" "564.5" "571.8" "614.8" "635.6" "" "" "" "" "" "" "" "" "" "" "544.7" "457.3" "526.8" "442.6" "513.7" "583.7" "515.8" "507.7" "614.8" "612.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "251219974824346079" "False" "High" "IsMasterProtein" "Q05D32" "CTD small phosphatase-like protein 2 OS=Homo sapiens OX=9606 GN=CTDSPL2 PE=1 SV=2" "0.000" "False" "5.337" "6" "3" "3" "3" "466" "53.0" "6.40" "7.52" "3" "transport;other biological processes" "nucleus" "other molecular function" "Pf03031" "51496" "ENSG00000137770" "CTDSPL2" "hsa:51496; Q05D32; Q3ZTU1; Q6AI06; Q8IYI9; Q9NVT2; Q9NZX8; Q9P030" "" "" "0" "0" "0.989" "1.006" "1.129" "1.093" "1.092" "1.221" "1.137" "1.174" "1.114" "491.8" "486.6" "494.6" "555.2" "537.7" "536.9" "600.5" "559.3" "577.4" "547.8" "" "" "" "" "" "" "" "" "" "" "460.8" "402.7" "459.1" "429.2" "458.3" "512.9" "548.7" "496.6" "577.4" "527.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5036196760614096612" "False" "High" "IsMasterProtein" "P11802" "Cyclin-dependent kinase 4 OS=Homo sapiens OX=9606 GN=CDK4 PE=1 SV=2" "0.000" "False" "5.334" "7" "2" "3" "1" "303" "33.7" "7.01" "10.80" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "1019" "ENSG00000135446" "CDK4" "B2R9A0; B4DNF9; hsa:1019; O00576; P11802; Q6FG61" "miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Spinal cord injury; Retinoblastoma gene in cancer; Bladder cancer; PPAR-alpha pathway; Nuclear receptors meta-pathway; Ovarian infertility; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; PI3K-Akt signaling pathway; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Sphingolipid metabolism in senescence; DYRK1A involvement regarding cell proliferation in brain development; TROP2 regulatory signaling; JAK-STAT signaling in the regulation of beta cells; DNA damage response" "Oxidative Stress Induced Senescence; Transcriptional regulation of white adipocyte differentiation; Ubiquitin-dependent degradation of Cyclin D; SCF(Skp2)-mediated degradation of p27/p21; Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Senescence-Associated Secretory Phenotype (SASP); RMTs methylate histone arginines; Transcriptional regulation by RUNX2; Meiotic recombination; Transcriptional regulation of granulopoiesis; PTK6 Regulates Cell Cycle; Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4; Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4; Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Drug-mediated inhibition of CDK4/CDK6 activity" "47" "0" "0.876" "0.858" "1.020" "1.131" "1.032" "1.000" "0.859" "0.864" "0.947" "65.6" "57.4" "56.2" "66.8" "74.2" "67.7" "65.6" "56.3" "56.6" "62.1" "" "" "" "" "" "" "" "" "" "" "61.4" "47.5" "52.2" "51.7" "63.2" "64.6" "59.9" "50.0" "56.6" "59.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5995744781224398015" "False" "High" "IsMasterProtein" "P10746" "Uroporphyrinogen-III synthase OS=Homo sapiens OX=9606 GN=UROS PE=1 SV=1" "0.000" "False" "5.333" "7" "2" "2" "2" "265" "28.6" "5.48" "5.78" "2" "other metabolic processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf02602" "7390" "ENSG00000188690" "UROS" "B2RC13; D3DRF7; hsa:7390; P10746; Q9H2T1" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "3" "0" "0.970" "1.065" "1.168" "1.166" "1.070" "1.087" "1.058" "1.118" "1.194" "236.9" "229.7" "252.4" "276.6" "276.2" "253.4" "257.4" "250.7" "264.7" "282.8" "" "" "" "" "" "" "" "" "" "" "222.0" "190.1" "234.3" "213.8" "235.4" "242.1" "235.2" "222.6" "264.7" "272.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-929965012723082693" "False" "High" "IsMasterProtein" "Q969E4" "Transcription elongation factor A protein-like 3 OS=Homo sapiens OX=9606 GN=TCEAL3 PE=1 SV=1" "0.000" "False" "5.332" "15" "2" "2" "2" "200" "22.5" "4.92" "5.42" "2" "" "nucleus" "" "Pf04538" "85012" "ENSG00000196507" "TCEAL3" "D3DXA4; hsa:85012; Q969E4" "" "" "0" "0" "0.938" "0.953" "0.844" "0.869" "0.745" "0.520" "0.634" "0.631" "0.855" "61.4" "57.6" "58.5" "51.8" "53.4" "45.7" "31.9" "38.9" "38.7" "52.5" "" "" "" "" "" "" "" "" "" "" "57.5" "47.6" "54.3" "40.0" "45.5" "43.7" "29.2" "34.6" "38.7" "50.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3331965257696457103" "False" "High" "IsMasterProtein" "Q9H467" "CUE domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CUEDC2 PE=1 SV=1" "0.000" "False" "5.318" "6" "2" "2" "2" "287" "32.0" "4.81" "5.38" "2" "other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf02845" "79004" "ENSG00000107874" "CUEDC2" "D3DR88; hsa:79004; Q9BWG8; Q9H467" "" "" "0" "0" "1.014" "0.897" "0.820" "0.993" "1.016" "0.914" "0.939" "0.891" "0.982" "431.3" "437.5" "386.9" "353.7" "428.4" "438.1" "394.3" "405.0" "384.5" "423.4" "" "" "" "" "" "" "" "" "" "" "404.1" "362.0" "359.2" "273.4" "365.2" "418.6" "360.3" "359.6" "384.5" "407.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3774842769131475239" "False" "High" "IsMasterProtein" "Q9Y2R5" "Small ribosomal subunit protein uS17m OS=Homo sapiens OX=9606 GN=MRPS17 PE=1 SV=1" "0.000" "False" "5.307" "14" "2" "2" "2" "130" "14.5" "9.85" "4.79" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity" "Pf00366" "51373" "ENSG00000239789" "MRPS17" "hsa:51373; Q86X15; Q9Y2R5" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.246" "1.417" "1.243" "1.187" "1.202" "1.038" "1.108" "1.063" "1.258" "55.2" "68.8" "78.2" "68.6" "65.6" "66.4" "57.3" "61.2" "58.7" "69.5" "" "" "" "" "" "" "" "" "" "" "51.7" "57.0" "72.6" "53.1" "55.9" "63.4" "52.4" "54.3" "58.7" "66.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4927987348987010712" "False" "High" "IsMasterProtein" "P35790" "Choline kinase alpha OS=Homo sapiens OX=9606 GN=CHKA PE=1 SV=3" "0.000" "False" "5.305" "4" "2" "2" "2" "457" "52.2" "6.55" "6.83" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01633" "1119" "ENSG00000110721" "CHKA" "hsa:1119; P35790; Q8NE29" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Acetylcholine synthesis" "Synthesis of PC; Synthesis of PE" "6" "0" "1.027" "1.033" "1.084" "1.075" "1.008" "1.085" "1.192" "1.110" "1.090" "572.2" "587.5" "591.4" "620.2" "615.0" "576.7" "621.2" "681.9" "635.2" "623.9" "" "" "" "" "" "" "" "" "" "" "536.2" "486.1" "549.0" "479.4" "524.2" "551.0" "567.6" "605.4" "635.2" "600.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2332005078854859868" "False" "High" "IsMasterProtein" "Q9BWT6" "Meiotic nuclear division protein 1 homolog OS=Homo sapiens OX=9606 GN=MND1 PE=1 SV=1" "0.000" "False" "5.304" "10" "2" "3" "2" "205" "23.7" "8.19" "8.24" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism" "nucleus" "nucleic acid binding activity" "Pf03962, Pf18517" "84057" "ENSG00000121211" "MND1" "B2R5F9; hsa:84057; Q9BWT6" "Primary ovarian insufficiency" "Meiotic recombination" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6593306489055453789" "False" "High" "IsMasterProtein" "Q96EK4" "THAP domain-containing protein 11 OS=Homo sapiens OX=9606 GN=THAP11 PE=1 SV=2" "0.000" "False" "5.304" "8" "3" "3" "3" "314" "34.4" "8.98" "7.83" "3" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05485" "57215" "ENSG00000168286" "THAP11" "A4UCT5; A8K002; hsa:57215; O94795; Q96EK4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5356528915824417311" "False" "High" "IsMasterProtein" "Q7RTS9" "Dymeclin OS=Homo sapiens OX=9606 GN=DYM PE=1 SV=1" "0.000" "False" "5.301" "3" "2" "2" "2" "669" "75.9" "5.86" "5.87" "2" "cell organization and biogenesis;developmental processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf09742" "54808" "ENSG00000141627" "DYM" "A8K5I8; B2RCF9; B4DKI7; hsa:54808; Q3ZTS8; Q6P2P5; Q7RTS9; Q8N2M0; Q9BVE9; Q9NPU7" "" "" "0" "0" "0.973" "0.894" "0.990" "0.990" "0.967" "0.887" "0.830" "0.920" "0.861" "239.9" "233.5" "214.5" "237.5" "237.4" "231.9" "212.8" "199.0" "220.8" "206.6" "" "" "" "" "" "" "" "" "" "" "224.8" "193.2" "199.2" "183.6" "202.4" "221.6" "194.5" "176.7" "220.8" "198.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8719462215085106760" "False" "High" "IsMasterProtein" "Q8N983" "Large ribosomal subunit protein mL43 OS=Homo sapiens OX=9606 GN=MRPL43 PE=1 SV=1" "0.000" "False" "5.300" "8" "2" "2" "2" "215" "23.4" "8.65" "7.12" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf05047" "84545" "ENSG00000055950" "MRPL43" "B1AL06; B1AL07; B1AL09; B1AL10; C9J5Q3; D3DR71; hsa:84545; Q5JW06; Q7Z719; Q7Z7H6; Q86XN1; Q8N983; Q9BYC7" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.178" "1.141" "1.167" "1.141" "1.254" "1.217" "1.218" "1.148" "1.175" "205.0" "241.5" "233.9" "239.3" "234.0" "257.1" "249.5" "249.7" "235.3" "240.8" "" "" "" "" "" "" "" "" "" "" "192.1" "199.9" "217.2" "185.0" "199.5" "245.6" "228.0" "221.8" "235.3" "231.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3785691322693480288" "False" "High" "IsMasterProtein" "O95834" "Echinoderm microtubule-associated protein-like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1" "0.000" "False" "5.291" "3" "2" "2" "2" "649" "70.6" "6.32" "5.51" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451" "24139" "ENSG00000125746" "EML2" "B7Z3I2; B7Z3Q9; hsa:24139; K7ERL7; O95834; Q59EN8; Q8N5A2; Q9UG50" "" "" "0" "0" "1.285" "1.016" "1.265" "1.163" "1.188" "1.325" "1.147" "1.252" "1.025" "32.0" "41.1" "32.5" "40.4" "37.2" "38.0" "42.4" "36.7" "40.1" "32.8" "" "" "" "" "" "" "" "" "" "" "30.0" "34.0" "30.2" "31.3" "31.7" "36.3" "38.7" "32.6" "40.1" "31.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3901447341290801043" "False" "High" "IsMasterProtein" "Q66PJ3" "ADP-ribosylation factor-like protein 6-interacting protein 4 OS=Homo sapiens OX=9606 GN=ARL6IP4 PE=1 SV=3" "0.000" "False" "5.288" "10" "2" "2" "2" "237" "26.4" "10.86" "5.40" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf10500" "51329" "ENSG00000182196" "ARL6IP4" "A4UCR8; B3V0L0; B3V0L1; hsa:51329; Q4F966; Q504R8; Q66PJ3; Q96BI2; Q9NR05; Q9P2R9" "" "" "0" "0" "1.036" "0.990" "0.910" "0.971" "0.992" "0.882" "0.855" "0.871" "0.919" "393.6" "407.6" "389.6" "358.3" "382.1" "390.5" "347.1" "336.5" "342.7" "361.7" "" "" "" "" "" "" "" "" "" "" "368.8" "337.3" "361.7" "277.0" "325.7" "373.1" "317.1" "298.8" "342.7" "348.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-536665306058471520" "False" "High" "IsMasterProtein" "Q07020" "Large ribosomal subunit protein eL18 OS=Homo sapiens OX=9606 GN=RPL18 PE=1 SV=2" "0.000" "False" "5.286" "11" "2" "2" "2" "188" "21.6" "11.72" "5.63" "2" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf17135" "6141" "ENSG00000063177" "RPL18" "F8VWC5; hsa:6141; Q07020; Q8WTZ6" "Cytoplasmic ribosomal proteins" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.996" "1.097" "1.117" "1.194" "1.085" "1.175" "1.155" "1.111" "1.114" "145.7" "145.1" "159.9" "162.8" "174.0" "158.1" "171.2" "168.4" "161.9" "162.4" "" "" "" "" "" "" "" "" "" "" "136.6" "120.1" "148.5" "125.9" "148.3" "151.0" "156.5" "149.5" "161.9" "156.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6974141516308557016" "False" "High" "IsMasterProtein" "Q969T9" "WW domain-binding protein 2 OS=Homo sapiens OX=9606 GN=WBP2 PE=1 SV=1" "0.000" "False" "5.277" "7" "2" "2" "2" "261" "28.1" "5.91" "5.38" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02893" "23558" "ENSG00000132471" "WBP2" "B4DFG2; O95638; Q969T9" "" "" "0" "0" "1.117" "1.071" "1.016" "1.099" "1.113" "1.060" "1.017" "1.121" "1.027" "316.7" "353.7" "339.1" "321.7" "348.1" "352.3" "335.7" "322.1" "354.9" "325.3" "" "" "" "" "" "" "" "" "" "" "296.7" "292.6" "314.8" "248.7" "296.8" "336.6" "306.8" "286.0" "354.9" "313.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7302016058410828571" "False" "High" "IsMasterProtein" "O75940" "Survival of motor neuron-related-splicing factor 30 OS=Homo sapiens OX=9606 GN=SMNDC1 PE=1 SV=1" "0.000" "False" "5.270" "9" "2" "2" "2" "238" "26.7" "7.24" "4.98" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf06003" "10285" "ENSG00000119953" "SMNDC1" "B2RA27; D3DRB1; hsa:10285; O75940; Q5T3K6" "" "mRNA Splicing - Major Pathway" "1" "0" "1.048" "0.980" "0.999" "1.054" "1.067" "1.099" "1.115" "1.043" "1.090" "377.3" "395.3" "369.6" "377.1" "397.7" "402.6" "414.9" "420.5" "393.5" "411.3" "" "" "" "" "" "" "" "" "" "" "353.6" "327.1" "343.1" "291.5" "339.0" "384.7" "379.1" "373.4" "393.5" "396.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6163739139500016116" "False" "High" "IsMasterProtein" "Q9BSQ5" "Cerebral cavernous malformations 2 protein OS=Homo sapiens OX=9606 GN=CCM2 PE=1 SV=1" "0.000" "False" "5.269" "4" "2" "2" "2" "444" "48.8" "5.54" "5.86" "2" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "mitochondrion;other cell component" "" "Pf16545" "83605" "ENSG00000136280" "CCM2" "A4D2L4; B3KUV0; D3DVL4; E9PDJ3; F5H0E1; F5H551; hsa:83605; Q71RE5; Q8TAT4; Q9BSQ5" "" "" "0" "0" "0.970" "1.052" "0.961" "1.008" "1.010" "0.954" "1.034" "1.034" "0.930" "119.4" "115.8" "125.6" "114.7" "120.4" "120.6" "114.0" "123.5" "123.5" "111.1" "" "" "" "" "" "" "" "" "" "" "111.9" "95.8" "116.6" "88.7" "102.6" "115.2" "104.1" "109.6" "123.5" "107.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7724686332336547987" "False" "High" "IsMasterProtein" "Q5JPI9" "EEF1A lysine methyltransferase 2 OS=Homo sapiens OX=9606 GN=EEF1AKMT2 PE=1 SV=2" "0.000" "False" "5.260" "11" "2" "2" "2" "291" "31.8" "6.16" "3.29" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13847" "399818" "ENSG00000203791" "EEF1AKMT2" "A8MPY7; Q5JPI9" "" "Protein methylation" "1" "0" "1.173" "1.266" "1.086" "1.195" "1.268" "1.086" "0.968" "1.146" "1.221" "80.1" "93.9" "101.4" "87.0" "95.7" "101.5" "86.9" "77.5" "91.8" "97.8" "" "" "" "" "" "" "" "" "" "" "75.0" "77.7" "94.1" "67.2" "81.6" "97.0" "79.4" "68.8" "91.8" "94.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6029605810403186632" "False" "High" "IsMasterProtein" "Q14674" "Separin OS=Homo sapiens OX=9606 GN=ESPL1 PE=1 SV=3" "0.000" "False" "5.250" "1" "2" "2" "2" "2120" "233.0" "7.55" "6.14" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03568" "9700" "ENSG00000135476" "ESPL1" "hsa:9700; Q14674" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; Urotensin-II-mediated signaling pathway" "Separation of Sister Chromatids" "4" "0" "1.096" "1.122" "1.247" "1.203" "1.012" "1.100" "1.049" "1.099" "1.139" "109.3" "119.8" "122.7" "136.3" "131.5" "110.7" "120.2" "114.7" "120.2" "124.5" "" "" "" "" "" "" "" "" "" "" "102.4" "99.2" "113.9" "105.4" "112.1" "105.7" "109.8" "101.8" "120.2" "119.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7463196673493200714" "False" "High" "IsMasterProtein" "P01116" "GTPase KRas OS=Homo sapiens OX=9606 GN=KRAS PE=1 SV=1" "0.000" "False" "5.248" "10" "2" "3" "1" "189" "21.6" "6.77" "10.76" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00071" "3845" "ENSG00000133703" "KRAS" "A8K8Z5; B0LPF9; hsa:3845; P01116; P01118; Q96D10" "IL-5 signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Oncostatin M signaling pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; MAPK pathway in congenital thyroid cancer; Regulation of actin cytoskeleton; Alzheimer's disease; Acute myeloid leukemia; Autophagy in pancreatic ductal adenocarcinoma; JAK-STAT signaling in the regulation of beta cells; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling" "Signaling by CSF3 (G-CSF); Signaling by CSF1 (M-CSF) in myeloid cells; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAS GAP mutants; Signaling by RAS GTPase mutants; RUNX3 regulates p14-ARF" "60" "1" "0.955" "0.966" "1.008" "0.977" "0.960" "0.905" "0.977" "0.946" "0.979" "393.5" "375.8" "379.9" "396.7" "384.6" "377.8" "356.1" "384.3" "372.1" "385.2" "" "" "" "" "" "" "" "" "" "" "368.7" "311.0" "352.7" "306.7" "327.8" "360.9" "325.4" "341.3" "372.1" "370.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3819928772784180698" "False" "High" "IsMasterProtein" "Q03001" "Dystonin OS=Homo sapiens OX=9606 GN=DST PE=1 SV=4" "0.000" "False" "5.228" "0" "3" "3" "1" "7570" "860.1" "5.25" "7.54" "3" "cell adhesion;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf00681, Pf02187, Pf13499, Pf17902, Pf18373, Pf21019, Pf21020, Pf21097" "667" "ENSG00000151914" "DST" "B7Z3H1; E7ERU0; hsa:667; O94833; Q03001; Q12825; Q13266; Q13267; Q13775; Q5TBT0; Q5TBT2; Q5TF23; Q5TF24; Q8N1T8; Q8N8J3; Q8WXK8; Q8WXK9; Q96AK9; Q96DQ5; Q96J76; Q96QT5; Q9H555; Q9UGD7; Q9UGD8; Q9UN10" "" "RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Type I hemidesmosome assembly" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5299456138050834551" "False" "High" "IsMasterProtein" "O00115" "Deoxyribonuclease-2-alpha OS=Homo sapiens OX=9606 GN=DNASE2 PE=1 SV=2" "0.000" "False" "5.214" "5" "2" "2" "2" "360" "39.6" "8.05" "7.46" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf03265" "1777" "ENSG00000105612" "DNASE2" "B2RD06; B7Z4K6; hsa:1777; O00115; O43910" "" "Lysosome Vesicle Biogenesis" "1" "0" "1.095" "1.001" "1.020" "1.009" "0.987" "0.947" "1.023" "0.953" "1.012" "312.2" "341.7" "312.6" "318.5" "314.9" "308.2" "295.8" "319.3" "297.6" "316.1" "" "" "" "" "" "" "" "" "" "" "292.5" "282.8" "290.2" "246.3" "268.4" "294.5" "270.2" "283.5" "297.6" "304.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1629654953317171872" "False" "High" "IsMasterProtein" "Q68CP9" "AT-rich interactive domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ARID2 PE=1 SV=2" "0.000" "False" "5.205" "1" "2" "2" "2" "1835" "197.3" "7.42" "5.19" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01388, Pf02257" "196528" "ENSG00000189079" "ARID2" "Q15KG9; Q5EB51; Q645I3; Q68CP9; Q6ZRY5; Q7Z3I5; Q86T28; Q96SJ6; Q9HCL5" "" "RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "2" "0" "0.950" "1.003" "1.074" "0.955" "0.901" "1.233" "0.859" "0.854" "0.922" "62.5" "59.3" "62.7" "67.1" "59.7" "56.3" "77.0" "53.7" "53.4" "57.6" "" "" "" "" "" "" "" "" "" "" "58.6" "49.1" "58.2" "51.9" "50.9" "53.8" "70.4" "47.7" "53.4" "55.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1465431971745530473" "False" "High" "IsMasterProtein" "Q3KRA9" "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 OS=Homo sapiens OX=9606 GN=ALKBH6 PE=1 SV=2" "0.000" "False" "5.203" "7" "2" "3" "2" "238" "26.5" "8.78" "8.63" "2" "" "nucleus;other cell component" "other molecular function" "Pf13532" "84964" "ENSG00000239382" "ALKBH6" "A5LGM8; A6NLP1; A8MU96; hsa:84964; Q3KRA9" "" "" "0" "0" "0.945" "0.952" "1.033" "1.011" "0.994" "0.919" "0.946" "0.900" "1.007" "391.0" "369.4" "372.4" "403.9" "395.4" "388.7" "359.4" "369.8" "351.9" "393.8" "" "" "" "" "" "" "" "" "" "" "366.3" "305.7" "345.7" "312.2" "337.0" "371.4" "328.4" "328.3" "351.9" "379.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2428159041387120762" "False" "High" "IsMasterProtein" "Q9Y664" "KICSTOR complex protein kaptin OS=Homo sapiens OX=9606 GN=KPTN PE=1 SV=2" "0.000" "False" "5.203" "4" "2" "2" "2" "436" "48.1" "5.26" "4.92" "2" "cell organization and biogenesis;stress response;other biological processes" "other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "" "11133" "ENSG00000118162" "KPTN" "B3KN86; B4DQ76; hsa:11133; Q96GT1; Q9Y664" "" "Amino acids regulate mTORC1" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1703927075416448593" "False" "High" "IsMasterProtein" "P07477" "Serine protease 1 OS=Homo sapiens OX=9606 GN=PRSS1 PE=1 SV=1" "0.000" "False" "5.184" "8" "1" "3" "1" "247" "26.5" "6.51" "8.00" "1" "cell organization and biogenesis;protein metabolism;other biological processes" "non-structural extracellular" "other molecular function" "Pf00089" "5644" "ENSG00000204983; ENSG00000274247" "PRSS1" "A1A509; A6NJ71; B2R5I5; hsa:5644; P07477; Q5NV57; Q7M4N3; Q7M4N4; Q92955; Q9HAN4; Q9HAN5; Q9HAN6; Q9HAN7" "" "Uptake of dietary cobalamins into enterocytes; Activation of Matrix Metalloproteinases" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5417113921000243817" "False" "High" "IsMasterProtein" "Q5JPI3" "Uncharacterized protein C3orf38 OS=Homo sapiens OX=9606 GN=C3orf38 PE=1 SV=1" "0.000" "False" "5.182" "5" "2" "2" "2" "329" "37.5" "6.47" "6.22" "2" "other biological processes" "nucleus" "" "Pf15008" "285237" "ENSG00000179021" "C3orf38" "B2R8X6; hsa:285237; Q5JPI3; Q8TC85" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4812205563963537221" "False" "High" "IsMasterProtein" "Q9BSH5" "Haloacid dehalogenase-like hydrolase domain-containing protein 3 OS=Homo sapiens OX=9606 GN=HDHD3 PE=1 SV=1" "0.000" "False" "5.181" "6" "2" "2" "2" "251" "28.0" "6.71" "6.97" "2" "" "nucleus;other cell component" "" "Pf00702" "81932" "ENSG00000119431" "HDHD3" "B2RD47; hsa:81932; Q9BSH5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4655855300014543961" "False" "High" "IsMasterProtein" "Q06330" "Recombining binding protein suppressor of hairless OS=Homo sapiens OX=9606 GN=RBPJ PE=1 SV=3" "0.000" "False" "5.176" "4" "2" "3" "2" "500" "55.6" "7.18" "7.06" "2" "cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09270, Pf09271, Pf20144" "3516" "ENSG00000168214" "RBPJ" "B4DY22; hsa:3516; Q06330; Q5XKH9; Q6P1N3" "Neural crest differentiation; Notch signaling; Canonical and non-canonical Notch signaling; PTF1A related regulatory pathway; Epithelial to mesenchymal transition in colorectal cancer; Osteoblast differentiation and related diseases; Genetic causes of porto-sinusoidal vascular disease; Notch signaling pathway" "Somitogenesis; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH2 intracellular domain regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "20" "0" "1.200" "0.940" "1.277" "1.006" "1.020" "1.143" "1.030" "1.019" "1.003" "380.1" "456.3" "357.2" "485.3" "382.2" "387.6" "434.6" "391.4" "387.5" "381.3" "" "" "" "" "" "" "" "" "" "" "356.1" "377.5" "331.6" "375.2" "325.8" "370.3" "397.1" "347.5" "387.5" "367.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4764020307768204184" "False" "High" "IsMasterProtein" "P61586" "Transforming protein RhoA OS=Homo sapiens OX=9606 GN=RHOA PE=1 SV=1" "0.000" "False" "5.168" "13" "2" "2" "2" "193" "21.8" "6.10" "4.48" "2" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "387" "ENSG00000067560" "RHOA" "hsa:387; P06749; P61586; Q53HM4; Q5U024; Q9UDJ0; Q9UEJ4" "Androgen receptor signaling pathway; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Leptin signaling pathway; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; Focal adhesion; G protein signaling pathways; Wnt signaling pathway; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency; Fibrin complement receptor 3 signaling pathway; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Leukocyte-intrinsic Hippo pathway functions; Neural crest cell migration during development; Neural crest cell migration in cancer; Joubert syndrome; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; GDNF signaling; PtdIns(4,5)P2 in cytokinesis pathway; 2q11.2 copy number variation syndrome; 2q21.1 copy number variation syndrome; G13 signaling pathway; 13q12.12 copy number variation; GNAQ pathways in port-wine stain; DNA damage response (only ATM dependent); Serotonin HTR1 group and FOS pathway" "Neutrophil degranulation; VEGFA-VEGFR2 Pathway; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHO GTPases Activate Formins; EPHB-mediated forward signaling; GPVI-mediated activation cascade; PI3K/AKT activation; ERBB2 Regulates Cell Motility; RHO GTPases activate CIT; G beta:gamma signalling through PI3Kgamma; PCP/CE pathway; RHO GTPases Activate Rhotekin and Rhophilins; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; Sema4D mediated inhibition of cell attachment and migration; Ovarian tumor domain proteases; SLIT2:ROBO1 increases RHOA activity; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Axonal growth stimulation; Axonal growth inhibition (RHOA activation); RHO GTPases activate KTN1" "71" "0" "1.193" "1.129" "1.037" "0.901" "0.879" "1.037" "0.909" "0.950" "0.955" "389.4" "464.4" "439.6" "403.7" "350.7" "342.2" "403.9" "354.0" "369.8" "372.0" "" "" "" "" "" "" "" "" "" "" "364.9" "384.3" "408.1" "312.1" "299.0" "327.0" "369.1" "314.3" "369.8" "358.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "147053636108274367" "False" "High" "IsMasterProtein" "Q08AE8" "Protein spire homolog 1 OS=Homo sapiens OX=9606 GN=SPIRE1 PE=1 SV=3" "0.000" "False" "5.167" "3" "2" "2" "2" "756" "85.5" "8.62" "6.80" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity" "Pf16474" "56907" "ENSG00000134278" "SPIRE1" "A8K2B5; hsa:56907; J3KQ50; J3KQR5; Q08AE8; Q1RMD4; Q8NDP1; Q9NQ71; Q9ULT4" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.978" "1.047" "1.073" "1.096" "0.934" "0.962" "0.975" "0.891" "0.934" "106.7" "104.4" "111.7" "114.5" "117.0" "99.7" "102.7" "104.0" "95.1" "99.7" "" "" "" "" "" "" "" "" "" "" "100.0" "86.4" "103.7" "88.5" "99.7" "95.2" "93.8" "92.4" "95.1" "96.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3062599375234318027" "False" "High" "IsMasterProtein" "Q02447" "Transcription factor Sp3 OS=Homo sapiens OX=9606 GN=SP3 PE=1 SV=3" "0.000" "False" "5.153" "3" "2" "2" "2" "781" "81.9" "5.26" "5.38" "2" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6670" "ENSG00000172845" "SP3" "A0AVL9; B4E2B7; hsa:6670; Q02447; Q69B26; Q69B27; Q8TD56; Q8WWU4; Q9BQR1" "Selenium metabolism and selenoproteins; MECP2 and associated Rett syndrome; Non-genomic actions of 1,25 dihydroxyvitamin D3; Sudden infant death syndrome (SIDS) susceptibility pathways" "SUMOylation of transcription factors" "5" "0" "1.191" "0.828" "1.450" "1.113" "0.688" "1.098" "0.897" "0.690" "0.879" "837.6" "997.9" "693.5" "1214.9" "932.0" "576.3" "919.7" "751.1" "577.9" "736.6" "" "" "" "" "" "" "" "" "" "" "784.8" "825.8" "643.8" "939.1" "794.4" "550.6" "840.3" "666.9" "577.9" "709.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2611611163430655941" "False" "High" "IsMasterProtein" "P01106" "Myc proto-oncogene protein OS=Homo sapiens OX=9606 GN=MYC PE=1 SV=2" "0.000" "False" "5.152" "4" "2" "2" "2" "454" "50.5" "5.43" "6.54" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf01056, Pf02344" "4609" "ENSG00000136997" "MYC" "A0A024R9L7; A0A087WUS5; A8WFE7; H0YBT0; hsa:4609; P01106; P01107; Q14026" "IL-5 signaling pathway; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Integrated cancer pathway; Thyroid stimulating hormone (TSH) signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Neural crest differentiation; Thymic stromal lymphopoietin (TSLP) signaling pathway; Metastatic brain tumor; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Gastric cancer network 2; Spinal cord injury; Retinoblastoma gene in cancer; Apoptosis; Polycystic kidney disease pathway; Aryl hydrocarbon receptor pathway; Interleukin-1 (IL-1) structural pathway; Mammary gland development pathway - Embryonic development (Stage 1 of 4); Mammary gland development pathway - Puberty (Stage 2 of 4); Mammary gland development pathway - Involution (Stage 4 of 4); Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Bladder cancer; Ectoderm differentiation; Vitamin D receptor pathway; PPAR-alpha pathway; Nuclear receptors meta-pathway; let-7 inhibition of ES cell reprogramming; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; Imatinib and chronic myeloid leukemia; Hepatitis C and hepatocellular carcinoma; Wnt/beta-catenin signaling pathway in leukemia; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; G1 to S cell cycle control; Hippo-Merlin signaling dysregulation; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; IL-2 signaling pathway; 3q29 copy number variation syndrome; MAPK pathway in congenital thyroid cancer; 7q11.23 copy number variation syndrome; Pleural mesothelioma; Interactions of natural killer cells in pancreatic cancer; Orexin receptor pathway; CCL18 signaling pathway; GDNF signaling; Warburg effect modulated by deubiquitinating enzymes and their substrates; Neurogenesis regulation in the olfactory epithelium; Acute myeloid leukemia; Pathophysiological roles of DUX4 in FSHD1; 5q35 copy number variation; Notch signaling pathway; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)" "MAPK6/MAPK4 signaling; Ub-specific processing proteases; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Signaling by ALK; Estrogen-dependent gene expression; Interleukin-4 and Interleukin-13 signaling; NOTCH1 Intracellular Domain Regulates Transcription; Regulation of NFE2L2 gene expression; Transcriptional regulation of granulopoiesis; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Binding of TCF/LEF:CTNNB1 to target gene promoters; Cyclin A:Cdk2-associated events at S phase entry; TFAP2 (AP-2) family regulates transcription of cell cycle factors; RUNX3 regulates WNT signaling" "91" "0" "0.999" "1.053" "1.010" "0.985" "0.959" "0.855" "0.928" "0.866" "0.856" "81.7" "81.5" "86.0" "82.5" "80.4" "78.3" "69.8" "75.8" "70.7" "69.9" "" "" "" "" "" "" "" "" "" "" "76.5" "67.5" "79.8" "63.8" "68.5" "74.8" "63.8" "67.3" "70.7" "67.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7497019614434814723" "False" "High" "IsMasterProtein" "Q9NQH7" "Xaa-Pro aminopeptidase 3 OS=Homo sapiens OX=9606 GN=XPNPEP3 PE=1 SV=1" "0.000" "False" "5.151" "3" "2" "12" "1" "507" "57.0" "6.83" "30.54" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00557, Pf05195" "63929" "ENSG00000196236" "XPNPEP3" "B2R9G1; B7Z790; B7Z7B2; hsa:63929; Q6I9V9; Q8NDA6; Q9BV27; Q9BVH0; Q9NQH7" "Ciliary landscape; Ciliopathies" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7563735417890983721" "False" "High" "IsMasterProtein" "P41208" "Centrin-2 OS=Homo sapiens OX=9606 GN=CETN2 PE=1 SV=1" "0.000" "False" "5.146" "15" "2" "2" "2" "172" "19.7" "5.00" "5.43" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf13499" "1069" "ENSG00000147400; ENSG00000292191" "CETN2" "B2R4T4; hsa:1069; P41208; Q53XW1" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Recruitment of NuMA to mitotic centrosomes; SUMOylation of DNA damage response and repair proteins; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "13" "0" "1.156" "1.085" "1.124" "1.144" "1.057" "1.019" "1.049" "1.070" "1.052" "129.7" "150.0" "140.7" "145.8" "148.5" "137.1" "132.2" "136.1" "138.8" "136.5" "" "" "" "" "" "" "" "" "" "" "121.6" "124.1" "130.6" "112.7" "126.5" "131.0" "120.8" "120.8" "138.8" "131.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6643122719444543200" "False" "High" "IsMasterProtein" "Q96CB8" "Integrator complex subunit 12 OS=Homo sapiens OX=9606 GN=INTS12 PE=1 SV=1" "0.000" "False" "5.136" "4" "2" "3" "2" "462" "48.8" "9.69" "8.77" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00628" "57117" "ENSG00000138785" "INTS12" "B2RC48; hsa:57117; Q3B6Z3; Q96CB8; Q9HD71" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "0.997" "1.047" "1.154" "1.054" "1.067" "1.003" "0.996" "1.031" "1.027" "129.6" "129.3" "135.7" "149.6" "136.6" "138.3" "130.0" "129.1" "133.7" "133.1" "" "" "" "" "" "" "" "" "" "" "121.5" "107.0" "126.0" "115.7" "116.4" "132.2" "118.8" "114.6" "133.7" "128.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5046480723636324863" "False" "High" "IsMasterProtein" "Q9Y314" "Nitric oxide synthase-interacting protein OS=Homo sapiens OX=9606 GN=NOSIP PE=1 SV=1" "0.000" "False" "5.133" "6" "2" "3" "2" "301" "33.2" "8.82" "4.70" "2" "other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf15906" "51070" "ENSG00000142546" "NOSIP" "Q96FD2; Q9Y314" "" "NOSIP mediated eNOS trafficking" "1" "0" "0.938" "1.097" "0.960" "1.053" "1.181" "1.048" "1.130" "1.035" "1.089" "299.5" "280.8" "328.6" "287.5" "315.2" "353.8" "314.0" "338.5" "310.0" "326.2" "" "" "" "" "" "" "" "" "" "" "280.6" "232.4" "305.0" "222.3" "268.7" "338.0" "286.9" "300.5" "310.0" "314.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7308252133513090836" "False" "High" "IsMasterProtein" "O14907" "Tax1-binding protein 3 OS=Homo sapiens OX=9606 GN=TAX1BP3 PE=1 SV=2" "0.000" "False" "5.131" "19" "2" "3" "2" "124" "13.7" "8.48" "7.96" "2" "cell-cell signaling;protein metabolism;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00595" "30851" "ENSG00000213977" "TAX1BP3" "B2RD53; D3DTJ6; hsa:30851; O14907; Q7LCQ4" "" "RHO GTPases Activate Rhotekin and Rhophilins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5177948975941419372" "False" "High" "IsMasterProtein" "Q9BRR9" "Rho GTPase-activating protein 9 OS=Homo sapiens OX=9606 GN=ARHGAP9 PE=1 SV=2" "0.000" "False" "5.125" "2" "2" "2" "1" "750" "83.2" "8.34" "5.62" "2" "signal transduction;other biological processes" "non-structural extracellular;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00169, Pf00620" "64333" "ENSG00000123329" "ARHGAP9" "B4DVI3; E9PDX9; hsa:64333; Q8NAF3; Q8TCJ3; Q8WYR0; Q96EZ2; Q96S74; Q9BRR9" "" "RHOA GTPase cycle; Neutrophil degranulation; CDC42 GTPase cycle; RAC1 GTPase cycle" "4" "0" "0.964" "1.016" "1.032" "1.033" "0.956" "1.009" "0.946" "0.968" "0.996" "262.0" "252.5" "266.2" "270.2" "270.7" "250.5" "264.4" "247.9" "253.7" "261.0" "" "" "" "" "" "" "" "" "" "" "245.5" "208.9" "247.1" "208.9" "230.7" "239.4" "241.6" "220.1" "253.7" "251.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1273704181858751884" "False" "High" "IsMasterProtein" "Q8N0X4" "Citramalyl-CoA lyase, mitochondrial OS=Homo sapiens OX=9606 GN=CLYBL PE=1 SV=2" "0.000" "False" "5.107" "5" "2" "2" "2" "340" "37.3" "8.73" "6.36" "2" "cell organization and biogenesis;other biological processes" "mitochondrion" "other molecular function" "Pf03328" "171425" "ENSG00000125246" "CLYBL" "hsa:171425; Q5W0F7; Q8N0X4; Q8TDH8" "" "" "0" "0" "1.169" "1.128" "1.236" "1.136" "1.113" "1.074" "1.086" "1.220" "1.036" "182.6" "213.4" "206.0" "225.6" "207.4" "203.3" "196.1" "198.3" "222.7" "189.2" "" "" "" "" "" "" "" "" "" "" "171.1" "176.6" "191.3" "174.4" "176.8" "194.2" "179.2" "176.1" "222.7" "182.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2291665734159650582" "False" "High" "IsMasterProtein" "P62310" "U6 snRNA-associated Sm-like protein LSm3 OS=Homo sapiens OX=9606 GN=LSM3 PE=1 SV=2" "0.000" "False" "5.106" "20" "2" "3" "2" "102" "11.8" "4.70" "7.72" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "27258" "ENSG00000170860" "LSM3" "hsa:27258; P62310; Q6IAH0; Q9Y4Z1" "" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3241887692250600056" "False" "High" "IsMasterProtein" "Q15149" "Plectin OS=Homo sapiens OX=9606 GN=PLEC PE=1 SV=3" "0.000" "False" "5.103" "1" "3" "3" "3" "4684" "531.5" "5.96" "7.06" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00681, Pf03501, Pf17902, Pf18373, Pf21019, Pf21020, Pf21097" "5339" "ENSG00000178209" "PLEC" "hsa:5339; Q15148; Q15149; Q16640; Q6S376; Q6S377; Q6S378; Q6S379; Q6S380; Q6S381; Q6S382; Q6S383" "Envelope proteins and their potential roles in EDMD physiopathology" "Assembly of collagen fibrils and other multimeric structures; Caspase-mediated cleavage of cytoskeletal proteins; Type I hemidesmosome assembly" "4" "0" "1.028" "1.091" "1.518" "1.597" "1.276" "1.842" "1.649" "2.067" "1.442" "68.2" "70.1" "74.4" "103.4" "108.8" "87.0" "125.6" "112.4" "140.9" "98.3" "" "" "" "" "" "" "" "" "" "" "63.9" "58.0" "69.0" "80.0" "92.8" "83.1" "114.7" "99.8" "140.9" "94.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4624493070796375817" "False" "High" "IsMasterProtein" "Q7Z7H8" "Large ribosomal subunit protein uL10m OS=Homo sapiens OX=9606 GN=MRPL10 PE=1 SV=3" "0.000" "False" "5.097" "6" "2" "2" "2" "261" "29.3" "9.58" "4.29" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00466" "124995" "ENSG00000159111" "MRPL10" "A6NGJ4; hsa:124995; Q7Z7H8; Q96B80; Q96Q55" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.004" "1.043" "1.094" "1.053" "1.080" "1.047" "1.016" "1.004" "0.964" "410.3" "412.1" "428.0" "448.9" "432.1" "443.1" "429.4" "416.8" "411.8" "395.4" "" "" "" "" "" "" "" "" "" "" "384.4" "341.0" "397.3" "347.0" "368.3" "423.3" "392.3" "370.0" "411.8" "380.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5096502141000675032" "False" "High" "IsMasterProtein" "Q8TBB5" "Kelch domain-containing protein 4 OS=Homo sapiens OX=9606 GN=KLHDC4 PE=1 SV=1" "0.000" "False" "5.090" "5" "2" "2" "2" "520" "57.9" "5.72" "4.89" "2" "" "" "" "Pf13415, Pf13418" "54758" "ENSG00000104731" "KLHDC4" "D3DUN3; D3DUN4; D3DUN5; hsa:54758; Q8TBB5; Q96F29; Q9BVN3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8619472182958520531" "False" "High" "IsMasterProtein" "P61960" "Ubiquitin-fold modifier 1 OS=Homo sapiens OX=9606 GN=UFM1 PE=1 SV=1" "0.000" "False" "5.089" "27" "2" "3" "2" "85" "9.1" "9.31" "7.86" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "" "Pf03671" "51569" "ENSG00000120686" "UFM1" "hsa:51569; P61960; Q14346; Q5VXS0; Q6IAG6; Q9CPX2; Q9NZF2" "" "" "0" "0" "1.269" "1.028" "1.070" "0.944" "0.981" "1.101" "1.128" "1.016" "0.953" "184.0" "233.5" "189.2" "197.0" "173.8" "180.6" "202.6" "207.7" "186.9" "175.4" "" "" "" "" "" "" "" "" "" "" "172.5" "193.2" "175.6" "152.3" "148.1" "172.5" "185.2" "184.4" "186.9" "168.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7173592296681882204" "False" "High" "IsMasterProtein" "Q15651" "High mobility group nucleosome-binding domain-containing protein 3 OS=Homo sapiens OX=9606 GN=HMGN3 PE=1 SV=2" "0.000" "False" "5.088" "17" "2" "2" "2" "99" "10.7" "9.66" "6.26" "2" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "9324" "ENSG00000118418" "HMGN3" "B2RD37; hsa:9324; Q15651; Q5HYD3; Q7RTT0; Q969M5; Q9BZT7" "" "" "0" "0" "1.021" "1.072" "0.985" "0.877" "0.905" "1.106" "0.922" "0.927" "0.944" "418.7" "427.3" "448.8" "412.4" "367.3" "378.8" "463.1" "386.2" "388.1" "395.4" "" "" "" "" "" "" "" "" "" "" "392.3" "353.6" "416.7" "318.8" "313.0" "361.9" "423.1" "342.9" "388.1" "380.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "504093738677667823" "False" "High" "IsMasterProtein" "O14867" "Transcription regulator protein BACH1 OS=Homo sapiens OX=9606 GN=BACH1 PE=1 SV=2" "0.000" "False" "5.087" "2" "2" "2" "2" "736" "81.9" "5.05" "6.06" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651, Pf03131" "571" "ENSG00000156273" "BACH1" "hsa:571; O14867; O43285; Q6ICU0" "Integrated cancer pathway; Ferroptosis" "Heme signaling; Regulation of HMOX1 expression and activity; Regulation of BACH1 activity; NFE2L2 regulating anti-oxidant/detoxification enzymes" "6" "0" "1.246" "0.992" "1.009" "1.116" "1.163" "1.101" "1.052" "1.144" "1.136" "289.2" "360.4" "287.0" "291.8" "322.8" "336.3" "318.4" "304.2" "331.0" "328.6" "" "" "" "" "" "" "" "" "" "" "271.0" "298.2" "266.5" "225.6" "275.1" "321.3" "291.0" "270.1" "331.0" "316.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2086395098636375665" "False" "High" "IsMasterProtein" "Q96Q89" "Kinesin-like protein KIF20B OS=Homo sapiens OX=9606 GN=KIF20B PE=1 SV=3" "0.000" "False" "5.079" "1" "2" "2" "2" "1820" "210.5" "5.67" "3.86" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "9585" "ENSG00000138182" "KIF20B" "A8MXM7; hsa:9585; O43277; Q09471; Q2KQ73; Q32NE1; Q561V3; Q58EX8; Q5T9M8; Q5T9M9; Q5T9N0; Q5T9N1; Q7KZ68; Q7Z5E0; Q7Z5E1; Q7Z6M9; Q86X82; Q96Q89; Q9H3R8; Q9H6Q9; Q9H755; Q9NTC1; Q9UFR5" "Gastric cancer network 1" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "3" "0" "1.178" "1.083" "1.117" "1.092" "1.051" "1.108" "1.144" "1.010" "1.138" "207.8" "244.7" "225.0" "232.1" "226.9" "218.3" "230.3" "237.6" "209.8" "236.4" "" "" "" "" "" "" "" "" "" "" "194.7" "202.5" "208.9" "179.4" "193.4" "208.5" "210.4" "211.0" "209.8" "227.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9115814355814308870" "False" "High" "IsMasterProtein" "P05164" "Myeloperoxidase OS=Homo sapiens OX=9606 GN=MPO PE=1 SV=1" "0.000" "False" "5.076" "3" "2" "2" "2" "745" "83.8" "8.97" "5.40" "2" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03098" "4353" "ENSG00000005381" "MPO" "A1L4B8; hsa:4353; P05164; Q14862; Q4PJH5; Q9UCL7" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Benzene metabolism; Acute myeloid leukemia; Affected pathways in Duchenne muscular dystrophy" "Neutrophil degranulation; Events associated with phagocytolytic activity of PMN cells" "8" "0" "1.186" "0.889" "1.329" "1.132" "1.126" "1.199" "1.089" "1.101" "0.945" "59.3" "70.3" "52.7" "78.8" "67.1" "66.8" "71.1" "64.6" "65.3" "56.0" "" "" "" "" "" "" "" "" "" "" "55.6" "58.2" "48.9" "60.9" "57.2" "63.8" "65.0" "57.3" "65.3" "53.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "284975731923891311" "False" "High" "IsMasterProtein" "Q14644" "Ras GTPase-activating protein 3 OS=Homo sapiens OX=9606 GN=RASA3 PE=1 SV=3" "0.000" "False" "5.075" "2" "2" "2" "1" "834" "95.6" "7.15" "4.84" "2" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "transporter activity;enzyme regulator activity;other molecular function" "Pf00168, Pf00169, Pf00616, Pf00779" "22821" "ENSG00000185989; ENSG00000280477" "RASA3" "A6NL15; F8W6X8; hsa:22821; Q14644; Q8IUY2" "MAPK cascade; Ras signaling; IL-18 signaling pathway" "Regulation of RAS by GAPs" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5713044218766232811" "False" "High" "IsMasterProtein" "Q9NXR7" "BRISC and BRCA1-A complex member 2 OS=Homo sapiens OX=9606 GN=BABAM2 PE=1 SV=2" "0.000" "False" "5.068" "5" "2" "2" "2" "383" "43.5" "5.81" "5.70" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf06113" "9577" "ENSG00000158019" "BABAM2" "A8K4X1; D6W562; D6W563; hsa:9577; Q13880; Q4ZFX8; Q53SD0; Q969X9; Q96P06; Q9NXR7" "5q35 copy number variation" "Processing of DNA double-strand break ends; Nonhomologous End-Joining (NHEJ); Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; G2/M DNA damage checkpoint" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1418350428187629844" "False" "High" "IsMasterProtein" "O43678" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 OS=Homo sapiens OX=9606 GN=NDUFA2 PE=1 SV=3" "0.000" "False" "5.068" "19" "2" "2" "2" "99" "10.9" "9.57" "4.76" "2" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "other membranes;mitochondrion" "transporter activity" "Pf05047" "4695" "ENSG00000131495" "NDUFA2" "D6RJD6; hsa:4695; O43678; Q6IAY8" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis; Mitochondrial protein degradation" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4186240485352530352" "False" "High" "IsMasterProtein" "Q96SI1" "BTB/POZ domain-containing protein KCTD15 OS=Homo sapiens OX=9606 GN=KCTD15 PE=1 SV=1" "0.000" "False" "5.065" "6" "2" "3" "2" "283" "31.9" "7.44" "7.85" "2" "cell organization and biogenesis" "nucleus" "other molecular function" "Pf02214, Pf20871" "79047" "ENSG00000153885" "KCTD15" "A8K600; hsa:79047; Q96SI1; Q9BVI6" "" "Negative regulation of activity of TFAP2 (AP-2) family transcription factors" "1" "0" "0.946" "1.007" "1.155" "1.036" "1.152" "1.046" "1.066" "1.066" "1.033" "232.2" "219.6" "233.7" "268.3" "240.5" "267.4" "242.8" "247.4" "247.6" "239.8" "" "" "" "" "" "" "" "" "" "" "217.5" "181.7" "217.0" "207.4" "205.0" "255.5" "221.9" "219.7" "247.6" "230.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6232139059952850141" "False" "High" "IsMasterProtein" "O94874" "E3 UFM1-protein ligase 1 OS=Homo sapiens OX=9606 GN=UFL1 PE=1 SV=2" "0.000" "False" "5.058" "2" "2" "2" "2" "794" "89.5" "6.79" "4.86" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf09743" "23376" "ENSG00000014123" "UFL1" "A0PJ53; B4DJ57; C0H5X5; hsa:23376; O94874; Q8N765; Q9NTQ0" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.137" "0.945" "1.284" "1.024" "0.982" "1.210" "0.979" "0.947" "0.942" "158.3" "180.0" "149.5" "203.3" "162.1" "155.5" "191.6" "154.9" "149.9" "149.1" "" "" "" "" "" "" "" "" "" "" "148.3" "148.9" "138.8" "157.2" "138.2" "148.5" "175.1" "137.6" "149.9" "143.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5352136499893616615" "False" "High" "IsMasterProtein" "O95219" "Sorting nexin-4 OS=Homo sapiens OX=9606 GN=SNX4 PE=1 SV=1" "0.000" "False" "5.050" "4" "2" "2" "2" "450" "51.9" "5.99" "5.22" "2" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787" "8723" "ENSG00000114520" "SNX4" "B3KMH0; B4DQV4; D3DNA3; hsa:8723; O95219" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-115181160460478952" "False" "High" "IsMasterProtein" "P35754" "Glutaredoxin-1 OS=Homo sapiens OX=9606 GN=GLRX PE=1 SV=2" "0.000" "False" "5.042" "10" "1" "2" "1" "106" "11.8" "8.09" "5.09" "1" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00462" "2745" "ENSG00000173221" "GLRX" "B2R4L2; hsa:2745; P35754; Q3KQS1; Q6ICT1" "One-carbon metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "1.029" "1.122" "1.108" "1.085" "1.205" "1.251" "1.308" "1.357" "1.060" "53.1" "54.6" "59.6" "58.8" "57.6" "64.0" "66.4" "69.4" "72.0" "56.2" "" "" "" "" "" "" "" "" "" "" "49.7" "45.2" "55.3" "45.5" "49.1" "61.1" "60.7" "61.6" "72.0" "54.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8590031244663879657" "False" "High" "IsMasterProtein" "P47224" "Guanine nucleotide exchange factor MSS4 OS=Homo sapiens OX=9606 GN=RABIF PE=1 SV=2" "0.000" "False" "5.028" "16" "2" "2" "2" "123" "13.8" "5.52" "3.65" "2" "cell organization and biogenesis;transport;signal transduction" "other membranes;cytosol" "enzyme regulator activity;other molecular function" "Pf04421" "5877" "ENSG00000183155" "RABIF" "B2R4P4; hsa:5877; P47224; Q92992" "Retinoblastoma gene in cancer" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1870443060398404245" "False" "High" "IsMasterProtein" "Q9H0N5" "Pterin-4-alpha-carbinolamine dehydratase 2 OS=Homo sapiens OX=9606 GN=PCBD2 PE=1 SV=4" "0.000" "False" "5.027" "12" "2" "2" "2" "130" "14.4" "9.11" "7.05" "2" "other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01329" "84105" "ENSG00000132570" "PCBD2" "hsa:84105; Q8TD40; Q9H0N5" "" "" "0" "0" "1.056" "0.929" "0.960" "1.013" "1.026" "1.012" "1.056" "1.022" "0.917" "314.5" "332.1" "292.1" "302.1" "318.7" "322.6" "318.4" "332.2" "321.6" "288.3" "" "" "" "" "" "" "" "" "" "" "294.7" "274.8" "271.2" "233.5" "271.6" "308.2" "290.9" "295.0" "321.6" "277.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-404480449398085068" "False" "High" "IsMasterProtein" "P51809" "Vesicle-associated membrane protein 7 OS=Homo sapiens OX=9606 GN=VAMP7 PE=1 SV=3" "0.000" "False" "5.019" "7" "2" "2" "2" "220" "24.9" "8.60" "6.17" "2" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957, Pf13774" "6845" "ENSG00000124333; ENSG00000292366" "VAMP7" "hsa:6845; P51809; Q53GY7; Q7Z409; Q9H4A7" "" "Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Interleukin-12 signaling" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3302594298258381880" "False" "High" "IsMasterProtein" "Q9H825" "tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial OS=Homo sapiens OX=9606 GN=METTL8 PE=1 SV=2" "0.000" "False" "5.008" "5" "2" "2" "2" "291" "33.4" "6.95" "6.18" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf08242" "79828" "ENSG00000123600" "METTL8" "hsa:79828; Q53TM9; Q53TQ0; Q9H825" "" "" "0" "0" "1.198" "1.041" "1.172" "1.174" "1.328" "1.267" "0.862" "1.124" "1.168" "66.1" "79.2" "68.8" "77.5" "77.7" "87.8" "83.7" "57.0" "74.3" "77.2" "" "" "" "" "" "" "" "" "" "" "61.9" "65.5" "63.9" "59.9" "66.2" "83.9" "76.5" "50.6" "74.3" "74.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4827521234037792457" "False" "High" "IsMasterProtein" "Q9NUS5" "AP-5 complex subunit sigma-1 OS=Homo sapiens OX=9606 GN=AP5S1 PE=1 SV=1" "0.000" "False" "5.003" "10" "2" "2" "2" "200" "22.5" "6.87" "5.19" "2" "DNA metabolism;stress response;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle" "" "Pf15001" "55317" "ENSG00000125843" "AP5S1" "B3KSD0; D3DVY7; hsa:55317; Q9NUS5" "" "" "0" "0" "0.977" "0.966" "1.052" "1.023" "1.052" "0.987" "0.964" "1.073" "1.022" "161.7" "157.9" "156.1" "170.0" "165.5" "170.1" "159.6" "155.9" "173.5" "165.3" "" "" "" "" "" "" "" "" "" "" "151.5" "130.7" "145.0" "131.4" "141.0" "162.5" "145.8" "138.4" "173.5" "159.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5312560653861073020" "False" "High" "IsMasterProtein" "P82932" "Small ribosomal subunit protein bS6m OS=Homo sapiens OX=9606 GN=MRPS6 PE=1 SV=3" "0.000" "False" "4.999" "22" "3" "3" "3" "125" "14.2" "9.26" "6.30" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf01250" "64968" "ENSG00000243927" "MRPS6" "B2R573; hsa:64968; P82932; Q96Q64; Q9BSK8; Q9BW89" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.909" "0.898" "0.943" "0.971" "1.041" "0.900" "0.943" "0.861" "0.933" "414.8" "377.1" "372.5" "391.1" "402.7" "431.6" "373.1" "391.1" "357.0" "387.0" "" "" "" "" "" "" "" "" "" "" "388.6" "312.0" "345.8" "302.4" "343.2" "412.4" "340.9" "347.3" "357.0" "372.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3788247885213699411" "False" "High" "IsMasterProtein" "P04233" "HLA class II histocompatibility antigen gamma chain OS=Homo sapiens OX=9606 GN=CD74 PE=1 SV=3" "0.000" "False" "4.993" "7" "2" "2" "2" "296" "33.5" "8.44" "5.38" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00086, Pf08831, Pf09307" "972" "ENSG00000019582" "CD74" "A8K7R1; B4DNE8; D3DQG3; D3DQG4; hsa:972; P04233; Q14597; Q29832; Q5U0J8; Q8SNA0; Q8WLP6" "Macrophage markers" "MHC class II antigen presentation; Cell surface interactions at the vascular wall" "3" "0" "1.214" "0.934" "1.364" "1.157" "1.094" "0.964" "1.142" "1.114" "1.053" "80.6" "97.9" "75.3" "110.0" "93.3" "88.2" "77.7" "92.1" "89.9" "84.9" "" "" "" "" "" "" "" "" "" "" "75.6" "81.0" "69.9" "85.0" "79.5" "84.3" "71.0" "81.7" "89.9" "81.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6501697818920195355" "False" "High" "IsMasterProtein" "Q9Y3B9" "RRP15-like protein OS=Homo sapiens OX=9606 GN=RRP15 PE=1 SV=2" "0.000" "False" "4.988" "5" "2" "2" "2" "282" "31.5" "5.52" "6.17" "2" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "" "Pf07890" "51018" "ENSG00000067533" "RRP15" "hsa:51018; Q9Y3B9" "" "" "0" "0" "0.972" "0.982" "0.950" "1.014" "0.940" "1.145" "1.178" "1.047" "0.982" "716.6" "696.4" "703.4" "681.1" "727.0" "673.9" "820.2" "843.9" "750.0" "703.4" "" "" "" "" "" "" "" "" "" "" "671.5" "576.3" "653.0" "526.5" "619.7" "643.9" "749.5" "749.3" "750.0" "677.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6449078799256658420" "False" "High" "IsMasterProtein" "Q53FA7" "Quinone oxidoreductase PIG3 OS=Homo sapiens OX=9606 GN=TP53I3 PE=1 SV=2" "0.000" "False" "4.982" "5" "2" "2" "2" "332" "35.5" "7.17" "5.22" "2" "other metabolic processes" "cytosol" "other molecular function" "Pf00107, Pf08240" "9540" "ENSG00000115129" "TP53I3" "D6W533; hsa:9540; O14679; O14685; Q38G78; Q53FA7; Q6JLE7; Q9BWB8" "p53 transcriptional gene network; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "3" "0" "1.151" "0.966" "1.179" "1.068" "1.086" "1.005" "1.003" "1.086" "1.064" "84.3" "97.1" "81.4" "99.4" "90.0" "91.6" "84.7" "84.6" "91.6" "89.7" "" "" "" "" "" "" "" "" "" "" "79.0" "80.3" "75.6" "76.8" "76.7" "87.5" "77.4" "75.1" "91.6" "86.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8134550695814129755" "False" "High" "IsMasterProtein" "P30519" "Heme oxygenase 2 OS=Homo sapiens OX=9606 GN=HMOX2 PE=1 SV=2" "0.000" "False" "4.976" "5" "2" "2" "2" "316" "36.0" "5.41" "6.10" "2" "other metabolic processes;stress response" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf01126" "3163" "ENSG00000103415; ENSG00000277424" "HMOX2" "A8MT35; D3DUD5; hsa:3163; I3L430; O60605; P30519" "" "RHOA GTPase cycle; Neutrophil degranulation; Cytoprotection by HMOX1; Iron uptake and transport; Heme degradation" "5" "0" "0.934" "0.948" "1.056" "1.117" "1.167" "1.494" "1.552" "1.491" "1.167" "304.4" "284.2" "288.4" "321.3" "340.0" "355.1" "454.8" "472.5" "453.9" "355.3" "" "" "" "" "" "" "" "" "" "" "285.2" "235.2" "267.8" "248.4" "289.8" "339.3" "415.6" "419.6" "453.9" "342.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5295951375825513477" "False" "High" "IsMasterProtein" "Q14186" "Transcription factor Dp-1 OS=Homo sapiens OX=9606 GN=TFDP1 PE=1 SV=1" "0.000" "False" "4.971" "11" "2" "2" "2" "410" "45.0" "6.05" "3.03" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02319, Pf08781" "7027" "ENSG00000198176" "TFDP1" "B4DLQ9; hsa:7027; Q14186; Q5JSB4; Q8IZL5" "Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; G1 to S cell cycle control; DYRK1A involvement regarding cell proliferation in brain development" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Oxidative Stress Induced Senescence; Transcriptional Regulation by E2F6; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Activation of PUMA and translocation to mitochondria; Transcriptional regulation of granulopoiesis; G1/S-Specific Transcription; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Activation of NOXA and translocation to mitochondria; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "23" "0" "0.817" "1.078" "0.924" "1.038" "0.919" "1.072" "0.739" "0.904" "0.992" "13.3" "10.8" "14.3" "12.3" "13.8" "12.2" "14.2" "9.8" "12.0" "13.2" "" "" "" "" "" "" "" "" "" "" "12.4" "9.0" "13.3" "9.5" "11.7" "11.7" "13.0" "8.7" "12.0" "12.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7148094604996287167" "False" "High" "IsMasterProtein" "Q9Y3E1" "Hepatoma-derived growth factor-related protein 3 OS=Homo sapiens OX=9606 GN=HDGFL3 PE=1 SV=1" "0.000" "False" "4.969" "8" "2" "5" "1" "203" "22.6" "7.99" "12.99" "2" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;nucleus" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf00855" "50810" "ENSG00000166503" "HDGFL3" "hsa:50810; Q9Y3E1" "" "" "0" "0" "1.140" "0.969" "1.094" "1.339" "1.119" "1.149" "1.112" "1.057" "1.123" "167.2" "190.6" "162.0" "183.0" "223.9" "187.1" "192.1" "185.9" "176.7" "187.7" "" "" "" "" "" "" "" "" "" "" "156.6" "157.7" "150.4" "141.4" "190.9" "178.7" "175.5" "165.0" "176.7" "180.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4487628495145980375" "False" "High" "IsMasterProtein" "Q13425" "Beta-2-syntrophin OS=Homo sapiens OX=9606 GN=SNTB2 PE=1 SV=1" "0.000" "False" "4.961" "3" "2" "2" "1" "540" "57.9" "8.82" "5.52" "2" "" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00595, Pf18012" "6645" "ENSG00000168807" "SNTB2" "hsa:6645; Q13425; Q9BY09" "" "" "0" "0" "1.241" "1.093" "1.306" "0.987" "0.895" "1.148" "1.014" "1.055" "0.996" "47.4" "58.8" "51.8" "61.9" "46.8" "42.4" "54.4" "48.1" "50.0" "47.2" "" "" "" "" "" "" "" "" "" "" "44.4" "48.7" "48.1" "47.9" "39.9" "40.5" "49.7" "42.7" "50.0" "45.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824590419555307181" "False" "High" "IsMasterProtein" "P63165" "Small ubiquitin-related modifier 1 OS=Homo sapiens OX=9606 GN=SUMO1 PE=1 SV=1" "0.000" "False" "4.958" "21" "3" "4" "3" "101" "11.6" "5.52" "7.19" "3" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf11976" "7341" "ENSG00000116030" "SUMO1" "A8MUS8; B2R4I5; hsa:7341; P55856; P63165; Q6FGG0; Q6NZ62; Q93068" "Androgen receptor signaling pathway; TP53 network; TGF-beta signaling pathway; Exercise-induced circadian regulation" "PKR-mediated signaling; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Regulation of IFNG signaling; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Formation of Incision Complex in GG-NER; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; SUMOylation of nuclear envelope proteins; Maturation of nucleoprotein; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "27" "0" "1.079" "0.985" "0.971" "0.986" "1.038" "1.051" "1.075" "1.018" "0.972" "272.5" "294.2" "268.4" "264.7" "268.8" "282.9" "286.5" "293.1" "277.5" "265.0" "" "" "" "" "" "" "" "" "" "" "255.4" "243.4" "249.2" "204.6" "229.1" "270.3" "261.8" "260.2" "277.5" "255.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3427861429656696180" "False" "High" "IsMasterProtein" "O95197" "Reticulon-3 OS=Homo sapiens OX=9606 GN=RTN3 PE=1 SV=2" "0.000" "False" "4.957" "2" "2" "3" "2" "1032" "112.5" "4.96" "8.33" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component" "" "Pf02453" "10313" "ENSG00000133318" "RTN3" "B3KQS2; B7Z308; B7Z4M0; F5H774; hsa:10313; O95197; Q147U9; Q496K2; Q53GN3; Q59EP0; Q5UEP2; Q6T930; Q7RTM7; Q7RTM8; Q7RTN3" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "Synaptic adhesion-like molecules" "3" "0" "1.044" "1.105" "0.961" "1.083" "1.089" "0.976" "0.985" "0.886" "1.016" "388.9" "406.0" "429.7" "373.6" "421.2" "423.6" "379.7" "383.2" "344.7" "395.1" "" "" "" "" "" "" "" "" "" "" "364.4" "336.0" "398.9" "288.8" "359.0" "404.8" "346.9" "340.2" "344.7" "380.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1239746035430338710" "False" "High" "IsMasterProtein" "Q2T9J0" "Peroxisomal leader peptide-processing protease OS=Homo sapiens OX=9606 GN=TYSND1 PE=1 SV=3" "0.000" "False" "4.951" "3" "2" "2" "2" "566" "59.3" "6.20" "5.96" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf13365" "219743" "ENSG00000156521" "TYSND1" "hsa:219743; Q2T9J0; Q5SQT4; Q5SQU1; Q8N6H2; Q96AR5" "" "TYSND1 cleaves peroxisomal proteins" "2" "0" "0.987" "0.978" "1.076" "1.006" "1.016" "0.920" "0.927" "0.954" "0.909" "209.5" "206.8" "204.9" "225.4" "210.8" "212.8" "192.7" "194.3" "199.9" "190.4" "" "" "" "" "" "" "" "" "" "" "196.3" "171.1" "190.2" "174.3" "179.7" "203.4" "176.1" "172.5" "199.9" "183.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4095542091731415933" "False" "High" "IsMasterProtein" "Q9HA47" "Uridine-cytidine kinase 1 OS=Homo sapiens OX=9606 GN=UCK1 PE=1 SV=1" "0.000" "False" "4.951" "6" "2" "3" "1" "277" "31.4" "7.30" "5.97" "2" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00485" "83549" "ENSG00000130717" "UCK1" "hsa:83549; Q5JT09; Q5JT10; Q5JT12; Q5JT13; Q6IA74; Q96BJ0; Q9HA47" "Fluoropyrimidine activity; Pyrimidine metabolism; IL-18 signaling pathway" "Pyrimidine salvage" "4" "0" "0.944" "0.868" "1.080" "0.984" "0.859" "1.056" "0.924" "0.944" "1.196" "209.4" "197.5" "181.8" "226.0" "206.1" "179.7" "221.0" "193.4" "197.6" "250.4" "" "" "" "" "" "" "" "" "" "" "196.2" "163.5" "168.8" "174.7" "175.6" "171.7" "201.9" "171.7" "197.6" "241.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2016868097673482949" "False" "High" "IsMasterProtein" "Q9GZY6" "Linker for activation of T-cells family member 2 OS=Homo sapiens OX=9606 GN=LAT2 PE=1 SV=1" "0.000" "False" "4.949" "9" "2" "2" "2" "243" "26.5" "4.78" "3.26" "2" "transport;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf15703" "7462" "ENSG00000086730" "LAT2" "A6NFK6; A8K209; A8K4F1; D3DXF9; hsa:7462; Q9BXX8; Q9GZY6; Q9NZY9" "B cell receptor signaling pathway; 7q11.23 copy number variation syndrome" "Role of LAT2/NTAL/LAB on calcium mobilization" "3" "0" "1.024" "0.964" "0.994" "1.012" "0.963" "0.903" "0.881" "0.863" "0.889" "432.9" "443.2" "417.3" "430.5" "438.0" "417.1" "391.0" "381.3" "373.5" "385.0" "" "" "" "" "" "" "" "" "" "" "405.6" "366.7" "387.4" "332.8" "373.3" "398.5" "357.2" "338.6" "373.5" "370.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "307320246962858459" "False" "High" "IsMasterProtein" "Q6UWZ7" "BRCA1-A complex subunit Abraxas 1 OS=Homo sapiens OX=9606 GN=ABRAXAS1 PE=1 SV=2" "0.000" "False" "4.933" "4" "2" "2" "2" "409" "46.6" "7.05" "5.88" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "cytoskeletal activity;other molecular function" "Pf21125" "84142" "ENSG00000163322" "ABRAXAS1" "A5JJ07; hsa:84142; Q6UWZ7; Q9H8I1; Q9H9N4" "5q35 copy number variation" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "6" "0" "0.970" "0.975" "0.987" "0.988" "0.955" "1.009" "0.904" "1.034" "0.988" "249.6" "242.2" "243.3" "246.4" "246.6" "238.4" "251.8" "225.5" "258.0" "246.6" "" "" "" "" "" "" "" "" "" "" "233.8" "200.4" "225.8" "190.4" "210.2" "227.8" "230.1" "200.2" "258.0" "237.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7234885358333908901" "False" "High" "IsMasterProtein" "O75915" "PRA1 family protein 3 OS=Homo sapiens OX=9606 GN=ARL6IP5 PE=1 SV=1" "0.000" "False" "4.930" "10" "2" "2" "2" "188" "21.6" "9.77" "5.67" "2" "other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi" "" "Pf03208" "10550" "ENSG00000144746" "ARL6IP5" "B2R6V5; hsa:10550; O75915; Q53ES3; Q5KU08" "" "Glutamate Neurotransmitter Release Cycle" "1" "0" "0.972" "1.003" "0.939" "1.036" "1.017" "0.866" "0.987" "1.004" "1.047" "233.1" "226.7" "233.8" "219.0" "241.4" "237.0" "201.8" "230.1" "234.0" "244.0" "" "" "" "" "" "" "" "" "" "" "218.4" "187.6" "217.1" "169.3" "205.8" "226.5" "184.4" "204.3" "234.0" "234.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3627252899551957156" "False" "High" "IsMasterProtein" "Q9NSC5" "Homer protein homolog 3 OS=Homo sapiens OX=9606 GN=HOMER3 PE=1 SV=2" "0.000" "False" "4.926" "4" "2" "3" "2" "361" "39.8" "5.45" "8.01" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00568" "9454" "ENSG00000051128" "HOMER3" "B2RA10; E9PCW9; hsa:9454; O14580; O95350; Q9NSB9; Q9NSC0; Q9NSC1; Q9NSC5" "PKC-gamma calcium signaling pathway in ataxia; Cell lineage map for neuronal differentiation" "Neurexins and neuroligins" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5234927014907967079" "False" "High" "IsMasterProtein" "Q9H0S4" "Probable ATP-dependent RNA helicase DDX47 OS=Homo sapiens OX=9606 GN=DDX47 PE=1 SV=1" "0.000" "False" "4.925" "4" "2" "2" "2" "455" "50.6" "9.10" "3.01" "2" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "nucleus" "other molecular function" "Pf00270, Pf00271" "51202" "ENSG00000213782" "DDX47" "B3KXP4; G5E955; hsa:51202; Q96GM0; Q96NV8; Q9H0S4; Q9UI98" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.111" "0.997" "1.428" "1.264" "1.215" "1.220" "1.050" "1.346" "1.185" "27.4" "30.5" "27.4" "39.2" "34.7" "33.3" "33.5" "28.8" "36.9" "32.5" "" "" "" "" "" "" "" "" "" "" "25.7" "25.2" "25.4" "30.3" "29.6" "31.9" "30.6" "25.6" "36.9" "31.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1655251497259487415" "False" "High" "IsMasterProtein" "Q9BV38" "WD repeat-containing protein 18 OS=Homo sapiens OX=9606 GN=WDR18 PE=1 SV=2" "0.000" "False" "4.925" "4" "2" "2" "2" "432" "47.4" "6.70" "5.34" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf00400, Pf14077" "57418" "ENSG00000065268" "WDR18" "hsa:57418; O60390; Q9BV38; Q9BWR2" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.084" "1.116" "0.998" "1.031" "1.026" "0.975" "0.980" "1.039" "1.046" "456.3" "494.6" "509.2" "455.5" "470.3" "468.1" "444.7" "447.3" "474.1" "477.3" "" "" "" "" "" "" "" "" "" "" "427.6" "409.2" "472.7" "352.1" "400.9" "447.2" "406.3" "397.1" "474.1" "459.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "117675378851989584" "False" "High" "IsMasterProtein" "P56270" "Myc-associated zinc finger protein OS=Homo sapiens OX=9606 GN=MAZ PE=1 SV=1" "0.000" "False" "4.925" "5" "3" "3" "3" "477" "48.6" "8.95" "2.62" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13894" "4150" "ENSG00000103495" "MAZ" "A8QJL9; C6G496; G5E927; H3BQD6; hsa:4150; P56270; Q15703; Q8NFN7; Q99443" "16p11.2 proximal deletion syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways" "" "2" "0" "1.074" "0.940" "0.995" "1.035" "0.978" "0.910" "1.110" "0.961" "0.963" "59.3" "63.7" "55.8" "59.0" "61.4" "58.0" "54.0" "65.8" "57.0" "57.1" "" "" "" "" "" "" "" "" "" "" "55.6" "52.7" "51.8" "45.6" "52.3" "55.4" "49.3" "58.5" "57.0" "55.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1075701088619798442" "False" "High" "IsMasterProtein" "Q96BZ8" "Leukocyte receptor cluster member 1 OS=Homo sapiens OX=9606 GN=LENG1 PE=1 SV=2" "0.000" "False" "4.921" "6" "2" "2" "2" "264" "30.5" "9.80" "6.83" "2" "" "nucleus" "" "Pf10197" "79165" "ENSG00000105617; ENSG00000275935; ENSG00000276628; ENSG00000276774; ENSG00000276959; ENSG00000277457; ENSG00000277808; ENSG00000278257; ENSG00000278426; ENSG00000278516" "LENG1" "hsa:79165; Q96BZ8; Q9HCU7" "" "mRNA Splicing - Major Pathway" "1" "0" "0.973" "1.030" "1.073" "1.082" "1.034" "1.043" "1.117" "1.086" "1.033" "465.3" "452.8" "479.3" "499.1" "503.5" "481.3" "485.3" "519.6" "505.5" "480.6" "" "" "" "" "" "" "" "" "" "" "436.0" "374.7" "444.9" "385.8" "429.2" "459.8" "443.4" "461.4" "505.5" "462.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9041443353459398324" "False" "High" "IsMasterProtein" "Q8N9N7" "Leucine-rich repeat-containing protein 57 OS=Homo sapiens OX=9606 GN=LRRC57 PE=1 SV=1" "0.000" "False" "4.921" "8" "2" "2" "2" "239" "26.7" "8.43" "5.64" "2" "" "other membranes" "" "Pf13855" "255252" "ENSG00000180979" "LRRC57" "hsa:255252; Q7Z2Z6; Q8N1T6; Q8N9N7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "578593252033224214" "False" "High" "IsMasterProtein" "O94818" "Nucleolar protein 4 OS=Homo sapiens OX=9606 GN=NOL4 PE=1 SV=2" "0.000" "False" "4.918" "3" "2" "2" "2" "638" "71.3" "5.62" "4.20" "2" "" "nucleus" "nucleic acid binding activity" "" "8715" "ENSG00000101746" "NOL4" "B4DSQ0; B7Z3Z7; F5H1E3; hsa:8715; O94818; Q6IBS2; Q9BWF1" "" "" "0" "0" "1.069" "1.050" "1.178" "1.106" "1.070" "1.058" "1.051" "1.001" "1.050" "188.9" "202.0" "198.4" "222.6" "209.0" "202.2" "199.9" "198.5" "189.2" "198.3" "" "" "" "" "" "" "" "" "" "" "177.0" "167.2" "184.2" "172.1" "178.1" "193.2" "182.7" "176.3" "189.2" "191.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "274015145252682130" "False" "High" "IsMasterProtein" "Q9UH62" "Armadillo repeat-containing X-linked protein 3 OS=Homo sapiens OX=9606 GN=ARMCX3 PE=1 SV=1" "0.000" "False" "4.917" "5" "2" "3" "2" "379" "42.5" "8.37" "2.60" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "" "Pf04826" "51566" "ENSG00000102401" "ARMCX3" "hsa:51566; Q53HC6; Q7LCF5; Q9NPE4; Q9UH62" "" "RAC2 GTPase cycle" "1" "0" "1.112" "1.066" "1.212" "1.121" "1.066" "1.173" "1.196" "1.106" "1.187" "136.2" "151.5" "145.1" "165.1" "152.6" "145.1" "159.7" "162.9" "150.6" "161.7" "" "" "" "" "" "" "" "" "" "" "127.6" "125.3" "134.8" "127.7" "130.1" "138.7" "145.9" "144.6" "150.6" "155.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4353551603118957972" "False" "High" "IsMasterProtein" "P34949" "Mannose-6-phosphate isomerase OS=Homo sapiens OX=9606 GN=MPI PE=1 SV=2" "0.000" "False" "4.913" "5" "2" "2" "2" "423" "46.6" "5.95" "6.77" "2" "other metabolic processes" "cytosol" "other molecular function" "Pf01238, Pf20511, Pf20512" "4351" "ENSG00000178802" "MPI" "A8K8K9; hsa:4351; P34949; Q96AB0" "N-glycan biosynthesis" "Synthesis of GDP-mannose; Defective MPI causes MPI-CDG" "3" "0" "0.990" "0.941" "0.850" "1.015" "1.051" "0.823" "0.903" "1.042" "0.994" "185.2" "183.3" "174.2" "157.4" "188.0" "194.6" "152.4" "167.2" "192.9" "184.1" "" "" "" "" "" "" "" "" "" "" "173.5" "151.7" "161.7" "121.7" "160.2" "185.9" "139.2" "148.4" "192.9" "177.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4463882674882175167" "False" "High" "IsMasterProtein" "Q5NDL2" "EGF domain-specific O-linked N-acetylglucosamine transferase OS=Homo sapiens OX=9606 GN=EOGT PE=1 SV=1" "0.000" "False" "4.911" "3" "2" "2" "2" "527" "62.0" "7.05" "6.20" "2" "protein metabolism;other metabolic processes" "ER/Golgi" "other molecular function" "Pf04577" "285203" "ENSG00000163378" "EOGT" "A8K2U1; B4DFH5; hsa:285203; L7X1M5; Q5NDL2; Q6MZY0; Q6P985; Q6ZTV0" "Genetic causes of porto-sinusoidal vascular disease" "" "1" "0" "1.139" "1.009" "1.227" "1.127" "1.141" "1.153" "1.055" "0.965" "1.044" "229.2" "261.0" "231.4" "281.2" "258.4" "261.6" "264.3" "241.9" "221.2" "239.2" "" "" "" "" "" "" "" "" "" "" "214.8" "216.0" "214.8" "217.4" "220.3" "249.9" "241.5" "214.8" "221.2" "230.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5891546535660205639" "False" "High" "IsMasterProtein" "Q6P1X6" "UPF0598 protein C8orf82 OS=Homo sapiens OX=9606 GN=C8orf82 PE=1 SV=2" "0.000" "False" "4.907" "7" "2" "2" "2" "216" "23.9" "9.14" "4.56" "2" "" "" "" "Pf14956" "414919" "ENSG00000213563" "C8orf82" "hsa:414919; Q6GMR2; Q6P1X6; Q6P2Q7" "" "" "0" "0" "1.000" "0.974" "1.144" "1.083" "1.173" "1.010" "1.116" "1.071" "1.042" "214.4" "214.4" "208.9" "245.3" "232.2" "251.5" "216.6" "239.4" "229.8" "223.5" "" "" "" "" "" "" "" "" "" "" "200.9" "177.4" "193.9" "189.6" "197.9" "240.3" "198.0" "212.5" "229.8" "215.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7890622308646159318" "False" "High" "IsMasterProtein" "Q93083" "Metallothionein-1L OS=Homo sapiens OX=9606 GN=MT1L PE=1 SV=1" "0.000" "False" "4.905" "33" "2" "3" "2" "61" "6.1" "7.96" "3.75" "2" "stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00131" "" "" "MT1L" "Q93083" "" "" "0" "0" "1.096" "1.044" "1.046" "1.040" "1.064" "0.593" "0.728" "1.018" "0.977" "592.9" "649.6" "618.8" "620.1" "616.4" "630.6" "351.8" "431.6" "603.7" "579.4" "" "" "" "" "" "" "" "" "" "" "555.5" "537.6" "574.5" "479.4" "525.4" "602.5" "321.5" "383.2" "603.7" "557.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6167412320153067815" "False" "High" "IsMasterProtein" "P35613" "Basigin OS=Homo sapiens OX=9606 GN=BSG PE=1 SV=2" "0.000" "False" "4.903" "4" "2" "2" "2" "385" "42.2" "5.66" "2.64" "2" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13927" "682" "ENSG00000172270" "BSG" "A6NJW1; D3YLG5; hsa:682; P35613; Q7Z796; Q8IZL7" "Matrix metalloproteinases; VEGFA-VEGFR2 signaling; IL-18 signaling pathway" "Degradation of the extracellular matrix; Integrin cell surface interactions; Pyruvate metabolism; Aspirin ADME; Basigin interactions; Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5177131133338512997" "False" "High" "IsMasterProtein" "Q8IXM3" "Large ribosomal subunit protein mL41 OS=Homo sapiens OX=9606 GN=MRPL41 PE=1 SV=1" "0.000" "False" "4.899" "16" "2" "3" "2" "137" "15.4" "9.57" "7.70" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;other cell component" "other molecular function" "Pf09809" "64975" "ENSG00000182154" "MRPL41" "hsa:64975; Q8IXM3; Q96Q49" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.117" "1.095" "0.889" "1.041" "1.161" "0.946" "1.047" "1.051" "1.064" "130.6" "145.9" "143.1" "116.1" "136.1" "151.6" "123.6" "136.7" "137.3" "139.1" "" "" "" "" "" "" "" "" "" "" "122.4" "120.7" "132.8" "89.8" "116.0" "144.9" "112.9" "121.4" "137.3" "133.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6133561671554163995" "False" "High" "IsMasterProtein" "P43378" "Tyrosine-protein phosphatase non-receptor type 9 OS=Homo sapiens OX=9606 GN=PTPN9 PE=1 SV=1" "0.000" "False" "4.877" "3" "2" "3" "2" "593" "68.0" "8.02" "8.49" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00102, Pf00650" "5780" "ENSG00000169410" "PTPN9" "hsa:5780; P43378; Q53XR9" "VEGFA-VEGFR2 signaling" "Interleukin-37 signaling" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8151909637929937359" "False" "High" "IsMasterProtein" "Q14554" "Protein disulfide-isomerase A5 OS=Homo sapiens OX=9606 GN=PDIA5 PE=1 SV=1" "0.000" "False" "4.876" "3" "2" "2" "2" "519" "59.6" "7.91" "5.56" "2" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00085" "10954" "ENSG00000065485" "PDIA5" "D3DN95; hsa:10954; Q14554; Q9BV43" "" "XBP1(S) activates chaperone genes" "1" "0" "1.075" "1.147" "1.166" "1.115" "1.053" "1.131" "1.054" "0.970" "1.065" "168.2" "180.7" "192.9" "196.1" "187.5" "177.1" "190.1" "177.3" "163.1" "179.1" "" "" "" "" "" "" "" "" "" "" "157.6" "149.5" "179.1" "151.6" "159.8" "169.2" "173.7" "157.5" "163.1" "172.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2753337708247017490" "False" "High" "IsMasterProtein" "Q9H0R6" "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial OS=Homo sapiens OX=9606 GN=QRSL1 PE=1 SV=2" "0.000" "False" "4.869" "3" "2" "3" "2" "528" "57.4" "5.68" "7.34" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf01425" "55278" "ENSG00000130348" "QRSL1" "hsa:55278; Q5VWJ4; Q9H0R6; Q9HA60; Q9NV19" "" "" "0" "0" "0.917" "0.835" "0.957" "0.997" "0.979" "0.863" "0.885" "0.943" "0.986" "133.7" "122.6" "111.7" "128.0" "133.3" "130.9" "115.3" "118.3" "126.0" "131.9" "" "" "" "" "" "" "" "" "" "" "125.3" "101.5" "103.7" "98.9" "113.6" "125.1" "105.4" "105.0" "126.0" "127.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5970229024696725622" "False" "High" "IsMasterProtein" "O96020" "G1/S-specific cyclin-E2 OS=Homo sapiens OX=9606 GN=CCNE2 PE=1 SV=1" "0.000" "False" "4.868" "4" "2" "3" "2" "404" "46.7" "7.83" "6.20" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00134, Pf02984" "9134" "ENSG00000175305" "CCNE2" "hsa:9134; O95439; O96020" "miRNA regulation of DNA damage response; Cell cycle; Parkinson's disease pathway; Retinoblastoma gene in cancer; PI3K-Akt signaling pathway; Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; NF1 copy number variation syndrome ; DNA damage response" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Association of TriC/CCT with target proteins during biosynthesis; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); DNA Damage/Telomere Stress Induced Senescence; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response" "22" "0" "1.005" "0.963" "1.137" "1.052" "1.055" "1.095" "1.021" "1.051" "1.021" "596.7" "599.8" "574.4" "678.2" "627.9" "629.3" "653.6" "609.3" "627.3" "609.5" "" "" "" "" "" "" "" "" "" "" "559.1" "496.3" "533.3" "524.3" "535.2" "601.3" "597.2" "541.0" "627.3" "586.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5274992111862833065" "False" "High" "IsMasterProtein" "Q8IXJ6" "NAD-dependent protein deacetylase sirtuin-2 OS=Homo sapiens OX=9606 GN=SIRT2 PE=1 SV=2" "0.000" "False" "4.859" "5" "2" "3" "2" "389" "43.2" "5.36" "8.93" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf02146" "22933" "ENSG00000068903; ENSG00000283100" "SIRT2" "A8K3V1; B2RB45; hsa:22933; O95889; Q8IXJ6; Q924Y7; Q9P0G8; Q9UNT0; Q9Y6E9; U5TP13" "NAD+ metabolism; NAD+ biosynthetic pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; HDAC6 interactions in the central nervous system" "Initiation of Nuclear Envelope (NE) Reformation" "5" "0" "1.220" "1.166" "1.329" "1.202" "1.009" "1.273" "1.030" "0.983" "1.040" "47.9" "58.4" "55.8" "63.6" "57.5" "48.3" "60.9" "49.3" "47.1" "49.8" "" "" "" "" "" "" "" "" "" "" "44.8" "48.3" "51.8" "49.2" "49.0" "46.1" "55.7" "43.8" "47.1" "47.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2292330841191308535" "False" "High" "IsMasterProtein" "O75420" "GRB10-interacting GYF protein 1 OS=Homo sapiens OX=9606 GN=GIGYF1 PE=1 SV=2" "0.000" "False" "4.853" "2" "2" "2" "2" "1035" "114.5" "5.39" "5.46" "2" "signal transduction" "cytosol;other cell component" "" "Pf02213" "" "ENSG00000146830" "GIGYF1" "O75420; Q6Y7W7; Q8WZ38" "" "" "0" "0" "1.113" "0.977" "1.068" "0.972" "1.121" "1.083" "0.952" "0.836" "0.937" "93.8" "104.4" "91.7" "100.2" "91.2" "105.2" "101.6" "89.3" "78.5" "87.8" "" "" "" "" "" "" "" "" "" "" "87.9" "86.4" "85.1" "77.5" "77.7" "100.5" "92.8" "79.3" "78.5" "84.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9091705123101461009" "False" "High" "IsMasterProtein" "P99999" "Cytochrome c OS=Homo sapiens OX=9606 GN=CYCS PE=1 SV=2" "0.000" "False" "4.853" "14" "2" "4" "2" "105" "11.7" "9.57" "11.27" "2" "other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00034" "54205" "ENSG00000172115" "CYCS" "A4D166; B2R4I1; hsa:54205; P00001; P99999; Q6NUR2; Q6NX69; Q96BV4" "miRNA regulation of DNA damage response; Apoptosis modulation and signaling; Alzheimer's disease and miRNA effects; AGE/RAGE pathway; Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling; Oxidative damage response; NO/cGMP/PKG mediated neuroprotection; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Pleural mesothelioma; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response" "Respiratory electron transport; Detoxification of Reactive Oxygen Species; Transcriptional activation of mitochondrial biogenesis; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria; Pyroptosis" "36" "0" "1.032" "1.016" "0.979" "1.020" "1.028" "0.883" "1.111" "0.990" "0.988" "256.9" "265.2" "260.9" "251.6" "262.1" "264.1" "226.9" "285.4" "254.3" "253.7" "" "" "" "" "" "" "" "" "" "" "240.7" "219.4" "242.2" "194.5" "223.4" "252.3" "207.3" "253.4" "254.3" "244.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8834965082719872925" "False" "High" "IsMasterProtein" "Q96EQ0" "Small glutamine-rich tetratricopeptide repeat-containing protein beta OS=Homo sapiens OX=9606 GN=SGTB PE=1 SV=1" "0.000" "False" "4.852" "7" "2" "2" "2" "304" "33.4" "4.92" "4.84" "2" "cell organization and biogenesis;other biological processes" "other membranes;cytosol" "other molecular function" "Pf00515, Pf13414, Pf16546" "54557" "ENSG00000197860" "SGTB" "hsa:54557; Q96EQ0" "" "" "0" "0" "1.098" "1.007" "1.084" "1.065" "1.017" "1.080" "1.144" "0.982" "1.019" "146.1" "160.3" "147.1" "158.3" "155.5" "148.5" "157.8" "167.1" "143.5" "148.8" "" "" "" "" "" "" "" "" "" "" "136.9" "132.7" "136.6" "122.4" "132.5" "141.9" "144.2" "148.4" "143.5" "143.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5139072581549819915" "False" "High" "IsMasterProtein" "Q8IWV8" "E3 ubiquitin-protein ligase UBR2 OS=Homo sapiens OX=9606 GN=UBR2 PE=1 SV=1" "0.000" "False" "4.850" "1" "2" "2" "2" "1755" "200.4" "6.24" "3.01" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02207, Pf02617, Pf18995" "23304" "ENSG00000024048" "UBR2" "O15057; Q4VXK2; Q5TFH6; Q6P2I2; Q6ZUD0; Q8IWV8" "Male infertility; Primary ovarian insufficiency" "Antigen processing: Ubiquitination & Proteasome degradation" "3" "0" "1.241" "1.016" "1.398" "1.218" "1.067" "1.200" "0.939" "1.029" "1.059" "82.6" "102.4" "83.8" "115.4" "100.6" "88.1" "99.0" "77.5" "85.0" "87.4" "" "" "" "" "" "" "" "" "" "" "77.4" "84.8" "77.8" "89.2" "85.7" "84.2" "90.5" "68.8" "85.0" "84.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8359859415185382416" "False" "High" "IsMasterProtein" "O75575" "DNA-directed RNA polymerase III subunit RPC9 OS=Homo sapiens OX=9606 GN=CRCP PE=1 SV=1" "0.000" "False" "4.849" "10" "2" "3" "2" "148" "16.9" "5.39" "6.67" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03874" "27297" "ENSG00000241258" "CRCP" "A8MUZ4; A8MW23; B2R4H4; B4E198; hsa:27297; O75575; Q3KRA3; Q5HYF1; Q8IXL4" "Myometrial relaxation and contraction pathways" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "8" "0" "1.132" "0.949" "1.023" "0.972" "1.035" "0.895" "0.976" "0.900" "0.975" "444.0" "502.5" "421.3" "454.3" "431.6" "459.7" "397.3" "433.4" "399.4" "433.0" "" "" "" "" "" "" "" "" "" "" "416.0" "415.8" "391.1" "351.2" "367.9" "439.2" "363.0" "384.8" "399.4" "416.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-201446485204969397" "False" "High" "IsMasterProtein" "P56282" "DNA polymerase epsilon subunit 2 OS=Homo sapiens OX=9606 GN=POLE2 PE=1 SV=2" "0.000" "False" "4.849" "4" "2" "2" "2" "527" "59.5" "6.35" "5.34" "2" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04042, Pf12213" "5427" "ENSG00000100479" "POLE2" "A0AV55; A4FU92; A4LBB7; A6NH58; B4DDE6; O43560; P56282" "Retinoblastoma gene in cancer; Pyrimidine metabolism; G1 to S cell cycle control; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Activation of the pre-replicative complex; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; DNA replication initiation; Gap-filling DNA repair synthesis and ligation in GG-NER" "19" "0" "1.071" "1.015" "1.068" "1.014" "1.076" "0.990" "1.022" "0.948" "1.046" "248.1" "265.8" "252.0" "265.1" "251.5" "267.1" "245.7" "253.6" "235.2" "259.7" "" "" "" "" "" "" "" "" "" "" "232.5" "220.0" "233.9" "204.9" "214.4" "255.2" "224.5" "225.2" "235.2" "250.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3088066192462104792" "False" "High" "IsMasterProtein" "O15534" "Period circadian protein homolog 1 OS=Homo sapiens OX=9606 GN=PER1 PE=1 SV=2" "0.000" "False" "4.842" "1" "2" "2" "2" "1290" "136.1" "6.09" "5.67" "2" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08447, Pf12114, Pf21353" "5187" "ENSG00000179094" "PER1" "B2RPA8; B4DI49; D3DTR3; hsa:5187; O15534" "Melatonin metabolism and effects; Exercise-induced circadian regulation; Th17 cell differentiation pathway; Clock-controlled autophagy in bone metabolism; NF1 copy number variation syndrome ; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Circadian Clock" "7" "0" "1.011" "1.015" "1.133" "1.113" "1.020" "1.075" "0.933" "0.963" "1.073" "238.0" "240.6" "241.7" "269.6" "264.8" "242.7" "255.8" "222.1" "229.2" "255.5" "" "" "" "" "" "" "" "" "" "" "223.0" "199.1" "224.3" "208.4" "225.7" "231.9" "233.7" "197.2" "229.2" "246.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2891424664368030590" "False" "High" "IsMasterProtein" "Q8N6T3" "ADP-ribosylation factor GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=ARFGAP1 PE=1 SV=2" "0.000" "False" "4.823" "4" "2" "2" "2" "406" "44.6" "5.66" "4.86" "2" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "55738" "ENSG00000101199" "ARFGAP1" "B7Z3U0; B7Z8H8; B7ZBI3; E1P5I9; E7EV62; hsa:55738; Q6PK71; Q8N6T3; Q96KC4; Q96T02; Q9NSU3; Q9NVF6; Q9UIL0" "IL-18 signaling pathway" "XBP1(S) activates chaperone genes; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; Clathrin-mediated endocytosis" "5" "0" "1.119" "1.028" "1.103" "1.147" "1.063" "0.987" "1.046" "0.961" "1.060" "647.2" "724.2" "665.5" "713.6" "742.3" "688.2" "638.6" "677.0" "622.0" "686.3" "" "" "" "" "" "" "" "" "" "" "606.4" "599.3" "617.8" "551.7" "632.7" "657.5" "583.5" "601.1" "622.0" "660.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3125530162626484972" "False" "High" "IsMasterProtein" "Q9Y2L9" "Leucine-rich repeat and calponin homology domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LRCH1 PE=1 SV=3" "0.000" "False" "4.800" "2" "2" "3" "1" "728" "80.8" "5.94" "5.76" "2" "other biological processes" "other cell component" "" "Pf00307, Pf13855" "23143" "ENSG00000136141" "LRCH1" "B7ZLL5; F8W6F0; hsa:23143; Q17R43; Q2KHR1; Q5TBU9; Q7Z5F6; Q7Z5F7; Q9Y2L9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1759740052719989179" "False" "High" "IsMasterProtein" "O14561" "Acyl carrier protein, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAB1 PE=1 SV=3" "0.000" "False" "4.790" "15" "2" "3" "2" "156" "17.4" "4.93" "5.08" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;nucleus" "translation activity;other molecular function" "Pf00550" "4706" "ENSG00000004779" "NDUFAB1" "B2R4M1; O14561; Q9UNV1" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Glyoxylate metabolism and glycine degradation; Mitochondrial Fatty Acid Beta-Oxidation; Complex I biogenesis" "7" "0" "0.930" "0.965" "0.941" "1.004" "1.078" "1.010" "1.078" "1.035" "1.015" "244.4" "227.2" "235.9" "230.0" "245.5" "263.5" "246.9" "263.6" "253.0" "248.0" "" "" "" "" "" "" "" "" "" "" "229.0" "188.0" "219.0" "177.8" "209.2" "251.8" "225.6" "234.0" "253.0" "238.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "354118340354877787" "False" "High" "IsMasterProtein" "P56962" "Syntaxin-17 OS=Homo sapiens OX=9606 GN=STX17 PE=1 SV=2" "0.000" "False" "4.781" "6" "2" "3" "2" "302" "33.4" "6.57" "4.75" "2" "cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "" "55014" "ENSG00000136874" "STX17" "hsa:55014; P56962; Q4VXC2" "" "COPII-mediated vesicle transport" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-585008616192458607" "False" "High" "IsMasterProtein" "Q9H6E5" "Speckle targeted PIP5K1A-regulated poly(A) polymerase OS=Homo sapiens OX=9606 GN=TUT1 PE=1 SV=2" "0.000" "False" "4.780" "2" "2" "2" "2" "874" "93.8" "6.16" "5.89" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf03828, Pf12874" "64852" "ENSG00000149016" "TUT1" "A1A527; A8K995; hsa:64852; Q2NL65; Q7L583; Q9H6E5; Q9H6H7" "" "" "0" "0" "1.003" "1.014" "0.963" "0.950" "1.058" "0.916" "0.904" "0.992" "1.030" "164.4" "164.9" "166.8" "158.3" "156.2" "174.0" "150.6" "148.7" "163.1" "169.4" "" "" "" "" "" "" "" "" "" "" "154.1" "136.5" "154.8" "122.4" "133.1" "166.2" "137.6" "132.0" "163.1" "163.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6714422319878504399" "False" "High" "IsMasterProtein" "O95391" "Pre-mRNA-splicing factor SLU7 OS=Homo sapiens OX=9606 GN=SLU7 PE=1 SV=2" "0.000" "False" "4.771" "4" "3" "3" "3" "586" "68.3" "7.14" "6.54" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11708" "10569" "ENSG00000164609" "SLU7" "D3DQK2; hsa:10569; O95391; Q3LUJ0; Q3LUJ1; Q6RXQ5; Q96FM9" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "4" "0" "0.920" "0.980" "1.133" "0.846" "1.063" "1.176" "1.108" "1.148" "1.140" "83.3" "76.7" "81.7" "94.4" "70.5" "88.6" "98.0" "92.3" "95.7" "95.0" "" "" "" "" "" "" "" "" "" "" "78.1" "63.5" "75.8" "73.0" "60.1" "84.7" "89.5" "82.0" "95.7" "91.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4679234799158284053" "False" "High" "IsMasterProtein" "Q8N954" "G patch domain-containing protein 11 OS=Homo sapiens OX=9606 GN=GPATCH11 PE=1 SV=4" "0.000" "False" "4.769" "6" "2" "2" "2" "285" "33.3" "5.86" "6.14" "2" "" "other cell component" "nucleic acid binding activity" "Pf01585, Pf13821" "253635" "" "GPATCH11" "A0A0A0MSF9; A8K0D9; B7Z2G4; B8ZZ44; hsa:253635; Q8N954" "" "" "0" "0" "1.074" "0.958" "1.044" "0.955" "0.964" "0.980" "1.118" "1.099" "1.000" "266.8" "286.5" "255.7" "278.5" "254.7" "257.3" "261.4" "298.4" "293.4" "266.8" "" "" "" "" "" "" "" "" "" "" "250.0" "237.1" "237.4" "215.3" "217.1" "245.8" "238.9" "265.0" "293.4" "256.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3382226448836069029" "False" "High" "IsMasterProtein" "Q69YH5" "Cell division cycle-associated protein 2 OS=Homo sapiens OX=9606 GN=CDCA2 PE=1 SV=2" "0.000" "False" "4.768" "2" "2" "2" "2" "1023" "112.6" "8.40" "4.35" "2" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "" "Pf15276" "157313" "ENSG00000184661" "CDCA2" "hsa:157313; Q3SX74; Q4G0W0; Q5RKN0; Q69YH5; Q69YI4; Q6P464; Q8N7C1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6964625045538099576" "False" "High" "IsMasterProtein" "Q9H6R7" "WD repeat and coiled-coil-containing protein OS=Homo sapiens OX=9606 GN=WDCP PE=1 SV=1" "0.000" "False" "4.764" "2" "2" "3" "2" "721" "79.1" "6.70" "8.64" "2" "cell organization and biogenesis" "" "other molecular function" "Pf15390" "80304" "ENSG00000163026" "WDCP" "D6W532; hsa:80304; Q8IYK0; Q9H6R7; Q9HBP5" "Mesodermal commitment pathway" "Signaling by ALK fusions and activated point mutants" "2" "0" "0.959" "0.979" "0.884" "0.940" "1.027" "0.864" "0.930" "0.991" "0.991" "673.4" "645.9" "659.0" "595.4" "632.9" "691.9" "581.5" "626.2" "667.6" "667.5" "" "" "" "" "" "" "" "" "" "" "631.0" "534.5" "611.8" "460.3" "539.5" "661.1" "531.4" "556.0" "667.6" "642.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4353457585173966729" "False" "High" "IsMasterProtein" "P84101" "Small EDRK-rich factor 2 OS=Homo sapiens OX=9606 GN=SERF2 PE=1 SV=1" "0.000" "False" "4.762" "29" "2" "2" "2" "59" "6.9" "10.45" "4.85" "2" "other biological processes" "cytosol;nucleus" "" "Pf04419" "10169" "ENSG00000140264" "SERF2" "A6NL45; B5MCG1; B9A026; hsa:10169; O75918; O88891; P84101; Q9BZH7" "" "" "0" "0" "1.147" "0.917" "1.003" "0.849" "0.905" "0.824" "0.837" "1.173" "0.999" "261.5" "300.1" "240.0" "262.3" "222.1" "236.8" "215.6" "219.0" "306.7" "261.2" "" "" "" "" "" "" "" "" "" "" "245.1" "248.3" "222.8" "202.8" "189.3" "226.2" "197.0" "194.4" "306.7" "251.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4942654517427891889" "False" "High" "IsMasterProtein" "Q9H6D7" "HAUS augmin-like complex subunit 4 OS=Homo sapiens OX=9606 GN=HAUS4 PE=1 SV=1" "0.000" "False" "4.762" "6" "2" "2" "2" "363" "42.4" "5.68" "3.31" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf14735" "54930" "ENSG00000092036" "HAUS4" "B7WP17; D3DS34; hsa:54930; Q86T15; Q86T16; Q86U43; Q9H6D7; Q9NX59" "" "Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7332918538450832394" "False" "High" "IsMasterProtein" "P18847" "Cyclic AMP-dependent transcription factor ATF-3 OS=Homo sapiens OX=9606 GN=ATF3 PE=1 SV=2" "0.000" "False" "4.761" "10" "2" "2" "2" "181" "20.6" "8.54" "6.65" "2" "other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "467" "ENSG00000162772" "ATF3" "hsa:467; P18847; Q5VTZ2; Q6ICQ9; Q7Z566; Q8WYM6" "Myometrial relaxation and contraction pathways; Photodynamic therapy-induced unfolded protein response; TGF-beta signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; IL-18 signaling pathway; Pleural mesothelioma; CCL18 signaling pathway; Hypertrophy model" "Response of EIF2AK1 (HRI) to heme deficiency; ATF4 activates genes in response to endoplasmic reticulum stress; Response of EIF2AK4 (GCN2) to amino acid deficiency" "11" "0" "0.863" "0.920" "0.995" "1.041" "1.004" "1.106" "1.329" "0.985" "1.224" "535.6" "462.0" "493.0" "533.0" "557.4" "537.8" "592.3" "711.5" "527.5" "655.3" "" "" "" "" "" "" "" "" "" "" "501.8" "382.3" "457.7" "412.0" "475.1" "513.8" "541.2" "631.7" "527.5" "631.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1635530099867829890" "False" "High" "IsMasterProtein" "Q86Y37" "CDK2-associated and cullin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CACUL1 PE=1 SV=1" "0.000" "False" "4.749" "7" "2" "2" "2" "369" "41.0" "5.19" "7.23" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf00888" "143384" "ENSG00000151893" "CACUL1" "hsa:143384; Q5XPL7; Q86Y37; Q8IY11; Q8N7S4" "" "" "0" "0" "1.159" "1.072" "1.207" "1.109" "1.086" "1.065" "1.090" "1.017" "1.136" "144.4" "167.3" "154.8" "174.4" "160.1" "156.9" "153.8" "157.4" "146.9" "164.1" "" "" "" "" "" "" "" "" "" "" "135.3" "138.5" "143.7" "134.8" "136.5" "149.9" "140.5" "139.8" "146.9" "158.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2083530276327625921" "False" "High" "IsMasterProtein" "Q9BUW7" "Bublin coiled-coil protein OS=Homo sapiens OX=9606 GN=BBLN PE=1 SV=1" "0.000" "False" "4.749" "30" "2" "2" "2" "83" "9.0" "4.22" "5.93" "2" "cell organization and biogenesis" "cytoskeleton;other cell component" "other molecular function" "Pf03670" "79095" "ENSG00000171159" "BBLN" "hsa:79095; Q5SYV8; Q9BUW7; Q9Y3F7" "" "" "0" "0" "0.966" "0.808" "1.163" "1.051" "0.878" "1.034" "1.045" "0.980" "0.990" "57.6" "55.6" "46.6" "67.0" "60.6" "50.6" "59.6" "60.2" "56.5" "57.1" "" "" "" "" "" "" "" "" "" "" "54.0" "46.0" "43.2" "51.8" "51.6" "48.3" "54.4" "53.5" "56.5" "54.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7226470696601852520" "False" "High" "IsMasterProtein" "Q9H0A8" "COMM domain-containing protein 4 OS=Homo sapiens OX=9606 GN=COMMD4 PE=1 SV=1" "0.000" "False" "4.742" "8" "2" "3" "2" "199" "21.8" "7.31" "7.68" "2" "" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf07258, Pf21672" "54939" "ENSG00000140365" "COMMD4" "B2RBN4; H3BUL2; hsa:54939; Q7L637; Q9H0A8; Q9NX43" "" "Neddylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3373935659803620703" "False" "High" "IsMasterProtein" "Q9UKY1" "Zinc fingers and homeoboxes protein 1 OS=Homo sapiens OX=9606 GN=ZHX1 PE=1 SV=1" "0.000" "False" "4.739" "2" "2" "2" "2" "873" "98.0" "6.05" "5.16" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf11569, Pf18387" "11244" "ENSG00000165156" "ZHX1" "hsa:11244; Q8IWD8; Q9UKY1" "" "" "0" "0" "0.986" "0.999" "0.958" "0.958" "1.063" "0.924" "0.931" "1.019" "1.007" "263.6" "259.9" "263.4" "252.6" "252.6" "280.3" "243.6" "245.4" "268.7" "265.4" "" "" "" "" "" "" "" "" "" "" "247.0" "215.1" "244.6" "195.3" "215.3" "267.8" "222.6" "217.9" "268.7" "255.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "918212557622448470" "False" "High" "IsMasterProtein" "Q9HAJ7" "Histone deacetylase complex subunit SAP30L OS=Homo sapiens OX=9606 GN=SAP30L PE=1 SV=1" "0.000" "False" "4.735" "9" "2" "2" "2" "183" "20.9" "9.36" "5.39" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13866, Pf13867" "79685" "ENSG00000164576" "SAP30L" "E9PAU7; E9PAY2; hsa:79685; Q9HAJ7" "" "Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression" "3" "0" "1.068" "1.041" "1.013" "1.018" "1.019" "1.010" "0.948" "0.994" "0.998" "288.4" "308.0" "300.1" "292.1" "293.5" "293.9" "291.3" "273.3" "286.6" "287.8" "" "" "" "" "" "" "" "" "" "" "270.2" "254.8" "278.6" "225.8" "250.2" "280.8" "266.2" "242.7" "286.6" "277.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6046703873344704710" "False" "High" "IsMasterProtein" "Q9H1D9" "DNA-directed RNA polymerase III subunit RPC6 OS=Homo sapiens OX=9606 GN=POLR3F PE=1 SV=1" "0.000" "False" "4.727" "6" "2" "2" "2" "316" "35.7" "6.11" "4.51" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05158" "10621" "ENSG00000132664" "POLR3F" "A8K4C7; hsa:10621; O15319; Q9H1D9" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; TAR syndrome" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "1.019" "0.933" "1.302" "0.989" "0.895" "1.318" "1.247" "0.945" "0.947" "96.1" "97.9" "89.6" "125.1" "95.0" "85.9" "126.7" "119.8" "90.8" "91.0" "" "" "" "" "" "" "" "" "" "" "90.0" "81.0" "83.2" "96.7" "81.0" "82.1" "115.7" "106.4" "90.8" "87.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6036892115816411697" "False" "High" "IsMasterProtein" "Q9H9G7" "Protein argonaute-3 OS=Homo sapiens OX=9606 GN=AGO3 PE=1 SV=2" "0.000" "False" "4.726" "2" "2" "3" "1" "860" "97.3" "9.11" "7.82" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02170, Pf02171, Pf08699, Pf16486, Pf16487, Pf16488" "192669" "ENSG00000126070" "AGO3" "B1ALI0; hsa:192669; Q5TA55; Q9H1U6; Q9H9G7" "" "Oxidative Stress Induced Senescence; MAPK6/MAPK4 signaling; Estrogen-dependent gene expression; TP53 Regulates Metabolic Genes; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Ca2+ pathway; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis; Nuclear events stimulated by ALK signaling in cancer; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "21" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4166005915453200591" "False" "High" "IsMasterProtein" "O15078" "Centrosomal protein of 290 kDa OS=Homo sapiens OX=9606 GN=CEP290 PE=1 SV=2" "0.000" "False" "4.726" "1" "3" "3" "1" "2479" "290.2" "5.95" "4.93" "3" "cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf16574" "80184" "ENSG00000198707" "CEP290" "hsa:80184; O15078; Q1PSK5; Q66GS8; Q9H2G6; Q9H6Q7; Q9H8I0" "Clear cell renal cell carcinoma pathways; Ciliary landscape; Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation" "13" "0" "0.945" "1.116" "1.220" "1.104" "1.107" "1.134" "1.096" "1.088" "1.130" "219.6" "207.5" "245.0" "267.9" "242.4" "242.9" "249.1" "240.6" "238.9" "248.1" "" "" "" "" "" "" "" "" "" "" "205.7" "171.7" "227.4" "207.1" "206.6" "232.1" "227.6" "213.6" "238.9" "238.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6591516084365101626" "False" "High" "IsMasterProtein" "Q9H5X1" "Cytosolic iron-sulfur assembly component 2A OS=Homo sapiens OX=9606 GN=CIAO2A PE=1 SV=1" "0.000" "False" "4.721" "13" "2" "3" "2" "160" "18.3" "4.88" "6.57" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01883" "84191" "ENSG00000166797" "CIAO2A" "A6NKS1; B2R5F8; B7Z8Z5; hsa:84191; Q9H5X1" "2q11.2 copy number variation syndrome" "" "1" "0" "1.072" "1.038" "1.042" "1.068" "1.060" "0.983" "1.066" "1.062" "1.107" "176.0" "188.8" "182.8" "183.5" "188.0" "186.6" "173.1" "187.7" "187.0" "194.9" "" "" "" "" "" "" "" "" "" "" "164.9" "156.2" "169.7" "141.8" "160.3" "178.2" "158.1" "166.7" "187.0" "187.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1988329424413395185" "False" "High" "IsMasterProtein" "Q8WVK7" "Spindle and kinetochore-associated protein 2 OS=Homo sapiens OX=9606 GN=SKA2 PE=1 SV=1" "0.000" "False" "4.714" "14" "2" "2" "2" "121" "14.2" "7.33" "6.56" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf16740" "348235" "ENSG00000182628" "SKA2" "A6NIL3; B3KPL3; E9PCB8; hsa:348235; Q8WVK7" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.029" "0.984" "0.964" "1.020" "0.975" "0.897" "0.913" "0.892" "0.980" "566.9" "583.2" "558.0" "546.7" "578.3" "553.0" "508.5" "517.3" "505.5" "555.4" "" "" "" "" "" "" "" "" "" "" "531.2" "482.6" "518.0" "422.7" "492.9" "528.3" "464.7" "459.3" "505.5" "534.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "660217191297362812" "False" "High" "IsMasterProtein" "P22695" "Cytochrome b-c1 complex subunit 2, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC2 PE=1 SV=3" "0.000" "False" "4.713" "3" "2" "3" "2" "453" "48.4" "8.63" "6.72" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00675, Pf05193" "7385" "ENSG00000140740" "UQCRC2" "B3KSN4; hsa:7385; P22695; Q9BQ05" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "Mitochondrial protein degradation; Respiratory electron transport" "5" "0" "1.132" "1.066" "1.006" "1.086" "1.086" "0.977" "1.012" "1.055" "1.051" "317.8" "359.7" "338.6" "319.8" "345.0" "345.0" "310.3" "321.7" "335.3" "333.9" "" "" "" "" "" "" "" "" "" "" "297.7" "297.7" "314.4" "247.2" "294.0" "329.6" "283.6" "285.6" "335.3" "321.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "717271239892975644" "False" "High" "IsMasterProtein" "Q9UK73" "Protein fem-1 homolog B OS=Homo sapiens OX=9606 GN=FEM1B PE=1 SV=1" "0.000" "False" "4.713" "4" "2" "2" "2" "627" "70.2" "6.61" "5.58" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf12796" "10116" "ENSG00000169018" "FEM1B" "hsa:10116; O43146; Q9UK73" "" "Neddylation" "1" "0" "1.106" "1.066" "1.228" "1.127" "1.005" "1.318" "1.119" "0.949" "0.938" "66.0" "73.0" "70.3" "81.1" "74.4" "66.3" "87.0" "73.9" "62.6" "61.9" "" "" "" "" "" "" "" "" "" "" "61.8" "60.4" "65.3" "62.7" "63.4" "63.4" "79.5" "65.6" "62.6" "59.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5258533483115152097" "False" "High" "IsMasterProtein" "Q53H96" "Pyrroline-5-carboxylate reductase 3 OS=Homo sapiens OX=9606 GN=PYCR3 PE=1 SV=3" "0.000" "False" "4.702" "9" "2" "2" "2" "274" "28.6" "7.72" "6.31" "2" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf03807, Pf14748" "65263" "ENSG00000104524; ENSG00000276657" "PYCR3" "B3KMB5; B4DVT6; H0Y6C3; hsa:65263; Q53H96; Q8N3N9; Q96HX4; Q9H896" "" "Glutamate and glutamine metabolism" "1" "0" "1.064" "1.025" "1.170" "1.069" "1.042" "1.116" "1.094" "1.034" "1.057" "444.8" "473.2" "456.0" "520.5" "475.4" "463.5" "496.5" "486.7" "460.1" "469.9" "" "" "" "" "" "" "" "" "" "" "416.7" "391.5" "423.3" "402.4" "405.2" "442.8" "453.7" "432.2" "460.1" "452.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "394232053154577892" "False" "High" "IsMasterProtein" "Q92530" "Proteasome inhibitor PI31 subunit OS=Homo sapiens OX=9606 GN=PSMF1 PE=1 SV=2" "0.000" "False" "4.697" "7" "2" "3" "2" "271" "29.8" "5.74" "5.95" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf08577, Pf11566" "9491" "ENSG00000125818" "PSMF1" "A0AVQ9; D3DVW3; hsa:9491; Q92530; Q9H4I1" "" "Neddylation; KEAP1-NFE2L2 pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "59" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2806048333038512589" "False" "High" "IsMasterProtein" "Q96FQ6" "Protein S100-A16 OS=Homo sapiens OX=9606 GN=S100A16 PE=1 SV=1" "0.000" "False" "4.687" "22" "2" "2" "2" "103" "11.8" "6.79" "4.85" "2" "other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf01023" "140576" "ENSG00000188643" "S100A16" "A8K439; D3DV52; hsa:140576; Q5RHS6; Q96FQ6" "" "" "0" "0" "1.097" "1.056" "0.986" "0.959" "1.020" "1.071" "1.088" "0.949" "0.973" "90.5" "99.2" "95.5" "89.2" "86.8" "92.3" "96.9" "98.5" "85.9" "88.1" "" "" "" "" "" "" "" "" "" "" "84.8" "82.1" "88.7" "69.0" "74.0" "88.2" "88.6" "87.4" "85.9" "84.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6587954621125457531" "False" "High" "IsMasterProtein" "Q9NVH6" "Trimethyllysine dioxygenase, mitochondrial OS=Homo sapiens OX=9606 GN=TMLHE PE=1 SV=1" "0.000" "False" "4.687" "5" "2" "2" "2" "421" "49.5" "7.72" "3.29" "2" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf02668, Pf06155" "55217" "ENSG00000185973" "TMLHE" "A8K6M9; B4E3R3; hsa:55217; Q5TZB5; Q6IA90; Q8TBT0; Q9NVH6" "" "Carnitine synthesis" "1" "0" "0.945" "0.980" "1.078" "1.050" "1.030" "1.000" "1.046" "1.018" "0.956" "357.2" "337.4" "350.1" "385.2" "374.9" "367.9" "357.1" "373.6" "363.7" "341.4" "" "" "" "" "" "" "" "" "" "" "334.7" "279.2" "325.0" "297.8" "319.6" "351.5" "326.3" "331.7" "363.7" "328.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "745274347307830124" "False" "High" "IsMasterProtein" "Q9BX70" "BTB/POZ domain-containing protein 2 OS=Homo sapiens OX=9606 GN=BTBD2 PE=1 SV=1" "0.000" "False" "4.680" "3" "2" "2" "1" "525" "55.9" "5.90" "4.86" "2" "developmental processes" "cytosol;other cell component" "" "Pf00651, Pf07707, Pf08005" "55643" "ENSG00000133243" "BTBD2" "hsa:55643; O60418; O75248; Q4VBZ1; Q6IAC5; Q7Z5W0; Q96SX8; Q9BX70; Q9NPS1; Q9NX81" "" "" "0" "1" "0.995" "0.948" "1.015" "1.125" "1.103" "1.062" "0.900" "0.980" "1.096" "147.3" "146.6" "139.6" "149.5" "165.7" "162.5" "156.4" "132.5" "144.4" "161.5" "" "" "" "" "" "" "" "" "" "" "138.0" "121.3" "129.6" "115.6" "141.2" "155.2" "142.9" "117.7" "144.4" "155.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3737855785058777273" "False" "High" "IsMasterProtein" "Q9NSP4" "Centromere protein M OS=Homo sapiens OX=9606 GN=CENPM PE=1 SV=1" "0.000" "False" "4.680" "12" "2" "2" "2" "180" "19.7" "7.20" "6.09" "2" "cell cycle OR cell proliferation" "cytosol;nucleus;other cell component" "" "Pf11111" "79019" "ENSG00000100162" "CENPM" "A7LM22; B1AHQ9; hsa:79019; Q6I9W3; Q9NSP4" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere" "7" "0" "1.041" "1.046" "1.066" "0.979" "0.984" "1.025" "0.971" "1.082" "1.049" "90.7" "94.4" "94.8" "96.6" "88.8" "89.3" "93.0" "88.0" "98.1" "95.1" "" "" "" "" "" "" "" "" "" "" "85.0" "78.1" "88.0" "74.7" "75.7" "85.3" "84.9" "78.2" "98.1" "91.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8789508812130398643" "False" "High" "IsMasterProtein" "Q9BTE7" "DCN1-like protein 5 OS=Homo sapiens OX=9606 GN=DCUN1D5 PE=1 SV=1" "0.000" "False" "4.673" "6" "2" "5" "1" "237" "27.5" "5.58" "11.43" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03556" "84259" "ENSG00000137692" "DCUN1D5" "hsa:84259; Q3ZTT2; Q9BTE7" "" "Neddylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4005780129157962021" "False" "High" "IsMasterProtein" "Q9BUR4" "Telomerase Cajal body protein 1 OS=Homo sapiens OX=9606 GN=WRAP53 PE=1 SV=1" "0.000" "False" "4.671" "5" "2" "2" "2" "548" "59.3" "4.58" "5.92" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "55135" "ENSG00000141499" "WRAP53" "B3KPR9; D3DTQ4; hsa:55135; Q08ET9; Q9BUR4; Q9NW09" "" "Association of TriC/CCT with target proteins during biosynthesis; Telomere Extension By Telomerase" "2" "0" "1.082" "0.990" "1.149" "1.075" "0.976" "1.255" "1.009" "0.990" "0.971" "128.4" "138.9" "127.1" "147.5" "138.0" "125.2" "161.1" "129.5" "127.1" "124.6" "" "" "" "" "" "" "" "" "" "" "120.3" "114.9" "118.0" "114.0" "117.6" "119.6" "147.2" "115.0" "127.1" "120.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1650910315331199742" "False" "High" "IsMasterProtein" "Q9NZA1" "Chloride intracellular channel protein 5 OS=Homo sapiens OX=9606 GN=CLIC5 PE=1 SV=3" "0.000" "False" "4.671" "8" "2" "2" "2" "410" "46.5" "4.82" "4.53" "2" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cell component" "transporter activity" "Pf13409, Pf13410" "53405" "ENSG00000112782" "CLIC5" "B3KUF1; hsa:53405; Q5T4Z0; Q8NBY3; Q96JT5; Q9BWZ0; Q9NZA1" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "2" "0" "1.189" "0.997" "1.408" "1.032" "1.112" "1.317" "1.083" "1.275" "1.327" "20.0" "23.7" "19.9" "28.1" "20.6" "22.2" "26.3" "21.6" "25.4" "26.5" "" "" "" "" "" "" "" "" "" "" "18.7" "19.6" "18.5" "21.7" "17.6" "21.2" "24.0" "19.2" "25.4" "25.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8271257472643545210" "False" "High" "IsMasterProtein" "Q6PCE3" "Glucose 1,6-bisphosphate synthase OS=Homo sapiens OX=9606 GN=PGM2L1 PE=1 SV=3" "0.000" "False" "4.668" "3" "2" "3" "1" "622" "70.4" "7.15" "7.89" "2" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf02878, Pf02879, Pf02880" "283209" "ENSG00000165434" "PGM2L1" "hsa:283209; Q6PCE3; Q96MQ7; Q9UIK3" "" "Glycolysis" "1" "0" "1.280" "1.135" "1.107" "1.195" "0.950" "1.280" "1.104" "1.402" "1.056" "30.5" "39.0" "34.6" "33.8" "36.4" "29.0" "39.0" "33.7" "42.8" "32.2" "" "" "" "" "" "" "" "" "" "" "28.6" "32.3" "32.1" "26.1" "31.1" "27.7" "35.7" "29.9" "42.8" "31.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "407344682093019997" "False" "High" "IsMasterProtein" "Q53GL0" "Pleckstrin homology domain-containing family O member 1 OS=Homo sapiens OX=9606 GN=PLEKHO1 PE=1 SV=2" "0.000" "False" "4.664" "6" "2" "2" "2" "409" "46.2" "8.82" "2.70" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "" "Pf00169" "51177" "ENSG00000023902" "PLEKHO1" "hsa:51177; Q336K5; Q53GL0; Q8IZ51; Q9NRV3; Q9UL48" "" "" "0" "0" "0.993" "1.003" "1.010" "1.120" "1.071" "1.118" "1.076" "1.085" "1.102" "197.7" "196.3" "198.3" "199.7" "221.3" "211.8" "221.1" "212.8" "214.5" "217.8" "" "" "" "" "" "" "" "" "" "" "185.2" "162.4" "184.1" "154.4" "188.6" "202.3" "202.0" "188.9" "214.5" "209.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4573891914704923062" "False" "High" "IsMasterProtein" "Q9BTE1" "Dynactin subunit 5 OS=Homo sapiens OX=9606 GN=DCTN5 PE=1 SV=1" "0.000" "False" "4.663" "12" "2" "2" "2" "182" "20.1" "8.02" "4.51" "2" "developmental processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf21711" "84516" "ENSG00000166847" "DCTN5" "A8K9X8; H3BN51; H3BQA4; hsa:84516; Q9BTE1" "Vasopressin-regulated water reabsorption" "COPI-mediated anterograde transport; MHC class II antigen presentation; COPI-independent Golgi-to-ER retrograde traffic; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "5" "0" "1.107" "1.179" "1.237" "1.087" "0.984" "1.100" "1.108" "1.153" "1.178" "197.8" "219.0" "233.1" "244.7" "215.0" "194.6" "217.5" "219.2" "228.1" "233.1" "" "" "" "" "" "" "" "" "" "" "185.3" "181.2" "216.4" "189.1" "183.3" "186.0" "198.8" "194.6" "228.1" "224.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7463306019950863991" "False" "High" "IsMasterProtein" "O60784" "Target of Myb1 membrane trafficking protein OS=Homo sapiens OX=9606 GN=TOM1 PE=1 SV=2" "0.000" "False" "4.660" "3" "2" "2" "2" "492" "53.8" "4.70" "5.61" "2" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00790, Pf03127" "10043" "ENSG00000100284" "TOM1" "B4DEL9; B4DNA1; hsa:10043; O60784; Q5TIJ6; Q86X74" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-375580382225270930" "False" "High" "IsMasterProtein" "Q96LI5" "CCR4-NOT transcription complex subunit 6-like OS=Homo sapiens OX=9606 GN=CNOT6L PE=1 SV=2" "0.000" "False" "4.659" "3" "2" "2" "2" "555" "63.0" "6.74" "5.27" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03372, Pf13855" "246175" "ENSG00000138767" "CNOT6L" "hsa:246175; Q96LI5; Q9UF92" "Ciliary landscape" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "4" "0" "1.012" "1.059" "1.029" "1.116" "1.189" "1.020" "1.098" "1.138" "1.148" "149.2" "151.0" "158.1" "153.6" "166.5" "177.4" "152.2" "163.8" "169.9" "171.3" "" "" "" "" "" "" "" "" "" "" "139.8" "125.0" "146.8" "118.8" "141.9" "169.5" "139.1" "145.5" "169.9" "164.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-189490632571161728" "False" "High" "IsMasterProtein" "Q9P2E3" "NFX1-type zinc finger-containing protein 1 OS=Homo sapiens OX=9606 GN=ZNFX1 PE=1 SV=2" "0.000" "False" "4.655" "1" "3" "3" "3" "1918" "220.1" "7.30" "5.53" "3" "cell organization and biogenesis;stress response;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf13086, Pf13087, Pf20173" "57169" "ENSG00000124201" "ZNFX1" "hsa:57169; Q9BQM7; Q9BQM8; Q9H8C1; Q9H9S2; Q9NUM1; Q9NWW1; Q9P2E3" "" "" "0" "0" "1.740" "1.116" "1.441" "1.357" "1.237" "1.200" "1.086" "1.200" "1.136" "179.3" "312.0" "200.1" "258.4" "243.3" "221.8" "215.2" "194.7" "215.2" "203.6" "" "" "" "" "" "" "" "" "" "" "168.0" "258.2" "185.7" "199.8" "207.4" "211.9" "196.6" "172.9" "215.2" "196.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8170052287552769839" "False" "High" "IsMasterProtein" "Q13905" "Rap guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=RAPGEF1 PE=1 SV=3" "0.000" "False" "4.655" "2" "2" "2" "2" "1077" "120.5" "5.92" "6.99" "2" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00617, Pf00618" "2889" "ENSG00000107263" "RAPGEF1" "hsa:2889; Q13905; Q5JUE4; Q68DL3; Q8IV73" "Integrin-mediated cell adhesion; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; IL-3 signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; MET in type 1 papillary renal cell carcinoma; Insulin signaling; Interferon type I signaling pathways" "RAC3 GTPase cycle; Regulation of signaling by CBL; Downstream signal transduction; Erythropoietin activates RAS; Frs2-mediated activation; MET activates RAP1 and RAC1" "17" "0" "0.977" "0.971" "0.966" "0.972" "0.981" "0.926" "0.924" "0.956" "1.004" "490.8" "479.7" "476.6" "474.3" "476.9" "481.5" "454.7" "453.6" "469.3" "492.8" "" "" "" "" "" "" "" "" "" "" "459.9" "397.0" "442.5" "366.7" "406.5" "460.0" "415.5" "402.7" "469.3" "474.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3476524128370901588" "False" "High" "IsMasterProtein" "P53634" "Dipeptidyl peptidase 1 OS=Homo sapiens OX=9606 GN=CTSC PE=1 SV=2" "0.000" "False" "4.649" "4" "2" "3" "2" "463" "51.8" "6.99" "8.22" "2" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00112, Pf08773" "1075" "ENSG00000109861" "CTSC" "A8K7V2; B5MDD5; hsa:1075; P53634; Q2HIY8; Q53G93; Q71E75; Q71E76; Q7M4N9; Q7Z3G7; Q7Z5U7; Q8WY99; Q8WYA7; Q8WYA8" "" "Neutrophil degranulation; MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER" "4" "0" "1.087" "0.982" "0.910" "0.876" "0.756" "1.133" "1.086" "1.077" "1.028" "174.9" "190.1" "171.8" "159.1" "153.3" "132.3" "198.2" "190.0" "188.4" "179.9" "" "" "" "" "" "" "" "" "" "" "163.9" "157.3" "159.5" "123.0" "130.6" "126.4" "181.1" "168.7" "188.4" "173.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6067622255201761803" "False" "High" "IsMasterProtein" "O95059" "Ribonuclease P protein subunit p14 OS=Homo sapiens OX=9606 GN=RPP14 PE=1 SV=3" "0.000" "False" "4.642" "12" "2" "2" "2" "124" "13.7" "7.75" "5.88" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01900" "11102" "ENSG00000163684" "RPP14" "O95059; Q53X97" "" "tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol" "2" "0" "1.054" "1.055" "1.205" "1.147" "1.093" "1.104" "1.118" "1.120" "1.189" "353.9" "373.0" "373.4" "426.5" "405.8" "386.7" "390.6" "395.5" "396.4" "420.7" "" "" "" "" "" "" "" "" "" "" "331.6" "308.7" "346.6" "329.7" "345.9" "369.4" "356.9" "351.2" "396.4" "405.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-567970208974842497" "False" "High" "IsMasterProtein" "P51530" "DNA replication ATP-dependent helicase/nuclease DNA2 OS=Homo sapiens OX=9606 GN=DNA2 PE=1 SV=3" "0.000" "False" "4.641" "1" "2" "3" "1" "1060" "120.3" "7.74" "8.10" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08696, Pf12705, Pf13086, Pf13087, Pf21123" "1763" "ENSG00000138346" "DNA2" "hsa:1763; P51530; Q2NKM1; Q5TC49; Q5TC50; Q6P455; Q6PI80; Q7Z6H9; Q8N346" "" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Removal of the Flap Intermediate; Removal of the Flap Intermediate from the C-strand" "16" "0" "1.099" "1.153" "1.169" "1.008" "0.994" "0.991" "0.867" "0.999" "1.126" "85.5" "94.0" "98.6" "100.0" "86.2" "85.0" "84.8" "74.1" "85.4" "96.3" "" "" "" "" "" "" "" "" "" "" "80.1" "77.8" "91.6" "77.3" "73.5" "81.2" "77.4" "65.8" "85.4" "92.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-796628633734857382" "False" "High" "IsMasterProtein" "Q13439" "Golgin subfamily A member 4 OS=Homo sapiens OX=9606 GN=GOLGA4 PE=1 SV=1" "0.000" "False" "4.636" "1" "2" "2" "2" "2230" "261.0" "5.39" "5.06" "2" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01465" "2803" "ENSG00000144674" "GOLGA4" "F8W8Q7; hsa:2803; Q13270; Q13439; Q13654; Q14436; Q59EW8" "" "Retrograde transport at the Trans-Golgi-Network; Signaling by membrane-tethered fusions of PDGFRA or PDGFRB" "2" "0" "1.137" "1.086" "1.172" "1.183" "1.069" "1.144" "1.242" "1.054" "1.047" "127.7" "145.2" "138.7" "149.7" "151.1" "136.5" "146.1" "158.6" "134.6" "133.7" "" "" "" "" "" "" "" "" "" "" "119.6" "120.2" "128.8" "115.7" "128.8" "130.4" "133.5" "140.8" "134.6" "128.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-979600656900959777" "False" "High" "IsMasterProtein" "Q9HD40" "O-phosphoseryl-tRNA(Sec) selenium transferase OS=Homo sapiens OX=9606 GN=SEPSECS PE=1 SV=2" "0.000" "False" "4.629" "5" "2" "2" "2" "501" "55.7" "8.05" "3.24" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05889" "51091" "ENSG00000109618" "SEPSECS" "A8K8W1; hsa:51091; Q0D2P3; Q17RT1; Q9HD40; Q9NXZ5; Q9UGM9; Q9Y353" "Selenium metabolism and selenoproteins" "Selenocysteine synthesis" "2" "0" "1.151" "1.153" "1.447" "1.064" "1.140" "1.198" "0.826" "0.792" "1.188" "15.2" "17.5" "17.5" "22.0" "16.2" "17.3" "18.2" "12.6" "12.0" "18.1" "" "" "" "" "" "" "" "" "" "" "14.2" "14.5" "16.3" "17.0" "13.8" "16.5" "16.6" "11.1" "12.0" "17.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5291509197618805102" "False" "High" "IsMasterProtein" "Cont_Q3SZ57" "Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1" "0.000" "True" "4.615" "2" "2" "2" "1" "610" "68.5" "6.29" "5.07" "2" "other metabolic processes;developmental processes;signal transduction" "non-structural extracellular;other cell component" "other molecular function" "Pf00273" "506011" "ENSBIXG00000005150; ENSBTAG00000017131" "AFP" "A0A4W2DDK5; bta:506011; Q3SZ57" "" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-591138811346724328" "False" "High" "IsMasterProtein" "O15055" "Period circadian protein homolog 2 OS=Homo sapiens OX=9606 GN=PER2 PE=1 SV=2" "0.000" "False" "4.606" "1" "2" "2" "2" "1255" "136.5" "6.47" "2.44" "2" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08447, Pf12114, Pf21353" "8864" "ENSG00000132326" "PER2" "A2I2P7; hsa:8864; O15055; Q4ZG49; Q6DT41; Q9UQ45" "Melatonin metabolism and effects; Exercise-induced circadian regulation; Orexin receptor pathway; 2q37 copy number variation syndrome; Acute myeloid leukemia" "Circadian Clock" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-652499996560304904" "False" "High" "IsMasterProtein" "P32969" "Large ribosomal subunit protein uL6 OS=Homo sapiens OX=9606 GN=RPL9P9 PE=1 SV=1" "0.000" "False" "4.602" "9" "2" "2" "2" "192" "21.9" "9.95" "4.89" "2" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00347" "6133" "ENSG00000163682" "RPL9; RPL9P7; RPL9P8; RPL9P9" "hsa:6133; P32969" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis" "14" "0" "1.104" "1.134" "1.073" "1.257" "1.079" "1.471" "1.471" "1.387" "1.261" "262.0" "289.1" "297.0" "281.0" "329.2" "282.8" "385.3" "385.2" "363.2" "330.5" "" "" "" "" "" "" "" "" "" "" "245.5" "239.3" "275.7" "217.2" "280.6" "270.2" "352.0" "342.1" "363.2" "318.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7855128710481582123" "False" "High" "IsMasterProtein" "P50238" "Cysteine-rich protein 1 OS=Homo sapiens OX=9606 GN=CRIP1 PE=1 SV=3" "0.000" "False" "4.596" "21" "2" "4" "2" "77" "8.5" "8.75" "11.71" "2" "stress response;developmental processes;signal transduction;other biological processes" "other cell component" "other molecular function" "Pf00412" "1396" "ENSG00000213145" "CRIP1" "H3BPI2; hsa:1396; P50238; Q13628; Q53XY7; Q96J34" "" "" "0" "0" "0.962" "0.981" "0.899" "0.904" "0.936" "0.899" "0.949" "0.857" "0.939" "500.7" "481.6" "491.4" "450.4" "452.4" "468.5" "450.0" "475.0" "429.3" "470.1" "" "" "" "" "" "" "" "" "" "" "469.2" "398.5" "456.2" "348.2" "385.7" "447.6" "411.2" "421.8" "429.3" "452.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1253953420551710594" "False" "High" "IsMasterProtein" "Q8TAA5" "GrpE protein homolog 2, mitochondrial OS=Homo sapiens OX=9606 GN=GRPEL2 PE=1 SV=1" "0.000" "False" "4.589" "7" "2" "3" "2" "225" "25.4" "7.72" "7.10" "2" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion" "other molecular function" "Pf01025" "134266" "ENSG00000164284" "GRPEL2" "B4DFA6; hsa:134266; Q49AJ6; Q8TAA5" "" "Mitochondrial protein import" "1" "0" "1.026" "0.971" "1.030" "1.066" "0.987" "1.002" "1.036" "0.947" "0.967" "372.6" "382.2" "361.8" "383.7" "397.2" "367.8" "373.4" "385.9" "352.7" "360.4" "" "" "" "" "" "" "" "" "" "" "349.2" "316.2" "335.9" "296.6" "338.6" "351.4" "341.2" "342.7" "352.7" "347.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6729288942847254867" "False" "High" "IsMasterProtein" "P42684" "Tyrosine-protein kinase ABL2 OS=Homo sapiens OX=9606 GN=ABL2 PE=1 SV=1" "0.000" "False" "4.586" "1" "2" "2" "2" "1182" "128.3" "8.07" "6.25" "2" "cell adhesion;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714, Pf08919" "27" "ENSG00000143322" "ABL2" "A0M8X0; B7UEF2; B7UEF3; B7UEF4; B7UEF5; hsa:27; P42684; Q5T0X6; Q5W0C5; Q6NZY6; Q7Z301" "Ras signaling; Acute viral myocarditis; ErbB signaling pathway" "Role of ABL in ROBO-SLIT signaling; RAC1 GTPase cycle; RAC3 GTPase cycle; Negative regulation of FLT3" "7" "0" "1.058" "1.042" "1.212" "1.186" "1.130" "1.130" "1.105" "1.093" "1.158" "305.0" "322.6" "318.0" "369.7" "361.6" "344.6" "344.7" "337.0" "333.3" "353.3" "" "" "" "" "" "" "" "" "" "" "285.8" "267.0" "295.2" "285.8" "308.2" "329.2" "315.0" "299.2" "333.3" "340.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5308881138529098641" "False" "High" "IsMasterProtein" "Q9Y244" "Proteasome maturation protein OS=Homo sapiens OX=9606 GN=POMP PE=1 SV=1" "0.000" "False" "4.579" "12" "2" "2" "2" "141" "15.8" "5.11" "4.67" "2" "cell organization and biogenesis" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf05348" "51371" "ENSG00000132963" "POMP" "A5HKJ2; D6MXU3; hsa:51371; Q9HB69; Q9Y244" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "559389685781558546" "False" "High" "IsMasterProtein" "Q8N9R8" "Protein SCAI OS=Homo sapiens OX=9606 GN=SCAI PE=1 SV=2" "0.000" "False" "4.576" "3" "2" "2" "2" "606" "70.4" "8.60" "5.16" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf12070" "286205" "ENSG00000173611" "SCAI" "hsa:286205; Q3SXZ1; Q3SXZ2; Q5T163; Q8N1I4; Q8N9R8" "" "RHO GTPases Activate Formins" "1" "0" "0.972" "1.019" "0.956" "0.943" "1.014" "1.035" "1.022" "1.064" "0.954" "180.3" "175.2" "183.6" "172.4" "169.9" "182.8" "186.6" "184.2" "191.8" "172.0" "" "" "" "" "" "" "" "" "" "" "168.9" "144.9" "170.5" "133.2" "144.9" "174.6" "170.5" "163.5" "191.8" "165.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4556564044268480545" "False" "High" "IsMasterProtein" "Q9NR19" "Acetyl-coenzyme A synthetase, cytoplasmic OS=Homo sapiens OX=9606 GN=ACSS2 PE=1 SV=1" "0.000" "False" "4.570" "3" "2" "2" "2" "701" "78.5" "6.46" "4.77" "2" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00501, Pf13193, Pf16177" "55902" "ENSG00000131069" "ACSS2" "A6NE90; hsa:55902; Q5QPH2; Q5QPH3; Q8N238; Q96EL0; Q9NQP7; Q9NR19; Q9UJ15" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Lipid metabolism pathway; Ethanol effects on histone modifications; Fluoroacetic acid toxicity; Amino acid conjugation of benzoic acid" "Transcriptional activation of mitochondrial biogenesis; Ethanol oxidation" "8" "0" "0.938" "1.015" "1.142" "0.985" "1.025" "1.101" "1.029" "1.024" "0.920" "92.7" "86.9" "94.1" "105.8" "91.3" "95.0" "102.0" "95.3" "94.8" "85.2" "" "" "" "" "" "" "" "" "" "" "86.8" "71.9" "87.3" "81.8" "77.8" "90.8" "93.2" "84.6" "94.8" "82.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2841747620534292638" "False" "High" "IsMasterProtein" "Q6ZN04" "RNA-binding protein MEX3B OS=Homo sapiens OX=9606 GN=MEX3B PE=1 SV=1" "0.000" "False" "4.560" "4" "2" "2" "1" "569" "58.8" "6.90" "2.15" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf13920" "84206" "ENSG00000183496" "MEX3B" "hsa:84206; Q4G0W1; Q6ZN04; Q8IVG2; Q9H0J0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-501406145012788137" "False" "High" "IsMasterProtein" "Q9H2K0" "Translation initiation factor IF-3, mitochondrial OS=Homo sapiens OX=9606 GN=MTIF3 PE=1 SV=4" "0.000" "False" "4.556" "6" "2" "2" "2" "278" "31.7" "9.69" "6.32" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "translation activity;nucleic acid binding activity" "Pf05198" "219402" "ENSG00000122033" "MTIF3" "hsa:219402; Q05BL8; Q5W0V0; Q86X68; Q9H2K0" "" "Mitochondrial translation initiation" "1" "0" "1.087" "0.954" "1.091" "1.088" "1.028" "1.141" "0.992" "1.027" "1.015" "390.3" "424.4" "372.2" "425.8" "424.7" "401.1" "445.5" "387.1" "400.9" "396.2" "" "" "" "" "" "" "" "" "" "" "365.7" "351.2" "345.6" "329.2" "362.0" "383.2" "407.1" "343.7" "400.9" "381.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8065453246646173554" "False" "High" "IsMasterProtein" "O15231" "Zinc finger protein 185 OS=Homo sapiens OX=9606 GN=ZNF185 PE=1 SV=3" "0.000" "False" "4.549" "3" "2" "2" "2" "689" "73.5" "7.01" "3.28" "2" "" "cytoskeleton;other cell component" "other molecular function" "" "7739" "ENSG00000147394; ENSG00000292196" "ZNF185" "A4FTV3; A6NME5; B4DLE9; B7Z771; B8K2L9; B8K2M0; B8K2M1; B8K2M2; E9PFR6; F5GXF7; F5GZL4; F8W8V7; H0Y4M8; hsa:7739; O00345; O15231; Q8N1R8; Q9NSD2" "" "" "0" "0" "1.143" "0.983" "1.140" "1.033" "0.991" "0.951" "0.958" "0.992" "0.994" "178.1" "203.7" "175.1" "203.1" "184.0" "176.6" "169.3" "170.6" "176.7" "177.1" "" "" "" "" "" "" "" "" "" "" "166.9" "168.5" "162.6" "157.0" "156.8" "168.7" "154.7" "151.5" "176.7" "170.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9059271771169400119" "False" "High" "IsMasterProtein" "Q9UBK9" "Protein UXT OS=Homo sapiens OX=9606 GN=UXT PE=1 SV=1" "0.000" "False" "4.549" "10" "2" "2" "2" "157" "18.2" "7.59" "7.38" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02996" "8409" "ENSG00000126756" "UXT" "A0A0C4DFR8; B2R561; hsa:8409; Q5JZG3; Q9UBK9; Q9Y6E5" "" "Transcriptional Regulation by E2F6" "1" "0" "0.938" "1.065" "0.920" "0.977" "1.051" "0.887" "0.997" "1.046" "1.000" "524.2" "491.6" "558.2" "482.1" "512.1" "550.8" "465.1" "522.7" "548.5" "524.3" "" "" "" "" "" "" "" "" "" "" "491.1" "406.8" "518.2" "372.6" "436.5" "526.2" "425.0" "464.1" "548.5" "504.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1997120607862774840" "False" "High" "IsMasterProtein" "O00189" "AP-4 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP4M1 PE=1 SV=2" "0.000" "False" "4.520" "6" "2" "2" "2" "453" "49.9" "7.20" "3.47" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00928, Pf01217" "9179" "ENSG00000221838" "AP4M1" "D6W5U1; hsa:9179; O00189; Q8WV65; Q9UHK9" "" "Lysosome Vesicle Biogenesis" "1" "0" "0.931" "0.970" "0.923" "1.139" "1.058" "0.929" "0.970" "1.000" "0.979" "133.9" "124.7" "129.8" "123.5" "152.5" "141.6" "124.4" "129.8" "133.8" "131.1" "" "" "" "" "" "" "" "" "" "" "125.4" "103.2" "120.5" "95.5" "130.0" "135.3" "113.7" "115.3" "133.8" "126.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8069107240958525203" "False" "High" "IsMasterProtein" "Q92993" "Histone acetyltransferase KAT5 OS=Homo sapiens OX=9606 GN=KAT5 PE=1 SV=2" "0.000" "False" "4.517" "3" "2" "2" "2" "513" "58.5" "8.48" "4.62" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01853, Pf11717, Pf17772" "10524" "ENSG00000172977" "KAT5" "B4E3C7; C9JL99; hsa:10524; O95624; Q13430; Q17RW5; Q561W3; Q6GSE8; Q92993; Q9BWK7" "Androgen receptor signaling pathway; ATM signaling in development and disease ; Joubert syndrome; Gastrin signaling pathway; HDAC6 interactions in the central nervous system" "Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Estrogen-dependent gene expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Cardiogenesis; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); Sensing of DNA Double Strand Breaks" "27" "0" "1.078" "0.926" "0.991" "0.944" "1.015" "1.121" "1.083" "1.082" "1.011" "158.6" "170.9" "146.9" "157.1" "149.8" "161.0" "177.8" "171.7" "171.6" "160.3" "" "" "" "" "" "" "" "" "" "" "148.6" "141.4" "136.4" "121.5" "127.7" "153.8" "162.4" "152.5" "171.6" "154.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4433191864106447347" "False" "High" "IsMasterProtein" "Q96N38" "Zinc finger protein 714 OS=Homo sapiens OX=9606 GN=ZNF714 PE=1 SV=3" "0.000" "False" "4.504" "4" "2" "4" "1" "554" "63.8" "9.10" "7.46" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "148206" "" "ZNF714" "hsa:148206; Q49AI1; Q86W65; Q8ND40; Q96N38" "" "Generic Transcription Pathway" "1" "0" "0.974" "1.172" "1.043" "1.049" "1.161" "0.968" "1.207" "1.105" "1.120" "110.3" "107.5" "129.4" "115.1" "115.7" "128.2" "106.8" "133.2" "122.0" "123.6" "" "" "" "" "" "" "" "" "" "" "103.4" "88.9" "120.1" "88.9" "98.6" "122.4" "97.6" "118.3" "122.0" "119.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7527678404860705700" "False" "High" "IsMasterProtein" "Q96K21" "Abscission/NoCut checkpoint regulator OS=Homo sapiens OX=9606 GN=ZFYVE19 PE=1 SV=3" "0.000" "False" "4.497" "5" "3" "3" "2" "471" "51.5" "5.73" "8.74" "3" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf01363" "84936" "ENSG00000166140" "ZFYVE19" "B3KVB2; C9JNF4; H3BUF9; hsa:84936; Q86WC2; Q8WU96; Q96K21" "" "" "0" "1" "0.982" "0.910" "1.071" "0.959" "0.963" "1.023" "0.979" "0.905" "0.949" "505.2" "496.1" "459.7" "540.9" "484.3" "486.7" "517.0" "494.4" "457.3" "479.5" "" "" "" "" "" "" "" "" "" "" "473.4" "410.5" "426.8" "418.2" "412.8" "465.0" "472.4" "439.0" "457.3" "461.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3054532643706144768" "False" "High" "IsMasterProtein" "Q9H0W9" "Ester hydrolase C11orf54 OS=Homo sapiens OX=9606 GN=C11orf54 PE=1 SV=1" "0.000" "False" "4.491" "5" "2" "4" "2" "315" "35.1" "6.70" "10.40" "2" "" "nucleus" "other molecular function" "Pf08925" "28970" "ENSG00000182919" "C11orf54" "A8K850; hsa:28970; Q6FI88; Q6XYB0; Q96EI3; Q96IX1; Q9H0W9; Q9Y6B4" "" "" "0" "0" "1.010" "1.039" "0.949" "1.000" "1.111" "0.926" "1.016" "0.958" "0.985" "800.1" "808.4" "831.6" "759.0" "800.5" "888.7" "740.7" "812.6" "766.7" "788.5" "" "" "" "" "" "" "" "" "" "" "749.7" "669.0" "772.0" "586.8" "682.3" "849.0" "676.8" "721.5" "766.7" "759.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-411341991637906360" "False" "High" "IsMasterProtein" "P27448" "MAP/microtubule affinity-regulating kinase 3 OS=Homo sapiens OX=9606 GN=MARK3 PE=1 SV=5" "0.000" "False" "4.452" "2" "2" "2" "2" "753" "84.4" "9.57" "6.34" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00627, Pf02149" "4140" "ENSG00000075413" "MARK3" "A0A0A0MQR8; A0A0A0MST9; A0A0A0MT23; hsa:4140; O60219; P27448; Q86TT8; Q8TB41; Q8WX83; Q96RG1; Q9UMY9; Q9UN34" "Complement system in neuronal development and plasticity" "Signaling by BRAF and RAF1 fusions; RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "10" "0" "1.072" "1.055" "1.126" "1.079" "1.058" "1.115" "1.032" "1.106" "1.079" "277.7" "297.7" "292.9" "312.6" "299.6" "293.8" "309.7" "286.6" "307.0" "299.6" "" "" "" "" "" "" "" "" "" "" "260.2" "246.3" "271.9" "241.6" "255.3" "280.7" "283.0" "254.5" "307.0" "288.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3643630707960143102" "False" "High" "IsMasterProtein" "Q4KWH8" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 OS=Homo sapiens OX=9606 GN=PLCH1 PE=1 SV=1" "0.000" "False" "4.452" "0" "1" "6" "1" "1693" "189.1" "7.74" "13.06" "1" "other metabolic processes;transport;signal transduction" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00168, Pf00387, Pf00388, Pf09279, Pf16457" "23007" "ENSG00000114805" "PLCH1" "hsa:23007; Q29RV9; Q4KWH8; Q4KWH9; Q68CN0; Q86XK4; Q9H9U2; Q9UPT3" "Mesodermal commitment pathway; GPR40 pathway" "Synthesis of IP3 and IP4 in the cytosol" "3" "0" "0.971" "1.091" "1.037" "1.074" "1.126" "1.016" "1.176" "1.128" "1.077" "176.1" "170.9" "192.1" "182.6" "189.2" "198.3" "178.9" "207.0" "198.6" "189.7" "" "" "" "" "" "" "" "" "" "" "165.0" "141.4" "178.3" "141.2" "161.3" "189.4" "163.4" "183.8" "198.6" "182.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5469574299663466694" "False" "High" "IsMasterProtein" "P11233" "Ras-related protein Ral-A OS=Homo sapiens OX=9606 GN=RALA PE=1 SV=1" "0.000" "False" "4.449" "7" "2" "2" "2" "206" "23.6" "7.11" "5.63" "2" "cell cycle OR cell proliferation;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00071" "5898" "ENSG00000006451" "RALA" "A4D1W3; hsa:5898; P11233" "RalA downstream regulated genes; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; p38MAPK events" "8" "0" "1.224" "0.886" "0.894" "0.770" "0.970" "0.846" "0.880" "1.230" "0.993" "232.6" "284.8" "206.1" "208.0" "179.1" "225.6" "196.8" "204.8" "286.0" "231.0" "" "" "" "" "" "" "" "" "" "" "217.9" "235.6" "191.3" "160.8" "152.6" "215.5" "179.8" "181.8" "286.0" "222.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7107318601171383488" "False" "High" "IsMasterProtein" "Q9Y3C8" "Ubiquitin-fold modifier-conjugating enzyme 1 OS=Homo sapiens OX=9606 GN=UFC1 PE=1 SV=3" "0.000" "False" "4.444" "10" "2" "3" "2" "167" "19.4" "7.40" "4.02" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes" "" "other molecular function" "Pf08694" "51506" "ENSG00000143222" "UFC1" "A8K9R1; D3DVF9; hsa:51506; Q549X0; Q5VTX1; Q9BS96; Q9P009; Q9Y3C8" "" "" "0" "0" "0.967" "1.058" "0.958" "1.174" "1.086" "0.958" "1.098" "1.054" "1.116" "241.0" "232.9" "255.1" "230.8" "282.9" "261.7" "230.9" "264.6" "254.1" "269.1" "" "" "" "" "" "" "" "" "" "" "225.8" "192.8" "236.8" "178.4" "241.2" "250.0" "211.0" "234.9" "254.1" "259.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3265591638708801395" "False" "High" "IsMasterProtein" "P62699" "Protein yippee-like 5 OS=Homo sapiens OX=9606 GN=YPEL5 PE=1 SV=1" "0.000" "False" "4.443" "18" "2" "2" "2" "121" "13.8" "7.31" "6.18" "2" "cell cycle OR cell proliferation" "non-structural extracellular;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03226" "51646" "ENSG00000119801" "YPEL5" "D6W568; hsa:51646; P62699; Q65Z97; Q8R174; Q9D6M1; Q9UMX7; Q9Y3C9" "Ciliary landscape" "Neutrophil degranulation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5152908157341258980" "False" "High" "IsMasterProtein" "P09017" "Homeobox protein Hox-C4 OS=Homo sapiens OX=9606 GN=HOXC4 PE=1 SV=2" "0.000" "False" "4.424" "5" "2" "2" "2" "264" "29.8" "9.13" "5.56" "2" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046" "3221" "ENSG00000198353" "HOXC4" "hsa:3221; P09017" "" "Activation of anterior HOX genes in hindbrain development during early embryogenesis" "1" "0" "1.009" "0.944" "1.072" "0.928" "0.977" "0.877" "1.546" "0.940" "0.900" "110.9" "111.9" "104.7" "118.9" "102.9" "108.4" "97.3" "171.5" "104.3" "99.9" "" "" "" "" "" "" "" "" "" "" "103.9" "92.6" "97.2" "91.9" "87.7" "103.6" "88.9" "152.3" "104.3" "96.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5217952952055268548" "False" "High" "IsMasterProtein" "P49207" "Large ribosomal subunit protein eL34 OS=Homo sapiens OX=9606 GN=RPL34 PE=1 SV=3" "0.000" "False" "4.423" "14" "2" "2" "2" "117" "13.3" "11.47" "4.34" "2" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01199" "6164" "ENSG00000109475" "RPL34" "hsa:6164; P49207; Q6FG66; Q9BUZ2" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.124" "1.097" "1.206" "1.179" "1.066" "1.114" "1.102" "1.074" "1.069" "138.0" "155.2" "151.4" "166.5" "162.7" "147.2" "153.8" "152.1" "148.3" "147.5" "" "" "" "" "" "" "" "" "" "" "129.3" "128.4" "140.6" "128.7" "138.7" "140.6" "140.5" "135.0" "148.3" "142.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8993746763041335004" "False" "High" "IsMasterProtein" "Q69YQ0" "Cytospin-A OS=Homo sapiens OX=9606 GN=SPECC1L PE=1 SV=3" "0.000" "False" "4.419" "2" "2" "2" "1" "1117" "124.5" "5.76" "6.31" "2" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf00307" "23384" "ENSG00000100014" "SPECC1L" "B7Z758; F5H1H6; hsa:23384; O15081; Q69YQ0" "" "" "0" "0" "1.453" "1.153" "1.285" "1.449" "1.148" "1.531" "1.314" "1.419" "1.297" "43.0" "62.5" "49.6" "55.2" "62.3" "49.3" "65.8" "56.5" "61.0" "55.7" "" "" "" "" "" "" "" "" "" "" "40.3" "51.7" "46.0" "42.7" "53.1" "47.1" "60.1" "50.2" "61.0" "53.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8100035487755028303" "False" "High" "IsMasterProtein" "P51957" "Serine/threonine-protein kinase Nek4 OS=Homo sapiens OX=9606 GN=NEK4 PE=1 SV=2" "0.000" "False" "4.414" "2" "2" "2" "2" "841" "94.5" "7.90" "3.01" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;other cell component" "kinase activity;other molecular function" "Pf00069" "6787" "ENSG00000114904" "NEK4" "A5YM70; B2R633; B7Z200; P51957; Q6P576" "" "" "0" "0" "1.063" "1.019" "0.852" "0.830" "0.906" "0.849" "0.779" "0.768" "1.083" "46.8" "49.8" "47.7" "39.9" "38.8" "42.4" "39.7" "36.5" "36.0" "50.7" "" "" "" "" "" "" "" "" "" "" "43.9" "41.2" "44.3" "30.8" "33.1" "40.6" "36.3" "32.4" "36.0" "48.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "172063933685251467" "False" "High" "IsMasterProtein" "Q9BTA9" "WW domain-containing adapter protein with coiled-coil OS=Homo sapiens OX=9606 GN=WAC PE=1 SV=3" "0.000" "False" "4.398" "3" "2" "2" "2" "647" "70.7" "9.45" "4.56" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf00397" "51322" "ENSG00000095787" "WAC" "A8K2A9; C9JBT9; D3DRW5; D3DRW6; D3DRW7; hsa:51322; Q53EN9; Q5JU75; Q5JU77; Q5VXK0; Q5VXK2; Q8TCK1; Q96DP3; Q96FW6; Q96JI3; Q9BTA9" "" "E3 ubiquitin ligases ubiquitinate target proteins" "1" "0" "0.795" "0.894" "0.871" "0.981" "0.857" "0.949" "0.969" "0.901" "0.772" "75.4" "60.0" "67.4" "65.7" "74.0" "64.6" "71.5" "73.0" "67.9" "58.2" "" "" "" "" "" "" "" "" "" "" "70.7" "49.6" "62.6" "50.8" "63.0" "61.7" "65.4" "64.8" "67.9" "56.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "151514905296234920" "False" "High" "IsMasterProtein" "Q99759" "Mitogen-activated protein kinase kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP3K3 PE=1 SV=2" "0.000" "False" "4.397" "3" "2" "2" "1" "626" "70.9" "8.84" "6.25" "2" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00564" "4215" "ENSG00000198909" "MAP3K3" "B2RCW2; D3DU15; hsa:4215; Q5BKZ6; Q8N3I9; Q99759" "IL-1 signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; EGF/EGFR signaling pathway; Insulin signaling; Pleural mesothelioma; GDNF signaling" "Interleukin-1 signaling" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2722320561760144151" "False" "High" "IsMasterProtein" "Q6GPH4" "XIAP-associated factor 1 OS=Homo sapiens OX=9606 GN=XAF1 PE=1 SV=1" "0.000" "False" "4.392" "5" "2" "2" "2" "301" "34.6" "8.19" "6.56" "2" "other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf18608, Pf21366" "54739" "ENSG00000132530" "XAF1" "A2T931; A2T932; A8K2L1; A8K9Y3; D3DTM6; hsa:54739; Q6GPH4; Q6MZE8; Q8N557; Q99982" "Copper homeostasis" "Interferon alpha/beta signaling" "2" "0" "1.025" "0.900" "0.990" "1.040" "0.953" "0.985" "1.003" "0.941" "0.980" "424.7" "435.5" "382.1" "420.6" "441.5" "404.7" "418.5" "426.0" "399.5" "416.1" "" "" "" "" "" "" "" "" "" "" "398.0" "360.3" "354.8" "325.2" "376.3" "386.7" "382.4" "378.2" "399.5" "400.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3335218336630157461" "False" "High" "IsMasterProtein" "Q9UFN0" "Protein NipSnap homolog 3A OS=Homo sapiens OX=9606 GN=NIPSNAP3A PE=1 SV=2" "0.000" "False" "4.384" "7" "2" "3" "2" "247" "28.4" "9.16" "4.85" "2" "" "cytosol;mitochondrion" "" "Pf07978" "25934" "ENSG00000136783" "NIPSNAP3A" "A6NM55; hsa:25934; Q5VX32; Q9BRV7; Q9H843; Q9P083; Q9UFN0" "" "" "0" "0" "0.993" "1.065" "1.149" "0.953" "1.029" "1.059" "0.879" "0.972" "0.968" "84.6" "84.0" "90.1" "97.2" "80.6" "87.0" "89.6" "74.4" "82.2" "81.9" "" "" "" "" "" "" "" "" "" "" "79.3" "69.5" "83.6" "75.1" "68.7" "83.2" "81.9" "66.1" "82.2" "78.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2926251137078555946" "False" "High" "IsMasterProtein" "Q96IZ5" "RNA-binding protein 41 OS=Homo sapiens OX=9606 GN=RBM41 PE=1 SV=2" "0.000" "False" "4.364" "4" "2" "3" "2" "413" "47.1" "8.70" "8.24" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00076" "55285" "ENSG00000089682" "RBM41" "hsa:55285; Q5JSN7; Q5JSN8; Q96IZ5; Q9H8F7; Q9NV04" "" "" "0" "0" "1.073" "0.941" "1.294" "1.026" "0.862" "1.094" "0.940" "0.831" "0.954" "127.3" "136.7" "119.8" "164.7" "130.6" "109.7" "139.3" "119.7" "105.8" "121.5" "" "" "" "" "" "" "" "" "" "" "119.3" "113.1" "111.2" "127.3" "111.3" "104.8" "127.3" "106.3" "105.8" "117.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7485362868972298733" "False" "High" "IsMasterProtein" "P14174" "Macrophage migration inhibitory factor OS=Homo sapiens OX=9606 GN=MIF PE=1 SV=4" "0.000" "False" "4.355" "14" "2" "4" "2" "115" "12.5" "7.88" "10.30" "2" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01187" "4282" "ENSG00000240972; ENSG00000276701" "MIF" "A5Z1R8; B2R4S3; hsa:4282; P14174; Q2V4Y5; Q6FHV0" "Adipogenesis; Spinal cord injury; HDAC6 interactions in the central nervous system" "Neutrophil degranulation; Cell surface interactions at the vascular wall; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "6" "0" "1.113" "0.914" "1.030" "0.904" "0.835" "1.001" "0.806" "0.800" "0.831" "390.2" "434.4" "356.7" "401.8" "352.6" "325.7" "390.6" "314.3" "312.3" "324.1" "" "" "" "" "" "" "" "" "" "" "365.6" "359.5" "331.2" "310.6" "300.6" "311.1" "356.9" "279.1" "312.3" "312.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2208639490373230766" "False" "High" "IsMasterProtein" "Q92882" "Osteoclast-stimulating factor 1 OS=Homo sapiens OX=9606 GN=OSTF1 PE=1 SV=2" "0.000" "False" "4.339" "7" "2" "4" "2" "214" "23.8" "5.68" "11.50" "2" "signal transduction;other biological processes" "other cell component" "other molecular function" "Pf00018, Pf12796" "26578" "ENSG00000134996" "OSTF1" "hsa:26578; Q5W126; Q92882; Q96IJ4" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5845419377566949929" "False" "High" "IsMasterProtein" "P61077" "Ubiquitin-conjugating enzyme E2 D3 OS=Homo sapiens OX=9606 GN=UBE2D3 PE=1 SV=1" "0.000" "False" "4.316" "12" "2" "3" "1" "147" "16.7" "7.80" "8.81" "2" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00179" "7323" "ENSG00000109332" "UBE2D3" "A6NJ93; A6NJB1; A6NM99; P47986; P61077; Q6IB88; Q6NXS4; Q8N924" "Proteasome degradation" "Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation; E3 ubiquitin ligases ubiquitinate target proteins; Peroxisomal protein import; IKK complex recruitment mediated by RIP1; Signaling by BMP; Inactivation of CSF3 (G-CSF) signaling; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "13" "0" "0.919" "0.991" "1.126" "0.967" "0.894" "0.908" "0.949" "1.236" "0.948" "104.8" "96.3" "103.8" "118.0" "101.3" "93.7" "95.1" "99.5" "129.5" "99.3" "" "" "" "" "" "" "" "" "" "" "98.2" "79.7" "96.4" "91.2" "86.3" "89.5" "86.9" "88.3" "129.5" "95.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "436282700212558245" "False" "High" "IsMasterProtein" "P17676" "CCAAT/enhancer-binding protein beta OS=Homo sapiens OX=9606 GN=CEBPB PE=1 SV=2" "0.000" "False" "4.307" "6" "3" "4" "3" "345" "36.1" "8.31" "6.62" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07716" "1051" "ENSG00000172216" "CEBPB" "A8K671; hsa:1051; P17676; Q96IH2; Q9H4Z5" "Folate-alcohol and cancer pathway hypotheses; IL-17 signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Differentiation of white and brown adipocyte; Transcriptional activation by NRF2 in response to phytochemicals; Ovarian infertility; Transcription factor regulation in adipogenesis; Lung fibrosis; IL-4 signaling pathway; Exercise-induced circadian regulation; White fat cell differentiation; Transcriptional cascade regulating adipogenesis; NRF2-ARE regulation; IL-18 signaling pathway; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; GDNF signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "Transcriptional regulation of white adipocyte differentiation; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Transcriptional regulation of granulopoiesis; Response of EIF2AK1 (HRI) to heme deficiency; ATF4 activates genes in response to endoplasmic reticulum stress; Response of EIF2AK4 (GCN2) to amino acid deficiency; Nuclear events stimulated by ALK signaling in cancer" "28" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4593935513655895610" "False" "High" "IsMasterProtein" "Q13614" "Myotubularin-related protein 2 OS=Homo sapiens OX=9606 GN=MTMR2 PE=1 SV=4" "0.000" "False" "4.305" "3" "2" "3" "2" "643" "73.3" "7.40" "6.19" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02893, Pf06602" "8898" "ENSG00000087053" "MTMR2" "A6NN98; hsa:8898; Q13614; Q9UPS9" "Intracellular trafficking proteins involved in CMT neuropathy" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Synthesis of PIPs at the ER membrane" "5" "0" "1.040" "0.951" "1.030" "0.982" "0.947" "0.935" "1.008" "0.912" "0.880" "195.6" "203.4" "186.0" "201.5" "192.2" "185.3" "182.9" "197.1" "178.4" "172.1" "" "" "" "" "" "" "" "" "" "" "183.3" "168.3" "172.7" "155.8" "163.8" "177.1" "167.1" "175.0" "178.4" "165.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7958389170144649522" "False" "High" "IsMasterProtein" "P45983" "Mitogen-activated protein kinase 8 OS=Homo sapiens OX=9606 GN=MAPK8 PE=1 SV=2" "0.000" "False" "4.294" "4" "2" "4" "1" "427" "48.3" "6.89" "10.94" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "5599" "ENSG00000107643" "MAPK8" "B5BTZ5; B7ZLV4; D3DX88; D3DX92; hsa:5599; P45983; Q15709; Q15712; Q15713; Q308M2" "Osteoclast signaling; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Nanoparticle triggered regulated necrosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; IL-3 signaling pathway; Nod-like receptor (NLR) signaling pathway; Transcriptional activation by NRF2 in response to phytochemicals; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; Fas ligand pathway and stress induction of heat shock proteins; RAC1/PAK1/p38/MMP2 pathway; Transcription factor regulation in adipogenesis; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Wnt signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; PDGFR-beta pathway; Wnt signaling in kidney disease; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; Wnt signaling; miRNA role in immune response in sepsis; Neovascularization processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; NRF2-ARE regulation; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Signal transduction through IL1R; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Regulatory circuits of the STAT3 signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; Pleural mesothelioma; CCL18 signaling pathway; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; Roles of ceramides in development of insulin resistance; IL-26 signaling pathways; 10q11.21q11.23 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; 5q35 copy number variation; 13q12.12 copy number variation; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "Signaling by ALK fusions and activated point mutants; FCERI mediated MAPK activation; NRAGE signals death through JNK; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Oxidative Stress Induced Senescence; WNT5:FZD7-mediated leishmania damping; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; DSCAM interactions; Activation of BIM and translocation to mitochondria ; Activation of the AP-1 family of transcription factors; NRIF signals cell death from the nucleus; Activation of BMF and translocation to mitochondria; Interleukin-38 signaling" "99" "0" "0.994" "1.103" "0.830" "1.017" "1.068" "0.994" "0.937" "0.928" "0.959" "141.0" "140.1" "155.5" "117.0" "143.4" "150.5" "140.2" "132.0" "130.8" "135.2" "" "" "" "" "" "" "" "" "" "" "132.1" "115.9" "144.4" "90.4" "122.2" "143.8" "128.1" "117.2" "130.8" "130.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2945830629131727042" "False" "High" "IsMasterProtein" "Q8NFG4" "Folliculin OS=Homo sapiens OX=9606 GN=FLCN PE=1 SV=1" "0.000" "False" "4.281" "3" "2" "2" "2" "579" "64.4" "6.23" "2.93" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf11704, Pf16692" "201163" "ENSG00000154803" "FLCN" "A6NJJ8; hsa:201163; Q6ZRX1; Q8NFG4; Q96BD2; Q96BE4" "Ciliopathies; Bardet-Biedl syndrome; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Amino acids regulate mTORC1" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7167041566668473319" "False" "High" "IsMasterProtein" "Q96RK0" "Protein capicua homolog OS=Homo sapiens OX=9606 GN=CIC PE=1 SV=3" "0.000" "False" "4.280" "1" "2" "2" "2" "2517" "257.9" "8.10" "4.48" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf16090" "23152" "ENSG00000079432" "CIC" "A0A7P0T9K5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-251433897532185408" "False" "High" "IsMasterProtein" "Q9H3H1" "tRNA dimethylallyltransferase OS=Homo sapiens OX=9606 GN=TRIT1 PE=1 SV=1" "0.000" "False" "4.279" "4" "2" "2" "2" "467" "52.7" "8.21" "5.09" "2" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf01715" "54802" "ENSG00000043514" "TRIT1" "A1A4X7; hsa:54802; Q3T7B5; Q5QPK5; Q5QPK6; Q6IAC9; Q96FJ3; Q96L45; Q9H3H1; Q9NXT7" "" "tRNA modification in the nucleus and cytosol; tRNA modification in the mitochondrion" "2" "0" "0.859" "0.820" "0.926" "0.941" "0.913" "0.881" "0.862" "0.800" "0.830" "187.7" "161.3" "153.8" "173.7" "176.7" "171.4" "165.4" "161.9" "150.1" "155.7" "" "" "" "" "" "" "" "" "" "" "175.8" "133.5" "142.8" "134.3" "150.6" "163.7" "151.1" "143.7" "150.1" "149.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6228980178887888836" "False" "High" "IsMasterProtein" "O94788" "Retinal dehydrogenase 2 OS=Homo sapiens OX=9606 GN=ALDH1A2 PE=1 SV=3" "0.000" "False" "4.274" "3" "2" "2" "1" "518" "56.7" "6.05" "5.92" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00171" "8854" "ENSG00000128918" "ALDH1A2" "B3KY52; B4DZR2; F5H2Y9; H0YM00; hsa:8854; O94788; Q2PJS6; Q8NHQ4; Q9UBR8; Q9UFY0" "Ethanol effects on histone modifications; 22q11.2 copy number variation syndrome; Nephrogenesis; Markers of kidney cell lineage; Vitamin A and carotenoid metabolism" "RA biosynthesis pathway" "6" "0" "0.940" "0.919" "1.006" "0.962" "0.966" "0.909" "0.909" "0.869" "0.980" "340.9" "320.4" "313.2" "342.9" "327.9" "329.2" "310.0" "310.0" "296.1" "334.0" "" "" "" "" "" "" "" "" "" "" "319.4" "265.1" "290.8" "265.1" "279.5" "314.5" "283.2" "275.3" "296.1" "321.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1428811385271777844" "False" "High" "IsMasterProtein" "Q9H488" "GDP-fucose protein O-fucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POFUT1 PE=1 SV=1" "0.000" "False" "4.251" "5" "2" "2" "2" "388" "43.9" "8.53" "4.75" "2" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf10250" "23509" "ENSG00000101346" "POFUT1" "A8K4R8; E1P5M4; hsa:23509; Q14685; Q5W185; Q9BW76; Q9H488" "" "Pre-NOTCH Processing in the Endoplasmic Reticulum" "1" "0" "1.060" "1.034" "1.131" "1.123" "1.065" "1.110" "0.976" "1.086" "1.082" "88.8" "94.1" "91.8" "100.4" "99.7" "94.6" "98.6" "86.7" "96.4" "96.0" "" "" "" "" "" "" "" "" "" "" "83.2" "77.9" "85.3" "77.6" "85.0" "90.4" "90.1" "77.0" "96.4" "92.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-618905356124197811" "False" "High" "IsMasterProtein" "Q9NQZ5" "StAR-related lipid transfer protein 7, mitochondrial OS=Homo sapiens OX=9606 GN=STARD7 PE=1 SV=2" "0.000" "False" "4.250" "4" "2" "2" "2" "370" "43.1" "8.95" "4.58" "2" "" "other membranes;mitochondrion" "other molecular function" "Pf01852" "56910" "ENSG00000084090" "STARD7" "D3DXG9; hsa:56910; Q53T44; Q6GU43; Q969M6; Q9NQZ5" "2q11.2 copy number variation syndrome" "Mitochondrial protein degradation; Synthesis of PC" "3" "0" "1.098" "0.894" "1.173" "0.987" "1.004" "1.076" "1.104" "1.027" "1.015" "139.7" "153.4" "124.9" "163.8" "137.8" "140.3" "150.3" "154.3" "143.4" "141.8" "" "" "" "" "" "" "" "" "" "" "130.9" "126.9" "115.9" "126.6" "117.5" "134.1" "137.3" "137.0" "143.4" "136.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2150748430854839914" "False" "High" "IsMasterProtein" "Q96JC1" "Vam6/Vps39-like protein OS=Homo sapiens OX=9606 GN=VPS39 PE=1 SV=2" "0.000" "False" "4.241" "2" "2" "2" "2" "886" "101.7" "6.99" "4.38" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf00780, Pf10366, Pf10367" "23339" "ENSG00000166887" "VPS39" "hsa:23339; O94869; Q71SQ6; Q7Z3V3; Q96B93; Q96JC1; Q96RM0" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "SARS-CoV-2 modulates autophagy" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4607454407969117171" "False" "High" "IsMasterProtein" "A6NED2" "RCC1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCCD1 PE=1 SV=1" "0.000" "False" "4.233" "5" "2" "2" "2" "376" "40.1" "5.27" "3.22" "2" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf00415" "91433" "ENSG00000166965" "RCCD1" "A6NED2; B2RTP9; hsa:91433; Q29RX6" "" "Protein hydroxylation" "1" "0" "1.043" "1.052" "1.152" "1.061" "0.998" "1.124" "1.060" "1.010" "1.115" "431.0" "449.5" "453.6" "496.4" "457.5" "430.3" "484.3" "456.9" "435.1" "480.4" "" "" "" "" "" "" "" "" "" "" "403.9" "372.0" "421.1" "383.8" "390.0" "411.1" "442.5" "405.7" "435.1" "462.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1125473546662306329" "False" "High" "IsMasterProtein" "Q13889" "General transcription factor IIH subunit 3 OS=Homo sapiens OX=9606 GN=GTF2H3 PE=1 SV=2" "0.000" "False" "4.232" "5" "2" "2" "2" "308" "34.4" "7.02" "5.37" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03850" "2967" "ENSG00000111358" "GTF2H3" "B2R819; B4DNZ6; hsa:2967; Q13889; Q7L0G0; Q96AT7" "Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "NoRC negatively regulates rRNA expression; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "33" "0" "0.962" "0.959" "0.943" "0.991" "0.964" "0.944" "0.989" "1.011" "1.069" "539.6" "519.1" "517.7" "509.0" "534.9" "520.3" "509.1" "533.8" "545.7" "577.0" "" "" "" "" "" "" "" "" "" "" "505.6" "429.5" "480.6" "393.5" "456.0" "497.1" "465.2" "474.0" "545.7" "555.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3185905528720532686" "False" "High" "IsMasterProtein" "P01903" "HLA class II histocompatibility antigen, DR alpha chain OS=Homo sapiens OX=9606 GN=HLA-DRA PE=1 SV=2" "0.000" "False" "4.231" "11" "2" "2" "2" "254" "28.6" "5.00" "5.37" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00993, Pf07654" "3122" "ENSG00000204287; ENSG00000206308; ENSG00000226260; ENSG00000227993; ENSG00000228987; ENSG00000230726; ENSG00000234794; ENSG00000277263" "HLA-DRA" "A2BET4; hsa:3122; P01903; Q30160; Q6IAZ1; Q861I2; Q9TP70" "Allograft rejection; PI3K/AKT/mTOR - vitamin D3 signaling; Ebola virus infection in host; Male infertility; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway; Cell interactions of the pancreatic cancer microenvironment; Cytokines and inflammatory response; 11p11.2 copy number variation syndrome" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "16" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2858962051142088186" "False" "High" "IsMasterProtein" "Q8WXE1" "ATR-interacting protein OS=Homo sapiens OX=9606 GN=ATRIP PE=1 SV=1" "0.000" "False" "4.211" "3" "2" "2" "2" "791" "85.8" "6.32" "4.83" "2" "DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "other molecular function" "" "84126" "ENSG00000164053" "ATRIP" "A8K6A3; A8K714; B2RCE7; B4DU92; B5MEB7; hsa:84126; Q69YK9; Q8NHQ2; Q8WUG7; Q8WXE1; Q96CL3; Q9HA30" "miRNA regulation of DNA damage response; ATR signaling; DNA damage response" "Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Fanconi Anemia Pathway; Activation of ATR in response to replication stress; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5315083588279200367" "False" "High" "IsMasterProtein" "Q96FZ2" "Abasic site processing protein HMCES OS=Homo sapiens OX=9606 GN=HMCES PE=1 SV=1" "0.000" "False" "4.207" "6" "2" "2" "2" "354" "40.5" "8.15" "5.63" "2" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf02586" "56941" "ENSG00000183624" "HMCES" "A6NJR9; hsa:56941; Q96FZ2; Q96G34; Q9NRP3" "" "" "0" "0" "1.218" "1.097" "1.155" "1.046" "1.022" "1.082" "1.039" "1.048" "0.992" "139.0" "169.3" "152.5" "160.6" "145.5" "142.1" "150.5" "144.5" "145.7" "137.9" "" "" "" "" "" "" "" "" "" "" "130.3" "140.1" "141.6" "124.2" "124.0" "135.7" "137.5" "128.3" "145.7" "132.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7340426752017437712" "False" "High" "IsMasterProtein" "Q9H8E8" "Cysteine-rich protein 2-binding protein OS=Homo sapiens OX=9606 GN=KAT14 PE=1 SV=3" "0.000" "False" "4.197" "2" "2" "2" "2" "782" "88.8" "6.57" "2.94" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00583" "57325" "ENSG00000149474" "KAT14" "A2A2I5; hsa:57325; Q96GW6; Q96IH3; Q9H8E8; Q9HBF0; Q9UIY5" "" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "2" "0" "0.767" "0.906" "0.900" "1.058" "1.119" "0.976" "0.987" "0.963" "1.035" "771.0" "591.0" "698.8" "694.0" "816.1" "863.1" "752.7" "760.6" "742.3" "798.1" "" "" "" "" "" "" "" "" "" "" "722.4" "489.0" "648.7" "536.5" "695.6" "824.6" "687.8" "675.4" "742.3" "768.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-888035968268434758" "False" "High" "IsMasterProtein" "Q9Y3B2" "Exosome complex component CSL4 OS=Homo sapiens OX=9606 GN=EXOSC1 PE=1 SV=1" "0.000" "False" "4.193" "9" "2" "2" "2" "195" "21.4" "8.24" "6.34" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity" "Pf10447, Pf14382" "51013" "ENSG00000171311" "EXOSC1" "B2R9B3; hsa:51013; Q5JTH3; Q9Y3B2" "" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "1.048" "1.013" "1.153" "1.106" "1.060" "1.004" "1.070" "1.085" "1.066" "225.2" "236.1" "228.2" "259.8" "249.1" "238.7" "226.1" "241.1" "244.4" "240.0" "" "" "" "" "" "" "" "" "" "" "211.1" "195.4" "211.8" "200.8" "212.3" "228.0" "206.6" "214.1" "244.4" "231.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3796638279955905475" "False" "High" "IsMasterProtein" "Q9NZ32" "Actin-related protein 10 OS=Homo sapiens OX=9606 GN=ACTR10 PE=1 SV=1" "0.000" "False" "4.188" "4" "2" "2" "2" "417" "46.3" "7.37" "2.99" "2" "transport" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "" "Pf00022" "55860" "ENSG00000131966" "ACTR10" "hsa:55860; Q9H9Y5; Q9NWY2; Q9NZ32" "" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation" "5" "0" "1.016" "1.091" "1.010" "1.024" "1.056" "0.955" "1.095" "1.150" "1.010" "185.9" "188.9" "202.7" "187.8" "190.3" "196.2" "177.6" "203.5" "213.8" "187.7" "" "" "" "" "" "" "" "" "" "" "174.2" "156.3" "188.2" "145.1" "162.2" "187.5" "162.2" "180.7" "213.8" "180.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5691153666596773717" "False" "High" "IsMasterProtein" "Q15746" "Myosin light chain kinase, smooth muscle OS=Homo sapiens OX=9606 GN=MYLK PE=1 SV=4" "0.000" "False" "4.188" "1" "2" "4" "1" "1914" "210.6" "6.15" "8.19" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00041, Pf00069, Pf07679, Pf16620" "4638" "ENSG00000065534" "MYLK" "B4DUE3; D3DN97; hsa:4638; O95796; O95797; O95798; O95799; Q14844; Q15746; Q16794; Q17S15; Q3ZCP9; Q5MY99; Q5MYA0; Q6P2N0; Q7Z4J0; Q9C0L5; Q9UBG5; Q9UBY6; Q9UIT9" "MicroRNAs in cardiomyocyte hypertrophy; Endothelin pathways; Focal adhesion; Physico-chemical features and toxicity-associated pathways; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Airway smooth muscle cell contraction; Regulation of actin cytoskeleton" "Smooth Muscle Contraction; RHO GTPases activate PAKs" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7755566090060093643" "False" "High" "IsMasterProtein" "P35914" "Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Homo sapiens OX=9606 GN=HMGCL PE=1 SV=2" "0.000" "False" "4.180" "5" "2" "2" "2" "325" "34.3" "8.54" "5.43" "2" "cell organization and biogenesis;other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00682" "3155" "ENSG00000117305" "HMGCL" "B4DUP4; B7UCC6; D3Y5K7; hsa:3155; P35914; Q6IBC0; Q96FP8" "Amino acid metabolism" "Peroxisomal protein import; Synthesis of Ketone Bodies" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7779362395337591117" "False" "High" "IsMasterProtein" "Q96FX7" "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Homo sapiens OX=9606 GN=TRMT61A PE=1 SV=1" "0.000" "False" "4.173" "11" "2" "2" "2" "289" "31.4" "7.36" "4.46" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf08704" "115708" "ENSG00000166166" "TRMT61A" "A6NN78; hsa:115708; Q8N7Q9; Q96FX7" "" "tRNA modification in the nucleus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2186364449985292911" "False" "High" "IsMasterProtein" "P63172" "Dynein light chain Tctex-type 1 OS=Homo sapiens OX=9606 GN=DYNLT1 PE=1 SV=1" "0.000" "False" "4.172" "14" "1" "1" "1" "113" "12.4" "5.08" "5.87" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf03645" "6993" "ENSG00000146425" "DYNLT1" "hsa:6993; P63172; Q15763; Q5VTU4" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome" "Neutrophil degranulation" "5" "0" "0.992" "0.971" "0.935" "0.968" "1.111" "0.891" "1.149" "1.119" "0.992" "279.7" "277.5" "271.6" "261.4" "270.9" "310.8" "249.3" "321.5" "313.0" "277.4" "" "" "" "" "" "" "" "" "" "" "262.1" "229.6" "252.1" "202.1" "230.9" "297.0" "227.8" "285.4" "313.0" "267.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1240749293216846131" "False" "High" "IsMasterProtein" "Q13526" "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 OS=Homo sapiens OX=9606 GN=PIN1 PE=1 SV=1" "0.000" "False" "4.156" "9" "2" "2" "2" "163" "18.2" "8.82" "5.20" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00397, Pf00639" "5300" "ENSG00000127445" "PIN1" "A8K4V9; hsa:5300; Q13526; Q53X75" "Novel intracellular components of RIG-I-like receptor pathway" "Regulation of TP53 Activity through Phosphorylation; ISG15 antiviral mechanism; Negative regulators of DDX58/IFIH1 signaling; PI5P Regulates TP53 Acetylation; RHO GTPases Activate NADPH Oxidases" "6" "0" "1.082" "0.954" "1.091" "1.070" "0.974" "1.006" "0.976" "0.926" "1.010" "465.0" "503.0" "443.7" "507.5" "497.6" "452.9" "467.8" "453.7" "430.8" "469.7" "" "" "" "" "" "" "" "" "" "" "435.7" "416.3" "411.9" "392.3" "424.1" "432.7" "427.4" "402.9" "430.8" "452.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4275613073034552076" "False" "High" "IsMasterProtein" "Q9NQI0" "Probable ATP-dependent RNA helicase DDX4 OS=Homo sapiens OX=9606 GN=DDX4 PE=1 SV=2" "0.000" "False" "4.151" "2" "2" "2" "1" "724" "79.3" "5.87" "5.64" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "54514" "ENSG00000152670" "DDX4" "A8K8Q2; B3KSF4; D6RDK4; E9PCD8; hsa:54514; Q5M7Z3; Q86VX0; Q9NQI0; Q9NT92; Q9NYB1" "Male infertility" "RND3 GTPase cycle; PIWI-interacting RNA (piRNA) biogenesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2814328454838082789" "False" "High" "IsMasterProtein" "Q6P087" "Mitochondrial mRNA pseudouridine synthase RPUSD3 OS=Homo sapiens OX=9606 GN=RPUSD3 PE=1 SV=3" "0.000" "False" "4.148" "5" "2" "2" "2" "351" "38.4" "10.32" "5.00" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00849" "285367" "ENSG00000156990" "RPUSD3" "B4DS39; hsa:285367; Q6P087; Q6P6A9; Q8N1B2; Q8NAV3" "" "" "0" "0" "1.044" "1.003" "1.125" "1.109" "1.063" "1.076" "1.033" "1.012" "1.016" "227.8" "237.9" "228.5" "256.2" "252.7" "242.1" "245.2" "235.4" "230.5" "231.4" "" "" "" "" "" "" "" "" "" "" "213.5" "196.8" "212.2" "198.1" "215.4" "231.3" "224.0" "209.0" "230.5" "222.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8873206142772037316" "False" "High" "IsMasterProtein" "Q9ULM6" "CCR4-NOT transcription complex subunit 6 OS=Homo sapiens OX=9606 GN=CNOT6 PE=1 SV=2" "0.000" "False" "4.144" "3" "2" "3" "2" "557" "63.3" "7.27" "5.78" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372, Pf13855" "" "ENSG00000113300" "CNOT6" "A7MD46; D3DWR0; Q9ULM6" "HDAC6 interactions in the central nervous system" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832676921386861974" "False" "High" "IsMasterProtein" "Q8WW33" "Gametocyte-specific factor 1 OS=Homo sapiens OX=9606 GN=GTSF1 PE=1 SV=2" "0.000" "False" "4.142" "13" "2" "4" "2" "167" "19.3" "6.51" "4.05" "2" "other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf05253" "121355" "ENSG00000170627" "GTSF1" "B3KQ60; hsa:121355; Q0VGM4; Q8N778; Q8WW33" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4003826422992493976" "False" "High" "IsMasterProtein" "Q9Y3D0" "Cytosolic iron-sulfur assembly component 2B OS=Homo sapiens OX=9606 GN=CIAO2B PE=1 SV=1" "0.000" "False" "4.140" "13" "1" "1" "1" "163" "17.7" "5.19" "8.20" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf01883" "51647" "ENSG00000166595" "CIAO2B" "hsa:51647; Q9Y3D0" "Iron-sulfur cluster biogenesis; 2q11.2 copy number variation syndrome" "Cytosolic iron-sulfur cluster assembly" "3" "0" "1.186" "0.906" "1.037" "0.923" "1.028" "0.896" "0.890" "0.940" "1.064" "176.3" "209.2" "159.7" "182.9" "162.7" "181.2" "158.0" "156.8" "165.8" "187.6" "" "" "" "" "" "" "" "" "" "" "165.2" "173.1" "148.2" "141.4" "138.7" "173.1" "144.3" "139.3" "165.8" "180.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8432390134706983747" "False" "High" "IsMasterProtein" "Q9ULT0" "Tetratricopeptide repeat protein 7A OS=Homo sapiens OX=9606 GN=TTC7A PE=1 SV=3" "0.000" "False" "4.136" "2" "2" "2" "2" "858" "96.1" "6.46" "5.75" "2" "other metabolic processes;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf13181, Pf19440" "57217" "ENSG00000068724" "TTC7A" "hsa:57217; Q2T9J9; Q6PIX4; Q8ND67; Q9BUS3; Q9ULT0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1035023352736906795" "False" "High" "IsMasterProtein" "O00399" "Dynactin subunit 6 OS=Homo sapiens OX=9606 GN=DCTN6 PE=1 SV=1" "0.000" "False" "4.118" "8" "2" "3" "2" "190" "20.7" "6.32" "7.54" "2" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;other cell component" "other molecular function" "" "10671" "ENSG00000104671" "DCTN6" "B2RAC1; hsa:10671; O00399" "Vasopressin-regulated water reabsorption" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic" "5" "0" "1.016" "0.983" "0.924" "0.962" "0.980" "1.034" "0.903" "0.905" "0.933" "604.5" "614.4" "594.1" "558.4" "581.8" "592.4" "625.4" "545.9" "547.3" "563.9" "" "" "" "" "" "" "" "" "" "" "566.5" "508.4" "551.6" "431.6" "495.9" "565.9" "571.4" "484.7" "547.3" "543.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7526904377414410620" "False" "High" "IsMasterProtein" "Q6NXR4" "TELO2-interacting protein 2 OS=Homo sapiens OX=9606 GN=TTI2 PE=1 SV=1" "0.000" "False" "4.112" "3" "2" "2" "2" "508" "56.9" "7.09" "5.80" "2" "other biological processes" "nucleus;other cell component" "" "Pf10521" "80185" "ENSG00000129696" "TTI2" "D3DSV7; hsa:80185; Q6NXR4; Q96IM2; Q9H5N4" "" "" "0" "0" "1.079" "1.047" "1.171" "1.119" "0.993" "0.981" "0.983" "1.008" "1.046" "291.4" "314.5" "305.1" "341.4" "326.1" "289.5" "285.9" "286.4" "293.8" "304.9" "" "" "" "" "" "" "" "" "" "" "273.1" "260.3" "283.2" "263.9" "278.0" "276.6" "261.2" "254.3" "293.8" "293.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2882906632265539377" "False" "High" "IsMasterProtein" "Q9NQV6" "PR domain zinc finger protein 10 OS=Homo sapiens OX=9606 GN=PRDM10 PE=1 SV=3" "0.000" "False" "4.105" "1" "2" "2" "2" "1147" "130.1" "6.74" "5.69" "2" "other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf12874, Pf21549" "56980" "ENSG00000170325" "PRDM10" "B7ZL71; G3XAE5; hsa:56980; J3KP23; Q17R90; Q2KHR4; Q863Z2; Q9NQV6; Q9NXI4; Q9ULI9" "" "" "0" "0" "0.966" "0.959" "0.874" "0.966" "0.997" "0.914" "0.901" "0.938" "1.016" "168.3" "162.7" "161.4" "147.1" "162.6" "167.7" "153.7" "151.6" "157.8" "170.9" "" "" "" "" "" "" "" "" "" "" "157.7" "134.6" "149.8" "113.7" "138.6" "160.2" "140.5" "134.6" "157.8" "164.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7251340200107887376" "False" "High" "IsMasterProtein" "Q6P9B9" "Integrator complex subunit 5 OS=Homo sapiens OX=9606 GN=INTS5 PE=1 SV=1" "0.000" "False" "4.101" "1" "2" "2" "2" "1019" "107.9" "7.05" "4.87" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "" "Pf14837, Pf14838" "80789" "ENSG00000185085" "INTS5" "hsa:80789; Q6P9B9; Q8N6W5; Q9C0G5" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "1.084" "1.053" "1.066" "1.066" "1.126" "1.142" "0.960" "1.021" "1.051" "136.8" "148.2" "144.0" "145.8" "145.8" "154.0" "156.1" "131.3" "139.7" "143.8" "" "" "" "" "" "" "" "" "" "" "128.1" "122.6" "133.7" "112.7" "124.3" "147.1" "142.7" "116.6" "139.7" "138.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4139945587606400296" "False" "High" "IsMasterProtein" "Q07352" "mRNA decay activator protein ZFP36L1 OS=Homo sapiens OX=9606 GN=ZFP36L1 PE=1 SV=1" "0.000" "False" "4.079" "5" "2" "3" "2" "338" "36.3" "7.96" "9.34" "2" "cell adhesion;cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf04553" "677" "ENSG00000185650" "ZFP36L1" "hsa:677; Q07352; Q13851" "Modulators of TCR signaling and T cell activation" "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2588914150961402946" "False" "High" "IsMasterProtein" "Q9H492" "Microtubule-associated proteins 1A/1B light chain 3A OS=Homo sapiens OX=9606 GN=MAP1LC3A PE=1 SV=2" "0.000" "False" "4.079" "12" "2" "2" "2" "121" "14.3" "8.68" "5.47" "2" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf02991" "84557" "ENSG00000101460" "MAP1LC3A" "E1P5P4; E1P5P5; hsa:84557; Q9BXW5; Q9H492" "Nanoparticle triggered autophagic cell death; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; CAMKK2 pathway; Clock-controlled autophagy in bone metabolism; 2q37 copy number variation syndrome; ADHD and autism (ASD) linked metabolic pathways and SNP; HDAC6 interactions in the central nervous system" "Macroautophagy; PINK1-PRKN Mediated Mitophagy; Receptor Mediated Mitophagy" "12" "0" "1.132" "1.015" "1.107" "1.100" "1.077" "1.042" "1.037" "1.003" "1.026" "152.0" "172.0" "154.3" "168.2" "167.2" "163.7" "158.4" "157.5" "152.4" "155.9" "" "" "" "" "" "" "" "" "" "" "142.4" "142.3" "143.3" "130.0" "142.5" "156.4" "144.7" "139.9" "152.4" "150.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3878380865412542485" "False" "High" "IsMasterProtein" "Q96G01" "Protein bicaudal D homolog 1 OS=Homo sapiens OX=9606 GN=BICD1 PE=1 SV=3" "0.000" "False" "4.075" "2" "2" "2" "2" "975" "110.7" "5.81" "4.65" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf09730" "636" "ENSG00000151746" "BICD1" "A8K2C3; F8W113; hsa:636; O43892; O43893; Q96G01" "" "COPI-independent Golgi-to-ER retrograde traffic" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4560958255263081327" "False" "High" "IsMasterProtein" "Q9Y6M9" "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 OS=Homo sapiens OX=9606 GN=NDUFB9 PE=1 SV=3" "0.000" "False" "4.063" "10" "2" "2" "2" "179" "21.8" "8.38" "5.23" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf05347" "4715" "ENSG00000147684" "NDUFB9" "B2R8M6; hsa:4715; Q9UQE8; Q9Y6M9" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial immune response to SARS-CoV-2; Oxidative phosphorylation" "Complex I biogenesis" "6" "0" "0.960" "1.048" "0.807" "0.975" "0.988" "0.938" "0.887" "0.817" "0.934" "240.4" "230.8" "251.9" "194.0" "234.5" "237.6" "225.5" "213.2" "196.4" "224.5" "" "" "" "" "" "" "" "" "" "" "225.3" "191.0" "233.9" "149.9" "199.9" "227.0" "206.1" "189.3" "196.4" "216.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5199956621996248182" "False" "High" "IsMasterProtein" "P18859" "ATP synthase-coupling factor 6, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PF PE=1 SV=1" "0.000" "False" "4.062" "18" "1" "1" "1" "108" "12.6" "9.52" "4.01" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05511" "522" "ENSG00000154723" "ATP5PF" "hsa:522; J3KQ83; P18859" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3124234521907955571" "False" "High" "IsMasterProtein" "Q9NX24" "H/ACA ribonucleoprotein complex subunit 2 OS=Homo sapiens OX=9606 GN=NHP2 PE=1 SV=1" "0.000" "False" "4.054" "12" "1" "1" "1" "153" "17.2" "8.22" "5.19" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01248" "55651" "ENSG00000145912" "NHP2" "A6NKY8; hsa:55651; Q9NX24; Q9P095" "" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "2" "0" "1.438" "1.359" "1.501" "1.548" "1.487" "1.598" "1.242" "1.456" "1.071" "33.6" "48.3" "45.6" "50.4" "52.0" "49.9" "53.6" "41.7" "48.9" "36.0" "" "" "" "" "" "" "" "" "" "" "31.5" "40.0" "42.4" "39.0" "44.3" "47.7" "49.0" "37.0" "48.9" "34.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4493911830020970266" "False" "High" "IsMasterProtein" "Q9BQE9" "B-cell CLL/lymphoma 7 protein family member B OS=Homo sapiens OX=9606 GN=BCL7B PE=1 SV=1" "0.000" "False" "4.054" "11" "1" "1" "1" "202" "22.2" "4.75" "4.43" "1" "cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "cytoskeletal activity" "Pf04714" "9275" "ENSG00000106635" "BCL7B" "A8K226; C9JWD3; D3DXF0; hsa:9275; O43769; Q13845; Q6ZW75; Q9BQE9" "7q11.23 copy number variation syndrome" "" "1" "0" "1.150" "1.072" "1.408" "1.179" "0.997" "1.011" "0.903" "0.993" "1.153" "31.2" "35.9" "33.4" "43.9" "36.8" "31.1" "31.5" "28.2" "31.0" "35.9" "" "" "" "" "" "" "" "" "" "" "29.2" "29.7" "31.0" "33.9" "31.3" "29.7" "28.8" "25.0" "31.0" "34.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2288858883428598643" "False" "High" "IsMasterProtein" "P11474" "Steroid hormone receptor ERR1 OS=Homo sapiens OX=9606 GN=ESRRA PE=1 SV=3" "0.000" "False" "4.028" "4" "2" "2" "2" "423" "45.5" "6.38" "2.75" "2" "signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105" "2101" "ENSG00000173153" "ESRRA" "hsa:2101; P11474; Q14514" "Energy metabolism; Nuclear receptors; Pre-implantation embryo; Mitochondrial gene expression" "PPARA activates gene expression; Regulation of RUNX2 expression and activity; Transcriptional activation of mitochondrial biogenesis; Nuclear Receptor transcription pathway" "8" "0" "1.109" "0.900" "1.106" "1.018" "1.137" "1.125" "0.928" "1.000" "1.055" "110.5" "122.5" "99.4" "122.2" "112.5" "125.6" "124.3" "102.6" "110.5" "116.5" "" "" "" "" "" "" "" "" "" "" "103.5" "101.4" "92.3" "94.4" "95.9" "120.0" "113.6" "91.1" "110.5" "112.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2438829351584223840" "False" "High" "IsMasterProtein" "O75529" "TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L OS=Homo sapiens OX=9606 GN=TAF5L PE=1 SV=1" "0.000" "False" "4.017" "3" "2" "2" "2" "589" "66.1" "5.88" "5.71" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf04494" "27097" "ENSG00000135801" "TAF5L" "hsa:27097; O75529; Q5TDI5; Q5TDI6; Q8IW31" "" "HATs acetylate histones" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4477039985153313933" "False" "High" "IsMasterProtein" "O94952" "F-box only protein 21 OS=Homo sapiens OX=9606 GN=FBXO21 PE=1 SV=2" "0.000" "False" "4.011" "3" "2" "2" "2" "628" "72.2" "6.09" "2.77" "2" "protein metabolism;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf08755, Pf13369" "23014" "ENSG00000135108" "FBXO21" "B3KMF0; hsa:23014; O94952; Q5BJG0; Q9H087" "" "Neddylation; Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6535746548150786198" "False" "High" "IsMasterProtein" "Q6MZP7" "Protein lin-54 homolog OS=Homo sapiens OX=9606 GN=LIN54 PE=1 SV=3" "0.000" "False" "4.011" "3" "2" "2" "2" "749" "79.4" "9.01" "4.87" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03638" "132660" "ENSG00000189308" "LIN54" "hsa:132660; Q32M68; Q32M69; Q6MZP7; Q6N071; Q76B60" "DYRK1A involvement regarding cell proliferation in brain development" "G1/S-Specific Transcription; Polo-like kinase mediated events; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "8" "0" "1.096" "1.050" "1.203" "1.130" "1.212" "1.104" "1.059" "1.092" "1.084" "176.5" "193.5" "185.3" "212.3" "199.5" "213.9" "194.8" "186.8" "192.6" "191.3" "" "" "" "" "" "" "" "" "" "" "165.3" "160.1" "172.0" "164.1" "170.0" "204.4" "178.0" "165.8" "192.6" "184.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2007985770655079458" "False" "High" "IsMasterProtein" "Q9BPX6" "Calcium uptake protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=MICU1 PE=1 SV=1" "0.000" "False" "4.004" "4" "1" "1" "1" "476" "54.3" "8.41" "4.01" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf13202" "10367" "ENSG00000107745" "MICU1" "A8MV96; B3KN20; B4DJH9; B4DPI1; B5MBY3; D3YTJ3; hsa:10367; O75785; Q9BPX6; Q9H9N6; Q9UFX0" "" "Processing of SMDT1" "2" "0" "1.313" "1.022" "1.238" "1.284" "1.171" "1.075" "1.087" "1.115" "1.255" "38.8" "50.9" "39.6" "48.0" "49.8" "45.4" "41.7" "42.2" "43.2" "48.7" "" "" "" "" "" "" "" "" "" "" "36.3" "42.1" "36.8" "37.1" "42.5" "43.4" "38.1" "37.4" "43.2" "46.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4489677363022304149" "False" "High" "IsMasterProtein" "Q8IYU8" "Calcium uptake protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=MICU2 PE=1 SV=2" "0.000" "False" "4.002" "5" "1" "1" "1" "434" "49.6" "9.09" "4.64" "1" "transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "" "221154" "ENSG00000165487" "MICU2" "hsa:221154; Q8IYU8; Q8N0T6; Q8NAX8" "" "Mitochondrial protein degradation; Processing of SMDT1" "3" "0" "1.416" "1.085" "1.204" "1.324" "1.140" "1.352" "1.019" "1.153" "1.098" "25.7" "36.4" "27.9" "31.0" "34.1" "29.3" "34.8" "26.2" "29.7" "28.3" "" "" "" "" "" "" "" "" "" "" "24.1" "30.2" "25.9" "24.0" "29.1" "28.0" "31.8" "23.3" "29.7" "27.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4744508132045603899" "False" "High" "IsMasterProtein" "Q9BZG8" "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 OS=Homo sapiens OX=9606 GN=DPH1 PE=1 SV=3" "0.000" "False" "4.001" "4" "2" "2" "2" "438" "48.1" "7.84" "3.58" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01866" "1801" "ENSG00000108963" "DPH1" "A0A6Q8JGF9; D3DTI3; hsa:1801; Q16439; Q4VBA2; Q9BTW7; Q9BZG8; Q9UCY0" "" "Synthesis of diphthamide-EEF2" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2203431477329866008" "False" "High" "IsMasterProtein" "Q9BZK3" "Putative nascent polypeptide-associated complex subunit alpha-like protein OS=Homo sapiens OX=9606 GN=NACA4P PE=5 SV=1" "0.000" "False" "4.000" "7" "1" "2" "1" "213" "23.3" "4.59" "8.59" "1" "other biological processes" "translational apparatus;other cell component" "other molecular function" "Pf01849" "" "" "NACA4P" "Q9BZK3" "" "" "0" "0" "1.192" "1.011" "1.025" "1.052" "1.070" "1.019" "0.997" "0.917" "1.027" "209.3" "249.6" "211.5" "214.6" "220.2" "223.9" "213.2" "208.7" "192.0" "215.0" "" "" "" "" "" "" "" "" "" "" "196.1" "206.5" "196.4" "165.9" "187.7" "213.9" "194.8" "185.3" "192.0" "207.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2154176655508352970" "False" "High" "IsMasterProtein" "Q13642" "Four and a half LIM domains protein 1 OS=Homo sapiens OX=9606 GN=FHL1 PE=1 SV=4" "0.000" "False" "3.999" "4" "1" "1" "1" "323" "36.2" "8.97" "5.10" "1" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00412" "2273" "ENSG00000022267" "FHL1" "B7Z5T4; B7Z793; hsa:2273; O95212; Q13230; Q13642; Q13645; Q5JXI7; Q5M7Y6; Q6IB30; Q9NZ40; Q9UKZ8; Q9Y630" "Notch signaling pathway" "" "1" "0" "0.948" "0.937" "0.916" "1.015" "1.017" "0.859" "0.994" "0.924" "1.074" "189.5" "179.7" "177.6" "173.6" "192.3" "192.7" "162.8" "188.5" "175.0" "203.6" "" "" "" "" "" "" "" "" "" "" "177.6" "148.7" "164.8" "134.2" "163.9" "184.1" "148.7" "167.3" "175.0" "196.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6536357785872288465" "False" "High" "IsMasterProtein" "P48723" "Heat shock 70 kDa protein 13 OS=Homo sapiens OX=9606 GN=HSPA13 PE=1 SV=1" "0.000" "False" "3.994" "3" "2" "2" "2" "471" "51.9" "5.76" "4.68" "2" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00012" "6782" "ENSG00000155304" "HSPA13" "B2R616; hsa:6782; P48723; Q8NE40" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "0.998" "1.041" "1.002" "1.023" "1.005" "1.034" "0.966" "0.898" "0.969" "227.0" "226.5" "236.3" "227.4" "232.2" "228.2" "234.8" "219.4" "204.0" "219.9" "" "" "" "" "" "" "" "" "" "" "212.7" "187.4" "219.3" "175.8" "197.9" "218.0" "214.6" "194.8" "204.0" "211.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6522412944191385699" "False" "High" "IsMasterProtein" "Q9HCM7" "Fibrosin-1-like protein OS=Homo sapiens OX=9606 GN=FBRSL1 PE=1 SV=4" "0.000" "False" "3.991" "1" "1" "1" "1" "1045" "110.8" "9.67" "4.74" "1" "" "" "" "Pf15336" "57666" "ENSG00000112787" "FBRSL1" "hsa:57666; Q86XQ1; Q9HCM7" "" "" "0" "0" "0.984" "0.905" "0.956" "1.039" "0.946" "0.930" "0.805" "0.735" "0.929" "233.8" "230.0" "211.7" "223.5" "243.0" "221.2" "217.5" "188.3" "171.8" "217.2" "" "" "" "" "" "" "" "" "" "" "219.1" "190.3" "196.5" "172.8" "207.2" "211.3" "198.7" "167.2" "171.8" "209.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4573185288358324905" "False" "High" "IsMasterProtein" "P21953" "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHB PE=1 SV=2" "0.000" "False" "3.989" "3" "1" "1" "1" "392" "43.1" "6.29" "3.87" "1" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf02779, Pf02780" "594" "ENSG00000083123" "BCKDHB" "hsa:594; P21953; Q5T2J3; Q9BQL0" "Primary ovarian insufficiency" "Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism" "3" "0" "1.171" "1.066" "1.355" "1.107" "1.021" "1.193" "1.092" "1.072" "1.074" "224.8" "263.1" "239.5" "304.6" "248.8" "229.6" "268.2" "245.5" "240.9" "241.4" "" "" "" "" "" "" "" "" "" "" "210.6" "217.7" "222.4" "235.4" "212.1" "219.3" "245.0" "218.0" "240.9" "232.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8069995448672304033" "False" "High" "IsMasterProtein" "P01703" "Immunoglobulin lambda variable 1-40 OS=Homo sapiens OX=9606 GN=IGLV1-40 PE=1 SV=2" "0.000" "False" "3.988" "14" "1" "1" "1" "118" "12.3" "5.74" "4.77" "1" "other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf07686" "" "ENSG00000211653; ENSG00000274575" "IGLV1-40" "A0A075B6J0; P01703" "" "Initial triggering of complement; Classical antibody-mediated complement activation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Scavenging of heme from plasma; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "19" "0" "1.141" "1.010" "0.986" "0.986" "0.868" "0.895" "0.857" "0.812" "0.954" "170.8" "194.8" "172.4" "168.4" "168.5" "148.3" "152.8" "146.3" "138.7" "162.9" "" "" "" "" "" "" "" "" "" "" "160.0" "161.2" "160.1" "130.2" "143.6" "141.7" "139.6" "129.9" "138.7" "156.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4946696058487786946" "False" "High" "IsMasterProtein" "Q9UHJ6" "Sedoheptulokinase OS=Homo sapiens OX=9606 GN=SHPK PE=1 SV=4" "0.000" "False" "3.988" "4" "1" "1" "1" "478" "51.5" "6.83" "3.91" "1" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00370" "23729" "ENSG00000197417" "SHPK" "B2R640; Q8WUH3; Q9UHJ6" "" "Pentose phosphate pathway" "1" "0" "1.123" "1.116" "1.337" "1.232" "1.110" "1.056" "1.191" "1.109" "0.978" "51.7" "58.1" "57.7" "69.1" "63.7" "57.4" "54.6" "61.6" "57.3" "50.6" "" "" "" "" "" "" "" "" "" "" "48.5" "48.0" "53.6" "53.5" "54.3" "54.8" "49.9" "54.7" "57.3" "48.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8899762439150821704" "False" "High" "IsMasterProtein" "Q9H9Q4" "Non-homologous end-joining factor 1 OS=Homo sapiens OX=9606 GN=NHEJ1 PE=1 SV=1" "0.001" "False" "3.980" "5" "1" "1" "1" "299" "33.3" "5.97" "4.75" "1" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09302" "79840" "ENSG00000187736" "NHEJ1" "B8ZZA4; hsa:79840; Q4ZFW7; Q6IA64; Q96JS9; Q9H9Q4" "Non-homologous end joining; DNA repair pathways, full network" "Nonhomologous End-Joining (NHEJ)" "3" "0" "1.005" "0.986" "1.056" "1.145" "1.090" "0.994" "1.047" "0.982" "0.882" "67.1" "67.4" "66.2" "70.8" "76.8" "73.1" "66.7" "70.2" "65.9" "59.2" "" "" "" "" "" "" "" "" "" "" "62.9" "55.8" "61.4" "54.7" "65.5" "69.9" "61.0" "62.4" "65.9" "57.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3097608289690062130" "False" "High" "IsMasterProtein" "P43250" "G protein-coupled receptor kinase 6 OS=Homo sapiens OX=9606 GN=GRK6 PE=1 SV=2" "0.001" "False" "3.979" "3" "2" "2" "2" "576" "65.9" "8.00" "4.61" "2" "cell-cell signaling;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00615" "2870" "ENSG00000198055" "GRK6" "hsa:2870; O60541; P43250; Q13652" "Follicle stimulating hormone (FSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; Chemokine signaling pathway; Calcium regulation in cardiac cells; 5q35 copy number variation" "G alpha (s) signalling events" "7" "0" "1.005" "1.018" "1.177" "1.025" "1.098" "1.177" "1.052" "1.058" "1.085" "105.0" "105.5" "106.8" "123.6" "107.6" "115.2" "123.5" "110.5" "111.1" "113.9" "" "" "" "" "" "" "" "" "" "" "98.3" "87.3" "99.2" "95.5" "91.7" "110.1" "112.9" "98.1" "111.1" "109.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2518500882063606702" "False" "High" "IsMasterProtein" "Q13164" "Mitogen-activated protein kinase 7 OS=Homo sapiens OX=9606 GN=MAPK7 PE=1 SV=2" "0.001" "False" "3.977" "3" "1" "1" "1" "816" "88.3" "5.88" "4.86" "1" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5598" "ENSG00000166484" "MAPK7" "hsa:5598; Q13164; Q16634; Q59F50; Q6QLU7; Q7L4P4; Q969G1; Q96G51" "MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Brain-derived neurotrophic factor (BDNF) signaling pathway; S1P receptor signal transduction; Cardiac hypertrophic response; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; Pleural mesothelioma; GDNF signaling" "Senescence-Associated Secretory Phenotype (SASP); RET signaling; Gastrin-CREB signalling pathway via PKC and MAPK; ERKs are inactivated; Signalling to ERK5" "20" "0" "0.908" "0.900" "1.130" "0.980" "1.019" "1.171" "1.010" "0.912" "1.006" "35.4" "32.2" "31.9" "40.0" "34.7" "36.1" "41.5" "35.8" "32.3" "35.6" "" "" "" "" "" "" "" "" "" "" "33.2" "26.6" "29.6" "30.9" "29.6" "34.5" "37.9" "31.8" "32.3" "34.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7993967056221403717" "False" "High" "IsMasterProtein" "Q9BU02" "Thiamine-triphosphatase OS=Homo sapiens OX=9606 GN=THTPA PE=1 SV=3" "0.001" "False" "3.977" "5" "1" "1" "1" "230" "25.6" "4.82" "4.54" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf01928" "79178" "ENSG00000259431" "THTPA" "D3DS50; G3V4J3; hsa:79178; Q9BU02" "" "Vitamin B1 (thiamin) metabolism" "1" "0" "1.104" "1.091" "1.138" "1.044" "1.067" "1.079" "1.067" "1.069" "1.116" "228.6" "252.5" "249.4" "260.2" "238.6" "243.9" "246.8" "243.9" "244.3" "255.0" "" "" "" "" "" "" "" "" "" "" "214.2" "208.9" "231.5" "201.1" "203.4" "233.0" "225.5" "216.6" "244.3" "245.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3817114050720704856" "False" "High" "IsMasterProtein" "Q9H867" "Protein N-lysine methyltransferase METTL21D OS=Homo sapiens OX=9606 GN=VCPKMT PE=1 SV=2" "0.001" "False" "3.969" "7" "2" "2" "2" "229" "25.8" "4.92" "0.00" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf10294" "79609" "ENSG00000100483" "VCPKMT" "B7ZLA3; B7ZLA4; hsa:79609; Q2M2X3; Q86T12; Q9H867" "" "Protein methylation" "1" "0" "0.831" "0.982" "0.917" "0.937" "0.874" "0.808" "1.099" "0.904" "0.876" "124.6" "103.5" "122.3" "114.2" "116.7" "108.9" "100.7" "136.9" "112.6" "109.1" "" "" "" "" "" "" "" "" "" "" "116.8" "85.6" "113.5" "88.3" "99.5" "104.1" "92.0" "121.6" "112.6" "105.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-531095149826683174" "False" "High" "IsMasterProtein" "Q86WX3" "Active regulator of SIRT1 OS=Homo sapiens OX=9606 GN=RPS19BP1 PE=1 SV=1" "0.001" "False" "3.959" "9" "1" "1" "1" "136" "15.4" "10.74" "4.68" "1" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf15684" "91582" "ENSG00000187051" "RPS19BP1" "B0QY96; hsa:91582; Q5JZA1; Q86WX3" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3522483334195236405" "False" "High" "IsMasterProtein" "Q13542" "Eukaryotic translation initiation factor 4E-binding protein 2 OS=Homo sapiens OX=9606 GN=EIF4EBP2 PE=1 SV=1" "0.001" "False" "3.958" "12" "1" "2" "1" "120" "12.9" "6.67" "6.97" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05456" "1979" "ENSG00000148730" "EIF4EBP2" "hsa:1979; Q13542" "Translation factors; Fragile X syndrome" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5656121017139874826" "False" "High" "IsMasterProtein" "Q01081" "Splicing factor U2AF 35 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF1 PE=1 SV=3" "0.001" "False" "3.958" "5" "1" "1" "1" "240" "27.9" "8.81" "4.51" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00642" "102724594; 7307" "ENSG00000160201" "U2AF1" "hsa:102724594; hsa:7307; Q01081; Q701P4; Q71RF1" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript" "5" "0" "1.221" "1.498" "0.925" "1.015" "0.949" "1.113" "1.016" "1.283" "1.265" "51.1" "62.5" "76.6" "47.3" "51.9" "48.6" "56.9" "52.0" "65.6" "64.7" "" "" "" "" "" "" "" "" "" "" "47.9" "51.7" "71.1" "36.6" "44.3" "46.4" "52.0" "46.1" "65.6" "62.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8862135404577219062" "False" "High" "IsMasterProtein" "Q9UJZ1" "Stomatin-like protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=STOML2 PE=1 SV=1" "0.001" "False" "3.957" "5" "1" "1" "1" "356" "38.5" "7.39" "4.66" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion" "signal transduction activity or receptor binding;other molecular function" "Pf01145, Pf16200" "30968" "ENSG00000165283" "STOML2" "B4E1K7; D3DRN3; hsa:30968; O60376; Q53G29; Q96FY2; Q9P042; Q9UJZ1" "" "Processing of SMDT1; Cellular response to mitochondrial stress" "2" "0" "1.067" "1.026" "1.170" "1.172" "1.082" "1.192" "0.996" "0.952" "1.048" "126.1" "134.5" "129.4" "147.6" "147.8" "136.4" "150.3" "125.6" "120.1" "132.2" "" "" "" "" "" "" "" "" "" "" "118.2" "111.3" "120.1" "114.1" "126.0" "130.4" "137.3" "111.5" "120.1" "127.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1233301175711817625" "False" "High" "IsMasterProtein" "P21926" "CD9 antigen OS=Homo sapiens OX=9606 GN=CD9 PE=1 SV=4" "0.001" "False" "3.950" "7" "2" "2" "2" "228" "25.4" "7.15" "5.84" "2" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding" "Pf00335" "928" "ENSG00000010278" "CD9" "D3DUQ9; hsa:928; P21926; Q5J7W6; Q96ES4" "Vitamin D receptor pathway" "Platelet degranulation ; Uptake and function of diphtheria toxin; Acrosome Reaction and Sperm:Oocyte Membrane Binding" "4" "0" "0.855" "0.965" "0.938" "0.927" "1.037" "0.918" "1.009" "0.873" "0.921" "473.3" "404.8" "456.8" "444.1" "438.8" "490.8" "434.6" "477.7" "413.3" "435.8" "" "" "" "" "" "" "" "" "" "" "443.5" "335.0" "424.1" "343.3" "374.0" "468.9" "397.1" "424.2" "413.3" "419.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5498683654784928386" "False" "High" "IsMasterProtein" "Q99541" "Perilipin-2 OS=Homo sapiens OX=9606 GN=PLIN2 PE=1 SV=2" "0.001" "False" "3.949" "3" "1" "1" "1" "437" "48.0" "6.80" "4.52" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf03036" "123" "ENSG00000147872" "PLIN2" "hsa:123; Q99541; Q9BSC3" "Adipogenesis" "PPARA activates gene expression; Late endosomal microautophagy; Lipophagy; Chaperone Mediated Autophagy" "5" "0" "0.967" "0.944" "0.906" "0.859" "0.857" "0.832" "0.769" "0.938" "0.877" "499.4" "482.8" "471.5" "452.6" "428.9" "428.1" "415.5" "383.9" "468.3" "438.1" "" "" "" "" "" "" "" "" "" "" "468.0" "399.5" "437.7" "349.9" "365.6" "409.0" "379.6" "340.9" "468.3" "421.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8649705542655534815" "False" "High" "IsMasterProtein" "Q8N573" "Oxidation resistance protein 1 OS=Homo sapiens OX=9606 GN=OXR1 PE=1 SV=2" "0.001" "False" "3.947" "1" "1" "1" "1" "874" "97.9" "5.47" "3.67" "1" "stress response;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf01476, Pf07534" "55074" "ENSG00000164830" "OXR1" "A6NK11; A8KA34; B3KXL1; B7Z402; B7Z8N5; D3HIS6; hsa:55074; Q3LIB5; Q6ZVK9; Q8N573; Q8N8V0; Q9H266; Q9NWC7" "" "" "0" "0" "1.203" "1.128" "1.040" "0.964" "1.042" "1.036" "1.164" "1.006" "0.992" "86.4" "103.9" "97.5" "89.9" "83.3" "90.0" "89.5" "100.6" "86.9" "85.8" "" "" "" "" "" "" "" "" "" "" "81.0" "86.0" "90.5" "69.5" "71.0" "86.0" "81.8" "89.3" "86.9" "82.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6012915059673315434" "False" "High" "IsMasterProtein" "Q9UBK8" "Methionine synthase reductase OS=Homo sapiens OX=9606 GN=MTRR PE=1 SV=4" "0.001" "False" "3.947" "2" "1" "1" "1" "698" "77.6" "6.49" "4.29" "1" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00175, Pf00258, Pf00667" "4552" "ENSG00000124275" "MTRR" "hsa:4552; O60471; Q32MA9; Q7Z4M8; Q9UBK8" "Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Male infertility; Spina bifida" "Methylation; Cobalamin (Cbl) metabolism; Sulfur amino acid metabolism; Defective MTRR causes HMAE; Defective MTR causes HMAG" "10" "0" "1.034" "0.940" "1.045" "1.107" "0.901" "1.074" "1.047" "1.021" "1.049" "46.1" "47.6" "43.3" "48.1" "51.0" "41.5" "49.5" "48.2" "47.1" "48.3" "" "" "" "" "" "" "" "" "" "" "43.2" "39.4" "40.2" "37.2" "43.5" "39.7" "45.2" "42.8" "47.1" "46.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3954168667574221268" "False" "High" "IsMasterProtein" "Q9H1J1" "Regulator of nonsense transcripts 3A OS=Homo sapiens OX=9606 GN=UPF3A PE=1 SV=1" "0.001" "False" "3.943" "2" "1" "1" "1" "476" "54.7" "9.03" "4.32" "1" "transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf03467" "65110" "ENSG00000169062" "UPF3A" "A2A366; hsa:65110; Q5T8C3; Q5T8C9; Q7Z6N3; Q86YK1; Q9BZI8; Q9H1J1" "" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "2" "0" "1.136" "1.128" "0.976" "1.116" "1.037" "0.990" "0.941" "0.924" "1.126" "81.0" "92.0" "91.4" "79.1" "90.4" "84.0" "80.2" "76.2" "74.8" "91.2" "" "" "" "" "" "" "" "" "" "" "75.9" "76.1" "84.8" "61.1" "77.0" "80.2" "73.3" "67.7" "74.8" "87.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4278249940828633973" "False" "High" "IsMasterProtein" "P32321" "Deoxycytidylate deaminase OS=Homo sapiens OX=9606 GN=DCTD PE=1 SV=2" "0.001" "False" "3.939" "6" "1" "2" "1" "178" "20.0" "7.56" "8.85" "1" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00383" "1635" "ENSG00000129187" "DCTD" "B2R836; D3DP49; D3DP50; hsa:1635; P32321; Q5M7Z8; Q9BVD8" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7128094865721745487" "False" "High" "IsMasterProtein" "Q9UKL6" "Phosphatidylcholine transfer protein OS=Homo sapiens OX=9606 GN=PCTP PE=1 SV=1" "0.001" "False" "3.937" "8" "2" "2" "2" "214" "24.8" "5.78" "5.23" "2" "transport;other biological processes" "cytosol" "transporter activity;other molecular function" "Pf01852" "58488" "ENSG00000141179" "PCTP" "hsa:58488; Q9BSC9; Q9UIT3; Q9UKL6; Q9UKW7" "" "Mitochondrial Fatty Acid Beta-Oxidation; Synthesis of PC" "2" "0" "1.079" "1.016" "1.169" "1.010" "0.932" "1.141" "1.056" "0.985" "1.104" "140.6" "151.8" "142.8" "164.5" "142.1" "131.0" "160.5" "148.4" "138.5" "155.2" "" "" "" "" "" "" "" "" "" "" "131.8" "125.6" "132.6" "127.1" "121.1" "125.2" "146.6" "131.8" "138.5" "149.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3090856641429635389" "False" "High" "IsMasterProtein" "Q16637" "Survival motor neuron protein OS=Homo sapiens OX=9606 GN=SMN2 PE=1 SV=1" "0.001" "False" "3.937" "6" "1" "1" "1" "294" "31.8" "6.55" "3.14" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06003, Pf20635, Pf20636" "6606; 6607" "ENSG00000172062; ENSG00000205571; ENSG00000273772; ENSG00000275349; ENSG00000277773" "SMN1; SMN2" "A8K0V4; hsa:6606; hsa:6607; Q13119; Q16637; Q549U5; Q96J51" "" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "2" "0" "1.032" "1.022" "1.312" "1.152" "1.082" "1.289" "1.172" "0.939" "1.102" "52.2" "53.9" "53.3" "68.5" "60.1" "56.5" "67.3" "61.2" "49.0" "57.5" "" "" "" "" "" "" "" "" "" "" "48.9" "44.6" "49.5" "52.9" "51.2" "54.0" "61.5" "54.3" "49.0" "55.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3718082725162177882" "False" "High" "IsMasterProtein" "O95822" "Malonyl-CoA decarboxylase, mitochondrial OS=Homo sapiens OX=9606 GN=MLYCD PE=1 SV=3" "0.001" "False" "3.936" "3" "1" "1" "1" "493" "55.0" "8.95" "4.05" "1" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05292, Pf17408" "23417" "ENSG00000103150" "MLYCD" "hsa:23417; O95822; Q9UNU5; Q9Y3F2" "" "" "0" "0" "0.995" "0.953" "1.238" "1.183" "1.105" "1.133" "1.026" "1.039" "1.066" "96.3" "95.8" "91.8" "119.3" "114.0" "106.4" "109.1" "98.9" "100.1" "102.6" "" "" "" "" "" "" "" "" "" "" "90.2" "79.3" "85.2" "92.2" "97.2" "101.7" "99.7" "87.8" "100.1" "98.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6704752873658697689" "False" "High" "IsMasterProtein" "P37268" "Squalene synthase OS=Homo sapiens OX=9606 GN=FDFT1 PE=1 SV=1" "0.001" "False" "3.935" "4" "1" "1" "1" "417" "48.1" "6.54" "4.43" "1" "other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00494" "2222" "ENSG00000079459; ENSG00000284967" "FDFT1" "B3KQ95; B4DJE5; B4DT56; B7Z1J3; hsa:2222; P37268; Q96GT0" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Statin inhibition of cholesterol production; Ferroptosis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism; 8p23.1 copy number variation syndrome" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "12" "0" "1.136" "0.924" "1.072" "0.925" "1.026" "1.115" "0.819" "0.903" "1.192" "28.3" "32.2" "26.2" "30.3" "26.2" "29.0" "31.6" "23.2" "25.6" "33.7" "" "" "" "" "" "" "" "" "" "" "26.5" "26.6" "24.3" "23.4" "22.3" "27.7" "28.8" "20.6" "25.6" "32.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8654405548002230634" "False" "High" "IsMasterProtein" "Q49B96" "Cytochrome c oxidase assembly protein COX19 OS=Homo sapiens OX=9606 GN=COX19 PE=1 SV=1" "0.001" "False" "3.934" "11" "1" "1" "1" "90" "10.4" "8.72" "4.10" "1" "cell organization and biogenesis;other biological processes" "cytosol;mitochondrion" "" "Pf06747" "90639" "ENSG00000240230" "COX19" "A4FTX0; hsa:90639; Q49B96" "Mitochondrial complex IV assembly" "Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes; Mitochondrial protein import" "5" "0" "1.212" "1.059" "1.130" "1.054" "0.976" "1.001" "1.035" "0.909" "1.011" "237.1" "287.5" "251.2" "267.9" "249.9" "231.4" "237.4" "245.3" "215.5" "239.8" "" "" "" "" "" "" "" "" "" "" "222.2" "237.9" "233.2" "207.1" "213.0" "221.1" "216.9" "217.8" "215.5" "230.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2207555378581959897" "False" "High" "IsMasterProtein" "Q14761" "Protein tyrosine phosphatase receptor type C-associated protein OS=Homo sapiens OX=9606 GN=PTPRCAP PE=1 SV=1" "0.001" "False" "3.933" "6" "1" "1" "1" "206" "21.2" "4.55" "4.22" "1" "stress response" "plasma membrane;other membranes" "" "Pf15713" "5790" "ENSG00000213402" "PTPRCAP" "B2R512; hsa:5790; O00643; Q14761; Q6I9S6" "TNF-alpha signaling pathway" "" "1" "0" "1.089" "0.947" "1.103" "1.073" "0.987" "0.983" "1.013" "0.946" "1.016" "131.0" "142.7" "124.0" "144.4" "140.5" "129.3" "128.7" "132.7" "123.9" "133.1" "" "" "" "" "" "" "" "" "" "" "122.7" "118.0" "115.1" "111.7" "119.8" "123.5" "117.6" "117.8" "123.9" "128.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7952691654267697192" "False" "High" "IsMasterProtein" "Q15067" "Peroxisomal acyl-coenzyme A oxidase 1 OS=Homo sapiens OX=9606 GN=ACOX1 PE=1 SV=3" "0.001" "False" "3.933" "2" "2" "5" "2" "660" "74.4" "8.16" "12.94" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;other cytoplasmic organelle" "other molecular function" "Pf01756, Pf02770, Pf14749" "51" "ENSG00000161533" "ACOX1" "A8K6X8; A8KAA0; B4DK61; F5GYQ8; hsa:51; Q12863; Q15067; Q15068; Q15101; Q16131; Q7Z3W5; Q9UD31" "Estrogen receptor pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-3 / omega-6 fatty acid synthesis" "TYSND1 cleaves peroxisomal proteins" "8" "0" "1.048" "1.008" "1.136" "1.046" "1.018" "1.061" "0.985" "0.995" "1.021" "402.6" "421.8" "405.9" "457.5" "421.0" "410.0" "427.3" "396.6" "400.8" "411.2" "" "" "" "" "" "" "" "" "" "" "377.3" "349.0" "376.8" "353.7" "358.9" "391.7" "390.4" "352.1" "400.8" "395.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5814198643835656164" "False" "High" "IsMasterProtein" "O60711" "Leupaxin OS=Homo sapiens OX=9606 GN=LPXN PE=1 SV=1" "0.001" "False" "3.930" "3" "1" "2" "1" "386" "43.3" "6.01" "6.49" "1" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "9404" "ENSG00000110031" "LPXN" "B2R8B4; B4DV71; hsa:9404; O60711; Q53FW6; Q6FI07" "" "" "0" "0" "0.808" "0.955" "1.227" "0.974" "0.869" "1.181" "0.991" "0.792" "0.963" "265.7" "214.6" "253.8" "325.9" "258.8" "230.9" "313.8" "263.4" "210.6" "255.8" "" "" "" "" "" "" "" "" "" "" "249.0" "177.6" "235.6" "251.9" "220.6" "220.6" "286.8" "233.9" "210.6" "246.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8335740267375587213" "False" "High" "IsMasterProtein" "P09132" "Signal recognition particle 19 kDa protein OS=Homo sapiens OX=9606 GN=SRP19 PE=1 SV=3" "0.001" "False" "3.925" "10" "1" "1" "1" "144" "16.1" "9.85" "4.70" "1" "cell organization and biogenesis;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01922" "6728" "ENSG00000153037" "SRP19" "B2R4E9; D6RCQ5; hsa:6728; P09132; Q05D77; Q96FG6" "" "SRP-dependent cotranslational protein targeting to membrane" "1" "0" "1.019" "1.154" "0.978" "0.981" "0.957" "0.953" "1.042" "0.940" "0.932" "143.3" "146.0" "165.4" "140.1" "140.6" "137.1" "136.6" "149.4" "134.7" "133.6" "" "" "" "" "" "" "" "" "" "" "134.3" "120.8" "153.5" "108.3" "119.9" "131.0" "124.8" "132.6" "134.7" "128.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-728646887416176304" "False" "High" "IsMasterProtein" "Q8IYL3" "UPF0688 protein C1orf174 OS=Homo sapiens OX=9606 GN=C1orf174 PE=1 SV=2" "0.001" "False" "3.924" "6" "1" "1" "1" "243" "26.0" "6.90" "3.90" "1" "" "nucleus" "" "Pf15772" "339448" "ENSG00000198912" "C1orf174" "A8K0C8; A8MUG9; hsa:339448; Q5SR20; Q6NX36; Q8IYL3" "" "" "0" "0" "1.065" "1.027" "1.029" "1.036" "1.035" "1.005" "1.071" "1.094" "1.067" "318.6" "339.3" "327.3" "327.8" "329.9" "329.7" "320.2" "341.1" "348.5" "339.9" "" "" "" "" "" "" "" "" "" "" "298.5" "280.8" "303.8" "253.4" "281.2" "315.0" "292.6" "302.9" "348.5" "327.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8889499803111270787" "False" "High" "IsMasterProtein" "O43824" "Putative GTP-binding protein 6 OS=Homo sapiens OX=9606 GN=GTPBP6 PE=1 SV=4" "0.001" "False" "3.921" "2" "1" "1" "1" "516" "56.9" "9.42" "4.23" "1" "" "other cell component" "translation activity;other molecular function" "Pf01926, Pf13167, Pf16360" "8225" "ENSG00000178605; ENSG00000292358" "GTPBP6" "H0Y2S1; hsa:8225; O43824; Q53F77; Q5HYX8" "" "" "0" "0" "1.012" "1.079" "0.996" "0.980" "1.013" "1.046" "0.986" "1.092" "1.087" "210.5" "213.0" "227.1" "209.6" "206.3" "213.2" "220.1" "207.6" "229.8" "228.7" "" "" "" "" "" "" "" "" "" "" "197.2" "176.3" "210.8" "162.1" "175.9" "203.7" "201.2" "184.3" "229.8" "220.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9100987661805535323" "False" "High" "IsMasterProtein" "Q14680" "Maternal embryonic leucine zipper kinase OS=Homo sapiens OX=9606 GN=MELK PE=1 SV=3" "0.001" "False" "3.919" "2" "2" "2" "1" "651" "74.6" "8.72" "6.14" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "kinase activity;other molecular function" "Pf00069, Pf02149, Pf21594" "9833" "ENSG00000165304" "MELK" "A6P3A7; A6P3A8; B1AMQ6; B7Z1E6; B7Z5M5; B7Z6Q7; B7Z6R8; B7Z6Y0; B7Z7Q1; D3DRP8; F5H0Y0; F5H2R4; F5H689; hsa:9833; Q14680; Q7L3C3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5145087697178070665" "False" "High" "IsMasterProtein" "Q9H4I2" "Zinc fingers and homeoboxes protein 3 OS=Homo sapiens OX=9606 GN=ZHX3 PE=1 SV=3" "0.001" "False" "3.916" "2" "1" "1" "1" "956" "104.6" "6.07" "3.39" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf11569, Pf18387" "23051" "ENSG00000174306" "ZHX3" "E1P5W5; F5H820; hsa:23051; O43145; Q6NUJ7; Q9H4I2" "" "" "0" "0" "0.934" "0.911" "1.181" "1.046" "0.846" "0.949" "0.935" "0.862" "1.008" "38.8" "36.2" "35.4" "45.8" "40.6" "32.8" "36.8" "36.3" "33.4" "39.1" "" "" "" "" "" "" "" "" "" "" "36.4" "30.0" "32.8" "35.4" "34.6" "31.4" "33.7" "32.2" "33.4" "37.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7703205907594076097" "False" "High" "IsMasterProtein" "Q12982" "BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 OS=Homo sapiens OX=9606 GN=BNIP2 PE=1 SV=1" "0.001" "False" "3.916" "6" "2" "3" "2" "314" "36.0" "4.81" "6.76" "2" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf12496, Pf13716" "663" "ENSG00000140299" "BNIP2" "B4DS94; hsa:663; Q12982" "Acute viral myocarditis" "Myogenesis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8786307772961790223" "False" "High" "IsMasterProtein" "Q6QNY1" "Biogenesis of lysosome-related organelles complex 1 subunit 2 OS=Homo sapiens OX=9606 GN=BLOC1S2 PE=1 SV=1" "0.001" "False" "3.915" "13" "1" "1" "1" "142" "16.0" "4.86" "5.59" "1" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf10046" "282991" "ENSG00000196072" "BLOC1S2" "B4DQV2; hsa:282991; Q5W040; Q6QNY1; Q8WUI8" "" "" "0" "0" "0.918" "0.941" "0.995" "1.007" "0.892" "0.983" "1.051" "0.870" "1.008" "173.1" "158.9" "162.8" "172.2" "174.3" "154.5" "170.1" "181.9" "150.5" "174.5" "" "" "" "" "" "" "" "" "" "" "162.2" "131.5" "151.2" "133.1" "148.6" "147.6" "155.4" "161.5" "150.5" "168.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "786541619406263347" "False" "High" "IsMasterProtein" "O95243" "Methyl-CpG-binding domain protein 4 OS=Homo sapiens OX=9606 GN=MBD4 PE=1 SV=1" "0.001" "False" "3.913" "3" "2" "2" "2" "580" "66.0" "8.82" "4.47" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01429" "8930" "ENSG00000129071" "MBD4" "B4DZN2; D3DNC3; D3DNC4; E9PEE4; hsa:8930; O95243; Q2MD36; Q7Z4T3; Q96F09" "Base excision repair; DNA repair pathways, full network" "Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Displacement of DNA glycosylase by APEX1" "5" "0" "1.002" "1.053" "1.039" "1.021" "0.932" "0.927" "0.980" "1.048" "0.999" "99.8" "100.0" "105.1" "103.8" "101.9" "93.0" "92.6" "97.8" "104.6" "99.8" "" "" "" "" "" "" "" "" "" "" "93.5" "82.8" "97.6" "80.2" "86.9" "88.9" "84.6" "86.8" "104.6" "96.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9136982351856623934" "False" "High" "IsMasterProtein" "P01861" "Immunoglobulin heavy constant gamma 4 OS=Homo sapiens OX=9606 GN=IGHG4 PE=1 SV=2" "0.001" "False" "3.913" "4" "1" "1" "1" "396" "43.8" "6.24" "3.35" "1" "stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf07654" "" "ENSG00000211892; ENSG00000277016" "IGHG4" "A0A286YFJ8; P01861" "" "Initial triggering of complement; Classical antibody-mediated complement activation; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of Complement cascade; Interleukin-4 and Interleukin-13 signaling" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2764493771843335681" "False" "High" "IsMasterProtein" "P08651" "Nuclear factor 1 C-type OS=Homo sapiens OX=9606 GN=NFIC PE=1 SV=2" "0.001" "False" "3.913" "3" "2" "2" "2" "508" "55.6" "8.38" "4.76" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00859, Pf03165, Pf10524" "4782" "ENSG00000141905" "NFIC" "A8K1H0; B7Z4U5; B7Z9C3; hsa:4782; K7EMU1; P08651; P08652; Q14932; Q9UPJ3; Q9UPJ9; Q9UPK0; Q9UPK1" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination" "2" "0" "0.848" "0.867" "1.036" "0.934" "1.002" "1.059" "0.917" "0.965" "0.918" "159.7" "135.4" "138.4" "165.5" "149.2" "160.0" "169.2" "146.4" "154.1" "146.6" "" "" "" "" "" "" "" "" "" "" "149.7" "112.1" "128.5" "127.9" "127.1" "152.9" "154.6" "130.0" "154.1" "141.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6119392158923177395" "False" "High" "IsMasterProtein" "P12018" "Immunoglobulin iota chain OS=Homo sapiens OX=9606 GN=VPREB1 PE=1 SV=2" "0.001" "False" "3.911" "11" "2" "5" "2" "145" "16.6" "6.76" "13.52" "2" "other biological processes" "non-structural extracellular;ER/Golgi" "" "Pf07686" "7441" "ENSG00000169575" "VPREB1" "B5MCG2; hsa:7441; P12018" "" "Cell surface interactions at the vascular wall" "1" "0" "0.949" "0.895" "0.819" "0.914" "0.976" "0.806" "0.864" "0.947" "0.945" "534.6" "507.5" "478.6" "438.0" "488.5" "521.9" "430.8" "461.6" "506.3" "505.4" "" "" "" "" "" "" "" "" "" "" "500.9" "419.9" "444.3" "338.6" "416.4" "498.7" "393.6" "409.9" "506.3" "486.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4369006210393907159" "False" "High" "IsMasterProtein" "Q16877" "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 OS=Homo sapiens OX=9606 GN=PFKFB4 PE=1 SV=6" "0.001" "False" "3.910" "4" "2" "4" "1" "469" "54.0" "6.62" "8.03" "2" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf00300, Pf01591" "5210" "ENSG00000114268" "PFKFB4" "hsa:5210; Q16877; Q5S3G5; Q5XLC2; Q64EX5" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling" "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" "3" "0" "1.026" "0.957" "0.897" "0.941" "0.973" "0.889" "0.880" "0.882" "0.987" "347.7" "356.9" "332.8" "311.9" "327.1" "338.2" "309.2" "305.9" "306.6" "343.0" "" "" "" "" "" "" "" "" "" "" "325.8" "295.3" "308.9" "241.1" "278.8" "323.1" "282.5" "271.6" "306.6" "330.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5677827102624180499" "False" "High" "IsMasterProtein" "Q96IQ9" "Zinc finger protein 414 OS=Homo sapiens OX=9606 GN=ZNF414 PE=1 SV=2" "0.001" "False" "3.909" "5" "2" "2" "2" "312" "32.8" "7.81" "4.98" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf15909" "84330" "ENSG00000133250" "ZNF414" "A8MY94; hsa:84330; Q96IQ9" "" "" "0" "0" "1.059" "1.077" "1.269" "1.017" "1.135" "1.237" "1.102" "1.130" "1.125" "78.7" "83.4" "84.8" "99.9" "80.1" "89.3" "97.4" "86.7" "89.0" "88.6" "" "" "" "" "" "" "" "" "" "" "73.7" "69.0" "78.7" "77.2" "68.2" "85.3" "89.0" "77.0" "89.0" "85.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4366826834122666967" "False" "High" "IsMasterProtein" "Q92966" "snRNA-activating protein complex subunit 3 OS=Homo sapiens OX=9606 GN=SNAPC3 PE=1 SV=1" "0.001" "False" "3.908" "3" "1" "1" "1" "411" "46.7" "5.27" "3.82" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12251" "6619" "ENSG00000164975" "SNAPC3" "D3DRI8; hsa:6619; Q2VPI6; Q5T285; Q92966" "" "RNA polymerase II transcribes snRNA genes; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter" "3" "0" "1.046" "1.116" "1.154" "1.218" "1.101" "0.928" "0.830" "0.960" "1.036" "127.5" "133.3" "142.2" "147.1" "155.3" "140.3" "118.3" "105.8" "122.4" "132.1" "" "" "" "" "" "" "" "" "" "" "119.4" "110.3" "132.0" "113.7" "132.4" "134.1" "108.1" "94.0" "122.4" "127.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7629831506614287225" "False" "High" "IsMasterProtein" "Q96A47" "Insulin gene enhancer protein ISL-2 OS=Homo sapiens OX=9606 GN=ISL2 PE=1 SV=1" "0.001" "False" "3.908" "5" "1" "1" "1" "359" "39.7" "8.28" "3.34" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00412" "64843" "ENSG00000159556" "ISL2" "B3KM37; hsa:64843; Q96A47" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-572232975925861742" "False" "High" "IsMasterProtein" "P46779" "Large ribosomal subunit protein eL28 OS=Homo sapiens OX=9606 GN=RPL28 PE=1 SV=3" "0.001" "False" "3.905" "8" "1" "1" "1" "137" "15.7" "12.02" "3.66" "1" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01778" "6158" "ENSG00000108107" "RPL28" "B2R4A6; B4DEP9; C9JB50; E9PB24; G5E9L2; hsa:6158; P46779; Q6IAY0; Q96FX1; Q9BWQ0" "Cytoplasmic ribosomal proteins" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.197" "1.090" "1.142" "1.159" "1.087" "1.242" "1.054" "1.074" "1.146" "208.9" "250.1" "227.7" "238.7" "242.1" "227.1" "259.5" "220.2" "224.3" "239.3" "" "" "" "" "" "" "" "" "" "" "195.8" "207.0" "211.4" "184.5" "206.4" "216.9" "237.1" "195.5" "224.3" "230.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8715917564772373095" "False" "High" "IsMasterProtein" "Q9C0B7" "Transport and Golgi organization protein 6 homolog OS=Homo sapiens OX=9606 GN=TANGO6 PE=1 SV=2" "0.001" "False" "3.904" "1" "2" "2" "2" "1094" "120.7" "6.11" "4.67" "2" "transport" "other membranes" "" "Pf10304, Pf10363" "79613" "ENSG00000103047" "TANGO6" "hsa:79613; Q569F9; Q9C0B7; Q9H9K1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3562387644317083347" "False" "High" "IsMasterProtein" "Q8N3C0" "Activating signal cointegrator 1 complex subunit 3 OS=Homo sapiens OX=9606 GN=ASCC3 PE=1 SV=3" "0.001" "False" "3.902" "1" "1" "1" "1" "2202" "251.3" "7.09" "4.15" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf02889" "10973" "ENSG00000112249" "ASCC3" "E7EW23; hsa:10973; O43738; Q4G1A0; Q5VTN2; Q8N3C0; Q9H1I9; Q9H5A2; Q9NTR0" "Mesodermal commitment pathway; VEGFA-VEGFR2 signaling" "ALKBH3 mediated reversal of alkylation damage" "3" "0" "1.002" "0.947" "1.048" "0.966" "0.887" "1.128" "1.045" "0.992" "0.964" "180.4" "180.8" "170.9" "189.0" "174.3" "160.0" "203.5" "188.5" "179.0" "173.8" "" "" "" "" "" "" "" "" "" "" "169.0" "149.6" "158.6" "146.1" "148.5" "152.9" "185.9" "167.4" "179.0" "167.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6048684120117324541" "False" "High" "IsMasterProtein" "Q86VW0" "SEC14 domain and spectrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=SESTD1 PE=1 SV=2" "0.001" "False" "3.899" "1" "1" "1" "1" "696" "79.3" "5.10" "3.53" "1" "other biological processes" "cytoskeleton" "other molecular function" "Pf13716" "91404" "ENSG00000187231" "SESTD1" "hsa:91404; Q53R38; Q53SP3; Q5GM69; Q86VW0; Q8N6M1; Q96LQ2" "" "" "0" "0" "1.061" "1.016" "1.114" "1.105" "1.057" "1.074" "0.992" "0.945" "1.002" "208.8" "221.4" "212.0" "232.6" "230.7" "220.7" "224.3" "207.2" "197.3" "209.2" "" "" "" "" "" "" "" "" "" "" "195.6" "183.2" "196.8" "179.8" "196.7" "210.9" "205.0" "183.9" "197.3" "201.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2744059212078180576" "False" "High" "IsMasterProtein" "P17029" "Zinc finger protein with KRAB and SCAN domains 1 OS=Homo sapiens OX=9606 GN=ZKSCAN1 PE=1 SV=3" "0.001" "False" "3.896" "2" "1" "1" "1" "563" "63.6" "7.05" "3.90" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352, Pf02023" "7586" "ENSG00000106261" "ZKSCAN1" "A4D294; hsa:7586; P17029; P52745; Q2M1U1; Q8TBW5; Q8TEK7" "" "Generic Transcription Pathway" "1" "0" "1.117" "0.984" "1.034" "0.955" "1.060" "0.917" "0.678" "0.732" "0.956" "112.5" "125.6" "110.7" "116.4" "107.5" "119.3" "103.1" "76.2" "82.4" "107.6" "" "" "" "" "" "" "" "" "" "" "105.4" "103.9" "102.8" "90.0" "91.6" "114.0" "94.2" "67.7" "82.4" "103.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4939449039103849626" "False" "High" "IsMasterProtein" "Q96G74" "OTU domain-containing protein 5 OS=Homo sapiens OX=9606 GN=OTUD5 PE=1 SV=1" "0.001" "False" "3.895" "3" "1" "1" "1" "571" "60.6" "6.54" "3.34" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf02338" "55593" "ENSG00000068308; ENSG00000292211" "OTUD5" "B4DGG7; G5E9D7; hsa:55593; Q4KMN9; Q8N6T5; Q96G74; Q9H650; Q9H9U0; Q9NT65" "Gastric cancer network 2; Novel intracellular components of RIG-I-like receptor pathway" "Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases" "4" "0" "0.999" "0.973" "1.176" "0.899" "0.965" "1.201" "1.070" "0.944" "0.934" "48.2" "48.1" "46.8" "56.6" "43.3" "46.4" "57.9" "51.5" "45.4" "45.0" "" "" "" "" "" "" "" "" "" "" "45.1" "39.8" "43.5" "43.8" "36.9" "44.4" "52.9" "45.7" "45.4" "43.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4334556934018890015" "False" "High" "IsMasterProtein" "P51808" "Dynein light chain Tctex-type 3 OS=Homo sapiens OX=9606 GN=DYNLT3 PE=1 SV=1" "0.001" "False" "3.894" "15" "1" "1" "1" "116" "13.1" "5.66" "5.11" "1" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03645" "6990" "ENSG00000165169" "DYNLT3" "hsa:6990; P51808; Q6ICS3" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome; Orexin receptor pathway" "" "4" "0" "0.907" "0.947" "1.086" "1.032" "1.051" "0.961" "1.017" "1.065" "0.981" "121.1" "109.9" "114.6" "131.6" "124.9" "127.3" "116.3" "123.2" "129.0" "118.8" "" "" "" "" "" "" "" "" "" "" "113.5" "90.9" "106.4" "101.7" "106.5" "121.7" "106.3" "109.4" "129.0" "114.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8857109262484176384" "False" "High" "IsMasterProtein" "Q16342" "Programmed cell death protein 2 OS=Homo sapiens OX=9606 GN=PDCD2 PE=1 SV=2" "0.001" "False" "3.894" "6" "2" "2" "2" "344" "38.6" "5.38" "3.04" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01753, Pf04194" "5134" "ENSG00000071994" "PDCD2" "E9PCU7; F5GYS7; hsa:5134; Q16342; Q58HM9; Q58HN0; Q9UH12" "" "" "0" "0" "1.178" "1.116" "1.111" "1.053" "1.172" "1.136" "1.065" "1.165" "1.159" "76.5" "90.2" "85.4" "85.0" "80.6" "89.7" "86.9" "81.5" "89.1" "88.7" "" "" "" "" "" "" "" "" "" "" "71.7" "74.6" "79.3" "65.7" "68.7" "85.7" "79.4" "72.4" "89.1" "85.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5390707735378390925" "False" "High" "IsMasterProtein" "Q8IYB3" "Serine/arginine repetitive matrix protein 1 OS=Homo sapiens OX=9606 GN=SRRM1 PE=1 SV=2" "0.001" "False" "3.893" "2" "1" "1" "1" "904" "102.3" "11.84" "3.72" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf01480" "10250" "ENSG00000133226" "SRRM1" "hsa:10250; O60585; Q5VVN4; Q8IYB3" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "7" "0" "1.022" "1.051" "1.238" "1.138" "1.025" "1.097" "1.063" "1.050" "0.974" "174.7" "178.7" "183.7" "216.3" "198.8" "179.0" "191.7" "185.7" "183.5" "170.2" "" "" "" "" "" "" "" "" "" "" "163.7" "147.8" "170.5" "167.2" "169.4" "171.1" "175.1" "164.9" "183.5" "163.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8369123714013872102" "False" "High" "IsMasterProtein" "Q07065" "Cytoskeleton-associated protein 4 OS=Homo sapiens OX=9606 GN=CKAP4 PE=1 SV=2" "0.001" "False" "3.884" "2" "2" "2" "1" "602" "66.0" "5.92" "4.39" "2" "" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "" "" "10970" "ENSG00000136026" "CKAP4" "hsa:10970; Q07065; Q504S5; Q53ES6" "" "Neutrophil degranulation; RND2 GTPase cycle; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; RND3 GTPase cycle; Surfactant metabolism" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2339365815424834793" "False" "High" "IsMasterProtein" "Q9Y217" "Myotubularin-related protein 6 OS=Homo sapiens OX=9606 GN=MTMR6 PE=1 SV=3" "0.001" "False" "3.882" "2" "1" "1" "1" "621" "71.9" "7.66" "3.96" "1" "protein metabolism;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06602, Pf21098" "9107" "ENSG00000139505" "MTMR6" "B2RBB5; B3KSB4; hsa:9107; Q5JRG6; Q86TB7; Q86YH4; Q96P80; Q9Y217" "8p23.1 copy number variation syndrome" "Synthesis of PIPs at the plasma membrane" "2" "0" "1.105" "1.166" "1.190" "1.172" "1.127" "1.138" "1.045" "1.049" "1.095" "169.5" "187.3" "197.7" "201.8" "198.7" "191.0" "192.9" "177.2" "177.8" "185.6" "" "" "" "" "" "" "" "" "" "" "158.9" "155.0" "183.5" "156.0" "169.4" "182.5" "176.2" "157.3" "177.8" "178.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2668424523932492370" "False" "High" "IsMasterProtein" "Q9BVQ7" "ATPase family gene 2 protein homolog B OS=Homo sapiens OX=9606 GN=AFG2B PE=1 SV=2" "0.001" "False" "3.881" "1" "1" "1" "1" "753" "80.7" "8.09" "3.67" "1" "other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00004, Pf17862" "79029" "ENSG00000171763" "AFG2B" "C9JHR5; hsa:79029; Q9BVQ7; Q9H8W7; Q9HA41" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-386801928701098306" "False" "High" "IsMasterProtein" "Q6ULP2" "Aftiphilin OS=Homo sapiens OX=9606 GN=AFTPH PE=1 SV=3" "0.001" "False" "3.878" "2" "1" "1" "1" "936" "102.1" "4.54" "2.96" "1" "transport" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf15045" "54812" "ENSG00000119844" "AFTPH" "D6W5E9; hsa:54812; Q6ULP2; Q6ZM66; Q86VW3; Q8TCF3; Q9H7E3; Q9HAB9; Q9NXS4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7379304699154124017" "False" "High" "IsMasterProtein" "Q7Z7C8" "Transcription initiation factor TFIID subunit 8 OS=Homo sapiens OX=9606 GN=TAF8 PE=1 SV=1" "0.001" "False" "3.877" "3" "1" "1" "1" "310" "34.2" "6.46" "3.87" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf07524, Pf10406" "129685" "ENSG00000137413" "TAF8" "hsa:129685; Q5T0K1; Q7Z7C8; Q8N4R9; Q96M52" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3327370381573557729" "False" "High" "IsMasterProtein" "Q99611" "Selenide, water dikinase 2 OS=Homo sapiens OX=9606 GN=SEPHS2 PE=1 SV=3" "0.001" "False" "3.877" "3" "2" "2" "1" "448" "47.3" "5.88" "5.81" "2" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00586, Pf02769" "22928" "ENSG00000179918" "SEPHS2" "hsa:22928; Q99611; Q9BUQ2" "Selenium micronutrient network; Selenium metabolism and selenoproteins" "Selenocysteine synthesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4643888973216991338" "False" "High" "IsMasterProtein" "Q9Y4F3" "Meiosis regulator and mRNA stability factor 1 OS=Homo sapiens OX=9606 GN=MARF1 PE=1 SV=6" "0.001" "False" "3.877" "1" "2" "2" "2" "1742" "192.7" "7.87" "5.92" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf01936, Pf11608, Pf12872, Pf19687" "9665" "ENSG00000166783; ENSG00000277140" "MARF1" "A8MSK2; B2RNX2; B4DYY9; B7ZMG1; B7ZMG2; F8VV09; hsa:9665; Q6P1R6; Q8WYR2; Q9Y4F3; Q9Y4J9" "" "" "0" "0" "1.069" "1.039" "1.184" "1.059" "1.147" "1.121" "1.045" "1.043" "1.054" "381.1" "407.2" "395.9" "451.2" "403.4" "437.0" "427.1" "398.1" "397.4" "401.5" "" "" "" "" "" "" "" "" "" "" "357.1" "336.9" "367.5" "348.8" "343.9" "417.5" "390.3" "353.5" "397.4" "386.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8565728270651974122" "False" "High" "IsMasterProtein" "Q6PCT2" "F-box/LRR-repeat protein 19 OS=Homo sapiens OX=9606 GN=FBXL19 PE=1 SV=3" "0.001" "False" "3.877" "2" "1" "1" "1" "694" "75.7" "9.17" "3.76" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02008, Pf12937, Pf16866" "54620" "ENSG00000099364" "FBXL19" "A8MT10; hsa:54620; Q6PCT2; Q8N789; Q9NT14" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "0.904" "0.889" "1.023" "1.021" "0.896" "0.927" "0.851" "0.898" "0.852" "140.1" "126.7" "124.6" "143.3" "143.0" "125.6" "129.9" "119.2" "125.9" "119.4" "" "" "" "" "" "" "" "" "" "" "131.3" "104.9" "115.7" "110.8" "121.9" "120.0" "118.7" "105.8" "125.9" "115.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5399791769626457574" "False" "High" "IsMasterProtein" "Q9UMS0" "NFU1 iron-sulfur cluster scaffold homolog, mitochondrial OS=Homo sapiens OX=9606 GN=NFU1 PE=1 SV=2" "0.001" "False" "3.872" "6" "1" "1" "1" "254" "28.4" "5.07" "4.79" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf01106, Pf08712" "27247" "ENSG00000169599" "NFU1" "B4DUL9; hsa:27247; Q53QE5; Q6VNZ8; Q7Z5B1; Q7Z5B2; Q9UMS0; Q9Y322" "Iron-sulfur cluster biogenesis" "" "1" "0" "1.026" "0.919" "0.843" "0.930" "1.129" "0.909" "1.052" "1.030" "0.964" "164.2" "168.5" "151.0" "138.4" "152.8" "185.4" "149.2" "172.7" "169.0" "158.3" "" "" "" "" "" "" "" "" "" "" "153.8" "139.5" "140.1" "107.0" "130.2" "177.1" "136.4" "153.3" "169.0" "152.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8502957251701712576" "False" "High" "IsMasterProtein" "Q9UHW5" "GPN-loop GTPase 3 OS=Homo sapiens OX=9606 GN=GPN3 PE=1 SV=2" "0.001" "False" "3.871" "5" "1" "1" "1" "284" "32.7" "4.50" "3.53" "1" "" "other cell component" "other molecular function" "Pf03029" "51184" "ENSG00000111231" "GPN3" "B2RC54; D4YWV1; F5H759; hsa:51184; Q53FS3; Q6UVZ6; Q7Z3D3; Q8NEI2; Q96HK9; Q9UHW5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3580495926751523962" "False" "High" "IsMasterProtein" "Q5T7W0" "Zinc finger protein 618 OS=Homo sapiens OX=9606 GN=ZNF618 PE=1 SV=1" "0.001" "False" "3.871" "2" "1" "1" "1" "954" "104.9" "7.09" "3.65" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "114991" "ENSG00000157657" "ZNF618" "B9EG82; hsa:114991; Q4G0X6; Q5T7W0; Q5T7W1; Q6ZT53; Q7Z6B9; Q8TF49; Q96E49" "" "" "0" "0" "1.007" "0.998" "0.955" "1.007" "0.997" "0.938" "0.938" "0.950" "0.923" "238.8" "240.4" "238.4" "228.1" "240.4" "238.2" "223.9" "224.0" "226.9" "220.3" "" "" "" "" "" "" "" "" "" "" "223.8" "198.9" "221.3" "176.3" "204.9" "227.5" "204.6" "198.9" "226.9" "212.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "157541479094675987" "False" "High" "IsMasterProtein" "Q96AB3" "Isochorismatase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ISOC2 PE=1 SV=1" "0.001" "False" "3.870" "7" "1" "1" "1" "205" "22.3" "7.77" "5.05" "1" "other biological processes" "nucleus;other cell component" "" "Pf00857" "79763" "ENSG00000063241" "ISOC2" "hsa:79763; Q6ZN91; Q96AB3; Q9H5G0" "" "" "0" "0" "1.248" "1.135" "1.109" "1.417" "1.307" "1.219" "1.041" "1.318" "1.230" "136.3" "170.1" "154.7" "151.2" "193.1" "178.1" "166.2" "141.9" "179.6" "167.7" "" "" "" "" "" "" "" "" "" "" "127.7" "140.8" "143.6" "116.9" "164.6" "170.2" "151.9" "126.0" "179.6" "161.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1858291838725637521" "False" "High" "IsMasterProtein" "Q14353" "Guanidinoacetate N-methyltransferase OS=Homo sapiens OX=9606 GN=GAMT PE=1 SV=1" "0.001" "False" "3.870" "9" "1" "1" "1" "236" "26.3" "6.14" "4.19" "1" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "" "2593" "ENSG00000130005" "GAMT" "A8K0A0; hsa:2593; Q14353; Q53Y34; Q8WVJ1" "MECP2 and associated Rett syndrome; Creatine pathway" "Transcriptional Regulation by MECP2; Creatine metabolism" "4" "0" "1.409" "0.945" "1.256" "0.957" "1.036" "1.376" "0.893" "0.957" "1.230" "27.0" "38.1" "25.6" "34.0" "25.9" "28.0" "37.2" "24.2" "25.9" "33.3" "" "" "" "" "" "" "" "" "" "" "25.3" "31.5" "23.7" "26.3" "22.1" "26.8" "34.0" "21.5" "25.9" "32.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5731333323507382333" "False" "High" "IsMasterProtein" "Q8NB78" "Lysine-specific histone demethylase 2 OS=Homo sapiens OX=9606 GN=KDM1B PE=1 SV=3" "0.001" "False" "3.864" "2" "2" "2" "2" "822" "92.0" "7.87" "4.98" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01593, Pf04433, Pf07496" "221656" "ENSG00000165097" "KDM1B" "A2A2C5; A2A2C6; hsa:221656; Q5TGV3; Q6AI15; Q6ZUU4; Q8N258; Q8NB78; Q96EL7" "Vitamin D-sensitive calcium signaling in depression" "UCH proteinases; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5259083941231079932" "False" "High" "IsMasterProtein" "Q7Z4G1" "COMM domain-containing protein 6 OS=Homo sapiens OX=9606 GN=COMMD6 PE=1 SV=1" "0.001" "False" "3.863" "21" "2" "3" "2" "85" "9.6" "6.00" "6.81" "2" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf07258" "170622" "ENSG00000188243" "COMMD6" "A6NF28; B7ZLN0; hsa:170622; Q5TBK4; Q7Z4G1" "" "Neddylation" "1" "0" "1.124" "0.948" "1.115" "0.986" "0.876" "1.084" "1.020" "0.974" "1.045" "162.3" "182.4" "153.8" "180.9" "159.9" "142.1" "175.9" "165.5" "158.1" "169.6" "" "" "" "" "" "" "" "" "" "" "152.0" "151.0" "142.7" "139.8" "136.3" "135.8" "160.8" "147.0" "158.1" "163.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3660276496901993886" "False" "High" "IsMasterProtein" "Q96SY0" "Integrator complex subunit 14 OS=Homo sapiens OX=9606 GN=INTS14 PE=1 SV=2" "0.001" "False" "3.863" "3" "2" "2" "2" "518" "57.4" "5.12" "4.81" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf13519, Pf19435, Pf20504" "81556" "ENSG00000138614" "INTS14" "B4DDI6; B4DVD5; hsa:81556; Q49AH8; Q96HX5; Q96SY0; Q9H0S5" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "0.886" "0.973" "0.966" "0.950" "0.919" "0.982" "0.950" "0.883" "0.928" "234.2" "207.4" "227.8" "226.1" "222.4" "215.3" "230.1" "222.6" "206.8" "217.4" "" "" "" "" "" "" "" "" "" "" "219.4" "171.6" "211.5" "174.8" "189.6" "205.7" "210.2" "197.6" "206.8" "209.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2438255133986472284" "False" "High" "IsMasterProtein" "Q9H8H0" "Nucleolar protein 11 OS=Homo sapiens OX=9606 GN=NOL11 PE=1 SV=1" "0.001" "False" "3.863" "2" "1" "1" "1" "719" "81.1" "6.07" "3.68" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf08168, Pf20998" "25926" "ENSG00000130935" "NOL11" "B7Z5V9; hsa:25926; Q7L5S1; Q9H8H0; Q9UG18" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2247702318764912013" "False" "High" "IsMasterProtein" "Q8NI22" "Multiple coagulation factor deficiency protein 2 OS=Homo sapiens OX=9606 GN=MCFD2 PE=1 SV=1" "0.001" "False" "3.863" "9" "1" "2" "1" "146" "16.4" "4.63" "6.69" "1" "transport" "other membranes;ER/Golgi" "other molecular function" "Pf13499" "90411" "ENSG00000180398" "MCFD2" "A8K7W2; D6W5A9; E9PD95; hsa:90411; Q53SS3; Q68D61; Q8N3M5; Q8NI22" "" "COPII-mediated vesicle transport; Cargo concentration in the ER; Transport to the Golgi and subsequent modification" "3" "0" "1.041" "1.141" "0.970" "1.134" "1.097" "1.072" "1.144" "1.160" "1.118" "196.1" "204.2" "223.7" "190.1" "222.3" "215.1" "210.2" "224.4" "227.4" "219.2" "" "" "" "" "" "" "" "" "" "" "183.7" "169.0" "207.7" "147.0" "189.5" "205.5" "192.1" "199.2" "227.4" "211.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4999747194437679436" "False" "High" "IsMasterProtein" "Q969M7" "NEDD8-conjugating enzyme UBE2F OS=Homo sapiens OX=9606 GN=UBE2F PE=1 SV=1" "0.001" "False" "3.863" "5" "1" "1" "1" "185" "21.1" "6.79" "3.47" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179" "140739" "ENSG00000184182" "UBE2F" "A8K1Z8; B4DDT9; B4DFI1; B4DMK3; B4DZU2; B8ZZG2; C9J212; H9KVB9; Q969M7" "2q37 copy number variation syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8316200197019601200" "False" "High" "IsMasterProtein" "Q9Y3I1" "F-box only protein 7 OS=Homo sapiens OX=9606 GN=FBXO7 PE=1 SV=1" "0.001" "False" "3.856" "3" "1" "1" "1" "522" "58.5" "6.55" "2.99" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00646, Pf11566" "25793" "ENSG00000100225" "FBXO7" "B4DNB3; B4DWX5; hsa:25793; Q5TGC4; Q5TI86; Q96HM6; Q9UF21; Q9UKT2; Q9Y3I1" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2668394544474588816" "False" "High" "IsMasterProtein" "Q99470" "Stromal cell-derived factor 2 OS=Homo sapiens OX=9606 GN=SDF2 PE=1 SV=2" "0.001" "False" "3.850" "7" "2" "4" "2" "211" "23.0" "7.33" "2.34" "2" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf02815" "6388" "ENSG00000132581" "SDF2" "hsa:6388; Q99470; Q9BQ79" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "96536570714027089" "False" "High" "IsMasterProtein" "Q99728" "BRCA1-associated RING domain protein 1 OS=Homo sapiens OX=9606 GN=BARD1 PE=1 SV=2" "0.001" "False" "3.849" "3" "2" "2" "2" "777" "86.6" "8.72" "5.19" "2" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00023, Pf00533, Pf14835" "580" "ENSG00000138376" "BARD1" "F6MDH7; F6MDH8; F6MDH9; hsa:580; O43574; Q53SS5; Q99728" "Retinoblastoma gene in cancer; Pleural mesothelioma; 5q35 copy number variation" "UCH proteinases; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Metalloprotease DUBs; Processing of DNA double-strand break ends; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Defective DNA double strand break response due to BRCA1 loss of function; Defective DNA double strand break response due to BARD1 loss of function" "23" "0" "0.972" "1.007" "1.073" "1.002" "0.993" "0.998" "0.992" "0.960" "0.982" "170.7" "165.9" "171.9" "183.1" "171.1" "169.5" "170.4" "169.4" "163.8" "167.6" "" "" "" "" "" "" "" "" "" "" "159.9" "137.3" "159.6" "141.6" "145.8" "162.0" "155.7" "150.4" "163.8" "161.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8494734003636031426" "False" "High" "IsMasterProtein" "Q8N2Z9" "Centromere protein S OS=Homo sapiens OX=9606 GN=CENPS PE=1 SV=1" "0.001" "False" "3.849" "8" "1" "1" "1" "138" "15.9" "6.05" "4.22" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15630" "100526739; 378708" "ENSG00000175279" "CENPS" "hsa:100526739; hsa:378708; Q8N2Z9; Q8NFE5; Q8NFG5" "DNA repair pathways, full network" "Fanconi Anemia Pathway; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PKR-mediated signaling; Deposition of new CENPA-containing nucleosomes at the centromere" "10" "0" "0.942" "1.024" "0.921" "0.976" "1.078" "0.942" "1.041" "1.022" "1.044" "606.9" "571.8" "621.8" "559.1" "592.6" "654.2" "571.6" "631.9" "620.5" "633.9" "" "" "" "" "" "" "" "" "" "" "568.7" "473.1" "577.2" "432.2" "505.1" "625.0" "522.3" "561.1" "620.5" "610.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2767038677570436707" "False" "High" "IsMasterProtein" "P82663" "Small ribosomal subunit protein mS25 OS=Homo sapiens OX=9606 GN=MRPS25 PE=1 SV=1" "0.001" "False" "3.848" "10" "1" "1" "1" "173" "20.1" "8.82" "4.26" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf05047" "64432" "ENSG00000131368" "MRPS25" "B4DFJ5; B4DQG6; hsa:64432; P82663; Q9H7P5" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.035" "0.998" "1.060" "1.011" "1.006" "0.994" "0.952" "0.989" "0.873" "106.2" "109.9" "106.0" "112.5" "107.4" "106.8" "105.6" "101.1" "105.0" "92.7" "" "" "" "" "" "" "" "" "" "" "99.5" "91.0" "98.4" "87.0" "91.5" "102.1" "96.5" "89.8" "105.0" "89.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8452486629110953776" "False" "High" "IsMasterProtein" "Q9BVC6" "Voltage-gated monoatomic cation channel TMEM109 OS=Homo sapiens OX=9606 GN=TMEM109 PE=1 SV=1" "0.001" "False" "3.848" "5" "1" "1" "1" "243" "26.2" "10.48" "3.34" "1" "stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus" "transporter activity" "Pf14965" "79073" "ENSG00000110108" "TMEM109" "hsa:79073; Q9BVC6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3086265819139452668" "False" "High" "IsMasterProtein" "O14773" "Tripeptidyl-peptidase 1 OS=Homo sapiens OX=9606 GN=TPP1 PE=1 SV=2" "0.001" "False" "3.842" "2" "1" "1" "1" "563" "61.2" "6.48" "3.94" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00082, Pf09286" "1200" "ENSG00000166340" "TPP1" "hsa:1200; O14773; Q53HT1; Q5JAK6; Q6UX56; Q71JP6; Q96C37" "VEGFA-VEGFR2 signaling" "XBP1(S) activates chaperone genes" "2" "0" "1.110" "1.103" "1.208" "1.110" "1.092" "1.147" "1.089" "1.118" "1.115" "81.8" "90.7" "90.2" "98.8" "90.8" "89.3" "93.8" "89.0" "91.4" "91.2" "" "" "" "" "" "" "" "" "" "" "76.6" "75.1" "83.8" "76.4" "77.4" "85.3" "85.7" "79.0" "91.4" "87.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-681264021479327249" "False" "High" "IsMasterProtein" "O95396" "Adenylyltransferase and sulfurtransferase MOCS3 OS=Homo sapiens OX=9606 GN=MOCS3 PE=1 SV=1" "0.001" "False" "3.837" "3" "1" "1" "1" "460" "49.6" "6.21" "4.15" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00581, Pf00899" "27304" "ENSG00000124217" "MOCS3" "hsa:27304; O95396" "Metabolic Epileptic Disorders" "Molybdenum cofactor biosynthesis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1957491016862499710" "False" "High" "IsMasterProtein" "P13073" "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Homo sapiens OX=9606 GN=COX4I1 PE=1 SV=1" "0.001" "False" "3.830" "11" "2" "2" "2" "169" "19.6" "9.51" "4.90" "2" "other metabolic processes;transport" "other membranes;cytosol;mitochondrion;nucleus" "transporter activity" "Pf02936" "1327" "ENSG00000131143" "COX4I1" "B2R4J2; D3DUM7; hsa:1327; P13073; Q6P666" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial protein degradation" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6750533820938238159" "False" "High" "IsMasterProtein" "O75943" "Cell cycle checkpoint protein RAD17 OS=Homo sapiens OX=9606 GN=RAD17 PE=1 SV=2" "0.001" "False" "3.830" "2" "2" "2" "2" "681" "77.0" "7.06" "6.05" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03215" "5884" "ENSG00000152942; ENSG00000276618" "RAD17" "A8K8X2; D3DWA5; hsa:5884; O75714; O75943; Q7Z3S4; Q9UNK7; Q9UNR7; Q9UNR8; Q9UPF5" "miRNA regulation of DNA damage response; Gastric cancer network 2; DNA damage response" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "10" "0" "0.918" "0.947" "1.182" "1.046" "1.049" "1.044" "1.054" "0.952" "0.997" "193.1" "177.3" "182.8" "228.3" "201.9" "202.5" "201.6" "203.5" "183.9" "192.5" "" "" "" "" "" "" "" "" "" "" "180.9" "146.7" "169.7" "176.5" "172.1" "193.4" "184.2" "180.7" "183.9" "185.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6709781459489319409" "False" "High" "IsMasterProtein" "Q9UHN1" "DNA polymerase subunit gamma-2 OS=Homo sapiens OX=9606 GN=POLG2 PE=1 SV=1" "0.001" "False" "3.829" "2" "1" "2" "1" "485" "54.9" "8.35" "7.35" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf03129" "11232" "ENSG00000256525" "POLG2" "hsa:11232; O00419; Q0IJ81; Q96GW2; Q9UHN1; Q9UK35; Q9UK94" "" "Transcriptional activation of mitochondrial biogenesis" "1" "0" "1.177" "1.062" "1.158" "1.138" "1.005" "1.127" "1.091" "0.926" "1.072" "415.0" "488.4" "440.9" "480.8" "472.1" "417.0" "467.7" "453.0" "384.4" "444.9" "" "" "" "" "" "" "" "" "" "" "388.9" "404.1" "409.3" "371.7" "402.4" "398.4" "427.3" "402.2" "384.4" "428.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-265901885640742242" "False" "High" "IsMasterProtein" "Q03164" "Histone-lysine N-methyltransferase 2A OS=Homo sapiens OX=9606 GN=KMT2A PE=1 SV=5" "0.001" "False" "3.822" "1" "2" "2" "2" "3969" "431.5" "9.09" "2.92" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf00856, Pf02008, Pf05964, Pf05965, Pf13771" "4297" "ENSG00000118058" "KMT2A" "E9PQG7; hsa:4297; Q03164; Q13743; Q13744; Q14845; Q16364; Q59FF2; Q6UBD1; Q9HBJ3; Q9UD94; Q9UMA3" "Histone modifications" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of WDR5-containing histone-modifying complexes; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Transcriptional regulation of granulopoiesis" "6" "0" "1.019" "1.063" "1.002" "1.081" "1.041" "1.185" "1.042" "1.067" "1.060" "146.3" "149.1" "155.5" "146.7" "158.1" "152.4" "173.4" "152.5" "156.1" "155.1" "" "" "" "" "" "" "" "" "" "" "137.1" "123.4" "144.4" "113.4" "134.8" "145.6" "158.5" "135.4" "156.1" "149.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "121458031031999340" "False" "High" "IsMasterProtein" "P35232" "Prohibitin 1 OS=Homo sapiens OX=9606 GN=PHB1 PE=1 SV=1" "0.001" "False" "3.820" "8" "2" "2" "2" "272" "29.8" "5.76" "2.47" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01145" "5245" "ENSG00000167085" "PHB1" "B4DY47; hsa:5245; P35232; Q4VBQ0" "" "RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Processing of SMDT1" "5" "0" "1.053" "0.984" "1.305" "1.019" "1.102" "1.280" "1.042" "1.006" "0.961" "74.3" "78.2" "73.1" "96.9" "75.7" "81.8" "95.1" "77.4" "74.7" "71.4" "" "" "" "" "" "" "" "" "" "" "69.6" "64.7" "67.9" "74.9" "64.5" "78.2" "86.9" "68.7" "74.7" "68.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3447640502128280284" "False" "High" "IsMasterProtein" "Q9C098" "Serine/threonine-protein kinase DCLK3 OS=Homo sapiens OX=9606 GN=DCLK3 PE=1 SV=2" "0.001" "False" "3.819" "3" "2" "3" "1" "648" "73.8" "8.84" "7.07" "2" "other metabolic processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "85443" "ENSG00000163673" "DCLK3" "hsa:85443; Q9C098" "" "" "0" "0" "0.965" "0.937" "1.343" "1.135" "1.057" "1.056" "1.195" "0.984" "1.049" "61.8" "59.6" "57.9" "82.9" "70.1" "65.3" "65.2" "73.8" "60.8" "64.8" "" "" "" "" "" "" "" "" "" "" "57.9" "49.3" "53.8" "64.1" "59.8" "62.4" "59.6" "65.5" "60.8" "62.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4559140579210949167" "False" "High" "IsMasterProtein" "P62917" "Large ribosomal subunit protein uL2 OS=Homo sapiens OX=9606 GN=RPL8 PE=1 SV=2" "0.001" "False" "3.817" "7" "2" "2" "2" "257" "28.0" "11.03" "5.22" "2" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00181, Pf03947" "6132" "ENSG00000161016" "RPL8" "A8K094; D3DWN2; hsa:6132; P25120; P62917; Q567Q7; Q969V7; Q9BWQ9" "Cytoplasmic ribosomal proteins" "Protein hydroxylation; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.051" "1.007" "1.181" "1.184" "1.031" "1.377" "1.049" "1.030" "1.189" "153.7" "161.4" "154.7" "181.4" "181.9" "158.5" "211.7" "161.3" "158.2" "182.7" "" "" "" "" "" "" "" "" "" "" "144.0" "133.6" "143.6" "140.3" "155.0" "151.4" "193.4" "143.2" "158.2" "176.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7723203762439641288" "False" "High" "IsMasterProtein" "Q9Y5N5" "Methyltransferase N6AMT1 OS=Homo sapiens OX=9606 GN=N6AMT1 PE=1 SV=4" "0.001" "False" "3.816" "5" "1" "1" "1" "214" "22.9" "5.11" "3.19" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05175" "29104" "ENSG00000156239" "N6AMT1" "B2RA97; hsa:29104; Q96F73; Q9Y5N5" "" "Eukaryotic Translation Termination; Methylation" "2" "0" "0.959" "0.882" "0.938" "0.954" "0.933" "0.926" "0.912" "0.916" "0.885" "286.8" "275.0" "253.0" "268.9" "273.7" "267.5" "265.6" "261.5" "262.7" "253.7" "" "" "" "" "" "" "" "" "" "" "268.7" "227.5" "234.9" "207.9" "233.3" "255.6" "242.7" "232.2" "262.7" "244.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2991903496179440797" "False" "High" "IsMasterProtein" "A8CG34" "Nuclear envelope pore membrane protein POM 121C OS=Homo sapiens OX=9606 GN=POM121C PE=1 SV=3" "0.001" "False" "3.815" "1" "2" "2" "2" "1229" "125.0" "10.37" "5.29" "2" "transport" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf15229" "" "ENSG00000272391" "POM121C" "A0A075B7F8; A0A087WY75; A8CG34; O75115; Q9Y2N3; Q9Y4S7" "" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "28" "0" "1.029" "1.257" "1.218" "1.246" "1.352" "1.432" "1.160" "1.252" "1.230" "182.0" "187.2" "228.8" "221.7" "226.8" "246.0" "260.6" "211.1" "227.9" "223.9" "" "" "" "" "" "" "" "" "" "" "170.5" "154.9" "212.4" "171.4" "193.4" "235.1" "238.1" "187.5" "227.9" "215.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2516150800733119915" "False" "High" "IsMasterProtein" "P55011" "Solute carrier family 12 member 2 OS=Homo sapiens OX=9606 GN=SLC12A2 PE=1 SV=1" "0.001" "False" "3.814" "2" "1" "1" "1" "1212" "131.4" "6.40" "4.29" "1" "cell-cell signaling;cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;other molecular function" "Pf00324, Pf03522, Pf08403" "6558" "ENSG00000064651" "SLC12A2" "hsa:6558; P55011; Q8N713; Q8WWH7" "Polycystic kidney disease pathway" "Cation-coupled Chloride cotransporters" "2" "0" "1.174" "1.141" "1.501" "1.261" "1.332" "1.250" "1.079" "1.086" "1.185" "67.5" "79.2" "77.0" "101.3" "85.1" "89.9" "84.4" "72.8" "73.3" "80.0" "" "" "" "" "" "" "" "" "" "" "63.2" "65.6" "71.5" "78.3" "72.5" "85.9" "77.1" "64.6" "73.3" "77.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7346476942521402077" "False" "High" "IsMasterProtein" "Q9BUT9" "MAPK regulated corepressor interacting protein 2 OS=Homo sapiens OX=9606 GN=MCRIP2 PE=1 SV=2" "0.001" "False" "3.805" "7" "1" "1" "1" "160" "17.8" "9.41" "4.12" "1" "" "nucleus;other cell component" "" "Pf14799" "84331" "ENSG00000172366" "MCRIP2" "hsa:84331; Q969E9; Q96KV8; Q9BUT9" "" "" "0" "0" "1.104" "1.014" "1.141" "0.984" "0.950" "1.067" "1.040" "0.909" "1.029" "170.9" "188.6" "173.3" "194.9" "168.1" "162.3" "182.4" "177.7" "155.3" "175.8" "" "" "" "" "" "" "" "" "" "" "160.1" "156.1" "160.8" "150.7" "143.3" "155.1" "166.7" "157.7" "155.3" "169.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2663740038882364516" "False" "High" "IsMasterProtein" "Q96S82" "Ubiquitin-like protein 7 OS=Homo sapiens OX=9606 GN=UBL7 PE=1 SV=2" "0.001" "False" "3.805" "6" "2" "2" "2" "380" "40.5" "5.07" "5.51" "2" "protein metabolism;other metabolic processes;stress response" "cytosol;other cell component" "other molecular function" "Pf00240" "84993" "ENSG00000138629; ENSG00000288408" "UBL7" "D3DW57; hsa:84993; Q96I03; Q96S82" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8656179388413657305" "False" "High" "IsMasterProtein" "O00308" "NEDD4-like E3 ubiquitin-protein ligase WWP2 OS=Homo sapiens OX=9606 GN=WWP2 PE=1 SV=2" "0.001" "False" "3.804" "2" "2" "2" "1" "870" "98.9" "7.12" "4.67" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00397, Pf00632" "11060" "ENSG00000198373" "WWP2" "A6NEP1; B2R706; B4DTL5; F5H213; H3BRF3; hsa:11060; I3RSG8; O00308; Q6ZTQ5; Q96CZ2; Q9BWN6" "" "RHOQ GTPase cycle; Regulation of PTEN stability and activity; RHOJ GTPase cycle; NOTCH3 Activation and Transmission of Signal to the Nucleus; RHOU GTPase cycle" "5" "0" "1.096" "0.984" "0.996" "1.176" "1.157" "0.978" "1.212" "1.003" "1.184" "89.9" "98.5" "88.5" "89.6" "105.8" "104.1" "87.9" "109.0" "90.2" "106.5" "" "" "" "" "" "" "" "" "" "" "84.3" "81.5" "82.2" "69.3" "90.2" "99.4" "80.4" "96.8" "90.2" "102.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8029509769443933574" "False" "High" "IsMasterProtein" "Q7Z7A3" "Cytoplasmic tRNA 2-thiolation protein 1 OS=Homo sapiens OX=9606 GN=CTU1 PE=1 SV=1" "0.001" "False" "3.796" "4" "1" "1" "1" "348" "36.4" "9.20" "5.26" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf01171, Pf16503" "90353" "ENSG00000142544" "CTU1" "A8K558; hsa:90353; Q7Z7A3; Q96GZ7" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.115" "1.053" "1.051" "1.068" "1.080" "1.003" "1.025" "1.006" "1.108" "136.2" "151.8" "143.4" "143.2" "145.4" "147.1" "136.6" "139.7" "137.1" "150.9" "" "" "" "" "" "" "" "" "" "" "127.6" "125.6" "133.2" "110.7" "124.0" "140.6" "124.8" "124.0" "137.1" "145.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4925331307854051957" "False" "High" "IsMasterProtein" "Q14739" "Delta(14)-sterol reductase LBR OS=Homo sapiens OX=9606 GN=LBR PE=1 SV=2" "0.001" "False" "3.794" "3" "2" "2" "2" "615" "70.7" "9.36" "4.48" "2" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01222, Pf09465" "3930" "ENSG00000143815" "LBR" "B2R5P3; hsa:3930; Q14739; Q14740; Q53GU7; Q59FE6" "Gastric cancer network 2; Envelope proteins and their potential roles in EDMD physiopathology; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "RHOC GTPase cycle; RHOA GTPase cycle; RHOD GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Regulation of MECP2 expression and activity; Initiation of Nuclear Envelope (NE) Reformation; Cholesterol biosynthesis" "18" "0" "1.106" "1.266" "1.227" "1.184" "1.216" "1.367" "1.214" "1.241" "1.269" "43.7" "48.3" "55.3" "53.6" "51.7" "53.1" "59.7" "53.0" "54.2" "55.4" "" "" "" "" "" "" "" "" "" "" "40.9" "40.0" "51.3" "41.4" "44.0" "50.7" "54.5" "47.0" "54.2" "53.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2072306986524889695" "False" "High" "IsMasterProtein" "Q8WVD3" "E3 ubiquitin-protein ligase RNF138 OS=Homo sapiens OX=9606 GN=RNF138 PE=1 SV=1" "0.001" "False" "3.783" "7" "2" "2" "2" "245" "28.2" "6.93" "5.37" "2" "cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf05605, Pf13923, Pf18574" "51444" "ENSG00000134758" "RNF138" "B2RE17; hsa:51444; Q8WVD3; Q9H8K2; Q9UF87; Q9UKI6" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.068" "1.135" "1.086" "1.062" "1.090" "1.052" "1.079" "0.973" "1.082" "246.8" "263.5" "280.0" "268.0" "262.1" "269.0" "259.5" "266.2" "240.0" "267.1" "" "" "" "" "" "" "" "" "" "" "231.2" "218.0" "260.0" "207.2" "223.4" "257.0" "237.1" "236.4" "240.0" "257.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "729714306402912246" "False" "High" "IsMasterProtein" "Q15628" "Tumor necrosis factor receptor type 1-associated DEATH domain protein OS=Homo sapiens OX=9606 GN=TRADD PE=1 SV=2" "0.001" "False" "3.783" "3" "1" "1" "1" "312" "34.2" "6.27" "3.46" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00531, Pf09034" "8717" "ENSG00000102871" "TRADD" "B2RDS3; B3KQZ9; hsa:8717; Q15628; Q52NZ1" "TNF-alpha signaling pathway; Nanoparticle triggered regulated necrosis; Apoptosis; Ebstein-Barr virus LMP1 signaling; Novel intracellular components of RIG-I-like receptor pathway; p38 MAPK signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling; Defective RIPK1-mediated regulated necrosis" "20" "0" "0.892" "0.940" "1.068" "0.998" "0.834" "0.961" "1.023" "0.950" "0.917" "116.6" "104.0" "109.6" "124.6" "116.4" "97.3" "112.1" "119.4" "110.8" "106.9" "" "" "" "" "" "" "" "" "" "" "109.3" "86.1" "101.7" "96.3" "99.2" "93.0" "102.4" "106.0" "110.8" "103.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8117029845093264208" "False" "High" "IsMasterProtein" "O75600" "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial OS=Homo sapiens OX=9606 GN=GCAT PE=1 SV=1" "0.001" "False" "3.781" "3" "1" "1" "1" "419" "45.3" "8.05" "3.98" "1" "other metabolic processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00155" "23464" "ENSG00000100116" "GCAT" "E2QC23; hsa:23464; O75600; Q6ZWF1; Q96CA9" "" "Threonine catabolism" "1" "0" "1.028" "0.976" "1.128" "1.080" "1.030" "0.956" "0.955" "0.956" "1.038" "171.3" "176.1" "167.2" "193.2" "185.1" "176.5" "163.8" "163.6" "163.8" "177.8" "" "" "" "" "" "" "" "" "" "" "160.5" "145.7" "155.3" "149.4" "157.7" "168.6" "149.6" "145.3" "163.8" "171.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2737319948807008641" "False" "High" "IsMasterProtein" "Q9H8G2" "Caspase activity and apoptosis inhibitor 1 OS=Homo sapiens OX=9606 GN=CAAP1 PE=1 SV=2" "0.001" "False" "3.774" "4" "1" "1" "1" "361" "38.3" "4.72" "3.09" "1" "other biological processes" "" "" "Pf15335" "79886" "ENSG00000120159" "CAAP1" "B4DWT4; D3DRK4; hsa:79886; Q5VY32; Q6IPE6; Q96C59; Q9H8G2" "Acute viral myocarditis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4966290939603233061" "False" "High" "IsMasterProtein" "O00461" "Golgi integral membrane protein 4 OS=Homo sapiens OX=9606 GN=GOLIM4 PE=1 SV=1" "0.001" "False" "3.773" "2" "1" "1" "1" "696" "81.8" "4.77" "2.89" "1" "" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "" "27333" "ENSG00000173905" "GOLIM4" "hsa:27333; O00461" "" "Intra-Golgi traffic" "1" "0" "1.239" "1.273" "1.411" "1.038" "0.995" "1.357" "1.315" "1.143" "1.140" "24.7" "30.6" "31.5" "34.9" "25.7" "24.6" "33.6" "32.5" "28.3" "28.2" "" "" "" "" "" "" "" "" "" "" "23.2" "25.3" "29.2" "27.0" "21.9" "23.5" "30.7" "28.9" "28.3" "27.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1014508030414011044" "False" "High" "IsMasterProtein" "P62899" "Large ribosomal subunit protein eL31 OS=Homo sapiens OX=9606 GN=RPL31 PE=1 SV=1" "0.001" "False" "3.772" "14" "2" "4" "2" "125" "14.5" "10.54" "9.65" "2" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01198" "6160" "ENSG00000071082" "RPL31" "B7Z4K2; D3DVJ4; hsa:6160; P12947; P62899; Q53SQ5; Q6IRZ0; Q6LBJ6" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.964" "1.034" "1.096" "1.430" "1.350" "1.113" "1.132" "1.303" "1.276" "116.2" "112.0" "120.2" "127.4" "166.2" "157.0" "129.4" "131.6" "151.4" "148.3" "" "" "" "" "" "" "" "" "" "" "108.9" "92.7" "111.6" "98.5" "141.7" "150.0" "118.2" "116.8" "151.4" "142.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6623340480838481175" "False" "High" "IsMasterProtein" "Q15287" "RNA-binding protein with serine-rich domain 1 OS=Homo sapiens OX=9606 GN=RNPS1 PE=1 SV=1" "0.001" "False" "3.764" "5" "1" "1" "1" "305" "34.2" "11.84" "3.69" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "10921" "ENSG00000205937" "RNPS1" "A8K1P0; B4DDU8; B4DZU7; B7ZA17; hsa:10921; O75308; Q15287; Q32P25; Q8WY42; Q9NYG3" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "7" "0" "1.162" "1.172" "1.070" "1.180" "1.065" "1.058" "0.963" "1.084" "1.144" "158.0" "183.6" "185.2" "169.1" "186.4" "168.2" "167.1" "152.1" "171.2" "180.8" "" "" "" "" "" "" "" "" "" "" "148.0" "151.9" "171.9" "130.7" "158.9" "160.7" "152.7" "135.0" "171.2" "174.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4235790517375748562" "False" "High" "IsMasterProtein" "O43924" "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta OS=Homo sapiens OX=9606 GN=PDE6D PE=1 SV=1" "0.001" "False" "3.763" "8" "1" "1" "1" "150" "17.4" "5.67" "4.12" "1" "other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf05351" "5147" "ENSG00000156973" "PDE6D" "hsa:5147; O43250; O43924" "Phosphodiesterases in neuronal function; Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "ARL13B-mediated ciliary trafficking of INPP5E; RAS processing" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "370304273166594920" "False" "High" "IsMasterProtein" "O94906" "Pre-mRNA-processing factor 6 OS=Homo sapiens OX=9606 GN=PRPF6 PE=1 SV=1" "0.001" "False" "3.760" "1" "2" "2" "2" "941" "106.9" "8.25" "5.24" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06424, Pf13181, Pf14559" "24148" "ENSG00000101161" "PRPF6" "B2RAR5; B3KMC6; hsa:24148; O94906; O95109; Q5VXS5; Q9H3Z1; Q9H4T9; Q9H4U8; Q9NTE6" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "1.213" "0.900" "1.275" "1.066" "0.825" "1.104" "0.966" "0.925" "0.919" "348.2" "422.4" "313.3" "443.8" "371.2" "287.3" "384.6" "336.3" "322.1" "320.0" "" "" "" "" "" "" "" "" "" "" "326.3" "349.5" "290.9" "343.1" "316.4" "274.5" "351.4" "298.6" "322.1" "308.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8998736333335138172" "False" "High" "IsMasterProtein" "Q08623" "Pseudouridine-5'-phosphatase OS=Homo sapiens OX=9606 GN=PUDP PE=1 SV=3" "0.001" "False" "3.757" "4" "1" "1" "1" "228" "25.2" "5.31" "4.01" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf13419" "8226" "ENSG00000130021" "PUDP" "B2R7X6; B4DV93; B7Z6Q3; E9PAV8; F5GWZ2; hsa:8226; Q08623; Q53F84; Q96EB8" "" "Pyrimidine salvage" "1" "0" "0.873" "1.012" "1.011" "1.105" "1.054" "0.907" "1.005" "0.992" "1.051" "221.1" "193.1" "223.8" "223.5" "244.3" "233.1" "200.6" "222.3" "219.4" "232.4" "" "" "" "" "" "" "" "" "" "" "207.2" "159.8" "207.7" "172.8" "208.2" "222.7" "183.3" "197.4" "219.4" "223.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5841636671217917151" "False" "High" "IsMasterProtein" "Q5JTJ3" "Cytochrome c oxidase assembly factor 6 homolog OS=Homo sapiens OX=9606 GN=COA6 PE=1 SV=1" "0.001" "False" "3.744" "11" "1" "1" "1" "125" "14.1" "8.25" "3.73" "1" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;mitochondrion;nucleus" "other molecular function" "Pf02297" "388753" "ENSG00000168275" "COA6" "hsa:388753; Q5JTJ2; Q5JTJ3; Q5JTJ4; Q8TA88" "Mitochondrial complex IV assembly" "Mitochondrial protein import" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4219783111601557579" "False" "High" "IsMasterProtein" "Q13216" "DNA excision repair protein ERCC-8 OS=Homo sapiens OX=9606 GN=ERCC8 PE=1 SV=1" "0.001" "False" "3.744" "4" "2" "2" "2" "396" "44.0" "6.35" "3.07" "2" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400" "1161" "ENSG00000049167" "ERCC8" "B2RB64; hsa:1161; Q13216; Q6FHX5; Q96GB9" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 10q11.21q11.23 copy number variation syndrome" "Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "9" "0" "1.054" "1.044" "1.012" "0.983" "1.057" "1.129" "1.054" "1.134" "1.003" "246.7" "260.0" "257.4" "249.7" "242.4" "260.7" "278.5" "260.0" "279.8" "247.3" "" "" "" "" "" "" "" "" "" "" "231.1" "215.2" "239.0" "193.0" "206.7" "249.1" "254.4" "230.9" "279.8" "238.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2507883408374064742" "False" "High" "IsMasterProtein" "O14874" "Branched-chain alpha-ketoacid dehydrogenase kinase OS=Homo sapiens OX=9606 GN=BCKDK PE=1 SV=2" "0.001" "False" "3.740" "3" "1" "1" "1" "412" "46.3" "8.82" "3.34" "1" "other metabolic processes;other biological processes" "mitochondrion" "kinase activity;other molecular function" "Pf02518, Pf10436" "10295" "ENSG00000103507" "BCKDK" "A8MY43; hsa:10295; O14874; Q6FGL4; Q96G95; Q96IN5" "Thiamine metabolic pathways" "Branched-chain amino acid catabolism" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4817136226994286796" "False" "High" "IsMasterProtein" "Q149N8" "E3 ubiquitin-protein ligase SHPRH OS=Homo sapiens OX=9606 GN=SHPRH PE=1 SV=2" "0.001" "False" "3.738" "1" "2" "2" "2" "1683" "193.0" "7.47" "1.82" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00538, Pf13445, Pf21324, Pf21325" "257218" "ENSG00000146414" "SHPRH" "hsa:257218; Q149N8; Q149N9; Q5VV79; Q68DS5; Q7Z5J5; Q8IVE8; Q8IWQ9; Q8N1S8; Q8NBR7" "" "E3 ubiquitin ligases ubiquitinate target proteins" "1" "0" "1.162" "0.959" "1.423" "1.177" "1.104" "1.091" "1.030" "1.124" "1.033" "136.8" "159.0" "131.3" "194.7" "161.0" "151.1" "149.3" "140.9" "153.8" "141.4" "" "" "" "" "" "" "" "" "" "" "128.2" "131.6" "121.9" "150.5" "137.2" "144.3" "136.4" "125.1" "153.8" "136.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8343966935655594345" "False" "High" "IsMasterProtein" "P56385" "ATP synthase subunit e, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5ME PE=1 SV=2" "0.001" "False" "3.737" "14" "1" "1" "1" "69" "7.9" "9.35" "3.83" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05680" "521" "ENSG00000169020" "ATP5ME" "hsa:521; P56385; Q0D2L9" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "Cristae formation; Formation of ATP by chemiosmotic coupling" "4" "0" "1.134" "1.059" "1.075" "1.257" "1.035" "1.070" "1.067" "1.083" "1.132" "146.1" "165.6" "154.7" "157.1" "183.6" "151.1" "156.3" "155.8" "158.2" "165.3" "" "" "" "" "" "" "" "" "" "" "136.9" "137.0" "143.7" "121.4" "156.5" "144.4" "142.8" "138.4" "158.2" "159.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "138932936592921501" "False" "High" "IsMasterProtein" "Q9ULJ3" "Zinc finger and BTB domain-containing protein 21 OS=Homo sapiens OX=9606 GN=ZBTB21 PE=1 SV=2" "0.001" "False" "3.737" "1" "1" "1" "1" "1066" "118.8" "8.29" "3.80" "1" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651, Pf18450" "49854" "ENSG00000173276" "ZBTB21" "hsa:49854; Q5R2W1; Q5R2W2; Q6P4R0; Q9ULJ3" "" "" "0" "0" "1.126" "1.041" "1.062" "1.204" "1.068" "1.148" "1.169" "1.043" "1.136" "136.7" "153.8" "142.2" "145.1" "164.5" "145.9" "156.9" "159.7" "142.5" "155.3" "" "" "" "" "" "" "" "" "" "" "128.0" "127.3" "132.0" "112.1" "140.2" "139.4" "143.3" "141.8" "142.5" "149.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6585910940532122349" "False" "High" "IsMasterProtein" "Q5U5X0" "Complex III assembly factor LYRM7 OS=Homo sapiens OX=9606 GN=LYRM7 PE=1 SV=1" "0.001" "False" "3.725" "10" "1" "2" "1" "104" "11.9" "9.66" "6.72" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf05347" "90624" "ENSG00000186687" "LYRM7" "A8MPQ9; hsa:90624; Q5U5X0; Q86Y68" "Mitochondrial complex III assembly" "" "1" "0" "1.156" "0.997" "1.223" "1.053" "1.005" "1.160" "0.876" "0.867" "1.115" "98.9" "114.3" "98.6" "121.0" "104.2" "99.4" "114.7" "86.7" "85.7" "110.2" "" "" "" "" "" "" "" "" "" "" "92.7" "94.6" "91.5" "93.5" "88.8" "94.9" "104.8" "76.9" "85.7" "106.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6981567354116466271" "False" "High" "IsMasterProtein" "O43542" "DNA repair protein XRCC3 OS=Homo sapiens OX=9606 GN=XRCC3 PE=1 SV=1" "0.001" "False" "3.723" "3" "1" "1" "1" "346" "37.8" "8.48" "3.27" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "7517" "ENSG00000126215" "XRCC3" "hsa:7517; O43542; O43568; Q9BU18" "Fluoropyrimidine activity; Male infertility" "Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2687201697740038391" "False" "High" "IsMasterProtein" "Q9NP92" "Large ribosomal subunit protein mL65 OS=Homo sapiens OX=9606 GN=MRPS30 PE=1 SV=2" "0.001" "False" "3.721" "5" "2" "2" "2" "439" "50.3" "7.97" "5.28" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf07147" "10884" "ENSG00000112996" "MRPS30" "hsa:10884; Q96I91; Q96Q19; Q9H0P8; Q9NP92; Q9NSF9; Q9NZ76" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.959" "1.047" "0.984" "1.017" "1.010" "0.968" "1.018" "1.016" "1.028" "249.4" "239.2" "261.1" "245.5" "253.7" "251.8" "241.5" "253.9" "253.3" "256.5" "" "" "" "" "" "" "" "" "" "" "233.7" "197.9" "242.4" "189.8" "216.3" "240.6" "220.6" "225.5" "253.3" "246.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1233062915994962718" "False" "High" "IsMasterProtein" "Q9HC16" "DNA dC->dU-editing enzyme APOBEC-3G OS=Homo sapiens OX=9606 GN=APOBEC3G PE=1 SV=1" "0.001" "False" "3.718" "4" "2" "2" "2" "384" "46.4" "8.00" "4.86" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05240, Pf18782" "60489" "ENSG00000239713" "APOBEC3G" "B2RDR9; hsa:60489; Q45F02; Q5TF77; Q7Z2N1; Q7Z2N4; Q9H9H8; Q9HC16" "Dual hijack model of Vif in HIV infection" "" "1" "0" "1.056" "1.047" "1.243" "1.083" "1.121" "0.975" "1.105" "1.011" "1.101" "338.6" "357.5" "354.5" "420.9" "366.7" "379.6" "330.0" "374.0" "342.3" "372.7" "" "" "" "" "" "" "" "" "" "" "317.3" "295.8" "329.1" "325.4" "312.6" "362.7" "301.5" "332.1" "342.3" "358.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1674970657433919693" "False" "High" "IsMasterProtein" "P51159" "Ras-related protein Rab-27A OS=Homo sapiens OX=9606 GN=RAB27A PE=1 SV=3" "0.001" "False" "3.717" "5" "1" "1" "1" "221" "24.9" "5.22" "3.22" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "5873" "ENSG00000069974" "RAB27A" "hsa:5873; O00195; P51159; Q6FI40; Q9UIR9; Q9Y5U3" "Deregulation of Rab and Rab effector genes in bladder cancer; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; 2q37 copy number variation syndrome" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Insulin processing" "7" "0" "1.015" "0.953" "1.067" "1.042" "1.009" "0.934" "0.963" "0.992" "0.979" "111.0" "112.7" "105.8" "118.4" "115.7" "112.0" "103.7" "106.9" "110.1" "108.7" "" "" "" "" "" "" "" "" "" "" "104.0" "93.3" "98.3" "91.6" "98.6" "107.0" "94.7" "94.9" "110.1" "104.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8095866348413873216" "False" "High" "IsMasterProtein" "Q8WUB8" "PHD finger protein 10 OS=Homo sapiens OX=9606 GN=PHF10 PE=1 SV=3" "0.001" "False" "3.710" "2" "1" "1" "1" "498" "56.0" "6.62" "3.80" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00628" "55274" "ENSG00000130024" "PHF10" "hsa:55274; Q2YDA3; Q53HG8; Q8WUB8; Q9BXD2; Q9NV26" "" "" "0" "0" "0.874" "0.884" "0.860" "0.977" "0.977" "0.865" "0.891" "0.870" "0.919" "145.6" "127.3" "128.7" "125.2" "142.3" "142.2" "125.9" "129.7" "126.7" "133.8" "" "" "" "" "" "" "" "" "" "" "136.4" "105.3" "119.5" "96.8" "121.3" "135.9" "115.1" "115.2" "126.7" "128.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7705626466042458302" "False" "High" "IsMasterProtein" "O75191" "Xylulose kinase OS=Homo sapiens OX=9606 GN=XYLB PE=1 SV=3" "0.001" "False" "3.709" "3" "1" "1" "1" "536" "58.3" "5.86" "3.71" "1" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf00370, Pf02782" "9942" "ENSG00000093217" "XYLB" "B2RAW4; B4DDT2; B9EH64; hsa:9942; O75191" "" "Formation of xylulose-5-phosphate" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "127392206666109507" "False" "High" "IsMasterProtein" "O95166" "Gamma-aminobutyric acid receptor-associated protein OS=Homo sapiens OX=9606 GN=GABARAP PE=1 SV=1" "0.001" "False" "3.706" "12" "2" "5" "1" "117" "13.9" "8.79" "9.78" "2" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02991" "11337" "ENSG00000170296" "GABARAP" "hsa:11337; O95166" "2q37 copy number variation syndrome; 8q11.23 (RB1CC1) copy number variation" "Macroautophagy; TBC/RABGAPs" "4" "0" "0.919" "0.908" "0.900" "0.969" "0.948" "0.880" "0.970" "0.917" "0.932" "248.4" "228.2" "225.5" "223.6" "240.7" "235.5" "218.4" "241.0" "227.7" "231.4" "" "" "" "" "" "" "" "" "" "" "232.7" "188.8" "209.4" "172.9" "205.1" "225.0" "199.6" "214.0" "227.7" "222.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-90342498941342912" "False" "High" "IsMasterProtein" "Q8N8R5" "Mitochondrial protein C2orf69 OS=Homo sapiens OX=9606 GN=C2orf69 PE=1 SV=1" "0.001" "False" "3.699" "3" "1" "1" "1" "385" "43.4" "8.09" "3.77" "1" "other metabolic processes" "other membranes;mitochondrion" "" "Pf10561" "205327" "ENSG00000178074" "C2orf69" "hsa:205327; Q8N8R5; Q8NE30" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8660233523405071508" "False" "High" "IsMasterProtein" "A0FGR8" "Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1" "0.001" "False" "3.699" "1" "1" "1" "1" "921" "102.3" "9.26" "3.97" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00168, Pf17047" "57488" "ENSG00000117868" "ESYT2" "A0FGR8; A4D229; hsa:57488; Q69YJ2; Q6UKI4; Q6ZTU0; Q6ZVU1; Q9BQS0; Q9NW47; Q9ULJ2" "" "Glycosphingolipid transport" "1" "0" "1.084" "1.059" "1.103" "1.018" "0.975" "0.915" "0.908" "0.913" "0.956" "133.3" "144.5" "141.2" "147.0" "135.7" "129.9" "121.9" "120.9" "121.7" "127.4" "" "" "" "" "" "" "" "" "" "" "124.9" "119.5" "131.1" "113.6" "115.7" "124.1" "111.4" "107.4" "121.7" "122.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6957065747657519198" "False" "High" "IsMasterProtein" "P33552" "Cyclin-dependent kinases regulatory subunit 2 OS=Homo sapiens OX=9606 GN=CKS2 PE=1 SV=1" "0.001" "False" "3.699" "20" "2" "2" "1" "79" "9.9" "8.46" "3.13" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf01111" "1164" "ENSG00000123975" "CKS2" "hsa:1164; P33552; Q6FGI9; Q6LET5" "Small cell lung cancer" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6079513439335487390" "False" "High" "IsMasterProtein" "Q9UGV2" "Protein NDRG3 OS=Homo sapiens OX=9606 GN=NDRG3 PE=1 SV=2" "0.001" "False" "3.696" "4" "1" "3" "1" "375" "41.4" "5.31" "9.18" "1" "signal transduction;other biological processes" "other cell component" "" "Pf03096" "57446" "ENSG00000101079" "NDRG3" "A2A2S8; E1P5U7; E1P5U8; hsa:57446; Q5TH32; Q96PL8; Q96SM2; Q9BXY7; Q9H3N7; Q9H411; Q9H8J6; Q9UGV2" "" "" "0" "0" "0.958" "1.009" "0.997" "1.077" "1.124" "0.972" "0.977" "1.092" "1.149" "150.5" "144.2" "151.9" "150.1" "162.1" "169.2" "146.2" "147.0" "164.3" "172.9" "" "" "" "" "" "" "" "" "" "" "141.0" "119.3" "141.0" "116.0" "138.1" "161.6" "133.6" "130.5" "164.3" "166.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6687870354662644574" "False" "High" "IsMasterProtein" "Q8N3D4" "EH domain-binding protein 1-like protein 1 OS=Homo sapiens OX=9606 GN=EHBP1L1 PE=1 SV=2" "0.001" "False" "3.692" "1" "1" "1" "1" "1523" "161.8" "4.83" "2.62" "1" "" "other cytoplasmic organelle" "" "Pf00307, Pf10358, Pf12130" "254102" "ENSG00000173442" "EHBP1L1" "hsa:254102; Q8N3D4; Q8TB89; Q9H7M7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3859888159614048527" "False" "High" "IsMasterProtein" "Q9NRP4" "Succinate dehydrogenase assembly factor 3, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF3 PE=1 SV=1" "0.001" "False" "3.691" "7" "1" "1" "1" "125" "14.6" "9.07" "3.62" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "mitochondrion" "" "Pf13233" "57001" "ENSG00000196636" "SDHAF3" "A4D1J3; hsa:57001; Q75MD6; Q9NRP4" "Mitochondrial complex II assembly" "" "1" "0" "1.079" "1.078" "0.976" "1.197" "0.994" "1.121" "1.016" "0.998" "1.078" "100.2" "108.1" "108.0" "97.8" "119.9" "99.6" "112.3" "101.7" "100.0" "107.9" "" "" "" "" "" "" "" "" "" "" "93.9" "89.5" "100.3" "75.6" "102.2" "95.1" "102.6" "90.3" "100.0" "103.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1704471211926066966" "False" "High" "IsMasterProtein" "Q8TEM1" "Nuclear pore membrane glycoprotein 210 OS=Homo sapiens OX=9606 GN=NUP210 PE=1 SV=3" "0.002" "False" "3.685" "1" "1" "1" "1" "1887" "205.0" "6.81" "3.40" "1" "transport" "other membranes;ER/Golgi;nucleus" "" "Pf02368" "23225" "ENSG00000132182" "NUP210" "A6NN56; hsa:23225; O94980; Q6NXG6; Q8NBJ1; Q8TEM1; Q9H6C8; Q9UFP3" "" "Nuclear Pore Complex (NPC) Disassembly; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; snRNP Assembly; Regulation of HSF1-mediated heat shock response; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; HCMV Late Events; SUMOylation of RNA binding proteins; HCMV Early Events; Transcriptional regulation by small RNAs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "28" "0" "1.087" "1.006" "1.214" "1.123" "1.030" "1.020" "1.040" "1.102" "0.924" "134.2" "145.9" "134.9" "163.0" "150.7" "138.3" "136.8" "139.6" "147.8" "124.0" "" "" "" "" "" "" "" "" "" "" "125.7" "120.7" "125.3" "126.0" "128.4" "132.1" "125.0" "123.9" "147.8" "119.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6825792350743248999" "False" "High" "IsMasterProtein" "P07738" "Bisphosphoglycerate mutase OS=Homo sapiens OX=9606 GN=BPGM PE=1 SV=2" "0.002" "False" "3.681" "5" "1" "1" "1" "259" "30.0" "6.54" "2.91" "1" "other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00300" "669" "ENSG00000172331" "BPGM" "A4D1N9; hsa:669; P07738" "IL-18 signaling pathway" "Glycolysis" "2" "0" "1.122" "1.172" "1.246" "1.189" "1.062" "1.152" "1.241" "1.092" "1.227" "40.5" "45.4" "47.5" "50.5" "48.1" "43.0" "46.6" "50.2" "44.2" "49.7" "" "" "" "" "" "" "" "" "" "" "37.9" "37.6" "44.1" "39.0" "41.0" "41.1" "42.6" "44.6" "44.2" "47.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3451849306749892991" "False" "High" "IsMasterProtein" "P49459" "Ubiquitin-conjugating enzyme E2 A OS=Homo sapiens OX=9606 GN=UBE2A PE=1 SV=2" "0.002" "False" "3.679" "7" "1" "1" "1" "152" "17.3" "5.15" "4.08" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7319" "ENSG00000077721" "UBE2A" "A6NFE9; A6NGR2; A6NMF5; B2R7R9; D3DWI1; hsa:7319; P49459; Q4TTG1; Q96FX4" "" "E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "3" "0" "1.079" "1.072" "1.162" "1.068" "1.146" "1.090" "1.170" "1.099" "1.079" "176.7" "190.7" "189.4" "205.4" "188.6" "202.5" "192.6" "206.6" "194.2" "190.6" "" "" "" "" "" "" "" "" "" "" "165.6" "157.8" "175.8" "158.8" "160.8" "193.5" "176.0" "183.5" "194.2" "183.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4269157593658569788" "False" "High" "IsMasterProtein" "Q9NXV2" "BTB/POZ domain-containing protein KCTD5 OS=Homo sapiens OX=9606 GN=KCTD5 PE=1 SV=1" "0.002" "False" "3.675" "6" "1" "1" "1" "234" "26.1" "6.24" "3.22" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02214" "54442" "ENSG00000167977" "KCTD5" "D3DU96; hsa:54442; Q9NXV2" "" "" "0" "0" "1.087" "0.832" "1.119" "0.871" "0.828" "1.050" "0.868" "0.876" "0.883" "317.9" "345.5" "264.5" "355.8" "276.8" "263.3" "333.8" "275.8" "278.5" "280.6" "" "" "" "" "" "" "" "" "" "" "297.8" "285.9" "245.6" "275.0" "236.0" "251.6" "305.0" "244.9" "278.5" "270.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2540636687362609874" "False" "High" "IsMasterProtein" "O94768" "Serine/threonine-protein kinase 17B OS=Homo sapiens OX=9606 GN=STK17B PE=1 SV=1" "0.002" "False" "3.672" "2" "1" "1" "1" "372" "42.3" "5.25" "3.88" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "9262" "ENSG00000081320" "STK17B" "hsa:9262; O94768" "" "" "0" "0" "1.019" "1.103" "0.922" "1.084" "1.020" "0.869" "0.977" "1.088" "1.028" "288.3" "293.8" "318.1" "265.7" "312.4" "293.9" "250.6" "281.5" "313.6" "296.4" "" "" "" "" "" "" "" "" "" "" "270.1" "243.1" "295.3" "205.4" "266.3" "280.8" "229.0" "250.0" "313.6" "285.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6640745081908687038" "False" "High" "IsMasterProtein" "O75521" "Enoyl-CoA delta isomerase 2 OS=Homo sapiens OX=9606 GN=ECI2 PE=1 SV=4" "0.002" "False" "3.670" "4" "2" "2" "2" "394" "43.6" "9.00" "5.16" "2" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00378, Pf00887" "10455" "ENSG00000198721" "ECI2" "hsa:10455; O75521; Q5JYK5; Q5JYK7; Q7L124; Q8N0X0; Q9BUE9; Q9H0T9; Q9NQH1; Q9NYH7; Q9UN55" "" "" "0" "0" "1.050" "0.976" "0.955" "1.012" "1.114" "1.008" "1.027" "1.024" "1.144" "256.1" "268.8" "249.9" "244.5" "259.2" "285.3" "258.2" "263.0" "262.2" "293.1" "" "" "" "" "" "" "" "" "" "" "239.9" "222.4" "232.0" "189.0" "221.0" "272.6" "235.9" "233.5" "262.2" "282.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6670278986062403757" "False" "High" "IsMasterProtein" "P17050" "Alpha-N-acetylgalactosaminidase OS=Homo sapiens OX=9606 GN=NAGA PE=1 SV=2" "0.002" "False" "3.668" "3" "1" "1" "1" "411" "46.5" "5.19" "3.94" "1" "other metabolic processes" "other cytoplasmic organelle;other cell component" "other molecular function" "Pf16499, Pf17450" "4668" "ENSG00000198951" "NAGA" "hsa:4668; P17050" "" "" "0" "0" "0.990" "1.017" "1.066" "1.064" "1.056" "1.006" "1.017" "1.072" "1.020" "223.7" "221.4" "227.6" "238.4" "238.0" "236.1" "225.0" "227.5" "239.8" "228.2" "" "" "" "" "" "" "" "" "" "" "209.6" "183.2" "211.3" "184.3" "202.9" "225.6" "205.6" "202.0" "239.8" "219.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4411072855446400187" "False" "High" "IsMasterProtein" "Q9UHA2" "SS18-like protein 2 OS=Homo sapiens OX=9606 GN=SS18L2 PE=1 SV=1" "0.002" "False" "3.667" "13" "1" "1" "1" "77" "8.8" "5.83" "3.59" "1" "other biological processes" "" "other molecular function" "Pf05030" "51188" "ENSG00000008324" "SS18L2" "B2R5L1; hsa:51188; Q9UHA2" "" "" "0" "0" "1.021" "0.868" "0.931" "1.023" "0.814" "0.920" "0.808" "0.836" "0.910" "154.0" "157.3" "133.7" "143.3" "157.5" "125.3" "141.7" "124.4" "128.7" "140.1" "" "" "" "" "" "" "" "" "" "" "144.3" "130.1" "124.2" "110.8" "134.2" "119.8" "129.5" "110.4" "128.7" "134.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9158242191706838173" "False" "High" "IsMasterProtein" "Q71RC2" "La-related protein 4 OS=Homo sapiens OX=9606 GN=LARP4 PE=1 SV=3" "0.002" "False" "3.667" "2" "1" "1" "1" "724" "80.5" "6.61" "4.06" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf05383" "113251" "ENSG00000161813" "LARP4" "A8K6T1; E9PDG5; G3XAA8; G5E976; hsa:113251; Q5CZ97; Q6ZV14; Q71RC2; Q96NF9" "" "" "0" "0" "1.098" "1.097" "1.271" "1.255" "1.248" "1.339" "1.170" "1.295" "1.181" "163.8" "179.8" "179.6" "208.1" "205.5" "204.3" "219.3" "191.5" "212.0" "193.5" "" "" "" "" "" "" "" "" "" "" "153.4" "148.8" "166.8" "160.9" "175.2" "195.2" "200.4" "170.1" "212.0" "186.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-332338773626550486" "False" "High" "IsMasterProtein" "Q9BQI3" "Eukaryotic translation initiation factor 2-alpha kinase 1 OS=Homo sapiens OX=9606 GN=EIF2AK1 PE=1 SV=2" "0.002" "False" "3.663" "2" "1" "1" "1" "630" "71.1" "5.99" "3.72" "1" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "27102" "ENSG00000086232" "EIF2AK1" "A8K2R2; hsa:27102; Q549K6; Q8NBW3; Q9BQI3; Q9HC02; Q9NYE0; Q9P0V6; Q9P1J5; Q9P2H8; Q9UHG4" "Translation factors; Measles virus infection" "Response of EIF2AK1 (HRI) to heme deficiency; Cellular response to mitochondrial stress" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-143757823348630571" "False" "High" "IsMasterProtein" "Q8IV08" "5'-3' exonuclease PLD3 OS=Homo sapiens OX=9606 GN=PLD3 PE=1 SV=1" "0.002" "False" "3.652" "2" "1" "1" "1" "490" "54.7" "6.47" "3.55" "1" "DNA metabolism;stress response;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf13918" "23646" "ENSG00000105223" "PLD3" "hsa:23646; Q8IV08; Q92853; Q9BW87" "" "Role of phospholipids in phagocytosis; Synthesis of PG" "2" "0" "0.905" "0.929" "1.072" "0.992" "0.940" "1.040" "0.933" "0.928" "0.942" "171.6" "155.3" "159.4" "183.9" "170.2" "161.4" "178.5" "160.1" "159.3" "161.7" "" "" "" "" "" "" "" "" "" "" "160.8" "128.5" "148.0" "142.2" "145.1" "154.2" "163.1" "142.1" "159.3" "155.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1155650016836113983" "False" "High" "IsMasterProtein" "Q6NYC1" "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 OS=Homo sapiens OX=9606 GN=JMJD6 PE=1 SV=1" "0.002" "False" "3.651" "4" "1" "1" "1" "403" "46.4" "8.69" "2.99" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "23210" "ENSG00000070495" "JMJD6" "B3KMN8; B4DGX1; hsa:23210; Q6NYC1; Q86VY0; Q8IUM5; Q9Y4E2" "" "Protein hydroxylation; HDMs demethylate histones" "2" "0" "0.939" "1.160" "1.168" "1.022" "1.231" "1.156" "1.167" "1.115" "1.132" "72.6" "68.1" "84.2" "84.8" "74.2" "89.4" "83.9" "84.7" "80.9" "82.2" "" "" "" "" "" "" "" "" "" "" "68.0" "56.4" "78.1" "65.6" "63.2" "85.4" "76.6" "75.2" "80.9" "79.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7666744292030772641" "False" "High" "IsMasterProtein" "Q9BRK5" "45 kDa calcium-binding protein OS=Homo sapiens OX=9606 GN=SDF4 PE=1 SV=1" "0.002" "False" "3.651" "4" "1" "1" "1" "362" "41.8" "4.86" "4.44" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13202, Pf13499" "51150" "" "SDF4" "B1AME5; B1AME6; B2RDF1; B4DSM1; hsa:51150; Q53G52; Q53HQ9; Q8NBQ3; Q96AA1; Q9BRK5; Q9NZP7; Q9UN53" "" "" "0" "0" "1.165" "1.061" "1.066" "1.165" "1.303" "1.195" "1.109" "1.076" "1.236" "74.2" "86.4" "78.7" "79.1" "86.4" "96.6" "88.7" "82.2" "79.8" "91.7" "" "" "" "" "" "" "" "" "" "" "69.5" "71.5" "73.1" "61.1" "73.6" "92.3" "81.0" "73.0" "79.8" "88.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8486015732534254879" "False" "High" "IsMasterProtein" "Q7Z5W3" "RNA 5'-monophosphate methyltransferase OS=Homo sapiens OX=9606 GN=BCDIN3D PE=1 SV=1" "0.002" "False" "3.648" "3" "1" "1" "1" "292" "33.2" "6.70" "3.86" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06859" "144233" "ENSG00000186666" "BCDIN3D" "A8K829; hsa:144233; Q7Z5W3" "" "MicroRNA (miRNA) biogenesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5948729275611586048" "False" "High" "IsMasterProtein" "Q70IA6" "MOB kinase activator 2 OS=Homo sapiens OX=9606 GN=MOB2 PE=1 SV=1" "0.002" "False" "3.646" "7" "2" "2" "2" "237" "26.9" "6.79" "2.94" "2" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03637" "81532" "ENSG00000182208; ENSG00000291442" "MOB2" "B4DKP3; hsa:81532; Q70IA6; Q96M67" "" "" "0" "0" "1.027" "1.047" "1.117" "1.250" "0.984" "1.264" "0.982" "0.987" "1.044" "189.6" "194.7" "198.5" "211.9" "237.1" "186.6" "239.7" "186.2" "187.2" "197.9" "" "" "" "" "" "" "" "" "" "" "177.7" "161.1" "184.3" "163.8" "202.1" "178.3" "219.0" "165.4" "187.2" "190.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2890677899884632439" "False" "High" "IsMasterProtein" "Q01201" "Transcription factor RelB OS=Homo sapiens OX=9606 GN=RELB PE=1 SV=2" "0.002" "False" "3.645" "4" "2" "2" "2" "579" "62.1" "6.24" "4.66" "2" "stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179, Pf16180, Pf16181" "5971" "ENSG00000104856" "RELB" "hsa:5971; Q01201; Q6GTX7; Q9UEI7" "RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; EDA signaling in hair follicle development; Ebola virus infection in host; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Osteoarthritic chondrocyte hypertrophy" "Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; CD209 (DC-SIGN) signaling" "14" "0" "1.115" "0.969" "1.082" "0.857" "0.834" "1.181" "1.167" "0.930" "0.975" "159.9" "178.3" "155.0" "173.0" "137.0" "133.4" "188.9" "186.6" "148.7" "155.8" "" "" "" "" "" "" "" "" "" "" "149.8" "147.5" "143.9" "133.8" "116.8" "127.4" "172.6" "165.7" "148.7" "150.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-268059577032989138" "False" "High" "IsMasterProtein" "Q9NVJ2" "ADP-ribosylation factor-like protein 8B OS=Homo sapiens OX=9606 GN=ARL8B PE=1 SV=1" "0.002" "False" "3.639" "5" "1" "1" "1" "186" "21.5" "8.43" "4.09" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00025" "55207" "ENSG00000134108" "ARL8B" "B4DI85; hsa:55207; Q9NVJ2" "Ciliary landscape" "" "1" "0" "1.099" "0.870" "0.994" "0.920" "1.160" "0.814" "0.965" "1.048" "0.995" "258.3" "284.0" "224.7" "256.8" "237.6" "299.6" "210.2" "249.2" "270.8" "256.9" "" "" "" "" "" "" "" "" "" "" "242.0" "235.0" "208.6" "198.5" "202.6" "286.3" "192.1" "221.3" "270.8" "247.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4527402495997135849" "False" "High" "IsMasterProtein" "Q08AG7" "Mitotic-spindle organizing protein 1 OS=Homo sapiens OX=9606 GN=MZT1 PE=1 SV=2" "0.002" "False" "3.639" "13" "1" "1" "1" "82" "8.5" "4.78" "2.81" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf12554" "440145" "ENSG00000204899" "MZT1" "hsa:440145; Q08AG7; Q5W0P5" "" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "2" "0" "1.035" "0.854" "0.994" "0.942" "0.989" "0.991" "0.889" "0.801" "0.936" "167.1" "173.1" "142.7" "166.2" "157.4" "165.3" "165.7" "148.5" "133.9" "156.4" "" "" "" "" "" "" "" "" "" "" "156.6" "143.2" "132.5" "128.4" "134.2" "158.0" "151.4" "131.9" "133.9" "150.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4517606527837170781" "False" "High" "IsMasterProtein" "Q9Y5P6" "Mannose-1-phosphate guanyltransferase beta OS=Homo sapiens OX=9606 GN=GMPPB PE=1 SV=2" "0.002" "False" "3.638" "3" "1" "2" "1" "360" "39.8" "6.61" "6.07" "1" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00132, Pf00483" "29925" "ENSG00000173540" "GMPPB" "A8K6N5; hsa:29925; Q9H7U3; Q9Y5P6" "N-glycan biosynthesis" "Synthesis of GDP-mannose" "2" "0" "0.994" "0.995" "1.042" "1.004" "1.012" "0.988" "1.044" "1.037" "0.953" "546.2" "543.1" "543.7" "569.4" "548.1" "552.5" "539.7" "570.1" "566.7" "520.8" "" "" "" "" "" "" "" "" "" "" "511.8" "449.4" "504.8" "440.1" "467.2" "527.8" "493.2" "506.2" "566.7" "501.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3159074218320120217" "False" "High" "IsMasterProtein" "A8MT69" "Centromere protein X OS=Homo sapiens OX=9606 GN=CENPX PE=1 SV=1" "0.002" "False" "3.637" "11" "1" "1" "1" "81" "9.0" "5.90" "3.68" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09415" "201254" "ENSG00000169689" "CENPX" "A8MT69; hsa:201254; O00281; O00282; Q96DD4; Q96F51" "DNA repair pathways, full network" "Fanconi Anemia Pathway; PKR-mediated signaling; Deposition of new CENPA-containing nucleosomes at the centromere" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8110732802669380645" "False" "High" "IsMasterProtein" "P24864" "G1/S-specific cyclin-E1 OS=Homo sapiens OX=9606 GN=CCNE1 PE=1 SV=2" "0.002" "False" "3.635" "3" "1" "1" "1" "410" "47.0" "6.04" "3.48" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00134, Pf02984" "898" "ENSG00000105173" "CCNE1" "A8K684; hsa:898; P24864; Q14091; Q8NFG1; Q92501; Q9UD21" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; Retinoblastoma gene in cancer; ATM signaling pathway; Vitamin D receptor pathway; Photodynamic therapy-induced AP-1 survival signaling; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; p53 transcriptional gene network; Pleural mesothelioma; GDNF signaling; Urotensin-II-mediated signaling pathway; ID signaling pathway; TROP2 regulatory signaling; NF1 copy number variation syndrome ; DNA damage response" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Association of TriC/CCT with target proteins during biosynthesis; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); RHOBTB3 ATPase cycle; DNA Damage/Telomere Stress Induced Senescence; G1/S-Specific Transcription; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response; PTK6 Regulates Cell Cycle" "38" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8080322362920288108" "False" "High" "IsMasterProtein" "Q7Z7F0" "KH homology domain-containing protein 4 OS=Homo sapiens OX=9606 GN=KHDC4 PE=1 SV=1" "0.002" "False" "3.632" "1" "1" "1" "1" "614" "64.8" "8.73" "3.59" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "" "22889" "ENSG00000132680" "KHDC4" "hsa:22889; O94981; Q7L7Q2; Q7Z7E9; Q7Z7F0; Q8TBQ0" "" "" "0" "0" "0.997" "1.028" "1.087" "1.113" "1.001" "1.078" "1.122" "1.062" "1.045" "327.7" "326.7" "336.9" "356.3" "364.9" "328.0" "353.2" "367.7" "348.2" "342.4" "" "" "" "" "" "" "" "" "" "" "307.1" "270.4" "312.8" "275.4" "311.0" "313.4" "322.7" "326.5" "348.2" "329.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8144210320745121937" "False" "High" "IsMasterProtein" "Q5T1J5" "Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial OS=Homo sapiens OX=9606 GN=CHCHD2P9 PE=5 SV=1" "0.002" "False" "3.626" "9" "1" "1" "1" "151" "15.5" "9.89" "4.04" "1" "cell organization and biogenesis;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity" "" "" "" "CHCHD2P9" "Q5T1J5" "" "" "0" "0" "1.127" "0.984" "0.996" "1.013" "0.993" "0.982" "0.959" "0.848" "1.036" "188.9" "213.0" "185.8" "188.3" "191.5" "187.6" "185.6" "181.2" "160.2" "195.7" "" "" "" "" "" "" "" "" "" "" "177.0" "176.2" "172.5" "145.5" "163.2" "179.2" "169.5" "160.9" "160.2" "188.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6664937440056635092" "False" "High" "IsMasterProtein" "Q9BQ48" "Large ribosomal subunit protein bL34m OS=Homo sapiens OX=9606 GN=MRPL34 PE=1 SV=1" "0.002" "False" "3.621" "13" "1" "1" "1" "92" "10.2" "12.25" "3.79" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00468" "64981" "ENSG00000130312" "MRPL34" "hsa:64981; Q9BQ48" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.285" "1.103" "1.444" "1.321" "1.231" "1.190" "1.076" "1.131" "1.117" "94.2" "121.1" "104.0" "136.1" "124.5" "116.0" "112.1" "101.4" "106.6" "105.3" "" "" "" "" "" "" "" "" "" "" "88.3" "100.2" "96.5" "105.2" "106.1" "110.8" "102.5" "90.0" "106.6" "101.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3115321329155830276" "False" "High" "IsMasterProtein" "Q9P2D0" "Inhibitor of Bruton tyrosine kinase OS=Homo sapiens OX=9606 GN=IBTK PE=1 SV=3" "0.002" "False" "3.619" "1" "1" "1" "1" "1353" "150.4" "7.71" "3.72" "1" "transport;other biological processes" "other membranes;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00415, Pf00651, Pf12796" "25998" "ENSG00000005700; ENSG00000283068" "IBTK" "hsa:25998; Q2QKU2; Q2QKU3; Q2QKU4; Q5TFD7; Q5TFD9; Q8IUQ9; Q8IUY7; Q8TAI4; Q9HBI8; Q9P2D0; Q9Y3T8" "Genetic causes of porto-sinusoidal vascular disease" "" "1" "0" "1.225" "1.122" "1.549" "1.240" "1.109" "1.296" "1.167" "1.215" "1.163" "88.0" "107.8" "98.7" "136.4" "109.1" "97.6" "114.0" "102.7" "106.9" "102.3" "" "" "" "" "" "" "" "" "" "" "82.5" "89.2" "91.7" "105.4" "93.0" "93.3" "104.2" "91.2" "106.9" "98.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1940772277811891477" "False" "High" "IsMasterProtein" "Q96PM5" "RING finger and CHY zinc finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCHY1 PE=1 SV=1" "0.002" "False" "3.618" "3" "1" "1" "1" "261" "30.1" "6.71" "3.72" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05495, Pf13639, Pf14599" "25898" "ENSG00000163743" "RCHY1" "B3KRG3; C7E541; C7E542; C7E543; D3YRV2; E7EMC8; E7ETW5; J3KPI0; Q2KN33; Q59GN7; Q86X26; Q96PM5; Q96PR5" "Measles virus infection" "Antigen processing: Ubiquitination & Proteasome degradation; Translesion Synthesis by POLH" "3" "0" "1.270" "1.026" "1.003" "0.880" "0.956" "1.205" "0.902" "1.011" "1.035" "99.6" "126.5" "102.2" "99.8" "87.6" "95.2" "120.0" "89.8" "100.6" "103.0" "" "" "" "" "" "" "" "" "" "" "93.3" "104.7" "94.9" "77.2" "74.6" "90.9" "109.7" "79.7" "100.6" "99.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7721582400660787317" "False" "High" "IsMasterProtein" "Q6NVV1" "Putative ribosomal protein uL13-like OS=Homo sapiens OX=9606 GN=RPL13AP3 PE=5 SV=1" "0.002" "False" "3.614" "11" "1" "1" "1" "102" "12.1" "10.76" "3.74" "1" "protein metabolism;other metabolic processes" "translational apparatus;other cell component" "other molecular function" "" "" "" "RPL13AP3" "Q6NVV1" "" "" "0" "0" "1.167" "0.997" "0.883" "0.967" "0.986" "1.056" "0.940" "0.968" "0.983" "135.2" "157.8" "134.8" "119.5" "130.8" "133.3" "142.7" "127.1" "130.9" "132.9" "" "" "" "" "" "" "" "" "" "" "126.7" "130.6" "125.1" "92.4" "111.5" "127.4" "130.4" "112.8" "130.9" "127.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9076326979726242055" "False" "High" "IsMasterProtein" "Q9P2K6" "Kelch-like protein 42 OS=Homo sapiens OX=9606 GN=KLHL42 PE=1 SV=2" "0.002" "False" "3.613" "2" "1" "1" "1" "505" "56.8" "5.74" "3.30" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf01344, Pf07707" "57542" "ENSG00000087448" "KLHL42" "hsa:57542; Q2VPK1; Q8N334; Q9P2K6" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3728877322360888626" "False" "High" "IsMasterProtein" "P62854" "Small ribosomal subunit protein eS26 OS=Homo sapiens OX=9606 GN=RPS26 PE=1 SV=3" "0.002" "False" "3.612" "8" "1" "1" "1" "115" "13.0" "11.00" "3.51" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01283" "6231" "ENSG00000197728" "RPS26" "hsa:6231; P02383; P62854; P70394; Q06722; Q3MHD8; Q6IRY4" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Peptide chain elongation; SRP-dependent cotranslational protein targeting to membrane; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.101" "1.010" "0.996" "0.956" "1.036" "1.050" "1.160" "0.936" "0.967" "152.2" "167.6" "153.7" "151.6" "145.6" "157.7" "159.8" "176.6" "142.4" "147.1" "" "" "" "" "" "" "" "" "" "" "142.6" "138.7" "142.7" "117.2" "124.1" "150.7" "146.0" "156.8" "142.4" "141.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "325955711170823186" "False" "High" "IsMasterProtein" "Q9UIF9" "Bromodomain adjacent to zinc finger domain protein 2A OS=Homo sapiens OX=9606 GN=BAZ2A PE=1 SV=4" "0.002" "False" "3.605" "1" "2" "2" "2" "1905" "211.1" "6.64" "4.87" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf01429, Pf02791, Pf15612, Pf15613" "11176" "ENSG00000076108" "BAZ2A" "B3KN66; hsa:11176; O00536; O15030; Q68DI8; Q96H26; Q9UIF9" "" "NoRC negatively regulates rRNA expression" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4583007171926660229" "False" "High" "IsMasterProtein" "Q9H1I8" "Activating signal cointegrator 1 complex subunit 2 OS=Homo sapiens OX=9606 GN=ASCC2 PE=1 SV=3" "0.002" "False" "3.602" "2" "1" "1" "1" "757" "86.3" "5.16" "3.74" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf02845" "84164" "ENSG00000100325" "ASCC2" "B7Z8E0; F5H6J9; hsa:84164; Q4TT54; Q8TAZ0; Q9H1I8; Q9H711; Q9H9D6" "" "ALKBH3 mediated reversal of alkylation damage" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4571084566871798353" "False" "High" "IsMasterProtein" "Q9Y2S6" "Translation machinery-associated protein 7 OS=Homo sapiens OX=9606 GN=TMA7 PE=1 SV=1" "0.002" "False" "3.602" "14" "1" "3" "1" "64" "7.1" "9.99" "11.52" "1" "" "" "" "Pf09072" "51372" "ENSG00000232112" "TMA7" "hsa:51372; Q9P052; Q9Y2S6" "" "" "0" "0" "0.976" "0.947" "0.914" "0.897" "0.827" "0.850" "0.861" "0.828" "0.854" "1076.0" "1050.2" "1018.5" "983.2" "965.3" "889.6" "914.4" "926.7" "891.0" "919.2" "" "" "" "" "" "" "" "" "" "" "1008.3" "869.1" "945.6" "760.0" "822.8" "849.9" "835.5" "822.8" "891.0" "885.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6257292579144491246" "False" "High" "IsMasterProtein" "Q92544" "Transmembrane 9 superfamily member 4 OS=Homo sapiens OX=9606 GN=TM9SF4 PE=1 SV=2" "0.002" "False" "3.602" "1" "1" "1" "1" "642" "74.5" "6.54" "3.62" "1" "cell adhesion;cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "" "Pf02990" "9777" "ENSG00000101337" "TM9SF4" "B0QYT7; hsa:9777; Q92544; Q9NUA3" "" "" "0" "0" "0.927" "0.947" "1.067" "1.024" "1.001" "1.232" "1.206" "1.170" "1.075" "235.3" "218.2" "222.8" "251.1" "240.9" "235.6" "290.0" "283.7" "275.3" "252.9" "" "" "" "" "" "" "" "" "" "" "220.5" "180.6" "206.9" "194.1" "205.3" "225.1" "265.0" "251.9" "275.3" "243.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1585419871706527859" "False" "High" "IsMasterProtein" "Q8TDY2" "RB1-inducible coiled-coil protein 1 OS=Homo sapiens OX=9606 GN=RB1CC1 PE=1 SV=3" "0.002" "False" "3.601" "1" "1" "1" "1" "1594" "183.0" "5.41" "3.94" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf10377" "9821" "ENSG00000023287" "RB1CC1" "hsa:9821; Q86YR4; Q8TDY2; Q8WVU9; Q92601" "Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "11" "0" "1.020" "1.091" "1.194" "1.107" "1.028" "1.109" "0.986" "0.997" "1.171" "155.6" "158.8" "169.8" "185.9" "172.2" "159.9" "172.6" "153.4" "155.2" "182.2" "" "" "" "" "" "" "" "" "" "" "145.8" "131.4" "157.7" "143.7" "146.8" "152.8" "157.7" "136.2" "155.2" "175.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-378984088295691653" "False" "High" "IsMasterProtein" "P49023" "Paxillin OS=Homo sapiens OX=9606 GN=PXN PE=1 SV=3" "0.002" "False" "3.597" "2" "1" "1" "1" "591" "64.5" "6.19" "3.53" "1" "cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00412, Pf03535" "5829" "ENSG00000089159" "PXN" "B2RAI3; B7ZMB4; hsa:5829; O14970; O14971; O60360; P49023; Q5HYA4" "Integrin-mediated cell adhesion; Prolactin signaling pathway; Androgen receptor network in prostate cancer; Oncostatin M signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; 3q29 copy number variation syndrome; Regulation of actin cytoskeleton; GDNF signaling; HDAC6 interactions in the central nervous system" "VEGFA-VEGFR2 Pathway; GAB1 signalosome; Smooth Muscle Contraction; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Localization of the PINCH-ILK-PARVIN complex to focal adhesions; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "21" "0" "1.132" "1.103" "1.061" "0.974" "1.046" "1.240" "0.984" "1.085" "0.981" "88.3" "100.0" "97.5" "93.8" "86.0" "92.4" "109.6" "86.9" "95.8" "86.6" "" "" "" "" "" "" "" "" "" "" "82.8" "82.8" "90.5" "72.5" "73.3" "88.3" "100.1" "77.2" "95.8" "83.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7700866187711353791" "False" "High" "IsMasterProtein" "Q9P0R6" "GSK3B-interacting protein OS=Homo sapiens OX=9606 GN=GSKIP PE=1 SV=2" "0.002" "False" "3.597" "7" "1" "2" "1" "139" "15.6" "4.48" "5.98" "1" "signal transduction;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf05303" "51527" "ENSG00000100744" "GSKIP" "B3KSZ0; hsa:51527; Q9BST1; Q9NWK0; Q9P0R6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2426417921420304223" "False" "High" "IsMasterProtein" "Q13523" "Serine/threonine-protein kinase PRP4 homolog OS=Homo sapiens OX=9606 GN=PRP4K PE=1 SV=3" "0.002" "False" "3.594" "1" "1" "1" "1" "1007" "116.9" "10.26" "3.81" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8899" "ENSG00000112739" "PRPF4B" "A8K5C9; hsa:8899; Q13523; Q5D0F6; Q5TAY8; Q8IVC3; Q8TDP2; Q96QT7; Q9UEE6" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "846923677132301137" "False" "High" "IsMasterProtein" "Q9UBS8" "E3 ubiquitin-protein ligase RNF14 OS=Homo sapiens OX=9606 GN=RNF14 PE=1 SV=1" "0.002" "False" "3.588" "2" "1" "1" "1" "474" "53.8" "4.75" "4.20" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01485, Pf05773" "9604" "ENSG00000013561" "RNF14" "A0AV26; A6NMR2; A8MTW5; B3KN72; B7ZLV2; D3DQE4; hsa:9604; O94793; Q6IBV0; Q9UBS8" "Androgen receptor signaling pathway" "Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "0.919" "0.959" "0.940" "1.054" "0.952" "0.919" "0.786" "0.804" "1.049" "162.1" "149.1" "155.6" "152.4" "170.9" "154.3" "149.1" "127.4" "130.3" "170.1" "" "" "" "" "" "" "" "" "" "" "151.9" "123.4" "144.4" "117.8" "145.7" "147.4" "136.2" "113.1" "130.3" "163.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4229859227879041997" "False" "High" "IsMasterProtein" "P16278" "Beta-galactosidase OS=Homo sapiens OX=9606 GN=GLB1 PE=1 SV=2" "0.002" "False" "3.587" "2" "1" "1" "1" "677" "76.0" "6.57" "2.78" "1" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01301, Pf21317, Pf21467" "2720" "ENSG00000170266" "GLB1" "B2R7H8; B7Z6B0; hsa:2720; P16278; P16279" "Ectoderm differentiation; Degradation pathway of sphingolipids, including diseases; Ciliary landscape; Glycosaminoglycan degradation; Sphingolipid metabolism in senescence" "Neutrophil degranulation; HS-GAG degradation; Sialic acid metabolism; Glycosphingolipid catabolism; Keratan sulfate degradation; Defective NEU1 causes sialidosis; MPS IV - Morquio syndrome B" "12" "0" "1.240" "1.116" "1.036" "1.127" "1.091" "1.017" "1.088" "1.156" "1.092" "123.0" "152.6" "137.3" "127.5" "138.7" "134.3" "125.2" "133.9" "142.2" "134.3" "" "" "" "" "" "" "" "" "" "" "115.3" "126.3" "127.5" "98.6" "118.2" "128.3" "114.4" "118.9" "142.2" "129.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2858860997982508935" "False" "High" "IsMasterProtein" "Q99757" "Thioredoxin, mitochondrial OS=Homo sapiens OX=9606 GN=TXN2 PE=1 SV=2" "0.002" "False" "3.585" "6" "1" "3" "1" "166" "18.4" "8.29" "7.26" "1" "stress response;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00085" "25828" "ENSG00000100348" "TXN2" "hsa:25828; Q5JZA0; Q6FH60; Q99757; Q9UH29" "Oxidative stress response" "Detoxification of Reactive Oxygen Species; Degradation of cysteine and homocysteine" "3" "0" "0.974" "1.091" "1.232" "1.172" "0.996" "1.265" "1.307" "0.936" "1.207" "49.0" "47.7" "53.4" "60.3" "57.4" "48.8" "62.0" "64.1" "45.8" "59.2" "" "" "" "" "" "" "" "" "" "" "45.9" "39.5" "49.6" "46.7" "48.9" "46.6" "56.6" "56.9" "45.8" "57.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2087285006199939008" "False" "High" "IsMasterProtein" "P61626" "Lysozyme C OS=Homo sapiens OX=9606 GN=LYZ PE=1 SV=1" "0.002" "False" "3.584" "6" "1" "1" "1" "148" "16.5" "9.16" "3.81" "1" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00062" "4069" "ENSG00000090382" "LYZ" "hsa:4069; P00695; P61626; Q13170; Q9UCF8" "Macrophage markers; Pancreatic cancer subtypes" "Neutrophil degranulation; Amyloid fiber formation; Antimicrobial peptides" "5" "0" "0.954" "0.890" "0.802" "0.891" "0.884" "0.859" "0.913" "0.908" "0.825" "324.9" "310.1" "289.2" "260.5" "289.6" "287.3" "279.3" "296.6" "295.0" "267.9" "" "" "" "" "" "" "" "" "" "" "304.5" "256.6" "268.5" "201.4" "246.8" "274.5" "255.2" "263.4" "295.0" "258.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7828527280741994957" "False" "High" "IsMasterProtein" "O75971" "snRNA-activating protein complex subunit 5 OS=Homo sapiens OX=9606 GN=SNAPC5 PE=1 SV=1" "0.002" "False" "3.583" "9" "1" "1" "1" "98" "11.3" "4.58" "3.16" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf15497" "10302" "ENSG00000174446" "SNAPC5" "A8K7N6; hsa:10302; O75971; Q96CF3" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2133311852660354058" "False" "High" "IsMasterProtein" "P49795" "Regulator of G-protein signaling 19 OS=Homo sapiens OX=9606 GN=RGS19 PE=1 SV=1" "0.002" "False" "3.579" "5" "1" "1" "1" "217" "24.6" "5.62" "3.60" "1" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00615" "10287" "ENSG00000171700" "RGS19" "A8K216; E1P5G9; hsa:10287; P49795; Q53XN0; Q8TD60" "Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9173522146093415156" "False" "High" "IsMasterProtein" "Q9P0J7" "E3 ubiquitin-protein ligase KCMF1 OS=Homo sapiens OX=9606 GN=KCMF1 PE=1 SV=2" "0.002" "False" "3.578" "2" "1" "2" "1" "381" "41.9" "5.66" "7.88" "1" "cell-cell signaling" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00569, Pf05605" "56888" "ENSG00000176407" "KCMF1" "Q4ZG04; Q53SC7; Q9BWK2; Q9H8P5; Q9P0J7; Q9UFE8" "" "Neutrophil degranulation" "1" "0" "0.933" "0.898" "0.986" "0.914" "0.978" "0.862" "0.863" "0.844" "0.942" "447.1" "417.3" "401.7" "441.0" "408.5" "437.2" "385.6" "386.0" "377.4" "421.3" "" "" "" "" "" "" "" "" "" "" "419.0" "345.3" "372.9" "340.9" "348.2" "417.7" "352.4" "342.7" "377.4" "405.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6336479457055724127" "False" "High" "IsMasterProtein" "Q9UQ84" "Exonuclease 1 OS=Homo sapiens OX=9606 GN=EXO1 PE=1 SV=2" "0.002" "False" "3.575" "1" "1" "1" "1" "846" "94.0" "8.31" "3.67" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf00752, Pf00867" "9156" "ENSG00000174371" "EXO1" "hsa:9156; O60545; O75214; O75466; Q5T396; Q96IJ1; Q9UG38; Q9UNW0; Q9UQ84" "DNA repair pathways, full network; DNA mismatch repair; Primary ovarian insufficiency" "Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "19" "0" "0.998" "0.929" "0.919" "0.929" "0.946" "1.032" "0.851" "0.837" "1.006" "187.3" "187.0" "173.9" "172.1" "174.0" "177.1" "193.3" "159.3" "156.8" "188.4" "" "" "" "" "" "" "" "" "" "" "175.5" "154.7" "161.5" "133.0" "148.3" "169.2" "176.6" "141.4" "156.8" "181.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6656067604424276740" "False" "High" "IsMasterProtein" "O95365" "Zinc finger and BTB domain-containing protein 7A OS=Homo sapiens OX=9606 GN=ZBTB7A PE=1 SV=1" "0.002" "False" "3.574" "2" "1" "1" "1" "584" "61.4" "5.19" "4.08" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "51341" "ENSG00000178951" "ZBTB7A" "D6W619; hsa:51341; O00456; O95365; Q14D41; Q5XG86" "IL-18 signaling pathway" "" "1" "0" "1.283" "1.028" "1.050" "1.111" "1.124" "1.041" "0.815" "0.921" "0.989" "52.8" "67.8" "54.3" "55.5" "58.7" "59.4" "55.0" "43.1" "48.7" "52.3" "" "" "" "" "" "" "" "" "" "" "49.5" "56.1" "50.4" "42.9" "50.1" "56.7" "50.3" "38.2" "48.7" "50.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2740233867527592751" "False" "High" "IsMasterProtein" "Q5M775" "Cytospin-B OS=Homo sapiens OX=9606 GN=SPECC1 PE=1 SV=1" "0.002" "False" "3.574" "1" "2" "2" "1" "1068" "118.5" "6.70" "6.38" "2" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf00307" "92521" "ENSG00000128487" "SPECC1" "B4DHH0; B7WNS8; hsa:92521; Q5IBP1; Q5IBP2; Q5IBP3; Q5IBP4; Q5M772; Q5M773; Q5M774; Q5M775; Q86XT8; Q8N4U4; Q8WU84; Q9HCQ3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1884707447535219714" "False" "High" "IsMasterProtein" "Q9BYM8" "RanBP-type and C3HC4-type zinc finger-containing protein 1 OS=Homo sapiens OX=9606 GN=RBCK1 PE=1 SV=2" "0.002" "False" "3.573" "2" "1" "1" "1" "510" "57.5" "5.67" "3.34" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13445" "10616" "ENSG00000125826" "RBCK1" "O95623; Q86SL2; Q96BS3; Q9BYM8; Q9BYM9" "TAR syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4105877346039324927" "False" "High" "IsMasterProtein" "Q9BV29" "Coiled-coil domain-containing protein 32 OS=Homo sapiens OX=9606 GN=CCDC32 PE=1 SV=2" "0.002" "False" "3.570" "5" "1" "1" "1" "185" "20.6" "4.53" "4.13" "1" "cell organization and biogenesis;other biological processes" "other membranes" "" "Pf14989" "90416" "ENSG00000128891" "CCDC32" "A8KAL4; Q86TC4; Q8N788; Q8NAR7; Q9BV29" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8022290740510184659" "False" "High" "IsMasterProtein" "P49257" "Protein ERGIC-53 OS=Homo sapiens OX=9606 GN=LMAN1 PE=1 SV=2" "0.002" "False" "3.568" "3" "2" "2" "1" "510" "57.5" "6.77" "2.50" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf03388" "3998" "ENSG00000074695" "LMAN1" "hsa:3998; P49257; Q12895; Q8N5I7; Q9UQG1; Q9UQG2; Q9UQG3; Q9UQG4; Q9UQG5; Q9UQG6; Q9UQG7; Q9UQG8; Q9UQG9; Q9UQH0; Q9UQH1; Q9UQH2" "VEGFA-VEGFR2 signaling; Dengue-2 interactions with complement and coagulation cascades; Complement and coagulation cascades" "RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle; RAC3 GTPase cycle; COPII-mediated vesicle transport; Cargo concentration in the ER; Transport to the Golgi and subsequent modification" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5042642415102067907" "False" "High" "IsMasterProtein" "Q99549" "M-phase phosphoprotein 8 OS=Homo sapiens OX=9606 GN=MPHOSPH8 PE=1 SV=2" "0.002" "False" "3.567" "2" "2" "2" "2" "860" "97.1" "6.06" "4.49" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00385, Pf12796" "54737" "ENSG00000196199" "MPHOSPH8" "B7Z6F9; hsa:54737; Q5JPE5; Q5JTQ0; Q86TK3; Q96MK4; Q99549; Q9BTP1" "" "" "0" "0" "1.328" "1.160" "1.368" "1.163" "1.155" "1.635" "1.211" "1.450" "1.228" "39.5" "52.4" "45.8" "54.0" "45.9" "45.6" "64.5" "47.8" "57.2" "48.4" "" "" "" "" "" "" "" "" "" "" "37.0" "43.4" "42.5" "41.7" "39.1" "43.6" "59.0" "42.4" "57.2" "46.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3472169871785604282" "False" "High" "IsMasterProtein" "P61009" "Signal peptidase complex subunit 3 OS=Homo sapiens OX=9606 GN=SPCS3 PE=1 SV=1" "0.002" "False" "3.560" "5" "1" "1" "1" "180" "20.3" "8.62" "3.92" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi" "" "Pf04573" "60559" "ENSG00000129128" "SPCS3" "hsa:60559; P12280; P61009; Q9H0S7" "15q25 copy number variation" "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP); Maturation of hRSV A proteins; Synthesis, secretion, and deacylation of Ghrelin; SRP-dependent cotranslational protein targeting to membrane" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7556059928236931209" "False" "High" "IsMasterProtein" "Q86T82" "Ubiquitin carboxyl-terminal hydrolase 37 OS=Homo sapiens OX=9606 GN=USP37 PE=1 SV=2" "0.002" "False" "3.557" "2" "2" "2" "2" "979" "110.1" "6.20" "3.41" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf02809, Pf16674" "57695" "ENSG00000135913" "USP37" "A2RUQ8; B7ZM38; B7ZM41; E9PHL3; hsa:57695; Q2KHT2; Q53S10; Q7Z3A5; Q86T82; Q9HCH8" "Warburg effect modulated by deubiquitinating enzymes and their substrates" "Ub-specific processing proteases" "2" "0" "1.042" "1.143" "1.067" "1.174" "1.006" "0.925" "0.905" "0.908" "0.946" "276.4" "288.1" "315.8" "294.8" "324.5" "278.2" "255.7" "250.1" "251.0" "261.5" "" "" "" "" "" "" "" "" "" "" "259.0" "238.4" "293.2" "227.9" "276.6" "265.8" "233.7" "222.1" "251.0" "251.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6627210930524934042" "False" "High" "IsMasterProtein" "Q8TCF1" "AN1-type zinc finger protein 1 OS=Homo sapiens OX=9606 GN=ZFAND1 PE=1 SV=1" "0.002" "False" "3.557" "4" "1" "1" "1" "268" "30.8" "7.39" "3.99" "1" "cell organization and biogenesis;other biological processes" "other cell component" "other molecular function" "Pf01428" "79752" "ENSG00000104231" "ZFAND1" "E5RIG0; E5RJ99; hsa:79752; Q658R7; Q6IA32; Q6PGQ6; Q8TCF1; Q9H810" "" "" "0" "0" "1.092" "0.889" "0.987" "1.008" "1.022" "0.966" "0.945" "1.050" "1.048" "187.0" "204.1" "166.2" "184.6" "188.4" "191.0" "180.6" "176.7" "196.4" "195.9" "" "" "" "" "" "" "" "" "" "" "175.2" "168.9" "154.3" "142.7" "160.6" "182.5" "165.0" "156.9" "196.4" "188.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2903433267102321467" "False" "High" "IsMasterProtein" "Q9UL03" "Integrator complex subunit 6 OS=Homo sapiens OX=9606 GN=INTS6 PE=1 SV=1" "0.002" "False" "3.555" "1" "1" "1" "1" "887" "100.3" "8.62" "2.33" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "other molecular function" "Pf13519, Pf15300" "26512" "ENSG00000102786" "INTS6" "hsa:26512; Q0P664; Q6PJP4; Q9UFK0; Q9UL03; Q9Y5M9" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5546431663136658050" "False" "High" "IsMasterProtein" "Q9UK39" "Nocturnin OS=Homo sapiens OX=9606 GN=NOCT PE=1 SV=2" "0.002" "False" "3.553" "3" "1" "2" "1" "431" "48.2" "7.23" "6.03" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372" "25819" "ENSG00000151014" "NOCT" "D3DNY5; hsa:25819; Q14D51; Q9HD93; Q9HD94; Q9HD95; Q9UK39" "Orexin receptor pathway" "BMAL1:CLOCK,NPAS2 activates circadian gene expression" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6933895130976224833" "False" "High" "IsMasterProtein" "P23511" "Nuclear transcription factor Y subunit alpha OS=Homo sapiens OX=9606 GN=NFYA PE=1 SV=2" "0.002" "False" "3.552" "5" "1" "1" "1" "347" "36.9" "8.94" "3.70" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02045" "4800" "ENSG00000001167" "NFYA" "hsa:4800; P23511; Q8IXU0" "Sterol regulatory element-binding proteins (SREBP) signaling; Wnt signaling pathway and pluripotency; Sudden infant death syndrome (SIDS) susceptibility pathways" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum stress; ATF6 (ATF6-alpha) activates chaperone genes" "8" "0" "0.951" "1.103" "0.999" "1.191" "1.000" "0.984" "0.900" "0.954" "0.936" "35.8" "34.1" "39.5" "35.8" "42.7" "35.8" "35.3" "32.3" "34.2" "33.5" "" "" "" "" "" "" "" "" "" "" "33.6" "28.2" "36.7" "27.7" "36.4" "34.2" "32.2" "28.6" "34.2" "32.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "688156256911313488" "False" "High" "IsMasterProtein" "Q5T0N5" "Formin-binding protein 1-like OS=Homo sapiens OX=9606 GN=FNBP1L PE=1 SV=3" "0.002" "False" "3.550" "2" "2" "2" "2" "605" "70.0" "6.64" "2.40" "2" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00018, Pf00611" "54874" "ENSG00000137942" "FNBP1L" "hsa:54874; J3QSS4; Q5T0N5; Q5T0N6; Q6B097; Q6P653; Q6R4Q4; Q9NXG1" "" "CDC42 GTPase cycle; RHOJ GTPase cycle; Clathrin-mediated endocytosis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4021851569600186030" "False" "High" "IsMasterProtein" "A2A288" "Probable ribonuclease ZC3H12D OS=Homo sapiens OX=9606 GN=ZC3H12D PE=1 SV=3" "0.002" "False" "3.549" "5" "2" "2" "2" "527" "58.0" "8.68" "5.72" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11977, Pf18039" "340152" "ENSG00000178199" "ZC3H12D" "A1L178; A2A288; B2RXF4; B7WNU7; B9ZZP9; B9ZZQ0; hsa:340152; Q6ZRW2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4156627100779081460" "False" "High" "IsMasterProtein" "Q02446" "Transcription factor Sp4 OS=Homo sapiens OX=9606 GN=SP4 PE=1 SV=2" "0.002" "False" "3.547" "3" "1" "1" "1" "784" "81.9" "7.05" "3.93" "1" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6671" "ENSG00000105866" "SP4" "hsa:6671; O60402; Q02446; Q32M52" "" "" "0" "0" "0.987" "0.810" "1.248" "1.299" "0.897" "1.261" "1.056" "1.139" "1.114" "15.3" "15.1" "12.4" "19.0" "19.8" "13.7" "19.2" "16.1" "17.4" "17.0" "" "" "" "" "" "" "" "" "" "" "14.3" "12.5" "11.5" "14.7" "16.9" "13.1" "17.6" "14.3" "17.4" "16.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7714600249941919632" "False" "High" "IsMasterProtein" "O95562" "Vesicle transport protein SFT2B OS=Homo sapiens OX=9606 GN=SFT2D2 PE=1 SV=1" "0.002" "False" "3.542" "6" "1" "1" "1" "160" "17.8" "9.13" "3.58" "1" "transport" "other membranes" "" "Pf04178" "375035" "ENSG00000213064" "SFT2D2" "A8K2R0; hsa:375035; O95562; Q6UWR8" "TYROBP causal network in microglia" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3917086936507081280" "False" "High" "IsMasterProtein" "Q56P03" "E2F-associated phosphoprotein OS=Homo sapiens OX=9606 GN=EAPP PE=1 SV=4" "0.002" "False" "3.537" "5" "1" "1" "1" "285" "32.7" "5.12" "2.91" "1" "other biological processes" "nucleus;other cell component" "" "Pf10238" "55837" "ENSG00000129518" "EAPP" "hsa:55837; Q56P03; Q9BVF4; Q9NWV5; Q9NZ86" "" "" "0" "0" "0.991" "0.913" "1.094" "1.147" "0.944" "0.859" "0.983" "0.994" "1.064" "93.8" "93.0" "85.6" "102.7" "107.7" "88.5" "80.6" "92.2" "93.3" "99.9" "" "" "" "" "" "" "" "" "" "" "87.9" "77.0" "79.5" "79.4" "91.8" "84.6" "73.6" "81.9" "93.3" "96.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3449420204754272229" "False" "High" "IsMasterProtein" "Q9NV56" "MRG/MORF4L-binding protein OS=Homo sapiens OX=9606 GN=MRGBP PE=1 SV=1" "0.002" "False" "3.537" "6" "1" "2" "1" "204" "22.4" "5.83" "5.30" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf07904" "55257" "ENSG00000101189" "MRGBP" "A8C4L5; hsa:55257; Q9NV56" "" "HATs acetylate histones" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6896293366325971592" "False" "High" "IsMasterProtein" "Q8WWK9" "Cytoskeleton-associated protein 2 OS=Homo sapiens OX=9606 GN=CKAP2 PE=1 SV=1" "0.002" "False" "3.533" "2" "2" "2" "2" "683" "76.9" "9.41" "4.92" "2" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "" "Pf15297" "26586" "ENSG00000136108" "CKAP2" "A2BDE0; A5YM58; B4DR35; E9PD90; hsa:26586; Q3KRA5; Q5VXB4; Q8IWV5; Q8IWV6; Q8WWK9; Q96FH9; Q9H012; Q9H0D0; Q9H988; Q9HC49; Q9NVG4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5520460410914984228" "False" "High" "IsMasterProtein" "Q9NSG2" "FIGNL1-interacting regulator of recombination and mitosis OS=Homo sapiens OX=9606 GN=FIRRM PE=1 SV=1" "0.002" "False" "3.532" "1" "1" "1" "1" "853" "96.5" "6.00" "3.09" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf14868" "55732" "ENSG00000000460" "FIRRM" "A6NFP1; B3KU42; hsa:55732; Q3KNQ1; Q9H8L5; Q9NSG2; Q9NVJ0" "" "" "0" "0" "0.942" "0.978" "1.091" "1.105" "0.931" "1.069" "1.008" "0.929" "0.918" "138.7" "130.7" "135.6" "151.2" "153.3" "129.1" "148.3" "139.8" "128.8" "127.3" "" "" "" "" "" "" "" "" "" "" "130.0" "108.1" "125.9" "116.9" "130.6" "123.4" "135.5" "124.1" "128.8" "122.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "790409286945352523" "False" "High" "IsMasterProtein" "O14893" "Gem-associated protein 2 OS=Homo sapiens OX=9606 GN=GEMIN2 PE=1 SV=1" "0.002" "False" "3.532" "4" "1" "1" "1" "280" "31.6" "5.58" "3.55" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04938" "8487" "ENSG00000092208" "GEMIN2" "B2R9W8; hsa:8487; O14893; Q2M3B3; Q9H4F5; Q9NS77; Q9NS78; Q9NS79" "" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8893746772392115503" "False" "High" "IsMasterProtein" "Q6P1L5" "Protein FAM117B OS=Homo sapiens OX=9606 GN=FAM117B PE=1 SV=2" "0.002" "False" "3.531" "2" "1" "1" "1" "589" "61.9" "9.82" "3.68" "1" "" "" "" "Pf15388" "150864" "ENSG00000138439" "FAM117B" "hsa:150864; Q53QZ5; Q585T9; Q6P1L5; Q8N8W1; Q96Q34" "" "" "0" "0" "1.027" "0.850" "1.004" "0.979" "0.982" "0.861" "0.875" "0.882" "0.871" "134.4" "138.0" "114.2" "134.9" "131.5" "131.9" "115.7" "117.5" "118.5" "117.1" "" "" "" "" "" "" "" "" "" "" "125.9" "114.2" "106.0" "104.3" "112.1" "126.0" "105.7" "104.3" "118.5" "112.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4968943538571685199" "False" "High" "IsMasterProtein" "Q96GC5" "Large ribosomal subunit protein mL48 OS=Homo sapiens OX=9606 GN=MRPL48 PE=1 SV=2" "0.002" "False" "3.529" "6" "1" "1" "1" "212" "23.9" "8.98" "3.84" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf00338" "51642" "ENSG00000175581" "MRPL48" "B4DN34; hsa:51642; Q49AK7; Q4U2Q4; Q96GC5; Q9P091; Q9Y5J0" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.932" "0.879" "1.122" "1.027" "0.968" "1.020" "1.121" "1.069" "1.002" "132.2" "123.1" "116.2" "148.3" "135.7" "128.0" "134.8" "148.2" "141.3" "132.5" "" "" "" "" "" "" "" "" "" "" "123.9" "101.9" "107.8" "114.6" "115.7" "122.3" "123.2" "131.6" "141.3" "127.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4634440829805379897" "False" "High" "IsMasterProtein" "Q02224" "Centromere-associated protein E OS=Homo sapiens OX=9606 GN=CENPE PE=1 SV=2" "0.002" "False" "3.516" "0" "1" "1" "1" "2701" "316.2" "5.64" "3.66" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "1062" "ENSG00000138778" "CENPE" "A6NKY9; A8K2U7; hsa:1062; Q02224; Q4LE75" "Regulation of sister chromatid separation at the metaphase-anaphase transition" "RHO GTPases Activate Formins; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "10" "0" "1.018" "0.966" "0.989" "1.012" "1.017" "0.963" "0.868" "0.964" "0.962" "169.9" "172.9" "164.1" "168.1" "171.9" "172.7" "163.6" "147.5" "163.8" "163.5" "" "" "" "" "" "" "" "" "" "" "159.2" "143.1" "152.3" "129.9" "146.5" "165.0" "149.5" "131.0" "163.8" "157.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8000898244145096963" "False" "High" "IsMasterProtein" "Q16533" "snRNA-activating protein complex subunit 1 OS=Homo sapiens OX=9606 GN=SNAPC1 PE=1 SV=1" "0.002" "False" "3.513" "5" "2" "2" "2" "368" "43.0" "9.51" "5.24" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09808" "6617" "ENSG00000023608" "SNAPC1" "hsa:6617; Q16533" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes" "3" "0" "1.007" "1.062" "1.055" "1.114" "0.972" "0.931" "0.940" "0.943" "1.071" "211.2" "212.7" "224.4" "222.9" "235.2" "205.2" "196.6" "198.6" "199.1" "226.2" "" "" "" "" "" "" "" "" "" "" "197.9" "176.0" "208.3" "172.3" "200.5" "196.0" "179.6" "176.3" "199.1" "217.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1701299476432316153" "False" "High" "IsMasterProtein" "Q9BU61" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 OS=Homo sapiens OX=9606 GN=NDUFAF3 PE=1 SV=1" "0.002" "False" "3.513" "6" "1" "1" "1" "184" "20.3" "8.22" "4.49" "1" "cell organization and biogenesis" "other membranes;mitochondrion;nucleus" "" "Pf04430" "25915" "ENSG00000178057" "NDUFAF3" "hsa:25915; Q9BU61" "" "Complex I biogenesis" "1" "0" "0.964" "0.951" "0.937" "1.006" "1.014" "0.896" "1.025" "0.952" "1.021" "287.3" "277.0" "273.1" "269.3" "289.1" "291.5" "257.5" "294.4" "273.5" "293.3" "" "" "" "" "" "" "" "" "" "" "269.2" "229.3" "253.6" "208.2" "246.4" "278.5" "235.3" "261.4" "273.5" "282.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4875148632163355861" "False" "High" "IsMasterProtein" "Q9Y3D2" "Methionine-R-sulfoxide reductase B2, mitochondrial OS=Homo sapiens OX=9606 GN=MSRB2 PE=1 SV=2" "0.002" "False" "3.512" "5" "1" "1" "1" "182" "19.5" "8.63" "4.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf01641" "22921" "ENSG00000148450" "MSRB2" "hsa:22921; Q17R44; Q4G1C7; Q9Y3D2; Q9Y5W6" "Sulindac metabolic pathway; Methionine de novo and salvage pathway" "Protein repair" "3" "0" "1.008" "0.942" "0.992" "0.967" "0.889" "0.963" "0.941" "0.925" "0.885" "395.8" "398.9" "372.9" "392.7" "382.9" "351.9" "381.3" "372.4" "366.2" "350.5" "" "" "" "" "" "" "" "" "" "" "370.9" "330.1" "346.2" "303.6" "326.3" "336.2" "348.4" "330.7" "366.2" "337.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4967759419043337591" "False" "High" "IsMasterProtein" "Q9UJ83" "2-hydroxyacyl-CoA lyase 1 OS=Homo sapiens OX=9606 GN=HACL1 PE=1 SV=2" "0.002" "False" "3.511" "2" "1" "1" "1" "578" "63.7" "7.36" "3.50" "1" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00205, Pf02775, Pf02776" "26061" "ENSG00000131373" "HACL1" "B4DWI1; B4DXI5; E9PEN4; hsa:26061; Q9BV42; Q9P0A2; Q9UJ83" "" "Peroxisomal protein import; Alpha-oxidation of phytanate" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1411414456407117859" "False" "High" "IsMasterProtein" "Q7Z6K3" "Protein prenyltransferase alpha subunit repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=PTAR1 PE=1 SV=2" "0.002" "False" "3.511" "6" "2" "2" "2" "402" "46.4" "6.99" "2.91" "2" "" "other cell component" "other molecular function" "Pf01239" "375743" "ENSG00000188647" "PTAR1" "hsa:375743; Q5T7V5; Q5T7V6; Q7Z6K3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1677605172328813102" "False" "High" "IsMasterProtein" "Q6IAA8" "Ragulator complex protein LAMTOR1 OS=Homo sapiens OX=9606 GN=LAMTOR1 PE=1 SV=2" "0.002" "False" "3.509" "8" "1" "1" "1" "161" "17.7" "5.15" "2.42" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15454" "55004" "ENSG00000149357" "LAMTOR1" "hsa:55004; Q6IAA8; Q8WZ09; Q9NWT0" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "Regulation of PTEN gene transcription; mTORC1-mediated signalling; Neutrophil degranulation; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; Amino acids regulate mTORC1; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOH GTPase cycle" "17" "0" "1.062" "1.109" "1.407" "1.022" "1.355" "1.058" "0.895" "1.111" "1.143" "30.3" "32.2" "33.6" "42.6" "31.0" "41.0" "32.0" "27.1" "33.6" "34.6" "" "" "" "" "" "" "" "" "" "" "28.4" "26.6" "31.2" "32.9" "26.4" "39.2" "29.3" "24.1" "33.6" "33.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2134905287649132421" "False" "High" "IsMasterProtein" "Q9Y312" "Protein AAR2 homolog OS=Homo sapiens OX=9606 GN=AAR2 PE=1 SV=2" "0.002" "False" "3.506" "4" "2" "2" "2" "384" "43.4" "5.96" "5.67" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf05282, Pf20981" "25980" "ENSG00000131043" "AAR2" "E1P5S7; hsa:25980; Q9H4F9; Q9P1P3; Q9UFK9; Q9Y312" "Ciliary landscape" "" "1" "0" "1.032" "0.981" "1.019" "0.903" "0.903" "0.960" "0.842" "0.900" "0.939" "674.8" "696.6" "661.7" "687.4" "609.4" "609.4" "647.9" "568.2" "607.5" "633.8" "" "" "" "" "" "" "" "" "" "" "632.3" "576.4" "614.3" "531.4" "519.4" "582.3" "592.0" "504.5" "607.5" "610.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "783704005019212775" "False" "High" "IsMasterProtein" "Q8IZ21" "Phosphatase and actin regulator 4 OS=Homo sapiens OX=9606 GN=PHACTR4 PE=1 SV=1" "0.002" "False" "3.505" "1" "1" "1" "1" "702" "78.2" "6.62" "3.58" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf02755" "65979" "ENSG00000204138" "PHACTR4" "A2APK6; B9ZVW0; D3DPM3; hsa:65979; Q68DD4; Q6NUN6; Q8IZ21; Q8N384; Q9H395; Q9H6X0; Q9H8W6" "" "" "0" "0" "0.923" "1.024" "0.995" "0.925" "0.957" "1.070" "0.959" "0.980" "0.907" "96.7" "89.2" "99.0" "96.1" "89.4" "92.5" "103.4" "92.7" "94.7" "87.6" "" "" "" "" "" "" "" "" "" "" "90.6" "73.9" "91.9" "74.3" "76.2" "88.3" "94.5" "82.3" "94.7" "84.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7554911446023016001" "False" "High" "IsMasterProtein" "P51668" "Ubiquitin-conjugating enzyme E2 D1 OS=Homo sapiens OX=9606 GN=UBE2D1 PE=1 SV=1" "0.002" "False" "3.504" "7" "1" "1" "1" "147" "16.6" "7.42" "3.97" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7321" "ENSG00000072401" "UBE2D1" "A6NLF6; A8K786; hsa:7321; P51668" "Proteasome degradation" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; CLEC7A (Dectin-1) signaling; CDK-mediated phosphorylation and removal of Cdc6; Neddylation; Peroxisomal protein import; IKK complex recruitment mediated by RIP1; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Signaling by BMP; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects; Inactivation of CSF3 (G-CSF) signaling; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Ovarian tumor domain proteases" "35" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1753362023353680935" "False" "High" "IsMasterProtein" "Q8WY91" "Peroxynitrite isomerase THAP4 OS=Homo sapiens OX=9606 GN=THAP4 PE=1 SV=2" "0.002" "False" "3.501" "2" "1" "1" "1" "577" "62.9" "9.28" "3.65" "1" "other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05485, Pf08768" "51078" "ENSG00000176946" "THAP4" "hsa:51078; Q53NU7; Q6GRN0; Q6IPJ3; Q8WY91; Q9NW26; Q9Y325" "2q37 copy number variation syndrome" "" "1" "0" "1.011" "0.940" "0.904" "0.941" "0.911" "1.056" "0.913" "1.013" "0.978" "114.0" "115.2" "107.1" "103.0" "107.2" "103.8" "120.4" "104.1" "115.4" "111.5" "" "" "" "" "" "" "" "" "" "" "106.8" "95.4" "99.5" "79.7" "91.4" "99.2" "110.0" "92.4" "115.4" "107.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1243258225011339674" "False" "High" "IsMasterProtein" "Q9NP87" "DNA-directed DNA/RNA polymerase mu OS=Homo sapiens OX=9606 GN=POLM PE=1 SV=1" "0.002" "False" "3.500" "4" "2" "2" "2" "494" "54.8" "8.41" "2.31" "2" "DNA metabolism;other metabolic processes;stress response" "nucleus" "nucleic acid binding activity;other molecular function" "Pf10391, Pf14716, Pf14791, Pf14792" "27434" "ENSG00000122678" "POLM" "D3DVK4; hsa:27434; Q6P5X8; Q86WQ9; Q9NP87" "Non-homologous end joining; DNA repair pathways, full network" "Nonhomologous End-Joining (NHEJ)" "3" "0" "1.075" "1.056" "1.021" "0.826" "0.821" "0.781" "0.900" "0.809" "0.830" "686.8" "738.5" "725.1" "701.3" "567.1" "563.8" "536.2" "618.2" "555.7" "570.1" "" "" "" "" "" "" "" "" "" "" "643.5" "611.1" "673.1" "542.1" "483.4" "538.6" "489.9" "548.9" "555.7" "548.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7392710609967527407" "False" "High" "IsMasterProtein" "Q96BH1" "E3 ubiquitin-protein ligase RNF25 OS=Homo sapiens OX=9606 GN=RNF25 PE=1 SV=1" "0.002" "False" "3.499" "2" "1" "2" "1" "459" "51.2" "6.54" "6.85" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus" "other molecular function" "Pf05773, Pf13639" "64320" "ENSG00000163481" "RNF25" "A8K0D6; hsa:64320; Q53HQ5; Q96BH1; Q9H874" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.177" "1.052" "1.144" "1.099" "1.057" "1.141" "1.003" "1.087" "1.061" "99.0" "116.5" "104.1" "113.3" "108.8" "104.6" "113.0" "99.3" "107.6" "105.1" "" "" "" "" "" "" "" "" "" "" "92.8" "96.4" "96.7" "87.6" "92.7" "100.0" "103.2" "88.2" "107.6" "101.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8737187814280018253" "False" "High" "IsMasterProtein" "Q86SQ7" "Serologically defined colon cancer antigen 8 OS=Homo sapiens OX=9606 GN=SDCCAG8 PE=1 SV=1" "0.002" "False" "3.496" "1" "1" "1" "1" "713" "82.6" "5.81" "3.68" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf15964" "10806" "ENSG00000054282; ENSG00000276111" "SDCCAG8" "O60527; Q3ZCR6; Q86SQ7; Q8N5F2; Q9P0F1" "Ciliopathies; 16p11.2 distal deletion syndrome; Bardet-Biedl syndrome" "Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane" "10" "0" "1.073" "0.916" "1.002" "1.044" "1.072" "0.912" "0.983" "0.901" "1.062" "206.3" "221.3" "189.1" "206.8" "215.4" "221.2" "188.3" "202.8" "186.0" "219.1" "" "" "" "" "" "" "" "" "" "" "193.3" "183.1" "175.5" "159.9" "183.6" "211.3" "172.0" "180.1" "186.0" "211.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3585506896184313716" "False" "High" "IsMasterProtein" "P63218" "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 OS=Homo sapiens OX=9606 GN=GNG5 PE=1 SV=3" "0.002" "False" "3.494" "13" "1" "1" "1" "68" "7.3" "9.85" "3.67" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00631" "2787" "ENSG00000174021" "GNG5" "B2R5A0; hsa:2787; P30670; P63218; Q5VX54; Q61015" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells; Pathways in cancer" "G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "36" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6351982484354438023" "False" "High" "IsMasterProtein" "Q96E14" "RecQ-mediated genome instability protein 2 OS=Homo sapiens OX=9606 GN=RMI2 PE=1 SV=2" "0.002" "False" "3.494" "11" "2" "2" "2" "147" "15.9" "7.90" "5.86" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf16100" "116028" "ENSG00000175643" "RMI2" "B3KVZ6; hsa:116028; Q49AE2; Q8TBL0; Q96E14" "" "Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "14" "0" "0.997" "0.948" "1.021" "0.974" "1.023" "1.021" "0.972" "0.928" "0.995" "571.2" "569.7" "541.7" "583.0" "556.1" "584.4" "583.3" "555.4" "529.8" "568.4" "" "" "" "" "" "" "" "" "" "" "535.2" "471.4" "502.9" "450.7" "474.0" "558.4" "533.0" "493.2" "529.8" "547.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7765133988428364561" "False" "High" "IsMasterProtein" "Q58WW2" "DDB1- and CUL4-associated factor 6 OS=Homo sapiens OX=9606 GN=DCAF6 PE=1 SV=1" "0.002" "False" "3.492" "2" "2" "2" "2" "860" "96.2" "5.27" "5.17" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "55827" "ENSG00000143164" "DCAF6" "A2A295; B4DNB8; hsa:55827; Q58WW2; Q7L8I0; Q8IXH3; Q8TB19" "" "Neddylation" "1" "0" "0.950" "0.962" "0.963" "1.000" "0.978" "1.034" "0.944" "0.866" "0.960" "186.3" "177.1" "179.2" "179.3" "186.3" "182.2" "192.7" "175.9" "161.4" "178.9" "" "" "" "" "" "" "" "" "" "" "174.6" "146.5" "166.3" "138.6" "158.8" "174.1" "176.1" "156.2" "161.4" "172.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5427058765005465503" "False" "High" "IsMasterProtein" "Q7Z6I8" "UPF0461 protein C5orf24 OS=Homo sapiens OX=9606 GN=C5orf24 PE=1 SV=1" "0.002" "False" "3.485" "7" "1" "1" "1" "188" "20.1" "9.85" "2.77" "1" "" "" "" "Pf17724" "134553" "ENSG00000181904" "C5orf24" "D3DQA7; hsa:134553; Q7Z6I8; Q86Y53; Q8N1T9" "" "" "0" "0" "0.941" "1.025" "1.077" "0.971" "0.980" "1.079" "0.878" "0.928" "1.023" "144.9" "136.4" "148.6" "156.1" "140.8" "142.0" "156.4" "127.2" "134.5" "148.3" "" "" "" "" "" "" "" "" "" "" "135.8" "112.9" "138.0" "120.6" "120.0" "135.6" "142.9" "112.9" "134.5" "142.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2064398730154585057" "False" "High" "IsMasterProtein" "Q15061" "WD repeat-containing protein 43 OS=Homo sapiens OX=9606 GN=WDR43 PE=1 SV=3" "0.002" "False" "3.478" "1" "1" "1" "1" "677" "74.8" "5.57" "3.15" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf04003" "23160" "ENSG00000163811" "WDR43" "hsa:23160; Q15061; Q15395; Q92577" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.921" "1.022" "0.863" "1.042" "1.126" "1.132" "1.092" "0.979" "0.965" "50.5" "46.5" "51.6" "43.5" "52.6" "56.8" "57.1" "55.1" "49.4" "48.7" "" "" "" "" "" "" "" "" "" "" "47.3" "38.5" "47.9" "33.7" "44.8" "54.3" "52.2" "48.9" "49.4" "46.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8259676648144024034" "False" "High" "IsMasterProtein" "Q6NT76" "Homeobox-containing protein 1 OS=Homo sapiens OX=9606 GN=HMBOX1 PE=1 SV=1" "0.002" "False" "3.474" "3" "1" "1" "1" "420" "47.2" "6.06" "2.65" "1" "other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf04814" "79618" "ENSG00000147421" "HMBOX1" "A4K385; A8K3R8; B4DHY5; D3DSU0; hsa:79618; Q3Y6P1; Q6NT76; Q96GS5; Q9H701" "miR-222 in exercise-induced cardiac growth" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8458810131294421202" "False" "High" "IsMasterProtein" "Q96IK1" "Biorientation of chromosomes in cell division protein 1 OS=Homo sapiens OX=9606 GN=BOD1 PE=1 SV=2" "0.002" "False" "3.469" "9" "2" "2" "1" "185" "19.2" "6.33" "5.56" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf05205" "91272" "ENSG00000145919" "BOD1" "B4DXH8; hsa:91272; Q96IK1; Q9BTW1" "" "Formation of WDR5-containing histone-modifying complexes" "1" "0" "1.015" "0.941" "1.060" "0.939" "0.930" "0.980" "0.900" "0.844" "0.941" "161.9" "164.4" "152.3" "171.6" "152.1" "150.6" "158.6" "145.8" "136.6" "152.4" "" "" "" "" "" "" "" "" "" "" "151.7" "136.0" "141.4" "132.6" "129.6" "143.9" "144.9" "129.4" "136.6" "146.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4531671785395663771" "False" "High" "IsMasterProtein" "Q5SXM8" "DNL-type zinc finger protein OS=Homo sapiens OX=9606 GN=DNLZ PE=1 SV=1" "0.002" "False" "3.468" "5" "1" "1" "1" "178" "19.2" "9.80" "3.62" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf05180" "728489" "ENSG00000213221" "DNLZ" "B2RUX5; B9EJE1; hsa:728489; Q5SXM8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8959015413367013633" "False" "High" "IsMasterProtein" "Q6P589" "Tumor necrosis factor alpha-induced protein 8-like protein 2 OS=Homo sapiens OX=9606 GN=TNFAIP8L2 PE=1 SV=1" "0.002" "False" "3.464" "6" "1" "2" "1" "184" "20.5" "8.44" "5.38" "1" "stress response;other biological processes" "nucleus;other cytoplasmic organelle;other cell component" "" "Pf05527" "79626" "ENSG00000163154" "TNFAIP8L2" "hsa:79626; Q6I9Y0; Q6P589; Q9H2H7; Q9H5G2" "" "PI Metabolism" "1" "0" "1.354" "1.342" "1.239" "1.254" "1.194" "0.960" "0.870" "0.949" "1.269" "35.3" "47.7" "47.3" "43.7" "44.2" "42.1" "33.9" "30.7" "33.5" "44.8" "" "" "" "" "" "" "" "" "" "" "33.0" "39.5" "43.9" "33.8" "37.7" "40.2" "30.9" "27.2" "33.5" "43.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7752338987200815694" "False" "High" "IsMasterProtein" "Q9NQT4" "Exosome complex component RRP46 OS=Homo sapiens OX=9606 GN=EXOSC5 PE=1 SV=1" "0.002" "False" "3.463" "4" "1" "2" "1" "235" "25.2" "7.59" "6.24" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "56915" "ENSG00000077348" "EXOSC5" "hsa:56915; Q32Q81; Q8NG16; Q96I89; Q9NQT4" "" "ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Major pathway of rRNA processing in the nucleolus and cytosol; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8942814265025091180" "False" "High" "IsMasterProtein" "Q86U28" "Iron-sulfur cluster assembly 2 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=ISCA2 PE=1 SV=2" "0.002" "False" "3.462" "8" "1" "1" "1" "154" "16.5" "5.25" "3.56" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf01521" "122961" "ENSG00000165898" "ISCA2" "A6NFF1; A8K3W3; G3V291; hsa:122961; Q86U28; Q8IYZ0; Q96BB2" "" "Mitochondrial iron-sulfur cluster biogenesis" "1" "0" "1.072" "1.028" "1.240" "1.163" "1.035" "1.098" "1.054" "0.990" "1.087" "110.5" "118.4" "113.5" "136.9" "128.4" "114.4" "121.2" "116.5" "109.4" "120.1" "" "" "" "" "" "" "" "" "" "" "103.5" "98.0" "105.4" "105.8" "109.5" "109.3" "110.8" "103.4" "109.4" "115.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2002470481848011023" "False" "High" "IsMasterProtein" "Q9P032" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 OS=Homo sapiens OX=9606 GN=NDUFAF4 PE=1 SV=1" "0.002" "False" "3.460" "9" "2" "3" "2" "175" "20.3" "8.82" "4.41" "2" "cell organization and biogenesis;stress response;other biological processes" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf06784" "29078" "ENSG00000123545" "NDUFAF4" "B2R4J5; hsa:29078; Q9P032" "" "Complex I biogenesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3256135523585103311" "False" "High" "IsMasterProtein" "Q86XL3" "Ankyrin repeat and LEM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ANKLE2 PE=1 SV=4" "0.002" "False" "3.458" "1" "1" "1" "1" "938" "104.1" "7.09" "2.74" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00023, Pf01693, Pf03020" "23141" "ENSG00000176915" "ANKLE2" "A8KAG3; B3KN97; B3KSF8; hsa:23141; O75176; Q6P6A5; Q86XL3; Q8TAZ9; Q96DH4" "" "RHOG GTPase cycle; RAC2 GTPase cycle; Initiation of Nuclear Envelope (NE) Reformation" "3" "0" "1.001" "1.147" "1.161" "1.269" "0.949" "1.088" "1.132" "1.162" "1.104" "62.5" "62.5" "71.7" "72.5" "79.3" "59.3" "68.0" "70.8" "72.6" "69.0" "" "" "" "" "" "" "" "" "" "" "58.5" "51.7" "66.5" "56.1" "67.6" "56.7" "62.1" "62.8" "72.6" "66.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3077097618423052072" "False" "High" "IsMasterProtein" "Q15032" "R3H domain-containing protein 1 OS=Homo sapiens OX=9606 GN=R3HDM1 PE=1 SV=3" "0.002" "False" "3.458" "1" "1" "1" "1" "1099" "120.6" "8.75" "3.90" "1" "" "" "" "Pf01424, Pf12752" "23518" "ENSG00000048991" "R3HDM1" "A8K1V0; B3KXQ9; E9PBB4; E9PG42; G5E9G8; hsa:23518; Q15032; Q8IW32" "" "" "0" "0" "1.238" "1.110" "1.300" "1.187" "1.022" "1.151" "1.189" "1.045" "1.014" "71.9" "89.0" "79.8" "93.5" "85.3" "73.5" "82.7" "85.5" "75.1" "72.9" "" "" "" "" "" "" "" "" "" "" "67.4" "73.6" "74.1" "72.3" "72.7" "70.2" "75.6" "75.9" "75.1" "70.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8582316469479536789" "False" "High" "IsMasterProtein" "Q92567" "Protein FAM168A OS=Homo sapiens OX=9606 GN=FAM168A PE=1 SV=2" "0.002" "False" "3.457" "4" "1" "1" "1" "244" "26.2" "8.98" "3.63" "1" "other biological processes" "" "" "Pf14944" "23201" "ENSG00000054965" "FAM168A" "A2ICY2; A2ID81; hsa:23201; Q86UG2; Q92567" "" "" "0" "0" "1.313" "1.032" "1.147" "1.035" "1.017" "0.921" "1.017" "1.326" "1.081" "165.4" "217.1" "170.7" "189.8" "171.2" "168.2" "152.4" "168.1" "219.4" "178.8" "" "" "" "" "" "" "" "" "" "" "155.0" "179.6" "158.4" "146.7" "145.9" "160.7" "139.2" "149.3" "219.4" "172.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1870630596764229112" "False" "High" "IsMasterProtein" "Q15643" "Thyroid receptor-interacting protein 11 OS=Homo sapiens OX=9606 GN=TRIP11 PE=1 SV=3" "0.002" "False" "3.456" "1" "2" "2" "2" "1979" "227.4" "5.26" "4.40" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytoskeleton;ER/Golgi" "other molecular function" "" "9321" "ENSG00000100815" "TRIP11" "B2RUT2; hsa:9321; O14689; O15154; O95949; Q15643; Q6MZL5" "" "Intraflagellar transport; Intra-Golgi traffic; Signaling by FLT3 fusion proteins" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3418944464620685589" "False" "High" "IsMasterProtein" "Q9Y478" "5'-AMP-activated protein kinase subunit beta-1 OS=Homo sapiens OX=9606 GN=PRKAB1 PE=1 SV=4" "0.002" "False" "3.451" "7" "1" "1" "1" "270" "30.4" "6.40" "2.64" "1" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf04739, Pf16561" "5564" "ENSG00000111725" "PRKAB1" "hsa:5564; Q9UBV0; Q9UE20; Q9UEX2; Q9Y478; Q9Y6V8" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Leptin and adiponectin; Lipid metabolism pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Pleural mesothelioma" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Activation of AMPK downstream of NMDARs; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy" "25" "0" "0.882" "0.879" "1.032" "0.983" "0.939" "0.969" "0.834" "0.847" "0.941" "61.7" "54.4" "54.2" "63.6" "60.6" "57.9" "59.8" "51.5" "52.2" "58.0" "" "" "" "" "" "" "" "" "" "" "57.8" "45.0" "50.3" "49.2" "51.7" "55.3" "54.6" "45.7" "52.2" "55.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7340038753290804182" "False" "High" "IsMasterProtein" "Q9Y5B9" "FACT complex subunit SPT16 OS=Homo sapiens OX=9606 GN=SUPT16H PE=1 SV=1" "0.002" "False" "3.443" "1" "1" "1" "1" "1047" "119.8" "5.66" "3.23" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00557, Pf08512, Pf08644, Pf14826, Pf21091" "11198" "ENSG00000092201" "SUPT16H" "hsa:11198; Q6GMT8; Q6P2F1; Q6PJM1; Q9NRX0; Q9Y5B9" "" "Regulation of TP53 Activity through Phosphorylation; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "12" "0" "0.926" "1.015" "1.034" "1.072" "0.970" "1.462" "1.542" "1.391" "1.178" "43.0" "39.8" "43.6" "44.5" "46.1" "41.7" "62.9" "66.3" "59.9" "50.7" "" "" "" "" "" "" "" "" "" "" "40.3" "32.9" "40.5" "34.4" "39.3" "39.8" "57.5" "58.9" "59.9" "48.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8826640121646055106" "False" "High" "IsMasterProtein" "P13473" "Lysosome-associated membrane glycoprotein 2 OS=Homo sapiens OX=9606 GN=LAMP2 PE=1 SV=2" "0.002" "False" "3.441" "4" "2" "3" "2" "410" "44.9" "5.63" "8.73" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01299, Pf21222" "3920" "ENSG00000005893" "LAMP2" "A8K4X5; D3DTF0; hsa:3920; P13473; Q16641; Q6Q3G8; Q96J30; Q99534; Q9UD93" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Clock-controlled autophagy in bone metabolism" "Neutrophil degranulation; Platelet degranulation ; Chaperone Mediated Autophagy" "5" "0" "0.997" "0.977" "0.960" "0.901" "0.921" "0.941" "0.946" "0.958" "0.945" "299.2" "298.4" "292.5" "287.2" "269.8" "275.7" "281.7" "283.1" "286.8" "282.8" "" "" "" "" "" "" "" "" "" "" "280.4" "246.9" "271.5" "222.0" "229.9" "263.4" "257.4" "251.4" "286.8" "272.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1396372760161625634" "False" "High" "IsMasterProtein" "Q8N129" "Protein canopy homolog 4 OS=Homo sapiens OX=9606 GN=CNPY4 PE=1 SV=1" "0.002" "False" "3.441" "5" "1" "1" "1" "248" "28.3" "4.64" "3.43" "1" "other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding" "Pf11938" "245812" "ENSG00000166997" "CNPY4" "hsa:245812; Q8N129; Q8WUN9" "" "" "0" "0" "1.218" "1.132" "1.360" "1.221" "1.331" "1.223" "1.207" "1.174" "1.219" "47.1" "57.3" "53.3" "64.0" "57.5" "62.6" "57.5" "56.8" "55.2" "57.4" "" "" "" "" "" "" "" "" "" "" "44.1" "47.4" "49.5" "49.5" "49.0" "59.8" "52.6" "50.5" "55.2" "55.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1233208040052068453" "False" "High" "IsMasterProtein" "Q5T2R2" "All trans-polyprenyl-diphosphate synthase PDSS1 OS=Homo sapiens OX=9606 GN=PDSS1 PE=1 SV=1" "0.002" "False" "3.432" "2" "1" "1" "1" "415" "46.2" "9.00" "3.67" "1" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00348" "23590" "ENSG00000148459" "PDSS1" "hsa:23590; Q53F75; Q5T2R2; Q6P473; Q86WQ8; Q9Y2W5" "" "Ubiquinol biosynthesis" "1" "0" "0.984" "0.985" "1.027" "0.998" "1.023" "1.013" "0.938" "1.045" "0.953" "141.1" "138.8" "138.9" "144.9" "140.8" "144.4" "142.9" "132.3" "147.5" "134.5" "" "" "" "" "" "" "" "" "" "" "132.2" "114.9" "129.0" "112.0" "120.0" "137.9" "130.6" "117.5" "147.5" "129.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8406162996631834722" "False" "High" "IsMasterProtein" "Q7L590" "Protein MCM10 homolog OS=Homo sapiens OX=9606 GN=MCM10 PE=1 SV=2" "0.002" "False" "3.427" "2" "2" "2" "2" "875" "98.1" "8.75" "4.01" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response" "nucleus" "nucleic acid binding activity;other molecular function" "Pf09329, Pf09332" "55388" "ENSG00000065328" "MCM10" "A8K9I6; B7ZKZ8; hsa:55388; Q3MIR3; Q7L590; Q7LD55; Q96GX4; Q96NB6; Q9H0D7; Q9H3P9; Q9P177" "Ciliary landscape; DNA replication" "Activation of ATR in response to replication stress; Activation of the pre-replicative complex" "4" "0" "0.943" "1.193" "0.838" "0.980" "0.987" "0.896" "0.991" "0.808" "0.914" "47.2" "44.5" "56.3" "39.5" "46.2" "46.6" "42.3" "46.7" "38.1" "43.1" "" "" "" "" "" "" "" "" "" "" "44.2" "36.8" "52.2" "30.6" "39.4" "44.5" "38.6" "41.5" "38.1" "41.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6473886272279589766" "False" "High" "IsMasterProtein" "Q9Y2X9" "Zinc finger protein 281 OS=Homo sapiens OX=9606 GN=ZNF281 PE=1 SV=1" "0.002" "False" "3.426" "1" "1" "1" "1" "895" "96.9" "8.48" "3.26" "1" "developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "23528" "ENSG00000162702" "ZNF281" "A6NF48; B3KMX2; hsa:23528; Q5RKW5; Q9NY92; Q9Y2X9" "Mesodermal commitment pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3780861066822238698" "False" "High" "IsMasterProtein" "Q9H788" "SH2 domain-containing protein 4A OS=Homo sapiens OX=9606 GN=SH2D4A PE=1 SV=1" "0.002" "False" "3.426" "2" "1" "1" "1" "454" "52.7" "8.06" "3.73" "1" "" "cytosol;other cell component" "other molecular function" "Pf00017" "63898" "ENSG00000104611" "SH2D4A" "B4DDR1; hsa:63898; Q5XKC1; Q6NXE9; Q86YM2; Q96C88; Q9H788; Q9H7F7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5882151393090730100" "False" "High" "IsMasterProtein" "Q8TA86" "Retinitis pigmentosa 9 protein OS=Homo sapiens OX=9606 GN=RP9 PE=1 SV=2" "0.002" "False" "3.410" "4" "1" "1" "1" "221" "26.1" "9.79" "3.45" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "" "6100" "ENSG00000164610" "RP9" "hsa:6100; Q8TA86" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3159799509992601123" "False" "High" "IsMasterProtein" "Q96FK6" "WD repeat-containing protein 89 OS=Homo sapiens OX=9606 GN=WDR89 PE=1 SV=1" "0.002" "False" "3.409" "3" "1" "1" "1" "387" "43.2" "6.13" "2.83" "1" "developmental processes" "" "" "Pf00400" "112840" "ENSG00000140006" "WDR89" "hsa:112840; Q96FK6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-175071030841702515" "False" "High" "IsMasterProtein" "Q96N06" "Spermatogenesis-associated protein 33 OS=Homo sapiens OX=9606 GN=SPATA33 PE=1 SV=1" "0.002" "False" "3.396" "7" "1" "1" "1" "139" "15.5" "9.22" "2.84" "1" "cell organization and biogenesis;other metabolic processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "" "Pf15382" "124045" "ENSG00000167523" "SPATA33" "A8WFL2; B4DZN8; hsa:124045; Q96N06" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3120640487531832187" "False" "High" "IsMasterProtein" "Q9BTT4" "Mediator of RNA polymerase II transcription subunit 10 OS=Homo sapiens OX=9606 GN=MED10 PE=1 SV=1" "0.002" "False" "3.395" "7" "1" "1" "1" "135" "15.7" "6.19" "3.46" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09748" "84246" "ENSG00000133398; ENSG00000291745" "MED10" "C6G491; hsa:84246; Q9BTT4" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6890831805190457766" "False" "High" "IsMasterProtein" "Q9BV73" "Centrosome-associated protein CEP250 OS=Homo sapiens OX=9606 GN=CEP250 PE=1 SV=2" "0.002" "False" "3.390" "1" "1" "1" "1" "2442" "281.0" "5.02" "1.73" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf15035" "11190" "ENSG00000126001" "CEP250" "E1P5Q3; hsa:11190; O14812; O60588; Q9BV73; Q9H450" "Mesodermal commitment pathway" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7857168411920132290" "False" "High" "IsMasterProtein" "Q9Y5B8" "Nucleoside diphosphate kinase homolog 7 OS=Homo sapiens OX=9606 GN=NME7 PE=1 SV=1" "0.002" "False" "3.390" "2" "1" "2" "1" "376" "42.5" "6.47" "5.55" "1" "other metabolic processes" "cytosol;cytoskeleton" "kinase activity;other molecular function" "Pf00334" "29922" "ENSG00000143156" "NME7" "A8K3T6; A8MY09; B3KSW9; hsa:29922; Q5TGZ4; Q9Y5B8" "Pyrimidine metabolism; Ciliopathies" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8230923864296422238" "False" "High" "IsMasterProtein" "Q9Y303" "N-acetylglucosamine-6-phosphate deacetylase OS=Homo sapiens OX=9606 GN=AMDHD2 PE=1 SV=2" "0.002" "False" "3.389" "5" "2" "2" "2" "409" "43.7" "6.70" "4.98" "2" "other metabolic processes" "cytosol" "other molecular function" "Pf01979" "51005" "ENSG00000162066" "AMDHD2" "B4DL77; hsa:51005; Q8WV54; Q9Y303" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "0" "1.144" "0.978" "1.112" "1.089" "0.988" "0.936" "0.833" "0.988" "0.941" "156.4" "178.9" "153.1" "173.9" "170.4" "154.6" "146.5" "130.3" "154.5" "147.2" "" "" "" "" "" "" "" "" "" "" "146.6" "148.1" "142.1" "134.5" "145.2" "147.7" "133.9" "115.7" "154.5" "141.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8514110242710764604" "False" "High" "IsMasterProtein" "P48553" "Trafficking protein particle complex subunit 10 OS=Homo sapiens OX=9606 GN=TRAPPC10 PE=1 SV=2" "0.002" "False" "3.387" "1" "1" "1" "1" "1259" "142.1" "6.04" "3.28" "1" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf12584" "7109" "ENSG00000160218" "TRAPPC10" "hsa:7109; P48553; Q3MIR2; Q86SI7; Q9UMD4; Q9Y4L3" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "1.047" "1.003" "1.037" "1.074" "1.018" "1.048" "0.915" "1.036" "1.032" "202.4" "211.9" "203.0" "209.9" "217.5" "206.2" "212.0" "185.3" "209.7" "208.9" "" "" "" "" "" "" "" "" "" "" "189.7" "175.3" "188.5" "162.3" "185.4" "197.0" "193.8" "164.5" "209.7" "201.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "980911746470048228" "False" "High" "IsMasterProtein" "P40337" "von Hippel-Lindau disease tumor suppressor OS=Homo sapiens OX=9606 GN=VHL PE=1 SV=2" "0.002" "False" "3.381" "7" "1" "1" "1" "213" "24.1" "4.73" "4.03" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01847, Pf17211" "7428" "ENSG00000134086" "VHL" "B2RE45; hsa:7428; P40337; Q13599; Q6PDA9" "Amplification and expansion of oncogenic pathways as metastatic traits; Clear cell renal cell carcinoma pathways; Type 2 papillary renal cell carcinoma; Orexin receptor pathway; Warburg effect modulated by deubiquitinating enzymes and their substrates; HDAC6 interactions in the central nervous system" "Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation; SUMOylation of ubiquitinylation proteins; RHOBTB3 ATPase cycle; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome" "13" "0" "1.016" "0.935" "1.027" "0.948" "0.987" "0.926" "0.980" "1.004" "1.036" "179.8" "182.6" "168.1" "184.5" "170.4" "177.4" "166.5" "176.2" "180.5" "186.2" "" "" "" "" "" "" "" "" "" "" "168.4" "151.1" "156.0" "142.7" "145.3" "169.5" "152.1" "156.4" "180.5" "179.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3561433586626158640" "False" "High" "IsMasterProtein" "Q7Z5L2" "Coiled-coil domain-containing protein R3HCC1L OS=Homo sapiens OX=9606 GN=R3HCC1L PE=1 SV=3" "0.002" "False" "3.380" "1" "1" "1" "1" "792" "87.8" "5.16" "3.21" "1" "" "" "" "" "27291" "ENSG00000166024" "R3HCC1L" "hsa:27291; O60598; Q5W0B4; Q5W0B5; Q7Z5L2; Q86VT9; Q8N9H0" "" "" "0" "0" "1.023" "1.078" "1.212" "1.084" "1.049" "1.041" "1.215" "1.010" "1.165" "96.2" "98.4" "103.7" "116.5" "104.3" "100.9" "100.1" "116.8" "97.1" "112.0" "" "" "" "" "" "" "" "" "" "" "90.1" "81.4" "96.3" "90.1" "88.9" "96.4" "91.5" "103.7" "97.1" "107.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2559910864719892942" "False" "High" "IsMasterProtein" "Q9NU19" "TBC1 domain family member 22B OS=Homo sapiens OX=9606 GN=TBC1D22B PE=1 SV=3" "0.002" "False" "3.379" "3" "2" "2" "1" "505" "59.0" "7.39" "4.07" "2" "" "" "enzyme regulator activity;other molecular function" "Pf00566" "55633" "ENSG00000065491" "TBC1D22B" "A8KA28; hsa:55633; Q32MQ8; Q5VUK9; Q6P4C3; Q7Z6P7; Q9BPV6; Q9BUT5; Q9NU19; Q9NXB6" "" "" "0" "0" "1.068" "1.097" "1.161" "1.204" "1.073" "1.059" "0.986" "1.085" "1.046" "109.4" "116.9" "120.1" "127.1" "131.8" "117.4" "115.9" "107.9" "118.8" "114.4" "" "" "" "" "" "" "" "" "" "" "102.5" "96.7" "111.5" "98.2" "112.3" "112.2" "105.9" "95.8" "118.8" "110.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8213215215106064220" "False" "High" "IsMasterProtein" "Q8WZ82" "Esterase OVCA2 OS=Homo sapiens OX=9606 GN=OVCA2 PE=1 SV=1" "0.002" "False" "3.364" "7" "1" "1" "1" "227" "24.4" "6.89" "3.18" "1" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf03959" "124641" "ENSG00000262664" "OVCA2" "hsa:124641; Q86XN3; Q8IW87; Q8WZ82; Q9UCX9" "" "" "0" "0" "1.315" "1.085" "1.201" "1.187" "1.185" "1.127" "1.176" "1.198" "1.098" "56.1" "73.8" "60.9" "67.4" "66.6" "66.5" "63.3" "66.0" "67.3" "61.6" "" "" "" "" "" "" "" "" "" "" "52.6" "61.1" "56.5" "52.1" "56.8" "63.6" "57.8" "58.6" "67.3" "59.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7550223946587707614" "False" "High" "IsMasterProtein" "Q13232" "Nucleoside diphosphate kinase 3 OS=Homo sapiens OX=9606 GN=NME3 PE=1 SV=2" "0.002" "False" "3.364" "6" "1" "1" "1" "169" "19.0" "7.84" "3.55" "1" "other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00334" "4832" "ENSG00000103024" "NME3" "hsa:4832; Q13232; Q9BWH4" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1016656761563188351" "False" "High" "IsMasterProtein" "O15127" "Secretory carrier-associated membrane protein 2 OS=Homo sapiens OX=9606 GN=SCAMP2 PE=1 SV=2" "0.002" "False" "3.363" "4" "1" "1" "1" "329" "36.6" "6.10" "3.19" "1" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04144" "10066" "ENSG00000140497" "SCAMP2" "B2RDF0; hsa:10066; O15127; Q9BQE8" "Serotonin transporter activity; Monoamine transport" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9120565565592818035" "False" "High" "IsMasterProtein" "P23443" "Ribosomal protein S6 kinase beta-1 OS=Homo sapiens OX=9606 GN=RPS6KB1 PE=1 SV=2" "0.002" "False" "3.363" "5" "2" "2" "2" "525" "59.1" "6.65" "6.03" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433" "6198" "ENSG00000108443" "RPS6KB1" "B2R779; B4DLT4; B4DTG1; E7ESB8; F6UYM1; hsa:6198; P23443; Q7Z721" "IL-5 signaling pathway; AMP-activated protein kinase signaling; Target of rapamycin signaling; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Kit receptor signaling pathway; IL6 signaling pathway; BDNF-TrkB signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PI3K-Akt signaling pathway; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Thermogenesis; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; GDNF signaling; G13 signaling pathway; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways; ErbB signaling pathway" "mTORC1-mediated signalling" "42" "0" "0.919" "1.044" "1.070" "1.086" "1.011" "1.002" "0.934" "0.936" "1.066" "687.0" "631.6" "717.2" "735.2" "746.4" "694.9" "688.6" "641.6" "642.8" "732.2" "" "" "" "" "" "" "" "" "" "" "643.7" "522.6" "665.8" "568.3" "636.2" "663.9" "629.2" "569.7" "642.8" "705.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2544535754369701430" "False" "High" "IsMasterProtein" "Q8IYB9" "Zinc finger protein 595 OS=Homo sapiens OX=9606 GN=ZNF595 PE=1 SV=2" "0.002" "False" "3.361" "2" "2" "2" "1" "648" "74.3" "9.11" "4.05" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "152687" "ENSG00000272602" "ZNF595" "hsa:152687; Q7Z3I0; Q8IYB9" "" "Generic Transcription Pathway" "1" "1" "0.913" "0.873" "0.798" "0.797" "0.786" "0.644" "0.622" "0.616" "0.801" "218.4" "199.4" "190.6" "174.3" "174.1" "171.6" "140.6" "135.8" "134.5" "174.9" "" "" "" "" "" "" "" "" "" "" "204.6" "165.0" "177.0" "134.8" "148.4" "164.0" "128.4" "120.5" "134.5" "168.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4261642457935236614" "False" "High" "IsMasterProtein" "Q9NS73" "MAP3K12-binding inhibitory protein 1 OS=Homo sapiens OX=9606 GN=MBIP PE=1 SV=2" "0.002" "False" "3.360" "3" "1" "1" "1" "344" "39.3" "7.24" "3.36" "1" "other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "" "51562" "ENSG00000151332" "MBIP" "hsa:51562; Q86TZ2; Q96AS5; Q9BS93; Q9NS73; Q9NZE1" "" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "2" "0" "0.893" "0.986" "0.926" "1.078" "1.373" "1.495" "0.956" "1.310" "1.121" "70.8" "63.2" "69.8" "65.5" "76.3" "97.2" "105.8" "67.6" "92.7" "79.3" "" "" "" "" "" "" "" "" "" "" "66.3" "52.3" "64.8" "50.6" "65.0" "92.8" "96.7" "60.0" "92.7" "76.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3480687027944615342" "False" "High" "IsMasterProtein" "Q8NHG8" "E3 ubiquitin-protein ligase ZNRF2 OS=Homo sapiens OX=9606 GN=ZNRF2 PE=1 SV=1" "0.002" "False" "3.347" "5" "1" "2" "1" "242" "24.1" "7.09" "8.57" "1" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13639" "223082" "ENSG00000180233" "ZNRF2" "Q8NHG8" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3754382258737944185" "False" "High" "IsMasterProtein" "Q9Y546" "Leucine-rich repeat-containing protein 42 OS=Homo sapiens OX=9606 GN=LRRC42 PE=1 SV=1" "0.002" "False" "3.343" "2" "1" "1" "1" "428" "48.5" "7.46" "2.65" "1" "" "" "" "Pf13516" "115353" "ENSG00000116212" "LRRC42" "D3DQ46; hsa:115353; Q8N2Q8; Q9Y546" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7358816721095253200" "False" "High" "IsMasterProtein" "Q5JTY5" "Zinc-regulated GTPase metalloprotein activator 1C OS=Homo sapiens OX=9606 GN=ZNG1C PE=1 SV=1" "0.002" "False" "3.339" "3" "1" "1" "1" "395" "44.0" "4.87" "2.58" "1" "" "nucleus;other cell component" "other molecular function" "Pf02492, Pf07683" "445571" "ENSG00000196873" "ZNG1C" "B4DNG9; hsa:445571; Q5JTY5; Q6VB91" "" "" "0" "0" "1.066" "1.002" "1.312" "1.124" "0.973" "1.024" "0.980" "1.037" "0.893" "85.6" "91.2" "85.8" "112.3" "96.2" "83.3" "87.7" "83.9" "88.8" "76.4" "" "" "" "" "" "" "" "" "" "" "80.2" "75.5" "79.6" "86.8" "82.0" "79.6" "80.1" "74.5" "88.8" "73.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5094806735738830032" "False" "High" "IsMasterProtein" "O75151" "Lysine-specific demethylase PHF2 OS=Homo sapiens OX=9606 GN=PHF2 PE=1 SV=4" "0.002" "False" "3.329" "1" "1" "1" "1" "1096" "120.7" "9.17" "3.98" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00628, Pf02373, Pf17811" "5253" "ENSG00000197724" "PHF2" "hsa:5253; O75151; Q4VXG0; Q8N3K2; Q9Y6N4" "" "HDMs demethylate histones" "1" "0" "0.915" "0.929" "1.218" "1.270" "1.262" "1.868" "1.824" "1.936" "1.266" "64.4" "59.0" "59.8" "78.5" "81.8" "81.3" "120.3" "117.5" "124.8" "81.6" "" "" "" "" "" "" "" "" "" "" "60.4" "48.8" "55.6" "60.7" "69.7" "77.7" "110.0" "104.4" "124.8" "78.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2564730176707544032" "False" "High" "IsMasterProtein" "O95479" "GDH/6PGL endoplasmic bifunctional protein OS=Homo sapiens OX=9606 GN=H6PD PE=1 SV=2" "0.002" "False" "3.327" "3" "2" "3" "2" "791" "88.8" "7.30" "5.33" "2" "other metabolic processes;other biological processes" "ER/Golgi" "other molecular function" "Pf00479, Pf01182, Pf02781" "9563" "ENSG00000049239" "H6PD" "hsa:9563; O95479; Q4TT33; Q66I35; Q68DT3; R4GMU1" "Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism" "" "1" "0" "0.889" "0.865" "0.838" "0.864" "0.861" "0.814" "0.812" "0.734" "0.849" "411.0" "365.3" "355.4" "344.4" "355.3" "354.0" "334.4" "333.7" "301.7" "348.8" "" "" "" "" "" "" "" "" "" "" "385.1" "302.3" "329.9" "266.3" "302.8" "338.2" "305.6" "296.2" "301.7" "335.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-615574855873468037" "False" "High" "IsMasterProtein" "O75928" "E3 SUMO-protein ligase PIAS2 OS=Homo sapiens OX=9606 GN=PIAS2 PE=1 SV=3" "0.002" "False" "3.326" "3" "1" "1" "1" "621" "68.2" "7.52" "2.41" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02891, Pf14324" "9063" "ENSG00000078043" "PIAS2" "O75927; O75928; Q96BT5; Q96KE3" "Androgen receptor signaling pathway; TGF-beta signaling pathway" "Activation of anterior HOX genes in hindbrain development during early embryogenesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3813921513967771332" "False" "High" "IsMasterProtein" "P51825" "AF4/FMR2 family member 1 OS=Homo sapiens OX=9606 GN=AFF1 PE=1 SV=1" "0.002" "False" "3.324" "1" "2" "2" "2" "1210" "131.3" "9.20" "3.90" "2" "other biological processes" "nucleus" "" "Pf05110, Pf18875, Pf18876" "4299" "ENSG00000172493" "AFF1" "B4DTU1; E9PBM3; hsa:4299; P51825" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9052847319979577179" "False" "High" "IsMasterProtein" "Q86XN8" "RNA-binding protein MEX3D OS=Homo sapiens OX=9606 GN=MEX3D PE=1 SV=3" "0.002" "False" "3.321" "3" "2" "2" "1" "651" "64.8" "5.35" "1.70" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf13920" "399664" "ENSG00000181588" "MEX3D" "A0PJL8; A1L023; E9PAL6; hsa:399664; Q71M49; Q86XN8" "" "" "0" "0" "0.958" "0.969" "1.004" "0.929" "0.882" "0.701" "0.833" "0.649" "0.859" "47.9" "45.9" "46.5" "48.1" "44.5" "42.3" "33.6" "39.9" "31.1" "41.2" "" "" "" "" "" "" "" "" "" "" "44.9" "38.0" "43.1" "37.2" "38.0" "40.4" "30.7" "35.4" "31.1" "39.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7441376780111574138" "False" "High" "IsMasterProtein" "Q96BS2" "Calcineurin B homologous protein 3 OS=Homo sapiens OX=9606 GN=TESC PE=1 SV=3" "0.002" "False" "3.319" "7" "1" "1" "1" "214" "24.7" "4.93" "3.30" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13405" "54997" "ENSG00000088992" "TESC" "F5H1Y5; hsa:54997; Q96BS2; Q9NWT9" "" "" "0" "0" "1.044" "0.959" "1.187" "1.272" "1.175" "1.191" "1.077" "1.261" "1.156" "62.8" "65.6" "60.3" "74.6" "79.9" "73.8" "74.8" "67.6" "79.2" "72.6" "" "" "" "" "" "" "" "" "" "" "58.9" "54.3" "55.9" "57.7" "68.1" "70.5" "68.4" "60.1" "79.2" "69.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6343955122227256194" "False" "High" "IsMasterProtein" "Q01831" "DNA repair protein complementing XP-C cells OS=Homo sapiens OX=9606 GN=XPC PE=1 SV=4" "0.002" "False" "3.318" "2" "2" "2" "2" "940" "105.9" "8.90" "4.40" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03835, Pf10403, Pf10404, Pf10405" "7508" "ENSG00000154767" "XPC" "B4DIP3; E9PB96; E9PH69; hsa:7508; Q01831; Q53GT7; Q96AX0" "Male infertility; Nucleotide excision repair; DNA repair pathways, full network; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum" "SUMOylation of DNA damage response and repair proteins; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4883564284683211027" "False" "High" "IsMasterProtein" "P15863" "Paired box protein Pax-1 OS=Homo sapiens OX=9606 GN=PAX1 PE=1 SV=4" "0.002" "False" "3.317" "4" "2" "2" "1" "534" "55.5" "9.86" "4.99" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00292" "5075" "ENSG00000125813" "PAX1" "B4E0D6; hsa:5075; P15863; Q642X9; Q6NTC0; Q9Y558" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9023891521044108187" "False" "High" "IsMasterProtein" "Q96BX8" "MOB kinase activator 3A OS=Homo sapiens OX=9606 GN=MOB3A PE=1 SV=1" "0.002" "False" "3.316" "8" "2" "2" "2" "217" "25.4" "8.63" "3.09" "2" "signal transduction;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03637" "126308" "ENSG00000172081" "MOB3A" "B3KTF1; hsa:126308; O75249; Q8TF69; Q96BX8" "" "" "0" "0" "0.906" "0.966" "0.976" "1.051" "1.020" "0.942" "0.965" "1.018" "1.070" "322.4" "292.1" "311.3" "314.6" "338.9" "328.9" "303.8" "311.2" "328.3" "344.9" "" "" "" "" "" "" "" "" "" "" "302.0" "241.7" "289.0" "243.2" "288.9" "314.2" "277.6" "276.3" "328.3" "332.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5094708502747754814" "False" "High" "IsMasterProtein" "P61313" "Large ribosomal subunit protein eL15 OS=Homo sapiens OX=9606 GN=RPL15 PE=1 SV=2" "0.002" "False" "3.315" "4" "1" "1" "1" "204" "24.1" "11.62" "2.62" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00827" "6138" "ENSG00000174748" "RPL15" "hsa:6138; P39030; P41051; P61313; Q5U0C0; Q642I1; Q6IPX6; Q8WYP2; Q96C44; Q9H2E5" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8364917298053465575" "False" "High" "IsMasterProtein" "Q9UQ88" "Cyclin-dependent kinase 11A OS=Homo sapiens OX=9606 GN=CDK11A PE=1 SV=4" "0.002" "False" "3.306" "2" "2" "2" "2" "783" "91.3" "5.36" "4.64" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "728642" "ENSG00000008128" "CDK11A" "hsa:728642; O95227; O95228; O96012; Q12821; Q12853; Q12854; Q2TAJ0; Q5QPR0; Q5QPR1; Q5QPR2; Q9UBC4; Q9UBI3; Q9UEI1; Q9UEI2; Q9UP53; Q9UP54; Q9UP55; Q9UP56; Q9UQ86; Q9UQ87; Q9UQ88; Q9UQ89" "1p36 copy number variation syndrome" "Recruitment of mitotic centrosome proteins and complexes" "2" "0" "0.993" "0.957" "0.942" "0.934" "0.969" "1.032" "0.996" "0.993" "1.131" "104.1" "103.4" "99.6" "98.1" "97.2" "100.8" "107.3" "103.6" "103.3" "117.7" "" "" "" "" "" "" "" "" "" "" "97.5" "85.5" "92.4" "75.8" "82.9" "96.3" "98.1" "92.0" "103.3" "113.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1343796778633741074" "False" "High" "IsMasterProtein" "Q9NPI1" "Bromodomain-containing protein 7 OS=Homo sapiens OX=9606 GN=BRD7 PE=1 SV=1" "0.002" "False" "3.291" "1" "1" "1" "1" "651" "74.1" "6.39" "3.07" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf12024" "29117" "ENSG00000166164" "BRD7" "hsa:29117; Q4VC09; Q8N2L9; Q96KA4; Q9BV48; Q9NPI1; Q9UH59" "" "Regulation of TP53 Activity through Acetylation" "1" "0" "0.951" "1.063" "0.924" "0.995" "0.995" "1.080" "0.990" "1.020" "0.986" "91.7" "87.2" "97.5" "84.8" "91.3" "91.3" "99.1" "90.8" "93.6" "90.5" "" "" "" "" "" "" "" "" "" "" "86.0" "72.2" "90.5" "65.5" "77.8" "87.2" "90.5" "80.6" "93.6" "87.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7842122085258800044" "False" "High" "IsMasterProtein" "Q9BVM4" "Gamma-glutamylaminecyclotransferase OS=Homo sapiens OX=9606 GN=GGACT PE=1 SV=2" "0.002" "False" "3.291" "7" "1" "1" "1" "153" "17.3" "6.87" "2.82" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf06094" "87769" "ENSG00000134864" "GGACT" "B3KTN1; hsa:87769; Q9BT41; Q9BVM4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4689562730932566719" "False" "High" "IsMasterProtein" "Q9Y620" "DNA repair and recombination protein RAD54B OS=Homo sapiens OX=9606 GN=RAD54B PE=1 SV=1" "0.002" "False" "3.290" "1" "1" "1" "1" "910" "102.9" "8.12" "3.29" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "25788" "ENSG00000197275" "RAD54B" "F6WBS8; hsa:25788; Q9Y620" "Homologous recombination; DNA repair pathways, full network" "" "2" "0" "0.999" "1.034" "1.207" "1.060" "1.030" "0.988" "0.998" "0.914" "1.064" "89.8" "89.7" "92.9" "108.4" "95.2" "92.5" "88.7" "89.6" "82.1" "95.6" "" "" "" "" "" "" "" "" "" "" "84.2" "74.2" "86.2" "83.8" "81.1" "88.4" "81.1" "79.6" "82.1" "92.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3081581238024006114" "False" "High" "IsMasterProtein" "Q96S99" "Pleckstrin homology domain-containing family F member 1 OS=Homo sapiens OX=9606 GN=PLEKHF1 PE=1 SV=3" "0.002" "False" "3.285" "4" "1" "1" "1" "279" "31.2" "8.24" "3.49" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00169, Pf01363" "79156" "ENSG00000166289" "PLEKHF1" "hsa:79156; Q96K11; Q96S99; Q9BUB9" "" "" "0" "0" "1.095" "1.216" "1.260" "1.134" "1.117" "1.137" "0.964" "1.050" "1.154" "95.8" "105.0" "116.5" "120.7" "108.7" "107.1" "109.0" "92.4" "100.7" "110.6" "" "" "" "" "" "" "" "" "" "" "89.8" "86.9" "108.2" "93.3" "92.7" "102.3" "99.6" "82.1" "100.7" "106.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1889758281858521724" "False" "High" "IsMasterProtein" "Q53HC5" "Kelch-like protein 26 OS=Homo sapiens OX=9606 GN=KLHL26 PE=1 SV=2" "0.002" "False" "3.283" "3" "1" "1" "1" "615" "68.1" "6.48" "2.93" "1" "" "" "" "Pf00651, Pf01344, Pf07707, Pf13964" "55295" "ENSG00000167487" "KLHL26" "hsa:55295; Q53HC5; Q8TAP0; Q9NUX3" "" "" "0" "0" "1.024" "0.811" "1.164" "1.009" "0.908" "1.103" "1.018" "0.815" "0.853" "45.4" "46.5" "36.8" "52.8" "45.8" "41.2" "50.0" "46.2" "37.0" "38.7" "" "" "" "" "" "" "" "" "" "" "42.5" "38.4" "34.2" "40.8" "39.0" "39.4" "45.7" "41.0" "37.0" "37.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4040325489223208351" "False" "High" "IsMasterProtein" "O75486" "Transcription initiation protein SPT3 homolog OS=Homo sapiens OX=9606 GN=SUPT3H PE=1 SV=3" "0.002" "False" "3.279" "3" "1" "1" "1" "317" "35.8" "6.87" "2.23" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02269" "8464" "ENSG00000196284" "SUPT3H" "A6NKG9; B2R9Q5; hsa:8464; O75486; O76066; Q5TAV9; Q86VN7" "" "HATs acetylate histones" "1" "0" "1.084" "1.116" "1.261" "1.204" "1.038" "1.255" "1.275" "1.051" "1.061" "64.2" "69.6" "71.6" "81.0" "77.3" "66.6" "80.6" "81.8" "67.5" "68.1" "" "" "" "" "" "" "" "" "" "" "60.1" "57.6" "66.5" "62.6" "65.9" "63.6" "73.6" "72.7" "67.5" "65.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7524617474399668793" "False" "High" "IsMasterProtein" "Q6DD88" "Atlastin-3 OS=Homo sapiens OX=9606 GN=ATL3 PE=1 SV=1" "0.002" "False" "3.276" "3" "2" "2" "2" "541" "60.5" "5.66" "4.96" "2" "cell organization and biogenesis;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf02263, Pf02841" "25923" "ENSG00000184743" "ATL3" "hsa:25923; Q6DD88; Q8N7W5; Q9H8Q5; Q9UFL1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5267554590826270529" "False" "High" "IsMasterProtein" "P62380" "TATA box-binding protein-like 1 OS=Homo sapiens OX=9606 GN=TBPL1 PE=1 SV=1" "0.002" "False" "3.271" "6" "1" "1" "1" "186" "20.9" "9.54" "3.20" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00352" "9519" "ENSG00000028839" "TBPL1" "A8K8F5; hsa:9519; O95753; P62380; Q9BWD5; Q9Z2Z0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6159881748144421319" "False" "High" "IsMasterProtein" "Q9NQC7" "Ubiquitin carboxyl-terminal hydrolase CYLD OS=Homo sapiens OX=9606 GN=CYLD PE=1 SV=1" "0.002" "False" "3.246" "1" "1" "1" "1" "956" "107.2" "5.59" "2.69" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00443, Pf01302, Pf16607" "1540" "ENSG00000083799" "CYLD" "hsa:1540; O94934; Q7L3N6; Q96EH0; Q9NQC7; Q9NZX9" "Novel intracellular components of RIG-I-like receptor pathway; Cytosolic DNA-sensing pathway" "Ub-specific processing proteases; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling; NOD1/2 Signaling Pathway; Negative regulators of DDX58/IFIH1 signaling" "8" "0" "1.110" "1.059" "1.093" "1.145" "1.093" "1.176" "0.964" "1.029" "1.159" "81.8" "90.8" "86.6" "89.3" "93.6" "89.4" "96.2" "78.8" "84.2" "94.8" "" "" "" "" "" "" "" "" "" "" "76.6" "75.1" "80.4" "69.1" "79.8" "85.4" "87.9" "69.9" "84.2" "91.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5030873736405490960" "False" "High" "IsMasterProtein" "Q92686" "Neurogranin OS=Homo sapiens OX=9606 GN=NRGN PE=1 SV=1" "0.002" "False" "3.245" "13" "1" "2" "1" "78" "7.6" "7.87" "4.86" "1" "developmental processes;signal transduction" "cytosol" "other molecular function" "Pf00612" "4900" "ENSG00000154146" "NRGN" "hsa:4900; Q92686" "" "Long-term potentiation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8032789585989089755" "False" "High" "IsMasterProtein" "Q9BYV9" "Transcription regulator protein BACH2 OS=Homo sapiens OX=9606 GN=BACH2 PE=1 SV=1" "0.002" "False" "3.238" "2" "2" "2" "2" "841" "92.5" "5.10" "5.54" "2" "transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651, Pf03131" "60468" "ENSG00000112182" "BACH2" "E1P518; hsa:60468; Q59H70; Q5T793; Q9BYV9; Q9NTS5" "Extrafollicular and follicular B cell activation by SARS-CoV-2" "" "1" "0" "1.027" "1.047" "1.056" "1.057" "0.975" "1.006" "1.017" "0.952" "1.013" "288.0" "295.7" "301.6" "304.2" "304.6" "280.9" "289.9" "292.9" "274.3" "291.9" "" "" "" "" "" "" "" "" "" "" "269.9" "244.7" "280.0" "235.2" "259.6" "268.4" "264.9" "260.1" "274.3" "281.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5308082143838358470" "False" "High" "IsMasterProtein" "P42766" "Large ribosomal subunit protein uL29 OS=Homo sapiens OX=9606 GN=RPL35 PE=1 SV=2" "0.002" "False" "3.230" "11" "2" "2" "2" "123" "14.5" "11.05" "5.77" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00831" "11224" "ENSG00000136942" "RPL35" "A8K4V7; hsa:11224; P42766; Q4VBY5; Q5JTN5; Q6IBC7; Q96QJ7; Q9BYF4" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.035" "0.967" "1.047" "1.059" "1.035" "1.116" "0.919" "1.002" "0.950" "287.3" "297.3" "277.8" "300.9" "304.3" "297.4" "320.7" "264.1" "287.8" "272.9" "" "" "" "" "" "" "" "" "" "" "269.2" "246.0" "257.9" "232.6" "259.4" "284.2" "293.0" "234.5" "287.8" "262.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3991295495987680044" "False" "High" "IsMasterProtein" "Q15544" "Transcription initiation factor TFIID subunit 11 OS=Homo sapiens OX=9606 GN=TAF11 PE=1 SV=1" "0.002" "False" "3.229" "5" "1" "1" "1" "211" "23.3" "4.88" "2.66" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf04719" "6882" "ENSG00000064995" "TAF11" "B2R8R3; B4DY18; hsa:6882; Q15544; Q9UHS0" "" "Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4311553193835580120" "False" "High" "IsMasterProtein" "P56556" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 OS=Homo sapiens OX=9606 GN=NDUFA6 PE=1 SV=4" "0.002" "False" "3.225" "6" "1" "1" "1" "128" "15.1" "9.98" "3.03" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport" "other membranes;mitochondrion" "transporter activity" "Pf13233" "4700" "ENSG00000184983; ENSG00000272765; ENSG00000273397; ENSG00000277365; ENSG00000281013" "NDUFA6" "B2RE54; hsa:4700; O43675; P56556; Q6FGW0; Q6IBT8; Q6IC39" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5184955907910039007" "False" "High" "IsMasterProtein" "Q13325" "Interferon-induced protein with tetratricopeptide repeats 5 OS=Homo sapiens OX=9606 GN=IFIT5 PE=1 SV=1" "0.002" "False" "3.222" "3" "2" "2" "2" "482" "55.8" "7.40" "5.78" "2" "stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "nucleic acid binding activity" "Pf13181, Pf13374, Pf13424" "24138" "ENSG00000152778" "IFIT5" "B2R5X9; B4DDV1; hsa:24138; Q13325; Q5T7I9; Q6IAX3" "" "Interferon alpha/beta signaling" "1" "0" "1.083" "1.141" "1.200" "1.014" "1.022" "1.153" "1.127" "1.073" "1.072" "80.2" "86.8" "91.5" "96.2" "81.3" "82.0" "92.4" "90.3" "86.0" "86.0" "" "" "" "" "" "" "" "" "" "" "75.1" "71.9" "84.9" "74.4" "69.3" "78.3" "84.5" "80.2" "86.0" "82.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "107248944887719922" "False" "High" "IsMasterProtein" "Q6VN20" "Ran-binding protein 10 OS=Homo sapiens OX=9606 GN=RANBP10 PE=1 SV=1" "0.002" "False" "3.221" "2" "1" "1" "1" "620" "67.2" "6.77" "2.40" "1" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf00622, Pf08513, Pf10607" "57610" "ENSG00000141084" "RANBP10" "A4FTY2; B4DID0; B4DQH9; E7EW27; hsa:57610; Q6VN20; Q9P264" "Ciliary landscape" "MET activates RAS signaling" "2" "0" "0.910" "1.021" "0.992" "1.068" "1.073" "0.933" "0.975" "0.921" "1.046" "97.0" "88.2" "99.0" "96.2" "103.5" "104.1" "90.4" "94.5" "89.3" "101.5" "" "" "" "" "" "" "" "" "" "" "90.8" "73.0" "91.9" "74.3" "88.2" "99.4" "82.6" "83.9" "89.3" "97.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5530400762788936201" "False" "High" "IsMasterProtein" "O43299" "AP-5 complex subunit zeta-1 OS=Homo sapiens OX=9606 GN=AP5Z1 PE=1 SV=2" "0.002" "False" "3.216" "2" "2" "2" "2" "807" "88.5" "7.01" "5.35" "2" "DNA metabolism;stress response;transport" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "" "Pf14764" "9907" "ENSG00000242802" "AP5Z1" "hsa:9907; O43299; Q8N3X2; Q96H80" "" "" "0" "0" "0.931" "0.914" "0.872" "0.909" "0.938" "0.912" "0.871" "0.876" "0.873" "778.5" "724.5" "711.7" "678.5" "707.7" "730.5" "709.8" "677.8" "682.0" "679.7" "" "" "" "" "" "" "" "" "" "" "729.4" "599.5" "660.7" "524.5" "603.2" "698.0" "648.6" "601.8" "682.0" "654.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6528342238616596443" "False" "High" "IsMasterProtein" "Q92542" "Nicastrin OS=Homo sapiens OX=9606 GN=NCSTN PE=1 SV=2" "0.002" "False" "3.213" "2" "1" "1" "1" "709" "78.4" "5.99" "3.03" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05450, Pf18266" "23385" "ENSG00000162736" "NCSTN" "hsa:23385; Q5T207; Q5T208; Q86VV5; Q92542" "Alzheimer's disease and miRNA effects; Notch signaling; Inclusion body myositis; Alzheimer's disease; DYRK1A involvement regarding cell proliferation in brain development; Notch signaling pathway" "Amyloid fiber formation; Neutrophil degranulation; Degradation of the extracellular matrix; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; Nuclear signaling by ERBB4; EPH-ephrin mediated repulsion of cells; NOTCH4 Activation and Transmission of Signal to the Nucleus; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; Noncanonical activation of NOTCH3" "20" "0" "1.019" "0.916" "1.083" "1.039" "0.986" "1.056" "0.951" "1.117" "1.053" "104.4" "106.3" "95.6" "113.1" "108.4" "102.9" "110.2" "99.3" "116.6" "109.9" "" "" "" "" "" "" "" "" "" "" "97.8" "88.0" "88.8" "87.4" "92.4" "98.4" "100.7" "88.1" "116.6" "105.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5567467987070279927" "False" "High" "IsMasterProtein" "Q96CV9" "Optineurin OS=Homo sapiens OX=9606 GN=OPTN PE=1 SV=3" "0.002" "False" "3.211" "3" "2" "2" "2" "577" "65.9" "5.17" "4.77" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf11577, Pf16516, Pf18414" "10133" "ENSG00000123240" "OPTN" "B3KP00; D3DRS4; D3DRS8; hsa:10133; Q5T672; Q5T673; Q5T674; Q5T675; Q7LDL9; Q8N562; Q96CV9; Q9UET9; Q9UEV4; Q9Y218" "HDAC6 interactions in the central nervous system" "Regulation of TNFR1 signaling; TNFR1-induced proapoptotic signaling; Regulation of PLK1 Activity at G2/M Transition; TNFR1-induced NF-kappa-B signaling pathway; TBC/RABGAPs" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3862869163996360692" "False" "High" "IsMasterProtein" "Q7LBR1" "Charged multivesicular body protein 1b OS=Homo sapiens OX=9606 GN=CHMP1B PE=1 SV=1" "0.002" "False" "3.209" "9" "2" "3" "2" "199" "22.1" "8.10" "6.16" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "57132" "ENSG00000255112" "CHMP1B" "hsa:57132; Q7LBR1; Q96E89; Q9HD41" "" "" "0" "0" "1.020" "1.038" "1.044" "1.066" "1.123" "0.950" "1.012" "0.962" "0.989" "236.1" "240.8" "245.0" "246.5" "251.8" "265.2" "224.3" "239.0" "227.1" "233.5" "" "" "" "" "" "" "" "" "" "" "221.2" "199.2" "227.5" "190.6" "214.6" "253.4" "204.9" "212.2" "227.1" "224.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6962045687038046175" "False" "High" "IsMasterProtein" "Q8NEC7" "Glutathione S-transferase C-terminal domain-containing protein OS=Homo sapiens OX=9606 GN=GSTCD PE=1 SV=2" "0.002" "False" "3.206" "3" "1" "1" "1" "633" "71.0" "7.78" "0.00" "1" "" "other cell component" "other molecular function" "Pf13679" "79807" "ENSG00000138780" "GSTCD" "A8K8J0; A8MVD3; H9KV97; hsa:79807; Q8NEC7; Q9H8S3" "Metapathway biotransformation Phase I and II" "" "1" "0" "0.888" "0.767" "1.099" "1.048" "1.103" "0.992" "1.042" "1.031" "0.992" "29.8" "26.4" "22.8" "32.7" "31.2" "32.8" "29.5" "31.0" "30.7" "29.5" "" "" "" "" "" "" "" "" "" "" "27.9" "21.9" "21.2" "25.3" "26.6" "31.3" "27.0" "27.5" "30.7" "28.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7691749111498675631" "False" "High" "IsMasterProtein" "O14531" "Dihydropyrimidinase-related protein 4 OS=Homo sapiens OX=9606 GN=DPYSL4 PE=1 SV=2" "0.002" "False" "3.205" "3" "1" "3" "1" "572" "61.8" "7.09" "5.50" "1" "developmental processes" "cytosol" "cytoskeletal activity;other molecular function" "Pf01979" "10570" "ENSG00000151640" "DPYSL4" "B2RMQ1; D3DRG5; hsa:10570; O00240; O14531; Q5T0Q7" "" "CRMPs in Sema3A signaling" "1" "0" "1.097" "1.005" "1.255" "1.228" "1.179" "1.170" "1.263" "1.276" "1.225" "148.9" "163.3" "149.6" "186.9" "182.8" "175.6" "174.3" "188.0" "189.9" "182.4" "" "" "" "" "" "" "" "" "" "" "139.5" "135.2" "138.9" "144.5" "155.9" "167.8" "159.2" "166.9" "189.9" "175.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5430220103658382973" "False" "High" "IsMasterProtein" "Q969Q0" "Ribosomal protein eL42-like OS=Homo sapiens OX=9606 GN=RPL36AL PE=1 SV=3" "0.002" "False" "3.204" "8" "1" "1" "1" "106" "12.5" "10.65" "3.60" "1" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;translational apparatus;nucleus" "other molecular function" "Pf00935" "6166" "ENSG00000165502" "RPL36AL" "hsa:6166; Q3B7A5; Q969Q0" "" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "13" "0" "1.170" "1.034" "1.182" "1.239" "1.130" "1.052" "1.153" "1.154" "1.090" "440.1" "514.8" "455.2" "520.3" "545.4" "497.4" "463.2" "507.4" "507.8" "479.9" "" "" "" "" "" "" "" "" "" "" "412.4" "426.0" "422.6" "402.2" "464.9" "475.2" "423.2" "450.6" "507.8" "462.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8021819990662325449" "False" "High" "IsMasterProtein" "O43760" "Synaptogyrin-2 OS=Homo sapiens OX=9606 GN=SYNGR2 PE=1 SV=1" "0.002" "False" "3.201" "4" "1" "1" "1" "224" "24.8" "4.94" "2.35" "1" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cell component" "" "Pf01284" "9144" "ENSG00000108639" "SYNGR2" "hsa:9144; O43760; O43762; Q3KQZ2; Q658S7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1365521486549272318" "False" "High" "IsMasterProtein" "Q6ICB0" "Desumoylating isopeptidase 1 OS=Homo sapiens OX=9606 GN=DESI1 PE=1 SV=1" "0.002" "False" "3.200" "5" "1" "1" "1" "168" "18.3" "4.94" "3.47" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05903" "27351" "ENSG00000100418" "DESI1" "hsa:27351; Q6ICB0" "" "" "0" "0" "0.952" "0.997" "0.994" "0.988" "1.063" "0.778" "0.932" "0.921" "0.942" "275.8" "262.6" "274.9" "274.1" "272.5" "293.3" "214.5" "257.1" "253.9" "259.7" "" "" "" "" "" "" "" "" "" "" "258.4" "217.3" "255.2" "211.9" "232.2" "280.2" "196.0" "228.3" "253.9" "250.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3695777178307527150" "False" "High" "IsMasterProtein" "Q9BZL1" "Ubiquitin-like protein 5 OS=Homo sapiens OX=9606 GN=UBL5 PE=1 SV=1" "0.002" "False" "3.194" "12" "1" "1" "1" "73" "8.5" "8.44" "3.38" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00240" "59286" "ENSG00000198258" "UBL5" "hsa:59286; Q2NL89; Q9BZL1" "" "mRNA Splicing - Major Pathway" "1" "0" "1.014" "0.867" "0.992" "0.914" "0.851" "0.887" "0.871" "0.830" "0.868" "153.7" "155.9" "133.4" "152.5" "140.5" "130.9" "136.4" "133.9" "127.6" "133.4" "" "" "" "" "" "" "" "" "" "" "144.1" "129.0" "123.8" "117.9" "119.8" "125.0" "124.6" "118.9" "127.6" "128.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3191297454369684242" "False" "High" "IsMasterProtein" "Q8WZ42" "Titin OS=Homo sapiens OX=9606 GN=TTN PE=1 SV=4" "0.002" "False" "3.190" "0" "2" "2" "1" "34350" "3813.7" "6.35" "3.76" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus" "cytoskeletal activity;kinase activity;other molecular function" "Pf00041, Pf00069, Pf02818, Pf07679, Pf09042, Pf18362" "7273" "ENSG00000155657" "TTN" "A6NKB1; E7EQE6; E7ET18; hsa:7273; K7ENY1; Q10465; Q10466; Q15598; Q2XUS3; Q32Q60; Q4U1Z6; Q4ZG20; Q6NSG0; Q6PDB1; Q6PJP0; Q7KYM2; Q7KYN4; Q7KYN5; Q7LDM3; Q7Z2X3; Q8TCG8; Q8WZ42; Q8WZ51; Q8WZ52; Q8WZ53; Q8WZB3; Q92761; Q92762; Q9UD97; Q9UP84; Q9Y6L9" "Striated muscle contraction pathway; Cardiomyocyte signaling pathways converging on titin" "Platelet degranulation ; Striated Muscle Contraction" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8049844811418031107" "False" "High" "IsMasterProtein" "O95707" "Ribonuclease P protein subunit p29 OS=Homo sapiens OX=9606 GN=POP4 PE=1 SV=2" "0.002" "False" "3.189" "4" "1" "3" "1" "220" "25.4" "10.07" "8.35" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01868" "10775" "ENSG00000105171" "POP4" "hsa:10775; O95707; Q5XKL7; Q6FHW9; Q9UQQ3" "" "tRNA processing in the nucleus" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8412715806264131259" "False" "High" "IsMasterProtein" "Q5F1R6" "DnaJ homolog subfamily C member 21 OS=Homo sapiens OX=9606 GN=DNAJC21 PE=1 SV=2" "0.002" "False" "3.185" "3" "1" "1" "1" "531" "62.0" "5.47" "2.23" "1" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00226, Pf12171" "134218" "ENSG00000168724" "DNAJC21" "Q3B7J9; Q5F1R6; Q6P086; Q6ZS43; Q86VC6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8105981666538771075" "False" "High" "IsMasterProtein" "P80297" "Metallothionein-1X OS=Homo sapiens OX=9606 GN=MT1X PE=1 SV=1" "0.002" "False" "3.181" "13" "1" "2" "1" "61" "6.1" "7.96" "5.94" "1" "stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00131" "4501" "ENSG00000187193" "MT1X" "A8MUC7; hsa:4501; P80297" "Copper homeostasis; Zinc homeostasis; Oxidative stress response" "Metallothioneins bind metals" "4" "0" "1.037" "1.062" "0.972" "0.887" "0.875" "0.382" "0.604" "0.831" "0.826" "315.7" "327.3" "335.3" "306.8" "279.9" "276.2" "120.7" "190.5" "262.3" "260.9" "" "" "" "" "" "" "" "" "" "" "295.8" "270.8" "311.3" "237.2" "238.6" "263.9" "110.3" "169.2" "262.3" "251.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4056526521297064515" "False" "High" "IsMasterProtein" "Q14690" "Protein RRP5 homolog OS=Homo sapiens OX=9606 GN=PDCD11 PE=1 SV=3" "0.002" "False" "3.180" "1" "2" "2" "2" "1871" "208.6" "8.87" "2.33" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00575, Pf05843" "22984" "ENSG00000148843" "PDCD11" "hsa:22984; Q14690; Q2TA92; Q5W093; Q6P2J3; Q86VQ8; Q9H4P1" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.458" "1.047" "1.212" "1.196" "1.161" "1.098" "1.061" "1.193" "1.139" "155.7" "227.0" "163.0" "188.8" "186.2" "180.8" "170.9" "165.2" "185.7" "177.3" "" "" "" "" "" "" "" "" "" "" "145.9" "187.8" "151.3" "145.9" "158.7" "172.7" "156.2" "146.6" "185.7" "170.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6923013739007896551" "False" "High" "IsMasterProtein" "P60033" "CD81 antigen OS=Homo sapiens OX=9606 GN=CD81 PE=1 SV=1" "0.002" "False" "3.177" "8" "1" "1" "1" "236" "25.8" "5.29" "2.48" "1" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00335" "975" "ENSG00000110651" "CD81" "hsa:975; P18582; P60033; Q5U0J6" "B cell receptor signaling pathway; Extracellular vesicles in the crosstalk of cardiac cells; IL-18 signaling pathway; 16p11.2 distal deletion syndrome" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4288572419513908439" "False" "High" "IsMasterProtein" "Q8WXG6" "MAP kinase-activating death domain protein OS=Homo sapiens OX=9606 GN=MADD PE=1 SV=2" "0.002" "False" "3.171" "1" "2" "2" "2" "1647" "183.2" "6.04" "4.43" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf02141, Pf03456" "8567" "ENSG00000110514" "MADD" "A8K8S7; B5MEE5; D3DQR4; hsa:8567; O15065; O15293; Q15732; Q15741; Q8IWD7; Q8WXG3; Q8WXG4; Q8WXG5; Q8WXG6; Q8WZ63" "Apoptosis modulation and signaling; Deregulation of Rab and Rab effector genes in bladder cancer; TNF-alpha signaling pathway" "" "3" "0" "0.954" "0.990" "0.946" "1.051" "1.071" "0.927" "0.886" "0.891" "0.904" "297.5" "283.9" "294.4" "281.6" "312.9" "318.7" "275.8" "263.5" "265.1" "269.0" "" "" "" "" "" "" "" "" "" "" "278.8" "234.9" "273.3" "217.7" "266.7" "304.5" "252.0" "234.0" "265.1" "259.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7571054371893401161" "False" "High" "IsMasterProtein" "Q9Y4H2" "Insulin receptor substrate 2 OS=Homo sapiens OX=9606 GN=IRS2 PE=1 SV=2" "0.002" "False" "3.168" "1" "1" "1" "1" "1338" "137.2" "8.65" "3.76" "1" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00169, Pf02174" "8660" "ENSG00000185950" "IRS2" "hsa:8660; Q96RR2; Q9BZG0; Q9Y4H2; Q9Y6I5" "Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; Nonalcoholic fatty liver disease; Insulin signaling; FOXA2 pathway; Alzheimer's disease; EPO receptor signaling; Interferon type I signaling pathways" "Growth hormone receptor signaling; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); RAF/MAP kinase cascade; PI3K Cascade; Interleukin-7 signaling; PI3K/AKT activation; Signaling by Leptin; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; SOS-mediated signalling; IRS activation; Signal attenuation" "38" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8772258242304102193" "False" "High" "IsMasterProtein" "Q9BQE5" "Apolipoprotein L2 OS=Homo sapiens OX=9606 GN=APOL2 PE=1 SV=2" "0.002" "False" "3.165" "3" "1" "1" "1" "337" "37.1" "6.74" "2.72" "1" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;other membranes;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf05461" "23780" "ENSG00000128335" "APOL2" "B0QYK7; hsa:23780; O95915; Q59GW9; Q5TH96; Q969T6; Q9BQE5; Q9BT28; Q9UGT1; Q9UH10" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2213964009562645664" "False" "High" "IsMasterProtein" "Q9Y221" "60S ribosome subunit biogenesis protein NIP7 homolog OS=Homo sapiens OX=9606 GN=NIP7 PE=1 SV=1" "0.002" "False" "3.155" "5" "1" "1" "1" "180" "20.4" "8.51" "2.27" "1" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "Pf03657, Pf17833" "51388" "ENSG00000132603" "NIP7" "B2RD04; hsa:51388; Q9NZZ0; Q9Y221" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7214504578644122811" "False" "High" "IsMasterProtein" "P62942" "Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Homo sapiens OX=9606 GN=FKBP1A PE=1 SV=2" "0.002" "False" "3.154" "13" "1" "2" "1" "108" "11.9" "8.16" "4.27" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00254" "2280" "ENSG00000088832" "FKBP1A" "D3DVW6; hsa:2280; P20071; P62942; Q4VC47; Q6FGD9; Q6LEU3; Q9H103; Q9H566" "Target of rapamycin signaling; Spinal cord injury; Head and neck squamous cell carcinoma; TGF-beta receptor signaling in skeletal dysplasias; Affected pathways in Duchenne muscular dystrophy; Calcium regulation in cardiac cells; TGF-beta receptor signaling" "Potential therapeutics for SARS; mTORC1-mediated signalling; SARS-CoV-1 activates/modulates innate immune responses; TGF-beta receptor signaling activates SMADs; Calcineurin activates NFAT; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); TGFBR1 LBD Mutants in Cancer" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9053349268782207138" "False" "High" "IsMasterProtein" "Q8IYR2" "SET and MYND domain-containing protein 4 OS=Homo sapiens OX=9606 GN=SMYD4 PE=1 SV=3" "0.002" "False" "3.148" "3" "2" "2" "2" "804" "89.2" "6.83" "4.73" "2" "other metabolic processes;developmental processes" "nucleus;other cell component" "other molecular function" "Pf00856, Pf01753" "114826" "ENSG00000186532" "SMYD4" "hsa:114826; Q8IYR2; Q8N1P2; Q8NAT0; Q96LV4; Q96PV2" "Histone modifications" "" "1" "0" "0.959" "1.072" "1.200" "1.244" "1.069" "1.181" "1.079" "0.897" "1.139" "60.0" "57.6" "64.3" "72.0" "74.6" "64.1" "70.8" "64.7" "53.8" "68.3" "" "" "" "" "" "" "" "" "" "" "56.2" "47.6" "59.7" "55.7" "63.6" "61.2" "64.7" "57.5" "53.8" "65.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7450881141775825578" "False" "High" "IsMasterProtein" "Q9H8W3" "Protein FAM204A OS=Homo sapiens OX=9606 GN=FAM204A PE=1 SV=1" "0.002" "False" "3.126" "5" "1" "1" "1" "233" "27.0" "7.91" "3.32" "1" "" "" "" "" "63877" "ENSG00000165669" "FAM204A" "D3DRC6; hsa:63877; Q5T373; Q9H5V5; Q9H8W3" "" "" "0" "0" "1.036" "1.141" "1.135" "1.120" "1.182" "1.038" "1.142" "1.108" "1.080" "143.9" "149.1" "164.2" "163.4" "161.2" "170.0" "149.3" "164.3" "159.5" "155.4" "" "" "" "" "" "" "" "" "" "" "134.8" "123.4" "152.4" "126.3" "137.4" "162.5" "136.5" "145.9" "159.5" "149.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518477556068487686" "False" "High" "IsMasterProtein" "P30046" "D-dopachrome decarboxylase OS=Homo sapiens OX=9606 GN=DDT PE=1 SV=3" "0.002" "False" "3.124" "7" "1" "3" "1" "118" "12.7" "7.30" "9.36" "1" "other metabolic processes;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01187" "1652" "ENSG00000099977; ENSG00000275003" "DDT" "B7Z522; hsa:1652; O00774; O60787; P30046; Q13534" "" "" "0" "0" "0.894" "0.898" "0.939" "0.861" "0.975" "0.825" "0.928" "0.858" "0.925" "204.8" "183.1" "183.9" "192.4" "176.3" "199.6" "168.9" "190.1" "175.7" "189.4" "" "" "" "" "" "" "" "" "" "" "191.9" "151.5" "170.7" "148.7" "150.3" "190.7" "154.4" "168.8" "175.7" "182.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4201705345580193530" "False" "High" "IsMasterProtein" "Q969F9" "BLOC-2 complex member HPS3 OS=Homo sapiens OX=9606 GN=HPS3 PE=1 SV=1" "0.002" "False" "3.119" "1" "1" "1" "1" "1004" "113.7" "6.43" "3.04" "1" "cell organization and biogenesis;transport" "cytosol;other cytoplasmic organelle;other cell component" "" "Pf14761, Pf14763" "84343" "ENSG00000163755" "HPS3" "A8K6G6; hsa:84343; Q8WTV6; Q969F9; Q96AP1; Q96MR3; Q9H608" "" "" "0" "0" "1.019" "0.980" "1.057" "0.991" "0.984" "0.844" "0.936" "0.939" "0.971" "240.2" "244.8" "235.3" "253.9" "238.1" "236.4" "202.8" "224.7" "225.6" "233.3" "" "" "" "" "" "" "" "" "" "" "225.1" "202.5" "218.5" "196.2" "203.0" "225.9" "185.3" "199.5" "225.6" "224.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1655818240381757095" "False" "High" "IsMasterProtein" "Q9NSY1" "BMP-2-inducible protein kinase OS=Homo sapiens OX=9606 GN=BMP2K PE=1 SV=2" "0.002" "False" "3.117" "1" "1" "1" "1" "1161" "129.1" "6.51" "2.15" "1" "other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf15282" "55589" "ENSG00000138756" "BMP2K" "hsa:55589; O94791; Q4W5H2; Q8IYF2; Q8N2G7; Q8NHG9; Q9NSY1; Q9NTG8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3741910088829308609" "False" "High" "IsMasterProtein" "Q9NP66" "High mobility group protein 20A OS=Homo sapiens OX=9606 GN=HMG20A PE=1 SV=1" "0.002" "False" "3.117" "3" "1" "1" "1" "347" "40.1" "6.49" "3.53" "1" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505" "10363" "ENSG00000140382" "HMG20A" "A6NHY3; D3DW78; hsa:10363; Q53G31; Q9NP66; Q9NSF6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4477326506537257431" "False" "High" "IsMasterProtein" "Q5TGJ6" "Hepatoma-derived growth factor-like protein 1 OS=Homo sapiens OX=9606 GN=HDGFL1 PE=1 SV=1" "0.002" "False" "3.114" "3" "1" "1" "1" "251" "27.2" "4.56" "2.26" "1" "cell organization and biogenesis" "nucleus" "" "Pf00855" "154150" "ENSG00000112273" "HDGFL1" "hsa:154150; Q5TGJ6; Q96MJ6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6354667477089484627" "False" "High" "IsMasterProtein" "Q5T2E6" "Armadillo-like helical domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ARMH3 PE=1 SV=1" "0.002" "False" "3.108" "1" "1" "1" "1" "689" "78.7" "6.60" "3.50" "1" "other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf08427" "79591" "ENSG00000120029" "ARMH3" "hsa:79591; Q2TB87; Q5T2E6; Q9H8Z9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-580971408817382446" "False" "High" "IsMasterProtein" "O75956" "Cyclin-dependent kinase 2-associated protein 2 OS=Homo sapiens OX=9606 GN=CDK2AP2 PE=1 SV=1" "0.002" "False" "3.103" "8" "1" "1" "1" "126" "13.1" "9.48" "3.43" "1" "other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf09806" "10263" "ENSG00000167797" "CDK2AP2" "hsa:10263; O75956" "" "" "0" "0" "0.940" "1.033" "0.860" "0.977" "1.032" "0.842" "1.010" "0.995" "1.201" "155.4" "146.1" "160.6" "133.7" "151.8" "160.4" "130.9" "156.9" "154.6" "186.6" "" "" "" "" "" "" "" "" "" "" "145.6" "120.9" "149.1" "103.3" "129.4" "153.2" "119.6" "139.3" "154.6" "179.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5036533815918111608" "False" "High" "IsMasterProtein" "Q9NP72" "Ras-related protein Rab-18 OS=Homo sapiens OX=9606 GN=RAB18 PE=1 SV=1" "0.002" "False" "3.102" "5" "1" "1" "1" "206" "23.0" "5.24" "3.65" "1" "cell organization and biogenesis;transport;developmental processes;signal transduction" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "22931" "ENSG00000099246" "RAB18" "B3KMC7; B7Z333; D3DRW1; hsa:22931; Q53FX8; Q56UN9; Q6FIH1; Q9NP72" "" "Neutrophil degranulation; RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2880199082589634412" "False" "High" "IsMasterProtein" "P30281" "G1/S-specific cyclin-D3 OS=Homo sapiens OX=9606 GN=CCND3 PE=1 SV=2" "0.002" "False" "3.101" "5" "2" "2" "2" "292" "32.5" "7.06" "4.23" "2" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00134, Pf02984" "896" "ENSG00000112576" "CCND3" "B2RD63; B3KQ22; E9PAS4; E9PB36; hsa:896; P30281; Q5T8J0; Q6FG62; Q96F49" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Retinoblastoma gene in cancer; Focal adhesion; Overview of nanoparticle effects; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; G1 to S cell cycle control; Measles virus infection; Pleural mesothelioma; JAK-STAT signaling in the regulation of beta cells; DNA damage response; DNA damage response (only ATM dependent)" "Transcriptional regulation of white adipocyte differentiation; MAPK6/MAPK4 signaling; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Drug-mediated inhibition of CDK4/CDK6 activity; Regulation of RUNX1 Expression and Activity" "24" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5294040977581567700" "False" "High" "IsMasterProtein" "Q9HBF4" "Zinc finger FYVE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZFYVE1 PE=1 SV=1" "0.002" "False" "3.099" "2" "2" "3" "2" "777" "87.1" "7.42" "2.53" "2" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363" "53349" "ENSG00000165861" "ZFYVE1" "hsa:53349; J3KNL9; Q8WYX7; Q96K57; Q9BXP9; Q9HBF4; Q9HCI3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4656669965841171391" "False" "High" "IsMasterProtein" "Q8NBQ5" "Estradiol 17-beta-dehydrogenase 11 OS=Homo sapiens OX=9606 GN=HSD17B11 PE=1 SV=4" "0.002" "False" "3.098" "6" "1" "1" "1" "300" "32.9" "9.17" "0.00" "1" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00106" "51170" "ENSG00000198189" "HSD17B11" "hsa:51170; Q8NBQ5; Q96HF6; Q9UKU4" "" "Estrogen biosynthesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2950616405929129655" "False" "High" "IsMasterProtein" "P54802" "Alpha-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=NAGLU PE=1 SV=2" "0.002" "False" "3.097" "2" "1" "1" "1" "743" "82.2" "6.65" "2.28" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other cytoplasmic organelle" "other molecular function" "Pf05089, Pf12971, Pf12972" "4669" "ENSG00000108784" "NAGLU" "hsa:4669; P54802" "Glycosaminoglycan degradation" "HS-GAG degradation; MPS IIIB - Sanfilippo syndrome B" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8727510044449713303" "False" "High" "IsMasterProtein" "Q9NVX0" "HAUS augmin-like complex subunit 2 OS=Homo sapiens OX=9606 GN=HAUS2 PE=1 SV=1" "0.002" "False" "3.094" "4" "1" "1" "1" "235" "26.9" "7.88" "3.18" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf15003" "55142" "ENSG00000137814" "HAUS2" "C9JH36; hsa:55142; Q9H9B3; Q9NVX0" "" "Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane" "7" "0" "0.975" "1.028" "1.135" "1.031" "1.000" "1.012" "0.983" "0.907" "0.999" "194.7" "189.8" "200.1" "220.9" "200.8" "194.7" "197.1" "191.3" "176.7" "194.6" "" "" "" "" "" "" "" "" "" "" "182.4" "157.0" "185.8" "170.8" "171.1" "186.0" "180.1" "169.9" "176.7" "187.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1058846499056220573" "False" "High" "IsMasterProtein" "Q96CP2" "FLYWCH family member 2 OS=Homo sapiens OX=9606 GN=FLYWCH2 PE=1 SV=1" "0.002" "False" "3.092" "6" "1" "2" "1" "140" "14.6" "8.46" "5.80" "1" "" "" "" "Pf15423" "114984" "ENSG00000162076" "FLYWCH2" "hsa:114984; Q96CP2" "" "" "0" "0" "1.196" "1.260" "1.248" "1.187" "1.144" "1.175" "1.158" "1.214" "1.218" "139.5" "166.8" "175.8" "174.1" "165.6" "159.6" "164.0" "161.6" "169.3" "170.0" "" "" "" "" "" "" "" "" "" "" "130.7" "138.0" "163.2" "134.6" "141.2" "152.5" "149.8" "143.5" "169.3" "163.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8926086327643907621" "False" "High" "IsMasterProtein" "Q6XZF7" "Dynamin-binding protein OS=Homo sapiens OX=9606 GN=DNMBP PE=1 SV=1" "0.002" "False" "3.091" "1" "2" "2" "2" "1577" "177.2" "5.39" "5.40" "2" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00018, Pf00621, Pf03114, Pf07653, Pf14604" "23268" "ENSG00000107554" "DNMBP" "hsa:23268; Q6XZF7; Q8IVY3; Q9Y2L3" "15q11q13 copy number variation" "CDC42 GTPase cycle" "2" "0" "1.001" "0.916" "1.184" "1.040" "0.973" "1.038" "0.995" "0.893" "1.065" "242.2" "242.5" "221.8" "286.8" "251.9" "235.7" "251.3" "241.0" "216.3" "258.0" "" "" "" "" "" "" "" "" "" "" "226.9" "200.6" "205.9" "221.7" "214.7" "225.2" "229.6" "214.0" "216.3" "248.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4415250102849728185" "False" "High" "IsMasterProtein" "Q76FK4" "Nucleolar protein 8 OS=Homo sapiens OX=9606 GN=NOL8 PE=1 SV=1" "0.002" "False" "3.090" "1" "1" "1" "1" "1167" "131.5" "7.09" "3.38" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00076" "55035" "ENSG00000198000; ENSG00000291347" "NOL8" "hsa:55035; Q5TCC7; Q5TCC8; Q5TCD3; Q5TCD5; Q5TCD6; Q5TCD7; Q76D35; Q76FK4; Q7L3E2; Q9H586; Q9H795; Q9H7W7; Q9H9J6; Q9NWA4; Q9NWM4" "" "" "0" "0" "1.049" "0.997" "1.151" "1.091" "1.083" "2.135" "1.884" "1.856" "1.223" "67.9" "71.2" "67.7" "78.1" "74.1" "73.6" "144.9" "127.9" "126.0" "83.1" "" "" "" "" "" "" "" "" "" "" "63.6" "58.9" "62.8" "60.4" "63.2" "70.3" "132.4" "113.6" "126.0" "80.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4465536822655971344" "False" "High" "IsMasterProtein" "Q9UPU7" "TBC1 domain family member 2B OS=Homo sapiens OX=9606 GN=TBC1D2B PE=1 SV=2" "0.002" "False" "3.088" "1" "1" "2" "1" "963" "109.8" "6.16" "6.33" "1" "transport" "cytosol;other cytoplasmic organelle" "enzyme regulator activity" "Pf00169, Pf00566" "23102" "ENSG00000167202" "TBC1D2B" "A7MD42; hsa:23102; Q8N1F9; Q9NXM0; Q9UPU7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9052184028571704461" "False" "High" "IsMasterProtein" "O75865" "Trafficking protein particle complex subunit 6A OS=Homo sapiens OX=9606 GN=TRAPPC6A PE=1 SV=2" "0.002" "False" "3.083" "5" "1" "1" "1" "159" "17.6" "5.26" "2.82" "1" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "" "Pf04051" "79090" "ENSG00000007255" "TRAPPC6A" "hsa:79090; K7ERB1; K7ERQ4; O75865; Q9BQ45; Q9P092" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5839197527488627088" "False" "High" "IsMasterProtein" "P09110" "3-ketoacyl-CoA thiolase, peroxisomal OS=Homo sapiens OX=9606 GN=ACAA1 PE=1 SV=2" "0.002" "False" "3.079" "3" "1" "1" "1" "424" "44.3" "8.44" "2.61" "1" "other metabolic processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00108, Pf02803" "30" "ENSG00000060971" "ACAA1" "G5E935; hsa:30; P09110; Q96CA6" "PPAR-alpha pathway; Nuclear receptors meta-pathway; Amino acid metabolism; PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX)" "Neutrophil degranulation; TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids" "11" "0" "2.575" "1.185" "1.595" "1.402" "1.338" "1.519" "1.011" "1.356" "1.171" "12.6" "32.4" "14.9" "20.1" "17.7" "16.8" "19.1" "12.7" "17.1" "14.7" "" "" "" "" "" "" "" "" "" "" "11.8" "26.8" "13.8" "15.5" "15.0" "16.1" "17.5" "11.3" "17.1" "14.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1677934760849169098" "False" "High" "IsMasterProtein" "Q8IVH4" "Methylmalonic aciduria type A protein, mitochondrial OS=Homo sapiens OX=9606 GN=MMAA PE=1 SV=1" "0.002" "False" "3.071" "2" "1" "1" "1" "418" "46.5" "9.29" "2.73" "1" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf03308" "166785" "ENSG00000151611" "MMAA" "B3KX40; hsa:166785; Q495G7; Q8IVH4" "" "Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM; Cobalamin (Cbl) metabolism" "4" "0" "0.942" "0.987" "0.958" "0.982" "0.929" "0.943" "0.939" "0.920" "1.002" "301.2" "283.7" "297.4" "288.6" "295.9" "279.9" "284.1" "282.7" "277.3" "301.9" "" "" "" "" "" "" "" "" "" "" "282.2" "234.7" "276.1" "223.1" "252.2" "267.4" "259.6" "251.1" "277.3" "290.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5062792901890915106" "False" "High" "IsMasterProtein" "P52895" "Aldo-keto reductase family 1 member C2 OS=Homo sapiens OX=9606 GN=AKR1C2 PE=1 SV=3" "0.002" "False" "3.071" "5" "2" "2" "2" "323" "36.7" "7.49" "4.77" "2" "other metabolic processes;signal transduction;other biological processes" "cytosol" "other molecular function" "Pf00248" "1646" "ENSG00000151632" "AKR1C2" "A8K2N9; B4DKR9; hsa:1646; P52895; Q14133; Q5SR16; Q7M4N1; Q96A71" "Ferroptosis; Alternative pathway of fetal androgen synthesis; Benzo(a)pyrene metabolism; Metapathway biotransformation Phase I and II; Prostaglandin synthesis and regulation" "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Synthesis of bile acids and bile salts via 24-hydroxycholesterol; Synthesis of bile acids and bile salts via 27-hydroxycholesterol" "8" "0" "1.016" "0.959" "1.067" "1.126" "1.075" "1.152" "1.005" "0.977" "1.092" "100.6" "102.2" "96.6" "107.4" "113.4" "108.2" "115.9" "101.2" "98.3" "109.9" "" "" "" "" "" "" "" "" "" "" "94.3" "84.6" "89.6" "83.0" "96.6" "103.4" "105.9" "89.8" "98.3" "105.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4068487784358334043" "False" "High" "IsMasterProtein" "Q8TDX7" "Serine/threonine-protein kinase Nek7 OS=Homo sapiens OX=9606 GN=NEK7 PE=1 SV=1" "0.002" "False" "3.070" "4" "1" "1" "1" "302" "34.5" "8.25" "4.57" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "140609" "ENSG00000151414" "NEK7" "A6NGT8; hsa:140609; Q8TDX7" "Ciliary landscape; EPAC1 and PKA reduction of retinal inflammation" "EML4 and NUDC in mitotic spindle formation; Nuclear Pore Complex (NPC) Disassembly; Activation of NIMA Kinases NEK9, NEK6, NEK7" "5" "0" "0.942" "0.953" "1.065" "0.937" "1.093" "0.880" "1.029" "0.987" "1.046" "334.7" "315.3" "319.0" "356.5" "313.5" "365.9" "294.5" "344.4" "330.3" "350.2" "" "" "" "" "" "" "" "" "" "" "313.6" "260.9" "296.1" "275.6" "267.3" "349.6" "269.1" "305.8" "330.3" "337.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-421989768094974956" "False" "High" "IsMasterProtein" "Q96BM9" "ADP-ribosylation factor-like protein 8A OS=Homo sapiens OX=9606 GN=ARL8A PE=1 SV=1" "0.002" "False" "3.069" "5" "1" "1" "1" "186" "21.4" "7.77" "3.19" "1" "cell cycle OR cell proliferation;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00025" "127829" "ENSG00000143862" "ARL8A" "B3KXD0; hsa:127829; Q96BM9" "" "Neutrophil degranulation" "1" "0" "1.027" "0.879" "1.011" "0.965" "1.149" "0.845" "0.909" "1.051" "1.003" "161.7" "166.0" "142.0" "163.4" "156.0" "185.8" "136.7" "147.0" "169.9" "162.1" "" "" "" "" "" "" "" "" "" "" "151.5" "137.4" "131.9" "126.3" "132.9" "177.5" "124.9" "130.5" "169.9" "156.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7104112355135180301" "False" "High" "IsMasterProtein" "Q9UL26" "Ras-related protein Rab-22A OS=Homo sapiens OX=9606 GN=RAB22A PE=1 SV=2" "0.002" "False" "3.068" "4" "1" "1" "1" "194" "21.8" "8.15" "2.95" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "57403" "ENSG00000124209" "RAB22A" "B3KR86; E1P605; hsa:57403; Q8TF12; Q9H4E6; Q9UL26" "" "RAB geranylgeranylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7156219127776266862" "False" "High" "IsMasterProtein" "Q9BSE5" "Guanidino acid hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=AGMAT PE=1 SV=2" "0.002" "False" "3.065" "3" "1" "1" "1" "352" "37.6" "7.59" "3.11" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00491" "79814" "ENSG00000116771" "AGMAT" "hsa:79814; Q5TDH1; Q9BSE5; Q9H5J3" "" "Agmatine biosynthesis" "1" "0" "1.013" "1.122" "0.927" "1.037" "1.041" "0.936" "0.989" "1.029" "0.973" "316.2" "320.3" "354.7" "293.1" "328.0" "329.1" "296.0" "312.8" "325.3" "307.6" "" "" "" "" "" "" "" "" "" "" "296.3" "265.1" "329.3" "226.5" "279.6" "314.4" "270.5" "277.8" "325.3" "296.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4976528031312254709" "False" "High" "IsMasterProtein" "Q92506" "(3R)-3-hydroxyacyl-CoA dehydrogenase OS=Homo sapiens OX=9606 GN=HSD17B8 PE=1 SV=2" "0.002" "False" "3.065" "3" "1" "1" "1" "261" "27.0" "6.54" "3.36" "1" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf13561" "7923" "ENSG00000112474; ENSG00000204228; ENSG00000225312; ENSG00000228357; ENSG00000228712; ENSG00000232357" "HSD17B8" "A6NLX7; hsa:7923; Q5STP7; Q92506; Q9UIQ1" "" "Fatty acyl-CoA biosynthesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3512709213030635594" "False" "High" "IsMasterProtein" "O95405" "Zinc finger FYVE domain-containing protein 9 OS=Homo sapiens OX=9606 GN=ZFYVE9 PE=1 SV=2" "0.002" "False" "3.062" "1" "1" "1" "1" "1425" "156.3" "5.01" "2.20" "1" "transport;signal transduction" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf11409, Pf11979" "9372" "ENSG00000157077" "ZFYVE9" "hsa:9372; O95405; Q5T0F6; Q5T0F7; Q9UNE1; Q9Y5R7" "TGF-beta signaling pathway; TGF-beta receptor signaling in skeletal dysplasias; TGF-beta receptor signaling" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "984760743341076196" "False" "High" "IsMasterProtein" "Q9Y547" "Intraflagellar transport protein 25 homolog OS=Homo sapiens OX=9606 GN=IFT25 PE=1 SV=1" "0.002" "False" "3.054" "8" "1" "1" "1" "144" "16.3" "5.03" "2.79" "1" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00754" "51668" "ENSG00000081870" "IFT25" "A6NG57; D3DQ45; hsa:51668; Q9Y547; Q9Y684" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); GDNF/RET signaling axis; Alstrom syndrome" "Intraflagellar transport" "6" "0" "1.150" "1.047" "1.400" "1.359" "1.091" "1.234" "1.076" "0.870" "0.962" "47.1" "54.1" "49.3" "65.9" "64.0" "51.4" "58.1" "50.7" "40.9" "45.3" "" "" "" "" "" "" "" "" "" "" "44.1" "44.8" "45.7" "50.9" "54.5" "49.1" "53.0" "45.0" "40.9" "43.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9201189030336339183" "False" "High" "IsMasterProtein" "P62875" "DNA-directed RNA polymerases I, II, and III subunit RPABC5 OS=Homo sapiens OX=9606 GN=POLR2L PE=1 SV=1" "0.002" "False" "3.051" "13" "1" "2" "1" "67" "7.6" "7.77" "3.49" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01194" "5441" "ENSG00000177700" "POLR2L" "hsa:5441; P52436; P62875; Q6FHX3" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "56" "0" "0.980" "1.041" "1.069" "0.995" "0.992" "0.938" "1.082" "0.990" "1.043" "175.1" "171.6" "182.3" "187.2" "174.2" "173.6" "164.2" "189.5" "173.3" "182.6" "" "" "" "" "" "" "" "" "" "" "164.1" "142.0" "169.2" "144.7" "148.5" "165.9" "150.1" "168.2" "173.3" "175.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1301679656055029716" "False" "High" "IsMasterProtein" "Q9BWG6" "Sodium channel modifier 1 OS=Homo sapiens OX=9606 GN=SCNM1 PE=1 SV=1" "0.003" "False" "3.047" "4" "1" "1" "1" "230" "25.9" "8.87" "3.17" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf15803, Pf15805" "100534012; 79005" "ENSG00000163156" "SCNM1" "B4DWR1; hsa:100534012; hsa:79005; Q5JR74; Q9BWG6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7480523710602738279" "False" "High" "IsMasterProtein" "Q9BPZ3" "Polyadenylate-binding protein-interacting protein 2 OS=Homo sapiens OX=9606 GN=PAIP2 PE=1 SV=1" "0.003" "False" "3.042" "6" "1" "1" "1" "127" "15.0" "4.12" "3.63" "1" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf07145" "51247" "ENSG00000120727" "PAIP2" "B2RBI1; D3DQC6; hsa:51247; Q49A06; Q9BPZ3; Q9H0Y5; Q9P0Q8" "" "" "0" "0" "0.995" "0.929" "0.776" "0.855" "0.879" "0.846" "0.888" "0.855" "0.819" "360.1" "358.4" "334.6" "279.5" "307.9" "316.6" "304.8" "319.7" "308.0" "294.8" "" "" "" "" "" "" "" "" "" "" "337.4" "296.6" "310.6" "216.1" "262.4" "302.5" "278.5" "283.9" "308.0" "283.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5139154873677700372" "False" "High" "IsMasterProtein" "Q9H9V9" "2-oxoglutarate and iron-dependent oxygenase JMJD4 OS=Homo sapiens OX=9606 GN=JMJD4 PE=1 SV=3" "0.003" "False" "3.042" "2" "1" "1" "1" "417" "47.4" "5.54" "2.65" "1" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "65094" "ENSG00000081692" "JMJD4" "A0A087WT84; hsa:65094; Q5TBZ1; Q5TBZ6; Q9H970; Q9H9V9" "" "Protein hydroxylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7225180490638560304" "False" "High" "IsMasterProtein" "P51157" "Ras-related protein Rab-28 OS=Homo sapiens OX=9606 GN=RAB28 PE=1 SV=2" "0.003" "False" "3.038" "4" "1" "1" "1" "221" "24.8" "5.97" "2.92" "1" "transport" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf00071" "9364" "ENSG00000157869" "RAB28" "G8JLC5; hsa:9364; P51157; Q8IYR8; Q8NI05" "Ciliopathies" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4833705581656825044" "False" "High" "IsMasterProtein" "Q96RT1" "Erbin OS=Homo sapiens OX=9606 GN=ERBIN PE=1 SV=2" "0.003" "False" "3.035" "1" "2" "2" "2" "1412" "158.2" "5.50" "5.29" "2" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf00595, Pf13855" "55914" "ENSG00000112851" "ERBIN" "A0AVR1; B4E3F1; B7ZLV9; E7EQW9; E9PCR8; hsa:55914; Q1RMD0; Q86W38; Q96RT1; Q9NR18; Q9NW48; Q9ULJ5" "Nucleotide-binding oligomerization domain (NOD) pathway; Nod-like receptor (NLR) signaling pathway; Pathways affected in adenoid cystic carcinoma" "RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "26" "0" "0.924" "0.838" "1.317" "0.944" "1.078" "1.177" "0.839" "0.903" "0.969" "87.0" "80.4" "72.9" "114.6" "82.2" "93.8" "102.4" "73.0" "78.6" "84.3" "" "" "" "" "" "" "" "" "" "" "81.5" "66.5" "67.7" "88.6" "70.0" "89.7" "93.6" "64.9" "78.6" "81.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4535495802418594220" "False" "High" "IsMasterProtein" "Q9H081" "Protein MIS12 homolog OS=Homo sapiens OX=9606 GN=MIS12 PE=1 SV=1" "0.003" "False" "3.030" "4" "1" "1" "1" "205" "24.1" "5.69" "3.86" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf05859" "79003" "ENSG00000167842" "MIS12" "hsa:79003; Q96N24; Q9H081" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.926" "1.053" "0.967" "1.017" "1.101" "0.990" "1.037" "1.102" "0.963" "318.8" "295.2" "335.7" "308.2" "324.1" "351.0" "315.5" "330.7" "351.3" "306.9" "" "" "" "" "" "" "" "" "" "" "298.7" "244.3" "311.7" "238.2" "276.2" "335.3" "288.3" "293.6" "351.3" "295.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "485577591804044204" "False" "High" "IsMasterProtein" "Q96Q45" "Transmembrane protein 237 OS=Homo sapiens OX=9606 GN=TMEM237 PE=1 SV=2" "0.003" "False" "3.029" "2" "1" "1" "1" "408" "45.5" "6.47" "2.91" "1" "cell organization and biogenesis;other biological processes" "other cell component" "" "Pf15383" "65062" "ENSG00000155755" "TMEM237" "B4E1R8; B4E2R8; E9PAR8; E9PBF8; E9PG24; E9PGX0; hsa:65062; Q53TS9; Q53TT2; Q7Z3B6; Q8IZ18; Q8NBF8; Q96CY1; Q96Q45" "Joubert syndrome; Ciliopathies" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7840164925213101578" "False" "High" "IsMasterProtein" "Q9NVW2" "E3 ubiquitin-protein ligase RLIM OS=Homo sapiens OX=9606 GN=RLIM PE=1 SV=3" "0.003" "False" "3.024" "2" "1" "1" "1" "624" "68.5" "7.56" "2.69" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13639" "51132" "ENSG00000131263" "RLIM" "B2RBQ1; D3DTE0; hsa:51132; Q96D38; Q9NVW2; Q9Y598" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3032211375385727038" "False" "High" "IsMasterProtein" "Q15388" "Mitochondrial import receptor subunit TOM20 homolog OS=Homo sapiens OX=9606 GN=TOMM20 PE=1 SV=1" "0.003" "False" "3.023" "9" "1" "1" "1" "145" "16.3" "8.60" "3.01" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;mitochondrion;other cell component" "transporter activity;other molecular function" "Pf02064" "9804" "ENSG00000173726" "TOMM20" "A8K195; hsa:9804; Q15388; Q498B3; Q6IBT4" "" "Ub-specific processing proteases; Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy" "3" "0" "1.793" "1.022" "1.550" "1.419" "1.510" "1.327" "0.978" "1.742" "1.272" "55.8" "100.0" "57.0" "86.5" "79.1" "84.3" "74.1" "54.6" "97.2" "71.0" "" "" "" "" "" "" "" "" "" "" "52.3" "82.8" "52.9" "66.8" "67.5" "80.5" "67.7" "48.5" "97.2" "68.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1388162349834073741" "False" "High" "IsMasterProtein" "P31323" "cAMP-dependent protein kinase type II-beta regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR2B PE=1 SV=3" "0.003" "False" "3.022" "2" "1" "1" "1" "418" "46.3" "4.92" "3.48" "1" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5577" "ENSG00000005249" "PRKAR2B" "A4D0R9; hsa:5577; P31323" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Cannabinoid receptor signaling; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; Sudden infant death syndrome (SIDS) susceptibility pathways" "FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase" "27" "0" "0.972" "1.041" "1.093" "1.047" "1.035" "1.089" "0.985" "1.019" "1.084" "205.1" "199.5" "213.5" "224.2" "214.9" "212.4" "223.5" "202.1" "209.0" "222.3" "" "" "" "" "" "" "" "" "" "" "192.2" "165.1" "198.2" "173.3" "183.2" "202.9" "204.2" "179.4" "209.0" "214.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3357604607996684691" "False" "High" "IsMasterProtein" "Q9NX58" "Cell growth-regulating nucleolar protein OS=Homo sapiens OX=9606 GN=LYAR PE=1 SV=3" "0.003" "False" "3.021" "2" "1" "1" "1" "379" "43.6" "9.57" "3.29" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08790, Pf17848" "55646" "ENSG00000145220" "LYAR" "D3DVS4; hsa:55646; Q6FI78; Q9NX58; Q9NYS1" "" "" "0" "0" "1.281" "1.009" "1.152" "1.425" "1.147" "1.848" "1.849" "1.672" "1.464" "44.8" "57.4" "45.2" "51.6" "63.8" "51.4" "82.8" "82.8" "74.9" "65.6" "" "" "" "" "" "" "" "" "" "" "42.0" "47.5" "42.0" "39.9" "54.4" "49.1" "75.6" "73.5" "74.9" "63.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8127793230594197368" "False" "High" "IsMasterProtein" "Q9ULH1" "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ASAP1 PE=1 SV=4" "0.003" "False" "3.019" "1" "1" "1" "1" "1129" "125.4" "7.31" "3.27" "1" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01412, Pf12796, Pf14604, Pf16746" "50807" "ENSG00000153317" "ASAP1" "B2RNV3; hsa:50807; Q9ULH1" "EGF/EGFR signaling pathway; CCL18 signaling pathway" "VxPx cargo-targeting to cilium" "3" "0" "1.046" "1.078" "1.127" "1.035" "1.012" "1.129" "0.998" "1.064" "1.037" "255.4" "267.1" "275.4" "287.7" "264.4" "258.4" "288.4" "255.0" "271.7" "264.8" "" "" "" "" "" "" "" "" "" "" "239.3" "221.0" "255.6" "222.4" "225.4" "246.8" "263.5" "226.4" "271.7" "254.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3213067895580761470" "False" "High" "IsMasterProtein" "Q96CU9" "FAD-dependent oxidoreductase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FOXRED1 PE=1 SV=2" "0.003" "False" "3.018" "2" "1" "2" "1" "486" "53.8" "7.78" "5.90" "1" "cell organization and biogenesis" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01266" "55572" "ENSG00000110074" "FOXRED1" "B3KN84; B4DHU2; hsa:55572; Q71MG0; Q96CU9; Q9BU39; Q9UKY9" "" "" "0" "0" "0.950" "0.848" "0.942" "0.974" "0.979" "0.914" "0.992" "0.874" "0.953" "267.2" "254.0" "226.6" "251.6" "260.2" "261.7" "244.3" "265.1" "233.5" "254.7" "" "" "" "" "" "" "" "" "" "" "250.4" "210.2" "210.3" "194.5" "221.8" "250.0" "223.2" "235.4" "233.5" "245.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3818906983370151673" "False" "High" "IsMasterProtein" "Q8ND76" "Cyclin-Y OS=Homo sapiens OX=9606 GN=CCNY PE=1 SV=2" "0.003" "False" "3.017" "5" "1" "1" "1" "341" "39.3" "7.20" "2.68" "1" "cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00134" "219771" "ENSG00000108100" "CCNY" "B7ZKX9; D3DRY9; hsa:219771; Q2M3V4; Q2TU96; Q6NT86; Q7Z4U7; Q8ND76; Q8TEX2; Q8TEX3; Q96M99; Q96P45" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8712581138028706155" "False" "High" "IsMasterProtein" "Cont_P02081" "Hemoglobin fetal subunit beta OS=Bos taurus OX=9913 PE=1 SV=1" "0.003" "True" "3.015" "6" "1" "1" "1" "145" "15.8" "7.03" "2.66" "1" "other metabolic processes;transport;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00042" "104983812; 109569915; 109569938; 511735" "ENSBIXG00000000751; ENSBTAG00000038748" "LOC104983812; LOC109569915; LOC113905586" "A0A4W2CHH0; A0A6P3GXP4; A0A6P5D2L1; bbis:104983812; biu:109569915; biu:109569938; bta:511735; P02081; Q3SX09" "" "" "0" "0" "0.975" "0.886" "1.187" "1.296" "1.328" "1.226" "1.109" "0.969" "1.004" "66.6" "65.0" "59.0" "79.1" "86.3" "88.5" "81.7" "73.9" "64.5" "66.9" "" "" "" "" "" "" "" "" "" "" "62.4" "53.8" "54.8" "61.1" "73.6" "84.5" "74.6" "65.6" "64.5" "64.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1745587393754728304" "False" "High" "IsMasterProtein" "Q9NQZ2" "Something about silencing protein 10 OS=Homo sapiens OX=9606 GN=UTP3 PE=1 SV=1" "0.003" "False" "3.014" "2" "1" "1" "1" "479" "54.5" "5.62" "3.10" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf04000, Pf09368" "57050" "ENSG00000132467" "UTP3" "hsa:57050; Q6FI82; Q9NQZ2" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8485123881553311665" "False" "High" "IsMasterProtein" "Q8TEB1" "DDB1- and CUL4-associated factor 11 OS=Homo sapiens OX=9606 GN=DCAF11 PE=1 SV=1" "0.003" "False" "3.008" "1" "1" "1" "1" "546" "61.6" "6.40" "3.46" "1" "protein metabolism;other metabolic processes" "nucleus;other cell component" "" "Pf00400" "80344" "ENSG00000100897; ENSG00000284796" "DCAF11" "B3KQ83; D3DS56; hsa:80344; Q5D039; Q86U00; Q86U39; Q8NDN2; Q8TEB1; Q9H2J0; Q9H3A3; Q9H5C9" "Ciliary landscape" "Neddylation" "2" "0" "0.898" "0.984" "0.939" "1.006" "1.019" "0.945" "0.955" "1.025" "1.006" "317.9" "285.5" "312.9" "298.6" "320.0" "324.0" "300.5" "303.7" "325.8" "319.8" "" "" "" "" "" "" "" "" "" "" "297.9" "236.2" "290.5" "230.9" "272.7" "309.6" "274.6" "269.7" "325.8" "307.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2435225049251902172" "False" "High" "IsMasterProtein" "Q8NEY8" "Periphilin-1 OS=Homo sapiens OX=9606 GN=PPHLN1 PE=1 SV=2" "0.003" "False" "3.004" "2" "1" "1" "1" "458" "52.7" "9.11" "3.22" "1" "cell organization and biogenesis;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf11488" "51535" "ENSG00000134283" "PPHLN1" "E9PAX8; hsa:51535; Q86YT2; Q8IXN3; Q8NEY8; Q8TB09; Q96NB9; Q9NXL4; Q9P0P6; Q9P0R9" "" "" "0" "0" "1.001" "1.041" "1.067" "1.137" "1.195" "1.302" "1.367" "1.468" "1.250" "271.3" "271.5" "282.3" "289.3" "308.5" "324.0" "353.1" "370.8" "398.3" "339.1" "" "" "" "" "" "" "" "" "" "" "254.2" "224.7" "262.1" "223.7" "262.9" "309.6" "322.6" "329.2" "398.3" "326.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2556880978610824670" "False" "High" "IsMasterProtein" "P62256" "Ubiquitin-conjugating enzyme E2 H OS=Homo sapiens OX=9606 GN=UBE2H PE=1 SV=1" "0.003" "False" "3.003" "4" "1" "1" "1" "183" "20.6" "4.67" "4.06" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179" "7328" "ENSG00000186591" "UBE2H" "A4D1L6; C9JY93; hsa:7328; P37286; P62256; Q7Z6F4" "Ciliary landscape" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "3" "0" "1.042" "1.021" "1.094" "1.112" "1.109" "0.971" "1.147" "1.135" "1.128" "427.4" "445.2" "436.3" "467.7" "475.1" "473.8" "415.0" "490.3" "484.9" "482.0" "" "" "" "" "" "" "" "" "" "" "400.4" "368.4" "405.0" "361.5" "404.9" "452.7" "379.2" "435.3" "484.9" "464.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4977571995799431172" "False" "High" "IsMasterProtein" "P17947" "Transcription factor PU.1 OS=Homo sapiens OX=9606 GN=SPI1 PE=1 SV=2" "0.003" "False" "2.992" "3" "1" "1" "1" "270" "31.1" "6.80" "4.05" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178" "6688" "ENSG00000066336" "SPI1" "hsa:6688; P17947" "RANKL/RANK signaling pathway; Hematopoietic stem cell differentiation; Development of pulmonary dendritic cells and macrophage subsets; ApoE and miR-146 in inflammation and atherosclerosis; Prion disease pathway; Acute myeloid leukemia; Type II interferon signaling" "Transcriptional regulation of granulopoiesis; RUNX1 regulates transcription of genes involved in differentiation of HSCs" "9" "0" "0.929" "1.003" "0.945" "0.968" "1.007" "1.026" "0.971" "1.022" "1.023" "401.5" "372.8" "402.8" "379.2" "388.5" "404.4" "411.7" "390.0" "410.3" "410.6" "" "" "" "" "" "" "" "" "" "" "376.2" "308.5" "373.9" "293.1" "331.1" "386.4" "376.2" "346.3" "410.3" "395.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6471177956918212945" "False" "High" "IsMasterProtein" "Q9Y458" "T-box transcription factor TBX22 OS=Homo sapiens OX=9606 GN=TBX22 PE=1 SV=3" "0.003" "False" "2.992" "2" "1" "1" "1" "520" "57.9" "7.33" "3.33" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00907" "50945" "ENSG00000122145; ENSG00000277800" "TBX22" "hsa:50945; Q5JZ06; Q96LC0; Q9HBF1; Q9Y458" "" "" "0" "0" "0.971" "0.874" "0.915" "0.956" "1.057" "1.083" "0.950" "0.894" "0.922" "161.6" "156.9" "141.2" "147.8" "154.6" "170.9" "175.1" "153.5" "144.4" "149.0" "" "" "" "" "" "" "" "" "" "" "151.5" "129.8" "131.1" "114.3" "131.8" "163.3" "160.0" "136.3" "144.4" "143.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "499510966834701259" "False" "High" "IsMasterProtein" "Q96GS4" "BLOC-1-related complex subunit 6 OS=Homo sapiens OX=9606 GN=BORCS6 PE=1 SV=2" "0.003" "False" "2.991" "3" "1" "1" "1" "357" "37.2" "5.76" "3.01" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf10157" "54785" "ENSG00000196544" "BORCS6" "hsa:54785; Q53HS4; Q96GS4; Q9NXW8" "" "" "0" "0" "1.063" "1.172" "1.173" "1.132" "1.111" "1.143" "1.057" "1.033" "1.090" "206.4" "219.3" "242.0" "242.1" "233.7" "229.2" "235.9" "218.3" "213.1" "225.0" "" "" "" "" "" "" "" "" "" "" "193.4" "181.5" "224.6" "187.1" "199.2" "219.0" "215.5" "193.8" "213.1" "216.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7152432727454643144" "False" "High" "IsMasterProtein" "Q6PII3" "Coiled-coil domain-containing protein 174 OS=Homo sapiens OX=9606 GN=CCDC174 PE=1 SV=3" "0.003" "False" "2.989" "2" "1" "1" "1" "467" "53.9" "6.33" "2.67" "1" "" "nucleus" "" "Pf13300" "51244" "ENSG00000154781" "CCDC174" "hsa:51244; Q6PII3; Q96CS5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2459990340720831068" "False" "High" "IsMasterProtein" "Q8N1G1" "RNA exonuclease 1 homolog OS=Homo sapiens OX=9606 GN=REXO1 PE=1 SV=3" "0.003" "False" "2.988" "1" "1" "2" "1" "1221" "131.4" "8.95" "4.95" "1" "" "nucleus" "nucleic acid binding activity;other molecular function" "Pf15870" "57455" "ENSG00000079313" "REXO1" "hsa:57455; Q8N1G1; Q9ULT2" "" "" "0" "0" "1.041" "0.947" "1.149" "1.038" "1.007" "0.932" "0.970" "0.942" "1.021" "391.3" "407.3" "370.5" "449.6" "406.1" "393.9" "364.6" "379.5" "368.7" "399.6" "" "" "" "" "" "" "" "" "" "" "366.6" "337.1" "344.0" "347.5" "346.2" "376.4" "333.1" "337.0" "368.7" "384.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3266136317046350400" "False" "High" "IsMasterProtein" "Q70Z53" "Protein FRA10AC1 OS=Homo sapiens OX=9606 GN=FRA10AC1 PE=1 SV=3" "0.003" "False" "2.984" "3" "1" "1" "1" "315" "37.5" "8.10" "3.64" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf09725" "118924" "ENSG00000148690" "FRA10AC1" "C9JCR4; C9JCR5; C9JMY4; hsa:118924; Q70Z49; Q70Z50; Q70Z51; Q70Z52; Q70Z53; Q8N293; Q8WVH5; Q96JQ8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5799699992188837800" "False" "High" "IsMasterProtein" "Q969X0" "RILP-like protein 2 OS=Homo sapiens OX=9606 GN=RILPL2 PE=1 SV=1" "0.003" "False" "2.982" "4" "1" "1" "1" "211" "24.0" "4.98" "2.18" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf11461" "196383" "ENSG00000150977" "RILPL2" "hsa:196383; Q969X0" "" "" "0" "0" "0.931" "0.954" "0.923" "0.903" "1.051" "0.877" "0.916" "1.000" "1.083" "132.9" "123.8" "126.8" "122.6" "120.1" "139.7" "116.6" "121.8" "133.0" "144.0" "" "" "" "" "" "" "" "" "" "" "124.5" "102.4" "117.7" "94.8" "102.4" "133.4" "106.5" "108.1" "133.0" "138.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5567026577194719019" "False" "High" "IsMasterProtein" "Q9Y2Z9" "Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial OS=Homo sapiens OX=9606 GN=COQ6 PE=1 SV=2" "0.003" "False" "2.981" "2" "1" "1" "1" "468" "50.8" "7.30" "3.10" "1" "other metabolic processes" "other membranes;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf01494" "51004" "ENSG00000119723" "COQ6" "B7Z3K8; hsa:51004; Q53GG6; Q86U30; Q96CA1; Q96CK2; Q9Y2Z9" "Nephrotic syndrome" "Ubiquinol biosynthesis" "2" "0" "1.147" "0.888" "1.152" "1.269" "1.184" "1.072" "1.083" "1.039" "1.031" "66.7" "76.5" "59.3" "76.8" "84.6" "79.0" "71.5" "72.2" "69.3" "68.8" "" "" "" "" "" "" "" "" "" "" "62.5" "63.3" "55.0" "59.4" "72.1" "75.5" "65.3" "64.1" "69.3" "66.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "859606760973151215" "False" "High" "IsMasterProtein" "Q562F6" "Shugoshin 2 OS=Homo sapiens OX=9606 GN=SGO2 PE=1 SV=2" "0.003" "False" "2.981" "1" "1" "1" "1" "1265" "144.7" "7.91" "2.75" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "" "151246" "ENSG00000163535" "SGO2" "hsa:151246; Q53RR9; Q53T20; Q562F6; Q86XY4; Q8IWK2; Q8IZK1; Q8N1Q5; Q96LQ3" "Cohesin complex - Cornelia de Lange syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3652930338733713034" "False" "High" "IsMasterProtein" "Q8N9E0" "Protein FAM133A OS=Homo sapiens OX=9606 GN=FAM133A PE=1 SV=1" "0.003" "False" "2.980" "3" "1" "1" "1" "248" "28.9" "10.10" "3.90" "1" "" "" "" "" "286499" "ENSG00000179083" "FAM133A" "hsa:286499; Q8N9E0" "" "" "0" "0" "1.115" "1.160" "1.186" "1.195" "1.157" "1.227" "1.245" "1.151" "1.184" "358.4" "399.5" "415.6" "424.9" "428.1" "414.4" "439.9" "446.0" "412.5" "424.4" "" "" "" "" "" "" "" "" "" "" "335.8" "330.6" "385.8" "328.5" "364.9" "396.0" "401.9" "396.0" "412.5" "408.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2708904731044144793" "False" "High" "IsMasterProtein" "Q7Z3K6" "Mesoderm induction early response protein 3 OS=Homo sapiens OX=9606 GN=MIER3 PE=1 SV=2" "0.003" "False" "2.978" "1" "1" "2" "1" "550" "61.4" "4.51" "5.32" "1" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf19426" "166968" "ENSG00000155545" "MIER3" "B4DRI9; B8ZZQ0; hsa:166968; Q5CZI0; Q68CS3; Q6MZS7; Q7Z3K6; Q86YG8; Q8NA13" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6921354145935856461" "False" "High" "IsMasterProtein" "Q5TGY1" "Transmembrane and coiled-coil domain-containing protein 4 OS=Homo sapiens OX=9606 GN=TMCO4 PE=1 SV=1" "0.003" "False" "2.978" "2" "1" "1" "1" "634" "67.9" "5.85" "2.64" "1" "" "other membranes" "" "Pf05277" "255104" "ENSG00000162542" "TMCO4" "hsa:255104; Q5TGY1; Q5TGY2; Q6MZN5; Q7Z6K6; Q9UQP4; Q9Y3K1" "" "" "0" "0" "0.957" "1.072" "1.052" "1.128" "1.033" "1.000" "0.871" "0.823" "1.120" "30.4" "29.1" "32.6" "32.0" "34.3" "31.4" "30.4" "26.5" "25.0" "34.0" "" "" "" "" "" "" "" "" "" "" "28.5" "24.1" "30.2" "24.7" "29.2" "30.0" "27.8" "23.5" "25.0" "32.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7691038781667592311" "False" "High" "IsMasterProtein" "O94864" "STAGA complex 65 subunit gamma OS=Homo sapiens OX=9606 GN=SUPT7L PE=1 SV=1" "0.003" "False" "2.976" "2" "1" "1" "1" "414" "46.2" "5.12" "2.58" "1" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf07524" "9913" "ENSG00000119760" "SUPT7L" "B4E3W3; hsa:9913; O94864; Q6IB21; Q9H2T6" "" "HATs acetylate histones" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2084755087725056383" "False" "High" "IsMasterProtein" "P05023" "Sodium/potassium-transporting ATPase subunit alpha-1 OS=Homo sapiens OX=9606 GN=ATP1A1 PE=1 SV=1" "0.003" "False" "2.975" "2" "2" "2" "2" "1023" "112.8" "5.49" "2.39" "2" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf00122, Pf00689, Pf00690, Pf13246" "476" "ENSG00000163399" "ATP1A1" "B2RBR6; B7Z2T5; B7Z3U6; F5H3A1; hsa:476; P05023; Q16689; Q6LDM4; Q9UCN1; Q9UJ20; Q9UJ21" "Pre-implantation embryo; Proximal tubule transport; Arsenic metabolism and reactive oxygen species generation" "Potential therapeutics for SARS; Ion homeostasis; Ion transport by P-type ATPases" "6" "0" "1.019" "1.033" "1.087" "1.082" "1.088" "1.029" "1.043" "1.025" "1.040" "351.0" "357.6" "362.5" "381.6" "379.8" "382.0" "361.2" "366.2" "359.8" "365.1" "" "" "" "" "" "" "" "" "" "" "328.9" "295.9" "336.5" "295.0" "323.7" "364.9" "330.1" "325.1" "359.8" "351.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5874507189654450183" "False" "High" "IsMasterProtein" "P50542" "Peroxisomal targeting signal 1 receptor OS=Homo sapiens OX=9606 GN=PEX5 PE=1 SV=3" "0.003" "False" "2.975" "2" "1" "1" "1" "639" "70.8" "4.54" "3.43" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13181" "5830" "ENSG00000139197; ENSG00000288217" "PEX5" "A8K891; B4DZ45; B7ZAD5; D3DUT8; hsa:5830; P50542; Q15115; Q15266; Q96FN7" "1p36 copy number variation syndrome" "Pexophagy" "2" "0" "0.935" "1.032" "1.020" "1.003" "1.018" "0.929" "0.977" "0.993" "0.967" "370.9" "346.9" "382.7" "378.2" "372.1" "377.5" "344.8" "362.6" "368.2" "358.9" "" "" "" "" "" "" "" "" "" "" "347.6" "287.0" "355.3" "292.4" "317.1" "360.7" "315.0" "321.9" "368.2" "345.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9163044576809599647" "False" "High" "IsMasterProtein" "P0DPB6" "DNA-directed RNA polymerases I and III subunit RPAC2 OS=Homo sapiens OX=9606 GN=POLR1D PE=1 SV=1" "0.003" "False" "2.973" "10" "1" "1" "1" "133" "15.2" "5.80" "2.86" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01193, Pf13656" "51082" "ENSG00000186184" "POLR1D" "hsa:51082; P0DPB6; Q5TBX2; Q96BR3; Q9Y2S0" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "" "4" "0" "1.244" "1.066" "1.224" "1.143" "1.130" "1.144" "1.184" "1.040" "1.165" "164.9" "205.1" "175.7" "201.9" "188.4" "186.4" "188.6" "195.3" "171.5" "192.0" "" "" "" "" "" "" "" "" "" "" "154.5" "169.7" "163.1" "156.1" "160.6" "178.1" "172.3" "173.4" "171.5" "184.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6961915596553006747" "False" "High" "IsMasterProtein" "Q9Y6J0" "Calcineurin-binding protein cabin-1 OS=Homo sapiens OX=9606 GN=CABIN1 PE=1 SV=1" "0.003" "False" "2.972" "0" "1" "1" "1" "2220" "246.2" "6.02" "3.07" "1" "cell organization and biogenesis;signal transduction" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf09047" "23523" "ENSG00000099991" "CABIN1" "G5E9F3; hsa:23523; Q6PHY0; Q9Y460; Q9Y6J0" "Calcium mediated T-cell apoptosis involved in inclusion body myositis" "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "2" "0" "1.064" "1.059" "1.112" "1.041" "1.038" "1.070" "1.151" "1.125" "1.048" "154.2" "164.1" "163.4" "171.6" "160.5" "160.0" "165.0" "177.5" "173.5" "161.7" "" "" "" "" "" "" "" "" "" "" "144.5" "135.8" "151.7" "132.6" "136.8" "152.9" "150.8" "157.6" "173.5" "155.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5432716996293136503" "False" "High" "IsMasterProtein" "P05161" "Ubiquitin-like protein ISG15 OS=Homo sapiens OX=9606 GN=ISG15 PE=1 SV=5" "0.003" "False" "2.971" "8" "1" "1" "1" "165" "17.9" "7.44" "2.63" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00240" "9636" "ENSG00000187608" "ISG15" "hsa:9636; P05161; Q5SVA4; Q7Z2G2; Q96GF0" "Novel intracellular components of RIG-I-like receptor pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; Cytosolic DNA-sensing pathway; p53 transcriptional gene network; Extrafollicular and follicular B cell activation by SARS-CoV-2; 1p36 copy number variation syndrome; HDAC6 interactions in the central nervous system; Type II interferon signaling" "RSV-host interactions; PKR-mediated signaling; ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon alpha/beta signaling; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling" "17" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2168737288158195697" "False" "High" "IsMasterProtein" "Q9Y2K1" "Zinc finger and BTB domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZBTB1 PE=1 SV=3" "0.003" "False" "2.955" "1" "1" "1" "1" "713" "82.0" "6.39" "2.48" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "22890" "ENSG00000126804" "ZBTB1" "A8K6S8; hsa:22890; Q86SW8; Q9Y2K1" "" "" "0" "0" "0.882" "0.930" "1.304" "0.901" "0.876" "1.329" "0.913" "0.935" "0.848" "50.2" "44.3" "46.7" "65.5" "45.2" "44.0" "66.7" "45.9" "46.9" "42.6" "" "" "" "" "" "" "" "" "" "" "47.0" "36.6" "43.3" "50.6" "38.5" "42.0" "61.0" "40.7" "46.9" "41.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2612097907356743072" "False" "High" "IsMasterProtein" "Q96HA8" "Protein N-terminal glutamine amidohydrolase OS=Homo sapiens OX=9606 GN=NTAQ1 PE=1 SV=2" "0.003" "False" "2.954" "5" "1" "1" "1" "205" "23.7" "5.78" "2.53" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf09764" "55093" "ENSG00000156795" "NTAQ1" "B4DE68; hsa:55093; Q96HA8; Q9NW95" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1627710569246967084" "False" "High" "IsMasterProtein" "P11831" "Serum response factor OS=Homo sapiens OX=9606 GN=SRF PE=1 SV=1" "0.003" "False" "2.953" "2" "1" "2" "1" "508" "51.6" "8.10" "5.23" "1" "cell adhesion;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319" "6722" "ENSG00000112658" "SRF" "hsa:6722; P11831; Q5T648" "Heart development; SRF and miRs in smooth muscle differentiation and proliferation; Genes targeted by miRNAs in adipocytes; Cell differentiation - expanded index; Cell differentiation - index; Mesodermal commitment pathway; Mesodermal commitment pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; PDGFR-beta pathway; Envelope proteins and their potential roles in EDMD physiopathology; 22q11.2 copy number variation syndrome; Insulin signaling; Orexin receptor pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling" "RHO GTPases Activate Formins; NGF-stimulated transcription; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Cardiogenesis; Regulation of NPAS4 gene transcription" "22" "0" "0.958" "0.977" "0.993" "0.986" "0.977" "1.028" "0.945" "1.001" "1.012" "590.3" "565.8" "576.9" "586.0" "582.3" "576.6" "606.7" "558.0" "591.0" "597.5" "" "" "" "" "" "" "" "" "" "" "553.1" "468.2" "535.6" "453.0" "496.3" "550.9" "554.3" "495.4" "591.0" "575.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5837225809424381126" "False" "High" "IsMasterProtein" "P51826" "AF4/FMR2 family member 3 OS=Homo sapiens OX=9606 GN=AFF3 PE=1 SV=3" "0.003" "False" "2.949" "1" "1" "1" "1" "1226" "133.4" "8.10" "3.38" "1" "developmental processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05110, Pf18875, Pf18876" "3899" "ENSG00000144218" "AFF3" "B7ZM46; B9EGL9; D3DVI6; P51826; Q53RD6; Q53S47; Q53SI6; Q53TB9; Q59F27; Q8IWJ5" "" "" "0" "0" "1.147" "1.085" "1.152" "1.119" "1.042" "1.293" "1.155" "1.156" "1.139" "111.1" "127.5" "120.5" "128.0" "124.3" "115.8" "143.7" "128.4" "128.5" "126.6" "" "" "" "" "" "" "" "" "" "" "104.1" "105.5" "111.9" "99.0" "106.0" "110.7" "131.3" "114.0" "128.5" "121.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3462028508883828896" "False" "High" "IsMasterProtein" "O60318" "Germinal-center associated nuclear protein OS=Homo sapiens OX=9606 GN=MCM3AP PE=1 SV=2" "0.003" "False" "2.947" "0" "1" "1" "1" "1980" "218.3" "6.39" "2.81" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03399, Pf16766, Pf16768, Pf16769" "8888" "ENSG00000160294" "MCM3AP" "C9JL56; hsa:8888; O60318; Q2M3C1; Q6PJP6; Q9BSY5; Q9UMT4" "" "" "0" "0" "1.014" "0.989" "1.053" "0.984" "1.036" "1.142" "1.005" "1.004" "1.044" "118.6" "120.3" "117.3" "124.9" "116.7" "122.9" "135.5" "119.3" "119.1" "123.8" "" "" "" "" "" "" "" "" "" "" "111.1" "99.5" "108.9" "96.6" "99.4" "117.4" "123.8" "105.9" "119.1" "119.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5511043592146931857" "False" "High" "IsMasterProtein" "Q9BSB4" "Autophagy-related protein 101 OS=Homo sapiens OX=9606 GN=ATG101 PE=1 SV=1" "0.003" "False" "2.946" "4" "1" "1" "1" "218" "25.0" "6.15" "3.57" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf07855" "60673" "ENSG00000123395" "ATG101" "hsa:60673; Q9BSB4; Q9HAE2; Q9HBN1" "Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5331704730055142476" "False" "High" "IsMasterProtein" "Q8IVB5" "LIX1-like protein OS=Homo sapiens OX=9606 GN=LIX1L PE=1 SV=1" "0.003" "False" "2.945" "4" "2" "2" "2" "337" "36.5" "8.56" "4.60" "2" "cell organization and biogenesis;other metabolic processes" "other cell component" "" "Pf14954" "128077" "ENSG00000271601" "LIX1L" "hsa:128077; Q6AI36; Q8IVB5" "" "" "0" "0" "1.082" "1.021" "1.123" "0.973" "1.041" "1.000" "0.912" "0.974" "1.044" "442.2" "478.6" "451.3" "496.4" "430.1" "460.5" "442.2" "403.3" "430.7" "461.7" "" "" "" "" "" "" "" "" "" "" "414.3" "396.0" "419.0" "383.7" "366.6" "439.9" "404.1" "358.1" "430.7" "444.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2666601626281135846" "False" "High" "IsMasterProtein" "Q92551" "Inositol hexakisphosphate kinase 1 OS=Homo sapiens OX=9606 GN=IP6K1 PE=1 SV=3" "0.003" "False" "2.944" "2" "1" "1" "1" "441" "50.2" "7.24" "3.16" "1" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf03770" "9807" "ENSG00000176095" "IP6K1" "A8K157; A8MUX4; hsa:9807; Q7L3I7; Q92551; Q96E38" "" "Synthesis of pyrophosphates in the cytosol; Synthesis of IPs in the nucleus" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2132288438487461579" "False" "High" "IsMasterProtein" "Q9BV68" "E3 ubiquitin-protein ligase RNF126 OS=Homo sapiens OX=9606 GN=RNF126 PE=1 SV=2" "0.003" "False" "2.944" "3" "1" "1" "1" "311" "33.8" "5.47" "3.44" "1" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13639, Pf14369" "55658" "ENSG00000070423" "RNF126" "hsa:55658; Q9BV68; Q9NWX1" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2783430516031168393" "False" "High" "IsMasterProtein" "Q8IYT2" "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 OS=Homo sapiens OX=9606 GN=CMTR2 PE=1 SV=2" "0.003" "False" "2.934" "1" "1" "1" "1" "770" "88.1" "7.01" "3.20" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf01728" "55783" "ENSG00000180917" "CMTR2" "B2RCD5; D3DWS1; hsa:55783; Q8IYT2; Q8NE77; Q8NFR5; Q9H8Z4; Q9NUS3; Q9NXF5" "Pathways affected in adenoid cystic carcinoma" "" "1" "0" "0.968" "0.953" "1.101" "1.007" "0.978" "1.035" "1.083" "1.006" "1.047" "210.8" "204.1" "201.0" "232.1" "212.3" "206.2" "218.2" "228.4" "212.2" "220.7" "" "" "" "" "" "" "" "" "" "" "197.6" "168.9" "186.6" "179.4" "181.0" "197.0" "199.3" "202.8" "212.2" "212.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4171853106673834253" "False" "High" "IsMasterProtein" "Q9BVV6" "Protein TALPID3 OS=Homo sapiens OX=9606 GN=KIAA0586 PE=1 SV=4" "0.003" "False" "2.934" "1" "1" "1" "1" "1533" "169.2" "5.54" "0.00" "1" "cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;other cell component" "" "Pf15324" "9786" "ENSG00000100578" "KIAA0586" "B4DZB6; E7EWM8; hsa:9786; J3KQH9; O60328; Q6NYC6; Q6UV20; Q9BVV6" "Joubert syndrome; Ciliopathies" "" "2" "0" "1.135" "0.717" "1.425" "1.083" "0.610" "1.190" "0.771" "0.555" "0.942" "173.6" "197.0" "124.5" "247.3" "188.0" "105.8" "206.5" "133.7" "96.3" "163.4" "" "" "" "" "" "" "" "" "" "" "162.6" "163.0" "115.6" "191.2" "160.3" "101.1" "188.7" "118.8" "96.3" "157.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6446918777604146828" "False" "High" "IsMasterProtein" "Q8N344" "Mesoderm induction early response protein 2 OS=Homo sapiens OX=9606 GN=MIER2 PE=1 SV=2" "0.003" "False" "2.930" "1" "1" "1" "1" "545" "59.9" "4.64" "2.96" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf01448" "54531" "ENSG00000105556" "MIER2" "hsa:54531; Q8N344; Q9ULM7" "" "" "0" "0" "0.946" "0.965" "1.095" "1.089" "1.056" "1.005" "0.969" "0.895" "0.959" "343.1" "324.7" "331.1" "375.8" "373.6" "362.2" "344.9" "332.5" "307.2" "329.1" "" "" "" "" "" "" "" "" "" "" "321.5" "268.6" "307.4" "290.5" "318.4" "346.0" "315.1" "295.2" "307.2" "316.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6544422487784178027" "False" "High" "IsMasterProtein" "Q8IVW6" "AT-rich interactive domain-containing protein 3B OS=Homo sapiens OX=9606 GN=ARID3B PE=1 SV=2" "0.003" "False" "2.927" "1" "1" "1" "1" "561" "60.6" "7.52" "2.66" "1" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf01388" "10620" "ENSG00000179361" "ARID3B" "hsa:10620; O95443; Q59HC9; Q6P9C9; Q8IVW6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3526658263404779392" "False" "High" "IsMasterProtein" "Q9UBI1" "COMM domain-containing protein 3 OS=Homo sapiens OX=9606 GN=COMMD3 PE=1 SV=1" "0.003" "False" "2.922" "4" "1" "1" "1" "195" "22.1" "5.99" "2.31" "1" "transport" "non-structural extracellular;nucleus;other cell component" "" "Pf07258" "23412" "ENSG00000148444" "COMMD3" "D3DRU7; hsa:23412; Q5T8Y9; Q9UBI1" "" "Neddylation; Neutrophil degranulation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3478129203947577365" "False" "High" "IsMasterProtein" "Q93075" "Putative deoxyribonuclease TATDN2 OS=Homo sapiens OX=9606 GN=TATDN2 PE=1 SV=2" "0.003" "False" "2.920" "2" "2" "2" "2" "761" "85.0" "7.39" "4.86" "2" "" "nucleus" "other molecular function" "Pf01026" "9797" "ENSG00000157014" "TATDN2" "hsa:9797; Q3MIL9; Q5BKU0; Q93075" "" "XBP1(S) activates chaperone genes" "1" "0" "1.250" "1.168" "1.287" "1.197" "1.034" "1.114" "1.141" "1.071" "1.084" "188.0" "235.1" "219.6" "242.0" "225.0" "194.4" "209.5" "214.5" "201.3" "203.9" "" "" "" "" "" "" "" "" "" "" "176.2" "194.6" "203.8" "187.1" "191.8" "185.8" "191.4" "190.4" "201.3" "196.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6764322891151840328" "False" "High" "IsMasterProtein" "P19484" "Transcription factor EB OS=Homo sapiens OX=9606 GN=TFEB PE=1 SV=3" "0.003" "False" "2.919" "2" "1" "1" "1" "476" "52.8" "6.29" "3.56" "1" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf11851, Pf15951" "7942" "ENSG00000112561" "TFEB" "hsa:7942; P19484; Q709B3; Q7Z6P9; Q9BRJ5; Q9UJD8" "PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Type 2 papillary renal cell carcinoma; Autophagy in pancreatic ductal adenocarcinoma" "" "3" "0" "1.038" "0.905" "0.997" "1.006" "1.008" "1.030" "0.873" "0.899" "1.021" "75.4" "78.3" "68.3" "75.2" "75.9" "76.0" "77.7" "65.9" "67.8" "77.0" "" "" "" "" "" "" "" "" "" "" "70.7" "64.8" "63.4" "58.1" "64.7" "72.6" "71.0" "58.5" "67.8" "74.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7054599493317546199" "False" "High" "IsMasterProtein" "Q8TCC3" "Large ribosomal subunit protein uL30m OS=Homo sapiens OX=9606 GN=MRPL30 PE=1 SV=1" "0.003" "False" "2.919" "5" "1" "1" "1" "161" "18.5" "9.99" "2.92" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00327" "51263" "ENSG00000185414" "MRPL30" "A6NIC6; D3DVI0; D3DVI3; hsa:51263; Q0D2Q7; Q6ZTP4; Q8TCC3; Q96Q69; Q9P0N0" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.072" "1.053" "1.048" "1.149" "1.129" "1.050" "1.035" "1.096" "1.086" "265.6" "284.7" "279.7" "278.4" "305.0" "299.8" "278.9" "274.8" "291.0" "288.4" "" "" "" "" "" "" "" "" "" "" "248.9" "235.5" "259.7" "215.2" "260.0" "286.4" "254.8" "244.0" "291.0" "277.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "900299520703075400" "False" "High" "IsMasterProtein" "Q8N4W9" "Zinc finger protein 808 OS=Homo sapiens OX=9606 GN=ZNF808 PE=1 SV=2" "0.003" "False" "2.915" "3" "2" "3" "2" "903" "104.8" "9.48" "4.72" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "388558" "ENSG00000198482" "ZNF808" "hsa:388558; Q68CN7; Q8N4W9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7478830788962877121" "False" "High" "IsMasterProtein" "Q9Y3C4" "EKC/KEOPS complex subunit TPRKB OS=Homo sapiens OX=9606 GN=TPRKB PE=1 SV=1" "0.003" "False" "2.907" "8" "1" "1" "1" "175" "19.6" "6.79" "3.40" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08617" "51002" "ENSG00000144034; ENSG00000291480" "TPRKB" "D6W5H6; hsa:51002; Q8IWR6; Q8IWR7; Q9H3K4; Q9Y3C4" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.034" "1.191" "1.245" "1.286" "1.036" "1.124" "1.095" "1.145" "1.073" "154.5" "159.6" "184.0" "192.3" "198.7" "160.0" "173.6" "169.2" "176.9" "165.8" "" "" "" "" "" "" "" "" "" "" "144.7" "132.1" "170.8" "148.6" "169.4" "152.8" "158.6" "150.2" "176.9" "159.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3757021002134428310" "False" "High" "IsMasterProtein" "Q8TBM8" "DnaJ homolog subfamily B member 14 OS=Homo sapiens OX=9606 GN=DNAJB14 PE=1 SV=1" "0.003" "False" "2.905" "2" "1" "1" "1" "379" "42.5" "8.59" "2.63" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf00226, Pf09320" "79982" "ENSG00000164031" "DNAJB14" "hsa:79982; Q6UXN1; Q7Z3P0; Q86TA7; Q86TM0; Q8TBM8; Q9GZU9" "" "" "0" "0" "1.145" "0.975" "1.180" "1.114" "1.072" "1.213" "1.136" "1.187" "1.117" "196.1" "224.5" "191.2" "231.3" "218.5" "210.2" "237.8" "222.7" "232.8" "219.0" "" "" "" "" "" "" "" "" "" "" "183.7" "185.7" "177.5" "178.8" "186.3" "200.8" "217.3" "197.7" "232.8" "210.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8996103182095070186" "False" "High" "IsMasterProtein" "Q9UBF6" "RING-box protein 2 OS=Homo sapiens OX=9606 GN=RNF7 PE=1 SV=1" "0.003" "False" "2.899" "11" "1" "1" "1" "113" "12.7" "5.44" "0.00" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12678" "9616" "ENSG00000114125" "RNF7" "A8K1H9; A8MTB5; C9JYL3; D3DNF7; D3DNF8; hsa:9616; Q9BXN8; Q9UBF6; Q9Y5M7" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Modulators of TCR signaling and T cell activation" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Inactivation of CSF3 (G-CSF) signaling" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "282539810863181563" "False" "High" "IsMasterProtein" "Q9UL40" "Zinc finger protein 346 OS=Homo sapiens OX=9606 GN=ZNF346 PE=1 SV=1" "0.003" "False" "2.893" "3" "1" "2" "1" "294" "32.9" "9.09" "6.15" "1" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12874" "23567" "ENSG00000113761" "ZNF346" "B7Z367; hsa:23567; Q68CV9; Q6ZMW1; Q9UL40" "5q35 copy number variation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8700335326144916466" "False" "High" "IsMasterProtein" "Q9UET6" "tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase OS=Homo sapiens OX=9606 GN=FTSJ1 PE=1 SV=2" "0.003" "False" "2.882" "3" "1" "1" "1" "329" "36.1" "5.69" "3.75" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01728" "24140" "ENSG00000068438" "FTSJ1" "B2RCJ0; hsa:24140; O75670; Q9UET6" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.999" "0.978" "1.029" "1.027" "0.941" "0.917" "0.963" "0.929" "0.953" "175.7" "175.5" "171.9" "180.9" "180.6" "165.4" "161.2" "169.3" "163.2" "167.5" "" "" "" "" "" "" "" "" "" "" "164.7" "145.3" "159.6" "139.8" "153.9" "158.0" "147.3" "150.3" "163.2" "161.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4402590464263021312" "False" "High" "IsMasterProtein" "Q9Y483" "Metal-response element-binding transcription factor 2 OS=Homo sapiens OX=9606 GN=MTF2 PE=1 SV=3" "0.003" "False" "2.879" "2" "1" "1" "1" "593" "67.0" "8.75" "3.67" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00628, Pf14061, Pf18104" "22823" "ENSG00000143033" "MTF2" "A6NGQ9; A8K2Q3; B1AKT5; B1AKT6; hsa:22823; Q96G26; Q9UES9; Q9UP40; Q9Y483" "Mesodermal commitment pathway; Interactome of polycomb repressive complex 2 (PRC2) ; Copper homeostasis" "PRC2 methylates histones and DNA" "4" "0" "1.046" "1.026" "0.884" "0.955" "1.009" "1.024" "1.105" "1.090" "1.187" "119.4" "125.0" "122.5" "105.6" "114.1" "120.5" "122.3" "132.0" "130.2" "141.8" "" "" "" "" "" "" "" "" "" "" "111.9" "103.4" "113.7" "81.6" "97.2" "115.2" "111.8" "117.2" "130.2" "136.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1874471011183671858" "False" "High" "IsMasterProtein" "Q16670" "Zinc finger and SCAN domain-containing protein 26 OS=Homo sapiens OX=9606 GN=ZSCAN26 PE=1 SV=2" "0.003" "False" "2.876" "2" "1" "1" "1" "478" "55.2" "8.06" "3.07" "1" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf02023" "7741" "ENSG00000197062" "ZSCAN26" "hsa:7741; Q16670; Q5JPG4; Q7Z3Q6; Q96A17" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6751278663907923034" "False" "High" "IsMasterProtein" "Q9UFG5" "UPF0449 protein C19orf25 OS=Homo sapiens OX=9606 GN=C19orf25 PE=1 SV=2" "0.003" "False" "2.874" "7" "1" "1" "1" "118" "12.9" "5.07" "3.08" "1" "" "" "" "Pf15136" "148223" "ENSG00000119559" "C19orf25" "B3KQN6; hsa:148223; Q8N9R7; Q8WV94; Q9UFG5" "" "" "0" "0" "1.028" "1.128" "1.163" "1.114" "1.005" "1.098" "1.035" "1.101" "0.979" "144.7" "148.8" "163.3" "168.2" "161.1" "145.5" "158.9" "149.8" "159.3" "141.7" "" "" "" "" "" "" "" "" "" "" "135.6" "123.1" "151.6" "130.1" "137.4" "139.0" "145.2" "133.0" "159.3" "136.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1314787517679089989" "False" "High" "IsMasterProtein" "Q8WUX9" "Charged multivesicular body protein 7 OS=Homo sapiens OX=9606 GN=CHMP7 PE=1 SV=1" "0.003" "False" "2.873" "2" "1" "2" "1" "453" "50.9" "5.35" "5.13" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf03357" "91782" "ENSG00000147457" "CHMP7" "B2RDT3; B4DKJ6; D3DSS1; hsa:91782; Q8NDM1; Q8WUX9; Q9BT50" "" "Late endosomal microautophagy; Pyroptosis; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4078172975795956139" "False" "High" "IsMasterProtein" "Q7Z6V5" "tRNA-specific adenosine deaminase 2 OS=Homo sapiens OX=9606 GN=ADAT2 PE=1 SV=1" "0.003" "False" "2.872" "4" "1" "1" "1" "191" "21.0" "6.74" "3.30" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf14437" "134637" "ENSG00000189007" "ADAT2" "A6NL12; B3KWY3; hsa:134637; Q7Z327; Q7Z6V5; Q8IY39" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.843" "0.954" "0.805" "0.770" "0.845" "0.867" "0.728" "0.798" "0.866" "311.9" "262.9" "297.6" "250.9" "240.2" "263.4" "270.4" "227.0" "249.0" "270.0" "" "" "" "" "" "" "" "" "" "" "292.2" "217.6" "276.3" "194.0" "204.7" "251.7" "247.1" "201.6" "249.0" "260.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1241863298076822509" "False" "High" "IsMasterProtein" "Q5VUA4" "Zinc finger protein 318 OS=Homo sapiens OX=9606 GN=ZNF318 PE=1 SV=2" "0.003" "False" "2.870" "1" "2" "2" "2" "2279" "251.0" "7.20" "2.25" "2" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "" "24149" "ENSG00000171467" "ZNF318" "hsa:24149; O94796; Q4G0E4; Q5VUA4; Q8NEM6; Q9UNU8; Q9Y2W9" "Androgen receptor signaling pathway" "" "1" "0" "1.017" "0.997" "1.156" "1.020" "0.998" "1.055" "0.966" "1.103" "1.154" "140.8" "143.2" "140.4" "162.8" "143.7" "140.5" "148.5" "136.1" "155.4" "162.5" "" "" "" "" "" "" "" "" "" "" "132.0" "118.5" "130.3" "125.9" "122.5" "134.3" "135.7" "120.8" "155.4" "156.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-958825745261361591" "False" "High" "IsMasterProtein" "Q7Z3J2" "VPS35 endosomal protein-sorting factor-like OS=Homo sapiens OX=9606 GN=VPS35L PE=1 SV=2" "0.003" "False" "2.867" "2" "2" "2" "2" "963" "109.5" "7.21" "2.15" "2" "transport" "plasma membrane;other membranes;other cytoplasmic organelle" "" "" "57020" "ENSG00000103544" "VPS35L" "A8K2M1; hsa:57020; O43329; Q69YI1; Q6PDA0; Q7L371; Q7Z3J2; Q86W66; Q8WXA5; Q9H0L7; Q9H7C8" "" "Neutrophil degranulation" "1" "0" "1.231" "1.041" "1.219" "1.100" "1.055" "1.040" "0.963" "0.915" "1.028" "27.3" "33.6" "28.4" "33.3" "30.1" "28.8" "28.4" "26.3" "25.0" "28.1" "" "" "" "" "" "" "" "" "" "" "25.6" "27.8" "26.4" "25.8" "25.6" "27.6" "26.0" "23.4" "25.0" "27.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2476357386497252081" "False" "High" "IsMasterProtein" "Q07617" "Sperm-associated antigen 1 OS=Homo sapiens OX=9606 GN=SPAG1 PE=1 SV=3" "0.003" "False" "2.866" "1" "1" "1" "1" "926" "103.6" "6.86" "2.12" "1" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00515, Pf13877" "6674" "ENSG00000104450" "SPAG1" "A6NP70; B3KQ58; G3XAM3; hsa:6674; Q07617; Q7Z5G1" "Ciliopathies" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8785162228829611300" "False" "High" "IsMasterProtein" "Q38SD2" "Leucine-rich repeat serine/threonine-protein kinase 1 OS=Homo sapiens OX=9606 GN=LRRK1 PE=1 SV=3" "0.003" "False" "2.859" "1" "1" "1" "1" "2015" "225.2" "6.68" "2.45" "1" "other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00069, Pf00560, Pf08477, Pf16095" "79705" "ENSG00000154237" "LRRK1" "Q38SD2; Q6NVH5; Q6NYC0; Q6ZNL9; Q6ZNM9; Q96JN5; Q9H5S3" "" "" "0" "0" "1.077" "1.028" "1.405" "1.057" "1.156" "1.149" "1.036" "1.084" "1.099" "57.8" "62.3" "59.5" "81.2" "61.2" "66.8" "66.5" "59.9" "62.7" "63.6" "" "" "" "" "" "" "" "" "" "" "54.2" "51.5" "55.2" "62.8" "52.1" "63.9" "60.7" "53.2" "62.7" "61.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8329902597412157938" "False" "High" "IsMasterProtein" "Q15048" "Leucine-rich repeat-containing protein 14 OS=Homo sapiens OX=9606 GN=LRRC14 PE=1 SV=1" "0.003" "False" "2.858" "2" "1" "1" "1" "493" "54.5" "6.90" "3.63" "1" "other biological processes" "cytosol;other cell component" "other molecular function" "Pf13516" "9684" "ENSG00000160959" "LRRC14" "A8K0A8; D3DWM8; hsa:9684; Q15048" "" "Regulation of NF-kappa B signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6773616667088229623" "False" "High" "IsMasterProtein" "Q8N4Q0" "Prostaglandin reductase 3 OS=Homo sapiens OX=9606 GN=PTGR3 PE=1 SV=1" "0.003" "False" "2.855" "2" "1" "1" "1" "377" "40.1" "8.18" "2.96" "1" "other metabolic processes;other biological processes" "other cytoplasmic organelle" "other molecular function" "Pf00107, Pf08240" "284273" "ENSG00000180011" "PTGR3" "A8KA15; B4DZ91; hsa:284273; Q8N4Q0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-946118222351064345" "False" "High" "IsMasterProtein" "Q6DD87" "Zinc finger protein 787 OS=Homo sapiens OX=9606 GN=ZNF787 PE=1 SV=4" "0.003" "False" "2.855" "3" "1" "2" "1" "382" "40.4" "7.96" "7.19" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13465, Pf13912" "126208" "ENSG00000142409" "ZNF787" "A0A087WUD1; hsa:126208; O00455; Q6DD87" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8613494787005004283" "False" "High" "IsMasterProtein" "Q9BWJ5" "Splicing factor 3B subunit 5 OS=Homo sapiens OX=9606 GN=SF3B5 PE=1 SV=1" "0.003" "False" "2.854" "13" "1" "1" "1" "86" "10.1" "6.35" "2.71" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07189" "83443" "ENSG00000169976" "SF3B5" "B2R568; hsa:83443; Q7RTV1; Q9BWJ5" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8787657634019778386" "False" "High" "IsMasterProtein" "Q2TAA2" "Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Homo sapiens OX=9606 GN=IAH1 PE=1 SV=1" "0.003" "False" "2.853" "3" "1" "1" "1" "248" "27.6" "5.30" "3.60" "1" "other metabolic processes" "" "other molecular function" "Pf00657" "285148" "ENSG00000134330" "IAH1" "B4DMV3; hsa:285148; Q2TAA2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2576467063852337379" "False" "High" "IsMasterProtein" "Q12912" "Inositol 1,4,5-triphosphate receptor associated 2 OS=Homo sapiens OX=9606 GN=IRAG2 PE=1 SV=3" "0.003" "False" "2.852" "3" "2" "2" "2" "555" "62.1" "5.85" "5.16" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf05781" "4033" "ENSG00000118308" "IRAG2" "A0AVM2; B4E077; hsa:4033; Q12912; Q8N301" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6720179589779934486" "False" "High" "IsMasterProtein" "O96007" "Molybdopterin synthase catalytic subunit OS=Homo sapiens OX=9606 GN=MOCS2 PE=1 SV=1" "0.003" "False" "2.852" "5" "1" "1" "1" "188" "20.9" "5.44" "2.95" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02391" "4338" "ENSG00000164172" "MOCS2" "hsa:4338; O96007; Q6IAI3" "Metabolic Epileptic Disorders" "Molybdenum cofactor biosynthesis" "2" "0" "1.031" "1.053" "1.090" "1.111" "1.084" "1.099" "1.064" "1.145" "1.191" "223.8" "230.8" "235.6" "243.9" "248.6" "242.6" "246.0" "238.1" "256.2" "266.6" "" "" "" "" "" "" "" "" "" "" "209.7" "190.9" "218.8" "188.6" "211.9" "231.8" "224.8" "211.4" "256.2" "256.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1435707363815542229" "False" "High" "IsMasterProtein" "Q9ULG1" "Chromatin-remodeling ATPase INO80 OS=Homo sapiens OX=9606 GN=INO80 PE=1 SV=2" "0.003" "False" "2.848" "1" "1" "1" "1" "1556" "176.6" "9.50" "2.51" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf13892" "54617" "ENSG00000128908" "INO80" "A6H8X4; hsa:54617; Q9NTG6; Q9ULG1" "" "DNA Damage Recognition in GG-NER; UCH proteinases" "2" "0" "0.958" "0.991" "0.931" "1.004" "1.049" "1.019" "1.072" "0.940" "1.014" "110.3" "105.7" "109.3" "102.7" "110.8" "115.7" "112.5" "118.3" "103.7" "111.9" "" "" "" "" "" "" "" "" "" "" "103.4" "87.5" "101.5" "79.4" "94.5" "110.5" "102.8" "105.0" "103.7" "107.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7092203840537422640" "False" "High" "IsMasterProtein" "Q8NBZ0" "INO80 complex subunit E OS=Homo sapiens OX=9606 GN=INO80E PE=1 SV=1" "0.003" "False" "2.842" "3" "1" "1" "1" "244" "26.5" "8.34" "2.98" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "" "" "283899" "ENSG00000169592" "INO80E" "hsa:283899; Q6Y2K3; Q8NBZ0" "16p11.2 proximal deletion syndrome" "UCH proteinases; DNA Damage Recognition in GG-NER" "3" "0" "0.966" "1.041" "1.015" "1.169" "1.017" "0.990" "1.031" "0.975" "1.014" "214.8" "207.5" "223.5" "218.0" "251.0" "218.5" "212.6" "221.5" "209.3" "217.7" "" "" "" "" "" "" "" "" "" "" "201.3" "171.7" "207.5" "168.5" "214.0" "208.8" "194.3" "196.6" "209.3" "209.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4126622846664947622" "False" "High" "IsMasterProtein" "Q96H35" "Probable RNA-binding protein 18 OS=Homo sapiens OX=9606 GN=RBM18 PE=1 SV=1" "0.003" "False" "2.840" "5" "1" "1" "1" "190" "21.6" "9.44" "2.86" "1" "" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "92400" "ENSG00000119446" "RBM18" "B3KQ89; hsa:92400; Q96H35" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4762125104752177783" "False" "High" "IsMasterProtein" "A0JNW5" "Bridge-like lipid transfer protein family member 3B OS=Homo sapiens OX=9606 GN=BLTP3B PE=1 SV=2" "0.003" "False" "2.839" "1" "1" "1" "1" "1464" "164.1" "6.32" "2.92" "1" "cell organization and biogenesis;transport" "cytosol;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf12624" "23074" "ENSG00000111647" "BLTP3B" "A0JNW5; A0PJE5; hsa:23074; O75183; Q8NDL1; Q96C30; Q9BTS5; Q9H0F1" "" "RND2 GTPase cycle" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3081851764267628818" "False" "High" "IsMasterProtein" "Q9Y2P8" "RNA 3'-terminal phosphate cyclase-like protein OS=Homo sapiens OX=9606 GN=RCL1 PE=1 SV=3" "0.003" "False" "2.838" "2" "1" "1" "1" "373" "40.8" "9.26" "2.72" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01137, Pf05189" "10171" "ENSG00000120158" "RCL1" "D3DRI2; hsa:10171; Q5VYW9; Q5VZU1; Q9H9D0; Q9NY00; Q9P044; Q9Y2P8" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5838034404829908083" "False" "High" "IsMasterProtein" "Q5FWF4" "DNA annealing helicase and endonuclease ZRANB3 OS=Homo sapiens OX=9606 GN=ZRANB3 PE=1 SV=2" "0.003" "False" "2.836" "1" "1" "1" "1" "1079" "123.2" "8.44" "0.00" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00641, Pf01844" "84083" "ENSG00000121988" "ZRANB3" "B3KYA1; B4E375; B5MDI3; D3DP76; E9PBP0; hsa:84083; Q53SM1; Q5FWF4; Q6P2C4; Q8N1P4; Q9H0E8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2290634973285225426" "False" "High" "IsMasterProtein" "Q7Z589" "BRCA2-interacting transcriptional repressor EMSY OS=Homo sapiens OX=9606 GN=EMSY PE=1 SV=2" "0.003" "False" "2.833" "1" "1" "1" "1" "1322" "141.4" "9.33" "3.02" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf03735" "56946" "ENSG00000158636" "EMSY" "B7ZKT8; B7ZKU0; B7ZKU2; hsa:56946; Q17RM7; Q4G109; Q7Z589; Q8NBU6; Q8TE50; Q9H8I9; Q9NRH0" "Mesodermal commitment pathway" "" "1" "0" "1.060" "1.066" "1.118" "1.044" "1.021" "1.080" "1.025" "0.991" "1.021" "302.1" "320.2" "322.0" "337.6" "315.4" "308.4" "326.2" "309.7" "299.5" "308.6" "" "" "" "" "" "" "" "" "" "" "283.1" "264.9" "298.9" "261.0" "268.8" "294.6" "298.1" "275.0" "299.5" "297.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1217035742207270021" "False" "High" "IsMasterProtein" "Q17RN3" "Protein FAM98C OS=Homo sapiens OX=9606 GN=FAM98C PE=1 SV=1" "0.003" "False" "2.822" "5" "2" "2" "2" "349" "37.3" "7.18" "4.35" "2" "" "other cell component" "" "Pf10239" "147965" "ENSG00000130244" "FAM98C" "A6NMW3; hsa:147965; Q17RN3; Q66K45" "" "" "0" "0" "1.043" "1.127" "1.072" "1.117" "1.015" "1.032" "0.967" "1.010" "1.000" "325.9" "339.9" "367.2" "349.4" "364.2" "330.8" "336.5" "315.3" "329.2" "326.0" "" "" "" "" "" "" "" "" "" "" "305.4" "281.2" "340.9" "270.1" "310.4" "316.1" "307.5" "279.9" "329.2" "313.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3531343313582380268" "False" "High" "IsMasterProtein" "P42338" "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PIK3CB PE=1 SV=1" "0.003" "False" "2.821" "1" "1" "1" "1" "1070" "122.7" "7.09" "2.48" "1" "cell adhesion;cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792, Pf00794, Pf02192" "5291" "ENSG00000051382" "PIK3CB" "D3DNF0; hsa:5291; P42338; Q24JU2" "AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; Focal adhesion; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Pancreatic adenocarcinoma pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; G13 signaling pathway; Acute myeloid leukemia; ErbB signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "Downstream TCR signaling; Nephrin family interactions; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; PIP3 activates AKT signaling; Signaling by ALK fusions and activated point mutants; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; RAF/MAP kinase cascade; PI3K Cascade; GPVI-mediated activation cascade; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; VEGFA-VEGFR2 Pathway; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Signaling by CSF1 (M-CSF) in myeloid cells" "74" "0" "0.982" "0.914" "1.057" "0.969" "0.943" "1.026" "0.943" "0.957" "0.979" "237.2" "232.8" "216.8" "250.7" "229.9" "223.6" "243.4" "223.6" "227.0" "232.2" "" "" "" "" "" "" "" "" "" "" "222.2" "192.7" "201.2" "193.8" "195.9" "213.7" "222.4" "198.6" "227.0" "223.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7769023371860008745" "False" "High" "IsMasterProtein" "Q8N5I2" "Arrestin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ARRDC1 PE=1 SV=1" "0.003" "False" "2.818" "3" "1" "1" "1" "433" "46.0" "7.02" "2.03" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf00339, Pf02752" "92714" "ENSG00000197070" "ARRDC1" "hsa:92714; Q8N5I2" "" "" "0" "0" "1.025" "0.954" "1.008" "0.967" "0.981" "0.933" "1.015" "1.086" "0.979" "93.1" "95.4" "88.8" "93.9" "90.1" "91.4" "86.9" "94.6" "101.2" "91.2" "" "" "" "" "" "" "" "" "" "" "87.2" "79.0" "82.5" "72.6" "76.8" "87.3" "79.4" "84.0" "101.2" "87.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6289103138971436577" "False" "High" "IsMasterProtein" "Q92520" "Protein FAM3C OS=Homo sapiens OX=9606 GN=FAM3C PE=1 SV=1" "0.003" "False" "2.818" "4" "1" "1" "1" "227" "24.7" "8.29" "2.52" "1" "signal transduction" "non-structural extracellular;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf15711" "10447" "ENSG00000196937" "FAM3C" "A6NDN2; A8K3R7; hsa:10447; Q92520" "" "Platelet degranulation" "1" "0" "0.987" "1.007" "1.039" "0.926" "0.991" "1.071" "1.090" "1.083" "1.024" "268.9" "265.3" "270.8" "279.5" "248.9" "266.5" "287.9" "293.1" "291.1" "275.5" "" "" "" "" "" "" "" "" "" "" "251.9" "219.6" "251.4" "216.1" "212.2" "254.6" "263.1" "260.3" "291.1" "265.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6391839617332390225" "False" "High" "IsMasterProtein" "P07203" "Glutathione peroxidase 1 OS=Homo sapiens OX=9606 GN=GPX1 PE=1 SV=4" "0.003" "False" "2.818" "5" "1" "1" "1" "203" "22.1" "6.55" "3.70" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00255" "2876" "ENSG00000233276" "GPX1" "E9PAS1; hsa:2876; P07203; Q7Z5H1; Q9BW12" "Glutathione metabolism; Selenium micronutrient network; Folate metabolism; Amyotrophic lateral sclerosis (ALS); Trans-sulfuration, one-carbon metabolism and related pathways; Selenium metabolism and selenoproteins; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; One-carbon metabolism and related pathways; TYROBP causal network in microglia; Oxidative stress response; Male infertility; p53 transcriptional gene network; Omega-6-fatty acids in senescence" "Detoxification of Reactive Oxygen Species; Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 5-eicosatetraenoic acids" "18" "0" "0.935" "0.953" "1.076" "0.960" "1.006" "1.152" "0.943" "0.861" "0.946" "123.9" "115.9" "118.1" "133.3" "118.9" "124.6" "142.7" "116.8" "106.7" "117.2" "" "" "" "" "" "" "" "" "" "" "116.1" "95.9" "109.7" "103.1" "101.4" "119.1" "130.4" "103.7" "106.7" "112.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8867340794532680383" "False" "High" "IsMasterProtein" "O94967" "WD repeat-containing protein 47 OS=Homo sapiens OX=9606 GN=WDR47 PE=1 SV=1" "0.003" "False" "2.816" "1" "1" "1" "1" "919" "101.9" "5.94" "2.43" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;other cell component" "" "Pf00400, Pf17814" "22911" "ENSG00000085433" "WDR47" "A8MX09; hsa:22911; O94967; Q5TYV7; Q5TYV8; Q5TYV9; Q8IXT7; Q8IYU9" "" "" "0" "0" "1.061" "0.978" "1.299" "1.115" "0.898" "1.231" "1.064" "1.012" "1.084" "191.5" "203.2" "187.3" "248.7" "213.6" "172.0" "235.8" "203.7" "193.8" "207.6" "" "" "" "" "" "" "" "" "" "" "179.5" "168.1" "173.9" "192.3" "182.0" "164.3" "215.5" "180.9" "193.8" "199.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8504689738561094897" "False" "High" "IsMasterProtein" "O43303" "Centriolar coiled-coil protein of 110 kDa OS=Homo sapiens OX=9606 GN=CCP110 PE=1 SV=3" "0.003" "False" "2.812" "1" "1" "1" "1" "1012" "113.4" "8.65" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf16025" "9738" "ENSG00000103540" "CCP110" "B7WP23; hsa:9738; O43303; O43335; Q68DV9; Q8NE13" "Joubert syndrome" "Ub-specific processing proteases; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; RHOV GTPase cycle" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1741597562117516828" "False" "High" "IsMasterProtein" "Q16665" "Hypoxia-inducible factor 1-alpha OS=Homo sapiens OX=9606 GN=HIF1A PE=1 SV=1" "0.004" "False" "2.804" "1" "1" "1" "1" "826" "92.6" "5.33" "3.47" "1" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00989, Pf08447, Pf08778, Pf11413" "3091" "ENSG00000100644" "HIF1A" "C0LZJ3; hsa:3091; Q16665; Q53XP6; Q96PT9; Q9UPB1" "Angiogenesis; AGE/RAGE pathway; Adipogenesis; Oncostatin M signaling pathway; HIF1A and PPARG regulation of glycolysis; Vitamin D receptor pathway; MicroRNA for targeting cancer growth and vascularization in glioblastoma; Photodynamic therapy-induced HIF-1 survival signaling; NAD metabolism, sirtuins and aging; Hepatitis C and hepatocellular carcinoma; lncRNA-mediated mechanisms of therapeutic resistance; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; Hereditary leiomyomatosis and renal cell carcinoma pathway; Epithelial to mesenchymal transition in colorectal cancer; Type 2 papillary renal cell carcinoma; Neovascularization processes; 3q29 copy number variation syndrome; Angiotensin II receptor type 1 pathway; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Congenital generalized lipodystrophy; Network map of SARS-CoV-2 signaling pathway; Th17 cell differentiation pathway; GDNF signaling; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Warburg effect modulated by deubiquitinating enzymes and their substrates; Osteoarthritic chondrocyte hypertrophy; HDAC6 interactions in the central nervous system; Notch signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "Neddylation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Ub-specific processing proteases; Circadian Clock; Interleukin-4 and Interleukin-13 signaling; NOTCH1 Intracellular Domain Regulates Transcription; STAT3 nuclear events downstream of ALK signaling; PTK6 promotes HIF1A stabilization; Regulation of gene expression by Hypoxia-inducible Factor; PTK6 Expression" "43" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-60388765585118576" "False" "High" "IsMasterProtein" "Q9H875" "PRKR-interacting protein 1 OS=Homo sapiens OX=9606 GN=PRKRIP1 PE=1 SV=1" "0.004" "False" "2.803" "8" "2" "2" "2" "184" "21.0" "9.79" "6.37" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf06658" "79706" "ENSG00000128563" "PRKRIP1" "B4DGM2; hsa:79706; Q8NDM6; Q96CF8; Q9H875" "" "mRNA Splicing - Major Pathway" "1" "0" "1.043" "0.944" "0.996" "1.087" "1.051" "1.052" "1.118" "1.116" "1.078" "650.8" "679.1" "614.7" "648.1" "707.3" "683.8" "685.0" "727.7" "726.1" "701.6" "" "" "" "" "" "" "" "" "" "" "609.8" "561.9" "570.7" "501.0" "602.9" "653.3" "625.9" "646.1" "726.1" "675.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2529735565303520700" "False" "High" "IsMasterProtein" "Q9BQS8" "FYVE and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FYCO1 PE=1 SV=3" "0.004" "False" "2.795" "1" "1" "1" "1" "1478" "166.9" "4.92" "2.31" "1" "transport;other biological processes" "ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf02759" "79443" "ENSG00000163820" "FYCO1" "B7ZKT7; hsa:79443; Q3MJE6; Q86T41; Q86TB1; Q8TEF9; Q96IV5; Q9BQS8; Q9H8P9" "Clock-controlled autophagy in bone metabolism" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3299789878161975877" "False" "High" "IsMasterProtein" "Q76L83" "Putative Polycomb group protein ASXL2 OS=Homo sapiens OX=9606 GN=ASXL2 PE=1 SV=1" "0.004" "False" "2.795" "1" "1" "1" "1" "1435" "153.7" "8.81" "2.31" "1" "other biological processes" "nucleus" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf05066, Pf13919, Pf13922" "55252" "ENSG00000143970" "ASXL2" "hsa:55252; Q53TC9; Q5H9U4; Q76L81; Q76L83; Q86XM1; Q9C0H8; Q9NV67" "" "UCH proteinases" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5057287332675180047" "False" "High" "IsMasterProtein" "P25963" "NF-kappa-B inhibitor alpha OS=Homo sapiens OX=9606 GN=NFKBIA PE=1 SV=1" "0.004" "False" "2.793" "3" "1" "1" "1" "317" "35.6" "4.68" "2.83" "1" "stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00023" "4792" "ENSG00000100906" "NFKBIA" "B2R8L6; hsa:4792; P25963" "Nucleotide-binding oligomerization domain (NOD) pathway; IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; Apoptosis; Ebstein-Barr virus LMP1 signaling; RAC1/PAK1/p38/MMP2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; NO/cGMP/PKG mediated neuroprotection; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Burn wound healing; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Th17 cell differentiation pathway; GDNF signaling; 2q37 copy number variation syndrome; Comprehensive IL-17A signaling; IL-26 signaling pathways; Affected pathways in Duchenne muscular dystrophy; T-cell receptor signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; RIP-mediated NFkB activation via ZBP1; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; SARS-CoV-1 activates/modulates innate immune responses; SUMOylation of immune response proteins" "63" "0" "1.028" "0.953" "1.039" "0.992" "0.945" "0.932" "0.880" "0.880" "0.912" "387.2" "398.0" "369.1" "402.2" "383.9" "365.9" "361.0" "340.6" "340.9" "353.1" "" "" "" "" "" "" "" "" "" "" "362.8" "329.3" "342.7" "310.9" "327.2" "349.6" "329.9" "302.4" "340.9" "340.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-580197304848334652" "False" "High" "IsMasterProtein" "Q13496" "Myotubularin OS=Homo sapiens OX=9606 GN=MTM1 PE=1 SV=2" "0.004" "False" "2.793" "1" "1" "1" "1" "603" "69.9" "8.18" "3.13" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02893, Pf06602" "4534" "ENSG00000171100" "MTM1" "A6NDB1; B7Z491; F2Z330; hsa:4534; Q13496; Q8NEL1" "" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "3" "0" "1.035" "1.053" "1.138" "1.079" "1.092" "1.068" "1.092" "1.185" "1.145" "161.7" "167.4" "170.3" "184.0" "174.5" "176.6" "172.7" "176.6" "191.6" "185.2" "" "" "" "" "" "" "" "" "" "" "151.5" "138.5" "158.1" "142.2" "148.8" "168.7" "157.8" "156.8" "191.6" "178.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5131911605729766219" "False" "High" "IsMasterProtein" "O60516" "Eukaryotic translation initiation factor 4E-binding protein 3 OS=Homo sapiens OX=9606 GN=EIF4EBP3 PE=1 SV=1" "0.004" "False" "2.791" "18" "1" "1" "1" "100" "10.9" "4.48" "2.20" "1" "other biological processes" "translational apparatus;nucleus;other cell component" "other molecular function" "Pf05456" "8637" "ENSG00000243056" "EIF4EBP3" "hsa:8637; O60516" "Translation factors" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5562352938997933923" "False" "High" "IsMasterProtein" "P24278" "Zinc finger and BTB domain-containing protein 25 OS=Homo sapiens OX=9606 GN=ZBTB25 PE=1 SV=2" "0.004" "False" "2.791" "3" "1" "1" "1" "435" "49.0" "6.55" "2.56" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "7597" "ENSG00000089775" "ZBTB25" "B3KUX6; hsa:7597; P24278; Q8IYH9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4224982315492592647" "False" "High" "IsMasterProtein" "A6NIE6" "Putative RRN3-like protein RRN3P2 OS=Homo sapiens OX=9606 GN=RRN3P2 PE=5 SV=3" "0.004" "False" "2.784" "4" "1" "1" "1" "340" "38.0" "5.17" "1.97" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf05327" "" "" "RRN3P2" "A6NIE6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5377279648093334159" "False" "High" "IsMasterProtein" "Q9UEE5" "Serine/threonine-protein kinase 17A OS=Homo sapiens OX=9606 GN=STK17A PE=1 SV=2" "0.004" "False" "2.783" "2" "1" "1" "1" "414" "46.5" "5.15" "3.01" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus" "kinase activity;other molecular function" "Pf00069" "9263" "ENSG00000164543" "STK17A" "A4D1V6; hsa:9263; Q8IVC8; Q9UEE5" "" "" "0" "0" "1.146" "1.085" "1.154" "1.069" "0.904" "0.902" "0.947" "0.950" "0.988" "144.0" "165.0" "156.2" "166.2" "154.0" "130.2" "129.8" "136.4" "136.9" "142.3" "" "" "" "" "" "" "" "" "" "" "135.0" "136.5" "145.0" "128.5" "131.2" "124.4" "118.6" "121.1" "136.9" "137.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2179808201318642480" "False" "High" "IsMasterProtein" "Cont_Q3SZR3" "Alpha-1-acid glycoprotein OS=Bos taurus OX=9913 GN=ORM1 PE=2 SV=1" "0.004" "True" "2.782" "4" "1" "1" "1" "202" "23.2" "5.87" "3.89" "1" "stress response;other biological processes" "non-structural extracellular" "" "Pf00061" "497200" "" "ORM1" "bta:497200; Q3SZR3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7261196343921224419" "False" "High" "IsMasterProtein" "Q96P20" "NACHT, LRR and PYD domains-containing protein 3 OS=Homo sapiens OX=9606 GN=NLRP3 PE=1 SV=3" "0.004" "False" "2.782" "1" "1" "1" "1" "1036" "118.1" "6.65" "2.97" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf02758, Pf05729, Pf13516, Pf14484, Pf17776, Pf17779" "114548" "" "NLRP3" "A0A024R5Q0; B2RC97; B7ZKS9; B7ZKT2; B7ZKT3; hsa:114548; O75434; Q17RS2; Q59H68; Q5JQS8; Q5JQS9; Q6TG35; Q8TCW0; Q8TEU9; Q8WXH9; Q96P20" "IL1 and megakaryocytes in obesity" "Cytoprotection by HMOX1; SARS-CoV-2 activates/modulates innate and adaptive immune responses; SARS-CoV-1 activates/modulates innate immune responses; Metalloprotease DUBs; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4045891090085866349" "False" "High" "IsMasterProtein" "Q6N063" "2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=OGFOD2 PE=1 SV=2" "0.004" "False" "2.781" "2" "1" "1" "1" "350" "39.0" "5.68" "3.41" "1" "" "" "other molecular function" "" "79676" "ENSG00000111325" "OGFOD2" "B3KT24; hsa:79676; Q4KN13; Q6N023; Q6N063; Q9H8K6" "" "" "0" "0" "0.916" "0.956" "1.023" "1.043" "1.107" "1.013" "1.065" "1.024" "1.061" "267.5" "244.9" "255.7" "273.6" "278.9" "296.2" "271.1" "284.9" "273.8" "283.8" "" "" "" "" "" "" "" "" "" "" "250.6" "202.6" "237.4" "211.5" "237.7" "283.0" "247.7" "252.9" "273.8" "273.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824788000835968644" "False" "High" "IsMasterProtein" "O15182" "Centrin-3 OS=Homo sapiens OX=9606 GN=CETN3 PE=1 SV=2" "0.004" "False" "2.780" "5" "1" "1" "1" "167" "19.5" "4.74" "3.01" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf13499" "1070" "ENSG00000153140" "CETN3" "hsa:1070; O15182; Q53YD2; Q9BS23" "Breast cancer pathway" "" "1" "0" "1.150" "1.026" "0.946" "1.059" "1.080" "0.995" "0.969" "0.964" "1.093" "225.7" "259.6" "231.7" "213.5" "239.2" "243.8" "224.6" "218.8" "217.6" "246.8" "" "" "" "" "" "" "" "" "" "" "211.5" "214.8" "215.1" "165.1" "203.9" "232.9" "205.2" "194.3" "217.6" "237.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5107037615117632570" "False" "High" "IsMasterProtein" "P07992" "DNA excision repair protein ERCC-1 OS=Homo sapiens OX=9606 GN=ERCC1 PE=1 SV=1" "0.004" "False" "2.779" "3" "1" "1" "1" "297" "32.5" "6.25" "2.67" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00633, Pf03834" "2067" "ENSG00000012061" "ERCC1" "B2RC01; B3KRR0; hsa:2067; P07992; Q7Z7F5; Q96S40" "Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Fanconi Anemia Pathway; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "9" "0" "0.985" "0.969" "0.940" "0.929" "0.987" "0.973" "0.966" "1.007" "1.010" "207.3" "204.3" "200.9" "195.0" "192.6" "204.7" "201.7" "200.2" "208.7" "209.4" "" "" "" "" "" "" "" "" "" "" "194.3" "169.1" "186.5" "150.7" "164.2" "195.5" "184.3" "177.8" "208.7" "201.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1200249932545446703" "False" "High" "IsMasterProtein" "Q6ZN55" "Zinc finger protein 574 OS=Homo sapiens OX=9606 GN=ZNF574 PE=1 SV=2" "0.004" "False" "2.778" "1" "1" "1" "1" "896" "98.8" "8.07" "3.08" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf12874, Pf13912" "64763" "ENSG00000105732" "ZNF574" "hsa:64763; Q6IPE0; Q6ZN10; Q6ZN55; Q7L5Z5; Q8NCE3; Q9H6N0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "795128292940512142" "False" "High" "IsMasterProtein" "Q96IU2" "Zinc finger BED domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZBED3 PE=1 SV=1" "0.004" "False" "2.772" "6" "2" "2" "2" "234" "25.1" "8.31" "4.78" "2" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf02892" "84327" "ENSG00000132846" "ZBED3" "hsa:84327; Q96IU2" "" "" "0" "0" "0.975" "1.078" "1.037" "1.050" "1.019" "1.049" "0.913" "0.917" "0.935" "218.9" "213.4" "236.0" "227.0" "229.9" "222.9" "229.6" "199.8" "200.6" "204.6" "" "" "" "" "" "" "" "" "" "" "205.1" "176.6" "219.1" "175.5" "196.0" "213.0" "209.8" "177.4" "200.6" "197.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6256207077144686062" "False" "High" "IsMasterProtein" "Q9UK61" "Protein TASOR OS=Homo sapiens OX=9606 GN=TASOR PE=1 SV=3" "0.004" "False" "2.771" "1" "1" "1" "1" "1670" "188.9" "5.80" "2.36" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12509" "23272" "ENSG00000163946" "TASOR" "A1L3A4; B5ME28; hsa:23272; Q9H2F7; Q9UK61; Q9UPP7" "" "" "0" "0" "1.353" "0.982" "1.328" "1.287" "1.072" "1.328" "1.313" "1.434" "1.064" "59.2" "80.1" "58.2" "78.6" "76.2" "63.5" "78.7" "77.8" "84.9" "63.0" "" "" "" "" "" "" "" "" "" "" "55.5" "66.3" "54.0" "60.8" "65.0" "60.7" "71.9" "69.0" "84.9" "60.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8116747825737560157" "False" "High" "IsMasterProtein" "O15235" "Small ribosomal subunit protein uS12m OS=Homo sapiens OX=9606 GN=MRPS12 PE=1 SV=1" "0.004" "False" "2.770" "6" "1" "1" "1" "138" "15.2" "10.29" "3.04" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00164" "6183" "ENSG00000128626; ENSG00000283018" "MRPS12" "hsa:6183; O15235; Q53X98" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8714366505281620526" "False" "High" "IsMasterProtein" "Q7L5Y9" "E3 ubiquitin-protein transferase MAEA OS=Homo sapiens OX=9606 GN=MAEA PE=1 SV=1" "0.004" "False" "2.768" "2" "1" "1" "1" "396" "45.3" "8.69" "3.13" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10607" "10296" "ENSG00000090316" "MAEA" "hsa:10296; O95285; Q5JB54; Q6ZRD6; Q7L5Y9; Q9BQ11; Q9H9V6; Q9H9Z4; Q9NW84" "Ciliary landscape" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3344595424207440426" "False" "High" "IsMasterProtein" "Q96RT8" "Gamma-tubulin complex component 5 OS=Homo sapiens OX=9606 GN=TUBGCP5 PE=1 SV=1" "0.004" "False" "2.768" "1" "2" "2" "2" "1024" "118.2" "5.90" "4.40" "2" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf04130, Pf17681" "114791" "ENSG00000275835" "TUBGCP5" "E9PB12; hsa:114791; Q6IQ52; Q96PY8; Q96RT8" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6229866583710047273" "False" "High" "IsMasterProtein" "Q96C23" "Galactose mutarotase OS=Homo sapiens OX=9606 GN=GALM PE=1 SV=1" "0.004" "False" "2.764" "3" "1" "1" "1" "342" "37.7" "6.65" "3.08" "1" "other metabolic processes" "other cell component" "other molecular function" "Pf01263" "130589" "ENSG00000143891" "GALM" "hsa:130589; Q53RY1; Q8NIA2; Q96C23; V9HWA8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-383335111069342987" "False" "High" "IsMasterProtein" "Q6PD74" "Alpha- and gamma-adaptin-binding protein p34 OS=Homo sapiens OX=9606 GN=AAGAB PE=1 SV=1" "0.004" "False" "2.762" "3" "1" "1" "1" "315" "34.6" "4.64" "2.81" "1" "transport" "cytosol;nucleus;other cell component" "" "Pf10199" "79719" "ENSG00000103591" "AAGAB" "B4DG44; hsa:79719; Q6FI86; Q6PD74; Q7Z5X9; Q9H0P1; Q9HAK0" "" "" "0" "0" "1.111" "1.160" "1.079" "1.087" "0.991" "0.969" "0.885" "1.017" "1.088" "61.6" "68.4" "71.4" "66.5" "66.9" "61.0" "59.7" "54.5" "62.6" "67.0" "" "" "" "" "" "" "" "" "" "" "57.7" "56.6" "66.3" "51.4" "57.0" "58.3" "54.5" "48.4" "62.6" "64.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8657126207816692356" "False" "High" "IsMasterProtein" "O43422" "52 kDa repressor of the inhibitor of the protein kinase OS=Homo sapiens OX=9606 GN=THAP12 PE=1 SV=2" "0.004" "False" "2.754" "1" "1" "1" "1" "761" "87.6" "5.86" "3.01" "1" "signal transduction;other biological processes" "" "nucleic acid binding activity;other molecular function" "Pf05485, Pf05699, Pf14291" "5612" "ENSG00000137492" "THAP12" "A8K728; hsa:5612; O43422; Q17RY9; Q8WTW1; Q9Y3Z4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1624029487017367107" "False" "High" "IsMasterProtein" "Q9C005" "Protein dpy-30 homolog OS=Homo sapiens OX=9606 GN=DPY30 PE=1 SV=1" "0.004" "False" "2.752" "9" "1" "2" "1" "99" "11.2" "4.88" "3.46" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport" "ER/Golgi;nucleus" "other molecular function" "Pf05186" "84661" "ENSG00000162961" "DPY30" "D6W578; hsa:84661; Q9C005" "Kleefstra syndrome" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Formation of WDR5-containing histone-modifying complexes" "5" "0" "1.003" "0.919" "0.887" "0.865" "0.887" "0.862" "0.876" "0.847" "0.867" "283.0" "283.9" "260.1" "251.0" "244.9" "251.1" "244.0" "247.9" "239.6" "245.3" "" "" "" "" "" "" "" "" "" "" "265.2" "235.0" "241.5" "194.0" "208.8" "239.9" "223.0" "220.1" "239.6" "236.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "357357949464127480" "False" "High" "IsMasterProtein" "O75503" "Bis(monoacylglycero)phosphate synthase CLN5 OS=Homo sapiens OX=9606 GN=CLN5 PE=1 SV=2" "0.004" "False" "2.748" "3" "1" "1" "1" "358" "41.5" "7.40" "2.39" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15014" "1203" "ENSG00000102805" "CLN5" "B3KQK7; hsa:1203; O75503" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7551679411334968012" "False" "High" "IsMasterProtein" "Q15649" "Zinc finger HIT domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZNHIT3 PE=1 SV=2" "0.004" "False" "2.747" "6" "1" "1" "1" "155" "17.6" "5.67" "3.21" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04438, Pf21373" "9326" "ENSG00000273611; ENSG00000278574" "ZNHIT3" "A8K493; hsa:9326; K7EQP1; Q15649; Q8WVJ3" "17q12 copy number variation syndrome" "" "1" "0" "1.109" "1.047" "1.009" "1.034" "1.071" "1.063" "0.981" "1.004" "1.080" "217.5" "241.2" "227.7" "219.4" "224.9" "233.1" "231.1" "213.4" "218.4" "235.0" "" "" "" "" "" "" "" "" "" "" "203.8" "199.6" "211.4" "169.6" "191.7" "222.7" "211.2" "189.4" "218.4" "226.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7125243051286610373" "False" "High" "IsMasterProtein" "Q96SN8" "CDK5 regulatory subunit-associated protein 2 OS=Homo sapiens OX=9606 GN=CDK5RAP2 PE=1 SV=5" "0.004" "False" "2.743" "0" "1" "1" "1" "1893" "214.9" "5.58" "2.58" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf07989" "55755" "ENSG00000136861" "CDK5RAP2" "hsa:55755; Q5JV18; Q7Z3L4; Q7Z3U1; Q7Z7I6; Q96SN8; Q9BSW0; Q9H6J6; Q9HCD9; Q9NV90; Q9UIW9" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3880640369393119703" "False" "High" "IsMasterProtein" "Q9H8V3" "Protein ECT2 OS=Homo sapiens OX=9606 GN=ECT2 PE=1 SV=4" "0.004" "False" "2.742" "2" "2" "2" "2" "914" "103.4" "7.71" "4.31" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00533, Pf00621, Pf12738, Pf21242, Pf21243" "1894" "ENSG00000114346" "ECT2" "hsa:1894; Q0MT80; Q2M269; Q6U836; Q9H8V3; Q9NSV8; Q9NVW9" "Gastric cancer network 1" "CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOA GTPase cycle; RHOB GTPase cycle" "7" "0" "1.093" "1.128" "1.418" "1.195" "1.157" "1.193" "1.015" "0.981" "1.090" "188.7" "206.2" "212.9" "267.7" "225.5" "218.2" "225.0" "191.5" "185.2" "205.8" "" "" "" "" "" "" "" "" "" "" "176.8" "170.6" "197.7" "206.9" "192.2" "208.5" "205.6" "170.0" "185.2" "198.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1178215793923997367" "False" "High" "IsMasterProtein" "Q96DM3" "Regulator of MON1-CCZ1 complex OS=Homo sapiens OX=9606 GN=RMC1 PE=1 SV=2" "0.004" "False" "2.741" "2" "1" "1" "1" "657" "74.9" "7.83" "0.00" "1" "other metabolic processes;other biological processes" "other membranes;other cytoplasmic organelle" "" "Pf07035, Pf21029" "29919" "ENSG00000141452" "RMC1" "Q96DM3; Q9BU17; Q9Y5M0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8635036141062544876" "False" "High" "IsMasterProtein" "P52655" "Transcription initiation factor IIA subunit 1 OS=Homo sapiens OX=9606 GN=GTF2A1 PE=1 SV=1" "0.004" "False" "2.727" "3" "1" "1" "1" "376" "41.5" "4.55" "3.41" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03153" "2957" "ENSG00000165417" "GTF2A1" "hsa:2957; P52655; Q3KNQ9" "" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Estrogen-dependent gene expression" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5243679290783972836" "False" "High" "IsMasterProtein" "Q5JPE7" "BOS complex subunit NOMO2 OS=Homo sapiens OX=9606 GN=NOMO2 PE=1 SV=1" "0.004" "False" "2.726" "1" "1" "1" "1" "1267" "139.4" "5.76" "0.00" "1" "cell organization and biogenesis" "other membranes;cytosol;ER/Golgi;other cell component" "translation activity;other molecular function" "Pf13620, Pf17802" "283820" "ENSG00000185164" "NOMO2" "hsa:283820; Q4G177; Q5JPE7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2414375605373432376" "False" "High" "IsMasterProtein" "Q8TCU4" "Centrosome-associated protein ALMS1 OS=Homo sapiens OX=9606 GN=ALMS1 PE=1 SV=4" "0.004" "False" "2.723" "0" "1" "1" "1" "4168" "460.8" "6.28" "2.91" "1" "transport;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf15309, Pf18727" "7840" "ENSG00000116127" "ALMS1" "A0A087WZY3; hsa:7840; Q53S05; Q580Q8; Q86VP9; Q8TCU4; Q9Y4G4" "Ciliopathies; Alstrom syndrome" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "9" "0" "1.145" "0.788" "1.031" "1.017" "0.873" "0.950" "0.714" "0.820" "0.993" "54.8" "62.7" "43.2" "56.5" "55.7" "47.8" "52.0" "39.1" "44.9" "54.4" "" "" "" "" "" "" "" "" "" "" "51.3" "51.9" "40.1" "43.7" "47.5" "45.7" "47.6" "34.7" "44.9" "52.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5616367941086101468" "False" "High" "IsMasterProtein" "Q9NRW7" "Vacuolar protein sorting-associated protein 45 OS=Homo sapiens OX=9606 GN=VPS45 PE=1 SV=1" "0.004" "False" "2.721" "3" "2" "2" "2" "570" "65.0" "8.24" "4.40" "2" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle" "" "Pf00995" "11311" "ENSG00000136631" "VPS45" "D3DUZ9; F5H8K1; hsa:11311; Q15715; Q53FR8; Q5T4P6; Q9NRW7; Q9Y4Z6" "" "Factors involved in megakaryocyte development and platelet production; Intra-Golgi traffic; SARS-CoV-2 modulates autophagy" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "155133754937223753" "False" "High" "IsMasterProtein" "O43402" "ER membrane protein complex subunit 8 OS=Homo sapiens OX=9606 GN=EMC8 PE=1 SV=1" "0.004" "False" "2.714" "4" "1" "1" "1" "210" "23.8" "6.40" "3.16" "1" "cell organization and biogenesis" "other membranes;ER/Golgi;other cell component" "" "Pf03665" "10328" "ENSG00000131148" "EMC8" "C9JB21; hsa:10328; O43402" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-263774820605261131" "False" "High" "IsMasterProtein" "Q9BTK6" "PAXIP1-associated glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=PAGR1 PE=1 SV=1" "0.004" "False" "2.713" "4" "1" "1" "1" "254" "27.7" "4.46" "3.19" "1" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf15364" "79447" "ENSG00000280789" "PAGR1" "A2ICR6; hsa:79447; Q9BTK6" "16p11.2 proximal deletion syndrome; Kleefstra syndrome" "Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis" "4" "0" "1.134" "0.900" "1.131" "1.013" "1.079" "0.944" "0.823" "0.926" "1.021" "60.3" "68.4" "54.3" "68.3" "61.1" "65.1" "56.9" "49.6" "55.9" "61.6" "" "" "" "" "" "" "" "" "" "" "56.5" "56.6" "50.4" "52.8" "52.1" "62.2" "52.0" "44.1" "55.9" "59.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6683808966160304215" "False" "High" "IsMasterProtein" "P78560" "Death domain-containing protein CRADD OS=Homo sapiens OX=9606 GN=CRADD PE=1 SV=1" "0.004" "False" "2.709" "4" "1" "1" "1" "199" "22.7" "6.80" "2.93" "1" "cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00531, Pf00619" "8738" "ENSG00000169372" "CRADD" "B7Z2Q5; hsa:8738; P78560" "Apoptosis" "TP53 Regulates Transcription of Caspase Activators and Caspases" "2" "0" "1.036" "1.030" "1.013" "1.060" "1.063" "0.956" "1.011" "1.021" "1.147" "209.0" "216.4" "215.2" "211.6" "221.4" "222.2" "199.8" "211.3" "213.4" "239.7" "" "" "" "" "" "" "" "" "" "" "195.8" "179.1" "199.8" "163.6" "188.7" "212.3" "182.6" "187.6" "213.4" "230.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1475037397769826540" "False" "High" "IsMasterProtein" "O75817" "Ribonuclease P protein subunit p20 OS=Homo sapiens OX=9606 GN=POP7 PE=1 SV=2" "0.004" "False" "2.704" "6" "1" "1" "1" "140" "15.6" "8.94" "3.10" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12328" "10248" "ENSG00000172336" "POP7" "A4D2E0; hsa:10248; O75817; Q9BV74" "" "tRNA processing in the nucleus" "1" "0" "0.957" "0.978" "0.971" "1.193" "0.911" "1.106" "1.144" "1.065" "1.084" "48.8" "46.6" "47.7" "47.4" "58.2" "44.4" "53.9" "55.8" "51.9" "52.9" "" "" "" "" "" "" "" "" "" "" "45.7" "38.6" "44.3" "36.6" "49.6" "42.5" "49.3" "49.5" "51.9" "50.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3652671627369165893" "False" "High" "IsMasterProtein" "Q9HBM1" "Kinetochore protein Spc25 OS=Homo sapiens OX=9606 GN=SPC25 PE=1 SV=1" "0.004" "False" "2.703" "4" "1" "1" "1" "224" "26.1" "8.00" "3.08" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf08234" "57405" "ENSG00000152253; ENSG00000277909" "SPC25" "A8K4X8; D3DPC0; hsa:57405; Q9HBM1" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4099103662110185134" "False" "High" "IsMasterProtein" "Q08722" "Leukocyte surface antigen CD47 OS=Homo sapiens OX=9606 GN=CD47 PE=1 SV=1" "0.004" "False" "2.698" "2" "1" "2" "1" "323" "35.2" "7.21" "1.98" "1" "cell adhesion;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf04549, Pf08204" "961" "ENSG00000196776" "CD47" "A8K198; D3DN59; hsa:961; Q08722; Q53Y71; Q96A60" "Spinal cord injury; Pleural mesothelioma" "Neutrophil degranulation; Integrin cell surface interactions; Cell surface interactions at the vascular wall; Signal regulatory protein family interactions" "6" "0" "1.005" "1.193" "1.028" "1.059" "1.044" "1.014" "1.106" "1.002" "1.026" "107.8" "108.3" "128.7" "110.9" "114.2" "112.6" "109.4" "119.3" "108.1" "110.7" "" "" "" "" "" "" "" "" "" "" "101.1" "89.7" "119.4" "85.7" "97.3" "107.6" "100.0" "105.9" "108.1" "106.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8566707279340017586" "False" "High" "IsMasterProtein" "Q9Y6M7" "Sodium bicarbonate cotransporter 3 OS=Homo sapiens OX=9606 GN=SLC4A7 PE=1 SV=2" "0.004" "False" "2.696" "1" "1" "1" "1" "1214" "136.0" "6.71" "3.13" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00955, Pf07565" "9497" "ENSG00000033867" "SLC4A7" "A6NIA8; B2CI53; B5M449; B5M451; B5M452; B5M453; B6DY52; B6DY53; C9JST9; D3K174; D3K175; hsa:9497; O60350; Q6AHZ9; Q9HC88; Q9UIB9; Q9Y6M7" "IL-18 signaling pathway" "RHOJ GTPase cycle; RHOQ GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; RHOH GTPase cycle; Bicarbonate transporters" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2869722740218249638" "False" "High" "IsMasterProtein" "Q9Y6M4" "Casein kinase I isoform gamma-3 OS=Homo sapiens OX=9606 GN=CSNK1G3 PE=1 SV=2" "0.004" "False" "2.691" "2" "1" "1" "1" "447" "51.4" "9.22" "2.34" "1" "cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12605" "1456" "ENSG00000151292" "CSNK1G3" "A8K040; B4DSH2; B7Z9Q4; E7EVD0; hsa:1456; Q86WZ7; Q9Y6M3; Q9Y6M4" "Hedgehog signaling pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7553629148494009655" "False" "High" "IsMasterProtein" "Q14781" "Chromobox protein homolog 2 OS=Homo sapiens OX=9606 GN=CBX2 PE=1 SV=2" "0.004" "False" "2.682" "2" "1" "1" "1" "532" "56.0" "10.01" "2.56" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00385, Pf17218" "84733" "ENSG00000173894" "CBX2" "hsa:84733; Q0VDA5; Q14781; Q9BTB1" "Mammalian disorder of sexual development; Primary ovarian insufficiency" "Oxidative Stress Induced Senescence; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription" "10" "0" "1.266" "1.050" "1.146" "1.139" "1.034" "0.983" "1.107" "0.983" "1.173" "47.5" "60.2" "49.9" "54.5" "54.1" "49.1" "46.7" "52.6" "46.7" "55.7" "" "" "" "" "" "" "" "" "" "" "44.5" "49.8" "46.3" "42.1" "46.1" "46.9" "42.7" "46.7" "46.7" "53.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7089722272324942505" "False" "High" "IsMasterProtein" "Q9NU23" "LYR motif-containing protein 2 OS=Homo sapiens OX=9606 GN=LYRM2 PE=1 SV=1" "0.004" "False" "2.679" "9" "1" "1" "1" "88" "10.4" "10.46" "3.01" "1" "cell organization and biogenesis" "mitochondrion" "" "Pf05347" "57226" "ENSG00000083099" "LYRM2" "B2R4U2; E1P517; hsa:57226; Q9NU23" "" "" "0" "0" "0.947" "0.935" "0.976" "0.970" "0.984" "0.905" "1.011" "0.943" "0.857" "167.9" "159.0" "156.9" "163.8" "162.8" "165.2" "151.9" "169.6" "158.3" "143.9" "" "" "" "" "" "" "" "" "" "" "157.3" "131.5" "145.7" "126.7" "138.8" "157.9" "138.8" "150.6" "158.3" "138.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3285411290895157654" "False" "High" "IsMasterProtein" "Q9H6H4" "Receptor expression-enhancing protein 4 OS=Homo sapiens OX=9606 GN=REEP4 PE=1 SV=1" "0.004" "False" "2.678" "3" "1" "1" "1" "257" "29.4" "9.73" "2.29" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;cytoskeleton;ER/Golgi" "cytoskeletal activity" "Pf03134" "80346" "ENSG00000168476" "REEP4" "D3DSQ9; hsa:80346; Q86VL1; Q9H6H4; Q9H6I5; Q9HBP4" "" "" "0" "0" "1.485" "1.078" "1.633" "1.213" "0.881" "1.437" "1.130" "0.964" "1.018" "142.8" "212.1" "153.9" "233.2" "173.2" "125.8" "205.1" "161.3" "137.6" "145.3" "" "" "" "" "" "" "" "" "" "" "133.8" "175.5" "142.9" "180.2" "147.6" "120.2" "187.4" "143.2" "137.6" "139.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7714801153834532541" "False" "High" "IsMasterProtein" "O14733" "Dual specificity mitogen-activated protein kinase kinase 7 OS=Homo sapiens OX=9606 GN=MAP2K7 PE=1 SV=2" "0.004" "False" "2.676" "2" "1" "1" "1" "419" "47.5" "9.16" "2.72" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5609" "ENSG00000076984" "MAP2K7" "B2R9S5; D6W659; hsa:5609; O14648; O14733; O14816; O60452; O60453; Q1PG43; Q8IY10" "MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Photodynamic therapy-induced AP-1 survival signaling; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Alzheimer's disease; GNAQ pathways in port-wine stain; ErbB signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Uptake and function of anthrax toxins" "28" "0" "0.874" "0.954" "0.965" "1.015" "0.986" "0.892" "0.984" "0.904" "0.954" "126.9" "110.9" "121.0" "122.4" "128.7" "125.1" "113.2" "124.8" "114.6" "121.1" "" "" "" "" "" "" "" "" "" "" "118.9" "91.8" "112.3" "94.6" "109.7" "119.5" "103.4" "110.8" "114.6" "116.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2753373290981074159" "False" "High" "IsMasterProtein" "Q8IXI1" "Mitochondrial Rho GTPase 2 OS=Homo sapiens OX=9606 GN=RHOT2 PE=1 SV=2" "0.004" "False" "2.674" "1" "1" "1" "1" "618" "68.1" "5.86" "2.25" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00071, Pf08355, Pf08356" "89941" "ENSG00000140983" "RHOT2" "A2IDC2; hsa:89941; Q8IXI1; Q8NF53; Q96C13; Q96S17; Q9BT60; Q9H7M8" "" "RHOT2 GTPase cycle" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3499966319797164374" "False" "High" "IsMasterProtein" "Q9UKZ1" "CCR4-NOT transcription complex subunit 11 OS=Homo sapiens OX=9606 GN=CNOT11 PE=1 SV=1" "0.004" "False" "2.664" "2" "1" "2" "1" "510" "55.2" "6.40" "5.97" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10155" "55571" "ENSG00000158435" "CNOT11" "hsa:55571; Q6P2M9; Q8N681; Q9UKZ1" "" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7044477500846696439" "False" "High" "IsMasterProtein" "Q96DP5" "Methionyl-tRNA formyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=MTFMT PE=1 SV=2" "0.004" "False" "2.663" "3" "1" "1" "1" "389" "43.8" "9.66" "2.93" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00551, Pf02911" "123263" "ENSG00000103707" "MTFMT" "B7Z734; hsa:123263; Q96DP5" "One-carbon metabolism" "Mitochondrial translation initiation" "2" "0" "1.185" "1.048" "1.554" "1.293" "1.250" "1.407" "1.127" "1.257" "1.203" "55.6" "65.8" "58.2" "86.3" "71.8" "69.4" "78.2" "62.6" "69.8" "66.8" "" "" "" "" "" "" "" "" "" "" "52.1" "54.5" "54.1" "66.7" "61.2" "66.4" "71.4" "55.6" "69.8" "64.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1616838055589481768" "False" "High" "IsMasterProtein" "Q86V97" "Kelch repeat and BTB domain-containing protein 6 OS=Homo sapiens OX=9606 GN=KBTBD6 PE=1 SV=1" "0.004" "False" "2.658" "1" "1" "1" "1" "674" "76.1" "6.07" "3.29" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00651, Pf01344, Pf07707, Pf20165" "89890" "ENSG00000165572" "KBTBD6" "hsa:89890; Q5T6Y8; Q86V97; Q8N8L0; Q8NDM5; Q96MP6" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "0.907" "1.005" "1.038" "1.025" "1.017" "0.937" "0.971" "1.006" "1.023" "314.9" "285.7" "316.5" "326.9" "322.7" "320.3" "295.0" "305.9" "317.0" "322.1" "" "" "" "" "" "" "" "" "" "" "295.1" "236.4" "293.8" "252.7" "275.1" "306.1" "269.6" "271.6" "317.0" "310.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-577333653668623519" "False" "High" "IsMasterProtein" "Q9HAD4" "WD repeat-containing protein 41 OS=Homo sapiens OX=9606 GN=WDR41 PE=1 SV=3" "0.004" "False" "2.652" "2" "1" "1" "1" "459" "51.7" "5.44" "3.32" "1" "other metabolic processes;other biological processes" "other cell component" "" "Pf00400" "55255" "ENSG00000164253" "WDR41" "B4DT55; hsa:55255; Q7Z792; Q8IWG3; Q8IXA9; Q8NDA7; Q9HAD4; Q9NV62" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "713100355738171482" "False" "High" "IsMasterProtein" "Q8N302" "Angiogenic factor with G patch and FHA domains 1 OS=Homo sapiens OX=9606 GN=AGGF1 PE=1 SV=2" "0.004" "False" "2.640" "1" "1" "1" "1" "714" "80.9" "5.44" "2.33" "1" "cell adhesion;developmental processes;other biological processes" "non-structural extracellular;other cell component" "nucleic acid binding activity" "Pf00498, Pf01585, Pf17780" "55109" "ENSG00000164252" "AGGF1" "hsa:55109; O00581; Q53YS3; Q8N302; Q9BU84; Q9NW66" "" "Signaling by BRAF and RAF1 fusions" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2436656635601103317" "False" "High" "IsMasterProtein" "Q3ZCW2" "Galectin-related protein OS=Homo sapiens OX=9606 GN=LGALSL PE=1 SV=2" "0.004" "False" "2.634" "6" "1" "1" "1" "172" "19.0" "5.35" "2.02" "1" "" "" "other molecular function" "Pf00337" "29094" "ENSG00000119862" "LGALSL" "B2RBG8; D6W5E8; hsa:29094; Q3ZCW2; Q6P5T6; Q9P005" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8018768357268208371" "False" "High" "IsMasterProtein" "Q9P1U0" "DNA-directed RNA polymerase I subunit RPA12 OS=Homo sapiens OX=9606 GN=POLR1H PE=1 SV=1" "0.004" "False" "2.633" "15" "2" "2" "2" "126" "13.9" "5.06" "2.61" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01096" "30834" "ENSG00000066379; ENSG00000206502; ENSG00000224859; ENSG00000233795; ENSG00000235176; ENSG00000235443; ENSG00000236808; ENSG00000236949" "POLR1H" "hsa:30834; Q9P1U0" "Pyrimidine metabolism; 2q13 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "7" "0" "1.067" "0.952" "1.142" "1.170" "1.071" "1.058" "1.146" "0.992" "1.038" "193.7" "206.7" "184.5" "221.3" "226.6" "207.5" "204.9" "222.1" "192.2" "201.0" "" "" "" "" "" "" "" "" "" "" "181.5" "171.1" "171.2" "171.1" "193.2" "198.2" "187.3" "197.2" "192.2" "193.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6484824469682462574" "False" "High" "IsMasterProtein" "Q17R31" "Putative deoxyribonuclease TATDN3 OS=Homo sapiens OX=9606 GN=TATDN3 PE=1 SV=1" "0.004" "False" "2.623" "3" "1" "1" "1" "274" "30.3" "7.15" "2.67" "1" "" "nucleus" "other molecular function" "Pf01026" "128387" "ENSG00000203705" "TATDN3" "A6NGS3; B7Z1C1; B7Z978; B7ZLQ6; E9PJE5; E9PNH3; G3V151; hsa:128387; Q17R31; Q4G0L1" "" "" "0" "0" "1.110" "1.027" "1.137" "1.071" "1.136" "1.148" "1.104" "1.129" "1.100" "205.8" "228.4" "211.4" "233.9" "220.5" "233.9" "236.3" "227.2" "232.4" "226.3" "" "" "" "" "" "" "" "" "" "" "192.8" "189.0" "196.2" "180.8" "187.9" "223.4" "215.9" "201.7" "232.4" "217.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6530118680274496318" "False" "High" "IsMasterProtein" "Q9UHB7" "AF4/FMR2 family member 4 OS=Homo sapiens OX=9606 GN=AFF4 PE=1 SV=1" "0.004" "False" "2.621" "2" "2" "2" "2" "1163" "127.4" "9.31" "2.89" "2" "stress response;other biological processes" "nucleus;other cell component" "" "Pf05110, Pf18875, Pf18876" "27125" "ENSG00000072364" "AFF4" "B2RP19; B7WPD2; hsa:27125; Q498B2; Q59FB3; Q6P592; Q8TDR1; Q9P0E4; Q9UHB7" "" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5965244756027354747" "False" "High" "IsMasterProtein" "O75414" "Nucleoside diphosphate kinase 6 OS=Homo sapiens OX=9606 GN=NME6 PE=1 SV=3" "0.004" "False" "2.617" "7" "1" "1" "1" "186" "21.1" "8.32" "2.66" "1" "other metabolic processes;other biological processes" "mitochondrion" "kinase activity;other molecular function" "Pf00334" "10201" "ENSG00000172113" "NME6" "B4DGW7; B4DM99; hsa:10201; O75414; Q53HM5; Q96E73; Q9BQ63" "Pyrimidine metabolism" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2052900039050687679" "False" "High" "IsMasterProtein" "Q9Y6X3" "MAU2 chromatid cohesion factor homolog OS=Homo sapiens OX=9606 GN=MAU2 PE=1 SV=2" "0.004" "False" "2.609" "1" "1" "1" "1" "613" "69.0" "7.25" "1.97" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10345" "23383" "ENSG00000129933" "MAU2" "hsa:23383; Q66PT1; Q6P3S7; Q6ZTT2; Q9UFX8; Q9Y6X3" "Cohesin complex - Cornelia de Lange syndrome" "Cohesin Loading onto Chromatin" "2" "0" "0.971" "0.942" "1.131" "1.052" "1.079" "1.422" "1.362" "1.246" "1.074" "108.4" "105.3" "102.1" "122.6" "114.1" "117.0" "154.2" "147.7" "135.1" "116.4" "" "" "" "" "" "" "" "" "" "" "101.6" "87.1" "94.8" "94.7" "97.2" "111.8" "140.9" "131.1" "135.1" "112.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6717831225161761415" "False" "High" "IsMasterProtein" "P46100" "Transcriptional regulator ATRX OS=Homo sapiens OX=9606 GN=ATRX PE=1 SV=6" "0.004" "False" "2.606" "1" "1" "1" "1" "2492" "282.4" "6.55" "2.12" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf17981" "546" "ENSG00000085224" "ATRX" "D3DTE2; P46100; P51068; Q15886; Q59FB5; Q59H31; Q5H9A2; Q5JWI4; Q7Z2J1; Q9H0Z1; Q9NTS3" "Pathways affected in adenoid cystic carcinoma" "Inhibition of DNA recombination at telomere; Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations; Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-337966676989864898" "False" "High" "IsMasterProtein" "Q96LB3" "Intraflagellar transport protein 74 homolog OS=Homo sapiens OX=9606 GN=IFT74 PE=1 SV=1" "0.004" "False" "2.604" "2" "1" "1" "1" "600" "69.2" "6.00" "2.44" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "80173" "ENSG00000096872" "IFT74" "hsa:80173; Q3B789; Q5VY34; Q6PGQ8; Q96LB3; Q9H643; Q9H8G7" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Alstrom syndrome; Bardet-Biedl syndrome" "Intraflagellar transport" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2465041974174611566" "False" "High" "IsMasterProtein" "Q96BT7" "Alkylated DNA repair protein alkB homolog 8 OS=Homo sapiens OX=9606 GN=ALKBH8 PE=1 SV=2" "0.004" "False" "2.587" "1" "1" "1" "1" "664" "75.2" "7.99" "2.53" "1" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08241, Pf09004, Pf13532" "91801" "ENSG00000137760" "ALKBH8" "B1Q2M0; B4DEF6; hsa:91801; Q8N989; Q96BT7" "" "tRNA modification in the nucleus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "935705506060532462" "False" "High" "IsMasterProtein" "A0A0U1RRE5" "Negative regulator of P-body association OS=Homo sapiens OX=9606 GN=NBDY PE=1 SV=1" "0.004" "False" "2.586" "12" "1" "2" "1" "68" "7.0" "9.42" "5.04" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "" "" "550643" "ENSG00000204272" "NBDY" "A0A0U1RRE5" "" "" "0" "0" "0.987" "0.894" "1.143" "1.047" "0.975" "0.996" "0.979" "1.008" "0.973" "71.9" "71.0" "64.3" "82.1" "75.2" "70.1" "71.6" "70.4" "72.4" "70.0" "" "" "" "" "" "" "" "" "" "" "67.3" "58.7" "59.7" "63.5" "64.1" "67.0" "65.4" "62.5" "72.4" "67.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "53418054531759760" "False" "High" "IsMasterProtein" "Q86Y79" "Peptidyl-tRNA hydrolase OS=Homo sapiens OX=9606 GN=PTRH1 PE=1 SV=1" "0.004" "False" "2.585" "5" "1" "1" "1" "214" "22.9" "10.56" "3.18" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "" "other molecular function" "Pf01195" "138428" "ENSG00000187024" "PTRH1" "hsa:138428; Q86Y79" "" "" "0" "0" "1.230" "1.153" "1.184" "1.145" "1.075" "1.351" "1.144" "1.040" "1.117" "45.2" "55.6" "52.2" "53.6" "51.8" "48.6" "61.1" "51.7" "47.1" "50.5" "" "" "" "" "" "" "" "" "" "" "42.4" "46.0" "48.5" "41.4" "44.1" "46.5" "55.9" "45.9" "47.1" "48.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3376743551660886452" "False" "High" "IsMasterProtein" "Q8N5L8" "Ribonuclease P protein subunit p25-like protein OS=Homo sapiens OX=9606 GN=RPP25L PE=1 SV=1" "0.004" "False" "2.578" "6" "1" "1" "1" "163" "17.6" "10.30" "2.30" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf01918" "138716" "ENSG00000164967" "RPP25L" "D3DRM5; hsa:138716; Q8N5L8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1468795769571451317" "False" "High" "IsMasterProtein" "Cont_P06868" "Plasminogen OS=Bos taurus OX=9913 GN=PLG PE=1 SV=2" "0.004" "True" "2.574" "1" "1" "1" "1" "812" "91.2" "7.50" "0.00" "1" "protein metabolism;stress response;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding;other molecular function" "Pf00024, Pf00051, Pf00089" "280897" "" "PLG" "bta:280897; P06868; Q28162" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6501197997906174593" "False" "High" "IsMasterProtein" "Q16671" "Anti-Muellerian hormone type-2 receptor OS=Homo sapiens OX=9606 GN=AMHR2 PE=1 SV=1" "0.004" "False" "2.564" "2" "1" "3" "1" "573" "62.7" "5.81" "0.00" "1" "other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "kinase activity;other molecular function" "Pf00069" "269" "ENSG00000135409" "AMHR2" "A0AVE1; B9EGB7; E9PGD2; F8W1D2; hsa:269; Q13762; Q16671; Q647K2" "Mammalian disorder of sexual development; Primary ovarian insufficiency" "Signaling by BMP" "3" "0" "1.079" "0.915" "1.469" "1.105" "0.800" "1.045" "0.773" "1.002" "0.938" "24.7" "26.7" "22.6" "36.3" "27.3" "19.8" "25.9" "19.1" "24.8" "23.2" "" "" "" "" "" "" "" "" "" "" "23.2" "22.1" "21.0" "28.1" "23.3" "18.9" "23.6" "17.0" "24.8" "22.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2280173954628743823" "False" "High" "IsMasterProtein" "Q9Y575" "Ankyrin repeat and SOCS box protein 3 OS=Homo sapiens OX=9606 GN=ASB3 PE=1 SV=1" "0.004" "False" "2.560" "3" "1" "1" "1" "518" "57.7" "6.27" "0.00" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "" "Pf07525, Pf12796" "100302652; 51130" "ENSG00000115239" "ASB3" "B3KPA3; D6W5B4; D6W5B5; G8JLA9; hsa:100302652; hsa:51130; Q2TAI4; Q53TN0; Q53TN8; Q9NVZ2; Q9Y575" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "0.888" "1.031" "1.530" "1.468" "1.136" "1.235" "1.202" "1.072" "0.996" "29.0" "25.7" "29.9" "44.4" "42.6" "33.0" "35.8" "34.9" "31.1" "28.9" "" "" "" "" "" "" "" "" "" "" "27.2" "21.3" "27.8" "34.3" "36.3" "31.5" "32.7" "31.0" "31.1" "27.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7269919126570467546" "False" "High" "IsMasterProtein" "Q16514" "Transcription initiation factor TFIID subunit 12 OS=Homo sapiens OX=9606 GN=TAF12 PE=1 SV=1" "0.004" "False" "2.554" "5" "1" "1" "1" "161" "17.9" "7.99" "3.20" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03847" "6883" "ENSG00000120656" "TAF12" "D3DPM5; hsa:6883; Q15775; Q16514; Q5T077" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; HATs acetylate histones" "11" "0" "0.904" "0.848" "1.016" "1.011" "0.915" "0.930" "0.880" "0.925" "0.894" "126.6" "114.5" "107.3" "128.7" "128.0" "115.8" "117.7" "111.3" "117.1" "113.2" "" "" "" "" "" "" "" "" "" "" "118.6" "94.7" "99.6" "99.5" "109.1" "110.7" "107.5" "98.9" "117.1" "109.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4925362542189153162" "False" "High" "IsMasterProtein" "Q92854" "Semaphorin-4D OS=Homo sapiens OX=9606 GN=SEMA4D PE=1 SV=1" "0.004" "False" "2.553" "1" "1" "1" "1" "862" "96.1" "7.96" "2.22" "1" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00047, Pf01403, Pf01437" "10507" "ENSG00000187764" "SEMA4D" "B2RPM6; hsa:10507; Q7Z5S4; Q8N8B0; Q92854" "Clock-controlled autophagy in bone metabolism" "Sema4D induced cell migration and growth-cone collapse; Other semaphorin interactions; Sema4D mediated inhibition of cell attachment and migration" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1498458301552967093" "False" "High" "IsMasterProtein" "P13716" "Delta-aminolevulinic acid dehydratase OS=Homo sapiens OX=9606 GN=ALAD PE=1 SV=1" "0.004" "False" "2.550" "3" "1" "1" "1" "330" "36.3" "6.79" "2.91" "1" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf00490" "210" "ENSG00000148218" "ALAD" "A8K375; B2R6F2; hsa:210; P13716; Q16870; Q16871; Q9BVQ9" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Neutrophil degranulation; Heme biosynthesis" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5021864284547303722" "False" "High" "IsMasterProtein" "Q96GD4" "Aurora kinase B OS=Homo sapiens OX=9606 GN=AURKB PE=1 SV=3" "0.004" "False" "2.549" "2" "1" "1" "1" "344" "39.3" "9.29" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "9212" "ENSG00000178999" "AURKB" "B4DNM4; C7G533; C7G534; C7G535; D3DTR4; hsa:9212; J9JID1; O14630; O60446; O95083; Q96DV5; Q96GD4; Q9UQ46" "Microtubule cytoskeleton regulation; ATM signaling in development and disease" "Regulation of TP53 Activity through Phosphorylation; RHO GTPases Activate Formins; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Regulation of MECP2 expression and activity; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; SUMOylation of DNA replication proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "12" "0" "0.844" "0.920" "1.033" "0.927" "0.960" "1.047" "0.861" "1.020" "1.019" "93.0" "78.5" "85.6" "96.1" "86.2" "89.3" "97.3" "80.1" "94.8" "94.8" "" "" "" "" "" "" "" "" "" "" "87.1" "64.9" "79.4" "74.3" "73.4" "85.3" "88.9" "71.1" "94.8" "91.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5519015022968038253" "False" "High" "IsMasterProtein" "Q86X10" "Ral GTPase-activating protein subunit beta OS=Homo sapiens OX=9606 GN=RALGAPB PE=1 SV=1" "0.004" "False" "2.538" "1" "1" "1" "1" "1494" "166.7" "6.79" "3.16" "1" "other biological processes" "" "enzyme regulator activity;other molecular function" "Pf20412" "57148" "ENSG00000170471" "RALGAPB" "A2A2E8; A2A2E9; hsa:57148; Q5TG31; Q86X10; Q8N3D1; Q8WWC0; Q9H3X8; Q9UJR1; Q9ULK1; Q9Y3G9" "" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "1" "0" "0.880" "0.884" "0.889" "0.969" "0.927" "0.959" "0.873" "0.838" "0.997" "57.5" "50.6" "50.8" "51.1" "55.7" "53.3" "55.1" "50.2" "48.2" "57.3" "" "" "" "" "" "" "" "" "" "" "53.9" "41.9" "47.2" "39.5" "47.5" "50.9" "50.4" "44.6" "48.2" "55.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5146194763557846941" "False" "High" "IsMasterProtein" "Q9Y613" "FH1/FH2 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FHOD1 PE=1 SV=3" "0.004" "False" "2.534" "1" "1" "1" "1" "1164" "126.5" "6.39" "2.66" "1" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02181, Pf18382" "29109" "ENSG00000135723" "FHOD1" "hsa:29109; Q59F76; Q6Y1F2; Q76MS8; Q8N521; Q9Y613" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.123" "1.038" "1.180" "1.099" "1.116" "1.108" "1.026" "1.084" "1.073" "164.6" "184.8" "170.9" "194.1" "180.8" "183.7" "182.4" "168.9" "178.4" "176.6" "" "" "" "" "" "" "" "" "" "" "154.2" "152.9" "158.6" "150.1" "154.1" "175.5" "166.6" "150.0" "178.4" "170.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6562177240292846235" "False" "High" "IsMasterProtein" "Q99490" "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=AGAP2 PE=1 SV=2" "0.004" "False" "2.525" "1" "1" "1" "1" "1192" "124.6" "9.89" "2.83" "1" "cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf00071, Pf01412" "116986" "ENSG00000135439" "AGAP2" "A8K9F7; hsa:116986; O00578; Q548E0; Q8IWU3; Q99490" "Prolactin signaling pathway; Fragile X syndrome; Netrin-UNC5B signaling pathway; 15q25 copy number variation" "Netrin-1 signaling" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5785864881110335023" "False" "High" "IsMasterProtein" "Q5T6S3" "PHD finger protein 19 OS=Homo sapiens OX=9606 GN=PHF19 PE=1 SV=1" "0.004" "False" "2.511" "2" "1" "1" "1" "580" "65.5" "8.84" "2.13" "1" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf14061, Pf18104" "26147" "ENSG00000119403" "PHF19" "hsa:26147; Q32NF2; Q5T6S3; Q5T6S4; Q6N038; Q8TBL6; Q9UFS9" "Genes associated with the development of rheumatoid arthritis" "PRC2 methylates histones and DNA" "2" "0" "1.046" "1.103" "1.007" "1.073" "1.090" "1.035" "1.178" "1.123" "1.114" "106.3" "111.1" "117.2" "107.0" "114.0" "115.9" "110.0" "125.2" "119.3" "118.4" "" "" "" "" "" "" "" "" "" "" "99.6" "92.0" "108.8" "82.7" "97.2" "110.7" "100.5" "111.2" "119.3" "114.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1540288173630827229" "False" "High" "IsMasterProtein" "Q15413" "Ryanodine receptor 3 OS=Homo sapiens OX=9606 GN=RYR3 PE=1 SV=3" "0.004" "False" "2.504" "0" "1" "1" "1" "4870" "551.7" "5.68" "2.58" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi" "transporter activity;other molecular function" "Pf00520, Pf00622, Pf01365, Pf02026, Pf02815, Pf06459, Pf08454, Pf08709, Pf21119" "6263" "ENSG00000198838" "RYR3" "hsa:6263; O15175; Q15412; Q15413" "Alzheimer's disease and miRNA effects; Myometrial relaxation and contraction pathways; MFAP5-mediated ovarian cancer cell motility and invasiveness; Cell-type dependent selectivity of CCK2R signaling; PKC-gamma calcium signaling pathway in ataxia; Alzheimer's disease; Calcium regulation in cardiac cells" "Stimuli-sensing channels; Ion homeostasis" "9" "0" "1.038" "0.980" "0.933" "0.994" "1.115" "1.015" "1.029" "1.097" "1.076" "260.9" "270.8" "255.8" "243.5" "259.3" "290.8" "264.8" "268.4" "286.2" "280.6" "" "" "" "" "" "" "" "" "" "" "244.5" "224.1" "237.5" "188.2" "221.0" "277.8" "242.0" "238.3" "286.2" "270.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5516546928606197039" "False" "High" "IsMasterProtein" "Q13901" "Nuclear nucleic acid-binding protein C1D OS=Homo sapiens OX=9606 GN=C1D PE=1 SV=1" "0.004" "False" "2.503" "6" "1" "1" "1" "141" "16.0" "9.03" "1.88" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04000" "10438" "ENSG00000197223" "C1D" "A8K336; D6W5F8; hsa:10438; Q05D64; Q13901" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.039" "0.990" "1.065" "1.024" "1.041" "1.001" "0.993" "1.022" "1.079" "271.7" "282.4" "269.1" "289.4" "278.4" "282.8" "271.9" "269.7" "277.7" "293.2" "" "" "" "" "" "" "" "" "" "" "254.6" "233.7" "249.9" "223.7" "237.3" "270.2" "248.5" "239.5" "277.7" "282.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6459567774335388570" "False" "High" "IsMasterProtein" "Q6ZRI6" "Uncharacterized protein C15orf39 OS=Homo sapiens OX=9606 GN=C15orf39 PE=1 SV=3" "0.004" "False" "2.497" "1" "1" "1" "1" "1047" "110.6" "7.64" "3.06" "1" "" "cytosol" "" "Pf17663" "56905" "ENSG00000167173" "C15orf39" "B3KWI3; C9J888; hsa:56905; Q6ZRI6; Q71JB1; Q7L3S0; Q8N3F2; Q96FB6; Q9NTU5" "VEGFA-VEGFR2 signaling" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-155447427223618220" "False" "High" "IsMasterProtein" "A6NFY7" "Succinate dehydrogenase assembly factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF1 PE=1 SV=1" "0.004" "False" "2.497" "14" "1" "1" "1" "115" "12.8" "11.39" "3.03" "1" "cell organization and biogenesis" "mitochondrion;nucleus" "" "Pf05347" "644096" "ENSG00000205138" "SDHAF1" "A6NFY7; B2RPM7; hsa:644096" "Mitochondrial complex II assembly" "" "1" "0" "1.124" "1.072" "1.222" "1.086" "1.226" "1.268" "0.978" "0.967" "0.950" "50.0" "56.2" "53.6" "61.1" "54.3" "61.3" "63.4" "48.9" "48.4" "47.5" "" "" "" "" "" "" "" "" "" "" "46.9" "46.5" "49.8" "47.2" "46.3" "58.6" "57.9" "43.4" "48.4" "45.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8721939623497573862" "False" "High" "IsMasterProtein" "Q86YV5" "Inactive tyrosine-protein kinase PRAG1 OS=Homo sapiens OX=9606 GN=PRAG1 PE=1 SV=4" "0.004" "False" "2.487" "1" "1" "1" "1" "1406" "149.5" "7.20" "2.66" "1" "other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf07714" "157285" "ENSG00000275342" "PRAG1" "Q86YV5; Q8N3N5" "" "RND2 GTPase cycle" "1" "0" "1.148" "1.110" "1.230" "0.959" "0.859" "0.968" "0.899" "1.125" "0.901" "50.8" "58.3" "56.4" "62.5" "48.7" "43.6" "49.2" "45.7" "57.1" "45.8" "" "" "" "" "" "" "" "" "" "" "47.6" "48.2" "52.3" "48.3" "41.5" "41.7" "44.9" "40.5" "57.1" "44.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6408884538734693617" "False" "High" "IsMasterProtein" "Q8IWZ6" "Bardet-Biedl syndrome 7 protein OS=Homo sapiens OX=9606 GN=BBS7 PE=1 SV=2" "0.004" "False" "2.483" "2" "1" "1" "1" "715" "80.3" "6.05" "2.27" "1" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "55212" "ENSG00000138686" "BBS7" "hsa:55212; Q4W5P8; Q8IWZ6; Q8N581; Q9NVI4" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "BBSome-mediated cargo-targeting to cilium" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1838412941252019118" "False" "High" "IsMasterProtein" "Q9Y530" "ADP-ribose glycohydrolase OARD1 OS=Homo sapiens OX=9606 GN=OARD1 PE=1 SV=2" "0.004" "False" "2.476" "5" "1" "1" "1" "152" "17.0" "8.31" "2.18" "1" "protein metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf01661" "221443" "ENSG00000124596" "OARD1" "A6NEK4; A8K4H4; hsa:221443; Q96F23; Q9Y530" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2432573518127271622" "False" "High" "IsMasterProtein" "Q6UUV7" "CREB-regulated transcription coactivator 3 OS=Homo sapiens OX=9606 GN=CRTC3 PE=1 SV=2" "0.004" "False" "2.475" "1" "1" "1" "1" "619" "66.9" "6.84" "3.16" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12884, Pf12885, Pf12886" "64784" "ENSG00000140577" "CRTC3" "hsa:64784; Q6DK61; Q6DK62; Q6UUV7; Q8NF38; Q9H6U2" "" "Transcriptional activation of mitochondrial biogenesis; Heme signaling; Circadian Clock" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "464050174283123941" "False" "High" "IsMasterProtein" "Q13094" "Lymphocyte cytosolic protein 2 OS=Homo sapiens OX=9606 GN=LCP2 PE=1 SV=1" "0.004" "False" "2.475" "2" "1" "1" "1" "533" "60.2" "6.27" "3.15" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf00017, Pf07647" "3937" "ENSG00000043462" "LCP2" "A8KA25; hsa:3937; Q13094; Q53XV4" "T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor signaling pathway" "GPVI-mediated activation cascade; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; Generation of second messenger molecules; DAP12 signaling" "8" "0" "0.992" "0.843" "1.148" "1.112" "1.033" "1.039" "0.927" "0.937" "0.963" "184.1" "182.6" "155.2" "211.4" "204.7" "190.2" "191.2" "170.7" "172.5" "177.2" "" "" "" "" "" "" "" "" "" "" "172.5" "151.1" "144.1" "163.4" "174.5" "181.7" "174.7" "151.6" "172.5" "170.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7723241537824497291" "False" "High" "IsMasterProtein" "Q02388" "Collagen alpha-1(VII) chain OS=Homo sapiens OX=9606 GN=COL7A1 PE=1 SV=2" "0.004" "False" "2.472" "0" "1" "1" "1" "2944" "295.0" "6.27" "3.00" "1" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;other membranes;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00014, Pf00041, Pf00092, Pf01391" "1294" "ENSG00000114270" "COL7A1" "hsa:1294; Q02388; Q14054; Q16507" "" "Collagen degradation; Integrin cell surface interactions; Collagen chain trimerization; COPII-mediated vesicle transport; Cargo concentration in the ER; Laminin interactions; Anchoring fibril formation" "10" "0" "0.576" "0.922" "0.934" "0.879" "0.862" "0.933" "0.862" "0.668" "0.876" "515.1" "296.6" "475.1" "481.3" "452.8" "443.9" "480.6" "443.9" "344.1" "451.4" "" "" "" "" "" "" "" "" "" "" "482.6" "245.5" "441.1" "372.0" "385.9" "424.1" "439.2" "394.1" "344.1" "434.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5609078604117945067" "False" "High" "IsMasterProtein" "Q9H777" "Zinc phosphodiesterase ELAC protein 1 OS=Homo sapiens OX=9606 GN=ELAC1 PE=1 SV=2" "0.004" "False" "2.466" "2" "1" "1" "1" "363" "40.0" "6.79" "2.49" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00753" "55520" "ENSG00000141642" "ELAC1" "hsa:55520; Q9H777; Q9NS99" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-658722355380059482" "False" "High" "IsMasterProtein" "Q9UPN4" "Centrosomal protein of 131 kDa OS=Homo sapiens OX=9606 GN=CEP131 PE=1 SV=3" "0.004" "False" "2.465" "1" "1" "1" "1" "1083" "122.1" "8.69" "2.66" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "22994" "ENSG00000141577" "CEP131" "A6NHI8; B2RN11; hsa:22994; Q96F50; Q9UPN4" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "1.160" "0.984" "1.280" "1.290" "1.070" "1.747" "2.213" "1.593" "2.355" "36.5" "42.4" "35.9" "46.8" "47.1" "39.1" "63.8" "80.9" "58.2" "86.0" "" "" "" "" "" "" "" "" "" "" "34.2" "35.1" "33.4" "36.2" "40.2" "37.3" "58.3" "71.8" "58.2" "82.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4658645955564383119" "False" "High" "IsMasterProtein" "Q86Y82" "Syntaxin-12 OS=Homo sapiens OX=9606 GN=STX12 PE=1 SV=1" "0.004" "False" "2.463" "5" "1" "2" "1" "276" "31.6" "5.59" "1.85" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739, Pf14523" "23673" "ENSG00000117758" "STX12" "B1AJQ7; hsa:23673; O95564; Q86Y82" "" "" "0" "0" "0.981" "0.999" "1.096" "1.076" "1.090" "1.235" "1.172" "1.059" "0.949" "106.2" "104.1" "106.1" "116.3" "114.3" "115.8" "131.2" "124.5" "112.4" "100.8" "" "" "" "" "" "" "" "" "" "" "99.5" "86.2" "98.5" "89.9" "97.4" "110.6" "119.9" "110.5" "112.4" "97.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5058994257240808720" "False" "High" "IsMasterProtein" "Q9ULR5" "Polyadenylate-binding protein-interacting protein 2B OS=Homo sapiens OX=9606 GN=PAIP2B PE=1 SV=2" "0.004" "False" "2.463" "7" "1" "1" "1" "123" "14.2" "4.17" "3.04" "1" "other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf07145" "400961" "ENSG00000124374" "PAIP2B" "hsa:400961; Q9ULR5" "" "" "0" "0" "0.978" "0.950" "0.890" "0.885" "0.984" "0.949" "0.951" "0.967" "1.001" "285.6" "279.4" "271.5" "254.1" "252.7" "281.2" "271.0" "271.6" "276.2" "285.9" "" "" "" "" "" "" "" "" "" "" "267.6" "231.2" "252.0" "196.5" "215.4" "268.6" "247.6" "241.1" "276.2" "275.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7796576881168078978" "False" "High" "IsMasterProtein" "Q9P2R6" "Arginine-glutamic acid dipeptide repeats protein OS=Homo sapiens OX=9606 GN=RERE PE=1 SV=2" "0.005" "False" "2.447" "1" "1" "1" "1" "1566" "172.3" "7.69" "3.06" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00320, Pf01426, Pf01448, Pf03154" "473" "ENSG00000142599" "RERE" "hsa:473; O43393; O75046; O75359; Q5VXL9; Q6P6B9; Q9P2R6; Q9Y2W4" "" "" "0" "0" "0.962" "1.032" "1.049" "1.088" "1.018" "1.008" "1.114" "1.164" "1.120" "211.3" "203.3" "218.1" "221.7" "229.8" "215.2" "212.9" "235.4" "245.9" "236.7" "" "" "" "" "" "" "" "" "" "" "198.0" "168.2" "202.5" "171.4" "195.9" "205.6" "194.6" "209.0" "245.9" "227.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6713698624635577932" "False" "High" "IsMasterProtein" "Q9NWQ9" "Uncharacterized protein C14orf119 OS=Homo sapiens OX=9606 GN=C14orf119 PE=1 SV=1" "0.005" "False" "2.446" "6" "1" "2" "1" "140" "16.0" "4.94" "2.34" "1" "" "cytosol;mitochondrion" "" "Pf14969" "55017" "ENSG00000179933" "C14orf119" "hsa:55017; Q6IAA7; Q9NWQ9" "" "" "0" "0" "1.215" "1.074" "1.191" "1.092" "1.104" "1.059" "1.054" "1.055" "1.150" "110.3" "134.0" "118.5" "131.4" "120.5" "121.8" "116.8" "116.2" "116.4" "126.9" "" "" "" "" "" "" "" "" "" "" "103.4" "110.9" "110.0" "101.6" "102.7" "116.4" "106.7" "103.2" "116.4" "122.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8596564975645279718" "False" "High" "IsMasterProtein" "Q9P0M2" "A-kinase anchor protein 7 isoform gamma OS=Homo sapiens OX=9606 GN=AKAP7 PE=1 SV=2" "0.005" "False" "2.445" "2" "1" "1" "1" "348" "39.5" "6.16" "2.46" "1" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf10469, Pf10470" "9465" "ENSG00000118507" "AKAP7" "B4DUC3; hsa:9465; Q9HCZ8; Q9P0M2" "G protein signaling pathways" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8632982163775733346" "False" "High" "IsMasterProtein" "A6NK58" "Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial OS=Homo sapiens OX=9606 GN=LIPT2 PE=1 SV=1" "0.005" "False" "2.445" "5" "1" "1" "1" "231" "25.2" "8.27" "2.45" "1" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "" "387787" "ENSG00000175536" "LIPT2" "A6NK58; hsa:387787" "" "Glyoxylate metabolism and glycine degradation" "1" "0" "1.174" "1.047" "1.822" "1.820" "1.553" "1.091" "1.142" "1.177" "0.895" "210.8" "247.4" "220.7" "384.1" "383.7" "327.3" "230.1" "240.8" "248.2" "188.7" "" "" "" "" "" "" "" "" "" "" "197.5" "204.8" "204.9" "296.9" "327.1" "312.7" "210.2" "213.8" "248.2" "181.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7676030556128945513" "False" "High" "IsMasterProtein" "Q8WXX7" "Autism susceptibility gene 2 protein OS=Homo sapiens OX=9606 GN=AUTS2 PE=1 SV=1" "0.005" "False" "2.440" "1" "1" "1" "1" "1259" "138.9" "9.38" "2.80" "1" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15336" "26053" "ENSG00000158321" "AUTS2" "A4D1Y9; L7QET3; L7QF75; Q5D049; Q6PJU5; Q8WXX7; Q9Y4F2" "" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "1" "0" "1.039" "0.817" "1.023" "0.808" "0.877" "0.877" "0.876" "0.766" "0.791" "79.7" "82.8" "65.2" "81.5" "64.4" "69.9" "69.9" "69.9" "61.1" "63.1" "" "" "" "" "" "" "" "" "" "" "74.7" "68.5" "60.5" "63.0" "54.9" "66.8" "63.9" "62.0" "61.1" "60.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6345755563908403634" "False" "High" "IsMasterProtein" "Q9NQG7" "BLOC-3 complex member HPS4 OS=Homo sapiens OX=9606 GN=HPS4 PE=1 SV=2" "0.005" "False" "2.438" "1" "1" "1" "1" "708" "76.9" "5.45" "2.53" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf19031, Pf19033" "89781" "ENSG00000100099" "HPS4" "B1AHQ4; Q5H8V6; Q96LX6; Q9BY93; Q9NQG7; Q9UH37; Q9UH38" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8053794800816316585" "False" "High" "IsMasterProtein" "Q9UKU6" "Thyrotropin-releasing hormone-degrading ectoenzyme OS=Homo sapiens OX=9606 GN=TRHDE PE=1 SV=2" "0.005" "False" "2.437" "1" "1" "1" "1" "1069" "122.1" "6.99" "2.95" "1" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "29953" "ENSG00000072657" "TRHDE" "A5PL19; H0YHU0; hsa:29953; Q6UWJ4; Q9UKU6" "" "" "0" "0" "0.695" "0.945" "0.800" "0.868" "0.959" "0.916" "0.887" "0.784" "0.818" "300.2" "208.7" "283.6" "240.1" "260.7" "287.9" "274.9" "266.4" "235.2" "245.7" "" "" "" "" "" "" "" "" "" "" "281.3" "172.7" "263.3" "185.6" "222.2" "275.1" "251.2" "236.5" "235.2" "236.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2506181633878019200" "False" "High" "IsMasterProtein" "P50548" "ETS domain-containing transcription factor ERF OS=Homo sapiens OX=9606 GN=ERF PE=1 SV=2" "0.005" "False" "2.435" "2" "1" "1" "1" "548" "58.7" "7.30" "0.00" "1" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178" "2077" "ENSG00000105722" "ERF" "B2RAP1; B7Z4R0; hsa:2077; P50548; Q59G38; Q9UPI7" "Ciliary landscape" "Oncogene Induced Senescence" "2" "0" "1.026" "1.267" "1.257" "1.226" "1.138" "1.051" "1.097" "1.228" "1.044" "82.6" "84.7" "104.6" "103.7" "101.2" "93.9" "86.7" "90.6" "101.4" "86.2" "" "" "" "" "" "" "" "" "" "" "77.4" "70.1" "97.1" "80.2" "86.3" "89.7" "79.3" "80.4" "101.4" "83.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5660529774365684631" "False" "High" "IsMasterProtein" "Q6WCQ1" "Myosin phosphatase Rho-interacting protein OS=Homo sapiens OX=9606 GN=MPRIP PE=1 SV=3" "0.005" "False" "2.432" "1" "1" "1" "1" "1025" "116.5" "6.21" "2.56" "1" "" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf00169" "23164" "ENSG00000133030" "MPRIP" "hsa:23164; Q3KQZ5; Q5FB94; Q6DHW2; Q6WCQ1; Q7Z5Y2; Q8N390; Q96G40" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Signaling by BRAF and RAF1 fusions" "2" "0" "0.931" "1.147" "1.302" "1.293" "1.192" "1.263" "1.187" "1.278" "1.100" "49.3" "45.9" "56.6" "64.2" "63.8" "58.8" "62.3" "58.5" "63.1" "54.3" "" "" "" "" "" "" "" "" "" "" "46.2" "38.0" "52.5" "49.7" "54.4" "56.2" "56.9" "52.0" "63.1" "52.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6933748794683119105" "False" "High" "IsMasterProtein" "P60673" "Profilin-3 OS=Homo sapiens OX=9606 GN=PFN3 PE=1 SV=1" "0.005" "False" "2.424" "7" "1" "2" "1" "137" "14.6" "9.26" "5.04" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00235" "345456" "ENSG00000196570" "PFN3" "A2RUL3; hsa:345456; P60673" "Physico-chemical features and toxicity-associated pathways; 5q35 copy number variation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9194224885782159223" "False" "High" "IsMasterProtein" "Q92611" "ER degradation-enhancing alpha-mannosidase-like protein 1 OS=Homo sapiens OX=9606 GN=EDEM1 PE=1 SV=1" "0.005" "False" "2.422" "2" "1" "1" "1" "657" "73.7" "6.92" "3.21" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01532" "9695" "ENSG00000134109" "EDEM1" "A8K9C8; B4DXP3; hsa:9695; Q92611" "Photodynamic therapy-induced unfolded protein response" "ER Quality Control Compartment (ERQC); XBP1(S) activates chaperone genes" "3" "0" "1.050" "0.900" "1.089" "1.060" "0.947" "0.992" "0.910" "1.017" "1.033" "116.8" "122.6" "105.1" "127.2" "123.8" "110.6" "115.9" "106.3" "118.8" "120.6" "" "" "" "" "" "" "" "" "" "" "109.5" "101.5" "97.6" "98.3" "105.5" "105.7" "105.9" "94.4" "118.8" "116.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8852376921802983428" "False" "High" "IsMasterProtein" "Q9UN19" "Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide OS=Homo sapiens OX=9606 GN=DAPP1 PE=1 SV=1" "0.005" "False" "2.405" "3" "1" "1" "1" "280" "32.2" "7.80" "2.07" "1" "protein metabolism;other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf00017, Pf00169" "27071" "ENSG00000070190" "DAPP1" "hsa:27071; Q8TCK5; Q9UHF2; Q9UN19" "B cell receptor signaling pathway" "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5479231618500312272" "False" "High" "IsMasterProtein" "Q8NF91" "Nesprin-1 OS=Homo sapiens OX=9606 GN=SYNE1 PE=1 SV=4" "0.005" "False" "2.388" "0" "1" "1" "1" "8797" "1010.5" "5.53" "2.70" "1" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf10541" "23345" "ENSG00000131018" "SYNE1" "B3W695; E7EQI5; H0Y4C0; O94890; Q3ZCV0; Q5JV19; Q5JV22; Q8N9P7; Q8NF91; Q8TCP1; Q8WWW6; Q8WWW7; Q8WXF6; Q96N17; Q9C0A7; Q9H525; Q9H526; Q9NS36; Q9NU50; Q9UJ06; Q9UJ07; Q9ULF8" "Envelope proteins and their potential roles in EDMD physiopathology" "Meiotic synapsis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3154088969782956849" "False" "High" "IsMasterProtein" "Q9NP58" "ATP-binding cassette sub-family B member 6 OS=Homo sapiens OX=9606 GN=ABCB6 PE=1 SV=1" "0.005" "False" "2.381" "1" "1" "1" "1" "842" "93.8" "8.48" "2.05" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf00005, Pf00664, Pf16185" "10058" "ENSG00000115657" "ABCB6" "hsa:10058; O75542; Q49A66; Q59GQ5; Q6ZME6; Q96ME8; Q9HAQ6; Q9HAQ7; Q9NP58" "" "Mitochondrial ABC transporters; Defective ABCB6 causes MCOPCB7" "2" "0" "0.941" "0.964" "0.939" "0.926" "0.961" "0.879" "0.902" "0.961" "1.030" "511.7" "481.5" "493.1" "480.2" "474.0" "491.6" "450.0" "461.7" "491.7" "526.9" "" "" "" "" "" "" "" "" "" "" "479.4" "398.5" "457.7" "371.3" "404.0" "469.6" "411.1" "410.0" "491.7" "507.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2436639350970849740" "False" "High" "IsMasterProtein" "Q9UHB4" "NADPH-dependent diflavin oxidoreductase 1 OS=Homo sapiens OX=9606 GN=NDOR1 PE=1 SV=1" "0.005" "False" "2.381" "2" "1" "1" "1" "597" "66.7" "6.35" "3.49" "1" "cell organization and biogenesis;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00175, Pf00258, Pf00667" "27158" "ENSG00000188566" "NDOR1" "D3YTG6; D3YTH9; hsa:27158; Q5VSG4; Q86US9; Q96BC6; Q9UHB4" "" "Cytosolic iron-sulfur cluster assembly" "1" "0" "1.045" "0.997" "1.125" "1.037" "0.971" "1.072" "0.902" "1.012" "1.041" "155.8" "162.9" "155.3" "175.3" "161.6" "151.3" "167.0" "140.5" "157.7" "162.2" "" "" "" "" "" "" "" "" "" "" "146.0" "134.8" "144.2" "135.5" "137.7" "144.5" "152.6" "124.8" "157.7" "156.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2562963229782590715" "False" "High" "IsMasterProtein" "Q7L7V1" "Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 OS=Homo sapiens OX=9606 GN=DHX32 PE=1 SV=1" "0.005" "False" "2.371" "1" "1" "2" "1" "743" "84.4" "4.97" "2.14" "1" "" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf04408, Pf07717, Pf21010" "55760" "ENSG00000089876" "DHX32" "A8MSV2; D3DRF9; hsa:55760; Q49AG5; Q5T3L0; Q5T3L5; Q7L7V1; Q96NY1; Q9BUN0; Q9H769; Q9NSL5; Q9NV74; Q9NVJ7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3079825360121275387" "False" "High" "IsMasterProtein" "Q5SNV9" "Uncharacterized protein C1orf167 OS=Homo sapiens OX=9606 GN=C1orf167 PE=2 SV=3" "0.005" "False" "2.368" "1" "1" "1" "1" "1449" "160.4" "10.89" "2.53" "1" "" "" "" "Pf15736" "" "" "C1orf167" "A0A8I5KXP5; hsa:284498" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5151232376153751801" "False" "High" "IsMasterProtein" "Q9UIM3" "FK506-binding protein-like OS=Homo sapiens OX=9606 GN=FKBPL PE=1 SV=1" "0.005" "False" "2.362" "3" "1" "1" "1" "349" "38.2" "5.50" "2.16" "1" "other biological processes" "non-structural extracellular;cytosol" "" "Pf00515" "63943" "ENSG00000204315; ENSG00000223666; ENSG00000224200; ENSG00000230907" "FKBPL" "A8K5V3; B0UYX8; hsa:63943; Q9H5G3; Q9UIM3" "" "The role of GTSE1 in G2/M progression after G2 checkpoint" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3879752315455634749" "False" "High" "IsMasterProtein" "O43822" "Cilia- and flagella-associated protein 410 OS=Homo sapiens OX=9606 GN=CFAP410 PE=1 SV=1" "0.005" "False" "2.362" "4" "1" "1" "1" "256" "28.3" "7.34" "2.42" "1" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "" "" "755" "ENSG00000160226" "CFAP410" "A8MPS9; O14993; O43822; Q8N5X6; Q99837; Q99838" "Ciliopathies; Bardet-Biedl syndrome" "" "2" "0" "1.005" "0.985" "0.989" "0.923" "1.062" "0.966" "0.951" "0.937" "1.008" "69.0" "69.3" "68.0" "68.2" "63.6" "73.3" "66.6" "65.6" "64.6" "69.5" "" "" "" "" "" "" "" "" "" "" "64.6" "57.4" "63.1" "52.7" "54.2" "70.0" "60.9" "58.2" "64.6" "66.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9145991611537025162" "False" "High" "IsMasterProtein" "Q16527" "Cysteine and glycine-rich protein 2 OS=Homo sapiens OX=9606 GN=CSRP2 PE=1 SV=3" "0.005" "False" "2.348" "5" "1" "1" "1" "193" "20.9" "8.62" "3.05" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412" "1466" "ENSG00000175183" "CSRP2" "hsa:1466; Q16527; Q93030" "Mesodermal commitment pathway; VEGFA-VEGFR2 signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3674589448003344018" "False" "High" "IsMasterProtein" "Q5T749" "Keratinocyte proline-rich protein OS=Homo sapiens OX=9606 GN=KPRP PE=1 SV=1" "0.006" "False" "2.344" "2" "1" "1" "1" "579" "64.1" "8.27" "2.97" "1" "" "other cell component" "" "" "448834" "ENSG00000203786" "KPRP" "hsa:448834; Q5T749" "" "" "0" "0" "1.168" "0.653" "1.049" "0.901" "0.781" "2.099" "0.812" "0.754" "1.026" "49.9" "58.3" "32.6" "52.3" "45.0" "39.0" "104.7" "40.5" "37.6" "51.2" "" "" "" "" "" "" "" "" "" "" "46.7" "48.2" "30.3" "40.5" "38.3" "37.2" "95.7" "36.0" "37.6" "49.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4337673777992594706" "False" "High" "IsMasterProtein" "Q6NVU6" "Ufm1-specific protease 1 OS=Homo sapiens OX=9606 GN=UFSP1 PE=1 SV=3" "0.006" "False" "2.340" "5" "1" "1" "1" "218" "23.2" "6.11" "3.13" "1" "" "" "" "Pf07910" "" "ENSG00000176125" "UFSP1" "A0A5F9ZGY7" "" "" "0" "0" "1.413" "1.141" "1.247" "1.195" "1.088" "0.969" "1.024" "1.097" "1.093" "128.7" "181.9" "146.9" "160.5" "153.8" "140.0" "124.8" "131.9" "141.1" "140.7" "" "" "" "" "" "" "" "" "" "" "120.6" "150.5" "136.3" "124.1" "131.1" "133.8" "114.0" "117.1" "141.1" "135.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "763377976952146126" "False" "High" "IsMasterProtein" "Q6PF04" "Zinc finger protein 613 OS=Homo sapiens OX=9606 GN=ZNF613 PE=1 SV=2" "0.006" "False" "2.338" "1" "1" "1" "1" "617" "70.1" "8.92" "2.39" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "79898" "ENSG00000176024" "ZNF613" "hsa:79898; Q6PF04; Q96SS9" "" "Generic Transcription Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5071844025737464693" "False" "High" "IsMasterProtein" "O95835" "Serine/threonine-protein kinase LATS1 OS=Homo sapiens OX=9606 GN=LATS1 PE=1 SV=1" "0.006" "False" "2.334" "1" "1" "1" "1" "1130" "126.8" "8.70" "2.79" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433, Pf00627" "9113" "ENSG00000131023" "LATS1" "hsa:9113; O95835; Q6PKD0" "Mesodermal commitment pathway; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Leukocyte-intrinsic Hippo pathway functions; Pleural mesothelioma" "Signaling by Hippo" "9" "0" "1.091" "0.935" "1.060" "1.056" "0.991" "1.071" "0.860" "0.892" "1.059" "130.9" "142.7" "122.3" "138.7" "138.2" "129.7" "140.1" "112.6" "116.7" "138.6" "" "" "" "" "" "" "" "" "" "" "122.6" "118.1" "113.6" "107.3" "117.8" "123.9" "128.0" "100.0" "116.7" "133.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1541658205894384730" "False" "High" "IsMasterProtein" "Q8N8R7" "ARL14 effector protein OS=Homo sapiens OX=9606 GN=ARL14EP PE=1 SV=1" "0.006" "False" "2.333" "3" "1" "2" "1" "260" "29.3" "8.07" "6.10" "1" "" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf14949" "120534" "ENSG00000152219" "ARL14EP" "hsa:120534; Q5HYH9; Q8N8R7" "" "" "0" "0" "1.050" "1.160" "0.995" "1.014" "0.995" "0.998" "0.969" "0.953" "1.014" "232.1" "243.8" "269.2" "231.0" "235.4" "231.1" "231.6" "225.0" "221.2" "235.3" "" "" "" "" "" "" "" "" "" "" "217.5" "201.8" "249.9" "178.6" "200.6" "220.8" "211.6" "199.8" "221.2" "226.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8802052166726839277" "False" "High" "IsMasterProtein" "O75884" "Serine hydrolase RBBP9 OS=Homo sapiens OX=9606 GN=RBBP9 PE=1 SV=2" "0.006" "False" "2.333" "4" "1" "1" "1" "186" "21.0" "6.20" "3.38" "1" "developmental processes;other biological processes" "nucleus" "other molecular function" "Pf06821" "10741" "ENSG00000089050" "RBBP9" "D3DW31; hsa:10741; O75884; Q5JPH9; Q9H1D8" "" "" "0" "0" "1.010" "0.906" "0.940" "0.944" "1.040" "1.093" "0.947" "0.951" "0.950" "147.4" "148.8" "133.5" "138.6" "139.1" "153.3" "161.1" "139.6" "140.2" "140.0" "" "" "" "" "" "" "" "" "" "" "138.1" "123.1" "123.9" "107.1" "118.5" "146.5" "147.2" "124.0" "140.2" "134.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3725331180764852423" "False" "High" "IsMasterProtein" "Q9ULR3" "Protein phosphatase 1H OS=Homo sapiens OX=9606 GN=PPM1H PE=1 SV=2" "0.006" "False" "2.323" "2" "1" "2" "1" "514" "56.4" "6.60" "6.01" "1" "" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00481" "57460" "ENSG00000111110" "PPM1H" "B1Q2A9; B2RXG4; hsa:57460; Q6PI86; Q9ULR3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4219913778501772025" "False" "High" "IsMasterProtein" "Q96PE7" "Methylmalonyl-CoA epimerase, mitochondrial OS=Homo sapiens OX=9606 GN=MCEE PE=1 SV=1" "0.006" "False" "2.323" "7" "1" "2" "1" "176" "18.7" "9.09" "5.42" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf13669" "84693" "ENSG00000124370" "MCEE" "hsa:84693; Q53TP1; Q8WW63; Q96PE7" "Vitamin B12 metabolism" "Propionyl-CoA catabolism" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2824003413195555161" "False" "High" "IsMasterProtein" "A4D0S4" "Laminin subunit beta-4 OS=Homo sapiens OX=9606 GN=LAMB4 PE=1 SV=1" "0.006" "False" "2.317" "0" "1" "1" "1" "1761" "193.4" "6.35" "2.64" "1" "cell adhesion" "non-structural extracellular;extracellular matrix" "" "Pf00053, Pf00055, Pf21199" "22798" "ENSG00000091128" "LAMB4" "A4D0S4; A5PKU6; B2RTT3; B5MEB9; hsa:22798; Q86TP7; Q86XN2; Q8NBX5" "PI3K-Akt signaling pathway; Small cell lung cancer" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5068245923404983933" "False" "High" "IsMasterProtein" "P53671" "LIM domain kinase 2 OS=Homo sapiens OX=9606 GN=LIMK2 PE=1 SV=1" "0.006" "False" "2.316" "1" "1" "1" "1" "638" "72.2" "7.20" "2.10" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00412, Pf00595, Pf07714" "3985" "ENSG00000182541" "LIMK2" "A8K6H5; hsa:3985; P53671; Q7KZ80; Q7L3H5; Q96E10; Q99464; Q9UFU0" "Androgen receptor signaling pathway; TGF-beta signaling pathway; EGF/EGFR signaling pathway" "EPHB-mediated forward signaling; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs" "6" "0" "1.063" "0.969" "1.015" "1.001" "0.904" "0.949" "0.926" "0.768" "0.865" "68.4" "72.7" "66.2" "69.4" "68.4" "61.8" "64.9" "63.3" "52.5" "59.1" "" "" "" "" "" "" "" "" "" "" "64.0" "60.1" "61.5" "53.6" "58.3" "59.1" "59.3" "56.2" "52.5" "56.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8492559823843858039" "False" "High" "IsMasterProtein" "Q6ZW49" "PAX-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAXIP1 PE=1 SV=2" "0.006" "False" "2.313" "1" "1" "1" "1" "1069" "121.3" "6.70" "2.36" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf00533, Pf12738, Pf16589" "22976" "ENSG00000157212" "PAXIP1" "hsa:22976; O15404; Q6N099; Q6ZW49; Q6ZWH9; Q7Z315; Q86UN0; Q8N4P9; Q96HP2" "16p11.2 proximal deletion syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Kleefstra syndrome" "Nonhomologous End-Joining (NHEJ); Activation of anterior HOX genes in hindbrain development during early embryogenesis; Formation of WDR5-containing histone-modifying complexes" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5902665754527388004" "False" "High" "IsMasterProtein" "Q969R8" "KICSTOR complex protein ITFG2 OS=Homo sapiens OX=9606 GN=ITFG2 PE=1 SV=1" "0.006" "False" "2.306" "2" "1" "1" "1" "447" "49.3" "5.22" "0.00" "1" "stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf15907" "55846" "ENSG00000111203" "ITFG2" "A8K4Z5; D3DUQ2; hsa:55846; Q6PKU5; Q969R8; Q96SX6" "" "Amino acids regulate mTORC1" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3789588988762427283" "False" "High" "IsMasterProtein" "Q96FH0" "BLOC-1-related complex subunit 8 OS=Homo sapiens OX=9606 GN=BORCS8 PE=1 SV=1" "0.006" "False" "2.305" "8" "1" "1" "1" "119" "13.4" "5.80" "2.58" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf10167" "729991" "ENSG00000254901" "BORCS8" "B2RXF9; hsa:729991; Q96FH0; Q9BT01" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7979244283854796707" "False" "High" "IsMasterProtein" "Q96S90" "LysM and putative peptidoglycan-binding domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LYSMD1 PE=1 SV=1" "0.006" "False" "2.304" "5" "1" "1" "1" "227" "25.0" "8.57" "2.45" "1" "" "nucleus" "" "Pf01476" "388695" "ENSG00000163155" "LYSMD1" "B4DQA1; hsa:388695; Q69YX9; Q96S90" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8030934540585171981" "False" "High" "IsMasterProtein" "Q9UJT0" "Tubulin epsilon chain OS=Homo sapiens OX=9606 GN=TUBE1 PE=1 SV=1" "0.006" "False" "2.304" "2" "1" "1" "1" "475" "52.9" "6.64" "3.55" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "51175" "ENSG00000074935" "TUBE1" "hsa:51175; Q5H8W8; Q8NEG3; Q9UJT0" "Genes related to primary cilium development (based on CRISPR)" "" "1" "0" "0.882" "1.110" "1.056" "0.903" "0.969" "1.040" "1.036" "0.904" "0.970" "127.0" "112.0" "141.0" "134.2" "114.7" "123.1" "132.1" "131.5" "114.9" "123.2" "" "" "" "" "" "" "" "" "" "" "119.0" "92.7" "130.9" "103.7" "97.8" "117.6" "120.7" "116.8" "114.9" "118.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6222796260561926749" "False" "High" "IsMasterProtein" "Q9NXW2" "DnaJ homolog subfamily B member 12 OS=Homo sapiens OX=9606 GN=DNAJB12 PE=1 SV=5" "0.006" "False" "2.304" "2" "1" "1" "1" "375" "41.8" "8.69" "3.25" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf00226, Pf09320" "54788" "ENSG00000148719" "DNAJB12" "B7Z7I3; hsa:54788; Q9H6H0; Q9NXW2" "" "" "0" "0" "0.952" "0.868" "0.968" "0.952" "0.933" "1.155" "1.065" "0.952" "1.003" "126.6" "120.5" "110.0" "122.5" "120.6" "118.1" "146.2" "134.9" "120.5" "127.0" "" "" "" "" "" "" "" "" "" "" "118.6" "99.7" "102.1" "94.7" "102.8" "112.8" "133.6" "119.8" "120.5" "122.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7908079185192483938" "False" "High" "IsMasterProtein" "P49716" "CCAAT/enhancer-binding protein delta OS=Homo sapiens OX=9606 GN=CEBPD PE=1 SV=2" "0.006" "False" "2.300" "3" "1" "1" "1" "269" "28.4" "8.28" "3.22" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07716" "1052" "ENSG00000221869" "CEBPD" "hsa:1052; P49716; Q14937; Q2M2X9" "IL-17 signaling pathway; Adipogenesis; MECP2 and associated Rett syndrome; Transcription factor regulation in adipogenesis; White fat cell differentiation; Transcriptional cascade regulating adipogenesis; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "Transcriptional regulation of white adipocyte differentiation; HCMV Late Events; Interleukin-4 and Interleukin-13 signaling" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3528927325203827381" "False" "High" "IsMasterProtein" "Q9H2X9" "Solute carrier family 12 member 5 OS=Homo sapiens OX=9606 GN=SLC12A5 PE=1 SV=3" "0.006" "False" "2.291" "1" "1" "1" "1" "1139" "126.1" "6.73" "2.53" "1" "cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;other molecular function" "Pf00324, Pf03522" "57468" "ENSG00000124140" "SLC12A5" "A2RTX2; hsa:57468; Q5VZ41; Q9H2X9; Q9H4Z0; Q9ULP4" "mBDNF and proBDNF regulation of GABA neurotransmission" "Cation-coupled Chloride cotransporters" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4759228075821596448" "False" "High" "IsMasterProtein" "Q8IZD2" "Inactive histone-lysine N-methyltransferase 2E OS=Homo sapiens OX=9606 GN=KMT2E PE=1 SV=1" "0.006" "False" "2.289" "0" "1" "1" "1" "1858" "204.8" "7.61" "2.44" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00856, Pf20826" "55904" "ENSG00000005483" "KMT2E" "B6ZDE4; B6ZDM3; hsa:55904; M4K8J3; Q6P5Y2; Q6PKG4; Q6T316; Q86TI3; Q86W12; Q86WG0; Q86WL2; Q8IV78; Q8IWR5; Q8IZD2; Q8NFF8; Q9NWE7" "Histone modifications" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1862365170183324257" "False" "High" "IsMasterProtein" "P56182" "Ribosomal RNA processing protein 1 homolog A OS=Homo sapiens OX=9606 GN=RRP1 PE=1 SV=1" "0.006" "False" "2.289" "3" "1" "1" "1" "461" "52.8" "9.33" "2.23" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf05997" "8568" "ENSG00000160214" "RRP1" "hsa:8568; P56182; Q9NST5" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2714987798271116551" "False" "High" "IsMasterProtein" "Q9BUE0" "Mediator of RNA polymerase II transcription subunit 18 OS=Homo sapiens OX=9606 GN=MED18 PE=1 SV=1" "0.006" "False" "2.280" "4" "1" "1" "1" "208" "23.6" "6.54" "2.52" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09637" "54797" "ENSG00000130772; ENSG00000284944" "MED18" "D3DPM1; hsa:54797; Q9BUE0; Q9NXU9" "" "Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; RSV-host interactions" "3" "0" "0.967" "1.059" "1.145" "1.154" "1.153" "1.151" "1.139" "1.173" "1.123" "109.7" "106.0" "116.2" "125.6" "126.6" "126.5" "126.2" "124.9" "128.6" "123.2" "" "" "" "" "" "" "" "" "" "" "102.8" "87.8" "107.9" "97.1" "107.9" "120.8" "115.3" "110.9" "128.6" "118.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7100203530818565223" "False" "High" "IsMasterProtein" "O00443" "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha OS=Homo sapiens OX=9606 GN=PIK3C2A PE=1 SV=2" "0.006" "False" "2.271" "0" "1" "1" "1" "1686" "190.6" "8.02" "3.03" "1" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00168, Pf00454, Pf00613, Pf00787, Pf00792, Pf00794" "5286" "ENSG00000011405" "PIK3C2A" "B0LPH2; B4E2G4; hsa:5286; O00443; Q14CQ9" "Glioblastoma signaling pathways; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Osteoblast differentiation and related diseases; Insulin signaling; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)" "Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3311926917854502333" "False" "High" "IsMasterProtein" "O43414" "ERI1 exoribonuclease 3 OS=Homo sapiens OX=9606 GN=ERI3 PE=1 SV=2" "0.006" "False" "2.271" "3" "1" "1" "1" "337" "37.2" "8.07" "2.28" "1" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00929" "79033" "ENSG00000117419" "ERI3" "B1AK98; hsa:79033; O43414; Q5T2T7; Q5T2T9; Q5TG35; Q9BQA0; Q9UEB4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3307427478696066462" "False" "High" "IsMasterProtein" "Q96AJ9" "Vesicle transport through interaction with t-SNAREs homolog 1A OS=Homo sapiens OX=9606 GN=VTI1A PE=1 SV=2" "0.006" "False" "2.269" "4" "1" "1" "1" "217" "25.2" "6.40" "2.11" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05008, Pf12352" "143187" "ENSG00000151532" "VTI1A" "A2A307; B4E137; hsa:143187; Q5W0D7; Q96AJ9" "" "Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5394846730023349610" "False" "High" "IsMasterProtein" "P55081" "Microfibrillar-associated protein 1 OS=Homo sapiens OX=9606 GN=MFAP1 PE=1 SV=2" "0.006" "False" "2.268" "2" "1" "1" "1" "439" "51.9" "4.98" "2.66" "1" "RNA metabolism OR transcription;other metabolic processes" "extracellular matrix;cytoskeleton;nucleus" "" "Pf06991" "4236" "ENSG00000140259" "MFAP1" "hsa:4236; P55081; Q86TG6" "Canonical and non-canonical Notch signaling; Ciliary landscape" "mRNA Splicing - Major Pathway" "3" "0" "1.035" "0.943" "1.060" "1.097" "1.039" "1.074" "0.960" "0.820" "0.765" "263.4" "272.6" "248.3" "279.1" "289.1" "273.7" "282.9" "253.0" "216.1" "201.4" "" "" "" "" "" "" "" "" "" "" "246.8" "225.6" "230.5" "215.8" "246.4" "261.5" "258.5" "224.7" "216.1" "194.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1379432049065423837" "False" "High" "IsMasterProtein" "O75143" "Autophagy-related protein 13 OS=Homo sapiens OX=9606 GN=ATG13 PE=1 SV=1" "0.006" "False" "2.254" "2" "1" "2" "1" "517" "56.5" "5.12" "3.85" "1" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf10033" "9776" "ENSG00000175224" "ATG13" "B4DFI4; D3DQQ1; D3DQQ2; E9PQZ8; hsa:9776; O75143; Q53EN6; Q9BRL3; Q9H8B0" "Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Host-pathogen interaction of human coronaviruses - autophagy; Autophagy; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4970253198694079027" "False" "High" "IsMasterProtein" "Q96BW1" "Uracil phosphoribosyltransferase homolog OS=Homo sapiens OX=9606 GN=UPRT PE=1 SV=1" "0.006" "False" "2.252" "3" "1" "1" "1" "309" "33.8" "6.04" "1.66" "1" "other metabolic processes;transport;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf14681" "139596" "ENSG00000094841" "UPRT" "hsa:139596; Q5JRL1; Q5JRL3; Q68DN0; Q96BW1; Q96MW2" "Pyrimidine metabolism" "" "1" "0" "1.126" "1.103" "1.062" "1.076" "0.987" "1.181" "1.155" "1.122" "1.033" "134.4" "151.3" "148.2" "142.7" "144.6" "132.6" "158.7" "155.3" "150.8" "138.8" "" "" "" "" "" "" "" "" "" "" "125.9" "125.2" "137.6" "110.3" "123.2" "126.7" "145.0" "137.9" "150.8" "133.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8013178931392780313" "False" "High" "IsMasterProtein" "Q9H6V9" "Lipid droplet-associated hydrolase OS=Homo sapiens OX=9606 GN=LDAH PE=1 SV=1" "0.006" "False" "2.250" "3" "1" "1" "1" "325" "37.3" "6.54" "2.31" "1" "other metabolic processes;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf10230" "60526" "ENSG00000118961" "LDAH" "B7ZA47; B7ZAJ5; D6W530; E7ESN0; hsa:60526; Q53T37; Q53T58; Q9H6V9" "" "" "0" "0" "1.446" "1.072" "1.586" "1.421" "1.222" "1.262" "1.042" "1.103" "1.026" "31.5" "45.6" "33.8" "50.0" "44.8" "38.5" "39.8" "32.9" "34.8" "32.4" "" "" "" "" "" "" "" "" "" "" "29.5" "37.7" "31.4" "38.7" "38.2" "36.8" "36.3" "29.2" "34.8" "31.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1194949303264127271" "False" "High" "IsMasterProtein" "Q9NUA8" "Zinc finger and BTB domain-containing protein 40 OS=Homo sapiens OX=9606 GN=ZBTB40 PE=1 SV=4" "0.006" "False" "2.244" "1" "1" "1" "1" "1239" "138.0" "6.57" "2.67" "1" "stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651, Pf12874" "9923" "ENSG00000184677" "ZBTB40" "hsa:9923; O75066; Q5TFU5; Q8N1R1; Q9NUA8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "672780113730382771" "False" "High" "IsMasterProtein" "Q99952" "Tyrosine-protein phosphatase non-receptor type 18 OS=Homo sapiens OX=9606 GN=PTPN18 PE=1 SV=2" "0.006" "False" "2.244" "3" "1" "2" "1" "460" "50.5" "8.25" "6.37" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00102" "26469" "ENSG00000072135" "PTPN18" "B4E1E6; hsa:26469; Q53P42; Q99952" "B cell receptor signaling pathway" "Downregulation of ERBB2 signaling; Interleukin-37 signaling" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2027123753413932420" "False" "High" "IsMasterProtein" "Q8NBN7" "Retinol dehydrogenase 13 OS=Homo sapiens OX=9606 GN=RDH13 PE=1 SV=2" "0.006" "False" "2.243" "3" "1" "2" "1" "331" "35.9" "8.10" "7.13" "1" "other metabolic processes;developmental processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00106" "112724" "ENSG00000160439; ENSG00000273944; ENSG00000274418; ENSG00000274504; ENSG00000275474; ENSG00000276341; ENSG00000276684; ENSG00000276826; ENSG00000278149; ENSG00000278284" "RDH13" "Q6UX79; Q8NBN7; Q96G88" "" "RA biosynthesis pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4949581647878709913" "False" "High" "IsMasterProtein" "Q7Z7A1" "Centriolin OS=Homo sapiens OX=9606 GN=CNTRL PE=1 SV=2" "0.006" "False" "2.242" "0" "1" "1" "1" "2325" "268.7" "5.55" "2.06" "1" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf14580" "11064" "ENSG00000119397" "CNTRL" "A2A2Y1; B2RP67; hsa:11064; Q3MN79; Q5FWF8; Q5JVD0; Q6MZR3; Q6PKC1; Q7Z7A1; Q8TEP3; Q9Y489" "" "Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3152037375536322199" "False" "High" "IsMasterProtein" "P68402" "Platelet-activating factor acetylhydrolase IB subunit alpha2 OS=Homo sapiens OX=9606 GN=PAFAH1B2 PE=1 SV=1" "0.006" "False" "2.237" "4" "1" "1" "1" "229" "25.6" "5.92" "2.71" "1" "other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf13472" "5049" "ENSG00000168092" "PAFAH1B2" "A8DPS5; A8DPS6; A8DPS7; E9PEJ5; E9PLP3; hsa:5049; O00687; P68402; Q29459; Q6IBR6" "PAFAH1B1 copy number variation" "COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4372150383973337968" "False" "High" "IsMasterProtein" "Q96AY4" "Tetratricopeptide repeat protein 28 OS=Homo sapiens OX=9606 GN=TTC28 PE=1 SV=4" "0.006" "False" "2.235" "0" "1" "1" "1" "2481" "270.7" "6.89" "2.50" "1" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf12770, Pf13176, Pf13424" "23331" "ENSG00000100154" "TTC28" "hsa:23331; K7ZRV2; O95928; O95929; Q5W189; Q96AY4; Q9NTE4; Q9UG31; Q9UGG5; Q9UPV8; Q9Y3S5" "" "" "0" "0" "1.155" "0.900" "1.246" "1.013" "0.883" "0.991" "0.981" "0.901" "0.915" "90.2" "104.1" "81.1" "112.3" "91.3" "79.6" "89.4" "88.4" "81.2" "82.5" "" "" "" "" "" "" "" "" "" "" "84.5" "86.2" "75.3" "86.8" "77.9" "76.0" "81.6" "78.5" "81.2" "79.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5885254063310961994" "False" "High" "IsMasterProtein" "Q6NXT1" "Ankyrin repeat domain-containing protein 54 OS=Homo sapiens OX=9606 GN=ANKRD54 PE=1 SV=2" "0.007" "False" "2.220" "3" "1" "1" "1" "300" "32.5" "6.28" "3.24" "1" "transport;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf12796" "129138" "ENSG00000100124" "ANKRD54" "hsa:129138; Q6NXT1; Q6ZSB1; Q9UGV1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2300421444410781361" "False" "High" "IsMasterProtein" "Q9BRP1" "Programmed cell death protein 2-like OS=Homo sapiens OX=9606 GN=PDCD2L PE=1 SV=1" "0.007" "False" "2.218" "2" "1" "1" "1" "358" "39.4" "4.86" "2.72" "1" "cell cycle OR cell proliferation;other biological processes" "other cell component" "" "Pf04194" "84306" "ENSG00000126249" "PDCD2L" "hsa:84306; Q9BRP1" "" "" "0" "0" "1.077" "1.034" "1.089" "1.078" "1.136" "0.967" "1.082" "1.062" "1.100" "322.7" "347.7" "333.8" "351.4" "348.0" "366.6" "311.9" "349.1" "342.8" "355.0" "" "" "" "" "" "" "" "" "" "" "302.4" "287.8" "309.9" "271.7" "296.6" "350.3" "285.0" "310.0" "342.8" "341.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2029862218257081345" "False" "High" "IsMasterProtein" "O15318" "DNA-directed RNA polymerase III subunit RPC7 OS=Homo sapiens OX=9606 GN=POLR3G PE=1 SV=2" "0.007" "False" "2.217" "5" "1" "1" "1" "223" "25.9" "4.63" "3.90" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "other molecular function" "Pf11705" "10622" "ENSG00000113356" "POLR3G" "A8MTH0; hsa:10622; O15318" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; TAR syndrome" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "1.034" "0.954" "1.098" "0.914" "0.940" "1.004" "0.933" "0.908" "0.982" "136.8" "141.4" "130.5" "150.3" "125.1" "128.6" "137.3" "127.7" "124.2" "134.4" "" "" "" "" "" "" "" "" "" "" "128.2" "117.0" "121.1" "116.2" "106.6" "122.8" "125.5" "113.3" "124.2" "129.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6721724367357589607" "False" "High" "IsMasterProtein" "Q6IPU0" "Centromere protein P OS=Homo sapiens OX=9606 GN=CENPP PE=1 SV=1" "0.007" "False" "2.210" "3" "1" "1" "1" "288" "33.1" "6.27" "2.03" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf13096" "401541" "ENSG00000188312; ENSG00000291348" "CENPP" "B3KRA5; B3KS17; hsa:401541; Q5T9F8; Q5T9F9; Q6IPU0" "" "Deposition of new CENPA-containing nucleosomes at the centromere; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "0.972" "1.003" "1.067" "1.185" "0.916" "1.121" "1.093" "1.024" "1.067" "176.4" "171.5" "177.0" "188.2" "209.0" "161.6" "197.8" "192.8" "180.7" "188.3" "" "" "" "" "" "" "" "" "" "" "165.3" "141.9" "164.3" "145.5" "178.1" "154.4" "180.7" "171.2" "180.7" "181.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7612654384258451191" "False" "High" "IsMasterProtein" "Q13571" "Lysosomal-associated transmembrane protein 5 OS=Homo sapiens OX=9606 GN=LAPTM5 PE=1 SV=1" "0.007" "False" "2.193" "6" "1" "1" "1" "262" "29.9" "8.68" "2.76" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03821" "7805" "ENSG00000162511" "LAPTM5" "hsa:7805; Q13240; Q13571; Q14698; Q3KP54" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3433640021068087634" "False" "High" "IsMasterProtein" "Q8N1G0" "Zinc finger protein 687 OS=Homo sapiens OX=9606 GN=ZNF687 PE=1 SV=1" "0.007" "False" "2.193" "1" "1" "1" "1" "1237" "129.4" "8.19" "2.44" "1" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf16622" "57592" "ENSG00000143373" "ZNF687" "D3DV17; hsa:57592; Q68DQ8; Q8N1G0; Q9H937; Q9P2A7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5023759696218809409" "False" "High" "IsMasterProtein" "Q7Z434" "Mitochondrial antiviral-signaling protein OS=Homo sapiens OX=9606 GN=MAVS PE=1 SV=2" "0.007" "False" "2.185" "3" "1" "2" "1" "540" "56.5" "5.52" "5.16" "1" "stress response;signal transduction;other biological processes" "other membranes;mitochondrion;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf16739" "57506" "ENSG00000088888" "MAVS" "A8K6X0; B2BD33; B2BD34; F5H6C8; hsa:57506; M1P2Z0; Q2HWT5; Q3I0Y2; Q5T7I6; Q7Z434; Q86VY7; Q9H1H3; Q9H4Y1; Q9H8D3; Q9ULE9" "Novel intracellular components of RIG-I-like receptor pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "TRAF6 mediated NF-kB activation; SARS-CoV-1 activates/modulates innate immune responses; PKR-mediated signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses" "24" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3780943028693763467" "False" "High" "IsMasterProtein" "Q9H009" "Nascent polypeptide-associated complex subunit alpha-2 OS=Homo sapiens OX=9606 GN=NACA2 PE=1 SV=1" "0.007" "False" "2.182" "4" "1" "1" "1" "215" "23.2" "4.73" "2.55" "1" "other biological processes" "translational apparatus;nucleus;other cell component" "other molecular function" "Pf01849, Pf19026" "342538" "ENSG00000253506" "NACA2" "hsa:342538; Q2VIR9; Q9H009" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1787122580300453295" "False" "High" "IsMasterProtein" "Q5HYC2" "Uncharacterized bromodomain-containing protein 10 OS=Homo sapiens OX=9606 GN=BRD10 PE=1 SV=2" "0.007" "False" "2.176" "0" "1" "1" "1" "2103" "227.9" "9.04" "0.00" "1" "" "" "" "Pf00439" "158358" "ENSG00000183354" "KIAA2026" "A8MTP2; B9EGW7; hsa:158358; Q4VXA2; Q5HYC2; Q8IVE5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3143696315815793188" "False" "High" "IsMasterProtein" "Q8WXH0" "Nesprin-2 OS=Homo sapiens OX=9606 GN=SYNE2 PE=1 SV=3" "0.007" "False" "2.173" "0" "1" "1" "1" "6885" "795.9" "5.36" "1.98" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf10541" "23224" "ENSG00000054654" "SYNE2" "B4DND7; B4DPR6; I6XXQ5; Q540G1; Q86YP9; Q8N1S3; Q8NF49; Q8TER7; Q8WWW3; Q8WWW4; Q8WWW5; Q8WXH0; Q8WXH1; Q9NU50; Q9UFQ4; Q9Y2L4; Q9Y4R1" "Ovarian infertility; Rett syndrome; Envelope proteins and their potential roles in EDMD physiopathology" "Meiotic synapsis" "4" "0" "1.083" "1.147" "1.384" "1.304" "1.169" "1.615" "1.338" "1.267" "1.183" "54.4" "59.0" "62.4" "75.3" "71.0" "63.6" "87.9" "72.9" "69.0" "64.4" "" "" "" "" "" "" "" "" "" "" "51.0" "48.8" "58.0" "58.2" "60.5" "60.8" "80.4" "64.7" "69.0" "62.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1117159967779804568" "False" "High" "IsMasterProtein" "Q7L4I2" "Arginine/serine-rich coiled-coil protein 2 OS=Homo sapiens OX=9606 GN=RSRC2 PE=1 SV=1" "0.007" "False" "2.169" "2" "1" "1" "1" "434" "50.5" "11.33" "2.94" "1" "" "" "" "Pf15477" "65117" "ENSG00000111011" "RSRC2" "hsa:65117; Q6N040; Q6NW16; Q7L4I2; Q9H864" "" "" "0" "0" "0.995" "0.940" "0.928" "0.871" "0.892" "0.715" "0.699" "0.773" "0.847" "331.8" "330.3" "311.8" "307.8" "289.0" "295.9" "237.3" "231.9" "256.7" "280.9" "" "" "" "" "" "" "" "" "" "" "310.9" "273.3" "289.4" "237.9" "246.3" "282.7" "216.8" "205.9" "256.7" "270.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9042587910182290108" "False" "High" "IsMasterProtein" "Q8IZM8" "Zinc finger protein 654 OS=Homo sapiens OX=9606 GN=ZNF654 PE=1 SV=4" "0.007" "False" "2.166" "1" "1" "1" "1" "1128" "127.8" "5.27" "3.08" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "" "ENSG00000175105" "ZNF654" "A0A1B0GWA0; Q8IZM8; Q9H791; Q9NV14" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8425175822669482526" "False" "High" "IsMasterProtein" "Q9NRY5" "Protein FAM114A2 OS=Homo sapiens OX=9606 GN=FAM114A2 PE=1 SV=4" "0.007" "False" "2.164" "2" "1" "1" "1" "505" "55.4" "4.88" "1.61" "1" "" "" "other molecular function" "Pf05334" "10827" "ENSG00000055147" "FAM114A2" "B2R8D8; hsa:10827; Q9H7E0; Q9NRY5" "" "Signaling by BRAF and RAF1 fusions" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1805592529693250649" "False" "High" "IsMasterProtein" "Q9BYE7" "Polycomb group RING finger protein 6 OS=Homo sapiens OX=9606 GN=PCGF6 PE=1 SV=2" "0.007" "False" "2.162" "2" "1" "2" "1" "350" "39.0" "4.97" "5.38" "1" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf13923, Pf16207" "84108" "ENSG00000156374" "PCGF6" "A8K3R4; hsa:84108; Q5SYD1; Q5SYD6; Q96ID9; Q96SJ1; Q9BYE7" "" "Transcriptional Regulation by E2F6" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9041670959328439504" "False" "High" "IsMasterProtein" "Q13487" "snRNA-activating protein complex subunit 2 OS=Homo sapiens OX=9606 GN=SNAPC2 PE=1 SV=1" "0.007" "False" "2.161" "2" "1" "1" "1" "334" "35.5" "6.01" "2.78" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf11035" "6618" "ENSG00000104976" "SNAPC2" "B2RBZ6; D6W663; hsa:6618; Q13486; Q13487" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes" "3" "0" "1.021" "1.204" "1.127" "1.217" "1.113" "1.063" "1.144" "1.155" "1.170" "100.1" "102.2" "120.5" "112.8" "121.9" "111.5" "106.5" "114.6" "115.7" "117.2" "" "" "" "" "" "" "" "" "" "" "93.8" "84.6" "111.9" "87.2" "103.9" "106.5" "97.3" "101.8" "115.7" "112.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1462166031620212631" "False" "High" "IsMasterProtein" "Q12882" "Dihydropyrimidine dehydrogenase [NADP(+)] OS=Homo sapiens OX=9606 GN=DPYD PE=1 SV=2" "0.007" "False" "2.161" "1" "1" "1" "1" "1025" "111.3" "7.05" "1.75" "1" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01180, Pf07992, Pf14691, Pf14697" "1806" "ENSG00000188641" "DPYD" "A2RRQ2; A2RRQ3; A8K5A2; A8MWG9; B1AN21; E9PFN1; hsa:1806; Q12882; Q16694; Q16761; Q32NB0; Q96HL6; Q96TH1" "Fluoropyrimidine activity; TYROBP causal network in microglia; Pyrimidine metabolism" "Pyrimidine catabolism" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1851895085695253259" "False" "High" "IsMasterProtein" "Q14865" "AT-rich interactive domain-containing protein 5B OS=Homo sapiens OX=9606 GN=ARID5B PE=1 SV=3" "0.008" "False" "2.161" "1" "1" "1" "1" "1188" "132.3" "8.72" "3.18" "1" "other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01388" "84159" "ENSG00000150347" "ARID5B" "B4DLB3; hsa:84159; Q05DG6; Q14865; Q32Q59; Q5VST4; Q6NZ42; Q7Z3M4; Q8N421; Q9H786" "Mesodermal commitment pathway; FTO obesity variant mechanism; Pathways affected in adenoid cystic carcinoma" "HDMs demethylate histones" "4" "0" "1.001" "0.956" "1.185" "1.016" "0.957" "1.134" "1.043" "0.938" "1.088" "49.6" "49.6" "47.4" "58.8" "50.4" "47.5" "56.3" "51.7" "46.6" "54.0" "" "" "" "" "" "" "" "" "" "" "46.5" "41.1" "44.0" "45.4" "43.0" "45.3" "51.4" "45.9" "46.6" "52.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7013098245942053338" "False" "High" "IsMasterProtein" "Q8IWT3" "Cullin-9 OS=Homo sapiens OX=9606 GN=CUL9 PE=1 SV=2" "0.008" "False" "2.160" "0" "1" "1" "1" "2517" "281.0" "5.45" "2.10" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00888, Pf01485, Pf03256, Pf11515" "23113" "ENSG00000112659" "CUL9" "hsa:23113; O75188; Q5TCY3; Q68CP2; Q68D92; Q8IWT3; Q8N3W9; Q9BU56" "" "Neddylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3430961605673792526" "False" "High" "IsMasterProtein" "Q13033" "Striatin-3 OS=Homo sapiens OX=9606 GN=STRN3 PE=1 SV=3" "0.008" "False" "2.159" "1" "1" "2" "1" "797" "87.2" "5.36" "5.96" "1" "other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00400, Pf08232" "29966" "ENSG00000196792" "STRN3" "A2RTX7; A6NHZ7; hsa:29966; Q13033; Q9NRA5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6717347442497409014" "False" "High" "IsMasterProtein" "Q9NXF7" "DDB1- and CUL4-associated factor 16 OS=Homo sapiens OX=9606 GN=DCAF16 PE=1 SV=1" "0.008" "False" "2.154" "4" "1" "1" "1" "216" "24.2" "6.04" "3.08" "1" "protein metabolism;other metabolic processes" "nucleus;other cell component" "" "Pf15349" "54876" "ENSG00000163257" "DCAF16" "B3KPB7; hsa:54876; Q9NXF7" "" "Neddylation" "1" "0" "1.000" "0.947" "0.946" "0.942" "1.057" "0.908" "0.914" "0.945" "0.963" "296.1" "296.0" "280.3" "280.2" "278.9" "313.1" "269.0" "270.7" "279.7" "285.1" "" "" "" "" "" "" "" "" "" "" "277.5" "244.9" "260.2" "216.6" "237.8" "299.2" "245.8" "240.4" "279.7" "274.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2318951358478494228" "False" "High" "IsMasterProtein" "Q8WW01" "tRNA-splicing endonuclease subunit Sen15 OS=Homo sapiens OX=9606 GN=TSEN15 PE=1 SV=1" "0.008" "False" "2.152" "9" "1" "1" "1" "171" "18.6" "4.58" "1.73" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf09631" "116461" "ENSG00000198860" "TSEN15" "B4DKP0; hsa:116461; Q8WW01; Q9BZQ5" "" "tRNA processing in the nucleus" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7610728054593455927" "False" "High" "IsMasterProtein" "Q86SZ2" "Trafficking protein particle complex subunit 6B OS=Homo sapiens OX=9606 GN=TRAPPC6B PE=1 SV=1" "0.008" "False" "2.150" "6" "1" "1" "1" "158" "18.0" "8.68" "0.00" "1" "cell organization and biogenesis;transport;developmental processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "122553" "ENSG00000182400" "TRAPPC6B" "B3KPS2; hsa:122553; Q5JPD6; Q86SZ2; Q86U35; Q86X35" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "1.278" "0.894" "1.863" "1.185" "0.685" "1.397" "0.900" "0.704" "0.914" "139.7" "178.7" "125.0" "260.3" "165.6" "95.7" "195.2" "125.8" "98.4" "127.7" "" "" "" "" "" "" "" "" "" "" "130.9" "147.8" "116.0" "201.2" "141.2" "91.5" "178.4" "111.7" "98.4" "122.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4282348834355935328" "False" "High" "IsMasterProtein" "Q8IWW6" "Rho GTPase-activating protein 12 OS=Homo sapiens OX=9606 GN=ARHGAP12 PE=1 SV=1" "0.008" "False" "2.136" "1" "1" "1" "1" "846" "96.2" "7.61" "3.21" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other cell component" "enzyme regulator activity" "Pf00018, Pf00169, Pf00397, Pf00620, Pf16618" "94134" "ENSG00000165322" "ARHGAP12" "B1ANY0; B1ANY1; B1ANY2; hsa:94134; Q504X1; Q86UB3; Q8IWW6; Q8IWW7; Q8N3L1; Q9NT76" "" "RAC1 GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; RHOV GTPase cycle" "4" "0" "1.059" "0.900" "0.980" "1.179" "1.259" "1.138" "1.059" "0.976" "1.014" "64.7" "68.5" "58.2" "63.4" "76.2" "81.4" "73.6" "68.5" "63.1" "65.6" "" "" "" "" "" "" "" "" "" "" "60.6" "56.7" "54.0" "49.0" "65.0" "77.8" "67.2" "60.8" "63.1" "63.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6372570130755295238" "False" "High" "IsMasterProtein" "Q5XUX0" "F-box only protein 31 OS=Homo sapiens OX=9606 GN=FBXO31 PE=1 SV=2" "0.008" "False" "2.135" "3" "1" "1" "1" "539" "60.6" "7.02" "2.07" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction" "cytosol;other cell component" "other molecular function" "Pf12014, Pf12937" "79791" "ENSG00000103264" "FBXO31" "hsa:79791; Q5K680; Q5XUX0; Q8WYV1; Q96D73; Q9UFV4" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.225" "1.147" "1.287" "1.116" "1.115" "1.197" "1.007" "1.140" "0.843" "11.1" "13.6" "12.7" "14.3" "12.4" "12.4" "13.3" "11.2" "12.7" "9.4" "" "" "" "" "" "" "" "" "" "" "10.4" "11.3" "11.8" "11.1" "10.6" "11.8" "12.2" "9.9" "12.7" "9.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4490493578304001377" "False" "High" "IsMasterProtein" "Q92830" "Histone acetyltransferase KAT2A OS=Homo sapiens OX=9606 GN=KAT2A PE=1 SV=3" "0.008" "False" "2.133" "1" "1" "1" "1" "837" "93.9" "9.04" "2.80" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00439, Pf00583, Pf06466" "2648" "ENSG00000108773" "KAT2A" "hsa:2648; Q8N1A2; Q92830; Q9UCW1" "Notch signaling" "Ub-specific processing proteases; B-WICH complex positively regulates rRNA expression; Pre-NOTCH Transcription and Translation; HATs acetylate histones; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling; Formation of WDR5-containing histone-modifying complexes; RNA Polymerase I Transcription Initiation; Cardiogenesis" "17" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2256446173199490413" "False" "High" "IsMasterProtein" "P63128" "Endogenous retrovirus group K member 9 Pol protein OS=Homo sapiens OX=9606 GN=ERVK-9 PE=1 SV=3" "0.008" "False" "2.122" "1" "1" "1" "1" "1117" "123.5" "8.87" "2.21" "1" "protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes" "nucleic acid binding activity;other molecular function" "Pf00077, Pf00078, Pf00098, Pf00607, Pf00692, Pf01585, Pf02337, Pf14787, Pf19317" "" "" "ERVK-9" "P63128; Q9UKH4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7628983176653617148" "False" "High" "IsMasterProtein" "Q9UI47" "Catenin alpha-3 OS=Homo sapiens OX=9606 GN=CTNNA3 PE=1 SV=2" "0.008" "False" "2.121" "1" "1" "1" "1" "895" "99.7" "6.16" "2.26" "1" "cell adhesion;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01044" "29119" "ENSG00000183230" "CTNNA3" "hsa:29119; Q5VSR2; Q6P056; Q9UI47" "Arrhythmogenic right ventricular cardiomyopathy; Endometrial cancer; Pleural mesothelioma" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7185396298341420478" "False" "High" "IsMasterProtein" "Q13601" "KRR1 small subunit processome component homolog OS=Homo sapiens OX=9606 GN=KRR1 PE=1 SV=4" "0.008" "False" "2.121" "2" "1" "1" "1" "381" "43.6" "9.77" "2.88" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf17903, Pf21800" "11103" "ENSG00000111615" "KRR1" "A0FIK6; A0JLP0; B2R989; E7EUQ0; hsa:11103; Q13601; Q8NEA8; Q8TC37; Q96AT5" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3969710029576412220" "False" "High" "IsMasterProtein" "Q9Y3T6" "R3H and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=R3HCC1 PE=1 SV=3" "0.008" "False" "2.114" "2" "1" "1" "1" "440" "49.1" "5.63" "2.46" "1" "" "" "nucleic acid binding activity" "Pf01424" "203069" "ENSG00000104679" "R3HCC1" "B7ZLI1; hsa:203069; Q9Y3T6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7903572994601535827" "False" "High" "IsMasterProtein" "Q9Y6N5" "Sulfide:quinone oxidoreductase, mitochondrial OS=Homo sapiens OX=9606 GN=SQOR PE=1 SV=1" "0.008" "False" "2.113" "3" "1" "1" "1" "450" "49.9" "9.11" "2.16" "1" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf07992" "58472" "ENSG00000137767" "SQOR" "hsa:58472; Q9UQM8; Q9Y6N5" "" "Sulfide oxidation to sulfate" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8713380436033100522" "False" "High" "IsMasterProtein" "Q71SY5" "Mediator of RNA polymerase II transcription subunit 25 OS=Homo sapiens OX=9606 GN=MED25 PE=1 SV=2" "0.008" "False" "2.112" "1" "1" "1" "1" "747" "78.1" "8.34" "3.05" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11232, Pf11235, Pf11265" "81857" "ENSG00000104973" "MED25" "A8K095; B9TX30; hsa:81857; O95783; Q6P143; Q6QMH5; Q707U4; Q71SY5; Q8TB55; Q9H0L5; Q9HB34" "" "Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7106533515535511067" "False" "High" "IsMasterProtein" "Q969E8" "Pre-rRNA-processing protein TSR2 homolog OS=Homo sapiens OX=9606 GN=TSR2 PE=1 SV=1" "0.008" "False" "2.105" "4" "1" "2" "1" "191" "20.9" "4.39" "5.24" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf10273" "90121" "ENSG00000158526" "TSR2" "hsa:90121; Q969E8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3934808494784224808" "False" "High" "IsMasterProtein" "Q96FJ2" "Dynein light chain 2, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL2 PE=1 SV=1" "0.009" "False" "2.094" "8" "1" "1" "1" "89" "10.3" "7.37" "3.32" "1" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf01221" "140735" "ENSG00000264364" "DYNLL2" "B2R5B4; hsa:140735; Q96FJ2" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome; Vasopressin-regulated water reabsorption" "Separation of Sister Chromatids; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; HCMV Early Events; Intraflagellar transport; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Macroautophagy; Activation of BMF and translocation to mitochondria" "19" "0" "0.891" "1.014" "0.824" "0.882" "1.039" "0.817" "1.102" "1.056" "0.956" "403.9" "359.7" "409.6" "333.0" "356.2" "419.7" "330.0" "445.1" "426.7" "386.3" "" "" "" "" "" "" "" "" "" "" "378.4" "297.7" "380.2" "257.4" "303.6" "401.0" "301.5" "395.2" "426.7" "371.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2974291959383986730" "False" "High" "IsMasterProtein" "Q9UL33" "Trafficking protein particle complex subunit 2-like protein OS=Homo sapiens OX=9606 GN=TRAPPC2L PE=1 SV=1" "0.009" "False" "2.094" "6" "1" "1" "1" "140" "16.1" "6.77" "2.45" "1" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04628" "51693" "ENSG00000167515" "TRAPPC2L" "B2R4M9; hsa:51693; Q6ZTA7; Q9NZZ4; Q9UL33" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6534494641521229151" "False" "High" "IsMasterProtein" "Q9H8M2" "Bromodomain-containing protein 9 OS=Homo sapiens OX=9606 GN=BRD9 PE=1 SV=2" "0.009" "False" "2.092" "1" "1" "1" "1" "597" "67.0" "6.19" "0.00" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf12024" "65980" "ENSG00000028310" "BRD9" "A6NFY8; B4DMQ2; B4DR93; hsa:65980; Q2XUS1; Q6UWU9; Q8IUS4; Q9H5Q5; Q9H7R9; Q9H8M2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8431267486707138909" "False" "Medium" "IsMasterProtein" "Q8TEA7" "TBC domain-containing protein kinase-like protein OS=Homo sapiens OX=9606 GN=TBCK PE=1 SV=4" "0.010" "False" "2.090" "1" "1" "1" "1" "893" "100.6" "6.58" "2.84" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00566, Pf00581" "93627" "ENSG00000145348" "TBCK" "B9A6J1; hsa:93627; Q4W5B3; Q4W5E1; Q6NUP4; Q8N7M8; Q8TEA7; Q8WW57; Q96GV6; Q9P080" "" "" "0" "0" "1.136" "1.091" "1.098" "1.131" "1.116" "1.212" "1.185" "1.122" "1.107" "138.5" "157.4" "151.0" "152.0" "156.7" "154.6" "167.9" "164.1" "155.4" "153.2" "" "" "" "" "" "" "" "" "" "" "129.7" "130.2" "140.2" "117.5" "133.5" "147.7" "153.4" "145.7" "155.4" "147.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3114366665604462397" "False" "Medium" "IsMasterProtein" "Q9BZE2" "tRNA pseudouridine(38/39) synthase OS=Homo sapiens OX=9606 GN=PUS3 PE=1 SV=3" "0.010" "False" "2.089" "1" "1" "1" "1" "481" "55.6" "7.49" "3.16" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01416" "83480" "ENSG00000110060" "PUS3" "B2RAM0; hsa:83480; Q96D17; Q96J23; Q96NB4; Q9BZE2" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.980" "0.984" "1.076" "1.023" "1.009" "1.109" "1.067" "0.956" "0.994" "204.5" "200.5" "201.3" "220.0" "209.3" "206.3" "226.9" "218.2" "195.5" "203.2" "" "" "" "" "" "" "" "" "" "" "191.6" "165.9" "186.9" "170.0" "178.4" "197.1" "207.3" "193.7" "195.5" "195.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5269036548224773448" "False" "Medium" "IsMasterProtein" "Q6UXH1" "Protein disulfide isomerase CRELD2 OS=Homo sapiens OX=9606 GN=CRELD2 PE=1 SV=1" "0.010" "False" "2.087" "2" "1" "1" "1" "353" "38.2" "4.59" "2.90" "1" "" "non-structural extracellular;ER/Golgi" "other molecular function" "Pf07645" "79174" "ENSG00000184164" "CRELD2" "A5GZA2; A5GZA3; A5GZA4; A5GZA5; A5GZA6; hsa:79174; Q4W0V0; Q6UXH1; Q86UC0; Q9BU47" "" "" "0" "0" "1.112" "0.942" "0.934" "1.054" "1.030" "0.958" "0.996" "0.881" "0.961" "151.6" "168.5" "142.8" "141.6" "159.7" "156.2" "145.2" "151.0" "133.6" "145.6" "" "" "" "" "" "" "" "" "" "" "142.0" "139.5" "132.5" "109.5" "136.1" "149.2" "132.7" "134.1" "133.6" "140.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9014101916445181907" "False" "Medium" "IsMasterProtein" "Q6BDS2" "Bridge-like lipid transfer protein family member 3A OS=Homo sapiens OX=9606 GN=BLTP3A PE=1 SV=1" "0.010" "False" "2.082" "1" "1" "1" "1" "1440" "159.4" "6.14" "2.77" "1" "" "other cytoplasmic organelle" "other molecular function" "Pf12624" "54887" "ENSG00000065060" "BLTP3A" "hsa:54887; Q6BDS2; Q9NXE0" "" "" "0" "0" "0.963" "0.947" "0.897" "1.059" "0.888" "0.902" "0.874" "0.880" "0.832" "215.8" "207.7" "204.3" "193.6" "228.4" "191.6" "194.7" "188.6" "189.9" "179.5" "" "" "" "" "" "" "" "" "" "" "202.2" "171.9" "189.7" "149.6" "194.7" "183.1" "177.9" "167.5" "189.9" "172.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "514101839783017752" "False" "Medium" "IsMasterProtein" "Q9P021" "Cysteine-rich PDZ-binding protein OS=Homo sapiens OX=9606 GN=CRIPT PE=1 SV=1" "0.010" "False" "2.076" "11" "1" "1" "1" "101" "11.2" "9.47" "2.74" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10235" "9419" "ENSG00000119878" "CRIPT" "hsa:9419; Q9P021" "" "" "0" "0" "1.049" "1.120" "1.235" "1.001" "0.899" "0.998" "0.961" "0.965" "0.985" "122.3" "128.3" "136.9" "151.0" "122.4" "109.9" "122.0" "117.5" "117.9" "120.4" "" "" "" "" "" "" "" "" "" "" "114.5" "106.1" "127.1" "116.7" "104.3" "105.0" "111.5" "104.3" "117.9" "115.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5531669477434534246" "False" "Medium" "IsMasterProtein" "Q9NX01" "Thioredoxin-like protein 4B OS=Homo sapiens OX=9606 GN=TXNL4B PE=1 SV=1" "0.010" "False" "2.073" "5" "1" "1" "1" "149" "17.0" "6.00" "2.75" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf02966" "54957" "ENSG00000140830" "TXNL4B" "D3DWS6; hsa:54957; Q9NX01" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4022401648324513827" "False" "Medium" "IsMasterProtein" "Q9H6W3" "Ribosomal oxygenase 1 OS=Homo sapiens OX=9606 GN=RIOX1 PE=1 SV=2" "0.010" "False" "2.073" "2" "1" "1" "1" "641" "71.0" "6.46" "2.23" "1" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf08007, Pf21233" "79697" "ENSG00000170468" "RIOX1" "B4DT02; hsa:79697; Q9H6W3" "" "Protein hydroxylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3344145202623347770" "False" "Medium" "IsMasterProtein" "O60637" "Tetraspanin-3 OS=Homo sapiens OX=9606 GN=TSPAN3 PE=1 SV=1" "0.010" "False" "2.066" "3" "1" "1" "1" "253" "28.0" "5.81" "2.72" "1" "" "other membranes" "" "Pf00335" "10099" "ENSG00000140391" "TSPAN3" "A6NEH4; B3KQQ2; B4DP19; hsa:10099; O60637; Q9BW22; Q9NVX9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4235528814650407609" "False" "Medium" "IsMasterProtein" "Q96DT6" "Cysteine protease ATG4C OS=Homo sapiens OX=9606 GN=ATG4C PE=1 SV=1" "0.010" "False" "2.064" "2" "1" "1" "1" "458" "52.5" "5.97" "2.44" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "other cell component" "other molecular function" "Pf03416, Pf20166" "84938" "ENSG00000125703" "ATG4C" "A6NLR8; D3DQ58; hsa:84938; Q96DT6; Q96K04" "Clock-controlled autophagy in bone metabolism" "Macroautophagy" "2" "0" "1.100" "1.110" "1.229" "1.182" "1.061" "1.124" "1.100" "1.046" "1.014" "76.9" "84.6" "85.3" "94.5" "90.9" "81.5" "86.4" "84.6" "80.4" "78.0" "" "" "" "" "" "" "" "" "" "" "72.0" "70.0" "79.2" "73.1" "77.5" "77.9" "79.0" "75.1" "80.4" "75.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-180619704287479053" "False" "Medium" "IsMasterProtein" "P01137" "Transforming growth factor beta-1 proprotein OS=Homo sapiens OX=9606 GN=TGFB1 PE=1 SV=3" "0.010" "False" "2.064" "2" "1" "2" "1" "390" "44.3" "8.53" "4.08" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00019, Pf00688" "7040" "ENSG00000105329" "TGFB1" "A8K792; hsa:7040; P01137; Q9UCG4" "MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Cell cycle; Allograft rejection; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Cardiac progenitor differentiation; Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Cardiac hypertrophic response; Mammary gland development pathway - Embryonic development (Stage 1 of 4); Pluripotent stem cell differentiation pathway; Endoderm differentiation; Dopaminergic neurogenesis; IL-3 signaling pathway; Extracellular vesicle-mediated signaling in recipient cells; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Lung fibrosis; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Interactions between LOXL4 and oxidative stress pathway; MAPK signaling pathway; Canonical and non-canonical TGF-B signaling; Clear cell renal cell carcinoma pathways; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Type 2 papillary renal cell carcinoma; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Neovascularization processes; Nonalcoholic fatty liver disease; Platelet-mediated interactions with vascular and circulating cells; Control of immune tolerance by vasoactive intestinal peptide; Selective expression of chemokine receptors during T-cell polarization; Signal transduction through IL1R; Envelope proteins and their potential roles in EDMD physiopathology; Interactions between immune cells and microRNAs in tumor microenvironment; Hepatitis B infection; Endochondral ossification; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Overlap between signal transduction pathways contributing to LMNA laminopathies; 3q29 copy number variation syndrome; Angiotensin II receptor type 1 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; T cell modulation in pancreatic cancer; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Complement system in neuronal development and plasticity; Overview of proinflammatory and profibrotic mediators; CCL18 signaling pathway; Progeria-associated lipodystrophy; Th17 cell differentiation pathway; Urotensin-II-mediated signaling pathway; Ulcerative colitis signaling; Inflammatory bowel disease signaling; Clock-controlled autophagy in bone metabolism; Markers of kidney cell lineage; Comprehensive IL-17A signaling; Cell interactions of the pancreatic cancer microenvironment; Immune infiltration in pancreatic cancer; Cytokines and inflammatory response; 1p36 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; Affected pathways in Duchenne muscular dystrophy; IL-19 signaling pathway; ACE inhibitor pathway; TGF-beta receptor signaling; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "Cell surface interactions at the vascular wall; Transcriptional regulation of white adipocyte differentiation; UCH proteinases; ECM proteoglycans; Platelet degranulation ; Regulation of RUNX3 expression and activity; Interleukin-4 and Interleukin-13 signaling; Syndecan interactions; Downregulation of TGF-beta receptor signaling; Molecules associated with elastic fibres; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; RUNX3 regulates p14-ARF; Influenza Virus Induced Apoptosis; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); TGFBR2 MSI Frameshift Mutants in Cancer; TGFBR2 Kinase Domain Mutants in Cancer; TGFBR1 LBD Mutants in Cancer; RUNX3 regulates CDKN1A transcription" "95" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8510167409158157300" "False" "Medium" "IsMasterProtein" "Q8TB05" "UBA-like domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBALD1 PE=1 SV=1" "0.010" "False" "2.063" "5" "1" "1" "1" "177" "18.9" "6.64" "2.28" "1" "" "" "" "Pf14555" "124402" "ENSG00000153443" "UBALD1" "hsa:124402; Q71MF6; Q8TB05" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4790562829176069588" "False" "Medium" "IsMasterProtein" "Q9BV19" "Uncharacterized protein C1orf50 OS=Homo sapiens OX=9606 GN=C1orf50 PE=1 SV=2" "0.010" "False" "2.063" "4" "1" "2" "1" "199" "21.9" "5.88" "4.97" "1" "" "" "other molecular function" "Pf10504" "79078" "ENSG00000164008" "C1orf50" "Q9BV19" "" "" "0" "0" "0.883" "0.948" "1.092" "1.003" "1.058" "1.039" "1.076" "1.110" "0.937" "121.1" "106.9" "114.7" "132.2" "121.5" "128.1" "125.8" "130.2" "134.4" "113.5" "" "" "" "" "" "" "" "" "" "" "113.4" "88.4" "106.5" "102.2" "103.5" "122.4" "114.9" "115.6" "134.4" "109.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2106052778808331693" "False" "Medium" "IsMasterProtein" "P62910" "Large ribosomal subunit protein eL32 OS=Homo sapiens OX=9606 GN=RPL32 PE=1 SV=2" "0.010" "False" "2.062" "5" "1" "1" "1" "135" "15.9" "11.33" "2.67" "1" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01655" "6161" "ENSG00000144713" "RPL32" "B2R4Q3; hsa:6161; P02433; P62910" "Cytoplasmic ribosomal proteins" "Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.061" "0.960" "1.012" "1.147" "0.974" "1.264" "0.934" "0.935" "1.066" "81.8" "86.7" "78.5" "82.8" "93.8" "79.6" "103.3" "76.4" "76.4" "87.1" "" "" "" "" "" "" "" "" "" "" "76.6" "71.8" "72.9" "64.0" "79.9" "76.1" "94.4" "67.8" "76.4" "83.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3610986345004973856" "False" "Medium" "IsMasterProtein" "P82664" "Small ribosomal subunit protein uS10m OS=Homo sapiens OX=9606 GN=MRPS10 PE=1 SV=2" "0.010" "False" "2.059" "3" "1" "1" "1" "201" "23.0" "8.00" "3.00" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf00338" "55173" "ENSG00000048544" "MRPS10" "B2RE89; hsa:55173; P82664; Q9H3E5; Q9NVR3" "" "Mitochondrial protein degradation; Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "0.953" "1.078" "0.877" "0.959" "1.012" "0.913" "0.929" "0.976" "0.979" "319.0" "304.1" "344.0" "279.9" "306.0" "323.0" "291.2" "296.5" "311.2" "312.2" "" "" "" "" "" "" "" "" "" "" "298.9" "251.7" "319.3" "216.4" "260.8" "308.6" "266.1" "263.3" "311.2" "300.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4435404438671900713" "False" "Medium" "IsMasterProtein" "Q96N11" "Integrator complex subunit 15 OS=Homo sapiens OX=9606 GN=INTS15 PE=1 SV=1" "0.010" "False" "2.058" "2" "1" "1" "1" "449" "50.0" "7.69" "3.53" "1" "" "nucleus" "" "Pf14964" "79034" "ENSG00000146576" "INTS15" "Q96N11; Q9BQ43" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4738294880547824619" "False" "Medium" "IsMasterProtein" "Q9BQ15" "SOSS complex subunit B1 OS=Homo sapiens OX=9606 GN=NABP2 PE=1 SV=1" "0.010" "False" "2.057" "3" "1" "1" "1" "211" "22.3" "9.06" "3.12" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf21473" "79035" "ENSG00000139579" "NABP2" "A6NDF8; hsa:79035; Q6XYC8; Q9BQ15" "Mesodermal commitment pathway" "RNA polymerase II transcribes snRNA genes" "2" "0" "0.954" "0.922" "0.872" "1.065" "1.076" "1.033" "1.118" "1.023" "1.044" "236.1" "225.1" "217.7" "206.0" "251.5" "253.9" "244.0" "264.0" "241.6" "246.5" "" "" "" "" "" "" "" "" "" "" "221.2" "186.3" "202.1" "159.2" "214.4" "242.6" "222.9" "234.4" "241.6" "237.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7073332157955076013" "False" "Medium" "IsMasterProtein" "P50914" "Large ribosomal subunit protein eL14 OS=Homo sapiens OX=9606 GN=RPL14 PE=1 SV=4" "0.011" "False" "2.053" "6" "1" "1" "1" "215" "23.4" "10.93" "3.13" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01929" "9045" "ENSG00000188846" "RPL14" "hsa:9045; P50914; Q45RF0; Q53G20; Q8TBD5; Q8WUT0; Q92579; Q96GR0; Q9BSB8; Q9BW65; Q9BYF6" "Cytoplasmic ribosomal proteins" "Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.205" "1.122" "1.368" "1.324" "1.121" "1.108" "1.142" "1.170" "1.053" "39.5" "47.5" "44.3" "54.0" "52.3" "44.2" "43.7" "45.1" "46.2" "41.6" "" "" "" "" "" "" "" "" "" "" "37.0" "39.3" "41.1" "41.7" "44.5" "42.3" "40.0" "40.0" "46.2" "40.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7079848071820702284" "False" "Medium" "IsMasterProtein" "Q9BPY3" "Protein FAM118B OS=Homo sapiens OX=9606 GN=FAM118B PE=1 SV=1" "0.011" "False" "2.048" "3" "1" "1" "1" "351" "39.5" "5.99" "3.19" "1" "" "nucleus" "other molecular function" "Pf13289" "79607" "ENSG00000197798" "FAM118B" "hsa:79607; Q9BPY3; Q9H7B0" "" "" "0" "0" "1.046" "1.034" "1.197" "1.187" "0.983" "1.126" "1.059" "0.966" "1.124" "97.1" "101.6" "100.4" "116.2" "115.2" "95.4" "109.3" "102.8" "93.8" "109.2" "" "" "" "" "" "" "" "" "" "" "91.0" "84.1" "93.2" "89.8" "98.2" "91.2" "99.9" "91.3" "93.8" "105.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6233327250994460082" "False" "Medium" "IsMasterProtein" "Q96HU1" "Small G protein signaling modulator 3 OS=Homo sapiens OX=9606 GN=SGSM3 PE=1 SV=1" "0.011" "False" "2.041" "1" "1" "1" "1" "749" "85.3" "6.00" "3.18" "1" "cell cycle OR cell proliferation;transport;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00566, Pf02759" "27352" "ENSG00000100359" "SGSM3" "B0QY79; hsa:27352; Q7Z709; Q96HU1; Q9NT69" "Ectoderm differentiation; Ectoderm differentiation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4245870540652335533" "False" "Medium" "IsMasterProtein" "Q8N8N7" "Prostaglandin reductase 2 OS=Homo sapiens OX=9606 GN=PTGR2 PE=1 SV=1" "0.011" "False" "2.037" "2" "1" "1" "1" "351" "38.5" "5.41" "3.00" "1" "other metabolic processes" "other cell component" "other molecular function" "Pf00107, Pf16884" "145482" "ENSG00000140043" "PTGR2" "hsa:145482; Q3L8A4; Q6MZH8; Q8N8N7" "Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-6-fatty acids in senescence" "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1367538517643276436" "False" "Medium" "IsMasterProtein" "Q13724" "Mannosyl-oligosaccharide glucosidase OS=Homo sapiens OX=9606 GN=MOGS PE=1 SV=5" "0.011" "False" "2.037" "1" "1" "1" "1" "837" "91.9" "8.90" "2.26" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf03200, Pf16923" "7841" "ENSG00000115275" "MOGS" "A8K938; F5H6D0; hsa:7841; Q13724; Q17RN9; Q8TCT5" "N-glycan biosynthesis" "Maturation of spike protein; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Maturation of spike protein; Defective MOGS causes CDG-2b" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1113653796691851863" "False" "Medium" "IsMasterProtein" "Q86X83" "COMM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=COMMD2 PE=1 SV=2" "0.011" "False" "2.023" "4" "1" "2" "1" "199" "22.7" "6.73" "5.42" "1" "" "other cell component" "" "Pf07258" "51122" "ENSG00000114744" "COMMD2" "hsa:51122; Q561V4; Q86X83; Q9H3L5; Q9Y5V1" "" "Neddylation" "1" "0" "0.891" "0.964" "0.918" "0.903" "0.886" "0.865" "0.852" "0.882" "0.915" "264.4" "235.6" "254.9" "242.7" "238.7" "234.3" "228.7" "225.4" "233.4" "242.0" "" "" "" "" "" "" "" "" "" "" "247.8" "194.9" "236.7" "187.6" "203.5" "223.8" "209.0" "200.1" "233.4" "233.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4477841957846680674" "False" "Medium" "IsMasterProtein" "Q8IZL2" "Mastermind-like protein 2 OS=Homo sapiens OX=9606 GN=MAML2 PE=1 SV=2" "0.012" "False" "2.018" "1" "1" "2" "1" "1156" "125.1" "9.42" "4.02" "1" "signal transduction;other biological processes" "nucleus" "other molecular function" "Pf09596, Pf20804" "84441" "ENSG00000184384" "MAML2" "A7MD26; hsa:84441; Q6AI23; Q6Y3A3; Q8IUL3; Q8IZL2; Q96JK6" "Canonical and non-canonical Notch signaling; Notch signaling pathway" "Pre-NOTCH Transcription and Translation; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH2 intracellular domain regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "13" "0" "1.132" "1.003" "1.174" "1.015" "1.141" "1.048" "1.034" "0.758" "1.030" "27.0" "30.6" "27.1" "31.7" "27.4" "30.8" "28.3" "27.9" "20.5" "27.8" "" "" "" "" "" "" "" "" "" "" "25.3" "25.3" "25.1" "24.5" "23.3" "29.4" "25.9" "24.8" "20.5" "26.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4276327742936350895" "False" "Medium" "IsMasterProtein" "Q9H582" "Zinc finger protein 644 OS=Homo sapiens OX=9606 GN=ZNF644 PE=1 SV=2" "0.012" "False" "2.017" "1" "1" "1" "1" "1327" "149.5" "8.16" "2.81" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "84146" "ENSG00000122482" "ZNF644" "A2RU71; hsa:84146; Q2TAM0; Q5TCC0; Q6BEP7; Q6P446; Q6PI06; Q7LG67; Q9H582; Q9ULJ9" "" "" "0" "0" "1.075" "1.072" "1.039" "1.110" "1.005" "1.148" "1.155" "1.111" "1.037" "132.0" "141.9" "141.5" "137.1" "146.6" "132.7" "151.5" "152.4" "146.6" "136.9" "" "" "" "" "" "" "" "" "" "" "123.7" "117.4" "131.4" "106.0" "124.9" "126.7" "138.4" "135.3" "146.6" "131.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9218413933663046197" "False" "Medium" "IsMasterProtein" "Q8WZ19" "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 OS=Homo sapiens OX=9606 GN=KCTD13 PE=1 SV=1" "0.012" "False" "2.011" "2" "1" "1" "1" "329" "36.3" "7.23" "2.94" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02214" "253980" "ENSG00000174943" "KCTD13" "A8K0R5; hsa:253980; Q8WZ19; Q96P93; Q96SA1" "16p11.2 proximal deletion syndrome" "RND2 GTPase cycle; RND3 GTPase cycle" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "433749903708797592" "False" "Medium" "IsMasterProtein" "Q8NB46" "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C OS=Homo sapiens OX=9606 GN=ANKRD52 PE=1 SV=3" "0.012" "False" "2.010" "1" "1" "1" "1" "1076" "115.0" "6.48" "1.93" "1" "" "" "" "Pf00023, Pf12796" "283373" "ENSG00000139645" "ANKRD52" "A6NE79; B1Q2K2; hsa:283373; Q8NB46" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8923754017779297003" "False" "Medium" "IsMasterProtein" "Q9H6A0" "DENN domain-containing protein 2D OS=Homo sapiens OX=9606 GN=DENND2D PE=1 SV=2" "0.012" "False" "2.009" "2" "1" "1" "1" "471" "53.6" "7.64" "2.30" "1" "" "cytosol;nucleus" "enzyme regulator activity" "Pf02141, Pf03455, Pf03456" "79961" "ENSG00000162777" "DENND2D" "hsa:79961; Q5T5V6; Q9BSU0; Q9H6A0" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.151" "1.316" "1.339" "1.226" "1.431" "1.528" "1.027" "1.390" "1.253" "20.2" "23.2" "26.6" "27.0" "24.8" "28.9" "30.8" "20.7" "28.1" "25.3" "" "" "" "" "" "" "" "" "" "" "18.9" "19.2" "24.7" "20.9" "21.1" "27.6" "28.2" "18.4" "28.1" "24.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1179356982440791831" "False" "Medium" "IsMasterProtein" "Q6ZNW5" "GDP-D-glucose phosphorylase 1 OS=Homo sapiens OX=9606 GN=GDPGP1 PE=1 SV=2" "0.012" "False" "2.009" "2" "1" "1" "1" "385" "42.3" "6.47" "2.88" "1" "other metabolic processes" "other cell component" "enzyme regulator activity;other molecular function" "" "390637" "ENSG00000183208" "GDPGP1" "hsa:390637; Q6ZNW5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2982009215915538431" "False" "Medium" "IsMasterProtein" "Q8TBA6" "Golgin subfamily A member 5 OS=Homo sapiens OX=9606 GN=GOLGA5 PE=1 SV=3" "0.013" "False" "2.001" "2" "1" "1" "1" "731" "83.0" "5.83" "2.37" "1" "cell organization and biogenesis;transport" "other membranes;ER/Golgi" "other molecular function" "Pf09787" "9950" "ENSG00000066455" "GOLGA5" "C9JRU1; hsa:9950; O95287; Q03962; Q2TS49; Q8TBA6; Q9UQQ7" "" "Intra-Golgi traffic" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8871370198028658557" "False" "Medium" "IsMasterProtein" "P62995" "Transformer-2 protein homolog beta OS=Homo sapiens OX=9606 GN=TRA2B PE=1 SV=1" "0.013" "False" "2.000" "2" "1" "1" "1" "288" "33.6" "11.25" "3.00" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6434" "ENSG00000136527" "TRA2B" "B4DVK2; D3DNU3; hsa:6434; O15449; P62995; Q15815; Q64283" "mRNA processing" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "5" "0" "1.023" "1.007" "0.912" "0.866" "0.878" "0.902" "0.829" "0.970" "0.940" "295.8" "302.7" "297.9" "269.7" "256.1" "259.8" "266.7" "245.1" "286.9" "278.0" "" "" "" "" "" "" "" "" "" "" "277.1" "250.5" "276.6" "208.5" "218.3" "248.2" "243.7" "217.6" "286.9" "267.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3672343249527762985" "False" "Medium" "IsMasterProtein" "Q9H8M7" "Ubiquitin carboxyl-terminal hydrolase MINDY-3 OS=Homo sapiens OX=9606 GN=MINDY3 PE=1 SV=1" "0.013" "False" "1.999" "2" "1" "1" "1" "445" "49.7" "4.77" "2.78" "1" "protein metabolism;other biological processes" "other membranes;nucleus" "other molecular function" "Pf13898" "80013" "ENSG00000148481" "MINDY3" "Q5SZ68; Q5SZ69; Q5SZ70; Q6IA40; Q6P7P0; Q7Z2S1; Q8WUF1; Q9H3I4; Q9H8M7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3474294696230131597" "False" "Medium" "IsMasterProtein" "Q86WN1" "F-BAR and double SH3 domains protein 1 OS=Homo sapiens OX=9606 GN=FCHSD1 PE=1 SV=1" "0.013" "False" "1.995" "1" "1" "1" "1" "690" "76.9" "5.34" "2.61" "1" "cell-cell signaling;cell organization and biogenesis" "cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00611, Pf14604" "89848" "ENSG00000197948" "FCHSD1" "hsa:89848; Q6UX75; Q86WN1; Q86Y77; Q9NXX8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3666835465541347575" "False" "Medium" "IsMasterProtein" "Q14684" "Ribosomal RNA processing protein 1 homolog B OS=Homo sapiens OX=9606 GN=RRP1B PE=1 SV=3" "0.013" "False" "1.992" "1" "1" "1" "1" "758" "84.4" "9.76" "3.81" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05997" "23076" "ENSG00000160208" "RRP1B" "hsa:23076; Q14684; Q8TBZ4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3413891887359958114" "False" "Medium" "IsMasterProtein" "Q9BQC6" "Large ribosomal subunit protein mL63 OS=Homo sapiens OX=9606 GN=MRPL57 PE=1 SV=1" "0.013" "False" "1.988" "7" "1" "1" "1" "102" "12.3" "11.44" "3.33" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf14978" "78988" "ENSG00000173141" "MRPL57" "A2A332; hsa:78988; Q9BQC6" "" "Mitochondrial translation elongation; Mitochondrial translation initiation; Mitochondrial translation termination" "3" "0" "0.926" "0.981" "0.867" "0.992" "0.955" "0.895" "0.891" "0.962" "0.871" "375.5" "347.7" "368.3" "325.7" "372.5" "358.5" "336.1" "334.6" "361.1" "326.9" "" "" "" "" "" "" "" "" "" "" "351.8" "287.7" "341.9" "251.8" "317.5" "342.5" "307.1" "297.1" "361.1" "314.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3502078554473107066" "False" "Medium" "IsMasterProtein" "O75264" "Small integral membrane protein 24 OS=Homo sapiens OX=9606 GN=SMIM24 PE=1 SV=2" "0.013" "False" "1.988" "5" "1" "1" "1" "130" "15.0" "5.29" "2.26" "1" "" "other membranes" "" "Pf15807" "284422" "ENSG00000095932" "SMIM24" "B9EJF4; hsa:284422; O75264; Q9P059" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2153846373237469849" "False" "Medium" "IsMasterProtein" "Q5VV42" "Threonylcarbamoyladenosine tRNA methylthiotransferase OS=Homo sapiens OX=9606 GN=CDKAL1 PE=1 SV=1" "0.013" "False" "1.987" "1" "1" "1" "1" "579" "65.1" "7.46" "0.00" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00919, Pf01938, Pf04055" "54901" "ENSG00000145996" "CDKAL1" "A8K6S0; hsa:54901; Q5VV42; Q6P385; Q6ZR27; Q9NXB3" "Vitamin D receptor pathway" "tRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5481999145785507912" "False" "Medium" "IsMasterProtein" "Q8TAV3" "Cytochrome P450 2W1 OS=Homo sapiens OX=9606 GN=CYP2W1 PE=1 SV=2" "0.013" "False" "1.984" "1" "1" "1" "1" "490" "53.8" "8.70" "2.96" "1" "other metabolic processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00067" "54905" "ENSG00000073067" "CYP2W1" "hsa:54905; Q8TAV3" "Oxidation by cytochrome P450; Metapathway biotransformation Phase I and II" "Xenobiotics; Miscellaneous substrates" "4" "0" "0.960" "1.078" "1.047" "0.923" "1.057" "0.867" "0.856" "0.883" "0.999" "162.8" "156.3" "175.6" "170.5" "150.4" "172.2" "141.2" "139.4" "143.7" "162.7" "" "" "" "" "" "" "" "" "" "" "152.6" "129.4" "163.0" "131.8" "128.2" "164.5" "129.0" "123.8" "143.7" "156.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2998766617902893478" "False" "Medium" "IsMasterProtein" "Q03181" "Peroxisome proliferator-activated receptor delta OS=Homo sapiens OX=9606 GN=PPARD PE=1 SV=1" "0.013" "False" "1.982" "2" "1" "1" "1" "441" "49.9" "7.59" "3.17" "1" "cell adhesion;cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105" "5467" "ENSG00000112033" "PPARD" "A8K6J6; B4E3V3; B6ZGS1; B7Z3W1; E9PE18; hsa:5467; Q03181; Q5D1P0; Q7Z5K0; Q9BUD4" "Energy metabolism; Nuclear receptors; Adipogenesis; Ectoderm differentiation; Vitamin D receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Nuclear receptors in lipid metabolism and toxicity; Ectoderm differentiation; Wnt/beta-catenin signaling pathway in leukemia; PPAR signaling pathway; Wnt signaling pathway and pluripotency; SCFA and skeletal muscle substrate metabolism; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Acute myeloid leukemia" "Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Nuclear Receptor transcription pathway; Carnitine metabolism" "20" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7917199320651257178" "False" "Medium" "IsMasterProtein" "P53801" "Pituitary tumor-transforming gene 1 protein-interacting protein OS=Homo sapiens OX=9606 GN=PTTG1IP PE=1 SV=1" "0.013" "False" "1.981" "4" "1" "1" "1" "180" "20.3" "8.79" "3.20" "1" "transport;other biological processes" "nucleus;other cell component" "other molecular function" "" "754" "ENSG00000183255" "PTTG1IP" "B2RDP7; D3DSL9; hsa:754; P53801; Q9NS09" "" "" "0" "0" "0.915" "0.959" "0.949" "1.038" "1.035" "0.822" "0.959" "0.983" "0.949" "237.6" "217.3" "227.9" "225.4" "246.5" "245.8" "195.2" "227.8" "233.4" "225.5" "" "" "" "" "" "" "" "" "" "" "222.6" "179.8" "211.6" "174.2" "210.1" "234.8" "178.4" "202.3" "233.4" "217.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2998075860950209884" "False" "Medium" "IsMasterProtein" "Q9NXL9" "DNA helicase MCM9 OS=Homo sapiens OX=9606 GN=MCM9 PE=1 SV=4" "0.013" "False" "1.980" "1" "1" "2" "1" "1143" "127.2" "7.74" "4.51" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf17207, Pf17855" "254394" "ENSG00000111877" "MCM9" "B4DR30; B9DI77; hsa:254394; Q2KHJ0; Q8N5S5; Q9HCV5; Q9NXL9" "Ciliary landscape; Primary ovarian insufficiency" "" "2" "0" "0.916" "0.921" "0.938" "0.924" "0.903" "0.897" "0.944" "0.892" "0.845" "242.7" "222.4" "223.4" "227.7" "224.4" "219.2" "217.8" "229.2" "216.6" "205.0" "" "" "" "" "" "" "" "" "" "" "227.4" "184.0" "207.4" "176.0" "191.3" "209.5" "199.0" "203.5" "216.6" "197.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2667466145755123608" "False" "Medium" "IsMasterProtein" "O75380" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS6 PE=1 SV=1" "0.013" "False" "1.979" "6" "1" "1" "1" "124" "13.7" "8.28" "2.84" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf10276" "4726" "ENSG00000145494" "NDUFS6" "hsa:4726; O75380" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8131679438842451917" "False" "Medium" "IsMasterProtein" "P10242" "Transcriptional activator Myb OS=Homo sapiens OX=9606 GN=MYB PE=1 SV=2" "0.013" "False" "1.979" "1" "1" "1" "1" "640" "72.3" "6.83" "3.18" "1" "cell cycle OR cell proliferation;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00249, Pf07988, Pf09316" "4602" "ENSG00000118513" "MYB" "E9PI07; E9PLZ5; E9PNA4; E9PNL6; E9PRS2; hsa:4602; P10242; P78391; P78392; P78525; P78526; Q14023; Q14024; Q708E4; Q708E7; Q9UE83" "Neural crest differentiation; Hematopoietic stem cell differentiation; EV release from cardiac cells and their functional effects; Pathways affected in adenoid cystic carcinoma; PI3K-Akt signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Estrogen-dependent gene expression; Factors involved in megakaryocyte development and platelet production; Transcriptional regulation of granulopoiesis; Specification of the neural plate border" "11" "0" "0.952" "0.987" "0.887" "0.883" "0.912" "0.863" "0.775" "0.754" "0.885" "278.7" "265.4" "275.0" "247.3" "246.0" "254.2" "240.5" "215.9" "210.2" "246.7" "" "" "" "" "" "" "" "" "" "" "261.2" "219.6" "255.3" "191.2" "209.7" "242.8" "219.7" "191.7" "210.2" "237.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2873927276967630041" "False" "Medium" "IsMasterProtein" "Q2TAZ0" "Autophagy-related protein 2 homolog A OS=Homo sapiens OX=9606 GN=ATG2A PE=1 SV=3" "0.013" "False" "1.978" "1" "1" "1" "1" "1938" "212.7" "5.88" "0.00" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf09333, Pf12624" "23130" "ENSG00000110046" "ATG2A" "hsa:23130; O43154; Q14DM2; Q2TAZ0; Q6ZTV2; Q7Z6K8; Q8IVY5; Q8TAI8; Q96HH7" "Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Alzheimer's disease; ADHD and autism (ASD) linked metabolic pathways and SNP" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "587629030482776779" "False" "Medium" "IsMasterProtein" "Q5VZM2" "Ras-related GTP-binding protein B OS=Homo sapiens OX=9606 GN=RRAGB PE=1 SV=1" "0.014" "False" "1.978" "2" "1" "1" "1" "374" "43.2" "6.21" "1.85" "1" "stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04670" "10325" "ENSG00000083750" "RRAGB" "A8K042; hsa:10325; Q15348; Q5VZM2; Q8N3T0" "Target of rapamycin signaling; 2q37 copy number variation syndrome" "TP53 Regulates Metabolic Genes; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "9" "0" "1.049" "1.047" "1.129" "1.039" "1.049" "1.061" "1.002" "1.006" "1.069" "215.0" "225.6" "225.1" "242.7" "223.5" "225.6" "228.2" "215.4" "216.3" "229.9" "" "" "" "" "" "" "" "" "" "" "201.5" "186.7" "209.0" "187.7" "190.5" "215.6" "208.5" "191.3" "216.3" "221.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2504769513394967935" "False" "Medium" "IsMasterProtein" "Q2QD12" "Ribulose-phosphate 3-epimerase-like protein 1 OS=Homo sapiens OX=9606 GN=RPEL1 PE=1 SV=1" "0.014" "False" "1.974" "3" "1" "2" "1" "228" "25.0" "5.41" "5.21" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf00834" "729020" "ENSG00000235376" "RPEL1" "hsa:729020; Q2QD12" "" "Pentose phosphate pathway" "1" "0" "1.166" "1.022" "1.170" "1.025" "1.023" "1.071" "1.105" "1.065" "1.109" "131.1" "152.8" "134.0" "153.4" "134.3" "134.1" "140.4" "144.8" "139.6" "145.3" "" "" "" "" "" "" "" "" "" "" "122.8" "126.4" "124.4" "118.6" "114.5" "128.1" "128.3" "128.6" "139.6" "139.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5992266541679764687" "False" "Medium" "IsMasterProtein" "P30414" "NK-tumor recognition protein OS=Homo sapiens OX=9606 GN=NKTR PE=1 SV=2" "0.014" "False" "1.974" "0" "1" "1" "1" "1462" "165.6" "9.99" "2.88" "1" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00160" "4820" "ENSG00000114857" "NKTR" "hsa:4820; P30414" "" "" "0" "0" "1.022" "1.016" "0.958" "1.114" "1.016" "0.899" "0.986" "1.034" "1.052" "230.0" "234.9" "233.6" "220.2" "256.2" "233.6" "206.8" "226.8" "237.9" "242.0" "" "" "" "" "" "" "" "" "" "" "215.5" "194.4" "216.8" "170.3" "218.4" "223.2" "189.0" "201.3" "237.9" "233.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3945709348519994010" "False" "Medium" "IsMasterProtein" "Q96I23" "Protein preY, mitochondrial OS=Homo sapiens OX=9606 GN=PYURF PE=1 SV=1" "0.014" "False" "1.968" "7" "1" "2" "1" "114" "12.6" "9.33" "5.07" "1" "other biological processes" "other membranes;mitochondrion;ER/Golgi" "" "Pf03966" "100996939" "ENSG00000145337" "PYURF" "B2R571; hsa:100996939; Q96I23" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5807037256963766302" "False" "Medium" "IsMasterProtein" "Q9H0F7" "ADP-ribosylation factor-like protein 6 OS=Homo sapiens OX=9606 GN=ARL6 PE=1 SV=1" "0.014" "False" "1.967" "4" "1" "1" "1" "186" "21.1" "8.54" "2.83" "1" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf00025" "84100" "ENSG00000113966" "ARL6" "A8KA93; D3DN31; hsa:84100; Q9H0F7" "Ciliopathies; Bardet-Biedl syndrome" "BBSome-mediated cargo-targeting to cilium" "3" "0" "1.050" "1.116" "1.110" "1.094" "1.143" "1.055" "0.991" "1.060" "1.111" "194.3" "203.9" "216.8" "215.6" "212.6" "222.1" "205.0" "192.5" "205.9" "215.8" "" "" "" "" "" "" "" "" "" "" "182.0" "168.7" "201.2" "166.6" "181.2" "212.2" "187.3" "170.9" "205.9" "207.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5800402154155294758" "False" "Medium" "IsMasterProtein" "Q8N300" "Small vasohibin-binding protein OS=Homo sapiens OX=9606 GN=SVBP PE=1 SV=1" "0.014" "False" "1.965" "11" "1" "1" "1" "66" "7.8" "9.16" "2.65" "1" "cell organization and biogenesis;protein metabolism;transport;developmental processes;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity" "Pf15674" "374969" "ENSG00000177868" "SVBP" "A8K5P1; D3DPW7; hsa:374969; Q8N300" "" "Carboxyterminal post-translational modifications of tubulin" "1" "0" "1.105" "1.034" "1.068" "1.093" "1.027" "0.943" "1.067" "0.970" "1.097" "326.0" "360.2" "337.1" "348.0" "356.2" "334.8" "307.3" "347.8" "316.3" "357.5" "" "" "" "" "" "" "" "" "" "" "305.4" "298.1" "313.0" "269.0" "303.6" "319.9" "280.8" "308.8" "316.3" "344.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2990327377986760395" "False" "Medium" "IsMasterProtein" "Q8N9Q2" "Protein SREK1IP1 OS=Homo sapiens OX=9606 GN=SREK1IP1 PE=1 SV=1" "0.014" "False" "1.965" "5" "1" "1" "1" "155" "18.2" "9.85" "3.55" "1" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf13917" "285672" "ENSG00000153006" "SREK1IP1" "hsa:285672; Q32NC8; Q8N9Q2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1247286827746960266" "False" "Medium" "IsMasterProtein" "Q16649" "Nuclear factor interleukin-3-regulated protein OS=Homo sapiens OX=9606 GN=NFIL3 PE=1 SV=2" "0.015" "False" "1.960" "2" "1" "1" "1" "462" "51.4" "7.18" "2.93" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06529, Pf07716" "4783" "ENSG00000165030" "NFIL3" "B2R9Y8; hsa:4783; Q14211; Q16649; Q6FGQ8; Q96HS0" "Development and heterogeneity of the ILC family; IL-4 signaling pathway; Th17 cell differentiation pathway" "Circadian Clock" "4" "0" "1.015" "1.097" "1.101" "1.069" "1.171" "0.971" "0.924" "0.995" "1.101" "245.3" "248.9" "269.1" "270.0" "262.2" "287.2" "238.2" "226.6" "244.1" "270.0" "" "" "" "" "" "" "" "" "" "" "229.8" "205.9" "249.8" "208.7" "223.5" "274.4" "217.6" "201.2" "244.1" "259.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1017174203569406372" "False" "Medium" "IsMasterProtein" "Q86UW6" "NEDD4-binding protein 2 OS=Homo sapiens OX=9606 GN=N4BP2 PE=1 SV=2" "0.015" "False" "1.957" "1" "1" "1" "1" "1770" "198.7" "5.21" "1.82" "1" "DNA metabolism" "cytosol" "kinase activity;other molecular function" "Pf01713, Pf08590, Pf13671" "55728" "ENSG00000078177" "N4BP2" "A0AVR3; hsa:55728; Q86UW6; Q9NVK2; Q9P2D4" "" "" "0" "0" "0.909" "0.891" "0.838" "0.744" "0.696" "0.700" "0.658" "0.491" "0.818" "56.0" "50.9" "49.9" "46.9" "41.6" "38.9" "39.2" "36.8" "27.5" "45.8" "" "" "" "" "" "" "" "" "" "" "52.4" "42.1" "46.3" "36.2" "35.5" "37.2" "35.8" "32.7" "27.5" "44.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8386790215885090291" "False" "Medium" "IsMasterProtein" "Q8N3X1" "Formin-binding protein 4 OS=Homo sapiens OX=9606 GN=FNBP4 PE=1 SV=3" "0.015" "False" "1.956" "1" "1" "1" "1" "1017" "110.2" "4.74" "3.69" "1" "" "nucleus" "" "Pf00397" "23360" "ENSG00000109920; ENSG00000285182" "FNBP4" "hsa:23360; Q8N3X1; Q9H985; Q9NT81; Q9Y2L7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "673060285531934523" "False" "Medium" "IsMasterProtein" "Q8IWF6" "Protein DENND6A OS=Homo sapiens OX=9606 GN=DENND6A PE=1 SV=1" "0.015" "False" "1.955" "2" "1" "1" "1" "608" "69.5" "8.27" "3.12" "1" "other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf09794" "201627" "ENSG00000174839" "DENND6A" "hsa:201627; Q7Z5T4; Q8IWF6; Q8N235; Q8TEG8" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6440494837518419053" "False" "Medium" "IsMasterProtein" "Q9Y3B3" "Transmembrane emp24 domain-containing protein 7 OS=Homo sapiens OX=9606 GN=TMED7 PE=1 SV=2" "0.014" "False" "1.954" "3" "1" "1" "1" "224" "25.2" "6.89" "2.42" "1" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cell component" "" "Pf01105" "100302736; 51014" "ENSG00000134970" "TMED7" "hsa:100302736; hsa:51014; Q8NBU8; Q8WUU6; Q96K51; Q9Y3B3" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1947513766824077482" "False" "Medium" "IsMasterProtein" "Q9HCU9" "Breast cancer metastasis-suppressor 1 OS=Homo sapiens OX=9606 GN=BRMS1 PE=1 SV=1" "0.014" "False" "1.953" "3" "1" "2" "1" "246" "28.4" "4.74" "4.58" "1" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf08598" "25855" "ENSG00000174744" "BRMS1" "hsa:25855; Q6IAI2; Q9HCU9" "" "Potential therapeutics for SARS; HDACs deacetylate histones" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2783720911668015522" "False" "Medium" "IsMasterProtein" "Q9NWT6" "Hypoxia-inducible factor 1-alpha inhibitor OS=Homo sapiens OX=9606 GN=HIF1AN PE=1 SV=2" "0.014" "False" "1.953" "2" "1" "1" "1" "349" "40.3" "5.57" "3.25" "1" "other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13621" "55662" "ENSG00000166135" "HIF1AN" "D3DR69; hsa:55662; Q5W147; Q969Q7; Q9NPV5; Q9NWT6" "MicroRNA for targeting cancer growth and vascularization in glioblastoma; Photodynamic therapy-induced HIF-1 survival signaling" "Cellular response to hypoxia" "3" "0" "0.944" "1.022" "0.890" "0.976" "0.949" "0.904" "0.939" "0.887" "0.961" "246.0" "232.1" "251.4" "218.9" "240.1" "233.3" "222.5" "230.9" "218.3" "236.4" "" "" "" "" "" "" "" "" "" "" "230.5" "192.0" "233.4" "169.2" "204.6" "222.9" "203.3" "205.0" "218.3" "227.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3933155493213774730" "False" "Medium" "IsMasterProtein" "Cont_Q3SZV7" "Hemopexin OS=Bos taurus OX=9913 GN=HPX PE=2 SV=1" "0.015" "True" "1.952" "2" "1" "1" "1" "459" "52.2" "7.80" "2.57" "1" "other metabolic processes;transport;other biological processes" "non-structural extracellular" "transporter activity;other molecular function" "Pf00045" "534509" "ENSBIXG00000017851" "HPX" "A0A4W2EKG5; bta:534509; Q3SZV7" "" "" "0" "0" "1.022" "1.034" "0.934" "1.197" "1.330" "1.064" "1.141" "1.295" "1.241" "148.9" "152.2" "154.0" "139.1" "178.3" "198.1" "158.5" "169.9" "192.9" "184.8" "" "" "" "" "" "" "" "" "" "" "139.5" "126.0" "143.0" "107.5" "152.0" "189.3" "144.9" "150.8" "192.9" "177.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1730131359197889533" "False" "Medium" "IsMasterProtein" "Q8IVU3" "Probable E3 ubiquitin-protein ligase HERC6 OS=Homo sapiens OX=9606 GN=HERC6 PE=1 SV=2" "0.015" "False" "1.950" "1" "1" "1" "1" "1022" "115.1" "7.96" "2.18" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00415, Pf00632, Pf13540" "55008" "ENSG00000138642" "HERC6" "B4DIY5; hsa:55008; Q5GC90; Q5GRH3; Q5HYM6; Q5JPB6; Q6PIF4; Q8IVU3; Q8NAN3; Q9NWS4" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.980" "1.007" "0.947" "0.996" "0.859" "1.048" "1.119" "1.060" "0.914" "126.0" "123.5" "126.8" "119.3" "125.5" "108.3" "132.0" "140.9" "133.6" "115.2" "" "" "" "" "" "" "" "" "" "" "118.0" "102.2" "117.7" "92.2" "106.9" "103.4" "120.6" "125.1" "133.6" "110.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2558457419742153856" "False" "Medium" "IsMasterProtein" "P53567" "CCAAT/enhancer-binding protein gamma OS=Homo sapiens OX=9606 GN=CEBPG PE=1 SV=1" "0.015" "False" "1.949" "5" "1" "1" "1" "150" "16.4" "9.77" "2.63" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07716" "1054" "ENSG00000153879" "CEBPG" "B2R946; hsa:1054; P53567; Q5U052" "Differentiation of white and brown adipocyte; Transcriptional cascade regulating adipogenesis" "Response of EIF2AK1 (HRI) to heme deficiency; ATF4 activates genes in response to endoplasmic reticulum stress; Response of EIF2AK4 (GCN2) to amino acid deficiency" "5" "0" "1.028" "0.991" "1.108" "0.980" "1.024" "0.970" "0.965" "1.149" "1.030" "114.8" "118.0" "113.8" "127.1" "112.5" "117.5" "111.4" "110.8" "131.9" "118.3" "" "" "" "" "" "" "" "" "" "" "107.6" "97.7" "105.6" "98.3" "95.9" "112.3" "101.8" "98.4" "131.9" "113.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2534211096191502147" "False" "Medium" "IsMasterProtein" "O00560" "Syntenin-1 OS=Homo sapiens OX=9606 GN=SDCBP PE=1 SV=1" "0.015" "False" "1.948" "2" "1" "1" "1" "298" "32.4" "7.53" "0.00" "1" "cell-cell signaling;cell organization and biogenesis;protein metabolism;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00595" "6386" "ENSG00000137575" "SDCBP" "B2R5Q7; B4DUH3; B7ZLN2; O00173; O00560; O43391; Q14CP2" "Ectoderm differentiation; Ectoderm differentiation; VEGFA-VEGFR2 signaling; 11p11.2 copy number variation syndrome" "Neutrophil degranulation; Ephrin signaling; Neurofascin interactions; Regulation of necroptotic cell death" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4201306815623007207" "False" "Medium" "IsMasterProtein" "Q659A1" "Little elongation complex subunit 2 OS=Homo sapiens OX=9606 GN=ICE2 PE=1 SV=2" "0.015" "False" "1.947" "1" "1" "1" "1" "982" "109.9" "7.09" "1.90" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10505" "79664" "ENSG00000128915" "ICE2" "B2RU08; hsa:79664; Q05CT1; Q3B7W6; Q63HP4; Q658Q0; Q659A1; Q68CN8; Q6IPW7; Q6UX23; Q71H65; Q96CY5; Q9HAA2" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8991505405555366750" "False" "Medium" "IsMasterProtein" "Q8TED0" "U3 small nucleolar RNA-associated protein 15 homolog OS=Homo sapiens OX=9606 GN=UTP15 PE=1 SV=3" "0.015" "False" "1.944" "1" "1" "1" "1" "518" "58.4" "9.11" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "" "Pf00400, Pf09384" "84135" "ENSG00000164338" "UTP15" "B4DU75; B4DXK8; hsa:84135; Q6IA60; Q8TED0; Q96E08; Q9H9F8" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "472644769200762840" "False" "Medium" "IsMasterProtein" "Q9UJK0" "18S rRNA aminocarboxypropyltransferase OS=Homo sapiens OX=9606 GN=TSR3 PE=1 SV=1" "0.015" "False" "1.943" "3" "1" "1" "1" "312" "33.6" "6.87" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol" "other molecular function" "Pf04034, Pf04068" "115939" "ENSG00000007520" "TSR3" "hsa:115939; Q6PJT8; Q9UJK0" "" "rRNA modification in the nucleus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6548984541792378367" "False" "Medium" "IsMasterProtein" "Q9Y5Y2" "Cytosolic Fe-S cluster assembly factor NUBP2 OS=Homo sapiens OX=9606 GN=NUBP2 PE=1 SV=1" "0.015" "False" "1.936" "4" "1" "2" "1" "271" "28.8" "5.83" "4.84" "1" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10609" "10101" "ENSG00000095906" "NUBP2" "D3DU80; hsa:10101; Q9NWB2; Q9Y5Y2" "Iron-sulfur cluster biogenesis" "Cytosolic iron-sulfur cluster assembly" "2" "0" "1.403" "1.155" "1.590" "1.332" "1.127" "1.346" "1.095" "1.166" "1.144" "80.0" "112.2" "92.3" "127.2" "106.5" "90.1" "107.6" "87.5" "93.2" "91.4" "" "" "" "" "" "" "" "" "" "" "74.9" "92.8" "85.7" "98.3" "90.8" "86.1" "98.3" "77.7" "93.2" "88.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8697887679993430442" "False" "Medium" "IsMasterProtein" "Q8IYH5" "ZZ-type zinc finger-containing protein 3 OS=Homo sapiens OX=9606 GN=ZZZ3 PE=1 SV=1" "0.015" "False" "1.936" "1" "1" "1" "1" "903" "102.0" "5.69" "2.95" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00569" "26009" "ENSG00000036549" "ZZZ3" "B7WPC6; hsa:26009; Q6N004; Q6N070; Q8IYH5; Q8IYP0; Q8IYR1; Q8TEK4; Q9Y4U0" "" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "2" "0" "1.001" "1.028" "1.050" "1.024" "1.042" "0.988" "0.960" "0.938" "0.970" "183.3" "183.5" "188.4" "192.3" "187.7" "191.0" "181.0" "175.9" "171.9" "177.7" "" "" "" "" "" "" "" "" "" "" "171.7" "151.8" "174.9" "148.7" "160.0" "182.5" "165.4" "156.2" "171.9" "171.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-949132700508493695" "False" "Medium" "IsMasterProtein" "Q8WW59" "SPRY domain-containing protein 4 OS=Homo sapiens OX=9606 GN=SPRYD4 PE=1 SV=3" "0.016" "False" "1.931" "3" "1" "1" "1" "207" "23.1" "6.93" "2.13" "1" "" "nucleus" "" "Pf00622" "283377" "ENSG00000176422" "SPRYD4" "A8K7A5; hsa:283377; Q8WW59" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1801185171268448485" "False" "Medium" "IsMasterProtein" "Q6NTE8" "MRN complex-interacting protein OS=Homo sapiens OX=9606 GN=MRNIP PE=1 SV=2" "0.016" "False" "1.931" "3" "1" "1" "1" "343" "37.7" "8.66" "2.45" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf15749" "51149" "ENSG00000161010; ENSG00000283918" "MRNIP" "B5MD09; E9PAK6; Q6NTE8; Q7Z3D8; Q9BUC1; Q9UN54" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6680775627371570044" "False" "Medium" "IsMasterProtein" "Q9Y6V0" "Protein piccolo OS=Homo sapiens OX=9606 GN=PCLO PE=1 SV=5" "0.016" "False" "1.928" "0" "1" "4" "1" "5142" "560.4" "6.47" "9.99" "1" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00168, Pf00595, Pf05715" "27445" "ENSG00000186472" "PCLO" "A4D1A7; A6NNX9; O43373; O60305; Q08E72; Q9BVC8; Q9UIV2; Q9Y6U9; Q9Y6V0" "Cell lineage map for neuronal differentiation" "Sensory processing of sound by inner hair cells of the cochlea" "2" "0" "0.949" "1.038" "0.915" "1.000" "1.038" "1.046" "0.913" "0.993" "0.898" "185.8" "176.4" "192.9" "170.1" "185.8" "192.9" "194.4" "169.6" "184.6" "166.8" "" "" "" "" "" "" "" "" "" "" "174.1" "146.0" "179.1" "131.5" "158.3" "184.3" "177.6" "150.6" "184.6" "160.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1479259144489451223" "False" "Medium" "IsMasterProtein" "Q96DG6" "Carboxymethylenebutenolidase homolog OS=Homo sapiens OX=9606 GN=CMBL PE=1 SV=1" "0.016" "False" "1.927" "3" "1" "1" "1" "245" "28.0" "7.18" "3.16" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf01738" "134147" "ENSG00000164237" "CMBL" "D3DTC7; hsa:134147; Q8TED6; Q96DG6" "" "Phase I - Functionalization of compounds" "1" "0" "0.970" "1.017" "0.975" "0.975" "0.974" "1.008" "1.007" "0.961" "0.940" "209.4" "203.1" "212.9" "204.1" "204.1" "203.9" "211.1" "210.8" "201.2" "196.9" "" "" "" "" "" "" "" "" "" "" "196.2" "168.1" "197.6" "157.8" "174.0" "194.8" "192.9" "187.2" "201.2" "189.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5978102986579792947" "False" "Medium" "IsMasterProtein" "Q69YL0" "Protein NCBP2AS2 OS=Homo sapiens OX=9606 GN=NCBP2AS2 PE=1 SV=1" "0.016" "False" "1.926" "9" "1" "1" "1" "99" "10.9" "12.00" "2.73" "1" "" "" "" "" "" "ENSG00000270170" "NCBP2AS2" "Q69YL0" "3q29 copy number variation syndrome" "" "1" "0" "0.873" "0.926" "0.934" "0.944" "0.990" "1.000" "0.866" "1.453" "0.867" "64.9" "56.7" "60.1" "60.7" "61.3" "64.3" "64.9" "56.2" "94.4" "56.3" "" "" "" "" "" "" "" "" "" "" "60.8" "46.9" "55.8" "46.9" "52.3" "61.4" "59.3" "49.9" "94.4" "54.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5986646952840969808" "False" "Medium" "IsMasterProtein" "Q9BUE6" "Iron-sulfur cluster assembly 1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=ISCA1 PE=1 SV=1" "0.016" "False" "1.923" "9" "1" "1" "1" "129" "14.2" "9.07" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01521" "81689" "ENSG00000135070" "ISCA1" "B3KP34; B4DJI5; hsa:81689; Q8ND75; Q9BUE6; Q9BZR2" "" "Mitochondrial iron-sulfur cluster biogenesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8184976527645465360" "False" "Medium" "IsMasterProtein" "Q8N5M4" "Tetratricopeptide repeat protein 9C OS=Homo sapiens OX=9606 GN=TTC9C PE=1 SV=1" "0.016" "False" "1.922" "5" "1" "1" "1" "171" "20.0" "8.92" "2.47" "1" "" "" "" "Pf14559" "283237" "ENSG00000162222" "TTC9C" "hsa:283237; Q8N5M4; Q8WYY7" "" "" "0" "0" "0.846" "1.059" "0.997" "1.092" "1.062" "0.942" "1.160" "1.018" "1.028" "140.1" "118.6" "148.4" "139.6" "152.9" "148.7" "131.9" "162.5" "142.5" "144.0" "" "" "" "" "" "" "" "" "" "" "131.2" "98.1" "137.8" "107.9" "130.3" "142.1" "120.5" "144.3" "142.5" "138.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5401388015032906251" "False" "Medium" "IsMasterProtein" "O95402" "Mediator of RNA polymerase II transcription subunit 26 OS=Homo sapiens OX=9606 GN=MED26 PE=1 SV=2" "0.016" "False" "1.918" "1" "1" "1" "1" "600" "65.4" "9.16" "2.70" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf08711, Pf15693, Pf15694" "9441" "ENSG00000105085" "MED26" "A1A4S3; hsa:9441; O95402; Q0VGB6" "" "Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-45093919059166366" "False" "Medium" "IsMasterProtein" "O96018" "Amyloid-beta A4 precursor protein-binding family A member 3 OS=Homo sapiens OX=9606 GN=APBA3 PE=1 SV=1" "0.016" "False" "1.918" "2" "1" "1" "1" "575" "61.4" "4.94" "1.77" "1" "cell-cell signaling;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00595, Pf00640" "9546" "ENSG00000011132" "APBA3" "hsa:9546; O60483; O96018; Q9UPZ2" "" "Neurexins and neuroligins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3564973388906415615" "False" "Medium" "IsMasterProtein" "Q96DY7" "Mdm2-binding protein OS=Homo sapiens OX=9606 GN=MTBP PE=1 SV=1" "0.017" "False" "1.918" "1" "1" "1" "1" "904" "102.1" "7.77" "2.05" "1" "cell cycle OR cell proliferation;other biological processes" "other cell component" "" "Pf14918, Pf14919, Pf14920" "27085" "ENSG00000172167" "MTBP" "B4DUR5; hsa:27085; Q96DY7; Q9HA89" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9140529599078665748" "False" "Medium" "IsMasterProtein" "Q8NE28" "Serine/threonine kinase-like domain-containing protein STKLD1 OS=Homo sapiens OX=9606 GN=STKLD1 PE=1 SV=5" "0.017" "False" "1.917" "2" "1" "1" "1" "680" "75.6" "5.27" "2.02" "1" "" "" "kinase activity;other molecular function" "Pf00069" "169436" "ENSG00000198870; ENSG00000281245" "STKLD1" "hsa:169436; Q5T8U8; Q6ZMP6; Q6ZMQ5; Q8NE28" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3150532128508731386" "False" "Medium" "IsMasterProtein" "O75554" "WW domain-binding protein 4 OS=Homo sapiens OX=9606 GN=WBP4 PE=1 SV=1" "0.017" "False" "1.915" "2" "1" "1" "1" "376" "42.5" "5.57" "3.34" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00397, Pf06220" "11193" "ENSG00000120688" "WBP4" "B7Z4M2; hsa:11193; O75554; Q32P29" "" "mRNA Splicing - Major Pathway" "1" "0" "0.989" "1.044" "0.980" "1.043" "1.051" "1.032" "1.054" "1.050" "0.985" "397.8" "393.5" "415.3" "389.8" "414.7" "418.1" "410.4" "419.4" "417.5" "391.6" "" "" "" "" "" "" "" "" "" "" "372.7" "325.6" "385.5" "301.3" "353.5" "399.5" "375.0" "372.4" "417.5" "377.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2009028340265945261" "False" "Medium" "IsMasterProtein" "Q5QJE6" "Deoxynucleotidyltransferase terminal-interacting protein 2 OS=Homo sapiens OX=9606 GN=DNTTIP2 PE=1 SV=2" "0.017" "False" "1.909" "1" "1" "1" "1" "756" "84.4" "6.16" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf08698" "30836" "ENSG00000067334" "DNTTIP2" "hsa:30836; Q12987; Q53H59; Q5QJE6; Q5TFJ4; Q6TLI0; Q76MJ8; Q86WX9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6012550924560015135" "False" "Medium" "IsMasterProtein" "O43805" "Microtubule nucleation factor SSNA1 OS=Homo sapiens OX=9606 GN=SSNA1 PE=1 SV=2" "0.017" "False" "1.909" "6" "1" "2" "1" "119" "13.6" "5.38" "5.55" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "8636" "ENSG00000176101" "SSNA1" "hsa:8636; O43805; Q5VSG0; Q6FG70; Q9BVW8" "Ciliary landscape" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "8" "0" "1.111" "0.972" "1.094" "0.970" "0.992" "0.887" "0.957" "0.926" "0.993" "246.8" "274.2" "239.8" "269.9" "239.5" "244.8" "218.9" "236.1" "228.4" "245.1" "" "" "" "" "" "" "" "" "" "" "231.3" "226.9" "222.6" "208.7" "204.1" "233.9" "200.0" "209.6" "228.4" "236.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4872124519361806264" "False" "Medium" "IsMasterProtein" "Q9H1P3" "Oxysterol-binding protein-related protein 2 OS=Homo sapiens OX=9606 GN=OSBPL2 PE=1 SV=1" "0.017" "False" "1.903" "1" "1" "1" "1" "480" "55.2" "6.35" "2.90" "1" "cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf01237" "9885" "ENSG00000130703" "OSBPL2" "A8K736; hsa:9885; Q6IBT0; Q9BZB1; Q9H1P3; Q9Y4B8" "" "Synthesis of bile acids and bile salts" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7829507115951982075" "False" "Medium" "IsMasterProtein" "P19387" "DNA-directed RNA polymerase II subunit RPB3 OS=Homo sapiens OX=9606 GN=POLR2C PE=1 SV=2" "0.017" "False" "1.901" "3" "1" "1" "1" "275" "31.4" "4.92" "2.93" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01000, Pf01193" "5432" "ENSG00000102978" "POLR2C" "hsa:5432; O15161; P19387" "Pyrimidine metabolism; Eukaryotic transcription initiation; Primary ovarian insufficiency" "RNA polymerase II transcribes snRNA genes; TP53 Regulates Transcription of DNA Repair Genes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "44" "0" "1.091" "1.005" "0.975" "0.814" "0.958" "0.917" "0.861" "0.909" "0.887" "276.5" "301.5" "278.0" "269.6" "225.1" "264.8" "253.4" "237.9" "251.3" "245.3" "" "" "" "" "" "" "" "" "" "" "259.1" "249.5" "258.0" "208.4" "191.9" "253.0" "231.6" "211.3" "251.3" "236.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9033266282732166818" "False" "Medium" "IsMasterProtein" "Q9Y663" "Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 OS=Homo sapiens OX=9606 GN=HS3ST3A1 PE=1 SV=1" "0.018" "False" "1.899" "2" "1" "3" "1" "406" "44.9" "9.50" "8.01" "1" "protein metabolism;other metabolic processes;developmental processes" "other membranes;ER/Golgi" "other molecular function" "Pf00685" "9955" "ENSG00000153976" "HS3ST3A1" "A8K7N2; hsa:9955; Q9Y663" "Glycosaminoglycan synthesis in fibroblasts; Metapathway biotransformation Phase I and II" "HS-GAG biosynthesis" "3" "0" "0.730" "0.994" "1.007" "0.959" "0.767" "0.943" "0.875" "0.854" "0.926" "112.4" "82.1" "111.7" "113.1" "107.8" "86.2" "106.0" "98.3" "95.9" "104.0" "" "" "" "" "" "" "" "" "" "" "105.3" "67.9" "103.7" "87.5" "91.9" "82.4" "96.9" "87.3" "95.9" "100.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1508520099069387259" "False" "Medium" "IsMasterProtein" "E5RJM6" "Ankyrin repeat domain-containing protein 65 OS=Homo sapiens OX=9606 GN=ANKRD65 PE=1 SV=2" "0.018" "False" "1.899" "2" "1" "1" "1" "399" "41.5" "6.57" "2.48" "1" "" "" "" "Pf12796, Pf13637" "441869" "ENSG00000235098" "ANKRD65" "E5RJM6; hsa:441869; J3KR93" "1p36 copy number variation syndrome" "" "1" "0" "0.833" "0.868" "0.980" "1.028" "0.867" "0.951" "0.952" "0.881" "0.932" "171.1" "142.4" "148.6" "167.7" "175.8" "148.3" "162.7" "162.8" "150.6" "159.5" "" "" "" "" "" "" "" "" "" "" "160.3" "117.8" "137.9" "129.6" "149.8" "141.7" "148.7" "144.5" "150.6" "153.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2337830748365545884" "False" "Medium" "IsMasterProtein" "Q53FT3" "Protein Hikeshi OS=Homo sapiens OX=9606 GN=HIKESHI PE=1 SV=2" "0.018" "False" "1.897" "4" "1" "1" "1" "197" "21.6" "5.45" "2.69" "1" "cell organization and biogenesis;stress response;transport;developmental processes" "cytosol;nucleus" "other molecular function" "Pf05603, Pf21057" "51501" "ENSG00000149196" "HIKESHI" "hsa:51501; Q53FT3; Q8WVE8; Q9NVQ2; Q9NZZ1; Q9P022; Q9P0N1" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9115866675213369101" "False" "Medium" "IsMasterProtein" "Q99807" "5-demethoxyubiquinone hydroxylase, mitochondrial OS=Homo sapiens OX=9606 GN=COQ7 PE=1 SV=3" "0.018" "False" "1.896" "5" "1" "2" "1" "217" "24.3" "8.59" "0.00" "1" "other metabolic processes;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf03232" "10229" "ENSG00000167186" "COQ7" "B2RDA9; hsa:10229; Q99807; Q9BTT7; Q9H0T5; Q9UEW5; Q9UNR5" "" "Ubiquinol biosynthesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2874212812822634582" "False" "Medium" "IsMasterProtein" "Q7Z3T8" "Zinc finger FYVE domain-containing protein 16 OS=Homo sapiens OX=9606 GN=ZFYVE16 PE=1 SV=3" "0.018" "False" "1.894" "1" "1" "2" "1" "1539" "168.8" "4.82" "5.24" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf11979" "9765" "ENSG00000039319" "ZFYVE16" "hsa:9765; O15023; Q5H9U2; Q7LAU7; Q7Z3T8; Q86T69; Q8N5L3; Q8NEK3" "TGF-beta signaling pathway" "Signaling by BMP" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9157020147431294409" "False" "Medium" "IsMasterProtein" "P17028" "Zinc finger protein 24 OS=Homo sapiens OX=9606 GN=ZNF24 PE=1 SV=4" "0.018" "False" "1.894" "2" "1" "1" "1" "368" "42.1" "6.21" "2.71" "1" "developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf02023" "7572" "ENSG00000172466" "ZNF24" "hsa:7572; O14754; P17028; Q53YE4; Q6ICR5; Q8IZN4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6317134454260783883" "False" "Medium" "IsMasterProtein" "P28290" "Protein ITPRID2 OS=Homo sapiens OX=9606 GN=ITPRID2 PE=1 SV=3" "0.018" "False" "1.894" "1" "1" "1" "1" "1259" "138.3" "5.19" "2.64" "1" "" "plasma membrane;other membranes;cytosol;nucleus" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf14722, Pf14723" "6744" "ENSG00000138434" "ITPRID2" "A8K6T0; hsa:6744; P28290; Q68DA6; Q7Z7L2; Q8N1L3; Q8N263; Q8N7H2; Q8NEN5; Q96E36; Q96PW1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3784875960281055954" "False" "Medium" "IsMasterProtein" "O00311" "Cell division cycle 7-related protein kinase OS=Homo sapiens OX=9606 GN=CDC7 PE=1 SV=1" "0.018" "False" "1.892" "1" "1" "1" "1" "574" "63.8" "8.73" "1.63" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8317" "ENSG00000097046" "CDC7" "D3DT31; hsa:8317; O00311; O00558; Q5T5U5" "Cell cycle; Retinoblastoma gene in cancer; DNA replication" "Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Transcriptional Regulation by E2F6" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2487485535113900715" "False" "Medium" "IsMasterProtein" "Q9UGK8" "Secretion-regulating guanine nucleotide exchange factor OS=Homo sapiens OX=9606 GN=SERGEF PE=1 SV=2" "0.018" "False" "1.892" "2" "1" "1" "1" "458" "49.0" "6.46" "2.35" "1" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf00415, Pf13540" "26297" "ENSG00000129158" "SERGEF" "hsa:26297; Q9UGK8; Q9UGK9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6600262184831849925" "False" "Medium" "IsMasterProtein" "Q9P086" "Mediator of RNA polymerase II transcription subunit 11 OS=Homo sapiens OX=9606 GN=MED11 PE=1 SV=2" "0.018" "False" "1.891" "6" "1" "1" "1" "117" "13.1" "5.96" "2.70" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10280" "400569" "ENSG00000161920" "MED11" "hsa:400569; Q6NS89; Q9P086" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "3" "0" "0.957" "0.878" "1.129" "0.919" "1.054" "1.002" "0.936" "1.040" "1.030" "342.3" "327.6" "300.5" "386.5" "314.6" "360.8" "343.0" "320.3" "355.9" "352.7" "" "" "" "" "" "" "" "" "" "" "320.8" "271.1" "279.0" "298.8" "268.1" "344.7" "313.4" "284.4" "355.9" "339.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6412090478534982987" "False" "Medium" "IsMasterProtein" "Q9BVI0" "PHD finger protein 20 OS=Homo sapiens OX=9606 GN=PHF20 PE=1 SV=2" "0.018" "False" "1.889" "1" "1" "1" "1" "1012" "115.3" "6.99" "2.64" "1" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12618, Pf18115, Pf20826" "51230" "ENSG00000025293" "PHF20" "A7E235; B2RB56; E1P5S3; hsa:51230; Q566Q2; Q5JWY9; Q66K49; Q9BVI0; Q9BWV4; Q9BXA3; Q9BZW3; Q9H421; Q9H4J6; Q9NZ22" "IL-18 signaling pathway" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones; Regulation of TP53 Degradation; Stabilization of p53; Regulation of TP53 Activity through Association with Co-factors" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6303332462308628979" "False" "Medium" "IsMasterProtein" "Q9NYY3" "Serine/threonine-protein kinase PLK2 OS=Homo sapiens OX=9606 GN=PLK2 PE=1 SV=3" "0.018" "False" "1.889" "1" "1" "1" "1" "685" "78.2" "8.24" "2.68" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00659" "10769" "ENSG00000145632" "PLK2" "hsa:10769; O60679; Q96CV7; Q9NYY3; Q9UE61" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; NPAS4 regulates expression of target genes; CD163 mediating an anti-inflammatory response" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5417947325093162762" "False" "Medium" "IsMasterProtein" "Q49A26" "Cytokine-like nuclear factor N-PAC OS=Homo sapiens OX=9606 GN=GLYR1 PE=1 SV=4" "0.018" "False" "1.888" "1" "1" "1" "1" "553" "60.5" "9.17" "2.88" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00855, Pf03446, Pf14833" "84656" "ENSG00000140632" "GLYR1" "B4DL47; C9JJ40; C9JJ60; hsa:84656; Q49A26; Q5U632; Q6P1Q2; Q6V3W7; Q9BTI1; Q9BXK2" "" "" "0" "0" "1.142" "1.110" "1.230" "1.172" "1.091" "1.584" "1.140" "1.038" "1.049" "75.9" "86.7" "84.2" "93.3" "88.9" "82.8" "120.2" "86.5" "78.8" "79.6" "" "" "" "" "" "" "" "" "" "" "71.1" "71.7" "78.2" "72.2" "75.8" "79.1" "109.8" "76.8" "78.8" "76.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7945437556686127836" "False" "Medium" "IsMasterProtein" "Q96GA3" "Protein LTV1 homolog OS=Homo sapiens OX=9606 GN=LTV1 PE=1 SV=1" "0.018" "False" "1.884" "1" "1" "1" "1" "475" "54.8" "4.91" "2.65" "1" "transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04180" "84946" "ENSG00000135521" "LTV1" "hsa:84946; Q96GA3; Q96JX8" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.056" "1.002" "1.039" "1.152" "1.039" "1.443" "1.349" "1.360" "1.129" "299.5" "316.2" "300.0" "311.1" "345.0" "311.2" "432.1" "404.0" "407.3" "338.0" "" "" "" "" "" "" "" "" "" "" "280.6" "261.6" "278.5" "240.5" "294.1" "297.4" "394.8" "358.7" "407.3" "325.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8611870974223822516" "False" "Medium" "IsMasterProtein" "Q8NHP8" "Putative phospholipase B-like 2 OS=Homo sapiens OX=9606 GN=PLBD2 PE=1 SV=2" "0.018" "False" "1.883" "1" "1" "1" "1" "589" "65.4" "6.80" "2.34" "1" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle" "other molecular function" "Pf04916" "196463" "ENSG00000151176" "PLBD2" "F5H5E2; hsa:196463; Q8NHP8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6648624995345891134" "False" "Medium" "IsMasterProtein" "Q96T23" "Remodeling and spacing factor 1 OS=Homo sapiens OX=9606 GN=RSF1 PE=1 SV=2" "0.018" "False" "1.881" "0" "1" "1" "1" "1441" "163.7" "5.01" "2.42" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00628, Pf15612" "51773" "ENSG00000048649" "RSF1" "hsa:51773; Q86X86; Q96T23; Q9H3L8; Q9NVZ8; Q9NYU0" "" "Deposition of new CENPA-containing nucleosomes at the centromere" "1" "0" "1.039" "1.022" "1.182" "1.191" "1.089" "1.564" "1.496" "1.473" "1.169" "258.4" "268.6" "264.1" "305.5" "307.7" "281.5" "404.1" "386.6" "380.6" "302.1" "" "" "" "" "" "" "" "" "" "" "242.2" "222.3" "245.2" "236.2" "262.3" "269.0" "369.3" "343.3" "380.6" "290.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4670744058278942272" "False" "Medium" "IsMasterProtein" "Q9UN74" "Protocadherin alpha-4 OS=Homo sapiens OX=9606 GN=PCDHA4 PE=1 SV=1" "0.018" "False" "1.881" "1" "1" "1" "1" "947" "102.2" "5.08" "2.52" "1" "cell adhesion;developmental processes" "plasma membrane;other membranes" "other molecular function" "Pf00028, Pf08266, Pf15974" "56144" "ENSG00000204967; ENSG00000291652" "PCDHA4" "hsa:56144; O75285; Q2M253; Q9UN74" "GDNF signaling" "" "1" "0" "1.153" "1.166" "1.450" "1.242" "1.130" "1.292" "1.255" "1.191" "1.179" "79.2" "91.2" "92.3" "114.8" "98.3" "89.4" "102.3" "99.4" "94.3" "93.4" "" "" "" "" "" "" "" "" "" "" "74.2" "75.5" "85.7" "88.7" "83.8" "85.4" "93.4" "88.2" "94.3" "89.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-288678854882700202" "False" "Medium" "IsMasterProtein" "Q7Z3C6" "Autophagy-related protein 9A OS=Homo sapiens OX=9606 GN=ATG9A PE=1 SV=3" "0.018" "False" "1.880" "1" "1" "1" "1" "839" "94.4" "6.67" "3.13" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity" "Pf04109" "79065" "ENSG00000198925" "ATG9A" "hsa:79065; Q3ZAQ6; Q6P0N7; Q7Z317; Q7Z320; Q7Z3C6; Q8NDK6; Q8WU65; Q9BVL5; Q9H6L1; Q9HAG7" "Autophagy; Primary ovarian insufficiency" "Macroautophagy" "3" "0" "0.984" "1.089" "0.950" "0.941" "0.993" "1.107" "1.030" "1.041" "0.853" "63.3" "62.3" "68.9" "60.1" "59.6" "62.8" "70.0" "65.2" "65.9" "53.9" "" "" "" "" "" "" "" "" "" "" "59.3" "51.5" "64.0" "46.5" "50.8" "60.0" "64.0" "57.9" "65.9" "51.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6208634135307330971" "False" "Medium" "IsMasterProtein" "P17480" "Nucleolar transcription factor 1 OS=Homo sapiens OX=9606 GN=UBTF PE=1 SV=1" "0.019" "False" "1.875" "1" "1" "1" "1" "764" "89.4" "5.81" "2.04" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505, Pf09011, Pf14887" "7343" "ENSG00000108312" "UBTF" "A8K6R8; hsa:7343; P17480" "Ectoderm differentiation" "NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; RNA Polymerase I Promoter Opening" "6" "0" "1.033" "1.022" "1.044" "1.014" "0.995" "1.120" "1.145" "1.141" "1.011" "311.4" "321.8" "318.2" "325.2" "315.7" "309.9" "348.6" "356.5" "355.3" "315.0" "" "" "" "" "" "" "" "" "" "" "291.8" "266.3" "295.4" "251.4" "269.1" "296.1" "318.6" "316.6" "355.3" "303.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7407118807577494974" "False" "Medium" "IsMasterProtein" "Q5VST6" "Alpha/beta hydrolase domain-containing protein 17B OS=Homo sapiens OX=9606 GN=ABHD17B PE=1 SV=1" "0.019" "False" "1.873" "3" "1" "2" "1" "288" "32.2" "6.29" "5.36" "1" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00326" "51104" "ENSG00000107362" "ABHD17B" "A8KAJ5; hsa:51104; Q5VST6; Q5VST7; Q86YB6; Q8IY03; Q9Y377" "" "RAS processing" "1" "0" "1.034" "1.147" "1.169" "1.083" "1.137" "1.134" "0.928" "1.047" "1.221" "55.7" "57.6" "63.9" "65.1" "60.3" "63.3" "63.2" "51.7" "58.3" "68.0" "" "" "" "" "" "" "" "" "" "" "52.2" "47.6" "59.3" "50.3" "51.4" "60.5" "57.7" "45.9" "58.3" "65.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5221985020490519737" "False" "Medium" "IsMasterProtein" "Q6PJI9" "GATOR2 complex protein WDR59 OS=Homo sapiens OX=9606 GN=WDR59 PE=1 SV=2" "0.019" "False" "1.871" "1" "1" "1" "1" "974" "109.7" "7.91" "3.08" "1" "stress response;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400, Pf17120" "79726" "ENSG00000103091" "WDR59" "B3KRC3; hsa:79726; Q6PJI9; Q71RE7; Q96PW5; Q9BSW6; Q9HA43" "" "Amino acids regulate mTORC1" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7155113845635909290" "False" "Medium" "IsMasterProtein" "P61601" "Neurocalcin-delta OS=Homo sapiens OX=9606 GN=NCALD PE=1 SV=2" "0.019" "False" "1.867" "4" "1" "1" "1" "193" "22.2" "5.35" "2.67" "1" "transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi" "cytoskeletal activity;other molecular function" "Pf00036, Pf13499" "83988" "ENSG00000104490" "NCALD" "hsa:83988; P29554; P61601; Q8IYC3; Q9H0W2" "" "Activation of Ca-permeable Kainate Receptor" "1" "0" "1.190" "1.047" "1.234" "1.178" "0.984" "1.244" "1.127" "1.071" "1.146" "73.4" "87.3" "76.8" "90.6" "86.4" "72.2" "91.3" "82.7" "78.6" "84.1" "" "" "" "" "" "" "" "" "" "" "68.8" "72.3" "71.3" "70.0" "73.7" "69.0" "83.4" "73.4" "78.6" "81.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-470190640123372826" "False" "Medium" "IsMasterProtein" "Q8WXD2" "Secretogranin-3 OS=Homo sapiens OX=9606 GN=SCG3 PE=1 SV=3" "0.019" "False" "1.866" "1" "1" "1" "1" "468" "53.0" "5.03" "3.29" "1" "other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "" "Pf15467" "29106" "ENSG00000104112" "SCG3" "A8K2B0; B3KQP6; B4DK99; F5H3R8; hsa:29106; Q8WXD2; Q96C83; Q96GE8; Q9Y6G7" "" "Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-557938848526159957" "False" "Medium" "IsMasterProtein" "Q8IWB9" "Testis-expressed protein 2 OS=Homo sapiens OX=9606 GN=TEX2 PE=1 SV=2" "0.019" "False" "1.859" "1" "1" "1" "1" "1127" "125.2" "6.01" "0.00" "1" "other metabolic processes;transport;signal transduction" "other membranes;ER/Golgi;nucleus" "other molecular function" "" "55852" "ENSG00000136478" "TEX2" "hsa:55852; Q6AHZ5; Q8IWB9; Q8N3L0; Q9C0C5" "" "RHOA GTPase cycle" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6582781220812182564" "False" "Medium" "IsMasterProtein" "Q9NX70" "Mediator of RNA polymerase II transcription subunit 29 OS=Homo sapiens OX=9606 GN=MED29 PE=1 SV=1" "0.019" "False" "1.857" "4" "1" "1" "1" "200" "21.1" "6.29" "2.58" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11568" "55588" "ENSG00000063322" "MED29" "B4DNQ6; hsa:55588; M0R2E4; Q5XX09; Q9NTF4; Q9NX70" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "3" "0" "1.149" "1.050" "1.071" "1.147" "1.025" "1.015" "0.982" "1.022" "1.006" "88.0" "101.2" "92.4" "94.3" "101.0" "90.2" "89.4" "86.4" "89.9" "88.5" "" "" "" "" "" "" "" "" "" "" "82.5" "83.7" "85.8" "72.9" "86.1" "86.2" "81.7" "76.8" "89.9" "85.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4117070045163199408" "False" "Medium" "IsMasterProtein" "Q6NUQ1" "RAD50-interacting protein 1 OS=Homo sapiens OX=9606 GN=RINT1 PE=1 SV=1" "0.019" "False" "1.857" "1" "1" "1" "1" "792" "90.6" "5.45" "2.62" "1" "cell cycle OR cell proliferation;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf04437" "60561" "ENSG00000135249" "RINT1" "hsa:60561; Q6NUQ1; Q75MG9; Q75MH0; Q96IW8; Q9H229; Q9HAD9" "" "COPI-dependent Golgi-to-ER retrograde traffic" "1" "0" "0.965" "0.945" "1.046" "1.002" "0.912" "1.112" "0.917" "0.936" "1.014" "198.1" "191.2" "187.2" "207.2" "198.5" "180.6" "220.2" "181.7" "185.4" "200.9" "" "" "" "" "" "" "" "" "" "" "185.6" "158.2" "173.8" "160.2" "169.2" "172.5" "201.2" "161.3" "185.4" "193.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8390482752338530718" "False" "Medium" "IsMasterProtein" "Q8N9V7" "Protein TOPAZ1 OS=Homo sapiens OX=9606 GN=TOPAZ1 PE=1 SV=3" "0.019" "False" "1.854" "0" "1" "1" "1" "1692" "190.8" "7.87" "2.33" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol" "" "Pf14669" "375337" "ENSG00000173769" "TOPAZ1" "hsa:375337; Q8N9V7" "" "" "0" "0" "0.991" "1.047" "1.049" "1.030" "1.077" "1.079" "1.011" "0.927" "1.099" "244.6" "242.5" "256.1" "256.7" "252.0" "263.3" "263.9" "247.3" "226.9" "268.7" "" "" "" "" "" "" "" "" "" "" "229.2" "200.6" "237.7" "198.4" "214.8" "251.6" "241.1" "219.5" "226.9" "258.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-448736336253279631" "False" "Medium" "IsMasterProtein" "Q9Y2H0" "Disks large-associated protein 4 OS=Homo sapiens OX=9606 GN=DLGAP4 PE=1 SV=3" "0.019" "False" "1.853" "1" "1" "1" "1" "992" "107.9" "7.08" "2.64" "1" "other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf03359" "22839" "ENSG00000080845" "DLGAP4" "E1P5T5; hsa:22839; Q5QPG4; Q5T2Y4; Q5T2Y5; Q9H137; Q9H138; Q9H1L7; Q9Y2H0" "" "Neurexins and neuroligins" "1" "0" "1.097" "1.127" "0.987" "0.932" "1.070" "1.025" "1.064" "1.018" "1.000" "148.4" "162.9" "167.3" "146.5" "138.3" "158.8" "152.2" "157.9" "151.1" "148.4" "" "" "" "" "" "" "" "" "" "" "139.1" "134.8" "155.3" "113.2" "117.9" "151.7" "139.0" "140.2" "151.1" "142.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4274550233442201584" "False" "Medium" "IsMasterProtein" "Q5TC63" "Growth hormone-regulated TBC protein 1 OS=Homo sapiens OX=9606 GN=GRTP1 PE=1 SV=4" "0.019" "False" "1.852" "2" "1" "1" "1" "336" "38.5" "8.78" "2.66" "1" "" "" "enzyme regulator activity" "Pf00566" "79774" "ENSG00000139835" "GRTP1" "B9A6K2; hsa:79774; Q2M232; Q5TC63; Q5TC64; Q66K26; Q6P659; Q8N528; Q9H695" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4549046662216953457" "False" "Medium" "IsMasterProtein" "Q86XN7" "Proline and serine-rich protein 1 OS=Homo sapiens OX=9606 GN=PROSER1 PE=1 SV=2" "0.019" "False" "1.851" "1" "1" "1" "1" "944" "95.6" "8.88" "1.91" "1" "" "" "" "Pf14771" "80209" "ENSG00000120685" "PROSER1" "A6NJ97; hsa:80209; Q6P2S2; Q7Z3X5; Q86XN7; Q8N3D2; Q8N3P1; Q9H9M1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5777043105444546084" "False" "Medium" "IsMasterProtein" "P00387" "NADH-cytochrome b5 reductase 3 OS=Homo sapiens OX=9606 GN=CYB5R3 PE=1 SV=3" "0.020" "False" "1.844" "4" "1" "1" "1" "301" "34.2" "7.59" "0.00" "1" "other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00175, Pf00970" "1727" "ENSG00000100243" "CYB5R3" "B1AHF2; B7Z7L3; hsa:1727; O75675; P00387; Q8TDL8; Q8WTS8; Q9UEN4; Q9UEN5; Q9UL55; Q9UL56" "Oxidation by cytochrome P450" "Neutrophil degranulation; Phase I - Functionalization of compounds; Vitamin C (ascorbate) metabolism" "4" "0" "1.143" "0.905" "0.969" "1.019" "0.912" "0.982" "1.001" "0.886" "0.992" "70.4" "80.5" "63.8" "68.3" "71.8" "64.3" "69.2" "70.5" "62.4" "69.9" "" "" "" "" "" "" "" "" "" "" "66.0" "66.6" "59.2" "52.8" "61.2" "61.4" "63.2" "62.6" "62.4" "67.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7903736519056340786" "False" "Medium" "IsMasterProtein" "P53985" "Monocarboxylate transporter 1 OS=Homo sapiens OX=9606 GN=SLC16A1 PE=1 SV=3" "0.020" "False" "1.844" "2" "1" "1" "1" "500" "53.9" "8.66" "3.53" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "transporter activity;other molecular function" "" "6566" "ENSG00000155380; ENSG00000281917" "SLC16A1" "hsa:6566; P53985; Q49A45; Q5T8R6; Q9NSJ9" "Photodynamic therapy-induced HIF-1 survival signaling; Fragile X syndrome; Glucose metabolism in triple-negative breast cancer cells" "Pyruvate metabolism; Aspirin ADME; Basigin interactions; Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7327599600572382898" "False" "Medium" "IsMasterProtein" "P08473" "Neprilysin OS=Homo sapiens OX=9606 GN=MME PE=1 SV=2" "0.020" "False" "1.843" "1" "1" "1" "1" "750" "85.5" "5.73" "0.00" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01431, Pf05649" "4311" "ENSG00000196549" "MME" "A8K6U6; D3DNJ9; hsa:4311; P08473; Q3MIX4" "Alzheimer's disease and miRNA effects; Primary focal segmental glomerulosclerosis (FSGS); Alzheimer's disease" "Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins; Physiological factors" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9003778122824522310" "False" "Medium" "IsMasterProtein" "Q9BRT3" "Migration and invasion enhancer 1 OS=Homo sapiens OX=9606 GN=MIEN1 PE=1 SV=1" "0.020" "False" "1.835" "6" "1" "1" "1" "115" "12.4" "4.37" "2.97" "1" "other biological processes" "plasma membrane;other membranes;cytosol" "" "Pf10262" "84299" "ENSG00000141741" "MIEN1" "hsa:84299; Q9BRT3" "17q12 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8975526116360491970" "False" "Medium" "IsMasterProtein" "Q5SZK8" "FRAS1-related extracellular matrix protein 2 OS=Homo sapiens OX=9606 GN=FREM2 PE=1 SV=3" "0.020" "False" "1.835" "0" "1" "1" "1" "3169" "350.9" "5.03" "2.33" "1" "cell adhesion;developmental processes;other biological processes" "extracellular matrix;plasma membrane;other membranes" "other molecular function" "Pf03160, Pf16184, Pf19309" "341640" "ENSG00000150893" "FREM2" "hsa:341640; Q4QQG1; Q5H9N8; Q5SZK8; Q5T6Q1; Q6N057; Q6ZSB4; Q7Z305; Q7Z341" "Development of ureteric collection system" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "78901819500717128" "False" "Medium" "IsMasterProtein" "Q96AH0" "SOSS complex subunit B2 OS=Homo sapiens OX=9606 GN=NABP1 PE=1 SV=1" "0.020" "False" "1.835" "4" "1" "1" "1" "204" "22.4" "9.58" "2.30" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf21473" "64859" "ENSG00000173559" "NABP1" "hsa:64859; Q658Y8; Q96AH0; Q9H5X6" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "1.105" "1.085" "1.472" "1.267" "1.257" "1.088" "1.185" "1.073" "1.188" "57.9" "64.1" "62.8" "85.3" "73.4" "72.8" "63.1" "68.6" "62.2" "68.9" "" "" "" "" "" "" "" "" "" "" "54.3" "53.0" "58.3" "65.9" "62.6" "69.6" "57.6" "61.0" "62.2" "66.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4265573447895357549" "False" "Medium" "IsMasterProtein" "Q13625" "Apoptosis-stimulating of p53 protein 2 OS=Homo sapiens OX=9606 GN=TP53BP2 PE=1 SV=2" "0.020" "False" "1.834" "1" "1" "1" "1" "1128" "125.5" "6.07" "2.41" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00018, Pf00023, Pf21801" "7159" "ENSG00000143514" "TP53BP2" "B4DG66; hsa:7159; Q12892; Q13625; Q86X75; Q96KQ3" "" "TP53 Regulates Transcription of Death Receptors and Ligands; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; Regulation of TP53 Activity through Association with Co-factors" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3258131120717726760" "False" "Medium" "IsMasterProtein" "Q96EU6" "Ribosomal RNA processing protein 36 homolog OS=Homo sapiens OX=9606 GN=RRP36 PE=1 SV=1" "0.020" "False" "1.832" "3" "1" "1" "1" "259" "29.8" "10.17" "2.61" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf06102" "88745" "ENSG00000124541" "RRP36" "hsa:88745; Q96EU6; Q9BRF6; Q9P0C8" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3273725157349986493" "False" "Medium" "IsMasterProtein" "Q99698" "Lysosomal-trafficking regulator OS=Homo sapiens OX=9606 GN=LYST PE=1 SV=3" "0.020" "False" "1.831" "0" "1" "1" "1" "3801" "428.9" "6.61" "2.67" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;cytoskeleton" "other molecular function" "Pf00400, Pf02138, Pf14844" "1130" "ENSG00000143669" "LYST" "hsa:1130; O43274; Q5T2U9; Q96TD7; Q96TD8; Q99698; Q99709; Q9H133" "" "" "0" "0" "1.193" "1.160" "1.208" "1.244" "1.204" "1.145" "1.274" "1.230" "1.252" "159.3" "190.1" "184.8" "192.5" "198.1" "191.9" "182.4" "202.9" "195.9" "199.5" "" "" "" "" "" "" "" "" "" "" "149.3" "157.3" "171.6" "148.8" "168.9" "183.3" "166.6" "180.2" "195.9" "192.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8314538652520979745" "False" "Medium" "IsMasterProtein" "A5D8V6" "Vacuolar protein sorting-associated protein 37C OS=Homo sapiens OX=9606 GN=VPS37C PE=1 SV=2" "0.020" "False" "1.829" "2" "1" "1" "1" "355" "38.6" "5.21" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf07200" "55048" "ENSG00000167987" "VPS37C" "A5D8V6; hsa:55048; Q8N3K4" "7q11.23 copy number variation syndrome" "Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy" "6" "0" "1.052" "1.053" "1.197" "1.212" "1.140" "1.160" "1.144" "1.294" "1.223" "86.2" "90.7" "90.8" "103.2" "104.5" "98.3" "100.0" "98.6" "111.6" "105.5" "" "" "" "" "" "" "" "" "" "" "80.8" "75.1" "84.3" "79.8" "89.1" "93.9" "91.4" "87.5" "111.6" "101.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3889870800150504402" "False" "Medium" "IsMasterProtein" "Q8N5C8" "TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 OS=Homo sapiens OX=9606 GN=TAB3 PE=1 SV=3" "0.020" "False" "1.828" "1" "1" "1" "1" "712" "78.6" "8.54" "2.34" "1" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf02845" "257397" "ENSG00000157625" "TAB3" "A6NDD9; Q6VQR0; Q8N5C8" "IL-1 signaling pathway; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Toll-like receptor signaling pathway" "TAK1-dependent IKK and NF-kappa-B activation ; FCERI mediated NF-kB activation; CLEC7A (Dectin-1) signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TNFR1-induced NF-kappa-B signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8819989402744158112" "False" "Medium" "IsMasterProtein" "Q96EW2" "HSPB1-associated protein 1 OS=Homo sapiens OX=9606 GN=HSPBAP1 PE=1 SV=1" "0.020" "False" "1.826" "2" "1" "1" "1" "488" "55.1" "5.60" "2.95" "1" "" "other cell component" "other molecular function" "Pf13621" "79663" "ENSG00000169087" "HSPBAP1" "hsa:79663; Q6P476; Q8N8J4; Q8NHH6; Q8WWF0; Q96EW2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7985947186271226833" "False" "Medium" "IsMasterProtein" "Q9UPW0" "Forkhead box protein J3 OS=Homo sapiens OX=9606 GN=FOXJ3 PE=1 SV=2" "0.020" "False" "1.825" "1" "1" "1" "1" "622" "68.9" "7.09" "2.40" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250" "22887" "ENSG00000198815" "FOXJ3" "A7MBL7; A7MD18; D3DPW2; hsa:22887; Q9NSS7; Q9UPW0" "" "" "0" "0" "1.053" "1.103" "1.108" "1.147" "1.164" "1.128" "1.126" "1.074" "1.177" "299.5" "315.4" "330.4" "332.0" "343.7" "348.6" "337.9" "337.2" "321.8" "352.6" "" "" "" "" "" "" "" "" "" "" "280.6" "261.0" "306.8" "256.6" "292.9" "333.1" "308.8" "299.4" "321.8" "339.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2350188829608931465" "False" "Medium" "IsMasterProtein" "Q8TDD1" "ATP-dependent RNA helicase DDX54 OS=Homo sapiens OX=9606 GN=DDX54 PE=1 SV=2" "0.020" "False" "1.821" "1" "1" "1" "1" "881" "98.5" "10.02" "2.67" "1" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "ER/Golgi;nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf00270, Pf00271, Pf08147" "79039" "ENSG00000123064" "DDX54" "hsa:79039; Q86YT8; Q8TDD1; Q9BRZ1" "" "" "0" "0" "1.136" "1.009" "1.231" "1.117" "1.085" "1.086" "1.161" "1.135" "1.164" "74.6" "84.7" "75.3" "91.8" "83.3" "81.0" "81.0" "86.7" "84.7" "86.9" "" "" "" "" "" "" "" "" "" "" "69.9" "70.1" "69.9" "71.0" "71.0" "77.4" "74.1" "76.9" "84.7" "83.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7938684201688622214" "False" "Medium" "IsMasterProtein" "Q8NC96" "Adaptin ear-binding coat-associated protein 1 OS=Homo sapiens OX=9606 GN=NECAP1 PE=1 SV=2" "0.021" "False" "1.820" "3" "1" "1" "1" "275" "29.7" "6.80" "3.33" "1" "transport" "other membranes;cytosol" "" "Pf07933" "25977" "ENSG00000089818" "NECAP1" "hsa:25977; Q2NL73; Q5XG95; Q6NWY6; Q8N153; Q8NC96; Q8NCB0; Q9BU52; Q9Y407" "" "Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3814713572748988923" "False" "Medium" "IsMasterProtein" "Q6NW34" "Nucleolus and neural progenitor protein OS=Homo sapiens OX=9606 GN=NEPRO PE=1 SV=3" "0.021" "False" "1.819" "2" "1" "1" "1" "567" "64.5" "9.74" "0.00" "1" "other biological processes" "nucleus" "" "Pf14780" "25871" "ENSG00000163608" "NEPRO" "D3DN69; hsa:25871; Q68DM6; Q6NW34; Q9H7U0; Q9UFM4" "" "" "0" "0" "1.159" "1.053" "1.134" "1.318" "1.184" "1.218" "1.215" "1.167" "1.195" "117.4" "136.1" "123.6" "133.1" "154.8" "138.9" "142.9" "142.7" "137.0" "140.3" "" "" "" "" "" "" "" "" "" "" "110.0" "112.6" "114.8" "102.9" "131.9" "132.7" "130.6" "126.7" "137.0" "135.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "34707929049350531" "False" "Medium" "IsMasterProtein" "P51151" "Ras-related protein Rab-9A OS=Homo sapiens OX=9606 GN=RAB9A PE=1 SV=1" "0.021" "False" "1.810" "3" "1" "1" "1" "201" "22.8" "5.47" "2.97" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "9367" "ENSG00000123595" "RAB9A" "A8K390; hsa:9367; P51151; Q6ICN1" "Ebola virus infection in host; Measles virus infection" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle" "6" "0" "0.996" "1.000" "1.020" "0.930" "0.942" "1.159" "0.980" "0.941" "0.996" "285.0" "283.8" "285.1" "290.6" "265.1" "268.3" "330.3" "279.2" "268.1" "283.8" "" "" "" "" "" "" "" "" "" "" "267.0" "234.8" "264.7" "224.6" "226.0" "256.4" "301.8" "247.9" "268.1" "273.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6585156526220186140" "False" "Medium" "IsMasterProtein" "Q13610" "Periodic tryptophan protein 1 homolog OS=Homo sapiens OX=9606 GN=PWP1 PE=1 SV=1" "0.021" "False" "1.810" "1" "1" "1" "1" "501" "55.8" "4.77" "2.75" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00400" "11137" "ENSG00000136045" "PWP1" "A8K3R6; hsa:11137; Q13610; Q7Z3X9" "" "" "0" "0" "0.878" "1.116" "0.922" "0.998" "0.943" "0.969" "0.937" "1.023" "1.047" "184.3" "161.8" "205.6" "170.0" "183.9" "173.7" "178.6" "172.6" "188.6" "193.0" "" "" "" "" "" "" "" "" "" "" "172.7" "133.9" "190.9" "131.4" "156.8" "166.0" "163.2" "153.3" "188.6" "185.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2484461728498550369" "False" "Medium" "IsMasterProtein" "Q5VWN6" "Protein TASOR 2 OS=Homo sapiens OX=9606 GN=TASOR2 PE=1 SV=1" "0.021" "False" "1.809" "0" "1" "1" "1" "2430" "268.7" "5.90" "0.00" "1" "cell organization and biogenesis" "cytosol;nucleus" "" "Pf12480, Pf12509" "54906" "ENSG00000108021" "TASOR2" "hsa:54906; Q2YD91; Q5VWN5; Q5VWN6; Q6ZRQ8; Q8IVG4; Q9BUZ7; Q9H5J9; Q9H7A4; Q9H996; Q9NXA1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3097674846330682720" "False" "Medium" "IsMasterProtein" "O15037" "Protein KHNYN OS=Homo sapiens OX=9606 GN=KHNYN PE=1 SV=3" "0.021" "False" "1.807" "1" "1" "1" "1" "678" "74.5" "7.02" "2.34" "1" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11977" "23351" "ENSG00000100441" "KHNYN" "hsa:23351; O15037; Q86TZ6; Q8IUQ2; Q96BA9" "" "" "0" "0" "1.211" "1.254" "1.116" "1.091" "1.043" "1.109" "1.166" "1.210" "1.188" "68.3" "82.6" "85.6" "76.2" "74.5" "71.2" "75.7" "79.6" "82.6" "81.1" "" "" "" "" "" "" "" "" "" "" "64.0" "68.4" "79.5" "58.9" "63.5" "68.1" "69.2" "70.7" "82.6" "78.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5451664074513337477" "False" "Medium" "IsMasterProtein" "O75629" "Protein CREG1 OS=Homo sapiens OX=9606 GN=CREG1 PE=1 SV=1" "0.021" "False" "1.804" "3" "1" "2" "1" "220" "24.1" "7.59" "4.13" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13883" "8804" "ENSG00000143162" "CREG1" "B2RDD4; hsa:8804; O75629; Q8N9A3" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6403142608945012148" "False" "Medium" "IsMasterProtein" "Q8IX01" "SURP and G-patch domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SUGP2 PE=1 SV=2" "0.021" "False" "1.792" "1" "1" "1" "1" "1082" "120.1" "7.28" "2.31" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf01585, Pf01805" "10147" "ENSG00000064607" "SUGP2" "C9JI71; hsa:10147; O15071; O60369; Q5JPH7; Q8IX01; Q8WUF7" "mRNA processing" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6085773756900444250" "False" "Medium" "IsMasterProtein" "P01706" "Immunoglobulin lambda variable 2-11 OS=Homo sapiens OX=9606 GN=IGLV2-11 PE=1 SV=2" "0.021" "False" "1.791" "7" "1" "1" "1" "119" "12.6" "7.24" "2.74" "1" "other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf07686" "" "ENSG00000211668" "IGLV2-11" "A0A075B6K3; P01706; P01707; P01708; P01712; P01713; P80422" "" "Potential therapeutics for SARS; Initial triggering of complement; Classical antibody-mediated complement activation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Scavenging of heme from plasma; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8587820896620704041" "False" "Medium" "IsMasterProtein" "O15417" "Trinucleotide repeat-containing gene 18 protein OS=Homo sapiens OX=9606 GN=TNRC18 PE=1 SV=3" "0.021" "False" "1.788" "0" "1" "1" "1" "2968" "314.3" "8.70" "2.14" "1" "" "other membranes;cytosol;mitochondrion;nucleus" "other molecular function" "Pf01426, Pf21744" "84629" "ENSG00000182095" "TNRC18" "A8MX41; hsa:84629; O15417; Q96JH1; Q96K91" "" "" "0" "0" "0.908" "0.798" "0.978" "0.940" "0.945" "0.832" "0.732" "0.765" "0.928" "121.0" "109.9" "96.6" "118.3" "113.8" "114.4" "100.7" "88.6" "92.6" "112.3" "" "" "" "" "" "" "" "" "" "" "113.4" "90.9" "89.6" "91.5" "97.0" "109.3" "92.0" "78.6" "92.6" "108.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5456206388273003181" "False" "Medium" "IsMasterProtein" "O95985" "DNA topoisomerase 3-beta-1 OS=Homo sapiens OX=9606 GN=TOP3B PE=1 SV=1" "0.021" "False" "1.787" "1" "1" "1" "1" "862" "96.6" "8.12" "2.28" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01131, Pf01751" "8940" "ENSG00000100038" "TOP3B" "A0M8Q3; hsa:8940; O95985; Q9BUP5" "" "" "0" "0" "1.132" "0.971" "1.094" "1.126" "1.118" "1.490" "1.461" "1.248" "1.152" "52.8" "59.8" "51.2" "57.7" "59.5" "59.0" "78.7" "77.1" "65.9" "60.8" "" "" "" "" "" "" "" "" "" "" "49.5" "49.5" "47.6" "44.6" "50.7" "56.4" "71.9" "68.5" "65.9" "58.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-699160270543076643" "False" "Medium" "IsMasterProtein" "Q14789" "Golgin subfamily B member 1 OS=Homo sapiens OX=9606 GN=GOLGB1 PE=1 SV=2" "0.021" "False" "1.784" "0" "1" "1" "1" "3259" "375.8" "5.00" "2.89" "1" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi" "nucleic acid binding activity" "" "2804" "ENSG00000173230" "GOLGB1" "B2ZZ91; D3DN92; E7EP74; F1T0J2; hsa:2804; Q14398; Q14789" "" "Golgi Associated Vesicle Biogenesis; COPI-mediated anterograde transport; Signaling by FLT3 fusion proteins" "3" "0" "1.146" "1.153" "1.176" "1.189" "1.387" "2.074" "1.682" "1.715" "1.195" "31.5" "36.1" "36.4" "37.1" "37.5" "43.7" "65.4" "53.0" "54.1" "37.7" "" "" "" "" "" "" "" "" "" "" "29.5" "29.9" "33.8" "28.7" "32.0" "41.8" "59.7" "47.1" "54.1" "36.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5823057819559300912" "False" "Medium" "IsMasterProtein" "O15230" "Laminin subunit alpha-5 OS=Homo sapiens OX=9606 GN=LAMA5 PE=1 SV=8" "0.021" "False" "1.781" "0" "1" "1" "1" "3695" "399.5" "7.02" "2.81" "1" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;other cell component" "signal transduction activity or receptor binding" "Pf00052, Pf00053, Pf00054, Pf00055, Pf02210, Pf06008, Pf06009" "3911" "ENSG00000130702" "LAMA5" "hsa:3911; O15230; Q5U4N9; Q8TDF8; Q8WZA7; Q9H1P1" "Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway; Small cell lung cancer; Pleural mesothelioma" "Degradation of the extracellular matrix; ECM proteoglycans; Non-integrin membrane-ECM interactions; Interleukin-4 and Interleukin-13 signaling; Laminin interactions; MET activates PTK2 signaling" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1508097308804950005" "False" "Medium" "IsMasterProtein" "Q9NRP2" "COX assembly mitochondrial protein 2 homolog OS=Homo sapiens OX=9606 GN=CMC2 PE=1 SV=1" "0.021" "False" "1.781" "9" "1" "1" "1" "79" "9.5" "7.87" "2.64" "1" "" "mitochondrion" "" "Pf08583" "56942" "ENSG00000103121; ENSG00000291948" "CMC2" "D3DUK6; hsa:56942; Q9NRP2" "" "Mitochondrial protein import" "1" "0" "1.155" "1.085" "1.152" "1.168" "1.201" "1.079" "1.125" "1.109" "1.136" "146.9" "169.6" "159.3" "169.2" "171.5" "176.4" "158.4" "165.2" "162.8" "166.9" "" "" "" "" "" "" "" "" "" "" "137.6" "140.4" "147.9" "130.8" "146.2" "168.5" "144.8" "146.7" "162.8" "160.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5262953241339830264" "False" "Medium" "IsMasterProtein" "Q8WUH6" "Transmembrane protein 263 OS=Homo sapiens OX=9606 GN=TMEM263 PE=1 SV=1" "0.021" "False" "1.781" "10" "1" "1" "1" "116" "11.7" "9.32" "2.14" "1" "" "other membranes" "" "Pf15475" "90488" "ENSG00000151135" "TMEM263" "B3KMN9; hsa:90488; Q8WUH6" "" "" "0" "0" "1.052" "1.041" "1.101" "1.194" "1.112" "1.229" "1.110" "0.971" "1.056" "47.9" "50.4" "49.8" "52.7" "57.1" "53.2" "58.8" "53.1" "46.5" "50.6" "" "" "" "" "" "" "" "" "" "" "44.8" "41.7" "46.2" "40.7" "48.7" "50.8" "53.7" "47.2" "46.5" "48.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3705334322242747100" "False" "Medium" "IsMasterProtein" "Q12788" "Transducin beta-like protein 3 OS=Homo sapiens OX=9606 GN=TBL3 PE=1 SV=2" "0.021" "False" "1.780" "1" "1" "1" "1" "808" "89.0" "6.90" "2.70" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00400, Pf08625" "10607" "ENSG00000183751; ENSG00000291938" "TBL3" "hsa:10607; Q12788; Q59GD6; Q8IVB7; Q96A78" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-726538263945454181" "False" "Medium" "IsMasterProtein" "Q01459" "Di-N-acetylchitobiase OS=Homo sapiens OX=9606 GN=CTBS PE=1 SV=1" "0.021" "False" "1.779" "2" "1" "1" "1" "385" "43.7" "6.64" "2.31" "1" "other metabolic processes" "other cytoplasmic organelle" "other molecular function" "Pf00704" "1486" "ENSG00000117151" "CTBS" "hsa:1486; Q01459; Q5VX50" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1419370867446709471" "False" "Medium" "IsMasterProtein" "P42677" "Small ribosomal subunit protein eS27 OS=Homo sapiens OX=9606 GN=RPS27 PE=1 SV=3" "0.021" "False" "1.778" "13" "1" "1" "1" "84" "9.5" "9.45" "0.00" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01667" "6232" "ENSG00000177954" "RPS27" "hsa:6232; P42677; Q5T4L6" "Cytoplasmic ribosomal proteins" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "25" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "334815564542611035" "False" "Medium" "IsMasterProtein" "Q9BTF0" "THUMP domain-containing protein 2 OS=Homo sapiens OX=9606 GN=THUMPD2 PE=1 SV=2" "0.021" "False" "1.777" "1" "1" "1" "1" "503" "56.4" "7.81" "2.80" "1" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf01170, Pf02926" "80745" "ENSG00000138050" "THUMPD2" "A8K7I7; hsa:80745; Q53TT8; Q53TV0; Q9BTF0" "" "" "0" "0" "0.997" "1.001" "0.891" "1.053" "1.015" "1.208" "1.121" "1.012" "0.913" "128.9" "128.4" "129.0" "114.8" "135.7" "130.8" "155.6" "144.5" "130.4" "117.7" "" "" "" "" "" "" "" "" "" "" "120.7" "106.3" "119.8" "88.8" "115.7" "125.0" "142.2" "128.3" "130.4" "113.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1011686902353610677" "False" "Medium" "IsMasterProtein" "Q8NBI5" "Equilibrative nucleobase transporter 1 OS=Homo sapiens OX=9606 GN=SLC43A3 PE=1 SV=2" "0.022" "False" "1.777" "2" "1" "1" "1" "491" "54.5" "8.53" "2.36" "1" "transport" "plasma membrane;other membranes" "transporter activity" "" "29015" "ENSG00000134802" "SLC43A3" "B4DNR8; E7EQD2; hsa:29015; Q8NBI5; Q9NSS4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1884033097062610825" "False" "Medium" "IsMasterProtein" "A6NN92" "Putative gap junction epsilon-1 protein OS=Homo sapiens OX=9606 GN=GJE1 PE=5 SV=1" "0.022" "False" "1.769" "4" "1" "2" "1" "205" "23.7" "8.37" "0.00" "1" "cell-cell signaling;transport;developmental processes;other biological processes" "plasma membrane;other membranes" "transporter activity" "Pf00029" "" "ENSG00000203733" "GJE1" "A6NN92" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1443049690155721947" "False" "Medium" "IsMasterProtein" "Q9H0E2" "Toll-interacting protein OS=Homo sapiens OX=9606 GN=TOLLIP PE=1 SV=1" "0.022" "False" "1.766" "3" "1" "1" "1" "274" "30.3" "5.97" "2.90" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00168, Pf02845" "54472" "ENSG00000078902; ENSG00000291426" "TOLLIP" "B3KXC6; hsa:54472; Q9H0E2; Q9H9E6; Q9UJ69" "IL-1 signaling pathway; Interleukin-1 (IL-1) structural pathway; Toll-like receptor signaling related to MyD88; Signal transduction through IL1R; Toll-like receptor signaling pathway" "Neutrophil degranulation; Interleukin-1 signaling" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4446297038364687966" "False" "Medium" "IsMasterProtein" "Q9NPA8" "Transcription and mRNA export factor ENY2 OS=Homo sapiens OX=9606 GN=ENY2 PE=1 SV=1" "0.022" "False" "1.759" "7" "1" "1" "1" "101" "11.5" "9.33" "3.05" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf10163" "56943" "ENSG00000120533" "ENY2" "B2RE52; G3V117; hsa:56943; Q9NPA8" "" "HATs acetylate histones" "1" "0" "1.139" "0.938" "0.913" "1.044" "1.007" "1.035" "1.131" "0.959" "0.926" "197.9" "225.4" "185.6" "180.6" "206.7" "199.2" "204.9" "223.8" "189.9" "183.3" "" "" "" "" "" "" "" "" "" "" "185.4" "186.5" "172.3" "139.6" "176.2" "190.3" "187.2" "198.7" "189.9" "176.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "631101565045639335" "False" "Medium" "IsMasterProtein" "Q8WUU4" "Zinc finger protein 296 OS=Homo sapiens OX=9606 GN=ZNF296 PE=1 SV=1" "0.022" "False" "1.758" "2" "1" "1" "1" "475" "50.8" "8.82" "2.37" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "162979" "ENSG00000170684" "ZNF296" "hsa:162979; Q8WUU4" "" "" "0" "0" "1.036" "1.047" "1.108" "1.005" "1.067" "1.077" "1.051" "1.115" "1.061" "135.4" "140.2" "141.8" "150.0" "136.0" "144.5" "145.9" "142.3" "151.0" "143.7" "" "" "" "" "" "" "" "" "" "" "126.9" "116.1" "131.6" "116.0" "115.9" "138.0" "133.3" "126.3" "151.0" "138.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2659436389650332532" "False" "Medium" "IsMasterProtein" "Q8TEQ0" "Sorting nexin-29 OS=Homo sapiens OX=9606 GN=SNX29 PE=1 SV=3" "0.022" "False" "1.754" "1" "1" "1" "1" "813" "91.2" "6.21" "2.74" "1" "" "" "other molecular function" "Pf00787, Pf02759" "92017" "ENSG00000048471" "SNX29" "B5MDW2; hsa:92017; Q8N2X2; Q8TEQ0; Q9HA26" "" "" "0" "0" "1.002" "0.895" "0.974" "0.932" "0.914" "0.835" "0.854" "0.955" "0.834" "157.2" "157.4" "140.6" "153.0" "146.4" "143.6" "131.3" "134.2" "150.0" "131.1" "" "" "" "" "" "" "" "" "" "" "147.3" "130.3" "130.5" "118.3" "124.8" "137.2" "120.0" "119.2" "150.0" "126.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7431062919970507924" "False" "Medium" "IsMasterProtein" "P62891" "Large ribosomal subunit protein eL39 OS=Homo sapiens OX=9606 GN=RPL39 PE=1 SV=2" "0.023" "False" "1.751" "20" "1" "1" "1" "51" "6.4" "12.56" "2.95" "1" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;cytosol;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00832" "6170" "ENSG00000198918" "RPL39" "hsa:6170; P02404; P39025; P62891; Q9BYF2" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.960" "1.003" "1.111" "1.025" "0.988" "1.086" "1.048" "1.014" "1.055" "114.1" "109.5" "114.4" "126.7" "117.0" "112.7" "123.9" "119.6" "115.7" "120.4" "" "" "" "" "" "" "" "" "" "" "106.9" "90.6" "106.2" "98.0" "99.7" "107.7" "113.2" "106.2" "115.7" "115.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6396845313695786371" "False" "Medium" "IsMasterProtein" "Q8NDX5" "Polyhomeotic-like protein 3 OS=Homo sapiens OX=9606 GN=PHC3 PE=1 SV=1" "0.023" "False" "1.751" "1" "1" "1" "1" "983" "106.1" "6.62" "3.87" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00536, Pf21319" "80012" "ENSG00000173889" "PHC3" "A2RRP9; hsa:80012; Q5HYF0; Q6NSG2; Q8NDX5; Q8NFT7; Q8NFZ1; Q8TBM2; Q9H971; Q9H9I4" "" "SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5483854635859464991" "False" "Medium" "IsMasterProtein" "Q9UKK6" "NTF2-related export protein 1 OS=Homo sapiens OX=9606 GN=NXT1 PE=1 SV=1" "0.023" "False" "1.749" "5" "1" "1" "1" "140" "15.8" "5.03" "2.67" "1" "other metabolic processes;transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf02136" "29107" "ENSG00000132661" "NXT1" "hsa:29107; Q9UKK6" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6273876737902892662" "False" "Medium" "IsMasterProtein" "P83876" "Thioredoxin-like protein 4A OS=Homo sapiens OX=9606 GN=TXNL4A PE=1 SV=1" "0.023" "False" "1.747" "5" "1" "1" "1" "142" "16.8" "5.85" "2.73" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf02966" "10907" "ENSG00000141759" "TXNL4A" "B2RC18; hsa:10907; O14834; P83876" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6806850181049929260" "False" "Medium" "IsMasterProtein" "Q15973" "Zinc finger protein 124 OS=Homo sapiens OX=9606 GN=ZNF124 PE=1 SV=2" "0.023" "False" "1.744" "2" "1" "1" "1" "351" "40.2" "8.82" "1.66" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352, Pf13894" "7678" "ENSG00000196418" "ZNF124" "B3KNP3; hsa:7678; J3KSE1; Q15973; Q15974; Q4VAJ7; Q5T2V4" "" "Generic Transcription Pathway" "1" "0" "0.979" "1.053" "1.021" "1.045" "1.010" "1.015" "1.087" "0.866" "0.943" "201.1" "196.8" "211.8" "205.4" "210.1" "203.2" "204.0" "218.5" "174.1" "189.6" "" "" "" "" "" "" "" "" "" "" "188.4" "162.8" "196.6" "158.8" "179.0" "194.1" "186.4" "194.0" "174.1" "182.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2715206749087144500" "False" "Medium" "IsMasterProtein" "Q8WUR7" "UPF0235 protein C15orf40 OS=Homo sapiens OX=9606 GN=C15orf40 PE=1 SV=2" "0.023" "False" "1.743" "5" "1" "1" "1" "153" "16.3" "9.83" "3.06" "1" "" "other cell component" "" "Pf02594" "123207" "ENSG00000169609" "C15orf40" "A6NIC9; B2R5E7; F5GX92; F8WD31; G5EA00; hsa:123207; Q8WUR7" "15q25 copy number variation" "" "1" "0" "1.045" "1.016" "0.980" "0.980" "1.007" "1.045" "1.072" "0.882" "0.993" "528.5" "552.4" "536.8" "517.8" "517.8" "532.2" "552.0" "566.7" "466.2" "525.0" "" "" "" "" "" "" "" "" "" "" "495.2" "457.1" "498.4" "400.3" "441.3" "508.5" "504.4" "503.2" "466.2" "505.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1595172550313309815" "False" "Medium" "IsMasterProtein" "Q9BY41" "Histone deacetylase 8 OS=Homo sapiens OX=9606 GN=HDAC8 PE=1 SV=2" "0.023" "False" "1.737" "2" "1" "1" "1" "377" "41.7" "5.63" "2.11" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00850" "55869" "ENSG00000147099" "HDAC8" "A6ND12; A6ND61; A6NET3; A6NJR3; A8MQ62; B4DKN0; B4DV22; hsa:55869; Q86VC8; Q9BY41; Q9NP76; Q9NYH4" "Neural crest differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Rett syndrome; Cohesin complex - Cornelia de Lange syndrome" "HDACs deacetylate histones; NOTCH1 Intracellular Domain Regulates Transcription; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Notch-HLH transcription pathway" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6547386205505404973" "False" "Medium" "IsMasterProtein" "Q9NWW7" "Uncharacterized protein C2orf42 OS=Homo sapiens OX=9606 GN=C2orf42 PE=1 SV=1" "0.023" "False" "1.735" "1" "1" "1" "1" "574" "64.0" "8.92" "2.65" "1" "" "nucleus" "" "Pf14952" "54980" "ENSG00000115998" "C2orf42" "D6W5G3; Q9H629; Q9NWW7" "" "" "0" "0" "0.809" "1.046" "0.899" "0.946" "0.814" "0.912" "0.913" "0.839" "0.896" "367.8" "297.7" "384.7" "330.6" "348.0" "299.5" "335.5" "335.9" "308.6" "329.6" "" "" "" "" "" "" "" "" "" "" "344.6" "246.4" "357.1" "255.6" "296.6" "286.2" "306.6" "298.2" "308.6" "317.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2021793089049175464" "False" "Medium" "IsMasterProtein" "Q9HD67" "Unconventional myosin-X OS=Homo sapiens OX=9606 GN=MYO10 PE=1 SV=3" "0.023" "False" "1.730" "0" "1" "1" "1" "2058" "237.2" "6.21" "2.58" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf00169, Pf00373, Pf00612, Pf00784, Pf00788, Pf16735, Pf18597" "4651" "ENSG00000145555" "MYO10" "A7E2D1; hsa:4651; O94893; Q8IVX5; Q9HD67; Q9NYM7; Q9P110; Q9P111; Q9UHF6" "" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Netrin-1 signaling" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4653603657253563798" "False" "Medium" "IsMasterProtein" "Q7Z7H5" "Transmembrane emp24 domain-containing protein 4 OS=Homo sapiens OX=9606 GN=TMED4 PE=1 SV=1" "0.023" "False" "1.729" "3" "1" "1" "1" "227" "25.9" "8.28" "2.90" "1" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cell component" "" "Pf01105" "222068" "ENSG00000158604" "TMED4" "A4D2K8; B4DFJ4; hsa:222068; Q56VW3; Q7Z432; Q7Z7H5; Q8N2P6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4731047404195791293" "False" "Medium" "IsMasterProtein" "Q8IXW5" "Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 OS=Homo sapiens OX=9606 GN=RPAP2 PE=1 SV=1" "0.023" "False" "1.728" "2" "1" "1" "1" "612" "69.5" "7.78" "0.00" "1" "RNA metabolism OR transcription;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04181" "79871" "ENSG00000122484" "RPAP2" "C9JKB5; hsa:79871; Q49AS7; Q8IXW5; Q9H8Y2" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6623935666392123134" "False" "Medium" "IsMasterProtein" "Q8N653" "Leucine-zipper-like transcriptional regulator 1 OS=Homo sapiens OX=9606 GN=LZTR1 PE=1 SV=2" "0.023" "False" "1.728" "1" "1" "1" "1" "840" "94.7" "6.57" "2.38" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00651, Pf01344, Pf13415, Pf13418" "8216" "ENSG00000099949" "LZTR1" "hsa:8216; Q14776; Q20WK0; Q8N653" "22q11.2 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2905303877157199956" "False" "Medium" "IsMasterProtein" "Q10469" "Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase OS=Homo sapiens OX=9606 GN=MGAT2 PE=1 SV=1" "0.023" "False" "1.726" "2" "1" "1" "1" "447" "51.5" "8.76" "2.43" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf05060" "4247" "ENSG00000168282" "MGAT2" "B3KPC5; B3KQM0; hsa:4247; Q10469" "N-glycan biosynthesis" "Reactions specific to the complex N-glycan synthesis pathway; Maturation of spike protein; Defective MGAT2 causes CDG-2a" "4" "0" "1.155" "1.044" "1.321" "1.035" "1.003" "1.409" "1.216" "1.186" "1.211" "110.1" "127.1" "114.9" "145.4" "114.0" "110.4" "155.1" "133.8" "130.5" "133.3" "" "" "" "" "" "" "" "" "" "" "103.1" "105.2" "106.7" "112.4" "97.1" "105.4" "141.7" "118.8" "130.5" "128.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1550632578398820844" "False" "Medium" "IsMasterProtein" "Q8N3P4" "Vacuolar protein sorting-associated protein 8 homolog OS=Homo sapiens OX=9606 GN=VPS8 PE=1 SV=3" "0.023" "False" "1.725" "1" "1" "1" "1" "1428" "161.7" "5.64" "0.00" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf12816" "23355" "ENSG00000156931" "VPS8" "A8K8Q8; B9EIQ1; C9JB61; hsa:23355; O94896; Q63HP2; Q8N3P4; Q9BVP9; Q9H9B0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8284852689861497980" "False" "Medium" "IsMasterProtein" "Q5VV52" "Zinc finger protein 691 OS=Homo sapiens OX=9606 GN=ZNF691 PE=1 SV=2" "0.023" "False" "1.724" "3" "1" "1" "1" "315" "35.8" "7.80" "2.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13465" "51058" "ENSG00000164011" "ZNF691" "A8MXP6; B4DJR7; hsa:51058; O95878; Q5VV52; Q9NWE8" "" "Generic Transcription Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2434298641534178381" "False" "Medium" "IsMasterProtein" "P42336" "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform OS=Homo sapiens OX=9606 GN=PIK3CA PE=1 SV=2" "0.023" "False" "1.720" "1" "1" "1" "1" "1068" "124.2" "7.23" "0.00" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792, Pf00794, Pf02192" "5290" "ENSG00000121879" "PIK3CA" "hsa:5290; P42336; Q14CW1; Q99762" "AMP-activated protein kinase signaling; Angiogenesis; MicroRNAs in cardiomyocyte hypertrophy; Sterol regulatory element-binding proteins (SREBP) signaling; Thyroid stimulating hormone (TSH) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; IL1 and megakaryocytes in obesity; Transcriptional activation by NRF2 in response to phytochemicals; Focal adhesion; Hepatocyte growth factor receptor signaling; Copper homeostasis; RAC1/PAK1/p38/MMP2 pathway; Pathways affected in adenoid cystic carcinoma; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; Fibrin complement receptor 3 signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; NRF2-ARE regulation; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Overview of interferons-mediated signaling pathway; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Regucalcin in proximal tubule epithelial kidney cells; Kisspeptin/kisspeptin receptor system in the ovary; Kallmann syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; Congenital generalized lipodystrophy; Familial partial lipodystrophy; Alzheimer's disease; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Warburg effect modulated by deubiquitinating enzymes and their substrates; G13 signaling pathway; Comprehensive IL-17A signaling; Acute myeloid leukemia; IL-26 signaling pathways; Osteoarthritic chondrocyte hypertrophy; GNAQ pathways in port-wine stain; ErbB signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Toll-like receptor signaling pathway" "Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Downstream TCR signaling; RAC1 GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; Signaling by ALK fusions and activated point mutants; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; RAF/MAP kinase cascade; PI3K Cascade; GPVI-mediated activation cascade; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; PI3K events in ERBB4 signaling; PI3K events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; GAB1 signalosome; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by CSF1 (M-CSF) in myeloid cells; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; Signaling by FGFR2 in disease; PI-3K cascade:FGFR3; PI-3K cascade:FGFR4; Signaling by FGFR3 in disease; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; MET activates PI3K/AKT signaling; Activated NTRK3 signals through PI3K; Activated NTRK2 signals through PI3K" "140" "0" "0.938" "1.124" "0.884" "0.968" "1.123" "0.891" "1.152" "1.163" "1.118" "170.0" "159.4" "191.1" "150.2" "164.6" "191.0" "151.5" "196.0" "197.8" "190.1" "" "" "" "" "" "" "" "" "" "" "159.3" "131.9" "177.4" "116.1" "140.3" "182.5" "138.4" "174.0" "197.8" "183.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6381027269296732412" "False" "Medium" "IsMasterProtein" "Q7Z392" "Trafficking protein particle complex subunit 11 OS=Homo sapiens OX=9606 GN=TRAPPC11 PE=1 SV=2" "0.023" "False" "1.719" "1" "1" "1" "1" "1133" "128.8" "7.14" "2.53" "1" "cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;other cell component" "" "Pf11817, Pf12742" "60684" "ENSG00000168538" "TRAPPC11" "A4QPB8; B2RCD6; hsa:60684; Q5U5I7; Q6FI73; Q7Z392; Q86T25; Q9H0L1; Q9H5K9; Q9H8Q1; Q9H9I7" "Genes related to primary cilium development (based on CRISPR)" "RAB GEFs exchange GTP for GDP on RABs" "2" "0" "1.040" "1.049" "1.058" "0.994" "1.018" "1.028" "1.067" "0.981" "1.016" "83.2" "86.6" "87.3" "88.0" "82.7" "84.8" "85.6" "88.8" "81.6" "84.5" "" "" "" "" "" "" "" "" "" "" "78.0" "71.6" "81.1" "68.1" "70.5" "81.0" "78.2" "78.9" "81.6" "81.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5710815529521285644" "False" "Medium" "IsMasterProtein" "Q9BQ70" "Ribosome quality control complex subunit TCF25 OS=Homo sapiens OX=9606 GN=TCF25 PE=1 SV=1" "0.023" "False" "1.717" "2" "1" "1" "1" "676" "76.6" "6.35" "2.48" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04910" "22980" "ENSG00000141002" "TCF25" "hsa:22980; Q2MK75; Q9BQ70; Q9UPV3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516422207583123109" "False" "Medium" "IsMasterProtein" "Q9NUD5" "Zinc finger CCHC domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZCCHC3 PE=1 SV=2" "0.023" "False" "1.717" "2" "1" "1" "1" "403" "43.5" "8.53" "2.26" "1" "stress response;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00098" "85364" "ENSG00000247315" "ZCCHC3" "hsa:85364; Q3B7J3; Q6NT79; Q9NUD5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6297313033402222307" "False" "Medium" "IsMasterProtein" "Q8TF01" "Arginine/serine-rich protein PNISR OS=Homo sapiens OX=9606 GN=PNISR PE=1 SV=2" "0.023" "False" "1.716" "1" "1" "1" "1" "805" "92.5" "10.02" "2.74" "1" "" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf15996" "25957" "ENSG00000132424" "PNISR" "A8K540; E1P5D2; hsa:25957; Q5T064; Q5T065; Q6P2B4; Q6P2N4; Q6PJ93; Q6PK36; Q7Z640; Q8N2L1; Q8TF00; Q8TF01; Q96K10; Q96SI3; Q96SM5; Q9P076; Q9P0C0; Q9Y4N3" "" "" "0" "0" "1.430" "1.072" "1.644" "1.224" "1.064" "1.717" "1.401" "1.368" "1.209" "84.7" "121.1" "90.8" "139.3" "103.7" "90.2" "145.4" "118.7" "115.9" "102.4" "" "" "" "" "" "" "" "" "" "" "79.4" "100.2" "84.3" "107.7" "88.4" "86.2" "132.9" "105.4" "115.9" "98.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8104731299280243918" "False" "Medium" "IsMasterProtein" "Q4G148" "Glucoside xylosyltransferase 1 OS=Homo sapiens OX=9606 GN=GXYLT1 PE=1 SV=2" "0.023" "False" "1.714" "2" "1" "1" "1" "440" "50.5" "8.65" "2.37" "1" "protein metabolism;other metabolic processes" "other membranes" "other molecular function" "Pf01501" "283464" "ENSG00000151233" "GXYLT1" "B3KWJ2; hsa:283464; Q4G148; Q8IXV1; Q96BH4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2535135395164112803" "False" "Medium" "IsMasterProtein" "Q96KM6" "Zinc finger protein 512B OS=Homo sapiens OX=9606 GN=ZNF512B PE=1 SV=1" "0.024" "False" "1.712" "1" "1" "1" "1" "892" "97.2" "9.83" "2.57" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf21276" "57473" "ENSG00000196700" "ZNF512B" "hsa:57473; Q08AK9; Q96KM6; Q9ULM4" "" "RHOV GTPase cycle" "1" "0" "1.031" "1.053" "1.159" "1.232" "1.104" "1.461" "1.422" "1.235" "1.109" "94.9" "97.9" "100.0" "110.0" "116.9" "104.8" "138.7" "135.0" "117.2" "105.3" "" "" "" "" "" "" "" "" "" "" "88.9" "81.0" "92.8" "85.0" "99.7" "100.1" "126.7" "119.9" "117.2" "101.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6516926494884828082" "False" "Medium" "IsMasterProtein" "Q7RTR2" "NLR family CARD domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NLRC3 PE=1 SV=2" "0.024" "False" "1.708" "1" "1" "1" "1" "1065" "114.6" "8.29" "2.03" "1" "signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf05729, Pf13516, Pf17776, Pf17779" "197358" "ENSG00000167984" "NLRC3" "hsa:197358; Q5EY36; Q7RTR2; Q8NF48; Q8NI01; Q8NI02; Q8TEL3" "" "IRF3-mediated induction of type I IFN" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1927302242065812725" "False" "Medium" "IsMasterProtein" "P43234" "Cathepsin O OS=Homo sapiens OX=9606 GN=CTSO PE=1 SV=1" "0.024" "False" "1.704" "2" "1" "1" "1" "321" "35.9" "7.42" "2.41" "1" "protein metabolism;other metabolic processes" "non-structural extracellular;other cytoplasmic organelle" "other molecular function" "Pf00112" "1519" "ENSG00000256043; ENSG00000263238" "CTSO" "hsa:1519; P43234" "" "MHC class II antigen presentation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2296916383652884843" "False" "Medium" "IsMasterProtein" "P13497" "Bone morphogenetic protein 1 OS=Homo sapiens OX=9606 GN=BMP1 PE=1 SV=2" "0.024" "False" "1.703" "1" "1" "1" "1" "986" "111.2" "6.90" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00431, Pf01400, Pf07645, Pf14670" "649" "ENSG00000168487" "BMP1" "A8K6F5; B2RN46; D3DSR0; hsa:649; P13497; Q13292; Q13872; Q14874; Q99421; Q99422; Q99423; Q9UL38" "Adipogenesis; Cardiac progenitor differentiation; Canonical and non-canonical TGF-B signaling; EDA signaling in hair follicle development; Type I collagen synthesis in the context of osteogenesis imperfecta; 8p23.1 copy number variation syndrome" "Degradation of the extracellular matrix; Collagen biosynthesis and modifying enzymes; Anchoring fibril formation; Crosslinking of collagen fibrils" "10" "0" "0.848" "1.171" "0.953" "0.909" "0.959" "1.078" "0.926" "0.944" "0.910" "31.8" "26.9" "37.2" "30.3" "28.9" "30.5" "34.2" "29.4" "30.0" "28.9" "" "" "" "" "" "" "" "" "" "" "29.8" "22.3" "34.5" "23.4" "24.6" "29.1" "31.3" "26.1" "30.0" "27.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6977987857049713242" "False" "Medium" "IsMasterProtein" "Q14159" "DNA repair-scaffolding protein OS=Homo sapiens OX=9606 GN=SPIDR PE=1 SV=2" "0.024" "False" "1.700" "1" "1" "1" "1" "915" "100.3" "6.62" "2.49" "1" "DNA metabolism;stress response;other biological processes" "nucleus" "" "Pf14950, Pf14951" "23514" "ENSG00000164808" "SPIDR" "B4DFV2; B4E0Y6; hsa:23514; Q14159; Q96BI5" "Primary ovarian insufficiency" "Resolution of D-loop Structures through Holliday Junction Intermediates" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "660513057168003161" "False" "Medium" "IsMasterProtein" "Q99805" "Transmembrane 9 superfamily member 2 OS=Homo sapiens OX=9606 GN=TM9SF2 PE=1 SV=1" "0.024" "False" "1.698" "1" "1" "1" "1" "663" "75.7" "7.44" "0.00" "1" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle" "" "Pf02990" "9375" "ENSG00000125304" "TM9SF2" "A8K399; hsa:9375; Q2TAY5; Q99805" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1791941812365696393" "False" "Medium" "IsMasterProtein" "Q8WWF8" "Calcyphosin-like protein OS=Homo sapiens OX=9606 GN=CAPSL PE=1 SV=4" "0.024" "False" "1.697" "4" "1" "2" "1" "208" "24.2" "6.05" "4.97" "1" "" "other cell component" "other molecular function" "Pf13499" "133690" "ENSG00000152611" "CAPSL" "hsa:133690; Q8WWF8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5766745797864106974" "False" "Medium" "IsMasterProtein" "O75528" "Transcriptional adapter 3 OS=Homo sapiens OX=9606 GN=TADA3 PE=1 SV=1" "0.024" "False" "1.695" "2" "1" "1" "1" "432" "48.9" "6.27" "3.29" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10198" "10474" "ENSG00000171148" "TADA3" "hsa:10474; O75528; Q6FI83; Q9UFS2" "" "Ub-specific processing proteases; Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "3" "0" "0.964" "0.972" "0.957" "1.053" "1.040" "0.989" "1.055" "1.017" "1.038" "361.0" "347.9" "350.7" "345.5" "380.2" "375.4" "357.0" "381.0" "367.1" "374.6" "" "" "" "" "" "" "" "" "" "" "338.2" "287.9" "325.6" "267.1" "324.0" "358.7" "326.2" "338.2" "367.1" "360.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1066675422461662542" "False" "Medium" "IsMasterProtein" "Q8WVE0" "EEF1A lysine methyltransferase 1 OS=Homo sapiens OX=9606 GN=EEF1AKMT1 PE=1 SV=1" "0.024" "False" "1.694" "3" "1" "1" "1" "214" "24.5" "4.55" "2.60" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf10237" "221143" "ENSG00000150456" "EEF1AKMT1" "B5G4V1; hsa:221143; Q8WVE0" "" "Protein methylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-357583033537535039" "False" "Medium" "IsMasterProtein" "Q9NX20" "Large ribosomal subunit protein uL16m OS=Homo sapiens OX=9606 GN=MRPL16 PE=1 SV=1" "0.024" "False" "1.693" "4" "1" "1" "1" "251" "28.4" "10.13" "3.47" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00252" "54948" "ENSG00000166902" "MRPL16" "hsa:54948; Q9BYD0; Q9HB70; Q9NX20" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6639603316967451173" "False" "Medium" "IsMasterProtein" "Q5TC84" "Opioid growth factor receptor-like protein 1 OS=Homo sapiens OX=9606 GN=OGFRL1 PE=1 SV=1" "0.024" "False" "1.693" "2" "1" "1" "1" "451" "51.2" "6.13" "2.97" "1" "" "other membranes" "other molecular function" "Pf04664" "79627" "ENSG00000119900" "OGFRL1" "hsa:79627; Q2TAC1; Q5TC84; Q8NEQ4; Q9H7B5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3073317532419455068" "False" "Medium" "IsMasterProtein" "Q07954" "Prolow-density lipoprotein receptor-related protein 1 OS=Homo sapiens OX=9606 GN=LRP1 PE=1 SV=2" "0.024" "False" "1.688" "0" "1" "1" "1" "4544" "504.3" "5.39" "2.98" "1" "other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00057, Pf00058, Pf07645, Pf12662, Pf14670, Pf16472" "4035" "ENSG00000123384" "LRP1" "hsa:4035; Q07954; Q2PP12; Q86SW0; Q8IVG8" "Alzheimer's disease and miRNA effects; Regulation of Wnt / B-catenin signaling by small molecule compounds; Statin inhibition of cholesterol production; Familial hyperlipidemia type 1; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; Alzheimer's disease; Cholesterol metabolism" "Scavenging of heme from plasma; Retinoid metabolism and transport" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-591472861565876491" "False" "Medium" "IsMasterProtein" "Q6V9R5" "Zinc finger protein 562 OS=Homo sapiens OX=9606 GN=ZNF562 PE=1 SV=2" "0.024" "False" "1.686" "2" "1" "1" "1" "426" "48.5" "8.41" "1.79" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "54811" "ENSG00000171466" "ZNF562" "hsa:54811; Q32MN2; Q6V9R5; Q9NXS5" "" "Generic Transcription Pathway" "1" "0" "0.985" "0.888" "1.055" "0.929" "0.891" "1.031" "0.965" "0.864" "0.879" "247.9" "244.1" "220.1" "261.6" "230.3" "221.0" "255.5" "239.3" "214.3" "217.9" "" "" "" "" "" "" "" "" "" "" "232.3" "202.0" "204.3" "202.2" "196.3" "211.1" "233.5" "212.5" "214.3" "209.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3286506536231380161" "False" "Medium" "IsMasterProtein" "Q9NZI7" "Upstream-binding protein 1 OS=Homo sapiens OX=9606 GN=UBP1 PE=1 SV=1" "0.024" "False" "1.686" "1" "1" "1" "1" "540" "60.5" "6.35" "2.93" "1" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04516, Pf18016" "7342" "ENSG00000153560" "UBP1" "hsa:7342; Q68CT0; Q86Y57; Q9H8V0; Q9NZI7; Q9UD76; Q9UD78" "" "" "0" "0" "1.021" "1.000" "1.155" "1.148" "1.079" "1.111" "0.968" "1.074" "1.085" "266.2" "271.9" "266.3" "307.5" "305.7" "287.3" "295.8" "257.7" "286.0" "288.9" "" "" "" "" "" "" "" "" "" "" "249.5" "225.0" "247.2" "237.7" "260.6" "274.5" "270.3" "228.8" "286.0" "278.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1090044883093451685" "False" "Medium" "IsMasterProtein" "Q6PGQ7" "Protein aurora borealis OS=Homo sapiens OX=9606 GN=BORA PE=1 SV=2" "0.024" "False" "1.685" "2" "1" "1" "1" "559" "61.2" "4.94" "2.23" "1" "cell cycle OR cell proliferation;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15280" "79866" "ENSG00000136122" "BORA" "B4DQ30; hsa:79866; Q5W0P3; Q5W0P4; Q6PGQ7; Q86YC6; Q96IW9; Q9H640" "" "Regulation of PLK1 Activity at G2/M Transition" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "-6035994145321959470" "False" "Medium" "IsMasterProtein" "Q8NE63" "Homeodomain-interacting protein kinase 4 OS=Homo sapiens OX=9606 GN=HIPK4 PE=1 SV=1" "0.024" "False" "1.679" "1" "1" "1" "1" "616" "69.4" "6.65" "2.88" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "147746" "ENSG00000160396" "HIPK4" "A8K863; hsa:147746; Q8NE63; Q96M54" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1307964250316043321" "False" "Medium" "IsMasterProtein" "Q9H9E1" "Ankyrin repeat family A protein 2 OS=Homo sapiens OX=9606 GN=ANKRA2 PE=1 SV=1" "0.024" "False" "1.679" "2" "1" "1" "1" "313" "34.3" "5.11" "2.28" "1" "other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00023, Pf12796" "57763" "ENSG00000164331" "ANKRA2" "hsa:57763; Q9H9E1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7663902288491648991" "False" "Medium" "IsMasterProtein" "Q96BD5" "PHD finger protein 21A OS=Homo sapiens OX=9606 GN=PHF21A PE=1 SV=1" "0.024" "False" "1.679" "1" "1" "1" "1" "680" "74.8" "9.45" "0.00" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00628" "51317" "ENSG00000135365" "PHF21A" "D3DQP5; hsa:51317; Q6AWA2; Q96BD5; Q9C0G7; Q9H8V9; Q9HAK6; Q9NZE9" "11p11.2 copy number variation syndrome" "HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; Potential therapeutics for SARS" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7200056701513102621" "False" "Medium" "IsMasterProtein" "P12236" "ADP/ATP translocase 3 OS=Homo sapiens OX=9606 GN=SLC25A6 PE=1 SV=4" "0.024" "False" "1.676" "3" "1" "1" "1" "298" "32.8" "9.74" "3.09" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf00153" "293" "ENSG00000169100; ENSG00000292334" "SLC25A6" "hsa:293; P12236; Q96C49" "Electron transport chain: OXPHOS system in mitochondria; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Mitochondrial protein degradation; Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Mitochondrial protein import; Influenza Virus Induced Apoptosis; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1220835464658620030" "False" "Medium" "IsMasterProtein" "Q7L2E3" "ATP-dependent RNA helicase DHX30 OS=Homo sapiens OX=9606 GN=DHX30 PE=1 SV=1" "0.025" "False" "1.673" "1" "1" "1" "1" "1194" "133.9" "8.78" "1.95" "1" "cell organization and biogenesis;developmental processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf07717, Pf21010" "22907" "ENSG00000132153" "DHX30" "A8K5F1; hsa:22907; O94965; Q7L2E3; Q7Z753; Q96CH4; Q9NUQ0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3882747240626213666" "False" "Medium" "IsMasterProtein" "Q5QJ38" "Trichohyalin-like protein 1 OS=Homo sapiens OX=9606 GN=TCHHL1 PE=1 SV=1" "0.025" "False" "1.673" "1" "1" "1" "1" "904" "99.2" "4.69" "0.00" "1" "" "" "other molecular function" "Pf01023" "126637" "ENSG00000182898" "TCHHL1" "B2RPK8; hsa:126637; Q5QJ38; Q5VTJ9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5682708394690441671" "False" "Medium" "IsMasterProtein" "A8MPS7" "Carbohydrate deacetylase OS=Homo sapiens OX=9606 GN=YDJC PE=1 SV=1" "0.025" "False" "1.665" "2" "1" "1" "1" "323" "34.4" "6.39" "3.09" "1" "other metabolic processes" "" "other molecular function" "Pf04794" "150223" "ENSG00000161179" "YDJC" "A8MPS7; hsa:150223; Q2YDT4; Q4V9R7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7331601319371966852" "False" "Medium" "IsMasterProtein" "P21964" "Catechol O-methyltransferase OS=Homo sapiens OX=9606 GN=COMT PE=1 SV=2" "0.025" "False" "1.664" "3" "1" "1" "1" "271" "30.0" "5.47" "2.70" "1" "cell-cell signaling;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01596" "1312" "ENSG00000093010" "COMT" "A8MPV9; hsa:1312; P21964; Q6IB07; Q6ICE6; Q9BWC7" "Dopamine metabolism; Flavan-3-ol metabolic pathway; MTHFR deficiency; 22q11.2 copy number variation syndrome; Primary ovarian insufficiency; Biogenic amine synthesis; Estrogen metabolism; Metapathway biotransformation Phase I and II; Methylation pathways" "Potential therapeutics for SARS; Methylation; Enzymatic degradation of dopamine by COMT; Enzymatic degradation of Dopamine by monoamine oxidase" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6724836998549687317" "False" "Medium" "IsMasterProtein" "Q9Y6F9" "Protein Wnt-6 OS=Homo sapiens OX=9606 GN=WNT6 PE=1 SV=2" "0.025" "False" "1.664" "2" "1" "1" "1" "365" "39.7" "8.79" "1.86" "1" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component" "signal transduction activity or receptor binding" "Pf00110" "7475" "ENSG00000115596" "WNT6" "hsa:7475; Q9H1J6; Q9H238; Q9Y6F9" "Alzheimer's disease and miRNA effects; lncRNA-mediated mechanisms of therapeutic resistance; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)" "Class B/2 (Secretin family receptors); WNT ligand biogenesis and trafficking" "16" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6133678444779992417" "False" "Medium" "IsMasterProtein" "Q9UGU0" "Transcription factor 20 OS=Homo sapiens OX=9606 GN=TCF20 PE=1 SV=3" "0.025" "False" "1.661" "0" "1" "1" "1" "1960" "211.6" "9.04" "2.09" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13771" "6942" "ENSG00000100207; ENSG00000262024; ENSG00000276461" "TCF20" "A9JX12; hsa:6942; O14528; Q13078; Q4V353; Q9H4M0; Q9UGU0" "Matrix metalloproteinases" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7159036767897580858" "False" "Medium" "IsMasterProtein" "P20036" "HLA class II histocompatibility antigen, DP alpha 1 chain OS=Homo sapiens OX=9606 GN=HLA-DPA1 PE=1 SV=1" "0.025" "False" "1.661" "3" "1" "2" "1" "260" "29.4" "5.21" "2.36" "1" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00993, Pf07654" "3113" "ENSG00000168384; ENSG00000206291; ENSG00000224103; ENSG00000228163; ENSG00000229685; ENSG00000231389; ENSG00000235844; ENSG00000236177" "HLA-DPA1" "A9YWH7; B9UKH4; O19722; O46883; P01905; P20036; P79554; Q2Q060; Q2Q061; Q5EY03; Q5STP1; Q6DQK4; Q9BCQ1; Q9TPX3; Q9XS10" "Allograft rejection; Ebola virus infection in host" "Interferon gamma signaling; Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8866884137878519266" "False" "Medium" "IsMasterProtein" "Q6ZVW7" "Interleukin-17 receptor E-like protein OS=Homo sapiens OX=9606 GN=IL17REL PE=1 SV=3" "0.025" "False" "1.658" "2" "1" "1" "1" "507" "56.5" "8.84" "0.00" "1" "signal transduction" "" "other molecular function" "Pf15037" "400935" "ENSG00000188263" "IL17REL" "A0A8Q3WKV1; A6NCN4; A6PVC1; hsa:400935; Q6ZVW7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9000189900637042825" "False" "Medium" "IsMasterProtein" "Q6JQN1" "Acyl-CoA dehydrogenase family member 10 OS=Homo sapiens OX=9606 GN=ACAD10 PE=1 SV=1" "0.026" "False" "1.655" "1" "1" "1" "1" "1059" "118.8" "8.06" "2.53" "1" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00441, Pf00702, Pf01636, Pf02770, Pf02771" "80724" "ENSG00000111271" "ACAD10" "G3XAJ0; hsa:80724; Q6JQN1; Q8N828; Q8NAP2; Q96BX5" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "0.944" "1.110" "1.174" "1.228" "1.080" "1.197" "1.124" "1.079" "1.239" "147.7" "139.4" "163.8" "173.4" "181.3" "159.5" "176.7" "166.0" "159.4" "183.0" "" "" "" "" "" "" "" "" "" "" "138.4" "115.3" "152.1" "134.1" "154.5" "152.4" "161.4" "147.4" "159.4" "176.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7135249905505884321" "False" "Medium" "IsMasterProtein" "P0DTL6" "Zinc finger TRAF-type-containing protein 1 OS=Homo sapiens OX=9606 GN=ZFTRAF1 PE=1 SV=1" "0.026" "False" "1.655" "2" "1" "1" "1" "404" "43.8" "6.76" "2.41" "1" "" "nucleus;other cell component" "other molecular function" "" "157542; 50626; 84773" "ENSG00000187954" "ZFTRAF1" "B3KSX0; D3DWM3; E9PJD7; hsa:157542; hsa:50626; hsa:84773; P0DTL6; Q6ZMK1; Q9BSF6; Q9BSU6" "" "" "0" "0" "0.990" "0.949" "1.059" "1.044" "0.961" "1.044" "0.974" "0.994" "1.048" "315.4" "312.1" "299.4" "334.1" "329.4" "303.3" "329.2" "307.2" "313.4" "330.5" "" "" "" "" "" "" "" "" "" "" "295.5" "258.3" "278.0" "258.3" "280.8" "289.7" "300.8" "272.8" "313.4" "318.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-728003267780759381" "False" "Medium" "IsMasterProtein" "Q8WV07" "Protein LTO1 homolog OS=Homo sapiens OX=9606 GN=LTO1 PE=1 SV=2" "0.026" "False" "1.654" "5" "1" "1" "1" "137" "15.3" "5.80" "2.27" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus" "" "Pf09811" "220064" "ENSG00000149716" "LTO1" "B2R4R2; hsa:220064; Q8NFK0; Q8WV07" "" "" "0" "0" "1.083" "0.974" "0.877" "0.994" "1.001" "0.934" "0.988" "1.069" "1.012" "203.0" "219.8" "197.8" "178.0" "201.8" "203.2" "189.5" "200.6" "217.0" "205.4" "" "" "" "" "" "" "" "" "" "" "190.2" "181.9" "183.6" "137.6" "172.0" "194.2" "173.2" "178.1" "217.0" "197.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4717651617297181896" "False" "Medium" "IsMasterProtein" "Q9UIC8" "Leucine carboxyl methyltransferase 1 OS=Homo sapiens OX=9606 GN=LCMT1 PE=1 SV=2" "0.026" "False" "1.652" "3" "1" "1" "1" "334" "38.4" "6.04" "3.06" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04072" "51451" "ENSG00000205629" "LCMT1" "A6NL89; A8K770; hsa:51451; Q53FC5; Q96CI5; Q9H6I9; Q9NTG4; Q9UIC8; Q9Y378" "" "Cyclin A/B1/B2 associated events during G2/M transition" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8583026759934693939" "False" "Medium" "IsMasterProtein" "Q9P1Z2" "Calcium-binding and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CALCOCO1 PE=1 SV=2" "0.026" "False" "1.650" "1" "1" "1" "1" "691" "77.3" "4.82" "2.67" "1" "cell-cell signaling;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07888, Pf17751, Pf18112" "57658" "ENSG00000012822" "CALCOCO1" "B3KVA8; hsa:57658; Q6FI59; Q71RC3; Q86WF8; Q96JU3; Q9H090; Q9P1Z2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8448471456180421378" "False" "Medium" "IsMasterProtein" "Q9P275" "Ubiquitin carboxyl-terminal hydrolase 36 OS=Homo sapiens OX=9606 GN=USP36 PE=1 SV=4" "0.027" "False" "1.648" "1" "1" "1" "1" "1123" "122.8" "9.70" "2.51" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443" "57602" "ENSG00000055483" "USP36" "hsa:57602; Q05C98; Q05DD0; Q6IQ38; Q8NDM8; Q9NVC8; Q9P275" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6300467232994524401" "False" "Medium" "IsMasterProtein" "Q8NBX0" "Saccharopine dehydrogenase-like oxidoreductase OS=Homo sapiens OX=9606 GN=SCCPDH PE=1 SV=1" "0.027" "False" "1.644" "2" "1" "1" "1" "429" "47.1" "9.14" "3.14" "1" "other metabolic processes" "non-structural extracellular;other cell component" "other molecular function" "Pf03435" "51097" "ENSG00000143653" "SCCPDH" "hsa:51097; Q8NBX0; Q8TAR0; Q9Y363" "" "Platelet degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9119183533352449248" "False" "Medium" "IsMasterProtein" "Q9P0P8" "Mitochondrial transcription rescue factor 1 OS=Homo sapiens OX=9606 GN=MTRES1 PE=1 SV=1" "0.027" "False" "1.643" "3" "1" "1" "1" "240" "27.9" "9.29" "2.26" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "translation activity;nucleic acid binding activity" "" "51250" "ENSG00000130349" "MTRES1" "B3KRG9; hsa:51250; Q9P0P8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "836447758182976834" "False" "Medium" "IsMasterProtein" "Q6P2D0" "Zinc finger protein 1 homolog OS=Homo sapiens OX=9606 GN=ZFP1 PE=1 SV=2" "0.027" "False" "1.641" "2" "1" "1" "1" "407" "47.5" "8.57" "2.36" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "162239" "ENSG00000184517" "ZFP1" "A8K5Q7; B4DKG9; hsa:162239; Q6P2D0; Q8N188; Q8N9F9" "" "Generic Transcription Pathway" "1" "0" "0.924" "0.764" "0.954" "0.968" "0.854" "0.871" "0.784" "0.871" "0.889" "74.5" "68.8" "56.9" "71.1" "72.1" "63.6" "64.9" "58.4" "64.9" "66.2" "" "" "" "" "" "" "" "" "" "" "69.8" "57.0" "52.8" "54.9" "61.5" "60.8" "59.3" "51.8" "64.9" "63.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "531745898464633118" "False" "Medium" "IsMasterProtein" "Q6P3S6" "F-box only protein 42 OS=Homo sapiens OX=9606 GN=FBXO42 PE=1 SV=1" "0.027" "False" "1.640" "1" "1" "1" "1" "717" "77.8" "7.43" "2.52" "1" "" "other cell component" "other molecular function" "Pf12937, Pf13415, Pf13854" "54455" "ENSG00000037637; ENSG00000291375" "FBXO42" "B3KP30; hsa:54455; Q5TEU8; Q6P3S6; Q86XI0; Q8N3N4; Q8N5F8; Q9BRM0; Q9P2L4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5840239989080540215" "False" "Medium" "IsMasterProtein" "Q8IVH2" "Forkhead box protein P4 OS=Homo sapiens OX=9606 GN=FOXP4 PE=1 SV=1" "0.027" "False" "1.639" "2" "1" "1" "1" "680" "73.4" "6.40" "1.89" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf16159" "116113" "ENSG00000137166" "FOXP4" "hsa:116113; Q5W098; Q7Z7F8; Q8IVH2; Q8IW55; Q96E19" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7527749598789379160" "False" "Medium" "IsMasterProtein" "O75570" "Peptide chain release factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=MTRF1 PE=1 SV=2" "0.027" "False" "1.638" "2" "1" "1" "1" "445" "52.3" "8.50" "2.58" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "nucleic acid binding activity" "Pf00472, Pf03462" "9617" "ENSG00000120662" "MTRF1" "B4DG01; hsa:9617; O75570; Q5T6Y5; Q8IUQ6" "" "" "0" "0" "1.104" "1.009" "1.101" "1.121" "1.062" "1.117" "1.030" "1.132" "0.974" "123.0" "135.9" "124.2" "135.5" "137.9" "130.7" "137.5" "126.7" "139.3" "119.9" "" "" "" "" "" "" "" "" "" "" "115.3" "112.4" "115.3" "104.7" "117.5" "124.9" "125.6" "112.5" "139.3" "115.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-879380199029803556" "False" "Medium" "IsMasterProtein" "Q9ULV0" "Unconventional myosin-Vb OS=Homo sapiens OX=9606 GN=MYO5B PE=1 SV=3" "0.027" "False" "1.637" "1" "1" "1" "1" "1848" "213.5" "7.20" "0.00" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf01843" "4645" "ENSG00000167306" "MYO5B" "B0I1R3; hsa:4645; Q0P656; Q9H6Y6; Q9ULV0" "Alstrom syndrome" "Vasopressin regulates renal water homeostasis via Aquaporins" "2" "0" "1.087" "1.128" "1.812" "1.190" "1.339" "1.323" "1.177" "0.974" "1.143" "98.1" "106.7" "110.7" "177.7" "116.8" "131.3" "129.8" "115.5" "95.5" "112.1" "" "" "" "" "" "" "" "" "" "" "91.9" "88.3" "102.8" "137.4" "99.5" "125.5" "118.6" "102.5" "95.5" "107.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6651828163835198711" "False" "Medium" "IsMasterProtein" "O95997" "Securin OS=Homo sapiens OX=9606 GN=PTTG1 PE=1 SV=1" "0.027" "False" "1.636" "3" "1" "1" "1" "202" "22.0" "6.60" "2.81" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04856" "9232" "ENSG00000164611" "PTTG1" "hsa:9232; O95997" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition" "APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1968696079756912878" "False" "Medium" "IsMasterProtein" "P22079" "Lactoperoxidase OS=Homo sapiens OX=9606 GN=LPO PE=1 SV=2" "0.027" "False" "1.626" "1" "1" "1" "1" "712" "80.2" "8.62" "2.44" "1" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf03098" "4025" "ENSG00000167419" "LPO" "A5JUY4; E7EMJ3; hsa:4025; P22079; Q13408; Q3KNQ2" "" "Events associated with phagocytolytic activity of PMN cells" "1" "0" "1.103" "1.155" "0.986" "1.100" "1.020" "1.235" "1.179" "1.285" "1.159" "265.9" "293.2" "307.2" "262.2" "292.4" "271.3" "328.4" "313.5" "341.7" "308.1" "" "" "" "" "" "" "" "" "" "" "249.2" "242.7" "285.2" "202.7" "249.2" "259.2" "300.1" "278.4" "341.7" "296.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8017112882834387390" "False" "Medium" "IsMasterProtein" "Q9Y3C0" "WASH complex subunit 3 OS=Homo sapiens OX=9606 GN=WASHC3 PE=1 SV=1" "0.027" "False" "1.624" "4" "1" "2" "1" "194" "21.2" "4.46" "4.33" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf10152" "51019" "ENSG00000120860" "WASHC3" "B2RC74; hsa:51019; Q53FF0; Q6IAI4; Q96QK0; Q9Y3C0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3626479859969264661" "False" "Medium" "IsMasterProtein" "Q96QG7" "Myotubularin-related protein 9 OS=Homo sapiens OX=9606 GN=MTMR9 PE=1 SV=1" "0.028" "False" "1.615" "1" "1" "1" "1" "549" "63.4" "6.39" "2.92" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf06602, Pf21098" "66036" "ENSG00000104643; ENSG00000285032" "MTMR9" "B7Z291; hsa:66036; Q52LU3; Q8WW11; Q96QG6; Q96QG7; Q9NX50" "8p23.1 copy number variation syndrome" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the late endosome membrane; Synthesis of IP2, IP, and Ins in the cytosol" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1961832364316848105" "False" "Medium" "IsMasterProtein" "Q9NVM4" "Protein arginine N-methyltransferase 7 OS=Homo sapiens OX=9606 GN=PRMT7 PE=1 SV=1" "0.028" "False" "1.612" "1" "1" "1" "1" "692" "78.4" "5.57" "2.46" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf06325" "54496" "ENSG00000132600" "PRMT7" "B3KPR0; B3KUG9; B4E379; hsa:54496; Q96PV5; Q9H9L0; Q9NVM4" "Nitric oxide metabolism in cystic fibrosis" "RMTs methylate histone arginines" "2" "0" "1.006" "0.990" "1.057" "1.015" "1.039" "1.037" "0.966" "1.077" "0.983" "167.2" "168.2" "165.6" "176.7" "169.7" "173.7" "173.3" "161.5" "180.1" "164.3" "" "" "" "" "" "" "" "" "" "" "156.6" "139.2" "153.7" "136.6" "144.7" "165.9" "158.3" "143.4" "180.1" "158.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-203379576220599078" "False" "Medium" "IsMasterProtein" "Q13158" "FAS-associated death domain protein OS=Homo sapiens OX=9606 GN=FADD PE=1 SV=1" "0.028" "False" "1.609" "3" "1" "1" "1" "208" "23.3" "5.69" "3.16" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00531, Pf01335" "8772" "ENSG00000168040" "FADD" "hsa:8772; Q13158; Q14866; Q6IBR4" "TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Nanoparticle triggered regulated necrosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Alzheimer's disease; Toll-like receptor signaling pathway" "Regulation of TNFR1 signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TRAIL signaling; TLR3-mediated TICAM1-dependent programmed cell death; TNFR1-induced proapoptotic signaling; FasL/ CD95L signaling; Defective RIPK1-mediated regulated necrosis" "33" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1465801585106187641" "False" "Medium" "IsMasterProtein" "P52735" "Guanine nucleotide exchange factor VAV2 OS=Homo sapiens OX=9606 GN=VAV2 PE=1 SV=2" "0.028" "False" "1.609" "2" "1" "1" "1" "878" "101.2" "7.08" "1.65" "1" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00130, Pf00169, Pf00307, Pf00621, Pf07653" "7410" "ENSG00000160293" "VAV2" "A2RUM4; A8MQ12; B6ZDF5; hsa:7410; P52735; Q5SYV3; Q5SYV4; Q5SYV5; Q6N012; Q6PIJ9; Q6Q317" "Integrin-mediated cell adhesion; Prolactin signaling pathway; B cell receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Focal adhesion; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; Ebola virus infection in host; EGF/EGFR signaling pathway; 16p11.2 distal deletion syndrome; GDNF signaling" "EPH-ephrin mediated repulsion of cells; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated phagocytosis; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; GPVI-mediated activation cascade; DAP12 signaling; Signal transduction by L1; Azathioprine ADME; VEGFR2 mediated vascular permeability" "34" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1533138465656150959" "False" "Medium" "IsMasterProtein" "Q5VWQ0" "Lysine-specific demethylase 9 OS=Homo sapiens OX=9606 GN=RSBN1 PE=1 SV=2" "0.028" "False" "1.606" "1" "1" "1" "1" "802" "90.0" "8.60" "2.74" "1" "cell organization and biogenesis" "nucleus" "other molecular function" "" "54665" "ENSG00000081019" "RSBN1" "A8K937; hsa:54665; Q5VWQ0; Q6AI21; Q8TC33; Q9HA80; Q9NUP6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4474106479109079676" "False" "Medium" "IsMasterProtein" "O00422" "Histone deacetylase complex subunit SAP18 OS=Homo sapiens OX=9606 GN=SAP18 PE=1 SV=1" "0.028" "False" "1.602" "6" "1" "1" "1" "153" "17.6" "9.35" "2.05" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06487" "10284" "ENSG00000150459" "SAP18" "B2R494; hsa:10284; O00422; Q2TTR4; Q6IAW9; Q8N606; Q9UF14; X6RAL5" "Hedgehog signaling pathway" "Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; mRNA Splicing - Major Pathway" "5" "0" "1.008" "0.945" "0.928" "0.941" "0.970" "0.877" "0.897" "0.807" "0.934" "169.0" "170.3" "159.7" "156.8" "159.0" "163.9" "148.2" "151.6" "136.3" "157.9" "" "" "" "" "" "" "" "" "" "" "158.3" "141.0" "148.3" "121.2" "135.5" "156.6" "135.4" "134.6" "136.3" "152.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5889658442620060089" "False" "Medium" "IsMasterProtein" "Q9Y3V2" "RWD domain-containing protein 3 OS=Homo sapiens OX=9606 GN=RWDD3 PE=1 SV=4" "0.029" "False" "1.599" "3" "1" "1" "1" "267" "30.5" "6.18" "0.00" "1" "other biological processes" "nucleus;other cell component" "" "Pf05773" "25950" "ENSG00000122481" "RWDD3" "A6NP44; A8K9F0; C9J9L7; C9JI45; hsa:25950; Q08AJ7; Q6FID3; Q9BX35; Q9Y3V2" "" "SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "1" "0" "0.934" "0.970" "0.906" "0.949" "0.946" "0.761" "0.745" "0.757" "0.912" "187.9" "175.5" "182.3" "170.3" "178.4" "177.9" "143.0" "139.9" "142.2" "171.4" "" "" "" "" "" "" "" "" "" "" "176.1" "145.2" "169.2" "131.7" "152.0" "169.9" "130.7" "124.2" "142.2" "165.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4224605817431316350" "False" "Medium" "IsMasterProtein" "Q96ST2" "Protein IWS1 homolog OS=Homo sapiens OX=9606 GN=IWS1 PE=1 SV=2" "0.029" "False" "1.597" "1" "1" "1" "1" "819" "91.9" "4.69" "1.67" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus" "" "Pf08711" "55677" "ENSG00000163166" "IWS1" "hsa:55677; Q2TB65; Q6P157; Q8N3E8; Q96MI7; Q96ST2; Q9NV97; Q9NWH8" "" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex" "3" "0" "0.949" "1.016" "1.117" "0.881" "0.858" "1.318" "1.332" "1.189" "0.909" "62.4" "59.2" "63.4" "69.7" "55.0" "53.5" "82.3" "83.1" "74.2" "56.8" "" "" "" "" "" "" "" "" "" "" "58.5" "49.0" "58.9" "53.9" "46.9" "51.1" "75.2" "73.8" "74.2" "54.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4924966722197614232" "False" "Medium" "IsMasterProtein" "Q8TB37" "Iron-sulfur cluster transfer protein NUBPL OS=Homo sapiens OX=9606 GN=NUBPL PE=1 SV=3" "0.029" "False" "1.597" "2" "1" "1" "1" "319" "34.1" "9.04" "2.68" "1" "cell organization and biogenesis" "plasma membrane;other membranes;mitochondrion" "other molecular function" "Pf10609" "80224" "ENSG00000151413" "NUBPL" "B4DHZ1; hsa:80224; Q86TZ4; Q8TB37; Q9H9M2" "Epithelial to mesenchymal transition in colorectal cancer" "Complex I biogenesis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6251820631680777019" "False" "Medium" "IsMasterProtein" "Q96A37" "E3 ubiquitin-protein ligase RNF166 OS=Homo sapiens OX=9606 GN=RNF166 PE=1 SV=1" "0.029" "False" "1.596" "4" "1" "1" "1" "237" "26.1" "8.06" "1.66" "1" "protein metabolism;other metabolic processes;stress response" "other cell component" "other molecular function" "Pf05605, Pf13445, Pf18574" "115992" "ENSG00000158717" "RNF166" "B3KQ03; D3DX75; H3BTU8; hsa:115992; Q96A37; Q96DM0" "" "" "0" "0" "1.138" "1.053" "1.099" "1.147" "1.033" "1.151" "1.037" "1.114" "1.093" "270.2" "307.4" "284.5" "296.9" "310.0" "279.2" "311.1" "280.2" "301.1" "295.3" "" "" "" "" "" "" "" "" "" "" "253.2" "254.4" "264.1" "229.6" "264.2" "266.8" "284.3" "248.8" "301.1" "284.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1683614988234663054" "False" "Medium" "IsMasterProtein" "Q8TC17" "GRB2-related adapter protein-like OS=Homo sapiens OX=9606 GN=GRAPL PE=1 SV=3" "0.029" "False" "1.593" "7" "1" "1" "1" "118" "13.4" "8.16" "2.50" "1" "signal transduction;other biological processes" "cytosol" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00018" "400581" "ENSG00000189152" "GRAPL" "B2RXI8; hsa:400581; Q8TC17" "" "" "0" "0" "0.959" "0.975" "1.001" "1.004" "0.995" "0.900" "0.948" "0.961" "0.971" "242.0" "232.0" "236.0" "242.1" "242.9" "240.7" "217.8" "229.5" "232.6" "235.0" "" "" "" "" "" "" "" "" "" "" "226.8" "192.0" "219.1" "187.2" "207.0" "230.0" "199.0" "203.7" "232.6" "226.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1333795596038477477" "False" "Medium" "IsMasterProtein" "P62877" "E3 ubiquitin-protein ligase RBX1 OS=Homo sapiens OX=9606 GN=RBX1 PE=1 SV=1" "0.029" "False" "1.585" "7" "1" "1" "1" "108" "12.3" "6.96" "3.61" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12678" "9978" "ENSG00000100387" "RBX1" "B2RDY1; hsa:9978; P62877; Q8N6Z8; Q9D1S2; Q9WUK9; Q9Y254" "Cell cycle; Dual hijack model of Vif in HIV infection; TGF-beta signaling pathway; Type 2 papillary renal cell carcinoma; NRF2-ARE regulation; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Nucleotide excision repair; Hijack of ubiquitination by SARS-CoV-2; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 1p36 copy number variation syndrome" "Potential therapeutics for SARS; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Degradation of DVL; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of BACH1 activity; NOTCH1 Intracellular Domain Regulates Transcription; Formation of TC-NER Pre-Incision Complex; Prolactin receptor signaling; Evasion by RSV of host interferon responses; DNA Damage Recognition in GG-NER; Nuclear events stimulated by ALK signaling in cancer; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "48" "0" "0.940" "0.941" "1.050" "1.015" "1.021" "1.043" "0.999" "0.963" "0.995" "241.3" "226.8" "227.0" "253.4" "244.9" "246.4" "251.6" "241.1" "232.4" "240.3" "" "" "" "" "" "" "" "" "" "" "226.1" "187.7" "210.8" "195.9" "208.7" "235.4" "229.9" "214.1" "232.4" "231.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1427297230371715365" "False" "Medium" "IsMasterProtein" "Q6UB99" "Ankyrin repeat domain-containing protein 11 OS=Homo sapiens OX=9606 GN=ANKRD11 PE=1 SV=3" "0.029" "False" "1.583" "0" "1" "1" "1" "2663" "297.7" "7.11" "2.66" "1" "developmental processes;other biological processes" "cytosol;nucleus" "" "Pf12796" "29123" "ENSG00000167522" "ANKRD11" "hsa:29123; Q6NTG1; Q6QMF8; Q6UB99" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3994823038495086157" "False" "Medium" "IsMasterProtein" "Q02040" "A-kinase anchor protein 17A OS=Homo sapiens OX=9606 GN=AKAP17A PE=1 SV=2" "0.030" "False" "1.578" "1" "1" "1" "1" "695" "80.7" "9.73" "3.16" "1" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "" "8227" "ENSG00000197976; ENSG00000292343" "AKAP17A" "hsa:8227; Q02040; Q02832; Q2TB98; Q5JQ74; Q5JQ76; Q8N6U9" "" "" "0" "0" "1.185" "1.210" "1.261" "1.288" "1.321" "1.684" "1.386" "1.433" "1.411" "149.1" "176.7" "180.4" "188.0" "192.1" "197.1" "251.2" "206.7" "213.6" "210.5" "" "" "" "" "" "" "" "" "" "" "139.7" "146.3" "167.5" "145.3" "163.7" "188.3" "229.5" "183.5" "213.6" "202.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3715584417028259664" "False" "Medium" "IsMasterProtein" "P56381" "ATP synthase subunit epsilon, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1E PE=1 SV=2" "0.030" "False" "1.577" "14" "1" "1" "1" "51" "5.8" "9.92" "2.53" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf04627" "514" "ENSG00000124172" "ATP5F1E" "B2RDD0; E1P5H6; hsa:514; P56381; Q53XU6" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Cristae formation; Formation of ATP by chemiosmotic coupling" "5" "0" "1.331" "1.125" "1.230" "0.961" "0.933" "0.766" "1.091" "1.035" "1.027" "270.5" "359.9" "304.2" "332.6" "260.0" "252.3" "207.1" "295.0" "280.0" "277.9" "" "" "" "" "" "" "" "" "" "" "253.4" "297.9" "282.4" "257.1" "221.7" "241.1" "189.3" "262.0" "280.0" "267.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7042305927855089094" "False" "Medium" "IsMasterProtein" "Q96E09" "PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 OS=Homo sapiens OX=9606 GN=PABIR1 PE=1 SV=1" "0.030" "False" "1.574" "3" "1" "1" "1" "287" "30.5" "6.79" "2.32" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "nucleus;other cell component" "enzyme regulator activity" "" "116224" "ENSG00000187866" "PABIR1" "hsa:116224; Q96E09" "" "" "0" "0" "0.908" "0.911" "0.984" "1.020" "0.962" "0.927" "1.020" "0.887" "0.970" "197.9" "179.7" "180.2" "194.7" "201.9" "190.4" "183.4" "201.8" "175.4" "191.9" "" "" "" "" "" "" "" "" "" "" "185.4" "148.7" "167.3" "150.5" "172.1" "181.9" "167.6" "179.2" "175.4" "184.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4880255832372389153" "False" "Medium" "IsMasterProtein" "O14832" "Phytanoyl-CoA dioxygenase, peroxisomal OS=Homo sapiens OX=9606 GN=PHYH PE=1 SV=1" "0.030" "False" "1.574" "3" "1" "1" "1" "338" "38.5" "8.47" "3.09" "1" "other metabolic processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05721" "5264" "ENSG00000107537" "PHYH" "A8MTS8; B1ALH5; hsa:5264; O14832" "" "TYSND1 cleaves peroxisomal proteins; Alpha-oxidation of phytanate" "3" "0" "0.975" "0.959" "1.028" "0.978" "0.942" "0.974" "0.966" "0.971" "0.937" "173.3" "169.0" "166.1" "178.1" "169.5" "163.2" "168.8" "167.4" "168.3" "162.4" "" "" "" "" "" "" "" "" "" "" "162.4" "139.8" "154.2" "137.7" "144.5" "155.9" "154.2" "148.6" "168.3" "156.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2262786275028472849" "False" "Medium" "IsMasterProtein" "Q9Y421" "Protein FAM32A OS=Homo sapiens OX=9606 GN=FAM32A PE=1 SV=2" "0.030" "False" "1.573" "8" "1" "1" "1" "112" "13.2" "9.99" "0.00" "1" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf08555" "26017" "ENSG00000105058" "FAM32A" "hsa:26017; Q9BT02; Q9Y421" "" "mRNA Splicing - Major Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1340431599886036183" "False" "Medium" "IsMasterProtein" "O60783" "Small ribosomal subunit protein uS14m OS=Homo sapiens OX=9606 GN=MRPS14 PE=1 SV=1" "0.030" "False" "1.572" "7" "1" "1" "1" "128" "15.1" "11.41" "1.83" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00253" "63931" "ENSG00000120333" "MRPS14" "hsa:63931; O60783; Q5R358" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-104196132274101736" "False" "Medium" "IsMasterProtein" "Q9GZT4" "Serine racemase OS=Homo sapiens OX=9606 GN=SRR PE=1 SV=1" "0.030" "False" "1.570" "3" "1" "1" "1" "340" "36.5" "6.54" "3.58" "1" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00291" "63826" "ENSG00000167720" "SRR" "D3DTI5; hsa:63826; Q6IA55; Q9GZT4" "Neuroinflammation and glutamatergic signaling" "Serine biosynthesis" "2" "0" "1.022" "0.868" "1.087" "0.978" "0.989" "1.043" "0.885" "0.977" "0.968" "243.3" "248.6" "211.3" "264.4" "237.9" "240.5" "253.8" "215.2" "237.7" "235.6" "" "" "" "" "" "" "" "" "" "" "227.9" "205.7" "196.1" "204.4" "202.8" "229.8" "231.9" "191.1" "237.7" "226.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6949912149279569323" "False" "Medium" "IsMasterProtein" "Q9BS16" "Centromere protein K OS=Homo sapiens OX=9606 GN=CENPK PE=1 SV=1" "0.030" "False" "1.568" "3" "1" "1" "1" "269" "31.6" "4.89" "2.10" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf11802" "64105" "ENSG00000123219" "CENPK" "hsa:64105; Q9BS16; Q9H4L0" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "167158526121610019" "False" "Medium" "IsMasterProtein" "Q9UPW5" "Cytosolic carboxypeptidase 1 OS=Homo sapiens OX=9606 GN=AGTPBP1 PE=1 SV=3" "0.030" "False" "1.561" "1" "1" "1" "1" "1226" "138.4" "6.15" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00246, Pf18027" "23287" "ENSG00000135049" "AGTPBP1" "B4DIT6; B4DRZ8; hsa:23287; Q5VV80; Q63HM7; Q658P5; Q6P9D6; Q9H8U6; Q9H9W8; Q9NVK1; Q9UPW5" "" "Carboxyterminal post-translational modifications of tubulin" "1" "0" "0.962" "0.894" "1.041" "0.967" "0.914" "0.939" "0.797" "0.867" "1.014" "102.3" "98.4" "91.5" "106.5" "99.0" "93.5" "96.1" "81.6" "88.7" "103.8" "" "" "" "" "" "" "" "" "" "" "95.9" "81.4" "84.9" "82.3" "84.4" "89.3" "87.8" "72.4" "88.7" "99.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1865855424515257827" "False" "Medium" "IsMasterProtein" "Q9H0F6" "Sharpin OS=Homo sapiens OX=9606 GN=SHARPIN PE=1 SV=1" "0.030" "False" "1.560" "2" "1" "1" "1" "387" "39.9" "5.80" "2.66" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf16764" "81858" "ENSG00000179526" "SHARPIN" "A6NEG3; C0L3L2; D3DWL3; hsa:81858; Q8IXF5; Q8IXF6; Q8N2E7; Q8TB25; Q9BUE4; Q9H0F6" "" "Neurexins and neuroligins; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "4" "0" "0.960" "0.943" "1.040" "0.980" "1.023" "0.992" "0.889" "0.862" "0.991" "259.1" "248.7" "244.3" "269.6" "254.1" "265.2" "257.2" "230.3" "223.4" "256.7" "" "" "" "" "" "" "" "" "" "" "242.8" "205.8" "226.8" "208.4" "216.6" "253.4" "235.0" "204.5" "223.4" "247.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6240337966017765757" "False" "Medium" "IsMasterProtein" "Q0VDG4" "Secernin-3 OS=Homo sapiens OX=9606 GN=SCRN3 PE=1 SV=1" "0.030" "False" "1.558" "1" "1" "1" "1" "424" "48.5" "5.55" "2.04" "1" "protein metabolism" "" "other molecular function" "Pf03577" "79634" "ENSG00000144306" "SCRN3" "B4DI11; C9JPC1; D3DPE0; hsa:79634; Q0VDG4; Q7L1C5; Q9H5R5" "" "" "0" "0" "0.929" "0.999" "1.001" "1.017" "0.988" "0.980" "0.920" "0.949" "1.031" "103.7" "96.3" "103.6" "103.8" "105.4" "102.5" "101.7" "95.4" "98.4" "106.9" "" "" "" "" "" "" "" "" "" "" "97.2" "79.7" "96.2" "80.2" "89.9" "97.9" "92.9" "84.7" "98.4" "103.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6452075893370782387" "False" "Medium" "IsMasterProtein" "Q96Q91" "Anion exchange protein 4 OS=Homo sapiens OX=9606 GN=SLC4A9 PE=2 SV=2" "0.030" "False" "1.557" "1" "1" "1" "1" "983" "108.2" "7.09" "2.15" "1" "transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00955, Pf07565" "83697" "ENSG00000113073" "SLC4A9" "B7ZL63; D3DQD4; D3DQD5; D3DQD6; E9PDK1; hsa:83697; Q96Q91; Q96RM5; Q9BXF2; Q9BXN3" "" "Bicarbonate transporters" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7201160367223049830" "False" "Medium" "IsMasterProtein" "Cont_Q3MHN5" "Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1" "0.030" "True" "1.557" "1" "1" "1" "1" "474" "53.3" "5.52" "2.23" "1" "transport" "non-structural extracellular;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00273, Pf09164" "530076" "" "GC" "bta:530076; Q3MHN5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2071252542434870891" "False" "Medium" "IsMasterProtein" "Q5VU43" "Myomegalin OS=Homo sapiens OX=9606 GN=PDE4DIP PE=1 SV=3" "0.030" "False" "1.555" "0" "1" "1" "1" "2346" "264.9" "5.47" "2.10" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06758, Pf07989" "9659" "ENSG00000178104" "PDE4DIP" "A0A0A0MRM0; A0A0C4DFQ0; A2RU15; E9PL24; hsa:9659; O75042; O75065; Q2YDC1; Q5VU42; Q5VU43; Q5VU44; Q5VU45; Q5VU46; Q5VU47; Q5VU48; Q5VU49; Q68DU2; Q6AZ93; Q6PK88; Q86T40; Q86TB2; Q8N3W0; Q8TAY9; Q9HCP2; Q9HCP3; Q9HCP4; Q9HCP5" "VEGFA-VEGFR2 signaling" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6210864852158670785" "False" "Medium" "IsMasterProtein" "Q9H8H2" "ATP-dependent DNA helicase DDX31 OS=Homo sapiens OX=9606 GN=DDX31 PE=1 SV=2" "0.030" "False" "1.554" "1" "1" "1" "1" "851" "94.0" "9.99" "1.65" "1" "other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf13959" "64794" "ENSG00000125485" "DDX31" "hsa:64794; Q5K6N2; Q5K6N3; Q5K6N4; Q5VZJ4; Q5VZJ9; Q96E91; Q96NY2; Q96SX5; Q9H5K6; Q9H8H2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1923861490419149454" "False" "Medium" "IsMasterProtein" "Q86UA6" "RPA-interacting protein OS=Homo sapiens OX=9606 GN=RPAIN PE=1 SV=2" "0.031" "False" "1.546" "3" "1" "1" "1" "219" "24.8" "4.87" "3.31" "1" "transport;other biological processes" "nucleus;other cell component" "other molecular function" "Pf14766, Pf14767, Pf14768" "84268" "ENSG00000129197" "RPAIN" "A0A0B4J1T3; B4DI36; B4DTX7; E9PDG9; E9PES3; J3KNH8; Q4G2Y0; Q4G2Y5; Q4G2Y8; Q6B4V9; Q6B4W0; Q6B4W1; Q6B4W4; Q86UA6; Q86X49; Q9BT00" "" "" "0" "0" "1.012" "1.026" "0.943" "0.990" "0.995" "0.905" "0.966" "0.955" "1.010" "385.3" "390.1" "395.2" "363.5" "381.3" "383.6" "348.6" "372.1" "368.0" "389.0" "" "" "" "" "" "" "" "" "" "" "361.0" "322.8" "366.9" "281.0" "325.0" "366.5" "318.5" "330.4" "368.0" "374.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6672818226938341619" "False" "Medium" "IsMasterProtein" "Q16816" "Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform OS=Homo sapiens OX=9606 GN=PHKG1 PE=1 SV=3" "0.031" "False" "1.540" "2" "1" "1" "1" "387" "45.0" "6.86" "2.64" "1" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069" "5260" "ENSG00000164776" "PHKG1" "B7Z1D0; F5H2S1; hsa:5260; Q16816; Q75LP5" "Glycogen synthesis and degradation" "Glycogen breakdown (glycogenolysis)" "2" "0" "0.995" "0.961" "1.112" "0.884" "0.953" "0.864" "0.842" "0.873" "0.985" "247.0" "245.8" "237.3" "274.6" "218.3" "235.4" "213.4" "208.0" "215.5" "243.3" "" "" "" "" "" "" "" "" "" "" "231.4" "203.4" "220.3" "212.3" "186.1" "224.9" "194.9" "184.7" "215.5" "234.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1530095289376032453" "False" "Medium" "IsMasterProtein" "Q9HBH1" "Peptide deformylase, mitochondrial OS=Homo sapiens OX=9606 GN=PDF PE=1 SV=1" "0.031" "False" "1.539" "3" "1" "2" "1" "243" "27.0" "9.16" "5.38" "1" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf01327" "64146" "ENSG00000258429" "PDF" "hsa:64146; Q8WUN6; Q9HBH1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-658427898063884792" "False" "Medium" "IsMasterProtein" "Q9P2N7" "Kelch-like protein 13 OS=Homo sapiens OX=9606 GN=KLHL13 PE=1 SV=3" "0.031" "False" "1.539" "2" "1" "1" "1" "655" "73.8" "6.62" "2.38" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00651, Pf01344, Pf07707" "90293" "ENSG00000003096" "KLHL13" "B3KV78; B3KWM7; B7Z3S9; B7Z5P2; B7Z802; D3DWH6; hsa:90293; Q6P2E3; Q96QI7; Q9P2N7; Q9UDN9" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3996137015870580469" "False" "Medium" "IsMasterProtein" "Q8N608" "Inactive dipeptidyl peptidase 10 OS=Homo sapiens OX=9606 GN=DPP10 PE=1 SV=2" "0.031" "False" "1.537" "2" "1" "1" "1" "796" "90.8" "6.57" "2.37" "1" "protein metabolism;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00326, Pf00930" "57628" "ENSG00000175497" "DPP10" "A8K1Q2; hsa:57628; J3KPP2; J3KQ46; Q0GLB8; Q53QT3; Q53S86; Q53SL8; Q53SS4; Q6TTV4; Q86YR9; Q8N608; Q9P236" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8664805599119289784" "False" "Medium" "IsMasterProtein" "Q7Z3I7" "Zinc finger protein 572 OS=Homo sapiens OX=9606 GN=ZNF572 PE=1 SV=1" "0.031" "False" "1.536" "2" "1" "1" "1" "529" "61.2" "8.00" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "137209" "ENSG00000180938" "ZNF572" "A1L4E9; A1L4F1; hsa:137209; Q7Z3I7; Q8N1Q0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "442559645586746814" "False" "Medium" "IsMasterProtein" "Q9H6R3" "Acyl-CoA synthetase short-chain family member 3, mitochondrial OS=Homo sapiens OX=9606 GN=ACSS3 PE=1 SV=1" "0.032" "False" "1.531" "2" "1" "1" "1" "686" "74.7" "8.63" "1.67" "1" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00501, Pf13193, Pf16177" "79611" "ENSG00000111058" "ACSS3" "hsa:79611; Q8NC66; Q9H6R3" "" "Synthesis of Ketone Bodies" "1" "0" "1.122" "1.166" "1.170" "1.136" "1.206" "0.999" "0.996" "1.104" "1.178" "88.9" "99.8" "103.7" "104.0" "101.0" "107.2" "88.8" "88.5" "98.2" "104.7" "" "" "" "" "" "" "" "" "" "" "83.3" "82.5" "96.2" "80.4" "86.1" "102.4" "81.2" "78.6" "98.2" "100.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8778446884232701791" "False" "Medium" "IsMasterProtein" "Q9UK97" "F-box only protein 9 OS=Homo sapiens OX=9606 GN=FBXO9 PE=1 SV=1" "0.032" "False" "1.529" "2" "1" "1" "1" "447" "52.3" "6.15" "2.19" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00646, Pf19270" "26268" "ENSG00000112146" "FBXO9" "A6NFW3; B3KMM6; hsa:26268; O75986; Q59EH8; Q6PKH7; Q9NT57; Q9UK97; Q9Y593" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8964751153975728348" "False" "Medium" "IsMasterProtein" "Q96RE7" "Nucleus accumbens-associated protein 1 OS=Homo sapiens OX=9606 GN=NACC1 PE=1 SV=1" "0.032" "False" "1.528" "1" "1" "1" "1" "527" "57.2" "5.74" "2.72" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651, Pf10523" "112939" "ENSG00000160877" "NACC1" "hsa:112939; Q96RE7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4783796531760009514" "False" "Medium" "IsMasterProtein" "Q9Y228" "TRAF3-interacting JNK-activating modulator OS=Homo sapiens OX=9606 GN=TRAF3IP3 PE=1 SV=2" "0.032" "False" "1.526" "1" "1" "1" "1" "551" "63.6" "8.51" "3.41" "1" "other biological processes" "plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle" "other molecular function" "" "80342" "ENSG00000009790" "TRAF3IP3" "A1L464; A6NIU9; hsa:80342; Q2YDB5; Q4VY06; Q7Z706; Q9Y228" "" "" "0" "0" "1.048" "1.122" "1.032" "1.049" "1.129" "1.045" "1.053" "1.077" "1.130" "285.9" "299.6" "320.8" "295.0" "299.9" "322.7" "298.8" "301.0" "307.8" "323.1" "" "" "" "" "" "" "" "" "" "" "267.9" "247.9" "297.8" "228.1" "255.6" "308.4" "273.0" "267.2" "307.8" "311.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2065184215663256400" "False" "Medium" "IsMasterProtein" "Q5TKA1" "Protein lin-9 homolog OS=Homo sapiens OX=9606 GN=LIN9 PE=1 SV=1" "0.032" "False" "1.525" "2" "1" "1" "1" "542" "61.9" "9.04" "2.08" "1" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf06584, Pf19438" "286826" "ENSG00000183814" "LIN9" "hsa:286826; Q5TKA1; Q5U5L8; Q5U7E1; Q6PI55; Q6ZTV4; Q7Z3J1" "Gastric cancer network 1; DYRK1A involvement regarding cell proliferation in brain development" "G1/S-Specific Transcription; Polo-like kinase mediated events; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8654378889917812669" "False" "Medium" "IsMasterProtein" "Q9BQ90" "Kelch domain-containing protein 3 OS=Homo sapiens OX=9606 GN=KLHDC3 PE=1 SV=1" "0.032" "False" "1.520" "3" "1" "1" "1" "382" "43.1" "8.07" "2.42" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01344, Pf07646, Pf13418, Pf13964" "116138" "ENSG00000124702" "KLHDC3" "A8K2W9; hsa:116138; Q9BQ90" "" "XBP1(S) activates chaperone genes" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5444771599092088743" "False" "Medium" "IsMasterProtein" "Q96EY9" "Probable inactive tRNA-specific adenosine deaminase-like protein 3 OS=Homo sapiens OX=9606 GN=ADAT3 PE=1 SV=1" "0.032" "False" "1.519" "2" "1" "1" "1" "351" "38.0" "7.88" "2.32" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00383" "113179" "" "ADAT3" "hsa:113179; Q96EY9" "" "tRNA modification in the nucleus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7298990959993915451" "False" "Medium" "IsMasterProtein" "Q96SD1" "Protein artemis OS=Homo sapiens OX=9606 GN=DCLRE1C PE=1 SV=2" "0.032" "False" "1.515" "1" "1" "1" "1" "692" "78.4" "6.02" "0.00" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07522" "64421" "ENSG00000152457" "DCLRE1C" "D3DRT6; hsa:64421; Q1HCL2; Q5JSR4; Q5JSR5; Q5JSR7; Q5JSR8; Q5JSR9; Q5JSS0; Q5JSS7; Q6PK14; Q8N101; Q8N132; Q8TBW9; Q96SD1; Q9BVW9; Q9HAM4" "ATM signaling in development and disease ; Non-homologous end joining; DNA repair pathways, full network" "Nonhomologous End-Joining (NHEJ)" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-21239567639981216" "False" "Medium" "IsMasterProtein" "Q9BRA0" "N-alpha-acetyltransferase 38, NatC auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA38 PE=1 SV=1" "0.032" "False" "1.512" "7" "1" "1" "1" "125" "13.5" "5.53" "2.46" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "84316" "ENSG00000183011" "NAA38" "hsa:84316; Q8N4M0; Q9BRA0" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4156971201589500913" "False" "Medium" "IsMasterProtein" "P85298" "Rho GTPase-activating protein 8 OS=Homo sapiens OX=9606 GN=ARHGAP8 PE=1 SV=1" "0.032" "False" "1.511" "2" "1" "1" "1" "464" "53.5" "9.41" "2.06" "1" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00620, Pf13716" "23779" "ENSG00000241484" "ARHGAP8" "A6ZJ79; A6ZJ80; hsa:23779; O75983; O95695; P85298; Q96RW1; Q96RW2; Q9HA49; Q9HC46; Q9NSG0; Q9NVX8; Q9NXL1; Q9UH20" "" "RHOA GTPase cycle" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4349048181346245429" "False" "Medium" "IsMasterProtein" "Q9Y6B7" "AP-4 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP4B1 PE=1 SV=2" "0.032" "False" "1.511" "1" "1" "1" "1" "739" "83.2" "5.86" "2.51" "1" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf01602, Pf09066" "10717" "ENSG00000134262" "AP4B1" "B7Z4X3; hsa:10717; Q59EJ4; Q96CL6; Q9Y6B7" "" "Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6021444630148813561" "False" "Medium" "IsMasterProtein" "Q9BVG8" "Kinesin-like protein KIFC3 OS=Homo sapiens OX=9606 GN=KIFC3 PE=1 SV=4" "0.032" "False" "1.510" "1" "1" "1" "1" "833" "92.7" "7.69" "0.00" "1" "cell adhesion;cell organization and biogenesis;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3801" "ENSG00000140859" "KIFC3" "A8K6S2; B7Z484; hsa:3801; O75299; Q49A29; Q49AQ0; Q59G19; Q8IUT3; Q96HW6; Q9BVG8" "Ectoderm differentiation; IL-18 signaling pathway" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "387449412879448660" "False" "Medium" "IsMasterProtein" "Q92782" "Zinc finger protein neuro-d4 OS=Homo sapiens OX=9606 GN=DPF1 PE=1 SV=3" "0.032" "False" "1.508" "3" "1" "1" "1" "387" "44.1" "7.08" "2.48" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00628, Pf14051" "8193" "ENSG00000011332" "DPF1" "B3KSY8; hsa:8193; Q08AJ0; Q92782" "Tumor suppressor activity of SMARCB1; Thermogenesis" "" "2" "0" "1.031" "1.037" "1.043" "0.921" "1.036" "1.047" "1.027" "1.004" "1.073" "84.8" "87.4" "87.9" "88.5" "78.1" "87.9" "88.8" "87.1" "85.2" "91.0" "" "" "" "" "" "" "" "" "" "" "79.5" "72.4" "81.6" "68.4" "66.6" "84.0" "81.2" "77.3" "85.2" "87.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4622932999208517122" "False" "Medium" "IsMasterProtein" "Q96HR8" "H/ACA ribonucleoprotein complex non-core subunit NAF1 OS=Homo sapiens OX=9606 GN=NAF1 PE=1 SV=2" "0.032" "False" "1.506" "1" "1" "1" "1" "494" "53.7" "4.87" "1.86" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04410" "92345" "ENSG00000145414" "NAF1" "D3DP28; E9PAZ2; hsa:92345; Q96HR8" "" "" "0" "0" "0.703" "0.720" "0.743" "0.723" "0.986" "0.684" "0.671" "0.696" "0.718" "617.0" "433.6" "444.5" "458.4" "446.2" "608.5" "421.9" "414.3" "429.5" "443.0" "" "" "" "" "" "" "" "" "" "" "578.1" "358.8" "412.7" "354.3" "380.4" "581.4" "385.5" "367.9" "429.5" "426.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8995657341512938219" "False" "Medium" "IsMasterProtein" "P47914" "Large ribosomal subunit protein eL29 OS=Homo sapiens OX=9606 GN=RPL29 PE=1 SV=2" "0.032" "False" "1.505" "5" "1" "1" "1" "159" "17.7" "11.66" "2.27" "1" "protein metabolism;other metabolic processes;developmental processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01779" "6159" "ENSG00000162244" "RPL29" "A8K0H3; B2R4M8; hsa:6159; P47914; Q6IPY3" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3246576723643333795" "False" "Medium" "IsMasterProtein" "Q8N668" "COMM domain-containing protein 1 OS=Homo sapiens OX=9606 GN=COMMD1 PE=1 SV=1" "0.032" "False" "1.504" "4" "1" "1" "1" "190" "21.2" "6.20" "2.00" "1" "DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07258, Pf17221" "150684" "ENSG00000173163" "COMMD1" "B4DFQ4; hsa:150684; Q8N668; Q96GS0" "Copper homeostasis; 1p36 copy number variation syndrome" "Neddylation" "3" "0" "0.901" "0.900" "0.944" "0.902" "0.974" "0.926" "0.857" "0.868" "0.902" "242.2" "218.2" "218.0" "228.7" "218.3" "235.9" "224.3" "207.4" "210.1" "218.4" "" "" "" "" "" "" "" "" "" "" "226.9" "180.5" "202.4" "176.8" "186.1" "225.3" "204.9" "184.2" "210.1" "210.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7975170816643306332" "False" "Medium" "IsMasterProtein" "O43543" "DNA repair protein XRCC2 OS=Homo sapiens OX=9606 GN=XRCC2 PE=1 SV=1" "0.032" "False" "1.503" "3" "1" "1" "1" "280" "31.9" "6.04" "2.05" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "7516" "ENSG00000196584" "XRCC2" "B2R925; hsa:7516; O43543" "Male infertility; Primary ovarian insufficiency" "Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "461766419271879158" "False" "Medium" "IsMasterProtein" "Q96BR1" "Serine/threonine-protein kinase Sgk3 OS=Homo sapiens OX=9606 GN=SGK3 PE=1 SV=1" "0.033" "False" "1.499" "2" "1" "1" "1" "496" "57.1" "6.93" "0.00" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;other cytoplasmic organelle" "kinase activity;other molecular function" "Pf00069, Pf00433, Pf00787" "100533105; 23678" "ENSG00000104205" "SGK3" "A8K5W3; B3KQC2; hsa:100533105; hsa:23678; Q96BR1; Q9P1Q7; Q9UKG5" "PI3K-Akt signaling pathway; Insulin signaling; HDAC6 interactions in the central nervous system" "Stimuli-sensing channels" "4" "0" "0.965" "0.979" "1.053" "0.962" "1.001" "0.934" "0.955" "0.940" "0.893" "132.3" "127.7" "129.5" "139.3" "127.3" "132.4" "123.6" "126.3" "124.4" "118.1" "" "" "" "" "" "" "" "" "" "" "124.0" "105.7" "120.3" "107.7" "108.5" "126.5" "112.9" "112.2" "124.4" "113.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "734250043703742663" "False" "Medium" "IsMasterProtein" "Q9Y6H3" "Mitochondrial inner membrane protease ATP23 homolog OS=Homo sapiens OX=9606 GN=ATP23 PE=1 SV=3" "0.033" "False" "1.496" "2" "1" "1" "1" "246" "28.1" "8.03" "2.22" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf09768" "91419" "ENSG00000166896; ENSG00000262145" "ATP23" "hsa:91419; Q1RLM4; Q96E81; Q9Y6H3" "" "" "0" "0" "0.947" "1.180" "0.945" "0.966" "0.922" "0.771" "0.858" "0.966" "0.973" "128.4" "121.6" "151.5" "121.3" "124.0" "118.3" "99.0" "110.1" "123.9" "124.9" "" "" "" "" "" "" "" "" "" "" "120.3" "100.6" "140.7" "93.8" "105.7" "113.1" "90.5" "97.8" "123.9" "120.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1630467620585670619" "False" "Medium" "IsMasterProtein" "Q9Y6K1" "DNA (cytosine-5)-methyltransferase 3A OS=Homo sapiens OX=9606 GN=DNMT3A PE=1 SV=4" "0.033" "False" "1.495" "1" "1" "1" "1" "912" "101.8" "6.57" "2.60" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00145, Pf00855, Pf17980, Pf21255" "1788" "ENSG00000119772" "DNMT3A" "E9PEB8; hsa:1788; Q86TE8; Q86XF5; Q8IZV0; Q8WXU9; Q9Y6K1" "One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; One-carbon metabolism and related pathways; MTHFR deficiency; Opioid receptor pathways; Spina bifida" "RMTs methylate histone arginines; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; SUMOylation of DNA methylation proteins" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8244931832406879896" "False" "Medium" "IsMasterProtein" "P78424" "POU domain, class 6, transcription factor 2 OS=Homo sapiens OX=9606 GN=POU6F2 PE=1 SV=3" "0.033" "False" "1.494" "1" "1" "1" "1" "691" "73.2" "7.77" "2.75" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00157" "11281" "ENSG00000106536" "POU6F2" "A4D1W2; C4AMB9; hsa:11281; P78424; P78425; Q75ME8; Q86UM6; Q9UDS7" "" "" "0" "0" "1.030" "0.980" "1.020" "1.007" "0.942" "0.971" "0.986" "1.000" "0.932" "212.2" "218.6" "208.0" "216.5" "213.6" "199.9" "206.0" "209.2" "212.1" "197.9" "" "" "" "" "" "" "" "" "" "" "198.8" "180.9" "193.1" "167.4" "182.1" "191.0" "188.2" "185.7" "212.1" "190.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4658172871140468528" "False" "Medium" "IsMasterProtein" "Q9P2B4" "CTTNBP2 N-terminal-like protein OS=Homo sapiens OX=9606 GN=CTTNBP2NL PE=1 SV=2" "0.033" "False" "1.492" "2" "1" "1" "1" "639" "70.1" "8.06" "1.76" "1" "protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf09727" "55917" "ENSG00000143079" "CTTNBP2NL" "B3KMS5; hsa:55917; Q96B40; Q9P2B4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "190648059904117416" "False" "Medium" "IsMasterProtein" "Q9UQ90" "Mitochondrial inner membrane m-AAA protease component paraplegin OS=Homo sapiens OX=9606 GN=SPG7 PE=1 SV=2" "0.033" "False" "1.491" "2" "1" "1" "1" "795" "88.2" "8.69" "1.62" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00004, Pf01434, Pf06480, Pf17862" "6687" "ENSG00000197912" "SPG7" "hsa:6687; O75756; Q2TB70; Q58F00; Q96IB0; Q9UQ90" "" "Mitochondrial protein degradation; Processing of SMDT1" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5631712857688856079" "False" "Medium" "IsMasterProtein" "Q9P0K8" "Forkhead box protein J2 OS=Homo sapiens OX=9606 GN=FOXJ2 PE=1 SV=1" "0.033" "False" "1.490" "2" "1" "1" "1" "574" "62.4" "6.70" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250" "55810" "ENSG00000065970" "FOXJ2" "A0AVK4; B2RMP3; hsa:55810; Q96PS9; Q9NSN5; Q9P0K8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4533172368579844457" "False" "Medium" "IsMasterProtein" "P55055" "Oxysterols receptor LXR-beta OS=Homo sapiens OX=9606 GN=NR1H2 PE=1 SV=2" "0.033" "False" "1.485" "2" "1" "1" "1" "460" "50.9" "7.74" "3.11" "1" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00104, Pf00105" "7376" "ENSG00000131408" "NR1H2" "A8K490; B4DNM6; E7EWA6; hsa:7376; P55055; Q12970; Q5I0Y1" "Nuclear receptors; Sterol regulatory element-binding proteins (SREBP) signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways" "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; PPARA activates gene expression; Nuclear Receptor transcription pathway; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis; SUMOylation of intracellular receptors; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose; VLDLR internalisation and degradation; NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6861337530057476135" "False" "Medium" "IsMasterProtein" "Q8NGK5" "Olfactory receptor 52M1 OS=Homo sapiens OX=9606 GN=OR52M1 PE=3 SV=1" "0.033" "False" "1.485" "3" "1" "1" "1" "317" "35.0" "8.66" "2.72" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf13853" "119772" "ENSG00000197790" "OR52M1" "hsa:119772; Q8NGK5" "" "Expression and translocation of olfactory receptors" "1" "0" "0.907" "0.976" "1.177" "0.964" "1.037" "0.973" "0.963" "0.921" "1.014" "163.4" "148.2" "159.5" "192.3" "157.5" "169.5" "159.0" "157.3" "150.5" "165.6" "" "" "" "" "" "" "" "" "" "" "153.1" "122.6" "148.0" "148.7" "134.3" "161.9" "145.3" "139.7" "150.5" "159.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4890838603995560375" "False" "Medium" "IsMasterProtein" "Q6ZMN7" "PDZ domain-containing RING finger protein 4 OS=Homo sapiens OX=9606 GN=PDZRN4 PE=1 SV=3" "0.033" "False" "1.481" "1" "1" "1" "1" "1036" "117.0" "5.87" "0.00" "1" "" "" "other molecular function" "Pf00595, Pf13923" "29951" "ENSG00000165966" "PDZRN4" "hsa:29951; Q52LY3; Q52LY4; Q6N052; Q6ZMN7; Q8IUU1; Q9NTP7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1812209145391096347" "False" "Medium" "IsMasterProtein" "P07919" "Cytochrome b-c1 complex subunit 6, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRH PE=1 SV=2" "0.034" "False" "1.476" "8" "1" "2" "1" "91" "10.7" "4.44" "4.55" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf02320" "7388" "ENSG00000173660" "UQCRH" "B2R4V9; D3DQ18; hsa:7388; P07919; Q5TDF6; Q6LDB8; Q9BQ91" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "Respiratory electron transport" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8360572772307666669" "False" "Medium" "IsMasterProtein" "O75095" "Multiple epidermal growth factor-like domains protein 6 OS=Homo sapiens OX=9606 GN=MEGF6 PE=1 SV=4" "0.034" "False" "1.475" "1" "1" "1" "1" "1541" "161.1" "6.38" "0.00" "1" "" "non-structural extracellular" "other molecular function" "Pf00053, Pf07645, Pf12662, Pf14670" "1953" "ENSG00000162591" "MEGF6" "hsa:1953; O75095; Q4AC86; Q5VV39" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "706443412800658116" "False" "Medium" "IsMasterProtein" "O14683" "Tumor protein p53-inducible protein 11 OS=Homo sapiens OX=9606 GN=TP53I11 PE=1 SV=2" "0.034" "False" "1.474" "5" "1" "1" "1" "189" "21.0" "9.55" "1.99" "1" "other biological processes" "other membranes" "" "Pf14936" "9537" "ENSG00000175274" "TP53I11" "hsa:9537; O14683; Q3ZCS0" "11p11.2 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1918170564219307244" "False" "Medium" "IsMasterProtein" "Q9H2E6" "Semaphorin-6A OS=Homo sapiens OX=9606 GN=SEMA6A PE=1 SV=3" "0.034" "False" "1.471" "1" "1" "1" "1" "1030" "114.3" "8.41" "1.98" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding" "Pf01403, Pf01437" "57556" "ENSG00000092421" "SEMA6A" "hsa:57556; Q9H2E6; Q9P2H9" "Spinal cord injury" "Other semaphorin interactions" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2798793094754646619" "False" "Medium" "IsMasterProtein" "Q9HA92" "Radical S-adenosyl methionine domain-containing protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=RSAD1 PE=1 SV=2" "0.034" "False" "1.469" "2" "1" "1" "1" "442" "48.7" "7.78" "2.00" "1" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf04055, Pf06969" "55316" "ENSG00000136444" "RSAD1" "B4DMW0; hsa:55316; Q53HV8; Q86VC4; Q9BRY7; Q9HA92; Q9NUS7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1865861446448502197" "False" "Medium" "IsMasterProtein" "Q9Y2U9" "Kelch domain-containing protein 2 OS=Homo sapiens OX=9606 GN=KLHDC2 PE=1 SV=1" "0.034" "False" "1.467" "2" "1" "1" "1" "406" "46.1" "6.61" "1.69" "1" "protein metabolism;other metabolic processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf13418" "23588" "ENSG00000165516" "KLHDC2" "B3KPF9; hsa:23588; Q6IAF0; Q86TY9; Q9Y2U9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1668082602578177329" "False" "Medium" "IsMasterProtein" "O95625" "Zinc finger and BTB domain-containing protein 11 OS=Homo sapiens OX=9606 GN=ZBTB11 PE=1 SV=2" "0.034" "False" "1.465" "1" "1" "1" "1" "1053" "119.3" "8.66" "1.63" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651, Pf13912, Pf17921" "27107" "ENSG00000066422" "ZBTB11" "hsa:27107; O95625; Q2NKP9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5290020876166637523" "False" "Medium" "IsMasterProtein" "O95201" "Transcriptional repressor RHIT OS=Homo sapiens OX=9606 GN=ZNF205 PE=1 SV=2" "0.034" "False" "1.465" "1" "1" "1" "1" "554" "60.6" "8.54" "0.00" "1" "cell organization and biogenesis;transport;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "7755" "ENSG00000122386" "ZNF205" "A8MZK0; D3DUB4; hsa:7755; I0J0A3; O95201; Q9BU95" "" "Generic Transcription Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "552673094407131667" "False" "Medium" "IsMasterProtein" "O95639" "Cleavage and polyadenylation specificity factor subunit 4 OS=Homo sapiens OX=9606 GN=CPSF4 PE=1 SV=1" "0.034" "False" "1.465" "3" "1" "2" "1" "269" "30.2" "8.31" "1.87" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098, Pf00642, Pf15663" "10898" "ENSG00000160917" "CPSF4" "D6W5S8; hsa:10898; O95639; Q6FGE6; Q86TF8; Q9BTW6" "mRNA processing" "Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4077783620514139312" "False" "Medium" "IsMasterProtein" "Q15650" "Activating signal cointegrator 1 OS=Homo sapiens OX=9606 GN=TRIP4 PE=1 SV=4" "0.034" "False" "1.463" "1" "1" "1" "1" "581" "66.1" "7.85" "2.33" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04266, Pf06221" "9325" "ENSG00000103671" "TRIP4" "B2RAS0; hsa:9325; Q15650; Q96ED7; Q9UKH0" "VEGFA-VEGFR2 signaling" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-345522786131708725" "False" "Medium" "IsMasterProtein" "Q14571" "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 OS=Homo sapiens OX=9606 GN=ITPR2 PE=1 SV=2" "0.034" "False" "1.462" "0" "1" "1" "1" "2701" "307.9" "6.43" "2.70" "1" "stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00520, Pf01365, Pf02815, Pf08454, Pf08709" "3709" "ENSG00000123104" "ITPR2" "hsa:3709; O94773; Q14571" "Alzheimer's disease and miRNA effects; Myometrial relaxation and contraction pathways; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Alzheimer's disease; GDNF signaling; Calcium regulation in cardiac cells" "Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Ca2+ pathway; VEGFR2 mediated cell proliferation; Elevation of cytosolic Ca2+ levels; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation; Effects of PIP2 hydrolysis" "21" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6553224162090552303" "False" "Medium" "IsMasterProtein" "Q9Y3A3" "MOB-like protein phocein OS=Homo sapiens OX=9606 GN=MOB4 PE=1 SV=1" "0.034" "False" "1.461" "3" "1" "1" "1" "225" "26.0" "5.78" "0.00" "1" "" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf03637" "25843" "ENSG00000115540" "MOB4" "B4DML0; hsa:25843; Q53SE0; Q7Z4Y6; Q9H2P3; Q9H5J1; Q9Y3A3; Q9Y4T8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8677179923960499603" "False" "Medium" "IsMasterProtein" "Q86UD0" "Suppressor APC domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SAPCD2 PE=1 SV=2" "0.034" "False" "1.461" "2" "1" "1" "1" "394" "42.6" "8.82" "1.74" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf11414" "89958" "ENSG00000186193" "SAPCD2" "hsa:89958; Q86UD0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6542894838641054893" "False" "Medium" "IsMasterProtein" "Q96C24" "Synaptotagmin-like protein 4 OS=Homo sapiens OX=9606 GN=SYTL4 PE=1 SV=2" "0.034" "False" "1.460" "1" "1" "1" "1" "671" "76.0" "8.98" "0.00" "1" "cell-cell signaling;cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "signal transduction activity or receptor binding;other molecular function" "Pf00168, Pf02318" "94121" "ENSG00000102362" "SYTL4" "hsa:94121; Q5H9J3; Q5JPG8; Q8N9P4; Q96C24; Q9H4R0; Q9H4R1" "Deregulation of Rab and Rab effector genes in bladder cancer" "Platelet degranulation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4405747288759023337" "False" "Medium" "IsMasterProtein" "Q8NG08" "DNA helicase B OS=Homo sapiens OX=9606 GN=HELB PE=1 SV=2" "0.034" "False" "1.458" "1" "1" "1" "1" "1087" "123.2" "5.87" "2.28" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf13538, Pf13604" "92797" "ENSG00000127311" "HELB" "A8K4C9; hsa:92797; Q4G0T2; Q8NG08; Q9H7L5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7667795813470499139" "False" "Medium" "IsMasterProtein" "Q9P0K1" "Disintegrin and metalloproteinase domain-containing protein 22 OS=Homo sapiens OX=9606 GN=ADAM22 PE=1 SV=1" "0.035" "False" "1.453" "1" "1" "1" "1" "906" "100.4" "7.20" "2.19" "1" "cell adhesion;protein metabolism;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00200, Pf01421, Pf01562, Pf07974, Pf08516" "53616" "ENSG00000008277" "ADAM22" "hsa:53616; O75075; O75076; Q9P0K1; Q9P0K2; Q9UIA1; Q9UKK2" "" "LGI-ADAM interactions" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3603271741719769856" "False" "Medium" "IsMasterProtein" "Q9HCM1" "Retroelement silencing factor 1 OS=Homo sapiens OX=9606 GN=RESF1 PE=1 SV=3" "0.036" "False" "1.447" "1" "1" "1" "1" "1747" "194.7" "8.78" "2.15" "1" "other biological processes" "nucleus" "other molecular function" "Pf15395" "55196" "ENSG00000174718" "RESF1" "B2RTU5; hsa:55196; Q4KN17; Q9HCM1; Q9NVL6; Q9NWP9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1762816792767039111" "False" "Medium" "IsMasterProtein" "Q9UJJ7" "RNA pseudouridylate synthase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RPUSD1 PE=1 SV=1" "0.036" "False" "1.442" "2" "1" "1" "1" "312" "34.7" "7.05" "2.40" "1" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf00849" "113000" "ENSG00000007376" "RPUSD1" "D3DU66; hsa:113000; Q9UJJ7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5564518688305977023" "False" "Medium" "IsMasterProtein" "Q9H633" "Ribonuclease P protein subunit p21 OS=Homo sapiens OX=9606 GN=RPP21 PE=1 SV=1" "0.036" "False" "1.441" "6" "1" "1" "1" "154" "17.6" "9.45" "1.80" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04032" "79897" "ENSG00000239865; ENSG00000239927; ENSG00000241370; ENSG00000241779; ENSG00000241863; ENSG00000242726; ENSG00000243009" "RPP21" "A2AAZ8; B0S834; B0S835; hsa:79897; Q5JPL9; Q5JPM1; Q5STF8; Q5STF9; Q5STG2; Q5SU41; Q5SU42; Q86Y49; Q86Y50; Q86Y51; Q96F16; Q9H633" "" "Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus" "2" "0" "1.284" "0.957" "1.169" "1.064" "1.132" "1.213" "1.066" "1.012" "1.099" "37.0" "47.5" "35.4" "43.2" "39.3" "41.8" "44.8" "39.4" "37.4" "40.6" "" "" "" "" "" "" "" "" "" "" "34.6" "39.3" "32.8" "33.4" "33.5" "40.0" "41.0" "35.0" "37.4" "39.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3944939482947776682" "False" "Medium" "IsMasterProtein" "P00480" "Ornithine transcarbamylase, mitochondrial OS=Homo sapiens OX=9606 GN=OTC PE=1 SV=3" "0.036" "False" "1.439" "2" "1" "2" "1" "354" "39.9" "8.63" "3.55" "1" "other metabolic processes;developmental processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00185, Pf02729" "5009" "ENSG00000036473" "OTC" "A8K9P2; D3DWB0; hsa:5009; P00480; Q3KNR1; Q6B0I1; Q9NYJ5" "Amino acid metabolism" "Mitochondrial protein import; Urea cycle" "3" "0" "0.750" "0.988" "1.029" "0.974" "0.872" "1.044" "0.864" "0.821" "0.895" "454.4" "341.0" "448.7" "467.6" "442.4" "396.2" "474.5" "392.6" "373.0" "406.7" "" "" "" "" "" "" "" "" "" "" "425.8" "282.2" "416.6" "361.5" "377.1" "378.6" "433.5" "348.6" "373.0" "391.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3477378732405532846" "False" "Medium" "IsMasterProtein" "Q5TCX8" "Mitogen-activated protein kinase kinase kinase 21 OS=Homo sapiens OX=9606 GN=MAP3K21 PE=1 SV=3" "0.037" "False" "1.438" "1" "1" "1" "1" "1036" "113.9" "8.73" "0.00" "1" "protein metabolism;other metabolic processes;signal transduction" "other cell component" "kinase activity;other molecular function" "Pf07714, Pf14604" "84451" "ENSG00000143674" "MAP3K21" "A0A1W2PKR9; B2RN34; hsa:84451; Q5TCX7; Q5TCX8; Q5TCX9; Q8WWN1; Q8WWN2; Q96JM1; X6R610" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8314583423527293992" "False" "Medium" "IsMasterProtein" "Q96SZ6" "Mitochondrial tRNA methylthiotransferase CDK5RAP1 OS=Homo sapiens OX=9606 GN=CDK5RAP1 PE=1 SV=2" "0.037" "False" "1.435" "2" "1" "1" "1" "601" "67.6" "8.21" "2.12" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00919, Pf01938, Pf04055" "51654" "ENSG00000101391" "CDK5RAP1" "A8K7R0; hsa:51654; Q5QP46; Q5QP47; Q5QP48; Q675N4; Q675N5; Q96SZ6; Q9BVG6; Q9BWZ5; Q9H859; Q9NZZ9; Q9Y3F0" "" "" "0" "0" "0.898" "1.197" "1.124" "1.159" "0.894" "1.192" "1.518" "1.064" "1.096" "135.5" "121.7" "162.3" "152.3" "157.1" "121.2" "161.5" "205.8" "144.1" "148.6" "" "" "" "" "" "" "" "" "" "" "127.0" "100.7" "150.6" "117.7" "133.9" "115.8" "147.5" "182.7" "144.1" "143.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5948965730676159975" "False" "Medium" "IsMasterProtein" "Q16760" "Diacylglycerol kinase delta OS=Homo sapiens OX=9606 GN=DGKD PE=1 SV=4" "0.038" "False" "1.431" "1" "1" "1" "1" "1214" "134.4" "7.56" "0.00" "1" "other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00130, Pf00169, Pf00609, Pf00781, Pf07647" "8527" "ENSG00000077044" "DGKD" "hsa:8527; Q14158; Q16760; Q6PK55; Q8NG53" "2q37 copy number variation syndrome" "Effects of PIP2 hydrolysis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4002358354751571135" "False" "Medium" "IsMasterProtein" "Q8NFP9" "Neurobeachin OS=Homo sapiens OX=9606 GN=NBEA PE=1 SV=3" "0.038" "False" "1.429" "0" "1" "1" "1" "2946" "327.6" "6.18" "1.62" "1" "other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf02138, Pf06469, Pf13385, Pf14844, Pf15787, Pf20425, Pf20426" "26960" "ENSG00000172915" "NBEA" "B7Z2H9; hsa:26960; Q5T320; Q8NFP9; Q9HCM8; Q9NSU1; Q9NW98; Q9Y6J1" "" "PKA activation; Neurotransmitter receptors and postsynaptic signal transmission; Assembly and cell surface presentation of NMDA receptors; NOTCH1 Intracellular Domain Regulates Transcription" "4" "0" "1.181" "1.279" "1.068" "1.106" "1.052" "0.994" "1.042" "0.758" "1.031" "22.8" "26.9" "29.2" "24.3" "25.2" "24.0" "22.7" "23.7" "17.3" "23.5" "" "" "" "" "" "" "" "" "" "" "21.4" "22.3" "27.1" "18.8" "21.5" "22.9" "20.7" "21.1" "17.3" "22.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7187364612041296451" "False" "Medium" "IsMasterProtein" "Q96Q05" "Trafficking protein particle complex subunit 9 OS=Homo sapiens OX=9606 GN=TRAPPC9 PE=1 SV=2" "0.039" "False" "1.422" "1" "1" "1" "1" "1148" "128.4" "6.62" "2.80" "1" "cell organization and biogenesis;transport;developmental processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf08626" "83696" "ENSG00000167632" "TRAPPC9" "hsa:83696; Q4VTT3; Q658K7; Q6P149; Q6ZQT3; Q7L5C4; Q86Y21; Q96Q05; Q96SL2; Q9BQA2" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8520642672275204077" "False" "Medium" "IsMasterProtein" "Q86YL5" "Testis development-related protein OS=Homo sapiens OX=9606 GN=TDRP PE=1 SV=2" "0.039" "False" "1.421" "8" "1" "1" "1" "185" "20.4" "6.01" "2.02" "1" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf15683" "157695" "ENSG00000180190" "TDRP" "B6VF03; B9EG53; hsa:157695; Q86YL5" "" "" "0" "0" "0.980" "0.863" "1.173" "1.029" "0.854" "1.069" "0.907" "0.839" "0.892" "102.7" "100.7" "88.6" "120.5" "105.7" "87.7" "109.8" "93.2" "86.2" "91.6" "" "" "" "" "" "" "" "" "" "" "96.3" "83.3" "82.3" "93.2" "90.1" "83.8" "100.3" "82.7" "86.2" "88.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6543857744544751788" "False" "Medium" "IsMasterProtein" "P38571" "Lysosomal acid lipase/cholesteryl ester hydrolase OS=Homo sapiens OX=9606 GN=LIPA PE=1 SV=2" "0.039" "False" "1.417" "2" "1" "2" "1" "399" "45.4" "6.92" "2.06" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00561" "3988" "ENSG00000107798" "LIPA" "B2RBH5; D3DR29; hsa:3988; P38571; Q16529; Q53H21; Q5T074; Q5T771; Q96EJ0" "Phase I biotransformations, non-P450; Degradation pathway of sphingolipids, including diseases; Cholesterol metabolism" "LDL clearance" "4" "0" "0.909" "0.950" "0.941" "0.973" "1.017" "0.938" "0.942" "0.931" "0.958" "256.1" "232.9" "243.2" "240.9" "249.2" "260.4" "240.3" "241.2" "238.4" "245.2" "" "" "" "" "" "" "" "" "" "" "240.0" "192.7" "225.8" "186.2" "212.4" "248.8" "219.5" "214.1" "238.4" "236.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "864018122010782004" "False" "Medium" "IsMasterProtein" "P35080" "Profilin-2 OS=Homo sapiens OX=9606 GN=PFN2 PE=1 SV=3" "0.039" "False" "1.415" "10" "1" "1" "1" "140" "15.0" "6.99" "0.00" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00235" "5217" "ENSG00000070087" "PFN2" "B2R4C8; D3DNI4; hsa:5217; P35080; Q4VBQ4; Q8WVF9; Q9HBK2" "Physico-chemical features and toxicity-associated pathways" "RHO GTPases Activate Formins; Signaling by ROBO receptors" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7490959433656081236" "False" "Medium" "IsMasterProtein" "P29120" "Neuroendocrine convertase 1 OS=Homo sapiens OX=9606 GN=PCSK1 PE=1 SV=2" "0.039" "False" "1.415" "2" "1" "1" "1" "753" "84.1" "5.99" "0.00" "1" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00082, Pf01483, Pf12177, Pf16470" "5122" "ENSG00000175426" "PCSK1" "B7Z8T7; E9PHA1; hsa:5122; P29120; P78478; Q92532" "Prader-Willi and Angelman syndrome; Primary ovarian insufficiency; GLP-1 secretion from intestine to portal vein; GLP-1 from intestine and pancreas and role in glucose homeostasis" "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Insulin processing; Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP); Synthesis, secretion, and deacylation of Ghrelin; Peptide hormone biosynthesis" "9" "0" "1.015" "0.930" "0.841" "0.795" "0.899" "0.868" "0.922" "0.866" "0.913" "83.6" "84.9" "77.8" "70.3" "66.5" "75.2" "72.6" "77.2" "72.4" "76.4" "" "" "" "" "" "" "" "" "" "" "78.4" "70.3" "72.2" "54.3" "56.7" "71.8" "66.4" "68.5" "72.4" "73.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5096922058442555283" "False" "Medium" "IsMasterProtein" "P0C221" "Coiled-coil domain-containing protein 175 OS=Homo sapiens OX=9606 GN=CCDC175 PE=1 SV=2" "0.039" "False" "1.414" "1" "1" "1" "1" "793" "93.6" "6.71" "0.00" "1" "" "" "" "" "729665" "ENSG00000151838" "CCDC175" "G3V5J7; hsa:729665; P0C221" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5282695994246898675" "False" "Medium" "IsMasterProtein" "O75061" "Auxilin OS=Homo sapiens OX=9606 GN=DNAJC6 PE=1 SV=3" "0.040" "False" "1.411" "1" "1" "1" "1" "913" "99.9" "7.25" "0.00" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf10409" "9829" "ENSG00000116675" "DNAJC6" "B7Z3V8; D3DQ65; D3DQ66; hsa:9829; O75061; Q32M66; Q4G0K1; Q5T614; Q5T615" "" "Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2098721597077854322" "False" "Medium" "IsMasterProtein" "Q9NTJ4" "Alpha-mannosidase 2C1 OS=Homo sapiens OX=9606 GN=MAN2C1 PE=1 SV=1" "0.041" "False" "1.409" "1" "1" "1" "1" "1040" "115.8" "6.57" "0.00" "1" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01074, Pf07748, Pf09261, Pf17677" "4123" "ENSG00000140400" "MAN2C1" "H3BMX2; H3BQY8; H3BUT6; hsa:4123; Q13358; Q68EM8; Q9NTJ4; Q9UL64" "" "Lysosomal oligosaccharide catabolism" "1" "0" "0.879" "0.894" "1.023" "0.831" "0.884" "1.020" "0.990" "0.818" "0.912" "115.7" "101.7" "103.5" "118.4" "96.2" "102.3" "118.0" "114.6" "94.6" "105.5" "" "" "" "" "" "" "" "" "" "" "108.4" "84.2" "96.0" "91.5" "82.0" "97.8" "107.8" "101.7" "94.6" "101.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4827998788629081219" "False" "Medium" "IsMasterProtein" "Q12834" "Cell division cycle protein 20 homolog OS=Homo sapiens OX=9606 GN=CDC20 PE=1 SV=2" "0.041" "False" "1.407" "2" "1" "1" "1" "499" "54.7" "9.23" "2.10" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf12894" "991" "ENSG00000117399" "CDC20" "B2R6Z6; D3DPJ1; hsa:991; Q12834; Q5JUY4; Q9BW56; Q9UQI9" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; HDAC6 interactions in the central nervous system" "Antigen processing: Ubiquitination & Proteasome degradation; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Ub-specific processing proteases; Resolution of Sister Chromatid Cohesion; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of Emi1; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; APC-Cdc20 mediated degradation of Nek2A" "23" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2649804679537679892" "False" "Medium" "IsMasterProtein" "Q9H7P9" "Pleckstrin homology domain-containing family G member 2 OS=Homo sapiens OX=9606 GN=PLEKHG2 PE=1 SV=3" "0.041" "False" "1.406" "1" "1" "1" "1" "1386" "147.9" "5.86" "1.74" "1" "cell organization and biogenesis" "cytosol" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621" "64857" "ENSG00000090924" "PLEKHG2" "B8ZZK6; C9J0Y4; hsa:64857; Q6DHV6; Q96BU2; Q96D18; Q9H699; Q9H7P9" "" "CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "4" "0" "0.864" "0.929" "0.886" "0.886" "0.946" "0.916" "0.905" "0.937" "0.966" "192.5" "166.3" "178.9" "170.5" "170.5" "182.1" "176.4" "174.2" "180.4" "185.9" "" "" "" "" "" "" "" "" "" "" "180.4" "137.6" "166.1" "131.8" "145.3" "174.0" "161.2" "154.7" "180.4" "179.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1497740122337544392" "False" "Medium" "IsMasterProtein" "Q8N3C7" "CAP-Gly domain-containing linker protein 4 OS=Homo sapiens OX=9606 GN=CLIP4 PE=1 SV=1" "0.041" "False" "1.405" "1" "1" "1" "1" "705" "76.3" "8.70" "2.40" "1" "cell organization and biogenesis" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf01302, Pf12796" "79745" "ENSG00000115295" "CLIP4" "A0AV10; B2RMQ3; B7Z7N8; hsa:79745; Q7Z4U3; Q8N3C7; Q96BR7; Q96MA5; Q9H7C0" "" "" "0" "0" "1.141" "1.122" "1.027" "1.023" "0.887" "0.845" "1.020" "0.951" "0.966" "274.7" "313.5" "308.2" "282.2" "281.1" "243.8" "232.2" "280.0" "261.3" "265.3" "" "" "" "" "" "" "" "" "" "" "257.4" "259.4" "286.1" "218.1" "239.6" "232.9" "212.2" "248.6" "261.3" "255.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3463354098168441702" "False" "Medium" "IsMasterProtein" "Q8NCY6" "Myb/SANT-like DNA-binding domain-containing protein 4 OS=Homo sapiens OX=9606 GN=MSANTD4 PE=1 SV=1" "0.041" "False" "1.405" "2" "1" "1" "1" "345" "41.1" "5.44" "2.70" "1" "" "nucleus" "" "Pf13873" "84437" "ENSG00000170903" "MSANTD4" "hsa:84437; Q8NCY6; Q96JK1; Q96JZ3; Q9H2N4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7549001655756059123" "False" "Medium" "IsMasterProtein" "Q8NFJ9" "Bardet-Biedl syndrome 1 protein OS=Homo sapiens OX=9606 GN=BBS1 PE=1 SV=1" "0.041" "False" "1.397" "1" "1" "1" "1" "593" "65.0" "7.93" "2.82" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf14779" "582" "ENSG00000174483" "BBS1" "hsa:582; Q32MM9; Q32MN0; Q8NFJ9; Q96SN4" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "BBSome-mediated cargo-targeting to cilium" "6" "0" "0.897" "0.936" "0.856" "0.876" "0.899" "0.873" "0.924" "0.803" "0.880" "537.9" "482.5" "503.3" "460.4" "471.2" "483.3" "469.5" "497.2" "431.8" "473.5" "" "" "" "" "" "" "" "" "" "" "504.0" "399.2" "467.2" "355.9" "401.7" "461.8" "429.0" "441.4" "431.8" "455.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5229500280398030060" "False" "Medium" "IsMasterProtein" "Q9Y2E5" "Epididymis-specific alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2B2 PE=1 SV=4" "0.041" "False" "1.397" "1" "1" "1" "1" "1009" "113.9" "7.24" "0.00" "1" "other metabolic processes" "other cytoplasmic organelle" "other molecular function" "Pf01074, Pf07748, Pf09261" "23324" "ENSG00000013288" "MAN2B2" "hsa:23324; Q66MP2; Q86T67; Q9Y2E5" "" "Lysosomal oligosaccharide catabolism" "1" "0" "1.276" "1.078" "1.451" "1.344" "1.083" "1.389" "1.290" "1.182" "1.181" "39.8" "50.8" "42.9" "57.8" "53.5" "43.1" "55.3" "51.3" "47.1" "47.0" "" "" "" "" "" "" "" "" "" "" "37.3" "42.0" "39.8" "44.7" "45.6" "41.2" "50.5" "45.6" "47.1" "45.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4445906156822009584" "False" "Medium" "IsMasterProtein" "Q969V3" "BOS complex subunit NCLN OS=Homo sapiens OX=9606 GN=NCLN PE=1 SV=2" "0.041" "False" "1.396" "2" "1" "1" "1" "563" "62.9" "6.89" "0.00" "1" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "translation activity" "Pf04389" "56926" "ENSG00000125912" "NCLN" "D6W613; hsa:56926; O75252; Q6FI60; Q6ZMB7; Q8TAT7; Q969V3; Q96H48; Q96IS7; Q9BQH9; Q9BTX4; Q9NPP2" "" "" "0" "0" "1.096" "1.066" "0.991" "1.148" "1.097" "1.092" "1.078" "1.155" "1.036" "100.0" "109.6" "106.6" "99.1" "114.8" "109.7" "109.2" "107.8" "115.6" "103.6" "" "" "" "" "" "" "" "" "" "" "93.7" "90.7" "99.0" "76.6" "97.8" "104.8" "99.8" "95.7" "115.6" "99.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1654139714091192156" "False" "Medium" "IsMasterProtein" "P56181" "NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV3 PE=1 SV=2" "0.041" "False" "1.392" "7" "1" "2" "1" "108" "11.9" "9.70" "3.54" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf15880" "4731" "ENSG00000160194" "NDUFV3" "A8K0M1; hsa:4731; J3KNX7; P56181; Q6FGD3; Q8WU60; Q9HCR5" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis; Mitochondrial protein degradation" "6" "0" "1.140" "1.042" "1.132" "1.073" "1.051" "1.072" "1.062" "0.972" "0.948" "165.6" "188.8" "172.5" "187.4" "177.6" "174.1" "177.5" "175.8" "161.0" "157.0" "" "" "" "" "" "" "" "" "" "" "155.1" "156.2" "160.1" "144.8" "151.4" "166.3" "162.2" "156.1" "161.0" "151.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8871411642847974399" "False" "Medium" "IsMasterProtein" "Q9H0D2" "Zinc finger protein 541 OS=Homo sapiens OX=9606 GN=ZNF541 PE=1 SV=3" "0.041" "False" "1.385" "1" "1" "1" "1" "1346" "145.5" "7.96" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00096, Pf01448, Pf13912" "84215" "ENSG00000118156" "ZNF541" "hsa:84215; Q8NDK8; Q9H0D2" "" "" "0" "0" "1.095" "1.057" "0.946" "0.989" "1.111" "1.086" "0.844" "0.988" "1.017" "191.7" "209.9" "202.5" "181.4" "189.6" "212.9" "208.2" "161.7" "189.4" "194.8" "" "" "" "" "" "" "" "" "" "" "179.6" "173.7" "188.0" "140.2" "161.6" "203.4" "190.2" "143.6" "189.4" "187.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3996932328248723017" "False" "Medium" "IsMasterProtein" "A6NLU5" "V-set and transmembrane domain-containing protein 2B OS=Homo sapiens OX=9606 GN=VSTM2B PE=1 SV=2" "0.041" "False" "1.384" "6" "1" "1" "1" "285" "30.3" "8.07" "2.63" "1" "" "other membranes" "" "Pf07686" "342865" "ENSG00000187135" "VSTM2B" "A6NLU5; hsa:342865" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9221343692610235949" "False" "Medium" "IsMasterProtein" "Q6ZUT3" "FERM domain-containing protein 7 OS=Homo sapiens OX=9606 GN=FRMD7 PE=1 SV=1" "0.041" "False" "1.382" "1" "1" "1" "1" "714" "81.6" "7.90" "0.00" "1" "developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00373, Pf08736, Pf09379, Pf09380" "90167" "ENSG00000165694" "FRMD7" "C0LLJ3; hsa:90167; Q5JX99; Q6ZUT3" "" "" "0" "0" "0.970" "0.995" "1.240" "0.926" "1.388" "1.011" "0.956" "1.081" "1.036" "128.9" "125.1" "128.3" "159.8" "119.4" "178.9" "130.3" "123.2" "139.3" "133.5" "" "" "" "" "" "" "" "" "" "" "120.8" "103.5" "119.1" "123.5" "101.8" "170.9" "119.1" "109.4" "139.3" "128.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1697211468385276031" "False" "Medium" "IsMasterProtein" "P62861" "Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein OS=Homo sapiens OX=9606 GN=FAU PE=1 SV=2" "0.042" "False" "1.379" "5" "1" "1" "1" "133" "14.4" "10.17" "2.61" "1" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00240, Pf04758" "2197" "ENSG00000149806" "FAU" "hsa:2197; P35544; P62861; Q05472; Q95261; Q9H5V4" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.364" "0.916" "0.996" "1.234" "1.081" "1.228" "1.227" "1.286" "1.169" "88.3" "120.4" "80.9" "88.0" "109.0" "95.4" "108.4" "108.3" "113.5" "103.2" "" "" "" "" "" "" "" "" "" "" "82.7" "99.6" "75.1" "68.0" "92.9" "91.2" "99.1" "96.2" "113.5" "99.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8890760883318771042" "False" "Medium" "IsMasterProtein" "Q15653" "NF-kappa-B inhibitor beta OS=Homo sapiens OX=9606 GN=NFKBIB PE=1 SV=2" "0.042" "False" "1.372" "2" "1" "1" "1" "356" "37.7" "4.84" "2.04" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00023, Pf13637" "4793" "ENSG00000104825; ENSG00000282905" "NFKBIB" "A8K3F4; hsa:4793; Q15653; Q96BJ7" "IL-1 signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-17 signaling pathway; TNF-alpha signaling pathway; Apoptosis; Novel intracellular components of RIG-I-like receptor pathway; Chemokine signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Toll-like receptor signaling pathway" "Activation of NF-kappaB in B cells; RIP-mediated NFkB activation via ZBP1; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation" "16" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8481901150612676227" "False" "Medium" "IsMasterProtein" "Q9NPH3" "Interleukin-1 receptor accessory protein OS=Homo sapiens OX=9606 GN=IL1RAP PE=1 SV=2" "0.042" "False" "1.364" "1" "1" "1" "1" "570" "65.4" "8.12" "2.44" "1" "cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01582, Pf18452" "3556" "ENSG00000196083" "IL1RAP" "B1NLD0; D3DNW0; hsa:3556; O14915; Q86WJ7; Q9NPH3" "IL-1 signaling pathway; Interleukin-1 (IL-1) structural pathway; Signal transduction through IL1R; 2q13 copy number variation syndrome" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5938288716082871535" "False" "Medium" "IsMasterProtein" "Q92753" "Nuclear receptor ROR-beta OS=Homo sapiens OX=9606 GN=RORB PE=1 SV=3" "0.043" "False" "1.357" "3" "1" "1" "1" "470" "53.2" "7.65" "0.00" "1" "developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105" "" "ENSG00000198963" "RORB" "Q8WX73; Q92753" "Clock-controlled autophagy in bone metabolism" "Nuclear Receptor transcription pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-754227750452775739" "False" "Medium" "IsMasterProtein" "Q96JI7" "Spatacsin OS=Homo sapiens OX=9606 GN=SPG11 PE=1 SV=3" "0.043" "False" "1.356" "0" "1" "1" "1" "2443" "278.7" "5.97" "2.78" "1" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf14649" "80208" "ENSG00000104133" "SPG11" "A8KAX9; B9EK60; F5H3N6; Q4VC11; Q58G86; Q69YG6; Q6NW01; Q8N270; Q8TBU9; Q96JI7; Q9H734" "" "" "0" "0" "1.344" "0.978" "1.082" "1.057" "1.107" "1.063" "0.848" "0.956" "1.087" "37.2" "50.0" "36.4" "40.3" "39.3" "41.2" "39.5" "31.5" "35.6" "40.4" "" "" "" "" "" "" "" "" "" "" "34.9" "41.4" "33.8" "31.1" "33.5" "39.3" "36.1" "28.0" "35.6" "38.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7984281592385059565" "False" "Medium" "IsMasterProtein" "Q6ZU35" "Capping protein-inhibiting regulator of actin dynamics OS=Homo sapiens OX=9606 GN=CRACD PE=1 SV=3" "0.043" "False" "1.355" "1" "1" "1" "1" "1233" "136.7" "5.60" "0.00" "1" "cell organization and biogenesis;other biological processes" "cytosol" "" "Pf15262" "57482" "ENSG00000109265" "CRACD" "hsa:57482; Q6ZU35; Q9NTE2; Q9NTP8; Q9ULK9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5043724223572356605" "False" "Medium" "IsMasterProtein" "A6H8Y1" "Transcription factor TFIIIB component B'' homolog OS=Homo sapiens OX=9606 GN=BDP1 PE=1 SV=3" "0.043" "False" "1.351" "0" "1" "1" "1" "2624" "293.7" "5.11" "2.00" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf15963" "55814" "ENSG00000145734; ENSG00000273873" "BDP1" "A6H8Y1; hsa:55814; Q68DS6; Q68DY5; Q6MZL9; Q6PIM7; Q86W98; Q96LR8; Q9C0H4; Q9H197; Q9H1A1; Q9HAW1; Q9HAW2; Q9HCY0; Q9ULH9" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter" "4" "0" "1.041" "1.072" "1.012" "1.010" "0.982" "1.060" "0.731" "0.871" "0.866" "55.5" "57.7" "59.4" "56.1" "56.0" "54.4" "58.8" "40.5" "48.3" "48.0" "" "" "" "" "" "" "" "" "" "" "52.0" "47.8" "55.2" "43.4" "47.7" "52.0" "53.7" "36.0" "48.3" "46.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5052566407640781283" "False" "Medium" "IsMasterProtein" "Q96M94" "Kelch-like protein 15 OS=Homo sapiens OX=9606 GN=KLHL15 PE=1 SV=2" "0.043" "False" "1.347" "1" "1" "1" "1" "604" "69.7" "6.40" "2.10" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00651, Pf01344, Pf07707, Pf13964" "80311" "ENSG00000174010" "KLHL15" "hsa:80311; Q32MN3; Q8NDA3; Q96BM6; Q96M94; Q9C0I6" "" "" "0" "0" "0.955" "1.216" "1.023" "1.238" "1.076" "1.072" "1.160" "1.085" "1.111" "135.1" "129.0" "164.3" "138.1" "167.2" "145.3" "144.7" "156.7" "146.6" "150.1" "" "" "" "" "" "" "" "" "" "" "126.6" "106.8" "152.5" "106.8" "142.5" "138.8" "132.3" "139.1" "146.6" "144.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7019723919198850478" "False" "Medium" "IsMasterProtein" "Q8TAX9" "Gasdermin-B OS=Homo sapiens OX=9606 GN=GSDMB PE=1 SV=3" "0.043" "False" "1.344" "3" "1" "1" "1" "416" "47.3" "5.27" "2.28" "1" "stress response;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;other molecular function" "Pf04598, Pf17708" "55876" "ENSG00000073605" "GSDMB" "B4DKK7; hsa:55876; Q7Z377; Q8TAX9; Q8WY76; Q9NX71; Q9P163" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2190798800217515771" "False" "Medium" "IsMasterProtein" "Q09428" "ATP-binding cassette sub-family C member 8 OS=Homo sapiens OX=9606 GN=ABCC8 PE=1 SV=6" "0.043" "False" "1.342" "0" "1" "1" "1" "1581" "176.9" "7.81" "2.10" "1" "cell-cell signaling;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi" "transporter activity;other molecular function" "Pf00005, Pf00664" "6833" "ENSG00000006071" "ABCC8" "A6NMX8; E3UYX6; hsa:6833; O75948; Q09428; Q16583" "" "Regulation of insulin secretion; ATP sensitive Potassium channels; Defective ABCC8 can cause hypo- and hyper-glycemias" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8812488917525874775" "False" "Medium" "IsMasterProtein" "A0AVF1" "Intraflagellar transport protein 56 OS=Homo sapiens OX=9606 GN=IFT56 PE=1 SV=1" "0.043" "False" "1.338" "1" "1" "1" "1" "554" "64.1" "6.93" "2.45" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf12895" "79989" "ENSG00000105948" "IFT56" "A0AVF1; A4D1S3; B7Z5M0; C9J2N7; F8W724; hsa:79989; Q9H9S8; Q9NTC0" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR)" "Intraflagellar transport" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3777783708088155115" "False" "Medium" "IsMasterProtein" "Q96AP0" "Adrenocortical dysplasia protein homolog OS=Homo sapiens OX=9606 GN=ACD PE=1 SV=4" "0.044" "False" "1.330" "2" "1" "1" "1" "458" "48.9" "5.30" "3.14" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10341" "65057" "ENSG00000102977" "ACD" "A0A0C4DGT6; hsa:65057; Q562H5; Q96AP0; Q9H8F9" "" "Polymerase switching on the C-strand of the telomere; Meiotic synapsis; Telomere Extension By Telomerase; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Telomere C-strand synthesis initiation; Removal of the Flap Intermediate from the C-strand" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4320196251115137643" "False" "Medium" "IsMasterProtein" "O43405" "Cochlin OS=Homo sapiens OX=9606 GN=COCH PE=1 SV=1" "0.044" "False" "1.327" "1" "1" "2" "1" "550" "59.4" "7.96" "0.00" "1" "other biological processes" "non-structural extracellular;extracellular matrix" "other molecular function" "Pf00092, Pf03815" "1690" "ENSG00000100473" "COCH" "A8K9K9; D3DS84; hsa:1690; O43405; Q96IU6" "" "" "0" "0" "0.958" "0.996" "1.192" "1.112" "1.034" "0.972" "1.063" "0.948" "1.097" "73.8" "70.7" "73.5" "88.0" "82.1" "76.3" "71.7" "78.5" "70.0" "81.0" "" "" "" "" "" "" "" "" "" "" "69.2" "58.5" "68.3" "68.0" "70.0" "72.9" "65.5" "69.7" "70.0" "78.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3107589471447250441" "False" "Medium" "IsMasterProtein" "Q9NV06" "DDB1- and CUL4-associated factor 13 OS=Homo sapiens OX=9606 GN=DCAF13 PE=1 SV=2" "0.044" "False" "1.326" "2" "1" "1" "1" "445" "51.4" "9.19" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400, Pf04158, Pf08662" "25879" "ENSG00000164934" "DCAF13" "hsa:25879; Q3MII9; Q8NCH8; Q8TC51; Q96JY7; Q9NV06; Q9NZX3" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Neddylation" "3" "0" "1.000" "1.059" "1.190" "1.155" "1.118" "1.167" "1.041" "1.122" "1.024" "72.1" "72.1" "76.4" "85.8" "83.3" "80.6" "84.2" "75.1" "80.9" "73.8" "" "" "" "" "" "" "" "" "" "" "67.6" "59.7" "70.9" "66.3" "71.0" "77.0" "76.9" "66.7" "80.9" "71.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4319131139197179566" "False" "Medium" "IsMasterProtein" "Q9UHF7" "Zinc finger transcription factor Trps1 OS=Homo sapiens OX=9606 GN=TRPS1 PE=1 SV=2" "0.044" "False" "1.324" "1" "1" "1" "1" "1281" "141.4" "7.58" "0.00" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00320" "7227" "ENSG00000104447" "TRPS1" "B4E1Z5; hsa:7227; Q08AU2; Q9NWE1; Q9UHF7; Q9UHH6" "" "" "0" "0" "1.334" "1.110" "1.357" "1.241" "1.050" "1.311" "1.029" "1.206" "1.061" "33.8" "45.1" "37.5" "45.9" "41.9" "35.5" "44.3" "34.8" "40.8" "35.9" "" "" "" "" "" "" "" "" "" "" "31.7" "37.3" "34.8" "35.5" "35.7" "33.9" "40.5" "30.9" "40.8" "34.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5097658218394758056" "False" "Medium" "IsMasterProtein" "P54259" "Atrophin-1 OS=Homo sapiens OX=9606 GN=ATN1 PE=1 SV=3" "0.044" "False" "1.322" "1" "1" "1" "1" "1190" "125.3" "8.98" "2.51" "1" "developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03154" "1822" "ENSG00000111676" "ATN1" "hsa:1822; P54259; Q99495; Q99621; Q9UEK7" "" "Regulation of PTEN gene transcription" "1" "0" "0.977" "0.922" "0.938" "0.848" "0.882" "0.856" "0.881" "1.104" "0.962" "773.9" "756.3" "713.3" "726.2" "656.3" "682.9" "662.2" "682.0" "854.0" "744.5" "" "" "" "" "" "" "" "" "" "" "725.1" "625.8" "662.2" "561.4" "559.4" "652.4" "605.1" "605.5" "854.0" "716.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4102789936639364292" "False" "Medium" "IsMasterProtein" "Q9NPP4" "NLR family CARD domain-containing protein 4 OS=Homo sapiens OX=9606 GN=NLRC4 PE=1 SV=2" "0.044" "False" "1.320" "1" "1" "1" "1" "1024" "116.1" "6.77" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf05729, Pf17889" "58484" "ENSG00000091106" "NLRC4" "A8K9F8; B2RBQ3; B3KTF0; D6W580; hsa:58484; Q96J81; Q96J82; Q96J83; Q9NPP4" "Nucleotide-binding oligomerization domain (NOD) pathway" "TP53 Regulates Transcription of Caspase Activators and Caspases; The IPAF inflammasome" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8495950413503978774" "False" "Medium" "IsMasterProtein" "O15327" "Inositol polyphosphate 4-phosphatase type II OS=Homo sapiens OX=9606 GN=INPP4B PE=1 SV=4" "0.044" "False" "1.319" "1" "1" "1" "1" "924" "104.7" "6.27" "2.19" "1" "other metabolic processes;signal transduction" "cytosol;other cell component" "other molecular function" "" "8821" "ENSG00000109452" "INPP4B" "hsa:8821; O15327; Q2TAI2; Q5XLE7; Q6IN59; Q6PJB4" "VEGFA-VEGFR2 signaling" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of IP2, IP, and Ins in the cytosol" "4" "0" "0.986" "0.853" "1.772" "1.118" "0.889" "1.227" "0.986" "0.771" "0.887" "119.3" "117.6" "101.7" "211.3" "133.4" "106.0" "146.3" "117.6" "91.9" "105.8" "" "" "" "" "" "" "" "" "" "" "111.7" "97.3" "94.4" "163.4" "113.7" "101.3" "133.7" "104.5" "91.9" "101.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5479950461840362459" "False" "Medium" "IsMasterProtein" "Q0VGL1" "Ragulator complex protein LAMTOR4 OS=Homo sapiens OX=9606 GN=LAMTOR4 PE=1 SV=1" "0.045" "False" "1.314" "7" "1" "1" "1" "99" "10.7" "6.54" "1.72" "1" "cell organization and biogenesis;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "" "389541" "ENSG00000188186" "LAMTOR4" "hsa:389541; Q0VGL1" "" "TP53 Regulates Metabolic Genes; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "7" "0" "0.935" "1.025" "1.038" "1.007" "1.009" "1.048" "0.959" "0.927" "1.029" "246.9" "230.7" "253.0" "256.2" "248.6" "249.2" "258.7" "236.6" "228.9" "254.1" "" "" "" "" "" "" "" "" "" "" "231.3" "190.9" "234.9" "198.1" "211.9" "238.1" "236.4" "210.1" "228.9" "244.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-140243199902963868" "False" "Medium" "IsMasterProtein" "Q13835" "Plakophilin-1 OS=Homo sapiens OX=9606 GN=PKP1 PE=1 SV=2" "0.045" "False" "1.313" "1" "1" "2" "1" "747" "82.8" "9.13" "0.00" "1" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00514" "5317" "ENSG00000081277" "PKP1" "hsa:5317; O00645; Q13835; Q14CA0; Q15152" "Epithelial to mesenchymal transition in colorectal cancer" "Neutrophil degranulation; Formation of the cornified envelope; Apoptotic cleavage of cell adhesion proteins" "5" "0" "0.969" "0.980" "1.062" "1.080" "1.040" "1.053" "0.819" "0.833" "0.919" "151.3" "146.6" "148.3" "160.8" "163.4" "157.3" "159.3" "123.9" "126.0" "139.0" "" "" "" "" "" "" "" "" "" "" "141.8" "121.3" "137.7" "124.3" "139.3" "150.3" "145.6" "110.0" "126.0" "133.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3340438391070150968" "False" "Medium" "IsMasterProtein" "Q5SZD1" "Uncharacterized protein C6orf141 OS=Homo sapiens OX=9606 GN=C6orf141 PE=1 SV=3" "0.045" "False" "1.311" "3" "1" "1" "1" "244" "26.7" "8.54" "2.06" "1" "" "" "" "" "135398" "ENSG00000197261" "C6orf141" "A8K1H4; hsa:135398; Q5SZD1; Q8N400; Q96NQ1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1070093787399914439" "False" "Medium" "IsMasterProtein" "Q5T5U3" "Rho GTPase-activating protein 21 OS=Homo sapiens OX=9606 GN=ARHGAP21 PE=1 SV=2" "0.045" "False" "1.311" "1" "1" "1" "1" "1958" "217.3" "7.80" "0.00" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00169, Pf00620, Pf17820" "57584" "ENSG00000107863" "ARHGAP21" "hsa:57584; Q0VF98; Q5T5U3; Q7Z3P7; Q8N3A2; Q8NI19; Q8TBV5; Q9P2C3" "" "RHOD GTPase cycle; RHOF GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RND3 GTPase cycle" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-808738140412640069" "False" "Medium" "IsMasterProtein" "Q8N807" "Protein disulfide-isomerase-like protein of the testis OS=Homo sapiens OX=9606 GN=PDILT PE=1 SV=2" "0.045" "False" "1.309" "2" "1" "1" "1" "584" "66.6" "6.86" "0.00" "1" "protein metabolism;other metabolic processes;other biological processes" "ER/Golgi" "other molecular function" "Pf00085, Pf13848" "204474" "ENSG00000169340" "PDILT" "hsa:204474; Q8IVQ5; Q8N807" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6360176631635833399" "False" "Medium" "IsMasterProtein" "P25054" "Adenomatous polyposis coli protein OS=Homo sapiens OX=9606 GN=APC PE=1 SV=2" "0.045" "False" "1.309" "0" "1" "1" "1" "2843" "311.5" "7.80" "1.67" "1" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00514, Pf05923, Pf05924, Pf05937, Pf05956, Pf05972, Pf11414, Pf16629, Pf16630, Pf16633, Pf16634, Pf16635, Pf16636, Pf16689, Pf18797" "324" "ENSG00000134982" "APC" "B7Z2B6; D3DT03; hsa:324; P25054; Q15162; Q15163; Q93042" "Microtubule cytoskeleton regulation; Alzheimer's disease and miRNA effects; Gastric cancer network 1; Brain-derived neurotrophic factor (BDNF) signaling pathway; Endoderm differentiation; Extracellular vesicle-mediated signaling in recipient cells; Copper homeostasis; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Regulation of sister chromatid separation at the metaphase-anaphase transition; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Cohesin complex - Cornelia de Lange syndrome; Alzheimer's disease; 2q21.1 copy number variation syndrome; HDAC6 interactions in the central nervous system; DNA damage response (only ATM dependent)" "Deactivation of the beta-catenin transactivating complex; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Ovarian tumor domain proteases; Apoptotic cleavage of cellular proteins; APC truncation mutants are not K63 polyubiquitinated" "45" "0" "0.968" "0.940" "1.023" "0.966" "0.983" "0.937" "0.886" "0.875" "0.920" "109.7" "106.2" "103.1" "112.2" "105.9" "107.8" "102.8" "97.2" "95.9" "100.9" "" "" "" "" "" "" "" "" "" "" "102.8" "87.9" "95.7" "86.8" "90.3" "103.0" "93.9" "86.3" "95.9" "97.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8888503274832320962" "False" "Medium" "IsMasterProtein" "P17038" "Zinc finger protein 43 OS=Homo sapiens OX=9606 GN=ZNF43 PE=1 SV=4" "0.045" "False" "1.309" "1" "1" "1" "1" "809" "94.1" "9.19" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352, Pf13912" "7594" "ENSG00000198521" "ZNF43" "A8K5N8; hsa:7594; P17038; P28160; Q53XQ2; Q5H9T3; Q96DG1" "" "Generic Transcription Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7890982499762508055" "False" "Medium" "IsMasterProtein" "O75689" "Arf-GAP with dual PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ADAP1 PE=1 SV=2" "0.045" "False" "1.308" "2" "1" "1" "1" "374" "43.4" "8.97" "0.00" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01412" "11033" "ENSG00000105963" "ADAP1" "A4D2Q2; B3KRZ4; B4DVA6; F6XZ68; H7C2Q4; hsa:11033; O75689" "" "Nuclear signaling by ERBB4" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6366471573816439068" "False" "Medium" "IsMasterProtein" "P52179" "Myomesin-1 OS=Homo sapiens OX=9606 GN=MYOM1 PE=1 SV=2" "0.045" "False" "1.308" "1" "1" "1" "1" "1685" "187.5" "6.93" "1.71" "1" "developmental processes;signal transduction;other biological processes" "cytoskeleton" "other molecular function" "Pf00041, Pf07679" "8736" "ENSG00000101605" "MYOM1" "hsa:8736; P52179; Q14BD6; Q6H969; Q6ZUU0" "Striated muscle contraction pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5872351769456047706" "False" "Medium" "IsMasterProtein" "Q9NPC4" "Lactosylceramide 4-alpha-galactosyltransferase OS=Homo sapiens OX=9606 GN=A4GALT PE=1 SV=1" "0.046" "False" "1.303" "4" "1" "1" "1" "353" "40.5" "8.95" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf04488, Pf04572" "53947" "ENSG00000128274" "A4GALT" "B2R7C4; hsa:53947; Q9NPC4; Q9P1X5" "Synthesis of ceramides and 1-deoxyceramides" "Glycosphingolipid biosynthesis" "2" "0" "1.122" "1.016" "1.179" "1.116" "1.101" "1.128" "1.087" "1.022" "1.093" "75.8" "85.0" "76.9" "89.3" "84.5" "83.4" "85.5" "82.4" "77.4" "82.8" "" "" "" "" "" "" "" "" "" "" "71.0" "70.3" "71.4" "69.0" "72.1" "79.7" "78.1" "73.1" "77.4" "79.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2621358434060529142" "False" "Medium" "IsMasterProtein" "P57058" "Hormonally up-regulated neu tumor-associated kinase OS=Homo sapiens OX=9606 GN=HUNK PE=1 SV=1" "0.046" "False" "1.302" "1" "1" "1" "1" "714" "79.6" "9.13" "2.34" "1" "other metabolic processes;signal transduction" "other cell component" "kinase activity;other molecular function" "Pf00069" "30811" "ENSG00000142149" "HUNK" "hsa:30811; P57058" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5976996630127458514" "False" "Medium" "IsMasterProtein" "O75815" "Breast cancer anti-estrogen resistance protein 3 OS=Homo sapiens OX=9606 GN=BCAR3 PE=1 SV=1" "0.046" "False" "1.301" "1" "1" "1" "1" "825" "92.5" "7.96" "2.37" "1" "developmental processes;signal transduction;other biological processes" "other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00017, Pf00617" "8412" "ENSG00000137936" "BCAR3" "D3DT43; hsa:8412; O75815; Q5TEW3; Q6UW40; Q9BR50" "" "" "0" "0" "1.001" "0.798" "1.103" "0.916" "0.979" "0.953" "0.773" "0.905" "1.098" "60.4" "60.5" "48.2" "66.6" "55.3" "59.1" "57.6" "46.7" "54.7" "66.3" "" "" "" "" "" "" "" "" "" "" "56.6" "50.0" "44.7" "51.5" "47.2" "56.5" "52.6" "41.4" "54.7" "63.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5828949100496623215" "False" "Medium" "IsMasterProtein" "Q92844" "TRAF family member-associated NF-kappa-B activator OS=Homo sapiens OX=9606 GN=TANK PE=1 SV=2" "0.046" "False" "1.298" "2" "1" "1" "1" "425" "47.8" "5.68" "2.09" "1" "stress response;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf12845" "10010" "ENSG00000136560" "TANK" "D3DPB5; hsa:10010; Q7Z4J6; Q92844; Q92885" "TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Novel intracellular components of RIG-I-like receptor pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "Activation of IRF3, IRF7 mediated by TBK1, IKBKE; TICAM1-dependent activation of IRF3/IRF7; TRAF6 mediated IRF7 activation" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6803060503545767459" "False" "Medium" "IsMasterProtein" "Q8NDX6" "Zinc finger protein 740 OS=Homo sapiens OX=9606 GN=ZNF740 PE=1 SV=1" "0.046" "False" "1.297" "4" "1" "1" "1" "193" "21.8" "9.19" "2.13" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "283337" "ENSG00000139651" "ZNF740" "A8K9M9; hsa:283337; Q8NDX6" "" "Generic Transcription Pathway" "1" "0" "1.135" "1.022" "1.261" "1.079" "1.066" "1.177" "1.104" "1.031" "1.194" "63.3" "71.8" "64.7" "79.8" "68.3" "67.5" "74.5" "69.9" "65.3" "75.6" "" "" "" "" "" "" "" "" "" "" "59.3" "59.5" "60.0" "61.7" "58.2" "64.5" "68.1" "62.1" "65.3" "72.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6784798439083534875" "False" "Medium" "IsMasterProtein" "Q9NZQ0" "DnaJ homolog subfamily C member 27 OS=Homo sapiens OX=9606 GN=DNAJC27 PE=1 SV=1" "0.047" "False" "1.295" "4" "1" "1" "1" "273" "30.8" "8.46" "0.00" "1" "transport;other biological processes" "nucleus" "other molecular function" "Pf00071, Pf00226" "51277" "ENSG00000115137" "DNAJC27" "hsa:51277; Q5JV88; Q86Y24; Q9NZQ0" "" "" "0" "0" "1.040" "0.965" "1.134" "1.163" "1.129" "1.002" "1.177" "1.015" "0.970" "88.2" "91.8" "85.2" "100.1" "102.6" "99.6" "88.4" "103.9" "89.5" "85.6" "" "" "" "" "" "" "" "" "" "" "82.7" "75.9" "79.1" "77.4" "87.5" "95.2" "80.8" "92.2" "89.5" "82.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2748783261369810529" "False" "Medium" "IsMasterProtein" "P11182" "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DBT PE=1 SV=4" "0.047" "False" "1.291" "2" "1" "1" "1" "482" "53.5" "8.51" "1.84" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "0.988" "1.016" "1.263" "1.071" "1.084" "1.122" "1.099" "1.106" "1.095" "158.2" "156.3" "160.7" "199.8" "169.5" "171.5" "177.4" "173.9" "174.9" "173.3" "" "" "" "" "" "" "" "" "" "" "148.2" "129.4" "149.2" "154.4" "144.5" "163.9" "162.1" "154.4" "174.9" "166.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8980978827116582562" "False" "Medium" "IsMasterProtein" "Q07889" "Son of sevenless homolog 1 OS=Homo sapiens OX=9606 GN=SOS1 PE=1 SV=1" "0.047" "False" "1.289" "1" "1" "1" "1" "1333" "152.4" "6.84" "0.00" "1" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00169, Pf00617, Pf00618, Pf00621" "6654" "ENSG00000115904" "SOS1" "A8K2G3; B4DXG2; hsa:6654; Q07889" "IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; Pilocytic astrocytoma; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; Oncostatin M signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Acute viral myocarditis; Thermogenesis; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; Regulation of actin cytoskeleton; Acute myeloid leukemia; 4p16.3 copy number variation; 5q35 copy number variation; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "RAC1 GTPase cycle; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; NRAGE signals death through JNK; G alpha (12/13) signalling events; RET signaling; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Regulation of KIT signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; Signaling by CSF1 (M-CSF) in myeloid cells; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 in disease; Activated NTRK2 signals through FRS2 and FRS3; Activation of RAC1; Erythropoietin activates RAS; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; Signalling to RAS; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MET activates RAS signaling; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; Signal attenuation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Interleukin-15 signaling" "120" "0" "1.151" "1.085" "1.148" "1.017" "1.112" "1.026" "1.089" "1.236" "1.078" "109.5" "126.1" "118.8" "125.8" "111.4" "121.9" "112.4" "119.3" "135.4" "118.1" "" "" "" "" "" "" "" "" "" "" "102.6" "104.3" "110.3" "97.2" "95.0" "116.4" "102.7" "105.9" "135.4" "113.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8273844760254515053" "False" "Medium" "IsMasterProtein" "Q96QE3" "ATPase family AAA domain-containing protein 5 OS=Homo sapiens OX=9606 GN=ATAD5 PE=1 SV=4" "0.048" "False" "1.287" "1" "1" "1" "1" "1844" "207.4" "9.19" "3.38" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004" "79915" "ENSG00000176208" "ATAD5" "hsa:79915; Q05DH0; Q69YR6; Q96QE3; Q9H9I1" "NF1 copy number variation syndrome" "" "1" "0" "1.015" "0.981" "1.107" "1.102" "1.011" "0.988" "1.027" "1.110" "1.081" "143.8" "146.0" "141.1" "159.2" "158.5" "145.3" "142.1" "147.7" "159.6" "155.5" "" "" "" "" "" "" "" "" "" "" "134.8" "120.8" "131.0" "123.1" "135.1" "138.9" "129.8" "131.2" "159.6" "149.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2069331310574252297" "False" "Medium" "IsMasterProtein" "O43708" "Maleylacetoacetate isomerase OS=Homo sapiens OX=9606 GN=GSTZ1 PE=1 SV=3" "0.048" "False" "1.285" "4" "1" "1" "1" "216" "24.2" "8.54" "3.86" "1" "other metabolic processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf13409, Pf14497" "2954" "ENSG00000100577" "GSTZ1" "A6NED0; A6NNB8; A8MWD7; B2RCK3; hsa:2954; O15308; O43708; O75430; Q6IB17; Q7Z610; Q9BV63" "Metapathway biotransformation Phase I and II" "Regulation of pyruvate dehydrogenase (PDH) complex; Glutathione conjugation; Tyrosine catabolism" "4" "0" "0.984" "0.989" "0.945" "0.996" "0.951" "0.986" "0.937" "0.964" "0.946" "296.9" "292.3" "293.6" "280.6" "295.8" "282.3" "292.7" "278.1" "286.4" "280.9" "" "" "" "" "" "" "" "" "" "" "278.2" "241.9" "272.6" "216.9" "252.1" "269.7" "267.4" "246.9" "286.4" "270.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6361310259065089724" "False" "Medium" "IsMasterProtein" "O75473" "Leucine-rich repeat-containing G-protein coupled receptor 5 OS=Homo sapiens OX=9606 GN=LGR5 PE=1 SV=1" "0.048" "False" "1.279" "1" "1" "2" "1" "907" "99.9" "6.60" "4.69" "1" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus" "other molecular function" "Pf00001, Pf01462, Pf12799, Pf13855" "8549" "ENSG00000139292" "LGR5" "D8MCT0; hsa:8549; O75473; Q4VAM0; Q4VAM2; Q9UP75" "" "Regulation of FZD by ubiquitination" "1" "0" "0.578" "1.003" "0.915" "0.898" "0.881" "1.632" "0.942" "0.687" "0.941" "219.5" "126.9" "220.2" "200.8" "197.2" "193.4" "358.3" "206.9" "150.9" "206.6" "" "" "" "" "" "" "" "" "" "" "205.7" "105.0" "204.4" "155.3" "168.1" "184.8" "327.4" "183.7" "150.9" "198.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3580192836813559225" "False" "Medium" "IsMasterProtein" "O95425" "Supervillin OS=Homo sapiens OX=9606 GN=SVIL PE=1 SV=2" "0.048" "False" "1.278" "1" "1" "1" "1" "2214" "247.6" "6.98" "0.00" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00626, Pf02209" "6840" "ENSG00000197321" "SVIL" "D3DRW9; hsa:6840; M1J557; O60611; O60612; O95425; Q5VZK5; Q5VZK6; Q9H1R7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6338677437993936073" "False" "Medium" "IsMasterProtein" "P30305" "M-phase inducer phosphatase 2 OS=Homo sapiens OX=9606 GN=CDC25B PE=1 SV=2" "0.048" "False" "1.278" "1" "1" "1" "1" "580" "64.9" "6.40" "2.27" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00581, Pf06617" "994" "ENSG00000101224" "CDC25B" "D3DVY1; D3DVY2; D3DVY3; D3DVY4; hsa:994; O43551; P30305; Q13971; Q5JX77; Q6RSS1; Q9BRA6" "Cell cycle; Integrated cancer pathway; Androgen receptor network in prostate cancer; Retinoblastoma gene in cancer; MAPK signaling pathway" "Cyclin A/B1/B2 associated events during G2/M transition; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Cyclin A:Cdk2-associated events at S phase entry" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7426344905124172545" "False" "Medium" "IsMasterProtein" "Q9BR61" "Acyl-CoA-binding domain-containing protein 6 OS=Homo sapiens OX=9606 GN=ACBD6 PE=1 SV=1" "0.048" "False" "1.274" "3" "1" "1" "1" "282" "31.1" "5.11" "2.77" "1" "" "cytosol" "other molecular function" "Pf00887, Pf12796" "84320" "ENSG00000230124" "ACBD6" "hsa:84320; Q9BR61" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3405568323985279631" "False" "Medium" "IsMasterProtein" "Q13214" "Semaphorin-3B OS=Homo sapiens OX=9606 GN=SEMA3B PE=1 SV=1" "0.049" "False" "1.271" "3" "1" "1" "1" "749" "83.1" "8.91" "0.00" "1" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;ER/Golgi" "signal transduction activity or receptor binding" "Pf00047, Pf01403" "7869" "ENSG00000012171" "SEMA3B" "hsa:7869; Q13214; Q6GU46; Q8TB71; Q8TDV7; Q93018; Q96GX0" "Vitamin D receptor pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3631666065222226929" "False" "Medium" "IsMasterProtein" "P42898" "Methylenetetrahydrofolate reductase (NADPH) OS=Homo sapiens OX=9606 GN=MTHFR PE=1 SV=3" "0.049" "False" "1.270" "1" "1" "1" "1" "656" "74.5" "5.34" "2.23" "1" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf02219" "4524" "ENSG00000177000" "MTHFR" "B2R7A6; hsa:4524; P42898; Q5SNW6; Q5SNW9; Q7Z6M6; Q8IU73; Q9UQR2" "Glycine metabolism; Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; MTHFR deficiency; Male infertility; Spina bifida" "Metabolism of folate and pterines" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3417396433286525130" "False" "Medium" "IsMasterProtein" "Q59H18" "Serine/threonine-protein kinase TNNI3K OS=Homo sapiens OX=9606 GN=TNNI3K PE=1 SV=3" "0.049" "False" "1.267" "1" "1" "1" "1" "835" "92.8" "6.74" "2.38" "1" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf07714, Pf12796" "100526835; 51086" "ENSG00000116783" "TNNI3K" "hsa:100526835; hsa:51086; Q17RN0; Q49AR1; Q59H18; Q6MZS9; Q9Y2V6" "" "" "0" "0" "0.878" "0.870" "0.968" "0.904" "0.867" "0.889" "0.891" "0.974" "0.882" "210.0" "184.2" "182.6" "203.1" "189.9" "182.1" "186.7" "187.1" "204.5" "185.2" "" "" "" "" "" "" "" "" "" "" "196.7" "152.5" "169.5" "157.0" "161.9" "174.0" "170.6" "166.1" "204.5" "178.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5326336866733362135" "False" "Medium" "IsMasterProtein" "P17031" "Zinc finger protein 26 OS=Homo sapiens OX=9606 GN=ZNF26 PE=1 SV=3" "0.049" "False" "1.265" "2" "1" "1" "1" "533" "61.2" "8.84" "2.04" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "7574" "ENSG00000198393" "ZNF26" "hsa:7574; P17031; Q86X57; Q9NWL3" "" "Generic Transcription Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7998803264770507825" "False" "Medium" "IsMasterProtein" "Q96JB1" "Dynein axonemal heavy chain 8 OS=Homo sapiens OX=9606 GN=DNAH8 PE=1 SV=2" "0.050" "False" "1.260" "0" "1" "1" "1" "4490" "514.3" "6.32" "2.11" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton" "cytoskeletal activity;other molecular function" "Pf03028, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf17852, Pf17857, Pf18198, Pf18199" "1769" "ENSG00000124721" "DNAH8" "hsa:1769; O00438; Q5JYI2; Q5T2M3; Q5T2M4; Q5TG00; Q96JB1; Q9UEM4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8311672311876530303" "False" "Low" "IsMasterProtein" "Q8IY63" "Angiomotin-like protein 1 OS=Homo sapiens OX=9606 GN=AMOTL1 PE=1 SV=1" "0.050" "False" "1.256" "1" "1" "1" "1" "956" "106.5" "7.11" "2.28" "1" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf12240" "154810" "ENSG00000166025" "AMOTL1" "hsa:154810; Q63HK7; Q8IY63; Q8NDN0; Q8TEN8; Q8WXD1; Q96CM5" "" "Signaling by Hippo" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7873984446358378188" "False" "Low" "IsMasterProtein" "Q6UUV9" "CREB-regulated transcription coactivator 1 OS=Homo sapiens OX=9606 GN=CRTC1 PE=1 SV=2" "0.050" "False" "1.254" "1" "1" "1" "1" "634" "67.3" "6.05" "0.00" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12884, Pf12885, Pf12886" "23373" "ENSG00000105662" "CRTC1" "A6NMG5; hsa:23373; O75114; Q6UUV9; Q6Y3A3; Q7LDZ2; Q8IUL3; Q8IZ34; Q8IZL1; Q8N6W3; Q96AI8; Q9H801" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Mesodermal commitment pathway" "Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1954623923501006519" "False" "Low" "IsMasterProtein" "Q8TBE9" "N-acylneuraminate-9-phosphatase OS=Homo sapiens OX=9606 GN=NANP PE=1 SV=1" "0.050" "False" "1.253" "3" "1" "1" "1" "248" "27.8" "6.40" "1.81" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf00702" "140838" "ENSG00000170191" "NANP" "B3KP12; hsa:140838; Q5JYN8; Q8TBE9; Q8TE97; Q9Y3N0" "" "Sialic acid metabolism" "1" "0" "1.166" "1.191" "1.263" "1.169" "1.043" "1.253" "1.149" "1.138" "1.104" "304.7" "355.2" "362.9" "384.9" "356.2" "317.9" "382.0" "350.3" "346.8" "336.3" "" "" "" "" "" "" "" "" "" "" "285.5" "293.9" "336.9" "297.6" "303.6" "303.7" "349.0" "311.0" "346.8" "323.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4925255109187835280" "False" "Low" "IsMasterProtein" "O95872" "G patch domain and ankyrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GPANK1 PE=1 SV=1" "0.050" "False" "1.252" "2" "1" "1" "1" "356" "39.3" "8.19" "2.25" "1" "" "" "nucleic acid binding activity" "Pf01585, Pf13637" "7918" "ENSG00000204438; ENSG00000206408; ENSG00000223932; ENSG00000228605; ENSG00000232312; ENSG00000236011" "GPANK1" "A6NG25; B0UXA2; hsa:7918; O95872; Q5SQ49" "" "" "0" "0" "1.071" "0.978" "1.001" "1.048" "1.103" "1.070" "1.008" "0.941" "1.053" "87.0" "93.1" "85.1" "87.0" "91.1" "95.9" "93.0" "87.6" "81.8" "91.6" "" "" "" "" "" "" "" "" "" "" "81.5" "77.1" "79.0" "67.3" "77.7" "91.7" "85.0" "77.8" "81.8" "88.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1288409526495394061" "False" "Low" "IsMasterProtein" "Q02383" "Semenogelin-2 OS=Homo sapiens OX=9606 GN=SEMG2 PE=1 SV=1" "0.050" "False" "1.252" "1" "1" "1" "1" "582" "65.4" "9.07" "0.00" "1" "stress response;other biological processes" "non-structural extracellular" "other molecular function" "Pf05474" "6407" "ENSG00000124157" "SEMG2" "hsa:6407; Q02383; Q53ZU2; Q6X2M5; Q6X2M6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8144143773701593515" "False" "Low" "IsMasterProtein" "Q8IZT6" "Abnormal spindle-like microcephaly-associated protein OS=Homo sapiens OX=9606 GN=ASPM PE=1 SV=2" "0.051" "False" "1.246" "0" "1" "1" "1" "3477" "409.5" "10.45" "1.77" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00307, Pf00612, Pf15780" "259266" "ENSG00000066279" "ASPM" "hsa:259266; Q4G1H1; Q5VYL3; Q86UX4; Q8IUL2; Q8IZJ7; Q8IZJ8; Q8IZJ9; Q8IZT6; Q8N4D1; Q9NVS1; Q9NVT6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7789640174005982269" "False" "Low" "IsMasterProtein" "Q9Y5R2" "Matrix metalloproteinase-24 OS=Homo sapiens OX=9606 GN=MMP24 PE=1 SV=1" "0.051" "False" "1.244" "2" "1" "1" "1" "645" "73.2" "9.23" "2.59" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00045, Pf00413, Pf01471, Pf11857" "10893" "ENSG00000125966" "MMP24" "B7ZBG8; hsa:10893; Q9H440; Q9Y5R2" "Matrix metalloproteinases; Chronic hyperglycemia impairment of neuron function" "Activation of Matrix Metalloproteinases" "3" "0" "0.902" "0.952" "1.104" "0.918" "0.891" "0.997" "0.859" "0.953" "1.062" "109.9" "99.2" "104.7" "121.4" "101.0" "98.0" "109.6" "94.5" "104.8" "116.8" "" "" "" "" "" "" "" "" "" "" "103.0" "82.1" "97.2" "93.8" "86.1" "93.6" "100.1" "83.9" "104.8" "112.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2869941848494998165" "False" "Low" "IsMasterProtein" "O75170" "Serine/threonine-protein phosphatase 6 regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PPP6R2 PE=1 SV=2" "0.051" "False" "1.243" "1" "1" "1" "1" "966" "104.9" "4.87" "2.57" "1" "" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04499" "9701" "ENSG00000100239" "PPP6R2" "A6PVG3; B7Z7T3; hsa:9701; O75170; Q5U5P3; Q7Z2L2; Q7Z5G5; Q7Z731; Q9UGB9" "" "" "0" "0" "1.085" "0.977" "1.125" "1.036" "0.998" "1.035" "0.970" "0.916" "0.961" "227.0" "246.3" "221.8" "255.5" "235.2" "226.6" "234.9" "220.3" "207.9" "218.1" "" "" "" "" "" "" "" "" "" "" "212.7" "203.8" "205.9" "197.5" "200.4" "216.5" "214.6" "195.6" "207.9" "210.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6346286157206717868" "False" "Low" "IsMasterProtein" "Q8IVV2" "Lipoxygenase homology domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LOXHD1 PE=2 SV=4" "0.051" "False" "1.242" "0" "1" "1" "1" "2067" "235.5" "5.57" "2.24" "1" "other biological processes" "other cell component" "" "Pf01477" "125336" "ENSG00000167210" "LOXHD1" "B7WNN3; B7WNT1; B7WPI9; H7BZ41; hsa:125336; Q6ZRY7; Q86WW9; Q8IVV2; Q96DL7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7814237526042279492" "False" "Low" "IsMasterProtein" "Q5H9E4" "Solute carrier family 25 member 53 OS=Homo sapiens OX=9606 GN=SLC25A53 PE=1 SV=1" "0.052" "False" "1.238" "4" "1" "1" "1" "307" "34.5" "9.85" "0.00" "1" "transport" "other membranes;mitochondrion" "transporter activity" "Pf00153" "401612" "ENSG00000269743" "SLC25A53" "B2RTT9; hsa:401612; Q5H9E4" "" "" "0" "0" "1.152" "1.111" "1.225" "1.242" "1.172" "1.187" "1.273" "1.318" "1.211" "76.4" "88.1" "84.9" "93.7" "94.9" "89.6" "90.7" "97.3" "100.7" "92.6" "" "" "" "" "" "" "" "" "" "" "71.6" "72.9" "78.8" "72.4" "80.9" "85.6" "82.9" "86.4" "100.7" "89.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4316199333645663287" "False" "Low" "IsMasterProtein" "Q9NPG3" "Ubinuclein-1 OS=Homo sapiens OX=9606 GN=UBN1 PE=1 SV=2" "0.052" "False" "1.237" "1" "1" "1" "1" "1134" "121.4" "9.33" "2.40" "1" "cell organization and biogenesis" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf08729, Pf14075" "29855" "ENSG00000118900" "UBN1" "B7Z6D3; D3DUE8; hsa:29855; Q13079; Q9NPG3; Q9P1P7" "15q11q13 copy number variation" "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1877378718516285483" "False" "Low" "IsMasterProtein" "Q9BYJ1" "Hydroperoxide isomerase ALOXE3 OS=Homo sapiens OX=9606 GN=ALOXE3 PE=1 SV=1" "0.052" "False" "1.236" "1" "1" "1" "1" "711" "80.5" "6.96" "1.84" "1" "other metabolic processes;signal transduction;other biological processes" "cytosol" "other molecular function" "Pf00305, Pf01477" "59344" "ENSG00000179148" "ALOXE3" "B2R981; B7Z3W0; hsa:59344; Q3ZB74; Q9BYJ1; Q9H4F2; Q9HC22" "Omega-6-fatty acids in senescence" "Synthesis of 12-eicosatetraenoic acid derivatives" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7092201439847483958" "False" "Low" "IsMasterProtein" "Q8TBG4" "Ethanolamine-phosphate phospho-lyase OS=Homo sapiens OX=9606 GN=ETNPPL PE=1 SV=1" "0.052" "False" "1.229" "2" "1" "1" "1" "499" "55.6" "8.10" "0.00" "1" "" "mitochondrion" "other molecular function" "Pf00202" "64850" "ENSG00000164089" "ETNPPL" "B7Z1Y0; E9PBY0; hsa:64850; Q8TBG4; Q9H174" "" "Synthesis of PE" "1" "0" "1.022" "1.033" "1.169" "1.081" "0.947" "1.103" "0.903" "1.092" "1.024" "87.9" "89.8" "90.8" "102.8" "95.0" "83.3" "97.0" "79.4" "96.0" "90.0" "" "" "" "" "" "" "" "" "" "" "82.4" "74.3" "84.3" "79.5" "81.0" "79.6" "88.6" "70.5" "96.0" "86.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3646985614586504558" "False" "Low" "IsMasterProtein" "P08572" "Collagen alpha-2(IV) chain OS=Homo sapiens OX=9606 GN=COL4A2 PE=1 SV=4" "0.052" "False" "1.228" "0" "1" "1" "1" "1712" "167.4" "8.66" "1.92" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;ER/Golgi" "extracellular structural activity;other molecular function" "Pf01391, Pf01413" "1284" "ENSG00000134871" "COL4A2" "hsa:1284; P08572; Q14052; Q548C3; Q5VZA9; Q66K23" "miRNA targets in ECM and membrane receptors; Focal adhesion; Hepatitis C and hepatocellular carcinoma; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; Small cell lung cancer; Pleural mesothelioma" "Collagen degradation; Signaling by PDGF; Integrin cell surface interactions; ECM proteoglycans; NCAM1 interactions; Collagen chain trimerization; Non-integrin membrane-ECM interactions; Laminin interactions; Anchoring fibril formation; Crosslinking of collagen fibrils; Scavenging by Class A Receptors" "22" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8292858060301668306" "False" "Low" "IsMasterProtein" "Q8IVF6" "Ankyrin repeat domain-containing protein 18A OS=Homo sapiens OX=9606 GN=ANKRD18A PE=2 SV=3" "0.052" "False" "1.227" "1" "1" "1" "1" "992" "115.5" "7.83" "2.26" "1" "" "" "" "Pf12001, Pf12796, Pf14915" "253650" "ENSG00000180071" "ANKRD18A" "A7MD11; A8MVU5; hsa:253650; Q5SY86; Q7Z468; Q8IVF6; Q8NA88" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8780259354878837006" "False" "Low" "IsMasterProtein" "Q7Z7L7" "Protein zer-1 homolog OS=Homo sapiens OX=9606 GN=ZER1 PE=1 SV=1" "0.052" "False" "1.226" "1" "1" "1" "1" "766" "88.1" "5.62" "1.68" "1" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "" "" "10444" "ENSG00000160445" "ZER1" "hsa:10444; O00156; Q5T272; Q5T273; Q7Z7L7" "" "" "0" "0" "0.931" "0.953" "0.972" "0.985" "0.997" "0.993" "0.948" "0.895" "0.903" "47.0" "43.8" "44.8" "45.7" "46.3" "46.9" "46.7" "44.6" "42.1" "42.4" "" "" "" "" "" "" "" "" "" "" "44.1" "36.2" "41.6" "35.3" "39.5" "44.8" "42.7" "39.6" "42.1" "40.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1318692346016185805" "False" "Low" "IsMasterProtein" "Q96MF0" "Putative uncharacterized protein LOC100506887 OS=Homo sapiens OX=9606 PE=5 SV=2" "0.053" "False" "1.225" "13" "1" "1" "1" "132" "14.6" "8.43" "1.64" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1500444669998282426" "False" "Low" "IsMasterProtein" "Q6ZUX3" "TOG array regulator of axonemal microtubules protein 2 OS=Homo sapiens OX=9606 GN=TOGARAM2 PE=1 SV=2" "0.053" "False" "1.225" "1" "1" "1" "1" "1019" "111.1" "9.42" "0.00" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf12348" "165186" "ENSG00000189350" "TOGARAM2" "Q6ZUF5; Q6ZUX3" "" "" "0" "0" "0.858" "0.966" "1.234" "1.075" "1.009" "0.933" "1.186" "0.847" "0.987" "91.1" "78.1" "87.9" "112.3" "97.9" "91.9" "85.0" "108.0" "77.1" "89.9" "" "" "" "" "" "" "" "" "" "" "85.3" "64.6" "81.6" "86.8" "83.4" "87.8" "77.6" "95.9" "77.1" "86.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4400189645946568146" "False" "Low" "IsMasterProtein" "O00488" "Zinc finger protein 593 OS=Homo sapiens OX=9606 GN=ZNF593 PE=1 SV=2" "0.053" "False" "1.225" "13" "1" "1" "1" "134" "15.2" "9.82" "0.00" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12171" "51042" "ENSG00000142684" "ZNF593" "B2R4S0; hsa:51042; O00488; Q5T2H7" "" "" "0" "0" "0.928" "0.905" "1.006" "0.979" "0.948" "0.962" "0.972" "0.919" "1.002" "75.4" "70.0" "68.3" "75.8" "73.8" "71.5" "72.6" "73.3" "69.3" "75.6" "" "" "" "" "" "" "" "" "" "" "70.7" "57.9" "63.4" "58.6" "62.9" "68.3" "66.3" "65.1" "69.3" "72.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7437759637941576864" "False" "Low" "IsMasterProtein" "Q92597" "Protein NDRG1 OS=Homo sapiens OX=9606 GN=NDRG1 PE=1 SV=1" "0.053" "False" "1.221" "4" "1" "1" "1" "394" "42.8" "5.82" "0.00" "1" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf03096" "10397" "ENSG00000104419" "NDRG1" "B3KR80; B7Z446; hsa:10397; O15207; Q6IBG2; Q92597; Q9NYR6; Q9UK29" "Androgen receptor network in prostate cancer; VEGFA-VEGFR2 signaling; Hippo-YAP signaling; Leukocyte-intrinsic Hippo pathway functions; Intracellular trafficking proteins involved in CMT neuropathy; Pleural mesothelioma; Macrophage-stimulating protein (MSP) signaling network map" "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7773792101669392702" "False" "Low" "IsMasterProtein" "O94880" "PHD finger protein 14 OS=Homo sapiens OX=9606 GN=PHF14 PE=1 SV=3" "0.053" "False" "1.220" "1" "1" "1" "1" "948" "106.9" "5.34" "1.93" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00628, Pf13831, Pf13832" "9678" "ENSG00000106443" "PHF14" "A0A0U1RRH6; A7MCZ3; B4DI82; hsa:9678; O94880" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-746323765343525932" "False" "Low" "IsMasterProtein" "Q9Y5G6" "Protocadherin gamma-A7 OS=Homo sapiens OX=9606 GN=PCDHGA7 PE=1 SV=1" "0.053" "False" "1.219" "1" "1" "1" "1" "932" "101.7" "4.88" "2.07" "1" "cell adhesion;developmental processes" "plasma membrane;other membranes" "other molecular function" "Pf00028, Pf08266, Pf15974, Pf16492" "56108" "ENSG00000253537" "PCDHGA7" "B2RN87; hsa:56108; Q9Y5D0; Q9Y5G6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3557303824053033167" "False" "Low" "IsMasterProtein" "Q01094" "Transcription factor E2F1 OS=Homo sapiens OX=9606 GN=E2F1 PE=1 SV=1" "0.053" "False" "1.217" "3" "1" "1" "1" "437" "46.9" "4.92" "2.33" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02319, Pf16421" "1869" "ENSG00000101412" "E2F1" "hsa:1869; Q01094; Q13143; Q92768" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Adipogenesis; Spinal cord injury; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor pathway; Mammary gland development pathway - Involution (Stage 4 of 4); Bladder cancer; MECP2 and associated Rett syndrome; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Prader-Willi and Angelman syndrome; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Effect of progerin on genes involved in progeria; EGF/EGFR signaling pathway; G1 to S cell cycle control; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Opioid receptor pathways; Sphingolipid metabolism in senescence; DNA damage response" "Oxidative Stress Induced Senescence; Pre-NOTCH Transcription and Translation; Transcriptional regulation of granulopoiesis; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Transcriptional Regulation by E2F6; Oncogene Induced Senescence; G2 Phase; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Activation of PUMA and translocation to mitochondria; G1/S-Specific Transcription; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Activation of NOXA and translocation to mitochondria; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "45" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1352370190722133700" "False" "Low" "IsMasterProtein" "O75746" "Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial OS=Homo sapiens OX=9606 GN=SLC25A12 PE=1 SV=2" "0.053" "False" "1.217" "1" "1" "1" "1" "678" "74.7" "8.38" "1.68" "1" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00153" "8604" "ENSG00000115840; ENSG00000292099" "SLC25A12" "B3KR64; hsa:8604; O75746; Q96AM8" "" "Gluconeogenesis; Mitochondrial protein import; Aspartate and asparagine metabolism" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6329020646840659358" "False" "Low" "IsMasterProtein" "Q8NER1" "Transient receptor potential cation channel subfamily V member 1 OS=Homo sapiens OX=9606 GN=TRPV1 PE=1 SV=2" "0.053" "False" "1.216" "1" "1" "1" "1" "839" "94.9" "7.24" "1.63" "1" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;other molecular function" "Pf00023, Pf00520, Pf12796" "7442" "ENSG00000196689" "TRPV1" "A2RUA9; hsa:7442; Q3LU47; Q8NER1; Q9H0G9; Q9H303; Q9H304; Q9NQ74; Q9NY22" "Serotonin and anxiety; Eicosanoid metabolism via lipooxygenases (LOX); Acetaminophen in analgesia and antipyresis" "TRP channels" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3224217066640378680" "False" "Low" "IsMasterProtein" "Q6GTS8" "N-fatty-acyl-amino acid synthase/hydrolase PM20D1 OS=Homo sapiens OX=9606 GN=PM20D1 PE=1 SV=3" "0.053" "False" "1.215" "1" "1" "1" "1" "502" "55.7" "6.67" "0.00" "1" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular" "other molecular function" "Pf01546, Pf07687" "148811" "ENSG00000162877" "PM20D1" "hsa:148811; Q6GTS8; Q6P4E3; Q96DM4" "" "Oleoyl-phe metabolism" "1" "0" "1.000" "0.868" "1.190" "0.984" "0.880" "1.152" "0.922" "0.955" "0.978" "154.6" "154.5" "134.3" "184.0" "152.2" "136.1" "178.1" "142.5" "147.6" "151.2" "" "" "" "" "" "" "" "" "" "" "144.9" "127.9" "124.6" "142.3" "129.7" "130.0" "162.8" "126.5" "147.6" "145.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2004821673015856317" "False" "Low" "IsMasterProtein" "Q9Y6Q3" "Zinc finger protein 37 homolog OS=Homo sapiens OX=9606 GN=ZFP37 PE=1 SV=3" "0.054" "False" "1.212" "2" "1" "1" "1" "630" "71.2" "9.09" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "7539" "ENSG00000136866" "ZFP37" "A0AVJ9; B4DVX4; G3V3L7; hsa:7539; Q5T7Q4; Q9Y6Q3" "" "Generic Transcription Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8470537921174600195" "False" "Low" "IsMasterProtein" "Q9NZM1" "Myoferlin OS=Homo sapiens OX=9606 GN=MYOF PE=1 SV=1" "0.054" "False" "1.211" "0" "1" "1" "1" "2061" "234.6" "6.18" "0.00" "1" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00168, Pf08150, Pf08151, Pf08165, Pf16165" "26509" "ENSG00000138119" "MYOF" "B3KQN5; hsa:26509; Q5VWW2; Q5VWW3; Q5VWW4; Q5VWW5; Q7Z642; Q8IWH0; Q9HBU3; Q9NZM0; Q9NZM1; Q9ULL3; Q9Y4U4" "Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Hepatitis C and hepatocellular carcinoma" "" "3" "0" "1.162" "1.178" "1.208" "0.828" "0.840" "1.164" "1.071" "1.157" "0.765" "17.1" "19.9" "20.2" "20.7" "14.2" "14.4" "19.9" "18.3" "19.8" "13.1" "" "" "" "" "" "" "" "" "" "" "16.0" "16.5" "18.7" "16.0" "12.1" "13.7" "18.2" "16.3" "19.8" "12.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8122664404387137367" "False" "Low" "IsMasterProtein" "Q96JP5" "E3 ubiquitin-protein ligase ZFP91 OS=Homo sapiens OX=9606 GN=ZFP91 PE=1 SV=1" "0.054" "False" "1.209" "2" "1" "1" "1" "570" "63.4" "7.36" "0.00" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf00096" "80829" "ENSG00000186660" "ZFP91" "A6NHC4; A8MSG7; Q86V47; Q96JP4; Q96JP5; Q96QA3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2644612551078172980" "False" "Low" "IsMasterProtein" "Q9NYQ3" "2-Hydroxyacid oxidase 2 OS=Homo sapiens OX=9606 GN=HAO2 PE=1 SV=1" "0.054" "False" "1.208" "2" "1" "1" "1" "351" "38.8" "7.64" "3.20" "1" "other metabolic processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf01070" "51179" "ENSG00000116882" "HAO2" "hsa:51179; Q2TU86; Q5QP00; Q9NYQ3; Q9UJS6" "" "Peroxisomal lipid metabolism; Peroxisomal protein import" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2166697322049180134" "False" "Low" "IsMasterProtein" "Q9UG01" "Intraflagellar transport protein 172 homolog OS=Homo sapiens OX=9606 GN=IFT172 PE=1 SV=2" "0.054" "False" "1.207" "1" "1" "1" "1" "1749" "197.5" "6.13" "2.18" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "" "Pf00400" "26160" "ENSG00000138002" "IFT172" "A5PKZ0; B2RNU5; hsa:26160; Q86X44; Q96HW4; Q9UFJ9; Q9UG01; Q9ULP1" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies; Alstrom syndrome; Bardet-Biedl syndrome" "Intraflagellar transport; Hedgehog 'off' state" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8429437180713985689" "False" "Low" "IsMasterProtein" "Q13761" "Runt-related transcription factor 3 OS=Homo sapiens OX=9606 GN=RUNX3 PE=1 SV=2" "0.054" "False" "1.206" "2" "1" "1" "1" "415" "44.3" "9.47" "1.73" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00853, Pf08504" "864" "ENSG00000020633" "RUNX3" "B1AJV5; hsa:864; Q12969; Q13760; Q13761" "TYROBP causal network in microglia; Endochondral ossification; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "Regulation of RUNX3 expression and activity; RUNX3 regulates BCL2L11 (BIM) transcription; Binding of TCF/LEF:CTNNB1 to target gene promoters; RUNX3 regulates WNT signaling; RUNX3 regulates p14-ARF; RUNX3 regulates CDKN1A transcription; RUNX3 Regulates Immune Response and Cell Migration; RUNX3 regulates YAP1-mediated transcription; RUNX3 regulates NOTCH signaling; RUNX3 regulates RUNX1-mediated transcription" "16" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1789714404780526606" "False" "Low" "IsMasterProtein" "Q8WUJ3" "Cell migration-inducing and hyaluronan-binding protein OS=Homo sapiens OX=9606 GN=CEMIP PE=1 SV=2" "0.054" "False" "1.204" "1" "1" "2" "1" "1361" "152.9" "7.85" "0.00" "1" "other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf10162, Pf13330, Pf15711" "57214" "ENSG00000103888" "CEMIP" "hsa:57214; Q6L9J5; Q8WUJ3; Q9H1K5; Q9NPN9; Q9ULM1" "" "Hyaluronan biosynthesis and export" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1684474116770674977" "False" "Low" "IsMasterProtein" "Q9NW68" "BSD domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BSDC1 PE=1 SV=1" "0.054" "False" "1.203" "2" "1" "1" "1" "430" "47.1" "4.49" "0.00" "1" "" "other cell component" "" "Pf03909" "55108" "ENSG00000160058" "BSDC1" "B4DMS7; B4DTI7; B4DTP7; B4E2X8; hsa:55108; Q49AT8; Q68DY6; Q6IAA3; Q6MZK1; Q6UXS1; Q9HAL9; Q9NW68" "" "" "0" "0" "1.018" "0.943" "1.096" "0.959" "0.951" "1.043" "0.946" "1.305" "0.962" "116.7" "118.8" "110.1" "128.0" "111.9" "111.0" "121.8" "110.5" "152.3" "112.3" "" "" "" "" "" "" "" "" "" "" "109.4" "98.3" "102.2" "98.9" "95.4" "106.0" "111.2" "98.1" "152.3" "108.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "542568515392763478" "False" "Low" "IsMasterProtein" "Q9H3M7" "Thioredoxin-interacting protein OS=Homo sapiens OX=9606 GN=TXNIP PE=1 SV=1" "0.055" "False" "1.202" "2" "1" "1" "1" "391" "43.6" "7.50" "0.00" "1" "cell cycle OR cell proliferation;stress response;transport;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00339, Pf02752" "10628" "ENSG00000265972" "TXNIP" "B4E3D3; hsa:10628; Q16226; Q6PML0; Q9BXG9; Q9H3M7" "VEGFA-VEGFR2 signaling; Unfolded protein response" "Cytoprotection by HMOX1; Regulation of FOXO transcriptional activity by acetylation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection" "6" "0" "0.865" "1.130" "0.903" "0.931" "0.931" "0.830" "0.877" "0.866" "0.917" "286.5" "247.7" "323.7" "258.6" "266.8" "266.7" "237.6" "251.2" "248.0" "262.7" "" "" "" "" "" "" "" "" "" "" "268.4" "205.0" "300.5" "199.9" "227.4" "254.8" "217.1" "223.1" "248.0" "252.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2627879840670290884" "False" "Low" "IsMasterProtein" "Q71F56" "Mediator of RNA polymerase II transcription subunit 13-like OS=Homo sapiens OX=9606 GN=MED13L PE=1 SV=1" "0.055" "False" "1.201" "0" "1" "1" "1" "2210" "242.4" "6.04" "0.00" "1" "other biological processes" "nucleus" "other molecular function" "Pf06333, Pf11597, Pf18296" "23389" "ENSG00000123066" "MED13L" "A1L469; hsa:23389; Q68DN4; Q71F56; Q9H8C0; Q9NSY9; Q9UFD8; Q9UPX5" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6788339784532223415" "False" "Low" "IsMasterProtein" "Q86UK0" "Glucosylceramide transporter ABCA12 OS=Homo sapiens OX=9606 GN=ABCA12 PE=1 SV=3" "0.055" "False" "1.201" "0" "1" "1" "1" "2595" "293.0" "7.75" "0.00" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00005, Pf12698" "26154" "ENSG00000144452" "ABCA12" "hsa:26154; Q53QE2; Q53S55; Q86UK0; Q8IZW6; Q96JT3; Q9Y4M5" "" "ABC transporters in lipid homeostasis; Defective ABCA12 causes ARCI4B" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9146373126346510516" "False" "Low" "IsMasterProtein" "Q96SL8" "Flt3-interacting zinc finger protein 1 OS=Homo sapiens OX=9606 GN=FIZ1 PE=1 SV=2" "0.055" "False" "1.199" "2" "1" "1" "1" "496" "52.0" "8.19" "0.00" "1" "other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00096" "84922" "ENSG00000179943" "FIZ1" "A2RU72; Q6ZMJ7; Q96SL8" "" "" "0" "0" "1.002" "0.967" "1.186" "0.992" "1.043" "1.133" "1.066" "0.985" "0.925" "152.8" "153.1" "147.7" "181.3" "151.6" "159.4" "173.2" "162.9" "150.5" "141.4" "" "" "" "" "" "" "" "" "" "" "143.2" "126.7" "137.1" "140.2" "129.2" "152.3" "158.2" "144.6" "150.5" "136.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4445024882537004002" "False" "Low" "IsMasterProtein" "Q9UPX8" "SH3 and multiple ankyrin repeat domains protein 2 OS=Homo sapiens OX=9606 GN=SHANK2 PE=1 SV=4" "0.055" "False" "1.197" "0" "1" "1" "1" "1849" "201.1" "6.70" "0.00" "1" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00536, Pf07653, Pf12796, Pf16511, Pf17820" "22941" "ENSG00000162105" "SHANK2" "C0SPG8; C0SPG9; hsa:22941; Q3Y8G9; Q52LK2; Q9UKP1; Q9UPX8" "" "Neurexins and neuroligins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5718425879565381885" "False" "Low" "IsMasterProtein" "P49761" "Dual specificity protein kinase CLK3 OS=Homo sapiens OX=9606 GN=CLK3 PE=1 SV=4" "0.055" "False" "1.197" "1" "1" "1" "1" "490" "58.6" "9.52" "2.37" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7935132713264625500" "False" "Low" "IsMasterProtein" "Q7Z5M5" "Transmembrane channel-like protein 3 OS=Homo sapiens OX=9606 GN=TMC3 PE=2 SV=3" "0.055" "False" "1.196" "2" "1" "1" "1" "1100" "125.6" "9.19" "2.62" "1" "transport" "plasma membrane;other membranes" "transporter activity" "Pf07810" "342125" "ENSG00000188869" "TMC3" "A2RTY2; B2RXJ3; hsa:342125; Q7Z405; Q7Z5M5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6586229541636878112" "False" "Low" "IsMasterProtein" "P25940" "Collagen alpha-3(V) chain OS=Homo sapiens OX=9606 GN=COL5A3 PE=1 SV=3" "0.055" "False" "1.195" "1" "1" "1" "1" "1745" "172.0" "6.87" "0.00" "1" "cell adhesion;cell organization and biogenesis;other biological processes" "non-structural extracellular;extracellular matrix;ER/Golgi" "extracellular structural activity;other molecular function" "Pf01391, Pf01410" "50509" "ENSG00000080573" "COL5A3" "hsa:50509; P25940; Q9NZQ6" "miRNA targets in ECM and membrane receptors; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Collagen degradation; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; ECM proteoglycans; NCAM1 interactions; Collagen chain trimerization; Syndecan interactions; MET activates PTK2 signaling" "15" "0" "0.973" "1.016" "1.132" "1.112" "1.044" "0.998" "1.055" "1.060" "1.088" "121.2" "117.9" "123.1" "137.3" "134.9" "126.5" "121.0" "127.9" "128.5" "131.9" "" "" "" "" "" "" "" "" "" "" "113.6" "97.6" "114.3" "106.1" "114.9" "120.9" "110.6" "113.6" "128.5" "127.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-233875038678641110" "False" "Low" "IsMasterProtein" "Q7Z5U6" "WD repeat-containing protein 53 OS=Homo sapiens OX=9606 GN=WDR53 PE=1 SV=1" "0.056" "False" "1.193" "2" "1" "1" "1" "358" "39.0" "6.52" "2.41" "1" "" "" "" "Pf00400, Pf12894" "348793" "ENSG00000185798" "WDR53" "A0MNP1; hsa:348793; Q7Z5U6" "3q29 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625038226073765913" "False" "Low" "IsMasterProtein" "P61421" "V-type proton ATPase subunit d 1 OS=Homo sapiens OX=9606 GN=ATP6V0D1 PE=1 SV=1" "0.056" "False" "1.192" "2" "1" "1" "1" "351" "40.3" "5.00" "0.00" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf01992" "9114" "ENSG00000159720" "ATP6V0D1" "hsa:9114; P12953; P61421; Q02547" "VEGFA-VEGFR2 signaling" "Amino acids regulate mTORC1; XBP1(S) activates chaperone genes; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "7" "0" "1.285" "1.098" "1.017" "0.941" "1.207" "1.451" "0.703" "0.871" "1.016" "13.3" "17.0" "14.6" "13.5" "12.5" "16.0" "19.3" "9.3" "11.6" "13.5" "" "" "" "" "" "" "" "" "" "" "12.4" "14.1" "13.5" "10.4" "10.6" "15.3" "17.6" "8.3" "11.6" "13.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "697873925504819237" "False" "Low" "IsMasterProtein" "P50053" "Ketohexokinase OS=Homo sapiens OX=9606 GN=KHK PE=1 SV=2" "0.056" "False" "1.189" "2" "1" "1" "1" "298" "32.5" "6.32" "2.98" "1" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00294" "3795" "ENSG00000138030" "KHK" "hsa:3795; P50053; Q6IBK2; Q99532; Q9BRJ3; Q9UMN1" "Disorders of fructose metabolism; Polyol pathway" "Fructose catabolism; Essential fructosuria" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6124864541622501476" "False" "Low" "IsMasterProtein" "P35711" "Transcription factor SOX-5 OS=Homo sapiens OX=9606 GN=SOX5 PE=1 SV=3" "0.056" "False" "1.188" "2" "1" "1" "1" "763" "84.0" "6.60" "2.19" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505" "6660" "ENSG00000134532" "SOX5" "B7Z8V0; F5H5B0; hsa:6660; P35711; Q86UK8; Q8J017; Q8J018; Q8J019; Q8J020; Q8N1D9; Q8N7E0; Q8TEA4" "Neural crest differentiation; Male infertility; Endochondral ossification; Endochondral ossification with skeletal dysplasias" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8985858541616026476" "False" "Low" "IsMasterProtein" "Q7L5N7" "Lysophosphatidylcholine acyltransferase 2 OS=Homo sapiens OX=9606 GN=LPCAT2 PE=1 SV=1" "0.056" "False" "1.188" "1" "1" "1" "1" "544" "60.2" "6.55" "0.00" "1" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01553, Pf13202, Pf13499" "54947" "ENSG00000087253" "LPCAT2" "A3KBM1; hsa:54947; Q6MZJ6; Q7L5N7; Q9NX23" "" "Acyl chain remodelling of PC" "1" "0" "1.007" "0.991" "1.103" "0.999" "1.031" "0.896" "1.076" "0.984" "1.011" "163.2" "164.4" "161.7" "180.0" "163.0" "168.3" "146.1" "175.5" "160.6" "164.9" "" "" "" "" "" "" "" "" "" "" "152.9" "136.0" "150.2" "139.1" "138.9" "160.8" "133.5" "155.8" "160.6" "158.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3318017659961933117" "False" "Low" "IsMasterProtein" "Q9NVA1" "Ubiquinol-cytochrome c reductase complex assembly factor 1 OS=Homo sapiens OX=9606 GN=UQCC1 PE=1 SV=3" "0.056" "False" "1.188" "3" "1" "1" "1" "299" "34.6" "8.91" "0.00" "1" "cell organization and biogenesis" "other membranes;mitochondrion;other cell component" "" "Pf03981" "55245" "ENSG00000101019" "UQCC1" "B1AKV5; hsa:55245; Q0VF37; Q5T348; Q5T351; Q5T353; Q86YU3; Q86YU4; Q96H66; Q9H438; Q9H452; Q9H9K8; Q9H9R5; Q9NVA1" "Ciliary landscape; Mitochondrial complex III assembly" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2769087556665891581" "False" "Low" "IsMasterProtein" "P35556" "Fibrillin-2 OS=Homo sapiens OX=9606 GN=FBN2 PE=1 SV=3" "0.057" "False" "1.180" "0" "1" "1" "1" "2912" "314.6" "4.86" "0.00" "1" "developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix" "signal transduction activity or receptor binding;extracellular structural activity;other molecular function" "Pf00683, Pf07645, Pf12661, Pf12662, Pf12947, Pf18193, Pf21364" "2201" "ENSG00000138829" "FBN2" "B4DU01; hsa:2201; P35556; Q59ES6" "Hypothesized pathways in pathogenesis of cardiovascular disease" "Degradation of the extracellular matrix; Molecules associated with elastic fibres" "4" "0" "1.047" "0.996" "1.176" "0.966" "0.825" "1.024" "1.183" "1.161" "0.813" "46.1" "48.2" "45.9" "54.2" "44.5" "38.0" "47.2" "54.5" "53.5" "37.5" "" "" "" "" "" "" "" "" "" "" "43.2" "39.9" "42.6" "41.9" "37.9" "36.3" "43.1" "48.4" "53.5" "36.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7061305682982292467" "False" "Low" "IsMasterProtein" "Q5T5J6" "Transcriptional protein SWT1 OS=Homo sapiens OX=9606 GN=SWT1 PE=1 SV=1" "0.057" "False" "1.179" "2" "1" "1" "1" "900" "103.2" "8.81" "2.45" "1" "" "nucleus" "" "Pf13638" "54823" "ENSG00000116668" "SWT1" "hsa:54823; Q5T5J6; Q8NEK9; Q9BZQ7; Q9NXQ0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7892185460647837485" "False" "Low" "IsMasterProtein" "Q53RE8" "Ankyrin repeat domain-containing protein 39 OS=Homo sapiens OX=9606 GN=ANKRD39 PE=1 SV=1" "0.057" "False" "1.178" "5" "1" "1" "1" "183" "19.6" "6.89" "1.78" "1" "" "" "" "Pf12796" "51239" "ENSG00000213337" "ANKRD39" "hsa:51239; Q53RE8; Q59FU2; Q8N5X5; Q9P0S5" "2q11.2 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2271404358644786379" "False" "Low" "IsMasterProtein" "P46778" "Large ribosomal subunit protein eL21 OS=Homo sapiens OX=9606 GN=RPL21 PE=1 SV=2" "0.057" "False" "1.177" "4" "1" "1" "1" "160" "18.6" "10.49" "2.52" "1" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "other molecular function" "Pf01157" "6144" "ENSG00000122026" "RPL21" "hsa:6144; P46778; Q16699" "Cytoplasmic ribosomal proteins" "Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5201003566343787009" "False" "Low" "IsMasterProtein" "P62273" "Small ribosomal subunit protein uS14 OS=Homo sapiens OX=9606 GN=RPS29 PE=1 SV=2" "0.058" "False" "1.175" "11" "1" "1" "1" "56" "6.7" "10.13" "2.61" "1" "protein metabolism;other metabolic processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00253" "6235" "ENSG00000213741" "RPS29" "A8MZ73; hsa:6235; P30054; P62273" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4307580896062222592" "False" "Low" "IsMasterProtein" "Q8N3U1" "Putative uncharacterized protein LOC400692 OS=Homo sapiens OX=9606 PE=2 SV=2" "0.058" "False" "1.173" "5" "1" "1" "1" "123" "12.7" "5.87" "0.00" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1053300951170364696" "False" "Low" "IsMasterProtein" "Q9UIG0" "Tyrosine-protein kinase BAZ1B OS=Homo sapiens OX=9606 GN=BAZ1B PE=1 SV=2" "0.058" "False" "1.171" "0" "1" "1" "1" "1483" "170.8" "8.48" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00439, Pf00628, Pf10537, Pf15612, Pf15613" "9031" "ENSG00000009954" "BAZ1B" "B9EGK3; D3DXE9; hsa:9031; O95039; O95247; O95277; Q6P1K4; Q86UJ6; Q9UIG0" "IL-18 signaling pathway; 7q11.23 copy number variation syndrome; 10q11.21q11.23 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2615595285303873968" "False" "Low" "IsMasterProtein" "Q9UPS8" "Ankyrin repeat domain-containing protein 26 OS=Homo sapiens OX=9606 GN=ANKRD26 PE=1 SV=4" "0.059" "False" "1.164" "1" "1" "1" "1" "1710" "196.3" "5.72" "2.90" "1" "other biological processes" "cytoskeleton" "" "Pf12001, Pf12796, Pf14915" "22852" "ENSG00000107890" "ANKRD26" "A6NH29; hsa:22852; Q2TAZ3; Q6ZR14; Q9H1Q1; Q9NSK9; Q9NTD5; Q9NW69; Q9UPS8" "" "RND2 GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3241468308071992901" "False" "Low" "IsMasterProtein" "Q8NI08" "Nuclear receptor coactivator 7 OS=Homo sapiens OX=9606 GN=NCOA7 PE=1 SV=2" "0.059" "False" "1.164" "1" "1" "1" "1" "942" "106.1" "5.59" "3.21" "1" "stress response;other biological processes" "nucleus" "other molecular function" "Pf01476, Pf07534" "135112" "ENSG00000111912" "NCOA7" "B2RNS2; B7Z2C4; B9EH71; G8JL91; hsa:135112; Q3LID6; Q4G0V1; Q5TF95; Q6IPQ4; Q6NE83; Q86T89; Q8N1W4; Q8NI08" "Aryl hydrocarbon receptor pathway" "" "1" "0" "1.019" "0.986" "1.152" "1.146" "1.084" "1.096" "1.076" "1.053" "1.044" "198.3" "202.0" "195.6" "228.4" "227.1" "214.9" "217.3" "213.2" "208.8" "206.9" "" "" "" "" "" "" "" "" "" "" "185.8" "167.2" "181.6" "176.6" "193.6" "205.3" "198.5" "189.3" "208.8" "199.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8683427190247271421" "False" "Low" "IsMasterProtein" "P15428" "15-hydroxyprostaglandin dehydrogenase [NAD(+)] OS=Homo sapiens OX=9606 GN=HPGD PE=1 SV=1" "0.059" "False" "1.163" "5" "1" "2" "1" "266" "29.0" "5.86" "4.76" "1" "other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00106" "3248" "ENSG00000164120" "HPGD" "B4DTA4; B4DU74; B4DV57; D3DP43; E7EV11; hsa:3248; O00749; P15428; Q06F08; Q12998" "Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-6-fatty acids in senescence; Prostaglandin synthesis and regulation" "Synthesis of Prostaglandins (PG) and Thromboxanes (TX); Synthesis of Lipoxins (LX); Biosynthesis of D-series resolvins; Biosynthesis of E-series 18(S)-resolvins" "8" "0" "1.090" "0.993" "1.053" "1.208" "1.157" "0.962" "1.155" "1.210" "1.120" "246.7" "268.9" "245.0" "259.8" "297.9" "285.5" "237.3" "284.8" "298.5" "276.3" "" "" "" "" "" "" "" "" "" "" "231.1" "222.5" "227.4" "200.8" "253.9" "272.7" "216.8" "252.9" "298.5" "266.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8599479812302819490" "False" "Low" "IsMasterProtein" "Q9UKY0" "Prion-like protein doppel OS=Homo sapiens OX=9606 GN=PRND PE=1 SV=2" "0.059" "False" "1.158" "6" "1" "1" "1" "176" "20.3" "9.03" "0.00" "1" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf00377, Pf11466" "23627" "ENSG00000171864" "PRND" "A7U7M5; Q9H311; Q9H312; Q9NTM4; Q9UKY0" "" "Post-translational modification: synthesis of GPI-anchored proteins" "1" "0" "0.699" "1.070" "1.303" "1.318" "0.867" "1.244" "0.933" "0.851" "0.944" "15.8" "11.0" "16.9" "20.6" "20.8" "13.7" "19.6" "14.7" "13.4" "14.9" "" "" "" "" "" "" "" "" "" "" "14.8" "9.1" "15.7" "15.9" "17.7" "13.1" "18.0" "13.1" "13.4" "14.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" ""